-- dump date 20140619_151356 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1206780000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1206780000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780000003 Walker A motif; other site 1206780000004 ATP binding site [chemical binding]; other site 1206780000005 Walker B motif; other site 1206780000006 arginine finger; other site 1206780000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1206780000008 DnaA box-binding interface [nucleotide binding]; other site 1206780000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1206780000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1206780000011 putative DNA binding surface [nucleotide binding]; other site 1206780000012 dimer interface [polypeptide binding]; other site 1206780000013 beta-clamp/clamp loader binding surface; other site 1206780000014 beta-clamp/translesion DNA polymerase binding surface; other site 1206780000015 recF protein; Region: recf; TIGR00611 1206780000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1206780000017 Walker A/P-loop; other site 1206780000018 ATP binding site [chemical binding]; other site 1206780000019 Q-loop/lid; other site 1206780000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206780000021 ABC transporter signature motif; other site 1206780000022 Walker B; other site 1206780000023 D-loop; other site 1206780000024 H-loop/switch region; other site 1206780000025 hypothetical protein; Provisional; Region: PRK03195 1206780000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1206780000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206780000028 Mg2+ binding site [ion binding]; other site 1206780000029 G-X-G motif; other site 1206780000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1206780000031 anchoring element; other site 1206780000032 dimer interface [polypeptide binding]; other site 1206780000033 ATP binding site [chemical binding]; other site 1206780000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1206780000035 active site 1206780000036 putative metal-binding site [ion binding]; other site 1206780000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1206780000038 DNA gyrase subunit A; Validated; Region: PRK05560 1206780000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1206780000040 CAP-like domain; other site 1206780000041 active site 1206780000042 primary dimer interface [polypeptide binding]; other site 1206780000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206780000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206780000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206780000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206780000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206780000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1206780000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1206780000050 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1206780000051 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1206780000052 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1206780000053 active site 1206780000054 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1206780000055 putative septation inhibitor protein; Reviewed; Region: PRK00159 1206780000056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1206780000057 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1206780000058 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1206780000059 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1206780000060 glutamine binding [chemical binding]; other site 1206780000061 catalytic triad [active] 1206780000062 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1206780000063 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1206780000064 active site 1206780000065 ATP binding site [chemical binding]; other site 1206780000066 substrate binding site [chemical binding]; other site 1206780000067 activation loop (A-loop); other site 1206780000068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1206780000069 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1206780000070 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1206780000071 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1206780000072 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1206780000073 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1206780000074 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1206780000075 active site 1206780000076 ATP binding site [chemical binding]; other site 1206780000077 substrate binding site [chemical binding]; other site 1206780000078 activation loop (A-loop); other site 1206780000079 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1206780000080 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1206780000081 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1206780000082 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1206780000083 active site 1206780000084 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1206780000085 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1206780000086 phosphopeptide binding site; other site 1206780000087 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1206780000088 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1206780000089 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1206780000090 phosphopeptide binding site; other site 1206780000091 Nitronate monooxygenase; Region: NMO; pfam03060 1206780000092 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1206780000093 FMN binding site [chemical binding]; other site 1206780000094 substrate binding site [chemical binding]; other site 1206780000095 putative catalytic residue [active] 1206780000096 Transcription factor WhiB; Region: Whib; pfam02467 1206780000097 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206780000098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206780000099 non-specific DNA binding site [nucleotide binding]; other site 1206780000100 salt bridge; other site 1206780000101 sequence-specific DNA binding site [nucleotide binding]; other site 1206780000102 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1206780000103 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1206780000104 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1206780000105 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1206780000106 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1206780000107 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1206780000108 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1206780000109 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1206780000110 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206780000111 catalytic residue [active] 1206780000112 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1206780000113 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1206780000114 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1206780000115 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1206780000116 acyl-activating enzyme (AAE) consensus motif; other site 1206780000117 active site 1206780000118 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1206780000119 H+ Antiporter protein; Region: 2A0121; TIGR00900 1206780000120 hypothetical protein; Validated; Region: PRK00228 1206780000121 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1206780000122 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1206780000123 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1206780000124 active site 1206780000125 HIGH motif; other site 1206780000126 nucleotide binding site [chemical binding]; other site 1206780000127 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1206780000128 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1206780000129 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1206780000130 active site 1206780000131 KMSKS motif; other site 1206780000132 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1206780000133 tRNA binding surface [nucleotide binding]; other site 1206780000134 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1206780000135 MarR family; Region: MarR; pfam01047 1206780000136 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1206780000137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206780000138 DNA-binding site [nucleotide binding]; DNA binding site 1206780000139 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1206780000140 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1206780000141 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206780000142 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1206780000143 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1206780000144 Predicted transcriptional regulators [Transcription]; Region: COG1695 1206780000145 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1206780000146 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1206780000147 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1206780000148 Transglycosylase; Region: Transgly; pfam00912 1206780000149 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1206780000150 Predicted integral membrane protein [Function unknown]; Region: COG5650 1206780000151 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1206780000152 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1206780000153 conserved cys residue [active] 1206780000154 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1206780000155 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1206780000156 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1206780000157 dimer interface [polypeptide binding]; other site 1206780000158 ssDNA binding site [nucleotide binding]; other site 1206780000159 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1206780000160 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1206780000161 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1206780000162 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1206780000163 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1206780000164 replicative DNA helicase; Validated; Region: PRK07773 1206780000165 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1206780000166 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1206780000167 Walker A motif; other site 1206780000168 ATP binding site [chemical binding]; other site 1206780000169 Walker B motif; other site 1206780000170 DNA binding loops [nucleotide binding] 1206780000171 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1206780000172 protein-splicing catalytic site; other site 1206780000173 thioester formation/cholesterol transfer; other site 1206780000174 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1206780000175 protein-splicing catalytic site; other site 1206780000176 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1206780000177 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1206780000178 ADP-ribose binding site [chemical binding]; other site 1206780000179 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 1206780000180 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1206780000181 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1206780000182 FAD binding domain; Region: FAD_binding_4; pfam01565 1206780000183 Berberine and berberine like; Region: BBE; pfam08031 1206780000184 hypothetical protein; Provisional; Region: PRK12438 1206780000185 hypothetical protein; Validated; Region: PRK00068 1206780000186 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1206780000187 homotetrameric interface [polypeptide binding]; other site 1206780000188 putative active site [active] 1206780000189 metal binding site [ion binding]; metal-binding site 1206780000190 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1206780000191 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 1206780000192 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780000193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780000194 short chain dehydrogenase; Provisional; Region: PRK06197 1206780000195 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1206780000196 putative NAD(P) binding site [chemical binding]; other site 1206780000197 active site 1206780000198 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1206780000199 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1206780000200 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1206780000201 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1206780000202 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1206780000203 dimer interface [polypeptide binding]; other site 1206780000204 active site 1206780000205 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1206780000206 folate binding site [chemical binding]; other site 1206780000207 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1206780000208 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1206780000209 putative NTP binding site [chemical binding]; other site 1206780000210 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1206780000211 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1206780000212 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206780000213 Walker A/P-loop; other site 1206780000214 ATP binding site [chemical binding]; other site 1206780000215 Q-loop/lid; other site 1206780000216 ABC transporter signature motif; other site 1206780000217 Walker B; other site 1206780000218 D-loop; other site 1206780000219 H-loop/switch region; other site 1206780000220 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1206780000221 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1206780000222 ligand binding site [chemical binding]; other site 1206780000223 flexible hinge region; other site 1206780000224 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1206780000225 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1206780000226 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1206780000227 active site 1206780000228 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1206780000229 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206780000230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780000231 homodimer interface [polypeptide binding]; other site 1206780000232 catalytic residue [active] 1206780000233 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1206780000234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780000235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780000236 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1206780000237 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206780000238 dimerization interface [polypeptide binding]; other site 1206780000239 putative DNA binding site [nucleotide binding]; other site 1206780000240 putative Zn2+ binding site [ion binding]; other site 1206780000241 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1206780000242 hydrogenase 4 subunit B; Validated; Region: PRK06521 1206780000243 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1206780000244 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1206780000245 NADH dehydrogenase; Region: NADHdh; cl00469 1206780000246 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 1206780000247 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1206780000248 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1206780000249 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1206780000250 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1206780000251 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1206780000252 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1206780000253 putative hydrophobic ligand binding site [chemical binding]; other site 1206780000254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780000255 S-adenosylmethionine binding site [chemical binding]; other site 1206780000256 Predicted membrane protein [Function unknown]; Region: COG3305 1206780000257 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1206780000258 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1206780000259 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1206780000260 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206780000261 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1206780000262 Predicted integral membrane protein [Function unknown]; Region: COG5660 1206780000263 Putative zinc-finger; Region: zf-HC2; pfam13490 1206780000264 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780000265 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780000266 active site 1206780000267 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780000268 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780000269 PPE family; Region: PPE; pfam00823 1206780000270 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1206780000271 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1206780000272 FcoT-like thioesterase domain; Region: FcoT; pfam10862 1206780000273 acyl-CoA synthetase; Validated; Region: PRK05857 1206780000274 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780000275 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1206780000276 acyl-activating enzyme (AAE) consensus motif; other site 1206780000277 acyl-activating enzyme (AAE) consensus motif; other site 1206780000278 AMP binding site [chemical binding]; other site 1206780000279 active site 1206780000280 CoA binding site [chemical binding]; other site 1206780000281 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1206780000282 AMP-binding enzyme; Region: AMP-binding; pfam00501 1206780000283 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780000284 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780000285 acyl-activating enzyme (AAE) consensus motif; other site 1206780000286 acyl-activating enzyme (AAE) consensus motif; other site 1206780000287 active site 1206780000288 AMP binding site [chemical binding]; other site 1206780000289 CoA binding site [chemical binding]; other site 1206780000290 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1206780000291 Condensation domain; Region: Condensation; pfam00668 1206780000292 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1206780000293 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1206780000294 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1206780000295 acyl-activating enzyme (AAE) consensus motif; other site 1206780000296 AMP binding site [chemical binding]; other site 1206780000297 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1206780000298 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1206780000299 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1206780000300 putative NAD(P) binding site [chemical binding]; other site 1206780000301 active site 1206780000302 putative substrate binding site [chemical binding]; other site 1206780000303 Predicted membrane protein [Function unknown]; Region: COG3336 1206780000304 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1206780000305 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1206780000306 metal-binding site [ion binding] 1206780000307 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206780000308 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1206780000309 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1206780000310 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1206780000311 ligand binding site [chemical binding]; other site 1206780000312 flexible hinge region; other site 1206780000313 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1206780000314 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1206780000315 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1206780000316 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1206780000317 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206780000318 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1206780000319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206780000320 motif II; other site 1206780000321 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1206780000322 PE family; Region: PE; pfam00934 1206780000323 Rhomboid family; Region: Rhomboid; pfam01694 1206780000324 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1206780000325 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1206780000326 active site 1206780000327 catalytic triad [active] 1206780000328 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1206780000329 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1206780000330 NADP-binding site; other site 1206780000331 homotetramer interface [polypeptide binding]; other site 1206780000332 substrate binding site [chemical binding]; other site 1206780000333 homodimer interface [polypeptide binding]; other site 1206780000334 active site 1206780000335 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1206780000336 dimer interface [polypeptide binding]; other site 1206780000337 active site 1206780000338 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1206780000339 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206780000340 active site 1206780000341 motif I; other site 1206780000342 motif II; other site 1206780000343 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1206780000344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1206780000345 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1206780000346 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1206780000347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1206780000348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1206780000349 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1206780000350 dimerization interface [polypeptide binding]; other site 1206780000351 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1206780000352 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1206780000353 PYR/PP interface [polypeptide binding]; other site 1206780000354 dimer interface [polypeptide binding]; other site 1206780000355 TPP binding site [chemical binding]; other site 1206780000356 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1206780000357 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1206780000358 TPP-binding site; other site 1206780000359 dimer interface [polypeptide binding]; other site 1206780000360 acyl-CoA synthetase; Validated; Region: PRK05852 1206780000361 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780000362 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 1206780000363 acyl-activating enzyme (AAE) consensus motif; other site 1206780000364 acyl-activating enzyme (AAE) consensus motif; other site 1206780000365 putative AMP binding site [chemical binding]; other site 1206780000366 putative active site [active] 1206780000367 putative CoA binding site [chemical binding]; other site 1206780000368 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1206780000369 elongation factor G; Reviewed; Region: PRK12740 1206780000370 G1 box; other site 1206780000371 putative GEF interaction site [polypeptide binding]; other site 1206780000372 GTP/Mg2+ binding site [chemical binding]; other site 1206780000373 Switch I region; other site 1206780000374 G2 box; other site 1206780000375 G3 box; other site 1206780000376 Switch II region; other site 1206780000377 G4 box; other site 1206780000378 G5 box; other site 1206780000379 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1206780000380 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1206780000381 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1206780000382 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1206780000383 PE family; Region: PE; pfam00934 1206780000384 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1206780000385 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1206780000386 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1206780000387 trehalose synthase; Region: treS_nterm; TIGR02456 1206780000388 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1206780000389 active site 1206780000390 catalytic site [active] 1206780000391 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1206780000392 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1206780000393 Predicted membrane protein [Function unknown]; Region: COG3619 1206780000394 Predicted esterase [General function prediction only]; Region: COG0627 1206780000395 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1206780000396 putative active site [active] 1206780000397 putative catalytic site [active] 1206780000398 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780000399 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780000400 active site 1206780000401 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1206780000402 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1206780000403 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1206780000404 Coenzyme A binding pocket [chemical binding]; other site 1206780000405 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1206780000406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780000407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780000408 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780000409 Cytochrome P450; Region: p450; cl12078 1206780000410 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1206780000411 SnoaL-like domain; Region: SnoaL_2; pfam12680 1206780000412 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1206780000413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780000414 NAD(P) binding site [chemical binding]; other site 1206780000415 active site 1206780000416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1206780000417 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1206780000418 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1206780000419 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1206780000420 minor groove reading motif; other site 1206780000421 helix-hairpin-helix signature motif; other site 1206780000422 active site 1206780000423 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1206780000424 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1206780000425 Cl- selectivity filter; other site 1206780000426 Cl- binding residues [ion binding]; other site 1206780000427 pore gating glutamate residue; other site 1206780000428 dimer interface [polypeptide binding]; other site 1206780000429 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780000430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780000431 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1206780000432 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1206780000433 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1206780000434 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1206780000435 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1206780000436 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1206780000437 NAD(P) binding site [chemical binding]; other site 1206780000438 catalytic residues [active] 1206780000439 short chain dehydrogenase; Provisional; Region: PRK07791 1206780000440 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1206780000441 NAD binding site [chemical binding]; other site 1206780000442 homodimer interface [polypeptide binding]; other site 1206780000443 active site 1206780000444 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1206780000445 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1206780000446 NAD(P) binding site [chemical binding]; other site 1206780000447 PE family; Region: PE; pfam00934 1206780000448 PE-PPE domain; Region: PE-PPE; pfam08237 1206780000449 PE-PPE domain; Region: PE-PPE; pfam08237 1206780000450 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1206780000451 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1206780000452 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1206780000453 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780000454 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1206780000455 FAD binding site [chemical binding]; other site 1206780000456 substrate binding site [chemical binding]; other site 1206780000457 catalytic base [active] 1206780000458 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1206780000459 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1206780000460 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1206780000461 ligand binding site [chemical binding]; other site 1206780000462 homodimer interface [polypeptide binding]; other site 1206780000463 NAD(P) binding site [chemical binding]; other site 1206780000464 trimer interface B [polypeptide binding]; other site 1206780000465 trimer interface A [polypeptide binding]; other site 1206780000466 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1206780000467 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1206780000468 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1206780000469 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1206780000470 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780000471 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780000472 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1206780000473 PE family; Region: PE; pfam00934 1206780000474 PE-PPE domain; Region: PE-PPE; pfam08237 1206780000475 PE family; Region: PE; pfam00934 1206780000476 PE-PPE domain; Region: PE-PPE; pfam08237 1206780000477 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1206780000478 FAD binding domain; Region: FAD_binding_4; pfam01565 1206780000479 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1206780000480 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1206780000481 NAD(P) binding site [chemical binding]; other site 1206780000482 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1206780000483 active site 1206780000484 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1206780000485 putative hydrophobic ligand binding site [chemical binding]; other site 1206780000486 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1206780000487 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206780000488 DNA-binding site [nucleotide binding]; DNA binding site 1206780000489 FCD domain; Region: FCD; pfam07729 1206780000490 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1206780000491 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780000492 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1206780000493 acyl-activating enzyme (AAE) consensus motif; other site 1206780000494 acyl-activating enzyme (AAE) consensus motif; other site 1206780000495 putative AMP binding site [chemical binding]; other site 1206780000496 putative active site [active] 1206780000497 putative CoA binding site [chemical binding]; other site 1206780000498 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1206780000499 Permease; Region: Permease; pfam02405 1206780000500 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1206780000501 Permease; Region: Permease; pfam02405 1206780000502 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780000503 mce related protein; Region: MCE; pfam02470 1206780000504 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1206780000505 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780000506 mce related protein; Region: MCE; pfam02470 1206780000507 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1206780000508 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780000509 mce related protein; Region: MCE; pfam02470 1206780000510 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780000511 mce related protein; Region: MCE; pfam02470 1206780000512 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780000513 mce related protein; Region: MCE; pfam02470 1206780000514 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780000515 mce related protein; Region: MCE; pfam02470 1206780000516 RDD family; Region: RDD; pfam06271 1206780000517 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1206780000518 Predicted membrane protein [Function unknown]; Region: COG1511 1206780000519 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1206780000520 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1206780000521 Pirin-related protein [General function prediction only]; Region: COG1741 1206780000522 Pirin; Region: Pirin; pfam02678 1206780000523 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1206780000524 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206780000525 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206780000526 DNA binding residues [nucleotide binding] 1206780000527 SnoaL-like domain; Region: SnoaL_2; pfam12680 1206780000528 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1206780000529 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1206780000530 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1206780000531 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1206780000532 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1206780000533 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1206780000534 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1206780000535 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1206780000536 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1206780000537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780000538 S-adenosylmethionine binding site [chemical binding]; other site 1206780000539 SPW repeat; Region: SPW; pfam03779 1206780000540 SPW repeat; Region: SPW; pfam03779 1206780000541 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1206780000542 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1206780000543 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1206780000544 putative homodimer interface [polypeptide binding]; other site 1206780000545 putative homotetramer interface [polypeptide binding]; other site 1206780000546 putative allosteric switch controlling residues; other site 1206780000547 putative metal binding site [ion binding]; other site 1206780000548 putative homodimer-homodimer interface [polypeptide binding]; other site 1206780000549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780000550 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1206780000551 putative substrate translocation pore; other site 1206780000552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1206780000553 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1206780000554 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1206780000555 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206780000556 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206780000557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206780000558 Walker A/P-loop; other site 1206780000559 ATP binding site [chemical binding]; other site 1206780000560 Q-loop/lid; other site 1206780000561 ABC transporter signature motif; other site 1206780000562 Walker B; other site 1206780000563 D-loop; other site 1206780000564 H-loop/switch region; other site 1206780000565 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206780000566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206780000567 Walker A/P-loop; other site 1206780000568 ATP binding site [chemical binding]; other site 1206780000569 Q-loop/lid; other site 1206780000570 ABC transporter signature motif; other site 1206780000571 Walker B; other site 1206780000572 D-loop; other site 1206780000573 H-loop/switch region; other site 1206780000574 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1206780000575 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1206780000576 dimerization interface [polypeptide binding]; other site 1206780000577 DNA binding residues [nucleotide binding] 1206780000578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780000579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780000580 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1206780000581 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1206780000582 putative [Fe4-S4] binding site [ion binding]; other site 1206780000583 putative molybdopterin cofactor binding site [chemical binding]; other site 1206780000584 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1206780000585 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1206780000586 putative molybdopterin cofactor binding site; other site 1206780000587 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1206780000588 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1206780000589 active site 1206780000590 Zn binding site [ion binding]; other site 1206780000591 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1206780000592 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1206780000593 Predicted integral membrane protein [Function unknown]; Region: COG0392 1206780000594 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1206780000595 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1206780000596 MMPL family; Region: MMPL; pfam03176 1206780000597 MMPL family; Region: MMPL; pfam03176 1206780000598 LabA_like proteins; Region: LabA_like; cd06167 1206780000599 putative metal binding site [ion binding]; other site 1206780000600 Putative methyltransferase; Region: Methyltransf_4; pfam02390 1206780000601 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1206780000602 active site 1206780000603 substrate-binding site [chemical binding]; other site 1206780000604 metal-binding site [ion binding] 1206780000605 GTP binding site [chemical binding]; other site 1206780000606 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1206780000607 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1206780000608 active site 1206780000609 (T/H)XGH motif; other site 1206780000610 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1206780000611 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1206780000612 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1206780000613 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206780000614 FeS/SAM binding site; other site 1206780000615 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1206780000616 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780000617 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1206780000618 acyl-activating enzyme (AAE) consensus motif; other site 1206780000619 acyl-activating enzyme (AAE) consensus motif; other site 1206780000620 putative AMP binding site [chemical binding]; other site 1206780000621 putative active site [active] 1206780000622 putative CoA binding site [chemical binding]; other site 1206780000623 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780000624 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780000625 active site 1206780000626 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1206780000627 putative active site [active] 1206780000628 putative catalytic site [active] 1206780000629 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1206780000630 active site 2 [active] 1206780000631 active site 1 [active] 1206780000632 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1206780000633 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1206780000634 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1206780000635 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1206780000636 Moco binding site; other site 1206780000637 metal coordination site [ion binding]; other site 1206780000638 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1206780000639 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1206780000640 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1206780000641 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1206780000642 NAD(P) binding site [chemical binding]; other site 1206780000643 catalytic residues [active] 1206780000644 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1206780000645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780000646 S-adenosylmethionine binding site [chemical binding]; other site 1206780000647 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1206780000648 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206780000649 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1206780000650 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1206780000651 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1206780000652 putative active site [active] 1206780000653 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1206780000654 active site 1206780000655 substrate binding pocket [chemical binding]; other site 1206780000656 homodimer interaction site [polypeptide binding]; other site 1206780000657 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780000658 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1206780000659 active site 1206780000660 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780000661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780000662 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1206780000663 active site 1206780000664 diiron metal binding site [ion binding]; other site 1206780000665 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1206780000666 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1206780000667 NAD(P) binding site [chemical binding]; other site 1206780000668 catalytic residues [active] 1206780000669 Lipase maturation factor; Region: LMF1; pfam06762 1206780000670 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1206780000671 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1206780000672 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1206780000673 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1206780000674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780000675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780000676 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1206780000677 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1206780000678 MaoC like domain; Region: MaoC_dehydratas; pfam01575 1206780000679 active site 2 [active] 1206780000680 active site 1 [active] 1206780000681 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1206780000682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780000683 NAD(P) binding site [chemical binding]; other site 1206780000684 active site 1206780000685 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1206780000686 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1206780000687 dimer interface [polypeptide binding]; other site 1206780000688 active site 1206780000689 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1206780000690 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1206780000691 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1206780000692 FAD binding site [chemical binding]; other site 1206780000693 substrate binding site [chemical binding]; other site 1206780000694 catalytic residues [active] 1206780000695 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1206780000696 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1206780000697 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1206780000698 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1206780000699 catalytic loop [active] 1206780000700 iron binding site [ion binding]; other site 1206780000701 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1206780000702 L-aspartate oxidase; Provisional; Region: PRK06175 1206780000703 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1206780000704 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1206780000705 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1206780000706 putative dimer interface [polypeptide binding]; other site 1206780000707 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1206780000708 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206780000709 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1206780000710 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1206780000711 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1206780000712 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1206780000713 homotrimer interface [polypeptide binding]; other site 1206780000714 Walker A motif; other site 1206780000715 GTP binding site [chemical binding]; other site 1206780000716 Walker B motif; other site 1206780000717 cobyric acid synthase; Provisional; Region: PRK00784 1206780000718 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1206780000719 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1206780000720 catalytic triad [active] 1206780000721 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780000722 PPE family; Region: PPE; pfam00823 1206780000723 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1206780000724 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1206780000725 putative active site [active] 1206780000726 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1206780000727 putative active site [active] 1206780000728 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1206780000729 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1206780000730 active site 1206780000731 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1206780000732 DNA binding site [nucleotide binding] 1206780000733 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1206780000734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206780000735 Coenzyme A binding pocket [chemical binding]; other site 1206780000736 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 1206780000737 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1206780000738 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1206780000739 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1206780000740 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1206780000741 intersubunit interface [polypeptide binding]; other site 1206780000742 5-oxoprolinase; Region: PLN02666 1206780000743 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1206780000744 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1206780000745 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1206780000746 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1206780000747 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1206780000748 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1206780000749 nucleotide binding site [chemical binding]; other site 1206780000750 acyl-CoA synthetase; Validated; Region: PRK07788 1206780000751 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780000752 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780000753 active site 1206780000754 CoA binding site [chemical binding]; other site 1206780000755 AMP binding site [chemical binding]; other site 1206780000756 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780000757 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780000758 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1206780000759 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780000760 FAD binding site [chemical binding]; other site 1206780000761 substrate binding site [chemical binding]; other site 1206780000762 catalytic base [active] 1206780000763 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1206780000764 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780000765 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780000766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1206780000767 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1206780000768 putative active site [active] 1206780000769 PE family; Region: PE; pfam00934 1206780000770 PE family; Region: PE; pfam00934 1206780000771 PE family; Region: PE; pfam00934 1206780000772 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780000773 PPE family; Region: PPE; pfam00823 1206780000774 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780000775 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1206780000776 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1206780000777 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1206780000778 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780000779 Walker A motif; other site 1206780000780 ATP binding site [chemical binding]; other site 1206780000781 Walker B motif; other site 1206780000782 arginine finger; other site 1206780000783 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1206780000784 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1206780000785 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206780000786 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1206780000787 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206780000788 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206780000789 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780000790 PPE family; Region: PPE; pfam00823 1206780000791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1206780000792 EspG family; Region: ESX-1_EspG; pfam14011 1206780000793 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1206780000794 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1206780000795 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1206780000796 active site 1206780000797 catalytic residues [active] 1206780000798 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1206780000799 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1206780000800 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1206780000801 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1206780000802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780000803 S-adenosylmethionine binding site [chemical binding]; other site 1206780000804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 1206780000805 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1206780000806 Sulfatase; Region: Sulfatase; cl17466 1206780000807 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1206780000808 putative active site [active] 1206780000809 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780000810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780000811 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 1206780000812 protochlorophyllide reductase; Region: PLN00015 1206780000813 putative NAD(P) binding site [chemical binding]; other site 1206780000814 active site 1206780000815 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780000816 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780000817 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780000818 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780000819 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780000820 PPE family; Region: PPE; pfam00823 1206780000821 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780000822 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780000823 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780000824 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780000825 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780000826 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780000827 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780000828 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780000829 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780000830 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780000831 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1206780000832 putative FMN binding site [chemical binding]; other site 1206780000833 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1206780000834 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1206780000835 active site 1206780000836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1206780000837 SnoaL-like domain; Region: SnoaL_4; pfam13577 1206780000838 SnoaL-like domain; Region: SnoaL_3; pfam13474 1206780000839 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1206780000840 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1206780000841 nucleotide binding site [chemical binding]; other site 1206780000842 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 1206780000843 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1206780000844 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1206780000845 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1206780000846 active site 1206780000847 catalytic residues [active] 1206780000848 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 1206780000849 Muconolactone delta-isomerase; Region: MIase; cl01992 1206780000850 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1206780000851 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1206780000852 putative active site [active] 1206780000853 putative metal binding site [ion binding]; other site 1206780000854 catalytic site [active] 1206780000855 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1206780000856 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1206780000857 putative substrate binding pocket [chemical binding]; other site 1206780000858 AC domain interface; other site 1206780000859 catalytic triad [active] 1206780000860 AB domain interface; other site 1206780000861 interchain disulfide; other site 1206780000862 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1206780000863 trimer interface [polypeptide binding]; other site 1206780000864 active site 1206780000865 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1206780000866 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1206780000867 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1206780000868 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1206780000869 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1206780000870 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206780000871 dimerization interface [polypeptide binding]; other site 1206780000872 putative DNA binding site [nucleotide binding]; other site 1206780000873 putative Zn2+ binding site [ion binding]; other site 1206780000874 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1206780000875 active site residue [active] 1206780000876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780000877 S-adenosylmethionine binding site [chemical binding]; other site 1206780000878 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780000879 Cytochrome P450; Region: p450; cl12078 1206780000880 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1206780000881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780000882 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1206780000883 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206780000884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780000885 S-adenosylmethionine binding site [chemical binding]; other site 1206780000886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780000887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780000888 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1206780000889 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1206780000890 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1206780000891 SnoaL-like domain; Region: SnoaL_2; pfam12680 1206780000892 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1206780000893 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1206780000894 substrate binding site; other site 1206780000895 tetramer interface; other site 1206780000896 PE family; Region: PE; pfam00934 1206780000897 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780000898 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780000899 active site 1206780000900 aminotransferase AlaT; Validated; Region: PRK09265 1206780000901 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206780000902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780000903 homodimer interface [polypeptide binding]; other site 1206780000904 catalytic residue [active] 1206780000905 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1206780000906 4Fe-4S binding domain; Region: Fer4; pfam00037 1206780000907 Cysteine-rich domain; Region: CCG; pfam02754 1206780000908 Cysteine-rich domain; Region: CCG; pfam02754 1206780000909 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1206780000910 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1206780000911 DNA binding residues [nucleotide binding] 1206780000912 dimerization interface [polypeptide binding]; other site 1206780000913 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1206780000914 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1206780000915 G3 box; other site 1206780000916 Switch II region; other site 1206780000917 GTP/Mg2+ binding site [chemical binding]; other site 1206780000918 G4 box; other site 1206780000919 G5 box; other site 1206780000920 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1206780000921 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1206780000922 G1 box; other site 1206780000923 GTP/Mg2+ binding site [chemical binding]; other site 1206780000924 G2 box; other site 1206780000925 Switch I region; other site 1206780000926 G3 box; other site 1206780000927 Switch II region; other site 1206780000928 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 1206780000929 active site 1206780000930 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1206780000931 TIGR04255 family protein; Region: sporadTIGR04255 1206780000932 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1206780000933 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1206780000934 nucleotide binding site [chemical binding]; other site 1206780000935 NEF interaction site [polypeptide binding]; other site 1206780000936 SBD interface [polypeptide binding]; other site 1206780000937 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1206780000938 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1206780000939 dimer interface [polypeptide binding]; other site 1206780000940 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1206780000941 chaperone protein DnaJ; Provisional; Region: PRK14279 1206780000942 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1206780000943 HSP70 interaction site [polypeptide binding]; other site 1206780000944 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1206780000945 Zn binding sites [ion binding]; other site 1206780000946 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1206780000947 dimer interface [polypeptide binding]; other site 1206780000948 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1206780000949 DNA binding residues [nucleotide binding] 1206780000950 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1206780000951 putative dimer interface [polypeptide binding]; other site 1206780000952 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780000953 PPE family; Region: PPE; pfam00823 1206780000954 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780000955 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780000956 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780000957 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780000958 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780000959 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780000960 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780000961 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780000962 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780000963 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1206780000964 CoenzymeA binding site [chemical binding]; other site 1206780000965 subunit interaction site [polypeptide binding]; other site 1206780000966 PHB binding site; other site 1206780000967 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1206780000968 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1206780000969 GDP-binding site [chemical binding]; other site 1206780000970 ACT binding site; other site 1206780000971 IMP binding site; other site 1206780000972 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1206780000973 Peptidase family M50; Region: Peptidase_M50; pfam02163 1206780000974 active site 1206780000975 putative substrate binding region [chemical binding]; other site 1206780000976 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1206780000977 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1206780000978 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1206780000979 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1206780000980 Divalent cation transporter; Region: MgtE; pfam01769 1206780000981 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1206780000982 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 1206780000983 active site 1206780000984 intersubunit interface [polypeptide binding]; other site 1206780000985 zinc binding site [ion binding]; other site 1206780000986 Na+ binding site [ion binding]; other site 1206780000987 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1206780000988 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1206780000989 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 1206780000990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1206780000991 AAA domain; Region: AAA_33; pfam13671 1206780000992 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1206780000993 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1206780000994 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1206780000995 metal ion-dependent adhesion site (MIDAS); other site 1206780000996 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1206780000997 putative hydrophobic ligand binding site [chemical binding]; other site 1206780000998 MoxR-like ATPases [General function prediction only]; Region: COG0714 1206780000999 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1206780001000 Ligand binding site; other site 1206780001001 metal-binding site 1206780001002 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1206780001003 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1206780001004 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1206780001005 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1206780001006 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1206780001007 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1206780001008 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1206780001009 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1206780001010 catalytic loop [active] 1206780001011 iron binding site [ion binding]; other site 1206780001012 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1206780001013 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1206780001014 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1206780001015 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1206780001016 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1206780001017 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1206780001018 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1206780001019 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1206780001020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1206780001021 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1206780001022 dimerization interface [polypeptide binding]; other site 1206780001023 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1206780001024 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1206780001025 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1206780001026 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206780001027 active site 1206780001028 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1206780001029 Clp amino terminal domain; Region: Clp_N; pfam02861 1206780001030 Clp amino terminal domain; Region: Clp_N; pfam02861 1206780001031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780001032 Walker A motif; other site 1206780001033 ATP binding site [chemical binding]; other site 1206780001034 Walker B motif; other site 1206780001035 arginine finger; other site 1206780001036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780001037 Walker A motif; other site 1206780001038 ATP binding site [chemical binding]; other site 1206780001039 Walker B motif; other site 1206780001040 arginine finger; other site 1206780001041 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1206780001042 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1206780001043 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1206780001044 heme-binding site [chemical binding]; other site 1206780001045 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1206780001046 FAD binding pocket [chemical binding]; other site 1206780001047 FAD binding motif [chemical binding]; other site 1206780001048 phosphate binding motif [ion binding]; other site 1206780001049 beta-alpha-beta structure motif; other site 1206780001050 NAD binding pocket [chemical binding]; other site 1206780001051 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1206780001052 cyclase homology domain; Region: CHD; cd07302 1206780001053 nucleotidyl binding site; other site 1206780001054 metal binding site [ion binding]; metal-binding site 1206780001055 dimer interface [polypeptide binding]; other site 1206780001056 Predicted ATPase [General function prediction only]; Region: COG3903 1206780001057 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1206780001058 Walker A motif; other site 1206780001059 ATP binding site [chemical binding]; other site 1206780001060 Walker B motif; other site 1206780001061 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1206780001062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1206780001063 DNA binding residues [nucleotide binding] 1206780001064 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780001065 PPE family; Region: PPE; pfam00823 1206780001066 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 1206780001067 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1206780001068 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1206780001069 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1206780001070 active site residue [active] 1206780001071 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1206780001072 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1206780001073 homodimer interface [polypeptide binding]; other site 1206780001074 substrate-cofactor binding pocket; other site 1206780001075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780001076 catalytic residue [active] 1206780001077 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1206780001078 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206780001079 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206780001080 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780001081 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780001082 active site 1206780001083 PLD-like domain; Region: PLDc_2; pfam13091 1206780001084 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1206780001085 Beta-lactamase; Region: Beta-lactamase; pfam00144 1206780001086 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1206780001087 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780001088 FAD binding site [chemical binding]; other site 1206780001089 substrate binding pocket [chemical binding]; other site 1206780001090 catalytic base [active] 1206780001091 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1206780001092 MMPL family; Region: MMPL; pfam03176 1206780001093 MMPL family; Region: MMPL; pfam03176 1206780001094 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1206780001095 acyl-CoA synthetase; Validated; Region: PRK05850 1206780001096 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1206780001097 acyl-activating enzyme (AAE) consensus motif; other site 1206780001098 active site 1206780001099 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1206780001100 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1206780001101 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780001102 active site 1206780001103 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1206780001104 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1206780001105 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1206780001106 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780001107 Thioesterase; Region: PKS_TE; smart00824 1206780001108 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1206780001109 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1206780001110 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1206780001111 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1206780001112 phosphate acetyltransferase; Reviewed; Region: PRK05632 1206780001113 DRTGG domain; Region: DRTGG; pfam07085 1206780001114 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1206780001115 propionate/acetate kinase; Provisional; Region: PRK12379 1206780001116 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1206780001117 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1206780001118 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1206780001119 active site 1206780001120 ATP binding site [chemical binding]; other site 1206780001121 substrate binding site [chemical binding]; other site 1206780001122 activation loop (A-loop); other site 1206780001123 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1206780001124 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1206780001125 substrate binding pocket [chemical binding]; other site 1206780001126 membrane-bound complex binding site; other site 1206780001127 hinge residues; other site 1206780001128 NUDIX domain; Region: NUDIX; pfam00293 1206780001129 nudix motif; other site 1206780001130 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1206780001131 thiamine phosphate binding site [chemical binding]; other site 1206780001132 active site 1206780001133 pyrophosphate binding site [ion binding]; other site 1206780001134 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1206780001135 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1206780001136 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1206780001137 thiS-thiF/thiG interaction site; other site 1206780001138 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1206780001139 ThiS interaction site; other site 1206780001140 putative active site [active] 1206780001141 tetramer interface [polypeptide binding]; other site 1206780001142 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1206780001143 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1206780001144 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1206780001145 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1206780001146 PA/protease or protease-like domain interface [polypeptide binding]; other site 1206780001147 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1206780001148 active site 1206780001149 metal binding site [ion binding]; metal-binding site 1206780001150 Predicted metalloprotease [General function prediction only]; Region: COG2321 1206780001151 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1206780001152 Zn binding site [ion binding]; other site 1206780001153 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1206780001154 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1206780001155 dimer interface [polypeptide binding]; other site 1206780001156 substrate binding site [chemical binding]; other site 1206780001157 ATP binding site [chemical binding]; other site 1206780001158 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1206780001159 ThiC-associated domain; Region: ThiC-associated; pfam13667 1206780001160 ThiC family; Region: ThiC; pfam01964 1206780001161 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206780001162 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1206780001163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206780001164 motif II; other site 1206780001165 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1206780001166 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1206780001167 putative catalytic site [active] 1206780001168 putative phosphate binding site [ion binding]; other site 1206780001169 active site 1206780001170 metal binding site A [ion binding]; metal-binding site 1206780001171 DNA binding site [nucleotide binding] 1206780001172 putative AP binding site [nucleotide binding]; other site 1206780001173 putative metal binding site B [ion binding]; other site 1206780001174 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1206780001175 active site 1206780001176 catalytic residues [active] 1206780001177 metal binding site [ion binding]; metal-binding site 1206780001178 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1206780001179 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1206780001180 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1206780001181 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1206780001182 E-class dimer interface [polypeptide binding]; other site 1206780001183 P-class dimer interface [polypeptide binding]; other site 1206780001184 active site 1206780001185 Cu2+ binding site [ion binding]; other site 1206780001186 Zn2+ binding site [ion binding]; other site 1206780001187 carboxylate-amine ligase; Provisional; Region: PRK13517 1206780001188 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1206780001189 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1206780001190 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1206780001191 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1206780001192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780001193 Walker A motif; other site 1206780001194 ATP binding site [chemical binding]; other site 1206780001195 Walker B motif; other site 1206780001196 arginine finger; other site 1206780001197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780001198 Walker A motif; other site 1206780001199 ATP binding site [chemical binding]; other site 1206780001200 Walker B motif; other site 1206780001201 arginine finger; other site 1206780001202 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1206780001203 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1206780001204 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1206780001205 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1206780001206 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1206780001207 dimer interface [polypeptide binding]; other site 1206780001208 putative functional site; other site 1206780001209 putative MPT binding site; other site 1206780001210 short chain dehydrogenase; Provisional; Region: PRK06197 1206780001211 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1206780001212 putative NAD(P) binding site [chemical binding]; other site 1206780001213 active site 1206780001214 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1206780001215 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1206780001216 ring oligomerisation interface [polypeptide binding]; other site 1206780001217 ATP/Mg binding site [chemical binding]; other site 1206780001218 stacking interactions; other site 1206780001219 hinge regions; other site 1206780001220 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780001221 PPE family; Region: PPE; pfam00823 1206780001222 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1206780001223 DinB superfamily; Region: DinB_2; pfam12867 1206780001224 putative anti-sigmaE protein; Provisional; Region: PRK13920 1206780001225 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1206780001226 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1206780001227 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206780001228 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206780001229 DNA binding residues [nucleotide binding] 1206780001230 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 1206780001231 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1206780001232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780001233 S-adenosylmethionine binding site [chemical binding]; other site 1206780001234 Uncharacterized conserved protein [Function unknown]; Region: COG3496 1206780001235 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1206780001236 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 1206780001237 dimer interface [polypeptide binding]; other site 1206780001238 Transport protein; Region: actII; TIGR00833 1206780001239 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1206780001240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780001241 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780001242 PPE family; Region: PPE; pfam00823 1206780001243 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780001244 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1206780001245 enoyl-CoA hydratase; Provisional; Region: PRK12478 1206780001246 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780001247 substrate binding site [chemical binding]; other site 1206780001248 oxyanion hole (OAH) forming residues; other site 1206780001249 trimer interface [polypeptide binding]; other site 1206780001250 PemK-like protein; Region: PemK; pfam02452 1206780001251 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1206780001252 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1206780001253 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1206780001254 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1206780001255 NAD(P) binding site [chemical binding]; other site 1206780001256 catalytic residues [active] 1206780001257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 1206780001258 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1206780001259 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1206780001260 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206780001261 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1206780001262 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1206780001263 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1206780001264 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206780001265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206780001266 non-specific DNA binding site [nucleotide binding]; other site 1206780001267 salt bridge; other site 1206780001268 sequence-specific DNA binding site [nucleotide binding]; other site 1206780001269 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1206780001270 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1206780001271 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1206780001272 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1206780001273 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1206780001274 active site 1206780001275 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1206780001276 active site 2 [active] 1206780001277 isocitrate lyase; Provisional; Region: PRK15063 1206780001278 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 1206780001279 oligomerization interface [polypeptide binding]; other site 1206780001280 active site 1206780001281 metal binding site [ion binding]; metal-binding site 1206780001282 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1206780001283 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1206780001284 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1206780001285 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1206780001286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780001287 S-adenosylmethionine binding site [chemical binding]; other site 1206780001288 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1206780001289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206780001290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780001291 S-adenosylmethionine binding site [chemical binding]; other site 1206780001292 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1206780001293 UbiA prenyltransferase family; Region: UbiA; pfam01040 1206780001294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780001295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780001296 Predicted membrane protein [Function unknown]; Region: COG2733 1206780001297 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206780001298 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206780001299 non-specific DNA binding site [nucleotide binding]; other site 1206780001300 salt bridge; other site 1206780001301 sequence-specific DNA binding site [nucleotide binding]; other site 1206780001302 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1206780001303 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1206780001304 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1206780001305 intersubunit interface [polypeptide binding]; other site 1206780001306 active site 1206780001307 catalytic residue [active] 1206780001308 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1206780001309 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1206780001310 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1206780001311 putative active site [active] 1206780001312 catalytic triad [active] 1206780001313 putative dimer interface [polypeptide binding]; other site 1206780001314 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1206780001315 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1206780001316 FAD binding domain; Region: FAD_binding_4; pfam01565 1206780001317 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1206780001318 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1206780001319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1206780001320 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1206780001321 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1206780001322 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1206780001323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780001324 NAD(P) binding site [chemical binding]; other site 1206780001325 active site 1206780001326 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1206780001327 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1206780001328 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1206780001329 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1206780001330 putative ADP-binding pocket [chemical binding]; other site 1206780001331 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1206780001332 L-lysine exporter; Region: 2a75; TIGR00948 1206780001333 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206780001334 catalytic core [active] 1206780001335 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1206780001336 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206780001337 dimer interface [polypeptide binding]; other site 1206780001338 phosphorylation site [posttranslational modification] 1206780001339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206780001340 ATP binding site [chemical binding]; other site 1206780001341 Mg2+ binding site [ion binding]; other site 1206780001342 G-X-G motif; other site 1206780001343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206780001344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206780001345 active site 1206780001346 phosphorylation site [posttranslational modification] 1206780001347 intermolecular recognition site; other site 1206780001348 dimerization interface [polypeptide binding]; other site 1206780001349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206780001350 DNA binding site [nucleotide binding] 1206780001351 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1206780001352 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1206780001353 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1206780001354 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206780001355 DNA-binding site [nucleotide binding]; DNA binding site 1206780001356 FCD domain; Region: FCD; pfam07729 1206780001357 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1206780001358 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1206780001359 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1206780001360 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1206780001361 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1206780001362 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1206780001363 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1206780001364 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1206780001365 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1206780001366 DNA binding domain, excisionase family; Region: excise; TIGR01764 1206780001367 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1206780001368 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1206780001369 putative NAD(P) binding site [chemical binding]; other site 1206780001370 active site 1206780001371 putative substrate binding site [chemical binding]; other site 1206780001372 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1206780001373 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1206780001374 putative acyl-acceptor binding pocket; other site 1206780001375 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1206780001376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206780001377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780001378 S-adenosylmethionine binding site [chemical binding]; other site 1206780001379 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1206780001380 active site 1206780001381 catalytic site [active] 1206780001382 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1206780001383 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1206780001384 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1206780001385 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1206780001386 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1206780001387 glutamyl-tRNA reductase; Region: hemA; TIGR01035 1206780001388 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1206780001389 tRNA; other site 1206780001390 putative tRNA binding site [nucleotide binding]; other site 1206780001391 putative NADP binding site [chemical binding]; other site 1206780001392 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1206780001393 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1206780001394 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1206780001395 domain interfaces; other site 1206780001396 active site 1206780001397 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1206780001398 active site 1206780001399 homodimer interface [polypeptide binding]; other site 1206780001400 SAM binding site [chemical binding]; other site 1206780001401 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1206780001402 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1206780001403 active site 1206780001404 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1206780001405 dimer interface [polypeptide binding]; other site 1206780001406 active site 1206780001407 Schiff base residues; other site 1206780001408 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780001409 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780001410 active site 1206780001411 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1206780001412 anti sigma factor interaction site; other site 1206780001413 regulatory phosphorylation site [posttranslational modification]; other site 1206780001414 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1206780001415 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1206780001416 active site 1206780001417 catalytic triad [active] 1206780001418 oxyanion hole [active] 1206780001419 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1206780001420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780001421 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1206780001422 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1206780001423 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1206780001424 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1206780001425 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1206780001426 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206780001427 catalytic residue [active] 1206780001428 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206780001429 catalytic core [active] 1206780001430 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1206780001431 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1206780001432 catalytic residues [active] 1206780001433 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1206780001434 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1206780001435 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1206780001436 ResB-like family; Region: ResB; pfam05140 1206780001437 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1206780001438 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206780001439 AAA domain; Region: AAA_31; pfam13614 1206780001440 P-loop; other site 1206780001441 Magnesium ion binding site [ion binding]; other site 1206780001442 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1206780001443 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 1206780001444 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 1206780001445 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1206780001446 dimer interface [polypeptide binding]; other site 1206780001447 active site 1206780001448 CoA binding pocket [chemical binding]; other site 1206780001449 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1206780001450 UbiA prenyltransferase family; Region: UbiA; pfam01040 1206780001451 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1206780001452 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1206780001453 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780001454 NAD(P) binding site [chemical binding]; other site 1206780001455 active site 1206780001456 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1206780001457 Ligand binding site; other site 1206780001458 Putative Catalytic site; other site 1206780001459 DXD motif; other site 1206780001460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 1206780001461 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1206780001462 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780001463 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780001464 acyl-activating enzyme (AAE) consensus motif; other site 1206780001465 acyl-activating enzyme (AAE) consensus motif; other site 1206780001466 AMP binding site [chemical binding]; other site 1206780001467 active site 1206780001468 CoA binding site [chemical binding]; other site 1206780001469 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1206780001470 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1206780001471 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206780001472 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1206780001473 active site 1206780001474 short chain dehydrogenase; Provisional; Region: PRK05866 1206780001475 classical (c) SDRs; Region: SDR_c; cd05233 1206780001476 NAD(P) binding site [chemical binding]; other site 1206780001477 active site 1206780001478 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780001479 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1206780001480 substrate binding site [chemical binding]; other site 1206780001481 oxyanion hole (OAH) forming residues; other site 1206780001482 trimer interface [polypeptide binding]; other site 1206780001483 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1206780001484 putative active site [active] 1206780001485 homotetrameric interface [polypeptide binding]; other site 1206780001486 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 1206780001487 acyl-CoA synthetase; Validated; Region: PRK06188 1206780001488 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1206780001489 putative active site [active] 1206780001490 putative CoA binding site [chemical binding]; other site 1206780001491 putative AMP binding site [chemical binding]; other site 1206780001492 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1206780001493 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1206780001494 active site 1206780001495 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1206780001496 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1206780001497 active site 1206780001498 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206780001499 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1206780001500 TAP-like protein; Region: Abhydrolase_4; pfam08386 1206780001501 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1206780001502 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1206780001503 dimer interface [polypeptide binding]; other site 1206780001504 tetramer interface [polypeptide binding]; other site 1206780001505 PYR/PP interface [polypeptide binding]; other site 1206780001506 TPP binding site [chemical binding]; other site 1206780001507 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1206780001508 TPP-binding site; other site 1206780001509 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1206780001510 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206780001511 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1206780001512 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1206780001513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780001514 S-adenosylmethionine binding site [chemical binding]; other site 1206780001515 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1206780001516 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206780001517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780001518 S-adenosylmethionine binding site [chemical binding]; other site 1206780001519 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1206780001520 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1206780001521 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1206780001522 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1206780001523 substrate binding pocket [chemical binding]; other site 1206780001524 chain length determination region; other site 1206780001525 substrate-Mg2+ binding site; other site 1206780001526 catalytic residues [active] 1206780001527 aspartate-rich region 1; other site 1206780001528 active site lid residues [active] 1206780001529 aspartate-rich region 2; other site 1206780001530 heat shock protein HtpX; Provisional; Region: PRK03072 1206780001531 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1206780001532 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1206780001533 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1206780001534 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1206780001535 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1206780001536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1206780001537 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1206780001538 O-methyltransferase; Region: Methyltransf_2; pfam00891 1206780001539 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780001540 Cytochrome P450; Region: p450; cl12078 1206780001541 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1206780001542 ATP cone domain; Region: ATP-cone; pfam03477 1206780001543 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1206780001544 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1206780001545 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1206780001546 active site 1206780001547 dimer interface [polypeptide binding]; other site 1206780001548 effector binding site; other site 1206780001549 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1206780001550 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206780001551 active site 1206780001552 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1206780001553 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1206780001554 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 1206780001555 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1206780001556 active site 1206780001557 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1206780001558 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1206780001559 putative active site [active] 1206780001560 putative metal binding site [ion binding]; other site 1206780001561 hypothetical protein; Provisional; Region: PRK07588 1206780001562 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1206780001563 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206780001564 dimerization interface [polypeptide binding]; other site 1206780001565 putative DNA binding site [nucleotide binding]; other site 1206780001566 putative Zn2+ binding site [ion binding]; other site 1206780001567 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1206780001568 putative hydrophobic ligand binding site [chemical binding]; other site 1206780001569 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1206780001570 TIGR03086 family protein; Region: TIGR03086 1206780001571 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1206780001572 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206780001573 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1206780001574 PE family; Region: PE; pfam00934 1206780001575 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1206780001576 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1206780001577 Protein of unknown function DUF82; Region: DUF82; pfam01927 1206780001578 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1206780001579 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1206780001580 putative active site [active] 1206780001581 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1206780001582 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1206780001583 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1206780001584 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1206780001585 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1206780001586 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206780001587 DNA-binding site [nucleotide binding]; DNA binding site 1206780001588 FCD domain; Region: FCD; pfam07729 1206780001589 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1206780001590 Permease; Region: Permease; pfam02405 1206780001591 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1206780001592 Permease; Region: Permease; pfam02405 1206780001593 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780001594 mce related protein; Region: MCE; pfam02470 1206780001595 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1206780001596 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1206780001597 mce related protein; Region: MCE; pfam02470 1206780001598 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1206780001599 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780001600 mce related protein; Region: MCE; pfam02470 1206780001601 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780001602 mce related protein; Region: MCE; pfam02470 1206780001603 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1206780001604 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780001605 mce related protein; Region: MCE; pfam02470 1206780001606 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780001607 mce related protein; Region: MCE; pfam02470 1206780001608 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1206780001609 oligomeric interface; other site 1206780001610 putative active site [active] 1206780001611 homodimer interface [polypeptide binding]; other site 1206780001612 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1206780001613 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1206780001614 AAA domain; Region: AAA_14; pfam13173 1206780001615 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1206780001616 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1206780001617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1206780001618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206780001619 ATP binding site [chemical binding]; other site 1206780001620 Mg2+ binding site [ion binding]; other site 1206780001621 G-X-G motif; other site 1206780001622 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206780001623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206780001624 active site 1206780001625 phosphorylation site [posttranslational modification] 1206780001626 intermolecular recognition site; other site 1206780001627 dimerization interface [polypeptide binding]; other site 1206780001628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206780001629 DNA binding site [nucleotide binding] 1206780001630 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1206780001631 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1206780001632 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1206780001633 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1206780001634 catalytic residues [active] 1206780001635 catalytic nucleophile [active] 1206780001636 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1206780001637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1206780001638 Probable transposase; Region: OrfB_IS605; pfam01385 1206780001639 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1206780001640 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1206780001641 putative active site [active] 1206780001642 SEC-C motif; Region: SEC-C; pfam02810 1206780001643 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 1206780001644 putative active site [active] 1206780001645 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1206780001646 dimer interface [polypeptide binding]; other site 1206780001647 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1206780001648 active site 1206780001649 galactokinase; Provisional; Region: PRK00555 1206780001650 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1206780001651 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1206780001652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1206780001653 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1206780001654 putative active site [active] 1206780001655 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1206780001656 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1206780001657 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1206780001658 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1206780001659 oligomeric interface; other site 1206780001660 putative active site [active] 1206780001661 homodimer interface [polypeptide binding]; other site 1206780001662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1206780001663 FIST N domain; Region: FIST; pfam08495 1206780001664 FIST C domain; Region: FIST_C; pfam10442 1206780001665 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1206780001666 AAA domain; Region: AAA_30; pfam13604 1206780001667 Family description; Region: UvrD_C_2; pfam13538 1206780001668 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1206780001669 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1206780001670 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1206780001671 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1206780001672 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1206780001673 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780001674 substrate binding site [chemical binding]; other site 1206780001675 oxyanion hole (OAH) forming residues; other site 1206780001676 trimer interface [polypeptide binding]; other site 1206780001677 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1206780001678 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1206780001679 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1206780001680 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1206780001681 active site 1206780001682 catalytic site [active] 1206780001683 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1206780001684 active site 1206780001685 catalytic site [active] 1206780001686 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1206780001687 active site 1206780001688 catalytic site [active] 1206780001689 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1206780001690 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1206780001691 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1206780001692 putative homodimer interface [polypeptide binding]; other site 1206780001693 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1206780001694 heterodimer interface [polypeptide binding]; other site 1206780001695 homodimer interface [polypeptide binding]; other site 1206780001696 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1206780001697 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1206780001698 23S rRNA interface [nucleotide binding]; other site 1206780001699 L7/L12 interface [polypeptide binding]; other site 1206780001700 putative thiostrepton binding site; other site 1206780001701 L25 interface [polypeptide binding]; other site 1206780001702 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1206780001703 mRNA/rRNA interface [nucleotide binding]; other site 1206780001704 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1206780001705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780001706 S-adenosylmethionine binding site [chemical binding]; other site 1206780001707 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1206780001708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206780001709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780001710 S-adenosylmethionine binding site [chemical binding]; other site 1206780001711 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1206780001712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206780001713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780001714 S-adenosylmethionine binding site [chemical binding]; other site 1206780001715 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1206780001716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206780001717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780001718 S-adenosylmethionine binding site [chemical binding]; other site 1206780001719 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206780001720 TAP-like protein; Region: Abhydrolase_4; pfam08386 1206780001721 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1206780001722 ABC1 family; Region: ABC1; cl17513 1206780001723 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 1206780001724 active site 1206780001725 catalytic site [active] 1206780001726 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1206780001727 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1206780001728 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1206780001729 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1206780001730 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1206780001731 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1206780001732 23S rRNA interface [nucleotide binding]; other site 1206780001733 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1206780001734 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1206780001735 core dimer interface [polypeptide binding]; other site 1206780001736 peripheral dimer interface [polypeptide binding]; other site 1206780001737 L10 interface [polypeptide binding]; other site 1206780001738 L11 interface [polypeptide binding]; other site 1206780001739 putative EF-Tu interaction site [polypeptide binding]; other site 1206780001740 putative EF-G interaction site [polypeptide binding]; other site 1206780001741 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780001742 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780001743 WHG domain; Region: WHG; pfam13305 1206780001744 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1206780001745 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1206780001746 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1206780001747 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1206780001748 Walker A/P-loop; other site 1206780001749 ATP binding site [chemical binding]; other site 1206780001750 Q-loop/lid; other site 1206780001751 ABC transporter signature motif; other site 1206780001752 Walker B; other site 1206780001753 D-loop; other site 1206780001754 H-loop/switch region; other site 1206780001755 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1206780001756 putative active site [active] 1206780001757 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1206780001758 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1206780001759 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1206780001760 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 1206780001761 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1206780001762 Sulfatase; Region: Sulfatase; pfam00884 1206780001763 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1206780001764 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1206780001765 putative active site [active] 1206780001766 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1206780001767 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1206780001768 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1206780001769 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1206780001770 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1206780001771 RPB10 interaction site [polypeptide binding]; other site 1206780001772 RPB1 interaction site [polypeptide binding]; other site 1206780001773 RPB11 interaction site [polypeptide binding]; other site 1206780001774 RPB3 interaction site [polypeptide binding]; other site 1206780001775 RPB12 interaction site [polypeptide binding]; other site 1206780001776 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1206780001777 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1206780001778 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1206780001779 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1206780001780 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1206780001781 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1206780001782 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1206780001783 G-loop; other site 1206780001784 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1206780001785 DNA binding site [nucleotide binding] 1206780001786 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1206780001787 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1206780001788 endonuclease IV; Provisional; Region: PRK01060 1206780001789 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1206780001790 AP (apurinic/apyrimidinic) site pocket; other site 1206780001791 DNA interaction; other site 1206780001792 Metal-binding active site; metal-binding site 1206780001793 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1206780001794 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1206780001795 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1206780001796 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780001797 active site 1206780001798 enoyl-CoA hydratase; Provisional; Region: PRK12478 1206780001799 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780001800 substrate binding site [chemical binding]; other site 1206780001801 oxyanion hole (OAH) forming residues; other site 1206780001802 trimer interface [polypeptide binding]; other site 1206780001803 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 1206780001804 PaaX-like protein; Region: PaaX; pfam07848 1206780001805 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1206780001806 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1206780001807 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780001808 substrate binding site [chemical binding]; other site 1206780001809 oxyanion hole (OAH) forming residues; other site 1206780001810 trimer interface [polypeptide binding]; other site 1206780001811 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1206780001812 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1206780001813 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1206780001814 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1206780001815 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780001816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780001817 WHG domain; Region: WHG; pfam13305 1206780001818 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1206780001819 S17 interaction site [polypeptide binding]; other site 1206780001820 S8 interaction site; other site 1206780001821 16S rRNA interaction site [nucleotide binding]; other site 1206780001822 streptomycin interaction site [chemical binding]; other site 1206780001823 23S rRNA interaction site [nucleotide binding]; other site 1206780001824 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1206780001825 30S ribosomal protein S7; Validated; Region: PRK05302 1206780001826 elongation factor G; Reviewed; Region: PRK00007 1206780001827 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1206780001828 G1 box; other site 1206780001829 putative GEF interaction site [polypeptide binding]; other site 1206780001830 GTP/Mg2+ binding site [chemical binding]; other site 1206780001831 Switch I region; other site 1206780001832 G2 box; other site 1206780001833 G3 box; other site 1206780001834 Switch II region; other site 1206780001835 G4 box; other site 1206780001836 G5 box; other site 1206780001837 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1206780001838 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1206780001839 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1206780001840 elongation factor Tu; Reviewed; Region: PRK00049 1206780001841 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1206780001842 G1 box; other site 1206780001843 GEF interaction site [polypeptide binding]; other site 1206780001844 GTP/Mg2+ binding site [chemical binding]; other site 1206780001845 Switch I region; other site 1206780001846 G2 box; other site 1206780001847 G3 box; other site 1206780001848 Switch II region; other site 1206780001849 G4 box; other site 1206780001850 G5 box; other site 1206780001851 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1206780001852 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1206780001853 Antibiotic Binding Site [chemical binding]; other site 1206780001854 Short C-terminal domain; Region: SHOCT; pfam09851 1206780001855 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1206780001856 classical (c) SDRs; Region: SDR_c; cd05233 1206780001857 NAD(P) binding site [chemical binding]; other site 1206780001858 active site 1206780001859 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1206780001860 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206780001861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 1206780001862 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1206780001863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780001864 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1206780001865 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1206780001866 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206780001867 FeS/SAM binding site; other site 1206780001868 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1206780001869 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1206780001870 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1206780001871 phosphate binding site [ion binding]; other site 1206780001872 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1206780001873 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1206780001874 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1206780001875 Probable Catalytic site; other site 1206780001876 metal-binding site 1206780001877 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1206780001878 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1206780001879 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1206780001880 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1206780001881 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1206780001882 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1206780001883 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1206780001884 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1206780001885 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1206780001886 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1206780001887 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1206780001888 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1206780001889 putative translocon binding site; other site 1206780001890 protein-rRNA interface [nucleotide binding]; other site 1206780001891 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1206780001892 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1206780001893 G-X-X-G motif; other site 1206780001894 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1206780001895 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1206780001896 23S rRNA interface [nucleotide binding]; other site 1206780001897 5S rRNA interface [nucleotide binding]; other site 1206780001898 putative antibiotic binding site [chemical binding]; other site 1206780001899 L25 interface [polypeptide binding]; other site 1206780001900 L27 interface [polypeptide binding]; other site 1206780001901 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1206780001902 putative translocon interaction site; other site 1206780001903 23S rRNA interface [nucleotide binding]; other site 1206780001904 signal recognition particle (SRP54) interaction site; other site 1206780001905 L23 interface [polypeptide binding]; other site 1206780001906 trigger factor interaction site; other site 1206780001907 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1206780001908 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1206780001909 Sulfatase; Region: Sulfatase; pfam00884 1206780001910 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1206780001911 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1206780001912 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1206780001913 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1206780001914 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1206780001915 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1206780001916 RNA binding site [nucleotide binding]; other site 1206780001917 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1206780001918 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1206780001919 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1206780001920 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1206780001921 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1206780001922 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1206780001923 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1206780001924 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1206780001925 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1206780001926 5S rRNA interface [nucleotide binding]; other site 1206780001927 23S rRNA interface [nucleotide binding]; other site 1206780001928 L5 interface [polypeptide binding]; other site 1206780001929 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1206780001930 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1206780001931 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1206780001932 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1206780001933 23S rRNA binding site [nucleotide binding]; other site 1206780001934 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1206780001935 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1206780001936 tandem repeat interface [polypeptide binding]; other site 1206780001937 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1206780001938 oligomer interface [polypeptide binding]; other site 1206780001939 active site residues [active] 1206780001940 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1206780001941 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1206780001942 tandem repeat interface [polypeptide binding]; other site 1206780001943 oligomer interface [polypeptide binding]; other site 1206780001944 active site residues [active] 1206780001945 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1206780001946 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1206780001947 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1206780001948 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1206780001949 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1206780001950 intersubunit interface [polypeptide binding]; other site 1206780001951 active site 1206780001952 Zn2+ binding site [ion binding]; other site 1206780001953 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1206780001954 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1206780001955 NAD binding site [chemical binding]; other site 1206780001956 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1206780001957 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1206780001958 nucleotide binding site [chemical binding]; other site 1206780001959 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1206780001960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206780001961 Coenzyme A binding pocket [chemical binding]; other site 1206780001962 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1206780001963 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1206780001964 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1206780001965 SecY translocase; Region: SecY; pfam00344 1206780001966 adenylate kinase; Reviewed; Region: adk; PRK00279 1206780001967 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1206780001968 AMP-binding site [chemical binding]; other site 1206780001969 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1206780001970 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1206780001971 active site 1206780001972 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1206780001973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206780001974 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206780001975 DNA binding residues [nucleotide binding] 1206780001976 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1206780001977 Putative zinc-finger; Region: zf-HC2; pfam13490 1206780001978 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1206780001979 PYR/PP interface [polypeptide binding]; other site 1206780001980 MarR family; Region: MarR; pfam01047 1206780001981 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1206780001982 TIGR03086 family protein; Region: TIGR03086 1206780001983 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1206780001984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1206780001985 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1206780001986 Helix-turn-helix domain; Region: HTH_17; pfam12728 1206780001987 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1206780001988 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1206780001989 PE family; Region: PE; pfam00934 1206780001990 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1206780001991 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1206780001992 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1206780001993 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1206780001994 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780001995 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 1206780001996 substrate binding pocket [chemical binding]; other site 1206780001997 FAD binding site [chemical binding]; other site 1206780001998 catalytic base [active] 1206780001999 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1206780002000 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1206780002001 tetrameric interface [polypeptide binding]; other site 1206780002002 NAD binding site [chemical binding]; other site 1206780002003 catalytic residues [active] 1206780002004 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206780002005 catalytic core [active] 1206780002006 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780002007 PPE family; Region: PPE; pfam00823 1206780002008 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780002009 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780002010 Helix-turn-helix domain; Region: HTH_28; pfam13518 1206780002011 Winged helix-turn helix; Region: HTH_29; pfam13551 1206780002012 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206780002013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206780002014 active site 1206780002015 phosphorylation site [posttranslational modification] 1206780002016 intermolecular recognition site; other site 1206780002017 dimerization interface [polypeptide binding]; other site 1206780002018 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206780002019 DNA binding site [nucleotide binding] 1206780002020 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1206780002021 dimerization interface [polypeptide binding]; other site 1206780002022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206780002023 dimer interface [polypeptide binding]; other site 1206780002024 phosphorylation site [posttranslational modification] 1206780002025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206780002026 ATP binding site [chemical binding]; other site 1206780002027 Mg2+ binding site [ion binding]; other site 1206780002028 G-X-G motif; other site 1206780002029 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1206780002030 nucleotide binding site/active site [active] 1206780002031 HIT family signature motif; other site 1206780002032 catalytic residue [active] 1206780002033 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1206780002034 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1206780002035 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1206780002036 NAD binding site [chemical binding]; other site 1206780002037 catalytic Zn binding site [ion binding]; other site 1206780002038 substrate binding site [chemical binding]; other site 1206780002039 structural Zn binding site [ion binding]; other site 1206780002040 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1206780002041 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1206780002042 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1206780002043 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780002044 Cytochrome P450; Region: p450; cl12078 1206780002045 short chain dehydrogenase; Provisional; Region: PRK07775 1206780002046 classical (c) SDRs; Region: SDR_c; cd05233 1206780002047 NAD(P) binding site [chemical binding]; other site 1206780002048 active site 1206780002049 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780002050 Cytochrome P450; Region: p450; cl12078 1206780002051 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780002052 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1206780002053 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1206780002054 NAD binding site [chemical binding]; other site 1206780002055 catalytic residues [active] 1206780002056 short chain dehydrogenase; Provisional; Region: PRK07774 1206780002057 classical (c) SDRs; Region: SDR_c; cd05233 1206780002058 NAD(P) binding site [chemical binding]; other site 1206780002059 active site 1206780002060 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1206780002061 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1206780002062 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1206780002063 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1206780002064 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1206780002065 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1206780002066 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1206780002067 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1206780002068 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1206780002069 Predicted esterase [General function prediction only]; Region: COG0627 1206780002070 S-formylglutathione hydrolase; Region: PLN02442 1206780002071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1206780002072 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1206780002073 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 1206780002074 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1206780002075 tetramer interface [polypeptide binding]; other site 1206780002076 active site 1206780002077 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780002078 Cytochrome P450; Region: p450; cl12078 1206780002079 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1206780002080 ATP binding site [chemical binding]; other site 1206780002081 active site 1206780002082 substrate binding site [chemical binding]; other site 1206780002083 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1206780002084 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1206780002085 WHG domain; Region: WHG; pfam13305 1206780002086 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1206780002087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780002088 putative substrate translocation pore; other site 1206780002089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780002090 Predicted deacetylase [General function prediction only]; Region: COG3233 1206780002091 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1206780002092 putative active site [active] 1206780002093 putative Zn binding site [ion binding]; other site 1206780002094 FAD binding domain; Region: FAD_binding_2; pfam00890 1206780002095 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1206780002096 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1206780002097 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1206780002098 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1206780002099 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1206780002100 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1206780002101 putative active site [active] 1206780002102 catalytic triad [active] 1206780002103 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1206780002104 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1206780002105 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1206780002106 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1206780002107 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1206780002108 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1206780002109 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206780002110 DNA-binding site [nucleotide binding]; DNA binding site 1206780002111 UTRA domain; Region: UTRA; pfam07702 1206780002112 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1206780002113 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1206780002114 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1206780002115 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1206780002116 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1206780002117 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206780002118 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1206780002119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1206780002120 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1206780002121 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 1206780002122 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1206780002123 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1206780002124 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1206780002125 active site 1206780002126 metal binding site [ion binding]; metal-binding site 1206780002127 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1206780002128 active site 1206780002129 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206780002130 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1206780002131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1206780002132 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1206780002133 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1206780002134 dimerization interface [polypeptide binding]; other site 1206780002135 ATP binding site [chemical binding]; other site 1206780002136 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1206780002137 dimerization interface [polypeptide binding]; other site 1206780002138 ATP binding site [chemical binding]; other site 1206780002139 CAAX protease self-immunity; Region: Abi; pfam02517 1206780002140 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1206780002141 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1206780002142 active site 1206780002143 metal binding site [ion binding]; metal-binding site 1206780002144 hexamer interface [polypeptide binding]; other site 1206780002145 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1206780002146 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1206780002147 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1206780002148 active site 1206780002149 tetramer interface [polypeptide binding]; other site 1206780002150 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206780002151 active site 1206780002152 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 1206780002153 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1206780002154 dimerization interface [polypeptide binding]; other site 1206780002155 putative ATP binding site [chemical binding]; other site 1206780002156 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1206780002157 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1206780002158 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1206780002159 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1206780002160 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1206780002161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780002162 catalytic residue [active] 1206780002163 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1206780002164 heme-binding site [chemical binding]; other site 1206780002165 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1206780002166 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1206780002167 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1206780002168 active site residue [active] 1206780002169 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1206780002170 active site residue [active] 1206780002171 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1206780002172 catalytic residues [active] 1206780002173 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1206780002174 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206780002175 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206780002176 DNA binding site [nucleotide binding] 1206780002177 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1206780002178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206780002179 Coenzyme A binding pocket [chemical binding]; other site 1206780002180 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1206780002181 Walker A/P-loop; other site 1206780002182 ATP binding site [chemical binding]; other site 1206780002183 Q-loop/lid; other site 1206780002184 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1206780002185 PhoU domain; Region: PhoU; pfam01895 1206780002186 PhoU domain; Region: PhoU; pfam01895 1206780002187 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1206780002188 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1206780002189 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1206780002190 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1206780002191 FMN binding site [chemical binding]; other site 1206780002192 active site 1206780002193 catalytic residues [active] 1206780002194 substrate binding site [chemical binding]; other site 1206780002195 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1206780002196 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1206780002197 homodimer interface [polypeptide binding]; other site 1206780002198 putative substrate binding pocket [chemical binding]; other site 1206780002199 diiron center [ion binding]; other site 1206780002200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780002201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1206780002202 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206780002203 dimerization interface [polypeptide binding]; other site 1206780002204 putative DNA binding site [nucleotide binding]; other site 1206780002205 putative Zn2+ binding site [ion binding]; other site 1206780002206 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1206780002207 dimer interface [polypeptide binding]; other site 1206780002208 catalytic motif [active] 1206780002209 nucleoside/Zn binding site; other site 1206780002210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1206780002211 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1206780002212 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1206780002213 TIGR04255 family protein; Region: sporadTIGR04255 1206780002214 PE family; Region: PE; pfam00934 1206780002215 PE family; Region: PE; pfam00934 1206780002216 PknH-like extracellular domain; Region: PknH_C; pfam14032 1206780002217 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 1206780002218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 1206780002219 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 1206780002220 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1206780002221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780002222 S-adenosylmethionine binding site [chemical binding]; other site 1206780002223 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1206780002224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780002225 putative substrate translocation pore; other site 1206780002226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1206780002227 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1206780002228 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1206780002229 tetramer interface [polypeptide binding]; other site 1206780002230 TPP-binding site [chemical binding]; other site 1206780002231 heterodimer interface [polypeptide binding]; other site 1206780002232 phosphorylation loop region [posttranslational modification] 1206780002233 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1206780002234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206780002235 active site 1206780002236 phosphorylation site [posttranslational modification] 1206780002237 intermolecular recognition site; other site 1206780002238 dimerization interface [polypeptide binding]; other site 1206780002239 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1206780002240 DNA binding residues [nucleotide binding] 1206780002241 dimerization interface [polypeptide binding]; other site 1206780002242 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1206780002243 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1206780002244 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1206780002245 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1206780002246 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1206780002247 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1206780002248 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1206780002249 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1206780002250 dimer interface [polypeptide binding]; other site 1206780002251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780002252 catalytic residue [active] 1206780002253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780002254 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1206780002255 putative substrate translocation pore; other site 1206780002256 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1206780002257 short chain dehydrogenase; Provisional; Region: PRK05876 1206780002258 classical (c) SDRs; Region: SDR_c; cd05233 1206780002259 NAD(P) binding site [chemical binding]; other site 1206780002260 active site 1206780002261 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780002262 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1206780002263 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1206780002264 dimer interface [polypeptide binding]; other site 1206780002265 PYR/PP interface [polypeptide binding]; other site 1206780002266 TPP binding site [chemical binding]; other site 1206780002267 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1206780002268 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1206780002269 TPP-binding site [chemical binding]; other site 1206780002270 dimer interface [polypeptide binding]; other site 1206780002271 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1206780002272 putative hydrophobic ligand binding site [chemical binding]; other site 1206780002273 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1206780002274 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1206780002275 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1206780002276 putative hydrophobic ligand binding site [chemical binding]; other site 1206780002277 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1206780002278 putative hydrophobic ligand binding site [chemical binding]; other site 1206780002279 aminotransferase; Validated; Region: PRK07777 1206780002280 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206780002281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780002282 homodimer interface [polypeptide binding]; other site 1206780002283 catalytic residue [active] 1206780002284 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1206780002285 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1206780002286 dimer interface [polypeptide binding]; other site 1206780002287 active site 1206780002288 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1206780002289 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780002290 substrate binding site [chemical binding]; other site 1206780002291 oxyanion hole (OAH) forming residues; other site 1206780002292 trimer interface [polypeptide binding]; other site 1206780002293 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1206780002294 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1206780002295 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1206780002296 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1206780002297 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206780002298 ATP binding site [chemical binding]; other site 1206780002299 putative Mg++ binding site [ion binding]; other site 1206780002300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206780002301 nucleotide binding region [chemical binding]; other site 1206780002302 ATP-binding site [chemical binding]; other site 1206780002303 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1206780002304 WYL domain; Region: WYL; pfam13280 1206780002305 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1206780002306 trimer interface [polypeptide binding]; other site 1206780002307 dimer interface [polypeptide binding]; other site 1206780002308 putative active site [active] 1206780002309 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1206780002310 MPT binding site; other site 1206780002311 trimer interface [polypeptide binding]; other site 1206780002312 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1206780002313 MoaE homodimer interface [polypeptide binding]; other site 1206780002314 MoaD interaction [polypeptide binding]; other site 1206780002315 active site residues [active] 1206780002316 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1206780002317 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1206780002318 MoaE interaction surface [polypeptide binding]; other site 1206780002319 MoeB interaction surface [polypeptide binding]; other site 1206780002320 thiocarboxylated glycine; other site 1206780002321 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1206780002322 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206780002323 FeS/SAM binding site; other site 1206780002324 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1206780002325 hypothetical protein; Provisional; Region: PRK11770 1206780002326 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1206780002327 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1206780002328 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1206780002329 DNA-binding site [nucleotide binding]; DNA binding site 1206780002330 RNA-binding motif; other site 1206780002331 PE family; Region: PE; pfam00934 1206780002332 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780002333 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780002334 active site 1206780002335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1206780002336 FIST N domain; Region: FIST; pfam08495 1206780002337 FIST C domain; Region: FIST_C; pfam10442 1206780002338 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1206780002339 H+ Antiporter protein; Region: 2A0121; TIGR00900 1206780002340 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1206780002341 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780002342 PPE family; Region: PPE; pfam00823 1206780002343 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780002344 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780002345 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 1206780002346 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1206780002347 MarR family; Region: MarR; pfam01047 1206780002348 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1206780002349 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1206780002350 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1206780002351 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1206780002352 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1206780002353 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 1206780002354 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206780002355 catalytic residue [active] 1206780002356 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1206780002357 Ferredoxin [Energy production and conversion]; Region: COG1146 1206780002358 4Fe-4S binding domain; Region: Fer4; pfam00037 1206780002359 ferredoxin-NADP+ reductase; Region: PLN02852 1206780002360 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1206780002361 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1206780002362 putative dimer interface [polypeptide binding]; other site 1206780002363 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206780002364 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1206780002365 putative catalytic site [active] 1206780002366 putative phosphate binding site [ion binding]; other site 1206780002367 putative metal binding site [ion binding]; other site 1206780002368 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1206780002369 dimer interface [polypeptide binding]; other site 1206780002370 Citrate synthase; Region: Citrate_synt; pfam00285 1206780002371 active site 1206780002372 citrylCoA binding site [chemical binding]; other site 1206780002373 oxalacetate/citrate binding site [chemical binding]; other site 1206780002374 coenzyme A binding site [chemical binding]; other site 1206780002375 catalytic triad [active] 1206780002376 Predicted ATPase [General function prediction only]; Region: COG3903 1206780002377 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1206780002378 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1206780002379 DNA binding residues [nucleotide binding] 1206780002380 dimerization interface [polypeptide binding]; other site 1206780002381 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1206780002382 cyclase homology domain; Region: CHD; cd07302 1206780002383 nucleotidyl binding site; other site 1206780002384 metal binding site [ion binding]; metal-binding site 1206780002385 dimer interface [polypeptide binding]; other site 1206780002386 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1206780002387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1206780002388 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1206780002389 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1206780002390 AAA ATPase domain; Region: AAA_16; pfam13191 1206780002391 Predicted ATPase [General function prediction only]; Region: COG3903 1206780002392 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1206780002393 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1206780002394 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1206780002395 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1206780002396 dimer interface [polypeptide binding]; other site 1206780002397 active site 1206780002398 citrylCoA binding site [chemical binding]; other site 1206780002399 NADH binding [chemical binding]; other site 1206780002400 cationic pore residues; other site 1206780002401 oxalacetate/citrate binding site [chemical binding]; other site 1206780002402 coenzyme A binding site [chemical binding]; other site 1206780002403 catalytic triad [active] 1206780002404 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1206780002405 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1206780002406 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1206780002407 BON domain; Region: BON; pfam04972 1206780002408 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1206780002409 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1206780002410 ligand binding site [chemical binding]; other site 1206780002411 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1206780002412 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1206780002413 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1206780002414 dimerization interface [polypeptide binding]; other site 1206780002415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206780002416 dimer interface [polypeptide binding]; other site 1206780002417 phosphorylation site [posttranslational modification] 1206780002418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206780002419 Mg2+ binding site [ion binding]; other site 1206780002420 G-X-G motif; other site 1206780002421 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206780002422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206780002423 active site 1206780002424 phosphorylation site [posttranslational modification] 1206780002425 intermolecular recognition site; other site 1206780002426 dimerization interface [polypeptide binding]; other site 1206780002427 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206780002428 DNA binding site [nucleotide binding] 1206780002429 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1206780002430 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 1206780002431 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1206780002432 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780002433 substrate binding site [chemical binding]; other site 1206780002434 oxyanion hole (OAH) forming residues; other site 1206780002435 trimer interface [polypeptide binding]; other site 1206780002436 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1206780002437 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1206780002438 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1206780002439 Beta-lactamase; Region: Beta-lactamase; pfam00144 1206780002440 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1206780002441 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1206780002442 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206780002443 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1206780002444 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1206780002445 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1206780002446 hydrophobic ligand binding site; other site 1206780002447 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1206780002448 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206780002449 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1206780002450 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206780002451 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1206780002452 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1206780002453 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1206780002454 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 1206780002455 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1206780002456 active site 1206780002457 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780002458 PPE family; Region: PPE; pfam00823 1206780002459 PE family; Region: PE; pfam00934 1206780002460 BCCT family transporter; Region: BCCT; pfam02028 1206780002461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1206780002462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206780002463 Coenzyme A binding pocket [chemical binding]; other site 1206780002464 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1206780002465 MULE transposase domain; Region: MULE; pfam10551 1206780002466 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1206780002467 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1206780002468 catalytic residues [active] 1206780002469 catalytic nucleophile [active] 1206780002470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1206780002471 Probable transposase; Region: OrfB_IS605; pfam01385 1206780002472 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1206780002473 putative active site pocket [active] 1206780002474 dimerization interface [polypeptide binding]; other site 1206780002475 putative catalytic residue [active] 1206780002476 Phage-related replication protein [General function prediction only]; Region: COG4195 1206780002477 manganese transport protein MntH; Reviewed; Region: PRK00701 1206780002478 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1206780002479 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1206780002480 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1206780002481 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1206780002482 short chain dehydrogenase; Provisional; Region: PRK07814 1206780002483 classical (c) SDRs; Region: SDR_c; cd05233 1206780002484 NAD(P) binding site [chemical binding]; other site 1206780002485 active site 1206780002486 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1206780002487 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1206780002488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780002489 dimer interface [polypeptide binding]; other site 1206780002490 conserved gate region; other site 1206780002491 putative PBP binding loops; other site 1206780002492 ABC-ATPase subunit interface; other site 1206780002493 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1206780002494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780002495 dimer interface [polypeptide binding]; other site 1206780002496 conserved gate region; other site 1206780002497 putative PBP binding loops; other site 1206780002498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1206780002499 ABC-ATPase subunit interface; other site 1206780002500 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1206780002501 NHL repeat; Region: NHL; pfam01436 1206780002502 NHL repeat; Region: NHL; pfam01436 1206780002503 NHL repeat; Region: NHL; pfam01436 1206780002504 NHL repeat; Region: NHL; pfam01436 1206780002505 NHL repeat; Region: NHL; pfam01436 1206780002506 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1206780002507 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1206780002508 active site 1206780002509 ATP binding site [chemical binding]; other site 1206780002510 substrate binding site [chemical binding]; other site 1206780002511 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1206780002512 substrate binding site [chemical binding]; other site 1206780002513 activation loop (A-loop); other site 1206780002514 activation loop (A-loop); other site 1206780002515 PBP superfamily domain; Region: PBP_like_2; cl17296 1206780002516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206780002517 Walker A/P-loop; other site 1206780002518 ATP binding site [chemical binding]; other site 1206780002519 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1206780002520 Q-loop/lid; other site 1206780002521 ABC transporter signature motif; other site 1206780002522 Walker B; other site 1206780002523 D-loop; other site 1206780002524 H-loop/switch region; other site 1206780002525 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1206780002526 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1206780002527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780002528 dimer interface [polypeptide binding]; other site 1206780002529 conserved gate region; other site 1206780002530 putative PBP binding loops; other site 1206780002531 ABC-ATPase subunit interface; other site 1206780002532 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1206780002533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780002534 dimer interface [polypeptide binding]; other site 1206780002535 conserved gate region; other site 1206780002536 putative PBP binding loops; other site 1206780002537 ABC-ATPase subunit interface; other site 1206780002538 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1206780002539 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1206780002540 putative DNA binding site [nucleotide binding]; other site 1206780002541 putative homodimer interface [polypeptide binding]; other site 1206780002542 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1206780002543 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1206780002544 nucleotide binding site [chemical binding]; other site 1206780002545 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1206780002546 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1206780002547 active site 1206780002548 DNA binding site [nucleotide binding] 1206780002549 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1206780002550 DNA binding site [nucleotide binding] 1206780002551 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1206780002552 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1206780002553 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1206780002554 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1206780002555 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1206780002556 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1206780002557 anti sigma factor interaction site; other site 1206780002558 regulatory phosphorylation site [posttranslational modification]; other site 1206780002559 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1206780002560 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1206780002561 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1206780002562 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1206780002563 short chain dehydrogenase; Provisional; Region: PRK08251 1206780002564 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1206780002565 putative NAD(P) binding site [chemical binding]; other site 1206780002566 active site 1206780002567 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1206780002568 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1206780002569 active site 1206780002570 dimer interface [polypeptide binding]; other site 1206780002571 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1206780002572 dimer interface [polypeptide binding]; other site 1206780002573 active site 1206780002574 Predicted esterase [General function prediction only]; Region: COG0627 1206780002575 hypothetical protein; Provisional; Region: PRK07857 1206780002576 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1206780002577 Part of AAA domain; Region: AAA_19; pfam13245 1206780002578 Family description; Region: UvrD_C_2; pfam13538 1206780002579 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1206780002580 Peptidase family M23; Region: Peptidase_M23; pfam01551 1206780002581 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1206780002582 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1206780002583 CoA-ligase; Region: Ligase_CoA; pfam00549 1206780002584 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1206780002585 CoA binding domain; Region: CoA_binding; smart00881 1206780002586 CoA-ligase; Region: Ligase_CoA; pfam00549 1206780002587 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1206780002588 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1206780002589 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1206780002590 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1206780002591 active site 1206780002592 substrate binding site [chemical binding]; other site 1206780002593 cosubstrate binding site; other site 1206780002594 catalytic site [active] 1206780002595 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1206780002596 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1206780002597 purine monophosphate binding site [chemical binding]; other site 1206780002598 dimer interface [polypeptide binding]; other site 1206780002599 putative catalytic residues [active] 1206780002600 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1206780002601 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1206780002602 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1206780002603 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1206780002604 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1206780002605 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1206780002606 metal ion-dependent adhesion site (MIDAS); other site 1206780002607 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1206780002608 homotetrameric interface [polypeptide binding]; other site 1206780002609 putative active site [active] 1206780002610 metal binding site [ion binding]; metal-binding site 1206780002611 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1206780002612 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1206780002613 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 1206780002614 putative homodimer interface [polypeptide binding]; other site 1206780002615 putative homotetramer interface [polypeptide binding]; other site 1206780002616 allosteric switch controlling residues; other site 1206780002617 putative metal binding site [ion binding]; other site 1206780002618 putative homodimer-homodimer interface [polypeptide binding]; other site 1206780002619 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1206780002620 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1206780002621 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206780002622 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1206780002623 enoyl-CoA hydratase; Provisional; Region: PRK07827 1206780002624 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780002625 substrate binding site [chemical binding]; other site 1206780002626 oxyanion hole (OAH) forming residues; other site 1206780002627 trimer interface [polypeptide binding]; other site 1206780002628 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780002629 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1206780002630 active site 1206780002631 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1206780002632 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1206780002633 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1206780002634 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1206780002635 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1206780002636 carboxyltransferase (CT) interaction site; other site 1206780002637 biotinylation site [posttranslational modification]; other site 1206780002638 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1206780002639 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1206780002640 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780002641 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780002642 active site 1206780002643 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1206780002644 PE family; Region: PE; pfam00934 1206780002645 PE family; Region: PE; pfam00934 1206780002646 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1206780002647 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1206780002648 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1206780002649 PE family; Region: PE; pfam00934 1206780002650 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1206780002651 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1206780002652 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1206780002653 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1206780002654 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206780002655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206780002656 active site 1206780002657 phosphorylation site [posttranslational modification] 1206780002658 intermolecular recognition site; other site 1206780002659 dimerization interface [polypeptide binding]; other site 1206780002660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206780002661 DNA binding site [nucleotide binding] 1206780002662 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1206780002663 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1206780002664 dimerization interface [polypeptide binding]; other site 1206780002665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206780002666 dimer interface [polypeptide binding]; other site 1206780002667 phosphorylation site [posttranslational modification] 1206780002668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206780002669 ATP binding site [chemical binding]; other site 1206780002670 Mg2+ binding site [ion binding]; other site 1206780002671 G-X-G motif; other site 1206780002672 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1206780002673 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1206780002674 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1206780002675 MPT binding site; other site 1206780002676 trimer interface [polypeptide binding]; other site 1206780002677 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1206780002678 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1206780002679 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206780002680 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1206780002681 Walker A/P-loop; other site 1206780002682 ATP binding site [chemical binding]; other site 1206780002683 Q-loop/lid; other site 1206780002684 ABC transporter signature motif; other site 1206780002685 Walker B; other site 1206780002686 D-loop; other site 1206780002687 H-loop/switch region; other site 1206780002688 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1206780002689 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1206780002690 FtsX-like permease family; Region: FtsX; pfam02687 1206780002691 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1206780002692 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1206780002693 FtsX-like permease family; Region: FtsX; pfam02687 1206780002694 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 1206780002695 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1206780002696 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1206780002697 substrate binding pocket [chemical binding]; other site 1206780002698 chain length determination region; other site 1206780002699 substrate-Mg2+ binding site; other site 1206780002700 catalytic residues [active] 1206780002701 aspartate-rich region 1; other site 1206780002702 active site lid residues [active] 1206780002703 aspartate-rich region 2; other site 1206780002704 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1206780002705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 1206780002706 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1206780002707 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1206780002708 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1206780002709 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1206780002710 active site 1206780002711 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1206780002712 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1206780002713 dimer interface [polypeptide binding]; other site 1206780002714 putative functional site; other site 1206780002715 putative MPT binding site; other site 1206780002716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1206780002717 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1206780002718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780002719 S-adenosylmethionine binding site [chemical binding]; other site 1206780002720 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1206780002721 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1206780002722 ligand binding site [chemical binding]; other site 1206780002723 flexible hinge region; other site 1206780002724 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1206780002725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206780002726 Coenzyme A binding pocket [chemical binding]; other site 1206780002727 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1206780002728 arginine deiminase; Provisional; Region: PRK01388 1206780002729 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1206780002730 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1206780002731 Predicted methyltransferases [General function prediction only]; Region: COG0313 1206780002732 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1206780002733 putative SAM binding site [chemical binding]; other site 1206780002734 putative homodimer interface [polypeptide binding]; other site 1206780002735 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1206780002736 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1206780002737 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1206780002738 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1206780002739 active site 1206780002740 HIGH motif; other site 1206780002741 KMSKS motif; other site 1206780002742 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1206780002743 tRNA binding surface [nucleotide binding]; other site 1206780002744 anticodon binding site; other site 1206780002745 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1206780002746 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1206780002747 active site 1206780002748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1206780002749 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1206780002750 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1206780002751 G5 domain; Region: G5; pfam07501 1206780002752 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1206780002753 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1206780002754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780002755 S-adenosylmethionine binding site [chemical binding]; other site 1206780002756 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1206780002757 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 1206780002758 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1206780002759 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1206780002760 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780002761 acyl-activating enzyme (AAE) consensus motif; other site 1206780002762 AMP binding site [chemical binding]; other site 1206780002763 active site 1206780002764 CoA binding site [chemical binding]; other site 1206780002765 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1206780002766 putative active site [active] 1206780002767 catalytic residue [active] 1206780002768 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1206780002769 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1206780002770 5S rRNA interface [nucleotide binding]; other site 1206780002771 CTC domain interface [polypeptide binding]; other site 1206780002772 L16 interface [polypeptide binding]; other site 1206780002773 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1206780002774 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1206780002775 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1206780002776 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206780002777 active site 1206780002778 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1206780002779 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1206780002780 Substrate binding site; other site 1206780002781 Mg++ binding site; other site 1206780002782 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1206780002783 active site 1206780002784 substrate binding site [chemical binding]; other site 1206780002785 CoA binding site [chemical binding]; other site 1206780002786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780002787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780002788 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1206780002789 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1206780002790 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206780002791 ATP binding site [chemical binding]; other site 1206780002792 putative Mg++ binding site [ion binding]; other site 1206780002793 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206780002794 nucleotide binding region [chemical binding]; other site 1206780002795 ATP-binding site [chemical binding]; other site 1206780002796 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1206780002797 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1206780002798 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1206780002799 homodimer interface [polypeptide binding]; other site 1206780002800 metal binding site [ion binding]; metal-binding site 1206780002801 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1206780002802 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1206780002803 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1206780002804 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1206780002805 enolase; Provisional; Region: eno; PRK00077 1206780002806 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1206780002807 dimer interface [polypeptide binding]; other site 1206780002808 metal binding site [ion binding]; metal-binding site 1206780002809 substrate binding pocket [chemical binding]; other site 1206780002810 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1206780002811 Septum formation initiator; Region: DivIC; pfam04977 1206780002812 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1206780002813 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1206780002814 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1206780002815 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1206780002816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206780002817 active site 1206780002818 phosphorylation site [posttranslational modification] 1206780002819 intermolecular recognition site; other site 1206780002820 dimerization interface [polypeptide binding]; other site 1206780002821 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206780002822 DNA binding site [nucleotide binding] 1206780002823 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1206780002824 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1206780002825 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1206780002826 Ligand Binding Site [chemical binding]; other site 1206780002827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206780002828 dimer interface [polypeptide binding]; other site 1206780002829 phosphorylation site [posttranslational modification] 1206780002830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206780002831 ATP binding site [chemical binding]; other site 1206780002832 Mg2+ binding site [ion binding]; other site 1206780002833 G-X-G motif; other site 1206780002834 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 1206780002835 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1206780002836 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206780002837 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1206780002838 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 1206780002839 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1206780002840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206780002841 dimer interface [polypeptide binding]; other site 1206780002842 phosphorylation site [posttranslational modification] 1206780002843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206780002844 ATP binding site [chemical binding]; other site 1206780002845 Mg2+ binding site [ion binding]; other site 1206780002846 G-X-G motif; other site 1206780002847 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206780002848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206780002849 active site 1206780002850 phosphorylation site [posttranslational modification] 1206780002851 intermolecular recognition site; other site 1206780002852 dimerization interface [polypeptide binding]; other site 1206780002853 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206780002854 DNA binding site [nucleotide binding] 1206780002855 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1206780002856 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1206780002857 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1206780002858 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1206780002859 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1206780002860 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780002861 PPE family; Region: PPE; pfam00823 1206780002862 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780002863 PE family; Region: PE; pfam00934 1206780002864 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780002865 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1206780002866 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1206780002867 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1206780002868 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1206780002869 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1206780002870 Predicted transcriptional regulator [Transcription]; Region: COG5340 1206780002871 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1206780002872 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1206780002873 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1206780002874 MULE transposase domain; Region: MULE; pfam10551 1206780002875 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1206780002876 MarR family; Region: MarR_2; pfam12802 1206780002877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780002878 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1206780002879 NAD(P) binding site [chemical binding]; other site 1206780002880 active site 1206780002881 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1206780002882 Helix-turn-helix domain; Region: HTH_17; pfam12728 1206780002883 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1206780002884 Domain of unknown function (DUF427); Region: DUF427; cl00998 1206780002885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1206780002886 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780002887 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1206780002888 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1206780002889 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1206780002890 dimer interface [polypeptide binding]; other site 1206780002891 acyl-activating enzyme (AAE) consensus motif; other site 1206780002892 putative active site [active] 1206780002893 AMP binding site [chemical binding]; other site 1206780002894 putative CoA binding site [chemical binding]; other site 1206780002895 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1206780002896 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1206780002897 hydrophobic ligand binding site; other site 1206780002898 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1206780002899 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1206780002900 putative active site [active] 1206780002901 putative dimer interface [polypeptide binding]; other site 1206780002902 Patatin-like phospholipase; Region: Patatin; pfam01734 1206780002903 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1206780002904 nucleophile elbow; other site 1206780002905 hypothetical protein; Provisional; Region: PRK10279 1206780002906 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1206780002907 active site 1206780002908 nucleophile elbow; other site 1206780002909 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1206780002910 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1206780002911 active site residue [active] 1206780002912 PE family; Region: PE; pfam00934 1206780002913 PE family; Region: PE; pfam00934 1206780002914 Predicted membrane protein [Function unknown]; Region: COG4425 1206780002915 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1206780002916 enoyl-CoA hydratase; Provisional; Region: PRK05862 1206780002917 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780002918 substrate binding site [chemical binding]; other site 1206780002919 oxyanion hole (OAH) forming residues; other site 1206780002920 trimer interface [polypeptide binding]; other site 1206780002921 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1206780002922 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780002923 substrate binding site [chemical binding]; other site 1206780002924 oxyanion hole (OAH) forming residues; other site 1206780002925 trimer interface [polypeptide binding]; other site 1206780002926 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1206780002927 Predicted membrane protein [Function unknown]; Region: COG4760 1206780002928 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1206780002929 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1206780002930 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1206780002931 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1206780002932 dimer interface [polypeptide binding]; other site 1206780002933 active site 1206780002934 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1206780002935 active site 1206780002936 catalytic triad [active] 1206780002937 oxyanion hole [active] 1206780002938 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1206780002939 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1206780002940 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1206780002941 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1206780002942 dimer interface [polypeptide binding]; other site 1206780002943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780002944 catalytic residue [active] 1206780002945 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1206780002946 RDD family; Region: RDD; pfam06271 1206780002947 cystathionine gamma-synthase; Provisional; Region: PRK07811 1206780002948 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1206780002949 homodimer interface [polypeptide binding]; other site 1206780002950 substrate-cofactor binding pocket; other site 1206780002951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780002952 catalytic residue [active] 1206780002953 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1206780002954 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1206780002955 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1206780002956 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1206780002957 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1206780002958 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1206780002959 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1206780002960 catalytic residues [active] 1206780002961 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1206780002962 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1206780002963 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1206780002964 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1206780002965 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1206780002966 catalytic residue [active] 1206780002967 putative FPP diphosphate binding site; other site 1206780002968 putative FPP binding hydrophobic cleft; other site 1206780002969 dimer interface [polypeptide binding]; other site 1206780002970 putative IPP diphosphate binding site; other site 1206780002971 PE family; Region: PE; pfam00934 1206780002972 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1206780002973 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1206780002974 putative IPP diphosphate binding site; other site 1206780002975 PE family; Region: PE; pfam00934 1206780002976 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 1206780002977 PE family; Region: PE; pfam00934 1206780002978 pantothenate kinase; Provisional; Region: PRK05439 1206780002979 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1206780002980 ATP-binding site [chemical binding]; other site 1206780002981 CoA-binding site [chemical binding]; other site 1206780002982 Mg2+-binding site [ion binding]; other site 1206780002983 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1206780002984 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1206780002985 dimer interface [polypeptide binding]; other site 1206780002986 active site 1206780002987 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1206780002988 folate binding site [chemical binding]; other site 1206780002989 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1206780002990 dinuclear metal binding motif [ion binding]; other site 1206780002991 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1206780002992 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1206780002993 putative active site [active] 1206780002994 PhoH-like protein; Region: PhoH; pfam02562 1206780002995 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1206780002996 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1206780002997 NodB motif; other site 1206780002998 active site 1206780002999 catalytic site [active] 1206780003000 metal binding site [ion binding]; metal-binding site 1206780003001 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1206780003002 Class II fumarases; Region: Fumarase_classII; cd01362 1206780003003 active site 1206780003004 tetramer interface [polypeptide binding]; other site 1206780003005 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1206780003006 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1206780003007 putative active site [active] 1206780003008 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1206780003009 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1206780003010 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1206780003011 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1206780003012 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1206780003013 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1206780003014 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1206780003015 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1206780003016 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1206780003017 putative NAD(P) binding site [chemical binding]; other site 1206780003018 active site 1206780003019 putative substrate binding site [chemical binding]; other site 1206780003020 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 1206780003021 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1206780003022 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1206780003023 generic binding surface II; other site 1206780003024 generic binding surface I; other site 1206780003025 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1206780003026 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1206780003027 Yip1 domain; Region: Yip1; pfam04893 1206780003028 GTP-binding protein YchF; Reviewed; Region: PRK09601 1206780003029 YchF GTPase; Region: YchF; cd01900 1206780003030 G1 box; other site 1206780003031 GTP/Mg2+ binding site [chemical binding]; other site 1206780003032 Switch I region; other site 1206780003033 G2 box; other site 1206780003034 Switch II region; other site 1206780003035 G3 box; other site 1206780003036 G4 box; other site 1206780003037 G5 box; other site 1206780003038 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1206780003039 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1206780003040 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1206780003041 putative active site [active] 1206780003042 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1206780003043 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1206780003044 cyclase homology domain; Region: CHD; cd07302 1206780003045 nucleotidyl binding site; other site 1206780003046 metal binding site [ion binding]; metal-binding site 1206780003047 dimer interface [polypeptide binding]; other site 1206780003048 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 1206780003049 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1206780003050 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1206780003051 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1206780003052 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1206780003053 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1206780003054 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206780003055 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1206780003056 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1206780003057 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1206780003058 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1206780003059 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780003060 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780003061 active site 1206780003062 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206780003063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206780003064 non-specific DNA binding site [nucleotide binding]; other site 1206780003065 salt bridge; other site 1206780003066 sequence-specific DNA binding site [nucleotide binding]; other site 1206780003067 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1206780003068 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1206780003069 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1206780003070 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1206780003071 citrate synthase; Provisional; Region: PRK14033 1206780003072 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1206780003073 oxalacetate binding site [chemical binding]; other site 1206780003074 citrylCoA binding site [chemical binding]; other site 1206780003075 coenzyme A binding site [chemical binding]; other site 1206780003076 catalytic triad [active] 1206780003077 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1206780003078 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1206780003079 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1206780003080 THF binding site; other site 1206780003081 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1206780003082 substrate binding site [chemical binding]; other site 1206780003083 THF binding site; other site 1206780003084 zinc-binding site [ion binding]; other site 1206780003085 PPE family; Region: PPE; pfam00823 1206780003086 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1206780003087 active site 1206780003088 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1206780003089 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780003090 substrate binding site [chemical binding]; other site 1206780003091 oxyanion hole (OAH) forming residues; other site 1206780003092 enoyl-CoA hydratase; Provisional; Region: PRK06494 1206780003093 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1206780003094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1206780003095 CAAX protease self-immunity; Region: Abi; pfam02517 1206780003096 enoyl-CoA hydratase; Provisional; Region: PRK06688 1206780003097 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1206780003098 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780003099 trimer interface [polypeptide binding]; other site 1206780003100 enoyl-CoA hydratase; Provisional; Region: PRK06688 1206780003101 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780003102 substrate binding site [chemical binding]; other site 1206780003103 oxyanion hole (OAH) forming residues; other site 1206780003104 trimer interface [polypeptide binding]; other site 1206780003105 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1206780003106 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1206780003107 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1206780003108 NAD binding site [chemical binding]; other site 1206780003109 homodimer interface [polypeptide binding]; other site 1206780003110 homotetramer interface [polypeptide binding]; other site 1206780003111 active site 1206780003112 MMPL family; Region: MMPL; pfam03176 1206780003113 MMPL family; Region: MMPL; pfam03176 1206780003114 DDE superfamily endonuclease; Region: DDE_5; cl17874 1206780003115 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780003116 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780003117 active site 1206780003118 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1206780003119 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1206780003120 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1206780003121 NAD-dependent deacetylase; Provisional; Region: PRK00481 1206780003122 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1206780003123 NAD+ binding site [chemical binding]; other site 1206780003124 substrate binding site [chemical binding]; other site 1206780003125 Zn binding site [ion binding]; other site 1206780003126 Predicted transcriptional regulators [Transcription]; Region: COG1725 1206780003127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206780003128 DNA-binding site [nucleotide binding]; DNA binding site 1206780003129 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1206780003130 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1206780003131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1206780003132 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1206780003133 uncharacterized HhH-GPD family protein; Region: TIGR03252 1206780003134 minor groove reading motif; other site 1206780003135 helix-hairpin-helix signature motif; other site 1206780003136 mannosyltransferase; Provisional; Region: pimE; PRK13375 1206780003137 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1206780003138 aromatic arch; other site 1206780003139 DCoH dimer interaction site [polypeptide binding]; other site 1206780003140 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1206780003141 DCoH tetramer interaction site [polypeptide binding]; other site 1206780003142 substrate binding site [chemical binding]; other site 1206780003143 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1206780003144 active site 1206780003145 8-oxo-dGMP binding site [chemical binding]; other site 1206780003146 nudix motif; other site 1206780003147 metal binding site [ion binding]; metal-binding site 1206780003148 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1206780003149 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1206780003150 [4Fe-4S] binding site [ion binding]; other site 1206780003151 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1206780003152 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1206780003153 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1206780003154 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1206780003155 molybdopterin cofactor binding site; other site 1206780003156 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1206780003157 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1206780003158 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1206780003159 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1206780003160 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1206780003161 G1 box; other site 1206780003162 putative GEF interaction site [polypeptide binding]; other site 1206780003163 GTP/Mg2+ binding site [chemical binding]; other site 1206780003164 Switch I region; other site 1206780003165 G2 box; other site 1206780003166 G3 box; other site 1206780003167 Switch II region; other site 1206780003168 G4 box; other site 1206780003169 G5 box; other site 1206780003170 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1206780003171 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1206780003172 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1206780003173 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1206780003174 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1206780003175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780003176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780003177 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780003178 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780003179 PPE family; Region: PPE; pfam00823 1206780003180 PE family; Region: PE; pfam00934 1206780003181 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1206780003182 PE family; Region: PE; pfam00934 1206780003183 FO synthase; Reviewed; Region: fbiC; PRK09234 1206780003184 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206780003185 FeS/SAM binding site; other site 1206780003186 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206780003187 FeS/SAM binding site; other site 1206780003188 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1206780003189 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1206780003190 active site 1206780003191 FMN binding site [chemical binding]; other site 1206780003192 2,4-decadienoyl-CoA binding site; other site 1206780003193 catalytic residue [active] 1206780003194 4Fe-4S cluster binding site [ion binding]; other site 1206780003195 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1206780003196 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206780003197 Predicted transcriptional regulators [Transcription]; Region: COG1695 1206780003198 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1206780003199 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1206780003200 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1206780003201 4Fe-4S binding domain; Region: Fer4; pfam00037 1206780003202 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1206780003203 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206780003204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780003205 homodimer interface [polypeptide binding]; other site 1206780003206 catalytic residue [active] 1206780003207 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1206780003208 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1206780003209 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1206780003210 ATP binding site [chemical binding]; other site 1206780003211 putative Mg++ binding site [ion binding]; other site 1206780003212 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1206780003213 ATP-binding site [chemical binding]; other site 1206780003214 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1206780003215 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780003216 active site 1206780003217 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1206780003218 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1206780003219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780003220 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1206780003221 Enoylreductase; Region: PKS_ER; smart00829 1206780003222 NAD(P) binding site [chemical binding]; other site 1206780003223 KR domain; Region: KR; pfam08659 1206780003224 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1206780003225 putative NADP binding site [chemical binding]; other site 1206780003226 active site 1206780003227 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780003228 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1206780003229 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1206780003230 PE-PPE domain; Region: PE-PPE; pfam08237 1206780003231 acyl-CoA synthetase; Validated; Region: PRK05850 1206780003232 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1206780003233 acyl-activating enzyme (AAE) consensus motif; other site 1206780003234 active site 1206780003235 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1206780003236 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1206780003237 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1206780003238 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1206780003239 Glutamate binding site [chemical binding]; other site 1206780003240 NAD binding site [chemical binding]; other site 1206780003241 catalytic residues [active] 1206780003242 Proline dehydrogenase; Region: Pro_dh; pfam01619 1206780003243 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1206780003244 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206780003245 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206780003246 DNA binding residues [nucleotide binding] 1206780003247 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1206780003248 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1206780003249 PGAP1-like protein; Region: PGAP1; pfam07819 1206780003250 acyl-CoA synthetase; Validated; Region: PRK07787 1206780003251 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780003252 acyl-activating enzyme (AAE) consensus motif; other site 1206780003253 AMP binding site [chemical binding]; other site 1206780003254 active site 1206780003255 CoA binding site [chemical binding]; other site 1206780003256 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1206780003257 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1206780003258 PE family; Region: PE; pfam00934 1206780003259 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780003260 PPE family; Region: PPE; pfam00823 1206780003261 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780003262 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1206780003263 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1206780003264 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1206780003265 MULE transposase domain; Region: MULE; pfam10551 1206780003266 metabolite-proton symporter; Region: 2A0106; TIGR00883 1206780003267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780003268 putative substrate translocation pore; other site 1206780003269 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1206780003270 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1206780003271 putative trimer interface [polypeptide binding]; other site 1206780003272 putative CoA binding site [chemical binding]; other site 1206780003273 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1206780003274 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1206780003275 metal binding site [ion binding]; metal-binding site 1206780003276 putative dimer interface [polypeptide binding]; other site 1206780003277 TIGR00730 family protein; Region: TIGR00730 1206780003278 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1206780003279 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1206780003280 acyl-activating enzyme (AAE) consensus motif; other site 1206780003281 putative AMP binding site [chemical binding]; other site 1206780003282 putative active site [active] 1206780003283 putative CoA binding site [chemical binding]; other site 1206780003284 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1206780003285 dihydropteroate synthase; Region: DHPS; TIGR01496 1206780003286 substrate binding pocket [chemical binding]; other site 1206780003287 dimer interface [polypeptide binding]; other site 1206780003288 inhibitor binding site; inhibition site 1206780003289 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1206780003290 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1206780003291 DivIVA domain; Region: DivI1A_domain; TIGR03544 1206780003292 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 1206780003293 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1206780003294 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1206780003295 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1206780003296 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1206780003297 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1206780003298 ligand binding site; other site 1206780003299 oligomer interface; other site 1206780003300 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1206780003301 dimer interface [polypeptide binding]; other site 1206780003302 N-terminal domain interface [polypeptide binding]; other site 1206780003303 sulfate 1 binding site; other site 1206780003304 PE family; Region: PE; pfam00934 1206780003305 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1206780003306 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1206780003307 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1206780003308 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1206780003309 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1206780003310 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1206780003311 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1206780003312 Walker A/P-loop; other site 1206780003313 ATP binding site [chemical binding]; other site 1206780003314 Q-loop/lid; other site 1206780003315 ABC transporter signature motif; other site 1206780003316 Walker B; other site 1206780003317 D-loop; other site 1206780003318 H-loop/switch region; other site 1206780003319 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1206780003320 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780003321 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1206780003322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780003323 S-adenosylmethionine binding site [chemical binding]; other site 1206780003324 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1206780003325 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206780003326 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206780003327 DNA binding residues [nucleotide binding] 1206780003328 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1206780003329 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1206780003330 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1206780003331 protein binding site [polypeptide binding]; other site 1206780003332 sec-independent translocase; Provisional; Region: PRK03100 1206780003333 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1206780003334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206780003335 active site 1206780003336 motif I; other site 1206780003337 motif II; other site 1206780003338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206780003339 Predicted membrane protein [Function unknown]; Region: COG3428 1206780003340 Bacterial PH domain; Region: DUF304; pfam03703 1206780003341 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1206780003342 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1206780003343 Domain of unknown function DUF59; Region: DUF59; cl00941 1206780003344 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1206780003345 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1206780003346 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1206780003347 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1206780003348 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1206780003349 catalytic residue [active] 1206780003350 Predicted membrane protein [Function unknown]; Region: COG4420 1206780003351 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1206780003352 MgtE intracellular N domain; Region: MgtE_N; smart00924 1206780003353 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1206780003354 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1206780003355 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1206780003356 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1206780003357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780003358 dimer interface [polypeptide binding]; other site 1206780003359 conserved gate region; other site 1206780003360 putative PBP binding loops; other site 1206780003361 ABC-ATPase subunit interface; other site 1206780003362 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1206780003363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780003364 dimer interface [polypeptide binding]; other site 1206780003365 conserved gate region; other site 1206780003366 ABC-ATPase subunit interface; other site 1206780003367 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1206780003368 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1206780003369 Walker A/P-loop; other site 1206780003370 ATP binding site [chemical binding]; other site 1206780003371 Q-loop/lid; other site 1206780003372 ABC transporter signature motif; other site 1206780003373 Walker B; other site 1206780003374 D-loop; other site 1206780003375 H-loop/switch region; other site 1206780003376 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1206780003377 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1206780003378 oligomer interface [polypeptide binding]; other site 1206780003379 metal binding site [ion binding]; metal-binding site 1206780003380 metal binding site [ion binding]; metal-binding site 1206780003381 putative Cl binding site [ion binding]; other site 1206780003382 basic sphincter; other site 1206780003383 hydrophobic gate; other site 1206780003384 periplasmic entrance; other site 1206780003385 malate dehydrogenase; Provisional; Region: PRK05442 1206780003386 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1206780003387 NAD(P) binding site [chemical binding]; other site 1206780003388 dimer interface [polypeptide binding]; other site 1206780003389 malate binding site [chemical binding]; other site 1206780003390 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1206780003391 PE family; Region: PE; pfam00934 1206780003392 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1206780003393 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1206780003394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780003395 NAD(P) binding site [chemical binding]; other site 1206780003396 active site 1206780003397 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1206780003398 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1206780003399 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1206780003400 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1206780003401 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1206780003402 TPP-binding site [chemical binding]; other site 1206780003403 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1206780003404 dimer interface [polypeptide binding]; other site 1206780003405 PYR/PP interface [polypeptide binding]; other site 1206780003406 TPP binding site [chemical binding]; other site 1206780003407 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1206780003408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780003409 putative substrate translocation pore; other site 1206780003410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780003411 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1206780003412 RNase_H superfamily; Region: RNase_H_2; pfam13482 1206780003413 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1206780003414 Part of AAA domain; Region: AAA_19; pfam13245 1206780003415 AAA domain; Region: AAA_12; pfam13087 1206780003416 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1206780003417 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1206780003418 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1206780003419 ATP binding site [chemical binding]; other site 1206780003420 Mg++ binding site [ion binding]; other site 1206780003421 motif III; other site 1206780003422 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206780003423 nucleotide binding region [chemical binding]; other site 1206780003424 ATP-binding site [chemical binding]; other site 1206780003425 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1206780003426 putative RNA binding site [nucleotide binding]; other site 1206780003427 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1206780003428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780003429 H+ Antiporter protein; Region: 2A0121; TIGR00900 1206780003430 putative substrate translocation pore; other site 1206780003431 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1206780003432 Fe-S cluster binding site [ion binding]; other site 1206780003433 DNA binding site [nucleotide binding] 1206780003434 active site 1206780003435 hypothetical protein; Provisional; Region: PRK07236 1206780003436 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1206780003437 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1206780003438 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1206780003439 HIT family signature motif; other site 1206780003440 catalytic residue [active] 1206780003441 amidase; Provisional; Region: PRK12470 1206780003442 Amidase; Region: Amidase; pfam01425 1206780003443 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1206780003444 cyclase homology domain; Region: CHD; cd07302 1206780003445 nucleotidyl binding site; other site 1206780003446 metal binding site [ion binding]; metal-binding site 1206780003447 dimer interface [polypeptide binding]; other site 1206780003448 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1206780003449 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1206780003450 active site 1206780003451 ATP binding site [chemical binding]; other site 1206780003452 substrate binding site [chemical binding]; other site 1206780003453 activation loop (A-loop); other site 1206780003454 PknH-like extracellular domain; Region: PknH_C; pfam14032 1206780003455 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1206780003456 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1206780003457 DNA binding site [nucleotide binding] 1206780003458 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1206780003459 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1206780003460 phosphopeptide binding site; other site 1206780003461 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1206780003462 putative active site [active] 1206780003463 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1206780003464 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1206780003465 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1206780003466 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206780003467 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1206780003468 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1206780003469 Walker A/P-loop; other site 1206780003470 ATP binding site [chemical binding]; other site 1206780003471 Q-loop/lid; other site 1206780003472 ABC transporter signature motif; other site 1206780003473 Walker B; other site 1206780003474 D-loop; other site 1206780003475 H-loop/switch region; other site 1206780003476 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1206780003477 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1206780003478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206780003479 Walker A/P-loop; other site 1206780003480 ATP binding site [chemical binding]; other site 1206780003481 Q-loop/lid; other site 1206780003482 ABC transporter signature motif; other site 1206780003483 Walker B; other site 1206780003484 D-loop; other site 1206780003485 H-loop/switch region; other site 1206780003486 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1206780003487 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1206780003488 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206780003489 catalytic core [active] 1206780003490 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1206780003491 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1206780003492 active site 1206780003493 metal binding site [ion binding]; metal-binding site 1206780003494 DNA binding site [nucleotide binding] 1206780003495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206780003496 Walker A/P-loop; other site 1206780003497 ATP binding site [chemical binding]; other site 1206780003498 choline dehydrogenase; Validated; Region: PRK02106 1206780003499 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206780003500 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1206780003501 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1206780003502 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1206780003503 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1206780003504 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1206780003505 Walker A/P-loop; other site 1206780003506 ATP binding site [chemical binding]; other site 1206780003507 Q-loop/lid; other site 1206780003508 ABC transporter signature motif; other site 1206780003509 Walker B; other site 1206780003510 D-loop; other site 1206780003511 H-loop/switch region; other site 1206780003512 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1206780003513 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1206780003514 Walker A/P-loop; other site 1206780003515 ATP binding site [chemical binding]; other site 1206780003516 Q-loop/lid; other site 1206780003517 ABC transporter signature motif; other site 1206780003518 Walker B; other site 1206780003519 D-loop; other site 1206780003520 H-loop/switch region; other site 1206780003521 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1206780003522 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1206780003523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780003524 dimer interface [polypeptide binding]; other site 1206780003525 conserved gate region; other site 1206780003526 putative PBP binding loops; other site 1206780003527 ABC-ATPase subunit interface; other site 1206780003528 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1206780003529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780003530 dimer interface [polypeptide binding]; other site 1206780003531 conserved gate region; other site 1206780003532 putative PBP binding loops; other site 1206780003533 ABC-ATPase subunit interface; other site 1206780003534 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1206780003535 active site clefts [active] 1206780003536 zinc binding site [ion binding]; other site 1206780003537 dimer interface [polypeptide binding]; other site 1206780003538 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1206780003539 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1206780003540 Active Sites [active] 1206780003541 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1206780003542 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1206780003543 CysD dimerization site [polypeptide binding]; other site 1206780003544 G1 box; other site 1206780003545 putative GEF interaction site [polypeptide binding]; other site 1206780003546 GTP/Mg2+ binding site [chemical binding]; other site 1206780003547 Switch I region; other site 1206780003548 G2 box; other site 1206780003549 G3 box; other site 1206780003550 Switch II region; other site 1206780003551 G4 box; other site 1206780003552 G5 box; other site 1206780003553 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1206780003554 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1206780003555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206780003556 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1206780003557 Walker A/P-loop; other site 1206780003558 ligand-binding site [chemical binding]; other site 1206780003559 ATP binding site [chemical binding]; other site 1206780003560 Rrf2 family protein; Region: rrf2_super; TIGR00738 1206780003561 Transcriptional regulator; Region: Rrf2; pfam02082 1206780003562 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206780003563 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1206780003564 Putative esterase; Region: Esterase; pfam00756 1206780003565 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1206780003566 Predicted membrane protein [Function unknown]; Region: COG4325 1206780003567 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1206780003568 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1206780003569 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1206780003570 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1206780003571 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1206780003572 active site 1206780003573 HIGH motif; other site 1206780003574 KMSK motif region; other site 1206780003575 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1206780003576 tRNA binding surface [nucleotide binding]; other site 1206780003577 anticodon binding site; other site 1206780003578 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1206780003579 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1206780003580 active site 1206780003581 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1206780003582 substrate binding site [chemical binding]; other site 1206780003583 catalytic residues [active] 1206780003584 dimer interface [polypeptide binding]; other site 1206780003585 homoserine dehydrogenase; Provisional; Region: PRK06349 1206780003586 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1206780003587 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1206780003588 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1206780003589 threonine synthase; Reviewed; Region: PRK06721 1206780003590 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1206780003591 homodimer interface [polypeptide binding]; other site 1206780003592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780003593 catalytic residue [active] 1206780003594 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1206780003595 transcription termination factor Rho; Provisional; Region: PRK12678 1206780003596 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1206780003597 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1206780003598 RNA binding site [nucleotide binding]; other site 1206780003599 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1206780003600 multimer interface [polypeptide binding]; other site 1206780003601 Walker A motif; other site 1206780003602 ATP binding site [chemical binding]; other site 1206780003603 Walker B motif; other site 1206780003604 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1206780003605 peptide chain release factor 1; Region: prfA; TIGR00019 1206780003606 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1206780003607 RF-1 domain; Region: RF-1; pfam00472 1206780003608 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1206780003609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780003610 S-adenosylmethionine binding site [chemical binding]; other site 1206780003611 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1206780003612 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1206780003613 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1206780003614 Mg++ binding site [ion binding]; other site 1206780003615 putative catalytic motif [active] 1206780003616 substrate binding site [chemical binding]; other site 1206780003617 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1206780003618 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1206780003619 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1206780003620 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1206780003621 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1206780003622 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1206780003623 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1206780003624 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1206780003625 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1206780003626 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1206780003627 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1206780003628 Walker A motif; other site 1206780003629 ATP binding site [chemical binding]; other site 1206780003630 Walker B motif; other site 1206780003631 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1206780003632 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1206780003633 core domain interface [polypeptide binding]; other site 1206780003634 delta subunit interface [polypeptide binding]; other site 1206780003635 epsilon subunit interface [polypeptide binding]; other site 1206780003636 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1206780003637 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1206780003638 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1206780003639 alpha subunit interaction interface [polypeptide binding]; other site 1206780003640 Walker A motif; other site 1206780003641 ATP binding site [chemical binding]; other site 1206780003642 Walker B motif; other site 1206780003643 inhibitor binding site; inhibition site 1206780003644 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1206780003645 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1206780003646 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1206780003647 gamma subunit interface [polypeptide binding]; other site 1206780003648 epsilon subunit interface [polypeptide binding]; other site 1206780003649 LBP interface [polypeptide binding]; other site 1206780003650 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1206780003651 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1206780003652 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1206780003653 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1206780003654 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1206780003655 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1206780003656 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1206780003657 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1206780003658 hinge; other site 1206780003659 active site 1206780003660 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1206780003661 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1206780003662 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1206780003663 DNA binding site [nucleotide binding] 1206780003664 active site 1206780003665 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1206780003666 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1206780003667 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1206780003668 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1206780003669 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1206780003670 minor groove reading motif; other site 1206780003671 helix-hairpin-helix signature motif; other site 1206780003672 substrate binding pocket [chemical binding]; other site 1206780003673 active site 1206780003674 HAMP domain; Region: HAMP; pfam00672 1206780003675 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1206780003676 cyclase homology domain; Region: CHD; cd07302 1206780003677 nucleotidyl binding site; other site 1206780003678 metal binding site [ion binding]; metal-binding site 1206780003679 dimer interface [polypeptide binding]; other site 1206780003680 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1206780003681 dimerization interface [polypeptide binding]; other site 1206780003682 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1206780003683 cyclase homology domain; Region: CHD; cd07302 1206780003684 nucleotidyl binding site; other site 1206780003685 metal binding site [ion binding]; metal-binding site 1206780003686 dimer interface [polypeptide binding]; other site 1206780003687 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1206780003688 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1206780003689 dimerization interface [polypeptide binding]; other site 1206780003690 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1206780003691 cyclase homology domain; Region: CHD; cd07302 1206780003692 nucleotidyl binding site; other site 1206780003693 metal binding site [ion binding]; metal-binding site 1206780003694 dimer interface [polypeptide binding]; other site 1206780003695 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1206780003696 hypothetical protein; Provisional; Region: PRK03298 1206780003697 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206780003698 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1206780003699 dimer interface [polypeptide binding]; other site 1206780003700 substrate binding site [chemical binding]; other site 1206780003701 metal binding site [ion binding]; metal-binding site 1206780003702 putative acyltransferase; Provisional; Region: PRK05790 1206780003703 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1206780003704 dimer interface [polypeptide binding]; other site 1206780003705 active site 1206780003706 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1206780003707 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1206780003708 PE family; Region: PE; pfam00934 1206780003709 glycogen branching enzyme; Provisional; Region: PRK05402 1206780003710 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1206780003711 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1206780003712 active site 1206780003713 catalytic site [active] 1206780003714 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1206780003715 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1206780003716 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1206780003717 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1206780003718 active site 1206780003719 homodimer interface [polypeptide binding]; other site 1206780003720 catalytic site [active] 1206780003721 acceptor binding site [chemical binding]; other site 1206780003722 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1206780003723 putative homodimer interface [polypeptide binding]; other site 1206780003724 putative active site pocket [active] 1206780003725 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1206780003726 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1206780003727 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1206780003728 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1206780003729 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1206780003730 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1206780003731 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1206780003732 active site 1206780003733 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1206780003734 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1206780003735 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1206780003736 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1206780003737 putative active site pocket [active] 1206780003738 cleavage site 1206780003739 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1206780003740 MPN+ (JAMM) motif; other site 1206780003741 Zinc-binding site [ion binding]; other site 1206780003742 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1206780003743 MoaE interaction surface [polypeptide binding]; other site 1206780003744 MoeB interaction surface [polypeptide binding]; other site 1206780003745 thiocarboxylated glycine; other site 1206780003746 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1206780003747 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1206780003748 dimer interface [polypeptide binding]; other site 1206780003749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780003750 catalytic residue [active] 1206780003751 Rhomboid family; Region: Rhomboid; pfam01694 1206780003752 glutamate racemase; Provisional; Region: PRK00865 1206780003753 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1206780003754 ribonuclease PH; Reviewed; Region: rph; PRK00173 1206780003755 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1206780003756 hexamer interface [polypeptide binding]; other site 1206780003757 active site 1206780003758 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1206780003759 active site 1206780003760 dimerization interface [polypeptide binding]; other site 1206780003761 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1206780003762 Glucitol operon activator [Transcription]; Region: GutM; COG4578 1206780003763 acyl carrier protein; Validated; Region: PRK05883 1206780003764 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1206780003765 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1206780003766 acyl-activating enzyme (AAE) consensus motif; other site 1206780003767 active site 1206780003768 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780003769 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780003770 active site 1206780003771 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1206780003772 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1206780003773 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1206780003774 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1206780003775 FAD binding pocket [chemical binding]; other site 1206780003776 FAD binding motif [chemical binding]; other site 1206780003777 phosphate binding motif [ion binding]; other site 1206780003778 NAD binding pocket [chemical binding]; other site 1206780003779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206780003780 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1206780003781 Walker A/P-loop; other site 1206780003782 ATP binding site [chemical binding]; other site 1206780003783 Q-loop/lid; other site 1206780003784 ABC transporter signature motif; other site 1206780003785 Walker B; other site 1206780003786 D-loop; other site 1206780003787 H-loop/switch region; other site 1206780003788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206780003789 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206780003790 Walker A/P-loop; other site 1206780003791 ATP binding site [chemical binding]; other site 1206780003792 Q-loop/lid; other site 1206780003793 ABC transporter signature motif; other site 1206780003794 Walker B; other site 1206780003795 D-loop; other site 1206780003796 H-loop/switch region; other site 1206780003797 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1206780003798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780003799 NAD(P) binding site [chemical binding]; other site 1206780003800 active site 1206780003801 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1206780003802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780003803 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1206780003804 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1206780003805 GAF domain; Region: GAF; pfam01590 1206780003806 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1206780003807 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1206780003808 metal binding site [ion binding]; metal-binding site 1206780003809 active site 1206780003810 I-site; other site 1206780003811 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1206780003812 hypothetical protein; Provisional; Region: PRK07877 1206780003813 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1206780003814 ATP binding site [chemical binding]; other site 1206780003815 substrate interface [chemical binding]; other site 1206780003816 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1206780003817 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1206780003818 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1206780003819 cyclase homology domain; Region: CHD; cd07302 1206780003820 nucleotidyl binding site; other site 1206780003821 dimer interface [polypeptide binding]; other site 1206780003822 metal binding site [ion binding]; metal-binding site 1206780003823 AAA ATPase domain; Region: AAA_16; pfam13191 1206780003824 Predicted ATPase [General function prediction only]; Region: COG3903 1206780003825 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1206780003826 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1206780003827 DNA binding residues [nucleotide binding] 1206780003828 dimerization interface [polypeptide binding]; other site 1206780003829 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1206780003830 cyclase homology domain; Region: CHD; cd07302 1206780003831 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1206780003832 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1206780003833 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780003834 PPE family; Region: PPE; pfam00823 1206780003835 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780003836 PAS fold; Region: PAS_4; pfam08448 1206780003837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1206780003838 putative active site [active] 1206780003839 heme pocket [chemical binding]; other site 1206780003840 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1206780003841 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1206780003842 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1206780003843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1206780003844 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1206780003845 anti sigma factor interaction site; other site 1206780003846 regulatory phosphorylation site [posttranslational modification]; other site 1206780003847 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1206780003848 anti sigma factor interaction site; other site 1206780003849 regulatory phosphorylation site [posttranslational modification]; other site 1206780003850 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1206780003851 synthetase active site [active] 1206780003852 NTP binding site [chemical binding]; other site 1206780003853 metal binding site [ion binding]; metal-binding site 1206780003854 Beta-lactamase; Region: Beta-lactamase; pfam00144 1206780003855 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1206780003856 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1206780003857 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 1206780003858 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1206780003859 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1206780003860 putative di-iron ligands [ion binding]; other site 1206780003861 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1206780003862 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1206780003863 malonyl-CoA binding site [chemical binding]; other site 1206780003864 dimer interface [polypeptide binding]; other site 1206780003865 active site 1206780003866 product binding site; other site 1206780003867 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1206780003868 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1206780003869 uncharacterized domain; Region: TIGR00702 1206780003870 YcaO-like family; Region: YcaO; pfam02624 1206780003871 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1206780003872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780003873 S-adenosylmethionine binding site [chemical binding]; other site 1206780003874 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780003875 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780003876 active site 1206780003877 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1206780003878 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1206780003879 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1206780003880 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1206780003881 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1206780003882 dihydroorotase; Validated; Region: pyrC; PRK09357 1206780003883 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1206780003884 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1206780003885 active site 1206780003886 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1206780003887 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1206780003888 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1206780003889 catalytic site [active] 1206780003890 subunit interface [polypeptide binding]; other site 1206780003891 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1206780003892 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1206780003893 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1206780003894 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1206780003895 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1206780003896 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1206780003897 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1206780003898 IMP binding site; other site 1206780003899 dimer interface [polypeptide binding]; other site 1206780003900 interdomain contacts; other site 1206780003901 partial ornithine binding site; other site 1206780003902 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1206780003903 active site 1206780003904 dimer interface [polypeptide binding]; other site 1206780003905 PE family; Region: PE; pfam00934 1206780003906 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780003907 PPE family; Region: PPE; pfam00823 1206780003908 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1206780003909 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1206780003910 catalytic site [active] 1206780003911 G-X2-G-X-G-K; other site 1206780003912 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1206780003913 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1206780003914 Flavoprotein; Region: Flavoprotein; pfam02441 1206780003915 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1206780003916 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1206780003917 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1206780003918 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1206780003919 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1206780003920 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1206780003921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1206780003922 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780003923 Cytochrome P450; Region: p450; cl12078 1206780003924 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1206780003925 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1206780003926 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206780003927 PE family; Region: PE; pfam00934 1206780003928 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1206780003929 oligomeric interface; other site 1206780003930 putative active site [active] 1206780003931 homodimer interface [polypeptide binding]; other site 1206780003932 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1206780003933 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1206780003934 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1206780003935 substrate binding pocket [chemical binding]; other site 1206780003936 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1206780003937 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1206780003938 substrate binding pocket [chemical binding]; other site 1206780003939 Predicted membrane protein [Function unknown]; Region: COG3714 1206780003940 primosome assembly protein PriA; Provisional; Region: PRK14873 1206780003941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780003942 S-adenosylmethionine binding site [chemical binding]; other site 1206780003943 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1206780003944 MarR family; Region: MarR; pfam01047 1206780003945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780003946 S-adenosylmethionine binding site [chemical binding]; other site 1206780003947 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1206780003948 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1206780003949 putative active site [active] 1206780003950 substrate binding site [chemical binding]; other site 1206780003951 putative cosubstrate binding site; other site 1206780003952 catalytic site [active] 1206780003953 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1206780003954 substrate binding site [chemical binding]; other site 1206780003955 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1206780003956 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1206780003957 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1206780003958 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1206780003959 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1206780003960 substrate binding site [chemical binding]; other site 1206780003961 hexamer interface [polypeptide binding]; other site 1206780003962 metal binding site [ion binding]; metal-binding site 1206780003963 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1206780003964 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1206780003965 catalytic motif [active] 1206780003966 Zn binding site [ion binding]; other site 1206780003967 RibD C-terminal domain; Region: RibD_C; pfam01872 1206780003968 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1206780003969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780003970 putative substrate translocation pore; other site 1206780003971 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1206780003972 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1206780003973 Lumazine binding domain; Region: Lum_binding; pfam00677 1206780003974 Lumazine binding domain; Region: Lum_binding; pfam00677 1206780003975 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1206780003976 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1206780003977 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1206780003978 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1206780003979 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1206780003980 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1206780003981 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1206780003982 dimerization interface [polypeptide binding]; other site 1206780003983 active site 1206780003984 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1206780003985 homopentamer interface [polypeptide binding]; other site 1206780003986 active site 1206780003987 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1206780003988 PknH-like extracellular domain; Region: PknH_C; pfam14032 1206780003989 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1206780003990 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1206780003991 putative sugar binding sites [chemical binding]; other site 1206780003992 Q-X-W motif; other site 1206780003993 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1206780003994 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1206780003995 GIY-YIG motif/motif A; other site 1206780003996 active site 1206780003997 catalytic site [active] 1206780003998 putative DNA binding site [nucleotide binding]; other site 1206780003999 metal binding site [ion binding]; metal-binding site 1206780004000 UvrB/uvrC motif; Region: UVR; pfam02151 1206780004001 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1206780004002 Helix-hairpin-helix motif; Region: HHH; pfam00633 1206780004003 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1206780004004 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1206780004005 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1206780004006 phosphate binding site [ion binding]; other site 1206780004007 putative substrate binding pocket [chemical binding]; other site 1206780004008 dimer interface [polypeptide binding]; other site 1206780004009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1206780004010 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1206780004011 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1206780004012 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1206780004013 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1206780004014 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1206780004015 acyl-CoA synthetase; Provisional; Region: PRK13382 1206780004016 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1206780004017 acyl-activating enzyme (AAE) consensus motif; other site 1206780004018 putative AMP binding site [chemical binding]; other site 1206780004019 putative active site [active] 1206780004020 putative CoA binding site [chemical binding]; other site 1206780004021 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1206780004022 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1206780004023 putative acyl-acceptor binding pocket; other site 1206780004024 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1206780004025 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1206780004026 PE family; Region: PE; pfam00934 1206780004027 PE-PPE domain; Region: PE-PPE; pfam08237 1206780004028 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1206780004029 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1206780004030 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1206780004031 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1206780004032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1206780004033 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1206780004034 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1206780004035 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1206780004036 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1206780004037 Phosphoglycerate kinase; Region: PGK; pfam00162 1206780004038 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1206780004039 substrate binding site [chemical binding]; other site 1206780004040 hinge regions; other site 1206780004041 ADP binding site [chemical binding]; other site 1206780004042 catalytic site [active] 1206780004043 triosephosphate isomerase; Provisional; Region: PRK14567 1206780004044 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1206780004045 substrate binding site [chemical binding]; other site 1206780004046 dimer interface [polypeptide binding]; other site 1206780004047 catalytic triad [active] 1206780004048 SnoaL-like domain; Region: SnoaL_2; pfam12680 1206780004049 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1206780004050 PE family; Region: PE; pfam00934 1206780004051 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1206780004052 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1206780004053 molybdopterin cofactor binding site [chemical binding]; other site 1206780004054 substrate binding site [chemical binding]; other site 1206780004055 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1206780004056 molybdopterin cofactor binding site; other site 1206780004057 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1206780004058 hydrophobic ligand binding site; other site 1206780004059 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1206780004060 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1206780004061 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1206780004062 putative active site [active] 1206780004063 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1206780004064 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 1206780004065 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1206780004066 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1206780004067 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1206780004068 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1206780004069 putative active site [active] 1206780004070 transaldolase; Provisional; Region: PRK03903 1206780004071 catalytic residue [active] 1206780004072 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1206780004073 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1206780004074 TPP-binding site [chemical binding]; other site 1206780004075 dimer interface [polypeptide binding]; other site 1206780004076 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1206780004077 PYR/PP interface [polypeptide binding]; other site 1206780004078 dimer interface [polypeptide binding]; other site 1206780004079 TPP binding site [chemical binding]; other site 1206780004080 PE family; Region: PE; pfam00934 1206780004081 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1206780004082 UbiA prenyltransferase family; Region: UbiA; pfam01040 1206780004083 PE family; Region: PE; pfam00934 1206780004084 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1206780004085 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1206780004086 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1206780004087 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1206780004088 NADP binding site [chemical binding]; other site 1206780004089 dimer interface [polypeptide binding]; other site 1206780004090 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1206780004091 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1206780004092 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1206780004093 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1206780004094 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1206780004095 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1206780004096 Walker A/P-loop; other site 1206780004097 ATP binding site [chemical binding]; other site 1206780004098 Q-loop/lid; other site 1206780004099 ABC transporter signature motif; other site 1206780004100 Walker B; other site 1206780004101 D-loop; other site 1206780004102 H-loop/switch region; other site 1206780004103 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1206780004104 Predicted transcriptional regulator [Transcription]; Region: COG2345 1206780004105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206780004106 putative DNA binding site [nucleotide binding]; other site 1206780004107 putative Zn2+ binding site [ion binding]; other site 1206780004108 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1206780004109 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1206780004110 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1206780004111 protein-splicing catalytic site; other site 1206780004112 thioester formation/cholesterol transfer; other site 1206780004113 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1206780004114 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1206780004115 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1206780004116 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1206780004117 FeS assembly protein SufD; Region: sufD; TIGR01981 1206780004118 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1206780004119 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1206780004120 Walker A/P-loop; other site 1206780004121 ATP binding site [chemical binding]; other site 1206780004122 Q-loop/lid; other site 1206780004123 ABC transporter signature motif; other site 1206780004124 Walker B; other site 1206780004125 D-loop; other site 1206780004126 H-loop/switch region; other site 1206780004127 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1206780004128 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1206780004129 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206780004130 catalytic residue [active] 1206780004131 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1206780004132 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1206780004133 trimerization site [polypeptide binding]; other site 1206780004134 active site 1206780004135 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1206780004136 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1206780004137 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1206780004138 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780004139 active site 1206780004140 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1206780004141 PE family; Region: PE; pfam00934 1206780004142 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1206780004143 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206780004144 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1206780004145 catalytic residues [active] 1206780004146 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1206780004147 catalytic residues [active] 1206780004148 enoyl-CoA hydratase; Provisional; Region: PRK05864 1206780004149 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780004150 substrate binding site [chemical binding]; other site 1206780004151 oxyanion hole (OAH) forming residues; other site 1206780004152 trimer interface [polypeptide binding]; other site 1206780004153 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1206780004154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206780004155 Walker A/P-loop; other site 1206780004156 ATP binding site [chemical binding]; other site 1206780004157 Q-loop/lid; other site 1206780004158 ABC transporter signature motif; other site 1206780004159 Walker B; other site 1206780004160 D-loop; other site 1206780004161 H-loop/switch region; other site 1206780004162 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206780004163 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780004164 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780004165 aconitate hydratase; Validated; Region: PRK09277 1206780004166 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1206780004167 substrate binding site [chemical binding]; other site 1206780004168 ligand binding site [chemical binding]; other site 1206780004169 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1206780004170 substrate binding site [chemical binding]; other site 1206780004171 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1206780004172 NlpC/P60 family; Region: NLPC_P60; pfam00877 1206780004173 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1206780004174 NlpC/P60 family; Region: NLPC_P60; pfam00877 1206780004175 MoxR-like ATPases [General function prediction only]; Region: COG0714 1206780004176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780004177 Walker A motif; other site 1206780004178 ATP binding site [chemical binding]; other site 1206780004179 Walker B motif; other site 1206780004180 arginine finger; other site 1206780004181 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1206780004182 Protein of unknown function DUF58; Region: DUF58; pfam01882 1206780004183 hypothetical protein; Provisional; Region: PRK13685 1206780004184 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1206780004185 metal ion-dependent adhesion site (MIDAS); other site 1206780004186 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1206780004187 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1206780004188 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1206780004189 NAD(P) binding site [chemical binding]; other site 1206780004190 homotetramer interface [polypeptide binding]; other site 1206780004191 homodimer interface [polypeptide binding]; other site 1206780004192 active site 1206780004193 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1206780004194 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1206780004195 NAD binding site [chemical binding]; other site 1206780004196 homotetramer interface [polypeptide binding]; other site 1206780004197 homodimer interface [polypeptide binding]; other site 1206780004198 substrate binding site [chemical binding]; other site 1206780004199 active site 1206780004200 ferrochelatase; Reviewed; Region: hemH; PRK00035 1206780004201 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1206780004202 C-terminal domain interface [polypeptide binding]; other site 1206780004203 active site 1206780004204 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1206780004205 active site 1206780004206 N-terminal domain interface [polypeptide binding]; other site 1206780004207 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1206780004208 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1206780004209 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1206780004210 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1206780004211 Transposase domain (DUF772); Region: DUF772; pfam05598 1206780004212 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1206780004213 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1206780004214 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1206780004215 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1206780004216 heterodimer interface [polypeptide binding]; other site 1206780004217 substrate interaction site [chemical binding]; other site 1206780004218 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 1206780004219 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1206780004220 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1206780004221 active site 1206780004222 substrate binding site [chemical binding]; other site 1206780004223 coenzyme B12 binding site [chemical binding]; other site 1206780004224 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1206780004225 B12 binding site [chemical binding]; other site 1206780004226 cobalt ligand [ion binding]; other site 1206780004227 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1206780004228 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1206780004229 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1206780004230 Walker A; other site 1206780004231 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1206780004232 Beta-lactamase; Region: Beta-lactamase; pfam00144 1206780004233 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1206780004234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780004235 S-adenosylmethionine binding site [chemical binding]; other site 1206780004236 Dodecin; Region: Dodecin; pfam07311 1206780004237 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1206780004238 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1206780004239 Ligand binding site; other site 1206780004240 Putative Catalytic site; other site 1206780004241 DXD motif; other site 1206780004242 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1206780004243 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1206780004244 active site 1206780004245 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1206780004246 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1206780004247 inhibitor-cofactor binding pocket; inhibition site 1206780004248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780004249 catalytic residue [active] 1206780004250 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1206780004251 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1206780004252 putative trimer interface [polypeptide binding]; other site 1206780004253 putative CoA binding site [chemical binding]; other site 1206780004254 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1206780004255 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1206780004256 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1206780004257 active site 1206780004258 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206780004259 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1206780004260 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206780004261 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1206780004262 active site 1206780004263 acyl-CoA synthetase; Validated; Region: PRK05850 1206780004264 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1206780004265 acyl-activating enzyme (AAE) consensus motif; other site 1206780004266 active site 1206780004267 Transport protein; Region: actII; TIGR00833 1206780004268 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206780004269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780004270 S-adenosylmethionine binding site [chemical binding]; other site 1206780004271 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1206780004272 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1206780004273 homodimer interface [polypeptide binding]; other site 1206780004274 active site 1206780004275 TDP-binding site; other site 1206780004276 acceptor substrate-binding pocket; other site 1206780004277 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1206780004278 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1206780004279 Probable Catalytic site; other site 1206780004280 metal-binding site 1206780004281 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1206780004282 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1206780004283 homodimer interface [polypeptide binding]; other site 1206780004284 active site 1206780004285 TDP-binding site; other site 1206780004286 acceptor substrate-binding pocket; other site 1206780004287 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1206780004288 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780004289 active site 1206780004290 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1206780004291 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1206780004292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780004293 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1206780004294 Enoylreductase; Region: PKS_ER; smart00829 1206780004295 NAD(P) binding site [chemical binding]; other site 1206780004296 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1206780004297 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1206780004298 putative NADP binding site [chemical binding]; other site 1206780004299 active site 1206780004300 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780004301 acyl-CoA synthetase; Validated; Region: PRK05850 1206780004302 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1206780004303 acyl-activating enzyme (AAE) consensus motif; other site 1206780004304 active site 1206780004305 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1206780004306 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1206780004307 NAD(P) binding site [chemical binding]; other site 1206780004308 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1206780004309 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1206780004310 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1206780004311 CoenzymeA binding site [chemical binding]; other site 1206780004312 subunit interaction site [polypeptide binding]; other site 1206780004313 PHB binding site; other site 1206780004314 Nitronate monooxygenase; Region: NMO; pfam03060 1206780004315 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1206780004316 FMN binding site [chemical binding]; other site 1206780004317 substrate binding site [chemical binding]; other site 1206780004318 putative catalytic residue [active] 1206780004319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780004320 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1206780004321 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1206780004322 HIGH motif; other site 1206780004323 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1206780004324 active site 1206780004325 KMSKS motif; other site 1206780004326 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1206780004327 tRNA binding surface [nucleotide binding]; other site 1206780004328 anticodon binding site; other site 1206780004329 DNA polymerase IV; Provisional; Region: PRK03348 1206780004330 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1206780004331 active site 1206780004332 DNA binding site [nucleotide binding] 1206780004333 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1206780004334 active site 1206780004335 homodimer interface [polypeptide binding]; other site 1206780004336 homotetramer interface [polypeptide binding]; other site 1206780004337 lipoprotein signal peptidase; Provisional; Region: PRK14764 1206780004338 lipoprotein signal peptidase; Provisional; Region: PRK14787 1206780004339 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1206780004340 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1206780004341 active site 1206780004342 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1206780004343 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1206780004344 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1206780004345 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1206780004346 apolar tunnel; other site 1206780004347 heme binding site [chemical binding]; other site 1206780004348 dimerization interface [polypeptide binding]; other site 1206780004349 short chain dehydrogenase; Provisional; Region: PRK05866 1206780004350 classical (c) SDRs; Region: SDR_c; cd05233 1206780004351 NAD(P) binding site [chemical binding]; other site 1206780004352 active site 1206780004353 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1206780004354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780004355 NAD(P) binding site [chemical binding]; other site 1206780004356 active site 1206780004357 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1206780004358 hydrophobic ligand binding site; other site 1206780004359 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1206780004360 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1206780004361 active site 1206780004362 PHP Thumb interface [polypeptide binding]; other site 1206780004363 metal binding site [ion binding]; metal-binding site 1206780004364 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1206780004365 generic binding surface II; other site 1206780004366 generic binding surface I; other site 1206780004367 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780004368 PPE family; Region: PPE; pfam00823 1206780004369 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780004370 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780004371 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1206780004372 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1206780004373 acyl-activating enzyme (AAE) consensus motif; other site 1206780004374 putative AMP binding site [chemical binding]; other site 1206780004375 putative active site [active] 1206780004376 putative CoA binding site [chemical binding]; other site 1206780004377 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1206780004378 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1206780004379 putative acyl-acceptor binding pocket; other site 1206780004380 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 1206780004381 L-aspartate oxidase; Provisional; Region: PRK06175 1206780004382 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1206780004383 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1206780004384 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1206780004385 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1206780004386 Iron-sulfur protein interface; other site 1206780004387 proximal quinone binding site [chemical binding]; other site 1206780004388 C-subunit interface; other site 1206780004389 distal quinone binding site; other site 1206780004390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780004391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780004392 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1206780004393 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1206780004394 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1206780004395 threonine dehydratase; Validated; Region: PRK08639 1206780004396 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1206780004397 tetramer interface [polypeptide binding]; other site 1206780004398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780004399 catalytic residue [active] 1206780004400 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1206780004401 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1206780004402 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1206780004403 putative active site [active] 1206780004404 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1206780004405 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1206780004406 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1206780004407 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1206780004408 catalytic site [active] 1206780004409 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1206780004410 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1206780004411 active site 1206780004412 catalytic site [active] 1206780004413 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1206780004414 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1206780004415 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1206780004416 active site 1206780004417 catalytic site [active] 1206780004418 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1206780004419 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1206780004420 NlpC/P60 family; Region: NLPC_P60; pfam00877 1206780004421 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1206780004422 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1206780004423 inhibitor-cofactor binding pocket; inhibition site 1206780004424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780004425 catalytic residue [active] 1206780004426 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1206780004427 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1206780004428 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206780004429 catalytic residue [active] 1206780004430 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1206780004431 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1206780004432 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780004433 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780004434 active site 1206780004435 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780004436 biotin synthase; Validated; Region: PRK06256 1206780004437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206780004438 FeS/SAM binding site; other site 1206780004439 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1206780004440 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1206780004441 Secretory lipase; Region: LIP; pfam03583 1206780004442 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1206780004443 nudix motif; other site 1206780004444 quinolinate synthetase; Provisional; Region: PRK09375 1206780004445 L-aspartate oxidase; Provisional; Region: PRK07804 1206780004446 L-aspartate oxidase; Provisional; Region: PRK06175 1206780004447 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1206780004448 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1206780004449 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1206780004450 dimerization interface [polypeptide binding]; other site 1206780004451 active site 1206780004452 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1206780004453 S-adenosylmethionine binding site [chemical binding]; other site 1206780004454 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1206780004455 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1206780004456 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1206780004457 NAD binding site [chemical binding]; other site 1206780004458 dimerization interface [polypeptide binding]; other site 1206780004459 product binding site; other site 1206780004460 substrate binding site [chemical binding]; other site 1206780004461 zinc binding site [ion binding]; other site 1206780004462 catalytic residues [active] 1206780004463 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1206780004464 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206780004465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780004466 homodimer interface [polypeptide binding]; other site 1206780004467 catalytic residue [active] 1206780004468 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1206780004469 4-fold oligomerization interface [polypeptide binding]; other site 1206780004470 putative active site pocket [active] 1206780004471 metal binding residues [ion binding]; metal-binding site 1206780004472 3-fold/trimer interface [polypeptide binding]; other site 1206780004473 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1206780004474 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1206780004475 putative active site [active] 1206780004476 oxyanion strand; other site 1206780004477 catalytic triad [active] 1206780004478 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1206780004479 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1206780004480 catalytic residues [active] 1206780004481 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1206780004482 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1206780004483 active site 1206780004484 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1206780004485 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1206780004486 substrate binding site [chemical binding]; other site 1206780004487 glutamase interaction surface [polypeptide binding]; other site 1206780004488 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1206780004489 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1206780004490 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1206780004491 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1206780004492 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1206780004493 catalytic triad [active] 1206780004494 anthranilate synthase component I; Provisional; Region: PRK13571 1206780004495 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1206780004496 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1206780004497 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1206780004498 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1206780004499 active site 1206780004500 ribulose/triose binding site [chemical binding]; other site 1206780004501 phosphate binding site [ion binding]; other site 1206780004502 substrate (anthranilate) binding pocket [chemical binding]; other site 1206780004503 product (indole) binding pocket [chemical binding]; other site 1206780004504 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1206780004505 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1206780004506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780004507 catalytic residue [active] 1206780004508 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1206780004509 substrate binding site [chemical binding]; other site 1206780004510 active site 1206780004511 catalytic residues [active] 1206780004512 heterodimer interface [polypeptide binding]; other site 1206780004513 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1206780004514 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1206780004515 TM2 domain; Region: TM2; pfam05154 1206780004516 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1206780004517 pyruvate kinase; Provisional; Region: PRK06247 1206780004518 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1206780004519 domain interfaces; other site 1206780004520 active site 1206780004521 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1206780004522 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1206780004523 active site 1206780004524 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1206780004525 catalytic triad [active] 1206780004526 dimer interface [polypeptide binding]; other site 1206780004527 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1206780004528 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1206780004529 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1206780004530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206780004531 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1206780004532 Walker A/P-loop; other site 1206780004533 Walker A/P-loop; other site 1206780004534 ATP binding site [chemical binding]; other site 1206780004535 ATP binding site [chemical binding]; other site 1206780004536 Q-loop/lid; other site 1206780004537 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1206780004538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206780004539 Walker A/P-loop; other site 1206780004540 ATP binding site [chemical binding]; other site 1206780004541 Q-loop/lid; other site 1206780004542 ABC transporter signature motif; other site 1206780004543 Walker B; other site 1206780004544 D-loop; other site 1206780004545 H-loop/switch region; other site 1206780004546 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1206780004547 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1206780004548 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1206780004549 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1206780004550 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1206780004551 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1206780004552 cyclase homology domain; Region: CHD; cd07302 1206780004553 nucleotidyl binding site; other site 1206780004554 metal binding site [ion binding]; metal-binding site 1206780004555 dimer interface [polypeptide binding]; other site 1206780004556 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1206780004557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206780004558 active site 1206780004559 phosphorylation site [posttranslational modification] 1206780004560 intermolecular recognition site; other site 1206780004561 dimerization interface [polypeptide binding]; other site 1206780004562 ANTAR domain; Region: ANTAR; pfam03861 1206780004563 lipid-transfer protein; Provisional; Region: PRK06059 1206780004564 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1206780004565 active site 1206780004566 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1206780004567 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1206780004568 DUF35 OB-fold domain; Region: DUF35; pfam01796 1206780004569 DNA polymerase I; Provisional; Region: PRK05755 1206780004570 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1206780004571 active site 1206780004572 metal binding site 1 [ion binding]; metal-binding site 1206780004573 putative 5' ssDNA interaction site; other site 1206780004574 metal binding site 3; metal-binding site 1206780004575 metal binding site 2 [ion binding]; metal-binding site 1206780004576 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1206780004577 putative DNA binding site [nucleotide binding]; other site 1206780004578 putative metal binding site [ion binding]; other site 1206780004579 3'-5' exonuclease; Region: 35EXOc; smart00474 1206780004580 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1206780004581 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1206780004582 active site 1206780004583 DNA binding site [nucleotide binding] 1206780004584 catalytic site [active] 1206780004585 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1206780004586 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1206780004587 RNA binding site [nucleotide binding]; other site 1206780004588 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1206780004589 RNA binding site [nucleotide binding]; other site 1206780004590 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1206780004591 RNA binding site [nucleotide binding]; other site 1206780004592 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1206780004593 RNA binding site [nucleotide binding]; other site 1206780004594 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1206780004595 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1206780004596 CoA-binding site [chemical binding]; other site 1206780004597 ATP-binding [chemical binding]; other site 1206780004598 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 1206780004599 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1206780004600 excinuclease ABC subunit B; Provisional; Region: PRK05298 1206780004601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206780004602 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206780004603 nucleotide binding region [chemical binding]; other site 1206780004604 ATP-binding site [chemical binding]; other site 1206780004605 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1206780004606 UvrB/uvrC motif; Region: UVR; pfam02151 1206780004607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780004608 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1206780004609 putative substrate translocation pore; other site 1206780004610 Predicted membrane protein [Function unknown]; Region: COG5305 1206780004611 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206780004612 Ligand Binding Site [chemical binding]; other site 1206780004613 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1206780004614 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1206780004615 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1206780004616 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1206780004617 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1206780004618 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1206780004619 Predicted esterase [General function prediction only]; Region: COG0627 1206780004620 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1206780004621 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1206780004622 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1206780004623 dimer interface [polypeptide binding]; other site 1206780004624 putative anticodon binding site; other site 1206780004625 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1206780004626 motif 1; other site 1206780004627 dimer interface [polypeptide binding]; other site 1206780004628 active site 1206780004629 motif 2; other site 1206780004630 motif 3; other site 1206780004631 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1206780004632 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1206780004633 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1206780004634 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1206780004635 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1206780004636 23S rRNA binding site [nucleotide binding]; other site 1206780004637 L21 binding site [polypeptide binding]; other site 1206780004638 L13 binding site [polypeptide binding]; other site 1206780004639 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1206780004640 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1206780004641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1206780004642 PE family; Region: PE; pfam00934 1206780004643 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1206780004644 cyclase homology domain; Region: CHD; cd07302 1206780004645 nucleotidyl binding site; other site 1206780004646 metal binding site [ion binding]; metal-binding site 1206780004647 dimer interface [polypeptide binding]; other site 1206780004648 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1206780004649 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1206780004650 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1206780004651 dimer interface [polypeptide binding]; other site 1206780004652 motif 1; other site 1206780004653 active site 1206780004654 motif 2; other site 1206780004655 motif 3; other site 1206780004656 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1206780004657 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1206780004658 putative tRNA-binding site [nucleotide binding]; other site 1206780004659 B3/4 domain; Region: B3_4; pfam03483 1206780004660 tRNA synthetase B5 domain; Region: B5; smart00874 1206780004661 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1206780004662 dimer interface [polypeptide binding]; other site 1206780004663 motif 1; other site 1206780004664 motif 3; other site 1206780004665 motif 2; other site 1206780004666 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1206780004667 PE family; Region: PE; pfam00934 1206780004668 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1206780004669 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1206780004670 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1206780004671 heterotetramer interface [polypeptide binding]; other site 1206780004672 active site pocket [active] 1206780004673 cleavage site 1206780004674 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1206780004675 feedback inhibition sensing region; other site 1206780004676 homohexameric interface [polypeptide binding]; other site 1206780004677 nucleotide binding site [chemical binding]; other site 1206780004678 N-acetyl-L-glutamate binding site [chemical binding]; other site 1206780004679 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1206780004680 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1206780004681 inhibitor-cofactor binding pocket; inhibition site 1206780004682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780004683 catalytic residue [active] 1206780004684 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1206780004685 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1206780004686 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1206780004687 arginine repressor; Provisional; Region: PRK03341 1206780004688 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1206780004689 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1206780004690 argininosuccinate synthase; Provisional; Region: PRK13820 1206780004691 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1206780004692 ANP binding site [chemical binding]; other site 1206780004693 Substrate Binding Site II [chemical binding]; other site 1206780004694 Substrate Binding Site I [chemical binding]; other site 1206780004695 argininosuccinate lyase; Provisional; Region: PRK00855 1206780004696 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1206780004697 active sites [active] 1206780004698 tetramer interface [polypeptide binding]; other site 1206780004699 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1206780004700 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1206780004701 malonyl-CoA binding site [chemical binding]; other site 1206780004702 dimer interface [polypeptide binding]; other site 1206780004703 active site 1206780004704 product binding site; other site 1206780004705 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1206780004706 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780004707 active site 1206780004708 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1206780004709 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1206780004710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780004711 Enoylreductase; Region: PKS_ER; smart00829 1206780004712 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1206780004713 NAD(P) binding site [chemical binding]; other site 1206780004714 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1206780004715 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1206780004716 putative NADP binding site [chemical binding]; other site 1206780004717 active site 1206780004718 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780004719 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1206780004720 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780004721 active site 1206780004722 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1206780004723 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1206780004724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780004725 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1206780004726 Enoylreductase; Region: PKS_ER; smart00829 1206780004727 NAD(P) binding site [chemical binding]; other site 1206780004728 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1206780004729 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1206780004730 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1206780004731 putative NADP binding site [chemical binding]; other site 1206780004732 active site 1206780004733 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780004734 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1206780004735 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780004736 active site 1206780004737 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1206780004738 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1206780004739 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780004740 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1206780004741 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1206780004742 malonyl-CoA binding site [chemical binding]; other site 1206780004743 dimer interface [polypeptide binding]; other site 1206780004744 active site 1206780004745 product binding site; other site 1206780004746 Cytochrome P450; Region: p450; cl12078 1206780004747 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780004748 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1206780004749 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206780004750 ABC transporter; Region: ABC_tran_2; pfam12848 1206780004751 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206780004752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1206780004753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780004754 putative substrate translocation pore; other site 1206780004755 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1206780004756 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1206780004757 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206780004758 dimerization interface [polypeptide binding]; other site 1206780004759 putative DNA binding site [nucleotide binding]; other site 1206780004760 putative Zn2+ binding site [ion binding]; other site 1206780004761 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1206780004762 active site residue [active] 1206780004763 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1206780004764 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1206780004765 ligand binding site [chemical binding]; other site 1206780004766 flexible hinge region; other site 1206780004767 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1206780004768 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1206780004769 putative catalytic residues [active] 1206780004770 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1206780004771 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1206780004772 catalytic residues [active] 1206780004773 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780004774 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780004775 active site 1206780004776 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1206780004777 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1206780004778 substrate binding pocket [chemical binding]; other site 1206780004779 membrane-bound complex binding site; other site 1206780004780 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1206780004781 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206780004782 FeS/SAM binding site; other site 1206780004783 DivIVA protein; Region: DivIVA; pfam05103 1206780004784 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1206780004785 acyl-CoA synthetase; Validated; Region: PRK07868 1206780004786 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1206780004787 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780004788 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780004789 acyl-activating enzyme (AAE) consensus motif; other site 1206780004790 AMP binding site [chemical binding]; other site 1206780004791 active site 1206780004792 CoA binding site [chemical binding]; other site 1206780004793 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1206780004794 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780004795 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780004796 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1206780004797 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1206780004798 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1206780004799 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1206780004800 Walker A/P-loop; other site 1206780004801 ATP binding site [chemical binding]; other site 1206780004802 Q-loop/lid; other site 1206780004803 ABC transporter signature motif; other site 1206780004804 Walker B; other site 1206780004805 D-loop; other site 1206780004806 H-loop/switch region; other site 1206780004807 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1206780004808 active site 1206780004809 DNA binding site [nucleotide binding] 1206780004810 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1206780004811 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1206780004812 active site 1206780004813 HIGH motif; other site 1206780004814 dimer interface [polypeptide binding]; other site 1206780004815 KMSKS motif; other site 1206780004816 S4 RNA-binding domain; Region: S4; smart00363 1206780004817 RNA binding surface [nucleotide binding]; other site 1206780004818 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1206780004819 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1206780004820 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1206780004821 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1206780004822 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1206780004823 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1206780004824 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1206780004825 RNA binding surface [nucleotide binding]; other site 1206780004826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780004827 S-adenosylmethionine binding site [chemical binding]; other site 1206780004828 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1206780004829 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1206780004830 DNA repair protein RecN; Region: recN; TIGR00634 1206780004831 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1206780004832 Walker A/P-loop; other site 1206780004833 ATP binding site [chemical binding]; other site 1206780004834 Q-loop/lid; other site 1206780004835 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1206780004836 ABC transporter signature motif; other site 1206780004837 Walker B; other site 1206780004838 D-loop; other site 1206780004839 H-loop/switch region; other site 1206780004840 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1206780004841 Thiamine pyrophosphokinase; Region: TPK; cl08415 1206780004842 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1206780004843 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1206780004844 CTP synthetase; Validated; Region: pyrG; PRK05380 1206780004845 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1206780004846 Catalytic site [active] 1206780004847 active site 1206780004848 UTP binding site [chemical binding]; other site 1206780004849 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1206780004850 active site 1206780004851 putative oxyanion hole; other site 1206780004852 catalytic triad [active] 1206780004853 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1206780004854 dimer interface [polypeptide binding]; other site 1206780004855 ADP-ribose binding site [chemical binding]; other site 1206780004856 active site 1206780004857 nudix motif; other site 1206780004858 metal binding site [ion binding]; metal-binding site 1206780004859 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1206780004860 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1206780004861 active site 1206780004862 DNA binding site [nucleotide binding] 1206780004863 Int/Topo IB signature motif; other site 1206780004864 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780004865 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780004866 active site 1206780004867 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1206780004868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780004869 S-adenosylmethionine binding site [chemical binding]; other site 1206780004870 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1206780004871 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780004872 PPE family; Region: PPE; pfam00823 1206780004873 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780004874 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780004875 PPE family; Region: PPE; pfam00823 1206780004876 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780004877 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1206780004878 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1206780004879 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1206780004880 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1206780004881 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206780004882 P-loop; other site 1206780004883 Magnesium ion binding site [ion binding]; other site 1206780004884 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206780004885 Magnesium ion binding site [ion binding]; other site 1206780004886 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1206780004887 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1206780004888 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1206780004889 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1206780004890 RNA binding surface [nucleotide binding]; other site 1206780004891 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1206780004892 active site 1206780004893 cytidylate kinase; Provisional; Region: cmk; PRK00023 1206780004894 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1206780004895 CMP-binding site; other site 1206780004896 The sites determining sugar specificity; other site 1206780004897 GTP-binding protein Der; Reviewed; Region: PRK03003 1206780004898 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1206780004899 GTP/Mg2+ binding site [chemical binding]; other site 1206780004900 Switch I region; other site 1206780004901 G2 box; other site 1206780004902 Switch II region; other site 1206780004903 G3 box; other site 1206780004904 G4 box; other site 1206780004905 G5 box; other site 1206780004906 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1206780004907 G1 box; other site 1206780004908 GTP/Mg2+ binding site [chemical binding]; other site 1206780004909 Switch I region; other site 1206780004910 G2 box; other site 1206780004911 G3 box; other site 1206780004912 Switch II region; other site 1206780004913 G4 box; other site 1206780004914 G5 box; other site 1206780004915 short chain dehydrogenase; Provisional; Region: PRK07060 1206780004916 classical (c) SDRs; Region: SDR_c; cd05233 1206780004917 NAD(P) binding site [chemical binding]; other site 1206780004918 active site 1206780004919 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1206780004920 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1206780004921 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1206780004922 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1206780004923 Cupin domain; Region: Cupin_2; pfam07883 1206780004924 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1206780004925 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1206780004926 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1206780004927 putative switch regulator; other site 1206780004928 non-specific DNA interactions [nucleotide binding]; other site 1206780004929 DNA binding site [nucleotide binding] 1206780004930 sequence specific DNA binding site [nucleotide binding]; other site 1206780004931 putative cAMP binding site [chemical binding]; other site 1206780004932 Bacterial transcriptional regulator; Region: IclR; pfam01614 1206780004933 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1206780004934 putative active site [active] 1206780004935 homotetrameric interface [polypeptide binding]; other site 1206780004936 metal binding site [ion binding]; metal-binding site 1206780004937 biotin carboxylase-like protein; Validated; Region: PRK06524 1206780004938 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1206780004939 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1206780004940 Beta-lactamase; Region: Beta-lactamase; pfam00144 1206780004941 Predicted transcriptional regulators [Transcription]; Region: COG1733 1206780004942 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206780004943 dimerization interface [polypeptide binding]; other site 1206780004944 putative DNA binding site [nucleotide binding]; other site 1206780004945 putative Zn2+ binding site [ion binding]; other site 1206780004946 Predicted transcriptional regulators [Transcription]; Region: COG1733 1206780004947 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1206780004948 FAD binding domain; Region: FAD_binding_4; pfam01565 1206780004949 Berberine and berberine like; Region: BBE; pfam08031 1206780004950 TIGR03086 family protein; Region: TIGR03086 1206780004951 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1206780004952 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1206780004953 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1206780004954 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1206780004955 Beta-lactamase; Region: Beta-lactamase; pfam00144 1206780004956 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1206780004957 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1206780004958 NAD(P) binding site [chemical binding]; other site 1206780004959 catalytic residues [active] 1206780004960 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1206780004961 putative catalytic residue [active] 1206780004962 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1206780004963 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1206780004964 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1206780004965 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1206780004966 gating phenylalanine in ion channel; other site 1206780004967 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1206780004968 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1206780004969 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1206780004970 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1206780004971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780004972 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1206780004973 putative substrate translocation pore; other site 1206780004974 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1206780004975 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1206780004976 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1206780004977 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1206780004978 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1206780004979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1206780004980 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1206780004981 putative active site [active] 1206780004982 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1206780004983 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1206780004984 active site 1206780004985 ATP binding site [chemical binding]; other site 1206780004986 substrate binding site [chemical binding]; other site 1206780004987 activation loop (A-loop); other site 1206780004988 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1206780004989 Thioredoxin; Region: Thioredoxin_4; cl17273 1206780004990 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1206780004991 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1206780004992 active site 1206780004993 metal binding site [ion binding]; metal-binding site 1206780004994 nudix motif; other site 1206780004995 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1206780004996 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1206780004997 active site 1206780004998 ATP binding site [chemical binding]; other site 1206780004999 substrate binding site [chemical binding]; other site 1206780005000 activation loop (A-loop); other site 1206780005001 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1206780005002 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1206780005003 phosphopeptide binding site; other site 1206780005004 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1206780005005 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1206780005006 phosphopeptide binding site; other site 1206780005007 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1206780005008 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 1206780005009 Walker A/P-loop; other site 1206780005010 ATP binding site [chemical binding]; other site 1206780005011 Q-loop/lid; other site 1206780005012 ABC transporter signature motif; other site 1206780005013 Walker B; other site 1206780005014 D-loop; other site 1206780005015 H-loop/switch region; other site 1206780005016 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1206780005017 acyl-CoA synthetase; Provisional; Region: PRK13388 1206780005018 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780005019 acyl-activating enzyme (AAE) consensus motif; other site 1206780005020 AMP binding site [chemical binding]; other site 1206780005021 active site 1206780005022 CoA binding site [chemical binding]; other site 1206780005023 hypothetical protein; Provisional; Region: PRK06185 1206780005024 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1206780005025 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1206780005026 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1206780005027 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780005028 PPE family; Region: PPE; pfam00823 1206780005029 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780005030 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780005031 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1206780005032 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1206780005033 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1206780005034 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206780005035 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1206780005036 sulfite oxidase; Provisional; Region: PLN00177 1206780005037 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1206780005038 Moco binding site; other site 1206780005039 metal coordination site [ion binding]; other site 1206780005040 dimerization interface [polypeptide binding]; other site 1206780005041 Transport protein; Region: actII; TIGR00833 1206780005042 Cutinase; Region: Cutinase; pfam01083 1206780005043 PE family; Region: PE; pfam00934 1206780005044 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1206780005045 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1206780005046 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1206780005047 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1206780005048 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1206780005049 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1206780005050 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780005051 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780005052 active site 1206780005053 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1206780005054 FAD binding domain; Region: FAD_binding_4; pfam01565 1206780005055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780005056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780005057 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780005058 Cytochrome P450; Region: p450; cl12078 1206780005059 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1206780005060 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1206780005061 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1206780005062 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1206780005063 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206780005064 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1206780005065 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206780005066 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780005067 Cytochrome P450; Region: p450; cl12078 1206780005068 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1206780005069 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780005070 PPE family; Region: PPE; pfam00823 1206780005071 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780005072 PE family; Region: PE; pfam00934 1206780005073 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780005074 PPE family; Region: PPE; pfam00823 1206780005075 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780005076 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780005077 PPE family; Region: PPE; pfam00823 1206780005078 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780005079 PE family; Region: PE; pfam00934 1206780005080 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1206780005081 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1206780005082 EspG family; Region: ESX-1_EspG; pfam14011 1206780005083 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1206780005084 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1206780005085 catalytic residues [active] 1206780005086 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1206780005087 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1206780005088 active site 1206780005089 catalytic residues [active] 1206780005090 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1206780005091 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1206780005092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780005093 Walker A motif; other site 1206780005094 ATP binding site [chemical binding]; other site 1206780005095 Walker B motif; other site 1206780005096 arginine finger; other site 1206780005097 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780005098 PPE family; Region: PPE; pfam00823 1206780005099 PE-PPE domain; Region: PE-PPE; pfam08237 1206780005100 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780005101 PPE family; Region: PPE; pfam00823 1206780005102 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780005103 PPE family; Region: PPE; pfam00823 1206780005104 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1206780005105 PE family; Region: PE; pfam00934 1206780005106 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780005107 PPE family; Region: PPE; pfam00823 1206780005108 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780005109 PPE family; Region: PPE; pfam00823 1206780005110 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780005111 PPE family; Region: PPE; pfam00823 1206780005112 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1206780005113 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1206780005114 MgtC family; Region: MgtC; pfam02308 1206780005115 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1206780005116 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206780005117 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1206780005118 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1206780005119 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1206780005120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780005121 hypothetical protein; Validated; Region: PRK07121 1206780005122 PE family; Region: PE; pfam00934 1206780005123 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1206780005124 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 1206780005125 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1206780005126 hypothetical protein; Provisional; Region: PRK05858 1206780005127 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1206780005128 PYR/PP interface [polypeptide binding]; other site 1206780005129 dimer interface [polypeptide binding]; other site 1206780005130 TPP binding site [chemical binding]; other site 1206780005131 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1206780005132 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1206780005133 TPP-binding site; other site 1206780005134 dimer interface [polypeptide binding]; other site 1206780005135 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1206780005136 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1206780005137 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1206780005138 nucleotide binding region [chemical binding]; other site 1206780005139 ATP-binding site [chemical binding]; other site 1206780005140 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1206780005141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1206780005142 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1206780005143 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 1206780005144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1206780005145 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1206780005146 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1206780005147 lipoyl attachment site [posttranslational modification]; other site 1206780005148 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1206780005149 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1206780005150 phosphopeptide binding site; other site 1206780005151 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1206780005152 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1206780005153 DNA binding residues [nucleotide binding] 1206780005154 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1206780005155 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1206780005156 DNA binding residues [nucleotide binding] 1206780005157 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1206780005158 putative dimer interface [polypeptide binding]; other site 1206780005159 glycine dehydrogenase; Provisional; Region: PRK05367 1206780005160 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1206780005161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780005162 tetramer interface [polypeptide binding]; other site 1206780005163 catalytic residue [active] 1206780005164 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1206780005165 tetramer interface [polypeptide binding]; other site 1206780005166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780005167 catalytic residue [active] 1206780005168 haloalkane dehalogenase; Provisional; Region: PRK03204 1206780005169 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1206780005170 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1206780005171 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1206780005172 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1206780005173 metal ion-dependent adhesion site (MIDAS); other site 1206780005174 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1206780005175 active site 1206780005176 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1206780005177 putative active site [active] 1206780005178 Domain of unknown function DUF21; Region: DUF21; pfam01595 1206780005179 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1206780005180 FOG: CBS domain [General function prediction only]; Region: COG0517 1206780005181 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1206780005182 Domain of unknown function DUF21; Region: DUF21; pfam01595 1206780005183 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1206780005184 Transporter associated domain; Region: CorC_HlyC; smart01091 1206780005185 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1206780005186 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1206780005187 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1206780005188 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1206780005189 active site 1206780005190 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1206780005191 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1206780005192 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1206780005193 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1206780005194 Predicted transcriptional regulator [Transcription]; Region: COG3682 1206780005195 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1206780005196 CoenzymeA binding site [chemical binding]; other site 1206780005197 subunit interaction site [polypeptide binding]; other site 1206780005198 PHB binding site; other site 1206780005199 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1206780005200 alpha-gamma subunit interface [polypeptide binding]; other site 1206780005201 beta-gamma subunit interface [polypeptide binding]; other site 1206780005202 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1206780005203 gamma-beta subunit interface [polypeptide binding]; other site 1206780005204 alpha-beta subunit interface [polypeptide binding]; other site 1206780005205 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1206780005206 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1206780005207 subunit interactions [polypeptide binding]; other site 1206780005208 active site 1206780005209 flap region; other site 1206780005210 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1206780005211 UreF; Region: UreF; pfam01730 1206780005212 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1206780005213 UreD urease accessory protein; Region: UreD; cl00530 1206780005214 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1206780005215 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206780005216 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1206780005217 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1206780005218 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1206780005219 classical (c) SDRs; Region: SDR_c; cd05233 1206780005220 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1206780005221 NAD(P) binding site [chemical binding]; other site 1206780005222 active site 1206780005223 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1206780005224 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1206780005225 sulfate transport protein; Provisional; Region: cysT; CHL00187 1206780005226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780005227 dimer interface [polypeptide binding]; other site 1206780005228 conserved gate region; other site 1206780005229 putative PBP binding loops; other site 1206780005230 ABC-ATPase subunit interface; other site 1206780005231 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1206780005232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206780005233 Walker A/P-loop; other site 1206780005234 ATP binding site [chemical binding]; other site 1206780005235 Q-loop/lid; other site 1206780005236 ABC transporter signature motif; other site 1206780005237 Walker B; other site 1206780005238 D-loop; other site 1206780005239 H-loop/switch region; other site 1206780005240 TOBE domain; Region: TOBE; pfam03459 1206780005241 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1206780005242 Predicted membrane protein [Function unknown]; Region: COG2261 1206780005243 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1206780005244 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1206780005245 putative NAD(P) binding site [chemical binding]; other site 1206780005246 putative substrate binding site [chemical binding]; other site 1206780005247 catalytic Zn binding site [ion binding]; other site 1206780005248 structural Zn binding site [ion binding]; other site 1206780005249 CAAX protease self-immunity; Region: Abi; pfam02517 1206780005250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1206780005251 MOSC domain; Region: MOSC; pfam03473 1206780005252 short chain dehydrogenase; Provisional; Region: PRK07825 1206780005253 classical (c) SDRs; Region: SDR_c; cd05233 1206780005254 NAD(P) binding site [chemical binding]; other site 1206780005255 active site 1206780005256 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1206780005257 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1206780005258 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1206780005259 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1206780005260 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1206780005261 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1206780005262 active site 1206780005263 hypothetical protein; Provisional; Region: PRK12320 1206780005264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780005265 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1206780005266 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206780005267 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206780005268 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1206780005269 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1206780005270 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1206780005271 active site 1206780005272 substrate binding site [chemical binding]; other site 1206780005273 FMN binding site [chemical binding]; other site 1206780005274 putative catalytic residues [active] 1206780005275 Uncharacterized conserved protein [Function unknown]; Region: COG5579 1206780005276 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1206780005277 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 1206780005278 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1206780005279 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1206780005280 heme binding site [chemical binding]; other site 1206780005281 ferroxidase pore; other site 1206780005282 ferroxidase diiron center [ion binding]; other site 1206780005283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780005284 putative substrate translocation pore; other site 1206780005285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780005286 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 1206780005287 23S rRNA interface [nucleotide binding]; other site 1206780005288 L3 interface [polypeptide binding]; other site 1206780005289 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1206780005290 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1206780005291 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1206780005292 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1206780005293 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780005294 Cytochrome P450; Region: p450; cl12078 1206780005295 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1206780005296 short chain dehydrogenase; Provisional; Region: PRK08267 1206780005297 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 1206780005298 putative NAD(P) binding site [chemical binding]; other site 1206780005299 active site 1206780005300 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1206780005301 hydrophobic ligand binding site; other site 1206780005302 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1206780005303 chorismate mutase; Provisional; Region: PRK09269 1206780005304 chorismate mutase, putative; Region: CM_mono2; TIGR01806 1206780005305 Putative esterase; Region: Esterase; pfam00756 1206780005306 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1206780005307 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1206780005308 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1206780005309 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1206780005310 Nitronate monooxygenase; Region: NMO; pfam03060 1206780005311 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1206780005312 FMN binding site [chemical binding]; other site 1206780005313 substrate binding site [chemical binding]; other site 1206780005314 putative catalytic residue [active] 1206780005315 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1206780005316 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1206780005317 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1206780005318 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1206780005319 NAD(P) binding site [chemical binding]; other site 1206780005320 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1206780005321 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1206780005322 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 1206780005323 putative active site [active] 1206780005324 dimerization interface [polypeptide binding]; other site 1206780005325 putative tRNAtyr binding site [nucleotide binding]; other site 1206780005326 Domain of unknown function DUF77; Region: DUF77; pfam01910 1206780005327 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 1206780005328 putative ADP-ribose binding site [chemical binding]; other site 1206780005329 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206780005330 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1206780005331 cyclase homology domain; Region: CHD; cd07302 1206780005332 nucleotidyl binding site; other site 1206780005333 metal binding site [ion binding]; metal-binding site 1206780005334 dimer interface [polypeptide binding]; other site 1206780005335 competence damage-inducible protein A; Provisional; Region: PRK00549 1206780005336 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1206780005337 putative MPT binding site; other site 1206780005338 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1206780005339 putative sialic acid transporter; Region: 2A0112; TIGR00891 1206780005340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780005341 putative substrate translocation pore; other site 1206780005342 Predicted membrane protein [Function unknown]; Region: COG1950 1206780005343 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1206780005344 anti sigma factor interaction site; other site 1206780005345 regulatory phosphorylation site [posttranslational modification]; other site 1206780005346 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1206780005347 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1206780005348 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1206780005349 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1206780005350 dimer interface [polypeptide binding]; other site 1206780005351 active site 1206780005352 heme binding site [chemical binding]; other site 1206780005353 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1206780005354 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1206780005355 metal binding site 2 [ion binding]; metal-binding site 1206780005356 putative DNA binding helix; other site 1206780005357 metal binding site 1 [ion binding]; metal-binding site 1206780005358 dimer interface [polypeptide binding]; other site 1206780005359 structural Zn2+ binding site [ion binding]; other site 1206780005360 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1206780005361 substrate binding site [chemical binding]; other site 1206780005362 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1206780005363 substrate binding site [chemical binding]; other site 1206780005364 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1206780005365 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 1206780005366 putative NAD(P) binding site [chemical binding]; other site 1206780005367 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1206780005368 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1206780005369 tetramer interface [polypeptide binding]; other site 1206780005370 active site 1206780005371 Mg2+/Mn2+ binding site [ion binding]; other site 1206780005372 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1206780005373 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780005374 PPE family; Region: PPE; pfam00823 1206780005375 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780005376 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780005377 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780005378 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780005379 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780005380 PPE family; Region: PPE; pfam00823 1206780005381 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780005382 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780005383 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1206780005384 putative hydrophobic ligand binding site [chemical binding]; other site 1206780005385 protein interface [polypeptide binding]; other site 1206780005386 gate; other site 1206780005387 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1206780005388 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1206780005389 putative acyl-acceptor binding pocket; other site 1206780005390 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1206780005391 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1206780005392 Beta-lactamase; Region: Beta-lactamase; pfam00144 1206780005393 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1206780005394 Beta-lactamase; Region: Beta-lactamase; pfam00144 1206780005395 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1206780005396 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1206780005397 acyl-activating enzyme (AAE) consensus motif; other site 1206780005398 active site 1206780005399 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1206780005400 Uncharacterized conserved protein [Function unknown]; Region: COG3361 1206780005401 short chain dehydrogenase; Provisional; Region: PRK05867 1206780005402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780005403 NAD(P) binding site [chemical binding]; other site 1206780005404 active site 1206780005405 TIGR03085 family protein; Region: TIGR03085 1206780005406 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1206780005407 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1206780005408 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1206780005409 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1206780005410 conserved cys residue [active] 1206780005411 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1206780005412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206780005413 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1206780005414 dimer interface [polypeptide binding]; other site 1206780005415 catalytic triad [active] 1206780005416 peroxidatic and resolving cysteines [active] 1206780005417 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780005418 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1206780005419 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1206780005420 active site 1206780005421 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780005422 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1206780005423 FAD binding site [chemical binding]; other site 1206780005424 substrate binding site [chemical binding]; other site 1206780005425 catalytic base [active] 1206780005426 enoyl-CoA hydratase; Provisional; Region: PRK08290 1206780005427 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780005428 substrate binding site [chemical binding]; other site 1206780005429 oxyanion hole (OAH) forming residues; other site 1206780005430 trimer interface [polypeptide binding]; other site 1206780005431 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1206780005432 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1206780005433 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1206780005434 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1206780005435 catalytic loop [active] 1206780005436 iron binding site [ion binding]; other site 1206780005437 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1206780005438 FAD binding pocket [chemical binding]; other site 1206780005439 FAD binding motif [chemical binding]; other site 1206780005440 phosphate binding motif [ion binding]; other site 1206780005441 beta-alpha-beta structure motif; other site 1206780005442 NAD binding pocket [chemical binding]; other site 1206780005443 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206780005444 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1206780005445 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1206780005446 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1206780005447 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1206780005448 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 1206780005449 dimerization interface [polypeptide binding]; other site 1206780005450 active site 1206780005451 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 1206780005452 putative NAD(P) binding site [chemical binding]; other site 1206780005453 active site 1206780005454 homodimer interface [polypeptide binding]; other site 1206780005455 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1206780005456 SEC-C motif; Region: SEC-C; pfam02810 1206780005457 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780005458 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780005459 active site 1206780005460 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1206780005461 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1206780005462 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1206780005463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206780005464 non-specific DNA binding site [nucleotide binding]; other site 1206780005465 salt bridge; other site 1206780005466 sequence-specific DNA binding site [nucleotide binding]; other site 1206780005467 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1206780005468 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 1206780005469 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1206780005470 putative active site [active] 1206780005471 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1206780005472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780005473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780005474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780005475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780005476 Permease; Region: Permease; cl00510 1206780005477 Ribosomal RNA adenine dimethylases; Region: rADc; smart00650 1206780005478 Uncharacterized conserved protein [Function unknown]; Region: COG5654 1206780005479 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1206780005480 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1206780005481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780005482 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1206780005483 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1206780005484 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1206780005485 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206780005486 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1206780005487 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206780005488 dimerization interface [polypeptide binding]; other site 1206780005489 putative DNA binding site [nucleotide binding]; other site 1206780005490 putative Zn2+ binding site [ion binding]; other site 1206780005491 Hemerythrin-like domain; Region: Hr-like; cd12108 1206780005492 Fe binding site [ion binding]; other site 1206780005493 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206780005494 Ligand Binding Site [chemical binding]; other site 1206780005495 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206780005496 Ligand Binding Site [chemical binding]; other site 1206780005497 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1206780005498 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1206780005499 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206780005500 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1206780005501 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1206780005502 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1206780005503 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1206780005504 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1206780005505 tetramer interface [polypeptide binding]; other site 1206780005506 active site 1206780005507 Mg2+/Mn2+ binding site [ion binding]; other site 1206780005508 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1206780005509 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1206780005510 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1206780005511 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1206780005512 homotetramer interface [polypeptide binding]; other site 1206780005513 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1206780005514 NAD binding site [chemical binding]; other site 1206780005515 homodimer interface [polypeptide binding]; other site 1206780005516 active site 1206780005517 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206780005518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780005519 S-adenosylmethionine binding site [chemical binding]; other site 1206780005520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1206780005521 Predicted kinase [General function prediction only]; Region: COG0645 1206780005522 AAA domain; Region: AAA_17; pfam13207 1206780005523 Universal stress protein family; Region: Usp; pfam00582 1206780005524 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206780005525 Ligand Binding Site [chemical binding]; other site 1206780005526 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1206780005527 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1206780005528 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1206780005529 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1206780005530 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1206780005531 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1206780005532 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1206780005533 Ferredoxin [Energy production and conversion]; Region: COG1146 1206780005534 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1206780005535 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1206780005536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780005537 Walker A motif; other site 1206780005538 ATP binding site [chemical binding]; other site 1206780005539 Walker B motif; other site 1206780005540 arginine finger; other site 1206780005541 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1206780005542 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1206780005543 putative active site [active] 1206780005544 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1206780005545 MarR family; Region: MarR_2; pfam12802 1206780005546 Phage envelope protein [General function prediction only]; Region: COG5562 1206780005547 Predicted helicase [General function prediction only]; Region: COG4889 1206780005548 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1206780005549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1206780005550 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1206780005551 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1206780005552 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780005553 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780005554 active site 1206780005555 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206780005556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206780005557 non-specific DNA binding site [nucleotide binding]; other site 1206780005558 salt bridge; other site 1206780005559 sequence-specific DNA binding site [nucleotide binding]; other site 1206780005560 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1206780005561 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1206780005562 Predicted helicase [General function prediction only]; Region: COG4889 1206780005563 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206780005564 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206780005565 non-specific DNA binding site [nucleotide binding]; other site 1206780005566 salt bridge; other site 1206780005567 sequence-specific DNA binding site [nucleotide binding]; other site 1206780005568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1206780005569 Predicted helicase [General function prediction only]; Region: COG4889 1206780005570 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1206780005571 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1206780005572 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206780005573 ATP binding site [chemical binding]; other site 1206780005574 putative Mg++ binding site [ion binding]; other site 1206780005575 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1206780005576 ATP-binding site [chemical binding]; other site 1206780005577 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1206780005578 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1206780005579 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1206780005580 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206780005581 Ligand Binding Site [chemical binding]; other site 1206780005582 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206780005583 Ligand Binding Site [chemical binding]; other site 1206780005584 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1206780005585 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1206780005586 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1206780005587 Histidine kinase; Region: HisKA_3; pfam07730 1206780005588 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206780005589 Ligand Binding Site [chemical binding]; other site 1206780005590 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1206780005591 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1206780005592 putative substrate binding site [chemical binding]; other site 1206780005593 putative ATP binding site [chemical binding]; other site 1206780005594 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206780005595 active site 1206780005596 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1206780005597 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1206780005598 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1206780005599 putative dimer interface [polypeptide binding]; other site 1206780005600 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1206780005601 dimer interface [polypeptide binding]; other site 1206780005602 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1206780005603 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206780005604 putative DNA binding site [nucleotide binding]; other site 1206780005605 dimerization interface [polypeptide binding]; other site 1206780005606 putative Zn2+ binding site [ion binding]; other site 1206780005607 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1206780005608 putative hydrophobic ligand binding site [chemical binding]; other site 1206780005609 CLM binding site; other site 1206780005610 L1 loop; other site 1206780005611 DNA binding site [nucleotide binding] 1206780005612 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1206780005613 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1206780005614 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1206780005615 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1206780005616 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1206780005617 nucleophile elbow; other site 1206780005618 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1206780005619 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1206780005620 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1206780005621 Walker A/P-loop; other site 1206780005622 ATP binding site [chemical binding]; other site 1206780005623 Q-loop/lid; other site 1206780005624 ABC transporter signature motif; other site 1206780005625 Walker B; other site 1206780005626 D-loop; other site 1206780005627 H-loop/switch region; other site 1206780005628 TOBE domain; Region: TOBE_2; pfam08402 1206780005629 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1206780005630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780005631 dimer interface [polypeptide binding]; other site 1206780005632 conserved gate region; other site 1206780005633 putative PBP binding loops; other site 1206780005634 ABC-ATPase subunit interface; other site 1206780005635 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1206780005636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780005637 dimer interface [polypeptide binding]; other site 1206780005638 conserved gate region; other site 1206780005639 putative PBP binding loops; other site 1206780005640 ABC-ATPase subunit interface; other site 1206780005641 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1206780005642 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1206780005643 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1206780005644 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1206780005645 Isochorismatase family; Region: Isochorismatase; pfam00857 1206780005646 catalytic triad [active] 1206780005647 metal binding site [ion binding]; metal-binding site 1206780005648 conserved cis-peptide bond; other site 1206780005649 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1206780005650 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1206780005651 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1206780005652 substrate binding pocket [chemical binding]; other site 1206780005653 catalytic triad [active] 1206780005654 hypothetical protein; Provisional; Region: PRK05865 1206780005655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780005656 NAD(P) binding site [chemical binding]; other site 1206780005657 active site 1206780005658 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1206780005659 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1206780005660 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780005661 active site 1206780005662 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1206780005663 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1206780005664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780005665 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1206780005666 Enoylreductase; Region: PKS_ER; smart00829 1206780005667 NAD(P) binding site [chemical binding]; other site 1206780005668 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1206780005669 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1206780005670 putative NADP binding site [chemical binding]; other site 1206780005671 active site 1206780005672 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780005673 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1206780005674 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780005675 active site 1206780005676 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1206780005677 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1206780005678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780005679 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1206780005680 Enoylreductase; Region: PKS_ER; smart00829 1206780005681 NAD(P) binding site [chemical binding]; other site 1206780005682 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1206780005683 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1206780005684 putative NADP binding site [chemical binding]; other site 1206780005685 active site 1206780005686 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780005687 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1206780005688 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1206780005689 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1206780005690 putative active site [active] 1206780005691 catalytic triad [active] 1206780005692 putative dimer interface [polypeptide binding]; other site 1206780005693 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1206780005694 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1206780005695 Ligand binding site; other site 1206780005696 Putative Catalytic site; other site 1206780005697 DXD motif; other site 1206780005698 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1206780005699 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1206780005700 active site 1206780005701 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1206780005702 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1206780005703 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1206780005704 30S ribosomal protein S18; Provisional; Region: PRK13401 1206780005705 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1206780005706 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1206780005707 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1206780005708 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1206780005709 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1206780005710 intersubunit interface [polypeptide binding]; other site 1206780005711 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1206780005712 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1206780005713 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1206780005714 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1206780005715 PemK-like protein; Region: PemK; pfam02452 1206780005716 precorrin-3B synthase; Region: CobG; TIGR02435 1206780005717 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1206780005718 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1206780005719 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1206780005720 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1206780005721 active site 1206780005722 SAM binding site [chemical binding]; other site 1206780005723 homodimer interface [polypeptide binding]; other site 1206780005724 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1206780005725 active site 1206780005726 SAM binding site [chemical binding]; other site 1206780005727 homodimer interface [polypeptide binding]; other site 1206780005728 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1206780005729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780005730 S-adenosylmethionine binding site [chemical binding]; other site 1206780005731 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1206780005732 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1206780005733 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1206780005734 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206780005735 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206780005736 DNA binding residues [nucleotide binding] 1206780005737 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1206780005738 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 1206780005739 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1206780005740 active site 1206780005741 SAM binding site [chemical binding]; other site 1206780005742 homodimer interface [polypeptide binding]; other site 1206780005743 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1206780005744 active site 1206780005745 SAM binding site [chemical binding]; other site 1206780005746 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1206780005747 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 1206780005748 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1206780005749 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1206780005750 active site 1206780005751 catalytic site [active] 1206780005752 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1206780005753 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1206780005754 putative transposase OrfB; Reviewed; Region: PHA02517 1206780005755 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1206780005756 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1206780005757 active site 1206780005758 ATP binding site [chemical binding]; other site 1206780005759 substrate binding site [chemical binding]; other site 1206780005760 activation loop (A-loop); other site 1206780005761 PknH-like extracellular domain; Region: PknH_C; pfam14032 1206780005762 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1206780005763 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1206780005764 active site 1206780005765 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 1206780005766 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1206780005767 active site 1206780005768 metal binding site 1 [ion binding]; metal-binding site 1206780005769 putative 5' ssDNA interaction site; other site 1206780005770 metal binding site 3; metal-binding site 1206780005771 metal binding site 2 [ion binding]; metal-binding site 1206780005772 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1206780005773 putative DNA binding site [nucleotide binding]; other site 1206780005774 putative metal binding site [ion binding]; other site 1206780005775 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1206780005776 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1206780005777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206780005778 ATP binding site [chemical binding]; other site 1206780005779 putative Mg++ binding site [ion binding]; other site 1206780005780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206780005781 nucleotide binding region [chemical binding]; other site 1206780005782 ATP-binding site [chemical binding]; other site 1206780005783 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1206780005784 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1206780005785 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1206780005786 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1206780005787 Predicted transcriptional regulator [Transcription]; Region: COG2378 1206780005788 WYL domain; Region: WYL; pfam13280 1206780005789 Predicted transcriptional regulator [Transcription]; Region: COG2378 1206780005790 WYL domain; Region: WYL; pfam13280 1206780005791 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1206780005792 PE family; Region: PE; pfam00934 1206780005793 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780005794 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780005795 active site 1206780005796 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1206780005797 SNF2 Helicase protein; Region: DUF3670; pfam12419 1206780005798 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206780005799 ATP binding site [chemical binding]; other site 1206780005800 putative Mg++ binding site [ion binding]; other site 1206780005801 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206780005802 nucleotide binding region [chemical binding]; other site 1206780005803 ATP-binding site [chemical binding]; other site 1206780005804 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1206780005805 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1206780005806 putative active site [active] 1206780005807 PE family; Region: PE; pfam00934 1206780005808 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780005809 PPE family; Region: PPE; pfam00823 1206780005810 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1206780005811 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1206780005812 active site 1206780005813 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1206780005814 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1206780005815 active site 1206780005816 Pup-like protein; Region: Pup; pfam05639 1206780005817 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1206780005818 proteasome ATPase; Region: pup_AAA; TIGR03689 1206780005819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780005820 Walker A motif; other site 1206780005821 ATP binding site [chemical binding]; other site 1206780005822 Walker B motif; other site 1206780005823 arginine finger; other site 1206780005824 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1206780005825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1206780005826 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1206780005827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780005828 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1206780005829 Predicted membrane protein [Function unknown]; Region: COG3918 1206780005830 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1206780005831 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1206780005832 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1206780005833 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1206780005834 homodimer interface [polypeptide binding]; other site 1206780005835 putative metal binding site [ion binding]; other site 1206780005836 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780005837 PPE family; Region: PPE; pfam00823 1206780005838 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1206780005839 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1206780005840 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1206780005841 substrate binding pocket [chemical binding]; other site 1206780005842 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1206780005843 B12 binding site [chemical binding]; other site 1206780005844 cobalt ligand [ion binding]; other site 1206780005845 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1206780005846 PAC2 family; Region: PAC2; pfam09754 1206780005847 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1206780005848 short chain dehydrogenase; Provisional; Region: PRK05872 1206780005849 classical (c) SDRs; Region: SDR_c; cd05233 1206780005850 NAD(P) binding site [chemical binding]; other site 1206780005851 active site 1206780005852 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1206780005853 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1206780005854 active site 1206780005855 HIGH motif; other site 1206780005856 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1206780005857 active site 1206780005858 KMSKS motif; other site 1206780005859 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1206780005860 putative tRNA binding surface [nucleotide binding]; other site 1206780005861 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1206780005862 active site 1206780005863 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1206780005864 conserved hypothetical protein; Region: TIGR03843 1206780005865 conserved hypothetical protein; Region: TIGR03847 1206780005866 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206780005867 catalytic core [active] 1206780005868 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1206780005869 dihydroorotate dehydrogenase, subfamily 2; Region: pyrD_sub2; TIGR01036 1206780005870 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1206780005871 quinone interaction residues [chemical binding]; other site 1206780005872 active site 1206780005873 catalytic residues [active] 1206780005874 FMN binding site [chemical binding]; other site 1206780005875 substrate binding site [chemical binding]; other site 1206780005876 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1206780005877 substrate binding site [chemical binding]; other site 1206780005878 hypothetical protein; Provisional; Region: PRK07906 1206780005879 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1206780005880 putative metal binding site [ion binding]; other site 1206780005881 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1206780005882 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 1206780005883 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206780005884 active site 1206780005885 DivIVA domain; Region: DivI1A_domain; TIGR03544 1206780005886 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1206780005887 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1206780005888 Predicted integral membrane protein [Function unknown]; Region: COG0762 1206780005889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1206780005890 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1206780005891 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1206780005892 catalytic residue [active] 1206780005893 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1206780005894 uncharacterized protein, YfiH family; Region: TIGR00726 1206780005895 cell division protein FtsZ; Validated; Region: PRK09330 1206780005896 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1206780005897 nucleotide binding site [chemical binding]; other site 1206780005898 SulA interaction site; other site 1206780005899 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1206780005900 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1206780005901 Cell division protein FtsQ; Region: FtsQ; pfam03799 1206780005902 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1206780005903 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1206780005904 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1206780005905 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1206780005906 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1206780005907 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 1206780005908 active site 1206780005909 homodimer interface [polypeptide binding]; other site 1206780005910 cell division protein FtsW; Region: ftsW; TIGR02614 1206780005911 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1206780005912 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1206780005913 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1206780005914 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1206780005915 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1206780005916 Mg++ binding site [ion binding]; other site 1206780005917 putative catalytic motif [active] 1206780005918 putative substrate binding site [chemical binding]; other site 1206780005919 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1206780005920 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1206780005921 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1206780005922 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1206780005923 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1206780005924 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1206780005925 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1206780005926 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780005927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780005928 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1206780005929 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1206780005930 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1206780005931 PE family; Region: PE; pfam00934 1206780005932 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1206780005933 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1206780005934 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1206780005935 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1206780005936 MraW methylase family; Region: Methyltransf_5; pfam01795 1206780005937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1206780005938 MraZ protein; Region: MraZ; pfam02381 1206780005939 MraZ protein; Region: MraZ; pfam02381 1206780005940 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1206780005941 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1206780005942 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1206780005943 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1206780005944 substrate binding pocket [chemical binding]; other site 1206780005945 chain length determination region; other site 1206780005946 substrate-Mg2+ binding site; other site 1206780005947 catalytic residues [active] 1206780005948 aspartate-rich region 1; other site 1206780005949 active site lid residues [active] 1206780005950 aspartate-rich region 2; other site 1206780005951 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1206780005952 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1206780005953 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1206780005954 active site 1206780005955 ATP binding site [chemical binding]; other site 1206780005956 substrate binding site [chemical binding]; other site 1206780005957 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1206780005958 substrate binding site [chemical binding]; other site 1206780005959 activation loop (A-loop); other site 1206780005960 activation loop (A-loop); other site 1206780005961 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1206780005962 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1206780005963 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 1206780005964 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1206780005965 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1206780005966 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1206780005967 putative acyl-acceptor binding pocket; other site 1206780005968 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1206780005969 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1206780005970 P loop; other site 1206780005971 Nucleotide binding site [chemical binding]; other site 1206780005972 DTAP/Switch II; other site 1206780005973 Switch I; other site 1206780005974 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1206780005975 putative hydrophobic ligand binding site [chemical binding]; other site 1206780005976 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1206780005977 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1206780005978 acyl-activating enzyme (AAE) consensus motif; other site 1206780005979 putative AMP binding site [chemical binding]; other site 1206780005980 putative active site [active] 1206780005981 putative CoA binding site [chemical binding]; other site 1206780005982 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1206780005983 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206780005984 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1206780005985 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1206780005986 NlpC/P60 family; Region: NLPC_P60; pfam00877 1206780005987 hypothetical protein; Validated; Region: PRK07883 1206780005988 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1206780005989 active site 1206780005990 catalytic site [active] 1206780005991 substrate binding site [chemical binding]; other site 1206780005992 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1206780005993 GIY-YIG motif/motif A; other site 1206780005994 active site 1206780005995 catalytic site [active] 1206780005996 putative DNA binding site [nucleotide binding]; other site 1206780005997 metal binding site [ion binding]; metal-binding site 1206780005998 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1206780005999 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1206780006000 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1206780006001 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1206780006002 Subunit I/III interface [polypeptide binding]; other site 1206780006003 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1206780006004 Cytochrome c; Region: Cytochrom_C; pfam00034 1206780006005 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1206780006006 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1206780006007 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1206780006008 iron-sulfur cluster [ion binding]; other site 1206780006009 [2Fe-2S] cluster binding site [ion binding]; other site 1206780006010 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1206780006011 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1206780006012 heme bH binding site [chemical binding]; other site 1206780006013 intrachain domain interface; other site 1206780006014 heme bL binding site [chemical binding]; other site 1206780006015 interchain domain interface [polypeptide binding]; other site 1206780006016 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1206780006017 Qo binding site; other site 1206780006018 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1206780006019 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1206780006020 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1206780006021 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1206780006022 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1206780006023 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1206780006024 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1206780006025 dimer interface [polypeptide binding]; other site 1206780006026 active site 1206780006027 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1206780006028 Ligand Binding Site [chemical binding]; other site 1206780006029 Molecular Tunnel; other site 1206780006030 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1206780006031 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1206780006032 substrate binding site [chemical binding]; other site 1206780006033 ATP binding site [chemical binding]; other site 1206780006034 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1206780006035 Glycerate kinase family; Region: Gly_kinase; cl00841 1206780006036 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1206780006037 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1206780006038 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1206780006039 putative dimer interface [polypeptide binding]; other site 1206780006040 active site pocket [active] 1206780006041 putative cataytic base [active] 1206780006042 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 1206780006043 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1206780006044 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1206780006045 homodimer interface [polypeptide binding]; other site 1206780006046 substrate-cofactor binding pocket; other site 1206780006047 catalytic residue [active] 1206780006048 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1206780006049 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1206780006050 cyclase homology domain; Region: CHD; cd07302 1206780006051 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1206780006052 nucleotidyl binding site; other site 1206780006053 metal binding site [ion binding]; metal-binding site 1206780006054 dimer interface [polypeptide binding]; other site 1206780006055 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1206780006056 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1206780006057 interface (dimer of trimers) [polypeptide binding]; other site 1206780006058 Substrate-binding/catalytic site; other site 1206780006059 Zn-binding sites [ion binding]; other site 1206780006060 short chain dehydrogenase; Validated; Region: PRK05855 1206780006061 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1206780006062 classical (c) SDRs; Region: SDR_c; cd05233 1206780006063 NAD(P) binding site [chemical binding]; other site 1206780006064 active site 1206780006065 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1206780006066 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1206780006067 E3 interaction surface; other site 1206780006068 lipoyl attachment site [posttranslational modification]; other site 1206780006069 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1206780006070 E3 interaction surface; other site 1206780006071 lipoyl attachment site [posttranslational modification]; other site 1206780006072 e3 binding domain; Region: E3_binding; pfam02817 1206780006073 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1206780006074 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1206780006075 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1206780006076 putative NAD(P) binding site [chemical binding]; other site 1206780006077 putative active site [active] 1206780006078 lipoate-protein ligase B; Provisional; Region: PRK14345 1206780006079 lipoyl synthase; Provisional; Region: PRK05481 1206780006080 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206780006081 FeS/SAM binding site; other site 1206780006082 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1206780006083 RDD family; Region: RDD; pfam06271 1206780006084 glutamine synthetase, type I; Region: GlnA; TIGR00653 1206780006085 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1206780006086 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1206780006087 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1206780006088 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1206780006089 metal binding triad; other site 1206780006090 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1206780006091 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1206780006092 metal binding triad; other site 1206780006093 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1206780006094 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1206780006095 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1206780006096 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1206780006097 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1206780006098 TAP-like protein; Region: Abhydrolase_4; pfam08386 1206780006099 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1206780006100 TAP-like protein; Region: Abhydrolase_4; pfam08386 1206780006101 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1206780006102 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1206780006103 oligomerization interface [polypeptide binding]; other site 1206780006104 active site 1206780006105 metal binding site [ion binding]; metal-binding site 1206780006106 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1206780006107 putative active site; other site 1206780006108 putative metal binding residues [ion binding]; other site 1206780006109 signature motif; other site 1206780006110 putative triphosphate binding site [ion binding]; other site 1206780006111 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1206780006112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 1206780006113 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1206780006114 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1206780006115 RNA/DNA hybrid binding site [nucleotide binding]; other site 1206780006116 active site 1206780006117 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206780006118 catalytic core [active] 1206780006119 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1206780006120 Putative zinc ribbon domain; Region: DUF164; pfam02591 1206780006121 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1206780006122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1206780006123 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1206780006124 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1206780006125 hypothetical protein; Provisional; Region: PRK07908 1206780006126 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206780006127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780006128 homodimer interface [polypeptide binding]; other site 1206780006129 catalytic residue [active] 1206780006130 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1206780006131 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1206780006132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206780006133 active site 1206780006134 motif I; other site 1206780006135 motif II; other site 1206780006136 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1206780006137 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1206780006138 active site 1206780006139 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1206780006140 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1206780006141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1206780006142 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1206780006143 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1206780006144 dimer interface [polypeptide binding]; other site 1206780006145 catalytic triad [active] 1206780006146 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1206780006147 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1206780006148 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1206780006149 dimer interface [polypeptide binding]; other site 1206780006150 TPP-binding site [chemical binding]; other site 1206780006151 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1206780006152 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1206780006153 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1206780006154 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1206780006155 acyl carrier protein; Provisional; Region: acpP; PRK00982 1206780006156 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1206780006157 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1206780006158 dimer interface [polypeptide binding]; other site 1206780006159 active site 1206780006160 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1206780006161 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1206780006162 dimer interface [polypeptide binding]; other site 1206780006163 active site 1206780006164 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1206780006165 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1206780006166 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1206780006167 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1206780006168 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1206780006169 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780006170 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780006171 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1206780006172 FAD binding domain; Region: FAD_binding_4; pfam01565 1206780006173 diacylglycerol kinase; Reviewed; Region: PRK11914 1206780006174 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1206780006175 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1206780006176 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1206780006177 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1206780006178 Beta-lactamase; Region: Beta-lactamase; pfam00144 1206780006179 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1206780006180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780006181 S-adenosylmethionine binding site [chemical binding]; other site 1206780006182 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1206780006183 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1206780006184 NAD binding site [chemical binding]; other site 1206780006185 catalytic Zn binding site [ion binding]; other site 1206780006186 substrate binding site [chemical binding]; other site 1206780006187 structural Zn binding site [ion binding]; other site 1206780006188 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1206780006189 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1206780006190 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1206780006191 putative active site [active] 1206780006192 catalytic triad [active] 1206780006193 putative dimer interface [polypeptide binding]; other site 1206780006194 short chain dehydrogenase; Provisional; Region: PRK05854 1206780006195 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1206780006196 putative NAD(P) binding site [chemical binding]; other site 1206780006197 active site 1206780006198 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1206780006199 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1206780006200 nucleotide binding site [chemical binding]; other site 1206780006201 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1206780006202 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780006203 Cytochrome P450; Region: p450; cl12078 1206780006204 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1206780006205 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780006206 Cytochrome P450; Region: p450; cl12078 1206780006207 Septum formation; Region: Septum_form; pfam13845 1206780006208 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 1206780006209 Predicted membrane protein [Function unknown]; Region: COG2149 1206780006210 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1206780006211 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780006212 Cytochrome P450; Region: p450; cl12078 1206780006213 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 1206780006214 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1206780006215 putative active site [active] 1206780006216 catalytic site [active] 1206780006217 putative metal binding site [ion binding]; other site 1206780006218 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1206780006219 FAD binding domain; Region: FAD_binding_4; pfam01565 1206780006220 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1206780006221 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1206780006222 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1206780006223 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1206780006224 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1206780006225 dimerization interface [polypeptide binding]; other site 1206780006226 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1206780006227 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1206780006228 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1206780006229 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1206780006230 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1206780006231 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1206780006232 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1206780006233 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 1206780006234 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1206780006235 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1206780006236 active site residue [active] 1206780006237 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1206780006238 active site residue [active] 1206780006239 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1206780006240 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1206780006241 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206780006242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780006243 homodimer interface [polypeptide binding]; other site 1206780006244 catalytic residue [active] 1206780006245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 1206780006246 haloalkane dehalogenase; Provisional; Region: PRK00870 1206780006247 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1206780006248 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1206780006249 active site 1206780006250 catalytic tetrad [active] 1206780006251 heat shock protein 90; Provisional; Region: PRK05218 1206780006252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206780006253 ATP binding site [chemical binding]; other site 1206780006254 Mg2+ binding site [ion binding]; other site 1206780006255 G-X-G motif; other site 1206780006256 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1206780006257 Cutinase; Region: Cutinase; pfam01083 1206780006258 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1206780006259 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1206780006260 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1206780006261 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1206780006262 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1206780006263 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1206780006264 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1206780006265 DNA binding site [nucleotide binding] 1206780006266 active site 1206780006267 Int/Topo IB signature motif; other site 1206780006268 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1206780006269 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1206780006270 DNA binding residues [nucleotide binding] 1206780006271 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 1206780006272 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1206780006273 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1206780006274 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1206780006275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780006276 putative PBP binding loops; other site 1206780006277 ABC-ATPase subunit interface; other site 1206780006278 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1206780006279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780006280 dimer interface [polypeptide binding]; other site 1206780006281 conserved gate region; other site 1206780006282 putative PBP binding loops; other site 1206780006283 ABC-ATPase subunit interface; other site 1206780006284 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1206780006285 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1206780006286 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206780006287 Ligand Binding Site [chemical binding]; other site 1206780006288 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206780006289 Ligand Binding Site [chemical binding]; other site 1206780006290 amino acid transporter; Region: 2A0306; TIGR00909 1206780006291 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1206780006292 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1206780006293 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1206780006294 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206780006295 catalytic residue [active] 1206780006296 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1206780006297 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206780006298 Amidinotransferase; Region: Amidinotransf; pfam02274 1206780006299 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1206780006300 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1206780006301 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1206780006302 putative DNA binding site [nucleotide binding]; other site 1206780006303 putative Zn2+ binding site [ion binding]; other site 1206780006304 AsnC family; Region: AsnC_trans_reg; pfam01037 1206780006305 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1206780006306 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1206780006307 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1206780006308 Walker A/P-loop; other site 1206780006309 ATP binding site [chemical binding]; other site 1206780006310 Q-loop/lid; other site 1206780006311 ABC transporter signature motif; other site 1206780006312 Walker B; other site 1206780006313 D-loop; other site 1206780006314 H-loop/switch region; other site 1206780006315 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1206780006316 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1206780006317 Walker A/P-loop; other site 1206780006318 ATP binding site [chemical binding]; other site 1206780006319 Q-loop/lid; other site 1206780006320 ABC transporter signature motif; other site 1206780006321 Walker B; other site 1206780006322 D-loop; other site 1206780006323 H-loop/switch region; other site 1206780006324 MarR family; Region: MarR; pfam01047 1206780006325 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1206780006326 PE family; Region: PE; pfam00934 1206780006327 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1206780006328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780006329 putative substrate translocation pore; other site 1206780006330 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1206780006331 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1206780006332 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1206780006333 malate dehydrogenase; Provisional; Region: PRK13529 1206780006334 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1206780006335 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1206780006336 NAD(P) binding site [chemical binding]; other site 1206780006337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780006338 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1206780006339 putative substrate translocation pore; other site 1206780006340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780006341 putative substrate translocation pore; other site 1206780006342 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1206780006343 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1206780006344 dimer interface [polypeptide binding]; other site 1206780006345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780006346 catalytic residue [active] 1206780006347 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1206780006348 serine O-acetyltransferase; Region: cysE; TIGR01172 1206780006349 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1206780006350 trimer interface [polypeptide binding]; other site 1206780006351 active site 1206780006352 substrate binding site [chemical binding]; other site 1206780006353 CoA binding site [chemical binding]; other site 1206780006354 hypothetical protein; Provisional; Region: PRK14851 1206780006355 hypothetical protein; Validated; Region: PRK08223 1206780006356 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1206780006357 ATP binding site [chemical binding]; other site 1206780006358 substrate interface [chemical binding]; other site 1206780006359 MMPL family; Region: MMPL; pfam03176 1206780006360 MMPL family; Region: MMPL; pfam03176 1206780006361 Transport protein; Region: actII; TIGR00833 1206780006362 PE family; Region: PE; pfam00934 1206780006363 DNA primase; Validated; Region: dnaG; PRK05667 1206780006364 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1206780006365 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1206780006366 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1206780006367 active site 1206780006368 metal binding site [ion binding]; metal-binding site 1206780006369 interdomain interaction site; other site 1206780006370 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1206780006371 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1206780006372 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1206780006373 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1206780006374 Zn2+ binding site [ion binding]; other site 1206780006375 Mg2+ binding site [ion binding]; other site 1206780006376 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1206780006377 Repair protein; Region: Repair_PSII; pfam04536 1206780006378 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1206780006379 PPE family; Region: PPE; pfam00823 1206780006380 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780006381 PPE family; Region: PPE; pfam00823 1206780006382 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1206780006383 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1206780006384 motif 1; other site 1206780006385 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1206780006386 active site 1206780006387 motif 2; other site 1206780006388 motif 3; other site 1206780006389 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1206780006390 anticodon binding site; other site 1206780006391 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206780006392 dimerization interface [polypeptide binding]; other site 1206780006393 putative DNA binding site [nucleotide binding]; other site 1206780006394 putative Zn2+ binding site [ion binding]; other site 1206780006395 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1206780006396 metal binding site 2 [ion binding]; metal-binding site 1206780006397 putative DNA binding helix; other site 1206780006398 metal binding site 1 [ion binding]; metal-binding site 1206780006399 dimer interface [polypeptide binding]; other site 1206780006400 structural Zn2+ binding site [ion binding]; other site 1206780006401 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1206780006402 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1206780006403 catalytic residue [active] 1206780006404 putative FPP diphosphate binding site; other site 1206780006405 putative FPP binding hydrophobic cleft; other site 1206780006406 dimer interface [polypeptide binding]; other site 1206780006407 putative IPP diphosphate binding site; other site 1206780006408 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1206780006409 Recombination protein O N terminal; Region: RecO_N; pfam11967 1206780006410 Recombination protein O C terminal; Region: RecO_C; pfam02565 1206780006411 amidase; Provisional; Region: PRK06061 1206780006412 Amidase; Region: Amidase; pfam01425 1206780006413 GTPase Era; Reviewed; Region: era; PRK00089 1206780006414 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1206780006415 G1 box; other site 1206780006416 GTP/Mg2+ binding site [chemical binding]; other site 1206780006417 Switch I region; other site 1206780006418 G2 box; other site 1206780006419 Switch II region; other site 1206780006420 G3 box; other site 1206780006421 G4 box; other site 1206780006422 G5 box; other site 1206780006423 KH domain; Region: KH_2; pfam07650 1206780006424 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1206780006425 Domain of unknown function DUF21; Region: DUF21; pfam01595 1206780006426 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1206780006427 Transporter associated domain; Region: CorC_HlyC; smart01091 1206780006428 metal-binding heat shock protein; Provisional; Region: PRK00016 1206780006429 K homology RNA-binding domain; Region: KH; smart00322 1206780006430 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1206780006431 PhoH-like protein; Region: PhoH; pfam02562 1206780006432 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1206780006433 PE family; Region: PE; pfam00934 1206780006434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1206780006435 RNA methyltransferase, RsmE family; Region: TIGR00046 1206780006436 chaperone protein DnaJ; Provisional; Region: PRK14278 1206780006437 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1206780006438 HSP70 interaction site [polypeptide binding]; other site 1206780006439 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1206780006440 Zn binding sites [ion binding]; other site 1206780006441 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1206780006442 dimer interface [polypeptide binding]; other site 1206780006443 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1206780006444 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1206780006445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1206780006446 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206780006447 Condensation domain; Region: Condensation; pfam00668 1206780006448 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1206780006449 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1206780006450 acyl-activating enzyme (AAE) consensus motif; other site 1206780006451 AMP binding site [chemical binding]; other site 1206780006452 Condensation domain; Region: Condensation; pfam00668 1206780006453 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1206780006454 Condensation domain; Region: Condensation; pfam00668 1206780006455 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1206780006456 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1206780006457 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1206780006458 acyl-activating enzyme (AAE) consensus motif; other site 1206780006459 AMP binding site [chemical binding]; other site 1206780006460 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1206780006461 Condensation domain; Region: Condensation; pfam00668 1206780006462 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1206780006463 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1206780006464 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780006465 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1206780006466 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1206780006467 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1206780006468 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1206780006469 NADP binding site [chemical binding]; other site 1206780006470 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1206780006471 active site 1206780006472 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780006473 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780006474 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1206780006475 active site 1206780006476 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1206780006477 Condensation domain; Region: Condensation; pfam00668 1206780006478 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1206780006479 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1206780006480 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1206780006481 acyl-activating enzyme (AAE) consensus motif; other site 1206780006482 AMP binding site [chemical binding]; other site 1206780006483 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1206780006484 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1206780006485 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1206780006486 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1206780006487 acyl-activating enzyme (AAE) consensus motif; other site 1206780006488 active site 1206780006489 AMP binding site [chemical binding]; other site 1206780006490 substrate binding site [chemical binding]; other site 1206780006491 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1206780006492 salicylate synthase MbtI; Reviewed; Region: PRK07912 1206780006493 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1206780006494 Predicted permease [General function prediction only]; Region: COG3329 1206780006495 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1206780006496 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1206780006497 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1206780006498 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1206780006499 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1206780006500 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1206780006501 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1206780006502 Active Sites [active] 1206780006503 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1206780006504 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1206780006505 putative active site [active] 1206780006506 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1206780006507 putative active site [active] 1206780006508 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1206780006509 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1206780006510 OPT oligopeptide transporter protein; Region: OPT; cl14607 1206780006511 OPT oligopeptide transporter protein; Region: OPT; cl14607 1206780006512 PE family; Region: PE; pfam00934 1206780006513 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1206780006514 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1206780006515 Walker A/P-loop; other site 1206780006516 ATP binding site [chemical binding]; other site 1206780006517 Q-loop/lid; other site 1206780006518 ABC transporter signature motif; other site 1206780006519 Walker B; other site 1206780006520 D-loop; other site 1206780006521 H-loop/switch region; other site 1206780006522 sulfate transport protein; Provisional; Region: cysT; CHL00187 1206780006523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780006524 dimer interface [polypeptide binding]; other site 1206780006525 conserved gate region; other site 1206780006526 putative PBP binding loops; other site 1206780006527 ABC-ATPase subunit interface; other site 1206780006528 sulfate transport protein; Provisional; Region: cysT; CHL00187 1206780006529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780006530 dimer interface [polypeptide binding]; other site 1206780006531 conserved gate region; other site 1206780006532 putative PBP binding loops; other site 1206780006533 ABC-ATPase subunit interface; other site 1206780006534 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1206780006535 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1206780006536 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1206780006537 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1206780006538 PknH-like extracellular domain; Region: PknH_C; pfam14032 1206780006539 GTP-binding protein LepA; Provisional; Region: PRK05433 1206780006540 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1206780006541 G1 box; other site 1206780006542 putative GEF interaction site [polypeptide binding]; other site 1206780006543 GTP/Mg2+ binding site [chemical binding]; other site 1206780006544 Switch I region; other site 1206780006545 G2 box; other site 1206780006546 G3 box; other site 1206780006547 Switch II region; other site 1206780006548 G4 box; other site 1206780006549 G5 box; other site 1206780006550 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1206780006551 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1206780006552 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1206780006553 PemK-like protein; Region: PemK; pfam02452 1206780006554 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1206780006555 FOG: CBS domain [General function prediction only]; Region: COG0517 1206780006556 ribonuclease Z; Reviewed; Region: PRK00055 1206780006557 PE family; Region: PE; pfam00934 1206780006558 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1206780006559 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1206780006560 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1206780006561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1206780006562 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1206780006563 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1206780006564 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1206780006565 hypothetical protein; Reviewed; Region: PRK07914 1206780006566 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1206780006567 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1206780006568 Competence protein; Region: Competence; pfam03772 1206780006569 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1206780006570 Helix-hairpin-helix motif; Region: HHH; pfam00633 1206780006571 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1206780006572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206780006573 Coenzyme A binding pocket [chemical binding]; other site 1206780006574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1206780006575 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1206780006576 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1206780006577 active site 1206780006578 catalytic triad [active] 1206780006579 oxyanion hole [active] 1206780006580 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206780006581 catalytic core [active] 1206780006582 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1206780006583 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1206780006584 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1206780006585 active site 1206780006586 (T/H)XGH motif; other site 1206780006587 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206780006588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780006589 S-adenosylmethionine binding site [chemical binding]; other site 1206780006590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1206780006591 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1206780006592 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1206780006593 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1206780006594 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1206780006595 metal ion-dependent adhesion site (MIDAS); other site 1206780006596 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1206780006597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780006598 Walker A motif; other site 1206780006599 ATP binding site [chemical binding]; other site 1206780006600 Walker B motif; other site 1206780006601 arginine finger; other site 1206780006602 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1206780006603 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1206780006604 putative catalytic cysteine [active] 1206780006605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1206780006606 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1206780006607 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1206780006608 dimer interface [polypeptide binding]; other site 1206780006609 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1206780006610 catalytic triad [active] 1206780006611 peroxidatic and resolving cysteines [active] 1206780006612 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1206780006613 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1206780006614 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780006615 PPE family; Region: PPE; pfam00823 1206780006616 PE family; Region: PE; pfam00934 1206780006617 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1206780006618 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1206780006619 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1206780006620 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1206780006621 ligand binding site [chemical binding]; other site 1206780006622 flexible hinge region; other site 1206780006623 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1206780006624 dimerization interface [polypeptide binding]; other site 1206780006625 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1206780006626 cyclase homology domain; Region: CHD; cd07302 1206780006627 nucleotidyl binding site; other site 1206780006628 metal binding site [ion binding]; metal-binding site 1206780006629 dimer interface [polypeptide binding]; other site 1206780006630 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1206780006631 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1206780006632 substrate binding site [chemical binding]; other site 1206780006633 dimer interface [polypeptide binding]; other site 1206780006634 ATP binding site [chemical binding]; other site 1206780006635 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1206780006636 NAD synthetase; Reviewed; Region: nadE; PRK02628 1206780006637 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1206780006638 multimer interface [polypeptide binding]; other site 1206780006639 active site 1206780006640 catalytic triad [active] 1206780006641 protein interface 1 [polypeptide binding]; other site 1206780006642 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1206780006643 homodimer interface [polypeptide binding]; other site 1206780006644 NAD binding pocket [chemical binding]; other site 1206780006645 ATP binding pocket [chemical binding]; other site 1206780006646 Mg binding site [ion binding]; other site 1206780006647 active-site loop [active] 1206780006648 glutamate 5-kinase; Region: proB; TIGR01027 1206780006649 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1206780006650 nucleotide binding site [chemical binding]; other site 1206780006651 homotetrameric interface [polypeptide binding]; other site 1206780006652 putative phosphate binding site [ion binding]; other site 1206780006653 putative allosteric binding site; other site 1206780006654 PUA domain; Region: PUA; pfam01472 1206780006655 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1206780006656 GTP1/OBG; Region: GTP1_OBG; pfam01018 1206780006657 Obg GTPase; Region: Obg; cd01898 1206780006658 G1 box; other site 1206780006659 GTP/Mg2+ binding site [chemical binding]; other site 1206780006660 Switch I region; other site 1206780006661 G2 box; other site 1206780006662 G3 box; other site 1206780006663 Switch II region; other site 1206780006664 G4 box; other site 1206780006665 G5 box; other site 1206780006666 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1206780006667 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1206780006668 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1206780006669 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1206780006670 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1206780006671 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1206780006672 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1206780006673 homodimer interface [polypeptide binding]; other site 1206780006674 oligonucleotide binding site [chemical binding]; other site 1206780006675 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1206780006676 active site 1206780006677 multimer interface [polypeptide binding]; other site 1206780006678 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1206780006679 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1206780006680 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1206780006681 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1206780006682 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1206780006683 active site 1206780006684 HIGH motif; other site 1206780006685 nucleotide binding site [chemical binding]; other site 1206780006686 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1206780006687 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1206780006688 active site 1206780006689 KMSKS motif; other site 1206780006690 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1206780006691 tRNA binding surface [nucleotide binding]; other site 1206780006692 anticodon binding site; other site 1206780006693 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1206780006694 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1206780006695 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1206780006696 NAD(P) binding pocket [chemical binding]; other site 1206780006697 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1206780006698 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1206780006699 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1206780006700 GTP binding site; other site 1206780006701 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1206780006702 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1206780006703 TPP-binding site [chemical binding]; other site 1206780006704 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1206780006705 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1206780006706 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1206780006707 dimer interface [polypeptide binding]; other site 1206780006708 PYR/PP interface [polypeptide binding]; other site 1206780006709 TPP binding site [chemical binding]; other site 1206780006710 substrate binding site [chemical binding]; other site 1206780006711 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1206780006712 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1206780006713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780006714 Walker A motif; other site 1206780006715 ATP binding site [chemical binding]; other site 1206780006716 Walker B motif; other site 1206780006717 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1206780006718 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1206780006719 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1206780006720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780006721 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1206780006722 putative substrate translocation pore; other site 1206780006723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780006724 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1206780006725 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1206780006726 oligomer interface [polypeptide binding]; other site 1206780006727 active site residues [active] 1206780006728 Clp protease; Region: CLP_protease; pfam00574 1206780006729 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1206780006730 oligomer interface [polypeptide binding]; other site 1206780006731 active site residues [active] 1206780006732 trigger factor; Provisional; Region: tig; PRK01490 1206780006733 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1206780006734 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1206780006735 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1206780006736 Beta-lactamase; Region: Beta-lactamase; pfam00144 1206780006737 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1206780006738 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1206780006739 putative DNA binding site [nucleotide binding]; other site 1206780006740 catalytic residue [active] 1206780006741 putative H2TH interface [polypeptide binding]; other site 1206780006742 putative catalytic residues [active] 1206780006743 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1206780006744 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1206780006745 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1206780006746 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1206780006747 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1206780006748 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1206780006749 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1206780006750 Zn binding site [ion binding]; other site 1206780006751 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1206780006752 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780006753 active site 1206780006754 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1206780006755 apolar tunnel; other site 1206780006756 heme binding site [chemical binding]; other site 1206780006757 dimerization interface [polypeptide binding]; other site 1206780006758 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1206780006759 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1206780006760 active site 1206780006761 catalytic site [active] 1206780006762 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1206780006763 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1206780006764 active site 1206780006765 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 1206780006766 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1206780006767 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206780006768 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206780006769 ABC transporter; Region: ABC_tran_2; pfam12848 1206780006770 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1206780006771 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1206780006772 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1206780006773 dimer interface [polypeptide binding]; other site 1206780006774 ssDNA binding site [nucleotide binding]; other site 1206780006775 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1206780006776 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1206780006777 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1206780006778 putative acyl-acceptor binding pocket; other site 1206780006779 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1206780006780 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1206780006781 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1206780006782 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1206780006783 putative acyl-acceptor binding pocket; other site 1206780006784 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1206780006785 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1206780006786 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1206780006787 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1206780006788 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1206780006789 enoyl-CoA hydratase; Provisional; Region: PRK05870 1206780006790 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780006791 substrate binding site [chemical binding]; other site 1206780006792 oxyanion hole (OAH) forming residues; other site 1206780006793 trimer interface [polypeptide binding]; other site 1206780006794 PE family; Region: PE; pfam00934 1206780006795 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1206780006796 cyclase homology domain; Region: CHD; cd07302 1206780006797 nucleotidyl binding site; other site 1206780006798 metal binding site [ion binding]; metal-binding site 1206780006799 dimer interface [polypeptide binding]; other site 1206780006800 Predicted ATPase [General function prediction only]; Region: COG3903 1206780006801 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1206780006802 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1206780006803 DNA binding residues [nucleotide binding] 1206780006804 dimerization interface [polypeptide binding]; other site 1206780006805 PE family; Region: PE; pfam00934 1206780006806 TIGR00725 family protein; Region: TIGR00725 1206780006807 thymidylate synthase; Provisional; Region: thyA; PRK00956 1206780006808 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1206780006809 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1206780006810 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1206780006811 E3 interaction surface; other site 1206780006812 lipoyl attachment site [posttranslational modification]; other site 1206780006813 e3 binding domain; Region: E3_binding; pfam02817 1206780006814 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1206780006815 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1206780006816 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1206780006817 alpha subunit interface [polypeptide binding]; other site 1206780006818 TPP binding site [chemical binding]; other site 1206780006819 heterodimer interface [polypeptide binding]; other site 1206780006820 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1206780006821 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1206780006822 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1206780006823 tetramer interface [polypeptide binding]; other site 1206780006824 TPP-binding site [chemical binding]; other site 1206780006825 heterodimer interface [polypeptide binding]; other site 1206780006826 phosphorylation loop region [posttranslational modification] 1206780006827 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1206780006828 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1206780006829 putative active site [active] 1206780006830 putative catalytic site [active] 1206780006831 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780006832 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780006833 active site 1206780006834 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1206780006835 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1206780006836 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1206780006837 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1206780006838 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1206780006839 carboxyltransferase (CT) interaction site; other site 1206780006840 biotinylation site [posttranslational modification]; other site 1206780006841 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1206780006842 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1206780006843 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1206780006844 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1206780006845 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1206780006846 AMP-binding domain protein; Validated; Region: PRK08315 1206780006847 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780006848 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1206780006849 acyl-activating enzyme (AAE) consensus motif; other site 1206780006850 acyl-activating enzyme (AAE) consensus motif; other site 1206780006851 putative AMP binding site [chemical binding]; other site 1206780006852 putative active site [active] 1206780006853 putative CoA binding site [chemical binding]; other site 1206780006854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780006855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780006856 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1206780006857 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1206780006858 classical (c) SDRs; Region: SDR_c; cd05233 1206780006859 NAD(P) binding site [chemical binding]; other site 1206780006860 active site 1206780006861 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1206780006862 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1206780006863 catalytic site [active] 1206780006864 putative active site [active] 1206780006865 putative substrate binding site [chemical binding]; other site 1206780006866 dimer interface [polypeptide binding]; other site 1206780006867 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1206780006868 MULE transposase domain; Region: MULE; pfam10551 1206780006869 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 1206780006870 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206780006871 non-specific DNA binding site [nucleotide binding]; other site 1206780006872 salt bridge; other site 1206780006873 sequence-specific DNA binding site [nucleotide binding]; other site 1206780006874 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1206780006875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1206780006876 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1206780006877 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1206780006878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1206780006879 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1206780006880 PE family; Region: PE; pfam00934 1206780006881 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1206780006882 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1206780006883 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1206780006884 catalytic triad [active] 1206780006885 hypothetical protein; Provisional; Region: PRK07907 1206780006886 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1206780006887 active site 1206780006888 metal binding site [ion binding]; metal-binding site 1206780006889 dimer interface [polypeptide binding]; other site 1206780006890 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1206780006891 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1206780006892 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1206780006893 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1206780006894 phosphate binding site [ion binding]; other site 1206780006895 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1206780006896 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1206780006897 putative active site [active] 1206780006898 putative catalytic site [active] 1206780006899 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1206780006900 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1206780006901 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1206780006902 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1206780006903 putative NAD(P) binding site [chemical binding]; other site 1206780006904 active site 1206780006905 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1206780006906 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1206780006907 active site 1206780006908 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1206780006909 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1206780006910 putative active site [active] 1206780006911 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1206780006912 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1206780006913 Restriction endonuclease; Region: Mrr_cat; pfam04471 1206780006914 ERCC4 domain; Region: ERCC4; pfam02732 1206780006915 Lsr2; Region: Lsr2; pfam11774 1206780006916 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1206780006917 putative active site [active] 1206780006918 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1206780006919 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1206780006920 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206780006921 catalytic residue [active] 1206780006922 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1206780006923 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1206780006924 putative RNA binding site [nucleotide binding]; other site 1206780006925 elongation factor P; Validated; Region: PRK00529 1206780006926 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1206780006927 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1206780006928 RNA binding site [nucleotide binding]; other site 1206780006929 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1206780006930 RNA binding site [nucleotide binding]; other site 1206780006931 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1206780006932 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1206780006933 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1206780006934 active site 1206780006935 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1206780006936 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1206780006937 trimer interface [polypeptide binding]; other site 1206780006938 active site 1206780006939 dimer interface [polypeptide binding]; other site 1206780006940 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1206780006941 active site 1206780006942 dimer interface [polypeptide binding]; other site 1206780006943 metal binding site [ion binding]; metal-binding site 1206780006944 shikimate kinase; Reviewed; Region: aroK; PRK00131 1206780006945 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1206780006946 ADP binding site [chemical binding]; other site 1206780006947 magnesium binding site [ion binding]; other site 1206780006948 putative shikimate binding site; other site 1206780006949 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1206780006950 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1206780006951 Tetramer interface [polypeptide binding]; other site 1206780006952 active site 1206780006953 FMN-binding site [chemical binding]; other site 1206780006954 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1206780006955 digalactosyldiacylglycerol synthase; Region: PLN02846 1206780006956 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1206780006957 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1206780006958 putative active site [active] 1206780006959 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1206780006960 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1206780006961 oligomeric interface; other site 1206780006962 putative active site [active] 1206780006963 homodimer interface [polypeptide binding]; other site 1206780006964 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 1206780006965 putative active site [active] 1206780006966 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1206780006967 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1206780006968 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1206780006969 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 1206780006970 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1206780006971 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1206780006972 NAD(P) binding site [chemical binding]; other site 1206780006973 shikimate binding site; other site 1206780006974 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1206780006975 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1206780006976 dimerization interface [polypeptide binding]; other site 1206780006977 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1206780006978 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1206780006979 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1206780006980 motif 1; other site 1206780006981 active site 1206780006982 motif 2; other site 1206780006983 motif 3; other site 1206780006984 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1206780006985 DHHA1 domain; Region: DHHA1; pfam02272 1206780006986 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1206780006987 recombination factor protein RarA; Reviewed; Region: PRK13342 1206780006988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780006989 Walker A motif; other site 1206780006990 ATP binding site [chemical binding]; other site 1206780006991 Walker B motif; other site 1206780006992 arginine finger; other site 1206780006993 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1206780006994 Predicted integral membrane protein [Function unknown]; Region: COG5473 1206780006995 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1206780006996 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1206780006997 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1206780006998 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1206780006999 Walker A/P-loop; other site 1206780007000 ATP binding site [chemical binding]; other site 1206780007001 Q-loop/lid; other site 1206780007002 ABC transporter signature motif; other site 1206780007003 Walker B; other site 1206780007004 D-loop; other site 1206780007005 H-loop/switch region; other site 1206780007006 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1206780007007 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1206780007008 ligand binding site [chemical binding]; other site 1206780007009 flexible hinge region; other site 1206780007010 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1206780007011 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1206780007012 ligand binding site [chemical binding]; other site 1206780007013 flexible hinge region; other site 1206780007014 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1206780007015 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1206780007016 active site 1206780007017 nucleophile elbow; other site 1206780007018 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1206780007019 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1206780007020 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1206780007021 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1206780007022 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1206780007023 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1206780007024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1206780007025 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1206780007026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1206780007027 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1206780007028 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1206780007029 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1206780007030 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1206780007031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 1206780007032 Predicted membrane protein [Function unknown]; Region: COG4129 1206780007033 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1206780007034 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1206780007035 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1206780007036 dimer interface [polypeptide binding]; other site 1206780007037 anticodon binding site; other site 1206780007038 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1206780007039 homodimer interface [polypeptide binding]; other site 1206780007040 motif 1; other site 1206780007041 active site 1206780007042 motif 2; other site 1206780007043 GAD domain; Region: GAD; pfam02938 1206780007044 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1206780007045 active site 1206780007046 motif 3; other site 1206780007047 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1206780007048 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1206780007049 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1206780007050 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1206780007051 putative hydrophobic ligand binding site [chemical binding]; other site 1206780007052 protein interface [polypeptide binding]; other site 1206780007053 gate; other site 1206780007054 Predicted metalloprotease [General function prediction only]; Region: COG2321 1206780007055 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1206780007056 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1206780007057 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1206780007058 active site 1206780007059 metal binding site [ion binding]; metal-binding site 1206780007060 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1206780007061 haloalkane dehalogenase; Provisional; Region: PRK03592 1206780007062 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1206780007063 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1206780007064 dimer interface [polypeptide binding]; other site 1206780007065 motif 1; other site 1206780007066 active site 1206780007067 motif 2; other site 1206780007068 motif 3; other site 1206780007069 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1206780007070 anticodon binding site; other site 1206780007071 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1206780007072 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1206780007073 active site 1206780007074 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1206780007075 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1206780007076 Zn2+ binding site [ion binding]; other site 1206780007077 Mg2+ binding site [ion binding]; other site 1206780007078 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1206780007079 synthetase active site [active] 1206780007080 NTP binding site [chemical binding]; other site 1206780007081 metal binding site [ion binding]; metal-binding site 1206780007082 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1206780007083 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1206780007084 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206780007085 active site 1206780007086 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1206780007087 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1206780007088 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1206780007089 Protein export membrane protein; Region: SecD_SecF; pfam02355 1206780007090 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1206780007091 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1206780007092 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1206780007093 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1206780007094 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1206780007095 inhibitor-cofactor binding pocket; inhibition site 1206780007096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780007097 catalytic residue [active] 1206780007098 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1206780007099 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780007100 acyl-activating enzyme (AAE) consensus motif; other site 1206780007101 AMP binding site [chemical binding]; other site 1206780007102 active site 1206780007103 CoA binding site [chemical binding]; other site 1206780007104 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1206780007105 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1206780007106 putative NAD(P) binding site [chemical binding]; other site 1206780007107 active site 1206780007108 putative substrate binding site [chemical binding]; other site 1206780007109 PE family; Region: PE; pfam00934 1206780007110 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1206780007111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780007112 Walker A motif; other site 1206780007113 ATP binding site [chemical binding]; other site 1206780007114 Walker B motif; other site 1206780007115 arginine finger; other site 1206780007116 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1206780007117 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1206780007118 RuvA N terminal domain; Region: RuvA_N; pfam01330 1206780007119 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1206780007120 active site 1206780007121 putative DNA-binding cleft [nucleotide binding]; other site 1206780007122 dimer interface [polypeptide binding]; other site 1206780007123 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1206780007124 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1206780007125 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1206780007126 putative active site [active] 1206780007127 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1206780007128 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1206780007129 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1206780007130 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1206780007131 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 1206780007132 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 1206780007133 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1206780007134 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1206780007135 hypothetical protein; Validated; Region: PRK00110 1206780007136 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1206780007137 predicted active site [active] 1206780007138 catalytic triad [active] 1206780007139 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1206780007140 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1206780007141 active site 1206780007142 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1206780007143 catalytic triad [active] 1206780007144 dimer interface [polypeptide binding]; other site 1206780007145 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1206780007146 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1206780007147 active site 1206780007148 multimer interface [polypeptide binding]; other site 1206780007149 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 1206780007150 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1206780007151 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1206780007152 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780007153 PPE family; Region: PPE; pfam00823 1206780007154 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780007155 PE-PPE domain; Region: PE-PPE; pfam08237 1206780007156 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1206780007157 nudix motif; other site 1206780007158 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206780007159 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1206780007160 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1206780007161 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1206780007162 putative acyl-acceptor binding pocket; other site 1206780007163 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1206780007164 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1206780007165 nucleotide binding site/active site [active] 1206780007166 HIT family signature motif; other site 1206780007167 catalytic residue [active] 1206780007168 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1206780007169 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1206780007170 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1206780007171 active site 1206780007172 dimer interface [polypeptide binding]; other site 1206780007173 motif 1; other site 1206780007174 motif 2; other site 1206780007175 motif 3; other site 1206780007176 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1206780007177 anticodon binding site; other site 1206780007178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 1206780007179 Helix-turn-helix domain; Region: HTH_20; pfam12840 1206780007180 Predicted transcriptional regulator [Transcription]; Region: COG2345 1206780007181 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1206780007182 Predicted transcriptional regulator [Transcription]; Region: COG2345 1206780007183 Helix-turn-helix domain; Region: HTH_20; pfam12840 1206780007184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780007185 S-adenosylmethionine binding site [chemical binding]; other site 1206780007186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206780007187 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206780007188 Ligand Binding Site [chemical binding]; other site 1206780007189 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206780007190 Ligand Binding Site [chemical binding]; other site 1206780007191 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206780007192 Ligand Binding Site [chemical binding]; other site 1206780007193 Universal stress protein family; Region: Usp; pfam00582 1206780007194 Ligand Binding Site [chemical binding]; other site 1206780007195 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1206780007196 active site 1206780007197 Peptidase family M50; Region: Peptidase_M50; pfam02163 1206780007198 putative substrate binding region [chemical binding]; other site 1206780007199 FOG: CBS domain [General function prediction only]; Region: COG0517 1206780007200 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1206780007201 FOG: CBS domain [General function prediction only]; Region: COG0517 1206780007202 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1206780007203 peptide chain release factor 1; Provisional; Region: PRK04011 1206780007204 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 1206780007205 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 1206780007206 hypothetical protein; Reviewed; Region: PRK09588 1206780007207 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1206780007208 Hemerythrin-like domain; Region: Hr-like; cd12108 1206780007209 Fe binding site [ion binding]; other site 1206780007210 PE family; Region: PE; pfam00934 1206780007211 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 1206780007212 P-loop motif; other site 1206780007213 ATP binding site [chemical binding]; other site 1206780007214 Chloramphenicol (Cm) binding site [chemical binding]; other site 1206780007215 catalytic residue [active] 1206780007216 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1206780007217 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1206780007218 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1206780007219 anti sigma factor interaction site; other site 1206780007220 regulatory phosphorylation site [posttranslational modification]; other site 1206780007221 hypothetical protein; Provisional; Region: PRK02237 1206780007222 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206780007223 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1206780007224 putative DNA binding site [nucleotide binding]; other site 1206780007225 putative Zn2+ binding site [ion binding]; other site 1206780007226 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1206780007227 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1206780007228 putative metal binding site [ion binding]; other site 1206780007229 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206780007230 dimerization interface [polypeptide binding]; other site 1206780007231 putative DNA binding site [nucleotide binding]; other site 1206780007232 putative Zn2+ binding site [ion binding]; other site 1206780007233 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1206780007234 arsenical-resistance protein; Region: acr3; TIGR00832 1206780007235 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1206780007236 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1206780007237 active site 1206780007238 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 1206780007239 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1206780007240 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1206780007241 MULE transposase domain; Region: MULE; pfam10551 1206780007242 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1206780007243 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1206780007244 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206780007245 Coenzyme A binding pocket [chemical binding]; other site 1206780007246 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1206780007247 hypothetical protein; Provisional; Region: PRK14059 1206780007248 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1206780007249 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206780007250 TAP-like protein; Region: Abhydrolase_4; pfam08386 1206780007251 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1206780007252 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1206780007253 SelR domain; Region: SelR; pfam01641 1206780007254 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1206780007255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780007256 S-adenosylmethionine binding site [chemical binding]; other site 1206780007257 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1206780007258 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1206780007259 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1206780007260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206780007261 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1206780007262 substrate binding site [chemical binding]; other site 1206780007263 active site 1206780007264 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780007265 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1206780007266 substrate binding site [chemical binding]; other site 1206780007267 oxyanion hole (OAH) forming residues; other site 1206780007268 trimer interface [polypeptide binding]; other site 1206780007269 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1206780007270 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1206780007271 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1206780007272 catalytic site [active] 1206780007273 putative active site [active] 1206780007274 putative substrate binding site [chemical binding]; other site 1206780007275 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1206780007276 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1206780007277 TPP-binding site; other site 1206780007278 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1206780007279 PYR/PP interface [polypeptide binding]; other site 1206780007280 dimer interface [polypeptide binding]; other site 1206780007281 TPP binding site [chemical binding]; other site 1206780007282 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1206780007283 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1206780007284 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1206780007285 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1206780007286 transmembrane helices; other site 1206780007287 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1206780007288 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1206780007289 transmembrane helices; other site 1206780007290 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1206780007291 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1206780007292 Walker A/P-loop; other site 1206780007293 ATP binding site [chemical binding]; other site 1206780007294 Q-loop/lid; other site 1206780007295 ABC transporter signature motif; other site 1206780007296 Walker B; other site 1206780007297 D-loop; other site 1206780007298 H-loop/switch region; other site 1206780007299 TRAM domain; Region: TRAM; cl01282 1206780007300 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1206780007301 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1206780007302 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1206780007303 TrkA-N domain; Region: TrkA_N; pfam02254 1206780007304 TrkA-C domain; Region: TrkA_C; pfam02080 1206780007305 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1206780007306 TrkA-N domain; Region: TrkA_N; pfam02254 1206780007307 TrkA-C domain; Region: TrkA_C; pfam02080 1206780007308 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1206780007309 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1206780007310 generic binding surface II; other site 1206780007311 ssDNA binding site; other site 1206780007312 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1206780007313 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1206780007314 trimer interface [polypeptide binding]; other site 1206780007315 active site 1206780007316 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1206780007317 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1206780007318 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1206780007319 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1206780007320 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1206780007321 active site 1206780007322 dimerization interface [polypeptide binding]; other site 1206780007323 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1206780007324 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1206780007325 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1206780007326 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206780007327 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1206780007328 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206780007329 DNA binding residues [nucleotide binding] 1206780007330 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1206780007331 homotrimer interaction site [polypeptide binding]; other site 1206780007332 putative active site [active] 1206780007333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 1206780007334 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1206780007335 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1206780007336 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1206780007337 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1206780007338 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1206780007339 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206780007340 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1206780007341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206780007342 DNA binding residues [nucleotide binding] 1206780007343 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1206780007344 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1206780007345 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1206780007346 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1206780007347 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1206780007348 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1206780007349 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206780007350 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206780007351 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1206780007352 PAC2 family; Region: PAC2; pfam09754 1206780007353 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206780007354 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1206780007355 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1206780007356 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1206780007357 heme-binding site [chemical binding]; other site 1206780007358 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1206780007359 ATP cone domain; Region: ATP-cone; pfam03477 1206780007360 LysM domain; Region: LysM; pfam01476 1206780007361 LexA repressor; Validated; Region: PRK00215 1206780007362 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1206780007363 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1206780007364 Catalytic site [active] 1206780007365 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1206780007366 LGFP repeat; Region: LGFP; pfam08310 1206780007367 LGFP repeat; Region: LGFP; pfam08310 1206780007368 LGFP repeat; Region: LGFP; pfam08310 1206780007369 LGFP repeat; Region: LGFP; pfam08310 1206780007370 LGFP repeat; Region: LGFP; pfam08310 1206780007371 Integral membrane protein TerC family; Region: TerC; cl10468 1206780007372 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780007373 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780007374 active site 1206780007375 GTPases [General function prediction only]; Region: HflX; COG2262 1206780007376 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1206780007377 HflX GTPase family; Region: HflX; cd01878 1206780007378 G1 box; other site 1206780007379 GTP/Mg2+ binding site [chemical binding]; other site 1206780007380 Switch I region; other site 1206780007381 G2 box; other site 1206780007382 G3 box; other site 1206780007383 Switch II region; other site 1206780007384 G4 box; other site 1206780007385 G5 box; other site 1206780007386 diaminopimelate epimerase; Region: DapF; TIGR00652 1206780007387 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1206780007388 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1206780007389 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1206780007390 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1206780007391 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1206780007392 active site 1206780007393 metal binding site [ion binding]; metal-binding site 1206780007394 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1206780007395 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1206780007396 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1206780007397 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1206780007398 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1206780007399 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206780007400 FeS/SAM binding site; other site 1206780007401 TRAM domain; Region: TRAM; cl01282 1206780007402 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206780007403 FeS/SAM binding site; other site 1206780007404 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 1206780007405 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 1206780007406 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1206780007407 hexamer interface [polypeptide binding]; other site 1206780007408 Walker A motif; other site 1206780007409 ATP binding site [chemical binding]; other site 1206780007410 Walker B motif; other site 1206780007411 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1206780007412 protein-splicing catalytic site; other site 1206780007413 thioester formation/cholesterol transfer; other site 1206780007414 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1206780007415 recA bacterial DNA recombination protein; Region: RecA; cl17211 1206780007416 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1206780007417 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1206780007418 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1206780007419 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1206780007420 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 1206780007421 PE family; Region: PE; pfam00934 1206780007422 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1206780007423 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1206780007424 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1206780007425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206780007426 non-specific DNA binding site [nucleotide binding]; other site 1206780007427 salt bridge; other site 1206780007428 sequence-specific DNA binding site [nucleotide binding]; other site 1206780007429 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1206780007430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206780007431 Coenzyme A binding pocket [chemical binding]; other site 1206780007432 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1206780007433 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206780007434 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1206780007435 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1206780007436 classical (c) SDRs; Region: SDR_c; cd05233 1206780007437 NAD(P) binding site [chemical binding]; other site 1206780007438 active site 1206780007439 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1206780007440 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1206780007441 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1206780007442 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1206780007443 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1206780007444 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1206780007445 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1206780007446 dimer interface [polypeptide binding]; other site 1206780007447 active site 1206780007448 catalytic residue [active] 1206780007449 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1206780007450 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1206780007451 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1206780007452 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1206780007453 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1206780007454 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1206780007455 putative active site [active] 1206780007456 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1206780007457 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1206780007458 putative active site [active] 1206780007459 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1206780007460 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1206780007461 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1206780007462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1206780007463 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1206780007464 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1206780007465 folate binding site [chemical binding]; other site 1206780007466 NADP+ binding site [chemical binding]; other site 1206780007467 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1206780007468 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1206780007469 dimerization interface [polypeptide binding]; other site 1206780007470 active site 1206780007471 Dienelactone hydrolase family; Region: DLH; pfam01738 1206780007472 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1206780007473 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1206780007474 classical (c) SDRs; Region: SDR_c; cd05233 1206780007475 NAD(P) binding site [chemical binding]; other site 1206780007476 active site 1206780007477 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780007478 PPE family; Region: PPE; pfam00823 1206780007479 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780007480 PE family; Region: PE; pfam00934 1206780007481 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780007482 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780007483 PPE family; Region: PPE; pfam00823 1206780007484 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1206780007485 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1206780007486 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1206780007487 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1206780007488 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1206780007489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206780007490 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1206780007491 Coenzyme A binding pocket [chemical binding]; other site 1206780007492 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1206780007493 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1206780007494 FMN-binding pocket [chemical binding]; other site 1206780007495 flavin binding motif; other site 1206780007496 phosphate binding motif [ion binding]; other site 1206780007497 beta-alpha-beta structure motif; other site 1206780007498 NAD binding pocket [chemical binding]; other site 1206780007499 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1206780007500 catalytic loop [active] 1206780007501 iron binding site [ion binding]; other site 1206780007502 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1206780007503 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1206780007504 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1206780007505 hydrophobic ligand binding site; other site 1206780007506 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1206780007507 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206780007508 putative DNA binding site [nucleotide binding]; other site 1206780007509 putative Zn2+ binding site [ion binding]; other site 1206780007510 AsnC family; Region: AsnC_trans_reg; pfam01037 1206780007511 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1206780007512 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1206780007513 NAD binding site [chemical binding]; other site 1206780007514 Nitronate monooxygenase; Region: NMO; pfam03060 1206780007515 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1206780007516 FMN binding site [chemical binding]; other site 1206780007517 substrate binding site [chemical binding]; other site 1206780007518 putative catalytic residue [active] 1206780007519 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1206780007520 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1206780007521 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1206780007522 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1206780007523 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1206780007524 oligomer interface [polypeptide binding]; other site 1206780007525 RNA binding site [nucleotide binding]; other site 1206780007526 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1206780007527 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1206780007528 RNase E interface [polypeptide binding]; other site 1206780007529 trimer interface [polypeptide binding]; other site 1206780007530 active site 1206780007531 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1206780007532 putative nucleic acid binding region [nucleotide binding]; other site 1206780007533 G-X-X-G motif; other site 1206780007534 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1206780007535 RNA binding site [nucleotide binding]; other site 1206780007536 domain interface; other site 1206780007537 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1206780007538 16S/18S rRNA binding site [nucleotide binding]; other site 1206780007539 S13e-L30e interaction site [polypeptide binding]; other site 1206780007540 25S rRNA binding site [nucleotide binding]; other site 1206780007541 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1206780007542 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1206780007543 active site 1206780007544 Riboflavin kinase; Region: Flavokinase; pfam01687 1206780007545 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1206780007546 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1206780007547 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1206780007548 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206780007549 putative DNA binding site [nucleotide binding]; other site 1206780007550 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1206780007551 FeoA domain; Region: FeoA; pfam04023 1206780007552 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780007553 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780007554 active site 1206780007555 lipid-transfer protein; Provisional; Region: PRK08256 1206780007556 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1206780007557 active site 1206780007558 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1206780007559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1206780007560 Probable transposase; Region: OrfB_IS605; pfam01385 1206780007561 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1206780007562 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1206780007563 catalytic residues [active] 1206780007564 catalytic nucleophile [active] 1206780007565 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1206780007566 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1206780007567 RNA binding site [nucleotide binding]; other site 1206780007568 active site 1206780007569 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1206780007570 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1206780007571 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1206780007572 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1206780007573 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1206780007574 active site 1206780007575 metal binding site [ion binding]; metal-binding site 1206780007576 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1206780007577 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1206780007578 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1206780007579 Predicted acyl esterases [General function prediction only]; Region: COG2936 1206780007580 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1206780007581 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1206780007582 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1206780007583 Uncharacterized conserved protein [Function unknown]; Region: COG5586 1206780007584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1206780007585 Integrase core domain; Region: rve; pfam00665 1206780007586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1206780007587 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1206780007588 Helix-turn-helix domain; Region: HTH_28; pfam13518 1206780007589 Winged helix-turn helix; Region: HTH_29; pfam13551 1206780007590 Integrase core domain; Region: rve; pfam00665 1206780007591 Integrase core domain; Region: rve_3; pfam13683 1206780007592 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1206780007593 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1206780007594 putative transposase OrfB; Reviewed; Region: PHA02517 1206780007595 HTH-like domain; Region: HTH_21; pfam13276 1206780007596 Integrase core domain; Region: rve; pfam00665 1206780007597 Integrase core domain; Region: rve_3; pfam13683 1206780007598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1206780007599 Transposase; Region: HTH_Tnp_1; cl17663 1206780007600 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1206780007601 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 1206780007602 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 1206780007603 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 1206780007604 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 1206780007605 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 1206780007606 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 1206780007607 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 1206780007608 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 1206780007609 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1206780007610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 1206780007611 Uncharacterized conserved protein [Function unknown]; Region: COG2253 1206780007612 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 1206780007613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 1206780007614 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1206780007615 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1206780007616 putative active site [active] 1206780007617 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1206780007618 enoyl-CoA hydratase; Provisional; Region: PRK06190 1206780007619 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780007620 substrate binding site [chemical binding]; other site 1206780007621 oxyanion hole (OAH) forming residues; other site 1206780007622 trimer interface [polypeptide binding]; other site 1206780007623 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1206780007624 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1206780007625 Walker A/P-loop; other site 1206780007626 ATP binding site [chemical binding]; other site 1206780007627 Q-loop/lid; other site 1206780007628 ABC transporter signature motif; other site 1206780007629 Walker B; other site 1206780007630 D-loop; other site 1206780007631 H-loop/switch region; other site 1206780007632 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1206780007633 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1206780007634 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1206780007635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780007636 dimer interface [polypeptide binding]; other site 1206780007637 conserved gate region; other site 1206780007638 putative PBP binding loops; other site 1206780007639 ABC-ATPase subunit interface; other site 1206780007640 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1206780007641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780007642 dimer interface [polypeptide binding]; other site 1206780007643 conserved gate region; other site 1206780007644 putative PBP binding loops; other site 1206780007645 ABC-ATPase subunit interface; other site 1206780007646 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1206780007647 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1206780007648 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1206780007649 DHH family; Region: DHH; pfam01368 1206780007650 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1206780007651 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1206780007652 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1206780007653 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1206780007654 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1206780007655 G1 box; other site 1206780007656 putative GEF interaction site [polypeptide binding]; other site 1206780007657 GTP/Mg2+ binding site [chemical binding]; other site 1206780007658 Switch I region; other site 1206780007659 G2 box; other site 1206780007660 G3 box; other site 1206780007661 Switch II region; other site 1206780007662 G4 box; other site 1206780007663 G5 box; other site 1206780007664 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1206780007665 Translation-initiation factor 2; Region: IF-2; pfam11987 1206780007666 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1206780007667 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 1206780007668 putative RNA binding cleft [nucleotide binding]; other site 1206780007669 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1206780007670 NusA N-terminal domain; Region: NusA_N; pfam08529 1206780007671 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1206780007672 RNA binding site [nucleotide binding]; other site 1206780007673 homodimer interface [polypeptide binding]; other site 1206780007674 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1206780007675 G-X-X-G motif; other site 1206780007676 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1206780007677 G-X-X-G motif; other site 1206780007678 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1206780007679 Sm and related proteins; Region: Sm_like; cl00259 1206780007680 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1206780007681 putative oligomer interface [polypeptide binding]; other site 1206780007682 putative RNA binding site [nucleotide binding]; other site 1206780007683 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 1206780007684 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1206780007685 dinuclear metal binding motif [ion binding]; other site 1206780007686 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1206780007687 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1206780007688 dimer interface [polypeptide binding]; other site 1206780007689 motif 1; other site 1206780007690 active site 1206780007691 motif 2; other site 1206780007692 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1206780007693 putative deacylase active site [active] 1206780007694 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1206780007695 active site 1206780007696 motif 3; other site 1206780007697 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1206780007698 anticodon binding site; other site 1206780007699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780007700 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1206780007701 putative substrate translocation pore; other site 1206780007702 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1206780007703 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1206780007704 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1206780007705 homodimer interface [polypeptide binding]; other site 1206780007706 active site 1206780007707 SAM binding site [chemical binding]; other site 1206780007708 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1206780007709 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1206780007710 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1206780007711 catalytic triad [active] 1206780007712 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1206780007713 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1206780007714 homodimer interface [polypeptide binding]; other site 1206780007715 Walker A motif; other site 1206780007716 ATP binding site [chemical binding]; other site 1206780007717 hydroxycobalamin binding site [chemical binding]; other site 1206780007718 Walker B motif; other site 1206780007719 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1206780007720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780007721 Walker A motif; other site 1206780007722 ATP binding site [chemical binding]; other site 1206780007723 Walker B motif; other site 1206780007724 arginine finger; other site 1206780007725 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1206780007726 metal ion-dependent adhesion site (MIDAS); other site 1206780007727 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 1206780007728 malate:quinone oxidoreductase; Validated; Region: PRK05257 1206780007729 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1206780007730 PE family; Region: PE; pfam00934 1206780007731 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1206780007732 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1206780007733 mycothione reductase; Reviewed; Region: PRK07846 1206780007734 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206780007735 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206780007736 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1206780007737 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1206780007738 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1206780007739 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1206780007740 short chain dehydrogenase; Provisional; Region: PRK06057 1206780007741 classical (c) SDRs; Region: SDR_c; cd05233 1206780007742 NAD(P) binding site [chemical binding]; other site 1206780007743 active site 1206780007744 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1206780007745 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1206780007746 NAD(P) binding site [chemical binding]; other site 1206780007747 catalytic residues [active] 1206780007748 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1206780007749 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1206780007750 catalytic triad [active] 1206780007751 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1206780007752 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1206780007753 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1206780007754 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1206780007755 active site 1206780007756 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1206780007757 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1206780007758 putative active site [active] 1206780007759 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1206780007760 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1206780007761 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1206780007762 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1206780007763 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1206780007764 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1206780007765 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1206780007766 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1206780007767 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1206780007768 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1206780007769 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1206780007770 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1206780007771 active site 1206780007772 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1206780007773 protein binding site [polypeptide binding]; other site 1206780007774 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1206780007775 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1206780007776 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1206780007777 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1206780007778 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1206780007779 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1206780007780 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1206780007781 Fasciclin domain; Region: Fasciclin; pfam02469 1206780007782 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1206780007783 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1206780007784 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1206780007785 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1206780007786 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1206780007787 catalytic residues [active] 1206780007788 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1206780007789 Fasciclin domain; Region: Fasciclin; pfam02469 1206780007790 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1206780007791 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1206780007792 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1206780007793 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1206780007794 catalytic residues [active] 1206780007795 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1206780007796 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206780007797 FeS/SAM binding site; other site 1206780007798 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1206780007799 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1206780007800 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1206780007801 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1206780007802 hinge region; other site 1206780007803 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1206780007804 putative nucleotide binding site [chemical binding]; other site 1206780007805 uridine monophosphate binding site [chemical binding]; other site 1206780007806 homohexameric interface [polypeptide binding]; other site 1206780007807 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206780007808 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206780007809 DNA binding site [nucleotide binding] 1206780007810 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1206780007811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1206780007812 Probable transposase; Region: OrfB_IS605; pfam01385 1206780007813 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1206780007814 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1206780007815 catalytic residues [active] 1206780007816 catalytic nucleophile [active] 1206780007817 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1206780007818 MarR family; Region: MarR; pfam01047 1206780007819 amidase; Provisional; Region: PRK07869 1206780007820 Amidase; Region: Amidase; pfam01425 1206780007821 elongation factor Ts; Provisional; Region: tsf; PRK09377 1206780007822 UBA/TS-N domain; Region: UBA; pfam00627 1206780007823 Elongation factor TS; Region: EF_TS; pfam00889 1206780007824 Elongation factor TS; Region: EF_TS; pfam00889 1206780007825 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1206780007826 rRNA interaction site [nucleotide binding]; other site 1206780007827 S8 interaction site; other site 1206780007828 putative laminin-1 binding site; other site 1206780007829 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1206780007830 Peptidase family M23; Region: Peptidase_M23; pfam01551 1206780007831 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780007832 PPE family; Region: PPE; pfam00823 1206780007833 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780007834 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1206780007835 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1206780007836 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1206780007837 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1206780007838 active site 1206780007839 DNA binding site [nucleotide binding] 1206780007840 Int/Topo IB signature motif; other site 1206780007841 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1206780007842 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1206780007843 FAD binding pocket [chemical binding]; other site 1206780007844 FAD binding motif [chemical binding]; other site 1206780007845 phosphate binding motif [ion binding]; other site 1206780007846 NAD binding pocket [chemical binding]; other site 1206780007847 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1206780007848 DNA protecting protein DprA; Region: dprA; TIGR00732 1206780007849 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1206780007850 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1206780007851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780007852 Walker A motif; other site 1206780007853 ATP binding site [chemical binding]; other site 1206780007854 Walker B motif; other site 1206780007855 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1206780007856 hypothetical protein; Reviewed; Region: PRK12497 1206780007857 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1206780007858 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1206780007859 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1206780007860 putative molybdopterin cofactor binding site [chemical binding]; other site 1206780007861 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1206780007862 putative molybdopterin cofactor binding site; other site 1206780007863 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1206780007864 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1206780007865 RNA/DNA hybrid binding site [nucleotide binding]; other site 1206780007866 active site 1206780007867 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1206780007868 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1206780007869 Catalytic site [active] 1206780007870 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1206780007871 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1206780007872 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1206780007873 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1206780007874 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1206780007875 RimM N-terminal domain; Region: RimM; pfam01782 1206780007876 hypothetical protein; Provisional; Region: PRK02821 1206780007877 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1206780007878 G-X-X-G motif; other site 1206780007879 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1206780007880 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1206780007881 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1206780007882 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1206780007883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780007884 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780007885 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1206780007886 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1206780007887 active site 1206780007888 putative substrate binding pocket [chemical binding]; other site 1206780007889 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1206780007890 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1206780007891 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1206780007892 active site 1206780007893 ATP binding site [chemical binding]; other site 1206780007894 substrate binding site [chemical binding]; other site 1206780007895 activation loop (A-loop); other site 1206780007896 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1206780007897 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1206780007898 active site 1206780007899 signal recognition particle protein; Provisional; Region: PRK10867 1206780007900 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1206780007901 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1206780007902 P loop; other site 1206780007903 GTP binding site [chemical binding]; other site 1206780007904 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1206780007905 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1206780007906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1206780007907 ATP binding site [chemical binding]; other site 1206780007908 putative Mg++ binding site [ion binding]; other site 1206780007909 PII uridylyl-transferase; Provisional; Region: PRK03381 1206780007910 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1206780007911 metal binding triad; other site 1206780007912 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1206780007913 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1206780007914 Zn2+ binding site [ion binding]; other site 1206780007915 Mg2+ binding site [ion binding]; other site 1206780007916 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1206780007917 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1206780007918 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1206780007919 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1206780007920 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1206780007921 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1206780007922 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1206780007923 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1206780007924 Walker A/P-loop; other site 1206780007925 ATP binding site [chemical binding]; other site 1206780007926 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1206780007927 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1206780007928 ABC transporter signature motif; other site 1206780007929 Walker B; other site 1206780007930 D-loop; other site 1206780007931 H-loop/switch region; other site 1206780007932 acylphosphatase; Provisional; Region: PRK14422 1206780007933 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1206780007934 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1206780007935 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1206780007936 DNA binding site [nucleotide binding] 1206780007937 catalytic residue [active] 1206780007938 H2TH interface [polypeptide binding]; other site 1206780007939 putative catalytic residues [active] 1206780007940 turnover-facilitating residue; other site 1206780007941 intercalation triad [nucleotide binding]; other site 1206780007942 8OG recognition residue [nucleotide binding]; other site 1206780007943 putative reading head residues; other site 1206780007944 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1206780007945 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1206780007946 ribonuclease III; Reviewed; Region: rnc; PRK00102 1206780007947 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1206780007948 dimerization interface [polypeptide binding]; other site 1206780007949 active site 1206780007950 metal binding site [ion binding]; metal-binding site 1206780007951 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1206780007952 dsRNA binding site [nucleotide binding]; other site 1206780007953 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1206780007954 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1206780007955 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1206780007956 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1206780007957 acyl-CoA synthetase; Validated; Region: PRK05850 1206780007958 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1206780007959 acyl-activating enzyme (AAE) consensus motif; other site 1206780007960 active site 1206780007961 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1206780007962 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1206780007963 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780007964 active site 1206780007965 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1206780007966 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1206780007967 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1206780007968 NADP binding site [chemical binding]; other site 1206780007969 KR domain; Region: KR; pfam08659 1206780007970 active site 1206780007971 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780007972 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780007973 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1206780007974 active site 1206780007975 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1206780007976 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1206780007977 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1206780007978 KR domain; Region: KR; pfam08659 1206780007979 NADP binding site [chemical binding]; other site 1206780007980 active site 1206780007981 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780007982 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1206780007983 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780007984 active site 1206780007985 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1206780007986 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1206780007987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780007988 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1206780007989 Enoylreductase; Region: PKS_ER; smart00829 1206780007990 NAD(P) binding site [chemical binding]; other site 1206780007991 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1206780007992 KR domain; Region: KR; pfam08659 1206780007993 putative NADP binding site [chemical binding]; other site 1206780007994 active site 1206780007995 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780007996 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1206780007997 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780007998 active site 1206780007999 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1206780008000 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1206780008001 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1206780008002 KR domain; Region: KR; pfam08659 1206780008003 putative NADP binding site [chemical binding]; other site 1206780008004 active site 1206780008005 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780008006 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1206780008007 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780008008 active site 1206780008009 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1206780008010 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1206780008011 Condensation domain; Region: Condensation; pfam00668 1206780008012 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1206780008013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206780008014 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1206780008015 Walker A/P-loop; other site 1206780008016 ATP binding site [chemical binding]; other site 1206780008017 Q-loop/lid; other site 1206780008018 ABC transporter signature motif; other site 1206780008019 Walker B; other site 1206780008020 D-loop; other site 1206780008021 H-loop/switch region; other site 1206780008022 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1206780008023 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1206780008024 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1206780008025 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1206780008026 acyltransferase PapA5; Provisional; Region: PRK09294 1206780008027 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1206780008028 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780008029 active site 1206780008030 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1206780008031 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1206780008032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780008033 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1206780008034 Enoylreductase; Region: PKS_ER; smart00829 1206780008035 NAD(P) binding site [chemical binding]; other site 1206780008036 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1206780008037 KR domain; Region: KR; pfam08659 1206780008038 putative NADP binding site [chemical binding]; other site 1206780008039 active site 1206780008040 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780008041 acyl-CoA synthetase; Validated; Region: PRK05850 1206780008042 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1206780008043 acyl-activating enzyme (AAE) consensus motif; other site 1206780008044 active site 1206780008045 MMPL family; Region: MMPL; pfam03176 1206780008046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1206780008047 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1206780008048 Integrase core domain; Region: rve; pfam00665 1206780008049 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1206780008050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780008051 ATP binding site [chemical binding]; other site 1206780008052 Walker A motif; other site 1206780008053 Walker B motif; other site 1206780008054 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1206780008055 Erythronolide synthase docking; Region: Docking; pfam08990 1206780008056 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1206780008057 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780008058 active site 1206780008059 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1206780008060 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1206780008061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780008062 Enoylreductase; Region: PKS_ER; smart00829 1206780008063 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1206780008064 NAD(P) binding site [chemical binding]; other site 1206780008065 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1206780008066 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1206780008067 putative NADP binding site [chemical binding]; other site 1206780008068 active site 1206780008069 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780008070 acyl-CoA synthetase; Validated; Region: PRK06060 1206780008071 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 1206780008072 dimer interface [polypeptide binding]; other site 1206780008073 acyl-activating enzyme (AAE) consensus motif; other site 1206780008074 putative active site [active] 1206780008075 putative AMP binding site [chemical binding]; other site 1206780008076 putative CoA binding site [chemical binding]; other site 1206780008077 chemical substrate binding site [chemical binding]; other site 1206780008078 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780008079 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 1206780008080 acyl-CoA synthetase; Validated; Region: PRK05850 1206780008081 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1206780008082 acyl-activating enzyme (AAE) consensus motif; other site 1206780008083 active site 1206780008084 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1206780008085 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1206780008086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780008087 S-adenosylmethionine binding site [chemical binding]; other site 1206780008088 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1206780008089 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206780008090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780008091 S-adenosylmethionine binding site [chemical binding]; other site 1206780008092 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1206780008093 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1206780008094 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1206780008095 metal-binding site 1206780008096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780008097 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1206780008098 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1206780008099 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 1206780008100 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1206780008101 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1206780008102 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1206780008103 active site 1206780008104 TDP-binding site; other site 1206780008105 acceptor substrate-binding pocket; other site 1206780008106 Predicted permease; Region: DUF318; pfam03773 1206780008107 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 1206780008108 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1206780008109 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1206780008110 putative active site [active] 1206780008111 putative substrate binding site [chemical binding]; other site 1206780008112 putative cosubstrate binding site; other site 1206780008113 catalytic site [active] 1206780008114 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1206780008115 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1206780008116 active site 1206780008117 (T/H)XGH motif; other site 1206780008118 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1206780008119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780008120 S-adenosylmethionine binding site [chemical binding]; other site 1206780008121 pyruvate carboxylase; Reviewed; Region: PRK12999 1206780008122 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1206780008123 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1206780008124 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1206780008125 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1206780008126 active site 1206780008127 catalytic residues [active] 1206780008128 metal binding site [ion binding]; metal-binding site 1206780008129 homodimer binding site [polypeptide binding]; other site 1206780008130 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1206780008131 carboxyltransferase (CT) interaction site; other site 1206780008132 biotinylation site [posttranslational modification]; other site 1206780008133 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1206780008134 putative active site [active] 1206780008135 redox center [active] 1206780008136 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1206780008137 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1206780008138 catalytic residues [active] 1206780008139 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1206780008140 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1206780008141 substrate binding pocket [chemical binding]; other site 1206780008142 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1206780008143 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1206780008144 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1206780008145 active site 1206780008146 catalytic tetrad [active] 1206780008147 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1206780008148 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1206780008149 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1206780008150 generic binding surface II; other site 1206780008151 ssDNA binding site; other site 1206780008152 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206780008153 ATP binding site [chemical binding]; other site 1206780008154 putative Mg++ binding site [ion binding]; other site 1206780008155 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206780008156 nucleotide binding region [chemical binding]; other site 1206780008157 ATP-binding site [chemical binding]; other site 1206780008158 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1206780008159 DAK2 domain; Region: Dak2; cl03685 1206780008160 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1206780008161 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1206780008162 ligand binding site [chemical binding]; other site 1206780008163 active site 1206780008164 UGI interface [polypeptide binding]; other site 1206780008165 catalytic site [active] 1206780008166 thiamine monophosphate kinase; Provisional; Region: PRK05731 1206780008167 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1206780008168 ATP binding site [chemical binding]; other site 1206780008169 dimerization interface [polypeptide binding]; other site 1206780008170 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1206780008171 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1206780008172 Probable transposase; Region: OrfB_IS605; pfam01385 1206780008173 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1206780008174 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1206780008175 catalytic residues [active] 1206780008176 catalytic nucleophile [active] 1206780008177 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1206780008178 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1206780008179 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1206780008180 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1206780008181 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1206780008182 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1206780008183 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1206780008184 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 1206780008185 polyphosphate kinase; Provisional; Region: PRK05443 1206780008186 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1206780008187 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1206780008188 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1206780008189 putative domain interface [polypeptide binding]; other site 1206780008190 putative active site [active] 1206780008191 catalytic site [active] 1206780008192 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1206780008193 putative domain interface [polypeptide binding]; other site 1206780008194 putative active site [active] 1206780008195 catalytic site [active] 1206780008196 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1206780008197 active site 1206780008198 Ap6A binding site [chemical binding]; other site 1206780008199 nudix motif; other site 1206780008200 metal binding site [ion binding]; metal-binding site 1206780008201 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206780008202 catalytic core [active] 1206780008203 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1206780008204 IHF - DNA interface [nucleotide binding]; other site 1206780008205 IHF dimer interface [polypeptide binding]; other site 1206780008206 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1206780008207 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1206780008208 substrate binding site [chemical binding]; other site 1206780008209 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1206780008210 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1206780008211 substrate binding site [chemical binding]; other site 1206780008212 ligand binding site [chemical binding]; other site 1206780008213 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1206780008214 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1206780008215 Bacterial transcriptional regulator; Region: IclR; pfam01614 1206780008216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780008217 S-adenosylmethionine binding site [chemical binding]; other site 1206780008218 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1206780008219 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1206780008220 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1206780008221 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1206780008222 active site 1206780008223 HIGH motif; other site 1206780008224 nucleotide binding site [chemical binding]; other site 1206780008225 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1206780008226 active site 1206780008227 KMSKS motif; other site 1206780008228 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1206780008229 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1206780008230 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1206780008231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780008232 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1206780008233 putative substrate translocation pore; other site 1206780008234 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1206780008235 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1206780008236 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1206780008237 ligand binding site [chemical binding]; other site 1206780008238 NAD binding site [chemical binding]; other site 1206780008239 dimerization interface [polypeptide binding]; other site 1206780008240 catalytic site [active] 1206780008241 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1206780008242 putative L-serine binding site [chemical binding]; other site 1206780008243 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1206780008244 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1206780008245 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1206780008246 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1206780008247 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1206780008248 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1206780008249 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1206780008250 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1206780008251 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1206780008252 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1206780008253 putative valine binding site [chemical binding]; other site 1206780008254 dimer interface [polypeptide binding]; other site 1206780008255 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1206780008256 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1206780008257 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1206780008258 PYR/PP interface [polypeptide binding]; other site 1206780008259 dimer interface [polypeptide binding]; other site 1206780008260 TPP binding site [chemical binding]; other site 1206780008261 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1206780008262 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1206780008263 TPP-binding site [chemical binding]; other site 1206780008264 dimer interface [polypeptide binding]; other site 1206780008265 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1206780008266 Predicted membrane protein [Function unknown]; Region: COG2259 1206780008267 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1206780008268 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1206780008269 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1206780008270 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1206780008271 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1206780008272 GatB domain; Region: GatB_Yqey; smart00845 1206780008273 6-phosphofructokinase; Provisional; Region: PRK03202 1206780008274 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1206780008275 active site 1206780008276 ADP/pyrophosphate binding site [chemical binding]; other site 1206780008277 dimerization interface [polypeptide binding]; other site 1206780008278 allosteric effector site; other site 1206780008279 fructose-1,6-bisphosphate binding site; other site 1206780008280 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1206780008281 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1206780008282 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 1206780008283 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1206780008284 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1206780008285 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1206780008286 nucleotide binding pocket [chemical binding]; other site 1206780008287 K-X-D-G motif; other site 1206780008288 catalytic site [active] 1206780008289 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1206780008290 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1206780008291 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1206780008292 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1206780008293 Dimer interface [polypeptide binding]; other site 1206780008294 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1206780008295 PknH-like extracellular domain; Region: PknH_C; pfam14032 1206780008296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1206780008297 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780008298 PPE family; Region: PPE; pfam00823 1206780008299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1206780008300 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780008301 PPE family; Region: PPE; pfam00823 1206780008302 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1206780008303 MULE transposase domain; Region: MULE; pfam10551 1206780008304 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1206780008305 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1206780008306 Ligand Binding Site [chemical binding]; other site 1206780008307 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1206780008308 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1206780008309 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206780008310 catalytic residue [active] 1206780008311 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1206780008312 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1206780008313 putative acyl-acceptor binding pocket; other site 1206780008314 Putative hemolysin [General function prediction only]; Region: COG3176 1206780008315 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1206780008316 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1206780008317 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1206780008318 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1206780008319 Ligand binding site [chemical binding]; other site 1206780008320 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1206780008321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780008322 S-adenosylmethionine binding site [chemical binding]; other site 1206780008323 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1206780008324 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1206780008325 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1206780008326 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1206780008327 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1206780008328 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1206780008329 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1206780008330 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1206780008331 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1206780008332 trimer interface [polypeptide binding]; other site 1206780008333 active site 1206780008334 substrate binding site [chemical binding]; other site 1206780008335 CoA binding site [chemical binding]; other site 1206780008336 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1206780008337 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1206780008338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780008339 S-adenosylmethionine binding site [chemical binding]; other site 1206780008340 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780008341 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1206780008342 substrate binding site [chemical binding]; other site 1206780008343 oxyanion hole (OAH) forming residues; other site 1206780008344 trimer interface [polypeptide binding]; other site 1206780008345 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1206780008346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206780008347 Walker A/P-loop; other site 1206780008348 ATP binding site [chemical binding]; other site 1206780008349 Q-loop/lid; other site 1206780008350 ABC transporter signature motif; other site 1206780008351 Walker B; other site 1206780008352 D-loop; other site 1206780008353 H-loop/switch region; other site 1206780008354 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1206780008355 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1206780008356 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1206780008357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206780008358 motif II; other site 1206780008359 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1206780008360 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1206780008361 D-pathway; other site 1206780008362 Putative ubiquinol binding site [chemical binding]; other site 1206780008363 Low-spin heme (heme b) binding site [chemical binding]; other site 1206780008364 Putative water exit pathway; other site 1206780008365 Binuclear center (heme o3/CuB) [ion binding]; other site 1206780008366 K-pathway; other site 1206780008367 Putative proton exit pathway; other site 1206780008368 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1206780008369 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1206780008370 siderophore binding site; other site 1206780008371 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1206780008372 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1206780008373 putative NAD(P) binding site [chemical binding]; other site 1206780008374 putative substrate binding site [chemical binding]; other site 1206780008375 catalytic Zn binding site [ion binding]; other site 1206780008376 structural Zn binding site [ion binding]; other site 1206780008377 dimer interface [polypeptide binding]; other site 1206780008378 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1206780008379 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1206780008380 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1206780008381 dimer interface [polypeptide binding]; other site 1206780008382 putative radical transfer pathway; other site 1206780008383 diiron center [ion binding]; other site 1206780008384 tyrosyl radical; other site 1206780008385 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1206780008386 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1206780008387 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780008388 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780008389 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1206780008390 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1206780008391 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1206780008392 active site 1206780008393 dimer interface [polypeptide binding]; other site 1206780008394 catalytic residues [active] 1206780008395 effector binding site; other site 1206780008396 R2 peptide binding site; other site 1206780008397 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1206780008398 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1206780008399 catalytic residues [active] 1206780008400 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1206780008401 Predicted flavoprotein [General function prediction only]; Region: COG0431 1206780008402 DNA polymerase IV; Validated; Region: PRK03352 1206780008403 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1206780008404 active site 1206780008405 DNA binding site [nucleotide binding] 1206780008406 short chain dehydrogenase; Provisional; Region: PRK07832 1206780008407 classical (c) SDRs; Region: SDR_c; cd05233 1206780008408 NAD(P) binding site [chemical binding]; other site 1206780008409 active site 1206780008410 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780008411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780008412 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780008413 Cytochrome P450; Region: p450; cl12078 1206780008414 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1206780008415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206780008416 DNA-binding site [nucleotide binding]; DNA binding site 1206780008417 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1206780008418 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1206780008419 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1206780008420 DNA-binding site [nucleotide binding]; DNA binding site 1206780008421 FCD domain; Region: FCD; pfam07729 1206780008422 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780008423 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1206780008424 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780008425 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780008426 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780008427 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780008428 active site 1206780008429 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1206780008430 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1206780008431 active site 1206780008432 DNA binding site [nucleotide binding] 1206780008433 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1206780008434 DNA binding site [nucleotide binding] 1206780008435 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1206780008436 Carbon starvation protein CstA; Region: CstA; pfam02554 1206780008437 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1206780008438 Predicted membrane protein [Function unknown]; Region: COG2259 1206780008439 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1206780008440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1206780008441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780008442 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1206780008443 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1206780008444 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1206780008445 active site 1206780008446 substrate binding site [chemical binding]; other site 1206780008447 metal binding site [ion binding]; metal-binding site 1206780008448 camphor resistance protein CrcB; Provisional; Region: PRK14216 1206780008449 camphor resistance protein CrcB; Provisional; Region: PRK14228 1206780008450 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1206780008451 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1206780008452 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 1206780008453 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1206780008454 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1206780008455 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780008456 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780008457 active site 1206780008458 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1206780008459 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1206780008460 putative hydrophobic ligand binding site [chemical binding]; other site 1206780008461 protein interface [polypeptide binding]; other site 1206780008462 gate; other site 1206780008463 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1206780008464 Sulfatase; Region: Sulfatase; pfam00884 1206780008465 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1206780008466 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1206780008467 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1206780008468 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1206780008469 active site 1206780008470 ATP binding site [chemical binding]; other site 1206780008471 substrate binding site [chemical binding]; other site 1206780008472 activation loop (A-loop); other site 1206780008473 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1206780008474 AAA ATPase domain; Region: AAA_16; pfam13191 1206780008475 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 1206780008476 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1206780008477 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1206780008478 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206780008479 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1206780008480 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1206780008481 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1206780008482 short chain dehydrogenase; Provisional; Region: PRK07832 1206780008483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780008484 NAD(P) binding site [chemical binding]; other site 1206780008485 active site 1206780008486 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1206780008487 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1206780008488 NAD binding site [chemical binding]; other site 1206780008489 catalytic Zn binding site [ion binding]; other site 1206780008490 substrate binding site [chemical binding]; other site 1206780008491 structural Zn binding site [ion binding]; other site 1206780008492 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1206780008493 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1206780008494 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1206780008495 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1206780008496 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1206780008497 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1206780008498 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780008499 acyl-activating enzyme (AAE) consensus motif; other site 1206780008500 AMP binding site [chemical binding]; other site 1206780008501 active site 1206780008502 CoA binding site [chemical binding]; other site 1206780008503 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1206780008504 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1206780008505 Patatin-like phospholipase; Region: Patatin; pfam01734 1206780008506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1206780008507 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1206780008508 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1206780008509 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780008510 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780008511 active site 1206780008512 Predicted transcriptional regulators [Transcription]; Region: COG1733 1206780008513 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206780008514 dimerization interface [polypeptide binding]; other site 1206780008515 putative DNA binding site [nucleotide binding]; other site 1206780008516 putative Zn2+ binding site [ion binding]; other site 1206780008517 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1206780008518 PE family; Region: PE; pfam00934 1206780008519 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1206780008520 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1206780008521 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1206780008522 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1206780008523 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1206780008524 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1206780008525 SmpB-tmRNA interface; other site 1206780008526 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1206780008527 FtsX-like permease family; Region: FtsX; pfam02687 1206780008528 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1206780008529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1206780008530 Walker A/P-loop; other site 1206780008531 ATP binding site [chemical binding]; other site 1206780008532 Q-loop/lid; other site 1206780008533 ABC transporter signature motif; other site 1206780008534 Walker B; other site 1206780008535 D-loop; other site 1206780008536 H-loop/switch region; other site 1206780008537 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1206780008538 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1206780008539 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1206780008540 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1206780008541 RF-1 domain; Region: RF-1; pfam00472 1206780008542 ferredoxin-NADP+ reductase; Region: PLN02852 1206780008543 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1206780008544 FAD binding domain; Region: FAD_binding_4; pfam01565 1206780008545 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 1206780008546 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206780008547 FeS/SAM binding site; other site 1206780008548 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1206780008549 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1206780008550 aromatic arch; other site 1206780008551 DCoH dimer interaction site [polypeptide binding]; other site 1206780008552 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1206780008553 DCoH tetramer interaction site [polypeptide binding]; other site 1206780008554 substrate binding site [chemical binding]; other site 1206780008555 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1206780008556 trimer interface [polypeptide binding]; other site 1206780008557 dimer interface [polypeptide binding]; other site 1206780008558 putative active site [active] 1206780008559 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1206780008560 MoaE interaction surface [polypeptide binding]; other site 1206780008561 MoeB interaction surface [polypeptide binding]; other site 1206780008562 thiocarboxylated glycine; other site 1206780008563 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1206780008564 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1206780008565 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1206780008566 nucleoside/Zn binding site; other site 1206780008567 dimer interface [polypeptide binding]; other site 1206780008568 catalytic motif [active] 1206780008569 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1206780008570 MULE transposase domain; Region: MULE; pfam10551 1206780008571 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1206780008572 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1206780008573 ATP binding site [chemical binding]; other site 1206780008574 substrate interface [chemical binding]; other site 1206780008575 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1206780008576 active site residue [active] 1206780008577 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1206780008578 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1206780008579 active site residue [active] 1206780008580 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1206780008581 active site residue [active] 1206780008582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1206780008583 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1206780008584 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1206780008585 DNA binding site [nucleotide binding] 1206780008586 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780008587 PPE family; Region: PPE; pfam00823 1206780008588 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1206780008589 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1206780008590 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1206780008591 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1206780008592 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1206780008593 dimer interface [polypeptide binding]; other site 1206780008594 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1206780008595 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1206780008596 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1206780008597 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1206780008598 Histidine kinase; Region: HisKA_3; pfam07730 1206780008599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206780008600 ATP binding site [chemical binding]; other site 1206780008601 Mg2+ binding site [ion binding]; other site 1206780008602 G-X-G motif; other site 1206780008603 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1206780008604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206780008605 active site 1206780008606 phosphorylation site [posttranslational modification] 1206780008607 intermolecular recognition site; other site 1206780008608 dimerization interface [polypeptide binding]; other site 1206780008609 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1206780008610 DNA binding residues [nucleotide binding] 1206780008611 dimerization interface [polypeptide binding]; other site 1206780008612 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1206780008613 Ligand Binding Site [chemical binding]; other site 1206780008614 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780008615 PPE family; Region: PPE; pfam00823 1206780008616 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780008617 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780008618 PPE family; Region: PPE; pfam00823 1206780008619 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780008620 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1206780008621 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1206780008622 active site 1206780008623 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1206780008624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206780008625 FeS/SAM binding site; other site 1206780008626 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780008627 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780008628 active site 1206780008629 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780008630 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780008631 active site 1206780008632 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1206780008633 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1206780008634 NAD(P) binding site [chemical binding]; other site 1206780008635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206780008636 active site 1206780008637 phosphorylation site [posttranslational modification] 1206780008638 intermolecular recognition site; other site 1206780008639 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780008640 PPE family; Region: PPE; pfam00823 1206780008641 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1206780008642 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1206780008643 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1206780008644 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1206780008645 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1206780008646 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1206780008647 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1206780008648 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1206780008649 putative dimer interface [polypeptide binding]; other site 1206780008650 [2Fe-2S] cluster binding site [ion binding]; other site 1206780008651 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1206780008652 SLBB domain; Region: SLBB; pfam10531 1206780008653 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1206780008654 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1206780008655 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1206780008656 catalytic loop [active] 1206780008657 iron binding site [ion binding]; other site 1206780008658 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1206780008659 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1206780008660 [4Fe-4S] binding site [ion binding]; other site 1206780008661 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1206780008662 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1206780008663 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1206780008664 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1206780008665 4Fe-4S binding domain; Region: Fer4; pfam00037 1206780008666 4Fe-4S binding domain; Region: Fer4; pfam00037 1206780008667 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1206780008668 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1206780008669 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1206780008670 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1206780008671 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1206780008672 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1206780008673 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1206780008674 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1206780008675 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1206780008676 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780008677 PPE family; Region: PPE; pfam00823 1206780008678 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780008679 PPE family; Region: PPE; pfam00823 1206780008680 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1206780008681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780008682 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1206780008683 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1206780008684 [2Fe-2S] cluster binding site [ion binding]; other site 1206780008685 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 1206780008686 putative alpha subunit interface [polypeptide binding]; other site 1206780008687 putative active site [active] 1206780008688 putative substrate binding site [chemical binding]; other site 1206780008689 Fe binding site [ion binding]; other site 1206780008690 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1206780008691 Protein of unknown function DUF58; Region: DUF58; pfam01882 1206780008692 MoxR-like ATPases [General function prediction only]; Region: COG0714 1206780008693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780008694 Walker A motif; other site 1206780008695 ATP binding site [chemical binding]; other site 1206780008696 Walker B motif; other site 1206780008697 arginine finger; other site 1206780008698 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1206780008699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780008700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780008701 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1206780008702 putative active site [active] 1206780008703 putative substrate binding site [chemical binding]; other site 1206780008704 ATP binding site [chemical binding]; other site 1206780008705 Phosphotransferase enzyme family; Region: APH; pfam01636 1206780008706 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1206780008707 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1206780008708 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1206780008709 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206780008710 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1206780008711 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780008712 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780008713 short chain dehydrogenase; Validated; Region: PRK08264 1206780008714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780008715 NAD(P) binding site [chemical binding]; other site 1206780008716 active site 1206780008717 amidase; Provisional; Region: PRK06170 1206780008718 Amidase; Region: Amidase; pfam01425 1206780008719 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1206780008720 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206780008721 TAP-like protein; Region: Abhydrolase_4; pfam08386 1206780008722 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1206780008723 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1206780008724 AAA domain; Region: AAA_14; pfam13173 1206780008725 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1206780008726 putative active site [active] 1206780008727 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1206780008728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1206780008729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1206780008730 non-specific DNA binding site [nucleotide binding]; other site 1206780008731 salt bridge; other site 1206780008732 sequence-specific DNA binding site [nucleotide binding]; other site 1206780008733 RES domain; Region: RES; pfam08808 1206780008734 Winged helix-turn helix; Region: HTH_29; pfam13551 1206780008735 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1206780008736 Helix-turn-helix domain; Region: HTH_38; pfam13936 1206780008737 Integrase core domain; Region: rve; pfam00665 1206780008738 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1206780008739 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1206780008740 hypothetical protein; Validated; Region: PRK00068 1206780008741 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1206780008742 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1206780008743 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1206780008744 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1206780008745 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1206780008746 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1206780008747 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1206780008748 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1206780008749 ABC1 family; Region: ABC1; pfam03109 1206780008750 Phosphotransferase enzyme family; Region: APH; pfam01636 1206780008751 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1206780008752 active site 1206780008753 ATP binding site [chemical binding]; other site 1206780008754 Transcription factor WhiB; Region: Whib; pfam02467 1206780008755 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1206780008756 Part of AAA domain; Region: AAA_19; pfam13245 1206780008757 Family description; Region: UvrD_C_2; pfam13538 1206780008758 HRDC domain; Region: HRDC; pfam00570 1206780008759 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1206780008760 catalytic residues [active] 1206780008761 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1206780008762 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1206780008763 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1206780008764 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1206780008765 putative NADH binding site [chemical binding]; other site 1206780008766 putative active site [active] 1206780008767 nudix motif; other site 1206780008768 putative metal binding site [ion binding]; other site 1206780008769 Ion channel; Region: Ion_trans_2; pfam07885 1206780008770 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1206780008771 TrkA-N domain; Region: TrkA_N; pfam02254 1206780008772 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1206780008773 Part of AAA domain; Region: AAA_19; pfam13245 1206780008774 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1206780008775 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1206780008776 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1206780008777 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1206780008778 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206780008779 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1206780008780 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1206780008781 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1206780008782 active site 1206780008783 DNA binding site [nucleotide binding] 1206780008784 TIGR02569 family protein; Region: TIGR02569_actnb 1206780008785 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1206780008786 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1206780008787 ATP binding site [chemical binding]; other site 1206780008788 substrate interface [chemical binding]; other site 1206780008789 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1206780008790 active site residue [active] 1206780008791 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1206780008792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780008793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780008794 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1206780008795 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1206780008796 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1206780008797 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1206780008798 ATP binding site [chemical binding]; other site 1206780008799 Mg++ binding site [ion binding]; other site 1206780008800 motif III; other site 1206780008801 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206780008802 nucleotide binding region [chemical binding]; other site 1206780008803 ATP-binding site [chemical binding]; other site 1206780008804 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1206780008805 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206780008806 P-loop; other site 1206780008807 Magnesium ion binding site [ion binding]; other site 1206780008808 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206780008809 Magnesium ion binding site [ion binding]; other site 1206780008810 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206780008811 catalytic core [active] 1206780008812 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1206780008813 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1206780008814 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1206780008815 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1206780008816 Transcription factor WhiB; Region: Whib; pfam02467 1206780008817 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1206780008818 PAS domain S-box; Region: sensory_box; TIGR00229 1206780008819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1206780008820 Histidine kinase; Region: HisKA_2; pfam07568 1206780008821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206780008822 ATP binding site [chemical binding]; other site 1206780008823 Mg2+ binding site [ion binding]; other site 1206780008824 G-X-G motif; other site 1206780008825 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1206780008826 carboxyltransferase (CT) interaction site; other site 1206780008827 biotinylation site [posttranslational modification]; other site 1206780008828 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1206780008829 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1206780008830 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206780008831 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206780008832 DNA binding residues [nucleotide binding] 1206780008833 short chain dehydrogenase; Provisional; Region: PRK08278 1206780008834 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1206780008835 NAD(P) binding site [chemical binding]; other site 1206780008836 homodimer interface [polypeptide binding]; other site 1206780008837 active site 1206780008838 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1206780008839 putative deacylase active site [active] 1206780008840 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1206780008841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206780008842 Coenzyme A binding pocket [chemical binding]; other site 1206780008843 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1206780008844 Phosphotransferase enzyme family; Region: APH; pfam01636 1206780008845 putative active site [active] 1206780008846 putative substrate binding site [chemical binding]; other site 1206780008847 ATP binding site [chemical binding]; other site 1206780008848 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1206780008849 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1206780008850 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1206780008851 hinge; other site 1206780008852 active site 1206780008853 Predicted GTPases [General function prediction only]; Region: COG1162 1206780008854 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1206780008855 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1206780008856 GTP/Mg2+ binding site [chemical binding]; other site 1206780008857 G4 box; other site 1206780008858 G5 box; other site 1206780008859 G1 box; other site 1206780008860 Switch I region; other site 1206780008861 G2 box; other site 1206780008862 G3 box; other site 1206780008863 Switch II region; other site 1206780008864 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1206780008865 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1206780008866 putative di-iron ligands [ion binding]; other site 1206780008867 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1206780008868 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1206780008869 FAD binding pocket [chemical binding]; other site 1206780008870 FAD binding motif [chemical binding]; other site 1206780008871 phosphate binding motif [ion binding]; other site 1206780008872 beta-alpha-beta structure motif; other site 1206780008873 NAD binding pocket [chemical binding]; other site 1206780008874 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1206780008875 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1206780008876 catalytic loop [active] 1206780008877 iron binding site [ion binding]; other site 1206780008878 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1206780008879 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1206780008880 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1206780008881 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1206780008882 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1206780008883 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1206780008884 TrkA-C domain; Region: TrkA_C; pfam02080 1206780008885 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1206780008886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780008887 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1206780008888 putative substrate translocation pore; other site 1206780008889 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1206780008890 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1206780008891 ligand binding site [chemical binding]; other site 1206780008892 flexible hinge region; other site 1206780008893 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1206780008894 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1206780008895 nucleophile elbow; other site 1206780008896 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1206780008897 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1206780008898 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1206780008899 30S subunit binding site; other site 1206780008900 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1206780008901 active site 1206780008902 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1206780008903 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1206780008904 lipoprotein LpqB; Provisional; Region: PRK13616 1206780008905 Sporulation and spore germination; Region: Germane; pfam10646 1206780008906 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1206780008907 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1206780008908 dimerization interface [polypeptide binding]; other site 1206780008909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206780008910 dimer interface [polypeptide binding]; other site 1206780008911 phosphorylation site [posttranslational modification] 1206780008912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206780008913 ATP binding site [chemical binding]; other site 1206780008914 Mg2+ binding site [ion binding]; other site 1206780008915 G-X-G motif; other site 1206780008916 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206780008917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206780008918 active site 1206780008919 phosphorylation site [posttranslational modification] 1206780008920 intermolecular recognition site; other site 1206780008921 dimerization interface [polypeptide binding]; other site 1206780008922 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206780008923 DNA binding site [nucleotide binding] 1206780008924 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1206780008925 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1206780008926 TMP-binding site; other site 1206780008927 ATP-binding site [chemical binding]; other site 1206780008928 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1206780008929 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1206780008930 homotetramer interface [polypeptide binding]; other site 1206780008931 ligand binding site [chemical binding]; other site 1206780008932 catalytic site [active] 1206780008933 NAD binding site [chemical binding]; other site 1206780008934 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780008935 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1206780008936 Rubredoxin [Energy production and conversion]; Region: COG1773 1206780008937 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1206780008938 iron binding site [ion binding]; other site 1206780008939 Rubredoxin [Energy production and conversion]; Region: COG1773 1206780008940 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1206780008941 iron binding site [ion binding]; other site 1206780008942 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1206780008943 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1206780008944 Di-iron ligands [ion binding]; other site 1206780008945 amino acid transporter; Region: 2A0306; TIGR00909 1206780008946 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1206780008947 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1206780008948 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1206780008949 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1206780008950 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1206780008951 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1206780008952 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1206780008953 active site 1206780008954 substrate binding site [chemical binding]; other site 1206780008955 metal binding site [ion binding]; metal-binding site 1206780008956 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1206780008957 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1206780008958 Transcription factor WhiB; Region: Whib; pfam02467 1206780008959 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1206780008960 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 1206780008961 phosphate binding site [ion binding]; other site 1206780008962 dimer interface [polypeptide binding]; other site 1206780008963 substrate binding site [chemical binding]; other site 1206780008964 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1206780008965 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1206780008966 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1206780008967 putative FMN binding site [chemical binding]; other site 1206780008968 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1206780008969 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1206780008970 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1206780008971 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1206780008972 active site 1206780008973 Substrate binding site; other site 1206780008974 Mg++ binding site; other site 1206780008975 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1206780008976 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1206780008977 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1206780008978 Probable Catalytic site; other site 1206780008979 metal-binding site 1206780008980 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 1206780008981 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1206780008982 NADP binding site [chemical binding]; other site 1206780008983 active site 1206780008984 putative substrate binding site [chemical binding]; other site 1206780008985 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1206780008986 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1206780008987 TIGR03089 family protein; Region: TIGR03089 1206780008988 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1206780008989 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1206780008990 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206780008991 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1206780008992 active site 1206780008993 motif I; other site 1206780008994 motif II; other site 1206780008995 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1206780008996 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1206780008997 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1206780008998 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1206780008999 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1206780009000 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 1206780009001 active site clefts [active] 1206780009002 zinc binding site [ion binding]; other site 1206780009003 dimer interface [polypeptide binding]; other site 1206780009004 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780009005 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1206780009006 FAD binding site [chemical binding]; other site 1206780009007 homotetramer interface [polypeptide binding]; other site 1206780009008 substrate binding pocket [chemical binding]; other site 1206780009009 catalytic base [active] 1206780009010 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1206780009011 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 1206780009012 ATP-grasp domain; Region: ATP-grasp; pfam02222 1206780009013 Predicted membrane protein [Function unknown]; Region: COG2246 1206780009014 GtrA-like protein; Region: GtrA; pfam04138 1206780009015 Bacterial PH domain; Region: DUF304; pfam03703 1206780009016 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1206780009017 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1206780009018 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1206780009019 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1206780009020 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1206780009021 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1206780009022 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1206780009023 Maf-like protein; Region: Maf; pfam02545 1206780009024 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1206780009025 active site 1206780009026 dimer interface [polypeptide binding]; other site 1206780009027 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1206780009028 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1206780009029 active site residue [active] 1206780009030 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1206780009031 active site residue [active] 1206780009032 Fe-S metabolism associated domain; Region: SufE; pfam02657 1206780009033 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1206780009034 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1206780009035 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1206780009036 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1206780009037 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1206780009038 carboxyltransferase (CT) interaction site; other site 1206780009039 biotinylation site [posttranslational modification]; other site 1206780009040 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1206780009041 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206780009042 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1206780009043 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1206780009044 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1206780009045 L-lysine aminotransferase; Provisional; Region: PRK08297 1206780009046 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1206780009047 inhibitor-cofactor binding pocket; inhibition site 1206780009048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780009049 catalytic residue [active] 1206780009050 putative DNA binding site [nucleotide binding]; other site 1206780009051 dimerization interface [polypeptide binding]; other site 1206780009052 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1206780009053 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1206780009054 putative Zn2+ binding site [ion binding]; other site 1206780009055 AsnC family; Region: AsnC_trans_reg; pfam01037 1206780009056 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1206780009057 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1206780009058 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1206780009059 tetrameric interface [polypeptide binding]; other site 1206780009060 NAD binding site [chemical binding]; other site 1206780009061 catalytic residues [active] 1206780009062 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1206780009063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780009064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780009065 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206780009066 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1206780009067 ATP binding site [chemical binding]; other site 1206780009068 putative Mg++ binding site [ion binding]; other site 1206780009069 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206780009070 nucleotide binding region [chemical binding]; other site 1206780009071 ATP-binding site [chemical binding]; other site 1206780009072 DEAD/H associated; Region: DEAD_assoc; pfam08494 1206780009073 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1206780009074 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1206780009075 putative DNA binding site [nucleotide binding]; other site 1206780009076 catalytic residue [active] 1206780009077 putative H2TH interface [polypeptide binding]; other site 1206780009078 putative catalytic residues [active] 1206780009079 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1206780009080 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1206780009081 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1206780009082 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1206780009083 Sulfatase; Region: Sulfatase; pfam00884 1206780009084 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1206780009085 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1206780009086 probable active site [active] 1206780009087 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1206780009088 PhoU domain; Region: PhoU; pfam01895 1206780009089 PhoU domain; Region: PhoU; pfam01895 1206780009090 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1206780009091 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1206780009092 AAA domain; Region: AAA_31; pfam13614 1206780009093 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206780009094 P-loop; other site 1206780009095 Magnesium ion binding site [ion binding]; other site 1206780009096 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 1206780009097 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206780009098 Magnesium ion binding site [ion binding]; other site 1206780009099 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206780009100 catalytic core [active] 1206780009101 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1206780009102 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1206780009103 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1206780009104 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1206780009105 Transcription factor WhiB; Region: Whib; pfam02467 1206780009106 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1206780009107 PAS domain S-box; Region: sensory_box; TIGR00229 1206780009108 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1206780009109 Histidine kinase; Region: HisKA_2; pfam07568 1206780009110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206780009111 ATP binding site [chemical binding]; other site 1206780009112 Mg2+ binding site [ion binding]; other site 1206780009113 G-X-G motif; other site 1206780009114 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1206780009115 carboxyltransferase (CT) interaction site; other site 1206780009116 biotinylation site [posttranslational modification]; other site 1206780009117 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1206780009118 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1206780009119 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206780009120 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206780009121 DNA binding residues [nucleotide binding] 1206780009122 short chain dehydrogenase; Provisional; Region: PRK08278 1206780009123 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1206780009124 NAD(P) binding site [chemical binding]; other site 1206780009125 homodimer interface [polypeptide binding]; other site 1206780009126 active site 1206780009127 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1206780009128 putative deacylase active site [active] 1206780009129 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1206780009130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206780009131 Coenzyme A binding pocket [chemical binding]; other site 1206780009132 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1206780009133 Phosphotransferase enzyme family; Region: APH; pfam01636 1206780009134 putative active site [active] 1206780009135 putative substrate binding site [chemical binding]; other site 1206780009136 ATP binding site [chemical binding]; other site 1206780009137 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1206780009138 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1206780009139 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1206780009140 hinge; other site 1206780009141 active site 1206780009142 Predicted GTPases [General function prediction only]; Region: COG1162 1206780009143 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1206780009144 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1206780009145 GTP/Mg2+ binding site [chemical binding]; other site 1206780009146 G4 box; other site 1206780009147 G5 box; other site 1206780009148 G1 box; other site 1206780009149 Switch I region; other site 1206780009150 G2 box; other site 1206780009151 G3 box; other site 1206780009152 Switch II region; other site 1206780009153 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1206780009154 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1206780009155 putative di-iron ligands [ion binding]; other site 1206780009156 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1206780009157 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1206780009158 FAD binding pocket [chemical binding]; other site 1206780009159 FAD binding motif [chemical binding]; other site 1206780009160 phosphate binding motif [ion binding]; other site 1206780009161 beta-alpha-beta structure motif; other site 1206780009162 NAD binding pocket [chemical binding]; other site 1206780009163 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1206780009164 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1206780009165 catalytic loop [active] 1206780009166 iron binding site [ion binding]; other site 1206780009167 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1206780009168 putative DNA binding site [nucleotide binding]; other site 1206780009169 dimerization interface [polypeptide binding]; other site 1206780009170 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1206780009171 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1206780009172 putative Zn2+ binding site [ion binding]; other site 1206780009173 AsnC family; Region: AsnC_trans_reg; pfam01037 1206780009174 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1206780009175 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1206780009176 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1206780009177 tetrameric interface [polypeptide binding]; other site 1206780009178 NAD binding site [chemical binding]; other site 1206780009179 catalytic residues [active] 1206780009180 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1206780009181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780009182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780009183 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206780009184 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1206780009185 ATP binding site [chemical binding]; other site 1206780009186 putative Mg++ binding site [ion binding]; other site 1206780009187 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206780009188 nucleotide binding region [chemical binding]; other site 1206780009189 ATP-binding site [chemical binding]; other site 1206780009190 DEAD/H associated; Region: DEAD_assoc; pfam08494 1206780009191 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1206780009192 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1206780009193 putative DNA binding site [nucleotide binding]; other site 1206780009194 catalytic residue [active] 1206780009195 putative H2TH interface [polypeptide binding]; other site 1206780009196 putative catalytic residues [active] 1206780009197 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1206780009198 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1206780009199 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1206780009200 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1206780009201 Sulfatase; Region: Sulfatase; pfam00884 1206780009202 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1206780009203 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1206780009204 probable active site [active] 1206780009205 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1206780009206 PhoU domain; Region: PhoU; pfam01895 1206780009207 PhoU domain; Region: PhoU; pfam01895 1206780009208 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1206780009209 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1206780009210 AAA domain; Region: AAA_31; pfam13614 1206780009211 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206780009212 P-loop; other site 1206780009213 Magnesium ion binding site [ion binding]; other site 1206780009214 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 1206780009215 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206780009216 Magnesium ion binding site [ion binding]; other site 1206780009217 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206780009218 catalytic core [active] 1206780009219 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1206780009220 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1206780009221 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1206780009222 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1206780009223 Transcription factor WhiB; Region: Whib; pfam02467 1206780009224 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1206780009225 PAS domain S-box; Region: sensory_box; TIGR00229 1206780009226 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1206780009227 Histidine kinase; Region: HisKA_2; pfam07568 1206780009228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206780009229 ATP binding site [chemical binding]; other site 1206780009230 Mg2+ binding site [ion binding]; other site 1206780009231 G-X-G motif; other site 1206780009232 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1206780009233 carboxyltransferase (CT) interaction site; other site 1206780009234 biotinylation site [posttranslational modification]; other site 1206780009235 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1206780009236 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1206780009237 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206780009238 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206780009239 DNA binding residues [nucleotide binding] 1206780009240 short chain dehydrogenase; Provisional; Region: PRK08278 1206780009241 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1206780009242 NAD(P) binding site [chemical binding]; other site 1206780009243 homodimer interface [polypeptide binding]; other site 1206780009244 active site 1206780009245 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1206780009246 putative deacylase active site [active] 1206780009247 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1206780009248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1206780009249 Coenzyme A binding pocket [chemical binding]; other site 1206780009250 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1206780009251 Phosphotransferase enzyme family; Region: APH; pfam01636 1206780009252 putative active site [active] 1206780009253 putative substrate binding site [chemical binding]; other site 1206780009254 ATP binding site [chemical binding]; other site 1206780009255 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1206780009256 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1206780009257 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1206780009258 hinge; other site 1206780009259 active site 1206780009260 Predicted GTPases [General function prediction only]; Region: COG1162 1206780009261 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1206780009262 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1206780009263 GTP/Mg2+ binding site [chemical binding]; other site 1206780009264 G4 box; other site 1206780009265 G5 box; other site 1206780009266 G1 box; other site 1206780009267 Switch I region; other site 1206780009268 G2 box; other site 1206780009269 G3 box; other site 1206780009270 Switch II region; other site 1206780009271 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1206780009272 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1206780009273 putative di-iron ligands [ion binding]; other site 1206780009274 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1206780009275 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1206780009276 FAD binding pocket [chemical binding]; other site 1206780009277 FAD binding motif [chemical binding]; other site 1206780009278 phosphate binding motif [ion binding]; other site 1206780009279 beta-alpha-beta structure motif; other site 1206780009280 NAD binding pocket [chemical binding]; other site 1206780009281 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1206780009282 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1206780009283 catalytic loop [active] 1206780009284 iron binding site [ion binding]; other site 1206780009285 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1206780009286 putative DNA binding site [nucleotide binding]; other site 1206780009287 dimerization interface [polypeptide binding]; other site 1206780009288 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1206780009289 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1206780009290 putative Zn2+ binding site [ion binding]; other site 1206780009291 AsnC family; Region: AsnC_trans_reg; pfam01037 1206780009292 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1206780009293 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1206780009294 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1206780009295 tetrameric interface [polypeptide binding]; other site 1206780009296 NAD binding site [chemical binding]; other site 1206780009297 catalytic residues [active] 1206780009298 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1206780009299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780009300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780009301 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206780009302 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1206780009303 ATP binding site [chemical binding]; other site 1206780009304 putative Mg++ binding site [ion binding]; other site 1206780009305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206780009306 nucleotide binding region [chemical binding]; other site 1206780009307 ATP-binding site [chemical binding]; other site 1206780009308 DEAD/H associated; Region: DEAD_assoc; pfam08494 1206780009309 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1206780009310 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1206780009311 putative DNA binding site [nucleotide binding]; other site 1206780009312 catalytic residue [active] 1206780009313 putative H2TH interface [polypeptide binding]; other site 1206780009314 putative catalytic residues [active] 1206780009315 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1206780009316 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1206780009317 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1206780009318 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1206780009319 Sulfatase; Region: Sulfatase; pfam00884 1206780009320 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1206780009321 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1206780009322 probable active site [active] 1206780009323 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1206780009324 PhoU domain; Region: PhoU; pfam01895 1206780009325 PhoU domain; Region: PhoU; pfam01895 1206780009326 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1206780009327 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1206780009328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206780009329 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1206780009330 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1206780009331 putative active site pocket [active] 1206780009332 dimerization interface [polypeptide binding]; other site 1206780009333 putative catalytic residue [active] 1206780009334 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1206780009335 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1206780009336 metal binding site [ion binding]; metal-binding site 1206780009337 putative dimer interface [polypeptide binding]; other site 1206780009338 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1206780009339 amidohydrolase; Region: amidohydrolases; TIGR01891 1206780009340 metal binding site [ion binding]; metal-binding site 1206780009341 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1206780009342 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1206780009343 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1206780009344 active site 1206780009345 substrate binding site [chemical binding]; other site 1206780009346 metal binding site [ion binding]; metal-binding site 1206780009347 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206780009348 active site 1206780009349 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1206780009350 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206780009351 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1206780009352 adenosine deaminase; Provisional; Region: PRK09358 1206780009353 active site 1206780009354 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1206780009355 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1206780009356 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1206780009357 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1206780009358 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1206780009359 active site 1206780009360 catalytic motif [active] 1206780009361 Zn binding site [ion binding]; other site 1206780009362 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1206780009363 putative Iron-sulfur protein interface [polypeptide binding]; other site 1206780009364 putative proximal heme binding site [chemical binding]; other site 1206780009365 putative SdhD-like interface [polypeptide binding]; other site 1206780009366 putative distal heme binding site [chemical binding]; other site 1206780009367 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1206780009368 putative Iron-sulfur protein interface [polypeptide binding]; other site 1206780009369 putative proximal heme binding site [chemical binding]; other site 1206780009370 putative SdhC-like subunit interface [polypeptide binding]; other site 1206780009371 putative distal heme binding site [chemical binding]; other site 1206780009372 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1206780009373 L-aspartate oxidase; Provisional; Region: PRK06175 1206780009374 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1206780009375 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1206780009376 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1206780009377 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1206780009378 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1206780009379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780009380 S-adenosylmethionine binding site [chemical binding]; other site 1206780009381 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1206780009382 MoaE interaction surface [polypeptide binding]; other site 1206780009383 MoeB interaction surface [polypeptide binding]; other site 1206780009384 thiocarboxylated glycine; other site 1206780009385 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1206780009386 MoaE homodimer interface [polypeptide binding]; other site 1206780009387 MoaD interaction [polypeptide binding]; other site 1206780009388 active site residues [active] 1206780009389 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1206780009390 trimer interface [polypeptide binding]; other site 1206780009391 dimer interface [polypeptide binding]; other site 1206780009392 putative active site [active] 1206780009393 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1206780009394 aromatic arch; other site 1206780009395 DCoH dimer interaction site [polypeptide binding]; other site 1206780009396 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1206780009397 DCoH tetramer interaction site [polypeptide binding]; other site 1206780009398 substrate binding site [chemical binding]; other site 1206780009399 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 1206780009400 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206780009401 FeS/SAM binding site; other site 1206780009402 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1206780009403 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1206780009404 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1206780009405 DNA binding site [nucleotide binding] 1206780009406 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1206780009407 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1206780009408 phosphopeptide binding site; other site 1206780009409 Condensation domain; Region: Condensation; pfam00668 1206780009410 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1206780009411 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1206780009412 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1206780009413 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1206780009414 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1206780009415 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206780009416 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206780009417 DNA binding residues [nucleotide binding] 1206780009418 SnoaL-like domain; Region: SnoaL_2; pfam12680 1206780009419 hypothetical protein; Provisional; Region: PRK06541 1206780009420 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1206780009421 inhibitor-cofactor binding pocket; inhibition site 1206780009422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780009423 catalytic residue [active] 1206780009424 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1206780009425 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1206780009426 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1206780009427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780009428 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1206780009429 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1206780009430 active site 1206780009431 dimer interface [polypeptide binding]; other site 1206780009432 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1206780009433 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1206780009434 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1206780009435 DNA binding residues [nucleotide binding] 1206780009436 dimer interface [polypeptide binding]; other site 1206780009437 metal binding site [ion binding]; metal-binding site 1206780009438 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1206780009439 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1206780009440 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1206780009441 active site 1206780009442 HIGH motif; other site 1206780009443 dimer interface [polypeptide binding]; other site 1206780009444 KMSKS motif; other site 1206780009445 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206780009446 isocitrate dehydrogenase; Validated; Region: PRK08299 1206780009447 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1206780009448 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1206780009449 homodimer interface [polypeptide binding]; other site 1206780009450 substrate-cofactor binding pocket; other site 1206780009451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780009452 catalytic residue [active] 1206780009453 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1206780009454 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1206780009455 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206780009456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780009457 S-adenosylmethionine binding site [chemical binding]; other site 1206780009458 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009459 PPE family; Region: PPE; pfam00823 1206780009460 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009461 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009462 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009463 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009464 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009465 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009466 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009467 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009468 PE family; Region: PE; pfam00934 1206780009469 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1206780009470 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009471 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009472 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009473 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009474 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009475 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009476 PPE family; Region: PPE; pfam00823 1206780009477 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009478 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009479 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009480 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009481 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009482 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009483 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1206780009484 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1206780009485 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009486 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009487 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009488 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009489 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009490 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009491 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009492 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009493 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009494 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009495 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009496 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009497 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009498 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009499 PPE family; Region: PPE; pfam00823 1206780009500 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009501 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009502 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009503 Berberine and berberine like; Region: BBE; pfam08031 1206780009504 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1206780009505 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1206780009506 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1206780009507 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1206780009508 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1206780009509 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1206780009510 homodimer interface [polypeptide binding]; other site 1206780009511 NADP binding site [chemical binding]; other site 1206780009512 substrate binding site [chemical binding]; other site 1206780009513 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1206780009514 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1206780009515 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1206780009516 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1206780009517 active site 1206780009518 FMN binding site [chemical binding]; other site 1206780009519 substrate binding site [chemical binding]; other site 1206780009520 putative catalytic residue [active] 1206780009521 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1206780009522 phosphate binding site [ion binding]; other site 1206780009523 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1206780009524 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1206780009525 phosphopeptide binding site; other site 1206780009526 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1206780009527 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1206780009528 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1206780009529 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1206780009530 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1206780009531 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1206780009532 G1 box; other site 1206780009533 GTP/Mg2+ binding site [chemical binding]; other site 1206780009534 G2 box; other site 1206780009535 Switch I region; other site 1206780009536 G3 box; other site 1206780009537 Switch II region; other site 1206780009538 G4 box; other site 1206780009539 G5 box; other site 1206780009540 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1206780009541 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1206780009542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1206780009543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206780009544 ATP binding site [chemical binding]; other site 1206780009545 Mg2+ binding site [ion binding]; other site 1206780009546 G-X-G motif; other site 1206780009547 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1206780009548 PE family; Region: PE; pfam00934 1206780009549 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1206780009550 FMN binding site [chemical binding]; other site 1206780009551 dimer interface [polypeptide binding]; other site 1206780009552 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1206780009553 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1206780009554 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1206780009555 active site 1206780009556 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1206780009557 generic binding surface II; other site 1206780009558 generic binding surface I; other site 1206780009559 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1206780009560 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1206780009561 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1206780009562 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1206780009563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206780009564 active site 1206780009565 motif I; other site 1206780009566 motif II; other site 1206780009567 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1206780009568 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780009569 substrate binding site [chemical binding]; other site 1206780009570 oxyanion hole (OAH) forming residues; other site 1206780009571 trimer interface [polypeptide binding]; other site 1206780009572 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1206780009573 Amidase; Region: Amidase; pfam01425 1206780009574 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1206780009575 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206780009576 motif II; other site 1206780009577 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1206780009578 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1206780009579 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 1206780009580 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1206780009581 TPP-binding site; other site 1206780009582 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1206780009583 PYR/PP interface [polypeptide binding]; other site 1206780009584 dimer interface [polypeptide binding]; other site 1206780009585 TPP binding site [chemical binding]; other site 1206780009586 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1206780009587 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1206780009588 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1206780009589 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1206780009590 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1206780009591 substrate binding pocket [chemical binding]; other site 1206780009592 chain length determination region; other site 1206780009593 substrate-Mg2+ binding site; other site 1206780009594 catalytic residues [active] 1206780009595 aspartate-rich region 1; other site 1206780009596 active site lid residues [active] 1206780009597 aspartate-rich region 2; other site 1206780009598 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1206780009599 putative active site [active] 1206780009600 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1206780009601 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1206780009602 Transposase domain (DUF772); Region: DUF772; pfam05598 1206780009603 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1206780009604 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1206780009605 PE family; Region: PE; pfam00934 1206780009606 enoyl-CoA hydratase; Region: PLN02864 1206780009607 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1206780009608 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1206780009609 dimer interaction site [polypeptide binding]; other site 1206780009610 substrate-binding tunnel; other site 1206780009611 active site 1206780009612 catalytic site [active] 1206780009613 substrate binding site [chemical binding]; other site 1206780009614 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206780009615 short chain dehydrogenase; Provisional; Region: PRK07201 1206780009616 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1206780009617 putative NAD(P) binding site [chemical binding]; other site 1206780009618 active site 1206780009619 putative substrate binding site [chemical binding]; other site 1206780009620 classical (c) SDRs; Region: SDR_c; cd05233 1206780009621 NAD(P) binding site [chemical binding]; other site 1206780009622 active site 1206780009623 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1206780009624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780009625 S-adenosylmethionine binding site [chemical binding]; other site 1206780009626 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1206780009627 active site 1206780009628 DNA Polymerase Y-family; Region: PolY_like; cd03468 1206780009629 DNA binding site [nucleotide binding] 1206780009630 GMP synthase; Reviewed; Region: guaA; PRK00074 1206780009631 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1206780009632 AMP/PPi binding site [chemical binding]; other site 1206780009633 candidate oxyanion hole; other site 1206780009634 catalytic triad [active] 1206780009635 potential glutamine specificity residues [chemical binding]; other site 1206780009636 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1206780009637 ATP Binding subdomain [chemical binding]; other site 1206780009638 Ligand Binding sites [chemical binding]; other site 1206780009639 Dimerization subdomain; other site 1206780009640 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1206780009641 active site lid residues [active] 1206780009642 substrate binding pocket [chemical binding]; other site 1206780009643 catalytic residues [active] 1206780009644 substrate-Mg2+ binding site; other site 1206780009645 aspartate-rich region 1; other site 1206780009646 aspartate-rich region 2; other site 1206780009647 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1206780009648 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1206780009649 substrate binding pocket [chemical binding]; other site 1206780009650 chain length determination region; other site 1206780009651 substrate-Mg2+ binding site; other site 1206780009652 catalytic residues [active] 1206780009653 aspartate-rich region 1; other site 1206780009654 active site lid residues [active] 1206780009655 aspartate-rich region 2; other site 1206780009656 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1206780009657 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1206780009658 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1206780009659 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1206780009660 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1206780009661 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1206780009662 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1206780009663 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1206780009664 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1206780009665 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1206780009666 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206780009667 catalytic residue [active] 1206780009668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1206780009669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206780009670 hypothetical protein; Provisional; Region: PRK07579 1206780009671 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1206780009672 active site 1206780009673 cosubstrate binding site; other site 1206780009674 substrate binding site [chemical binding]; other site 1206780009675 catalytic site [active] 1206780009676 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780009677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780009678 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1206780009679 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1206780009680 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1206780009681 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1206780009682 putative active site [active] 1206780009683 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1206780009684 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1206780009685 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1206780009686 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1206780009687 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1206780009688 phosphate binding site [ion binding]; other site 1206780009689 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1206780009690 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1206780009691 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1206780009692 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1206780009693 active site 1206780009694 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1206780009695 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206780009696 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206780009697 DNA binding residues [nucleotide binding] 1206780009698 Transcription factor WhiB; Region: Whib; pfam02467 1206780009699 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1206780009700 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1206780009701 ring oligomerisation interface [polypeptide binding]; other site 1206780009702 ATP/Mg binding site [chemical binding]; other site 1206780009703 stacking interactions; other site 1206780009704 hinge regions; other site 1206780009705 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1206780009706 oligomerisation interface [polypeptide binding]; other site 1206780009707 mobile loop; other site 1206780009708 roof hairpin; other site 1206780009709 UGMP family protein; Validated; Region: PRK09604 1206780009710 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1206780009711 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1206780009712 Coenzyme A binding pocket [chemical binding]; other site 1206780009713 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1206780009714 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1206780009715 alanine racemase; Reviewed; Region: alr; PRK00053 1206780009716 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1206780009717 active site 1206780009718 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1206780009719 dimer interface [polypeptide binding]; other site 1206780009720 substrate binding site [chemical binding]; other site 1206780009721 catalytic residues [active] 1206780009722 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009723 PPE family; Region: PPE; pfam00823 1206780009724 Integrase core domain; Region: rve; pfam00665 1206780009725 Integrase core domain; Region: rve_3; pfam13683 1206780009726 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1206780009727 MULE transposase domain; Region: MULE; pfam10551 1206780009728 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1206780009729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780009730 catalytic residue [active] 1206780009731 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1206780009732 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1206780009733 putative substrate binding site [chemical binding]; other site 1206780009734 putative ATP binding site [chemical binding]; other site 1206780009735 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1206780009736 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1206780009737 glutaminase active site [active] 1206780009738 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1206780009739 dimer interface [polypeptide binding]; other site 1206780009740 active site 1206780009741 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1206780009742 dimer interface [polypeptide binding]; other site 1206780009743 active site 1206780009744 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1206780009745 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1206780009746 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1206780009747 active site 1206780009748 substrate binding site [chemical binding]; other site 1206780009749 metal binding site [ion binding]; metal-binding site 1206780009750 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1206780009751 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1206780009752 23S rRNA interface [nucleotide binding]; other site 1206780009753 L3 interface [polypeptide binding]; other site 1206780009754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1206780009755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1206780009756 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1206780009757 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1206780009758 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206780009759 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1206780009760 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206780009761 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206780009762 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1206780009763 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1206780009764 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1206780009765 active site 1206780009766 catalytic residues [active] 1206780009767 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1206780009768 Cutinase; Region: Cutinase; pfam01083 1206780009769 Cutinase; Region: Cutinase; pfam01083 1206780009770 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1206780009771 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1206780009772 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1206780009773 active site 1206780009774 dimerization interface 3.5A [polypeptide binding]; other site 1206780009775 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1206780009776 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1206780009777 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1206780009778 alphaNTD - beta interaction site [polypeptide binding]; other site 1206780009779 alphaNTD homodimer interface [polypeptide binding]; other site 1206780009780 alphaNTD - beta' interaction site [polypeptide binding]; other site 1206780009781 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1206780009782 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1206780009783 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1206780009784 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1206780009785 RNA binding surface [nucleotide binding]; other site 1206780009786 30S ribosomal protein S11; Validated; Region: PRK05309 1206780009787 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1206780009788 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1206780009789 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1206780009790 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1206780009791 rRNA binding site [nucleotide binding]; other site 1206780009792 predicted 30S ribosome binding site; other site 1206780009793 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1206780009794 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1206780009795 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1206780009796 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1206780009797 NAD binding site [chemical binding]; other site 1206780009798 substrate binding site [chemical binding]; other site 1206780009799 homodimer interface [polypeptide binding]; other site 1206780009800 active site 1206780009801 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1206780009802 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780009803 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780009804 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780009805 active site 1206780009806 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1206780009807 extended (e) SDRs; Region: SDR_e; cd08946 1206780009808 NAD(P) binding site [chemical binding]; other site 1206780009809 active site 1206780009810 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1206780009811 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1206780009812 active site 1206780009813 catalytic residues [active] 1206780009814 metal binding site [ion binding]; metal-binding site 1206780009815 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1206780009816 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1206780009817 PYR/PP interface [polypeptide binding]; other site 1206780009818 dimer interface [polypeptide binding]; other site 1206780009819 TPP binding site [chemical binding]; other site 1206780009820 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1206780009821 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1206780009822 TPP-binding site [chemical binding]; other site 1206780009823 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1206780009824 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1206780009825 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206780009826 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1206780009827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780009828 metabolite-proton symporter; Region: 2A0106; TIGR00883 1206780009829 putative substrate translocation pore; other site 1206780009830 PE family; Region: PE; pfam00934 1206780009831 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009832 PPE family; Region: PPE; pfam00823 1206780009833 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780009834 patatin-related protein; Region: TIGR03607 1206780009835 Protein of unknown function (DUF3376); Region: DUF3376; pfam11856 1206780009836 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1206780009837 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1206780009838 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1206780009839 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1206780009840 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1206780009841 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1206780009842 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1206780009843 short chain dehydrogenase; Provisional; Region: PRK05875 1206780009844 classical (c) SDRs; Region: SDR_c; cd05233 1206780009845 NAD(P) binding site [chemical binding]; other site 1206780009846 active site 1206780009847 Predicted membrane protein [Function unknown]; Region: COG2259 1206780009848 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1206780009849 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1206780009850 Predicted transcriptional regulators [Transcription]; Region: COG1695 1206780009851 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1206780009852 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1206780009853 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1206780009854 active site 1206780009855 homotetramer interface [polypeptide binding]; other site 1206780009856 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780009857 mce related protein; Region: MCE; pfam02470 1206780009858 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780009859 mce related protein; Region: MCE; pfam02470 1206780009860 mce related protein; Region: MCE; pfam02470 1206780009861 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780009862 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1206780009863 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780009864 mce related protein; Region: MCE; pfam02470 1206780009865 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780009866 mce related protein; Region: MCE; pfam02470 1206780009867 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1206780009868 mce related protein; Region: MCE; pfam02470 1206780009869 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1206780009870 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1206780009871 Permease; Region: Permease; pfam02405 1206780009872 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1206780009873 Permease; Region: Permease; pfam02405 1206780009874 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1206780009875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780009876 NAD(P) binding site [chemical binding]; other site 1206780009877 active site 1206780009878 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1206780009879 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1206780009880 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780009881 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1206780009882 FAD binding site [chemical binding]; other site 1206780009883 substrate binding site [chemical binding]; other site 1206780009884 catalytic base [active] 1206780009885 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780009886 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780009887 active site 1206780009888 acyl-CoA synthetase; Validated; Region: PRK07867 1206780009889 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1206780009890 acyl-activating enzyme (AAE) consensus motif; other site 1206780009891 putative AMP binding site [chemical binding]; other site 1206780009892 putative active site [active] 1206780009893 putative CoA binding site [chemical binding]; other site 1206780009894 PE family; Region: PE; pfam00934 1206780009895 PE family; Region: PE; pfam00934 1206780009896 hypothetical protein; Validated; Region: PRK07586 1206780009897 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1206780009898 PYR/PP interface [polypeptide binding]; other site 1206780009899 dimer interface [polypeptide binding]; other site 1206780009900 TPP binding site [chemical binding]; other site 1206780009901 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1206780009902 TPP-binding site [chemical binding]; other site 1206780009903 dimer interface [polypeptide binding]; other site 1206780009904 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1206780009905 PE family; Region: PE; pfam00934 1206780009906 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780009907 CoA binding site [chemical binding]; other site 1206780009908 PE family; Region: PE; pfam00934 1206780009909 acyl-CoA synthetase; Validated; Region: PRK07798 1206780009910 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780009911 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1206780009912 acyl-activating enzyme (AAE) consensus motif; other site 1206780009913 acyl-activating enzyme (AAE) consensus motif; other site 1206780009914 putative AMP binding site [chemical binding]; other site 1206780009915 putative active site [active] 1206780009916 putative CoA binding site [chemical binding]; other site 1206780009917 enoyl-CoA hydratase; Provisional; Region: PRK07799 1206780009918 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780009919 substrate binding site [chemical binding]; other site 1206780009920 oxyanion hole (OAH) forming residues; other site 1206780009921 trimer interface [polypeptide binding]; other site 1206780009922 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1206780009923 Cytochrome P450; Region: p450; cl12078 1206780009924 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780009925 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780009926 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1206780009927 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1206780009928 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1206780009929 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1206780009930 DUF35 OB-fold domain; Region: DUF35; pfam01796 1206780009931 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1206780009932 DUF35 OB-fold domain; Region: DUF35; pfam01796 1206780009933 lipid-transfer protein; Provisional; Region: PRK07937 1206780009934 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1206780009935 active site 1206780009936 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1206780009937 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1206780009938 active site 1206780009939 NHL repeat; Region: NHL; pfam01436 1206780009940 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1206780009941 NHL repeat; Region: NHL; pfam01436 1206780009942 NHL repeat; Region: NHL; pfam01436 1206780009943 NHL repeat; Region: NHL; pfam01436 1206780009944 NHL repeat; Region: NHL; pfam01436 1206780009945 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1206780009946 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1206780009947 trimer interface [polypeptide binding]; other site 1206780009948 putative metal binding site [ion binding]; other site 1206780009949 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1206780009950 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1206780009951 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1206780009952 short chain dehydrogenase; Provisional; Region: PRK07890 1206780009953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780009954 NAD(P) binding site [chemical binding]; other site 1206780009955 active site 1206780009956 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009957 PPE family; Region: PPE; pfam00823 1206780009958 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1206780009959 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009960 PPE family; Region: PPE; pfam00823 1206780009961 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009962 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1206780009963 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1206780009964 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1206780009965 active site 1206780009966 catalytic residues [active] 1206780009967 metal binding site [ion binding]; metal-binding site 1206780009968 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1206780009969 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1206780009970 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1206780009971 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1206780009972 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1206780009973 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1206780009974 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1206780009975 enoyl-CoA hydratase; Region: PLN02864 1206780009976 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1206780009977 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1206780009978 dimer interaction site [polypeptide binding]; other site 1206780009979 substrate-binding tunnel; other site 1206780009980 active site 1206780009981 catalytic site [active] 1206780009982 substrate binding site [chemical binding]; other site 1206780009983 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780009984 PPE family; Region: PPE; pfam00823 1206780009985 PE-PPE domain; Region: PE-PPE; pfam08237 1206780009986 lipid-transfer protein; Provisional; Region: PRK07855 1206780009987 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1206780009988 active site 1206780009989 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1206780009990 putative active site [active] 1206780009991 putative catalytic site [active] 1206780009992 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1206780009993 active site 1206780009994 catalytic site [active] 1206780009995 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1206780009996 DUF35 OB-fold domain; Region: DUF35; pfam01796 1206780009997 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780009998 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780009999 active site 1206780010000 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780010001 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1206780010002 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780010003 active site 1206780010004 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780010005 Cytochrome P450; Region: p450; cl12078 1206780010006 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1206780010007 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1206780010008 dimer interface [polypeptide binding]; other site 1206780010009 active site 1206780010010 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1206780010011 short chain dehydrogenase; Provisional; Region: PRK07791 1206780010012 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1206780010013 homodimer interface [polypeptide binding]; other site 1206780010014 NAD binding site [chemical binding]; other site 1206780010015 active site 1206780010016 short chain dehydrogenase; Provisional; Region: PRK07856 1206780010017 classical (c) SDRs; Region: SDR_c; cd05233 1206780010018 NAD(P) binding site [chemical binding]; other site 1206780010019 active site 1206780010020 enoyl-CoA hydratase; Provisional; Region: PRK06495 1206780010021 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780010022 substrate binding site [chemical binding]; other site 1206780010023 oxyanion hole (OAH) forming residues; other site 1206780010024 trimer interface [polypeptide binding]; other site 1206780010025 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1206780010026 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1206780010027 Nitronate monooxygenase; Region: NMO; pfam03060 1206780010028 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1206780010029 FMN binding site [chemical binding]; other site 1206780010030 substrate binding site [chemical binding]; other site 1206780010031 putative catalytic residue [active] 1206780010032 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1206780010033 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 1206780010034 putative di-iron ligands [ion binding]; other site 1206780010035 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1206780010036 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1206780010037 FAD binding pocket [chemical binding]; other site 1206780010038 FAD binding motif [chemical binding]; other site 1206780010039 phosphate binding motif [ion binding]; other site 1206780010040 beta-alpha-beta structure motif; other site 1206780010041 NAD(p) ribose binding residues [chemical binding]; other site 1206780010042 NAD binding pocket [chemical binding]; other site 1206780010043 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1206780010044 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1206780010045 catalytic loop [active] 1206780010046 iron binding site [ion binding]; other site 1206780010047 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1206780010048 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1206780010049 putative active site [active] 1206780010050 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1206780010051 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1206780010052 dimer interface [polypeptide binding]; other site 1206780010053 active site 1206780010054 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780010055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780010056 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1206780010057 PPE family; Region: PPE; pfam00823 1206780010058 short chain dehydrogenase; Provisional; Region: PRK07831 1206780010059 classical (c) SDRs; Region: SDR_c; cd05233 1206780010060 NAD(P) binding site [chemical binding]; other site 1206780010061 active site 1206780010062 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780010063 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780010064 active site 1206780010065 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1206780010066 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1206780010067 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1206780010068 acyl-activating enzyme (AAE) consensus motif; other site 1206780010069 putative AMP binding site [chemical binding]; other site 1206780010070 putative active site [active] 1206780010071 putative CoA binding site [chemical binding]; other site 1206780010072 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780010073 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780010074 active site 1206780010075 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780010076 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1206780010077 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780010078 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780010079 active site 1206780010080 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780010081 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1206780010082 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780010083 active site 1206780010084 aspartate aminotransferase; Provisional; Region: PRK05764 1206780010085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206780010086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780010087 homodimer interface [polypeptide binding]; other site 1206780010088 catalytic residue [active] 1206780010089 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1206780010090 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1206780010091 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1206780010092 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1206780010093 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1206780010094 active site 1206780010095 Fe binding site [ion binding]; other site 1206780010096 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1206780010097 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780010098 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1206780010099 Flavin binding site [chemical binding]; other site 1206780010100 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1206780010101 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1206780010102 FAD binding pocket [chemical binding]; other site 1206780010103 FAD binding motif [chemical binding]; other site 1206780010104 phosphate binding motif [ion binding]; other site 1206780010105 beta-alpha-beta structure motif; other site 1206780010106 NAD(p) ribose binding residues [chemical binding]; other site 1206780010107 NAD binding pocket [chemical binding]; other site 1206780010108 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1206780010109 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1206780010110 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1206780010111 catalytic loop [active] 1206780010112 iron binding site [ion binding]; other site 1206780010113 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780010114 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780010115 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1206780010116 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780010117 active site 1206780010118 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780010119 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780010120 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1206780010121 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1206780010122 DNA binding site [nucleotide binding] 1206780010123 domain linker motif; other site 1206780010124 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1206780010125 putative dimerization interface [polypeptide binding]; other site 1206780010126 putative ligand binding site [chemical binding]; other site 1206780010127 PknH-like extracellular domain; Region: PknH_C; pfam14032 1206780010128 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1206780010129 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1206780010130 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1206780010131 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1206780010132 transmembrane helices; other site 1206780010133 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1206780010134 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1206780010135 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1206780010136 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1206780010137 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1206780010138 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1206780010139 active site 1206780010140 HIGH motif; other site 1206780010141 nucleotide binding site [chemical binding]; other site 1206780010142 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1206780010143 KMSKS motif; other site 1206780010144 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1206780010145 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1206780010146 homotrimer interaction site [polypeptide binding]; other site 1206780010147 zinc binding site [ion binding]; other site 1206780010148 CDP-binding sites; other site 1206780010149 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1206780010150 substrate binding site; other site 1206780010151 dimer interface; other site 1206780010152 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1206780010153 DNA repair protein RadA; Provisional; Region: PRK11823 1206780010154 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1206780010155 Walker A motif/ATP binding site; other site 1206780010156 ATP binding site [chemical binding]; other site 1206780010157 Walker B motif; other site 1206780010158 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1206780010159 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1206780010160 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1206780010161 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1206780010162 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1206780010163 active site clefts [active] 1206780010164 zinc binding site [ion binding]; other site 1206780010165 dimer interface [polypeptide binding]; other site 1206780010166 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1206780010167 endonuclease III; Region: ENDO3c; smart00478 1206780010168 minor groove reading motif; other site 1206780010169 helix-hairpin-helix signature motif; other site 1206780010170 substrate binding pocket [chemical binding]; other site 1206780010171 active site 1206780010172 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1206780010173 PE family; Region: PE; pfam00934 1206780010174 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206780010175 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1206780010176 catalytic site [active] 1206780010177 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1206780010178 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1206780010179 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1206780010180 Ami_2 domain; Region: Ami_2; smart00644 1206780010181 amidase catalytic site [active] 1206780010182 Zn binding residues [ion binding]; other site 1206780010183 substrate binding site [chemical binding]; other site 1206780010184 PE family; Region: PE; pfam00934 1206780010185 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1206780010186 Clp amino terminal domain; Region: Clp_N; pfam02861 1206780010187 Clp amino terminal domain; Region: Clp_N; pfam02861 1206780010188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780010189 Walker A motif; other site 1206780010190 ATP binding site [chemical binding]; other site 1206780010191 Walker B motif; other site 1206780010192 arginine finger; other site 1206780010193 UvrB/uvrC motif; Region: UVR; pfam02151 1206780010194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780010195 Walker A motif; other site 1206780010196 ATP binding site [chemical binding]; other site 1206780010197 Walker B motif; other site 1206780010198 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1206780010199 Lsr2; Region: Lsr2; pfam11774 1206780010200 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1206780010201 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1206780010202 dimer interface [polypeptide binding]; other site 1206780010203 putative anticodon binding site; other site 1206780010204 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1206780010205 motif 1; other site 1206780010206 dimer interface [polypeptide binding]; other site 1206780010207 active site 1206780010208 motif 2; other site 1206780010209 motif 3; other site 1206780010210 pantothenate kinase; Reviewed; Region: PRK13318 1206780010211 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1206780010212 tetramerization interface [polypeptide binding]; other site 1206780010213 active site 1206780010214 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1206780010215 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1206780010216 active site 1206780010217 ATP-binding site [chemical binding]; other site 1206780010218 pantoate-binding site; other site 1206780010219 HXXH motif; other site 1206780010220 Rossmann-like domain; Region: Rossmann-like; pfam10727 1206780010221 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1206780010222 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1206780010223 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1206780010224 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1206780010225 catalytic center binding site [active] 1206780010226 ATP binding site [chemical binding]; other site 1206780010227 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1206780010228 homooctamer interface [polypeptide binding]; other site 1206780010229 active site 1206780010230 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1206780010231 dihydropteroate synthase; Region: DHPS; TIGR01496 1206780010232 substrate binding pocket [chemical binding]; other site 1206780010233 dimer interface [polypeptide binding]; other site 1206780010234 inhibitor binding site; inhibition site 1206780010235 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1206780010236 homodecamer interface [polypeptide binding]; other site 1206780010237 GTP cyclohydrolase I; Provisional; Region: PLN03044 1206780010238 active site 1206780010239 putative catalytic site residues [active] 1206780010240 zinc binding site [ion binding]; other site 1206780010241 GTP-CH-I/GFRP interaction surface; other site 1206780010242 FtsH Extracellular; Region: FtsH_ext; pfam06480 1206780010243 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1206780010244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780010245 Walker A motif; other site 1206780010246 ATP binding site [chemical binding]; other site 1206780010247 Walker B motif; other site 1206780010248 arginine finger; other site 1206780010249 Peptidase family M41; Region: Peptidase_M41; pfam01434 1206780010250 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1206780010251 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1206780010252 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1206780010253 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1206780010254 active site 1206780010255 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1206780010256 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1206780010257 Ligand Binding Site [chemical binding]; other site 1206780010258 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1206780010259 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1206780010260 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1206780010261 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1206780010262 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1206780010263 dimer interface [polypeptide binding]; other site 1206780010264 substrate binding site [chemical binding]; other site 1206780010265 metal binding sites [ion binding]; metal-binding site 1206780010266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 1206780010267 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1206780010268 Ligand binding site; other site 1206780010269 Putative Catalytic site; other site 1206780010270 DXD motif; other site 1206780010271 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1206780010272 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1206780010273 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1206780010274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780010275 NAD(P) binding site [chemical binding]; other site 1206780010276 active site 1206780010277 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1206780010278 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1206780010279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1206780010280 transposase; Provisional; Region: PRK06526 1206780010281 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 1206780010282 Walker B motif; other site 1206780010283 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1206780010284 MULE transposase domain; Region: MULE; pfam10551 1206780010285 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1206780010286 Fic/DOC family; Region: Fic; cl00960 1206780010287 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1206780010288 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1206780010289 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1206780010290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1206780010291 dimerization interface [polypeptide binding]; other site 1206780010292 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1206780010293 cyclase homology domain; Region: CHD; cd07302 1206780010294 nucleotidyl binding site; other site 1206780010295 metal binding site [ion binding]; metal-binding site 1206780010296 dimer interface [polypeptide binding]; other site 1206780010297 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1206780010298 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1206780010299 active site 1206780010300 interdomain interaction site; other site 1206780010301 putative metal-binding site [ion binding]; other site 1206780010302 nucleotide binding site [chemical binding]; other site 1206780010303 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1206780010304 domain I; other site 1206780010305 phosphate binding site [ion binding]; other site 1206780010306 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1206780010307 domain II; other site 1206780010308 domain III; other site 1206780010309 nucleotide binding site [chemical binding]; other site 1206780010310 DNA binding groove [nucleotide binding] 1206780010311 catalytic site [active] 1206780010312 domain IV; other site 1206780010313 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1206780010314 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1206780010315 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1206780010316 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1206780010317 DNA-binding site [nucleotide binding]; DNA binding site 1206780010318 RNA-binding motif; other site 1206780010319 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1206780010320 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1206780010321 ATP binding site [chemical binding]; other site 1206780010322 putative Mg++ binding site [ion binding]; other site 1206780010323 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1206780010324 nucleotide binding region [chemical binding]; other site 1206780010325 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1206780010326 PE family; Region: PE; pfam00934 1206780010327 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1206780010328 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1206780010329 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1206780010330 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1206780010331 Walker A motif; other site 1206780010332 ATP binding site [chemical binding]; other site 1206780010333 Walker B motif; other site 1206780010334 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1206780010335 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1206780010336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206780010337 motif II; other site 1206780010338 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1206780010339 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1206780010340 Walker A/P-loop; other site 1206780010341 ATP binding site [chemical binding]; other site 1206780010342 Q-loop/lid; other site 1206780010343 ABC transporter signature motif; other site 1206780010344 Walker B; other site 1206780010345 D-loop; other site 1206780010346 H-loop/switch region; other site 1206780010347 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1206780010348 Walker A/P-loop; other site 1206780010349 ATP binding site [chemical binding]; other site 1206780010350 Q-loop/lid; other site 1206780010351 ABC transporter signature motif; other site 1206780010352 Walker B; other site 1206780010353 D-loop; other site 1206780010354 H-loop/switch region; other site 1206780010355 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1206780010356 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1206780010357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780010358 ABC-ATPase subunit interface; other site 1206780010359 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1206780010360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780010361 dimer interface [polypeptide binding]; other site 1206780010362 conserved gate region; other site 1206780010363 ABC-ATPase subunit interface; other site 1206780010364 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1206780010365 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1206780010366 acetyl-CoA synthetase; Provisional; Region: PRK00174 1206780010367 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1206780010368 active site 1206780010369 CoA binding site [chemical binding]; other site 1206780010370 acyl-activating enzyme (AAE) consensus motif; other site 1206780010371 AMP binding site [chemical binding]; other site 1206780010372 acetate binding site [chemical binding]; other site 1206780010373 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1206780010374 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1206780010375 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1206780010376 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1206780010377 putative active site [active] 1206780010378 putative CoA binding site [chemical binding]; other site 1206780010379 nudix motif; other site 1206780010380 metal binding site [ion binding]; metal-binding site 1206780010381 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1206780010382 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1206780010383 catalytic residues [active] 1206780010384 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1206780010385 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1206780010386 minor groove reading motif; other site 1206780010387 helix-hairpin-helix signature motif; other site 1206780010388 substrate binding pocket [chemical binding]; other site 1206780010389 active site 1206780010390 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1206780010391 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1206780010392 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1206780010393 ligand binding site [chemical binding]; other site 1206780010394 flexible hinge region; other site 1206780010395 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1206780010396 putative switch regulator; other site 1206780010397 non-specific DNA interactions [nucleotide binding]; other site 1206780010398 DNA binding site [nucleotide binding] 1206780010399 sequence specific DNA binding site [nucleotide binding]; other site 1206780010400 putative cAMP binding site [chemical binding]; other site 1206780010401 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1206780010402 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1206780010403 homotrimer interaction site [polypeptide binding]; other site 1206780010404 putative active site [active] 1206780010405 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1206780010406 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1206780010407 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1206780010408 P loop; other site 1206780010409 Nucleotide binding site [chemical binding]; other site 1206780010410 DTAP/Switch II; other site 1206780010411 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1206780010412 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1206780010413 DTAP/Switch II; other site 1206780010414 Switch I; other site 1206780010415 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1206780010416 Transcription factor WhiB; Region: Whib; pfam02467 1206780010417 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1206780010418 Transglycosylase; Region: Transgly; pfam00912 1206780010419 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1206780010420 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1206780010421 phosphodiesterase YaeI; Provisional; Region: PRK11340 1206780010422 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1206780010423 putative active site [active] 1206780010424 putative metal binding site [ion binding]; other site 1206780010425 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1206780010426 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1206780010427 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206780010428 catalytic residue [active] 1206780010429 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1206780010430 Cytochrome P450; Region: p450; cl12078 1206780010431 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1206780010432 anti sigma factor interaction site; other site 1206780010433 regulatory phosphorylation site [posttranslational modification]; other site 1206780010434 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1206780010435 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1206780010436 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1206780010437 MoxR-like ATPases [General function prediction only]; Region: COG0714 1206780010438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780010439 Walker A motif; other site 1206780010440 ATP binding site [chemical binding]; other site 1206780010441 Walker B motif; other site 1206780010442 arginine finger; other site 1206780010443 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1206780010444 Protein of unknown function DUF58; Region: DUF58; pfam01882 1206780010445 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1206780010446 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1206780010447 glycerol kinase; Provisional; Region: glpK; PRK00047 1206780010448 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1206780010449 nucleotide binding site [chemical binding]; other site 1206780010450 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1206780010451 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1206780010452 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1206780010453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780010454 S-adenosylmethionine binding site [chemical binding]; other site 1206780010455 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1206780010456 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1206780010457 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206780010458 catalytic residue [active] 1206780010459 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1206780010460 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1206780010461 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1206780010462 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1206780010463 putative active site [active] 1206780010464 putative dimer interface [polypeptide binding]; other site 1206780010465 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1206780010466 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1206780010467 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 1206780010468 PknH-like extracellular domain; Region: PknH_C; pfam14032 1206780010469 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1206780010470 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1206780010471 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1206780010472 aspartate kinase; Reviewed; Region: PRK06635 1206780010473 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1206780010474 putative nucleotide binding site [chemical binding]; other site 1206780010475 putative catalytic residues [active] 1206780010476 putative Mg ion binding site [ion binding]; other site 1206780010477 putative aspartate binding site [chemical binding]; other site 1206780010478 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1206780010479 putative allosteric regulatory site; other site 1206780010480 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1206780010481 putative allosteric regulatory residue; other site 1206780010482 2-isopropylmalate synthase; Validated; Region: PRK03739 1206780010483 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1206780010484 active site 1206780010485 catalytic residues [active] 1206780010486 metal binding site [ion binding]; metal-binding site 1206780010487 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1206780010488 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1206780010489 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1206780010490 active site 1206780010491 catalytic site [active] 1206780010492 substrate binding site [chemical binding]; other site 1206780010493 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1206780010494 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1206780010495 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1206780010496 catalytic triad [active] 1206780010497 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1206780010498 putative active site [active] 1206780010499 recombination protein RecR; Reviewed; Region: recR; PRK00076 1206780010500 RecR protein; Region: RecR; pfam02132 1206780010501 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1206780010502 putative active site [active] 1206780010503 putative metal-binding site [ion binding]; other site 1206780010504 tetramer interface [polypeptide binding]; other site 1206780010505 hypothetical protein; Validated; Region: PRK00153 1206780010506 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1206780010507 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1206780010508 active site 1206780010509 metal binding site [ion binding]; metal-binding site 1206780010510 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1206780010511 hydrophobic ligand binding site; other site 1206780010512 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1206780010513 FAD binding domain; Region: FAD_binding_4; pfam01565 1206780010514 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1206780010515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780010516 S-adenosylmethionine binding site [chemical binding]; other site 1206780010517 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 1206780010518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780010519 Walker A motif; other site 1206780010520 ATP binding site [chemical binding]; other site 1206780010521 Walker B motif; other site 1206780010522 arginine finger; other site 1206780010523 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1206780010524 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1206780010525 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1206780010526 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206780010527 catalytic residue [active] 1206780010528 Cutinase; Region: Cutinase; pfam01083 1206780010529 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1206780010530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780010531 NAD(P) binding site [chemical binding]; other site 1206780010532 active site 1206780010533 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1206780010534 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1206780010535 putative NAD(P) binding site [chemical binding]; other site 1206780010536 catalytic Zn binding site [ion binding]; other site 1206780010537 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1206780010538 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1206780010539 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1206780010540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1206780010541 putative substrate translocation pore; other site 1206780010542 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1206780010543 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1206780010544 ligand binding site [chemical binding]; other site 1206780010545 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1206780010546 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1206780010547 active site 1206780010548 nucleophile elbow; other site 1206780010549 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 1206780010550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1206780010551 FeS/SAM binding site; other site 1206780010552 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1206780010553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780010554 S-adenosylmethionine binding site [chemical binding]; other site 1206780010555 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1206780010556 nucleotide binding site [chemical binding]; other site 1206780010557 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1206780010558 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1206780010559 active site 1206780010560 DNA binding site [nucleotide binding] 1206780010561 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1206780010562 DNA binding site [nucleotide binding] 1206780010563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 1206780010564 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 1206780010565 nudix motif; other site 1206780010566 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1206780010567 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1206780010568 Uncharacterized conserved protein [Function unknown]; Region: COG1839 1206780010569 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1206780010570 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1206780010571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206780010572 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1206780010573 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1206780010574 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1206780010575 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1206780010576 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1206780010577 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1206780010578 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1206780010579 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1206780010580 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1206780010581 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1206780010582 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1206780010583 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1206780010584 dimerization interface [polypeptide binding]; other site 1206780010585 putative DNA binding site [nucleotide binding]; other site 1206780010586 putative Zn2+ binding site [ion binding]; other site 1206780010587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 1206780010588 DNA binding domain, excisionase family; Region: excise; TIGR01764 1206780010589 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1206780010590 active site 1206780010591 Int/Topo IB signature motif; other site 1206780010592 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1206780010593 nucleoside/Zn binding site; other site 1206780010594 dimer interface [polypeptide binding]; other site 1206780010595 catalytic motif [active] 1206780010596 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1206780010597 prephenate dehydrogenase; Validated; Region: PRK06545 1206780010598 prephenate dehydrogenase; Validated; Region: PRK08507 1206780010599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 1206780010600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1206780010601 ABC-ATPase subunit interface; other site 1206780010602 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1206780010603 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1206780010604 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1206780010605 Walker A/P-loop; other site 1206780010606 ATP binding site [chemical binding]; other site 1206780010607 Q-loop/lid; other site 1206780010608 ABC transporter signature motif; other site 1206780010609 Walker B; other site 1206780010610 D-loop; other site 1206780010611 H-loop/switch region; other site 1206780010612 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1206780010613 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1206780010614 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1206780010615 putative active site [active] 1206780010616 putative substrate binding site [chemical binding]; other site 1206780010617 ATP binding site [chemical binding]; other site 1206780010618 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1206780010619 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1206780010620 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1206780010621 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1206780010622 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1206780010623 dimerization interface [polypeptide binding]; other site 1206780010624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1206780010625 dimer interface [polypeptide binding]; other site 1206780010626 phosphorylation site [posttranslational modification] 1206780010627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1206780010628 ATP binding site [chemical binding]; other site 1206780010629 Mg2+ binding site [ion binding]; other site 1206780010630 G-X-G motif; other site 1206780010631 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1206780010632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1206780010633 active site 1206780010634 phosphorylation site [posttranslational modification] 1206780010635 intermolecular recognition site; other site 1206780010636 dimerization interface [polypeptide binding]; other site 1206780010637 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1206780010638 DNA binding site [nucleotide binding] 1206780010639 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1206780010640 active site 1206780010641 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1206780010642 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1206780010643 SnoaL-like domain; Region: SnoaL_2; pfam12680 1206780010644 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1206780010645 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1206780010646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1206780010647 homodimer interface [polypeptide binding]; other site 1206780010648 catalytic residue [active] 1206780010649 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1206780010650 TIGR03086 family protein; Region: TIGR03086 1206780010651 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1206780010652 enoyl-CoA hydratase; Provisional; Region: PRK06142 1206780010653 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1206780010654 substrate binding site [chemical binding]; other site 1206780010655 oxyanion hole (OAH) forming residues; other site 1206780010656 trimer interface [polypeptide binding]; other site 1206780010657 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1206780010658 Beta-lactamase; Region: Beta-lactamase; pfam00144 1206780010659 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1206780010660 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1206780010661 active site 1206780010662 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1206780010663 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1206780010664 NAD(P) binding site [chemical binding]; other site 1206780010665 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1206780010666 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 1206780010667 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1206780010668 catalytic residue [active] 1206780010669 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1206780010670 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1206780010671 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1206780010672 Walker A/P-loop; other site 1206780010673 ATP binding site [chemical binding]; other site 1206780010674 Q-loop/lid; other site 1206780010675 ABC transporter signature motif; other site 1206780010676 Walker B; other site 1206780010677 D-loop; other site 1206780010678 H-loop/switch region; other site 1206780010679 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1206780010680 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206780010681 active site 1206780010682 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1206780010683 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1206780010684 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1206780010685 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1206780010686 NAD binding site [chemical binding]; other site 1206780010687 substrate binding site [chemical binding]; other site 1206780010688 active site 1206780010689 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1206780010690 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206780010691 active site 1206780010692 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1206780010693 Peptidase family M23; Region: Peptidase_M23; pfam01551 1206780010694 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1206780010695 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1206780010696 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1206780010697 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1206780010698 Predicted membrane protein [Function unknown]; Region: COG2246 1206780010699 GtrA-like protein; Region: GtrA; pfam04138 1206780010700 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1206780010701 FAD binding domain; Region: FAD_binding_4; pfam01565 1206780010702 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1206780010703 short chain dehydrogenase; Provisional; Region: PRK07904 1206780010704 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1206780010705 NAD(P) binding site [chemical binding]; other site 1206780010706 active site 1206780010707 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1206780010708 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1206780010709 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1206780010710 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1206780010711 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1206780010712 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1206780010713 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1206780010714 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1206780010715 FAD binding site [chemical binding]; other site 1206780010716 substrate binding site [chemical binding]; other site 1206780010717 catalytic residues [active] 1206780010718 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1206780010719 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1206780010720 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1206780010721 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1206780010722 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1206780010723 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780010724 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780010725 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1206780010726 active site 1206780010727 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1206780010728 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1206780010729 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780010730 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1206780010731 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1206780010732 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1206780010733 acyl-activating enzyme (AAE) consensus motif; other site 1206780010734 active site 1206780010735 Cutinase; Region: Cutinase; pfam01083 1206780010736 Predicted esterase [General function prediction only]; Region: COG0627 1206780010737 Putative esterase; Region: Esterase; pfam00756 1206780010738 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1206780010739 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1206780010740 active site 1206780010741 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1206780010742 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1206780010743 active site 1206780010744 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1206780010745 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1206780010746 UDP-galactopyranose mutase; Region: GLF; pfam03275 1206780010747 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1206780010748 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1206780010749 amidase catalytic site [active] 1206780010750 Zn binding residues [ion binding]; other site 1206780010751 substrate binding site [chemical binding]; other site 1206780010752 LGFP repeat; Region: LGFP; pfam08310 1206780010753 PE family; Region: PE; pfam00934 1206780010754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1206780010755 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1206780010756 active site 1206780010757 motif I; other site 1206780010758 motif II; other site 1206780010759 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1206780010760 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1206780010761 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1206780010762 putative acyl-acceptor binding pocket; other site 1206780010763 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1206780010764 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1206780010765 putative acyl-acceptor binding pocket; other site 1206780010766 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1206780010767 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1206780010768 putative acyl-acceptor binding pocket; other site 1206780010769 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1206780010770 Phosphotransferase enzyme family; Region: APH; pfam01636 1206780010771 active site 1206780010772 ATP binding site [chemical binding]; other site 1206780010773 antibiotic binding site [chemical binding]; other site 1206780010774 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1206780010775 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1206780010776 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1206780010777 iron-sulfur cluster [ion binding]; other site 1206780010778 [2Fe-2S] cluster binding site [ion binding]; other site 1206780010779 Condensation domain; Region: Condensation; pfam00668 1206780010780 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1206780010781 PE-PPE domain; Region: PE-PPE; pfam08237 1206780010782 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1206780010783 Condensation domain; Region: Condensation; pfam00668 1206780010784 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1206780010785 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1206780010786 active site 1206780010787 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1206780010788 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1206780010789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1206780010790 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1206780010791 Enoylreductase; Region: PKS_ER; smart00829 1206780010792 NAD(P) binding site [chemical binding]; other site 1206780010793 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1206780010794 KR domain; Region: KR; pfam08659 1206780010795 putative NADP binding site [chemical binding]; other site 1206780010796 active site 1206780010797 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1206780010798 acyl-CoA synthetase; Validated; Region: PRK05850 1206780010799 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1206780010800 acyl-activating enzyme (AAE) consensus motif; other site 1206780010801 active site 1206780010802 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1206780010803 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1206780010804 Probable transposase; Region: OrfB_IS605; pfam01385 1206780010805 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1206780010806 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1206780010807 catalytic residues [active] 1206780010808 catalytic nucleophile [active] 1206780010809 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1206780010810 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1206780010811 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1206780010812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780010813 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1206780010814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1206780010815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1206780010816 Cupin domain; Region: Cupin_2; cl17218 1206780010817 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1206780010818 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1206780010819 seryl-tRNA synthetase; Provisional; Region: PRK05431 1206780010820 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1206780010821 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1206780010822 dimer interface [polypeptide binding]; other site 1206780010823 active site 1206780010824 motif 1; other site 1206780010825 motif 2; other site 1206780010826 motif 3; other site 1206780010827 Septum formation; Region: Septum_form; pfam13845 1206780010828 Septum formation; Region: Septum_form; pfam13845 1206780010829 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1206780010830 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1206780010831 catalytic core [active] 1206780010832 prephenate dehydratase; Provisional; Region: PRK11898 1206780010833 Prephenate dehydratase; Region: PDT; pfam00800 1206780010834 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1206780010835 putative L-Phe binding site [chemical binding]; other site 1206780010836 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1206780010837 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1206780010838 Ferritin-like domain; Region: Ferritin; pfam00210 1206780010839 ferroxidase diiron center [ion binding]; other site 1206780010840 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1206780010841 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1206780010842 putative active site [active] 1206780010843 catalytic site [active] 1206780010844 putative metal binding site [ion binding]; other site 1206780010845 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1206780010846 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1206780010847 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1206780010848 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1206780010849 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1206780010850 Predicted membrane protein [Function unknown]; Region: COG2119 1206780010851 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1206780010852 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1206780010853 Fimbrial protein; Region: Fimbrial; cl01416 1206780010854 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1206780010855 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1206780010856 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1206780010857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1206780010858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1206780010859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1206780010860 hypothetical protein; Provisional; Region: PRK07945 1206780010861 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1206780010862 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1206780010863 active site 1206780010864 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1206780010865 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1206780010866 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1206780010867 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1206780010868 active site 1206780010869 dimer interface [polypeptide binding]; other site 1206780010870 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1206780010871 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1206780010872 active site 1206780010873 FMN binding site [chemical binding]; other site 1206780010874 substrate binding site [chemical binding]; other site 1206780010875 3Fe-4S cluster binding site [ion binding]; other site 1206780010876 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1206780010877 domain interface; other site 1206780010878 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1206780010879 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1206780010880 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1206780010881 EspG family; Region: ESX-1_EspG; pfam14011 1206780010882 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1206780010883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780010884 Walker A motif; other site 1206780010885 ATP binding site [chemical binding]; other site 1206780010886 Walker B motif; other site 1206780010887 arginine finger; other site 1206780010888 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1206780010889 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1206780010890 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206780010891 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206780010892 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206780010893 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1206780010894 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1206780010895 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1206780010896 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1206780010897 active site 1206780010898 catalytic residues [active] 1206780010899 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1206780010900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1206780010901 Walker A motif; other site 1206780010902 ATP binding site [chemical binding]; other site 1206780010903 Walker B motif; other site 1206780010904 arginine finger; other site 1206780010905 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1206780010906 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1206780010907 catalytic residues [active] 1206780010908 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1206780010909 active site 1206780010910 catalytic residues [active] 1206780010911 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1206780010912 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1206780010913 EspG family; Region: ESX-1_EspG; pfam14011 1206780010914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1206780010915 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1206780010916 PPE family; Region: PPE; pfam00823 1206780010917 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1206780010918 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206780010919 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206780010920 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1206780010921 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1206780010922 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1206780010923 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1206780010924 catalytic residue [active] 1206780010925 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1206780010926 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1206780010927 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1206780010928 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1206780010929 active site 1206780010930 NTP binding site [chemical binding]; other site 1206780010931 metal binding triad [ion binding]; metal-binding site 1206780010932 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1206780010933 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1206780010934 Zn2+ binding site [ion binding]; other site 1206780010935 Mg2+ binding site [ion binding]; other site 1206780010936 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1206780010937 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1206780010938 active site 1206780010939 Ap6A binding site [chemical binding]; other site 1206780010940 nudix motif; other site 1206780010941 metal binding site [ion binding]; metal-binding site 1206780010942 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1206780010943 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1206780010944 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1206780010945 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1206780010946 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1206780010947 DNA binding residues [nucleotide binding] 1206780010948 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1206780010949 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1206780010950 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1206780010951 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1206780010952 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1206780010953 catalytic residues [active] 1206780010954 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1206780010955 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1206780010956 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1206780010957 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1206780010958 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1206780010959 active site 1206780010960 metal binding site [ion binding]; metal-binding site 1206780010961 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1206780010962 ParB-like nuclease domain; Region: ParB; smart00470 1206780010963 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1206780010964 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206780010965 P-loop; other site 1206780010966 Magnesium ion binding site [ion binding]; other site 1206780010967 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1206780010968 Magnesium ion binding site [ion binding]; other site 1206780010969 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1206780010970 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1206780010971 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1206780010972 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1206780010973 G-X-X-G motif; other site 1206780010974 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1206780010975 RxxxH motif; other site 1206780010976 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1206780010977 Uncharacterized conserved protein [Function unknown]; Region: COG0759 1206780010978 ribonuclease P; Reviewed; Region: rnpA; PRK00588 1206780010979 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399