-- dump date 20140619_151525 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_976107.1 121635884 4697358 1..1524 1 NC_008769.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1524 dnaA 4697358 dnaA Mycobacterium bovis BCG str. Pasteur 1173P2 chromosomal replication initiation protein YP_976107.1 1 D 410289 CDS YP_976108.1 121635885 4697407 2052..3260 1 NC_008769.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 3260 dnaN_1 4697407 dnaN_1 Mycobacterium bovis BCG str. Pasteur 1173P2 DNA polymerase III subunit beta YP_976108.1 2052 D 410289 CDS YP_976109.1 121635886 4695679 3280..4437 1 NC_008769.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 4437 recF 4695679 recF Mycobacterium bovis BCG str. Pasteur 1173P2 recombination protein F YP_976109.1 3280 D 410289 CDS YP_976110.1 121635887 4696082 4434..4997 1 NC_008769.1 Differs from Mb0004 by 1aa, S16L; hypothetical protein 4997 4696082 BCG_0004 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976110.1 4434 D 410289 CDS YP_976111.1 121635888 4695574 5123..7267 1 NC_008769.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 7267 gyrB 4695574 gyrB Mycobacterium bovis BCG str. Pasteur 1173P2 DNA gyrase subunit B YP_976111.1 5123 D 410289 CDS YP_976112.1 121635889 4695442 7302..9818 1 NC_008769.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 9818 gyrA_1 4695442 gyrA_1 Mycobacterium bovis BCG str. Pasteur 1173P2 DNA gyrase subunit A YP_976112.1 7302 D 410289 CDS YP_976113.1 121635890 4695440 9914..10828 1 NC_008769.1 Differs from Rv0007 by 1aa, I272V; hypothetical protein 10828 4695440 BCG_0007 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976113.1 9914 D 410289 CDS YP_976114.1 121635891 4697331 complement(11874..12311) 1 NC_008769.1 Differs from Rv0008c by 1aa, P145S; hypothetical protein 12311 4697331 BCG_0008c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976114.1 11874 R 410289 CDS YP_976115.1 121635892 4697477 12468..13016 1 NC_008769.1 iron-regulated peptidyl-prolyl cis-trans isomerase A ppiA 13016 ppiA_1 4697477 ppiA_1 Mycobacterium bovis BCG str. Pasteur 1173P2 iron-regulated peptidyl-prolyl cis-trans isomerase A ppiA YP_976115.1 12468 D 410289 CDS YP_976116.1 121635893 4698099 complement(13222..13557) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (g-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (111 aa versus 141 aa); hypothetical protein 13557 4698099 BCG_0010c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976116.1 13222 R 410289 CDS YP_976117.1 121635894 4695508 complement(13713..13994) 1 NC_008769.1 integral membrane protein involved in inhibition of the Z-ring formation; septation inhibitor protein 13994 4695508 BCG_0011c Mycobacterium bovis BCG str. Pasteur 1173P2 septation inhibitor protein YP_976117.1 13713 R 410289 CDS YP_976118.1 121635895 4699131 14088..14876 1 NC_008769.1 Differs from Rv0012 by 2aa, E105K, R233C; hypothetical protein 14876 4699131 BCG_0012 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976118.1 14088 D 410289 CDS YP_976119.1 121635896 4698875 14913..15611 1 NC_008769.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 15611 trpG_1 4698875 trpG_1 Mycobacterium bovis BCG str. Pasteur 1173P2 para-aminobenzoate synthase component II YP_976119.1 14913 D 410289 CDS YP_976120.1 121635897 4696441 18322..18912 1 NC_008769.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase; RNA polymerase sigma factor SigM 18912 sigMa_2 4696441 sigMa_2 Mycobacterium bovis BCG str. Pasteur 1173P2 RNA polymerase sigma factor SigM YP_976120.1 18322 D 410289 CDS YP_976121.1 121635898 4697289 19005..19769 1 NC_008769.1 hypothetical protein 19769 4697289 BCG_0018 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976121.1 19005 D 410289 CDS YP_976122.1 121635899 4695650 19863..20870 1 NC_008769.1 Differs from Rv3913 by 1aa, G57D; thioredoxin reductase trxB2 (TRXR) 20870 trxB2_2 4695650 trxB2_2 Mycobacterium bovis BCG str. Pasteur 1173P2 thioredoxin reductase trxB2 (TRXR) YP_976122.1 19863 D 410289 CDS YP_976123.1 121635900 4696834 20867..21217 1 NC_008769.1 thioredoxin trxC (TRX) (MPT46) 21217 trxC_2 4696834 trxC_2 Mycobacterium bovis BCG str. Pasteur 1173P2 thioredoxin trxC (TRX) (MPT46) YP_976123.1 20867 D 410289 CDS YP_976124.1 121635901 4697088 21327..22547 1 NC_008769.1 hydrolase 22547 4697088 BCG_0021 Mycobacterium bovis BCG str. Pasteur 1173P2 hydrolase YP_976124.1 21327 D 410289 CDS YP_976125.1 121635902 4695702 complement(22568..23302) 1 NC_008769.1 hypothetical protein 23302 4695702 BCG_0022c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976125.1 22568 R 410289 CDS YP_976126.1 121635903 4695600 complement(23592..24626) 1 NC_008769.1 chromosome partitioning protein parB 24626 parB_2 4695600 parB_2 Mycobacterium bovis BCG str. Pasteur 1173P2 chromosome partitioning protein parB YP_976126.1 23592 R 410289 CDS YP_976127.1 121635904 4697551 complement(24623..25666) 1 NC_008769.1 chromosome partitioning protein parA 25666 parA_2 4697551 parA_2 Mycobacterium bovis BCG str. Pasteur 1173P2 chromosome partitioning protein parA YP_976127.1 24623 R 410289 CDS YP_976128.1 121635905 4697549 complement(25663..26337) 1 NC_008769.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 26337 gidB 4697549 gidB Mycobacterium bovis BCG str. Pasteur 1173P2 16S rRNA methyltransferase GidB YP_976128.1 25663 R 410289 CDS YP_976129.1 121635906 4697395 complement(26469..27032) 1 NC_008769.1 Differs from Rv3920c by 1aa, W110R; hypothetical protein 27032 4697395 BCG_0026c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976129.1 26469 R 410289 CDS YP_976130.1 121635907 4696493 complement(27104..28204) 1 NC_008769.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; preprotein translocase subunit YidC 28204 4696493 BCG_0027c Mycobacterium bovis BCG str. Pasteur 1173P2 preprotein translocase subunit YidC YP_976130.1 27104 R 410289 CDS YP_976131.1 121635908 4697744 complement(28188..28550) 1 NC_008769.1 hypothetical protein 28550 4697744 BCG_0028c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976131.1 28188 R 410289 CDS YP_976132.1 121635909 4697864 complement(28547..28924) 1 NC_008769.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 28924 rnpA 4697864 rnpA Mycobacterium bovis BCG str. Pasteur 1173P2 ribonuclease P YP_976132.1 28547 R 410289 CDS YP_976133.1 121635910 4696318 complement(28921..29064) 1 NC_008769.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 29064 rpmH 4696318 rpmH Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L34 YP_976133.1 28921 R 410289 CDS YP_976134.1 121635911 4695799 29668..31191 1 NC_008769.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 31191 dnaA 4695799 dnaA Mycobacterium bovis BCG str. Pasteur 1173P2 chromosomal replication initiation protein YP_976134.1 29668 D 410289 CDS YP_976135.1 121635912 4696807 31719..32927 1 NC_008769.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 32927 dnaN_2 4696807 dnaN_2 Mycobacterium bovis BCG str. Pasteur 1173P2 DNA polymerase III subunit beta YP_976135.1 31719 D 410289 CDS YP_976136.1 121635913 4697933 32947..34104 1 NC_008769.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 34104 recF 4697933 recF Mycobacterium bovis BCG str. Pasteur 1173P2 recombination protein F YP_976136.1 32947 D 410289 CDS YP_976137.1 121635914 4696083 34101..34664 1 NC_008769.1 Differs from Mb0004 by 1aa, S16L; hypothetical protein 34664 4696083 BCG_0034 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976137.1 34101 D 410289 CDS YP_976138.1 121635915 4696763 34790..36934 1 NC_008769.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 36934 gyrB 4696763 gyrB Mycobacterium bovis BCG str. Pasteur 1173P2 DNA gyrase subunit B YP_976138.1 34790 D 410289 CDS YP_976139.1 121635916 4695443 36969..39485 1 NC_008769.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 39485 gyrA_2 4695443 gyrA_2 Mycobacterium bovis BCG str. Pasteur 1173P2 DNA gyrase subunit A YP_976139.1 36969 D 410289 CDS YP_976140.1 121635917 4695441 39581..40495 1 NC_008769.1 Differs from Rv0007 by 1aa, I272V; hypothetical protein 40495 4695441 BCG_0037 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976140.1 39581 D 410289 CDS YP_976141.1 121635918 4697079 complement(41541..41978) 1 NC_008769.1 Differs from Rv0008c by 1aa, P145S; hypothetical protein 41978 4697079 BCG_0038c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976141.1 41541 R 410289 CDS YP_976142.1 121635919 4698839 42135..42683 1 NC_008769.1 iron-regulated peptidyl-prolyl cis-trans isomerase a ppiA 42683 ppiA_2 4698839 ppiA_2 Mycobacterium bovis BCG str. Pasteur 1173P2 iron-regulated peptidyl-prolyl cis-trans isomerase a ppiA YP_976142.1 42135 D 410289 CDS YP_976143.1 121635920 4698100 complement(42889..43224) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (g-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (111 aa versus 141 aa); hypothetical protein 43224 4698100 BCG_0040c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976143.1 42889 R 410289 CDS YP_976144.1 121635921 4695661 complement(43380..43661) 1 NC_008769.1 integral membrane protein involved in inhibition of the Z-ring formation; septation inhibitor protein 43661 4695661 BCG_0041c Mycobacterium bovis BCG str. Pasteur 1173P2 septation inhibitor protein YP_976144.1 43380 R 410289 CDS YP_976145.1 121635922 4698560 43755..44543 1 NC_008769.1 Differs from Rv0012 by 2aa, E105K, R233C; hypothetical protein 44543 4698560 BCG_0042 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976145.1 43755 D 410289 CDS YP_976146.1 121635923 4695708 44580..45278 1 NC_008769.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 45278 trpG_2 4695708 trpG_2 Mycobacterium bovis BCG str. Pasteur 1173P2 para-aminobenzoate synthase component II YP_976146.1 44580 D 410289 CDS YP_976147.1 121635924 4695829 complement(45256..47136) 1 NC_008769.1 Ser/Thr protein kinase 47136 pknB 4695829 pknB Mycobacterium bovis BCG str. Pasteur 1173P2 Ser/Thr protein kinase YP_976147.1 45256 R 410289 CDS YP_976148.1 121635925 4696549 complement(47133..48428) 1 NC_008769.1 Ser/Thr protein kinase 48428 pknA 4696549 pknA Mycobacterium bovis BCG str. Pasteur 1173P2 Ser/Thr protein kinase YP_976148.1 47133 R 410289 CDS YP_976149.1 121635926 4699308 complement(48425..49900) 1 NC_008769.1 penicillin-binding protein pbpA 49900 pbpA 4699308 pbpA Mycobacterium bovis BCG str. Pasteur 1173P2 penicillin-binding protein pbpA YP_976149.1 48425 R 410289 CDS YP_976150.1 121635927 4698833 complement(49897..51306) 1 NC_008769.1 cell division protein rodA 51306 rodA 4698833 rodA Mycobacterium bovis BCG str. Pasteur 1173P2 cell division protein rodA YP_976150.1 49897 R 410289 CDS YP_976151.1 121635928 4697710 complement(51303..52847) 1 NC_008769.1 Differs from Rv0018c by 3aa, L3R, A455S, S463P; Serine/threonine phosphatase PPP 52847 pstP 4697710 pstP Mycobacterium bovis BCG str. Pasteur 1173P2 Serine/threonine phosphatase PPP YP_976151.1 51303 R 410289 CDS YP_976152.1 121635929 4695696 complement(52936..53403) 1 NC_008769.1 hypothetical protein 53403 4695696 BCG_0049c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976152.1 52936 R 410289 CDS YP_976153.1 121635930 4697326 complement(53527..55092) 1 NC_008769.1 Differs from Mb0020c by 2aa, G47R, Y250H, and from Rv0020c by 3aa, G222D, C298Y, Q378R, and deletion of 6aa (EQRGYP) at position 246; hypothetical protein 55092 TB39.8 4697326 TB39.8 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976153.1 53527 R 410289 CDS YP_976154.1 121635931 4696748 complement(55561..56529) 1 NC_008769.1 Differs from Rv0021c by 1aa, P277A; hypothetical protein 56529 4696748 BCG_0051c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976154.1 55561 R 410289 CDS YP_976155.1 121635932 4698046 complement(56671..57090) 1 NC_008769.1 transcriptional regulatory protein whiB-like whiB5 57090 whiB5 4698046 whiB5 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein whiB-like whiB5 YP_976155.1 56671 R 410289 CDS YP_976156.1 121635933 4697344 57243..58013 1 NC_008769.1 transcriptional regulatory protein 58013 4697344 BCG_0053 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976156.1 57243 D 410289 CDS YP_976157.1 121635934 4697145 58010..58843 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, and other mycobacteria, Rv0024 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0024 into 2 parts; hypothetical protein 58843 4697145 BCG_0054 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976157.1 58010 D 410289 CDS YP_976158.1 121635935 4696316 58892..59254 1 NC_008769.1 Differs from Rv0025 by 1aa, L73P; hypothetical protein 59254 4696316 BCG_0056 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976158.1 58892 D 410289 CDS YP_976159.1 121635936 4695476 59369..60802 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 4 bp insertion (*-atcg) leads to a longer protein with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (477 aa versus 448 aa). Differs from Rv0026 by 1aa, P93Q; hypothetical protein 60802 4695476 BCG_0057 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976159.1 59369 D 410289 CDS YP_976160.1 121635937 4698607 60840..61157 1 NC_008769.1 hypothetical protein 61157 4698607 BCG_0058 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976160.1 60840 D 410289 CDS YP_976161.1 121635938 4695862 61165..61470 1 NC_008769.1 hypothetical protein 61470 4695862 BCG_0059 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976161.1 61165 D 410289 CDS YP_976162.1 121635939 4696897 61708..62805 1 NC_008769.1 Differs from Rv0029 by 1aa, N190H; hypothetical protein 62805 4696897 BCG_0060 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976162.1 61708 D 410289 CDS YP_976163.1 121635940 4695377 62875..63204 1 NC_008769.1 hypothetical protein 63204 4695377 BCG_0061 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976163.1 62875 D 410289 CDS YP_976164.1 121635941 4696701 63233..63445 1 NC_008769.1 remnant of a transposase 63445 4696701 BCG_0062 Mycobacterium bovis BCG str. Pasteur 1173P2 remnant of a transposase YP_976164.1 63233 D 410289 CDS YP_976165.1 121635942 4696691 63946..66261 1 NC_008769.1 8-amino-7-oxononanoate synthase bioF2 66261 bioF2 4696691 bioF2 Mycobacterium bovis BCG str. Pasteur 1173P2 8-amino-7-oxononanoate synthase bioF2 YP_976165.1 63946 D 410289 CDS YP_976166.1 121635943 4695544 66258..66521 1 NC_008769.1 acyl carrier protein 66521 acpA 4695544 acpA Mycobacterium bovis BCG str. Pasteur 1173P2 acyl carrier protein YP_976166.1 66258 D 410289 CDS YP_976167.1 121635944 4695773 66518..66913 1 NC_008769.1 hypothetical protein 66913 4695773 BCG_0065 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976167.1 66518 D 410289 CDS YP_976168.1 121635945 4697408 66910..68598 1 NC_008769.1 fatty-acid-CoA ligase 68598 fadD34 4697408 fadD34 Mycobacterium bovis BCG str. Pasteur 1173P2 fatty-acid-CoA ligase YP_976168.1 66910 D 410289 CDS YP_976169.1 121635946 4699133 complement(68799..69479) 1 NC_008769.1 Differs from Mb0037c and Rv0036c by 1aa, L186P, and at C-terminal end due to frameshift resulting from 1 bp deletion at position equivalent to Mycobacterium tuberculosis H37Rv2, 39228-39228, after codon 202; hypothetical protein 69479 4699133 BCG_0067c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976169.1 68799 R 410289 CDS YP_976170.1 121635947 4697953 complement(69527..70852) 1 NC_008769.1 integral membrane protein 70852 4697953 BCG_0068c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_976170.1 69527 R 410289 CDS YP_976171.1 121635948 4696034 70954..71562 1 NC_008769.1 hypothetical protein 71562 4696034 BCG_0069 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976171.1 70954 D 410289 CDS YP_976172.1 121635949 4699368 complement(71654..72001) 1 NC_008769.1 Differs from Rv0039c by 1aa, F24C; hypothetical protein 72001 4699368 BCG_0070c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976172.1 71654 R 410289 CDS YP_976173.1 121635950 4697254 complement(72083..73015) 1 NC_008769.1 hypothetical protein 73015 mtc28 4697254 mtc28 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976173.1 72083 R 410289 CDS YP_976174.1 121635951 4697737 73212..76121 1 NC_008769.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 76121 leuS 4697737 leuS Mycobacterium bovis BCG str. Pasteur 1173P2 leucyl-tRNA synthetase YP_976174.1 73212 D 410289 CDS YP_976175.1 121635952 4697485 complement(76231..76857) 1 NC_008769.1 transcriptional regulatory protein (marR-family) 76857 4697485 BCG_0073c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein (marR-family) YP_976175.1 76231 R 410289 CDS YP_976176.1 121635953 4695352 complement(77016..77750) 1 NC_008769.1 GntR family transcriptional regulator 77750 4695352 BCG_0074c Mycobacterium bovis BCG str. Pasteur 1173P2 GntR family transcriptional regulator YP_976176.1 77016 R 410289 CDS YP_976177.1 121635954 4697694 complement(77883..78677) 1 NC_008769.1 oxidoreductase 78677 4697694 BCG_0075c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_976177.1 77883 R 410289 CDS YP_976178.1 121635955 4697521 complement(78693..79589) 1 NC_008769.1 hydrolase 79589 4697521 BCG_0076c Mycobacterium bovis BCG str. Pasteur 1173P2 hydrolase YP_976178.1 78693 R 410289 CDS YP_976179.1 121635956 4696669 complement(79671..80774) 1 NC_008769.1 Differs from Mb0047c by 1aa, T120I, and from Rv0046c by 2aa, T120I, G190R; myo-inositol-1-phosphate synthase INO1 80774 ino1 4696669 ino1 Mycobacterium bovis BCG str. Pasteur 1173P2 myo-inositol-1-phosphate synthase INO1 YP_976179.1 79671 R 410289 CDS YP_976180.1 121635957 4697433 complement(80835..81377) 1 NC_008769.1 hypothetical protein 81377 4697433 BCG_0078c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976180.1 80835 R 410289 CDS YP_976181.1 121635958 4698581 complement(81478..82347) 1 NC_008769.1 Differs from Rv0048c by 1aa, A250V; hypothetical protein 82347 4698581 BCG_0079c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976181.1 81478 R 410289 CDS YP_976182.1 121635959 4696521 82481..82894 1 NC_008769.1 hypothetical protein 82894 4696521 BCG_0080 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976182.1 82481 D 410289 CDS YP_976183.1 121635960 4696779 83313..85358 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, insertion of 3 codons after position 632 leads to a slightly longer product compared to its homologs in Mycobacterium tuberculosis strain H37Rv (681 aa versus 678 aa) and Mycobacterium bovis AF2122/97 (681 aa versus 680 aa). In addition, differs from Rv0050 by 1aa, L6P; bifunctional penicillin-binding protein 1A/1B PONA1 85358 ponA1 4696779 ponA1 Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional penicillin-binding protein 1A/1B PONA1 YP_976183.1 83313 D 410289 CDS YP_976184.1 121635961 4696279 85355..87037 1 NC_008769.1 hypothetical protein 87037 4696279 BCG_0082 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976184.1 85355 D 410289 CDS YP_976185.1 121635962 4697704 87069..87632 1 NC_008769.1 hypothetical protein 87632 4697704 BCG_0083 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976185.1 87069 D 410289 CDS YP_976186.1 121635963 4695848 87851..88141 1 NC_008769.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 88141 rpsF 4695848 rpsF Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S6 YP_976186.1 87851 D 410289 CDS YP_976187.1 121635964 4697300 88245..88739 1 NC_008769.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 88739 ssb 4697300 ssb Mycobacterium bovis BCG str. Pasteur 1173P2 single-stranded DNA-binding protein YP_976187.1 88245 D 410289 CDS YP_976188.1 121635965 4695625 88781..89035 1 NC_008769.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 89035 rpsR 4695625 rpsR Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S18 YP_976188.1 88781 D 410289 CDS YP_976189.1 121635966 4695807 89068..89526 1 NC_008769.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 89526 rplI 4695807 rplI Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L9 YP_976189.1 89068 D 410289 CDS YP_976190.1 121635967 4695924 89555..90076 1 NC_008769.1 hypothetical protein 90076 4695924 BCG_0088 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976190.1 89555 D 410289 CDS YP_976191.1 121635968 4696243 90055..92679 1 NC_008769.1 unwinds double stranded DNA; these Mycobacterial enzymes appear to contain inteins; replicative DNA helicase 92679 dnaB 4696243 dnaB Mycobacterium bovis BCG str. Pasteur 1173P2 replicative DNA helicase YP_976191.1 90055 D 410289 CDS YP_976192.1 121635969 4697423 92859..93551 1 NC_008769.1 hypothetical protein 93551 4697423 BCG_0090 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976192.1 92859 D 410289 CDS YP_976193.1 121635970 4697073 93568..94626 1 NC_008769.1 hypothetical protein 94626 4697073 BCG_0091 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976193.1 93568 D 410289 CDS YP_976194.1 121635971 4697355 94650..95075 1 NC_008769.1 hypothetical protein 95075 4697355 BCG_0092 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976194.1 94650 D 410289 CDS YP_976195.1 121635972 4696098 95211..96353 1 NC_008769.1 Differs from Mb0063 by 1aa, A72D, and from Rv0062 by 2aa, A72D, V106I; cellulase celA1 (endoglucanase) 96353 celA1 4696098 celA1 Mycobacterium bovis BCG str. Pasteur 1173P2 cellulase celA1 (endoglucanase) YP_976195.1 95211 D 410289 CDS YP_976196.1 121635973 4697596 96582..98021 1 NC_008769.1 oxidoreductase 98021 4697596 BCG_0094 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_976196.1 96582 D 410289 CDS YP_976197.1 121635974 4696895 98279..101218 1 NC_008769.1 Differs from Mb0065 by 1aa, T435I, and from Rv0064 by 4aa, T435I, D457G, F550V, P906R; hypothetical protein 101218 4696895 BCG_0095 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976197.1 98279 D 410289 CDS YP_976198.1 121635975 4697388 101285..101524 1 NC_008769.1 Differs from Rv0064A by 1aa,V48A; antitoxin 101524 4697388 BCG_0095A Mycobacterium bovis BCG str. Pasteur 1173P2 antitoxin YP_976198.1 101285 D 410289 CDS YP_976199.1 121635976 4697383 101517..101918 1 NC_008769.1 hypothetical protein 101918 4697383 BCG_0096 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976199.1 101517 D 410289 CDS YP_976200.1 121635977 4695423 complement(101970..104207) 1 NC_008769.1 Differs from Rv0066c by 1aa, N117K; isocitrate dehydrogenase 104207 icd2 4695423 icd2 Mycobacterium bovis BCG str. Pasteur 1173P2 isocitrate dehydrogenase YP_976200.1 101970 R 410289 CDS YP_976201.1 121635978 4699214 complement(104325..104894) 1 NC_008769.1 TetR family transcriptional regulator 104894 4699214 BCG_0098c Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_976201.1 104325 R 410289 CDS YP_976202.1 121635979 4697775 104997..105908 1 NC_008769.1 Differs from Rv0068 by 1aa, L214V; short chain dehydrogenase 105908 4697775 BCG_0099 Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_976202.1 104997 D 410289 CDS YP_976203.1 121635980 4696487 complement(105933..107318) 1 NC_008769.1 l-serine dehydratase sdaA 107318 sdaA 4696487 sdaA Mycobacterium bovis BCG str. Pasteur 1173P2 l-serine dehydratase sdaA YP_976203.1 105933 R 410289 CDS YP_976204.1 121635981 4697898 complement(107315..108592) 1 NC_008769.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 108592 glyA 4697898 glyA Mycobacterium bovis BCG str. Pasteur 1173P2 serine hydroxymethyltransferase YP_976204.1 107315 R 410289 CDS YP_976205.1 121635982 4697847 109182..109934 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, a 45 bp insertion (5 copies of VDP repeat) leads to longer products compared to its homologs in Mycobacterium tuberculosis strain H37Rv (250 aa versus 235 aa) and Mycobacterium bovis (250 aa versus 238 aa); maturase 109934 4697847 BCG_0102 Mycobacterium bovis BCG str. Pasteur 1173P2 maturase YP_976205.1 109182 D 410289 CDS YP_976206.1 121635983 4697457 110365..111414 1 NC_008769.1 glutamine ABC transporter 111414 4697457 BCG_0103 Mycobacterium bovis BCG str. Pasteur 1173P2 glutamine ABC transporter YP_976206.1 110365 D 410289 CDS YP_976207.1 121635984 4695394 111417..112409 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv0073 exists as a single gene as in Mycobacterium bovis BCG Pasteur. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Rv0073 into 2 parts, Mb0074 and Mb0075; glutamine ABC transporter ATP-binding protein 112409 4695394 BCG_0104 Mycobacterium bovis BCG str. Pasteur 1173P2 glutamine ABC transporter ATP-binding protein YP_976207.1 111417 D 410289 CDS YP_976208.1 121635985 4698175 112489..113724 1 NC_008769.1 hypothetical protein 113724 4698175 BCG_0105 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976208.1 112489 D 410289 CDS YP_976209.1 121635986 4696342 113737..114909 1 NC_008769.1 Differs from Rv0075 and Mb0077 by 1aa, G326D; aminotransferase 114909 4696342 BCG_0106 Mycobacterium bovis BCG str. Pasteur 1173P2 aminotransferase YP_976209.1 113737 D 410289 CDS YP_976210.1 121635987 4696055 complement(114924..115313) 1 NC_008769.1 hypothetical protein 115313 4696055 BCG_0107c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976210.1 114924 R 410289 CDS YP_976211.1 121635988 4695393 complement(115377..116207) 1 NC_008769.1 oxidoreductase 116207 4695393 BCG_0108c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_976211.1 115377 R 410289 CDS YP_976212.1 121635989 4698145 116269..116874 1 NC_008769.1 Differs from Rv0078 by 1aa, V113I; transcriptional regulatory protein 116874 4698145 BCG_0109 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976212.1 116269 D 410289 CDS YP_976213.1 121635990 4696050 complement(116949..117542) 1 NC_008769.1 hypothetical protein 117542 4696050 BCG_0110c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976213.1 116949 R 410289 CDS YP_976214.1 121635991 4697451 complement(117539..117751) 1 NC_008769.1 hypothetical protein 117751 4697451 BCG_0111c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976214.1 117539 R 410289 CDS YP_976215.1 121635992 4697996 117945..118766 1 NC_008769.1 hypothetical protein 118766 4697996 BCG_0112 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976215.1 117945 D 410289 CDS YP_976216.1 121635993 4695860 118763..119221 1 NC_008769.1 Differs from Mb0083 by 1aa, C35R, and from Rv0080 by 2aa, C35R, V60G; hypothetical protein 119221 4695860 BCG_0113 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976216.1 118763 D 410289 CDS YP_976217.1 121635994 4698066 119316..119660 1 NC_008769.1 transcriptional regulatory protein 119660 4698066 BCG_0114 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976217.1 119316 D 410289 CDS YP_976218.1 121635995 4695863 119665..120144 1 NC_008769.1 Differs from Rv0082 by 1aa, R74Q; oxidoreductase 120144 4695863 BCG_0115 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_976218.1 119665 D 410289 CDS YP_976219.1 121635996 4697023 120141..122069 1 NC_008769.1 In Mycobacterium bovis, a single base transversion (a-t) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (642 aa versus 640 aa). Differs from Mb0086 by 1aa, A177V; oxidoreductase 122069 4697023 BCG_0116 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_976219.1 120141 D 410289 CDS YP_976220.1 121635997 4695375 122069..123019 1 NC_008769.1 formate hydrogenlyase hycD (FHL) 123019 hycD 4695375 hycD Mycobacterium bovis BCG str. Pasteur 1173P2 formate hydrogenlyase hycD (FHL) YP_976220.1 122069 D 410289 CDS YP_976221.1 121635998 4697265 123030..123692 1 NC_008769.1 hydrogenase hycP 123692 hycP 4697265 hycP Mycobacterium bovis BCG str. Pasteur 1173P2 hydrogenase hycP YP_976221.1 123030 D 410289 CDS YP_976222.1 121635999 4697267 123692..125158 1 NC_008769.1 Differs from Rv0086 by 1aa, T118M; hydrogenase hycQ 125158 hycQ 4697267 hycQ Mycobacterium bovis BCG str. Pasteur 1173P2 hydrogenase hycQ YP_976222.1 123692 D 410289 CDS YP_976223.1 121636000 4697268 125155..126633 1 NC_008769.1 Differs from Rv0087 by 1aa, I230V; formate hydrogenase hycQ (FHL) 126633 hycE 4697268 hycE Mycobacterium bovis BCG str. Pasteur 1173P2 formate hydrogenase hycQ (FHL) YP_976223.1 125155 D 410289 CDS YP_976224.1 121636001 4697266 126668..127342 1 NC_008769.1 hypothetical protein 127342 4697266 BCG_0121 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976224.1 126668 D 410289 CDS YP_976225.1 121636002 4695770 127499..128092 1 NC_008769.1 methyltransferase/methylase 128092 4695770 BCG_0122 Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase/methylase YP_976225.1 127499 D 410289 CDS YP_976226.1 121636003 4695984 128221..128991 1 NC_008769.1 hypothetical protein 128991 4695984 BCG_0123 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976226.1 128221 D 410289 CDS YP_976227.1 121636004 4697519 129425..130192 1 NC_008769.1 bifunctional MTA/SAH nucleosidase mtn 130192 mtn 4697519 mtn Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional MTA/SAH nucleosidase mtn YP_976227.1 129425 D 410289 CDS YP_976228.1 121636005 4697738 130324..132609 1 NC_008769.1 Differs from Rv0092 by 1aa, A3T; cation transporter p-type atpase A ctpA 132609 ctpA 4697738 ctpA Mycobacterium bovis BCG str. Pasteur 1173P2 cation transporter p-type atpase A ctpA YP_976228.1 130324 D 410289 CDS YP_976229.1 121636006 4697724 complement(132556..133404) 1 NC_008769.1 Differs from Rv0093c by 1aa, R22C; hypothetical protein 133404 4697724 BCG_0126c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976229.1 132556 R 410289 CDS YP_976230.1 121636007 4696049 complement(133451..134404) 1 NC_008769.1 Differs from Rv0094c by 3aa, D256E, W296R, K315E; hypothetical protein 134404 4696049 BCG_0127c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976230.1 133451 R 410289 CDS YP_976231.1 121636008 4698785 complement(134175..134957) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv0095c and Rv1588 exist as separate genes in their respective positions. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 73 bp substitution leads to a single combined gene. Differs from Rv0095c by 5aa, E57D, T70S, V85A, V91G, A92Q; hypothetical protein 134957 4698785 BCG_0128c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976231.1 134175 R 410289 CDS YP_976232.1 121636009 4697111 135066..136457 1 NC_008769.1 Differs from Rv0096 by 1aa, W182R; PPE family protein 136457 PPE1 4697111 PPE1 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_976232.1 135066 D 410289 CDS YP_976233.1 121636010 4696160 136476..137345 1 NC_008769.1 oxidoreductase 137345 4696160 BCG_0130 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_976233.1 136476 D 410289 CDS YP_976234.1 121636011 4697693 137342..137893 1 NC_008769.1 hypothetical protein 137893 4697693 BCG_0131 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976234.1 137342 D 410289 CDS YP_976235.1 121636012 4697870 137898..139520 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 139520 fadD10 4697870 fadD10 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_976235.1 137898 D 410289 CDS YP_976236.1 121636013 4695648 139525..139761 1 NC_008769.1 hypothetical protein 139761 4695648 BCG_0133 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976236.1 139525 D 410289 CDS YP_976237.1 121636014 4696972 139743..147281 1 NC_008769.1 peptide synthetase nrp 147281 nrp 4696972 nrp Mycobacterium bovis BCG str. Pasteur 1173P2 peptide synthetase nrp YP_976237.1 139743 D 410289 CDS YP_976238.1 121636015 4699183 147456..149441 1 NC_008769.1 integral membrane protein 149441 4699183 BCG_0135 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_976238.1 147456 D 410289 CDS YP_976239.1 121636016 4697602 complement(149657..151915) 1 NC_008769.1 Differs from Rv0103c by 1aa, S22L; cation-transporter P-type atpase B ctpB 151915 ctpB 4697602 ctpB Mycobacterium bovis BCG str. Pasteur 1173P2 cation-transporter P-type atpase B ctpB YP_976239.1 149657 R 410289 CDS YP_976240.1 121636017 4697687 152059..153573 1 NC_008769.1 hypothetical protein 153573 4697687 BCG_0137 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976240.1 152059 D 410289 CDS YP_976241.1 121636018 4695457 complement(153722..154006) 1 NC_008769.1 required for 70S ribosome assembly; 50S ribosomal protein L28 154006 rpmB 4695457 rpmB Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L28 YP_976241.1 153722 R 410289 CDS YP_976242.1 121636019 4697629 154116..155312 1 NC_008769.1 hypothetical protein 155312 4697629 BCG_0139 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976242.1 154116 D 410289 CDS YP_976243.1 121636020 4696800 complement(155407..160284) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-t) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; differs from Rv0107c by 3aa, V136A, P1247S, S1327A; cation-transporter atpase I ctpI 160284 ctpI 4696800 ctpI Mycobacterium bovis BCG str. Pasteur 1173P2 cation-transporter atpase I ctpI YP_976243.1 155407 R 410289 CDS YP_976244.1 121636021 4697539 complement(160638..160847) 1 NC_008769.1 hypothetical protein 160847 4697539 BCG_0141c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976244.1 160638 R 410289 CDS YP_976245.1 121636022 4698119 161126..162616 1 NC_008769.1 Differs from Rv0109 by 1aa, G346R; PE-PGRS family protein 162616 PE_PGRS1 4698119 PE_PGRS1 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_976245.1 161126 D 410289 CDS YP_976246.1 121636023 4696296 162764..163513 1 NC_008769.1 integral membrane protein 163513 4696296 BCG_0143 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_976246.1 162764 D 410289 CDS YP_976247.1 121636024 4697514 163694..165751 1 NC_008769.1 acyltransferase 165751 4697514 BCG_0144 Mycobacterium bovis BCG str. Pasteur 1173P2 acyltransferase YP_976247.1 163694 D 410289 CDS YP_976248.1 121636025 4696313 166033..166989 1 NC_008769.1 GDP-mannose 4,6-dehydratase 166989 gca 4696313 gca Mycobacterium bovis BCG str. Pasteur 1173P2 GDP-mannose 4,6-dehydratase YP_976248.1 166033 D 410289 CDS YP_976249.1 121636026 4696528 167063..167653 1 NC_008769.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 167653 gmhA 4696528 gmhA Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoheptose isomerase YP_976249.1 167063 D 410289 CDS YP_976250.1 121636027 4697849 167685..168257 1 NC_008769.1 Differs from Rv0114 by 1aa, R121G; dehydratase 168257 4697849 BCG_0147 Mycobacterium bovis BCG str. Pasteur 1173P2 dehydratase YP_976250.1 167685 D 410289 CDS YP_976251.1 121636028 4697418 168257..169324 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-c) equivalent to Mycobacterium tuberculosis H37Rv position 139559, leads to shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. In addition, in Mycobacterium bovis, a single base insertion, at position equivalent to 138823, leads to a different NH2 part; sugar kinase 169324 4697418 BCG_0149 Mycobacterium bovis BCG str. Pasteur 1173P2 sugar kinase YP_976251.1 168257 D 410289 CDS YP_976252.1 121636029 4695709 complement(170012..170767) 1 NC_008769.1 hypothetical protein 170767 4695709 BCG_0150c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976252.1 170012 R 410289 CDS YP_976253.1 121636030 4697654 170945..171889 1 NC_008769.1 oxidative stress response regulatory protein oxyS 171889 oxyS 4697654 oxyS Mycobacterium bovis BCG str. Pasteur 1173P2 oxidative stress response regulatory protein oxyS YP_976253.1 170945 D 410289 CDS YP_976254.1 121636031 4695405 complement(171873..173621) 1 NC_008769.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase 173621 oxcA 4695405 oxcA Mycobacterium bovis BCG str. Pasteur 1173P2 oxalyl-CoA decarboxylase YP_976254.1 171873 R 410289 CDS YP_976255.1 121636032 4695404 173794..175371 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 175371 fadD7 4695404 fadD7 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_976255.1 173794 D 410289 CDS YP_976256.1 121636033 4696274 complement(175372..177516) 1 NC_008769.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 177516 fusA2b 4696274 fusA2b Mycobacterium bovis BCG str. Pasteur 1173P2 elongation factor G YP_976256.1 175372 R 410289 CDS YP_976257.1 121636034 4695507 complement(177652..178086) 1 NC_008769.1 hypothetical protein 178086 4695507 BCG_0155c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976257.1 177652 R 410289 CDS YP_976258.1 121636035 4696264 178235..178603 1 NC_008769.1 hypothetical protein 178603 4696264 BCG_0156 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976258.1 178235 D 410289 CDS YP_976259.1 121636036 4695590 178600..178968 1 NC_008769.1 hypothetical protein 178968 4695590 BCG_0157 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976259.1 178600 D 410289 CDS YP_976260.1 121636037 4695953 179277..180893 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 180 bp insertion leads to a longer product in the 3' direction compared to its homolog in Mycobacterium tuberculosis strain H37Rv (538 aa versus 487 aa); PE-PGRS family protein 180893 PE_PGRS2 4695953 PE_PGRS2 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_976260.1 179277 D 410289 CDS YP_976261.1 121636038 4697722 181045..182112 1 NC_008769.1 serine protease pepA 182112 pepA 4697722 pepA Mycobacterium bovis BCG str. Pasteur 1173P2 serine protease pepA YP_976261.1 181045 D 410289 CDS YP_976262.1 121636039 4696118 182221..184026 1 NC_008769.1 trehalose synthase treS 184026 treS 4696118 treS Mycobacterium bovis BCG str. Pasteur 1173P2 trehalose synthase treS YP_976262.1 182221 D 410289 CDS YP_976263.1 121636040 4696821 184129..185496 1 NC_008769.1 Differs from Rv0127 by 1aa, P18S; hypothetical protein 185496 4696821 BCG_0161 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976263.1 184129 D 410289 CDS YP_976264.1 121636041 4697426 185564..186343 1 NC_008769.1 hypothetical protein 186343 4697426 BCG_0162 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976264.1 185564 D 410289 CDS YP_976265.1 121636042 4697184 complement(186475..187497) 1 NC_008769.1 hypothetical protein 187497 fbpC 4697184 fbpC Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976265.1 186475 R 410289 CDS YP_976266.1 121636043 4696522 187744..188199 1 NC_008769.1 hypothetical protein 188199 4696522 BCG_0164 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976266.1 187744 D 410289 CDS YP_976267.1 121636044 4695959 complement(188212..189555) 1 NC_008769.1 acyl-CoA dehydrogenase fadE1 189555 fadE1 4695959 fadE1 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE1 YP_976267.1 188212 R 410289 CDS YP_976268.1 121636045 4695872 complement(189597..190679) 1 NC_008769.1 Differs from Rv0132c by 1aa, E147K; F420-dependent glucose-6-phosphate dehydrogenase 190679 fgd2 4695872 fgd2 Mycobacterium bovis BCG str. Pasteur 1173P2 F420-dependent glucose-6-phosphate dehydrogenase YP_976268.1 189597 R 410289 CDS YP_976269.1 121636046 4695794 190766..191248 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis AF2122/97, codon 161 is TAC and in Mycobacterium bovis BCG Pasteur, TAA; acetyltransferase 191248 4695794 BCG_0167 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyltransferase YP_976269.1 190766 D 410289 CDS YP_976270.1 121636047 4696778 complement(192541..193146) 1 NC_008769.1 transcriptional regulatory protein 193146 4696778 BCG_0171c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976270.1 192541 R 410289 CDS YP_976271.1 121636048 4696345 193263..194588 1 NC_008769.1 cytochrome p450 138 cyp138 194588 cyp138 4696345 cyp138 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome p450 138 cyp138 YP_976271.1 193263 D 410289 CDS YP_976272.1 121636049 4696607 complement(194609..195157) 1 NC_008769.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 195157 msrA 4696607 msrA Mycobacterium bovis BCG str. Pasteur 1173P2 methionine sulfoxide reductase A YP_976272.1 194609 R 410289 CDS YP_976273.1 121636050 4697736 195220..195723 1 NC_008769.1 Differs from Mb0143 by 1aa, D96G; hypothetical protein 195723 4697736 BCG_0174 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976273.1 195220 D 410289 CDS YP_976274.1 121636051 4697886 195724..196746 1 NC_008769.1 Differs from Rv0139 by 1aa, R227H; oxidoreductase 196746 4697886 BCG_0175 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_976274.1 195724 D 410289 CDS YP_976275.1 121636052 4696471 196807..197187 1 NC_008769.1 hypothetical protein 197187 4696471 BCG_0176 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976275.1 196807 D 410289 CDS YP_976276.1 121636053 4697244 complement(197168..197578) 1 NC_008769.1 hypothetical protein 197578 4697244 BCG_0177c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976276.1 197168 R 410289 CDS YP_976277.1 121636054 4695477 197608..198534 1 NC_008769.1 hypothetical protein 198534 4695477 BCG_0178 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976277.1 197608 D 410289 CDS YP_976278.1 121636055 4696266 complement(198601..200079) 1 NC_008769.1 Differs from Rv0143c by 1aa, L34F; hypothetical protein 200079 4696266 BCG_0179c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976278.1 198601 R 410289 CDS YP_976279.1 121636056 4697048 200181..201023 1 NC_008769.1 TetR family transcriptional regulator 201023 4697048 BCG_0180 Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_976279.1 200181 D 410289 CDS YP_976280.1 121636057 4696148 201112..202065 1 NC_008769.1 hypothetical protein 202065 4696148 BCG_0181 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976280.1 201112 D 410289 CDS YP_976281.1 121636058 4695365 202108..203040 1 NC_008769.1 hypothetical protein 203040 4695365 BCG_0182 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976281.1 202108 D 410289 CDS YP_976282.1 121636059 4695675 203135..204655 1 NC_008769.1 aldehyde dehydrogenase 204655 4695675 BCG_0183 Mycobacterium bovis BCG str. Pasteur 1173P2 aldehyde dehydrogenase YP_976282.1 203135 D 410289 CDS YP_976283.1 121636060 4697099 204730..205590 1 NC_008769.1 short-chain type dehydrogenase/reductase 205590 4697099 BCG_0184 Mycobacterium bovis BCG str. Pasteur 1173P2 short-chain type dehydrogenase/reductase YP_976283.1 204730 D 410289 CDS YP_976284.1 121636061 4698796 205597..206565 1 NC_008769.1 quinone oxidoreductase 206565 4698796 BCG_0185 Mycobacterium bovis BCG str. Pasteur 1173P2 quinone oxidoreductase YP_976284.1 205597 D 410289 CDS YP_976285.1 121636062 4697427 complement(206562..206849) 1 NC_008769.1 hypothetical protein 206849 4697427 BCG_0186c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976285.1 206562 R 410289 CDS YP_976286.1 121636063 4697778 complement(207440..209206) 1 NC_008769.1 Differs from Rv0151c by 1aa, R26G; PE family protein 209206 PE1 4697778 PE1 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_976286.1 207440 R 410289 CDS YP_976287.1 121636064 4695743 complement(209216..210793) 1 NC_008769.1 PE family protein 210793 PE2 4695743 PE2 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_976287.1 209216 R 410289 CDS YP_976288.1 121636065 4699376 complement(211052..211882) 1 NC_008769.1 Differs from Rv0153c by 1aa, G105D; phosphotyrosine protein phosphatase ptpB 211882 ptbB 4699376 ptbB Mycobacterium bovis BCG str. Pasteur 1173P2 phosphotyrosine protein phosphatase ptpB YP_976288.1 211052 R 410289 CDS YP_976289.1 121636066 4697316 complement(211884..213095) 1 NC_008769.1 acyl-CoA dehydrogenase fadE2 213095 fadE2 4697316 fadE2 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE2 YP_976289.1 211884 R 410289 CDS YP_976290.1 121636067 4699118 213519..214619 1 NC_008769.1 NAD(p) transhydrogenase (subunit alpha) pntAa 214619 pntAa 4699118 pntAa Mycobacterium bovis BCG str. Pasteur 1173P2 NAD(p) transhydrogenase (subunit alpha) pntAa YP_976290.1 213519 D 410289 CDS YP_976291.1 121636068 4696817 214620..214952 1 NC_008769.1 Differs from Rv0156 by 1aa, C2Y; NAD(p) transhydrogenase (subunit alpha) pntAb 214952 pntAb 4696817 pntAb Mycobacterium bovis BCG str. Pasteur 1173P2 NAD(p) transhydrogenase (subunit alpha) pntAb YP_976291.1 214620 D 410289 CDS YP_976292.1 121636069 4696818 214949..216376 1 NC_008769.1 NAD(p) transhydrogenase (subunit beta) pntB 216376 pntB 4696818 pntB Mycobacterium bovis BCG str. Pasteur 1173P2 NAD(p) transhydrogenase (subunit beta) pntB YP_976292.1 214949 D 410289 CDS YP_976293.1 121636070 4696277 216682..217326 1 NC_008769.1 TetR family transcriptional regulator 217326 4696277 BCG_0194 Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_976293.1 216682 D 410289 CDS YP_976294.1 121636071 4696051 complement(217330..218736) 1 NC_008769.1 Differs from Rv0159c by 1aa, T255P; PE family protein 218736 PE3 4696051 PE3 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_976294.1 217330 R 410289 CDS YP_976295.1 121636072 4698937 complement(218828..220336) 1 NC_008769.1 Differs from Rv0160c by 2aa, T116A, T211A; PE family protein 220336 PE4 4698937 PE4 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_976295.1 218828 R 410289 CDS YP_976296.1 121636073 4696201 220504..221853 1 NC_008769.1 oxidoreductase 221853 4696201 BCG_0197 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_976296.1 220504 D 410289 CDS YP_976297.1 121636074 4698436 complement(221881..223032) 1 NC_008769.1 Differs from Rv0162c and Mb0167c by 1aa, R41H; zinc-type alcohol dehydrogenase (e subunit) adhE 223032 adhE1 4698436 adhE1 Mycobacterium bovis BCG str. Pasteur 1173P2 zinc-type alcohol dehydrogenase (e subunit) adhE YP_976297.1 221881 R 410289 CDS YP_976298.1 121636075 4697252 223014..223469 1 NC_008769.1 hypothetical protein 223469 4697252 BCG_0199 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976298.1 223014 D 410289 CDS YP_976299.1 121636076 4697507 223523..224008 1 NC_008769.1 hypothetical protein 224008 TB18.5 4697507 TB18.5 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976299.1 223523 D 410289 CDS YP_976300.1 121636077 4697561 complement(224022..224837) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv0165c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a 2 bp insertion (*-cc) leads to a product with a different COOH terminus; GntR family transcriptional regulator 224837 4697561 BCG_0201c Mycobacterium bovis BCG str. Pasteur 1173P2 GntR family transcriptional regulator YP_976300.1 224022 R 410289 CDS YP_976301.1 121636078 4697652 224892..226556 1 NC_008769.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 226556 fadD5 4697652 fadD5 Mycobacterium bovis BCG str. Pasteur 1173P2 long-chain-fatty-acid--CoA ligase YP_976301.1 224892 D 410289 CDS YP_976302.1 121636079 4696272 226760..227557 1 NC_008769.1 integral membrane protein YrbE1a 227557 yrbE1A 4696272 yrbE1A Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YrbE1a YP_976302.1 226760 D 410289 CDS YP_976303.1 121636080 4697801 227559..228428 1 NC_008769.1 integral membrane protein YrbE1b 228428 yrbE1B 4697801 yrbE1B Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YrbE1b YP_976303.1 227559 D 410289 CDS YP_976304.1 121636081 4697802 228433..229797 1 NC_008769.1 Differs from Rv0169 by 2aa, A313S, S359P; Differs from Rv0169 by 2aa, A313S, S359P; MCE-family protein mce1A 229797 mce1A 4697802 mce1A Mycobacterium bovis BCG str. Pasteur 1173P2 MCE-family protein mce1A YP_976304.1 228433 D 410289 CDS YP_976305.1 121636082 4695351 229794..230834 1 NC_008769.1 Differs from Rv0170 by 1aa, T179I; MCE-family protein mce1B 230834 mce1B 4695351 mce1B Mycobacterium bovis BCG str. Pasteur 1173P2 MCE-family protein mce1B YP_976305.1 229794 D 410289 CDS YP_976306.1 121636083 4697196 230831..232378 1 NC_008769.1 Differs from Rv0171 by 1aa, D212E; MCE-family protein mce1C 232378 mce1C 4697196 mce1C Mycobacterium bovis BCG str. Pasteur 1173P2 MCE-family protein mce1C YP_976306.1 230831 D 410289 CDS YP_976307.1 121636084 4697197 232375..233967 1 NC_008769.1 MCE-family protein mce1D 233967 mce1D 4697197 mce1D Mycobacterium bovis BCG str. Pasteur 1173P2 MCE-family protein mce1D YP_976307.1 232375 D 410289 CDS YP_976308.1 121636085 4697198 233964..235136 1 NC_008769.1 mce family lipoprotein LprK 235136 lprK 4697198 lprK Mycobacterium bovis BCG str. Pasteur 1173P2 mce family lipoprotein LprK YP_976308.1 233964 D 410289 CDS YP_976309.1 121636086 4698588 235130..236677 1 NC_008769.1 Differs from Rv0174 by 1aa, P370L; MCE-family protein mce1F 236677 mce1F 4698588 mce1F Mycobacterium bovis BCG str. Pasteur 1173P2 MCE-family protein mce1F YP_976309.1 235130 D 410289 CDS YP_976310.1 121636087 4697199 236713..237354 1 NC_008769.1 mce associated membrane protein 237354 4697199 BCG_0212 Mycobacterium bovis BCG str. Pasteur 1173P2 mce associated membrane protein YP_976310.1 236713 D 410289 CDS YP_976311.1 121636088 4697872 237351..238319 1 NC_008769.1 Differs from Mb0182 by 1aa, S285N, and from Rv0176 by 3aa, S285N, S290Q, A291S; mce associated transmembrane protein 238319 4697872 BCG_0213 Mycobacterium bovis BCG str. Pasteur 1173P2 mce associated transmembrane protein YP_976311.1 237351 D 410289 CDS YP_976312.1 121636089 4697011 238316..238870 1 NC_008769.1 mce associated protein 238870 4697011 BCG_0214 Mycobacterium bovis BCG str. Pasteur 1173P2 mce associated protein YP_976312.1 238316 D 410289 CDS YP_976313.1 121636090 4696892 238837..239571 1 NC_008769.1 MCE associated membrane protein 239571 4696892 BCG_0215 Mycobacterium bovis BCG str. Pasteur 1173P2 MCE associated membrane protein YP_976313.1 238837 D 410289 CDS YP_976314.1 121636091 4696358 complement(239602..240711) 1 NC_008769.1 Differs from Rv0179c by 1aa, H124R; lipoprotein lprO 240711 lprO 4696358 lprO Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lprO YP_976314.1 239602 R 410289 CDS YP_976315.1 121636092 4698591 complement(240791..242149) 1 NC_008769.1 hypothetical protein 242149 4698591 BCG_0217c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976315.1 240791 R 410289 CDS YP_976316.1 121636093 4697013 complement(242176..242910) 1 NC_008769.1 hypothetical protein 242910 4697013 BCG_0218c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976316.1 242176 R 410289 CDS YP_976317.1 121636094 4695936 complement(242927..244039) 1 NC_008769.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; RNA polymerase factor sigma-70 244039 sigG 4695936 sigG Mycobacterium bovis BCG str. Pasteur 1173P2 RNA polymerase factor sigma-70 YP_976317.1 242927 R 410289 CDS YP_976318.1 121636095 4695354 243987..244826 1 NC_008769.1 lysophospholipase 244826 4695354 BCG_0220 Mycobacterium bovis BCG str. Pasteur 1173P2 lysophospholipase YP_976318.1 243987 D 410289 CDS YP_976319.1 121636096 4697419 244868..245617 1 NC_008769.1 hypothetical protein 245617 4697419 BCG_0221 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976319.1 244868 D 410289 CDS YP_976320.1 121636097 4695540 245614..246123 1 NC_008769.1 hypothetical protein 246123 4695540 BCG_0222 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976320.1 245614 D 410289 CDS YP_976321.1 121636098 4697390 246168..248243 1 NC_008769.1 Differs from Mb0192 by 1aa, S504I, and from Rv0186 by 2aa, S504I, R532P; beta-glucosidase bglS 248243 bglS 4697390 bglS Mycobacterium bovis BCG str. Pasteur 1173P2 beta-glucosidase bglS YP_976321.1 246168 D 410289 CDS YP_976322.1 121636099 4696688 248604..249266 1 NC_008769.1 Differs from Rv0187 and Mb0193 by 1aa, V147A; o-methyltransferase 249266 4696688 BCG_0224 Mycobacterium bovis BCG str. Pasteur 1173P2 o-methyltransferase YP_976322.1 248604 D 410289 CDS YP_976323.1 121636100 4697406 249385..249816 1 NC_008769.1 hypothetical protein 249816 4697406 BCG_0225 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976323.1 249385 D 410289 CDS YP_976324.1 121636101 4697026 complement(249895..251622) 1 NC_008769.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 251622 ilvD 4697026 ilvD Mycobacterium bovis BCG str. Pasteur 1173P2 dihydroxy-acid dehydratase YP_976324.1 249895 R 410289 CDS YP_976325.1 121636102 4699341 251770..252060 1 NC_008769.1 hypothetical protein 252060 4699341 BCG_0227 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976325.1 251770 D 410289 CDS YP_976326.1 121636103 4696104 252188..253429 1 NC_008769.1 integral membrane protein 253429 4696104 BCG_0228 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_976326.1 252188 D 410289 CDS YP_976327.1 121636104 4698256 253506..254564 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv0192 and Rv0192A exist as 2 genes with an overlap region. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-g) leads to a single product. Differs from Mb0198 by 1aa, A279V and from Rv0192 by 2aa, P113S, A279V; hypothetical protein 254564 4698256 BCG_0229 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976327.1 253506 D 410289 CDS YP_976328.1 121636105 4698698 complement(254624..256471) 1 NC_008769.1 Differs from Rv0193c and Mb0199c by 1aa, E417K; hypothetical protein 256471 4698698 BCG_0230c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976328.1 254624 R 410289 CDS YP_976329.1 121636106 4698450 256778..260362 1 NC_008769.1 Differs from Mb0200 by 1aa, I49V, and from Rv0194 by 2aa, T74M, M223T; drugs-transport transmembrane ATP-binding protein ABC transporter 260362 4698450 BCG_0231 Mycobacterium bovis BCG str. Pasteur 1173P2 drugs-transport transmembrane ATP-binding protein ABC transporter YP_976329.1 256778 D 410289 CDS YP_976330.1 121636107 4695751 260800..261435 1 NC_008769.1 LuxR family two component transcriptional regulator 261435 4695751 BCG_0232 Mycobacterium bovis BCG str. Pasteur 1173P2 LuxR family two component transcriptional regulator YP_976330.1 260800 D 410289 CDS YP_976331.1 121636108 4695509 261548..262132 1 NC_008769.1 transcriptional regulatory protein 262132 4695509 BCG_0233 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976331.1 261548 D 410289 CDS YP_976332.1 121636109 4695763 262132..264378 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transversion (t-g) introduces a stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (748 aa versus 762 aa). Differs from Rv0197 by 1aa, S378R; oxidoreductase 264378 4695763 BCG_0234 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_976332.1 262132 D 410289 CDS YP_976333.1 121636110 4696246 complement(264419..266410) 1 NC_008769.1 zinc metalloprotease 266410 4696246 BCG_0235c Mycobacterium bovis BCG str. Pasteur 1173P2 zinc metalloprotease YP_976333.1 264419 R 410289 CDS YP_976334.1 121636111 4696352 266453..267112 1 NC_008769.1 hypothetical protein 267112 4696352 BCG_0236 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976334.1 266453 D 410289 CDS YP_976335.1 121636112 4696349 267109..267798 1 NC_008769.1 hypothetical protein 267798 4696349 BCG_0237 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976335.1 267109 D 410289 CDS YP_976336.1 121636113 4696741 complement(267795..268298) 1 NC_008769.1 hypothetical protein 268298 4696741 BCG_0238c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976336.1 267795 R 410289 CDS YP_976337.1 121636114 4696794 complement(268295..271195) 1 NC_008769.1 transmembrane transport protein mmpL11 271195 mmpL11 4696794 mmpL11 Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane transport protein mmpL11 YP_976337.1 268295 R 410289 CDS YP_976338.1 121636115 4697541 271417..271827 1 NC_008769.1 Differs from Rv0203 and Mb0209 by 1aa, T88K; hypothetical protein 271827 4697541 BCG_0240 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976338.1 271417 D 410289 CDS YP_976339.1 121636116 4696793 complement(271879..273162) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, the presence of a more likely start codon leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (427 a versus 412 aa). Differs from Rv0204c by 1aa, L321V; hypothetical protein 273162 4696793 BCG_0241c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976339.1 271879 R 410289 CDS YP_976340.1 121636117 4697022 273287..274390 1 NC_008769.1 Differs from Rv0205 by 1aa, R72H; hypothetical protein 274390 4697022 BCG_0242 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976340.1 273287 D 410289 CDS YP_976341.1 121636118 4697222 complement(274387..277221) 1 NC_008769.1 Differs from Rv0206c by 2aa, I384F, E466D; transmembrane transport protein mmpL3 277221 mmpL3 4697222 mmpL3 Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane transport protein mmpL3 YP_976341.1 274387 R 410289 CDS YP_976342.1 121636119 4695521 complement(277287..278015) 1 NC_008769.1 hypothetical protein 278015 4695521 BCG_0244c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976342.1 277287 R 410289 CDS YP_976343.1 121636120 4697253 complement(278018..278809) 1 NC_008769.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 278809 trmB 4697253 trmB Mycobacterium bovis BCG str. Pasteur 1173P2 tRNA (guanine-N(7)-)-methyltransferase YP_976343.1 278018 R 410289 CDS YP_976344.1 121636121 4697234 278941..280026 1 NC_008769.1 Differs from Rv0209 by 1aa, A162V; hypothetical protein 280026 4697234 BCG_0246 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976344.1 278941 D 410289 CDS YP_976345.1 121636122 4699331 280023..281501 1 NC_008769.1 Differs from Rv0210 by 1aa, T486A; hypothetical protein 281501 4699331 BCG_0247 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976345.1 280023 D 410289 CDS YP_976346.1 121636123 4697998 281685..283505 1 NC_008769.1 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP; phosphoenolpyruvate carboxykinase 283505 pckA 4697998 pckA Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoenolpyruvate carboxykinase YP_976346.1 281685 D 410289 CDS YP_976347.1 121636124 4698418 complement(283572..284543) 1 NC_008769.1 transcriptional regulator NadR 284543 nadR 4698418 nadR Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulator NadR YP_976347.1 283572 R 410289 CDS YP_976348.1 121636125 4696616 complement(284540..285853) 1 NC_008769.1 methyltransferase 285853 4696616 BCG_0250c Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase YP_976348.1 284540 R 410289 CDS YP_976349.1 121636126 4697727 285967..287580 1 NC_008769.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 287580 fadD4 4697727 fadD4 Mycobacterium bovis BCG str. Pasteur 1173P2 long-chain-fatty-acid--CoA ligase YP_976349.1 285967 D 410289 CDS YP_976350.1 121636127 4696271 complement(287622..288788) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 29 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (388 aa versus 357 aa). Differs from Mb0221c by 1aa, S361A; acyl-CoA dehydrogenase fadE3 288788 fadE3 4696271 fadE3 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE3 YP_976350.1 287622 R 410289 CDS YP_976351.1 121636128 4697579 288845..289858 1 NC_008769.1 hypothetical protein 289858 4697579 BCG_0253 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976351.1 288845 D 410289 CDS YP_976352.1 121636129 4698090 complement(289855..290763) 1 NC_008769.1 Differs from Rv0217c by 1aa T184P; esterase lipW 290763 lipW 4698090 lipW Mycobacterium bovis BCG str. Pasteur 1173P2 esterase lipW YP_976352.1 289855 R 410289 CDS YP_976353.1 121636130 4695784 290856..292184 1 NC_008769.1 Differs from Rv0218 by 2aa, R316C, N413D; hypothetical protein 292184 4695784 BCG_0255 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976353.1 290856 D 410289 CDS YP_976354.1 121636131 4697761 292186..292734 1 NC_008769.1 hypothetical protein 292734 4697761 BCG_0256 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976354.1 292186 D 410289 CDS YP_976355.1 121636132 4699256 292744..293985 1 NC_008769.1 esterase lipC 293985 lipC 4699256 lipC Mycobacterium bovis BCG str. Pasteur 1173P2 esterase lipC YP_976355.1 292744 D 410289 CDS YP_976356.1 121636133 4698688 293999..294772 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, RD10, a 1902 bp deletion leads to a shorter product with a different COOH part, compared to its homolog in Mycobacterium tuberculosis strain H37Rv (257 aa versus 469 aa). It also leads to the deletion of the next protein, echA1 (Rv0222); hypothetical protein 294772 4698688 BCG_0258 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976356.1 293999 D 410289 CDS YP_976357.1 121636134 4698049 complement(294638..295447) 1 NC_008769.1 In mycobacterium bovis strain AF2122/97 and Mycobacterium bovis BCG Pasteur, RD10, a 1902 bp deletion, compared to Mycobacterium tuberculosis H37Rv, truncates Rv0221c and Rv0223c and removes Rv0222c; In Mycobacterium bovis BCG Pasteur, a single base deletion at position equivalent to Mycobacterium tuberculosis H37Rv2 267419-267419(*-c) splits gene into two parts compared to its homologs in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis AF2122/97 (116 aa and 269 aa, versus 487 aa and 385 aa, respectively. Also has same 1 bp insertion, as Mycobacterium bovis AF2122/97, at position equivalent to Mycobacterium tuberculosis H37Rv2 base 266743. Deletion in Mycobacterium bovis and bovis BCG Pasteur of region RD10 leads to a different COOH part compared to Mycobacterium tuberculosis strain H37Rv. May be pseudogene; aldehyde dehydrogenase 295447 4698049 BCG_0259c Mycobacterium bovis BCG str. Pasteur 1173P2 aldehyde dehydrogenase YP_976357.1 294638 R 410289 CDS YP_976358.1 121636135 4698185 complement(295444..295794) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, a single base deletion at position equivalent to Mycobacterium tuberculosis H37Rv2 267419-267419(*-c) splits gene into two parts compared to its homologs in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis AF2122/97 (116 aa and 269 aa, versus 487 aa and 385 aa, respectively. Also has same 1 bp insertion, as Mycobacterium bovis AF2122/97, at position equivalent to Mycobacterium tuberculosis H37Rv2 base 266743. May be pseudogene; aldehyde dehydrogenase 295794 4698185 BCG_0260c Mycobacterium bovis BCG str. Pasteur 1173P2 aldehyde dehydrogenase YP_976358.1 295444 R 410289 CDS YP_976359.1 121636136 4699063 complement(295893..296657) 1 NC_008769.1 Differs from Rv0224c by 1aa, L117F; methyltransferase 296657 4699063 BCG_0261c Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase YP_976359.1 295893 R 410289 CDS YP_976360.1 121636137 4699029 296693..297847 1 NC_008769.1 hypothetical protein 297847 4699029 BCG_0262 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976360.1 296693 D 410289 CDS YP_976361.1 121636138 4698239 complement(297864..299594) 1 NC_008769.1 hypothetical protein 299594 4698239 BCG_0263c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976361.1 297864 R 410289 CDS YP_976362.1 121636139 4698794 complement(299604..300869) 1 NC_008769.1 Differs from Rv0227c by 1aa, R29S, and from Mb0232c by 1aa, S392N; hypothetical protein 300869 4698794 BCG_0264c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976362.1 299604 R 410289 CDS YP_976363.1 121636140 4698221 301085..302308 1 NC_008769.1 integral membrane acyltransferase 302308 4698221 BCG_0265 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane acyltransferase YP_976363.1 301085 D 410289 CDS YP_976364.1 121636141 4698790 complement(302336..303016) 1 NC_008769.1 hypothetical protein 303016 4698790 BCG_0266c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976364.1 302336 R 410289 CDS YP_976365.1 121636142 4695383 complement(303013..303993) 1 NC_008769.1 Differs from Rv0230c by 1aa, E199D; phosphotriesterase PHP 303993 php 4695383 php Mycobacterium bovis BCG str. Pasteur 1173P2 phosphotriesterase PHP YP_976365.1 303013 R 410289 CDS YP_976366.1 121636143 4697037 304088..305794 1 NC_008769.1 acyl-CoA dehydrogenase fadE4 305794 fadE4 4697037 fadE4 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE4 YP_976366.1 304088 D 410289 CDS YP_976367.1 121636144 4696255 305929..306618 1 NC_008769.1 TetR family transcriptional regulator 306618 4696255 BCG_0269 Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_976367.1 305929 D 410289 CDS YP_976368.1 121636145 4695750 306615..307559 1 NC_008769.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit beta 307559 nrdB 4695750 nrdB Mycobacterium bovis BCG str. Pasteur 1173P2 ribonucleotide-diphosphate reductase subunit beta YP_976368.1 306615 D 410289 CDS YP_976369.1 121636146 4698713 complement(307635..309170) 1 NC_008769.1 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinate-semialdehyde dehydrogenase 309170 gabD1 4698713 gabD1 Mycobacterium bovis BCG str. Pasteur 1173P2 succinate-semialdehyde dehydrogenase YP_976369.1 307635 R 410289 CDS YP_976370.1 121636147 4695548 complement(309196..310644) 1 NC_008769.1 hypothetical protein 310644 4695548 BCG_0272c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976370.1 309196 R 410289 CDS YP_976371.1 121636148 4698499 complement(310679..314881) 1 NC_008769.1 Differs from Rv0236c by 3aa, V412M, A990T, G1080S; hypothetical protein 314881 4698499 BCG_0273c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976371.1 310679 R 410289 CDS YP_976372.1 121636149 4698021 complement(314928..315101) 1 NC_008769.1 hypothetical protein 315101 4698021 BCG_0274c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976372.1 314928 R 410289 CDS YP_976373.1 121636150 4698823 315216..316382 1 NC_008769.1 Differs from Rv0237 by 1aa, L129V; lipoprotein lpqI 316382 lpqI 4698823 lpqI Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqI YP_976373.1 315216 D 410289 CDS YP_976374.1 121636151 4698156 316458..317072 1 NC_008769.1 TetR family transcriptional regulator 317072 4698156 BCG_0276 Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_976374.1 316458 D 410289 CDS YP_976375.1 121636152 4696734 317134..317367 1 NC_008769.1 hypothetical protein 317367 4696734 BCG_0277 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976375.1 317134 D 410289 CDS YP_976376.1 121636153 4698779 317375..317812 1 NC_008769.1 Differs from Rv0240 by 1aa, S31A; hypothetical protein 317812 4698779 BCG_0278 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976376.1 317375 D 410289 CDS YP_976377.1 121636154 4698015 complement(317842..318684) 1 NC_008769.1 hypothetical protein 318684 4698015 BCG_0279c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976377.1 317842 R 410289 CDS YP_976378.1 121636155 4695780 complement(318695..320059) 1 NC_008769.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 320059 fabG 4695780 fabG Mycobacterium bovis BCG str. Pasteur 1173P2 3-ketoacyl-ACP reductase YP_976378.1 318695 R 410289 CDS YP_976379.1 121636156 4697071 320201..321523 1 NC_008769.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 321523 fadA2 4697071 fadA2 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-CoA acetyltransferase YP_976379.1 320201 D 410289 CDS YP_976380.1 121636157 4698442 complement(321829..323664) 1 NC_008769.1 Differs from Mb0250c by 1aa, N503D and from Rv0244c by 3aa, R394K, A479E, N503D; acyl-CoA dehydrogenase fadE5 323664 fadE5 4698442 fadE5 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE5 YP_976380.1 321829 R 410289 CDS YP_976381.1 121636158 4696256 324036..324524 1 NC_008769.1 oxidoreductase 324524 4696256 BCG_0283 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_976381.1 324036 D 410289 CDS YP_976382.1 121636159 4698092 324840..326150 1 NC_008769.1 Differs from Rv0246 by 1aa, A129V; integral membrane protein 326150 4698092 BCG_0284 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_976382.1 324840 D 410289 CDS YP_976383.1 121636160 4698720 complement(326147..326893) 1 NC_008769.1 catalyzes the fumarate and succinate interconversion; fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source; fumarate reductase iron-sulfur subunit 326893 4698720 BCG_0285c Mycobacterium bovis BCG str. Pasteur 1173P2 fumarate reductase iron-sulfur subunit YP_976383.1 326147 R 410289 CDS YP_976384.1 121636161 4695826 complement(326894..328834) 1 NC_008769.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 328834 sdhA 4695826 sdhA Mycobacterium bovis BCG str. Pasteur 1173P2 succinate dehydrogenase flavoprotein subunit YP_976384.1 326894 R 410289 CDS YP_976385.1 121636162 4696782 complement(328865..329686) 1 NC_008769.1 succinate dehydrogenase membrane anchor subunit 329686 4696782 BCG_0287c Mycobacterium bovis BCG str. Pasteur 1173P2 succinate dehydrogenase membrane anchor subunit YP_976385.1 328865 R 410289 CDS YP_976386.1 121636163 4697759 complement(329766..330059) 1 NC_008769.1 hypothetical protein 330059 4697759 BCG_0288c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976386.1 329766 R 410289 CDS YP_976387.1 121636164 4695359 complement(330204..330683) 1 NC_008769.1 heat shock protein hsp 330683 hsp 4695359 hsp Mycobacterium bovis BCG str. Pasteur 1173P2 heat shock protein hsp YP_976387.1 330204 R 410289 CDS YP_976388.1 121636165 4697339 330897..333458 1 NC_008769.1 nitrite reductase NAD(P)H] large subunit 333458 nirB 4697339 nirB Mycobacterium bovis BCG str. Pasteur 1173P2 nitrite reductase NAD(P)H] large subunit YP_976388.1 330897 D 410289 CDS YP_976389.1 121636166 4699206 333484..333840 1 NC_008769.1 nitrite reductase [NAD(P)H] small subunit nirD 333840 nirD 4699206 nirD Mycobacterium bovis BCG str. Pasteur 1173P2 nitrite reductase [NAD(P)H] small subunit nirD YP_976389.1 333484 D 410289 CDS YP_976390.1 121636167 4699207 complement(333856..334380) 1 NC_008769.1 bifunctional cobalamin biosynthesis protein cobU: cobinamide kinase + cobinamide phosphate guanylyltransferase 334380 cobU 4699207 cobU Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional cobalamin biosynthesis protein cobU: cobinamide kinase + cobinamide phosphate guanylyltransferase YP_976390.1 333856 R 410289 CDS YP_976391.1 121636168 4697940 complement(334405..335889) 1 NC_008769.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation; cobyric acid synthase 335889 cobQ1 4697940 cobQ1 Mycobacterium bovis BCG str. Pasteur 1173P2 cobyric acid synthase YP_976391.1 334405 R 410289 CDS YP_976392.1 121636169 4698555 complement(335908..337578) 1 NC_008769.1 PPE family protein 337578 PPE2 4698555 PPE2 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_976392.1 335908 R 410289 CDS YP_976393.1 121636170 4697069 337886..338104 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transition (c-t) leads to a truncated product in the 5' direction compared to Mycobacterium tuberculosis strain H37Rv (72 aa versus 124 aa); hypothetical protein 338104 4697069 BCG_0295 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976393.1 337886 D 410289 CDS YP_976394.1 121636171 4695376 complement(338325..338780) 1 NC_008769.1 hypothetical protein 338780 4695376 BCG_0296c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976394.1 338325 R 410289 CDS YP_976395.1 121636172 4698229 complement(338805..339548) 1 NC_008769.1 Differs from Rv0259c by 1aa, V182A; hypothetical protein 339548 4698229 BCG_0297c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976395.1 338805 R 410289 CDS YP_976396.1 121636173 4699345 complement(339545..340690) 1 NC_008769.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; bifunctional uroporphyrinogen-III synthetase/response regulator domain-containing protein 340690 4699345 BCG_0298c Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional uroporphyrinogen-III synthetase/response regulator domain-containing protein YP_976396.1 339545 R 410289 CDS YP_976397.1 121636174 4698915 complement(340790..342199) 1 NC_008769.1 integral membrane nitrite extrusion protein narK3 342199 narK3 4698915 narK3 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane nitrite extrusion protein narK3 YP_976397.1 340790 R 410289 CDS YP_976398.1 121636175 4697467 complement(342340..342885) 1 NC_008769.1 aminoglycoside 2'-n-acetyltransferase aac 342885 aac 4697467 aac Mycobacterium bovis BCG str. Pasteur 1173P2 aminoglycoside 2'-n-acetyltransferase aac YP_976398.1 342340 R 410289 CDS YP_976399.1 121636176 4698700 complement(342895..343797) 1 NC_008769.1 hypothetical protein 343797 4698700 BCG_0301c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976399.1 342895 R 410289 CDS YP_976400.1 121636177 4699153 complement(343814..344446) 1 NC_008769.1 hypothetical protein 344446 4699153 BCG_0302c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976400.1 343814 R 410289 CDS YP_976401.1 121636178 4697220 complement(344542..345534) 1 NC_008769.1 Differs from Rv0265c and Mb0271c by 1aa, C313Y; periplasmic iron-transport lipoprotein 345534 4697220 BCG_0303c Mycobacterium bovis BCG str. Pasteur 1173P2 periplasmic iron-transport lipoprotein YP_976401.1 344542 R 410289 CDS YP_976402.1 121636179 4695900 complement(345556..349185) 1 NC_008769.1 5-oxoprolinase 349185 oplA 4695900 oplA Mycobacterium bovis BCG str. Pasteur 1173P2 5-oxoprolinase YP_976402.1 345556 R 410289 CDS YP_976403.1 121636180 4698680 349362..350753 1 NC_008769.1 integral membrane nitrite extrusion protein narU 350753 narU 4698680 narU Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane nitrite extrusion protein narU YP_976403.1 349362 D 410289 CDS YP_976404.1 121636181 4697469 complement(350795..351304) 1 NC_008769.1 hypothetical protein 351304 4697469 BCG_0306c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976404.1 350795 R 410289 CDS YP_976405.1 121636182 4698669 complement(351369..352562) 1 NC_008769.1 hypothetical protein 352562 4698669 BCG_0307c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976405.1 351369 R 410289 CDS YP_976406.1 121636183 4698035 352598..354280 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 354280 fadD2 4698035 fadD2 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_976406.1 352598 D 410289 CDS YP_976407.1 121636184 4695420 complement(354297..356492) 1 NC_008769.1 acyl-CoA dehydrogenase fadE6 356492 fadE6 4695420 fadE6 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE6 YP_976407.1 354297 R 410289 CDS YP_976408.1 121636185 4696257 complement(356606..357739) 1 NC_008769.1 Differs from Mb0278c by 1aa, P164L; hypothetical protein 357739 4696257 BCG_0310c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976408.1 356606 R 410289 CDS YP_976409.1 121636186 4697726 complement(357736..358356) 1 NC_008769.1 transcriptional regulatory protein 358356 4697726 BCG_0311c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976409.1 357736 R 410289 CDS YP_976410.1 121636187 4697690 358453..359034 1 NC_008769.1 hypothetical protein 359034 4697690 BCG_0312 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976410.1 358453 D 410289 CDS YP_976411.1 121636188 4699312 complement(358964..359689) 1 NC_008769.1 Differs from Rv0275c by 1aa, L24S; TetR family transcriptional regulator 359689 4699312 BCG_0313c Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_976411.1 358964 R 410289 CDS YP_976412.1 121636189 4697725 359779..360699 1 NC_008769.1 hypothetical protein 360699 4697725 BCG_0314 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976412.1 359779 D 410289 CDS YP_976413.1 121636190 4696359 complement(360739..361167) 1 NC_008769.1 hypothetical protein 361167 4696359 BCG_0315c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976413.1 360739 R 410289 CDS YP_976414.1 121636191 4697964 complement(361191..361448) 1 NC_008769.1 Differs by 1 aa, Q24* from Rv0227A and Mb0351A; antitoxin 361448 4697964 BCG_0315A Mycobacterium bovis BCG str. Pasteur 1173P2 antitoxin YP_976414.1 361191 R 410289 CDS YP_976415.1 121636192 4697094 complement(361533..364283) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS3 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovs BCG Pasteur, a large insertion leads to an extra copy of PE_PGRS3. Also, a frameshift due to single base deletion (t-*), splits this extra copy of PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b. Also differs from Mb0285c by an insertion of 144bp; PE-PGRS family protein 364283 PE_PGRS3a 4697094 PE_PGRS3a Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_976415.1 361533 R 410289 CDS YP_976416.1 121636193 4697093 complement(364547..367246) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, a insertion of 66 bp lead to a longer product than to the homolog Mycobacterium bovis (899 aa versus 877 aa). In Mycobacterium bovis, 2 deletions, one of 18 bp and the other of 66 bp, and part of a 2780 bp insertion , leads to a shorter product with a different 3' end compared to its homolog in Mycobacterium tuberculosis strain H37Rv (877 aa versus 957 aa); PE-PGRS family protein 367246 PE_PGRS3 4697093 PE_PGRS3 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_976416.1 364547 R 410289 CDS YP_976417.1 121636194 4696182 complement(367496..370000) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, 2 insertions each of 9 bp and a deletion of 9bp, lead to a longer product compared to its homolog in Mycobacterium bovis (834 aa versus 831 aa). In Mycobacterium bovis, 2 deletions each of 9 bp (ccgccggcg-* and cccgccggc-*), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (831 aa versus 837 aa); PE-PGRS family protein 370000 PE_PGRS4 4696182 PE_PGRS4 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_976417.1 367496 R 410289 CDS YP_976418.1 121636195 4697095 370291..371901 1 NC_008769.1 Differs from Rv0280 by 1 aa P337S; PPE family protein 371901 PPE3 4697095 PPE3 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_976418.1 370291 D 410289 CDS YP_976419.1 121636196 4697685 371925..372833 1 NC_008769.1 hypothetical protein 372833 4697685 BCG_0321 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976419.1 371925 D 410289 CDS YP_976420.1 121636197 4697218 373058..374953 1 NC_008769.1 Differs from Rv0282 by 1aa, A6E; hypothetical protein 374953 4697218 BCG_0322 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976420.1 373058 D 410289 CDS YP_976421.1 121636198 4697294 374950..376566 1 NC_008769.1 hypothetical protein 376566 4697294 BCG_0323 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976421.1 374950 D 410289 CDS YP_976422.1 121636199 4696654 376563..380555 1 NC_008769.1 Differs from Mb0292 by 1aa, A134T, and from Rv0284 by 2aa, A134T, R214P; hypothetical protein 380555 4696654 BCG_0324 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976422.1 376563 D 410289 CDS YP_976423.1 121636200 4698280 380552..380860 1 NC_008769.1 PE family protein 380860 PE5 4698280 PE5 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_976423.1 380552 D 410289 CDS YP_976424.1 121636201 4696202 380863..382404 1 NC_008769.1 PPE family protein 382404 PPE4 4696202 PPE4 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_976424.1 380863 D 410289 CDS YP_976425.1 121636202 4697818 382453..382746 1 NC_008769.1 hypothetical protein 382746 esxG 4697818 esxG Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976425.1 382453 D 410289 CDS YP_976426.1 121636203 4698781 382776..383066 1 NC_008769.1 low molecular weight protein antigen 7 cfp7 383066 esxH 4698781 esxH Mycobacterium bovis BCG str. Pasteur 1173P2 low molecular weight protein antigen 7 cfp7 YP_976426.1 382776 D 410289 CDS YP_976427.1 121636204 4698809 383077..383964 1 NC_008769.1 hypothetical protein 383964 4698809 BCG_0329 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976427.1 383077 D 410289 CDS YP_976428.1 121636205 4698139 384011..385429 1 NC_008769.1 Differs from Rv0290 by 1aa, T400A; hypothetical protein 385429 4698139 BCG_0330 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976428.1 384011 D 410289 CDS YP_976429.1 121636206 4699096 385426..386811 1 NC_008769.1 protease 386811 4699096 BCG_0331 Mycobacterium bovis BCG str. Pasteur 1173P2 protease YP_976429.1 385426 D 410289 CDS YP_976430.1 121636207 4698120 386808..387803 1 NC_008769.1 Differs from Rv0292 by 1aa, D217N; hypothetical protein 387803 4698120 BCG_0332 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976430.1 386808 D 410289 CDS YP_976431.1 121636208 4695810 complement(387790..388992) 1 NC_008769.1 Differs from Rv0293c and Mb0301c by 1aa, S263G; hypothetical protein 388992 4695810 BCG_0333c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976431.1 387790 R 410289 CDS YP_976432.1 121636209 4696893 389099..389884 1 NC_008769.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 389884 tam 4696893 tam Mycobacterium bovis BCG str. Pasteur 1173P2 trans-aconitate 2-methyltransferase YP_976432.1 389099 D 410289 CDS YP_976433.1 121636210 4696339 complement(389873..390676) 1 NC_008769.1 hypothetical protein 390676 4696339 BCG_0335c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976433.1 389873 R 410289 CDS YP_976434.1 121636211 4697957 complement(390686..392083) 1 NC_008769.1 sulfatase 392083 4697957 BCG_0336c Mycobacterium bovis BCG str. Pasteur 1173P2 sulfatase YP_976434.1 390686 R 410289 CDS YP_976435.1 121636212 4697403 392262..394082 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (606 aa versus 591 aa); PE-PGRS family protein 394082 PE_PGRS5 4697403 PE_PGRS5 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_976435.1 392262 D 410289 CDS YP_976436.1 121636213 4695718 394225..394452 1 NC_008769.1 hypothetical protein 394452 4695718 BCG_0338 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976436.1 394225 D 410289 CDS YP_976437.1 121636214 4698968 394449..394751 1 NC_008769.1 Differs from Mb0307 by 1aa, S13N; hypothetical protein 394751 4698968 BCG_0339 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976437.1 394449 D 410289 CDS YP_976438.1 121636215 4698642 394799..395020 1 NC_008769.1 hypothetical protein 395020 4698642 BCG_0340 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976438.1 394799 D 410289 CDS YP_976439.1 121636216 4698422 395017..395442 1 NC_008769.1 hypothetical protein 395442 4698422 BCG_0341 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976439.1 395017 D 410289 CDS YP_976440.1 121636217 4695467 395579..396211 1 NC_008769.1 Differs from Mb0310 by 1aa A124V; TetR family transcriptional regulator 396211 4695467 BCG_0342 Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_976440.1 395579 D 410289 CDS YP_976441.1 121636218 4697256 396208..397116 1 NC_008769.1 dehydrogenase/reductase 397116 4697256 BCG_0343 Mycobacterium bovis BCG str. Pasteur 1173P2 dehydrogenase/reductase YP_976441.1 396208 D 410289 CDS YP_976442.1 121636219 4697219 complement(397124..400567) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (g-*) leads to a shorter CDS (Mb0312c and BCG_0344c) equivalent to the 3' end of Rv0304c/PPE5. Differs from Rv0304c by 3aa, S481G, F708S, A955T, and 5 codon in-frame deletion at position 503; PPE family protein 400567 PPE5 4697219 PPE5 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_976442.1 397124 R 410289 CDS YP_976443.1 121636220 4696876 complement(400711..406638) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (t-*) resulting in the absence of a stop codon leads to a longer product. The second part of this CDS shares homology with the 5' end of Rv0304c/PPE5. Differs from Mb0313c by in-frame deletion of 10 codons; PPE family protein 406638 PPE6 4696876 PPE6 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_976443.1 400711 R 410289 CDS YP_976444.1 121636221 4698215 406841..407512 1 NC_008769.1 oxidoreductase 407512 4698215 BCG_0346 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_976444.1 406841 D 410289 CDS YP_976445.1 121636222 4695774 complement(407500..407982) 1 NC_008769.1 hypothetical protein 407982 4695774 BCG_0347c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976445.1 407500 R 410289 CDS YP_976446.1 121636223 4697716 408040..408756 1 NC_008769.1 integral membrane protein 408756 4697716 BCG_0348 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_976446.1 408040 D 410289 CDS YP_976447.1 121636224 4698232 408858..409514 1 NC_008769.1 hypothetical protein 409514 4698232 BCG_0349 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976447.1 408858 D 410289 CDS YP_976448.1 121636225 4695402 complement(409584..410075) 1 NC_008769.1 hypothetical protein 410075 4695402 BCG_0350c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976448.1 409584 R 410289 CDS YP_976449.1 121636226 4698435 410099..411328 1 NC_008769.1 hypothetical protein 411328 4698435 BCG_0351 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976449.1 410099 D 410289 CDS YP_976450.1 121636227 4698919 411483..413345 1 NC_008769.1 Differs from Rv0312 by 2aa, G159S, L563P; hypothetical protein 413345 4698919 BCG_0352 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976450.1 411483 D 410289 CDS YP_976451.1 121636228 4697371 413417..413803 1 NC_008769.1 hypothetical protein 413803 4697371 BCG_0353 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976451.1 413417 D 410289 CDS YP_976452.1 121636229 4697400 complement(413806..414468) 1 NC_008769.1 Differs from Rv0314c by 1aa, A184V; hypothetical protein 414468 4697400 BCG_0354c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976452.1 413806 R 410289 CDS YP_976453.1 121636230 4697754 414529..415413 1 NC_008769.1 Differs from Rv0315 by 1aa, T260K; beta-1,3-glucanase 415413 4697754 BCG_0355 Mycobacterium bovis BCG str. Pasteur 1173P2 beta-1,3-glucanase YP_976453.1 414529 D 410289 CDS YP_976454.1 121636231 4695701 415462..416076 1 NC_008769.1 muconolactone isomerase 416076 4695701 BCG_0356 Mycobacterium bovis BCG str. Pasteur 1173P2 muconolactone isomerase YP_976454.1 415462 D 410289 CDS YP_976455.1 121636232 4698721 complement(416100..416870) 1 NC_008769.1 glycerophosphoryl diester phosphodiesterase glpQ2 416870 glpQ2 4698721 glpQ2 Mycobacterium bovis BCG str. Pasteur 1173P2 glycerophosphoryl diester phosphodiesterase glpQ2 YP_976455.1 416100 R 410289 CDS YP_976456.1 121636233 4696329 complement(417232..418026) 1 NC_008769.1 Differs from Rv0318c by 1aa, A223G; integral membrane protein 418026 4696329 BCG_0358c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_976456.1 417232 R 410289 CDS YP_976457.1 121636234 4696347 418075..418743 1 NC_008769.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 418743 pcp 4696347 pcp Mycobacterium bovis BCG str. Pasteur 1173P2 pyrrolidone-carboxylate peptidase YP_976457.1 418075 D 410289 CDS YP_976458.1 121636235 4698420 418815..419477 1 NC_008769.1 hypothetical protein 419477 4698420 BCG_0360 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976458.1 418815 D 410289 CDS YP_976459.1 121636236 4697227 419509..420081 1 NC_008769.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 420081 dcd 4697227 dcd Mycobacterium bovis BCG str. Pasteur 1173P2 deoxycytidine triphosphate deaminase YP_976459.1 419509 D 410289 CDS YP_976460.1 121636237 4697262 420187..421518 1 NC_008769.1 udp-glucose 6-dehydrogenase udgA 421518 udgA 4697262 udgA Mycobacterium bovis BCG str. Pasteur 1173P2 udp-glucose 6-dehydrogenase udgA YP_976460.1 420187 D 410289 CDS YP_976461.1 121636238 4696865 complement(421507..422178) 1 NC_008769.1 Differs from Rv0323c by 1aa, G142S; hypothetical protein 422178 4696865 BCG_0363c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976461.1 421507 R 410289 CDS YP_976462.1 121636239 4696364 422279..422959 1 NC_008769.1 Differs from Rv0324 by 1aa, A168T; ArsR family transcriptional regulator 422959 4696364 BCG_0364 Mycobacterium bovis BCG str. Pasteur 1173P2 ArsR family transcriptional regulator YP_976462.1 422279 D 410289 CDS YP_976463.1 121636240 4695771 422966..423655 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv0325 and Rv0326 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, the absence of a stop codon between Rv0325 and Rv0326 due to a single base transition (t-c) leads to single product; hypothetical protein 423655 4695771 BCG_0365 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976463.1 422966 D 410289 CDS YP_976464.1 121636241 4698342 complement(423623..424972) 1 NC_008769.1 Differs from Rv0327c by 1aa, Y100H; cytochrome P450 135A1 cyp135A1 424972 cyp135A1 4698342 cyp135A1 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome P450 135A1 cyp135A1 YP_976464.1 423623 R 410289 CDS YP_976465.1 121636242 4697064 425038..425640 1 NC_008769.1 TetR family transcriptional regulator 425640 4697064 BCG_0367 Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_976465.1 425038 D 410289 CDS YP_976466.1 121636243 4696759 complement(425621..426247) 1 NC_008769.1 Differs from Rv0329c by 1aa, S129W; hypothetical protein 426247 4696759 BCG_0368c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976466.1 425621 R 410289 CDS YP_976467.1 121636244 4697221 complement(426274..427014) 1 NC_008769.1 hypothetical protein 427014 4697221 BCG_0369c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976467.1 426274 R 410289 CDS YP_976468.1 121636245 4698412 427128..428294 1 NC_008769.1 dehydrogenase/reductase 428294 4698412 BCG_0370 Mycobacterium bovis BCG str. Pasteur 1173P2 dehydrogenase/reductase YP_976468.1 427128 D 410289 CDS YP_976469.1 121636246 4696350 428369..429154 1 NC_008769.1 Differs from Rv0332 by 1aa, G198E; hypothetical protein 429154 4696350 BCG_0371 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976469.1 428369 D 410289 CDS YP_976470.1 121636247 4697767 429181..429555 1 NC_008769.1 hypothetical protein 429555 4697767 BCG_0372 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976470.1 429181 D 410289 CDS YP_976471.1 121636248 4696702 429585..430451 1 NC_008769.1 glucose-1-phosphate thymidylyltransferase rmlA 430451 rmlA 4696702 rmlA Mycobacterium bovis BCG str. Pasteur 1173P2 glucose-1-phosphate thymidylyltransferase rmlA YP_976471.1 429585 D 410289 CDS YP_976472.1 121636249 4695583 complement(430462..430977) 1 NC_008769.1 Differs from Rv0335c and Mb0340 by 1aa P131T; PE family protein 430977 PE6 4695583 PE6 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_976472.1 430462 R 410289 CDS YP_976473.1 121636250 4696203 431119..432630 1 NC_008769.1 Differs from Rv0336 by 1aa, H496P; hypothetical protein 432630 4696203 BCG_0375 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976473.1 431119 D 410289 CDS YP_976474.1 121636251 4697963 complement(432800..434089) 1 NC_008769.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 434089 aspC 4697963 aspC Mycobacterium bovis BCG str. Pasteur 1173P2 aminotransferase YP_976474.1 432800 R 410289 CDS YP_976475.1 121636252 4695459 complement(434120..436768) 1 NC_008769.1 Differs from Rv0338c by 2aa, G506R, V621A; iron-sulfur-binding reductase 436768 4695459 BCG_0377c Mycobacterium bovis BCG str. Pasteur 1173P2 iron-sulfur-binding reductase YP_976475.1 434120 R 410289 CDS YP_976476.1 121636253 4695752 complement(436877..439375) 1 NC_008769.1 transcriptional regulatory protein 439375 4695752 BCG_0378c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976476.1 436877 R 410289 CDS YP_976477.1 121636254 4697829 439561..440100 1 NC_008769.1 hypothetical protein 440100 4697829 BCG_0379 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976477.1 439561 D 410289 CDS YP_976478.1 121636255 4699344 440289..441728 1 NC_008769.1 isoniazid inductible gene protein iniB 441728 iniB 4699344 iniB Mycobacterium bovis BCG str. Pasteur 1173P2 isoniazid inductible gene protein iniB YP_976478.1 440289 D 410289 CDS YP_976479.1 121636256 4697078 441765..443687 1 NC_008769.1 Differs from by 2aa, S88N, Q481H; isoniazid inductible gene protein iniA 443687 iniA 4697078 iniA Mycobacterium bovis BCG str. Pasteur 1173P2 isoniazid inductible gene protein iniA YP_976479.1 441765 D 410289 CDS YP_976480.1 121636257 4697077 443684..445165 1 NC_008769.1 isoniazid inductible gene protein iniC 445165 iniC 4697077 iniC Mycobacterium bovis BCG str. Pasteur 1173P2 isoniazid inductible gene protein iniC YP_976480.1 443684 D 410289 CDS YP_976481.1 121636258 4697432 complement(445308..445868) 1 NC_008769.1 lipoprotein lpqJ 445868 lpqJ 4697432 lpqJ Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqJ YP_976481.1 445308 R 410289 CDS YP_976482.1 121636259 4698157 445977..446387 1 NC_008769.1 In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv in Mycobacterium bovis BCG Pasteur; hypothetical protein 446387 4698157 BCG_0384 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976482.1 445977 D 410289 CDS YP_976483.1 121636260 4695803 complement(446429..447892) 1 NC_008769.1 l-asparagine permease ansP2 447892 ansP2 4695803 ansP2 Mycobacterium bovis BCG str. Pasteur 1173P2 l-asparagine permease ansP2 YP_976483.1 446429 R 410289 CDS YP_976484.1 121636261 4697141 448231..449217 1 NC_008769.1 hypothetical protein 449217 4697141 BCG_0386 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976484.1 448231 D 410289 CDS YP_976485.1 121636262 4695384 449220..449873 1 NC_008769.1 transcriptional regulatory protein 449873 4695384 BCG_0387 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976485.1 449220 D 410289 CDS YP_976486.1 121636263 4695917 449876..450535 1 NC_008769.1 hypothetical protein 450535 4695917 BCG_0388 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976486.1 449876 D 410289 CDS YP_976487.1 121636264 4697869 450762..452639 1 NC_008769.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 452639 dnaK 4697869 dnaK Mycobacterium bovis BCG str. Pasteur 1173P2 molecular chaperone DnaK YP_976487.1 450762 D 410289 CDS YP_976488.1 121636265 4699017 452636..453343 1 NC_008769.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 453343 grpE 4699017 grpE Mycobacterium bovis BCG str. Pasteur 1173P2 heat shock protein GrpE YP_976488.1 452636 D 410289 CDS YP_976489.1 121636266 4697812 453379..454566 1 NC_008769.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 454566 dnaJ1 4697812 dnaJ1 Mycobacterium bovis BCG str. Pasteur 1173P2 chaperone protein DnaJ YP_976489.1 453379 D 410289 CDS YP_976490.1 121636267 4699347 454566..454946 1 NC_008769.1 heat shock protein transcriptional regulator HspR 454946 hspR 4699347 hspR Mycobacterium bovis BCG str. Pasteur 1173P2 heat shock protein transcriptional regulator HspR YP_976490.1 454566 D 410289 CDS YP_976491.1 121636268 4696301 complement(454969..465492) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PPE7 and PPE8 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 2 bp insertion (*-ta) resulting in the absence of a stop codon between the 2 genes, leads to a single product, and an altered C-terminus; PPE family protein 465492 PPE8 4696301 PPE8 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_976491.1 454969 R 410289 CDS YP_976492.1 121636269 4696417 complement(465643..466287) 1 NC_008769.1 hypothetical protein 466287 4696417 BCG_0394c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976492.1 465643 R 410289 CDS YP_976493.1 121636270 4696674 complement(466284..467582) 1 NC_008769.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 467582 purA 4696674 purA Mycobacterium bovis BCG str. Pasteur 1173P2 adenylosuccinate synthetase YP_976493.1 466284 R 410289 CDS YP_976494.1 121636271 4699225 467673..468320 1 NC_008769.1 hypothetical protein 468320 4699225 BCG_0396 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976494.1 467673 D 410289 CDS YP_976495.1 121636272 4697373 468331..469110 1 NC_008769.1 Differs from Rv0359 by 1aa, T252A; integral membrane protein 469110 4697373 BCG_0397 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_976495.1 468331 D 410289 CDS YP_976496.1 121636273 4696939 complement(469115..469552) 1 NC_008769.1 hypothetical protein 469552 4696939 BCG_0398c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976496.1 469115 R 410289 CDS YP_976497.1 121636274 4696308 469635..470462 1 NC_008769.1 hypothetical protein 470462 4696308 BCG_0399 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976497.1 469635 D 410289 CDS YP_976498.1 121636275 4695690 470684..472066 1 NC_008769.1 Differs from Rv0362 by 1aa, V292A; Mg2+ transport transmembrane protein mgtE 472066 mgtE 4695690 mgtE Mycobacterium bovis BCG str. Pasteur 1173P2 Mg2+ transport transmembrane protein mgtE YP_976498.1 470684 D 410289 CDS YP_976499.1 121636276 4699000 complement(472078..473112) 1 NC_008769.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 473112 fba 4699000 fba Mycobacterium bovis BCG str. Pasteur 1173P2 fructose-bisphosphate aldolase YP_976499.1 472078 R 410289 CDS YP_976500.1 121636277 4695684 473208..473891 1 NC_008769.1 Differs from Rv0364 by 1aa, L193I; hypothetical protein 473891 4695684 BCG_0402 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976500.1 473208 D 410289 CDS YP_976501.1 121636278 4695525 complement(473880..475010) 1 NC_008769.1 hypothetical protein 475010 4695525 BCG_0403c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976501.1 473880 R 410289 CDS YP_976502.1 121636279 4695589 complement(475035..475628) 1 NC_008769.1 hypothetical protein 475628 4695589 BCG_0404c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976502.1 475035 R 410289 CDS YP_976503.1 121636280 4698009 complement(475657..476046) 1 NC_008769.1 hypothetical protein 476046 4698009 BCG_0405c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976503.1 475657 R 410289 CDS YP_976504.1 121636281 4695835 complement(476127..477338) 1 NC_008769.1 Differs from Rv0368c by 1aa, H249R, and from Mb0375c by 1aa, G371S; hypothetical protein 477338 4695835 BCG_0406c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976504.1 476127 R 410289 CDS YP_976505.1 121636282 4695431 complement(477344..477859) 1 NC_008769.1 membrane oxidoreductase 477859 4695431 BCG_0407c Mycobacterium bovis BCG str. Pasteur 1173P2 membrane oxidoreductase YP_976505.1 477344 R 410289 CDS YP_976506.1 121636283 4697476 complement(477960..478856) 1 NC_008769.1 Differs from Rv0370c by 1aa, E201G; oxidoreductase 478856 4697476 BCG_0408c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_976506.1 477960 R 410289 CDS YP_976507.1 121636284 4696983 complement(478853..479446) 1 NC_008769.1 hypothetical protein 479446 4696983 BCG_0409c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976507.1 478853 R 410289 CDS YP_976508.1 121636285 4695369 complement(479443..480198) 1 NC_008769.1 Differs from Rv0372c by 1aa, G161S; hypothetical protein 480198 4695369 BCG_0410c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976508.1 479443 R 410289 CDS YP_976509.1 121636286 4696547 complement(480217..482616) 1 NC_008769.1 Differs from Rv0373c by 1aa, S122F; carbon monoxyde dehydrogenase large chain 482616 4696547 BCG_0411c Mycobacterium bovis BCG str. Pasteur 1173P2 carbon monoxyde dehydrogenase large chain YP_976509.1 480217 R 410289 CDS YP_976510.1 121636287 4696006 complement(482613..483092) 1 NC_008769.1 carbon monoxyde dehydrogenase small chain 483092 4696006 BCG_0412c Mycobacterium bovis BCG str. Pasteur 1173P2 carbon monoxyde dehydrogenase small chain YP_976510.1 482613 R 410289 CDS YP_976511.1 121636288 4696726 complement(483107..483967) 1 NC_008769.1 carbon monoxyde dehydrogenase medium chain 483967 4696726 BCG_0413c Mycobacterium bovis BCG str. Pasteur 1173P2 carbon monoxyde dehydrogenase medium chain YP_976511.1 483107 R 410289 CDS YP_976512.1 121636289 4697103 complement(484043..485185) 1 NC_008769.1 hypothetical protein 485185 4697103 BCG_0414c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976512.1 484043 R 410289 CDS YP_976513.1 121636290 4696588 485234..486199 1 NC_008769.1 Differs from Rv0377 by 1aa, R302P; LysR family transcriptional regulator 486199 4696588 BCG_0415 Mycobacterium bovis BCG str. Pasteur 1173P2 LysR family transcriptional regulator YP_976513.1 485234 D 410289 CDS YP_976514.1 121636291 4697455 486450..486671 1 NC_008769.1 hypothetical protein 486671 4697455 BCG_0416 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976514.1 486450 D 410289 CDS YP_976515.1 121636292 4697673 486790..487005 1 NC_008769.1 protein transport protein secE2 487005 secE2 4697673 secE2 Mycobacterium bovis BCG str. Pasteur 1173P2 protein transport protein secE2 YP_976515.1 486790 D 410289 CDS YP_976516.1 121636293 4697708 complement(487081..487632) 1 NC_008769.1 rna methyltransferase 487632 4697708 BCG_0418c Mycobacterium bovis BCG str. Pasteur 1173P2 rna methyltransferase YP_976516.1 487081 R 410289 CDS YP_976517.1 121636294 4697216 complement(487728..488636) 1 NC_008769.1 hypothetical protein 488636 4697216 BCG_0419c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976517.1 487728 R 410289 CDS YP_976518.1 121636295 4697528 complement(488654..489193) 1 NC_008769.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 489193 pyrE 4697528 pyrE Mycobacterium bovis BCG str. Pasteur 1173P2 orotate phosphoribosyltransferase YP_976518.1 488654 R 410289 CDS YP_976519.1 121636296 4697784 complement(489274..490128) 1 NC_008769.1 hypothetical protein 490128 4697784 BCG_0421c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976519.1 489274 R 410289 CDS YP_976520.1 121636297 4697361 complement(490269..492815) 1 NC_008769.1 endopeptidase ATP binding protein subunit B 492815 clpB 4697361 clpB Mycobacterium bovis BCG str. Pasteur 1173P2 endopeptidase ATP binding protein subunit B YP_976520.1 490269 R 410289 CDS YP_976521.1 121636298 4697010 492948..494120 1 NC_008769.1 monooxygenase 494120 4697010 BCG_0423 Mycobacterium bovis BCG str. Pasteur 1173P2 monooxygenase YP_976521.1 492948 D 410289 CDS YP_976522.1 121636299 4697702 494224..497481 1 NC_008769.1 Differs from Mb0393 by 1aa, D902A; LuxR family transcriptional regulator 497481 4697702 BCG_0424 Mycobacterium bovis BCG str. Pasteur 1173P2 LuxR family transcriptional regulator YP_976522.1 494224 D 410289 CDS YP_976523.1 121636300 4696958 complement(497485..498816) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv0388c and Rv0387c exist as 2 separate genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, 3 different base substitutions, the first of 14 bases, the second of 8 bases (tctacagt-gctacagg), and lastly of 28 bases, leads to a longer single product; Differs from Mb0394c by 1aa, T361A; PPE family protein 498816 PPE9 4696958 PPE9 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_976523.1 497485 R 410289 CDS YP_976524.1 121636301 4696418 499150..500409 1 NC_008769.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 500409 purT 4696418 purT Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoribosylglycinamide formyltransferase 2 YP_976524.1 499150 D 410289 CDS YP_976525.1 121636302 4696059 500406..500828 1 NC_008769.1 hypothetical protein 500828 4696059 BCG_0427 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976525.1 500406 D 410289 CDS YP_976526.1 121636303 4696910 500825..502045 1 NC_008769.1 O-succinylhomoserine sulfhydrylase 502045 metZ 4696910 metZ Mycobacterium bovis BCG str. Pasteur 1173P2 O-succinylhomoserine sulfhydrylase YP_976526.1 500825 D 410289 CDS YP_976527.1 121636304 4699106 complement(502042..503454) 1 NC_008769.1 Differs from Rv0392c by 1aa, A241V; membrane NADH dehydrogenase ndhA 503454 ndhA 4699106 ndhA Mycobacterium bovis BCG str. Pasteur 1173P2 membrane NADH dehydrogenase ndhA YP_976527.1 502042 R 410289 CDS YP_976528.1 121636305 4696138 503596..504921 1 NC_008769.1 hypothetical protein 504921 4696138 BCG_0430 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976528.1 503596 D 410289 CDS YP_976529.1 121636306 4697365 complement(504937..505656) 1 NC_008769.1 hypothetical protein 505656 4697365 BCG_0431c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976529.1 504937 R 410289 CDS YP_976530.1 121636307 4696421 505755..506159 1 NC_008769.1 Differs from Rv0395 by 1aa, A80V; hypothetical protein 506159 4696421 BCG_0432 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976530.1 505755 D 410289 CDS YP_976531.1 121636308 4696027 506165..506557 1 NC_008769.1 hypothetical protein 506557 4696027 BCG_0433 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976531.1 506165 D 410289 CDS YP_976532.1 121636309 4695980 506631..506999 1 NC_008769.1 hypothetical protein 506999 4695980 BCG_0434 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976532.1 506631 D 410289 CDS YP_976533.1 121636310 4697139 complement(507494..508135) 1 NC_008769.1 hypothetical protein 508135 4697139 BCG_0435c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976533.1 507494 R 410289 CDS YP_976534.1 121636311 4695965 complement(508142..509371) 1 NC_008769.1 lipoprotein lpqK 509371 lpqK 4695965 lpqK Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqK YP_976534.1 508142 R 410289 CDS YP_976535.1 121636312 4698158 complement(509381..510568) 1 NC_008769.1 acyl-CoA dehydrogenase fadE7 510568 fadE7 4698158 fadE7 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE7 YP_976535.1 509381 R 410289 CDS YP_976536.1 121636313 4696258 510604..510975 1 NC_008769.1 hypothetical protein 510975 4696258 BCG_0438 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976536.1 510604 D 410289 CDS YP_976537.1 121636314 4697008 complement(511170..512273) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b; transmembrane transport protein mmpL1b 512273 mmpL1b 4697008 mmpL1b Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane transport protein mmpL1b YP_976537.1 511170 R 410289 CDS YP_976538.1 121636315 4695519 complement(512270..514045) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b; Differs from Rv0402c by 1aa, P451L; transmembrane transport protein mmpL1a 514045 mmpL1a 4695519 mmpL1a Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane transport protein mmpL1a YP_976538.1 512270 R 410289 CDS YP_976539.1 121636316 4695518 complement(514042..514470) 1 NC_008769.1 membrane protein mmpS1 514470 mmpS1 4695518 mmpS1 Mycobacterium bovis BCG str. Pasteur 1173P2 membrane protein mmpS1 YP_976539.1 514042 R 410289 CDS YP_976540.1 121636317 4697490 514791..516548 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 516548 fadD30 4697490 fadD30 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_976540.1 514791 D 410289 CDS YP_976541.1 121636318 4699138 516545..517927 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to single base insertion (*-g) splits pks6 into 2 parts, pks6a and pks6b; membrane bound polyketide synthase pks6a 517927 pks6a 4699138 pks6a Mycobacterium bovis BCG str. Pasteur 1173P2 membrane bound polyketide synthase pks6a YP_976541.1 516545 D 410289 CDS YP_976542.1 121636319 4696577 517914..520754 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis, a frameshift due to single base insertion (*-g), splits pks6 into 2 parts, pks6a and pks6b; Differs from Mb0413 by 1aa, M921V; membrane bound polyketide synthase pks6b 520754 pks6b 4696577 pks6b Mycobacterium bovis BCG str. Pasteur 1173P2 membrane bound polyketide synthase pks6b YP_976542.1 517914 D 410289 CDS YP_976543.1 121636320 4696578 complement(520702..521520) 1 NC_008769.1 beta-lactamase 521520 4696578 BCG_0445c Mycobacterium bovis BCG str. Pasteur 1173P2 beta-lactamase YP_976543.1 520702 R 410289 CDS YP_976544.1 121636321 4696963 521598..522608 1 NC_008769.1 glucose-6-phosphate dehydrogenase 522608 fgd1 4696963 fgd1 Mycobacterium bovis BCG str. Pasteur 1173P2 glucose-6-phosphate dehydrogenase YP_976544.1 521598 D 410289 CDS YP_976545.1 121636322 4695793 522601..524673 1 NC_008769.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 524673 pta 4695793 pta Mycobacterium bovis BCG str. Pasteur 1173P2 phosphate acetyltransferase YP_976545.1 522601 D 410289 CDS YP_976546.1 121636323 4697315 524666..525823 1 NC_008769.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 525823 ackA 4697315 ackA Mycobacterium bovis BCG str. Pasteur 1173P2 acetate kinase YP_976546.1 524666 D 410289 CDS YP_976547.1 121636324 4698962 complement(525877..528129) 1 NC_008769.1 Serine/threonine-protein kinase pknG 528129 pknG 4698962 pknG Mycobacterium bovis BCG str. Pasteur 1173P2 Serine/threonine-protein kinase pknG YP_976547.1 525877 R 410289 CDS YP_976548.1 121636325 4697522 complement(528129..529115) 1 NC_008769.1 glutamine-binding lipoprotein glnH 529115 glnH 4697522 glnH Mycobacterium bovis BCG str. Pasteur 1173P2 glutamine-binding lipoprotein glnH YP_976548.1 528129 R 410289 CDS YP_976549.1 121636326 4697947 complement(529115..530434) 1 NC_008769.1 Differs from Rv0412c by 1aa, Y355D; hypothetical protein 530434 4697947 BCG_0451c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976549.1 529115 R 410289 CDS YP_976550.1 121636327 4696193 530528..531181 1 NC_008769.1 mutator protein MutT3 531181 mutT3 4696193 mutT3 Mycobacterium bovis BCG str. Pasteur 1173P2 mutator protein MutT3 YP_976550.1 530528 D 410289 CDS YP_976551.1 121636328 4695711 complement(531165..531833) 1 NC_008769.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 531833 thiE 4695711 thiE Mycobacterium bovis BCG str. Pasteur 1173P2 thiamine-phosphate pyrophosphorylase YP_976551.1 531165 R 410289 CDS YP_976552.1 121636329 4695451 531963..532985 1 NC_008769.1 Differs from Rv0415 by 1aa, A158V; thiamine biosynthesis oxidoreductase thiO 532985 thiO 4695451 thiO Mycobacterium bovis BCG str. Pasteur 1173P2 thiamine biosynthesis oxidoreductase thiO YP_976552.1 531963 D 410289 CDS YP_976553.1 121636330 4697958 532982..533188 1 NC_008769.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 533188 thiS 4697958 thiS Mycobacterium bovis BCG str. Pasteur 1173P2 sulfur carrier protein ThiS YP_976553.1 532982 D 410289 CDS YP_976554.1 121636331 4697959 533181..533939 1 NC_008769.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 533939 thiG 4697959 thiG Mycobacterium bovis BCG str. Pasteur 1173P2 thiazole synthase YP_976554.1 533181 D 410289 CDS YP_976555.1 121636332 4695452 534311..535813 1 NC_008769.1 lipoprotein aminopeptidase lpqL 535813 lpqL 4695452 lpqL Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein aminopeptidase lpqL YP_976555.1 534311 D 410289 CDS YP_976556.1 121636333 4698190 535901..537397 1 NC_008769.1 Differs from Rv0419 by 2aa, T73A, T297A, and from Mb0427 by 1aa, T73A; lipoprotein peptidase lpqM 537397 lpqM 4698190 lpqM Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein peptidase lpqM YP_976556.1 535901 D 410289 CDS YP_976557.1 121636334 4698191 complement(537376..537786) 1 NC_008769.1 Differs from Rv0420c by 1aa, G21E; hypothetical protein 537786 4698191 BCG_0459c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976557.1 537376 R 410289 CDS YP_976558.1 121636335 4695996 complement(537947..538576) 1 NC_008769.1 hypothetical protein 538576 4695996 BCG_0460c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976558.1 537947 R 410289 CDS YP_976559.1 121636336 4696047 complement(538573..539370) 1 NC_008769.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 539370 thiD 4696047 thiD Mycobacterium bovis BCG str. Pasteur 1173P2 phosphomethylpyrimidine kinase YP_976559.1 538573 R 410289 CDS YP_976560.1 121636337 4695450 complement(539397..541040) 1 NC_008769.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 541040 thiC 4695450 thiC Mycobacterium bovis BCG str. Pasteur 1173P2 thiamine biosynthesis protein ThiC YP_976560.1 539397 R 410289 CDS YP_976561.1 121636338 4695449 complement(541192..541467) 1 NC_008769.1 hypothetical protein 541467 4695449 BCG_0463c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976561.1 541192 R 410289 CDS YP_976562.1 121636339 4697004 complement(541517..546136) 1 NC_008769.1 Differs from Rv0425c by 1aa, A222E; metal cation transporting P-type atpase ctpH 546136 ctpH 4697004 ctpH Mycobacterium bovis BCG str. Pasteur 1173P2 metal cation transporting P-type atpase ctpH YP_976562.1 541517 R 410289 CDS YP_976563.1 121636340 4695617 complement(546188..546631) 1 NC_008769.1 hypothetical protein 546631 4695617 BCG_0465c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976563.1 546188 R 410289 CDS YP_976564.1 121636341 4696947 complement(546832..547707) 1 NC_008769.1 exodeoxyribonuclease III protein xthA 547707 xthA 4696947 xthA Mycobacterium bovis BCG str. Pasteur 1173P2 exodeoxyribonuclease III protein xthA YP_976564.1 546832 R 410289 CDS YP_976565.1 121636342 4697557 complement(547710..548618) 1 NC_008769.1 Differs from Rv0428c by 1aa G149D; hypothetical protein 548618 4697557 BCG_0467c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976565.1 547710 R 410289 CDS YP_976566.1 121636343 4696950 complement(548618..549211) 1 NC_008769.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 549211 def 4696950 def Mycobacterium bovis BCG str. Pasteur 1173P2 peptide deformylase YP_976566.1 548618 R 410289 CDS YP_976567.1 121636344 4698670 549548..549856 1 NC_008769.1 hypothetical protein 549856 4698670 BCG_0469 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976567.1 549548 D 410289 CDS YP_976568.1 121636345 4696932 549888..550382 1 NC_008769.1 Differs from Rv0431 by 2aa, G38V, A87T; tuberculin-like protein 550382 4696932 BCG_0470 Mycobacterium bovis BCG str. Pasteur 1173P2 tuberculin-like protein YP_976568.1 549888 D 410289 CDS YP_976569.1 121636346 4697120 550415..551137 1 NC_008769.1 periplasmic superoxide dismutase [Cu-Zn] sodC 551137 sodC 4697120 sodC Mycobacterium bovis BCG str. Pasteur 1173P2 periplasmic superoxide dismutase [Cu-Zn] sodC YP_976569.1 550415 D 410289 CDS YP_976570.1 121636347 4695621 551139..552269 1 NC_008769.1 ATP-dependent carboxylate-amine ligase; carboxylate-amine ligase 552269 4695621 BCG_0472 Mycobacterium bovis BCG str. Pasteur 1173P2 carboxylate-amine ligase YP_976570.1 551139 D 410289 CDS YP_976571.1 121636348 4696913 552329..552982 1 NC_008769.1 Differs from Rv0434 by 1aa, A190T; hypothetical protein 552982 4696913 BCG_0473 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976571.1 552329 D 410289 CDS YP_976572.1 121636349 4695865 complement(553162..555348) 1 NC_008769.1 atpase 555348 4695865 BCG_0474c Mycobacterium bovis BCG str. Pasteur 1173P2 atpase YP_976572.1 553162 R 410289 CDS YP_976573.1 121636350 4697100 complement(555345..556205) 1 NC_008769.1 Differs from Rv0436c by 1aa, V167G; CDP-diacylglycerol--serine o-phosphatidyltransferase pssA 556205 pssA 4697100 pssA Mycobacterium bovis BCG str. Pasteur 1173P2 CDP-diacylglycerol--serine o-phosphatidyltransferase pssA YP_976573.1 555345 R 410289 CDS YP_976574.1 121636351 4696824 complement(556202..556897) 1 NC_008769.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase 556897 psd 4696824 psd Mycobacterium bovis BCG str. Pasteur 1173P2 phosphatidylserine decarboxylase YP_976574.1 556202 R 410289 CDS YP_976575.1 121636352 4697279 complement(556958..558175) 1 NC_008769.1 Differs from Rv0438c by 1aa, I15M; molybdopterin biosynthesis protein moeA2 558175 moeA2 4697279 moeA2 Mycobacterium bovis BCG str. Pasteur 1173P2 molybdopterin biosynthesis protein moeA2 YP_976575.1 556958 R 410289 CDS YP_976576.1 121636353 4697171 complement(558194..559129) 1 NC_008769.1 short chain dehydrogenase 559129 4697171 BCG_0478c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_976576.1 558194 R 410289 CDS YP_976577.1 121636354 4697235 559423..561045 1 NC_008769.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 561045 groEL 4697235 groEL Mycobacterium bovis BCG str. Pasteur 1173P2 chaperonin GroEL YP_976577.1 559423 D 410289 CDS YP_976578.1 121636355 4698395 complement(561111..561539) 1 NC_008769.1 hypothetical protein 561539 4698395 BCG_0480c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976578.1 561111 R 410289 CDS YP_976579.1 121636356 4696548 complement(561566..563005) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transition (g-a) creates an in-frame stop at codon 8, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (479 aa versus 487 aa). Differs from Mb0450c by 1aa, T214K, and from Rv0442c by 2aa, E23K, T214K; PPE family protein 563005 PPE10 4696548 PPE10 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_976579.1 561566 R 410289 CDS YP_976580.1 121636357 4696161 563211..563726 1 NC_008769.1 hypothetical protein 563726 4696161 BCG_0482 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976580.1 563211 D 410289 CDS YP_976581.1 121636358 4696024 complement(563906..564604) 1 NC_008769.1 Differs from Rv0444c by 2aa, D107G, E184G; hypothetical protein 564604 4696024 BCG_0483c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976581.1 563906 R 410289 CDS YP_976582.1 121636359 4697108 complement(564648..565211) 1 NC_008769.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins; RNA polymerase sigma factor SigK 565211 sigK 4697108 sigK Mycobacterium bovis BCG str. Pasteur 1173P2 RNA polymerase sigma factor SigK YP_976582.1 564648 R 410289 CDS YP_976583.1 121636360 4696443 complement(565260..566030) 1 NC_008769.1 hypothetical protein 566030 4696443 BCG_0485c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976583.1 565260 R 410289 CDS YP_976584.1 121636361 4697593 complement(566039..567322) 1 NC_008769.1 cyclopropane-fatty-acyl-phospholipid synthase ufaA1 567322 ufaA1 4697593 ufaA1 Mycobacterium bovis BCG str. Pasteur 1173P2 cyclopropane-fatty-acyl-phospholipid synthase ufaA1 YP_976584.1 566039 R 410289 CDS YP_976585.1 121636362 4696866 complement(567319..567984) 1 NC_008769.1 hypothetical protein 567984 4696866 BCG_0487c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976585.1 567319 R 410289 CDS YP_976586.1 121636363 4696611 complement(568044..569363) 1 NC_008769.1 hypothetical protein 569363 4696611 BCG_0488c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976586.1 568044 R 410289 CDS YP_976587.1 121636364 4697364 complement(569403..572306) 1 NC_008769.1 Differs from Mb0458c by 1aa, A314T; transmembrane transport protein mmpL4 572306 mmpL4 4697364 mmpL4 Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane transport protein mmpL4 YP_976587.1 569403 R 410289 CDS YP_976588.1 121636365 4695522 complement(572303..572725) 1 NC_008769.1 membrane protein mmpS4 572725 mmpS4 4695522 mmpS4 Mycobacterium bovis BCG str. Pasteur 1173P2 membrane protein mmpS4 YP_976588.1 572303 R 410289 CDS YP_976589.1 121636366 4697493 572957..573667 1 NC_008769.1 transcriptional regulatory protein 573667 4697493 BCG_0491 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976589.1 572957 D 410289 CDS YP_976590.1 121636367 4696019 573989..575545 1 NC_008769.1 PPE family protein 575545 PPE11 4696019 PPE11 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_976590.1 573989 D 410289 CDS YP_976591.1 121636368 4696162 575650..576000 1 NC_008769.1 hypothetical protein 576000 4696162 BCG_0493 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976591.1 575650 D 410289 CDS YP_976592.1 121636369 4697757 complement(576190..576636) 1 NC_008769.1 hypothetical protein 576636 4697757 BCG_0494c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976592.1 576190 R 410289 CDS YP_976593.1 121636370 4695981 complement(576704..577618) 1 NC_008769.1 catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 577618 echA2 4695981 echA2 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_976593.1 576704 R 410289 CDS YP_976594.1 121636371 4697927 complement(577891..578172) 1 NC_008769.1 hypothetical protein 578172 4697927 BCG_0496c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976594.1 577891 R 410289 CDS YP_976595.1 121636372 4696285 complement(578401..580431) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG, a possible RBS upstream leads to an earlier start resulting in a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (676 aa versus 673 aa); peptidase 580431 4696285 BCG_0497c Mycobacterium bovis BCG str. Pasteur 1173P2 peptidase YP_976595.1 578401 R 410289 CDS YP_976596.1 121636373 4696960 580490..582013 1 NC_008769.1 aldehyde dehydrogenase 582013 4696960 BCG_0498 Mycobacterium bovis BCG str. Pasteur 1173P2 aldehyde dehydrogenase YP_976596.1 580490 D 410289 CDS YP_976597.1 121636374 4696311 582013..582504 1 NC_008769.1 hypothetical protein 582504 4696311 BCG_0499 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976597.1 582013 D 410289 CDS YP_976598.1 121636375 4695663 582564..582803 1 NC_008769.1 hypothetical protein 582803 4695663 BCG_0500 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976598.1 582564 D 410289 CDS YP_976599.1 121636376 4695991 582841..583365 1 NC_008769.1 hypothetical protein 583365 4695991 BCG_0501 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976599.1 582841 D 410289 CDS YP_976600.1 121636377 4696921 583429..584823 1 NC_008769.1 E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; dihydrolipoamide dehydrogenase 584823 lpd 4696921 lpd Mycobacterium bovis BCG str. Pasteur 1173P2 dihydrolipoamide dehydrogenase YP_976600.1 583429 D 410289 CDS YP_976601.1 121636378 4695787 584831..585124 1 NC_008769.1 hypothetical protein 585124 4695787 BCG_0503 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976601.1 584831 D 410289 CDS YP_976602.1 121636379 4696021 complement(585128..585700) 1 NC_008769.1 hypothetical protein 585700 4696021 BCG_0504c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976602.1 585128 R 410289 CDS YP_976603.1 121636380 4695978 complement(585697..587121) 1 NC_008769.1 Differs from Rv0465c by 2aa, D36N, R106C, and from Mb0474c by 1aa, R326Q; transcriptional regulatory protein 587121 4695978 BCG_0505c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976603.1 585697 R 410289 CDS YP_976604.1 121636381 4696015 587273..588067 1 NC_008769.1 hypothetical protein 588067 4696015 BCG_0506 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976604.1 587273 D 410289 CDS YP_976605.1 121636382 4696942 588342..589628 1 NC_008769.1 isocitrate lyase icl 589628 icl 4696942 icl Mycobacterium bovis BCG str. Pasteur 1173P2 isocitrate lyase icl YP_976605.1 588342 D 410289 CDS YP_976606.1 121636383 4699215 589710..590570 1 NC_008769.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase 590570 fadB2 4699215 fadB2 Mycobacterium bovis BCG str. Pasteur 1173P2 3-hydroxybutyryl-CoA dehydrogenase YP_976606.1 589710 D 410289 CDS YP_976607.1 121636384 4698840 590703..591563 1 NC_008769.1 mycolic acid synthase umaA1 591563 umaA1 4698840 umaA1 Mycobacterium bovis BCG str. Pasteur 1173P2 mycolic acid synthase umaA1 YP_976607.1 590703 D 410289 CDS YP_976608.1 121636385 4696500 complement(591663..592526) 1 NC_008769.1 mycolic acid synthase PcaA 592526 pcaA 4696500 pcaA Mycobacterium bovis BCG str. Pasteur 1173P2 mycolic acid synthase PcaA YP_976608.1 591663 R 410289 CDS YP_976609.1 121636386 4698836 complement(592669..593109) 1 NC_008769.1 hypothetical protein 593109 4698836 BCG_0511c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976609.1 592669 R 410289 CDS YP_976610.1 121636387 4697054 complement(593040..593528) 1 NC_008769.1 hypothetical protein 593528 4697054 BCG_0512c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976610.1 593040 R 410289 CDS YP_976611.1 121636388 4697053 complement(593538..594242) 1 NC_008769.1 Differs from Rv0472c and Mb0482c by 1aa, D162G; TetR family transcriptional regulator 594242 4697053 BCG_0513c Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_976611.1 593538 R 410289 CDS YP_976612.1 121636389 4696920 594379..595749 1 NC_008769.1 Differs from Rv0473 by 1aa, R5K; hypothetical protein 595749 4696920 BCG_0514 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976612.1 594379 D 410289 CDS YP_976613.1 121636390 4696029 595836..596258 1 NC_008769.1 transcriptional regulatory protein 596258 4696029 BCG_0515 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976613.1 595836 D 410289 CDS YP_976614.1 121636391 4696475 596612..597211 1 NC_008769.1 Heparin binding hemagglutinin hbhA 597211 hbhA 4696475 hbhA Mycobacterium bovis BCG str. Pasteur 1173P2 Heparin binding hemagglutinin hbhA YP_976614.1 596612 D 410289 CDS YP_976615.1 121636392 4695480 597323..597586 1 NC_008769.1 hypothetical protein 597586 4695480 BCG_0517 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976615.1 597323 D 410289 CDS YP_976616.1 121636393 4695961 597591..598037 1 NC_008769.1 hypothetical protein 598037 4695961 BCG_0518 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976616.1 597591 D 410289 CDS YP_976617.1 121636394 4696966 598037..598711 1 NC_008769.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 598711 deoC 4696966 deoC Mycobacterium bovis BCG str. Pasteur 1173P2 deoxyribose-phosphate aldolase YP_976617.1 598037 D 410289 CDS YP_976618.1 121636395 4698988 complement(598736..599782) 1 NC_008769.1 hypothetical protein 599782 4698988 BCG_0520c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976618.1 598736 R 410289 CDS YP_976619.1 121636396 4696965 complement(599779..600714) 1 NC_008769.1 In Mycobacterium bovis, a 56 bp deletion results in a different NH2 part and leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (311 aa versus 340 aa); hypothetical protein 600714 4696965 BCG_0521c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976619.1 599779 R 410289 CDS YP_976620.1 121636397 4696954 complement(600747..601271) 1 NC_008769.1 hypothetical protein 601271 4696954 BCG_0522c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976620.1 600747 R 410289 CDS YP_976621.1 121636398 4696005 601298..602407 1 NC_008769.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 602407 murB 4696005 murB Mycobacterium bovis BCG str. Pasteur 1173P2 UDP-N-acetylenolpyruvoylglucosamine reductase YP_976621.1 601298 D 410289 CDS YP_976622.1 121636399 4699152 602469..603824 1 NC_008769.1 lipoprotein lprQ 603824 lprQ 4699152 lprQ Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lprQ YP_976622.1 602469 D 410289 CDS YP_976623.1 121636400 4697257 complement(603805..604560) 1 NC_008769.1 Differs from Rv0484c by 1aa, L140I; short-chain type oxidoreductase 604560 4697257 BCG_0525c Mycobacterium bovis BCG str. Pasteur 1173P2 short-chain type oxidoreductase YP_976623.1 603805 R 410289 CDS YP_976624.1 121636401 4696156 604743..606059 1 NC_008769.1 transcriptional regulatory protein 606059 4696156 BCG_0526 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976624.1 604743 D 410289 CDS YP_976625.1 121636402 4696986 606107..607549 1 NC_008769.1 mannosyltransferase 607549 4696986 BCG_0527 Mycobacterium bovis BCG str. Pasteur 1173P2 mannosyltransferase YP_976625.1 606107 D 410289 CDS YP_976626.1 121636403 4696048 607546..608097 1 NC_008769.1 hypothetical protein 608097 4696048 BCG_0528 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976626.1 607546 D 410289 CDS YP_976627.1 121636404 4696914 608539..609144 1 NC_008769.1 integral membrane protein 609144 4696914 BCG_0529 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_976627.1 608539 D 410289 CDS YP_976628.1 121636405 4696951 609301..610050 1 NC_008769.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 610050 gpmA 4696951 gpmA Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoglyceromutase YP_976628.1 609301 D 410289 CDS YP_976629.1 121636406 4697840 610224..611456 1 NC_008769.1 Differs from Rv0490 and Mb0500 by 1aa, S109F; two component sensor histidine kinase senX3 611456 senX3 4697840 senX3 Mycobacterium bovis BCG str. Pasteur 1173P2 two component sensor histidine kinase senX3 YP_976629.1 610224 D 410289 CDS YP_976630.1 121636407 4697882 611607..612290 1 NC_008769.1 Differs from Rv0491 and Mb0501 by 1aa, T18A; two component sensory transduction protein RegX3 612290 regX3 4697882 regX3 Mycobacterium bovis BCG str. Pasteur 1173P2 two component sensory transduction protein RegX3 YP_976630.1 611607 D 410289 CDS YP_976631.1 121636408 4695842 complement(612287..614176) 1 NC_008769.1 Differs from Rv0492c by 1aa, F520L; oxidoreductase GMC-type 614176 4695842 BCG_0533c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase GMC-type YP_976631.1 612287 R 410289 CDS YP_976632.1 121636409 4697132 complement(614173..614502) 1 NC_008769.1 hypothetical protein 614502 4697132 BCG_0534c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976632.1 614173 R 410289 CDS YP_976633.1 121636410 4697063 complement(614499..615488) 1 NC_008769.1 Differs from Rv0493c by 1aa, G174S; hypothetical protein 615488 4697063 BCG_0535c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976633.1 614499 R 410289 CDS YP_976634.1 121636411 4695972 615493..616221 1 NC_008769.1 GntR family transcriptional regulator 616221 4695972 BCG_0536 Mycobacterium bovis BCG str. Pasteur 1173P2 GntR family transcriptional regulator YP_976634.1 615493 D 410289 CDS YP_976635.1 121636412 4696044 complement(616222..617112) 1 NC_008769.1 hypothetical protein 617112 4696044 BCG_0537c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976635.1 616222 R 410289 CDS YP_976636.1 121636413 4695967 617192..618178 1 NC_008769.1 hypothetical protein 618178 4695967 BCG_0538 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976636.1 617192 D 410289 CDS YP_976637.1 121636414 4696468 618175..619107 1 NC_008769.1 hypothetical protein 619107 4696468 BCG_0539 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976637.1 618175 D 410289 CDS YP_976638.1 121636415 4695575 619123..619965 1 NC_008769.1 hypothetical protein 619965 4695575 BCG_0540 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976638.1 619123 D 410289 CDS YP_976639.1 121636416 4696935 619981..620856 1 NC_008769.1 hypothetical protein 620856 4696935 BCG_0541 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976639.1 619981 D 410289 CDS YP_976640.1 121636417 4696151 620881..621768 1 NC_008769.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 621768 proC 4696151 proC Mycobacterium bovis BCG str. Pasteur 1173P2 pyrroline-5-carboxylate reductase YP_976640.1 620881 D 410289 CDS YP_976641.1 121636418 4696514 621909..622145 1 NC_008769.1 hypothetical protein 622145 4696514 BCG_0543 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976641.1 621909 D 410289 CDS YP_976642.1 121636419 4695969 622452..623582 1 NC_008769.1 udp-glucose 4-epimerase galE2 623582 galE2 4695969 galE2 Mycobacterium bovis BCG str. Pasteur 1173P2 udp-glucose 4-epimerase galE2 YP_976642.1 622452 D 410289 CDS YP_976643.1 121636420 4695531 623589..624665 1 NC_008769.1 hypothetical protein 624665 4695531 BCG_0545 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976643.1 623589 D 410289 CDS YP_976644.1 121636421 4696917 complement(624669..625577) 1 NC_008769.1 cyclopropane-fatty-acyl-phospholipid synthase 2 cmaA2 625577 cmaA2 4696917 cmaA2 Mycobacterium bovis BCG str. Pasteur 1173P2 cyclopropane-fatty-acyl-phospholipid synthase 2 cmaA2 YP_976644.1 624669 R 410289 CDS YP_976645.1 121636422 4698572 complement(625600..626100) 1 NC_008769.1 hypothetical protein 626100 4698572 BCG_0547c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976645.1 625600 R 410289 CDS YP_976646.1 121636423 4695979 complement(626262..627383) 1 NC_008769.1 phosphoserine phosphatase serB1 627383 serB1 4695979 serB1 Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoserine phosphatase serB1 YP_976646.1 626262 R 410289 CDS YP_976647.1 121636424 4696249 627557..628000 1 NC_008769.1 membrane protein mmpS2 628000 mmpS2 4696249 mmpS2 Mycobacterium bovis BCG str. Pasteur 1173P2 membrane protein mmpS2 YP_976647.1 627557 D 410289 CDS YP_976648.1 121636425 4697491 627997..630903 1 NC_008769.1 Differs from Mb0519 by 1aa, D119H, and from Rv0507 by 3aa, H426R, Y509D, C722S; transmembrane transport protein mmpL2 630903 mmpL2 4697491 mmpL2 Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane transport protein mmpL2 YP_976648.1 627997 D 410289 CDS YP_976649.1 121636426 4695520 630896..631189 1 NC_008769.1 hypothetical protein 631189 4695520 BCG_0551 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976649.1 630896 D 410289 CDS YP_976650.1 121636427 4696020 631239..632645 1 NC_008769.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 632645 hemA 4696020 hemA Mycobacterium bovis BCG str. Pasteur 1173P2 glutamyl-tRNA reductase YP_976650.1 631239 D 410289 CDS YP_976651.1 121636428 4695483 632655..633584 1 NC_008769.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 633584 hemC 4695483 hemC Mycobacterium bovis BCG str. Pasteur 1173P2 porphobilinogen deaminase YP_976651.1 632655 D 410289 CDS YP_976652.1 121636429 4698902 633617..635314 1 NC_008769.1 uroporphyrin-III c-methyltransferase hemD 635314 hemD 4698902 hemD Mycobacterium bovis BCG str. Pasteur 1173P2 uroporphyrin-III c-methyltransferase hemD YP_976652.1 633617 D 410289 CDS YP_976653.1 121636430 4698903 635400..636389 1 NC_008769.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 636389 hemB 4698903 hemB Mycobacterium bovis BCG str. Pasteur 1173P2 delta-aminolevulinic acid dehydratase YP_976653.1 635400 D 410289 CDS YP_976654.1 121636431 4698901 636402..636950 1 NC_008769.1 hypothetical protein 636950 4698901 BCG_0556 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976654.1 636402 D 410289 CDS YP_976655.1 121636432 4696980 636947..637246 1 NC_008769.1 Differs from Mb0527 and Rv0514 by 1aa, G23A; hypothetical protein 637246 4696980 BCG_0557 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976655.1 636947 D 410289 CDS YP_976656.1 121636433 4696170 637349..638860 1 NC_008769.1 hypothetical protein 638860 4696170 BCG_0558 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976656.1 637349 D 410289 CDS YP_976657.1 121636434 4696072 complement(638857..639333) 1 NC_008769.1 hypothetical protein 639333 4696072 BCG_0559c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976657.1 638857 R 410289 CDS YP_976658.1 121636435 4695960 639544..640854 1 NC_008769.1 Differs from Rv0517 by 1aa, G394D; membrane acyltransferase 640854 4695960 BCG_0560 Mycobacterium bovis BCG str. Pasteur 1173P2 membrane acyltransferase YP_976658.1 639544 D 410289 CDS YP_976659.1 121636436 4697161 640986..641681 1 NC_008769.1 hypothetical protein 641681 4697161 BCG_0561 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976659.1 640986 D 410289 CDS YP_976660.1 121636437 4695968 complement(641970..642872) 1 NC_008769.1 hypothetical protein 642872 4695968 BCG_0562c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976660.1 641970 R 410289 CDS YP_976661.1 121636438 4696025 643053..643403 1 NC_008769.1 methyltransferase/methylase 643403 4696025 BCG_0563 Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase/methylase YP_976661.1 643053 D 410289 CDS YP_976662.1 121636439 4696929 643396..643701 1 NC_008769.1 methyltransferase/methylase 643701 4696929 BCG_0564 Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase/methylase YP_976662.1 643396 D 410289 CDS YP_976663.1 121636440 4695677 643836..645140 1 NC_008769.1 4-amino butyrate transport carrier 645140 gabP 4695677 gabP Mycobacterium bovis BCG str. Pasteur 1173P2 4-amino butyrate transport carrier YP_976663.1 643836 D 410289 CDS YP_976664.1 121636441 4695550 complement(645124..645519) 1 NC_008769.1 hypothetical protein 645519 4695550 BCG_0566c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976664.1 645124 R 410289 CDS YP_976665.1 121636442 4695466 645633..647021 1 NC_008769.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 647021 hemL 4695466 hemL Mycobacterium bovis BCG str. Pasteur 1173P2 glutamate-1-semialdehyde aminotransferase YP_976665.1 645633 D 410289 CDS YP_976666.1 121636443 4698929 647021..647629 1 NC_008769.1 hypothetical protein 647629 4698929 BCG_0568 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976666.1 647021 D 410289 CDS YP_976667.1 121636444 4696922 647644..648294 1 NC_008769.1 thioredoxin protein 648294 4696922 BCG_0569 Mycobacterium bovis BCG str. Pasteur 1173P2 thioredoxin protein YP_976667.1 647644 D 410289 CDS YP_976668.1 121636445 4696927 648291..649070 1 NC_008769.1 cytochrome c-type biogenesis protein ccdA 649070 ccdA 4696927 ccdA Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome c-type biogenesis protein ccdA YP_976668.1 648291 D 410289 CDS YP_976669.1 121636446 4698483 649103..650692 1 NC_008769.1 hypothetical protein 650692 4698483 BCG_0571 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976669.1 649103 D 410289 CDS YP_976670.1 121636447 4695986 650689..651663 1 NC_008769.1 cytochrome c-type biogenesis protein ccsA 651663 ccsA 4695986 ccsA Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome c-type biogenesis protein ccsA YP_976670.1 650689 D 410289 CDS YP_976671.1 121636448 4695462 651705..652922 1 NC_008769.1 hypothetical protein 652922 4695462 BCG_0573 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976671.1 651705 D 410289 CDS YP_976672.1 121636449 4695929 653127..653444 1 NC_008769.1 hypothetical protein 653444 4695929 BCG_0574 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976672.1 653127 D 410289 CDS YP_976673.1 121636450 4695964 653591..655336 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS6 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-t) splits PE_PGRS6 into 2 parts, PE_PGRS6a and PE_PGRS6b, resulting in PE_PGRS6a having a different COOH part. There is also a 84 bp and a 9 bp (*-cggggccgg) insertion in PE_PGRS6a; PE-PGRS family protein 655336 PE_PGRS6a 4695964 PE_PGRS6a Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_976673.1 653591 D 410289 CDS YP_976674.1 121636451 4696988 complement(655365..656372) 1 NC_008769.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 656372 fabH 4696988 fabH Mycobacterium bovis BCG str. Pasteur 1173P2 3-oxoacyl-ACP synthase YP_976674.1 655365 R 410289 CDS YP_976675.1 121636452 4697865 complement(656454..657332) 1 NC_008769.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 657332 menA 4697865 menA Mycobacterium bovis BCG str. Pasteur 1173P2 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_976675.1 656454 R 410289 CDS YP_976676.1 121636453 4696704 657349..658143 1 NC_008769.1 Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate; 5'-methylthioadenosine phosphorylase 658143 pnp 4696704 pnp Mycobacterium bovis BCG str. Pasteur 1173P2 5'-methylthioadenosine phosphorylase YP_976676.1 657349 D 410289 CDS YP_976677.1 121636454 4696816 658140..659180 1 NC_008769.1 UDP-glucose 4-epimerase 659180 galE3 4696816 galE3 Mycobacterium bovis BCG str. Pasteur 1173P2 UDP-glucose 4-epimerase YP_976677.1 658140 D 410289 CDS YP_976678.1 121636455 4695532 complement(659190..660623) 1 NC_008769.1 integral membrane protein 660623 4695532 BCG_0581c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_976678.1 659190 R 410289 CDS YP_976679.1 121636456 4697755 660932..662578 1 NC_008769.1 Differs from Rv0538 by 1aa, P228R; hypothetical protein 662578 4697755 BCG_0582 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976679.1 660932 D 410289 CDS YP_976680.1 121636457 4696938 662635..663267 1 NC_008769.1 dolichyl-phosphate sugar synthase 663267 4696938 BCG_0583 Mycobacterium bovis BCG str. Pasteur 1173P2 dolichyl-phosphate sugar synthase YP_976680.1 662635 D 410289 CDS YP_976681.1 121636458 4696873 663264..663926 1 NC_008769.1 hypothetical protein 663926 4696873 BCG_0584 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976681.1 663264 D 410289 CDS YP_976682.1 121636459 4695636 complement(663947..665296) 1 NC_008769.1 Differs from Rv0541c by 1aa, V226I; integral membrane protein 665296 4695636 BCG_0585c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_976682.1 663947 R 410289 CDS YP_976683.1 121636460 4695870 complement(665308..666396) 1 NC_008769.1 O-succinylbenzoic acid--CoA ligase 666396 menE 4695870 menE Mycobacterium bovis BCG str. Pasteur 1173P2 O-succinylbenzoic acid--CoA ligase YP_976683.1 665308 R 410289 CDS YP_976684.1 121636461 4696112 complement(666465..666767) 1 NC_008769.1 hypothetical protein 666767 4696112 BCG_0587c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976684.1 666465 R 410289 CDS YP_976685.1 121636462 4695966 complement(666827..667105) 1 NC_008769.1 hypothetical protein 667105 4695966 BCG_0588c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976685.1 666827 R 410289 CDS YP_976686.1 121636463 4695987 complement(667102..668355) 1 NC_008769.1 Differs from Rv0545c by 1aa, S49P; low-affinity inorganic phosphate transporter integral membrane protein pitA 668355 pitA 4695987 pitA Mycobacterium bovis BCG str. Pasteur 1173P2 low-affinity inorganic phosphate transporter integral membrane protein pitA YP_976686.1 667102 R 410289 CDS YP_976687.1 121636464 4699306 complement(668475..668861) 1 NC_008769.1 hypothetical protein 668861 4699306 BCG_0590c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976687.1 668475 R 410289 CDS YP_976688.1 121636465 4697072 complement(668924..669808) 1 NC_008769.1 short chain dehydrogenase 669808 4697072 BCG_0591c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_976688.1 668924 R 410289 CDS YP_976689.1 121636466 4696042 complement(669904..670848) 1 NC_008769.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 670848 menB 4696042 menB Mycobacterium bovis BCG str. Pasteur 1173P2 naphthoate synthase YP_976689.1 669904 R 410289 CDS YP_976690.1 121636467 4695962 complement(671224..671532) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv0549c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv0549c into 2 parts; hypothetical protein 671532 4695962 BCG_0594c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976690.1 671224 R 410289 CDS YP_976691.1 121636468 4695985 complement(671529..671795) 1 NC_008769.1 hypothetical protein 671795 4695985 BCG_0595c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976691.1 671529 R 410289 CDS YP_976692.1 121636469 4697045 complement(671987..673702) 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 673702 fadD8 4697045 fadD8 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_976692.1 671987 R 410289 CDS YP_976693.1 121636470 4696275 673780..675384 1 NC_008769.1 Differs from Rv0552 and Mb0567 by 1aa, T144I; hypothetical protein 675384 4696275 BCG_0597 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976693.1 673780 D 410289 CDS YP_976694.1 121636471 4696132 675381..676361 1 NC_008769.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 676361 menC 4696132 menC Mycobacterium bovis BCG str. Pasteur 1173P2 O-succinylbenzoate synthase YP_976694.1 675381 D 410289 CDS YP_976695.1 121636472 4696706 676358..677146 1 NC_008769.1 peroxidase bpoC 677146 bpoC 4696706 bpoC Mycobacterium bovis BCG str. Pasteur 1173P2 peroxidase bpoC YP_976695.1 676358 D 410289 CDS YP_976696.1 121636473 4697151 677189..678853 1 NC_008769.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 678853 menD 4697151 menD Mycobacterium bovis BCG str. Pasteur 1173P2 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_976696.1 677189 D 410289 CDS YP_976697.1 121636474 4696707 678850..679365 1 NC_008769.1 Differs from Rv0556 by 1aa, R15L; hypothetical protein 679365 4696707 BCG_0601 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976697.1 678850 D 410289 CDS YP_976698.1 121636475 4696952 679427..680563 1 NC_008769.1 mannosyltransferase 680563 pimB 4696952 pimB Mycobacterium bovis BCG str. Pasteur 1173P2 mannosyltransferase YP_976698.1 679427 D 410289 CDS YP_976699.1 121636476 4697040 680580..681284 1 NC_008769.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 681284 ubiE 4697040 ubiE Mycobacterium bovis BCG str. Pasteur 1173P2 ubiquinone/menaquinone biosynthesis methyltransferase YP_976699.1 680580 D 410289 CDS YP_976700.1 121636477 4696114 complement(681298..681636) 1 NC_008769.1 hypothetical protein 681636 4696114 BCG_0604c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976700.1 681298 R 410289 CDS YP_976701.1 121636478 4696299 complement(681670..682395) 1 NC_008769.1 benzoquinone methyltransferase 682395 4696299 BCG_0605c Mycobacterium bovis BCG str. Pasteur 1173P2 benzoquinone methyltransferase YP_976701.1 681670 R 410289 CDS YP_976702.1 121636479 4696472 complement(682420..683646) 1 NC_008769.1 oxidoreductase 683646 4696472 BCG_0606c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_976702.1 682420 R 410289 CDS YP_976703.1 121636480 4696962 683662..684669 1 NC_008769.1 polyprenyl-diphosphate synthase grcC1 684669 grcC1 4696962 grcC1 Mycobacterium bovis BCG str. Pasteur 1173P2 polyprenyl-diphosphate synthase grcC1 YP_976703.1 683662 D 410289 CDS YP_976704.1 121636481 4697844 684770..685630 1 NC_008769.1 metalloprotease; heat shock protein HtpX 685630 htpX 4697844 htpX Mycobacterium bovis BCG str. Pasteur 1173P2 heat shock protein HtpX YP_976704.1 684770 D 410289 CDS YP_976705.1 121636482 4696304 complement(685815..686840) 1 NC_008769.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 686840 gpdA1 4696304 gpdA1 Mycobacterium bovis BCG str. Pasteur 1173P2 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_976705.1 685815 R 410289 CDS YP_976706.1 121636483 4697624 complement(686901..688361) 1 NC_008769.1 monooxygenase 688361 4697624 BCG_0610c Mycobacterium bovis BCG str. Pasteur 1173P2 monooxygenase YP_976706.1 686901 R 410289 CDS YP_976707.1 121636484 4696458 complement(688439..688930) 1 NC_008769.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 688930 4696458 BCG_0611c Mycobacterium bovis BCG str. Pasteur 1173P2 nucleotide-binding protein YP_976707.1 688439 R 410289 CDS YP_976708.1 121636485 4695654 689212..690231 1 NC_008769.1 Differs from Rv0567 by 1aa, L201F; methyltransferase/methylase 690231 4695654 BCG_0612 Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase/methylase YP_976708.1 689212 D 410289 CDS YP_976709.1 121636486 4695608 690341..691759 1 NC_008769.1 Differs from Rv0568 and Mb0583 by 1aa, E120G; cytochrome p450 135b1 cyp135B1 691759 cyp135B1 4695608 cyp135B1 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome p450 135b1 cyp135B1 YP_976709.1 690341 D 410289 CDS YP_976710.1 121636487 4695493 691894..692160 1 NC_008769.1 hypothetical protein 692160 4695493 BCG_0614 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976710.1 691894 D 410289 CDS YP_976711.1 121636488 4696396 692186..694318 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; ribonucleoside-diphosphate reductase large subunit nrdZ 694318 nrdZ 4696396 nrdZ Mycobacterium bovis BCG str. Pasteur 1173P2 ribonucleoside-diphosphate reductase large subunit nrdZ YP_976711.1 692186 D 410289 CDS YP_976712.1 121636489 4699182 complement(694377..695708) 1 NC_008769.1 Differs from Rv0571c and Mb0586c by 1aa, L258F; hypothetical protein 695708 4699182 BCG_0616c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976712.1 694377 R 410289 CDS YP_976713.1 121636490 4696901 complement(695932..696273) 1 NC_008769.1 Differs from Rv0572c by 1aa, L31F; hypothetical protein 696273 4696901 BCG_0617c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976713.1 695932 R 410289 CDS YP_976714.1 121636491 4696915 complement(696741..698132) 1 NC_008769.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 698132 4696915 BCG_0618c Mycobacterium bovis BCG str. Pasteur 1173P2 nicotinate phosphoribosyltransferase YP_976714.1 696741 R 410289 CDS YP_976715.1 121636492 4696026 complement(698142..699284) 1 NC_008769.1 Differs from Rv0574c by 1aa, K4N; hypothetical protein 699284 4696026 BCG_0619c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976715.1 698142 R 410289 CDS YP_976716.1 121636493 4696312 complement(699500..700636) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base insertion (*-c) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; hypothetical protein 700636 4696312 BCG_0620c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976716.1 699500 R 410289 CDS YP_976717.1 121636494 4695578 700739..702043 1 NC_008769.1 Differs from Rv0576 by 1aa, H233R; ArsR family transcriptional regulator 702043 4695578 BCG_0621 Mycobacterium bovis BCG str. Pasteur 1173P2 ArsR family transcriptional regulator YP_976717.1 700739 D 410289 CDS YP_976718.1 121636495 4696270 702057..702842 1 NC_008769.1 hypothetical protein 702842 TB27.3 4696270 TB27.3 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976718.1 702057 D 410289 CDS YP_976719.1 121636496 4696422 complement(702887..706798) 1 NC_008769.1 Differs from Rv0578c and from Mb0593c by 3aa, there are deleted in Mycobacterium BCG bovis Pasteur; PE-PGRS family protein 706798 PE_PGRS7 4696422 PE_PGRS7 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_976719.1 702887 R 410289 CDS YP_976720.1 121636497 4696989 707120..707878 1 NC_008769.1 hypothetical protein 707878 4696989 BCG_0624 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976720.1 707120 D 410289 CDS YP_976721.1 121636498 4696982 complement(708007..708498) 1 NC_008769.1 hypothetical protein 708498 4696982 BCG_0625c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976721.1 708007 R 410289 CDS YP_976722.1 121636499 4696018 708592..708807 1 NC_008769.1 hypothetical protein 708807 4696018 BCG_0626 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976722.1 708592 D 410289 CDS YP_976723.1 121636500 4695993 708804..709211 1 NC_008769.1 hypothetical protein 709211 4695993 BCG_0627 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976723.1 708804 D 410289 CDS YP_976724.1 121636501 4695963 complement(709271..709957) 1 NC_008769.1 lipoprotein lpqN 709957 lpqN 4695963 lpqN Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqN YP_976724.1 709271 R 410289 CDS YP_976725.1 121636502 4698192 710111..712744 1 NC_008769.1 Differs from Rv0584 by 1aa G90D; hypothetical protein 712744 4698192 BCG_0629 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976725.1 710111 D 410289 CDS YP_976726.1 121636503 4695510 complement(712767..715154) 1 NC_008769.1 Differs from Rv0585c by 1aa V438I and from Mb0600c by 2aa M150I and V438I; integral membrane protein 715154 4695510 BCG_0630c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_976726.1 712767 R 410289 CDS YP_976727.1 121636504 4696936 715292..716014 1 NC_008769.1 GntR family transcriptional regulator 716014 4696936 BCG_0631 Mycobacterium bovis BCG str. Pasteur 1173P2 GntR family transcriptional regulator YP_976727.1 715292 D 410289 CDS YP_976728.1 121636505 4697049 716011..716808 1 NC_008769.1 integral membrane protein YrbE2a 716808 yrbE2A 4697049 yrbE2A Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YrbE2a YP_976728.1 716011 D 410289 CDS YP_976729.1 121636506 4697803 716810..717697 1 NC_008769.1 integral membrane protein YrbE2b 717697 yrbE2B 4697803 yrbE2B Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YrbE2b YP_976729.1 716810 D 410289 CDS YP_976730.1 121636507 4695512 717703..718917 1 NC_008769.1 Differs from Rv0589 by 1aa S51F; mce-family protein mce2A 718917 mce2A 4695512 mce2A Mycobacterium bovis BCG str. Pasteur 1173P2 mce-family protein mce2A YP_976730.1 717703 D 410289 CDS YP_976731.1 121636508 4697200 718914..719945 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, mce2B and Rv0590A are 2 genes, most likely to be linked. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, an in-frame insertion of a single base (*-g) leads to a single product; mce-family protein mce2B 719945 mce2B 4697200 mce2B Mycobacterium bovis BCG str. Pasteur 1173P2 mce-family protein mce2B YP_976731.1 718914 D 410289 CDS YP_976732.1 121636509 4695884 719942..721387 1 NC_008769.1 Differs from Rv0591 by 2aa M49T and N398T; mce-family protein mce2C 721387 mce2C 4695884 mce2C Mycobacterium bovis BCG str. Pasteur 1173P2 mce-family protein mce2C YP_976732.1 719942 D 410289 CDS YP_976733.1 121636510 4695885 721384..722934 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, mce2D exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift occurs in a strech of C (7 for H37Rv, 8 for Mycobactrium bovis and 9 for Mycobacterium bovis BCG). This leads to mceDa genes with different COOH parts and a remnant mc2Db pseudogene; mce-family protein mce2Da 722934 mce2Da 4695885 mce2Da Mycobacterium bovis BCG str. Pasteur 1173P2 mce-family protein mce2Da YP_976733.1 721384 D 410289 CDS YP_976734.1 121636511 4695886 722909..724117 1 NC_008769.1 In Mycobacterium bovis, a single base transition (c-t) introducing a stop codon, leads to the formation of a truncated product compared to its homolog in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur (188 aa versus 402 aa); mce family lipoprotein LprL 724117 lprL 4695886 lprL Mycobacterium bovis BCG str. Pasteur 1173P2 mce family lipoprotein LprL YP_976734.1 722909 D 410289 CDS YP_976735.1 121636512 4698589 724122..725672 1 NC_008769.1 mce-family protein mce2F 725672 mce2F 4698589 mce2F Mycobacterium bovis BCG str. Pasteur 1173P2 mce-family protein mce2F YP_976735.1 724122 D 410289 CDS YP_976736.1 121636513 4695887 complement(725724..726116) 1 NC_008769.1 hypothetical protein 726116 4695887 BCG_0641c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976736.1 725724 R 410289 CDS YP_976737.1 121636514 4696945 complement(726113..726370) 1 NC_008769.1 hypothetical protein 726370 4696945 BCG_0642c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976737.1 726113 R 410289 CDS YP_976738.1 121636515 4695486 complement(726553..727788) 1 NC_008769.1 hypothetical protein 727788 4695486 BCG_0643c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976738.1 726553 R 410289 CDS YP_976739.1 121636516 4696934 complement(728039..728452) 1 NC_008769.1 hypothetical protein 728452 4696934 BCG_0644c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976739.1 728039 R 410289 CDS YP_976740.1 121636517 4696974 complement(728449..728685) 1 NC_008769.1 hypothetical protein 728685 4696974 BCG_0645c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976740.1 728449 R 410289 CDS YP_976741.1 121636518 4696007 complement(728789..729295) 1 NC_008769.1 two component sensor kinase 729295 4696007 BCG_0646c Mycobacterium bovis BCG str. Pasteur 1173P2 two component sensor kinase YP_976741.1 728789 R 410289 CDS YP_976742.1 121636519 4696153 complement(729409..729879) 1 NC_008769.1 two component sensor kinase (first part) 729879 4696153 BCG_0647c Mycobacterium bovis BCG str. Pasteur 1173P2 two component sensor kinase (first part) YP_976742.1 729409 R 410289 CDS YP_976743.1 121636520 4696462 complement(729923..730684) 1 NC_008769.1 Differs from Rv0602c by 1aa I28V; two component DNA binding transcriptional regulatory protein tcrA 730684 tcrA 4696462 tcrA Mycobacterium bovis BCG str. Pasteur 1173P2 two component DNA binding transcriptional regulatory protein tcrA YP_976743.1 729923 R 410289 CDS YP_976744.1 121636521 4696848 730741..731052 1 NC_008769.1 Differs from Mb0619 by 2aa P77A and E96K; hypothetical protein 731052 4696848 BCG_0649 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976744.1 730741 D 410289 CDS YP_976745.1 121636522 4696090 731124..732074 1 NC_008769.1 Differs from Rv0604 by 1aa P180S; lipoprotein lpqO 732074 lpqO 4696090 lpqO Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqO YP_976745.1 731124 D 410289 CDS YP_976746.1 121636523 4698193 732291..732899 1 NC_008769.1 resolvase 732899 4698193 BCG_0651 Mycobacterium bovis BCG str. Pasteur 1173P2 resolvase YP_976746.1 732291 D 410289 CDS YP_976747.1 121636524 4695563 732901..733644 1 NC_008769.1 transposase 733644 4695563 BCG_0652 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_976747.1 732901 D 410289 CDS YP_976748.1 121636525 4696282 733698..734084 1 NC_008769.1 hypothetical protein 734084 4696282 BCG_0653 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976748.1 733698 D 410289 CDS YP_976749.1 121636526 4697062 734129..734374 1 NC_008769.1 hypothetical protein 734374 4697062 BCG_0654 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976749.1 734129 D 410289 CDS YP_976750.1 121636527 4696343 734371..734772 1 NC_008769.1 hypothetical protein 734772 4696343 BCG_0655 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976750.1 734371 D 410289 CDS YP_976751.1 121636528 4695546 734715..734942 1 NC_008769.1 hypothetical protein 734942 4695546 BCG_0656 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976751.1 734715 D 410289 CDS YP_976752.1 121636529 4696366 complement(735637..736794) 1 NC_008769.1 Differs from Rv0610c by 1aa S103N; hypothetical protein 736794 4696366 BCG_0657c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976752.1 735637 R 410289 CDS YP_976753.1 121636530 4696046 complement(736846..737229) 1 NC_008769.1 hypothetical protein 737229 4696046 BCG_0658c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976753.1 736846 R 410289 CDS YP_976754.1 121636531 4696003 737209..737814 1 NC_008769.1 hypothetical protein 737814 4696003 BCG_0659 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976754.1 737209 D 410289 CDS YP_976755.1 121636532 4696290 complement(737833..740400) 1 NC_008769.1 hypothetical protein 740400 4696290 BCG_0660c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976755.1 737833 R 410289 CDS YP_976756.1 121636533 4696919 740241..741233 1 NC_008769.1 hypothetical protein 741233 4696919 BCG_0661 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976756.1 740241 D 410289 CDS YP_976757.1 121636534 4696000 741230..741472 1 NC_008769.1 integral membrane protein 741472 4696000 BCG_0662 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_976757.1 741230 D 410289 CDS YP_976758.1 121636535 4695417 complement(741469..741735) 1 NC_008769.1 hypothetical protein 741735 4695417 BCG_0663c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976758.1 741469 R 410289 CDS YP_976759.1 121636536 4696968 741667..741894 1 NC_008769.1 antitoxin 741894 4696968 BCG_0663A Mycobacterium bovis BCG str. Pasteur 1173P2 antitoxin YP_976759.1 741667 D 410289 CDS YP_976760.1 121636537 4697085 741891..742292 1 NC_008769.1 hypothetical protein 742292 4697085 BCG_0664 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976760.1 741891 D 410289 CDS YP_976761.1 121636538 4696022 742421..743605 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, galT is split into 2 parts, galT' and 'galT. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, an in-frame insertion of a single base (*-a) leads to a single product.Differs from Mb0635 by 1aa R183G and from Rv0619 by 1aa A397T; galactose-1-phosphate uridylyltransferase galT 743605 galT 4696022 galT Mycobacterium bovis BCG str. Pasteur 1173P2 galactose-1-phosphate uridylyltransferase galT YP_976761.1 742421 D 410289 CDS YP_976762.1 121636539 4695534 743602..744693 1 NC_008769.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 744693 galK 4695534 galK Mycobacterium bovis BCG str. Pasteur 1173P2 galactokinase YP_976762.1 743602 D 410289 CDS YP_976763.1 121636540 4695533 745088..746245 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a single base transition (a-g) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (385 aa versus 354 aa); hypothetical protein 746245 4695533 BCG_0667 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976763.1 745088 D 410289 CDS YP_976764.1 121636541 4696976 746256..747203 1 NC_008769.1 hypothetical protein 747203 4696976 BCG_0668 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976764.1 746256 D 410289 CDS YP_976765.1 121636542 4696463 747296..747550 1 NC_008769.1 hypothetical protein 747550 4696463 BCG_0669 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976765.1 747296 D 410289 CDS YP_976766.1 121636543 4696931 747550..747945 1 NC_008769.1 hypothetical protein 747945 4696931 BCG_0670 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976766.1 747550 D 410289 CDS YP_976767.1 121636544 4696911 complement(748039..748779) 1 NC_008769.1 hypothetical protein 748779 4696911 BCG_0671c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976767.1 748039 R 410289 CDS YP_976768.1 121636545 4697142 748911..749171 1 NC_008769.1 hypothetical protein 749171 4697142 BCG_0672 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976768.1 748911 D 410289 CDS YP_976769.1 121636546 4696928 749168..749575 1 NC_008769.1 hypothetical protein 749575 4696928 BCG_0673 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976769.1 749168 D 410289 CDS YP_976770.1 121636547 4697437 complement(749647..750798) 1 NC_008769.1 hypothetical protein 750798 4697437 BCG_0674c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976770.1 749647 R 410289 CDS YP_976771.1 121636548 4697372 complement(750891..752618) 1 NC_008769.1 Differs from Rv0629c by 1aa A536T; exonuclease V (alpha chain) recD 752618 recD 4697372 recD Mycobacterium bovis BCG str. Pasteur 1173P2 exonuclease V (alpha chain) recD YP_976771.1 750891 R 410289 CDS YP_976772.1 121636549 4696079 complement(753205..755898) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, recB exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (g-*) splits recB into 2 parts, recBa and recBb. Differs from Mb0647c by 1aa H514R and from Rv0630c by 3aa L74V, H514R and F811V; exonuclease V subunit beta recBa 755898 recBa 4696079 recBa Mycobacterium bovis BCG str. Pasteur 1173P2 exonuclease V subunit beta recBa YP_976772.1 753205 R 410289 CDS YP_976773.1 121636550 4697310 complement(755898..759191) 1 NC_008769.1 Differs from Rv0631c by 1aa E329G and from Mb0648c by 1aa P858L; exonuclease V (gamma chain) recC 759191 recC 4697310 recC Mycobacterium bovis BCG str. Pasteur 1173P2 exonuclease V (gamma chain) recC YP_976773.1 755898 R 410289 CDS YP_976774.1 121636551 4696080 complement(759468..760163) 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 760163 echA3 4696080 echA3 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_976774.1 759468 R 410289 CDS YP_976775.1 121636552 4699210 complement(760212..761042) 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 9 bp deletion (cgggtgcgc-*) leads to shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (276 aa versus 279 aa); hypothetical protein 761042 4699210 BCG_0680c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976775.1 760212 R 410289 CDS YP_976776.1 121636553 4697168 complement(761196..761909) 1 NC_008769.1 glyoxalase II 761909 4697168 BCG_0681c Mycobacterium bovis BCG str. Pasteur 1173P2 glyoxalase II YP_976776.1 761196 R 410289 CDS YP_976777.1 121636554 4697369 761989..762240 1 NC_008769.1 hypothetical protein 762240 4697369 BCG_0682 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976777.1 761989 D 410289 CDS YP_976778.1 121636555 4697284 762588..762755 1 NC_008769.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 762755 rpmG 4697284 rpmG Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L33 YP_976778.1 762588 D 410289 CDS YP_976779.1 121636556 4695798 762806..763282 1 NC_008769.1 functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadA 763282 4695798 BCG_0684 Mycobacterium bovis BCG str. Pasteur 1173P2 (3R)-hydroxyacyl-ACP dehydratase subunit HadA YP_976779.1 762806 D 410289 CDS YP_976780.1 121636557 4697374 763269..763697 1 NC_008769.1 functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadB 763697 4697374 BCG_0685 Mycobacterium bovis BCG str. Pasteur 1173P2 (3R)-hydroxyacyl-ACP dehydratase subunit HadB YP_976780.1 763269 D 410289 CDS YP_976781.1 121636558 4697376 763701..764201 1 NC_008769.1 functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadC 764201 4697376 BCG_0686 Mycobacterium bovis BCG str. Pasteur 1173P2 (3R)-hydroxyacyl-ACP dehydratase subunit HadC YP_976781.1 763701 D 410289 CDS YP_976782.1 121636559 4695653 764613..765098 1 NC_008769.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 765098 secE 4695653 secE Mycobacterium bovis BCG str. Pasteur 1173P2 preprotein translocase subunit SecE YP_976782.1 764613 D 410289 CDS YP_976783.1 121636560 4697707 765130..765846 1 NC_008769.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 765846 nusG 4697707 nusG Mycobacterium bovis BCG str. Pasteur 1173P2 transcription antitermination protein NusG YP_976783.1 765130 D 410289 CDS YP_976784.1 121636561 4696323 765898..766326 1 NC_008769.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 766326 rplK 4696323 rplK Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L11 YP_976784.1 765898 D 410289 CDS YP_976785.1 121636562 4695926 766393..767100 1 NC_008769.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 767100 rplA 4695926 rplA Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L1 YP_976785.1 766393 D 410289 CDS YP_976786.1 121636563 4699114 complement(767174..768079) 1 NC_008769.1 Differs from Rv0642c by 1aa L95F; methoxy mycolic acid synthase 768079 mmaA4 4699114 mmaA4 Mycobacterium bovis BCG str. Pasteur 1173P2 methoxy mycolic acid synthase YP_976786.1 767174 R 410289 CDS YP_976787.1 121636564 4697159 complement(768144..769025) 1 NC_008769.1 methoxy mycolic acid synthase 769025 mmaA3 4697159 mmaA3 Mycobacterium bovis BCG str. Pasteur 1173P2 methoxy mycolic acid synthase YP_976787.1 768144 R 410289 CDS YP_976788.1 121636565 4697158 complement(769173..770036) 1 NC_008769.1 differs from Rv0644c by 1aa L114R; methoxy mycolic acid synthase 770036 mmaA2 4697158 mmaA2 Mycobacterium bovis BCG str. Pasteur 1173P2 methoxy mycolic acid synthase YP_976788.1 769173 R 410289 CDS YP_976789.1 121636566 4697157 complement(770203..771063) 1 NC_008769.1 methoxy mycolic acid synthase 771063 mmaA1 4697157 mmaA1 Mycobacterium bovis BCG str. Pasteur 1173P2 methoxy mycolic acid synthase YP_976789.1 770203 R 410289 CDS YP_976790.1 121636567 4697156 complement(771110..772015) 1 NC_008769.1 lipase/esterase lipG 772015 lipG 4697156 lipG Mycobacterium bovis BCG str. Pasteur 1173P2 lipase/esterase lipG YP_976790.1 771110 R 410289 CDS YP_976791.1 121636568 4698086 complement(772027..773493) 1 NC_008769.1 Differs from Rv0647c by 1aa T293A; hypothetical protein 773493 4698086 BCG_0696c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976791.1 772027 R 410289 CDS YP_976792.1 121636569 4697362 773579..777775 1 NC_008769.1 Differs from Rv0648 by 1aa L200S; alpha-mannosidase 777775 4697362 BCG_0697 Mycobacterium bovis BCG str. Pasteur 1173P2 alpha-mannosidase YP_976792.1 773579 D 410289 CDS YP_976793.1 121636570 4697502 777772..778446 1 NC_008769.1 malonyl CoA-ACP transacylase 778446 fabD2 4697502 fabD2 Mycobacterium bovis BCG str. Pasteur 1173P2 malonyl CoA-ACP transacylase YP_976793.1 777772 D 410289 CDS YP_976794.1 121636571 4698482 778446..779354 1 NC_008769.1 sugar kinase 779354 4698482 BCG_0699 Mycobacterium bovis BCG str. Pasteur 1173P2 sugar kinase YP_976794.1 778446 D 410289 CDS YP_976795.1 121636572 4697518 779685..780221 1 NC_008769.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 780221 rplJ 4697518 rplJ Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L10 YP_976795.1 779685 D 410289 CDS YP_976796.1 121636573 4695925 780258..780650 1 NC_008769.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 780650 rplL 4695925 rplL Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L7/L12 YP_976796.1 780258 D 410289 CDS YP_976797.1 121636574 4695927 complement(780643..781338) 1 NC_008769.1 TetR family transcriptional regulator 781338 4695927 BCG_0702c Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_976797.1 780643 R 410289 CDS YP_976798.1 121636575 4697453 781409..782914 1 NC_008769.1 dioxygenase 782914 4697453 BCG_0703 Mycobacterium bovis BCG str. Pasteur 1173P2 dioxygenase YP_976798.1 781409 D 410289 CDS YP_976799.1 121636576 4697537 782926..784005 1 NC_008769.1 ribonucleotide-transport ATP-binding protein ABC transporter mkl 784005 mkl 4697537 mkl Mycobacterium bovis BCG str. Pasteur 1173P2 ribonucleotide-transport ATP-binding protein ABC transporter mkl YP_976799.1 782926 D 410289 CDS YP_976800.1 121636577 4697155 complement(784393..784776) 1 NC_008769.1 hypothetical protein 784776 4697155 BCG_0705c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976800.1 784393 R 410289 CDS YP_976801.1 121636578 4697506 complement(784871..785026) 1 NC_008769.1 hypothetical protein 785026 4697506 BCG_0706c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976801.1 784871 R 410289 CDS YP_976802.1 121636579 4697499 complement(785102..785818) 1 NC_008769.1 Differs from Rv0658c by 1aa P75L; integral membrane protein 785818 4697499 BCG_0707c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_976802.1 785102 R 410289 CDS YP_976803.1 121636580 4697661 complement(786094..786402) 1 NC_008769.1 hypothetical protein 786402 4697661 BCG_0708c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976803.1 786094 R 410289 CDS YP_976804.1 121636581 4698808 complement(786389..786634) 1 NC_008769.1 hypothetical protein 786634 4698808 BCG_0709c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976804.1 786389 R 410289 CDS YP_976805.1 121636582 4697573 complement(786744..787181) 1 NC_008769.1 hypothetical protein 787181 4697573 BCG_0710c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976805.1 786744 R 410289 CDS YP_976806.1 121636583 4697866 complement(787178..787546) 1 NC_008769.1 hypothetical protein 787546 4697866 BCG_0711c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976806.1 787178 R 410289 CDS YP_976807.1 121636584 4697741 787546..789909 1 NC_008769.1 Differs from Rv0663 by 1aa G349D; arylsulfatase atsD 789909 atsD 4697741 atsD Mycobacterium bovis BCG str. Pasteur 1173P2 arylsulfatase atsD YP_976807.1 787546 D 410289 CDS YP_976808.1 121636585 4696184 789941..790213 1 NC_008769.1 hypothetical protein 790213 4696184 BCG_0713 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976808.1 789941 D 410289 CDS YP_976809.1 121636586 4697901 790210..790548 1 NC_008769.1 hypothetical protein 790548 4697901 BCG_0714 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976809.1 790210 D 410289 CDS YP_976810.1 121636587 4697718 790545..790718 1 NC_008769.1 hypothetical protein 790718 4697718 BCG_0715 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976810.1 790545 D 410289 CDS YP_976811.1 121636588 4697686 791216..794734 1 NC_008769.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 794734 rpoB 4697686 rpoB Mycobacterium bovis BCG str. Pasteur 1173P2 DNA-directed RNA polymerase subunit beta YP_976811.1 791216 D 410289 CDS YP_976812.1 121636589 4696375 794779..798729 1 NC_008769.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 798729 rpoC 4696375 rpoC Mycobacterium bovis BCG str. Pasteur 1173P2 DNA-directed RNA polymerase subunit beta' YP_976812.1 794779 D 410289 CDS YP_976813.1 121636590 4696376 complement(799093..801006) 1 NC_008769.1 Differs from Rv0669c by 1aa P146S; hydrolase 801006 4696376 BCG_0718c Mycobacterium bovis BCG str. Pasteur 1173P2 hydrolase YP_976813.1 799093 R 410289 CDS YP_976814.1 121636591 4697867 801201..801959 1 NC_008769.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 801959 end 4697867 end Mycobacterium bovis BCG str. Pasteur 1173P2 endonuclease IV YP_976814.1 801201 D 410289 CDS YP_976815.1 121636592 4697930 801991..802833 1 NC_008769.1 lipoprotein lpqP 802833 lpqP 4697930 lpqP Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqP YP_976815.1 801991 D 410289 CDS YP_976816.1 121636593 4698194 802893..804521 1 NC_008769.1 acyl-CoA dehydrogenase fadE8 804521 fadE8 4698194 fadE8 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE8 YP_976816.1 802893 D 410289 CDS YP_976817.1 121636594 4696259 804532..805470 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 805470 echA4 4696259 echA4 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_976817.1 804532 D 410289 CDS YP_976818.1 121636595 4696014 805473..806195 1 NC_008769.1 hypothetical protein 806195 4696014 BCG_0723 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976818.1 805473 D 410289 CDS YP_976819.1 121636596 4697642 806192..806983 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 806983 echA5 4697642 echA5 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_976819.1 806192 D 410289 CDS YP_976820.1 121636597 4699064 complement(806995..809889) 1 NC_008769.1 Differs from Rv0676c by 2aa I793T and V948I; transmembrane transport protein mmpL5 809889 mmpL5 4699064 mmpL5 Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane transport protein mmpL5 YP_976820.1 806995 R 410289 CDS YP_976821.1 121636598 4696171 complement(809886..810314) 1 NC_008769.1 membrane protein mmpS5 810314 mmpS5 4696171 mmpS5 Mycobacterium bovis BCG str. Pasteur 1173P2 membrane protein mmpS5 YP_976821.1 809886 R 410289 CDS YP_976822.1 121636599 4697597 810399..810896 1 NC_008769.1 hypothetical protein 810896 4697597 BCG_0727 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976822.1 810399 D 410289 CDS YP_976823.1 121636600 4697592 complement(810952..811449) 1 NC_008769.1 hypothetical protein 811449 4697592 BCG_0728c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976823.1 810952 R 410289 CDS YP_976824.1 121636601 4697660 complement(811451..811825) 1 NC_008769.1 hypothetical protein 811825 4697660 BCG_0729c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976824.1 811451 R 410289 CDS YP_976825.1 121636602 4697510 812130..812720 1 NC_008769.1 TetR family transcriptional regulator 812720 4697510 BCG_0730 Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_976825.1 812130 D 410289 CDS YP_976826.1 121636603 4697532 812969..813343 1 NC_008769.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 813343 rpsL 4697532 rpsL Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S12 YP_976826.1 812969 D 410289 CDS YP_976827.1 121636604 4698849 813343..813813 1 NC_008769.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 813813 rpsG 4698849 rpsG Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S7 YP_976827.1 813343 D 410289 CDS YP_976828.1 121636605 4695754 813894..815999 1 NC_008769.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 815999 fusA1 4695754 fusA1 Mycobacterium bovis BCG str. Pasteur 1173P2 elongation factor G YP_976828.1 813894 D 410289 CDS YP_976829.1 121636606 4695506 816230..817420 1 NC_008769.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 817420 tuf 4695506 tuf Mycobacterium bovis BCG str. Pasteur 1173P2 elongation factor Tu YP_976829.1 816230 D 410289 CDS YP_976830.1 121636607 4697091 817558..818355 1 NC_008769.1 Differs from Rv0686 by 1aa S82I; hypothetical protein 818355 4697091 BCG_0735 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976830.1 817558 D 410289 CDS YP_976831.1 121636608 4697582 818508..819335 1 NC_008769.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 819335 fabG 4697582 fabG Mycobacterium bovis BCG str. Pasteur 1173P2 3-ketoacyl-ACP reductase YP_976831.1 818508 D 410289 CDS YP_976832.1 121636609 4697782 819349..820569 1 NC_008769.1 ferredoxin reductase 820569 4697782 BCG_0737 Mycobacterium bovis BCG str. Pasteur 1173P2 ferredoxin reductase YP_976832.1 819349 D 410289 CDS YP_976833.1 121636610 4697242 complement(820566..820820) 1 NC_008769.1 hypothetical protein 820820 4697242 BCG_0738c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976833.1 820566 R 410289 CDS YP_976834.1 121636611 4697439 complement(821433..822482) 1 NC_008769.1 hypothetical protein 822482 4697439 BCG_0739c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976834.1 821433 R 410289 CDS YP_976835.1 121636612 4697209 complement(822479..823075) 1 NC_008769.1 transcriptional regulatory protein 823075 4697209 BCG_0740c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976835.1 822479 R 410289 CDS YP_976836.1 121636613 4697163 823240..823569 1 NC_008769.1 hypothetical protein 823569 4697163 BCG_0741 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976836.1 823240 D 410289 CDS YP_976837.1 121636614 4697233 823566..824741 1 NC_008769.1 coenzyme PQQ synthesis protein E pqqE 824741 pqqE 4697233 pqqE Mycobacterium bovis BCG str. Pasteur 1173P2 coenzyme PQQ synthesis protein E pqqE YP_976837.1 823566 D 410289 CDS YP_976838.1 121636615 4696489 824744..825934 1 NC_008769.1 L-lactate dehydrogenase (cytochrome) lldD1 825934 lldD1 4696489 lldD1 Mycobacterium bovis BCG str. Pasteur 1173P2 L-lactate dehydrogenase (cytochrome) lldD1 YP_976838.1 824744 D 410289 CDS YP_976839.1 121636616 4695785 826124..826879 1 NC_008769.1 hypothetical protein 826879 4695785 BCG_0744 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976839.1 826124 D 410289 CDS YP_976840.1 121636617 4697153 826928..828340 1 NC_008769.1 membrane sugar transferase 828340 4697153 BCG_0745 Mycobacterium bovis BCG str. Pasteur 1173P2 membrane sugar transferase YP_976840.1 826928 D 410289 CDS YP_976841.1 121636618 4697170 828342..829781 1 NC_008769.1 dehydrogenase 829781 4697170 BCG_0746 Mycobacterium bovis BCG str. Pasteur 1173P2 dehydrogenase YP_976841.1 828342 D 410289 CDS YP_976842.1 121636619 4697137 830242..830571 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718; hypothetical protein 830571 4697137 BCG_0747 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976842.1 830242 D 410289 CDS YP_976843.1 121636620 4697106 830619..830852 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718; hypothetical protein 830852 4697106 BCG_0748 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976843.1 830619 D 410289 CDS YP_976844.1 121636621 4697055 831037..831258 1 NC_008769.1 hypothetical protein 831258 4697055 BCG_0749 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976844.1 831037 D 410289 CDS YP_976845.1 121636622 4697101 831895..832200 1 NC_008769.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 832200 rpsJ 4697101 rpsJ Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S10 YP_976845.1 831895 D 410289 CDS YP_976846.1 121636623 4695757 832217..832870 1 NC_008769.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 832870 rplC 4695757 rplC Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L3 YP_976846.1 832217 D 410289 CDS YP_976847.1 121636624 4695852 832870..833541 1 NC_008769.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 833541 rplD 4695852 rplD Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L4 YP_976847.1 832870 D 410289 CDS YP_976848.1 121636625 4695853 833541..833843 1 NC_008769.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 833843 rplW 4695853 rplW Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L23 YP_976848.1 833541 D 410289 CDS YP_976849.1 121636626 4695883 833990..834832 1 NC_008769.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 834832 rplB 4695883 rplB Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L2 YP_976849.1 833990 D 410289 CDS YP_976850.1 121636627 4695851 834873..835154 1 NC_008769.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 835154 rpsS 4695851 rpsS Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S19 YP_976850.1 834873 D 410289 CDS YP_976851.1 121636628 4695809 835151..835744 1 NC_008769.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 835744 rplV 4695809 rplV Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L22 YP_976851.1 835151 D 410289 CDS YP_976852.1 121636629 4695882 835744..836568 1 NC_008769.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 836568 rpsC 4695882 rpsC Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S3 YP_976852.1 835744 D 410289 CDS YP_976853.1 121636630 4697297 836572..836988 1 NC_008769.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 836988 rplP 4697297 rplP Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L16 YP_976853.1 836572 D 410289 CDS YP_976854.1 121636631 4695891 836988..837221 1 NC_008769.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 837221 rpmC 4695891 rpmC Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L29 YP_976854.1 836988 D 410289 CDS YP_976855.1 121636632 4696783 837218..837628 1 NC_008769.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 837628 rpsQ 4696783 rpsQ Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S17 YP_976855.1 837218 D 410289 CDS YP_976856.1 121636633 4695806 837797..840160 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur, atsA exists as a single gene. In Mycobacterium bovis, a single base transversion (g-t), introducing a stop codon, splits atsA into 2 parts, atsAa and atsAb; arylsulfatase atsA 840160 atsA 4695806 atsA Mycobacterium bovis BCG str. Pasteur 1173P2 arylsulfatase atsA YP_976856.1 837797 D 410289 CDS YP_976857.1 121636634 4696242 840208..841107 1 NC_008769.1 hypothetical protein 841107 4696242 BCG_0762 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976857.1 840208 D 410289 CDS YP_976858.1 121636635 4697057 841408..842349 1 NC_008769.1 hypothetical protein 842349 4697057 BCG_0763 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976858.1 841408 D 410289 CDS YP_976859.1 121636636 4696977 842836..843204 1 NC_008769.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 843204 rplN 4696977 rplN Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L14 YP_976859.1 842836 D 410289 CDS YP_976860.1 121636637 4695889 843205..843522 1 NC_008769.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 843522 rplX 4695889 rplX Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L24 YP_976860.1 843205 D 410289 CDS YP_976861.1 121636638 4697626 843522..844085 1 NC_008769.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 844085 rplE 4697626 rplE Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L5 YP_976861.1 843522 D 410289 CDS YP_976862.1 121636639 4695854 844090..844275 1 NC_008769.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 844275 rpsN 4695854 rpsN Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S14 YP_976862.1 844090 D 410289 CDS YP_976863.1 121636640 4698851 844439..844837 1 NC_008769.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 844837 rpsH 4698851 rpsH Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S8 YP_976863.1 844439 D 410289 CDS YP_976864.1 121636641 4695755 844861..845400 1 NC_008769.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 845400 rplF 4695755 rplF Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L6 YP_976864.1 844861 D 410289 CDS YP_976865.1 121636642 4695855 845403..845771 1 NC_008769.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 845771 rplR 4695855 rplR Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L18 YP_976865.1 845403 D 410289 CDS YP_976866.1 121636643 4695893 845791..846453 1 NC_008769.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 846453 rpsE 4695893 rpsE Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S5 YP_976866.1 845791 D 410289 CDS YP_976867.1 121636644 4697299 846456..846653 1 NC_008769.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 846653 rpmD 4697299 rpmD Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L30 YP_976867.1 846456 D 410289 CDS YP_976868.1 121636645 4696784 846653..847093 1 NC_008769.1 late assembly protein; 50S ribosomal protein L15 847093 rplO 4696784 rplO Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L15 YP_976868.1 846653 D 410289 CDS YP_976869.1 121636646 4695890 847126..848997 1 NC_008769.1 protease IV sppA (endopeptidase IV) 848997 sppA 4695890 sppA Mycobacterium bovis BCG str. Pasteur 1173P2 protease IV sppA (endopeptidase IV) YP_976869.1 847126 D 410289 CDS YP_976870.1 121636647 4695624 complement(849002..849907) 1 NC_008769.1 hypothetical protein 849907 4695624 BCG_0775c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976870.1 849002 R 410289 CDS YP_976871.1 121636648 4696874 complement(850000..851103) 1 NC_008769.1 hypothetical protein 851103 4696874 BCG_0776c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976871.1 850000 R 410289 CDS YP_976872.1 121636649 4696764 complement(851306..851962) 1 NC_008769.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 851962 fucA 4696764 fucA Mycobacterium bovis BCG str. Pasteur 1173P2 L-fuculose phosphate aldolase YP_976872.1 851306 R 410289 CDS YP_976873.1 121636650 4698536 complement(851959..852939) 1 NC_008769.1 Differs from Rv0728c by 1aa H242R; D-3-phosphoglycerate dehydrogenase serA2 852939 serA2 4698536 serA2 Mycobacterium bovis BCG str. Pasteur 1173P2 D-3-phosphoglycerate dehydrogenase serA2 YP_976873.1 851959 R 410289 CDS YP_976874.1 121636651 4697884 852970..854316 1 NC_008769.1 Differs from Rv0729 by 2aa P134L and S439; d-xylulose kinase xylB 854316 xylB 4697884 xylB Mycobacterium bovis BCG str. Pasteur 1173P2 d-xylulose kinase xylB YP_976874.1 852970 D 410289 CDS YP_976875.1 121636652 4697558 854329..855057 1 NC_008769.1 hypothetical protein 855057 4697558 BCG_0780 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976875.1 854329 D 410289 CDS YP_976876.1 121636653 4696695 complement(855146..856102) 1 NC_008769.1 hypothetical protein 856102 4696695 BCG_0781c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976876.1 855146 R 410289 CDS YP_976877.1 121636654 4696747 856263..857588 1 NC_008769.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 857588 secY 4696747 secY Mycobacterium bovis BCG str. Pasteur 1173P2 preprotein translocase subunit SecY YP_976877.1 856263 D 410289 CDS YP_976878.1 121636655 4697881 857585..858130 1 NC_008769.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 858130 adk 4697881 adk Mycobacterium bovis BCG str. Pasteur 1173P2 adenylate kinase YP_976878.1 857585 D 410289 CDS YP_976879.1 121636656 4697641 858133..858933 1 NC_008769.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 858933 mapA 4697641 mapA Mycobacterium bovis BCG str. Pasteur 1173P2 methionine aminopeptidase YP_976879.1 858133 D 410289 CDS YP_976880.1 121636657 4698661 859006..859539 1 NC_008769.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein regulates polyketide synthases and secreted or membrane proteins; RNA polymerase sigma factor SigL 859539 sigL 4698661 sigL Mycobacterium bovis BCG str. Pasteur 1173P2 RNA polymerase sigma factor SigL YP_976880.1 859006 D 410289 CDS YP_976881.1 121636658 4696444 859603..860355 1 NC_008769.1 hypothetical protein 860355 4696444 BCG_0786 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976881.1 859603 D 410289 CDS YP_976882.1 121636659 4696686 860670..861167 1 NC_008769.1 transcriptional regulatory protein 861167 4696686 BCG_0787 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976882.1 860670 D 410289 CDS YP_976883.1 121636660 4696739 861525..862073 1 NC_008769.1 hypothetical protein 862073 4696739 BCG_0788 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976883.1 861525 D 410289 CDS YP_976884.1 121636661 4696722 862278..863126 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 2 bp insertion (*-cg) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (282 aa versus 268 aa); hypothetical protein 863126 4696722 BCG_0789 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976884.1 862278 D 410289 CDS YP_976885.1 121636662 4696593 863241..863768 1 NC_008769.1 hypothetical protein 863768 4696593 BCG_0790 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976885.1 863241 D 410289 CDS YP_976886.1 121636663 4696620 863999..864313 1 NC_008769.1 transposase 864313 4696620 BCG_0791 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_976886.1 863999 D 410289 CDS YP_976887.1 121636664 4696650 864455..864973 1 NC_008769.1 PE-PGRS family protein 864973 PE_PGRS8 4696650 PE_PGRS8 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_976887.1 864455 D 410289 CDS YP_976888.1 121636665 4696990 complement(865351..865908) 1 NC_008769.1 hypothetical protein 865908 4696990 BCG_0793c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976888.1 865351 R 410289 CDS YP_976889.1 121636666 4696559 complement(865905..866411) 1 NC_008769.1 transcriptional regulatory protein 866411 4696559 BCG_0794c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976889.1 865905 R 410289 CDS YP_976890.1 121636667 4696566 866619..867146 1 NC_008769.1 hypothetical protein 867146 4696566 BCG_0795 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976890.1 866619 D 410289 CDS YP_976891.1 121636668 4696604 867166..869559 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, two 48 bp deletions, and a 138 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (797 aa versus 783 aa). Differs from Mb0767 by 1aa S597N; PE-PGRS family protein 869559 PE_PGRS9 4696604 PE_PGRS9 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_976891.1 867166 D 410289 CDS YP_976892.1 121636669 4696991 869958..872639 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, insertions of 168 bp and 105 bp, a 11 bp for 71 bp substitution, and a 9 bp deletion (cggcaacgg-*), leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (909 aa and 893 aa versus 801 aa). In addition, in Mycobacterium bovis BCG Pasteur, a 48 bp deletion compared to Mycobacterium bovis and Mycobacterium tuberculosis strain H37Rv occurs; PE-PGRS family protein 872639 PE_PGRS10 4696991 PE_PGRS10 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_976892.1 869958 D 410289 CDS YP_976893.1 121636670 4696297 872730..872987 1 NC_008769.1 hypothetical protein 872987 4696297 BCG_0798 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976893.1 872730 D 410289 CDS YP_976894.1 121636671 4696806 873011..873439 1 NC_008769.1 hypothetical protein 873439 4696806 BCG_0799 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976894.1 873011 D 410289 CDS YP_976895.1 121636672 4696430 complement(873520..873657) 1 NC_008769.1 hypothetical protein 873657 4696430 BCG_0800c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976895.1 873520 R 410289 CDS YP_976896.1 121636673 4696385 873816..874061 1 NC_008769.1 hypothetical protein 874061 4696385 BCG_0801 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976896.1 873816 D 410289 CDS YP_976897.1 121636674 4696283 complement(874130..875014) 1 NC_008769.1 3-hydroxyisobutyrate dehydrogenase 875014 mmsB 4696283 mmsB Mycobacterium bovis BCG str. Pasteur 1173P2 3-hydroxyisobutyrate dehydrogenase YP_976897.1 874130 R 410289 CDS YP_976898.1 121636675 4697601 complement(875025..876197) 1 NC_008769.1 Differs from Rv0752c by 2aa A69V and V186I; acyl-CoA dehydrogenase fadE9 876197 fadE9 4697601 fadE9 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE9 YP_976898.1 875025 R 410289 CDS YP_976899.1 121636676 4695680 complement(876204..877736) 1 NC_008769.1 Differs from Mb0775c by 1aa V442G; methylmalonate-semialdehyde dehydrogenase mmsA 877736 mmsA 4695680 mmsA Mycobacterium bovis BCG str. Pasteur 1173P2 methylmalonate-semialdehyde dehydrogenase mmsA YP_976899.1 876204 R 410289 CDS YP_976900.1 121636677 4697600 877942..879696 1 NC_008769.1 PE-PGRS family protein 879696 PE_PGRS11 4697600 PE_PGRS11 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_976900.1 877942 D 410289 CDS YP_976901.1 121636678 4697794 complement(879886..881823) 1 NC_008769.1 Differs from Rv0755c by 1aa K545R; PPE family protein 881823 PPE12 4697794 PPE12 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_976901.1 879886 R 410289 CDS YP_976902.1 121636679 4696163 complement(882125..882310) 1 NC_008769.1 transposase 882310 4696163 BCG_0807c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_976902.1 882125 R 410289 CDS YP_976903.1 121636680 4695652 complement(882524..883249) 1 NC_008769.1 hypothetical protein 883249 4695652 BCG_0808c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976903.1 882524 R 410289 CDS YP_976904.1 121636681 4696141 883391..884134 1 NC_008769.1 two component system response transcriptional positive regulator phoP 884134 phoP 4696141 phoP Mycobacterium bovis BCG str. Pasteur 1173P2 two component system response transcriptional positive regulator phoP YP_976904.1 883391 D 410289 CDS YP_976905.1 121636682 4697587 884179..885636 1 NC_008769.1 Differs from Rv0755c by 2aa I71G, L172P; two component system response sensor kinase membrane associated phoR 885636 phoR 4697587 phoR Mycobacterium bovis BCG str. Pasteur 1173P2 two component system response sensor kinase membrane associated phoR YP_976905.1 884179 D 410289 CDS YP_976906.1 121636683 4698178 complement(885608..885940) 1 NC_008769.1 hypothetical protein 885940 4698178 BCG_0811c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976906.1 885608 R 410289 CDS YP_976907.1 121636684 4696971 complement(886049..886468) 1 NC_008769.1 hypothetical protein 886468 4696971 BCG_0812c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976907.1 886049 R 410289 CDS YP_976908.1 121636685 4697429 complement(886481..887608) 1 NC_008769.1 zinc-containing alcohol dehydrogenaseAdhB 887608 adhB 4697429 adhB Mycobacterium bovis BCG str. Pasteur 1173P2 zinc-containing alcohol dehydrogenaseAdhB YP_976908.1 886481 R 410289 CDS YP_976909.1 121636686 4697504 complement(887707..888252) 1 NC_008769.1 hypothetical protein 888252 4697504 BCG_0814c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976909.1 887707 R 410289 CDS YP_976910.1 121636687 4697751 complement(888255..888461) 1 NC_008769.1 ferredoxin 888461 4697751 BCG_0815c Mycobacterium bovis BCG str. Pasteur 1173P2 ferredoxin YP_976910.1 888255 R 410289 CDS YP_976911.1 121636688 4696762 complement(888464..889819) 1 NC_008769.1 cytochrome P450 51 cyp51 889819 cyp51 4696762 cyp51 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome P450 51 cyp51 YP_976911.1 888464 R 410289 CDS YP_976912.1 121636689 4696288 complement(889819..890646) 1 NC_008769.1 short chain dehydrogenase 890646 4696288 BCG_0817c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_976912.1 889819 R 410289 CDS YP_976913.1 121636690 4696040 complement(890228..891853) 1 NC_008769.1 cytochrome P450 123 cyp123 891853 cyp123 4696040 cyp123 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome P450 123 cyp123 YP_976913.1 890228 R 410289 CDS YP_976914.1 121636691 4696899 complement(891850..892491) 1 NC_008769.1 hypothetical protein 892491 4696899 BCG_0819c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976914.1 891850 R 410289 CDS YP_976915.1 121636692 4695983 892693..894162 1 NC_008769.1 aldehyde dehydrogenase AldA 894162 aldA 4695983 aldA Mycobacterium bovis BCG str. Pasteur 1173P2 aldehyde dehydrogenase AldA YP_976915.1 892693 D 410289 CDS YP_976916.1 121636693 4698993 894193..894939 1 NC_008769.1 Differs from Rv0769 by 1aa V55A; short chain dehydrogenase 894939 4698993 BCG_0821 Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_976916.1 894193 D 410289 CDS YP_976917.1 121636694 4697056 895037..895924 1 NC_008769.1 Differs from Mb0793 by 1aa V126G; dehydrogenase/reductase 895924 4697056 BCG_0822 Mycobacterium bovis BCG str. Pasteur 1173P2 dehydrogenase/reductase YP_976917.1 895037 D 410289 CDS YP_976918.1 121636695 4696023 895921..896355 1 NC_008769.1 4-carboxymuconolactone decarboxylase 896355 4696023 BCG_0823 Mycobacterium bovis BCG str. Pasteur 1173P2 4-carboxymuconolactone decarboxylase YP_976918.1 895921 D 410289 CDS YP_976919.1 121636696 4697643 896367..897635 1 NC_008769.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 897635 purD 4697643 purD Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoribosylamine--glycine ligase YP_976919.1 896367 D 410289 CDS YP_976920.1 121636697 4699228 complement(897632..899170) 1 NC_008769.1 bifunctional acylase ggtA: cephalosporin acylase + gamma-glutamyltranspeptidase 899170 ggtA 4699228 ggtA Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional acylase ggtA: cephalosporin acylase + gamma-glutamyltranspeptidase YP_976920.1 897632 R 410289 CDS YP_976921.1 121636698 4698647 complement(899221..900132) 1 NC_008769.1 Differs from Rv0774c by 1aa A219S and from Mb0797c by 1aa D142A; hypothetical protein 900132 4698647 BCG_0826c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976921.1 899221 R 410289 CDS YP_976922.1 121636699 4696235 900188..900811 1 NC_008769.1 hypothetical protein 900811 4696235 BCG_0827 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976922.1 900188 D 410289 CDS YP_976923.1 121636700 4696460 complement(900765..901544) 1 NC_008769.1 hypothetical protein 901544 4696460 BCG_0828c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976923.1 900765 R 410289 CDS YP_976924.1 121636701 4696978 901789..903207 1 NC_008769.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 903207 purB 4696978 purB Mycobacterium bovis BCG str. Pasteur 1173P2 adenylosuccinate lyase YP_976924.1 901789 D 410289 CDS YP_976925.1 121636702 4699226 903212..904456 1 NC_008769.1 cytochrome P450 126 cyp126 904456 cyp126 4699226 cyp126 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome P450 126 cyp126 YP_976925.1 903212 D 410289 CDS YP_976926.1 121636703 4695594 complement(904453..905073) 1 NC_008769.1 hypothetical protein 905073 4695594 BCG_0831c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976926.1 904453 R 410289 CDS YP_976927.1 121636704 4696944 905124..906017 1 NC_008769.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 906017 purC 4696944 purC Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_976927.1 905124 D 410289 CDS YP_976928.1 121636705 4699227 906014..908173 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, ptrB is split into 2 genes, ptrBa and ptrBb, due to a frameshift. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 2 bp insertion (*-gc) leads to a single product; protease II ptrB (oligopeptidase B) 908173 ptrB 4699227 ptrB Mycobacterium bovis BCG str. Pasteur 1173P2 protease II ptrB (oligopeptidase B) YP_976928.1 906014 D 410289 CDS YP_976929.1 121636706 4699224 complement(908601..910223) 1 NC_008769.1 multidrug resistance integral membrane efflux protein emrB 910223 emrB 4699224 emrB Mycobacterium bovis BCG str. Pasteur 1173P2 multidrug resistance integral membrane efflux protein emrB YP_976929.1 908601 R 410289 CDS YP_976930.1 121636707 4696773 910421..911107 1 NC_008769.1 hypothetical protein 911107 4696773 BCG_0835 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976930.1 910421 D 410289 CDS YP_976931.1 121636708 4695970 911123..911698 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (t-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808; hypothetical protein 911698 4695970 BCG_0836 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976931.1 911123 D 410289 CDS YP_976932.1 121636709 4697570 911716..912822 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis,and Mycobacterium bovis BCG Pasteur a frameshift due to a single base deletion (t-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808; hypothetical protein 912822 4697570 BCG_0837 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976932.1 911716 D 410289 CDS YP_976933.1 121636710 4697112 complement(912857..913246) 1 NC_008769.1 hypothetical protein 913246 4697112 BCG_0838c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976933.1 912857 R 410289 CDS YP_976934.1 121636711 4696953 913241..914200 1 NC_008769.1 Differs from Rv0787 by 1aa H269Y; hypothetical protein 914200 4696953 BCG_0839 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976934.1 913241 D 410289 CDS YP_976935.1 121636712 4696461 914306..914545 1 NC_008769.1 With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway; phosphoribosylformylglycinamidine synthase subunit PurS 914545 4696461 BCG_0840 Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoribosylformylglycinamidine synthase subunit PurS YP_976935.1 914306 D 410289 CDS YP_976936.1 121636713 4695934 914542..915216 1 NC_008769.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I 915216 purQ 4695934 purQ Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoribosylformylglycinamidine synthase I YP_976936.1 914542 D 410289 CDS YP_976937.1 121636714 4696058 complement(915233..915832) 1 NC_008769.1 hypothetical protein 915832 4696058 BCG_0842c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976937.1 915233 R 410289 CDS YP_976938.1 121636715 4696959 complement(915854..916582) 1 NC_008769.1 hypothetical protein 916582 4696959 BCG_0843c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976938.1 915854 R 410289 CDS YP_976939.1 121636716 4696464 complement(916579..917622) 1 NC_008769.1 hypothetical protein 917622 4696464 BCG_0844c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976939.1 916579 R 410289 CDS YP_976940.1 121636717 4696545 complement(917619..918428) 1 NC_008769.1 GntR family transcriptional regulator 918428 4696545 BCG_0845c Mycobacterium bovis BCG str. Pasteur 1173P2 GntR family transcriptional regulator YP_976940.1 917619 R 410289 CDS YP_976941.1 121636718 4696129 918501..918806 1 NC_008769.1 hypothetical protein 918806 4696129 BCG_0846 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976941.1 918501 D 410289 CDS YP_976942.1 121636719 4695937 complement(918919..919530) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (a-*) splits Rv0794c into 2 parts; oxidoreductase 919530 4695937 BCG_0847c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_976942.1 918919 R 410289 CDS YP_976943.1 121636720 4695990 complement(919518..920417) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (a-*) splits Rv0794c into 2 parts; oxidoreductase 920417 4695990 BCG_0848c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_976943.1 919518 R 410289 CDS YP_976944.1 121636721 4696459 920810..921904 1 NC_008769.1 Differs from Rv0797 by 1aa L111M; transposase for insertion sequence element IS1547 921904 4696459 BCG_0849 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase for insertion sequence element IS1547 YP_976944.1 920810 D 410289 CDS YP_976945.1 121636722 4697352 complement(921894..922691) 1 NC_008769.1 29 kDa antigen cfp29 922691 cfp29 4697352 cfp29 Mycobacterium bovis BCG str. Pasteur 1173P2 29 kDa antigen cfp29 YP_976945.1 921894 R 410289 CDS YP_976946.1 121636723 4695735 complement(922688..923695) 1 NC_008769.1 hypothetical protein 923695 4695735 BCG_0851c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976946.1 922688 R 410289 CDS YP_976947.1 121636724 4696923 923740..925041 1 NC_008769.1 catalyzes the removal of amino acids from the N termini of peptides; aminopeptidase 2 925041 pepC 4696923 pepC Mycobacterium bovis BCG str. Pasteur 1173P2 aminopeptidase 2 YP_976947.1 923740 D 410289 CDS YP_976948.1 121636725 4696120 925053..925400 1 NC_008769.1 hypothetical protein 925400 4696120 BCG_0853 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976948.1 925053 D 410289 CDS YP_976949.1 121636726 4696538 complement(925394..926050) 1 NC_008769.1 hypothetical protein 926050 4696538 BCG_0854c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976949.1 925394 R 410289 CDS YP_976950.1 121636727 4696724 926242..928506 1 NC_008769.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II 928506 purL 4696724 purL Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoribosylformylglycinamidine synthase II YP_976950.1 926242 D 410289 CDS YP_976951.1 121636728 4696435 928503..929132 1 NC_008769.1 hypothetical protein 929132 4696435 BCG_0856 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976951.1 928503 D 410289 CDS YP_976952.1 121636729 4697160 929253..930209 1 NC_008769.1 hypothetical protein 930209 4697160 BCG_0857 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976952.1 929253 D 410289 CDS YP_976953.1 121636730 4696198 complement(930154..931752) 1 NC_008769.1 udp-glucose-4-epimerase cpsY 931752 cpsY 4696198 cpsY Mycobacterium bovis BCG str. Pasteur 1173P2 udp-glucose-4-epimerase cpsY YP_976953.1 930154 R 410289 CDS YP_976954.1 121636731 4697925 932057..932446 1 NC_008769.1 hypothetical protein 932446 4697925 BCG_0859 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976954.1 932057 D 410289 CDS YP_976955.1 121636732 4695908 932533..934116 1 NC_008769.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 934116 purF 4695908 purF Mycobacterium bovis BCG str. Pasteur 1173P2 amidophosphoribosyltransferase YP_976955.1 932533 D 410289 CDS YP_976956.1 121636733 4696432 934147..935241 1 NC_008769.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 935241 purM 4696432 purM Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoribosylaminoimidazole synthetase YP_976956.1 934147 D 410289 CDS YP_976957.1 121636734 4696056 complement(935327..935509) 1 NC_008769.1 hypothetical protein 935509 4696056 BCG_0862c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976957.1 935327 R 410289 CDS YP_976958.1 121636735 4695579 complement(935656..936762) 1 NC_008769.1 hypothetical protein 936762 4695579 BCG_0863c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976958.1 935656 R 410289 CDS YP_976959.1 121636736 4695488 936845..937714 1 NC_008769.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 937714 4695488 BCG_0864 Mycobacterium bovis BCG str. Pasteur 1173P2 4-amino-4-deoxychorismate lyase YP_976959.1 936845 D 410289 CDS YP_976960.1 121636737 4695894 complement(937760..938440) 1 NC_008769.1 hypothetical protein 938440 4695894 BCG_0865c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976960.1 937760 R 410289 CDS YP_976961.1 121636738 4695759 complement(938603..938905) 1 NC_008769.1 hypothetical protein 938905 sseC2 4695759 sseC2 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976961.1 938603 R 410289 CDS YP_976962.1 121636739 4696755 complement(938907..939740) 1 NC_008769.1 thiosulfate sulfurtransferase cysA2 939740 cysA2 4696755 cysA2 Mycobacterium bovis BCG str. Pasteur 1173P2 thiosulfate sulfurtransferase cysA2 YP_976962.1 938907 R 410289 CDS YP_976963.1 121636740 4696054 complement(940033..940455) 1 NC_008769.1 thioredoxin thiX 940455 thiX 4696054 thiX Mycobacterium bovis BCG str. Pasteur 1173P2 thioredoxin thiX YP_976963.1 940033 R 410289 CDS YP_976964.1 121636741 4697960 complement(940452..941264) 1 NC_008769.1 hypothetical protein 941264 4697960 BCG_0869c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976964.1 940452 R 410289 CDS YP_976965.1 121636742 4697536 941394..942161 1 NC_008769.1 Differs from Rv0818 by 1aa P97L; transcriptional regulatory protein 942161 4697536 BCG_0870 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976965.1 941394 D 410289 CDS YP_976966.1 121636743 4695764 942158..943105 1 NC_008769.1 hypothetical protein 943105 4695764 BCG_0871 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976966.1 942158 D 410289 CDS YP_976967.1 121636744 4696609 943148..943660 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv and Mycobacterium Bovis phoT exists as a single gene. In Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (g-*), splits phoT into to parts phoTa and phoTb. Differs from Rv0820 by 1aa L35F; phosphate-transport ATP-binding protein ABC transporter phoTa 943660 phoTa 4696609 phoTa Mycobacterium bovis BCG str. Pasteur 1173P2 phosphate-transport ATP-binding protein ABC transporter phoTa YP_976967.1 943148 D 410289 CDS YP_976968.1 121636745 4698180 complement(943979..944620) 1 NC_008769.1 phosphate-transport system transcriptional regulatory protein phoY2 944620 phoY2 4698180 phoY2 Mycobacterium bovis BCG str. Pasteur 1173P2 phosphate-transport system transcriptional regulatory protein phoY2 YP_976968.1 943979 R 410289 CDS YP_976969.1 121636746 4697036 complement(944678..946732) 1 NC_008769.1 Differs from Rv0822c by 1aa P89H; hypothetical protein 946732 4697036 BCG_0875c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976969.1 944678 R 410289 CDS YP_976970.1 121636747 4696233 complement(946898..948067) 1 NC_008769.1 Differs from Rv0823c by 2aa C130G and L330F; transcriptional regulatory protein 948067 4696233 BCG_0876c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976970.1 946898 R 410289 CDS YP_976971.1 121636748 4696995 complement(948155..949171) 1 NC_008769.1 acyl-ACP desaturase 949171 desA1 4696995 desA1 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-ACP desaturase YP_976971.1 948155 R 410289 CDS YP_976972.1 121636749 4697858 complement(949333..949974) 1 NC_008769.1 hypothetical protein 949974 4697858 BCG_0878c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976972.1 949333 R 410289 CDS YP_976973.1 121636750 4695372 950055..951110 1 NC_008769.1 Differs from Rv0826 by 1aa Q294R and Mb0849 by 1aa E97G; hypothetical protein 951110 4695372 BCG_0879 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976973.1 950055 D 410289 CDS YP_976974.1 121636751 4695707 complement(951162..951554) 1 NC_008769.1 transcriptional regulatory protein 951554 4695707 BCG_0880c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_976974.1 951162 R 410289 CDS YP_976975.1 121636752 4695591 complement(951612..952034) 1 NC_008769.1 deaminase 952034 4695591 BCG_0881c Mycobacterium bovis BCG str. Pasteur 1173P2 deaminase YP_976975.1 951612 R 410289 CDS YP_976976.1 121636753 4695662 951996..952286 1 NC_008769.1 Differs from Rv0829 by 1aa G80A; transposase 952286 4695662 BCG_0882 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_976976.1 951996 D 410289 CDS YP_976977.1 121636754 4696092 952391..953296 1 NC_008769.1 hypothetical protein 953296 4696092 BCG_0883 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976977.1 952391 D 410289 CDS YP_976978.1 121636755 4696527 complement(953315..954130) 1 NC_008769.1 hypothetical protein 954130 4696527 BCG_0884c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976978.1 953315 R 410289 CDS YP_976979.1 121636756 4695947 955372..958104 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur PE-PGRS13 exists as a single gene. In Mycobacterium tuberculosis and Mycobacterium bovis, it is splitted in 2 genes PE-PGRS12 and PE-PGRS13; PE-PGRS family protein 958104 PE_PGRS13 4695947 PE_PGRS13 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_976979.1 955372 D 410289 CDS YP_976980.1 121636757 4697795 complement(958331..960979) 1 NC_008769.1 In Mycobacterium bovis, deletions of 143 bp and 9 bp (cgccgttgc-*), leads to a shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur (831 aa versus 882 aa); PE-PGRS family protein 960979 PE_PGRS14 4697795 PE_PGRS14 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_976980.1 958331 R 410289 CDS YP_976981.1 121636758 4697796 961447..962091 1 NC_008769.1 Differs from Rv0835 by 1aa G162D; lipoprotein lpqQ 962091 lpqQ 4697796 lpqQ Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqQ YP_976981.1 961447 D 410289 CDS YP_976982.1 121636759 4696678 complement(962704..963426) 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a single base transition (a-g) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (240 aa versus 217 aa); hypothetical protein 963426 4696678 BCG_0888c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976982.1 962704 R 410289 CDS YP_976983.1 121636760 4696154 complement(963497..964525) 1 NC_008769.1 hypothetical protein 964525 4696154 BCG_0889c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976983.1 963497 R 410289 CDS YP_976984.1 121636761 4695502 965214..965996 1 NC_008769.1 In Mycobacterium bovis, a 6bp insertion (*-cggccc) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (258 aa versus 256 aa). In Mycobacterium bovis BCG Pasteur, a 12bp insertion (compared to its homolog in Mycobacterium tuberculosis strain H37Rv) and a 6bp insertion (compared to its homolog in Mycobacterium bovis) leads to an even longer product (260 aa); lipoprotein lpqR 965996 lpqR 4695502 lpqR Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqR YP_976984.1 965214 D 410289 CDS YP_976985.1 121636762 4696679 966083..966895 1 NC_008769.1 hypothetical protein 966895 4696679 BCG_0891 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976985.1 966083 D 410289 CDS YP_976986.1 121636763 4695429 complement(966963..967823) 1 NC_008769.1 proline iminopeptidase pip 967823 pip 4695429 pip Mycobacterium bovis BCG str. Pasteur 1173P2 proline iminopeptidase pip YP_976986.1 966963 R 410289 CDS YP_976987.1 121636764 4699304 968099..968341 1 NC_008769.1 Differs from Rv0841 by 1aa F29V; hypothetical protein 968341 4699304 BCG_0893 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_976987.1 968099 D 410289 CDS YP_976988.1 121636765 4696946 968618..969910 1 NC_008769.1 integral membrane protein 969910 4696946 BCG_0894 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_976988.1 968618 D 410289 CDS YP_976989.1 121636766 4695952 969894..970898 1 NC_008769.1 Differs from Rv0843 by 1aa G191D and from Mb0866 by 1aa A309D; dehydrogenase 970898 4695952 BCG_0895 Mycobacterium bovis BCG str. Pasteur 1173P2 dehydrogenase YP_976989.1 969894 D 410289 CDS YP_976990.1 121636767 4695686 complement(970962..971612) 1 NC_008769.1 Differs from Mb0867c by 1aa A73P; nitrate/nitrite response transcriptional regulatory protein narL 971612 narL 4695686 narL Mycobacterium bovis BCG str. Pasteur 1173P2 nitrate/nitrite response transcriptional regulatory protein narL YP_976990.1 970962 R 410289 CDS YP_976991.1 121636768 4697468 971696..972973 1 NC_008769.1 Differs from Rv0845 by 1aa E219A; two component sensor kinase 972973 4697468 BCG_0897 Mycobacterium bovis BCG str. Pasteur 1173P2 two component sensor kinase YP_976991.1 971696 D 410289 CDS YP_976992.1 121636769 4697717 complement(973186..974700) 1 NC_008769.1 Differs from Mb0869c by 1aa Y411H; oxidase 974700 4697717 BCG_0898c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidase YP_976992.1 973186 R 410289 CDS YP_976993.1 121636770 4697647 974849..975241 1 NC_008769.1 Differs from Rv0847 by 1aa V128A; lipoprotein lpqS 975241 lpqS 4697647 lpqS Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqS YP_976993.1 974849 D 410289 CDS YP_976994.1 121636771 4696680 975444..976562 1 NC_008769.1 Differs from Rv0848 by 1aa S93G, and from Mb0871 by 1aa V137G; cysteine synthase a cysK2 976562 cysK2 4696680 cysK2 Mycobacterium bovis BCG str. Pasteur 1173P2 cysteine synthase a cysK2 YP_976994.1 975444 D 410289 CDS YP_976995.1 121636772 4695388 976562..977821 1 NC_008769.1 integral membrane transport protein 977821 4695388 BCG_0901 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane transport protein YP_976995.1 976562 D 410289 CDS YP_976996.1 121636773 4697340 977818..978150 1 NC_008769.1 transposase 978150 4697340 BCG_0902 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_976996.1 977818 D 410289 CDS YP_976997.1 121636774 4696791 complement(978147..978974) 1 NC_008769.1 Differs from Rv0851c by 1aa G59S and from Mb0874c by 1aa V84F; short chain dehydrogenase 978974 4696791 BCG_0903c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_976997.1 978147 R 410289 CDS YP_976998.1 121636775 4696017 979065..979901 1 NC_008769.1 fatty-acid-CoA ligase fadD16 979901 fadD16 4696017 fadD16 Mycobacterium bovis BCG str. Pasteur 1173P2 fatty-acid-CoA ligase fadD16 YP_976998.1 979065 D 410289 CDS YP_976999.1 121636776 4696314 complement(979942..981624) 1 NC_008769.1 pyruvate or indole-3-pyruvate decarboxylase pdc 981624 pdc 4696314 pdc Mycobacterium bovis BCG str. Pasteur 1173P2 pyruvate or indole-3-pyruvate decarboxylase pdc YP_976999.1 979942 R 410289 CDS YP_977000.1 121636777 4698421 981689..982132 1 NC_008769.1 hypothetical protein 982132 4698421 BCG_0906 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977000.1 981689 D 410289 CDS YP_977001.1 121636778 4697001 982138..983217 1 NC_008769.1 fatty-acid-CoA racemase far 983217 far 4697001 far Mycobacterium bovis BCG str. Pasteur 1173P2 fatty-acid-CoA racemase far YP_977001.1 982138 D 410289 CDS YP_977002.1 121636779 4695682 983330..983734 1 NC_008769.1 hypothetical protein 983734 4695682 BCG_0908 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977002.1 983330 D 410289 CDS YP_977003.1 121636780 4696557 983762..984235 1 NC_008769.1 hypothetical protein 984235 4696557 BCG_0909 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977003.1 983762 D 410289 CDS YP_977004.1 121636781 4696031 complement(984232..985425) 1 NC_008769.1 aminotransferase 985425 4696031 BCG_0910c Mycobacterium bovis BCG str. Pasteur 1173P2 aminotransferase YP_977004.1 984232 R 410289 CDS YP_977005.1 121636782 4696997 985582..986793 1 NC_008769.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 986793 fadA 4696997 fadA Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-CoA acetyltransferase YP_977005.1 985582 D 410289 CDS YP_977006.1 121636783 4695395 986798..988960 1 NC_008769.1 Differs from Rv0860 by 1aa T701A; fatty oxidation protein fadB 988960 fadB 4695395 fadB Mycobacterium bovis BCG str. Pasteur 1173P2 fatty oxidation protein fadB YP_977006.1 986798 D 410289 CDS YP_977007.1 121636784 4697224 complement(989028..990656) 1 NC_008769.1 Differs from Rv0861c by 1aa A258V; DNA helicase 990656 4697224 BCG_0913c Mycobacterium bovis BCG str. Pasteur 1173P2 DNA helicase YP_977007.1 989028 R 410289 CDS YP_977008.1 121636785 4697572 complement(990794..993064) 1 NC_008769.1 Differs from Rv0862c by 2aa F224L and S749L, and from Mb0885c by 1aa F224L; hypothetical protein 993064 4697572 BCG_0914c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977008.1 990794 R 410289 CDS YP_977009.1 121636786 4695688 993051..993332 1 NC_008769.1 hypothetical protein 993332 4695688 BCG_0915 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977009.1 993051 D 410289 CDS YP_977010.1 121636787 4696001 993416..993844 1 NC_008769.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 993844 moaC 4696001 moaC Mycobacterium bovis BCG str. Pasteur 1173P2 molybdenum cofactor biosynthesis protein MoaC YP_977010.1 993416 D 410289 CDS YP_977011.1 121636788 4695606 993841..994323 1 NC_008769.1 molybdopterin biosynthesis mog protein 994323 mog 4695606 mog Mycobacterium bovis BCG str. Pasteur 1173P2 molybdopterin biosynthesis mog protein YP_977011.1 993841 D 410289 CDS YP_977012.1 121636789 4698907 994320..994745 1 NC_008769.1 molybdenum cofactor biosynthesis protein e2 moaE2 994745 moaE2 4698907 moaE2 Mycobacterium bovis BCG str. Pasteur 1173P2 molybdenum cofactor biosynthesis protein e2 moaE2 YP_977012.1 994320 D 410289 CDS YP_977013.1 121636790 4698496 complement(994763..995986) 1 NC_008769.1 In Mycobacterium bovis, a 240 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur (327 aa versus 407 aa). Differs from Rv0867c by 1aa E235D; resuscitation-promoting factor rpfA 995986 rpfA 4698496 rpfA Mycobacterium bovis BCG str. Pasteur 1173P2 resuscitation-promoting factor rpfA YP_977013.1 994763 R 410289 CDS YP_977014.1 121636791 4697712 complement(996434..996712) 1 NC_008769.1 molybdenum cofactor biosynthesis protein D 2 moaD2 996712 moaD2 4697712 moaD2 Mycobacterium bovis BCG str. Pasteur 1173P2 molybdenum cofactor biosynthesis protein D 2 moaD2 YP_977014.1 996434 R 410289 CDS YP_977015.1 121636792 4698495 complement(996716..997798) 1 NC_008769.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 997798 moaA 4698495 moaA Mycobacterium bovis BCG str. Pasteur 1173P2 molybdenum cofactor biosynthesis protein A YP_977015.1 996716 R 410289 CDS YP_977016.1 121636793 4698507 complement(997795..998184) 1 NC_008769.1 Differs from Mb0894c by 1aa G29S; hypothetical protein 998184 4698507 BCG_0922c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977016.1 997795 R 410289 CDS YP_977017.1 121636794 4696925 998349..998756 1 NC_008769.1 cold shock-like protein B cspB 998756 cspB 4696925 cspB Mycobacterium bovis BCG str. Pasteur 1173P2 cold shock-like protein B cspB YP_977017.1 998349 D 410289 CDS YP_977018.1 121636795 4697910 complement(998875..1000704) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, a 9 bp in-frame insertion (compared to Mycobacterium tuberculosis strain H37Rv), leads to a lightly longer product (609 aa versus 606 aa). In Mycobacterium bovis, an additional 3 bp in-frame deletion (compared to Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur) leads to a product of 608 aa; PE-PGRS family protein 1000704 PE_PGRS15 4697910 PE_PGRS15 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977018.1 998875 R 410289 CDS YP_977019.1 121636796 4697797 1000965..1002917 1 NC_008769.1 acyl-CoA dehydrogenase fadE10 1002917 fadE10 4697797 fadE10 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE10 YP_977019.1 1000965 D 410289 CDS YP_977020.1 121636797 4695873 complement(1003006..1004166) 1 NC_008769.1 hypothetical protein 1004166 4695873 BCG_0926c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977020.1 1003006 R 410289 CDS YP_977021.1 121636798 4697494 complement(1004266..1004754) 1 NC_008769.1 hypothetical protein 1004754 4697494 BCG_0927c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977021.1 1004266 R 410289 CDS YP_977022.1 121636799 4696439 complement(1004751..1006397) 1 NC_008769.1 Differs from Mb0900c by 1aa D26G; hypothetical protein 1006397 4696439 BCG_0928c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977022.1 1004751 R 410289 CDS YP_977023.1 121636800 4696916 1006535..1007323 1 NC_008769.1 hypothetical protein 1007323 4696916 BCG_0929 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977023.1 1006535 D 410289 CDS YP_977024.1 121636801 4697552 complement(1007332..1008660) 1 NC_008769.1 In Mycobacterium bovis and Mycobaterium bovis BCG Pasteur, a single base deletion (a-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (438 aa versus 443 aa). Differs from Rv0878c and Mb0902c by 1aa K436Q; PPE family protein 1008660 PPE13 4697552 PPE13 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977024.1 1007332 R 410289 CDS YP_977025.1 121636802 4697236 complement(1008938..1009213) 1 NC_008769.1 hypothetical protein 1009213 4697236 BCG_0931c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977025.1 1008938 R 410289 CDS YP_977026.1 121636803 4696924 1009391..1009822 1 NC_008769.1 MarR family transcriptional regulator 1009822 4696924 BCG_0932 Mycobacterium bovis BCG str. Pasteur 1173P2 MarR family transcriptional regulator YP_977026.1 1009391 D 410289 CDS YP_977027.1 121636804 4695977 1009819..1010685 1 NC_008769.1 rRNA methyltransferase 1010685 4695977 BCG_0933 Mycobacterium bovis BCG str. Pasteur 1173P2 rRNA methyltransferase YP_977027.1 1009819 D 410289 CDS YP_977028.1 121636805 4696241 1010682..1010966 1 NC_008769.1 hypothetical protein 1010966 4696241 BCG_0934 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977028.1 1010682 D 410289 CDS YP_977029.1 121636806 4696341 complement(1010963..1011724) 1 NC_008769.1 hypothetical protein 1011724 4696341 BCG_0935c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977029.1 1010963 R 410289 CDS YP_977030.1 121636807 4696541 complement(1011881..1013011) 1 NC_008769.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase 1013011 serC 4696541 serC Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoserine aminotransferase YP_977030.1 1011881 R 410289 CDS YP_977031.1 121636808 4696251 1013219..1014241 1 NC_008769.1 hypothetical protein 1014241 4696251 BCG_0937 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977031.1 1013219 D 410289 CDS YP_977032.1 121636809 4696398 1014260..1015987 1 NC_008769.1 NADPH:adrenodoxin oxidoreductase fprB 1015987 fprB 4696398 fprB Mycobacterium bovis BCG str. Pasteur 1173P2 NADPH:adrenodoxin oxidoreductase fprB YP_977032.1 1014260 D 410289 CDS YP_977033.1 121636810 4697656 complement(1015970..1016428) 1 NC_008769.1 hypothetical protein 1016428 4697656 BCG_0939c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977033.1 1015970 R 410289 CDS YP_977034.1 121636811 4696587 1017690..1019162 1 NC_008769.1 hypothetical protein 1019162 4696587 BCG_0940 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977034.1 1017690 D 410289 CDS YP_977035.1 121636812 4696575 complement(1019197..1020318) 1 NC_008769.1 forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; citrate synthase 2 1020318 citA 4696575 citA Mycobacterium bovis BCG str. Pasteur 1173P2 citrate synthase 2 YP_977035.1 1019197 R 410289 CDS YP_977036.1 121636813 4697911 complement(1020405..1023053) 1 NC_008769.1 Differs from Rv0890c by 1aa A866P; LuxR family transcriptional regulator 1023053 4697911 BCG_0942c Mycobacterium bovis BCG str. Pasteur 1173P2 LuxR family transcriptional regulator YP_977036.1 1020405 R 410289 CDS YP_977037.1 121636814 4696599 complement(1023055..1023912) 1 NC_008769.1 Differs from Rv0891c by 1aa G37V; transcriptional regulatory protein 1023912 4696599 BCG_0943c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977037.1 1023055 R 410289 CDS YP_977038.1 121636815 4696652 1024310..1025797 1 NC_008769.1 monooxygenase 1025797 4696652 BCG_0944 Mycobacterium bovis BCG str. Pasteur 1173P2 monooxygenase YP_977038.1 1024310 D 410289 CDS YP_977039.1 121636816 4696630 complement(1025775..1026752) 1 NC_008769.1 hypothetical protein 1026752 4696630 BCG_0945c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977039.1 1025775 R 410289 CDS YP_977040.1 121636817 4696683 1026981..1028162 1 NC_008769.1 LuxR family transcriptional regulator 1028162 4696683 BCG_0946 Mycobacterium bovis BCG str. Pasteur 1173P2 LuxR family transcriptional regulator YP_977040.1 1026981 D 410289 CDS YP_977041.1 121636818 4696714 1028239..1029756 1 NC_008769.1 hypothetical protein 1029756 4696714 BCG_0947 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977041.1 1028239 D 410289 CDS YP_977042.1 121636819 4696774 1029946..1031241 1 NC_008769.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 1031241 gltA 4696774 gltA Mycobacterium bovis BCG str. Pasteur 1173P2 type II citrate synthase YP_977042.1 1029946 D 410289 CDS YP_977043.1 121636820 4696570 complement(1031282..1032889) 1 NC_008769.1 oxidoreductase 1032889 4696570 BCG_0949c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_977043.1 1031282 R 410289 CDS YP_977044.1 121636821 4696859 complement(1032915..1033178) 1 NC_008769.1 hypothetical protein 1033178 4696859 BCG_0950c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977044.1 1032915 R 410289 CDS YP_977045.1 121636822 4696918 1033286..1034266 1 NC_008769.1 outer membrane protein A ompA 1034266 ompA 4696918 ompA Mycobacterium bovis BCG str. Pasteur 1173P2 outer membrane protein A ompA YP_977045.1 1033286 D 410289 CDS YP_977046.1 121636823 4696326 1034279..1034431 1 NC_008769.1 hypothetical protein 1034431 4696326 BCG_0952 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977046.1 1034279 D 410289 CDS YP_977047.1 121636824 4697058 1034431..1034958 1 NC_008769.1 hypothetical protein 1034958 4697058 BCG_0953 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977047.1 1034431 D 410289 CDS YP_977048.1 121636825 4697086 complement(1034975..1036315) 1 NC_008769.1 two component sensor histidine kinase prrB 1036315 prrB 4697086 prrB Mycobacterium bovis BCG str. Pasteur 1173P2 two component sensor histidine kinase prrB YP_977048.1 1034975 R 410289 CDS YP_977049.1 121636826 4697277 complement(1036326..1037036) 1 NC_008769.1 two component response transcriptional regulatory protein prrA 1037036 prrA 4697277 prrA Mycobacterium bovis BCG str. Pasteur 1173P2 two component response transcriptional regulatory protein prrA YP_977049.1 1036326 R 410289 CDS YP_977050.1 121636827 4697276 complement(1037167..1038654) 1 NC_008769.1 acetyl-coenzyme A carboxylase carboxyl transferase (subunit beta) accD3 1038654 accD3 4697276 accD3 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-coenzyme A carboxylase carboxyl transferase (subunit beta) accD3 YP_977050.1 1037167 R 410289 CDS YP_977051.1 121636828 4698644 1038681..1039412 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1039412 echA6 4698644 echA6 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_977051.1 1038681 D 410289 CDS YP_977052.1 121636829 4697107 1039418..1040536 1 NC_008769.1 hypothetical protein 1040536 4697107 BCG_0958 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977052.1 1039418 D 410289 CDS YP_977053.1 121636830 4697187 1040629..1042209 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur and in Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Rv0907 by 1aa, L322P; hypothetical protein 1042209 4697187 BCG_0959 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977053.1 1040629 D 410289 CDS YP_977054.1 121636831 4697208 1042206..1044599 1 NC_008769.1 metal cation transporter atpase P-type ctpE 1044599 ctpE 4697208 ctpE Mycobacterium bovis BCG str. Pasteur 1173P2 metal cation transporter atpase P-type ctpE YP_977054.1 1042206 D 410289 CDS YP_977055.1 121636832 4696356 1045156..1045335 1 NC_008769.1 Differs from Rv0909 by 1aa, Q45H; hypothetical protein 1045335 4696356 BCG_0961 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977055.1 1045156 D 410289 CDS YP_977056.1 121636833 4697226 1045341..1045775 1 NC_008769.1 hypothetical protein 1045775 4697226 BCG_0962 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977056.1 1045341 D 410289 CDS YP_977057.1 121636834 4697213 1045873..1046646 1 NC_008769.1 hypothetical protein 1046646 4697213 BCG_0963 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977057.1 1045873 D 410289 CDS YP_977058.1 121636835 4697354 1046711..1047160 1 NC_008769.1 hypothetical protein 1047160 4697354 BCG_0964 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977058.1 1046711 D 410289 CDS YP_977059.1 121636836 4697274 complement(1047692..1049200) 1 NC_008769.1 Differs from Rv0913c by 1aa P233L; dioxygenase 1049200 4697274 BCG_0965c Mycobacterium bovis BCG str. Pasteur 1173P2 dioxygenase YP_977059.1 1047692 R 410289 CDS YP_977060.1 121636837 4697479 complement(1049202..1050440) 1 NC_008769.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 1050440 4697479 BCG_0966c Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-CoA acetyltransferase YP_977060.1 1049202 R 410289 CDS YP_977061.1 121636838 4697589 complement(1050533..1051804) 1 NC_008769.1 PPE family protein 1051804 PPE14 4697589 PPE14 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977061.1 1050533 R 410289 CDS YP_977062.1 121636839 4697237 complement(1051819..1052118) 1 NC_008769.1 PE family protein 1052118 PE7 4697237 PE7 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_977062.1 1051819 R 410289 CDS YP_977063.1 121636840 4696204 1052562..1054343 1 NC_008769.1 glycine betaine transport integral membrane protein betP 1054343 betP 4696204 betP Mycobacterium bovis BCG str. Pasteur 1173P2 glycine betaine transport integral membrane protein betP YP_977063.1 1052562 D 410289 CDS YP_977064.1 121636841 4695658 1054686..1055162 1 NC_008769.1 Differs from Rv0918 by 1aa, G46S; hypothetical protein 1055162 4695658 BCG_0970 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977064.1 1054686 D 410289 CDS YP_977065.1 121636842 4697674 1055159..1055659 1 NC_008769.1 hypothetical protein 1055659 4697674 BCG_0971 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977065.1 1055159 D 410289 CDS YP_977066.1 121636843 4697082 complement(1055972..1057291) 1 NC_008769.1 Differs from Rv0920c by 1aa, E249D; transposase 1057291 4697082 BCG_0972c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_977066.1 1055972 R 410289 CDS YP_977067.1 121636844 4697653 1057579..1058160 1 NC_008769.1 resolvase 1058160 4697653 BCG_0973 Mycobacterium bovis BCG str. Pasteur 1173P2 resolvase YP_977067.1 1057579 D 410289 CDS YP_977068.1 121636845 4697695 1058160..1059812 1 NC_008769.1 transposase 1059812 4697695 BCG_0974 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_977068.1 1058160 D 410289 CDS YP_977069.1 121636846 4697955 complement(1059988..1061052) 1 NC_008769.1 hypothetical protein 1061052 4697955 BCG_0975c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977069.1 1059988 R 410289 CDS YP_977070.1 121636847 4698253 complement(1061053..1062339) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur, Rv0924c and Rv0925c exist as 2 genes. In Mycobacterium bovis, a single base deletion (t-*) leads to a single product, Mb0948c. Differs from Rv0924c by 1aa, A216P; manganese transport protein MntH 1062339 mntH 4698253 mntH Mycobacterium bovis BCG str. Pasteur 1173P2 manganese transport protein MntH YP_977070.1 1061053 R 410289 CDS YP_977071.1 121636848 4698505 complement(1062371..1063108) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur, Rv0924c and Rv0925c exist as 2 genes. In Mycobacterium bovis, a single base deletion (t-*) leads to a single product,Mb0948c; divalent cation-transport integral membrane protein mntH 1063108 4698505 BCG_0977c Mycobacterium bovis BCG str. Pasteur 1173P2 divalent cation-transport integral membrane protein mntH YP_977071.1 1062371 R 410289 CDS YP_977072.1 121636849 4698006 complement(1063185..1064261) 1 NC_008769.1 hypothetical protein 1064261 4698006 BCG_0978c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977072.1 1063185 R 410289 CDS YP_977073.1 121636850 4697633 complement(1064315..1065106) 1 NC_008769.1 short chain dehydrogenase 1065106 4697633 BCG_0979c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_977073.1 1064315 R 410289 CDS YP_977074.1 121636851 4697553 1065378..1066490 1 NC_008769.1 periplasmic phosphate-binding lipoprotein pstS3 1066490 pstS3 4697553 pstS3 Mycobacterium bovis BCG str. Pasteur 1173P2 periplasmic phosphate-binding lipoprotein pstS3 YP_977074.1 1065378 D 410289 CDS YP_977075.1 121636852 4697314 1066503..1067477 1 NC_008769.1 phosphate-transport integral membrane ABC transporter pstC2 1067477 pstC2 4697314 pstC2 Mycobacterium bovis BCG str. Pasteur 1173P2 phosphate-transport integral membrane ABC transporter pstC2 YP_977075.1 1066503 D 410289 CDS YP_977076.1 121636853 4695695 1067474..1068388 1 NC_008769.1 Differs from Rv0930 by 1aa, T5M; phosphate-transport integral membrane ABC transporter pstA1 1068388 pstA1 4695695 pstA1 Mycobacterium bovis BCG str. Pasteur 1173P2 phosphate-transport integral membrane ABC transporter pstA1 YP_977076.1 1067474 D 410289 CDS YP_977077.1 121636854 4696825 complement(1068395..1069504) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-t) splits pknD into 2 parts, pknDa and pknDb; Ser/Thr protein kinase 1069504 pknDb 4696825 pknDb Mycobacterium bovis BCG str. Pasteur 1173P2 Ser/Thr protein kinase YP_977077.1 1068395 R 410289 CDS YP_977078.1 121636855 4696551 complement(1069515..1070390) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-t) splits pknD into 2 parts, pknDa and pknDb; Ser/Thr protein kinase 1070390 pknDa 4696551 pknDa Mycobacterium bovis BCG str. Pasteur 1173P2 Ser/Thr protein kinase YP_977078.1 1069515 R 410289 CDS YP_977079.1 121636856 4696550 complement(1070412..1071524) 1 NC_008769.1 Differs from Rv0932c by 1aa, A115S; periplasmic phosphate-binding lipoprotein pstS2 1071524 pstS2 4696550 pstS2 Mycobacterium bovis BCG str. Pasteur 1173P2 periplasmic phosphate-binding lipoprotein pstS2 YP_977079.1 1070412 R 410289 CDS YP_977080.1 121636857 4695698 1071740..1071955 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base insertion (*-t, position 1041448-1041449) splits pstB into 2 parts, pstBa and pstBb; hypothetical protein 1071955 pstBa 4695698 pstBa Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977080.1 1071740 D 410289 CDS YP_977081.1 121636858 4696827 1071930..1072571 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base insertion (*-t, position 1041448-1041449) splits pstB into 2 parts, pstBa and pstBb; phosphate-transport protein ABC transporter pstBb 1072571 pstBb 4696827 pstBb Mycobacterium bovis BCG str. Pasteur 1173P2 phosphate-transport protein ABC transporter pstBb YP_977081.1 1071930 D 410289 CDS YP_977082.1 121636859 4696828 1072592..1073716 1 NC_008769.1 Differs from Rv0934 by 1aa, A352V; periplasmic phosphate-binding lipoprotein pstS1 1073716 pstS1 4696828 pstS1 Mycobacterium bovis BCG str. Pasteur 1173P2 periplasmic phosphate-binding lipoprotein pstS1 YP_977082.1 1072592 D 410289 CDS YP_977083.1 121636860 4695697 1073776..1074792 1 NC_008769.1 phosphate ABC transporter transmembrane protein 1074792 pstC1 4695697 pstC1 Mycobacterium bovis BCG str. Pasteur 1173P2 phosphate ABC transporter transmembrane protein YP_977083.1 1073776 D 410289 CDS YP_977084.1 121636861 4695694 1074794..1075699 1 NC_008769.1 phosphate ABC transporter transmembrane protein 1075699 pstA2 4695694 pstA2 Mycobacterium bovis BCG str. Pasteur 1173P2 phosphate ABC transporter transmembrane protein YP_977084.1 1074794 D 410289 CDS YP_977085.1 121636862 4696826 complement(1075676..1076497) 1 NC_008769.1 hypothetical protein 1076497 4696826 BCG_0991c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977085.1 1075676 R 410289 CDS YP_977086.1 121636863 4697382 1076613..1078892 1 NC_008769.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA and has been shown to have polymerase activity; ATP-dependent DNA ligase 1078892 4697382 BCG_0992 Mycobacterium bovis BCG str. Pasteur 1173P2 ATP-dependent DNA ligase YP_977086.1 1076613 D 410289 CDS YP_977087.1 121636864 4697384 1078889..1080823 1 NC_008769.1 bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase + cyclase/dehydrase 1080823 4697384 BCG_0993 Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase + cyclase/dehydrase YP_977087.1 1078889 D 410289 CDS YP_977088.1 121636865 4697379 complement(1081070..1081936) 1 NC_008769.1 oxidoreductase 1081936 4697379 BCG_0994c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_977088.1 1081070 R 410289 CDS YP_977089.1 121636866 4697472 complement(1082021..1082794) 1 NC_008769.1 hypothetical protein 1082794 4697472 BCG_0995c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977089.1 1082021 R 410289 CDS YP_977090.1 121636867 4697366 1082837..1083115 1 NC_008769.1 hypothetical protein 1083115 4697366 BCG_0996 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977090.1 1082837 D 410289 CDS YP_977091.1 121636868 4697375 complement(1083173..1084213) 1 NC_008769.1 monooxygenase 1084213 4697375 BCG_0997c Mycobacterium bovis BCG str. Pasteur 1173P2 monooxygenase YP_977091.1 1083173 R 410289 CDS YP_977092.1 121636869 4697368 1084242..1084718 1 NC_008769.1 formamidopyrimidine-DNA glycosylase 1084718 4697368 BCG_0998 Mycobacterium bovis BCG str. Pasteur 1173P2 formamidopyrimidine-DNA glycosylase YP_977092.1 1084242 D 410289 CDS YP_977093.1 121636870 4697370 1084724..1085485 1 NC_008769.1 Differs from Rv0945 by 1aa, G180R; short chain dehydrogenase 1085485 4697370 BCG_0999 Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_977093.1 1084724 D 410289 CDS YP_977094.1 121636871 4697144 complement(1085501..1087162) 1 NC_008769.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1087162 pgi 4697144 pgi Mycobacterium bovis BCG str. Pasteur 1173P2 glucose-6-phosphate isomerase YP_977094.1 1085501 R 410289 CDS YP_977095.1 121636872 4698545 complement(1087777..1088007) 1 NC_008769.1 mycolyl transferase 1088007 4698545 BCG_1001c Mycobacterium bovis BCG str. Pasteur 1173P2 mycolyl transferase YP_977095.1 1087777 R 410289 CDS YP_977096.1 121636873 4697189 complement(1088123..1088440) 1 NC_008769.1 hypothetical protein 1088440 4697189 BCG_1002c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977096.1 1088123 R 410289 CDS YP_977097.1 121636874 4696957 1088737..1091052 1 NC_008769.1 ATP dependent DNA helicase uvrD1 1091052 uvrD1 4696957 uvrD1 Mycobacterium bovis BCG str. Pasteur 1173P2 ATP dependent DNA helicase uvrD1 YP_977097.1 1088737 D 410289 CDS YP_977098.1 121636875 4697229 complement(1091133..1092131) 1 NC_008769.1 hypothetical protein 1092131 4697229 BCG_1004c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977098.1 1091133 R 410289 CDS YP_977099.1 121636876 4695639 1092441..1093604 1 NC_008769.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1093604 sucC 4695639 sucC Mycobacterium bovis BCG str. Pasteur 1173P2 succinyl-CoA synthetase subunit beta YP_977099.1 1092441 D 410289 CDS YP_977100.1 121636877 4696766 1093617..1094528 1 NC_008769.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 1094528 sucD 4696766 sucD Mycobacterium bovis BCG str. Pasteur 1173P2 succinyl-CoA synthetase subunit alpha YP_977100.1 1093617 D 410289 CDS YP_977101.1 121636878 4696767 complement(1094591..1095439) 1 NC_008769.1 Differs from Rv0953c and Mb0978c by 1aa, A50T; oxidoreductase 1095439 4696767 BCG_1007c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_977101.1 1094591 R 410289 CDS YP_977102.1 121636879 4696030 1095604..1096515 1 NC_008769.1 hypothetical protein 1096515 4696030 BCG_1008 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977102.1 1095604 D 410289 CDS YP_977103.1 121636880 4696002 1096555..1097922 1 NC_008769.1 integral membrane protein 1097922 4696002 BCG_1009 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_977103.1 1096555 D 410289 CDS YP_977104.1 121636881 4695999 1098038..1098685 1 NC_008769.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 1098685 purN 4695999 purN Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoribosylglycinamide formyltransferase YP_977104.1 1098038 D 410289 CDS YP_977105.1 121636882 4696057 1098682..1100253 1 NC_008769.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1100253 purH 4696057 purH Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_977105.1 1098682 D 410289 CDS YP_977106.1 121636883 4696433 1100360..1101739 1 NC_008769.1 Differs from Rv0958 by 1aa, P274S; magnesium chelatase 1101739 4696433 BCG_1012 Mycobacterium bovis BCG str. Pasteur 1173P2 magnesium chelatase YP_977106.1 1100360 D 410289 CDS YP_977107.1 121636884 4695555 1101732..1103750 1 NC_008769.1 hypothetical protein 1103750 4695555 BCG_1013 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977107.1 1101732 D 410289 CDS YP_977108.1 121636885 4696930 1103804..1104025 1 NC_008769.1 antitoxin 1104025 4696930 BCG_1013A Mycobacterium bovis BCG str. Pasteur 1173P2 antitoxin YP_977108.1 1103804 D 410289 CDS YP_977109.1 121636886 4696039 1104022..1104405 1 NC_008769.1 hypothetical protein 1104405 4696039 BCG_1014 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977109.1 1104022 D 410289 CDS YP_977110.1 121636887 4695997 1104551..1104898 1 NC_008769.1 integral membrane protein 1104898 4695997 BCG_1015 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_977110.1 1104551 D 410289 CDS YP_977111.1 121636888 4696254 complement(1104917..1105591) 1 NC_008769.1 Differs from Rv0962c by 1aa, L186P; lipoprotein lprP 1105591 lprP 4696254 lprP Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lprP YP_977111.1 1104917 R 410289 CDS YP_977112.1 121636889 4698592 complement(1105774..1106574) 1 NC_008769.1 Differs from Rv0963c and Mb0988c by 1aa, S258G; hypothetical protein 1106574 4698592 BCG_1017c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977112.1 1105774 R 410289 CDS YP_977113.1 121636890 4696215 complement(1106673..1107155) 1 NC_008769.1 Differs from Rv0964c by 1aa, T124P; hypothetical protein 1107155 4696215 BCG_1018c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977113.1 1106673 R 410289 CDS YP_977114.1 121636891 4696219 complement(1107255..1107674) 1 NC_008769.1 Differs from Rv0965c by 1aa, H94R; hypothetical protein 1107674 4696219 BCG_1019c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977114.1 1107255 R 410289 CDS YP_977115.1 121636892 4695646 complement(1107710..1108312) 1 NC_008769.1 Differs from Rv0966c by 2aa, A175V, G186W; hypothetical protein 1108312 4695646 BCG_1020c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977115.1 1107710 R 410289 CDS YP_977116.1 121636893 4697033 1108451..1108810 1 NC_008769.1 hypothetical protein 1108810 4697033 BCG_1021 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977116.1 1108451 D 410289 CDS YP_977117.1 121636894 4697050 1108867..1109163 1 NC_008769.1 hypothetical protein 1109163 4697050 BCG_1022 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977117.1 1108867 D 410289 CDS YP_977118.1 121636895 4696984 1109219..1111531 1 NC_008769.1 Differs from Rv0969 by 1aa, N484D; metal cation transporter P-type atpase ctpV 1111531 ctpV 4696984 ctpV Mycobacterium bovis BCG str. Pasteur 1173P2 metal cation transporter P-type atpase ctpV YP_977118.1 1109219 D 410289 CDS YP_977119.1 121636896 4697951 1111528..1112160 1 NC_008769.1 integral membrane protein 1112160 4697951 BCG_1024 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_977119.1 1111528 D 410289 CDS YP_977120.1 121636897 4696218 complement(1112251..1113060) 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1113060 echA7 4696218 echA7 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_977120.1 1112251 R 410289 CDS YP_977121.1 121636898 4696186 complement(1113060..1114226) 1 NC_008769.1 Differs from Rv0972c by 1aa, H236Q; acyl-CoA dehydrogenase fadE12 1114226 fadE12 4696186 fadE12 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE12 YP_977121.1 1113060 R 410289 CDS YP_977122.1 121636899 4695874 complement(1114223..1116226) 1 NC_008769.1 Differs from Rv0973c by 1aa, F220I; acetyl-/propionyl-coenzyme A carboxylase alpha chain subunit alpha accA2 1116226 accA2 4695874 accA2 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-/propionyl-coenzyme A carboxylase alpha chain subunit alpha accA2 YP_977122.1 1114223 R 410289 CDS YP_977123.1 121636900 4698782 complement(1116232..1117821) 1 NC_008769.1 Differs from Rv0974c by 1aa, K51N; acetyl-/propionyl-coa carboxylase subunit beta accD2 1117821 accD2 4698782 accD2 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-/propionyl-coa carboxylase subunit beta accD2 YP_977123.1 1116232 R 410289 CDS YP_977124.1 121636901 4698803 complement(1117824..1118972) 1 NC_008769.1 In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG pasteur; acyl-coa dehydrogenase fadE13 1118972 fadE13 4698803 fadE13 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-coa dehydrogenase fadE13 YP_977124.1 1117824 R 410289 CDS YP_977125.1 121636902 4695875 complement(1118969..1120651) 1 NC_008769.1 hypothetical protein 1120651 4695875 BCG_1030c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977125.1 1118969 R 410289 CDS YP_977126.1 121636903 4696955 1120850..1123621 1 NC_008769.1 PE-PGRS family protein 1123621 PE_PGRS16 4696955 PE_PGRS16 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977126.1 1120850 D 410289 CDS YP_977127.1 121636904 4697798 complement(1123838..1124845) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterim bovis BCG Pasteur, a 115 bp to 127 bp substitution leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (335 aa versus 331 aa); PE-PGRS family protein 1124845 PE_PGRS17 4697798 PE_PGRS17 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977127.1 1123838 R 410289 CDS YP_977128.1 121636905 4697719 complement(1125159..1125353) 1 NC_008769.1 hypothetical protein 1125353 4697719 BCG_1033c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977128.1 1125159 R 410289 CDS YP_977129.1 121636906 4696844 1125375..1125548 1 NC_008769.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1125548 rpmF 4696844 rpmF Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L32 YP_977129.1 1125375 D 410289 CDS YP_977130.1 121636907 4696786 complement(1125567..1126940) 1 NC_008769.1 Differs from Rv0980c by 1aa, Q43H, and from Mb1006c by 1aa, A270T; PE-PGRS family protein 1126940 PE_PGRS18 4696786 PE_PGRS18 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977130.1 1125567 R 410289 CDS YP_977131.1 121636908 4697720 1127305..1127997 1 NC_008769.1 Differs from Rv0981 by 1aa, S70G; two component response transcriptional regulatory protein MprA 1127997 mprA 4697720 mprA Mycobacterium bovis BCG str. Pasteur 1173P2 two component response transcriptional regulatory protein MprA YP_977131.1 1127305 D 410289 CDS YP_977132.1 121636909 4696126 1127997..1129511 1 NC_008769.1 Differs from Rv0982 by 1aa, H339L; two component sensor kinase mprB 1129511 mprB 4696126 mprB Mycobacterium bovis BCG str. Pasteur 1173P2 two component sensor kinase mprB YP_977132.1 1127997 D 410289 CDS YP_977133.1 121636910 4696127 1129555..1130949 1 NC_008769.1 Differs from Rv0983 by 1aa, P390L; serine protease 1130949 4696127 BCG_1038 Mycobacterium bovis BCG str. Pasteur 1173P2 serine protease YP_977133.1 1129555 D 410289 CDS YP_977134.1 121636911 4695982 1130949..1131494 1 NC_008769.1 pterin-4-alpha-carbinolamine dehydratase moaB2 1131494 moaB2 4695982 moaB2 Mycobacterium bovis BCG str. Pasteur 1173P2 pterin-4-alpha-carbinolamine dehydratase moaB2 YP_977134.1 1130949 D 410289 CDS YP_977135.1 121636912 4695603 complement(1131514..1131969) 1 NC_008769.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 1131969 mscL 4695603 mscL Mycobacterium bovis BCG str. Pasteur 1173P2 large-conductance mechanosensitive channel YP_977135.1 1131514 R 410289 CDS YP_977136.1 121636913 4697734 1132292..1133038 1 NC_008769.1 Differs from Rv0986 by 1aa, L228V; adhesion component transport atp-binding protein ABC transporter 1133038 4697734 BCG_1041 Mycobacterium bovis BCG str. Pasteur 1173P2 adhesion component transport atp-binding protein ABC transporter YP_977136.1 1132292 D 410289 CDS YP_977137.1 121636914 4695392 1133031..1135598 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur and Mycobacterium tuberculosis strain H37Rv, Rv0987 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a stop codon that splits Rv0987 in two parts, Mb1013 and Mb1014. Differs from Rv0987 by 1aa, V717F; adhesion component transport transmembrane protein 1135598 4695392 BCG_1042 Mycobacterium bovis BCG str. Pasteur 1173P2 adhesion component transport transmembrane protein YP_977137.1 1133031 D 410289 CDS YP_977138.1 121636915 4695975 1135605..1136765 1 NC_008769.1 Differs from Rv0988 by 2aa, I57V, D135Y; hypothetical protein 1136765 4695975 BCG_1043 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977138.1 1135605 D 410289 CDS YP_977139.1 121636916 4696693 complement(1136894..1137871) 1 NC_008769.1 Differs from Rv0989c by 1aa, V321I; polyprenyl-diphosphate synthase grcC2 1137871 grcC2 4696693 grcC2 Mycobacterium bovis BCG str. Pasteur 1173P2 polyprenyl-diphosphate synthase grcC2 YP_977139.1 1136894 R 410289 CDS YP_977140.1 121636917 4698392 complement(1137932..1138588) 1 NC_008769.1 Differs from Rv0990c by 1aa, A54S; hypothetical protein 1138588 4698392 BCG_1045c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977140.1 1137932 R 410289 CDS YP_977141.1 121636918 4696238 complement(1138661..1138993) 1 NC_008769.1 hypothetical protein 1138993 4696238 BCG_1046c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977141.1 1138661 R 410289 CDS YP_977142.1 121636919 4696940 complement(1139067..1139660) 1 NC_008769.1 Differs from Rv0992c by 2aa, I3M, S135G, and from Mb1019c by 1aa, S135G; hypothetical protein 1139660 4696940 BCG_1047c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977142.1 1139067 R 410289 CDS YP_977143.1 121636920 4696360 1139761..1140681 1 NC_008769.1 Differs from Rv0993 by 1aa, R235Q; UTP--glucose-1-phosphate uridylyltransferase galU 1140681 galU 4696360 galU Mycobacterium bovis BCG str. Pasteur 1173P2 UTP--glucose-1-phosphate uridylyltransferase galU YP_977143.1 1139761 D 410289 CDS YP_977144.1 121636921 4695745 1140758..1142038 1 NC_008769.1 Differs from Rv0994 by 1aa, G230C; molybdopterin biosynthesis protein moeA1 1142038 moeA1 4695745 moeA1 Mycobacterium bovis BCG str. Pasteur 1173P2 molybdopterin biosynthesis protein moeA1 YP_977144.1 1140758 D 410289 CDS YP_977145.1 121636922 4695570 1142101..1142712 1 NC_008769.1 ribosomal-protein-alanine acetyltransferase rimJ 1142712 rimJ 4695570 rimJ Mycobacterium bovis BCG str. Pasteur 1173P2 ribosomal-protein-alanine acetyltransferase rimJ YP_977145.1 1142101 D 410289 CDS YP_977146.1 121636923 4695905 1142873..1143949 1 NC_008769.1 Differs from Rv0996 by 1aa, D92G, and from Mb1023 by 1aa, D92G; hypothetical protein 1143949 4695905 BCG_1051 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977146.1 1142873 D 410289 CDS YP_977147.1 121636924 4697081 1144123..1144353 1 NC_008769.1 hypothetical protein 1144353 4697081 BCG_1052 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977147.1 1144123 D 410289 CDS YP_977148.1 121636925 4696956 1144350..1144601 1 NC_008769.1 hypothetical protein 1144601 4696956 BCG_1053 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977148.1 1144350 D 410289 CDS YP_977149.1 121636926 4696937 1144782..1145213 1 NC_008769.1 hypothetical protein 1145213 4696937 BCG_1054 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977149.1 1144782 D 410289 CDS YP_977150.1 121636927 4695670 1145237..1146238 1 NC_008769.1 hypothetical protein 1146238 4695670 BCG_1055 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977150.1 1145237 D 410289 CDS YP_977151.1 121636928 4696088 1146256..1147014 1 NC_008769.1 hypothetical protein 1147014 4696088 BCG_1056 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977151.1 1146256 D 410289 CDS YP_977152.1 121636929 4696684 complement(1147020..1147637) 1 NC_008769.1 hypothetical protein 1147637 4696684 BCG_1057c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977152.1 1147020 R 410289 CDS YP_977153.1 121636930 4697140 1147674..1148882 1 NC_008769.1 catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 1148882 arcA 4697140 arcA Mycobacterium bovis BCG str. Pasteur 1173P2 arginine deiminase YP_977153.1 1147674 D 410289 CDS YP_977154.1 121636931 4695564 complement(1148917..1150428) 1 NC_008769.1 Differs from Rv1002c by 1aa, L115V; hypothetical protein 1150428 4695564 BCG_1059c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977154.1 1148917 R 410289 CDS YP_977155.1 121636932 4696619 1150511..1151368 1 NC_008769.1 hypothetical protein 1151368 4696619 BCG_1060 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977155.1 1150511 D 410289 CDS YP_977156.1 121636933 4697035 complement(1151378..1152637) 1 NC_008769.1 hypothetical protein 1152637 4697035 BCG_1061c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977156.1 1151378 R 410289 CDS YP_977157.1 121636934 4696043 complement(1152711..1154147) 1 NC_008769.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; aminodeoxychorismate synthase component I 1154147 pabB 4696043 pabB Mycobacterium bovis BCG str. Pasteur 1173P2 aminodeoxychorismate synthase component I YP_977157.1 1152711 R 410289 CDS YP_977158.1 121636935 4695406 1154203..1155906 1 NC_008769.1 Differs from Rv1006 by 1aa, S535P, and from Mb1033 by 1aa, N25S; hypothetical protein 1155906 4695406 BCG_1063 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977158.1 1154203 D 410289 CDS YP_977159.1 121636936 4695974 complement(1155933..1157492) 1 NC_008769.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 1157492 metS 4695974 metS Mycobacterium bovis BCG str. Pasteur 1173P2 methionyl-tRNA synthetase YP_977159.1 1155933 R 410289 CDS YP_977160.1 121636937 4699105 1157578..1158372 1 NC_008769.1 Differs from Rv1008 by 1aa, N186T; deoxyribonuclease TatD (YjjV protein) 1158372 tatD 4699105 tatD Mycobacterium bovis BCG str. Pasteur 1173P2 deoxyribonuclease TatD (YjjV protein) YP_977160.1 1157578 D 410289 CDS YP_977161.1 121636938 4697792 1158580..1159668 1 NC_008769.1 Differs from Rv1009 by 2aa, E282G, V357A; resuscitation-promoting factor rpfB 1159668 rpfB 4697792 rpfB Mycobacterium bovis BCG str. Pasteur 1173P2 resuscitation-promoting factor rpfB YP_977161.1 1158580 D 410289 CDS YP_977162.1 121636939 4697713 1159641..1160594 1 NC_008769.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1160594 ksgA 4697713 ksgA Mycobacterium bovis BCG str. Pasteur 1173P2 dimethyladenosine transferase YP_977162.1 1159641 D 410289 CDS YP_977163.1 121636940 4696457 1160680..1161600 1 NC_008769.1 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1161600 ispE 4696457 ispE Mycobacterium bovis BCG str. Pasteur 1173P2 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_977163.1 1160680 D 410289 CDS YP_977164.1 121636941 4697436 1161597..1161911 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1012 exists as a single gene. In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a different NH2 terminus. Differs from Rv1012 by 1aa, N65S; hypothetical protein 1161911 4697436 BCG_1069 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977164.1 1161597 D 410289 CDS YP_977165.1 121636942 4695878 1162115..1163749 1 NC_008769.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1163749 pks16 4695878 pks16 Mycobacterium bovis BCG str. Pasteur 1173P2 long-chain-fatty-acid--CoA ligase YP_977165.1 1162115 D 410289 CDS YP_977166.1 121636943 4698458 complement(1163823..1164398) 1 NC_008769.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1164398 pth 4698458 pth Mycobacterium bovis BCG str. Pasteur 1173P2 peptidyl-tRNA hydrolase YP_977166.1 1163823 R 410289 CDS YP_977167.1 121636944 4697317 complement(1164411..1165058) 1 NC_008769.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 1165058 rplY 4697317 rplY Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L25 YP_977167.1 1164411 R 410289 CDS YP_977168.1 121636945 4697627 complement(1165192..1165950) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a 5 bp deletion (cacgc-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; lipoprotein lpqT 1165950 lpqT 4697627 lpqT Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqT YP_977168.1 1165192 R 410289 CDS YP_977169.1 121636946 4696681 complement(1165986..1166966) 1 NC_008769.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1166966 prsA 4696681 prsA Mycobacterium bovis BCG str. Pasteur 1173P2 ribose-phosphate pyrophosphokinase YP_977169.1 1165986 R 410289 CDS YP_977170.1 121636947 4697278 complement(1167058..1168545) 1 NC_008769.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 1168545 glmU 4697278 glmU Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_977170.1 1167058 R 410289 CDS YP_977171.1 121636948 4696852 1168800..1169393 1 NC_008769.1 TetR family transcriptional regulator 1169393 4696852 BCG_1076 Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_977171.1 1168800 D 410289 CDS YP_977172.1 121636949 4696286 1169452..1173156 1 NC_008769.1 transcription-repair coupling factor mfd 1173156 mfd 4696286 mfd Mycobacterium bovis BCG str. Pasteur 1173P2 transcription-repair coupling factor mfd YP_977172.1 1169452 D 410289 CDS YP_977173.1 121636950 4698999 1173156..1174133 1 NC_008769.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era; nucleoside triphosphate pyrophosphohydrolase 1174133 4698999 BCG_1078 Mycobacterium bovis BCG str. Pasteur 1173P2 nucleoside triphosphate pyrophosphohydrolase YP_977173.1 1173156 D 410289 CDS YP_977174.1 121636951 4696992 1174221..1174952 1 NC_008769.1 Differs from Rv1022 by 1aa, P33T; lipoprotein lpqU 1174952 lpqU 4696992 lpqU Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqU YP_977174.1 1174221 D 410289 CDS YP_977175.1 121636952 4696682 1175049..1176338 1 NC_008769.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1176338 eno 4696682 eno Mycobacterium bovis BCG str. Pasteur 1173P2 phosphopyruvate hydratase YP_977175.1 1175049 D 410289 CDS YP_977176.1 121636953 4697043 1176343..1177029 1 NC_008769.1 hypothetical protein 1177029 4697043 BCG_1081 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977176.1 1176343 D 410289 CDS YP_977177.1 121636954 4697461 1177046..1177513 1 NC_008769.1 hypothetical protein 1177513 4697461 BCG_1082 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977177.1 1177046 D 410289 CDS YP_977178.1 121636955 4696016 1177504..1178463 1 NC_008769.1 hypothetical protein 1178463 4696016 BCG_1083 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977178.1 1177504 D 410289 CDS YP_977179.1 121636956 4696961 complement(1178912..1179592) 1 NC_008769.1 transcriptional regulatory protein kdpE 1179592 kdpE 4696961 kdpE Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein kdpE YP_977179.1 1178912 R 410289 CDS YP_977180.1 121636957 4695428 complement(1179589..1182171) 1 NC_008769.1 Differs from Rv1028c by 3aa, S83P, D295G, S368P, and from Mb1056c by 1aa, S83P; sensor protein kdpD 1182171 kdpD 4695428 kdpD Mycobacterium bovis BCG str. Pasteur 1173P2 sensor protein kdpD YP_977180.1 1179589 R 410289 CDS YP_977181.1 121636958 4695427 1182405..1182497 1 NC_008769.1 membrane protein kdpF 1182497 kdpF 4695427 kdpF Mycobacterium bovis BCG str. Pasteur 1173P2 membrane protein kdpF YP_977181.1 1182405 D 410289 CDS YP_977182.1 121636959 4696453 1182497..1184212 1 NC_008769.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 1184212 kdpA 4696453 kdpA Mycobacterium bovis BCG str. Pasteur 1173P2 potassium-transporting ATPase subunit A YP_977182.1 1182497 D 410289 CDS YP_977183.1 121636960 4695424 1184209..1186338 1 NC_008769.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 1186338 kdpB 4695424 kdpB Mycobacterium bovis BCG str. Pasteur 1173P2 potassium-transporting ATPase subunit B YP_977183.1 1184209 D 410289 CDS YP_977184.1 121636961 4695425 1186338..1186907 1 NC_008769.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 1186907 kdpC 4695425 kdpC Mycobacterium bovis BCG str. Pasteur 1173P2 potassium-transporting ATPase subunit C YP_977184.1 1186338 D 410289 CDS YP_977185.1 121636962 4695426 complement(1186911..1188440) 1 NC_008769.1 two component sensor histidine kinase trcS 1188440 trcS 4695426 trcS Mycobacterium bovis BCG str. Pasteur 1173P2 two component sensor histidine kinase trcS YP_977185.1 1186911 R 410289 CDS YP_977186.1 121636963 4696820 complement(1188448..1189221) 1 NC_008769.1 two component transcriptional regulator trcR 1189221 trcR 4696820 trcR Mycobacterium bovis BCG str. Pasteur 1173P2 two component transcriptional regulator trcR YP_977186.1 1188448 R 410289 CDS YP_977187.1 121636964 4696819 complement(1189403..1189792) 1 NC_008769.1 transposase 1189792 4696819 BCG_1092c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_977187.1 1189403 R 410289 CDS YP_977188.1 121636965 4696970 complement(1189860..1190546) 1 NC_008769.1 transposase 1190546 4696970 BCG_1093c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_977188.1 1189860 R 410289 CDS YP_977189.1 121636966 4696948 complement(1190580..1190918) 1 NC_008769.1 IS1560 transposase 1190918 4696948 BCG_1094c Mycobacterium bovis BCG str. Pasteur 1173P2 IS1560 transposase YP_977189.1 1190580 R 410289 CDS YP_977190.1 121636967 4695988 complement(1191029..1191313) 1 NC_008769.1 Differs from Rv1037c by 1aa, L20Q; ESAT-6 like protein 1 1191313 esxI 4695988 esxI Mycobacterium bovis BCG str. Pasteur 1173P2 ESAT-6 like protein 1 YP_977190.1 1191029 R 410289 CDS YP_977191.1 121636968 4696861 complement(1191340..1191636) 1 NC_008769.1 ESAT-6 like protein 2 1191636 esxJ 4696861 esxJ Mycobacterium bovis BCG str. Pasteur 1173P2 ESAT-6 like protein 2 YP_977191.1 1191340 R 410289 CDS YP_977192.1 121636969 4696776 complement(1191782..1192957) 1 NC_008769.1 Differs from Rv1039c and Mb1068c by 1aa, K175N; PPE family protein 1192957 PPE15 4696776 PPE15 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977192.1 1191782 R 410289 CDS YP_977193.1 121636970 4697238 complement(1193034..1193861) 1 NC_008769.1 PE family protein 1193861 PE8 4697238 PE8 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_977193.1 1193034 R 410289 CDS YP_977194.1 121636971 4696964 complement(1195577..1195984) 1 NC_008769.1 Differs from Rv1042c by 1aa, E129G; IS like-2 transposase 1195984 4696964 BCG_1100c Mycobacterium bovis BCG str. Pasteur 1173P2 IS like-2 transposase YP_977194.1 1195577 R 410289 CDS YP_977195.1 121636972 4695517 complement(1196267..1197292) 1 NC_008769.1 Differs from Rv1043c by 1aa, T99A, and from Mb1072c by 1aa, G263C; hypothetical protein 1197292 4695517 BCG_1101c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977195.1 1196267 R 410289 CDS YP_977196.1 121636973 4696076 1197539..1198162 1 NC_008769.1 hypothetical protein 1198162 4696076 BCG_1102 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977196.1 1197539 D 410289 CDS YP_977197.1 121636974 4696177 1198159..1199040 1 NC_008769.1 Differs from Mb1074 by 1aa, W104G; hypothetical protein 1199040 4696177 BCG_1103 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977197.1 1198159 D 410289 CDS YP_977198.1 121636975 4695976 complement(1199122..1199715) 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a 1bp insertion, compared to Mycobacterium tuberculosis strains H37Rv, leads to different C-terminus; hypothetical protein 1199715 4695976 BCG_1104c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977198.1 1199122 R 410289 CDS YP_977199.1 121636976 4696038 1199910..1201157 1 NC_008769.1 IS1081 transposase 1201157 4696038 BCG_1105 Mycobacterium bovis BCG str. Pasteur 1173P2 IS1081 transposase YP_977199.1 1199910 D 410289 CDS YP_977200.1 121636977 4696073 complement(1201525..1202640) 1 NC_008769.1 Differs from Rv1048c and Mb1077c by 2aa, A37D, T173A; hypothetical protein 1202640 4696073 BCG_1106c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977200.1 1201525 R 410289 CDS YP_977201.1 121636978 4696013 1202873..1203319 1 NC_008769.1 transcriptional repressor protein 1203319 4696013 BCG_1107 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional repressor protein YP_977201.1 1202873 D 410289 CDS YP_977202.1 121636979 4696028 1203367..1204272 1 NC_008769.1 oxidoreductase 1204272 4696028 BCG_1108 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_977202.1 1203367 D 410289 CDS YP_977203.1 121636980 4696519 complement(1204431..1205186) 1 NC_008769.1 hypothetical protein 1205186 4696519 BCG_1109c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977203.1 1204431 R 410289 CDS YP_977204.1 121636981 4696520 1206209..1206598 1 NC_008769.1 hypothetical protein 1206598 4696520 BCG_1110 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977204.1 1206209 D 410289 CDS YP_977205.1 121636982 4695989 complement(1206497..1206772) 1 NC_008769.1 hypothetical protein 1206772 4695989 BCG_1111c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977205.1 1206497 R 410289 CDS YP_977206.1 121636983 4696036 1207414..1207728 1 NC_008769.1 integrase 1207728 4696036 BCG_1112 Mycobacterium bovis BCG str. Pasteur 1173P2 integrase YP_977206.1 1207414 D 410289 CDS YP_977207.1 121636984 4696668 1207725..1207859 1 NC_008769.1 integrase 1207859 4696668 BCG_1113 Mycobacterium bovis BCG str. Pasteur 1173P2 integrase YP_977207.1 1207725 D 410289 CDS YP_977208.1 121636985 4696752 1208114..1208878 1 NC_008769.1 hypothetical protein 1208878 4696752 BCG_1114 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977208.1 1208114 D 410289 CDS YP_977209.1 121636986 4696150 1209882..1211063 1 NC_008769.1 hypothetical protein 1211063 4696150 BCG_1115 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977209.1 1209882 D 410289 CDS YP_977210.1 121636987 4696045 1211170..1212801 1 NC_008769.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1212801 fadD14 4696045 fadD14 Mycobacterium bovis BCG str. Pasteur 1173P2 long-chain-fatty-acid--CoA ligase YP_977210.1 1211170 D 410289 CDS YP_977211.1 121636988 4699325 1212877..1213941 1 NC_008769.1 hypothetical protein 1213941 4699325 BCG_1117 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977211.1 1212877 D 410289 CDS YP_977212.1 121636989 4696943 1213994..1214467 1 NC_008769.1 hypothetical protein 1214467 4696943 BCG_1118 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977212.1 1213994 D 410289 CDS YP_977213.1 121636990 4696041 1214501..1215364 1 NC_008769.1 hypothetical protein 1215364 4696041 BCG_1119 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977213.1 1214501 D 410289 CDS YP_977214.1 121636991 4695998 1215369..1216226 1 NC_008769.1 hypothetical protein 1216226 4695998 BCG_1120 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977214.1 1215369 D 410289 CDS YP_977215.1 121636992 4695543 complement(1216227..1217309) 1 NC_008769.1 hypothetical protein 1217309 4695543 BCG_1121c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977215.1 1216227 R 410289 CDS YP_977216.1 121636993 4696969 complement(1217390..1217809) 1 NC_008769.1 lipoprotein lpqV 1217809 lpqV 4696969 lpqV Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqV YP_977216.1 1217390 R 410289 CDS YP_977217.1 121636994 4697728 1217921..1218487 1 NC_008769.1 hypothetical protein 1218487 4697728 BCG_1123 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977217.1 1217921 D 410289 CDS YP_977218.1 121636995 4696912 1218484..1218879 1 NC_008769.1 hypothetical protein 1218879 4696912 BCG_1124 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977218.1 1218484 D 410289 CDS YP_977219.1 121636996 4696220 complement(1218907..1220922) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, 2 deletions each of 3 bp (ccg-* and cgc-*) and a 18 bp insertion leads to a longer product compared to their homolog in Mycobacterium tuberculosis strain H37Rv (671 aa versus 667 aa); PE-PGRS family protein 1220922 PE_PGRS19 4696220 PE_PGRS19 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977219.1 1218907 R 410289 CDS YP_977220.1 121636997 4697721 complement(1221255..1223447) 1 NC_008769.1 In Mycobacterium bovis, insertions of 717 bp and 192 bp, and a 9 bp (tccgctgcc-*) deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (763 aa versus 463 aa). In Mycobacterium bovis BCG Pasteur a deletion of 99 bp leads to a smaller product compared to the homolog in Mycobacterium bovis (730 aa versus 763 aa); PE-PGRS family protein 1223447 PE_PGRS20 4697721 PE_PGRS20 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977220.1 1221255 R 410289 CDS YP_977221.1 121636998 4697723 complement(1223809..1225572) 1 NC_008769.1 Differs from Rv1069c and from Mb1098c by 1aa L481P; hypothetical protein 1225572 4697723 BCG_1127c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977221.1 1223809 R 410289 CDS YP_977222.1 121636999 4696909 complement(1225569..1226342) 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1226342 echA8 4696909 echA8 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_977222.1 1225569 R 410289 CDS YP_977223.1 121637000 4697680 complement(1226354..1227391) 1 NC_008769.1 catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; 3-hydroxyisobutyryl-CoA hydrolase 1227391 echA9 4697680 echA9 Mycobacterium bovis BCG str. Pasteur 1173P2 3-hydroxyisobutyryl-CoA hydrolase YP_977223.1 1226354 R 410289 CDS YP_977224.1 121637001 4696676 1227578..1228414 1 NC_008769.1 hypothetical protein 1228414 4696676 BCG_1130 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977224.1 1227578 D 410289 CDS YP_977225.1 121637002 4696933 1228530..1229381 1 NC_008769.1 hypothetical protein 1229381 4696933 BCG_1131 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977225.1 1228530 D 410289 CDS YP_977226.1 121637003 4696979 complement(1229455..1230672) 1 NC_008769.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 1230672 fadA3 4696979 fadA3 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-CoA acetyltransferase YP_977226.1 1229455 R 410289 CDS YP_977227.1 121637004 4697588 complement(1230725..1231669) 1 NC_008769.1 hypothetical protein 1231669 4697588 BCG_1133c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977227.1 1230725 R 410289 CDS YP_977228.1 121637005 4697610 1232066..1232959 1 NC_008769.1 lipase lipU 1232959 lipU 4697610 lipU Mycobacterium bovis BCG str. Pasteur 1173P2 lipase lipU YP_977228.1 1232066 D 410289 CDS YP_977229.1 121637006 4696906 1233016..1234410 1 NC_008769.1 cystathionine beta-synthase 1234410 cbs 4696906 cbs Mycobacterium bovis BCG str. Pasteur 1173P2 cystathionine beta-synthase YP_977229.1 1233016 D 410289 CDS YP_977230.1 121637007 4695837 1234612..1235334 1 NC_008769.1 Differs from Rv1078 by 1aa T171I; hypothetical protein 1235334 pra 4695837 pra Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977230.1 1234612 D 410289 CDS YP_977231.1 121637008 4696490 1235366..1236532 1 NC_008769.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 1236532 metB 4696490 metB Mycobacterium bovis BCG str. Pasteur 1173P2 cystathionine gamma-synthase YP_977231.1 1235366 D 410289 CDS YP_977232.1 121637009 4698209 complement(1236603..1237097) 1 NC_008769.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1237097 greA 4698209 greA Mycobacterium bovis BCG str. Pasteur 1173P2 transcription elongation factor GreA YP_977232.1 1236603 R 410289 CDS YP_977233.1 121637010 4698393 complement(1237283..1237717) 1 NC_008769.1 hypothetical protein 1237717 4698393 BCG_1139c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977233.1 1237283 R 410289 CDS YP_977234.1 121637011 4696926 1237819..1238685 1 NC_008769.1 Mycothiol conjugate amidase Mca 1238685 mca 4696926 mca Mycobacterium bovis BCG str. Pasteur 1173P2 Mycothiol conjugate amidase Mca YP_977234.1 1237819 D 410289 CDS YP_977235.1 121637012 4695350 1238682..1238948 1 NC_008769.1 hypothetical protein 1238948 4695350 BCG_1141 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977235.1 1238682 D 410289 CDS YP_977236.1 121637013 4695864 1238935..1240956 1 NC_008769.1 hypothetical protein 1240956 4695864 BCG_1142 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977236.1 1238935 D 410289 CDS YP_977237.1 121637014 4696317 complement(1241055..1241783) 1 NC_008769.1 hemolysin-like protein 1241783 4696317 BCG_1143c Mycobacterium bovis BCG str. Pasteur 1173P2 hemolysin-like protein YP_977237.1 1241055 R 410289 CDS YP_977238.1 121637015 4697154 1241894..1242682 1 NC_008769.1 Short (C15) chain Z-isoprenyl diphosphate synthase 1242682 4697154 BCG_1144 Mycobacterium bovis BCG str. Pasteur 1173P2 Short (C15) chain Z-isoprenyl diphosphate synthase YP_977238.1 1241894 D 410289 CDS YP_977239.1 121637016 4697531 1242859..1245288 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, insertions of 144 bp and 3bp, and deletion of 42 bp, lead to a longer product compared to the homolog in Mycobacterium bovis (809 aa versus 774 aa). In Mycobacterium bovis, insertions of 3 bp (*-gcg) and 45 bp, and deletions of 18 bp and 9 bp (ggtggggcc-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (774 aa versus 767 aa); PE-PGRS family protein 1245288 PE_PGRS21 4697531 PE_PGRS21 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977239.1 1242859 D 410289 CDS YP_977240.1 121637017 4696632 1245465..1245785 1 NC_008769.1 hypothetical protein 1245785 4696632 BCG_1146 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977240.1 1245465 D 410289 CDS YP_977241.1 121637018 4697811 1245938..1246372 1 NC_008769.1 PE family protein 1246372 PE9 4697811 PE9 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_977241.1 1245938 D 410289 CDS YP_977242.1 121637019 4696117 1246251..1246556 1 NC_008769.1 Differs from Rv1089 and Mb1118 by 1 aa N84T; PE family protein 1246556 PE10 4696117 PE10 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_977242.1 1246251 D 410289 CDS YP_977243.1 121637020 4696008 1246942..1247046 1 NC_008769.1 cellulase celA2a 1247046 celA2a 4696008 celA2a Mycobacterium bovis BCG str. Pasteur 1173P2 cellulase celA2a YP_977243.1 1246942 D 410289 CDS YP_977244.1 121637021 4697535 1247024..1247479 1 NC_008769.1 cellulase celA2b 1247479 celA2b 4697535 celA2b Mycobacterium bovis BCG str. Pasteur 1173P2 cellulase celA2b YP_977244.1 1247024 D 410289 CDS YP_977245.1 121637022 4697538 1247894..1250446 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 9 bp deletion (ccggcggca-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (850 aa versus 853 aa); PE-PGRS family protein 1250446 PE_PGRS22 4697538 PE_PGRS22 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977245.1 1247894 D 410289 CDS YP_977246.1 121637023 4696633 complement(1250664..1251602) 1 NC_008769.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 1251602 coaA 4696633 coaA Mycobacterium bovis BCG str. Pasteur 1173P2 pantothenate kinase YP_977246.1 1250664 R 410289 CDS YP_977247.1 121637024 4698605 1251990..1253270 1 NC_008769.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 1253270 glyA 4698605 glyA Mycobacterium bovis BCG str. Pasteur 1173P2 serine hydroxymethyltransferase YP_977247.1 1251990 D 410289 CDS YP_977248.1 121637025 4697846 1253375..1254202 1 NC_008769.1 acyl-ACP desaturase 1254202 desA2 4697846 desA2 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-ACP desaturase YP_977248.1 1253375 D 410289 CDS YP_977249.1 121637026 4696846 1254413..1255714 1 NC_008769.1 phoH-like protein phoH2 1255714 phoH2 4696846 phoH2 Mycobacterium bovis BCG str. Pasteur 1173P2 phoH-like protein phoH2 YP_977249.1 1254413 D 410289 CDS YP_977250.1 121637027 4697586 1255801..1256676 1 NC_008769.1 Differs from Rv1096 by 1aa, S272P; glycosyl hydrolase 1256676 4697586 BCG_1156 Mycobacterium bovis BCG str. Pasteur 1173P2 glycosyl hydrolase YP_977250.1 1255801 D 410289 CDS YP_977251.1 121637028 4696746 complement(1256679..1257560) 1 NC_008769.1 Differs from Rv1097c by 1aa, L23P; membrane glycine and proline rich protein 1257560 4696746 BCG_1157c Mycobacterium bovis BCG str. Pasteur 1173P2 membrane glycine and proline rich protein YP_977251.1 1256679 R 410289 CDS YP_977252.1 121637029 4696665 complement(1257557..1258981) 1 NC_008769.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1258981 fumC 4696665 fumC Mycobacterium bovis BCG str. Pasteur 1173P2 fumarate hydratase YP_977252.1 1257557 R 410289 CDS YP_977253.1 121637030 4695503 complement(1259012..1259998) 1 NC_008769.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 1259998 glpX 4695503 glpX Mycobacterium bovis BCG str. Pasteur 1173P2 fructose 1,6-bisphosphatase II YP_977253.1 1259012 R 410289 CDS YP_977254.1 121637031 4696837 1260099..1260800 1 NC_008769.1 Differs from Rv1100 and Mb1130 by 1aa, P21T; hypothetical protein 1260800 4696837 BCG_1160 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977254.1 1260099 D 410289 CDS YP_977255.1 121637032 4696152 complement(1260807..1261835) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (t-*) leads to a shorter product with a different amino part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Mb1131c by 1 aa, E315D; hypothetical protein 1261835 4696152 BCG_1161c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977255.1 1260807 R 410289 CDS YP_977256.1 121637033 4696033 complement(1262075..1262386) 1 NC_008769.1 Differs from Rv1102c by 1aa, I65T; hypothetical protein 1262386 4696033 BCG_1162c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977256.1 1262075 R 410289 CDS YP_977257.1 121637034 4696941 complement(1262386..1262706) 1 NC_008769.1 hypothetical protein 1262706 4696941 BCG_1163c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977257.1 1262386 R 410289 CDS YP_977258.1 121637035 4696973 1262716..1263405 1 NC_008769.1 para-nitrobenzyl esterase 1263405 4696973 BCG_1164 Mycobacterium bovis BCG str. Pasteur 1173P2 para-nitrobenzyl esterase YP_977258.1 1262716 D 410289 CDS YP_977259.1 121637036 4696711 1263726..1264241 1 NC_008769.1 para-nitrobenzyl esterase 1264241 4696711 BCG_1165 Mycobacterium bovis BCG str. Pasteur 1173P2 para-nitrobenzyl esterase YP_977259.1 1263726 D 410289 CDS YP_977260.1 121637037 4695475 complement(1264259..1265371) 1 NC_008769.1 cholesterol dehydrogenase 1265371 4695475 BCG_1166c Mycobacterium bovis BCG str. Pasteur 1173P2 cholesterol dehydrogenase YP_977260.1 1264259 R 410289 CDS YP_977261.1 121637038 4696032 complement(1265381..1265638) 1 NC_008769.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 1265638 xseB 4696032 xseB Mycobacterium bovis BCG str. Pasteur 1173P2 exodeoxyribonuclease VII small subunit YP_977261.1 1265381 R 410289 CDS YP_977262.1 121637039 4697556 complement(1265628..1266875) 1 NC_008769.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 1266875 xseA 4697556 xseA Mycobacterium bovis BCG str. Pasteur 1173P2 exodeoxyribonuclease VII large subunit YP_977262.1 1265628 R 410289 CDS YP_977263.1 121637040 4697555 complement(1266872..1267510) 1 NC_008769.1 Differs from Rv1109c and Mb1139c by 1aa, T147A; hypothetical protein 1267510 4697555 BCG_1169c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977263.1 1266872 R 410289 CDS YP_977264.1 121637041 4696975 1267600..1268607 1 NC_008769.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1268607 ispH 4696975 ispH Mycobacterium bovis BCG str. Pasteur 1173P2 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_977264.1 1267600 D 410289 CDS YP_977265.1 121637042 4698306 complement(1268624..1269607) 1 NC_008769.1 hypothetical protein 1269607 4698306 BCG_1171c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977265.1 1268624 R 410289 CDS YP_977266.1 121637043 4696967 1269670..1270743 1 NC_008769.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1270743 4696967 BCG_1172 Mycobacterium bovis BCG str. Pasteur 1173P2 GTP-dependent nucleic acid-binding protein EngD YP_977266.1 1269670 D 410289 CDS YP_977267.1 121637044 4695571 1270831..1271028 1 NC_008769.1 hypothetical protein 1271028 4695571 BCG_1173 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977267.1 1270831 D 410289 CDS YP_977268.1 121637045 4696613 1271025..1271399 1 NC_008769.1 hypothetical protein 1271399 4696613 BCG_1174 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977268.1 1271025 D 410289 CDS YP_977269.1 121637046 4696287 1271602..1272300 1 NC_008769.1 Differs from Rv1115 by 1aa, P19S; hypothetical protein 1272300 4696287 BCG_1175 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977269.1 1271602 D 410289 CDS YP_977270.1 121637047 4695378 1272418..1272603 1 NC_008769.1 hypothetical protein 1272603 4695378 BCG_1176 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977270.1 1272418 D 410289 CDS YP_977271.1 121637048 4697367 complement(1272530..1272805) 1 NC_008769.1 hypothetical protein 1272805 4697367 BCG_1177c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977271.1 1272530 R 410289 CDS YP_977272.1 121637049 4697495 1273048..1273371 1 NC_008769.1 hypothetical protein 1273371 4697495 BCG_1178 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977272.1 1273048 D 410289 CDS YP_977273.1 121637050 4697402 complement(1273386..1274246) 1 NC_008769.1 hypothetical protein 1274246 4697402 BCG_1179c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977273.1 1273386 R 410289 CDS YP_977274.1 121637051 4697498 complement(1274279..1274428) 1 NC_008769.1 hypothetical protein 1274428 4697498 BCG_1180c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977274.1 1274279 R 410289 CDS YP_977275.1 121637052 4697323 complement(1274425..1274919) 1 NC_008769.1 Differs from Mb1151c by 1aa, G53A; hypothetical protein 1274919 4697323 BCG_1181c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977275.1 1274425 R 410289 CDS YP_977276.1 121637053 4696808 1275122..1276522 1 NC_008769.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1276522 zwf1 4696808 zwf1 Mycobacterium bovis BCG str. Pasteur 1173P2 glucose-6-phosphate 1-dehydrogenase YP_977276.1 1275122 D 410289 CDS YP_977277.1 121637054 4695516 1276544..1277566 1 NC_008769.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; 6-phosphogluconate dehydrogenase 1277566 gnd2 4695516 gnd2 Mycobacterium bovis BCG str. Pasteur 1173P2 6-phosphogluconate dehydrogenase YP_977277.1 1276544 D 410289 CDS YP_977278.1 121637055 4697623 complement(1277559..1278467) 1 NC_008769.1 peroxidase bpoB 1278467 bpoB 4697623 bpoB Mycobacterium bovis BCG str. Pasteur 1173P2 peroxidase bpoB YP_977278.1 1277559 R 410289 CDS YP_977279.1 121637056 4696158 1278542..1279492 1 NC_008769.1 epoxide hydrolase ephC 1279492 ephC 4696158 ephC Mycobacterium bovis BCG str. Pasteur 1173P2 epoxide hydrolase ephC YP_977279.1 1278542 D 410289 CDS YP_977280.1 121637057 4698527 1279497..1280741 1 NC_008769.1 Differs from Rv1125 by 1aa, G101S; hypothetical protein 1280741 4698527 BCG_1186 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977280.1 1279497 D 410289 CDS YP_977281.1 121637058 4696720 complement(1280745..1281350) 1 NC_008769.1 hypothetical protein 1281350 4696720 BCG_1187c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977281.1 1280745 R 410289 CDS YP_977282.1 121637059 4696384 complement(1281347..1282819) 1 NC_008769.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 1282819 ppdK 4696384 ppdK Mycobacterium bovis BCG str. Pasteur 1173P2 pyruvate phosphate dikinase YP_977282.1 1281347 R 410289 CDS YP_977283.1 121637060 4696159 complement(1283032..1284387) 1 NC_008769.1 Differs from Rv1128c by 1aa, G270E; hypothetical protein 1284387 4696159 BCG_1189c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977283.1 1283032 R 410289 CDS YP_977284.1 121637061 4696232 complement(1284489..1285949) 1 NC_008769.1 transcriptional regulator protein 1285949 4696232 BCG_1190c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulator protein YP_977284.1 1284489 R 410289 CDS YP_977285.1 121637062 4696949 1285970..1287550 1 NC_008769.1 Differs from Rv1130 by 2aa, G3D, L10F; hypothetical protein 1287550 4696949 BCG_1191 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977285.1 1285970 D 410289 CDS YP_977286.1 121637063 4695471 1287547..1288728 1 NC_008769.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; citrate synthase 1288728 gltA1 4695471 gltA1 Mycobacterium bovis BCG str. Pasteur 1173P2 citrate synthase YP_977286.1 1287547 D 410289 CDS YP_977287.1 121637064 4696569 1288740..1290470 1 NC_008769.1 Differs from Mb1163 by 1aa, T176M; hypothetical protein 1290470 4696569 BCG_1193 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977287.1 1288740 D 410289 CDS YP_977288.1 121637065 4697809 complement(1290482..1292761) 1 NC_008769.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 1292761 metE 4697809 metE Mycobacterium bovis BCG str. Pasteur 1173P2 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase YP_977288.1 1290482 R 410289 CDS YP_977289.1 121637066 4698211 1293337..1293573 1 NC_008769.1 hypothetical protein 1293573 4698211 BCG_1195 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977289.1 1293337 D 410289 CDS YP_977290.1 121637067 4695995 complement(1293687..1295543) 1 NC_008769.1 PPE family protein 1295543 PPE16 4695995 PPE16 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977290.1 1293687 R 410289 CDS YP_977291.1 121637068 4697239 1295729..1295971 1 NC_008769.1 acetyl-CoA acetyltransferase 1295971 4697239 BCG_1197 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-CoA acetyltransferase YP_977291.1 1295729 D 410289 CDS YP_977292.1 121637069 4695856 1296021..1296362 1 NC_008769.1 enoyl-CoA hydratase 1296362 4695856 BCG_1198 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_977292.1 1296021 D 410289 CDS YP_977293.1 121637070 4695560 complement(1296502..1296870) 1 NC_008769.1 hypothetical protein 1296870 4695560 BCG_1199c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977293.1 1296502 R 410289 CDS YP_977294.1 121637071 4695731 complement(1296887..1297903) 1 NC_008769.1 oxidoreductase 1297903 4695731 BCG_1200c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_977294.1 1296887 R 410289 CDS YP_977295.1 121637072 4696236 complement(1297900..1298400) 1 NC_008769.1 hypothetical protein 1298400 4696236 BCG_1201c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977295.1 1297900 R 410289 CDS YP_977296.1 121637073 4696591 1298762..1299610 1 NC_008769.1 integral membrane protein 1299610 4696591 BCG_1202 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_977296.1 1298762 D 410289 CDS YP_977297.1 121637074 4697765 complement(1299618..1300424) 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1300424 echA11 4697765 echA11 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_977297.1 1299618 R 410289 CDS YP_977298.1 121637075 4698548 complement(1300567..1301373) 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1301373 echA10 4698548 echA10 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_977298.1 1300567 R 410289 CDS YP_977299.1 121637076 4698163 1301477..1302559 1 NC_008769.1 alpha-methylacyl-CoA racemase mcr 1302559 mcr 4698163 mcr Mycobacterium bovis BCG str. Pasteur 1173P2 alpha-methylacyl-CoA racemase mcr YP_977299.1 1301477 D 410289 CDS YP_977300.1 121637077 4697639 1302571..1303323 1 NC_008769.1 short-chain type dehydrogenase/reductase 1303323 4697639 BCG_1206 Mycobacterium bovis BCG str. Pasteur 1173P2 short-chain type dehydrogenase/reductase YP_977300.1 1302571 D 410289 CDS YP_977301.1 121637078 4697576 1303838..1306183 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1145 and Rv1146 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-a) at H37Rv position 1273250-1273251 leads to a single product; transmembrane transport protein mmpL13 1306183 mmpL13 4697576 mmpL13 Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane transport protein mmpL13 YP_977301.1 1303838 D 410289 CDS YP_977302.1 121637079 4697543 1306316..1306966 1 NC_008769.1 hypothetical protein 1306966 4697543 BCG_1208 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977302.1 1306316 D 410289 CDS YP_977303.1 121637080 4697287 complement(1307716..1309164) 1 NC_008769.1 Differs from Rv1148c and Mb1179c by 1aa, N354H; hypothetical protein 1309164 4697287 BCG_1209c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977303.1 1307716 R 410289 CDS YP_977304.1 121637081 4696207 1309309..1309716 1 NC_008769.1 transposase 1309716 4696207 BCG_1210 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_977304.1 1309309 D 410289 CDS YP_977305.1 121637082 4696307 complement(1310320..1311033) 1 NC_008769.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1311033 4696307 BCG_1212c Mycobacterium bovis BCG str. Pasteur 1173P2 NAD-dependent deacetylase YP_977305.1 1310320 R 410289 CDS YP_977306.1 121637083 4698065 1311071..1311436 1 NC_008769.1 transcriptional regulatory protein 1311436 4698065 BCG_1213 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977306.1 1311071 D 410289 CDS YP_977307.1 121637084 4698345 complement(1311414..1312262) 1 NC_008769.1 Differs from Rv1153c by 2aa, T36A, G53D; O-methyltransferase omt 1312262 omt 4698345 omt Mycobacterium bovis BCG str. Pasteur 1173P2 O-methyltransferase omt YP_977307.1 1311414 R 410289 CDS YP_977308.1 121637085 4696327 complement(1312259..1312900) 1 NC_008769.1 Differs from Rv1154c by 1aa, A123T; hypothetical protein 1312900 4696327 BCG_1215c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977308.1 1312259 R 410289 CDS YP_977309.1 121637086 4697456 1312845..1313288 1 NC_008769.1 Differs from Rv1155 by 1aa, P115S; hypothetical protein 1313288 4697456 BCG_1216 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977309.1 1312845 D 410289 CDS YP_977310.1 121637087 4697017 1313722..1314309 1 NC_008769.1 hypothetical protein 1314309 4697017 BCG_1217 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977310.1 1313722 D 410289 CDS YP_977311.1 121637088 4696306 complement(1314472..1315515) 1 NC_008769.1 Is 24 codons shorter than Rv1157c and Mb1188c due to 72bp deletion at position equivalent to H37Rv, 1283458-1283529. After codon 214; hypothetical protein 1315515 4696306 BCG_1218c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977311.1 1314472 R 410289 CDS YP_977312.1 121637089 4695931 complement(1315523..1316206) 1 NC_008769.1 hypothetical protein 1316206 4695931 BCG_1219c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977312.1 1315523 R 410289 CDS YP_977313.1 121637090 4696470 1316336..1317631 1 NC_008769.1 involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis; mannosyltransferase 1317631 pimE 4696470 pimE Mycobacterium bovis BCG str. Pasteur 1173P2 mannosyltransferase YP_977313.1 1316336 D 410289 CDS YP_977314.1 121637091 4697181 complement(1317628..1317912) 1 NC_008769.1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction; pterin-4-alpha-carbinolamine dehydratase 1317912 phhB 4697181 phhB Mycobacterium bovis BCG str. Pasteur 1173P2 pterin-4-alpha-carbinolamine dehydratase YP_977314.1 1317628 R 410289 CDS YP_977315.1 121637092 4695685 1317939..1318364 1 NC_008769.1 mutator protein mutT2 1318364 mutT2 4695685 mutT2 Mycobacterium bovis BCG str. Pasteur 1173P2 mutator protein mutT2 YP_977315.1 1317939 D 410289 CDS YP_977316.1 121637093 4697974 1318672..1322370 1 NC_008769.1 Differs from Rv1161 by 2aa, L458V, G821D; respiratory nitrate reductase (alpha chain) narG 1322370 narG 4697974 narG Mycobacterium bovis BCG str. Pasteur 1173P2 respiratory nitrate reductase (alpha chain) narG YP_977316.1 1318672 D 410289 CDS YP_977317.1 121637094 4697114 1322409..1324085 1 NC_008769.1 respiratory nitrate reductase subunit beta narH 1324085 narH 4697114 narH Mycobacterium bovis BCG str. Pasteur 1173P2 respiratory nitrate reductase subunit beta narH YP_977317.1 1322409 D 410289 CDS YP_977318.1 121637095 4697115 1324142..1324747 1 NC_008769.1 Differs from Rv1163 and Mb1195 by 1aa, L106P; respiratory nitrate reductase (delta chain) narJ 1324747 narJ 4697115 narJ Mycobacterium bovis BCG str. Pasteur 1173P2 respiratory nitrate reductase (delta chain) narJ YP_977318.1 1324142 D 410289 CDS YP_977319.1 121637096 4697117 1324750..1325490 1 NC_008769.1 Differs from Rv1164 by 1aa, V200A; respiratory nitrate reductase (gamma chain) narI 1325490 narI 4697117 narI Mycobacterium bovis BCG str. Pasteur 1173P2 respiratory nitrate reductase (gamma chain) narI YP_977319.1 1324750 D 410289 CDS YP_977320.1 121637097 4697116 1325512..1327398 1 NC_008769.1 GTP-binding translation elongation factor typA 1327398 typA 4697116 typA Mycobacterium bovis BCG str. Pasteur 1173P2 GTP-binding translation elongation factor typA YP_977320.1 1325512 D 410289 CDS YP_977321.1 121637098 4696862 1327496..1329403 1 NC_008769.1 lipoprotein lpqW 1329403 lpqW 4696862 lpqW Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqW YP_977321.1 1327496 D 410289 CDS YP_977322.1 121637099 4697729 complement(1329431..1330036) 1 NC_008769.1 transcriptional regulatory protein 1330036 4697729 BCG_1229c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977322.1 1329431 R 410289 CDS YP_977323.1 121637100 4697066 complement(1330607..1331149) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PPE17 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and in Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits PPE17 into 2 parts, PPE17a and PPE17b; PPE family protein 1331149 PPE17a 4697066 PPE17a Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977323.1 1330607 R 410289 CDS YP_977324.1 121637101 4697240 complement(1331167..1331469) 1 NC_008769.1 PE family protein 1331469 PE11 4697240 PE11 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_977324.1 1331167 R 410289 CDS YP_977325.1 121637102 4696009 1331649..1332560 1 NC_008769.1 N-Acetyl-1-D-myo-Inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase mshB 1332560 mshB 4696009 mshB Mycobacterium bovis BCG str. Pasteur 1173P2 N-Acetyl-1-D-myo-Inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase mshB YP_977325.1 1331649 D 410289 CDS YP_977326.1 121637103 4697735 1332652..1333092 1 NC_008769.1 hypothetical protein 1333092 4697735 BCG_1234 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977326.1 1332652 D 410289 CDS YP_977327.1 121637104 4697052 complement(1333100..1334026) 1 NC_008769.1 Differs from Rv1172c by 1aa, H133Q; PE family protein 1334026 PE12 4697052 PE12 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_977327.1 1333100 R 410289 CDS YP_977328.1 121637105 4696010 1334276..1336846 1 NC_008769.1 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; FO synthase 1336846 fbiC 4696010 fbiC Mycobacterium bovis BCG str. Pasteur 1173P2 FO synthase YP_977328.1 1334276 D 410289 CDS YP_977329.1 121637106 4696563 complement(1336952..1337284) 1 NC_008769.1 hypothetical protein 1337284 4696563 BCG_1237c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977329.1 1336952 R 410289 CDS YP_977330.1 121637107 4696713 complement(1337485..1339509) 1 NC_008769.1 Differs from Rv1175c by 3aa, N90T, S210T, S649I; NADPH dependent 2,4-dienoyl-CoA reductase fadH 1339509 fadH 4696713 fadH Mycobacterium bovis BCG str. Pasteur 1173P2 NADPH dependent 2,4-dienoyl-CoA reductase fadH YP_977330.1 1337485 R 410289 CDS YP_977331.1 121637108 4695681 complement(1339506..1340075) 1 NC_008769.1 hypothetical protein 1340075 4695681 BCG_1239c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977331.1 1339506 R 410289 CDS YP_977332.1 121637109 4697460 1340288..1340614 1 NC_008769.1 ferredoxin fdxC 1340614 fdxC 4697460 fdxC Mycobacterium bovis BCG str. Pasteur 1173P2 ferredoxin fdxC YP_977332.1 1340288 D 410289 CDS YP_977333.1 121637110 4695361 1340647..1341735 1 NC_008769.1 catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; N-succinyldiaminopimelate aminotransferase 1341735 4695361 BCG_1241 Mycobacterium bovis BCG str. Pasteur 1173P2 N-succinyldiaminopimelate aminotransferase YP_977333.1 1340647 D 410289 CDS YP_977334.1 121637111 4697152 complement(1341763..1344582) 1 NC_008769.1 hypothetical protein 1344582 4697152 BCG_1242c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977334.1 1341763 R 410289 CDS YP_977335.1 121637112 4696765 1345009..1351266 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1180 and Rv1181 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transversion (a-c) leads to a single product (similar to other organisms). Differs from Rv1181 by 2aa, A1068D, P1423A; polyketide beta-ketoacyl synthase pks3 1351266 pks3 4696765 pks3 Mycobacterium bovis BCG str. Pasteur 1173P2 polyketide beta-ketoacyl synthase pks3 YP_977335.1 1345009 D 410289 CDS YP_977336.1 121637113 4698461 1351319..1352737 1 NC_008769.1 polyketide synthase associated protein papA3 1352737 papA3 4698461 papA3 Mycobacterium bovis BCG str. Pasteur 1173P2 polyketide synthase associated protein papA3 YP_977336.1 1351319 D 410289 CDS YP_977337.1 121637114 4698056 1352804..1355812 1 NC_008769.1 transmembrane transport protein mmpL10 1355812 mmpL10 4698056 mmpL10 Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane transport protein mmpL10 YP_977337.1 1352804 D 410289 CDS YP_977338.1 121637115 4697540 complement(1355816..1356895) 1 NC_008769.1 hypothetical protein 1356895 4697540 BCG_1246c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977338.1 1355816 R 410289 CDS YP_977339.1 121637116 4696740 complement(1357060..1358796) 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1358796 fadD21 4696740 fadD21 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_977339.1 1357060 R 410289 CDS YP_977340.1 121637117 4696733 complement(1358973..1360589) 1 NC_008769.1 Differs from Rv1186c by 1aa, A207P; hypothetical protein 1360589 4696733 BCG_1248c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977340.1 1358973 R 410289 CDS YP_977341.1 121637118 4697146 1360674..1362305 1 NC_008769.1 pyrroline-5-carboxylate dehydrogenase rocA 1362305 rocA 4697146 rocA Mycobacterium bovis BCG str. Pasteur 1173P2 pyrroline-5-carboxylate dehydrogenase rocA YP_977341.1 1360674 D 410289 CDS YP_977342.1 121637119 4696319 1362305..1363294 1 NC_008769.1 proline dehydrogenase 1363294 4696319 BCG_1250 Mycobacterium bovis BCG str. Pasteur 1173P2 proline dehydrogenase YP_977342.1 1362305 D 410289 CDS YP_977343.1 121637120 4697225 1363376..1364581 1 NC_008769.1 member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigI 1364581 sigI 4697225 sigI Mycobacterium bovis BCG str. Pasteur 1173P2 RNA polymerase sigma factor SigI YP_977343.1 1363376 D 410289 CDS YP_977344.1 121637121 4695357 1364663..1365490 1 NC_008769.1 hypothetical protein 1365490 4695357 BCG_1252 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977344.1 1364663 D 410289 CDS YP_977345.1 121637122 4697325 1365530..1366951 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1366951 fadD36 4697325 fadD36 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_977345.1 1365530 D 410289 CDS YP_977346.1 121637123 4697148 complement(1366984..1368249) 1 NC_008769.1 hypothetical protein 1368249 4697148 BCG_1254c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977346.1 1366984 R 410289 CDS YP_977347.1 121637124 4695845 1368725..1369024 1 NC_008769.1 PE family protein 1369024 PE13 4695845 PE13 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_977347.1 1368725 D 410289 CDS YP_977348.1 121637125 4696011 1369071..1370243 1 NC_008769.1 In Mycobacterium bovis, a 14 bp to 11 bp substitution leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (390 aa versus 391 aa). Differs extensively from orthologs Mb1228 and Rv1196 due to numerous substitutions and transitions. Region from aa 210 - 260 shows most difference; PPE family protein 1370243 PPE18 4696011 PPE18 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977348.1 1369071 D 410289 CDS YP_977349.1 121637126 4697067 1370378..1370674 1 NC_008769.1 Differs from Mb1229 by 1aa, A58T; ESAT-6 like protein 3 1370674 esxK 4697067 esxK Mycobacterium bovis BCG str. Pasteur 1173P2 ESAT-6 like protein 3 YP_977349.1 1370378 D 410289 CDS YP_977350.1 121637127 4697763 1370725..1371009 1 NC_008769.1 Differs from Rv1198 by 1aa, D12A; ESAT-6 like protein 4 1371009 esxL 4697763 esxL Mycobacterium bovis BCG str. Pasteur 1173P2 ESAT-6 like protein 4 YP_977350.1 1370725 D 410289 CDS YP_977351.1 121637128 4697568 complement(1371077..1372324) 1 NC_008769.1 Differs from Rv1199c and Mb1231c by 1aa, G90D; transposase 1372324 4697568 BCG_1259c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_977351.1 1371077 R 410289 CDS YP_977352.1 121637129 4697241 1372661..1373938 1 NC_008769.1 integral membrane transport protein 1373938 4697241 BCG_1260 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane transport protein YP_977352.1 1372661 D 410289 CDS YP_977353.1 121637130 4696391 complement(1373935..1374888) 1 NC_008769.1 transferase 1374888 4696391 BCG_1261c Mycobacterium bovis BCG str. Pasteur 1173P2 transferase YP_977353.1 1373935 R 410289 CDS YP_977354.1 121637131 4697688 1374979..1376043 1 NC_008769.1 catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; succinyl-diaminopimelate desuccinylase 1376043 dapE 4697688 dapE Mycobacterium bovis BCG str. Pasteur 1173P2 succinyl-diaminopimelate desuccinylase YP_977354.1 1374979 D 410289 CDS YP_977355.1 121637132 4697363 complement(1376040..1376624) 1 NC_008769.1 hypothetical protein 1376624 4697363 BCG_1263c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977355.1 1376040 R 410289 CDS YP_977356.1 121637133 4695538 complement(1376655..1378343) 1 NC_008769.1 hypothetical protein 1378343 4695538 BCG_1264c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977356.1 1376655 R 410289 CDS YP_977357.1 121637134 4695724 1378438..1379001 1 NC_008769.1 hypothetical protein 1379001 4695724 BCG_1265 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977357.1 1378438 D 410289 CDS YP_977358.1 121637135 4695490 1379051..1380844 1 NC_008769.1 activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization; long-chain-acyl-CoA synthetase 1380844 fadD6 4695490 fadD6 Mycobacterium bovis BCG str. Pasteur 1173P2 long-chain-acyl-CoA synthetase YP_977358.1 1379051 D 410289 CDS YP_977359.1 121637136 4696273 1380910..1381866 1 NC_008769.1 dihydropteroate synthase 2 folP2 1381866 folP2 4696273 folP2 Mycobacterium bovis BCG str. Pasteur 1173P2 dihydropteroate synthase 2 folP2 YP_977359.1 1380910 D 410289 CDS YP_977360.1 121637137 4695629 1381863..1382837 1 NC_008769.1 glucosyl-3-phosphoglycerate synthase 1382837 4695629 BCG_1268 Mycobacterium bovis BCG str. Pasteur 1173P2 glucosyl-3-phosphoglycerate synthase YP_977360.1 1381863 D 410289 CDS YP_977361.1 121637138 4695588 1382876..1383244 1 NC_008769.1 hypothetical protein 1383244 4695588 BCG_1269 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977361.1 1382876 D 410289 CDS YP_977362.1 121637139 4697851 1383241..1383855 1 NC_008769.1 DNA-3-methyladenine glycosylase i tagA 1383855 tagA 4697851 tagA Mycobacterium bovis BCG str. Pasteur 1173P2 DNA-3-methyladenine glycosylase i tagA YP_977362.1 1383241 D 410289 CDS YP_977363.1 121637140 4696337 1383963..1384190 1 NC_008769.1 hypothetical protein 1384190 4696337 BCG_1271 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977363.1 1383963 D 410289 CDS YP_977364.1 121637141 4697324 complement(1384218..1385381) 1 NC_008769.1 Differs from Rv1212c by 2aa, I105V, W340L and from Mb1244c by 1aa, W340L; glycosyl transferase family protein 1385381 4697324 BCG_1272c Mycobacterium bovis BCG str. Pasteur 1173P2 glycosyl transferase family protein YP_977364.1 1384218 R 410289 CDS YP_977365.1 121637142 4696300 1385556..1386770 1 NC_008769.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1386770 glgC 4696300 glgC Mycobacterium bovis BCG str. Pasteur 1173P2 glucose-1-phosphate adenylyltransferase YP_977365.1 1385556 D 410289 CDS YP_977366.1 121637143 4696642 complement(1387013..1387345) 1 NC_008769.1 In Mycobacterium bovis BCG and Mycobacterium tuberculosis strain H37Rv, PE14 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 5 bp deletion (cttgt-*) leads to a diffferent COOH terminus; PE family protein 1387345 PE14 4696642 PE14 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_977366.1 1387013 R 410289 CDS YP_977367.1 121637144 4696012 complement(1387479..1389164) 1 NC_008769.1 Differs from Rv1215c by 1aa, S169A; hypothetical protein 1389164 4696012 BCG_1275c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977367.1 1387479 R 410289 CDS YP_977368.1 121637145 4698313 complement(1389192..1389866) 1 NC_008769.1 integral membrane protein 1389866 4698313 BCG_1276c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_977368.1 1389192 R 410289 CDS YP_977369.1 121637146 4696804 complement(1389875..1391521) 1 NC_008769.1 Differs from Mb1249c by 1aa, A143T; tetronasin-transport integral membrane protein ABC transporter 1391521 4696804 BCG_1277c Mycobacterium bovis BCG str. Pasteur 1173P2 tetronasin-transport integral membrane protein ABC transporter YP_977369.1 1389875 R 410289 CDS YP_977370.1 121637147 4695470 complement(1391518..1392453) 1 NC_008769.1 Differs from Rv1218c by 1aa, R243Q; tetronasin-transport atp-binding protein ABC transporter 1392453 4695470 BCG_1278c Mycobacterium bovis BCG str. Pasteur 1173P2 tetronasin-transport atp-binding protein ABC transporter YP_977370.1 1391518 R 410289 CDS YP_977371.1 121637148 4697874 complement(1392443..1393081) 1 NC_008769.1 Differs from Rv1219c and Mb1251c by 1aa, C113W; transcriptional regulatory protein 1393081 4697874 BCG_1279c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977371.1 1392443 R 410289 CDS YP_977372.1 121637149 4698811 complement(1393223..1393870) 1 NC_008769.1 methyltransferase 1393870 4698811 BCG_1280c Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase YP_977372.1 1393223 R 410289 CDS YP_977373.1 121637150 4698250 1394133..1394906 1 NC_008769.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence; RNA polymerase sigma factor SigE 1394906 sigE 4698250 sigE Mycobacterium bovis BCG str. Pasteur 1173P2 RNA polymerase sigma factor SigE YP_977373.1 1394133 D 410289 CDS YP_977374.1 121637151 4695817 1395064..1395528 1 NC_008769.1 hypothetical protein 1395528 4695817 BCG_1282 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977374.1 1395064 D 410289 CDS YP_977375.1 121637152 4698600 1395597..1397183 1 NC_008769.1 Differs from Rv1223 by 2aa, L288F, N445S; serine protease htrA 1397183 htrA 4698600 htrA Mycobacterium bovis BCG str. Pasteur 1173P2 serine protease htrA YP_977375.1 1395597 D 410289 CDS YP_977376.1 121637153 4696305 1397185..1397580 1 NC_008769.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 1397580 tatB 4696305 tatB Mycobacterium bovis BCG str. Pasteur 1173P2 sec-independent translocase YP_977376.1 1397185 D 410289 CDS YP_977377.1 121637154 4697790 complement(1397613..1398443) 1 NC_008769.1 hypothetical protein 1398443 4697790 BCG_1285c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977377.1 1397613 R 410289 CDS YP_977378.1 121637155 4698653 complement(1398554..1400017) 1 NC_008769.1 Differs from Rv1226c by 1aa, A450V; hypothetical protein 1400017 4698653 BCG_1286c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977378.1 1398554 R 410289 CDS YP_977379.1 121637156 4697143 complement(1400014..1400547) 1 NC_008769.1 hypothetical protein 1400547 4697143 BCG_1287c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977379.1 1400014 R 410289 CDS YP_977380.1 121637157 4699294 1400642..1401199 1 NC_008769.1 lipoprotein lpqX 1401199 lpqX 4699294 lpqX Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqX YP_977380.1 1400642 D 410289 CDS YP_977381.1 121637158 4697730 complement(1401499..1402671) 1 NC_008769.1 MRP-related protein mrp 1402671 mrp 4697730 mrp Mycobacterium bovis BCG str. Pasteur 1173P2 MRP-related protein mrp YP_977381.1 1401499 R 410289 CDS YP_977382.1 121637159 4698096 complement(1402684..1403919) 1 NC_008769.1 Differs from Rv1230c by 2aa, G45S, P97S; hypothetical protein 1403919 4698096 BCG_1290c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977382.1 1402684 R 410289 CDS YP_977383.1 121637160 4697015 complement(1404044..1404586) 1 NC_008769.1 hypothetical protein 1404586 4697015 BCG_1291c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977383.1 1404044 R 410289 CDS YP_977384.1 121637161 4696605 complement(1404583..1405890) 1 NC_008769.1 Differs from Rv1232c by 1aa, G149C; hypothetical protein 1405890 4696605 BCG_1292c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977384.1 1404583 R 410289 CDS YP_977385.1 121637162 4696709 complement(1405952..1406548) 1 NC_008769.1 Differs from Rv1233c by 1aa, D46N; hypothetical protein 1406548 4696709 BCG_1293c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977385.1 1405952 R 410289 CDS YP_977386.1 121637163 4698030 1406698..1407225 1 NC_008769.1 hypothetical protein 1407225 4698030 BCG_1294 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977386.1 1406698 D 410289 CDS YP_977387.1 121637164 4696574 1407246..1408652 1 NC_008769.1 sugar-binding lipoprotein lpqY 1408652 lpqY 4696574 lpqY Mycobacterium bovis BCG str. Pasteur 1173P2 sugar-binding lipoprotein lpqY YP_977387.1 1407246 D 410289 CDS YP_977388.1 121637165 4697731 1408649..1409572 1 NC_008769.1 sugar-transport integral membrane protein ABC transporter sugA 1409572 sugA 4697731 sugA Mycobacterium bovis BCG str. Pasteur 1173P2 sugar-transport integral membrane protein ABC transporter sugA YP_977388.1 1408649 D 410289 CDS YP_977389.1 121637166 4696768 1409577..1410401 1 NC_008769.1 sugar-transport integral membrane protein ABC transporter sugB 1410401 sugB 4696768 sugB Mycobacterium bovis BCG str. Pasteur 1173P2 sugar-transport integral membrane protein ABC transporter sugB YP_977389.1 1409577 D 410289 CDS YP_977390.1 121637167 4696769 1410406..1411587 1 NC_008769.1 sugar-transport ATP-binding protein ABC transporter sugC 1411587 sugC 4696769 sugC Mycobacterium bovis BCG str. Pasteur 1173P2 sugar-transport ATP-binding protein ABC transporter sugC YP_977390.1 1410406 D 410289 CDS YP_977391.1 121637168 4696770 complement(1411664..1412764) 1 NC_008769.1 Differs from Rv1239c by 1aa, E139K, and from Mb1271c by 1aa, H195R; magnesium and cobalt transport transmembrane protein corA 1412764 corA 4696770 corA Mycobacterium bovis BCG str. Pasteur 1173P2 magnesium and cobalt transport transmembrane protein corA YP_977391.1 1411664 R 410289 CDS YP_977392.1 121637169 4697907 1412935..1413924 1 NC_008769.1 catalyzes the oxidation of malate to oxaloacetate; malate dehydrogenase 1413924 mdh 4697907 mdh Mycobacterium bovis BCG str. Pasteur 1173P2 malate dehydrogenase YP_977392.1 1412935 D 410289 CDS YP_977393.1 121637170 4696703 1414000..1414260 1 NC_008769.1 hypothetical protein 1414260 4696703 BCG_1301 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977393.1 1414000 D 410289 CDS YP_977394.1 121637171 4695843 1414257..1414688 1 NC_008769.1 hypothetical protein 1414688 4695843 BCG_1302 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977394.1 1414257 D 410289 CDS YP_977395.1 121637172 4695699 complement(1414711..1416399) 1 NC_008769.1 PE-PGRS family protein 1416399 PE_PGRS23 4695699 PE_PGRS23 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977395.1 1414711 R 410289 CDS YP_977396.1 121637173 4696634 1416579..1417439 1 NC_008769.1 Differs from Rv1244 by 1aa, K242Q; lipoprotein lpqZ 1417439 lpqZ 4696634 lpqZ Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqZ YP_977396.1 1416579 D 410289 CDS YP_977397.1 121637174 4697732 complement(1417520..1418350) 1 NC_008769.1 short-chain type dehydrogenase/reductase 1418350 4697732 BCG_1305c Mycobacterium bovis BCG str. Pasteur 1173P2 short-chain type dehydrogenase/reductase YP_977397.1 1417520 R 410289 CDS YP_977398.1 121637175 4696354 complement(1418407..1418700) 1 NC_008769.1 hypothetical protein 1418700 4696354 BCG_1306c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977398.1 1418407 R 410289 CDS YP_977399.1 121637176 4695557 complement(1418697..1418966) 1 NC_008769.1 hypothetical protein 1418966 4695557 BCG_1307c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977399.1 1418697 R 410289 CDS YP_977400.1 121637177 4697169 complement(1419079..1422723) 1 NC_008769.1 kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; alpha-ketoglutarate decarboxylase 1422723 kgd 4697169 kgd Mycobacterium bovis BCG str. Pasteur 1173P2 alpha-ketoglutarate decarboxylase YP_977400.1 1419079 R 410289 CDS YP_977401.1 121637178 4696455 complement(1422916..1423704) 1 NC_008769.1 Differs from Rv1249c by 1aa, T95A; hypothetical protein 1423704 4696455 BCG_1309c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977401.1 1422916 R 410289 CDS YP_977402.1 121637179 4695776 1423901..1425640 1 NC_008769.1 Differs from Rv1250 by 1aa, G278R; drug-transport integral membrane protein 1425640 4695776 BCG_1310 Mycobacterium bovis BCG str. Pasteur 1173P2 drug-transport integral membrane protein YP_977402.1 1423901 D 410289 CDS YP_977403.1 121637180 4695932 complement(1425543..1428962) 1 NC_008769.1 hypothetical protein 1428962 4695932 BCG_1311c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977403.1 1425543 R 410289 CDS YP_977404.1 121637181 4697150 complement(1429018..1429626) 1 NC_008769.1 lipoprotein lprE 1429626 lprE 4697150 lprE Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lprE YP_977404.1 1429018 R 410289 CDS YP_977405.1 121637182 4695400 1429692..1431383 1 NC_008769.1 Differs from Rv1253 by 1aa, V143M; cold-shock dead-box protein a deaD 1431383 deaD 4695400 deaD Mycobacterium bovis BCG str. Pasteur 1173P2 cold-shock dead-box protein a deaD YP_977405.1 1429692 D 410289 CDS YP_977406.1 121637183 4696539 1431380..1432531 1 NC_008769.1 acyltransferase 1432531 4696539 BCG_1314 Mycobacterium bovis BCG str. Pasteur 1173P2 acyltransferase YP_977406.1 1431380 D 410289 CDS YP_977407.1 121637184 4699303 complement(1432500..1432799) 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 3007 bp deletion (RD13) leads to the fusion of Rv1257c and Rv1255c, and the deletion of Rv1256c, compared to Mycobacterium tuberculosis strain H37Rv; hypothetical protein 1432799 4699303 BCG_1315c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977407.1 1432500 R 410289 CDS YP_977408.1 121637185 4697701 complement(1432796..1434055) 1 NC_008769.1 integral membrane transport protein 1434055 4697701 BCG_1316c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane transport protein YP_977408.1 1432796 R 410289 CDS YP_977409.1 121637186 4697243 1434054..1434953 1 NC_008769.1 hypothetical protein 1434953 4697243 BCG_1317 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977409.1 1434054 D 410289 CDS YP_977410.1 121637187 4697949 1434955..1435779 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as a single gene. In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv1260 into 2 parts; oxidoreductase 1435779 4697949 BCG_1318 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_977410.1 1434955 D 410289 CDS YP_977411.1 121637188 4697873 1435764..1436072 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium Bovis, a frameshift due to a single base deletion (g-*) splits Rv1260 into 2 parts; oxidoreductase 1436072 4697873 BCG_1319 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_977411.1 1435764 D 410289 CDS YP_977412.1 121637189 4698116 complement(1436198..1436647) 1 NC_008769.1 hypothetical protein 1436647 4698116 BCG_1320c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977412.1 1436198 R 410289 CDS YP_977413.1 121637190 4699123 complement(1436652..1437086) 1 NC_008769.1 Differs from Rv1262c by 1aa, R104P; HIT family protein 1437086 4699123 BCG_1321c Mycobacterium bovis BCG str. Pasteur 1173P2 HIT family protein YP_977413.1 1436652 R 410289 CDS YP_977414.1 121637191 4699249 1437145..1438533 1 NC_008769.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 1438533 amiB2 4699249 amiB2 Mycobacterium bovis BCG str. Pasteur 1173P2 amidase YP_977414.1 1437145 D 410289 CDS YP_977415.1 121637192 4695489 1438608..1439801 1 NC_008769.1 Differs from Rv1264 by 1aa, C204R; adenylyl cyclase 1439801 4695489 BCG_1323 Mycobacterium bovis BCG str. Pasteur 1173P2 adenylyl cyclase YP_977415.1 1438608 D 410289 CDS YP_977416.1 121637193 4699050 1439974..1440654 1 NC_008769.1 hypothetical protein 1440654 4699050 BCG_1324 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977416.1 1439974 D 410289 CDS YP_977417.1 121637194 4698961 complement(1440674..1442464) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, the pknH gene contains several substitutions, transitions and transversions compared to Mycobacterium tuberculosis strain H37Rv. The most significant difference results from a 127 bp to 24 bp substitution that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (596 aa versus 626 aa). Differs from Mb1297c by 2aa, F374L, I396N; transmembrane serine/threonine-protein kinase H pknH 1442464 pknH 4698961 pknH Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane serine/threonine-protein kinase H pknH YP_977417.1 1440674 R 410289 CDS YP_977418.1 121637195 4697523 complement(1442805..1443971) 1 NC_008769.1 transcriptional regulatory protein embR 1443971 embR 4697523 embR Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein embR YP_977418.1 1442805 R 410289 CDS YP_977419.1 121637196 4696659 complement(1444282..1444980) 1 NC_008769.1 hypothetical protein 1444980 4696659 BCG_1327c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977419.1 1444282 R 410289 CDS YP_977420.1 121637197 4698701 complement(1445203..1445577) 1 NC_008769.1 hypothetical protein 1445577 4698701 BCG_1328c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977420.1 1445203 R 410289 CDS YP_977421.1 121637198 4698743 complement(1445638..1446372) 1 NC_008769.1 Differs from Mb1301c by 1aa, A134T; lipoprotein lprA 1446372 lprA 4698743 lprA Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lprA YP_977421.1 1445638 R 410289 CDS YP_977422.1 121637199 4695396 complement(1446585..1446926) 1 NC_008769.1 hypothetical protein 1446926 4695396 BCG_1330c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977422.1 1446585 R 410289 CDS YP_977423.1 121637200 4698841 complement(1447034..1448929) 1 NC_008769.1 drugs-transport transmembrane ATP-binding protein ABC transporter 1448929 4698841 BCG_1331c Mycobacterium bovis BCG str. Pasteur 1173P2 drugs-transport transmembrane ATP-binding protein ABC transporter YP_977423.1 1447034 R 410289 CDS YP_977424.1 121637201 4696292 complement(1448926..1450674) 1 NC_008769.1 drugs-transport transmembrane ATP-binding protein ABC transporter 1450674 4696292 BCG_1332c Mycobacterium bovis BCG str. Pasteur 1173P2 drugs-transport transmembrane ATP-binding protein ABC transporter YP_977424.1 1448926 R 410289 CDS YP_977425.1 121637202 4695465 1450821..1451378 1 NC_008769.1 Differs from Rv1274 by 1aa, P168L; lipoprotein lprB 1451378 lprB 4695465 lprB Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lprB YP_977425.1 1450821 D 410289 CDS YP_977426.1 121637203 4695397 1451375..1451917 1 NC_008769.1 lipoprotein lprC 1451917 lprC 4695397 lprC Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lprC YP_977426.1 1451375 D 410289 CDS YP_977427.1 121637204 4695398 complement(1452062..1452538) 1 NC_008769.1 Differs from Rv1276c by 1aa, S92T; hypothetical protein 1452538 4695398 BCG_1335c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977427.1 1452062 R 410289 CDS YP_977428.1 121637205 4698432 1452788..1454041 1 NC_008769.1 hypothetical protein 1454041 4698432 BCG_1336 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977428.1 1452788 D 410289 CDS YP_977429.1 121637206 4698847 1454038..1456665 1 NC_008769.1 hypothetical protein 1456665 4698847 BCG_1337 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977429.1 1454038 D 410289 CDS YP_977430.1 121637207 4696661 1456686..1458272 1 NC_008769.1 dehydrogenase FAD flavoprotein GMC oxidoreductase 1458272 4696661 BCG_1338 Mycobacterium bovis BCG str. Pasteur 1173P2 dehydrogenase FAD flavoprotein GMC oxidoreductase YP_977430.1 1456686 D 410289 CDS YP_977431.1 121637208 4696736 complement(1458289..1460064) 1 NC_008769.1 periplasmic oligopeptide-binding lipoprotein oppA 1460064 oppA 4696736 oppA Mycobacterium bovis BCG str. Pasteur 1173P2 periplasmic oligopeptide-binding lipoprotein oppA YP_977431.1 1458289 R 410289 CDS YP_977432.1 121637209 4698681 complement(1460057..1461895) 1 NC_008769.1 oligopeptide-transport ATP-binding protein ABC transporter oppD 1461895 oppD 4698681 oppD Mycobacterium bovis BCG str. Pasteur 1173P2 oligopeptide-transport ATP-binding protein ABC transporter oppD YP_977432.1 1460057 R 410289 CDS YP_977433.1 121637210 4698920 complement(1461892..1462767) 1 NC_008769.1 oligopeptide-transport integral membrane protein ABC transporter oppC 1462767 oppC 4698920 oppC Mycobacterium bovis BCG str. Pasteur 1173P2 oligopeptide-transport integral membrane protein ABC transporter oppC YP_977433.1 1461892 R 410289 CDS YP_977434.1 121637211 4698683 complement(1462764..1463741) 1 NC_008769.1 oligopeptide-transport integral membrane protein ABC transporter oppB 1463741 oppB 4698683 oppB Mycobacterium bovis BCG str. Pasteur 1173P2 oligopeptide-transport integral membrane protein ABC transporter oppB YP_977434.1 1462764 R 410289 CDS YP_977435.1 121637212 4698682 1463948..1464439 1 NC_008769.1 beta-carbonic anhydrase 1464439 canA 4698682 canA Mycobacterium bovis BCG str. Pasteur 1173P2 beta-carbonic anhydrase YP_977435.1 1463948 D 410289 CDS YP_977436.1 121637213 4696696 1464533..1465531 1 NC_008769.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 1465531 cysD 4696696 cysD Mycobacterium bovis BCG str. Pasteur 1173P2 sulfate adenylyltransferase subunit 2 YP_977436.1 1464533 D 410289 CDS YP_977437.1 121637214 4696420 1465531..1467375 1 NC_008769.1 in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis; bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase 1467375 cysN 4696420 cysN Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase YP_977437.1 1465531 D 410289 CDS YP_977438.1 121637215 4695463 1467429..1467914 1 NC_008769.1 hypothetical protein 1467914 4695463 BCG_1346 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977438.1 1467429 D 410289 CDS YP_977439.1 121637216 4698316 1467972..1469189 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a 153 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (405 aa versus 456 aa); hypothetical protein 1469189 4698316 BCG_1347 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977439.1 1467972 D 410289 CDS YP_977440.1 121637217 4697517 1469238..1469870 1 NC_008769.1 hypothetical protein 1469870 4697517 BCG_1348 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977440.1 1469238 D 410289 CDS YP_977441.1 121637218 4696653 complement(1470009..1471574) 1 NC_008769.1 hypothetical protein 1471574 4696653 BCG_1349c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977441.1 1470009 R 410289 CDS YP_977442.1 121637219 4698674 1471585..1471899 1 NC_008769.1 hypothetical protein 1471899 4698674 BCG_1350 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977442.1 1471585 D 410289 CDS YP_977443.1 121637220 4697164 complement(1472026..1472361) 1 NC_008769.1 hypothetical protein 1472361 4697164 BCG_1351c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977443.1 1472026 R 410289 CDS YP_977444.1 121637221 4697859 1472906..1474558 1 NC_008769.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1474558 argS 4697859 argS Mycobacterium bovis BCG str. Pasteur 1173P2 arginyl-tRNA synthetase YP_977444.1 1472906 D 410289 CDS YP_977445.1 121637222 4696626 1474555..1475898 1 NC_008769.1 diaminopimelate decarboxylase lysA 1475898 lysA 4696626 lysA Mycobacterium bovis BCG str. Pasteur 1173P2 diaminopimelate decarboxylase lysA YP_977445.1 1474555 D 410289 CDS YP_977446.1 121637223 4697177 1475902..1477227 1 NC_008769.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1477227 thrA 4697177 thrA Mycobacterium bovis BCG str. Pasteur 1173P2 homoserine dehydrogenase YP_977446.1 1475902 D 410289 CDS YP_977447.1 121637224 4697961 1477224..1478306 1 NC_008769.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1478306 thrC 4697961 thrC Mycobacterium bovis BCG str. Pasteur 1173P2 threonine synthase YP_977447.1 1477224 D 410289 CDS YP_977448.1 121637225 4695909 1478524..1479474 1 NC_008769.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1479474 thrB 4695909 thrB Mycobacterium bovis BCG str. Pasteur 1173P2 homoserine kinase YP_977448.1 1478524 D 410289 CDS YP_977449.1 121637226 4697962 1479731..1481539 1 NC_008769.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 1481539 rho 4697962 rho Mycobacterium bovis BCG str. Pasteur 1173P2 transcription termination factor Rho YP_977449.1 1479731 D 410289 CDS YP_977450.1 121637227 4696887 1481690..1481932 1 NC_008769.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1481932 rpmE 4696887 rpmE Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L31 YP_977450.1 1481690 D 410289 CDS YP_977451.1 121637228 4696785 1482022..1483095 1 NC_008769.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1483095 prfA 4696785 prfA Mycobacterium bovis BCG str. Pasteur 1173P2 peptide chain release factor 1 YP_977451.1 1482022 D 410289 CDS YP_977452.1 121637229 4697852 1483092..1484069 1 NC_008769.1 Differs from Mb1332 by 1aa, G121A, and from Rv1300 by 2aa, G121A, C194R; hemk protein hemK 1484069 hemK 4697852 hemK Mycobacterium bovis BCG str. Pasteur 1173P2 hemk protein hemK YP_977452.1 1483092 D 410289 CDS YP_977453.1 121637230 4698905 1484085..1484738 1 NC_008769.1 Differs from Rv1301 by 1aa, Q196P; hypothetical protein 1484738 4698905 BCG_1361 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977453.1 1484085 D 410289 CDS YP_977454.1 121637231 4699362 1484822..1486036 1 NC_008769.1 Differs from Rv1302 by 1aa, G357V; undecapaprenyl-phosphate alpha-n-acetylglucosaminyltransferase rfe 1486036 rfe 4699362 rfe Mycobacterium bovis BCG str. Pasteur 1173P2 undecapaprenyl-phosphate alpha-n-acetylglucosaminyltransferase rfe YP_977454.1 1484822 D 410289 CDS YP_977455.1 121637232 4696798 1486293..1486778 1 NC_008769.1 hypothetical protein 1486778 4696798 BCG_1363 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977455.1 1486293 D 410289 CDS YP_977456.1 121637233 4697989 1486771..1487523 1 NC_008769.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 1487523 atpB 4697989 atpB Mycobacterium bovis BCG str. Pasteur 1173P2 F0F1 ATP synthase subunit A YP_977456.1 1486771 D 410289 CDS YP_977457.1 121637234 4695587 1487572..1487817 1 NC_008769.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 1487817 atpE 4695587 atpE Mycobacterium bovis BCG str. Pasteur 1173P2 F0F1 ATP synthase subunit C YP_977457.1 1487572 D 410289 CDS YP_977458.1 121637235 4697968 1487848..1488363 1 NC_008769.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 1488363 atpF 4697968 atpF Mycobacterium bovis BCG str. Pasteur 1173P2 F0F1 ATP synthase subunit B YP_977458.1 1487848 D 410289 CDS YP_977459.1 121637236 4695616 1488370..1489710 1 NC_008769.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 1489710 atpH 4695616 atpH Mycobacterium bovis BCG str. Pasteur 1173P2 F0F1 ATP synthase subunit delta YP_977459.1 1488370 D 410289 CDS YP_977460.1 121637237 4696200 1489755..1491404 1 NC_008769.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 1491404 atpA 4696200 atpA Mycobacterium bovis BCG str. Pasteur 1173P2 F0F1 ATP synthase subunit alpha YP_977460.1 1489755 D 410289 CDS YP_977461.1 121637238 4696479 1491411..1492328 1 NC_008769.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 1492328 atpG 4696479 atpG Mycobacterium bovis BCG str. Pasteur 1173P2 F0F1 ATP synthase subunit gamma YP_977461.1 1491411 D 410289 CDS YP_977462.1 121637239 4696344 1492368..1493828 1 NC_008769.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 1493828 atpD 4696344 atpD Mycobacterium bovis BCG str. Pasteur 1173P2 F0F1 ATP synthase subunit beta YP_977462.1 1492368 D 410289 CDS YP_977463.1 121637240 4695832 1493842..1494207 1 NC_008769.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 1494207 atpC 4695832 atpC Mycobacterium bovis BCG str. Pasteur 1173P2 F0F1 ATP synthase subunit epsilon YP_977463.1 1493842 D 410289 CDS YP_977464.1 121637241 4695935 1494215..1494649 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 2 bp deletion (cg-*) at the 3' end leads to a slightly shorter product compared to Mycobacterium tuberculosis strain H37Rv (144 aa versus 147 aa). Also differs from Rv1312 by 1aa, V3A; hypothetical protein 1494649 4695935 BCG_1372 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977464.1 1494215 D 410289 CDS YP_977465.1 121637242 4697520 complement(1494696..1495427) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1313c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG, a frameshift due to a 12 bp to 1 bp substitution (cttgtcgtggcc-t) splits Rv1313c into 2 parts; transposase 1495427 4697520 BCG_1373c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_977465.1 1494696 R 410289 CDS YP_977466.1 121637243 4697513 complement(1495402..1496019) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1313c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG, a frameshift due to a 12 bp to 1 bp substitution (cttgtcgtggcc-t) splits Rv1313c into 2 parts; transposase 1496019 4697513 BCG_1374c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_977466.1 1495402 R 410289 CDS YP_977467.1 121637244 4699335 complement(1496185..1496766) 1 NC_008769.1 hypothetical protein 1496766 4699335 BCG_1375c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977467.1 1496185 R 410289 CDS YP_977468.1 121637245 4697002 1496835..1498091 1 NC_008769.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1498091 murA 4697002 murA Mycobacterium bovis BCG str. Pasteur 1173P2 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_977468.1 1496835 D 410289 CDS YP_977469.1 121637246 4698699 complement(1503648..1504145) 1 NC_008769.1 methylated-DNA--protein-cysteine methyltransferase ogt 1504145 ogt 4698699 ogt Mycobacterium bovis BCG str. Pasteur 1173P2 methylated-DNA--protein-cysteine methyltransferase ogt YP_977469.1 1503648 R 410289 CDS YP_977470.1 121637247 4696325 complement(1504142..1505632) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur and Mycobacterium tuberculosis strain H37Rv, alkA exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a premature stop codon that splits alkA into 2 parts, alkAa and alkAb; ada regulatory protein alkA 1505632 alkA 4696325 alkA Mycobacterium bovis BCG str. Pasteur 1173P2 ada regulatory protein alkA YP_977470.1 1504142 R 410289 CDS YP_977471.1 121637248 4697012 complement(1505713..1507338) 1 NC_008769.1 adenylate cyclase 1507338 4697012 BCG_1379c Mycobacterium bovis BCG str. Pasteur 1173P2 adenylate cyclase YP_977471.1 1505713 R 410289 CDS YP_977472.1 121637249 4698128 complement(1507408..1509015) 1 NC_008769.1 adenylate cyclase 1509015 4698128 BCG_1380c Mycobacterium bovis BCG str. Pasteur 1173P2 adenylate cyclase YP_977472.1 1507408 R 410289 CDS YP_977473.1 121637250 4695618 complement(1509028..1510731) 1 NC_008769.1 Differs from Rv1320c by 1aa, A531T; adenylate cyclase 1510731 4695618 BCG_1381c Mycobacterium bovis BCG str. Pasteur 1173P2 adenylate cyclase YP_977473.1 1509028 R 410289 CDS YP_977474.1 121637251 4697745 1510793..1511473 1 NC_008769.1 Differs from Rv1321 by 1aa, R144S; hypothetical protein 1511473 4697745 BCG_1382 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977474.1 1510793 D 410289 CDS YP_977475.1 121637252 4697188 1511496..1511792 1 NC_008769.1 hypothetical protein 1511792 4697188 BCG_1383 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977475.1 1511496 D 410289 CDS YP_977476.1 121637253 4699125 complement(1511827..1512285) 1 NC_008769.1 hypothetical protein 1512285 4699125 BCG_1384c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977476.1 1511827 R 410289 CDS YP_977477.1 121637254 4695368 1512376..1513545 1 NC_008769.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 1513545 fadA4 4695368 fadA4 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-CoA acetyltransferase YP_977477.1 1512376 D 410289 CDS YP_977478.1 121637255 4695371 1513675..1514589 1 NC_008769.1 thioredoxin 1514589 4695371 BCG_1386 Mycobacterium bovis BCG str. Pasteur 1173P2 thioredoxin YP_977478.1 1513675 D 410289 CDS YP_977479.1 121637256 4697594 complement(1514668..1516479) 1 NC_008769.1 Differs from Rv1325c by 1aa, A320T; PE-PGRS family protein 1516479 PE_PGRS24 4697594 PE_PGRS24 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977479.1 1514668 R 410289 CDS YP_977480.1 121637257 4696635 complement(1516631..1518826) 1 NC_008769.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 1518826 glgB 4696635 glgB Mycobacterium bovis BCG str. Pasteur 1173P2 glycogen branching protein YP_977480.1 1516631 R 410289 CDS YP_977481.1 121637258 4696641 complement(1518834..1520939) 1 NC_008769.1 glucanase glgE 1520939 glgE 4696641 glgE Mycobacterium bovis BCG str. Pasteur 1173P2 glucanase glgE YP_977481.1 1518834 R 410289 CDS YP_977482.1 121637259 4696643 1521078..1523669 1 NC_008769.1 Differs from Rv1328 by 3aa, G532D, F576V, S801A; glycogen phosphorylase glgP 1523669 glgP 4696643 glgP Mycobacterium bovis BCG str. Pasteur 1173P2 glycogen phosphorylase glgP YP_977482.1 1521078 D 410289 CDS YP_977483.1 121637260 4696644 complement(1523709..1525703) 1 NC_008769.1 atp-dependent helicase dinG-like protein 1525703 dinG 4696644 dinG Mycobacterium bovis BCG str. Pasteur 1173P2 atp-dependent helicase dinG-like protein YP_977483.1 1523709 R 410289 CDS YP_977484.1 121637261 4697149 complement(1525727..1527073) 1 NC_008769.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1527073 4697149 BCG_1392c Mycobacterium bovis BCG str. Pasteur 1173P2 nicotinate phosphoribosyltransferase YP_977484.1 1525727 R 410289 CDS YP_977485.1 121637262 4698747 1527175..1527480 1 NC_008769.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 1527480 clpS 4698747 clpS Mycobacterium bovis BCG str. Pasteur 1173P2 ATP-dependent Clp protease adaptor protein ClpS YP_977485.1 1527175 D 410289 CDS YP_977486.1 121637263 4698971 1527440..1528096 1 NC_008769.1 transcriptional regulatory protein 1528096 4698971 BCG_1394 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977486.1 1527440 D 410289 CDS YP_977487.1 121637264 4695385 1528113..1529147 1 NC_008769.1 hydrolase 1529147 4695385 BCG_1395 Mycobacterium bovis BCG str. Pasteur 1173P2 hydrolase YP_977487.1 1528113 D 410289 CDS YP_977488.1 121637265 4695414 1529155..1529595 1 NC_008769.1 hypothetical protein 1529595 4695414 BCG_1396 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977488.1 1529155 D 410289 CDS YP_977489.1 121637266 4697211 1529617..1529898 1 NC_008769.1 antigen cfp10A 1529898 4697211 BCG_1397 Mycobacterium bovis BCG str. Pasteur 1173P2 antigen cfp10A YP_977489.1 1529617 D 410289 CDS YP_977490.1 121637267 4699313 1529908..1530879 1 NC_008769.1 cysteine synthase b cysM 1530879 cysM 4699313 cysM Mycobacterium bovis BCG str. Pasteur 1173P2 cysteine synthase b cysM YP_977490.1 1529908 D 410289 CDS YP_977491.1 121637268 4696745 1530870..1531592 1 NC_008769.1 integral membrane protein 1531592 4696745 BCG_1399 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_977491.1 1530870 D 410289 CDS YP_977492.1 121637269 4698028 1531589..1532404 1 NC_008769.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1532404 murI 4698028 murI Mycobacterium bovis BCG str. Pasteur 1173P2 glutamate racemase YP_977492.1 1531589 D 410289 CDS YP_977493.1 121637270 4698428 1532431..1533252 1 NC_008769.1 hypothetical protein 1533252 4698428 BCG_1401 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977493.1 1532431 D 410289 CDS YP_977494.1 121637271 4699222 1533269..1534048 1 NC_008769.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 1534048 rph 4699222 rph Mycobacterium bovis BCG str. Pasteur 1173P2 ribonuclease PH YP_977494.1 1533269 D 410289 CDS YP_977495.1 121637272 4699112 1534087..1534701 1 NC_008769.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 1534701 4699112 BCG_1403 Mycobacterium bovis BCG str. Pasteur 1173P2 deoxyribonucleotide triphosphate pyrophosphatase YP_977495.1 1534087 D 410289 CDS YP_977496.1 121637273 4698639 complement(1534698..1535060) 1 NC_008769.1 hypothetical protein 1535060 4698639 BCG_1404c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977496.1 1534698 R 410289 CDS YP_977497.1 121637274 4699281 complement(1535057..1535437) 1 NC_008769.1 Differs from Rv1343c by 1aa, A81E; lipoprotein lprD 1535437 lprD 4699281 lprD Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lprD YP_977497.1 1535057 R 410289 CDS YP_977498.1 121637275 4695399 1535482..1535802 1 NC_008769.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1535802 4695399 BCG_1406 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl carrier protein YP_977498.1 1535482 D 410289 CDS YP_977499.1 121637276 4699171 1535795..1537360 1 NC_008769.1 converts medium- to long-chain aliphatic fatty acids into acyl adenylate; involved in mycobactin synthesis; long-chain-fatty-acid--ACP ligase 1537360 fadD33 4699171 fadD33 Mycobacterium bovis BCG str. Pasteur 1173P2 long-chain-fatty-acid--ACP ligase YP_977499.1 1535795 D 410289 CDS YP_977500.1 121637277 4695674 1537360..1538520 1 NC_008769.1 acyl-CoA dehydrogenase fadE14 1538520 fadE14 4695674 fadE14 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE14 YP_977500.1 1537360 D 410289 CDS YP_977501.1 121637278 4697441 complement(1538487..1539119) 1 NC_008769.1 hypothetical protein 1539119 4697441 BCG_1409c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977501.1 1538487 R 410289 CDS YP_977502.1 121637279 4696751 1539561..1542140 1 NC_008769.1 drugs-transport transmembrane ATP-binding protein ABC transporter 1542140 4696751 BCG_1410 Mycobacterium bovis BCG str. Pasteur 1173P2 drugs-transport transmembrane ATP-binding protein ABC transporter YP_977502.1 1539561 D 410289 CDS YP_977503.1 121637280 4699041 1542137..1543876 1 NC_008769.1 drugs-transport transmembrane ATP-binding protein ABC transporter 1543876 4699041 BCG_1411 Mycobacterium bovis BCG str. Pasteur 1173P2 drugs-transport transmembrane ATP-binding protein ABC transporter YP_977503.1 1542137 D 410289 CDS YP_977504.1 121637281 4698541 1544005..1544748 1 NC_008769.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1544748 fabG 4698541 fabG Mycobacterium bovis BCG str. Pasteur 1173P2 3-ketoacyl-ACP reductase YP_977504.1 1544005 D 410289 CDS YP_977505.1 121637282 4697020 1544745..1545074 1 NC_008769.1 hypothetical protein 1545074 4697020 BCG_1413 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977505.1 1544745 D 410289 CDS YP_977506.1 121637283 4697780 1545277..1545648 1 NC_008769.1 hypothetical protein 1545648 4697780 BCG_1414 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977506.1 1545277 D 410289 CDS YP_977507.1 121637284 4698269 complement(1545714..1546499) 1 NC_008769.1 transcriptional regulatory protein 1546499 4698269 BCG_1415c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977507.1 1545714 R 410289 CDS YP_977508.1 121637285 4698124 complement(1546519..1548390) 1 NC_008769.1 hypothetical protein 1548390 4698124 BCG_1416c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977508.1 1546519 R 410289 CDS YP_977509.1 121637286 4698468 complement(1548399..1550546) 1 NC_008769.1 Differs from Rv1355c by 1aa (P81L); hypothetical protein 1550546 moeY 4698468 moeY Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977509.1 1548399 R 410289 CDS YP_977510.1 121637287 4698906 complement(1550543..1551334) 1 NC_008769.1 hypothetical protein 1551334 4698906 BCG_1418c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977510.1 1550543 R 410289 CDS YP_977511.1 121637288 4696144 complement(1551807..1552730) 1 NC_008769.1 Differs from Rv1357c and Mb1392c by 1aa, S276T; hypothetical protein 1552730 4696144 BCG_1419c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977511.1 1551807 R 410289 CDS YP_977512.1 121637289 4698127 1553126..1556605 1 NC_008769.1 Differs from Rv1358 by 1aa A442D, and from Mb1393 by 1aa, G31V; transcriptional regulatory protein 1556605 4698127 BCG_1420 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977512.1 1553126 D 410289 CDS YP_977513.1 121637290 4698526 1556687..1557439 1 NC_008769.1 Differs from Mb1394 by 1aa, G187R; transcriptional regulator 1557439 4698526 BCG_1421 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulator YP_977513.1 1556687 D 410289 CDS YP_977514.1 121637291 4697931 1557862..1558884 1 NC_008769.1 oxidoreductase 1558884 4697931 BCG_1422 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_977514.1 1557862 D 410289 CDS YP_977515.1 121637292 4698467 complement(1558957..1560147) 1 NC_008769.1 Differs from Rv1361c by 3aa, Q30K, V55T, P325Q, and more extensively from Mb1396c due to several substitutions, transitions and transversions between codons 158-260; PPE family protein 1560147 PPE19 4698467 PPE19 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977515.1 1558957 R 410289 CDS YP_977516.1 121637293 4697068 complement(1560462..1561124) 1 NC_008769.1 Differs from Rv1362c by 1aa, G103V; hypothetical protein 1561124 4697068 BCG_1424c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977516.1 1560462 R 410289 CDS YP_977517.1 121637294 4698151 complement(1561121..1561906) 1 NC_008769.1 Difefrs from Mb1398c by 1aa, T155N; hypothetical protein 1561906 4698151 BCG_1425c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977517.1 1561121 R 410289 CDS YP_977518.1 121637295 4695849 complement(1562197..1564158) 1 NC_008769.1 Differs from Rv1364c by 2aa, T236A, E465A; hypothetical protein 1564158 4695849 BCG_1426c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977518.1 1562197 R 410289 CDS YP_977519.1 121637296 4697448 complement(1564297..1564683) 1 NC_008769.1 Differs from Rv1365c by 1aa, K82E; hypothetical protein 1564683 4697448 BCG_1427c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977519.1 1564297 R 410289 CDS YP_977520.1 121637297 4698169 1564904..1565725 1 NC_008769.1 hypothetical protein 1565725 4698169 BCG_1428 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977520.1 1564904 D 410289 CDS YP_977521.1 121637298 4696298 complement(1566026..1567159) 1 NC_008769.1 Differs from Rv1367c by 1aa, V169I; hypothetical protein 1567159 4696298 BCG_1429c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977521.1 1566026 R 410289 CDS YP_977522.1 121637299 4698472 1567534..1568319 1 NC_008769.1 lipoprotein lprF 1568319 lprF 4698472 lprF Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lprF YP_977522.1 1567534 D 410289 CDS YP_977523.1 121637300 4698140 1568515..1569468 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a frameshift due to a single base insertion (*-a) splits Rv1371 into 2 parts, with the latter being the more likely product; hypothetical protein 1569468 4698140 BCG_1431 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977523.1 1568515 D 410289 CDS YP_977524.1 121637301 4698433 1568990..1569985 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-a) splits Rv1371 into 2 parts, with the latter being the more likely product. Differs from both Mb1405 and Rv1371 by 1aa, V210I; hypothetical protein 1569985 4698433 BCG_1432 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977524.1 1568990 D 410289 CDS YP_977525.1 121637302 4698481 1569982..1571163 1 NC_008769.1 Differs from Rv1372 and Mb1406 by 2aa, N75K, A101T; hypothetical protein 1571163 4698481 BCG_1433 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977525.1 1569982 D 410289 CDS YP_977526.1 121637303 4698161 1571169..1572152 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1373 exists as a single gene as is the case in Mycobacterium bovis BCG Pasteur. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits Rv1373 into 2 parts, Mb1407 and Mb1408. Differs from Rv1373 by 2aa, additional P, P155, and L232P; glycolipid sulfotransferase 1572152 4698161 BCG_1434 Mycobacterium bovis BCG str. Pasteur 1173P2 glycolipid sulfotransferase YP_977526.1 1571169 D 410289 CDS YP_977527.1 121637304 4695444 complement(1572232..1572690) 1 NC_008769.1 Differs from Rv1374c by 1aa, A136T; hypothetical protein 1572690 4695444 BCG_1435c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977527.1 1572232 R 410289 CDS YP_977528.1 121637305 4696600 1572992..1574311 1 NC_008769.1 Differs from Rv1375 by 1aa, R86G, and from Mb1410 by 1aa, R322P; hypothetical protein 1574311 4696600 BCG_1436 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977528.1 1572992 D 410289 CDS YP_977529.1 121637306 4695554 1574308..1575801 1 NC_008769.1 Differs from Rv1376 by 1aa, P236R; hypothetical protein 1575801 4695554 BCG_1437 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977529.1 1574308 D 410289 CDS YP_977530.1 121637307 4695539 complement(1575739..1576377) 1 NC_008769.1 transferase 1576377 4695539 BCG_1438c Mycobacterium bovis BCG str. Pasteur 1173P2 transferase YP_977530.1 1575739 R 410289 CDS YP_977531.1 121637308 4697515 complement(1576388..1577815) 1 NC_008769.1 Differs from Rv1378c by 1aa, W37R, and from Mb1413c by 1aa, R9H; hypothetical protein 1577815 4697515 BCG_1439c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977531.1 1576388 R 410289 CDS YP_977532.1 121637309 4698109 1577814..1578395 1 NC_008769.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 1578395 pyrR 4698109 pyrR Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase YP_977532.1 1577814 D 410289 CDS YP_977533.1 121637310 4697788 1578392..1579351 1 NC_008769.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 1579351 pyrB 4697788 pyrB Mycobacterium bovis BCG str. Pasteur 1173P2 aspartate carbamoyltransferase YP_977533.1 1578392 D 410289 CDS YP_977534.1 121637311 4696883 1579348..1580640 1 NC_008769.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1580640 pyrC 4696883 pyrC Mycobacterium bovis BCG str. Pasteur 1173P2 dihydroorotase YP_977534.1 1579348 D 410289 CDS YP_977535.1 121637312 4696884 1580637..1581134 1 NC_008769.1 export or membrane protein 1581134 4696884 BCG_1443 Mycobacterium bovis BCG str. Pasteur 1173P2 export or membrane protein YP_977535.1 1580637 D 410289 CDS YP_977536.1 121637313 4697438 1581131..1582261 1 NC_008769.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1582261 carA 4697438 carA Mycobacterium bovis BCG str. Pasteur 1173P2 carbamoyl phosphate synthase small subunit YP_977536.1 1581131 D 410289 CDS YP_977537.1 121637314 4695811 1582261..1585608 1 NC_008769.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1585608 carB 4695811 carB Mycobacterium bovis BCG str. Pasteur 1173P2 carbamoyl phosphate synthase large subunit YP_977537.1 1582261 D 410289 CDS YP_977538.1 121637315 4695581 1585605..1586429 1 NC_008769.1 type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1586429 pyrF 4695581 pyrF Mycobacterium bovis BCG str. Pasteur 1173P2 orotidine 5'-phosphate decarboxylase YP_977538.1 1585605 D 410289 CDS YP_977539.1 121637316 4697785 1586624..1586932 1 NC_008769.1 PE family protein 1586932 PE15 4697785 PE15 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_977539.1 1586624 D 410289 CDS YP_977540.1 121637317 4699005 1586929..1588548 1 NC_008769.1 Differs from Rv1387 by 1aa, A94V; PPE family protein 1588548 PPE20 4699005 PPE20 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977540.1 1586929 D 410289 CDS YP_977541.1 121637318 4697070 1588854..1589426 1 NC_008769.1 integration host factor mihF 1589426 mihF 4697070 mihF Mycobacterium bovis BCG str. Pasteur 1173P2 integration host factor mihF YP_977541.1 1588854 D 410289 CDS YP_977542.1 121637319 4699003 1589561..1590187 1 NC_008769.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1590187 gmk 4699003 gmk Mycobacterium bovis BCG str. Pasteur 1173P2 guanylate kinase YP_977542.1 1589561 D 410289 CDS YP_977543.1 121637320 4697621 1590253..1590585 1 NC_008769.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1590585 rpoZ 4697621 rpoZ Mycobacterium bovis BCG str. Pasteur 1173P2 DNA-directed RNA polymerase subunit omega YP_977543.1 1590253 D 410289 CDS YP_977544.1 121637321 4696377 1590601..1591857 1 NC_008769.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 1591857 dfp 4696377 dfp Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_977544.1 1590601 D 410289 CDS YP_977545.1 121637322 4699155 1591985..1593196 1 NC_008769.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1593196 metK 4699155 metK Mycobacterium bovis BCG str. Pasteur 1173P2 S-adenosylmethionine synthetase YP_977545.1 1591985 D 410289 CDS YP_977546.1 121637323 4699104 complement(1593269..1594747) 1 NC_008769.1 monoxygenase 1594747 4699104 BCG_1454c Mycobacterium bovis BCG str. Pasteur 1173P2 monoxygenase YP_977546.1 1593269 R 410289 CDS YP_977547.1 121637324 4698454 complement(1594744..1596129) 1 NC_008769.1 Differs from Rv1394c by 1aa, L135R; cytochrome P450 132 cyp132 1596129 cyp132 4698454 cyp132 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome P450 132 cyp132 YP_977547.1 1594744 R 410289 CDS YP_977548.1 121637325 4695410 1596207..1597241 1 NC_008769.1 transcriptional regulatory protein 1597241 4695410 BCG_1456 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977548.1 1596207 D 410289 CDS YP_977549.1 121637326 4695915 complement(1597287..1598645) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a 372 bp deletion leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (452 aa versus 576 aa).Differs from Rv1396c by 2aa, S66R, H300R; PE-PGRS family protein 1598645 PE_PGRS25 4695915 PE_PGRS25 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977549.1 1597287 R 410289 CDS YP_977550.1 121637327 4696636 complement(1598900..1599301) 1 NC_008769.1 Differs from Rv1397c by 1aa, G103D; hypothetical protein 1599301 4696636 BCG_1458c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977550.1 1598900 R 410289 CDS YP_977551.1 121637328 4697834 complement(1599298..1599555) 1 NC_008769.1 hypothetical protein 1599555 4697834 BCG_1459c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977551.1 1599298 R 410289 CDS YP_977552.1 121637329 4698003 complement(1599638..1600597) 1 NC_008769.1 Differs from Rv1399c and Mb1434c by 1aa, A46P; lipase lipH 1600597 lipH 4698003 lipH Mycobacterium bovis BCG str. Pasteur 1173P2 lipase lipH YP_977552.1 1599638 R 410289 CDS YP_977553.1 121637330 4698087 complement(1600622..1601584) 1 NC_008769.1 lipase lipH 1601584 lipI 4698087 lipI Mycobacterium bovis BCG str. Pasteur 1173P2 lipase lipH YP_977553.1 1600622 R 410289 CDS YP_977554.1 121637331 4698088 1601718..1602320 1 NC_008769.1 hypothetical protein 1602320 4698088 BCG_1462 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977554.1 1601718 D 410289 CDS YP_977555.1 121637332 4695896 1602401..1604368 1 NC_008769.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 1604368 priA 4695896 priA Mycobacterium bovis BCG str. Pasteur 1173P2 primosome assembly protein PriA YP_977555.1 1602401 D 410289 CDS YP_977556.1 121637333 4697854 complement(1604386..1605210) 1 NC_008769.1 methyltransferase 1605210 4697854 BCG_1464c Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase YP_977556.1 1604386 R 410289 CDS YP_977557.1 121637334 4695861 1605379..1605861 1 NC_008769.1 transcriptional regulatory protein 1605861 4695861 BCG_1465 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977557.1 1605379 D 410289 CDS YP_977558.1 121637335 4697183 complement(1605933..1606757) 1 NC_008769.1 methyltransferase 1606757 4697183 BCG_1466c Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase YP_977558.1 1605933 R 410289 CDS YP_977559.1 121637336 4695478 1606954..1607892 1 NC_008769.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1607892 fmt 4695478 fmt Mycobacterium bovis BCG str. Pasteur 1173P2 methionyl-tRNA formyltransferase YP_977559.1 1606954 D 410289 CDS YP_977560.1 121637337 4697984 1607889..1609262 1 NC_008769.1 Differs from Rv1407 by 1aa, L427I; fmu protein 1609262 fmu 4697984 fmu Mycobacterium bovis BCG str. Pasteur 1173P2 fmu protein YP_977560.1 1607889 D 410289 CDS YP_977561.1 121637338 4697985 1609287..1609985 1 NC_008769.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 1609985 rpe 4697985 rpe Mycobacterium bovis BCG str. Pasteur 1173P2 ribulose-phosphate 3-epimerase YP_977561.1 1609287 D 410289 CDS YP_977562.1 121637339 4697711 1609982..1611001 1 NC_008769.1 Differs from Rv1409 by 2aa, N30K, T71A; bifunctional riboflavin biosynthesis protein RIBG: diaminohydroxyphosphoribosylaminopyrimidine deaminase + 5-amino-6-(5-phosphoribosylamino) uracil reductase 1611001 ribG 4697711 ribG Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional riboflavin biosynthesis protein RIBG: diaminohydroxyphosphoribosylaminopyrimidine deaminase + 5-amino-6-(5-phosphoribosylamino) uracil reductase YP_977562.1 1609982 D 410289 CDS YP_977563.1 121637340 4695902 complement(1610998..1612554) 1 NC_008769.1 aminoglycosides/tetracycline-transport integral membrane protein 1612554 4695902 BCG_1471c Mycobacterium bovis BCG str. Pasteur 1173P2 aminoglycosides/tetracycline-transport integral membrane protein YP_977563.1 1610998 R 410289 CDS YP_977564.1 121637341 4696284 complement(1612560..1613270) 1 NC_008769.1 lipoprotein lprG 1613270 lprG 4696284 lprG Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lprG YP_977564.1 1612560 R 410289 CDS YP_977565.1 121637342 4698141 1613355..1613960 1 NC_008769.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1613960 ribC 4698141 ribC Mycobacterium bovis BCG str. Pasteur 1173P2 riboflavin synthase subunit alpha YP_977565.1 1613355 D 410289 CDS YP_977566.1 121637343 4696890 1614174..1614689 1 NC_008769.1 hypothetical protein 1614689 4696890 BCG_1474 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977566.1 1614174 D 410289 CDS YP_977567.1 121637344 4695387 1614679..1615080 1 NC_008769.1 hypothetical protein 1615080 4695387 BCG_1475 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977567.1 1614679 D 410289 CDS YP_977568.1 121637345 4696694 1615185..1616462 1 NC_008769.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein 1616462 ribA2 4696694 ribA2 Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein YP_977568.1 1615185 D 410289 CDS YP_977569.1 121637346 4696889 1616477..1616941 1 NC_008769.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 1616941 ribH 4696889 ribH Mycobacterium bovis BCG str. Pasteur 1173P2 6,7-dimethyl-8-ribityllumazine synthase YP_977569.1 1616477 D 410289 CDS YP_977570.1 121637347 4695903 1616938..1617402 1 NC_008769.1 hypothetical protein 1617402 4695903 BCG_1478 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977570.1 1616938 D 410289 CDS YP_977571.1 121637348 4698067 1617427..1618113 1 NC_008769.1 lipoprotein lprH 1618113 lprH 4698067 lprH Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lprH YP_977571.1 1617427 D 410289 CDS YP_977572.1 121637349 4698142 1618293..1618766 1 NC_008769.1 hypothetical protein 1618766 4698142 BCG_1480 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977572.1 1618293 D 410289 CDS YP_977573.1 121637350 4696648 1618830..1620770 1 NC_008769.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1620770 uvrC 4696648 uvrC Mycobacterium bovis BCG str. Pasteur 1173P2 excinuclease ABC subunit C YP_977573.1 1618830 D 410289 CDS YP_977574.1 121637351 4697228 1620767..1621672 1 NC_008769.1 hypothetical protein 1621672 4697228 BCG_1482 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977574.1 1620767 D 410289 CDS YP_977575.1 121637352 4696789 1621669..1622697 1 NC_008769.1 Differs from Mb1457 by 1aa, A86V; hypothetical protein 1622697 4696789 BCG_1483 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977575.1 1621669 D 410289 CDS YP_977576.1 121637353 4697212 1622694..1623671 1 NC_008769.1 transcriptional regulatory protein whiA 1623671 whiA 4697212 whiA Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein whiA YP_977576.1 1622694 D 410289 CDS YP_977577.1 121637354 4695496 complement(1623681..1624442) 1 NC_008769.1 hypothetical protein 1624442 4695496 BCG_1485c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977577.1 1623681 R 410289 CDS YP_977578.1 121637355 4697619 1624446..1625825 1 NC_008769.1 Differs from Rv1425 by 1aa, L343P; hypothetical protein 1625825 4697619 BCG_1486 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977578.1 1624446 D 410289 CDS YP_977579.1 121637356 4697478 complement(1625847..1627109) 1 NC_008769.1 esterase lipO 1627109 lipO 4697478 lipO Mycobacterium bovis BCG str. Pasteur 1173P2 esterase lipO YP_977579.1 1625847 R 410289 CDS YP_977580.1 121637357 4698636 complement(1627109..1628716) 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1628716 fadD12 4698636 fadD12 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_977580.1 1627109 R 410289 CDS YP_977581.1 121637358 4696070 complement(1628720..1629547) 1 NC_008769.1 hypothetical protein 1629547 4696070 BCG_1489c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977581.1 1628720 R 410289 CDS YP_977582.1 121637359 4696689 1629666..1630934 1 NC_008769.1 hypothetical protein 1630934 4696689 BCG_1490 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977582.1 1629666 D 410289 CDS YP_977583.1 121637360 4696558 1631174..1632760 1 NC_008769.1 PE family protein 1632760 PE16 4696558 PE16 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_977583.1 1631174 D 410289 CDS YP_977584.1 121637361 4699006 1632871..1634640 1 NC_008769.1 Differs from Rv1431 by 2aa, T65N, Q455K; hypothetical protein 1634640 4699006 BCG_1492 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977584.1 1632871 D 410289 CDS YP_977585.1 121637362 4697497 1634637..1636058 1 NC_008769.1 dehydrogenase 1636058 4697497 BCG_1493 Mycobacterium bovis BCG str. Pasteur 1173P2 dehydrogenase YP_977585.1 1634637 D 410289 CDS YP_977586.1 121637363 4695641 1636222..1637043 1 NC_008769.1 Differs from Rv1433 and Mb1468 at C-terminal end due to 1bp deletion at position equivalent to H37Rv 1612222-1612222; hypothetical protein 1637043 4695641 BCG_1494 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977586.1 1636222 D 410289 CDS YP_977587.1 121637364 4697005 1637043..1637180 1 NC_008769.1 hypothetical protein 1637180 4697005 BCG_1495 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977587.1 1637043 D 410289 CDS YP_977588.1 121637365 4696727 complement(1637129..1637758) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, an in-frame insertion of 21 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (209 aa versus 202 aa). Differs from Rv1435c by 1aa, T67A; hypothetical protein 1637758 4696727 BCG_1496c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977588.1 1637129 R 410289 CDS YP_977589.1 121637366 4695593 1638115..1639134 1 NC_008769.1 glyceraldehyde 3-phosphate dehydrogenase gap 1639134 gap 4695593 gap Mycobacterium bovis BCG str. Pasteur 1173P2 glyceraldehyde 3-phosphate dehydrogenase gap YP_977589.1 1638115 D 410289 CDS YP_977590.1 121637367 4695746 1639137..1640375 1 NC_008769.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 1640375 pgk 4695746 pgk Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoglycerate kinase YP_977590.1 1639137 D 410289 CDS YP_977591.1 121637368 4698546 1640372..1641157 1 NC_008769.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1641157 tpiA 4698546 tpiA Mycobacterium bovis BCG str. Pasteur 1173P2 triosephosphate isomerase YP_977591.1 1640372 D 410289 CDS YP_977592.1 121637369 4696389 complement(1641769..1642194) 1 NC_008769.1 hypothetical protein 1642194 4696389 BCG_1500c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977592.1 1641769 R 410289 CDS YP_977593.1 121637370 4696624 1642645..1642878 1 NC_008769.1 preprotein translocase subunit SecG 1642878 secG 4696624 secG Mycobacterium bovis BCG str. Pasteur 1173P2 preprotein translocase subunit SecG YP_977593.1 1642645 D 410289 CDS YP_977594.1 121637371 4697880 complement(1643017..1644492) 1 NC_008769.1 Differs from Rv1441c by 1aa G236D and from Mb1476c by 1aa T354N; PE-PGRS family protein 1644492 PE_PGRS26 4697880 PE_PGRS26 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977594.1 1643017 R 410289 CDS YP_977595.1 121637372 4696178 1644599..1646899 1 NC_008769.1 biotin sulfoxide reductase bisC 1646899 bisC 4696178 bisC Mycobacterium bovis BCG str. Pasteur 1173P2 biotin sulfoxide reductase bisC YP_977595.1 1644599 D 410289 CDS YP_977596.1 121637373 4695781 complement(1647015..1647500) 1 NC_008769.1 hypothetical protein 1647500 4695781 BCG_1504c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977596.1 1647015 R 410289 CDS YP_977597.1 121637374 4696240 complement(1648099..1648509) 1 NC_008769.1 hypothetical protein 1648509 4696240 BCG_1505c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977597.1 1648099 R 410289 CDS YP_977598.1 121637375 4697569 complement(1648526..1649269) 1 NC_008769.1 6-phosphogluconolactonase devB 1649269 devB 4697569 devB Mycobacterium bovis BCG str. Pasteur 1173P2 6-phosphogluconolactonase devB YP_977598.1 1648526 R 410289 CDS YP_977599.1 121637376 4698619 complement(1649266..1650177) 1 NC_008769.1 Differs from Rv1446v by 1aa P192R; OXPP cycle protein opcA 1650177 opcA 4698619 opcA Mycobacterium bovis BCG str. Pasteur 1173P2 OXPP cycle protein opcA YP_977599.1 1649266 R 410289 CDS YP_977600.1 121637377 4698679 complement(1650230..1651774) 1 NC_008769.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1651774 zwf2 4698679 zwf2 Mycobacterium bovis BCG str. Pasteur 1173P2 glucose-6-phosphate 1-dehydrogenase YP_977600.1 1650230 R 410289 CDS YP_977601.1 121637378 4695914 complement(1651771..1652892) 1 NC_008769.1 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase 1652892 tal 4695914 tal Mycobacterium bovis BCG str. Pasteur 1173P2 transaldolase YP_977601.1 1651771 R 410289 CDS YP_977602.1 121637379 4696338 complement(1652909..1655011) 1 NC_008769.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1655011 tkt 4696338 tkt Mycobacterium bovis BCG str. Pasteur 1173P2 transketolase YP_977602.1 1652909 R 410289 CDS YP_977603.1 121637380 4695913 complement(1655450..1659649) 1 NC_008769.1 In Mycobacterium bovis, insertions of 27 bp, 207 bp and 27 bp, substitutions of 60 bp to 63 bp and 11 bp, and a 27 bp deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (1408 aa versus 1329 aa). In Mycobacterium bovis BCG Pasteur one 27bp-insertion is missing, leading to a product of 1399 aa; PE-PGRS family protein 1659649 PE_PGRS27 4695913 PE_PGRS27 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977603.1 1655450 R 410289 CDS YP_977604.1 121637381 4696179 1660051..1660977 1 NC_008769.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 1660977 ctaB 4696179 ctaB Mycobacterium bovis BCG str. Pasteur 1173P2 protoheme IX farnesyltransferase YP_977604.1 1660051 D 410289 CDS YP_977605.1 121637382 4697935 complement(1661026..1663248) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, a insertion of 51 bp, several substitutions and a deletion of 207 bp, lead to a smaller product compared to its homolog Mycobacterium bovis (740 aa versus 795 aa); PE-PGRS family protein 1663248 PE_PGRS28 4697935 PE_PGRS28 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977605.1 1661026 R 410289 CDS YP_977606.1 121637383 4696180 1663400..1664665 1 NC_008769.1 Differs from Rv1453 by 1aa Q405P; transcriptional activator protein 1664665 4696180 BCG_1514 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional activator protein YP_977606.1 1663400 D 410289 CDS YP_977607.1 121637384 4697000 complement(1664693..1665679) 1 NC_008769.1 quinone reductase qor 1665679 qor 4697000 qor Mycobacterium bovis BCG str. Pasteur 1173P2 quinone reductase qor YP_977607.1 1664693 R 410289 CDS YP_977608.1 121637385 4695435 1665699..1666562 1 NC_008769.1 hypothetical protein 1666562 4695435 BCG_1516 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977608.1 1665699 D 410289 CDS YP_977609.1 121637386 4697458 complement(1666512..1667444) 1 NC_008769.1 unidentified antibiotic-transport integral membrane ABC transporter 1667444 4697458 BCG_1517c Mycobacterium bovis BCG str. Pasteur 1173P2 unidentified antibiotic-transport integral membrane ABC transporter YP_977609.1 1666512 R 410289 CDS YP_977610.1 121637387 4697566 complement(1667556..1668341) 1 NC_008769.1 unidentified antibiotic-transport integral membrane ABC transporter 1668341 4697566 BCG_1518c Mycobacterium bovis BCG str. Pasteur 1173P2 unidentified antibiotic-transport integral membrane ABC transporter YP_977610.1 1667556 R 410289 CDS YP_977611.1 121637388 4698819 complement(1668338..1669279) 1 NC_008769.1 unidentified antibiotic-transport ATP-binding protein ABC transporter 1669279 4698819 BCG_1519c Mycobacterium bovis BCG str. Pasteur 1173P2 unidentified antibiotic-transport ATP-binding protein ABC transporter YP_977611.1 1668338 R 410289 CDS YP_977612.1 121637389 4695558 complement(1669435..1671210) 1 NC_008769.1 Differs from Rv1459c by 1aa, E113K; hypothetical protein 1671210 4695558 BCG_1520c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977612.1 1669435 R 410289 CDS YP_977613.1 121637390 4698980 1671258..1672064 1 NC_008769.1 Differs from Rv1460 by 2aa, F198I, V265 and from Mb1495 by 1aa, F198I; transcriptional regulatory protein 1672064 4698980 BCG_1521 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977613.1 1671258 D 410289 CDS YP_977614.1 121637391 4696064 1672061..1674601 1 NC_008769.1 hypothetical protein 1674601 4696064 BCG_1522 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977614.1 1672061 D 410289 CDS YP_977615.1 121637392 4697462 1674598..1675791 1 NC_008769.1 Differs from Rv1462 by 1aa, D183N; hypothetical protein 1675791 4697462 BCG_1523 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977615.1 1674598 D 410289 CDS YP_977616.1 121637393 4697207 1675788..1676588 1 NC_008769.1 ABC transporter ATP-binding protein 1676588 4697207 BCG_1524 Mycobacterium bovis BCG str. Pasteur 1173P2 ABC transporter ATP-binding protein YP_977616.1 1675788 D 410289 CDS YP_977617.1 121637394 4695676 1676590..1677843 1 NC_008769.1 cysteine desulfurase csd 1677843 csd 4695676 csd Mycobacterium bovis BCG str. Pasteur 1173P2 cysteine desulfurase csd YP_977617.1 1676590 D 410289 CDS YP_977618.1 121637395 4697983 1677840..1678328 1 NC_008769.1 nitrogen fixation-like protein 1678328 4697983 BCG_1526 Mycobacterium bovis BCG str. Pasteur 1173P2 nitrogen fixation-like protein YP_977618.1 1677840 D 410289 CDS YP_977619.1 121637396 4696091 1678303..1678650 1 NC_008769.1 hypothetical protein 1678650 4696091 BCG_1527 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977619.1 1678303 D 410289 CDS YP_977620.1 121637397 4698487 complement(1678745..1680574) 1 NC_008769.1 acyl-CoA dehydrogenase fadE15 1680574 fadE15 4698487 fadE15 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE15 YP_977620.1 1678745 R 410289 CDS YP_977621.1 121637398 4697442 complement(1680681..1681793) 1 NC_008769.1 PE-PGRS family protein 1681793 PE_PGRS29 4697442 PE_PGRS29 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977621.1 1680681 R 410289 CDS YP_977622.1 121637399 4696181 1682035..1684008 1 NC_008769.1 cation transporter P-type atpase D ctpD 1684008 ctpD 4696181 ctpD Mycobacterium bovis BCG str. Pasteur 1173P2 cation transporter P-type atpase D ctpD YP_977622.1 1682035 D 410289 CDS YP_977623.1 121637400 4696169 1684052..1684426 1 NC_008769.1 thioredoxin trxA 1684426 trxA 4696169 trxA Mycobacterium bovis BCG str. Pasteur 1173P2 thioredoxin trxA YP_977623.1 1684052 D 410289 CDS YP_977624.1 121637401 4696831 1684442..1684813 1 NC_008769.1 thioredoxin trxB1 1684813 trxB1 4696831 trxB1 Mycobacterium bovis BCG str. Pasteur 1173P2 thioredoxin trxB1 YP_977624.1 1684442 D 410289 CDS YP_977625.1 121637402 4696832 1684835..1685692 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1685692 echA12 4696832 echA12 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_977625.1 1684835 D 410289 CDS YP_977626.1 121637403 4697215 1685728..1687356 1 NC_008769.1 macrolide-transport ATP-binding protein ABC transporter 1687356 4697215 BCG_1534 Mycobacterium bovis BCG str. Pasteur 1173P2 macrolide-transport ATP-binding protein ABC transporter YP_977626.1 1685728 D 410289 CDS YP_977627.1 121637404 4697105 1687453..1687644 1 NC_008769.1 Differs from Rv1473A by 1aa, P60S; transcriptional regulatory protein 1687644 4697105 BCG_1535 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977627.1 1687453 D 410289 CDS YP_977628.1 121637405 4696608 complement(1687713..1688276) 1 NC_008769.1 transcriptional regulatory protein 1688276 4696608 BCG_1536c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977628.1 1687713 R 410289 CDS YP_977629.1 121637406 4696216 complement(1688287..1691118) 1 NC_008769.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1691118 acn 4696216 acn Mycobacterium bovis BCG str. Pasteur 1173P2 aconitate hydratase YP_977629.1 1688287 R 410289 CDS YP_977630.1 121637407 4699040 1691276..1691836 1 NC_008769.1 hypothetical protein 1691836 4699040 BCG_1538 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977630.1 1691276 D 410289 CDS YP_977631.1 121637408 4696675 1692062..1693480 1 NC_008769.1 invasion protein 1693480 4696675 BCG_1539 Mycobacterium bovis BCG str. Pasteur 1173P2 invasion protein YP_977631.1 1692062 D 410289 CDS YP_977632.1 121637409 4695541 1693491..1694216 1 NC_008769.1 invasion protein 1694216 4695541 BCG_1540 Mycobacterium bovis BCG str. Pasteur 1173P2 invasion protein YP_977632.1 1693491 D 410289 CDS YP_977633.1 121637410 4695472 1694355..1695488 1 NC_008769.1 transcriptional regulatory protein moxR1 1695488 moxR1 4695472 moxR1 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein moxR1 YP_977633.1 1694355 D 410289 CDS YP_977634.1 121637411 4698908 1695485..1696438 1 NC_008769.1 hypothetical protein 1696438 4698908 BCG_1542 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977634.1 1695485 D 410289 CDS YP_977635.1 121637412 4696094 1696449..1697456 1 NC_008769.1 Differs from Rv1481 and Mb1517 by 1aa, D254N; hypothetical protein 1697456 4696094 BCG_1543 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977635.1 1696449 D 410289 CDS YP_977636.1 121637413 4696075 complement(1697529..1698371) 1 NC_008769.1 hypothetical protein 1698371 4696075 BCG_1544c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977636.1 1697529 R 410289 CDS YP_977637.1 121637414 4696269 1698512..1699255 1 NC_008769.1 3-oxoacyl-ACP reductase 1699255 fabG1 4696269 fabG1 Mycobacterium bovis BCG str. Pasteur 1173P2 3-oxoacyl-ACP reductase YP_977637.1 1698512 D 410289 CDS YP_977638.1 121637415 4696660 1699274..1700083 1 NC_008769.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 1700083 inhA 4696660 inhA Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-ACP reductase YP_977638.1 1699274 D 410289 CDS YP_977639.1 121637416 4697076 1700089..1701123 1 NC_008769.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 1701123 hemH 4697076 hemH Mycobacterium bovis BCG str. Pasteur 1173P2 ferrochelatase YP_977639.1 1700089 D 410289 CDS YP_977640.1 121637417 4698932 complement(1700985..1701956) 1 NC_008769.1 First 270 aa identical to Mb1522c and Rv1486c (but differs by 1aa, N198K), then frameshifts due to extra base, g, at position equivalent to Mycobacterium tuberculosis strain H37Rv position 1676073-1676074; hypothetical protein 1701956 4698932 BCG_1548c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977640.1 1700985 R 410289 CDS YP_977641.1 121637418 4697672 1702014..1702448 1 NC_008769.1 hypothetical protein 1702448 4697672 BCG_1549 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977641.1 1702014 D 410289 CDS YP_977642.1 121637419 4697530 1702470..1703615 1 NC_008769.1 hypothetical protein 1703615 4697530 BCG_1550 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977642.1 1702470 D 410289 CDS YP_977643.1 121637420 4696581 1703625..1703981 1 NC_008769.1 hypothetical protein 1703981 4696581 BCG_1551 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977643.1 1703625 D 410289 CDS YP_977644.1 121637421 4697027 1704015..1704245 1 NC_008769.1 hypothetical protein 1704245 4697027 BCG_1552 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977644.1 1704015 D 410289 CDS YP_977645.1 121637422 4695643 1704395..1705702 1 NC_008769.1 hypothetical protein 1705702 4695643 BCG_1553 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977645.1 1704395 D 410289 CDS YP_977646.1 121637423 4697509 complement(1706281..1707039) 1 NC_008769.1 hypothetical protein 1707039 4697509 BCG_1554c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977646.1 1706281 R 410289 CDS YP_977647.1 121637424 4695468 1707230..1709077 1 NC_008769.1 methylmalonyl-CoA mutase small subunit mutA 1709077 mutA 4695468 mutA Mycobacterium bovis BCG str. Pasteur 1173P2 methylmalonyl-CoA mutase small subunit mutA YP_977647.1 1707230 D 410289 CDS YP_977648.1 121637425 4697971 1709078..1711330 1 NC_008769.1 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 1711330 mutB 4697971 mutB Mycobacterium bovis BCG str. Pasteur 1173P2 methylmalonyl-CoA mutase YP_977648.1 1709078 D 410289 CDS YP_977649.1 121637426 4697972 1711344..1711646 1 NC_008769.1 Differs from Rv1494 and Mb1531 by 1aa, L12S; hypothetical protein 1711646 4697972 BCG_1557 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977649.1 1711344 D 410289 CDS YP_977650.1 121637427 4697916 1711643..1711960 1 NC_008769.1 hypothetical protein 1711960 4697916 BCG_1558 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977650.1 1711643 D 410289 CDS YP_977651.1 121637428 4697471 1711957..1712961 1 NC_008769.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 1712961 4697471 BCG_1559 Mycobacterium bovis BCG str. Pasteur 1173P2 arginine/ornithine transport system ATPase YP_977651.1 1711957 D 410289 CDS YP_977652.1 121637429 4697545 1713014..1714303 1 NC_008769.1 esterase lipL 1714303 lipL 4697545 lipL Mycobacterium bovis BCG str. Pasteur 1173P2 esterase lipL YP_977652.1 1713014 D 410289 CDS YP_977653.1 121637430 4698633 complement(1714376..1714993) 1 NC_008769.1 Differs from Rv1498c by 1aa, H191R; methyltransferase 1714993 4698633 BCG_1561c Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase YP_977653.1 1714376 R 410289 CDS YP_977654.1 121637431 4697922 complement(1715207..1715398) 1 NC_008769.1 In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a single base transition (a-g) at the 5' start leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (63 aa versus 70 aa); hypothetical protein 1715398 4697922 BCG_1562c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977654.1 1715207 R 410289 CDS YP_977655.1 121637432 4696996 1715480..1715878 1 NC_008769.1 hypothetical protein 1715878 4696996 BCG_1563 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977655.1 1715480 D 410289 CDS YP_977656.1 121637433 4697892 1715923..1716951 1 NC_008769.1 Differs from Rv1500 and Mb1538 by 1aa, E45D; glycosyltransferase 1716951 4697892 BCG_1564 Mycobacterium bovis BCG str. Pasteur 1173P2 glycosyltransferase YP_977656.1 1715923 D 410289 CDS YP_977657.1 121637434 4696802 1716963..1717784 1 NC_008769.1 hypothetical protein 1717784 4696802 BCG_1565 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977657.1 1716963 D 410289 CDS YP_977658.1 121637435 4697929 1717997..1718896 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur and Mycobacterium tuberculosis strain H37Rv, Rv1502 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv1502 into 2 parts, Mb1540 and Mb1541. Differs from Rv1502 by 1aa, C213Y; hypothetical protein 1718896 4697929 BCG_1566 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977658.1 1717997 D 410289 CDS YP_977659.1 121637436 4696803 complement(1719069..1720217) 1 NC_008769.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 1720217 4696803 BCG_1567c Mycobacterium bovis BCG str. Pasteur 1173P2 TDP-4-oxo-6-deoxy-D-glucose transaminase YP_977659.1 1719069 R 410289 CDS YP_977660.1 121637437 4696811 complement(1720354..1721019) 1 NC_008769.1 hypothetical protein 1721019 4696811 BCG_1568c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977660.1 1720354 R 410289 CDS YP_977661.1 121637438 4697810 1721212..1721976 1 NC_008769.1 Differs from Rv1517 by 1aa, F188L; hypothetical protein 1721976 4697810 BCG_1569 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977661.1 1721212 D 410289 CDS YP_977662.1 121637439 4697936 1721985..1722944 1 NC_008769.1 Differs from Rv1518 by 2aa, R266S, L317M; hypothetical protein 1722944 4697936 BCG_1570 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977662.1 1721985 D 410289 CDS YP_977663.1 121637440 4697425 1723074..1723343 1 NC_008769.1 hypothetical protein 1723343 4697425 BCG_1571 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977663.1 1723074 D 410289 CDS YP_977664.1 121637441 4697446 1723369..1724409 1 NC_008769.1 sugar transferase 1724409 4697446 BCG_1572 Mycobacterium bovis BCG str. Pasteur 1173P2 sugar transferase YP_977664.1 1723369 D 410289 CDS YP_977665.1 121637442 4696590 1724643..1726394 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1726394 fadD25 4696590 fadD25 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_977665.1 1724643 D 410289 CDS YP_977666.1 121637443 4697740 complement(1726630..1729953) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transversion (c-a) creating a stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1107 aa versus 1146 aa). Differs from Rv1522c (1146 aa) by 1aa, P381S, and from Mb1549c, (1107 aa) by 2aa, T204A, S947N; transmembrane transport protein mmpL12 1729953 mmpL12 4697740 mmpL12 Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane transport protein mmpL12 YP_977666.1 1726630 R 410289 CDS YP_977667.1 121637444 4697542 1729994..1731037 1 NC_008769.1 methyltransferase 1731037 4697542 BCG_1575 Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase YP_977667.1 1729994 D 410289 CDS YP_977668.1 121637445 4695485 1731067..1732311 1 NC_008769.1 glycosyltransferase 1732311 4695485 BCG_1576 Mycobacterium bovis BCG str. Pasteur 1173P2 glycosyltransferase YP_977668.1 1731067 D 410289 CDS YP_977669.1 121637446 4695386 1732358..1733143 1 NC_008769.1 rhamnosyl transferase wbbL2 1733143 wbbL2 4695386 wbbL2 Mycobacterium bovis BCG str. Pasteur 1173P2 rhamnosyl transferase wbbL2 YP_977669.1 1732358 D 410289 CDS YP_977670.1 121637447 4695495 complement(1733121..1734401) 1 NC_008769.1 glycosyltransferase 1734401 4695495 BCG_1578c Mycobacterium bovis BCG str. Pasteur 1173P2 glycosyltransferase YP_977670.1 1733121 R 410289 CDS YP_977671.1 121637448 4697564 complement(1734424..1740750) 1 NC_008769.1 Differs from Rv1527c by 2aa, T532P, L1439F; polyketide synthase pks5 1740750 pks5 4697564 pks5 Mycobacterium bovis BCG str. Pasteur 1173P2 polyketide synthase pks5 YP_977671.1 1734424 R 410289 CDS YP_977672.1 121637449 4696576 complement(1741294..1741791) 1 NC_008769.1 polyketide synthase associated protein papA4 1741791 papA4 4696576 papA4 Mycobacterium bovis BCG str. Pasteur 1173P2 polyketide synthase associated protein papA4 YP_977672.1 1741294 R 410289 CDS YP_977673.1 121637450 4698057 1741843..1743597 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1743597 fadD24 4698057 fadD24 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_977673.1 1741843 D 410289 CDS YP_977674.1 121637451 4697574 1743714..1744817 1 NC_008769.1 Differs from Rv1530 and Mb1557 by 1aa, L330P; alcohol dehydrogenase adh 1744817 adh 4697574 adh Mycobacterium bovis BCG str. Pasteur 1173P2 alcohol dehydrogenase adh YP_977674.1 1743714 D 410289 CDS YP_977675.1 121637452 4696478 1744814..1745380 1 NC_008769.1 hypothetical protein 1745380 4696478 BCG_1583 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977675.1 1744814 D 410289 CDS YP_977676.1 121637453 4699168 complement(1745457..1745891) 1 NC_008769.1 hypothetical protein 1745891 4699168 BCG_1584c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977676.1 1745457 R 410289 CDS YP_977677.1 121637454 4697591 1745951..1747078 1 NC_008769.1 hypothetical protein 1747078 4697591 BCG_1585 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977677.1 1745951 D 410289 CDS YP_977678.1 121637455 4695725 1747075..1747752 1 NC_008769.1 transcriptional regulator 1747752 4695725 BCG_1586 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulator YP_977678.1 1747075 D 410289 CDS YP_977679.1 121637456 4696085 1748317..1748553 1 NC_008769.1 hypothetical protein 1748553 4696085 BCG_1587 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977679.1 1748317 D 410289 CDS YP_977680.1 121637457 4697640 1748860..1751985 1 NC_008769.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase 1751985 ileS 4697640 ileS Mycobacterium bovis BCG str. Pasteur 1173P2 isoleucyl-tRNA synthetase YP_977680.1 1748860 D 410289 CDS YP_977681.1 121637458 4696224 1752197..1753588 1 NC_008769.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 1753588 dinX 4696224 dinX Mycobacterium bovis BCG str. Pasteur 1173P2 DNA polymerase IV YP_977681.1 1752197 D 410289 CDS YP_977682.1 121637459 4696610 complement(1753553..1754533) 1 NC_008769.1 L-aparaginase ansA 1754533 ansA 4696610 ansA Mycobacterium bovis BCG str. Pasteur 1173P2 L-aparaginase ansA YP_977682.1 1753553 R 410289 CDS YP_977683.1 121637460 4695657 1754585..1755193 1 NC_008769.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1755193 lspA 4695657 lspA Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein signal peptidase YP_977683.1 1754585 D 410289 CDS YP_977684.1 121637461 4697259 1755186..1756112 1 NC_008769.1 hypothetical protein 1756112 4697259 BCG_1592 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977684.1 1755186 D 410289 CDS YP_977685.1 121637462 4696772 complement(1756119..1756712) 1 NC_008769.1 lipoprotein lprI 1756712 lprI 4696772 lprI Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lprI YP_977685.1 1756119 R 410289 CDS YP_977686.1 121637463 4698143 complement(1756767..1757177) 1 NC_008769.1 hemoglobin glbN 1757177 glbN 4698143 glbN Mycobacterium bovis BCG str. Pasteur 1173P2 hemoglobin glbN YP_977686.1 1756767 R 410289 CDS YP_977687.1 121637464 4697396 1757405..1758430 1 NC_008769.1 fatty acyl-CoA reductase 1758430 4697396 BCG_1595 Mycobacterium bovis BCG str. Pasteur 1173P2 fatty acyl-CoA reductase YP_977687.1 1757405 D 410289 CDS YP_977688.1 121637465 4696690 1758435..1758533 1 NC_008769.1 BCG_1596; In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, Rv1544 and Mb1571 exist as a single gene. In Mycobacterium bovis BCG Pasteur, two genes exist as a result of a 10 bp deletion that has occurred at a position equivalent to H37Rv position 1746147-1746156I; hypothetical protein 1758533 4696690 BCG_1596 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977688.1 1758435 D 410289 CDS YP_977689.1 121637466 4696244 1758533..1759228 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, Rv1544 and Mb1571 exist as a single gene. In Mycobacterium bovis BCG Pasteur, two genes exist as a result of a 10 bp deletion that has occurred at a position equivalent to H37Rv position 1746147-1746156I; ketoacyl reductase 1759228 4696244 BCG_1597 Mycobacterium bovis BCG str. Pasteur 1173P2 ketoacyl reductase YP_977689.1 1758533 D 410289 CDS YP_977690.1 121637467 4697671 1759250..1759477 1 NC_008769.1 hypothetical protein 1759477 4697671 BCG_1598 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977690.1 1759250 D 410289 CDS YP_977691.1 121637468 4697669 1759526..1759957 1 NC_008769.1 hypothetical protein 1759957 4697669 BCG_1599 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977691.1 1759526 D 410289 CDS YP_977692.1 121637469 4695706 1760025..1763579 1 NC_008769.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 1763579 dnaE 4695706 dnaE Mycobacterium bovis BCG str. Pasteur 1173P2 DNA polymerase III subunit alpha YP_977692.1 1760025 D 410289 CDS YP_977693.1 121637470 4696096 complement(1763628..1765664) 1 NC_008769.1 Differs from Rv1548c by 1aa, G258D, and from Mb1575c by 1aa, V68A; PPE family protein 1765664 PPE21 4696096 PPE21 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977693.1 1763628 R 410289 CDS YP_977694.1 121637471 4698627 1765821..1767764 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1549 and Rv1550 exist as 2 genes. In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, two single base insertions (*-c and *-c) lead to a single product. Differs from Rv1550 by 1aa, S362L; fatty-acid-CoA ligase FadD11 1767764 fadD11 4698627 fadD11 Mycobacterium bovis BCG str. Pasteur 1173P2 fatty-acid-CoA ligase FadD11 YP_977694.1 1765821 D 410289 CDS YP_977695.1 121637472 4695422 1767778..1769643 1 NC_008769.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 1769643 plsB1 4695422 plsB1 Mycobacterium bovis BCG str. Pasteur 1173P2 glycerol-3-phosphate acyltransferase YP_977695.1 1767778 D 410289 CDS YP_977696.1 121637473 4695943 1770013..1771764 1 NC_008769.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 1771764 frdA 4695943 frdA Mycobacterium bovis BCG str. Pasteur 1173P2 fumarate reductase flavoprotein subunit YP_977696.1 1770013 D 410289 CDS YP_977697.1 121637474 4697657 1771767..1772897 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1553 and Rv1554 exist as 2 genes. In Mycobacterium bovis, a 4 bp insertion (*-gggg) leads to a single product and in Mycobacterium bovis BCG Pasteur a 10 bp insertion at position equivalent to H37Rv 1760171-1760172 leads to insertion of two additional Gly codons; fumarate reductase frdC 1772897 frdBC 4697657 frdBC Mycobacterium bovis BCG str. Pasteur 1173P2 fumarate reductase frdC YP_977697.1 1771767 D 410289 CDS YP_977698.1 121637475 4697658 1772894..1773271 1 NC_008769.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 1773271 frdD 4697658 frdD Mycobacterium bovis BCG str. Pasteur 1173P2 fumarate reductase subunit D YP_977698.1 1772894 D 410289 CDS YP_977699.1 121637476 4697659 1773339..1773947 1 NC_008769.1 regulatory protein 1773947 4697659 BCG_1607 Mycobacterium bovis BCG str. Pasteur 1173P2 regulatory protein YP_977699.1 1773339 D 410289 CDS YP_977700.1 121637477 4697034 1774086..1774532 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a 2153 bp insertion leads to a new protein with no equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to the TbD1 region; membrane protein mmpS6 1774532 mmpS6 4697034 mmpS6 Mycobacterium bovis BCG str. Pasteur 1173P2 membrane protein mmpS6 YP_977700.1 1774086 D 410289 CDS YP_977701.1 121637478 4697598 1774529..1777432 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 2153 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Belongs to the TbD1 region; transmembrane transport protein mmpL6 1777432 mmpL6 4697598 mmpL6 Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane transport protein mmpL6 YP_977701.1 1774529 D 410289 CDS YP_977702.1 121637479 4696172 1777442..1777888 1 NC_008769.1 hypothetical protein 1777888 4696172 BCG_1610 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977702.1 1777442 D 410289 CDS YP_977703.1 121637480 4698478 1777923..1779212 1 NC_008769.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 1779212 ilvA 4698478 ilvA Mycobacterium bovis BCG str. Pasteur 1173P2 threonine dehydratase YP_977703.1 1777923 D 410289 CDS YP_977704.1 121637481 4696225 1779250..1779468 1 NC_008769.1 hypothetical protein 1779468 4696225 BCG_1612 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977704.1 1779250 D 410289 CDS YP_977705.1 121637482 4696560 1779474..1779878 1 NC_008769.1 hypothetical protein 1779878 4696560 BCG_1613 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977705.1 1779474 D 410289 CDS YP_977706.1 121637483 4695559 complement(1779895..1780455) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, treZa and treZb exist as a single gene, treZ. In Mycobacterium bovis BCG Pasteur, a single base deletion at position equivalent to H37Rv 1766233-1766233 leads to frameshift and two genes, treZa and treZb; maltooligosyltrehalose trehalohydrolase TreZ 1780455 treZb 4695559 treZb Mycobacterium bovis BCG str. Pasteur 1173P2 maltooligosyltrehalose trehalohydrolase TreZ YP_977706.1 1779895 R 410289 CDS YP_977707.1 121637484 4697328 complement(1780452..1781636) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, treZa and treZb exist as a single gene, treZ. In Mycobacterium bovis BCG Pasteur, a single base deletion at position equivalent to H37Rv 1766233-1766233 leads to frameshift and two genes, treZa and treZb; maltooligosyltrehalose trehalohydrolase TreZ 1781636 treZa 4697328 treZa Mycobacterium bovis BCG str. Pasteur 1173P2 maltooligosyltrehalose trehalohydrolase TreZ YP_977707.1 1780452 R 410289 CDS YP_977708.1 121637485 4697327 complement(1781629..1783926) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and in Mycobacterium tuberculosis strain H37Rv, treY exists as a single gene. In Mycobacterium bovis, a large deletion of 806 bp, RD17, splits Rv1563c into two parts, treYa and treYb; maltooligosyltrehalose synthase TreY 1783926 treY 4697327 treY Mycobacterium bovis BCG str. Pasteur 1173P2 maltooligosyltrehalose synthase TreY YP_977708.1 1781629 R 410289 CDS YP_977709.1 121637486 4696823 complement(1783930..1786095) 1 NC_008769.1 maltooligosyltrehalose synthase TreX 1786095 treX 4696823 treX Mycobacterium bovis BCG str. Pasteur 1173P2 maltooligosyltrehalose synthase TreX YP_977709.1 1783930 R 410289 CDS YP_977710.1 121637487 4696822 complement(1786134..1788323) 1 NC_008769.1 hypothetical protein 1788323 4696822 BCG_1618c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977710.1 1786134 R 410289 CDS YP_977711.1 121637488 4696813 complement(1788422..1789114) 1 NC_008769.1 inv protein 1789114 4696813 BCG_1619c Mycobacterium bovis BCG str. Pasteur 1173P2 inv protein YP_977711.1 1788422 R 410289 CDS YP_977712.1 121637489 4697678 complement(1789354..1789638) 1 NC_008769.1 hypothetical protein 1789638 4697678 BCG_1620c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977712.1 1789354 R 410289 CDS YP_977713.1 121637490 4696087 1789886..1791199 1 NC_008769.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1791199 bioA 4696087 bioA Mycobacterium bovis BCG str. Pasteur 1173P2 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_977713.1 1789886 D 410289 CDS YP_977714.1 121637491 4695858 1791196..1792356 1 NC_008769.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 1792356 bioF1 4695858 bioF1 Mycobacterium bovis BCG str. Pasteur 1173P2 8-amino-7-oxononanoate synthase YP_977714.1 1791196 D 410289 CDS YP_977715.1 121637492 4696194 1792353..1793033 1 NC_008769.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1793033 bioD 4696194 bioD Mycobacterium bovis BCG str. Pasteur 1173P2 dithiobiotin synthetase YP_977715.1 1792353 D 410289 CDS YP_977716.1 121637493 4699259 1793033..1793542 1 NC_008769.1 hypothetical protein 1793542 4699259 BCG_1624 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977716.1 1793033 D 410289 CDS YP_977717.1 121637494 4698167 complement(1793688..1794644) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis, Rv1587c possibly exists as a pseudogene that has been disrupted when the phage entered. In Mycobacterium bovis BCG Pasteur, the prophage is absent and the C-terminal part of protein differs accordingly; hypothetical protein 1794644 4698167 BCG_1625c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977717.1 1793688 R 410289 CDS YP_977718.1 121637495 4696700 complement(1794415..1795083) 1 NC_008769.1 Differs from Rv1588c by 3aa, T63A, L91R, I131V; hypothetical protein 1795083 4696700 BCG_1626c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977718.1 1794415 R 410289 CDS YP_977719.1 121637496 4696627 1795531..1796580 1 NC_008769.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase 1796580 bioB 4696627 bioB Mycobacterium bovis BCG str. Pasteur 1173P2 biotin synthase YP_977719.1 1795531 D 410289 CDS YP_977720.1 121637497 4697186 1796581..1796820 1 NC_008769.1 hypothetical protein 1796820 4697186 BCG_1628 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977720.1 1796581 D 410289 CDS YP_977721.1 121637498 4697603 1796817..1797482 1 NC_008769.1 hypothetical protein 1797482 4697603 BCG_1629 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977721.1 1796817 D 410289 CDS YP_977722.1 121637499 4697676 complement(1797647..1798987) 1 NC_008769.1 Differs from Rv1592c by 1aa, V322I; hypothetical protein 1798987 4697676 BCG_1630c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977722.1 1797647 R 410289 CDS YP_977723.1 121637500 4696542 complement(1799244..1799954) 1 NC_008769.1 hypothetical protein 1799954 4696542 BCG_1631c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977723.1 1799244 R 410289 CDS YP_977724.1 121637501 4695469 1800003..1801052 1 NC_008769.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 1801052 nadA 4695469 nadA Mycobacterium bovis BCG str. Pasteur 1173P2 quinolinate synthetase YP_977724.1 1800003 D 410289 CDS YP_977725.1 121637502 4695713 1801052..1802635 1 NC_008769.1 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 1802635 nadB 4695713 nadB Mycobacterium bovis BCG str. Pasteur 1173P2 L-aspartate oxidase YP_977725.1 1801052 D 410289 CDS YP_977726.1 121637503 4695714 1802635..1803492 1 NC_008769.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 1803492 nadC 4695714 nadC Mycobacterium bovis BCG str. Pasteur 1173P2 nicotinate-nucleotide pyrophosphorylase YP_977726.1 1802635 D 410289 CDS YP_977727.1 121637504 4695715 1803541..1804299 1 NC_008769.1 Differs from Rv1597 by 2aa, D21G, M93L, and from Mb1623 by 1aa, M93L; hypothetical protein 1804299 4695715 BCG_1635 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977727.1 1803541 D 410289 CDS YP_977728.1 121637505 4695671 complement(1804320..1804730) 1 NC_008769.1 hypothetical protein 1804730 4695671 BCG_1636c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977728.1 1804320 R 410289 CDS YP_977729.1 121637506 4696261 1804830..1806146 1 NC_008769.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1806146 hisD 4696261 hisD Mycobacterium bovis BCG str. Pasteur 1173P2 histidinol dehydrogenase YP_977729.1 1804830 D 410289 CDS YP_977730.1 121637507 4696168 1806143..1807285 1 NC_008769.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1807285 hisC1 4696168 hisC1 Mycobacterium bovis BCG str. Pasteur 1173P2 histidinol-phosphate aminotransferase YP_977730.1 1806143 D 410289 CDS YP_977731.1 121637508 4696166 1807282..1807914 1 NC_008769.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 1807914 hisB 4696166 hisB Mycobacterium bovis BCG str. Pasteur 1173P2 imidazoleglycerol-phosphate dehydratase YP_977731.1 1807282 D 410289 CDS YP_977732.1 121637509 4696165 1807911..1808531 1 NC_008769.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1808531 hisH 4696165 hisH Mycobacterium bovis BCG str. Pasteur 1173P2 imidazole glycerol phosphate synthase subunit HisH YP_977732.1 1807911 D 410289 CDS YP_977733.1 121637510 4696068 1808541..1809278 1 NC_008769.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; phosphoribosyl isomerase A 1809278 hisA 4696068 hisA Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoribosyl isomerase A YP_977733.1 1808541 D 410289 CDS YP_977734.1 121637511 4696164 1809286..1810098 1 NC_008769.1 Differs from Rv1604 by 3aa, H93Y, Q124P, L251P; inositol-monophosphatase impA 1810098 impA 4696164 impA Mycobacterium bovis BCG str. Pasteur 1173P2 inositol-monophosphatase impA YP_977734.1 1809286 D 410289 CDS YP_977735.1 121637512 4698976 1810100..1810903 1 NC_008769.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 1810903 hisF 4698976 hisF Mycobacterium bovis BCG str. Pasteur 1173P2 imidazole glycerol phosphate synthase subunit HisF YP_977735.1 1810100 D 410289 CDS YP_977736.1 121637513 4696066 1810900..1811247 1 NC_008769.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase 1811247 hisI 4696066 hisI Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoribosyl-AMP cyclohydrolase YP_977736.1 1810900 D 410289 CDS YP_977737.1 121637514 4696069 1811428..1812510 1 NC_008769.1 ionic transporter integral membrane protein chaA 1812510 chaA 4696069 chaA Mycobacterium bovis BCG str. Pasteur 1173P2 ionic transporter integral membrane protein chaA YP_977737.1 1811428 D 410289 CDS YP_977738.1 121637515 4697511 complement(1812545..1813009) 1 NC_008769.1 peroxidoxin bcpB 1813009 bcpB 4697511 bcpB Mycobacterium bovis BCG str. Pasteur 1173P2 peroxidoxin bcpB YP_977738.1 1812545 R 410289 CDS YP_977739.1 121637516 4696505 1813150..1814700 1 NC_008769.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1814700 trpE 4696505 trpE Mycobacterium bovis BCG str. Pasteur 1173P2 anthranilate synthase component I YP_977739.1 1813150 D 410289 CDS YP_977740.1 121637517 4695827 1814690..1815397 1 NC_008769.1 hypothetical protein 1815397 4695827 BCG_1648 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977740.1 1814690 D 410289 CDS YP_977741.1 121637518 4697571 1815487..1816305 1 NC_008769.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase 1816305 trpC 4697571 trpC Mycobacterium bovis BCG str. Pasteur 1173P2 indole-3-glycerol-phosphate synthase YP_977741.1 1815487 D 410289 CDS YP_977742.1 121637519 4696871 1816374..1817606 1 NC_008769.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1817606 trpB 4696871 trpB Mycobacterium bovis BCG str. Pasteur 1173P2 tryptophan synthase subunit beta YP_977742.1 1816374 D 410289 CDS YP_977743.1 121637520 4696870 1817606..1818418 1 NC_008769.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1818418 trpA 4696870 trpA Mycobacterium bovis BCG str. Pasteur 1173P2 tryptophan synthase subunit alpha YP_977743.1 1817606 D 410289 CDS YP_977744.1 121637521 4696869 1818418..1819824 1 NC_008769.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1819824 lgt 4696869 lgt Mycobacterium bovis BCG str. Pasteur 1173P2 prolipoprotein diacylglyceryl transferase YP_977744.1 1818418 D 410289 CDS YP_977745.1 121637522 4697269 1820500..1820940 1 NC_008769.1 hypothetical protein 1820940 4697269 BCG_1653 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977745.1 1820500 D 410289 CDS YP_977746.1 121637523 4697061 1820930..1821328 1 NC_008769.1 hypothetical protein 1821328 4697061 BCG_1654 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977746.1 1820930 D 410289 CDS YP_977747.1 121637524 4695734 1821436..1822854 1 NC_008769.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1822854 pykA 4695734 pykA Mycobacterium bovis BCG str. Pasteur 1173P2 pyruvate kinase YP_977747.1 1821436 D 410289 CDS YP_977748.1 121637525 4696882 1822862..1823764 1 NC_008769.1 Differs from Rv1618 by 1aa, L121H; acyl-CoA thioesterase II tesB1 1823764 tesB1 4696882 tesB1 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA thioesterase II tesB1 YP_977748.1 1822862 D 410289 CDS YP_977749.1 121637526 4696850 1823822..1825276 1 NC_008769.1 hypothetical protein 1825276 4696850 BCG_1657 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977749.1 1823822 D 410289 CDS YP_977750.1 121637527 4696197 complement(1825210..1826940) 1 NC_008769.1 cytochrome assembly ABC transporter ATP-binding protein CydC 1826940 cydC 4696197 cydC Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome assembly ABC transporter ATP-binding protein CydC YP_977750.1 1825210 R 410289 CDS YP_977751.1 121637528 4696657 complement(1826937..1828520) 1 NC_008769.1 cytochrome assembly ABC transporter ATP-binding protein CydD 1828520 cydD 4696657 cydD Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome assembly ABC transporter ATP-binding protein CydD YP_977751.1 1826937 R 410289 CDS YP_977752.1 121637529 4698414 complement(1828607..1829647) 1 NC_008769.1 integral membrane cytochrome D ubiquinol oxidase (subunit II) cydB 1829647 cydB 4698414 cydB Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane cytochrome D ubiquinol oxidase (subunit II) cydB YP_977752.1 1828607 R 410289 CDS YP_977753.1 121637530 4697166 complement(1829677..1831134) 1 NC_008769.1 integral membrane cytochrome D ubiquinol oxidase (subunit I) cydA 1831134 cydA 4697166 cydA Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane cytochrome D ubiquinol oxidase (subunit I) cydA YP_977753.1 1829677 R 410289 CDS YP_977754.1 121637531 4696467 complement(1831245..1831832) 1 NC_008769.1 Differs from Rv1624c by 1aa, A178T; hypothetical protein 1831832 4696467 BCG_1662c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977754.1 1831245 R 410289 CDS YP_977755.1 121637532 4696392 complement(1831861..1833117) 1 NC_008769.1 membrane-anchored adenylyl cyclase cya 1833117 cya 4696392 cya Mycobacterium bovis BCG str. Pasteur 1173P2 membrane-anchored adenylyl cyclase cya YP_977755.1 1831861 R 410289 CDS YP_977756.1 121637533 4696750 1833427..1834044 1 NC_008769.1 two-component system transcriptional regulator 1834044 4696750 BCG_1664 Mycobacterium bovis BCG str. Pasteur 1173P2 two-component system transcriptional regulator YP_977756.1 1833427 D 410289 CDS YP_977757.1 121637534 4695610 complement(1834112..1835320) 1 NC_008769.1 lipid-transfer protein 1835320 4695610 BCG_1665c Mycobacterium bovis BCG str. Pasteur 1173P2 lipid-transfer protein YP_977757.1 1834112 R 410289 CDS YP_977758.1 121637535 4697102 complement(1835317..1835808) 1 NC_008769.1 Differs from Rv1628c and Mb1654c by 1aa, V93A; hypothetical protein 1835808 4697102 BCG_1666c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977758.1 1835317 R 410289 CDS YP_977759.1 121637536 4697474 1835912..1838626 1 NC_008769.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 1838626 polA 4697474 polA Mycobacterium bovis BCG str. Pasteur 1173P2 DNA polymerase I YP_977759.1 1835912 D 410289 CDS YP_977760.1 121637537 4696278 1838789..1840234 1 NC_008769.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1840234 rpsA 4696278 rpsA Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S1 YP_977760.1 1838789 D 410289 CDS YP_977761.1 121637538 4696378 1840260..1841483 1 NC_008769.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain; dephospho-CoA kinase/protein folding accessory domain-containing protein 1841483 coaE 4696378 coaE Mycobacterium bovis BCG str. Pasteur 1173P2 dephospho-CoA kinase/protein folding accessory domain-containing protein YP_977761.1 1840260 D 410289 CDS YP_977762.1 121637539 4698571 complement(1841634..1842077) 1 NC_008769.1 hypothetical protein 1842077 4698571 BCG_1670c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977762.1 1841634 R 410289 CDS YP_977763.1 121637540 4697613 1842322..1844418 1 NC_008769.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1844418 uvrB 4697613 uvrB Mycobacterium bovis BCG str. Pasteur 1173P2 excinuclease ABC subunit B YP_977763.1 1842322 D 410289 CDS YP_977764.1 121637541 4697750 1844415..1845830 1 NC_008769.1 Differs from Rv1634 by 2aa, Q13E, R198G, and from Mb1660 by 1aa, Q13E; drug efflux membrane protein 1845830 4697750 BCG_1672 Mycobacterium bovis BCG str. Pasteur 1173P2 drug efflux membrane protein YP_977764.1 1844415 D 410289 CDS YP_977765.1 121637542 4698447 complement(1845819..1847489) 1 NC_008769.1 hypothetical protein 1847489 4698447 BCG_1673c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977765.1 1845819 R 410289 CDS YP_977766.1 121637543 4696698 1847698..1848138 1 NC_008769.1 hypothetical protein 1848138 TB15.3 4696698 TB15.3 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977766.1 1847698 D 410289 CDS YP_977767.1 121637544 4697559 complement(1848145..1848939) 1 NC_008769.1 hypothetical protein 1848939 4697559 BCG_1675c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977767.1 1848145 R 410289 CDS YP_977768.1 121637545 4697612 1848988..1851906 1 NC_008769.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 1851906 uvrA 4697612 uvrA Mycobacterium bovis BCG str. Pasteur 1173P2 excinuclease ABC subunit A YP_977768.1 1848988 D 410289 CDS YP_977769.1 121637546 4697749 complement(1851963..1852220) 1 NC_008769.1 hypothetical protein 1852220 4697749 BCG_1677c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977769.1 1851963 R 410289 CDS YP_977770.1 121637547 4697124 complement(1852236..1853705) 1 NC_008769.1 hypothetical protein 1853705 4697124 BCG_1678c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977770.1 1852236 R 410289 CDS YP_977771.1 121637548 4695723 complement(1853764..1857282) 1 NC_008769.1 catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 1857282 lysS 4695723 lysS Mycobacterium bovis BCG str. Pasteur 1173P2 lysyl-tRNA synthetase YP_977771.1 1853764 R 410289 CDS YP_977772.1 121637549 4697179 1857519..1858124 1 NC_008769.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1858124 infC 4697179 infC Mycobacterium bovis BCG str. Pasteur 1173P2 translation initiation factor IF-3 YP_977772.1 1857519 D 410289 CDS YP_977773.1 121637550 4697075 1858174..1858368 1 NC_008769.1 50S ribosomal protein L35 1858368 rpmI 4697075 rpmI Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L35 YP_977773.1 1858174 D 410289 CDS YP_977774.1 121637551 4695800 1858430..1858819 1 NC_008769.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1858819 rplT 4695800 rplT Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L20 YP_977774.1 1858430 D 410289 CDS YP_977775.1 121637552 4695880 1858852..1859634 1 NC_008769.1 Differs from Rv1644 by 1aa, P232L; 23S rRNA methyltransferase tsnR 1859634 tsnR 4695880 tsnR Mycobacterium bovis BCG str. Pasteur 1173P2 23S rRNA methyltransferase tsnR YP_977775.1 1858852 D 410289 CDS YP_977776.1 121637553 4697090 complement(1859645..1860700) 1 NC_008769.1 hypothetical protein 1860700 4697090 BCG_1684c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977776.1 1859645 R 410289 CDS YP_977777.1 121637554 4697534 1861010..1861942 1 NC_008769.1 PE family protein 1861942 PE17 4697534 PE17 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_977777.1 1861010 D 410289 CDS YP_977778.1 121637555 4699007 1862020..1862970 1 NC_008769.1 Differs from Rv1647 by 1aa, P2A; hypothetical protein 1862970 4699007 BCG_1686 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977778.1 1862020 D 410289 CDS YP_977779.1 121637556 4697092 1862977..1863783 1 NC_008769.1 hypothetical protein 1863783 4697092 BCG_1687 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977779.1 1862977 D 410289 CDS YP_977780.1 121637557 4695647 1863979..1865004 1 NC_008769.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1865004 pheS 4695647 pheS Mycobacterium bovis BCG str. Pasteur 1173P2 phenylalanyl-tRNA synthetase subunit alpha YP_977780.1 1863979 D 410289 CDS YP_977781.1 121637558 4697583 1865004..1867499 1 NC_008769.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1867499 pheT 4697583 pheT Mycobacterium bovis BCG str. Pasteur 1173P2 phenylalanyl-tRNA synthetase subunit beta YP_977781.1 1865004 D 410289 CDS YP_977782.1 121637559 4697584 complement(1867593..1870649) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, an in-frame insertion of 21 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1018 aa versus 1011 aa). Differs from Rv1651c by insertion of 7aa at position 152 and by 1aa, V179A; PE-PGRS family protein 1870649 PE_PGRS30 4697584 PE_PGRS30 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977782.1 1867593 R 410289 CDS YP_977783.1 121637560 4696582 1870843..1871901 1 NC_008769.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 1871901 argC 4696582 argC Mycobacterium bovis BCG str. Pasteur 1173P2 N-acetyl-gamma-glutamyl-phosphate reductase YP_977783.1 1870843 D 410289 CDS YP_977784.1 121637561 4699129 1871898..1873112 1 NC_008769.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase 1873112 argJ 4699129 argJ Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional ornithine acetyltransferase/N-acetylglutamate synthase YP_977784.1 1871898 D 410289 CDS YP_977785.1 121637562 4696230 1873109..1873993 1 NC_008769.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 1873993 argB 4696230 argB Mycobacterium bovis BCG str. Pasteur 1173P2 acetylglutamate kinase YP_977785.1 1873109 D 410289 CDS YP_977786.1 121637563 4697018 1873990..1875192 1 NC_008769.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase 1875192 argD 4697018 argD Mycobacterium bovis BCG str. Pasteur 1173P2 acetylornithine aminotransferase YP_977786.1 1873990 D 410289 CDS YP_977787.1 121637564 4696357 1875189..1876112 1 NC_008769.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 1876112 argF 4696357 argF Mycobacterium bovis BCG str. Pasteur 1173P2 ornithine carbamoyltransferase YP_977787.1 1875189 D 410289 CDS YP_977788.1 121637565 4697195 1876109..1876621 1 NC_008769.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 1876621 argR 4697195 argR Mycobacterium bovis BCG str. Pasteur 1173P2 arginine repressor YP_977788.1 1876109 D 410289 CDS YP_977789.1 121637566 4696670 1876630..1877826 1 NC_008769.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 1877826 argG 4696670 argG Mycobacterium bovis BCG str. Pasteur 1173P2 argininosuccinate synthase YP_977789.1 1876630 D 410289 CDS YP_977790.1 121637567 4696651 1877906..1879318 1 NC_008769.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 1879318 argH 4696651 argH Mycobacterium bovis BCG str. Pasteur 1173P2 argininosuccinate lyase YP_977790.1 1877906 D 410289 CDS YP_977791.1 121637568 4695598 1879427..1880488 1 NC_008769.1 chalcone synthase pks10 1880488 pks10 4695598 pks10 Mycobacterium bovis BCG str. Pasteur 1173P2 chalcone synthase pks10 YP_977791.1 1879427 D 410289 CDS YP_977792.1 121637569 4696190 1880571..1886951 1 NC_008769.1 Differs from Rv1661 by 2aa, W670R, P1176S; polyketide synthase pks7 1886951 pks7 4696190 pks7 Mycobacterium bovis BCG str. Pasteur 1173P2 polyketide synthase pks7 YP_977792.1 1880571 D 410289 CDS YP_977793.1 121637570 4696579 1886971..1891776 1 NC_008769.1 Differs from Rv1662 by 6aa, Y78D, deletion of V692, V807A, G1260R, T1356A, C1468Y, and from Mb1690 by 1aa, deletion of V692; polyketide synthase 1891776 pks8 4696579 pks8 Mycobacterium bovis BCG str. Pasteur 1173P2 polyketide synthase YP_977793.1 1886971 D 410289 CDS YP_977794.1 121637571 4696580 1891776..1893284 1 NC_008769.1 polyketide synthase 1893284 pks17 4696580 pks17 Mycobacterium bovis BCG str. Pasteur 1173P2 polyketide synthase YP_977794.1 1891776 D 410289 CDS YP_977795.1 121637572 4698459 1893290..1896343 1 NC_008769.1 Differs from Rv1664 by 2aa, T36A, P350A; polyketide synthase pks9 1896343 pks9 4698459 pks9 Mycobacterium bovis BCG str. Pasteur 1173P2 polyketide synthase pks9 YP_977795.1 1893290 D 410289 CDS YP_977796.1 121637573 4695941 1896490..1897551 1 NC_008769.1 chalcone synthase pks11 1897551 pks11 4695941 pks11 Mycobacterium bovis BCG str. Pasteur 1173P2 chalcone synthase pks11 YP_977796.1 1896490 D 410289 CDS YP_977797.1 121637574 4696191 complement(1897534..1898826) 1 NC_008769.1 cytochrome P450 139 CYP139 1898826 cyp139 4696191 cyp139 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome P450 139 CYP139 YP_977797.1 1897534 R 410289 CDS YP_977798.1 121637575 4696228 complement(1898841..1900616) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1668c and Rv1667c exist as 2 genes with a small overlap between them. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 10 bp insertion (*-tcttgccgcg) leads to a single product; macrolide ABC transporter ATP-binding protein 1900616 4696228 BCG_1706c Mycobacterium bovis BCG str. Pasteur 1173P2 macrolide ABC transporter ATP-binding protein YP_977798.1 1898841 R 410289 CDS YP_977799.1 121637576 4696348 1900999..1901361 1 NC_008769.1 hypothetical protein 1901361 4696348 BCG_1707 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977799.1 1900999 D 410289 CDS YP_977800.1 121637577 4697136 1901394..1901741 1 NC_008769.1 hypothetical protein 1901741 4697136 BCG_1708 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977800.1 1901394 D 410289 CDS YP_977801.1 121637578 4697162 1901749..1902141 1 NC_008769.1 hypothetical protein 1902141 4697162 BCG_1709 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977801.1 1901749 D 410289 CDS YP_977802.1 121637579 4695573 complement(1902150..1903481) 1 NC_008769.1 integral membrane transport protein 1903481 4695573 BCG_1710c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane transport protein YP_977802.1 1902150 R 410289 CDS YP_977803.1 121637580 4697833 complement(1903574..1904506) 1 NC_008769.1 hypothetical protein 1904506 4697833 BCG_1711c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977803.1 1903574 R 410289 CDS YP_977804.1 121637581 4697546 complement(1904534..1905190) 1 NC_008769.1 transcriptional regulatory protein 1905190 4697546 BCG_1712c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977804.1 1904534 R 410289 CDS YP_977805.1 121637582 4697059 complement(1905515..1906249) 1 NC_008769.1 Differs from Rv1675c by 1aa, A59V; transcriptional regulatory protein 1906249 4697059 BCG_1713c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977805.1 1905515 R 410289 CDS YP_977806.1 121637583 4696685 1906321..1907025 1 NC_008769.1 hypothetical protein 1907025 4696685 BCG_1714 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977806.1 1906321 D 410289 CDS YP_977807.1 121637584 4696656 1907022..1907570 1 NC_008769.1 lipoprotein dsbF 1907570 dsbF 4696656 dsbF Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein dsbF YP_977807.1 1907022 D 410289 CDS YP_977808.1 121637585 4698466 1907671..1908573 1 NC_008769.1 hypothetical protein 1908573 4698466 BCG_1716 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977808.1 1907671 D 410289 CDS YP_977809.1 121637586 4696792 1908573..1909694 1 NC_008769.1 acyl-CoA dehydrogenase fadE16 1909694 fadE16 4696792 fadE16 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE16 YP_977809.1 1908573 D 410289 CDS YP_977810.1 121637587 4697443 1909703..1910527 1 NC_008769.1 Differs from Mb1707 by 1aa, A230G; hypothetical protein 1910527 4697443 BCG_1718 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977810.1 1909703 D 410289 CDS YP_977811.1 121637588 4697380 1910524..1911516 1 NC_008769.1 molybdopterin biosynthesis protein moeX 1911516 moeX 4697380 moeX Mycobacterium bovis BCG str. Pasteur 1173P2 molybdopterin biosynthesis protein moeX YP_977811.1 1910524 D 410289 CDS YP_977812.1 121637589 4697175 1911677..1912594 1 NC_008769.1 coiled-coil structural protein 1912594 4697175 BCG_1720 Mycobacterium bovis BCG str. Pasteur 1173P2 coiled-coil structural protein YP_977812.1 1911677 D 410289 CDS YP_977813.1 121637590 4695722 1912812..1915811 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1915811 4695722 BCG_1721 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_977813.1 1912812 D 410289 CDS YP_977814.1 121637591 4696263 1915804..1916028 1 NC_008769.1 hypothetical protein 1916028 4696263 BCG_1722 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977814.1 1915804 D 410289 CDS YP_977815.1 121637592 4696637 complement(1915994..1916617) 1 NC_008769.1 hypothetical protein 1916617 4696637 BCG_1723c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977815.1 1915994 R 410289 CDS YP_977816.1 121637593 4696543 complement(1916619..1917299) 1 NC_008769.1 Differs from Rv1686c by 1aa, F20V; integral membrane protein ABC transporter 1917299 4696543 BCG_1724c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein ABC transporter YP_977816.1 1916619 R 410289 CDS YP_977817.1 121637594 4695620 complement(1917371..1918138) 1 NC_008769.1 ABC transporter ATP-binding protein 1918138 4695620 BCG_1725c Mycobacterium bovis BCG str. Pasteur 1173P2 ABC transporter ATP-binding protein YP_977817.1 1917371 R 410289 CDS YP_977818.1 121637595 4695537 1918197..1918808 1 NC_008769.1 responsible for recognizing base lesions in the genome and initiating base excision DNA repair; 3-methyladenine DNA glycosylase 1918808 4695537 BCG_1726 Mycobacterium bovis BCG str. Pasteur 1173P2 3-methyladenine DNA glycosylase YP_977818.1 1918197 D 410289 CDS YP_977819.1 121637596 4697025 1918820..1920094 1 NC_008769.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1920094 tyrS 4697025 tyrS Mycobacterium bovis BCG str. Pasteur 1173P2 tyrosyl-tRNA synthetase YP_977819.1 1918820 D 410289 CDS YP_977820.1 121637597 4696864 1920745..1921128 1 NC_008769.1 In Mycobacterium bovis, a 2 bp insertion (*-ac) at the 5' end, leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG Pasteur(139 aa versus 127 aa); lipoprotein lprJ 1921128 lprJ 4696864 lprJ Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lprJ YP_977820.1 1920745 D 410289 CDS YP_977821.1 121637598 4698144 1921167..1921919 1 NC_008769.1 hypothetical protein 1921919 4698144 BCG_1729 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977821.1 1921167 D 410289 CDS YP_977822.1 121637599 4696476 1921916..1922977 1 NC_008769.1 phosphatase 1922977 4696476 BCG_1730 Mycobacterium bovis BCG str. Pasteur 1173P2 phosphatase YP_977822.1 1921916 D 410289 CDS YP_977823.1 121637600 4696134 1922974..1923150 1 NC_008769.1 hypothetical protein 1923150 4696134 BCG_1731 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977823.1 1922974 D 410289 CDS YP_977824.1 121637601 4695547 1923158..1923964 1 NC_008769.1 cytotoxin/hemolysin TlyA 1923964 tlyA 4695547 tlyA Mycobacterium bovis BCG str. Pasteur 1173P2 cytotoxin/hemolysin TlyA YP_977824.1 1923158 D 410289 CDS YP_977825.1 121637602 4696386 1923964..1924887 1 NC_008769.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1924887 ppnK 4696386 ppnK Mycobacterium bovis BCG str. Pasteur 1173P2 inorganic polyphosphate/ATP-NAD kinase YP_977825.1 1923964 D 410289 CDS YP_977826.1 121637603 4696368 1924901..1926664 1 NC_008769.1 DNA repair protein recN 1926664 recN 4696368 recN Mycobacterium bovis BCG str. Pasteur 1173P2 DNA repair protein recN YP_977826.1 1924901 D 410289 CDS YP_977827.1 121637604 4695839 1926760..1927941 1 NC_008769.1 hypothetical protein 1927941 4695839 BCG_1735 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977827.1 1926760 D 410289 CDS YP_977828.1 121637605 4696206 1927963..1928907 1 NC_008769.1 hypothetical protein 1928907 4696206 BCG_1736 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977828.1 1927963 D 410289 CDS YP_977829.1 121637606 4697320 1929047..1930807 1 NC_008769.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1930807 pyrG 4697320 pyrG Mycobacterium bovis BCG str. Pasteur 1173P2 CTP synthetase YP_977829.1 1929047 D 410289 CDS YP_977830.1 121637607 4697786 1930800..1931423 1 NC_008769.1 Differs from Mb1726 by 2aa, F43L, A202T; hypothetical protein 1931423 4697786 BCG_1738 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977830.1 1930800 D 410289 CDS YP_977831.1 121637608 4696629 1931420..1932355 1 NC_008769.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 1932355 xerD 4696629 xerD Mycobacterium bovis BCG str. Pasteur 1173P2 site-specific tyrosine recombinase XerD YP_977831.1 1931420 D 410289 CDS YP_977832.1 121637609 4696276 complement(1932429..1933793) 1 NC_008769.1 hypothetical protein 1933793 4696276 BCG_1740c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977832.1 1932429 R 410289 CDS YP_977833.1 121637610 4695640 complement(1934348..1934938) 1 NC_008769.1 Differs from Rv1703c and Mb1729c by 1aa, S48G; catechol-o-methyltransferase 1934938 4695640 BCG_1741c Mycobacterium bovis BCG str. Pasteur 1173P2 catechol-o-methyltransferase YP_977833.1 1934348 R 410289 CDS YP_977834.1 121637611 4698430 complement(1935003..1936673) 1 NC_008769.1 Differs from Rv1704c by 2aa, L93R, S122G, and from Mb1730c by 1aa, S122G; D-serine/alanine/glycine transporter protein cycA 1936673 cycA 4698430 cycA Mycobacterium bovis BCG str. Pasteur 1173P2 D-serine/alanine/glycine transporter protein cycA YP_977834.1 1935003 R 410289 CDS YP_977835.1 121637612 4695846 complement(1936714..1937871) 1 NC_008769.1 Differs from Rv1705c by 2aa, A2D, V313L, and from Mb1731c by 1aa, A2D; PPE family protein 1937871 PPE22 4695846 PPE22 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977835.1 1936714 R 410289 CDS YP_977836.1 121637613 4698628 complement(1937911..1939095) 1 NC_008769.1 PPE family protein 1939095 PPE23 4698628 PPE23 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977836.1 1937911 R 410289 CDS YP_977837.1 121637614 4698629 complement(1939699..1939866) 1 NC_008769.1 hypothetical protein 1939866 4698629 BCG_1745c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977837.1 1939699 R 410289 CDS YP_977838.1 121637615 4697322 1940099..1941559 1 NC_008769.1 Differs from Rv1707 by 1aa, Q438R; hypothetical protein 1941559 4697322 BCG_1746 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977838.1 1940099 D 410289 CDS YP_977839.1 121637616 4697165 1941577..1942533 1 NC_008769.1 Differs from Rv1708 by 1a,a T56A; initiation inhibitor protein 1942533 4697165 BCG_1747 Mycobacterium bovis BCG str. Pasteur 1173P2 initiation inhibitor protein YP_977839.1 1941577 D 410289 CDS YP_977840.1 121637617 4697121 1942530..1943366 1 NC_008769.1 hypothetical protein 1943366 4697121 BCG_1748 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977840.1 1942530 D 410289 CDS YP_977841.1 121637618 4696237 1943363..1944058 1 NC_008769.1 hypothetical protein 1944058 4696237 BCG_1749 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977841.1 1943363 D 410289 CDS YP_977842.1 121637619 4695692 1944055..1944819 1 NC_008769.1 hypothetical protein 1944819 4695692 BCG_1750 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977842.1 1944055 D 410289 CDS YP_977843.1 121637620 4697900 1944816..1945508 1 NC_008769.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1945508 cmk 4697900 cmk Mycobacterium bovis BCG str. Pasteur 1173P2 cytidylate kinase YP_977843.1 1944816 D 410289 CDS YP_977844.1 121637621 4698565 1945505..1946896 1 NC_008769.1 synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1946896 engA 4698565 engA Mycobacterium bovis BCG str. Pasteur 1173P2 GTP-binding protein EngA YP_977844.1 1945505 D 410289 CDS YP_977845.1 121637622 4697850 1947070..1947882 1 NC_008769.1 oxidoreductase 1947882 4697850 BCG_1753 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_977845.1 1947070 D 410289 CDS YP_977846.1 121637623 4697480 1947876..1948790 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur, Rv1715/fadB3 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) splits fadB3 into 2 parts, fadB3a and fadB3b; 3-hydroxybutyryl-CoA dehydrogenase 1948790 fadB3 4697480 fadB3 Mycobacterium bovis BCG str. Pasteur 1173P2 3-hydroxybutyryl-CoA dehydrogenase YP_977846.1 1947876 D 410289 CDS YP_977847.1 121637624 4698284 1948793..1949623 1 NC_008769.1 Differs from Rv1716 by 2aa, G178S, A276V; hypothetical protein 1949623 4698284 BCG_1755 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977847.1 1948793 D 410289 CDS YP_977848.1 121637625 4697632 1949623..1949973 1 NC_008769.1 hypothetical protein 1949973 4697632 BCG_1756 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977848.1 1949623 D 410289 CDS YP_977849.1 121637626 4695916 1950026..1950649 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, exists as a single gene. In Mycobacterium bovis AF2122/97 and Mycobacterium bovis BCG Pasteur, a single base deletion (c-*) leads to a shorter product with a different COOH terminus; hypothetical protein 1950649 4695916 BCG_1757 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977849.1 1950026 D 410289 CDS YP_977850.1 121637627 4697529 1950857..1951636 1 NC_008769.1 transcriptional regulatory protein 1951636 4697529 BCG_1758 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977850.1 1950857 D 410289 CDS YP_977851.1 121637628 4695948 complement(1952246..1952635) 1 NC_008769.1 hypothetical protein 1952635 4695948 BCG_1759c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977851.1 1952246 R 410289 CDS YP_977852.1 121637629 4698888 complement(1952632..1952859) 1 NC_008769.1 hypothetical protein 1952859 4698888 BCG_1760c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977852.1 1952632 R 410289 CDS YP_977853.1 121637630 4696735 1953077..1954561 1 NC_008769.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; biotin carboxylase-like protein 1954561 4696735 BCG_1761 Mycobacterium bovis BCG str. Pasteur 1173P2 biotin carboxylase-like protein YP_977853.1 1953077 D 410289 CDS YP_977854.1 121637631 4695642 1954558..1955805 1 NC_008769.1 hydrolase 1955805 4695642 BCG_1762 Mycobacterium bovis BCG str. Pasteur 1173P2 hydrolase YP_977854.1 1954558 D 410289 CDS YP_977855.1 121637632 4695535 complement(1955848..1956267) 1 NC_008769.1 hypothetical protein 1956267 4695535 BCG_1763c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977855.1 1955848 R 410289 CDS YP_977856.1 121637633 4698398 complement(1956257..1956967) 1 NC_008769.1 hypothetical protein 1956967 4698398 BCG_1764c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977856.1 1956257 R 410289 CDS YP_977857.1 121637634 4697417 1957068..1958453 1 NC_008769.1 Differs from Rv1726 by 1aa, Y326H, and from Mb1755 by 1aa, A61P; oxidoreductase 1958453 4697417 BCG_1765 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_977857.1 1957068 D 410289 CDS YP_977858.1 121637635 4695565 1958486..1959055 1 NC_008769.1 Differs from Rv1727 and Mb1756 by 1aa, D22E; hypothetical protein 1959055 4695565 BCG_1766 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977858.1 1958486 D 410289 CDS YP_977859.1 121637636 4697042 complement(1959080..1959850) 1 NC_008769.1 hypothetical protein 1959850 4697042 BCG_1767c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977859.1 1959080 R 410289 CDS YP_977860.1 121637637 4697646 complement(1959847..1960785) 1 NC_008769.1 hypothetical protein 1960785 4697646 BCG_1768c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977860.1 1959847 R 410289 CDS YP_977861.1 121637638 4695526 complement(1960851..1962404) 1 NC_008769.1 penicillin-binding protein 1962404 4695526 BCG_1769c Mycobacterium bovis BCG str. Pasteur 1173P2 penicillin-binding protein YP_977861.1 1960851 R 410289 CDS YP_977862.1 121637639 4697644 1962836..1964392 1 NC_008769.1 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinate-semialdehyde dehydrogenase 1964392 gabD2 4697644 gabD2 Mycobacterium bovis BCG str. Pasteur 1173P2 succinate-semialdehyde dehydrogenase YP_977862.1 1962836 D 410289 CDS YP_977863.1 121637640 4695549 complement(1964402..1964950) 1 NC_008769.1 hypothetical protein 1964950 4695549 BCG_1771c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977863.1 1964402 R 410289 CDS YP_977864.1 121637641 4697334 complement(1965014..1965646) 1 NC_008769.1 Differs from Rv1733c by 1aa, H68Q; hypothetical protein 1965646 4697334 BCG_1772c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977864.1 1965014 R 410289 CDS YP_977865.1 121637642 4695678 complement(1965933..1966175) 1 NC_008769.1 Differs from Mb1763c by 1aa, T79A; hypothetical protein 1966175 4695678 BCG_1773c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977865.1 1965933 R 410289 CDS YP_977866.1 121637643 4696857 complement(1966450..1966947) 1 NC_008769.1 hypothetical protein 1966947 4696857 BCG_1774c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977866.1 1966450 R 410289 CDS YP_977867.1 121637644 4697527 complement(1967387..1969345) 1 NC_008769.1 Diffesr from Rv1736c by 2aa, H53D, G77D; nitrate reductase NarX 1969345 narX 4697527 narX Mycobacterium bovis BCG str. Pasteur 1173P2 nitrate reductase NarX YP_977867.1 1967387 R 410289 CDS YP_977868.1 121637645 4697470 complement(1969342..1970529) 1 NC_008769.1 nitrate/nitrite transporter narK2 1970529 narK2 4697470 narK2 Mycobacterium bovis BCG str. Pasteur 1173P2 nitrate/nitrite transporter narK2 YP_977868.1 1969342 R 410289 CDS YP_977869.1 121637646 4697466 1970816..1971100 1 NC_008769.1 hypothetical protein 1971100 4697466 BCG_1777 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977869.1 1970816 D 410289 CDS YP_977870.1 121637647 4696672 complement(1971114..1972796) 1 NC_008769.1 Differs from Rv1739c by 1aa, L134R; sulfate-transport transmembrane protein ABC transporter 1972796 4696672 BCG_1778c Mycobacterium bovis BCG str. Pasteur 1173P2 sulfate-transport transmembrane protein ABC transporter YP_977870.1 1971114 R 410289 CDS YP_977871.1 121637648 4697742 1972864..1973076 1 NC_008769.1 hypothetical protein 1973076 4697742 BCG_1779 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977871.1 1972864 D 410289 CDS YP_977872.1 121637649 4697508 1973076..1973324 1 NC_008769.1 Differs from Rv1741 by 1aa, T67K; hypothetical protein 1973324 4697508 BCG_1780 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977872.1 1973076 D 410289 CDS YP_977873.1 121637650 4696554 1973405..1974070 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-c) leads to shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; hypothetical protein 1974070 4696554 BCG_1781 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977873.1 1973405 D 410289 CDS YP_977874.1 121637651 4695833 1974164..1975864 1 NC_008769.1 Differs from Mb1772 by 1aa, V56D; transmembrane serine/threonine-protein kinase E pknE 1975864 pknE 4695833 pknE Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane serine/threonine-protein kinase E pknE YP_977874.1 1974164 D 410289 CDS YP_977875.1 121637652 4696552 complement(1976149..1976550) 1 NC_008769.1 Differs from Rv1744c by 1aa, Q121R; hypothetical protein 1976550 4696552 BCG_1783c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977875.1 1976149 R 410289 CDS YP_977876.1 121637653 4697130 complement(1976621..1977151) 1 NC_008769.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 1977151 idi 4697130 idi Mycobacterium bovis BCG str. Pasteur 1173P2 isopentenyl-diphosphate delta-isomerase YP_977876.1 1976621 R 410289 CDS YP_977877.1 121637654 4699217 1977298..1978728 1 NC_008769.1 Differs from Rv1746 by 1aa, T325A; anchored-membrane serine/threonine-protein kinase pknF 1978728 pknF 4699217 pknF Mycobacterium bovis BCG str. Pasteur 1173P2 anchored-membrane serine/threonine-protein kinase pknF YP_977877.1 1977298 D 410289 CDS YP_977878.1 121637655 4696553 1978790..1981387 1 NC_008769.1 transmembrane ABC transporter ATP-binding protein 1981387 4696553 BCG_1786 Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane ABC transporter ATP-binding protein YP_977878.1 1978790 D 410289 CDS YP_977879.1 121637656 4695562 1981760..1982491 1 NC_008769.1 hypothetical protein 1982491 4695562 BCG_1787 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977879.1 1981760 D 410289 CDS YP_977880.1 121637657 4696719 complement(1982488..1983045) 1 NC_008769.1 integral membrane protein 1983045 4696719 BCG_1788c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_977880.1 1982488 R 410289 CDS YP_977881.1 121637658 4697760 complement(1983129..1984727) 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1984727 fadD1 4697760 fadD1 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_977881.1 1983129 R 410289 CDS YP_977882.1 121637659 4697776 1984781..1986163 1 NC_008769.1 Differs from Rv1751 by 2aa, T311M, L439V, and from Mb1780 by 1aa, T311M; hypothetical protein 1986163 4697776 BCG_1790 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977882.1 1984781 D 410289 CDS YP_977883.1 121637660 4696267 1986290..1986739 1 NC_008769.1 hypothetical protein 1986739 4696267 BCG_1791 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977883.1 1986290 D 410289 CDS YP_977884.1 121637661 4699275 complement(1986774..1989854) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, PPE24 differs in the 26 aa tandem repeat region, two copies less (in-frame deletion of 156 bp), and in the 25 aa repeat region, 2 and one more copies (in-frame insertion of 150bp and 75bp), respectively, compared to their homolog in Mycobacterium tuberculosis strain H37Rv; PPE family protein 1989854 PPE24 4699275 PPE24 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977884.1 1986774 R 410289 CDS YP_977885.1 121637662 4698630 complement(1990058..1991749) 1 NC_008769.1 Differs from Rv1754c and Mb1783c by 1aa, S546N; hypothetical protein 1991749 4698630 BCG_1793c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977885.1 1990058 R 410289 CDS YP_977886.1 121637663 4696567 complement(1991933..1993477) 1 NC_008769.1 Truncated by RvD2 deletion (6804bp) in Mycobacterium tuberculosis strain H37Rv; phospholipase C 4 plcD 1993477 plcD 4696567 plcD Mycobacterium bovis BCG str. Pasteur 1173P2 phospholipase C 4 plcD YP_977886.1 1991933 R 410289 CDS YP_977887.1 121637664 4695942 complement(1993606..1994790) 1 NC_008769.1 No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to the RvD2 region; hypothetical protein 1994790 4695942 BCG_1795c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977887.1 1993606 R 410289 CDS YP_977888.1 121637665 4695946 1994940..1996079 1 NC_008769.1 No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to RvD2 region; sulfite oxidase 1996079 4695946 BCG_1796 Mycobacterium bovis BCG str. Pasteur 1173P2 sulfite oxidase YP_977888.1 1994940 D 410289 CDS YP_977889.1 121637666 4696122 1996280..1999117 1 NC_008769.1 No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to RvD2 region; transmembrane transport protein mmpL14 1999117 mmpL14 4696122 mmpL14 Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane transport protein mmpL14 YP_977889.1 1996280 D 410289 CDS YP_977890.1 121637667 4697544 1999438..2000094 1 NC_008769.1 Belongs to the RvD2 region. In Mycobacterium tuberculosis strain H37Rv, Rv1758 is interrupted by IS6110 insertion element and the 5'-end is deleted; cutinase cut1 2000094 cut1 4697544 cut1 Mycobacterium bovis BCG str. Pasteur 1173P2 cutinase cut1 YP_977890.1 1999438 D 410289 CDS YP_977891.1 121637668 4697463 complement(2000361..2002769) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (c-*) splits wag22 into 2 parts, wag22a and wag22b. Differs from Mb1789c and Rv1759c by three deletions R129 replaced by AG, 5aa deletion at position 739 and 12aa deletion at position 777 making protein smaller (802 versus 820); PE-PGRS family protein 2002769 wag22b 4697463 wag22b Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977891.1 2000361 R 410289 CDS YP_977892.1 121637669 4697889 complement(2002766..2003050) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (c-*) splits wag22 into 2 parts, wag22a and wag22b; PE-PGRS family protein 2003050 wag22a 4697889 wag22a Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977892.1 2002766 R 410289 CDS YP_977893.1 121637670 4697888 2003626..2005155 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; Also differs from Rv1760 by 1aa, V219E; hypothetical protein 2005155 4697888 BCG_1801 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977893.1 2003626 D 410289 CDS YP_977894.1 121637671 4696647 complement(2005143..2005526) 1 NC_008769.1 hypothetical protein 2005526 4696647 BCG_1802c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977894.1 2005143 R 410289 CDS YP_977895.1 121637672 4695529 complement(2005526..2006314) 1 NC_008769.1 hypothetical protein 2006314 4695529 BCG_1803c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977895.1 2005526 R 410289 CDS YP_977896.1 121637673 4697899 complement(2006454..2006921) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv this region is occupied by IS6110 which interrupts the gene and appears to have deleted sequences downstream. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, there is an 848bp sequence that has replaced a 121bp sequence corresponding to H37Rv positions 1997332-1997452; hypothetical protein 2006921 4697899 BCG_1804c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977896.1 2006454 R 410289 CDS YP_977897.1 121637674 4697950 complement(2007019..2007171) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv this region is occupied by IS6110 which appears to have deleted sequences downstream. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, there is an 848bp sequence that has replaced a 121bp sequence corresponding to H37Rv positions 1997332-1997452; hypothetical protein 2007171 4697950 BCG_1805c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977897.1 2007019 R 410289 CDS YP_977898.1 121637675 4695607 complement(2007332..2008771) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, deletion of 9068 bp (region of difference RD14), compared to Mycobacterium tuberculosis H37Rv2 (position: 1998226..2007293) and Mycobacterium bovis AF2122/97 (position 1988666..1997751), removes genes Rv1765A-Rv1772 and merges truncated genes Rv1773c and Rv1765c; hypothetical protein 2008771 4695607 BCG_1806c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977898.1 2007332 R 410289 CDS YP_977899.1 121637676 4696474 2008837..2010177 1 NC_008769.1 oxidoreductase 2010177 4696474 BCG_1807 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_977899.1 2008837 D 410289 CDS YP_977900.1 121637677 4695511 2010177..2010995 1 NC_008769.1 hypothetical protein 2010995 4695511 BCG_1808 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977900.1 2010177 D 410289 CDS YP_977901.1 121637678 4696077 complement(2011000..2011560) 1 NC_008769.1 transcriptional regulatory protein 2011560 4696077 BCG_1809c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977901.1 2011000 R 410289 CDS YP_977902.1 121637679 4697618 2011661..2012965 1 NC_008769.1 Differs from Rv1777 by 1aa Q325H; cytochrome p450 144 CYP144 2012965 cyp144 4697618 cyp144 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome p450 144 CYP144 YP_977902.1 2011661 D 410289 CDS YP_977903.1 121637680 4696758 complement(2013086..2013535) 1 NC_008769.1 Differs from Rv1778c by 1aa T32R; hypothetical protein 2013535 4696758 BCG_1811c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977903.1 2013086 R 410289 CDS YP_977904.1 121637681 4696351 complement(2013691..2015484) 1 NC_008769.1 hypothetical protein 2015484 4696351 BCG_1812c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977904.1 2013691 R 410289 CDS YP_977905.1 121637682 4696603 2015704..2016267 1 NC_008769.1 hypothetical protein 2016267 4696603 BCG_1813 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977905.1 2015704 D 410289 CDS YP_977906.1 121637683 4695401 complement(2016307..2018481) 1 NC_008769.1 Differs from Rv1781c and Mb1810c by 1aa, T12A; 4-alpha-glucanotransferase malQ 2018481 malQ 4695401 malQ Mycobacterium bovis BCG str. Pasteur 1173P2 4-alpha-glucanotransferase malQ YP_977906.1 2016307 R 410289 CDS YP_977907.1 121637684 4698307 2018745..2020265 1 NC_008769.1 Differs from Rv1782 by 1aa H41R; hypothetical protein 2020265 4698307 BCG_1815 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977907.1 2018745 D 410289 CDS YP_977908.1 121637685 4697385 2020262..2024437 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1783 and Rv1784 exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base transversion (a-t) leads to a single product. Differs from Rv1783 and Mb1812 by 1aa, V692A, identical to Rv1784; hypothetical protein 2024437 4697385 BCG_1816 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977908.1 2020262 D 410289 CDS YP_977909.1 121637686 4697777 complement(2024452..2025633) 1 NC_008769.1 cytochrome P450 143 cyp143 2025633 cyp143 4697777 cyp143 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome P450 143 cyp143 YP_977909.1 2024452 R 410289 CDS YP_977910.1 121637687 4695419 2025833..2026036 1 NC_008769.1 ferredoxin 2026036 4695419 BCG_1818 Mycobacterium bovis BCG str. Pasteur 1173P2 ferredoxin YP_977910.1 2025833 D 410289 CDS YP_977911.1 121637688 4697046 2026306..2027400 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 8 bp to 5 bp substitution (agcccggt-ccggg), leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (364 aa versus 365 aa). Identical to Mb1815; PPE family protein 2027400 PPE25 4697046 PPE25 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977911.1 2026306 D 410289 CDS YP_977912.1 121637689 4698631 2027479..2027778 1 NC_008769.1 PE family protein 2027778 PE18 4698631 PE18 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_977912.1 2027479 D 410289 CDS YP_977913.1 121637690 4699008 2027792..2028973 1 NC_008769.1 Differs from Mb1817 by 1aa, S274A, identical to Rv1789; PPE family protein 2028973 PPE26 4699008 PPE26 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977913.1 2027792 D 410289 CDS YP_977914.1 121637691 4697681 2029427..2030479 1 NC_008769.1 Identical to Rv1790 differs from Mb1818 by 1aa, P190S; PPE family protein 2030479 PPE27 4697681 PPE27 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977914.1 2029427 D 410289 CDS YP_977915.1 121637692 4697682 2030906..2031205 1 NC_008769.1 PE family protein 2031205 PE19 4697682 PE19 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_977915.1 2030906 D 410289 CDS YP_977916.1 121637693 4699009 2031349..2031645 1 NC_008769.1 Differs from Rv1792 by 1aa Q48M; hypothetical protein 2031645 esxM 4699009 esxM Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977916.1 2031349 D 410289 CDS YP_977917.1 121637694 4695501 2031696..2031980 1 NC_008769.1 ESAT-6 like protein 5 2031980 esxN 4695501 esxN Mycobacterium bovis BCG str. Pasteur 1173P2 ESAT-6 like protein 5 YP_977917.1 2031696 D 410289 CDS YP_977918.1 121637695 4698771 2032068..2032970 1 NC_008769.1 hypothetical protein 2032970 4698771 BCG_1826 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977918.1 2032068 D 410289 CDS YP_977919.1 121637696 4697393 2033242..2034753 1 NC_008769.1 Differs from Mb1823 and Rv1795 by 1aa, T256A and D261G, respectively; hypothetical protein 2034753 4697393 BCG_1827 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977919.1 2033242 D 410289 CDS YP_977920.1 121637697 4696743 2034731..2036488 1 NC_008769.1 protease 2036488 4696743 BCG_1828 Mycobacterium bovis BCG str. Pasteur 1173P2 protease YP_977920.1 2034731 D 410289 CDS YP_977921.1 121637698 4697839 2036485..2037705 1 NC_008769.1 hypothetical protein 2037705 4697839 BCG_1829 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977921.1 2036485 D 410289 CDS YP_977922.1 121637699 4695994 2037702..2039534 1 NC_008769.1 hypothetical protein 2039534 4695994 BCG_1830 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977922.1 2037702 D 410289 CDS YP_977923.1 121637700 4696649 2040161..2040352 1 NC_008769.1 lipoprotein lppT 2040352 lppT 4696649 lppT Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppT YP_977923.1 2040161 D 410289 CDS YP_977924.1 121637701 4698577 2040455..2042422 1 NC_008769.1 Differs from Rv1800 by 3aa, W144C, V253F, V432I, and from Mb1828 by 1aa,V432I; PPE family protein 2042422 PPE28 4698577 PPE28 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977924.1 2040455 D 410289 CDS YP_977925.1 121637702 4697683 2043003..2044274 1 NC_008769.1 PPE family protein 2044274 PPE29 4697683 PPE29 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977925.1 2043003 D 410289 CDS YP_977926.1 121637703 4697684 2044386..2045777 1 NC_008769.1 PPE family protein 2045777 PPE30 4697684 PPE30 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977926.1 2044386 D 410289 CDS YP_977927.1 121637704 4697875 complement(2045925..2047547) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS32 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base transition (c-t) splits PE_PGRS32 into 2 parts, PE_PGRS32a and PE_PGRS32b; PE-PGRS family protein 2047547 PE_PGRS32b 4697875 PE_PGRS32b Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977927.1 2045925 R 410289 CDS YP_977928.1 121637705 4696584 complement(2047581..2047844) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS32 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base transition (c-t) splits PE_PGRS32 into 2 parts, PE_PGRS32a and PE_PGRS32b; PE-PGRS family protein 2047844 PE_PGRS32a 4696584 PE_PGRS32a Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977928.1 2047581 R 410289 CDS YP_977929.1 121637706 4696583 complement(2048025..2048351) 1 NC_008769.1 hypothetical protein 2048351 4696583 BCG_1837c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977929.1 2048025 R 410289 CDS YP_977930.1 121637707 4697893 complement(2048689..2049036) 1 NC_008769.1 hypothetical protein 2049036 4697893 BCG_1838c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977930.1 2048689 R 410289 CDS YP_977931.1 121637708 4697481 2049074..2049373 1 NC_008769.1 PE family protein 2049373 PE20 4697481 PE20 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_977931.1 2049074 D 410289 CDS YP_977932.1 121637709 4699377 2049400..2050599 1 NC_008769.1 Differs from Rv1807 by 2aa, S223F, L234V. Identical to Mb1836; PPE family protein 2050599 PPE31 4699377 PPE31 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977932.1 2049400 D 410289 CDS YP_977933.1 121637710 4697876 2050923..2052152 1 NC_008769.1 Differs from Rv1808 by 1aa, A301G; PPE family protein 2052152 PPE32 4697876 PPE32 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977933.1 2050923 D 410289 CDS YP_977934.1 121637711 4697877 2052284..2052847 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PPE33 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base transition (c-t) splits PPE33 into 2 parts, PPE33a and PPE33b; PPE family protein 2052847 PPE33a 4697877 PPE33a Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_977934.1 2052284 D 410289 CDS YP_977935.1 121637712 4697879 2053935..2054291 1 NC_008769.1 hypothetical protein 2054291 4697879 BCG_1844 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977935.1 2053935 D 410289 CDS YP_977936.1 121637713 4697405 2054445..2055149 1 NC_008769.1 Mg2+ transporter 2055149 4697405 BCG_1845 Mycobacterium bovis BCG str. Pasteur 1173P2 Mg2+ transporter YP_977936.1 2054445 D 410289 CDS YP_977937.1 121637714 4696226 complement(2055159..2056361) 1 NC_008769.1 Differs from Rv1812c by 1aa, P30L; dehydrogenase 2056361 4696226 BCG_1846c Mycobacterium bovis BCG str. Pasteur 1173P2 dehydrogenase YP_977937.1 2055159 R 410289 CDS YP_977938.1 121637715 4696658 complement(2056683..2057114) 1 NC_008769.1 hypothetical protein 2057114 4696658 BCG_1847c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977938.1 2056683 R 410289 CDS YP_977939.1 121637716 4695700 2057523..2058425 1 NC_008769.1 membrane-bound C-5 sterol desaturase erg3 2058425 erg3 4695700 erg3 Mycobacterium bovis BCG str. Pasteur 1173P2 membrane-bound C-5 sterol desaturase erg3 YP_977939.1 2057523 D 410289 CDS YP_977940.1 121637717 4698439 2058530..2059195 1 NC_008769.1 Differs from Rv1815 by 1aa, F83I; hypothetical protein 2059195 4698439 BCG_1849 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977940.1 2058530 D 410289 CDS YP_977941.1 121637718 4695524 2059258..2059962 1 NC_008769.1 transcriptional regulatory protein 2059962 4695524 BCG_1850 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977941.1 2059258 D 410289 CDS YP_977943.1 121637720 4696086 2060597..2062060 1 NC_008769.1 hypothetical protein 2062060 4696086 BCG_1852 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977943.1 2060597 D 410289 CDS YP_977944.1 121637721 4697565 complement(2062180..2063685) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 9 bp insertion (*-gccgccggc), leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (501 aa versus 498 aa). Differs from Rv1818c by 4aa, S233G, and deletion of 3aa near C-terminus. Identical to Mb1849c; PE-PGRS family protein 2063685 PE_PGRS33 4697565 PE_PGRS33 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977944.1 2062180 R 410289 CDS YP_977945.1 121637722 4696585 complement(2063820..2065739) 1 NC_008769.1 Differs from Rv1819c by 1aa, V603I; drugs-transport transmembrane ATP-binding protein ABC transporter 2065739 4696585 BCG_1854c Mycobacterium bovis BCG str. Pasteur 1173P2 drugs-transport transmembrane ATP-binding protein ABC transporter YP_977945.1 2063820 R 410289 CDS YP_977946.1 121637723 4696074 2065810..2067453 1 NC_008769.1 hypothetical protein 2067453 ilvG 4696074 ilvG Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977946.1 2065810 D 410289 CDS YP_977947.1 121637724 4698973 2067468..2069894 1 NC_008769.1 SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 2069894 secA2 4698973 secA2 Mycobacterium bovis BCG str. Pasteur 1173P2 preprotein translocase subunit SecA YP_977947.1 2067468 D 410289 CDS YP_977948.1 121637725 4697705 2070091..2070720 1 NC_008769.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase pgsA2 2070720 pgsA2 4697705 pgsA2 Mycobacterium bovis BCG str. Pasteur 1173P2 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase pgsA2 YP_977948.1 2070091 D 410289 CDS YP_977949.1 121637726 4698857 2070713..2071636 1 NC_008769.1 hypothetical protein 2071636 4698857 BCG_1858 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977949.1 2070713 D 410289 CDS YP_977950.1 121637727 4696546 2071665..2072030 1 NC_008769.1 hypothetical protein 2072030 4696546 BCG_1859 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977950.1 2071665 D 410289 CDS YP_977951.1 121637728 4696437 2072047..2072925 1 NC_008769.1 hypothetical protein 2072925 4696437 BCG_1860 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977951.1 2072047 D 410289 CDS YP_977952.1 121637729 4697131 2072963..2073367 1 NC_008769.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 2073367 gcvH 4697131 gcvH Mycobacterium bovis BCG str. Pasteur 1173P2 glycine cleavage system protein H YP_977952.1 2072963 D 410289 CDS YP_977953.1 121637730 4696532 2073607..2074095 1 NC_008769.1 hypothetical protein 2074095 cfp17 4696532 cfp17 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977953.1 2073607 D 410289 CDS YP_977954.1 121637731 4698290 2074092..2074835 1 NC_008769.1 hypothetical protein 2074835 4698290 BCG_1863 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977954.1 2074092 D 410289 CDS YP_977955.1 121637732 4695409 2074954..2075448 1 NC_008769.1 Differs from Rv1829 by 1aa R93C; hypothetical protein 2075448 4695409 BCG_1864 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977955.1 2074954 D 410289 CDS YP_977956.1 121637733 4696710 2075796..2076473 1 NC_008769.1 hypothetical protein 2076473 4696710 BCG_1865 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977956.1 2075796 D 410289 CDS YP_977957.1 121637734 4695609 2076526..2076783 1 NC_008769.1 hypothetical protein 2076783 4695609 BCG_1866 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977957.1 2076526 D 410289 CDS YP_977958.1 121637735 4696466 2076832..2079657 1 NC_008769.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 2079657 gcvB 4696466 gcvB Mycobacterium bovis BCG str. Pasteur 1173P2 glycine dehydrogenase YP_977958.1 2076832 D 410289 CDS YP_977959.1 121637736 4696531 complement(2079884..2080744) 1 NC_008769.1 haloalkane dehalogenase 2080744 4696531 BCG_1868c Mycobacterium bovis BCG str. Pasteur 1173P2 haloalkane dehalogenase YP_977959.1 2079884 R 410289 CDS YP_977960.1 121637737 4696841 2080785..2081651 1 NC_008769.1 Differs from Mb1865 by 1aa, V272A; hydrolase 2081651 4696841 BCG_1869 Mycobacterium bovis BCG str. Pasteur 1173P2 hydrolase YP_977960.1 2080785 D 410289 CDS YP_977961.1 121637738 4697356 complement(2081656..2083542) 1 NC_008769.1 hypothetical protein 2083542 4697356 BCG_1870c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977961.1 2081656 R 410289 CDS YP_977962.1 121637739 4697019 complement(2083558..2085591) 1 NC_008769.1 Differs from Rv1836c by 2aa, C137R, H591R; hypothetical protein 2085591 4697019 BCG_1871c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977962.1 2083558 R 410289 CDS YP_977963.1 121637740 4696985 complement(2085711..2087936) 1 NC_008769.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 2087936 glcB 4696985 glcB Mycobacterium bovis BCG str. Pasteur 1173P2 malate synthase G YP_977963.1 2085711 R 410289 CDS YP_977964.1 121637741 4697398 complement(2088212..2088607) 1 NC_008769.1 hypothetical protein 2088607 4697398 BCG_1873c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977964.1 2088212 R 410289 CDS YP_977965.1 121637742 4696248 complement(2088604..2088867) 1 NC_008769.1 hypothetical protein 2088867 4696248 BCG_1874c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977965.1 2088604 R 410289 CDS YP_977966.1 121637743 4698705 complement(2089654..2090472) 1 NC_008769.1 In Mycobacterium bovis, an in-frame deletion of 147 bp leads to a shorter protein compared to its homolog in Mycobacterium tuberculosis strain H37Rv (466 aa versus 518 aa). In Mycobacterium bovis BCG Pasteur a deletion of 1bp, splits PPE34 into 2 parts, PPE34a and PPE34b; PE-PGRS family protein 2090472 PE_PGRS34a 4698705 PE_PGRS34a Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_977966.1 2089654 R 410289 CDS YP_977967.1 121637744 4696586 complement(2090635..2091684) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 12 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (349 aa versus 345 aa); hypothetical protein 2091684 4696586 BCG_1877c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977967.1 2090635 R 410289 CDS YP_977968.1 121637745 4697024 complement(2091684..2093051) 1 NC_008769.1 Differs from Rv1842c by 1aa, S437L; hypothetical protein 2093051 4697024 BCG_1878c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977968.1 2091684 R 410289 CDS YP_977969.1 121637746 4696097 complement(2093225..2094664) 1 NC_008769.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 2094664 guaB1 4696097 guaB1 Mycobacterium bovis BCG str. Pasteur 1173P2 inosine 5-monophosphate dehydrogenase YP_977969.1 2093225 R 410289 CDS YP_977970.1 121637747 4697815 complement(2094030..2096087) 1 NC_008769.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2096087 gnd1 4697815 gnd1 Mycobacterium bovis BCG str. Pasteur 1173P2 6-phosphogluconate dehydrogenase YP_977970.1 2094030 R 410289 CDS YP_977971.1 121637748 4697622 complement(2096177..2097127) 1 NC_008769.1 Differs from Rv1845c and Mb1876c by 1aa, A222V; hypothetical protein 2097127 4697622 BCG_1881c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977971.1 2096177 R 410289 CDS YP_977972.1 121637749 4697281 complement(2097142..2097558) 1 NC_008769.1 Differs from Rv1846c by 1aa, Y92D; transcriptional regulatory protein 2097558 4697281 BCG_1882c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_977972.1 2097142 R 410289 CDS YP_977973.1 121637750 4696981 2097836..2098258 1 NC_008769.1 Differs from Rv1847 by 1aa, L90V; hypothetical protein 2098258 4696981 BCG_1883 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977973.1 2097836 D 410289 CDS YP_977974.1 121637751 4697952 2098307..2098609 1 NC_008769.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 2098609 ureA 4697952 ureA Mycobacterium bovis BCG str. Pasteur 1173P2 urease subunit gamma YP_977974.1 2098307 D 410289 CDS YP_977975.1 121637752 4696503 2098606..2098920 1 NC_008769.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); urease subunit beta 2098920 ureB 4696503 ureB Mycobacterium bovis BCG str. Pasteur 1173P2 urease subunit beta YP_977975.1 2098606 D 410289 CDS YP_977976.1 121637753 4696504 2098920..2100653 1 NC_008769.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 2100653 ureC 4696504 ureC Mycobacterium bovis BCG str. Pasteur 1173P2 urease subunit alpha YP_977976.1 2098920 D 410289 CDS YP_977977.1 121637754 4695765 2100653..2101288 1 NC_008769.1 Differs from Rv1851 by 1aa, L34V; urease accessory protein uref 2101288 ureF 4695765 ureF Mycobacterium bovis BCG str. Pasteur 1173P2 urease accessory protein uref YP_977977.1 2100653 D 410289 CDS YP_977978.1 121637755 4695767 2101299..2101973 1 NC_008769.1 urease accessory protein ureG 2101973 ureG 4695767 ureG Mycobacterium bovis BCG str. Pasteur 1173P2 urease accessory protein ureG YP_977978.1 2101299 D 410289 CDS YP_977979.1 121637756 4695768 2101981..2102607 1 NC_008769.1 urease accessory protein ureD 2102607 ureD 4695768 ureD Mycobacterium bovis BCG str. Pasteur 1173P2 urease accessory protein ureD YP_977979.1 2101981 D 410289 CDS YP_977980.1 121637757 4695766 complement(2102610..2104001) 1 NC_008769.1 Differs from Rv1854c by 1aa, R313G, and Mb1885c by 2aa, R284W, R313G; NADH dehydrogenase ndh 2104001 ndh 4695766 ndh Mycobacterium bovis BCG str. Pasteur 1173P2 NADH dehydrogenase ndh YP_977980.1 2102610 R 410289 CDS YP_977981.1 121637758 4696137 complement(2104142..2105065) 1 NC_008769.1 oxidoreductase 2105065 4696137 BCG_1891c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_977981.1 2104142 R 410289 CDS YP_977982.1 121637759 4696465 complement(2105104..2105781) 1 NC_008769.1 Differs from Rv1856c by 1aa, H185R; short chain dehydrogenase 2105781 4696465 BCG_1892c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_977982.1 2105104 R 410289 CDS YP_977983.1 121637760 4695448 2105943..2106728 1 NC_008769.1 molybdate-binding lipoprotein modA 2106728 modA 4695448 modA Mycobacterium bovis BCG str. Pasteur 1173P2 molybdate-binding lipoprotein modA YP_977983.1 2105943 D 410289 CDS YP_977984.1 121637761 4695567 2106731..2107525 1 NC_008769.1 molbdenum-transport integral membrane protein ABC transporter modB 2107525 modB 4695567 modB Mycobacterium bovis BCG str. Pasteur 1173P2 molbdenum-transport integral membrane protein ABC transporter modB YP_977984.1 2106731 D 410289 CDS YP_977985.1 121637762 4695568 2107532..2108641 1 NC_008769.1 Differs from Rv1859 by 1aa, M313T; molybdenum-transport ATP-binding protein ABC transporter modC 2108641 modC 4695568 modC Mycobacterium bovis BCG str. Pasteur 1173P2 molybdenum-transport ATP-binding protein ABC transporter modC YP_977985.1 2107532 D 410289 CDS YP_977986.1 121637763 4695569 2108694..2109671 1 NC_008769.1 Differs from Rv1860 by 1aa, L136F; hypothetical protein 2109671 apa 4695569 apa Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977986.1 2108694 D 410289 CDS YP_977987.1 121637764 4695898 2110123..2110428 1 NC_008769.1 hypothetical protein 2110428 4695898 BCG_1897 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977987.1 2110123 D 410289 CDS YP_977988.1 121637765 4695866 2110503..2111543 1 NC_008769.1 alcohol dehydrogenase adhA 2111543 adhA 4695866 adhA Mycobacterium bovis BCG str. Pasteur 1173P2 alcohol dehydrogenase adhA YP_977988.1 2110503 D 410289 CDS YP_977989.1 121637766 4697831 complement(2111550..2112320) 1 NC_008769.1 integral membrane protein 2112320 4697831 BCG_1899c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_977989.1 2111550 R 410289 CDS YP_977990.1 121637767 4696485 complement(2112313..2113068) 1 NC_008769.1 hypothetical protein 2113068 4696485 BCG_1900c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977990.1 2112313 R 410289 CDS YP_977991.1 121637768 4697312 complement(2113065..2113925) 1 NC_008769.1 short chain dehydrogenase 2113925 4697312 BCG_1901c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_977991.1 2113065 R 410289 CDS YP_977992.1 121637769 4697386 2114099..2116435 1 NC_008769.1 Differs from Rv1866 by 1aa, Q17E; hypothetical protein 2116435 4697386 BCG_1902 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977992.1 2114099 D 410289 CDS YP_977993.1 121637770 4697954 2116723..2118207 1 NC_008769.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 2118207 4697954 BCG_1903 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-CoA acetyltransferase YP_977993.1 2116723 D 410289 CDS YP_977994.1 121637771 4697956 2118306..2120405 1 NC_008769.1 Differs from Rv1868 and Mb1899 by 1aa, G621D; hypothetical protein 2120405 4697956 BCG_1904 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977994.1 2118306 D 410289 CDS YP_977995.1 121637772 4695597 complement(2120419..2121654) 1 NC_008769.1 Differs from Mb1900c and Rv1869c by 1aa, P4S; reductase 2121654 4695597 BCG_1905c Mycobacterium bovis BCG str. Pasteur 1173P2 reductase YP_977995.1 2120419 R 410289 CDS YP_977996.1 121637773 4696353 complement(2121721..2122389) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base transversion (t-a) and a single base transition (c-t) lead to a slightly longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (222 aa versus 211 aa); hypothetical protein 2122389 4696353 BCG_1906c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977996.1 2121721 R 410289 CDS YP_977997.1 121637774 4696513 complement(2122454..2122843) 1 NC_008769.1 hypothetical protein 2122843 4696513 BCG_1907c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977997.1 2122454 R 410289 CDS YP_977998.1 121637775 4696310 complement(2122866..2124110) 1 NC_008769.1 Differs from Rv1872c by 2aa, A59G, A176V; L-lactate dehydrogenase (cytochrome) lldD2 2124110 lldD2 4696310 lldD2 Mycobacterium bovis BCG str. Pasteur 1173P2 L-lactate dehydrogenase (cytochrome) lldD2 YP_977998.1 2122866 R 410289 CDS YP_977999.1 121637776 4695786 2124133..2124570 1 NC_008769.1 Differs from Mb1904 by 1aa, D102N; hypothetical protein 2124570 4695786 BCG_1909 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_977999.1 2124133 D 410289 CDS YP_978000.1 121637777 4697473 2124643..2125329 1 NC_008769.1 hypothetical protein 2125329 4697473 BCG_1910 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978000.1 2124643 D 410289 CDS YP_978001.1 121637778 4695382 2125340..2125783 1 NC_008769.1 hypothetical protein 2125783 4695382 BCG_1911 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978001.1 2125340 D 410289 CDS YP_978002.1 121637779 4695595 2126299..2126778 1 NC_008769.1 bacterioferritin bfrA 2126778 bfrA 4695595 bfrA Mycobacterium bovis BCG str. Pasteur 1173P2 bacterioferritin bfrA YP_978002.1 2126299 D 410289 CDS YP_978003.1 121637780 4696093 2126863..2128398 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-c), splits Rv1877 into 2 parts; integral membrane protein 2128398 4696093 BCG_1913 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_978003.1 2126863 D 410289 CDS YP_978004.1 121637781 4697828 2127713..2128927 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-c), splits Rv1877 into 2 parts; integral membrane protein 2128927 4697828 BCG_1914 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_978004.1 2127713 D 410289 CDS YP_978005.1 121637782 4696544 2128982..2130334 1 NC_008769.1 Identical to Rv1878, differs from Mb1910 by 1aa, A275T; glutamine synthetase glnA3 2130334 glnA3 4696544 glnA3 Mycobacterium bovis BCG str. Pasteur 1173P2 glutamine synthetase glnA3 YP_978005.1 2128982 D 410289 CDS YP_978006.1 121637783 4696211 2130337..2131473 1 NC_008769.1 hypothetical protein 2131473 4696211 BCG_1916 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978006.1 2130337 D 410289 CDS YP_978007.1 121637784 4695645 complement(2131501..2132817) 1 NC_008769.1 cytochrome p450 140 CYP140 2132817 cyp140 4695645 cyp140 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome p450 140 CYP140 YP_978007.1 2131501 R 410289 CDS YP_978008.1 121637785 4696037 complement(2132867..2133289) 1 NC_008769.1 lipoprotein lppE 2133289 lppE 4696037 lppE Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppE YP_978008.1 2132867 R 410289 CDS YP_978009.1 121637786 4696494 complement(2133330..2134163) 1 NC_008769.1 short chain dehydrogenase 2134163 4696494 BCG_1919c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_978009.1 2133330 R 410289 CDS YP_978010.1 121637787 4696723 complement(2134191..2134667) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 15 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (158 aa versus 153 aa); hypothetical protein 2134667 4696723 BCG_1920c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978010.1 2134191 R 410289 CDS YP_978011.1 121637788 4697500 complement(2134706..2135236) 1 NC_008769.1 resuscitation-promoting factor rpfC 2135236 rpfC 4697500 rpfC Mycobacterium bovis BCG str. Pasteur 1173P2 resuscitation-promoting factor rpfC YP_978011.1 2134706 R 410289 CDS YP_978012.1 121637789 4697714 complement(2135248..2135847) 1 NC_008769.1 catalyzes the interconversion of chorismate to prephenate; chorismate mutase 2135847 4697714 BCG_1922c Mycobacterium bovis BCG str. Pasteur 1173P2 chorismate mutase YP_978012.1 2135248 R 410289 CDS YP_978013.1 121637790 4698323 complement(2135865..2136842) 1 NC_008769.1 Differs from Rv1886c and Mb1918c by 1aa, L140F; hypothetical protein 2136842 fbpB 4698323 fbpB Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978013.1 2135865 R 410289 CDS YP_978014.1 121637791 4696565 2137233..2138375 1 NC_008769.1 Differs from Rv1887 and Mb1919 by 1aa, C121Y; hypothetical protein 2138375 4696565 BCG_1924 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978014.1 2137233 D 410289 CDS YP_978015.1 121637792 4697595 complement(2138345..2139064) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 10 bp insertion (*-tccgatcacc) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv (239 aa versus 186 aa); hypothetical protein 2139064 4697595 BCG_1925c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978015.1 2138345 R 410289 CDS YP_978016.1 121637793 4697826 complement(2139429..2139602) 1 NC_008769.1 hypothetical protein 2139602 4697826 BCG_1926c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978016.1 2139429 R 410289 CDS YP_978017.1 121637794 4695819 complement(2139646..2140002) 1 NC_008769.1 hypothetical protein 2140002 4695819 BCG_1927c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978017.1 2139646 R 410289 CDS YP_978018.1 121637795 4697783 complement(2140061..2140672) 1 NC_008769.1 hypothetical protein 2140672 4697783 BCG_1928c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978018.1 2140061 R 410289 CDS YP_978019.1 121637796 4695847 2140726..2141133 1 NC_008769.1 hypothetical protein 2141133 4695847 BCG_1929 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978019.1 2140726 D 410289 CDS YP_978020.1 121637797 4697779 2141150..2141461 1 NC_008769.1 hypothetical protein 2141461 4697779 BCG_1930 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978020.1 2141150 D 410289 CDS YP_978021.1 121637798 4695933 2141471..2141689 1 NC_008769.1 hypothetical protein 2141689 4695933 BCG_1931 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978021.1 2141471 D 410289 CDS YP_978022.1 121637799 4695455 complement(2141724..2142854) 1 NC_008769.1 hypothetical protein 2142854 4695455 BCG_1932c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978022.1 2141724 R 410289 CDS YP_978023.1 121637800 4697389 2143506..2143829 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1895 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, two frameshifts due to a single base deletion (a-*) and a single base insertion (*-t), consecutively, splits Rv1895 into 2 main parts; dehydrogenase 2143829 4697389 BCG_1933 Mycobacterium bovis BCG str. Pasteur 1173P2 dehydrogenase YP_978023.1 2143506 D 410289 CDS YP_978024.1 121637801 4697836 2143826..2144530 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv1895 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, two frameshifts due to a single base deletion (a-*) and a single base insertion (*-t), consecutively, splits Rv1895 into 2 main parts, Mb1928 and Mb1929; dehydrogenase 2144530 4697836 BCG_1934 Mycobacterium bovis BCG str. Pasteur 1173P2 dehydrogenase YP_978024.1 2143826 D 410289 CDS YP_978025.1 121637802 4697703 complement(2144520..2145431) 1 NC_008769.1 hypothetical protein 2145431 4697703 BCG_1935c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978025.1 2144520 R 410289 CDS YP_978026.1 121637803 4698364 complement(2145436..2145867) 1 NC_008769.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 2145867 4698364 BCG_1936c Mycobacterium bovis BCG str. Pasteur 1173P2 D-tyrosyl-tRNA(Tyr) deacylase YP_978026.1 2145436 R 410289 CDS YP_978027.1 121637804 4696540 2145925..2146233 1 NC_008769.1 hypothetical protein 2146233 4696540 BCG_1937 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978027.1 2145925 D 410289 CDS YP_978028.1 121637805 4697516 complement(2146199..2147275) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (358 aa versus 343 aa); lipoprotein lppD 2147275 lppD 4697516 lppD Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppD YP_978028.1 2146199 R 410289 CDS YP_978029.1 121637806 4699202 complement(2147275..2148663) 1 NC_008769.1 Differs from Rv1900c and Mb1935c by 1aa, M204I and R170Q, respectively; lignin peroxidase lipJ 2148663 lipJ 4699202 lipJ Mycobacterium bovis BCG str. Pasteur 1173P2 lignin peroxidase lipJ YP_978029.1 2147275 R 410289 CDS YP_978030.1 121637807 4698632 2148692..2149984 1 NC_008769.1 competence damage-inducible protein A 2149984 cinA 4698632 cinA Mycobacterium bovis BCG str. Pasteur 1173P2 competence damage-inducible protein A YP_978030.1 2148692 D 410289 CDS YP_978031.1 121637808 4698349 complement(2150036..2151304) 1 NC_008769.1 sialic acid-transport integral membrane protein nanT 2151304 nanT 4698349 nanT Mycobacterium bovis BCG str. Pasteur 1173P2 sialic acid-transport integral membrane protein nanT YP_978031.1 2150036 R 410289 CDS YP_978032.1 121637809 4696618 2151394..2151798 1 NC_008769.1 hypothetical protein 2151798 4696618 BCG_1942 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978032.1 2151394 D 410289 CDS YP_978033.1 121637810 4697409 2151984..2152415 1 NC_008769.1 Differs from Rv1904 by 1aa, M130T; hypothetical protein 2152415 4697409 BCG_1943 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978033.1 2151984 D 410289 CDS YP_978034.1 121637811 4695380 complement(2152463..2153425) 1 NC_008769.1 Differs from Rv1905c by 1aa, T240P; D-amino acid oxidase aao 2153425 aao 4695380 aao Mycobacterium bovis BCG str. Pasteur 1173P2 D-amino acid oxidase aao YP_978034.1 2152463 R 410289 CDS YP_978035.1 121637812 4697430 complement(2153455..2153925) 1 NC_008769.1 hypothetical protein 2153925 4697430 BCG_1945c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978035.1 2153455 R 410289 CDS YP_978036.1 121637813 4695366 complement(2154265..2154912) 1 NC_008769.1 hypothetical protein 2154912 4695366 BCG_1946c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978036.1 2154265 R 410289 CDS YP_978037.1 121637814 4695391 complement(2154919..2157141) 1 NC_008769.1 Differs from Rv1908c by 1aa, L463R; catalase-peroxidase-peroxynitritase T katG 2157141 katG 4695391 katG Mycobacterium bovis BCG str. Pasteur 1173P2 catalase-peroxidase-peroxynitritase T katG YP_978037.1 2154919 R 410289 CDS YP_978038.1 121637815 4697351 complement(2157179..2157631) 1 NC_008769.1 Differs from Rv1909c and Mb1944c by 1aa, V46A; ferric uptake regulation protein furA 2157631 furA 4697351 furA Mycobacterium bovis BCG str. Pasteur 1173P2 ferric uptake regulation protein furA YP_978038.1 2157179 R 410289 CDS YP_978039.1 121637816 4695504 complement(2157736..2158329) 1 NC_008769.1 hypothetical protein 2158329 4695504 BCG_1949c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978039.1 2157736 R 410289 CDS YP_978040.1 121637817 4698446 complement(2158412..2159017) 1 NC_008769.1 lipoprotein lppC 2159017 lppC 4698446 lppC Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppC YP_978040.1 2158412 R 410289 CDS YP_978041.1 121637818 4699201 complement(2159117..2160121) 1 NC_008769.1 Differs from Rv1912c by 1aa, G328D; oxidoreductase fadB5 2160121 fadB5 4699201 fadB5 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase fadB5 YP_978041.1 2159117 R 410289 CDS YP_978042.1 121637819 4697104 2160221..2160973 1 NC_008769.1 Differs from Rv1913 and Mb1948 by 1aa, C7R; hypothetical protein 2160973 4697104 BCG_1952 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978042.1 2160221 D 410289 CDS YP_978043.1 121637820 4697533 complement(2160951..2161358) 1 NC_008769.1 hypothetical protein 2161358 4697533 BCG_1953c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978043.1 2160951 R 410289 CDS YP_978044.1 121637821 4695403 2161493..2163793 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, aceAa and aceAb exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base insertion (*-t) leads to a single product; isocitrate lyase aceA 2163793 aceA 4695403 aceA Mycobacterium bovis BCG str. Pasteur 1173P2 isocitrate lyase aceA YP_978044.1 2161493 D 410289 CDS YP_978045.1 121637822 4698950 complement(2163963..2169470) 1 NC_008769.1 Equivalent to Mb1951c and Rv1917c but differs by several in-frame insertion and deletion events. Differs from Mb1951c by 69 bp insertion, 69 bp deletion and 225 bp deletion. Differs from Rv1917c by deletions of 12 and 138 bp, insertions of 552 and 150 bp, and substitution of 52 bp by 628 bp; PPE family protein 2169470 PPE34 4698950 PPE34 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_978045.1 2163963 R 410289 CDS YP_978046.1 121637823 4696450 complement(2170895..2172772) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PPE35 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-t) splits PPE35 into 2 parts, PPE35a and PPE35b. Differs from Mb1953c by 1aa, F565V; PPE family protein 2172772 PPE35a 4696450 PPE35a Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_978046.1 2170895 R 410289 CDS YP_978047.1 121637824 4696449 complement(2173221..2173685) 1 NC_008769.1 hypothetical protein 2173685 4696449 BCG_1958c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978047.1 2173221 R 410289 CDS YP_978048.1 121637825 4698656 2173783..2174646 1 NC_008769.1 Differs from Rv1920 by 1aa, I130M; hypothetical protein 2174646 4698656 BCG_1959 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978048.1 2173783 D 410289 CDS YP_978049.1 121637826 4699375 complement(2174684..2175955) 1 NC_008769.1 lipoprotein lppF 2175955 lppF 4699375 lppF Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppF YP_978049.1 2174684 R 410289 CDS YP_978050.1 121637827 4696495 2176227..2177342 1 NC_008769.1 lipoprotein 2177342 4696495 BCG_1961 Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein YP_978050.1 2176227 D 410289 CDS YP_978051.1 121637828 4697421 2177333..2178673 1 NC_008769.1 Differs from Rv1923 by 2aa, D73G, N181D; lipase lipD 2178673 lipD 4697421 lipD Mycobacterium bovis BCG str. Pasteur 1173P2 lipase lipD YP_978051.1 2177333 D 410289 CDS YP_978052.1 121637829 4698689 complement(2178710..2179090) 1 NC_008769.1 hypothetical protein 2179090 4698689 BCG_1963c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978052.1 2178710 R 410289 CDS YP_978053.1 121637830 4695416 2179247..2181109 1 NC_008769.1 activates fatty acids by binding to coenzyme A; fatty-acid--CoA ligase 2181109 fadD31 4695416 fadD31 Mycobacterium bovis BCG str. Pasteur 1173P2 fatty-acid--CoA ligase YP_978053.1 2179247 D 410289 CDS YP_978054.1 121637831 4697645 complement(2181117..2181596) 1 NC_008769.1 immunogenic protein mpt63 2181596 mpt63 4697645 mpt63 Mycobacterium bovis BCG str. Pasteur 1173P2 immunogenic protein mpt63 YP_978054.1 2181117 R 410289 CDS YP_978055.1 121637832 4698094 2181833..2182606 1 NC_008769.1 hypothetical protein 2182606 4698094 BCG_1966 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978055.1 2181833 D 410289 CDS YP_978056.1 121637833 4695456 complement(2182610..2183377) 1 NC_008769.1 short chain dehydrogenase 2183377 4695456 BCG_1967c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_978056.1 2182610 R 410289 CDS YP_978057.1 121637834 4695446 complement(2183422..2184066) 1 NC_008769.1 hypothetical protein 2184066 4695446 BCG_1968c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978057.1 2183422 R 410289 CDS YP_978058.1 121637835 4698059 complement(2184078..2184602) 1 NC_008769.1 hypothetical protein 2184602 4698059 BCG_1969c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978058.1 2184078 R 410289 CDS YP_978059.1 121637836 4695353 complement(2184620..2185399) 1 NC_008769.1 transcriptional regulatory protein 2185399 4695353 BCG_1970c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_978059.1 2184620 R 410289 CDS YP_978060.1 121637837 4695644 2185532..2186029 1 NC_008769.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 2186029 tpx 4695644 tpx Mycobacterium bovis BCG str. Pasteur 1173P2 thiol peroxidase YP_978060.1 2185532 D 410289 CDS YP_978061.1 121637838 4696390 complement(2186026..2187117) 1 NC_008769.1 acyl-CoA dehydrogenase fadE18 2187117 fadE18 4696390 fadE18 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE18 YP_978061.1 2186026 R 410289 CDS YP_978062.1 121637839 4697445 complement(2187119..2188348) 1 NC_008769.1 acyl-CoA dehydrogenase fadE17 2188348 fadE17 4697445 fadE17 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE17 YP_978062.1 2187119 R 410289 CDS YP_978063.1 121637840 4697444 complement(2188363..2189319) 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2189319 echA13 4697444 echA13 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_978063.1 2188363 R 410289 CDS YP_978064.1 121637841 4697098 2189544..2190653 1 NC_008769.1 monooxygenase 2190653 4697098 BCG_1975 Mycobacterium bovis BCG str. Pasteur 1173P2 monooxygenase YP_978064.1 2189544 D 410289 CDS YP_978065.1 121637842 4696262 2190656..2193175 1 NC_008769.1 oxygenase 2193175 4696262 BCG_1976 Mycobacterium bovis BCG str. Pasteur 1173P2 oxygenase YP_978065.1 2190656 D 410289 CDS YP_978066.1 121637843 4695500 2193187..2194257 1 NC_008769.1 epoxide hydrolase ephB 2194257 ephB 4695500 ephB Mycobacterium bovis BCG str. Pasteur 1173P2 epoxide hydrolase ephB YP_978066.1 2193187 D 410289 CDS YP_978067.1 121637844 4697908 2194254..2194769 1 NC_008769.1 In Mycobacterium bovis, a single base deletion (t-*) leads to a longer product with a different COOH part compared to its homologs in Mycobacterium tuberculosis H37Rv and Mycobacterium bovis BCG Pasteur (244 aa versus 171 aa); oxidoreductase 2194769 4697908 BCG_1978 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_978067.1 2194254 D 410289 CDS YP_978068.1 121637845 4695447 2194766..2195827 1 NC_008769.1 riboflavin biosynthesis protein ribA1 (GTP cyclohydrolase II) 2195827 ribA1 4695447 ribA1 Mycobacterium bovis BCG str. Pasteur 1173P2 riboflavin biosynthesis protein ribA1 (GTP cyclohydrolase II) YP_978068.1 2194766 D 410289 CDS YP_978069.1 121637846 4696888 2195824..2196594 1 NC_008769.1 short-chain type dehydrogenase/reductase 2196594 4696888 BCG_1980 Mycobacterium bovis BCG str. Pasteur 1173P2 short-chain type dehydrogenase/reductase YP_978069.1 2195824 D 410289 CDS YP_978070.1 121637847 4695738 complement(2196804..2197133) 1 NC_008769.1 hypothetical protein 2197133 4695738 BCG_1981c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978070.1 2196804 R 410289 CDS YP_978071.1 121637848 4695576 complement(2197130..2197507) 1 NC_008769.1 hypothetical protein 2197507 4695576 BCG_1982c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978071.1 2197130 R 410289 CDS YP_978072.1 121637849 4696412 complement(2197504..2198094) 1 NC_008769.1 Differs from Rv1944c and Mb1979c by 2aa, E4D, A5T, due to 2 bp substitution ta-cc; hypothetical protein 2198094 4696412 BCG_1983c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978072.1 2197504 R 410289 CDS YP_978073.1 121637850 4698225 2198149..2199513 1 NC_008769.1 Differs from Mb1980 and Rv1945 by substitutions of 44, 29, 2, 10 and 34 bp, or 44, 29, 4, 2, 10 and 34 bp, respectively. Corresponding to 10 aa from Rv1945, L242V, N264H, A267G, F268L, A271G, K285R, I291V, N328H, H417K and P426A, and to 9 aa from MB1980, N264H, A267G, F268L, A271G, K285R, I291V, N328H, H417K and P426A; hypothetical protein 2199513 4698225 BCG_1984 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978073.1 2198149 D 410289 CDS YP_978074.1 121637851 4696744 complement(2199668..2200120) 1 NC_008769.1 Differs from Rv1946c by 1aa, T98A; lipoprotein 2200120 lppG 4696744 lppG Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein YP_978074.1 2199668 R 410289 CDS YP_978075.1 121637852 4696496 2200184..2200585 1 NC_008769.1 hypothetical protein 2200585 4696496 BCG_1986 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978075.1 2200184 D 410289 CDS YP_978076.1 121637853 4696135 complement(2200874..2201224) 1 NC_008769.1 Differs from Rv1948c by 1aa, R5G; hypothetical protein 2201224 4696135 BCG_1987c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978076.1 2200874 R 410289 CDS YP_978077.1 121637854 4698911 complement(2201235..2202137) 1 NC_008769.1 Differs from Rv1949c by 1aa, L188F; hypothetical protein 2202137 4698911 BCG_1988c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978077.1 2201235 R 410289 CDS YP_978078.1 121637855 4697182 complement(2202158..2202349) 1 NC_008769.1 hypothetical protein 2202349 4697182 BCG_1989c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978078.1 2202158 R 410289 CDS YP_978079.1 121637856 4696896 complement(2202350..2202646) 1 NC_008769.1 hypothetical protein 2202646 4696896 BCG_1990c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978079.1 2202350 R 410289 CDS YP_978080.1 121637857 4697217 2202886..2203101 1 NC_008769.1 hypothetical protein 2203101 4697217 BCG_1991 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978080.1 2202886 D 410289 CDS YP_978081.1 121637858 4697670 2203098..2203409 1 NC_008769.1 hypothetical protein 2203409 4697670 BCG_1992 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978081.1 2203098 D 410289 CDS YP_978082.1 121637859 4697133 complement(2203383..2203904) 1 NC_008769.1 Differs from Rv1954c by 1aa, R150H; hypothetical protein 2203904 4697133 BCG_1993c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978082.1 2203383 R 410289 CDS YP_978083.1 121637860 4697512 2203744..2204256 1 NC_008769.1 hypothetical protein 2204256 4697512 BCG_1994 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978083.1 2203744 D 410289 CDS YP_978084.1 121637861 4697321 2204298..2204747 1 NC_008769.1 transcriptional regulatory protein 2204747 4697321 BCG_1995 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_978084.1 2204298 D 410289 CDS YP_978085.1 121637862 4697449 2204744..2205289 1 NC_008769.1 hypothetical protein 2205289 4697449 BCG_1996 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978085.1 2204744 D 410289 CDS YP_978086.1 121637863 4697766 complement(2205178..2205792) 1 NC_008769.1 hypothetical protein 2205792 4697766 BCG_1997c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978086.1 2205178 R 410289 CDS YP_978087.1 121637864 4698064 complement(2205841..2206137) 1 NC_008769.1 hypothetical protein 2206137 4698064 BCG_1998c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978087.1 2205841 R 410289 CDS YP_978088.1 121637865 4699260 complement(2206134..2206385) 1 NC_008769.1 hypothetical protein 2206385 4699260 BCG_1999c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978088.1 2206134 R 410289 CDS YP_978089.1 121637866 4697773 2206372..2206866 1 NC_008769.1 hypothetical protein 2206866 4697773 BCG_2000 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978089.1 2206372 D 410289 CDS YP_978090.1 121637867 4699089 complement(2207026..2207433) 1 NC_008769.1 hypothetical protein 2207433 4699089 BCG_2001c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978090.1 2207026 R 410289 CDS YP_978091.1 121637868 4698013 complement(2207437..2207709) 1 NC_008769.1 antitoxin 2207709 4698013 BCG_2001A Mycobacterium bovis BCG str. Pasteur 1173P2 antitoxin YP_978091.1 2207437 R 410289 CDS YP_978092.1 121637869 4698027 complement(2207742..2208962) 1 NC_008769.1 transcriptional regulatory protein 2208962 4698027 BCG_2002c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_978092.1 2207742 R 410289 CDS YP_978093.1 121637870 4699329 2209861..2210265 1 NC_008769.1 In Mycobacterium bovis an in Mycobacterium bovis BCG Pasteur, a large deletion of 12719 bp (RD7) leads to the loss of the COOH part of Rv1964|yrbE3A, the entire mce3 operon and the following genes up to Rv1978, compared to Mycobacterium tuberculosis strain H37Rv. Follow by a second deletion of 10287bp, RD2 region (only in Mycobacterium bovis BCG Pasteur), which removes genes Rv1979c-Rv1787 and merges truncated part of Rv1978 and Rv1988 compared to Mycobacterium tuberculosis strain H37Rv; integral membrane protein YrbE3a 2210265 yrbE3A 4699329 yrbE3A Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YrbE3a YP_978093.1 2209861 D 410289 CDS YP_978094.1 121637871 4695513 2210350..2210874 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, a large deletion of 10787 bp, RD2, removes genes Rv1979c-Rv1987 and merges truncated part of Rv1978 and Rv1988 compared to Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis AF2122/97; methyltransferase 2210874 4695513 BCG_2004 Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase YP_978094.1 2210350 D 410289 CDS YP_978095.1 121637872 4698763 complement(2211394..2211954) 1 NC_008769.1 hypothetical protein 2211954 4698763 BCG_2005c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978095.1 2211394 R 410289 CDS YP_978096.1 121637873 4698530 complement(2211951..2212292) 1 NC_008769.1 transcriptional regulatory protein 2212292 4698530 BCG_2006c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_978096.1 2211951 R 410289 CDS YP_978097.1 121637874 4698927 complement(2212536..2212871) 1 NC_008769.1 dehydrogenase 2212871 4698927 BCG_2007c Mycobacterium bovis BCG str. Pasteur 1173P2 dehydrogenase YP_978097.1 2212536 R 410289 CDS YP_978098.1 121637875 4698489 complement(2212960..2213304) 1 NC_008769.1 hypothetical protein 2213304 4698489 BCG_2008c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978098.1 2212960 R 410289 CDS YP_978099.1 121637876 4698502 complement(2213646..2215961) 1 NC_008769.1 metal cation transporter P-type atpase G ctpG 2215961 ctpG 4698502 ctpG Mycobacterium bovis BCG str. Pasteur 1173P2 metal cation transporter P-type atpase G ctpG YP_978099.1 2213646 R 410289 CDS YP_978100.1 121637877 4696427 complement(2215958..2216230) 1 NC_008769.1 hypothetical protein 2216230 4696427 BCG_2010c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978100.1 2215958 R 410289 CDS YP_978101.1 121637878 4698000 complement(2216283..2216639) 1 NC_008769.1 transcriptional regulatory protein 2216639 4698000 BCG_2011c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_978101.1 2216283 R 410289 CDS YP_978102.1 121637879 4697915 2216796..2217563 1 NC_008769.1 hypothetical protein 2217563 4697915 BCG_2012 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978102.1 2216796 D 410289 CDS YP_978103.1 121637880 4698052 2217659..2218612 1 NC_008769.1 hypothetical protein 2218612 4698052 BCG_2013 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978103.1 2217659 D 410289 CDS YP_978104.1 121637881 4697934 2218814..2221531 1 NC_008769.1 Differs from Rv1997 and Mb2020 by 1aa, D138E; metal cation transporter P-type atpase A ctpF 2221531 ctpF 4697934 ctpF Mycobacterium bovis BCG str. Pasteur 1173P2 metal cation transporter P-type atpase A ctpF YP_978104.1 2218814 D 410289 CDS YP_978105.1 121637882 4695897 complement(2221600..2222376) 1 NC_008769.1 Differs from Rv1998c by 1aa, R230S; hypothetical protein 2222376 4695897 BCG_2015c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978105.1 2221600 R 410289 CDS YP_978106.1 121637883 4698456 complement(2222471..2223793) 1 NC_008769.1 integral membrane protein 2223793 4698456 BCG_2016c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_978106.1 2222471 R 410289 CDS YP_978107.1 121637884 4698476 2223864..2225477 1 NC_008769.1 hypothetical protein 2225477 4698476 BCG_2017 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978107.1 2223864 D 410289 CDS YP_978108.1 121637885 4698480 2225487..2226239 1 NC_008769.1 Differs from Rv2001 by 1aa, H113R; hypothetical protein 2226239 4698480 BCG_2018 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978108.1 2225487 D 410289 CDS YP_978109.1 121637886 4698258 2226315..2227097 1 NC_008769.1 20-beta-hydroxysteroid dehydrogenase fabG3 2227097 fabG3 4698258 fabG3 Mycobacterium bovis BCG str. Pasteur 1173P2 20-beta-hydroxysteroid dehydrogenase fabG3 YP_978109.1 2226315 D 410289 CDS YP_978110.1 121637887 4696227 complement(2227218..2228075) 1 NC_008769.1 hypothetical protein 2228075 4696227 BCG_2020c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978110.1 2227218 R 410289 CDS YP_978111.1 121637888 4698344 complement(2228133..2229629) 1 NC_008769.1 hypothetical protein 2229629 4698344 BCG_2021c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978111.1 2228133 R 410289 CDS YP_978112.1 121637889 4697401 complement(2229651..2230538) 1 NC_008769.1 hypothetical protein 2230538 4697401 BCG_2022c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978112.1 2229651 R 410289 CDS YP_978113.1 121637890 4697416 2230657..2234640 1 NC_008769.1 Differs from Rv2006 and Mb2029 by 1aa, S80G and L1245P, respectively; trehalose-6-phosphate phosphatase otsB1 2234640 otsB1 4697416 otsB1 Mycobacterium bovis BCG str. Pasteur 1173P2 trehalose-6-phosphate phosphatase otsB1 YP_978113.1 2230657 D 410289 CDS YP_978114.1 121637891 4698923 complement(2234739..2235083) 1 NC_008769.1 ferredoxin fdxA 2235083 fdxA 4698923 fdxA Mycobacterium bovis BCG str. Pasteur 1173P2 ferredoxin fdxA YP_978114.1 2234739 R 410289 CDS YP_978115.1 121637892 4696526 complement(2235272..2236597) 1 NC_008769.1 hypothetical protein 2236597 4696526 BCG_2025c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978115.1 2235272 R 410289 CDS YP_978116.1 121637893 4697410 2236685..2236927 1 NC_008769.1 Differs from Rv2009 by 1aa, D63N; hypothetical protein 2236927 4697410 BCG_2026 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978116.1 2236685 D 410289 CDS YP_978117.1 121637894 4696507 2236928..2237326 1 NC_008769.1 hypothetical protein 2237326 4696507 BCG_2027 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978117.1 2236928 D 410289 CDS YP_978118.1 121637895 4698188 complement(2237509..2237940) 1 NC_008769.1 hypothetical protein 2237940 4698188 BCG_2028c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978118.1 2237509 R 410289 CDS YP_978119.1 121637896 4697392 2237981..2238475 1 NC_008769.1 hypothetical protein 2238475 4697392 BCG_2029 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978119.1 2237981 D 410289 CDS YP_978120.1 121637897 4696130 2239179..2239796 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base transition (c-t) at the 5' start, leads to a longer product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (206 aa versus 159 aa); transposase 2239796 4696130 BCG_2030 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_978120.1 2239179 D 410289 CDS YP_978121.1 121637898 4698598 2239750..2240340 1 NC_008769.1 Identical to Mb2037 including extra 5 aa at C-terminus compared to Rv2014; transposase 2240340 4698598 BCG_2031 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_978121.1 2239750 D 410289 CDS YP_978122.1 121637899 4697391 complement(2240468..2241724) 1 NC_008769.1 Differs from Mb2038c by 1aa S59L; hypothetical protein 2241724 4697391 BCG_2032c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978122.1 2240468 R 410289 CDS YP_978123.1 121637900 4695370 2242078..2242653 1 NC_008769.1 hypothetical protein 2242653 4695370 BCG_2033 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978123.1 2242078 D 410289 CDS YP_978124.1 121637901 4695867 2242650..2243690 1 NC_008769.1 Differs from Rv2017 by 1aa, E262A; regulatory protein 2243690 4695867 BCG_2034 Mycobacterium bovis BCG str. Pasteur 1173P2 regulatory protein YP_978124.1 2242650 D 410289 CDS YP_978125.1 121637902 4696328 2243932..2244651 1 NC_008769.1 Differs from Rv2018 by 1aa, G116D; hypothetical protein 2244651 4696328 BCG_2035 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978125.1 2243932 D 410289 CDS YP_978126.1 121637903 4698882 2244641..2245057 1 NC_008769.1 hypothetical protein 2245057 4698882 BCG_2036 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978126.1 2244641 D 410289 CDS YP_978127.1 121637904 4699004 complement(2245073..2245372) 1 NC_008769.1 hypothetical protein 2245372 4699004 BCG_2037c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978127.1 2245073 R 410289 CDS YP_978128.1 121637905 4698829 complement(2245457..2245762) 1 NC_008769.1 hypothetical protein 2245762 4698829 BCG_2038c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978128.1 2245457 R 410289 CDS YP_978129.1 121637906 4696410 complement(2245771..2246376) 1 NC_008769.1 hypothetical protein 2246376 4696410 BCG_2039c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978129.1 2245771 R 410289 CDS YP_978130.1 121637907 4698654 complement(2246401..2246760) 1 NC_008769.1 hypothetical protein 2246760 4698654 BCG_2040c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978130.1 2246401 R 410289 CDS YP_978131.1 121637908 4698711 complement(2246920..2247597) 1 NC_008769.1 Belongs to the RvD1 region. Absent in Mycobacterium tuberculosis strain H37Rv; hypothetical protein 2247597 4698711 BCG_2041c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978131.1 2246920 R 410289 CDS YP_978132.1 121637909 4699084 complement(2247992..2248888) 1 NC_008769.1 Belongs to the RvD1 region. Absent in Mycobacterium tuberculosis strain H37Rv; Differs from Mb2048c by 1aa, E139K; hypothetical protein 2248888 4699084 BCG_2042c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978132.1 2247992 R 410289 CDS YP_978133.1 121637910 4698652 complement(2249072..2253892) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, a large deletion region (RvD1) exists in between Rv2023 and Rv2024. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 5000 bp insertion at this region results in Mb2049c being a much larger product with a different COOH part (1606 aa versus 515 aa), and in 2 extra genes, Mb2046c and Mb2047c; Differs from N-terminal part of Rv2024c (truncated by RvD1) by 3aa, R47W, G154D, C289R and Mb2049c by 1aa, F341V; hypothetical protein 2253892 4698652 BCG_2043c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978133.1 2249072 R 410289 CDS YP_978134.1 121637911 4697333 complement(2254402..2255400) 1 NC_008769.1 hypothetical protein 2255400 4697333 BCG_2044c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978134.1 2254402 R 410289 CDS YP_978135.1 121637912 4695736 complement(2255515..2256399) 1 NC_008769.1 hypothetical protein 2256399 4695736 BCG_2045c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978135.1 2255515 R 410289 CDS YP_978136.1 121637913 4698869 complement(2256439..2258160) 1 NC_008769.1 Differs from Rv2027c by 1aa, V15L; histidine kinase response regulator 2258160 4698869 BCG_2046c Mycobacterium bovis BCG str. Pasteur 1173P2 histidine kinase response regulator YP_978136.1 2256439 R 410289 CDS YP_978137.1 121637914 4695619 complement(2258221..2259060) 1 NC_008769.1 hypothetical protein 2259060 4695619 BCG_2047c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978137.1 2258221 R 410289 CDS YP_978138.1 121637915 4698037 complement(2259057..2260076) 1 NC_008769.1 phosphofructokinase pfkB 2260076 pfkB 4698037 pfkB Mycobacterium bovis BCG str. Pasteur 1173P2 phosphofructokinase pfkB YP_978138.1 2259057 R 410289 CDS YP_978139.1 121637916 4698543 complement(2260093..2262138) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG Pasteur, Rv2030c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv2030c into 2 parts, Mb2055c and Mb2056c; hypothetical protein 2262138 4698543 BCG_2049c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978139.1 2260093 R 410289 CDS YP_978140.1 121637917 4696845 complement(2262150..2262584) 1 NC_008769.1 heat shock protein hspX 2262584 hspX 4696845 hspX Mycobacterium bovis BCG str. Pasteur 1173P2 heat shock protein hspX YP_978140.1 2262150 R 410289 CDS YP_978141.1 121637918 4696302 2262781..2263776 1 NC_008769.1 Differs from Rv2032 by 1aa, L318P; hypothetical protein 2263776 4696302 BCG_2051 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978141.1 2262781 D 410289 CDS YP_978142.1 121637919 4696373 complement(2263892..2264734) 1 NC_008769.1 hypothetical protein 2264734 4696373 BCG_2052c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978142.1 2263892 R 410289 CDS YP_978143.1 121637920 4696623 2264946..2265269 1 NC_008769.1 ArsR family transcriptional regulator 2265269 4696623 BCG_2053 Mycobacterium bovis BCG str. Pasteur 1173P2 ArsR family transcriptional regulator YP_978143.1 2264946 D 410289 CDS YP_978144.1 121637921 4696875 2265266..2265754 1 NC_008769.1 hypothetical protein 2265754 4696875 BCG_2054 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978144.1 2265266 D 410289 CDS YP_978145.1 121637922 4697617 2265751..2266392 1 NC_008769.1 Differs from Rv2036 by 1aa, V93A due to 2bp substitution cc-tt; hypothetical protein 2266392 4697617 BCG_2055 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978145.1 2265751 D 410289 CDS YP_978146.1 121637923 4696860 complement(2266399..2267373) 1 NC_008769.1 Differs from Rv2037c by 1aa, Y312C; hypothetical protein 2267373 4696860 BCG_2056c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978146.1 2266399 R 410289 CDS YP_978147.1 121637924 4697201 complement(2267375..2268448) 1 NC_008769.1 sugar-transport ATP-binding protein ABC transporter 2268448 4697201 BCG_2057c Mycobacterium bovis BCG str. Pasteur 1173P2 sugar-transport ATP-binding protein ABC transporter YP_978147.1 2267375 R 410289 CDS YP_978148.1 121637925 4697679 complement(2268451..2269293) 1 NC_008769.1 Differs from Rv2039c by 1aa, F131V; sugar-transport integral membrane protein ABC transporter 2269293 4697679 BCG_2058c Mycobacterium bovis BCG str. Pasteur 1173P2 sugar-transport integral membrane protein ABC transporter YP_978148.1 2268451 R 410289 CDS YP_978149.1 121637926 4695484 complement(2269280..2270182) 1 NC_008769.1 sugar-transport integral membrane protein ABC transporter 2270182 4695484 BCG_2059c Mycobacterium bovis BCG str. Pasteur 1173P2 sugar-transport integral membrane protein ABC transporter YP_978149.1 2269280 R 410289 CDS YP_978150.1 121637927 4696858 complement(2270179..2271498) 1 NC_008769.1 Differs from Mb2067c by 1aa, A122V; sugar-binding lipoprotein 2271498 4696858 BCG_2060c Mycobacterium bovis BCG str. Pasteur 1173P2 sugar-binding lipoprotein YP_978150.1 2270179 R 410289 CDS YP_978151.1 121637928 4698044 complement(2271536..2272333) 1 NC_008769.1 hypothetical protein 2272333 4698044 BCG_2061c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978151.1 2271536 R 410289 CDS YP_978152.1 121637929 4695737 complement(2272333..2272893) 1 NC_008769.1 Differs from Rv2043c by 1aa, D57H; pyrazinamidase/nicotinamidas pncA 2272893 pncA 4695737 pncA Mycobacterium bovis BCG str. Pasteur 1173P2 pyrazinamidase/nicotinamidas pncA YP_978152.1 2272333 R 410289 CDS YP_978153.1 121637930 4696815 complement(2272934..2273251) 1 NC_008769.1 hypothetical protein 2273251 4696815 BCG_2063c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978153.1 2272934 R 410289 CDS YP_978154.1 121637931 4698638 complement(2273337..2274872) 1 NC_008769.1 carboxylesterase LipT 2274872 lipT 4698638 lipT Mycobacterium bovis BCG str. Pasteur 1173P2 carboxylesterase LipT YP_978154.1 2273337 R 410289 CDS YP_978155.1 121637932 4696905 2274921..2275577 1 NC_008769.1 Differs from Rv2046 by 1aa, P17S; lipoprotein lppI 2275577 lppI 4696905 lppI Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppI YP_978155.1 2274921 D 410289 CDS YP_978156.1 121637933 4696498 complement(2275614..2278178) 1 NC_008769.1 hypothetical protein 2278178 4696498 BCG_2066c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978156.1 2275614 R 410289 CDS YP_978157.1 121637934 4697764 complement(2278183..2290638) 1 NC_008769.1 Differs from Mb2074c and Rv2048c in several positions due to various substitutions, transitions and transversions; polyketide synthase 2290638 pks12 4697764 pks12 Mycobacterium bovis BCG str. Pasteur 1173P2 polyketide synthase YP_978157.1 2278183 R 410289 CDS YP_978158.1 121637935 4696192 complement(2290945..2291169) 1 NC_008769.1 hypothetical protein 2291169 4696192 BCG_2068c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978158.1 2290945 R 410289 CDS YP_978159.1 121637936 4696062 2291473..2291808 1 NC_008769.1 hypothetical protein 2291808 4696062 BCG_2069 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978159.1 2291473 D 410289 CDS YP_978160.1 121637937 4696084 complement(2291783..2294407) 1 NC_008769.1 polyprenol-monophosphomannose synthase Ppm1 2294407 ppm1 4696084 ppm1 Mycobacterium bovis BCG str. Pasteur 1173P2 polyprenol-monophosphomannose synthase Ppm1 YP_978160.1 2291783 R 410289 CDS YP_978161.1 121637938 4698103 complement(2294565..2296169) 1 NC_008769.1 hypothetical protein 2296169 4698103 BCG_2071c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978161.1 2294565 R 410289 CDS YP_978162.1 121637939 4697837 complement(2296174..2296701) 1 NC_008769.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 2296701 fxsA 4697837 fxsA Mycobacterium bovis BCG str. Pasteur 1173P2 FxsA protein YP_978162.1 2296174 R 410289 CDS YP_978163.1 121637940 4696573 2296777..2297490 1 NC_008769.1 hypothetical protein 2297490 4696573 BCG_2073 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978163.1 2296777 D 410289 CDS YP_978164.1 121637941 4697123 complement(2297739..2298005) 1 NC_008769.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 2298005 rpsR2 4697123 rpsR2 Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S18 YP_978164.1 2297739 R 410289 CDS YP_978165.1 121637942 4695808 complement(2298006..2298311) 1 NC_008769.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 2298311 rpsN 4695808 rpsN Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S14 YP_978165.1 2298006 R 410289 CDS YP_978166.1 121637943 4698852 complement(2298313..2298477) 1 NC_008769.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 2298477 rpmG 4698852 rpmG Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L33 YP_978166.1 2298313 R 410289 CDS YP_978167.1 121637944 4696787 complement(2298477..2298713) 1 NC_008769.1 required for 70S ribosome assembly; 50S ribosomal protein L28 2298713 rpmB 4696787 rpmB Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L28 YP_978167.1 2298477 R 410289 CDS YP_978168.1 121637945 4697630 2298826..2300361 1 NC_008769.1 hypothetical protein 2300361 4697630 BCG_2078 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978168.1 2298826 D 410289 CDS YP_978170.1 121637946 4698440 complement(2300333..2300737) 1 NC_008769.1 hypothetical protein 2300737 4698440 BCG_2080c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978170.1 2300333 R 410289 CDS YP_978171.1 121637947 4698254 complement(2300821..2304405) 1 NC_008769.1 with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism; cobaltochelatase subunit CobN 2304405 cobN 4698254 cobN Mycobacterium bovis BCG str. Pasteur 1173P2 cobaltochelatase subunit CobN YP_978171.1 2300821 R 410289 CDS YP_978172.1 121637948 4699241 2304483..2304716 1 NC_008769.1 hypothetical protein 2304716 4699241 BCG_2082 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978172.1 2304483 D 410289 CDS YP_978173.1 121637949 4697422 2305103..2306194 1 NC_008769.1 cobalamin biosynthesis protein CobG 2306194 cobG 4697422 cobG Mycobacterium bovis BCG str. Pasteur 1173P2 cobalamin biosynthesis protein CobG YP_978173.1 2305103 D 410289 CDS YP_978174.1 121637950 4697941 2306204..2306830 1 NC_008769.1 catalyzes the interconversion of precorrin-8X and hydrogenobyrinate; precorrin-8X methylmutase 2306830 cobH 4697941 cobH Mycobacterium bovis BCG str. Pasteur 1173P2 precorrin-8X methylmutase YP_978174.1 2306204 D 410289 CDS YP_978175.1 121637951 4698935 2306827..2308353 1 NC_008769.1 bifunctional protein, CobI-CobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase 2308353 cobI 4698935 cobI Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional protein, CobI-CobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase YP_978175.1 2306827 D 410289 CDS YP_978176.1 121637952 4699079 complement(2308299..2309522) 1 NC_008769.1 hypothetical protein 2309522 4699079 BCG_2086c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978176.1 2308299 R 410289 CDS YP_978177.1 121637953 4696440 complement(2309538..2310461) 1 NC_008769.1 beta-lactamase 2310461 blaC 4696440 blaC Mycobacterium bovis BCG str. Pasteur 1173P2 beta-lactamase YP_978177.1 2309538 R 410289 CDS YP_978178.1 121637954 4696315 2310596..2311153 1 NC_008769.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigC 2311153 sigC 4696315 sigC Mycobacterium bovis BCG str. Pasteur 1173P2 RNA polymerase sigma factor SigC YP_978178.1 2310596 D 410289 CDS YP_978179.1 121637955 4695815 complement(2311143..2311838) 1 NC_008769.1 CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; cobalt-precorrin-6x reductase 2311838 cobK 4695815 cobK Mycobacterium bovis BCG str. Pasteur 1173P2 cobalt-precorrin-6x reductase YP_978179.1 2311143 R 410289 CDS YP_978180.1 121637956 4698684 complement(2311875..2312630) 1 NC_008769.1 Differs from Rv2071c by 1aa, M145I; precorrin-4 C11-methyltransferase CobM 2312630 cobM 4698684 cobM Mycobacterium bovis BCG str. Pasteur 1173P2 precorrin-4 C11-methyltransferase CobM YP_978180.1 2311875 R 410289 CDS YP_978181.1 121637957 4699302 complement(2312627..2313511) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a large 2029 bp deletion (H37Rv2.2330073-2332101-*)(RD9) leads to the loss of the NH2 part of cobL, the entire Rv2073 and Rv2074, and the COOH part of Mb2100c. In addition, while cobL exists as a single gene in Mycobacterium tuberculosis strain H37Rv, in Mycobacterium bovis a frameshift due to a single base insertion (*-t) splits cobL into 2 parts, cobLa and cobLb; precorrin-6y methyltransferase CobLb 2313511 cobLb 4699302 cobLb Mycobacterium bovis BCG str. Pasteur 1173P2 precorrin-6y methyltransferase CobLb YP_978181.1 2312627 R 410289 CDS YP_978182.1 121637958 4699052 complement(2313453..2313641) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a large deletion of 2029 bp (H37Rv2.2330073-2332101-*) (RD9) leads to the loss of the NH2 part of cobL, the entire Rv2073 and Rv2074, and the COOH part of Rv2075c. In addition, while cobL exists as a single gene in Mycobacterium tuberculosis strain H37Rv, in Mycobacterium bovis a frameshift due to a single base insertion (*-t) splits cobL into 2 parts, cobLa and cobLb; precorrin-6y methyltransferase CobLa 2313641 cobLa 4699052 cobLa Mycobacterium bovis BCG str. Pasteur 1173P2 precorrin-6y methyltransferase CobLa YP_978182.1 2313453 R 410289 CDS YP_978183.1 121637959 4699124 complement(2313716..2314504) 1 NC_008769.1 In Mycobacterium bovis AF2122/97 and in Mycobacterium bovis BCG Pasteur, a large 2029 bp deletion (RD9) leads to the loss of the COOH part of Mb2100c, the entire Rv2074 and Rv2073, and the NH2 part of cobL compared to its homolog in Mycobacterium tuberculosis strain H37Rv; hypothetical protein 2314504 4699124 BCG_2093c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978183.1 2313716 R 410289 CDS YP_978184.1 121637960 4698660 complement(2314662..2314913) 1 NC_008769.1 hypothetical protein 2314913 4698660 BCG_2094c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978184.1 2314662 R 410289 CDS YP_978185.1 121637961 4697909 complement(2314948..2315919) 1 NC_008769.1 hypothetical protein 2315919 4697909 BCG_2095c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978185.1 2314948 R 410289 CDS YP_978186.1 121637962 4697488 complement(2315920..2316219) 1 NC_008769.1 hypothetical protein 2316219 4697488 BCG_2096c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978186.1 2315920 R 410289 CDS YP_978187.1 121637963 4697496 2316684..2316998 1 NC_008769.1 Differs from Rv2078 by 1aa, G6E; hypothetical protein 2316998 4697496 BCG_2097 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978187.1 2316684 D 410289 CDS YP_978188.1 121637964 4697044 2316980..2318950 1 NC_008769.1 Differs from Rv2079 by 2aa, C47Y, L216P; hypothetical protein 2318950 4697044 BCG_2098 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978188.1 2316980 D 410289 CDS YP_978189.1 121637965 4699298 2318931..2319494 1 NC_008769.1 Differs from Rv2080 by 1aa, A23V; lipoprotein LppJ 2319494 lppJ 4699298 lppJ Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein LppJ YP_978189.1 2318931 D 410289 CDS YP_978190.1 121637966 4698723 complement(2319530..2320141) 1 NC_008769.1 In Mycobacterium bovis, a 3 bp in-frame insertion (*-ggg) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (147 aa versus 146 aa). In Mycobacterium bovis BCG Pasteur, insertion of 11bp or 8bp compared to its homologs in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis leads to a product with a different C-terminal part; hypothetical protein 2320141 4698723 BCG_2100c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978190.1 2319530 R 410289 CDS YP_978191.1 121637967 4697313 2320345..2322432 1 NC_008769.1 Differs from Mb2108 (721 aa) and from Rv2082 (721 aa) by 26 codon in-frame deletion and from Rv2082 by 2aa, A183T, R612L; hypothetical protein 2322432 4697313 BCG_2101 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978191.1 2320345 D 410289 CDS YP_978192.1 121637968 4696438 2322429..2323373 1 NC_008769.1 Differs from Rv2083 by 1aa, V256L; hypothetical protein 2323373 4696438 BCG_2102 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978192.1 2322429 D 410289 CDS YP_978193.1 121637969 4696836 2323366..2324361 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2084 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to an 11 bp insertion (*-ggcgtacacac), splits Rv2084 into 2 parts; hypothetical protein 2324361 4696836 BCG_2103 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978193.1 2323366 D 410289 CDS YP_978194.1 121637970 4695413 2324596..2324901 1 NC_008769.1 hypothetical protein 2324901 4695413 BCG_2105 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978194.1 2324596 D 410289 CDS YP_978195.1 121637971 4698788 2324880..2325485 1 NC_008769.1 hypothetical protein 2325485 4698788 BCG_2106 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978195.1 2324880 D 410289 CDS YP_978196.1 121637972 4698008 2325563..2325793 1 NC_008769.1 hypothetical protein 2325793 4698008 BCG_2107 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978196.1 2325563 D 410289 CDS YP_978197.1 121637973 4697752 2325980..2327749 1 NC_008769.1 transmembrane serine/threonine-protein kinase j pknJ 2327749 pknJ 4697752 pknJ Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane serine/threonine-protein kinase j pknJ YP_978197.1 2325980 D 410289 CDS YP_978198.1 121637974 4697525 complement(2327766..2328893) 1 NC_008769.1 dipeptidase PepE 2328893 pepE 4697525 pepE Mycobacterium bovis BCG str. Pasteur 1173P2 dipeptidase PepE YP_978198.1 2327766 R 410289 CDS YP_978199.1 121637975 4696121 2328942..2330009 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, a 114 bp in-frame deletion leads to a shorter product compared to its ortholog in Mycobacterium tuberculosis strain H37Rv (355 aa versus 393 aa) and a 57 bp in-frame deletion leads to a shorter product compared to its ortholog in Mycobacterium bovis (355 aa versus 374 aa). Difference is due to copy number of tandem motif: DPTSGDPLHPAPPRLRSPL (or variant thereof) near N-terminus. Also differs from Rv2090 by 1aa, L320F; 5'-3' exonuclease 2330009 4696121 BCG_2110 Mycobacterium bovis BCG str. Pasteur 1173P2 5'-3' exonuclease YP_978199.1 2328942 D 410289 CDS YP_978200.1 121637976 4698874 complement(2330013..2330747) 1 NC_008769.1 hypothetical protein 2330747 4698874 BCG_2111c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978200.1 2330013 R 410289 CDS YP_978201.1 121637977 4695437 complement(2330789..2333509) 1 NC_008769.1 Differs from Rv2092c by 1aa, M178T; ATP-dependent DNA helicase helY 2333509 helY 4695437 helY Mycobacterium bovis BCG str. Pasteur 1173P2 ATP-dependent DNA helicase helY YP_978201.1 2330789 R 410289 CDS YP_978202.1 121637978 4695481 complement(2333558..2334484) 1 NC_008769.1 Sec-independent protein translocase transmembrane protein tatC 2334484 tatC 4695481 tatC Mycobacterium bovis BCG str. Pasteur 1173P2 Sec-independent protein translocase transmembrane protein tatC YP_978202.1 2333558 R 410289 CDS YP_978203.1 121637979 4697791 complement(2334501..2334752) 1 NC_008769.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase A 2334752 tatA 4697791 tatA Mycobacterium bovis BCG str. Pasteur 1173P2 twin arginine translocase A YP_978203.1 2334501 R 410289 CDS YP_978204.1 121637980 4697789 complement(2334820..2335770) 1 NC_008769.1 Differs from Mb2122c by 1aa, A267V; hypothetical protein 2335770 4697789 BCG_2115c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978204.1 2334820 R 410289 CDS YP_978205.1 121637981 4698438 complement(2335767..2336765) 1 NC_008769.1 hypothetical protein 2336765 4698438 BCG_2116c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978205.1 2335767 R 410289 CDS YP_978206.1 121637982 4697360 complement(2336774..2338132) 1 NC_008769.1 hypothetical protein 2338132 4697360 BCG_2117c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978206.1 2336774 R 410289 CDS YP_978207.1 121637983 4698890 complement(2338184..2339659) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS36 and PE21 exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur,a single base insertion (*-c) leads to a single product more similar to PE_PGRS36. There is also a 3 bp in-frame deletion (ggc-*); PE-PGRS family protein 2339659 PE_PGRS36 4698890 PE_PGRS36 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_978207.1 2338184 R 410289 CDS YP_978208.1 121637984 4698706 2339842..2341494 1 NC_008769.1 hypothetical protein 2341494 4698706 BCG_2119 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978208.1 2339842 D 410289 CDS YP_978209.1 121637985 4698024 2341693..2344734 1 NC_008769.1 Differs from Rv2101 by 3aa, L462M, Q601P, S652A; helicase helZ 2344734 helZ 4698024 helZ Mycobacterium bovis BCG str. Pasteur 1173P2 helicase helZ YP_978209.1 2341693 D 410289 CDS YP_978210.1 121637986 4695482 2344844..2345560 1 NC_008769.1 hypothetical protein 2345560 4695482 BCG_2121 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978210.1 2344844 D 410289 CDS YP_978211.1 121637987 4698340 complement(2345539..2345973) 1 NC_008769.1 hypothetical protein 2345973 4698340 BCG_2122c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978211.1 2345539 R 410289 CDS YP_978212.1 121637988 4697431 complement(2345980..2346234) 1 NC_008769.1 hypothetical protein 2346234 4697431 BCG_2123c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978212.1 2345980 R 410289 CDS YP_978213.1 121637989 4699051 2347454..2347750 1 NC_008769.1 PE family protein 2347750 PE22 4699051 PE22 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_978213.1 2347454 D 410289 CDS YP_978214.1 121637990 4699378 2347806..2348537 1 NC_008769.1 PPE family protein 2348537 PPE36 4699378 PPE36 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_978214.1 2347806 D 410289 CDS YP_978215.1 121637991 4696451 complement(2349077..2349823) 1 NC_008769.1 Differs from Rv2109c by 2aa, P135R, G182R; proteasome subunit alpha PrcA 2349823 prcA 4696451 prcA Mycobacterium bovis BCG str. Pasteur 1173P2 proteasome subunit alpha PrcA YP_978215.1 2349077 R 410289 CDS YP_978216.1 121637992 4696491 complement(2349820..2350695) 1 NC_008769.1 proteasome subunit beta PrcB 2350695 prcB 4696491 prcB Mycobacterium bovis BCG str. Pasteur 1173P2 proteasome subunit beta PrcB YP_978216.1 2349820 R 410289 CDS YP_978217.1 121637993 4696492 complement(2350692..2350886) 1 NC_008769.1 hypothetical protein 2350886 4696492 BCG_2128c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978217.1 2350692 R 410289 CDS YP_978218.1 121637994 4696509 complement(2350999..2352606) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 57 bp in-frame deletion at the NH2 part, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (535 aa versus 554 aa); hypothetical protein 2352606 4696509 BCG_2129c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978218.1 2350999 R 410289 CDS YP_978219.1 121637995 4696379 2352667..2353860 1 NC_008769.1 Differs from Mb2137 by 1aa, S278L, and from Rv2113 by 1aa, P207T; integral membrane protein 2353860 4696379 BCG_2130 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_978219.1 2352667 D 410289 CDS YP_978220.1 121637996 4698025 2353871..2354494 1 NC_008769.1 hypothetical protein 2354494 4698025 BCG_2131 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978220.1 2353871 D 410289 CDS YP_978221.1 121637997 4698434 complement(2354498..2356327) 1 NC_008769.1 ATPase 2356327 4698434 BCG_2132c Mycobacterium bovis BCG str. Pasteur 1173P2 ATPase YP_978221.1 2354498 R 410289 CDS YP_978222.1 121637998 4697758 2356608..2357177 1 NC_008769.1 lipoprotein lppK 2357177 lppK 4697758 lppK Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppK YP_978222.1 2356608 D 410289 CDS YP_978223.1 121637999 4698724 2357185..2357478 1 NC_008769.1 hypothetical protein 2357478 4698724 BCG_2134 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978223.1 2357185 D 410289 CDS YP_978224.1 121638000 4695596 complement(2357507..2358349) 1 NC_008769.1 RNA methyltransferase 2358349 4695596 BCG_2135c Mycobacterium bovis BCG str. Pasteur 1173P2 RNA methyltransferase YP_978224.1 2357507 R 410289 CDS YP_978225.1 121638001 4699353 2358423..2359259 1 NC_008769.1 hypothetical protein 2359259 4699353 BCG_2136 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978225.1 2358423 D 410289 CDS YP_978226.1 121638002 4695844 complement(2359282..2359764) 1 NC_008769.1 integral membrane protein 2359764 4695844 BCG_2137c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_978226.1 2359282 R 410289 CDS YP_978227.1 121638003 4699083 complement(2359843..2360697) 1 NC_008769.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2360697 hisG 4699083 hisG Mycobacterium bovis BCG str. Pasteur 1173P2 ATP phosphoribosyltransferase YP_978227.1 2359843 R 410289 CDS YP_978228.1 121638004 4696067 complement(2360700..2360981) 1 NC_008769.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase 2360981 hisE 4696067 hisE Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoribosyl-ATP pyrophosphatase YP_978228.1 2360700 R 410289 CDS YP_978229.1 121638005 4696065 2361108..2362502 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 27 bp in-frame deletion leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 473 aa); PPE family protein 2362502 PPE37 4696065 PPE37 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_978229.1 2361108 D 410289 CDS YP_978230.1 121638006 4696452 complement(2362499..2366077) 1 NC_008769.1 Differs from Rv2124c by 1aa, V752I; 5-methyltetrahydrofolate--homocystein methyltransferase MetH 2366077 metH 4696452 metH Mycobacterium bovis BCG str. Pasteur 1173P2 5-methyltetrahydrofolate--homocystein methyltransferase MetH YP_978230.1 2362499 R 410289 CDS YP_978231.1 121638007 4699103 2366303..2367181 1 NC_008769.1 Differs from Rv2125 by 1aa, S33G; hypothetical protein 2367181 4699103 BCG_2142 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978231.1 2366303 D 410289 CDS YP_978232.1 121638008 4699072 complement(2367212..2367982) 1 NC_008769.1 PE-PGRS family protein 2367982 PE_PGRS37 4699072 PE_PGRS37 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_978232.1 2367212 R 410289 CDS YP_978233.1 121638009 4698707 2368626..2370095 1 NC_008769.1 Differs from Rv2127 by 2aa, D9G, S44G; L-asparagine permease ansP1 2370095 ansP1 4698707 ansP1 Mycobacterium bovis BCG str. Pasteur 1173P2 L-asparagine permease ansP1 YP_978233.1 2368626 D 410289 CDS YP_978234.1 121638010 4695930 2370095..2370298 1 NC_008769.1 hypothetical protein 2370298 4695930 BCG_2145 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978234.1 2370095 D 410289 CDS YP_978235.1 121638011 4698134 complement(2370318..2371199) 1 NC_008769.1 short chain dehydrogenase 2371199 4698134 BCG_2146c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_978235.1 2370318 R 410289 CDS YP_978236.1 121638012 4697992 complement(2371225..2372469) 1 NC_008769.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 2372469 cysS2 4697992 cysS2 Mycobacterium bovis BCG str. Pasteur 1173P2 cysteinyl-tRNA synthetase YP_978236.1 2371225 R 410289 CDS YP_978237.1 121638013 4695542 complement(2372527..2373330) 1 NC_008769.1 hypothetical protein 2373330 cysQ 4695542 cysQ Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978237.1 2372527 R 410289 CDS YP_978238.1 121638014 4695464 2373421..2373651 1 NC_008769.1 hypothetical protein 2373651 4695464 BCG_2149 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978238.1 2373421 D 410289 CDS YP_978239.1 121638015 4698114 complement(2373861..2374649) 1 NC_008769.1 hypothetical protein 2374649 4698114 BCG_2150c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978239.1 2373861 R 410289 CDS YP_978240.1 121638016 4699239 complement(2374660..2375247) 1 NC_008769.1 hypothetical protein 2375247 4699239 BCG_2151c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978240.1 2374660 R 410289 CDS YP_978241.1 121638017 4698126 complement(2375311..2376021) 1 NC_008769.1 hypothetical protein 2376021 4698126 BCG_2152c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978241.1 2375311 R 410289 CDS YP_978242.1 121638018 4699319 complement(2376018..2376848) 1 NC_008769.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters UDP disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 2376848 4699319 BCG_2153c Mycobacterium bovis BCG str. Pasteur 1173P2 UDP pyrophosphate phosphatase YP_978242.1 2376018 R 410289 CDS YP_978243.1 121638019 4697084 complement(2376912..2377325) 1 NC_008769.1 hypothetical protein 2377325 4697084 BCG_2154c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978243.1 2376912 R 410289 CDS YP_978244.1 121638020 4697689 2377340..2378416 1 NC_008769.1 Differs from Mb2162 by 3aa, VQV348-350SRF, due to 7bp substitution in latter, tccaggt-gtccagg; lipoprotein LppL 2378416 lppL 4697689 lppL Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein LppL YP_978244.1 2377340 D 410289 CDS YP_978245.1 121638021 4698725 2378730..2379803 1 NC_008769.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 2379803 pyrD 4698725 pyrD Mycobacterium bovis BCG str. Pasteur 1173P2 dihydroorotate dehydrogenase 2 YP_978245.1 2378730 D 410289 CDS YP_978246.1 121638022 4696885 complement(2379808..2380338) 1 NC_008769.1 hypothetical protein 2380338 TB18.6 4696885 TB18.6 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978246.1 2379808 R 410289 CDS YP_978247.1 121638023 4697562 complement(2380386..2381732) 1 NC_008769.1 hypothetical protein 2381732 4697562 BCG_2158c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978247.1 2380386 R 410289 CDS YP_978248.1 121638024 4696749 complement(2382203..2382520) 1 NC_008769.1 hypothetical protein 2382520 4696749 BCG_2159c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978248.1 2382203 R 410289 CDS YP_978249.1 121638025 4696732 2382987..2384045 1 NC_008769.1 hypothetical protein 2384045 4696732 BCG_2160 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978249.1 2382987 D 410289 CDS YP_978250.1 121638026 4696131 complement(2384175..2384531) 1 NC_008769.1 hypothetical protein 2384531 4696131 BCG_2161c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978250.1 2384175 R 410289 CDS YP_978251.1 121638027 4696886 complement(2384626..2385408) 1 NC_008769.1 hypothetical protein 2385408 wag31 4696886 wag31 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978251.1 2384626 R 410289 CDS YP_978252.1 121638028 4697890 complement(2385676..2385966) 1 NC_008769.1 hypothetical protein 2385966 4697890 BCG_2163c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978252.1 2385676 R 410289 CDS YP_978253.1 121638029 4698596 complement(2386128..2386853) 1 NC_008769.1 hypothetical protein 2386853 4698596 BCG_2164c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978253.1 2386128 R 410289 CDS YP_978254.1 121638030 4699048 complement(2386850..2387626) 1 NC_008769.1 hypothetical protein 2387626 4699048 BCG_2165c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978254.1 2386850 R 410289 CDS YP_978255.1 121638031 4698585 complement(2387632..2388384) 1 NC_008769.1 hypothetical protein 2388384 yfiH 4698585 yfiH Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978255.1 2387632 R 410289 CDS YP_978256.1 121638032 4697799 complement(2388395..2389534) 1 NC_008769.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 2389534 ftsZ 4697799 ftsZ Mycobacterium bovis BCG str. Pasteur 1173P2 cell division protein FtsZ YP_978256.1 2388395 R 410289 CDS YP_978257.1 121638033 4698535 complement(2389707..2390651) 1 NC_008769.1 cell division protein ftsQ 2390651 ftsQ 4698535 ftsQ Mycobacterium bovis BCG str. Pasteur 1173P2 cell division protein ftsQ YP_978257.1 2389707 R 410289 CDS YP_978258.1 121638034 4695824 complement(2390648..2392132) 1 NC_008769.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 2392132 murC 4695824 murC Mycobacterium bovis BCG str. Pasteur 1173P2 UDP-N-acetylmuramate--L-alanine ligase YP_978258.1 2390648 R 410289 CDS YP_978259.1 121638035 4698424 complement(2392129..2393361) 1 NC_008769.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDPdiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 2393361 murG 4698424 murG Mycobacterium bovis BCG str. Pasteur 1173P2 UDPdiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_978259.1 2392129 R 410289 CDS YP_978260.1 121638036 4698427 complement(2393358..2394932) 1 NC_008769.1 FtsW-like protein FtsW 2394932 ftsW 4698427 ftsW Mycobacterium bovis BCG str. Pasteur 1173P2 FtsW-like protein FtsW YP_978260.1 2393358 R 410289 CDS YP_978261.1 121638037 4698532 complement(2394944..2396404) 1 NC_008769.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 2396404 murD 4698532 murD Mycobacterium bovis BCG str. Pasteur 1173P2 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_978261.1 2394944 R 410289 CDS YP_978262.1 121638038 4698547 complement(2396406..2397485) 1 NC_008769.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 2397485 mraY 4698547 mraY Mycobacterium bovis BCG str. Pasteur 1173P2 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_978262.1 2396406 R 410289 CDS YP_978263.1 121638039 4697970 complement(2397482..2399014) 1 NC_008769.1 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase MurF 2399014 murF 4697970 murF Mycobacterium bovis BCG str. Pasteur 1173P2 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase MurF YP_978263.1 2397482 R 410289 CDS YP_978264.1 121638040 4698426 complement(2399011..2400618) 1 NC_008769.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 2400618 murE 4698426 murE Mycobacterium bovis BCG str. Pasteur 1173P2 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_978264.1 2399011 R 410289 CDS YP_978265.1 121638041 4698425 complement(2400641..2401675) 1 NC_008769.1 hypothetical protein 2401675 4698425 BCG_2176c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978265.1 2400641 R 410289 CDS YP_978266.1 121638042 4698299 complement(2401672..2402292) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2160A and Rv2160c exist as 2 genes with an overlap region between them. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a 4 bp insertion (*-ggaa) leads to a single product; hypothetical protein 2402292 4698299 BCG_2177c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978266.1 2401672 R 410289 CDS YP_978267.1 121638043 4695649 complement(2402285..2403151) 1 NC_008769.1 hypothetical protein 2403151 4695649 BCG_2178c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978267.1 2402285 R 410289 CDS YP_978268.1 121638044 4698464 complement(2403254..2404726) 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, in-frame deletions of 108 bp and 18 bp leads to a shorter product than in Mycobacterium tuberculosis strain H37Rv (490 aa versus 532 aa); PE-PGRS family protein 2404726 PE_PGRS38 4698464 PE_PGRS38 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_978268.1 2403254 R 410289 CDS YP_978269.1 121638045 4698708 complement(2404936..2406975) 1 NC_008769.1 penicillin-binding membrane protein pbpB 2406975 pbpB 4698708 pbpB Mycobacterium bovis BCG str. Pasteur 1173P2 penicillin-binding membrane protein pbpB YP_978269.1 2404936 R 410289 CDS YP_978270.1 121638046 4698834 complement(2406972..2408126) 1 NC_008769.1 Differs from Mb2188c by 1aa, V202A; proline rich membrane protein 2408126 4698834 BCG_2181c Mycobacterium bovis BCG str. Pasteur 1173P2 proline rich membrane protein YP_978270.1 2406972 R 410289 CDS YP_978271.1 121638047 4696183 complement(2408123..2409313) 1 NC_008769.1 S-adenosyl-methyltransferase 2409313 mraW 4696183 mraW Mycobacterium bovis BCG str. Pasteur 1173P2 S-adenosyl-methyltransferase YP_978271.1 2408123 R 410289 CDS YP_978272.1 121638048 4696788 complement(2409315..2409746) 1 NC_008769.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 2409746 4696788 BCG_2183c Mycobacterium bovis BCG str. Pasteur 1173P2 cell division protein MraZ YP_978272.1 2409315 R 410289 CDS YP_978273.1 121638049 4696671 complement(2410095..2410499) 1 NC_008769.1 hypothetical protein 2410499 4696671 BCG_2184c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978273.1 2410095 R 410289 CDS YP_978274.1 121638050 4698174 2410765..2411385 1 NC_008769.1 hypothetical protein 2411385 4698174 BCG_2185 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978274.1 2410765 D 410289 CDS YP_978275.1 121638051 4697733 2411481..2412164 1 NC_008769.1 lipoprotein lppM 2412164 lppM 4697733 lppM Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppM YP_978275.1 2411481 D 410289 CDS YP_978276.1 121638052 4698726 complement(2412161..2413066) 1 NC_008769.1 hypothetical protein 2413066 4698726 BCG_2187c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978276.1 2412161 R 410289 CDS YP_978277.1 121638053 4697575 2413377..2414435 1 NC_008769.1 geranylgeranyl pyrophosphate synthetase idsA2 2414435 idsA2 4697575 idsA2 Mycobacterium bovis BCG str. Pasteur 1173P2 geranylgeranyl pyrophosphate synthetase idsA2 YP_978277.1 2413377 D 410289 CDS YP_978278.1 121638054 4696222 2414439..2416142 1 NC_008769.1 Differs from Rv2174 and Mb2196 at 3'-end owing to frameshift due to 1 bp insertion (t) at position corresponding to H37Rv coordinates 2437401-2437402, and from Rv2174 by 1aa, S451A.; hypothetical protein 2416142 4696222 BCG_2189 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978278.1 2414439 D 410289 CDS YP_978279.1 121638055 4698255 complement(2415977..2416417) 1 NC_008769.1 Differs from Rv2175c by 1aa, L17P; regulatory protein 2416417 4698255 BCG_2190c Mycobacterium bovis BCG str. Pasteur 1173P2 regulatory protein YP_978279.1 2415977 R 410289 CDS YP_978280.1 121638056 4698488 2416472..2417671 1 NC_008769.1 Differs from Rv2176 by 1aa, A52S; transmembrane serine/threonine-protein kinase L pknL 2417671 pknL 4698488 pknL Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane serine/threonine-protein kinase L pknL YP_978280.1 2416472 D 410289 CDS YP_978281.1 121638057 4696188 complement(2417813..2418478) 1 NC_008769.1 Differs from Rv2177c by 1aa, K115T; transposase 2418478 4696188 BCG_2192c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_978281.1 2417813 R 410289 CDS YP_978282.1 121638058 4698650 complement(2418863..2420251) 1 NC_008769.1 Differs from Rv2178c by 1aa, E265D; 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase 2420251 aroG 4698650 aroG Mycobacterium bovis BCG str. Pasteur 1173P2 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase YP_978282.1 2418863 R 410289 CDS YP_978283.1 121638059 4695761 complement(2420342..2420848) 1 NC_008769.1 hypothetical protein 2420848 4695761 BCG_2194c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978283.1 2420342 R 410289 CDS YP_978284.1 121638060 4699065 complement(2420858..2421745) 1 NC_008769.1 Differs from Rv2180c by 1aa, T156P; integral membrane protein 2421745 4699065 BCG_2195c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_978284.1 2420858 R 410289 CDS YP_978285.1 121638061 4696677 2421833..2423116 1 NC_008769.1 integral membrane protein 2423116 4696677 BCG_2196 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_978285.1 2421833 D 410289 CDS YP_978286.1 121638062 4698317 complement(2423117..2423860) 1 NC_008769.1 1-acylglycerol-3-phosphate O-acyltransferase 2423860 4698317 BCG_2197c Mycobacterium bovis BCG str. Pasteur 1173P2 1-acylglycerol-3-phosphate O-acyltransferase YP_978286.1 2423117 R 410289 CDS YP_978287.1 121638063 4699145 complement(2423946..2424341) 1 NC_008769.1 hypothetical protein 2424341 4699145 BCG_2198c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978287.1 2423946 R 410289 CDS YP_978288.1 121638064 4695760 complement(2424338..2425477) 1 NC_008769.1 hypothetical protein 2425477 4695760 BCG_2199c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978288.1 2424338 R 410289 CDS YP_978289.1 121638065 4698798 complement(2425597..2426031) 1 NC_008769.1 hypothetical protein 2426031 TB16.3 4698798 TB16.3 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978289.1 2425597 R 410289 CDS YP_978290.1 121638066 4697560 complement(2426136..2426525) 1 NC_008769.1 hypothetical protein 2426525 4697560 BCG_2201c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978290.1 2426136 R 410289 CDS YP_978291.1 121638067 4696867 2426691..2427203 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, fadD15 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to single base deletion (t-*) splits fadD15 into 2 parts; hypothetical protein 2427203 4696867 BCG_2202 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978291.1 2426691 D 410289 CDS YP_978292.1 121638068 4699321 2426966..2428492 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, fadD15 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to single base deletion (t-*) splits fadD15 into 2 parts. Differs from Rv2187 by 2aa, I8T, E287G; long-chain-fatty-acid-CoA ligase fadD15 2428492 fadD15 4699321 fadD15 Mycobacterium bovis BCG str. Pasteur 1173P2 long-chain-fatty-acid-CoA ligase fadD15 YP_978292.1 2426966 D 410289 CDS YP_978293.1 121638069 4698016 complement(2428523..2429680) 1 NC_008769.1 hypothetical protein 2429680 4698016 BCG_2204c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978293.1 2428523 R 410289 CDS YP_978294.1 121638070 4698620 complement(2429777..2430550) 1 NC_008769.1 hypothetical protein 2430550 4698620 BCG_2205c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978294.1 2429777 R 410289 CDS YP_978295.1 121638071 4696133 complement(2430645..2431802) 1 NC_008769.1 hypothetical protein 2431802 4696133 BCG_2206c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978295.1 2430645 R 410289 CDS YP_978296.1 121638072 4696738 2432349..2434286 1 NC_008769.1 contains 3'-5'exonuclease domain; hypothetical protein 2434286 4696738 BCG_2207 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978296.1 2432349 D 410289 CDS YP_978297.1 121638073 4698953 complement(2434161..2435273) 1 NC_008769.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 2435273 trpD 4698953 trpD Mycobacterium bovis BCG str. Pasteur 1173P2 anthranilate phosphoribosyltransferase YP_978297.1 2434161 R 410289 CDS YP_978298.1 121638074 4696872 2435431..2436042 1 NC_008769.1 cytochrome C oxidase (subunit III) ctaE 2436042 ctaE 4696872 ctaE Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome C oxidase (subunit III) ctaE YP_978298.1 2435431 D 410289 CDS YP_978299.1 121638075 4697651 2436083..2436925 1 NC_008769.1 ubiquinol-cytochrome C reductase QcrC (cytochrome C subunit) 2436925 qcrC 4697651 qcrC Mycobacterium bovis BCG str. Pasteur 1173P2 ubiquinol-cytochrome C reductase QcrC (cytochrome C subunit) YP_978299.1 2436083 D 410289 CDS YP_978300.1 121638076 4695434 2436922..2438211 1 NC_008769.1 Differs from Rv2195 by 1aa, I281M; Rieske iron-sulfur protein QcrA 2438211 qcrA 4695434 qcrA Mycobacterium bovis BCG str. Pasteur 1173P2 Rieske iron-sulfur protein QcrA YP_978300.1 2436922 D 410289 CDS YP_978301.1 121638077 4695432 2438208..2439857 1 NC_008769.1 ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) 2439857 qcrB 4695432 qcrB Mycobacterium bovis BCG str. Pasteur 1173P2 ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) YP_978301.1 2438208 D 410289 CDS YP_978302.1 121638078 4695433 complement(2440148..2440792) 1 NC_008769.1 Differs from Rv2197c by 1aa, S202A; hypothetical protein 2440792 4695433 BCG_2213c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978302.1 2440148 R 410289 CDS YP_978303.1 121638079 4697774 complement(2440792..2441691) 1 NC_008769.1 membrane protein mmpS3 2441691 mmpS3 4697774 mmpS3 Mycobacterium bovis BCG str. Pasteur 1173P2 membrane protein mmpS3 YP_978303.1 2440792 R 410289 CDS YP_978304.1 121638080 4697492 complement(2441877..2442296) 1 NC_008769.1 hypothetical protein 2442296 4697492 BCG_2215c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978304.1 2441877 R 410289 CDS YP_978305.1 121638081 4698871 complement(2442304..2443395) 1 NC_008769.1 transmembrane cytochrome C oxidase (subunit II) ctaC 2443395 ctaC 4698871 ctaC Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane cytochrome C oxidase (subunit II) ctaC YP_978305.1 2442304 R 410289 CDS YP_978306.1 121638082 4697753 2443641..2445599 1 NC_008769.1 asparagine synthetase AsnB 2445599 asnB 4697753 asnB Mycobacterium bovis BCG str. Pasteur 1173P2 asparagine synthetase AsnB YP_978306.1 2443641 D 410289 CDS YP_978307.1 121638083 4696535 complement(2445697..2446671) 1 NC_008769.1 adenosine kinase 2446671 adoK 4696535 adoK Mycobacterium bovis BCG str. Pasteur 1173P2 adenosine kinase YP_978307.1 2445697 R 410289 CDS YP_978308.1 121638084 4695687 2446875..2447567 1 NC_008769.1 hypothetical protein 2447567 4695687 BCG_2219 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978308.1 2446875 D 410289 CDS YP_978309.1 121638085 4696110 complement(2447575..2447931) 1 NC_008769.1 hypothetical protein 2447931 4696110 BCG_2220c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978309.1 2447575 R 410289 CDS YP_978310.1 121638086 4698166 complement(2448031..2449107) 1 NC_008769.1 hypothetical protein 2449107 4698166 BCG_2221c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978310.1 2448031 R 410289 CDS YP_978311.1 121638087 4698597 2449266..2449976 1 NC_008769.1 hypothetical protein 2449976 4698597 BCG_2222 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978311.1 2449266 D 410289 CDS YP_978312.1 121638088 4698703 2450055..2451140 1 NC_008769.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2451140 cobT 4698703 cobT Mycobacterium bovis BCG str. Pasteur 1173P2 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase YP_978312.1 2450055 D 410289 CDS YP_978313.1 121638089 4697942 2451137..2451886 1 NC_008769.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 2451886 cobS 4697942 cobS Mycobacterium bovis BCG str. Pasteur 1173P2 cobalamin synthase YP_978313.1 2451137 D 410289 CDS YP_978314.1 121638090 4697928 2452044..2453582 1 NC_008769.1 integral membrane protein 2453582 4697928 BCG_2225 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_978314.1 2452044 D 410289 CDS YP_978315.1 121638091 4696760 complement(2453508..2454614) 1 NC_008769.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 2454614 ilvE 4696760 ilvE Mycobacterium bovis BCG str. Pasteur 1173P2 branched-chain amino acid aminotransferase YP_978315.1 2453508 R 410289 CDS YP_978316.1 121638092 4699342 complement(2454686..2455825) 1 NC_008769.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 2455825 gcvT 4699342 gcvT Mycobacterium bovis BCG str. Pasteur 1173P2 glycine cleavage system aminomethyltransferase T YP_978316.1 2454686 R 410289 CDS YP_978317.1 121638093 4698645 2455834..2456970 1 NC_008769.1 hypothetical protein 2456970 4698645 BCG_2228 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978317.1 2455834 D 410289 CDS YP_978318.1 121638094 4699189 2456982..2458529 1 NC_008769.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 2458529 pepB 4699189 pepB Mycobacterium bovis BCG str. Pasteur 1173P2 leucyl aminopeptidase YP_978318.1 2456982 D 410289 CDS YP_978319.1 121638095 4696119 complement(2458567..2460345) 1 NC_008769.1 short chain dehydrogenase 2460345 ephD 4696119 ephD Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_978319.1 2458567 R 410289 CDS YP_978320.1 121638096 4698294 2460609..2462270 1 NC_008769.1 Differs from Rv2215 and Mb2238 by 1aa, V517L; dihydrolipoamide acetyltransferase 2462270 dlaT 4698294 dlaT Mycobacterium bovis BCG str. Pasteur 1173P2 dihydrolipoamide acetyltransferase YP_978320.1 2460609 D 410289 CDS YP_978321.1 121638097 4696602 2462270..2463175 1 NC_008769.1 hypothetical protein 2463175 4696602 BCG_2232 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978321.1 2462270 D 410289 CDS YP_978322.1 121638098 4698303 2463228..2463920 1 NC_008769.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 2463920 lipB 4698303 lipB Mycobacterium bovis BCG str. Pasteur 1173P2 lipoate-protein ligase B YP_978322.1 2463228 D 410289 CDS YP_978323.1 121638099 4698687 2463917..2464852 1 NC_008769.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 2464852 lipA 4698687 lipA Mycobacterium bovis BCG str. Pasteur 1173P2 lipoyl synthase YP_978323.1 2463917 D 410289 CDS YP_978324.1 121638100 4698686 2464879..2465631 1 NC_008769.1 Differs from Rv2219 by 1aa, L74F; hypothetical protein 2465631 4698686 BCG_2235 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978324.1 2464879 D 410289 CDS YP_978325.1 121638101 4697428 complement(2465638..2466060) 1 NC_008769.1 hypothetical protein 2466060 4697428 BCG_2236c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978325.1 2465638 R 410289 CDS YP_978326.1 121638102 4698818 2466259..2467695 1 NC_008769.1 glutamine synthetase glnA1 2467695 glnA1 4698818 glnA1 Mycobacterium bovis BCG str. Pasteur 1173P2 glutamine synthetase glnA1 YP_978326.1 2466259 D 410289 CDS YP_978327.1 121638103 4696209 complement(2468013..2470997) 1 NC_008769.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 2470997 glnE 4696209 glnE Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_978327.1 2468013 R 410289 CDS YP_978328.1 121638104 4697946 complement(2471046..2472386) 1 NC_008769.1 glutamine synthetase glnA2 2472386 glnA2 4697946 glnA2 Mycobacterium bovis BCG str. Pasteur 1173P2 glutamine synthetase glnA2 YP_978328.1 2471046 R 410289 CDS YP_978329.1 121638105 4696210 complement(2472481..2474043) 1 NC_008769.1 Differs from Rv2223c and Mb2247c by 1aa, S307A; protease 2474043 4696210 BCG_2240c Mycobacterium bovis BCG str. Pasteur 1173P2 protease YP_978329.1 2472481 R 410289 CDS YP_978330.1 121638106 4699161 complement(2474105..2475667) 1 NC_008769.1 protease 2475667 4699161 BCG_2241c Mycobacterium bovis BCG str. Pasteur 1173P2 protease YP_978330.1 2474105 R 410289 CDS YP_978331.1 121638107 4699049 2476386..2477231 1 NC_008769.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 2477231 panB 4699049 panB Mycobacterium bovis BCG str. Pasteur 1173P2 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_978331.1 2476386 D 410289 CDS YP_978332.1 121638108 4695407 2477476..2479017 1 NC_008769.1 Differs from Rv2226 and Mb2250 by 1aa, N299D and G31D, respectively; hypothetical protein 2479017 4695407 BCG_2243 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978332.1 2477476 D 410289 CDS YP_978333.1 121638109 4698574 2479575..2479895 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2227 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 1 bp to 2 bp substitution (t-cc) splits Rv2227 in two parts; hypothetical protein 2479895 4698574 BCG_2244 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978333.1 2479575 D 410289 CDS YP_978334.1 121638110 4695992 2479903..2480277 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2227 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 1 bp to 2 bp substitution (t-cc) splits Rv2227 in two parts; hypothetical protein 2480277 4695992 BCG_2245 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978334.1 2479903 D 410289 CDS YP_978335.1 121638111 4697138 complement(2480289..2481383) 1 NC_008769.1 bifunctional RNase H/acid phosphatase 2481383 4697138 BCG_2246c Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional RNase H/acid phosphatase YP_978335.1 2480289 R 410289 CDS YP_978336.1 121638112 4697424 complement(2481380..2482117) 1 NC_008769.1 Differs from Rv2229c by 1aa, Q239R; hypothetical protein 2482117 4697424 BCG_2247c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978336.1 2481380 R 410289 CDS YP_978337.1 121638113 4696829 complement(2482114..2483253) 1 NC_008769.1 hypothetical protein 2483253 4696829 BCG_2248c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978337.1 2482114 R 410289 CDS YP_978338.1 121638114 4695857 complement(2483250..2484344) 1 NC_008769.1 hypothetical protein 2484344 cobC 4695857 cobC Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978338.1 2483250 R 410289 CDS YP_978339.1 121638115 4698830 2484923..2485798 1 NC_008769.1 hypothetical protein 2485798 4698830 BCG_2250 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978339.1 2484923 D 410289 CDS YP_978340.1 121638116 4697319 2485791..2486282 1 NC_008769.1 phosphotyrosine protein phosphatase ptpA 2486282 ptpA 4697319 ptpA Mycobacterium bovis BCG str. Pasteur 1173P2 phosphotyrosine protein phosphatase ptpA YP_978340.1 2485791 D 410289 CDS YP_978341.1 121638117 4697318 2486282..2487097 1 NC_008769.1 hypothetical protein 2487097 4697318 BCG_2252 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978341.1 2486282 D 410289 CDS YP_978342.1 121638118 4696413 complement(2487079..2488020) 1 NC_008769.1 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group; cobalamin biosynthesis protein 2488020 cobD 4696413 cobD Mycobacterium bovis BCG str. Pasteur 1173P2 cobalamin biosynthesis protein YP_978342.1 2487079 R 410289 CDS YP_978343.1 121638119 4698693 2488134..2488901 1 NC_008769.1 hypothetical protein 2488901 4698693 BCG_2254 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978343.1 2488134 D 410289 CDS YP_978344.1 121638120 4696868 complement(2489360..2489821) 1 NC_008769.1 peroxiredoxin AhpE 2489821 ahpE 4696868 ahpE Mycobacterium bovis BCG str. Pasteur 1173P2 peroxiredoxin AhpE YP_978344.1 2489360 R 410289 CDS YP_978345.1 121638121 4696994 complement(2489821..2490297) 1 NC_008769.1 hypothetical protein 2490297 4696994 BCG_2256c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978345.1 2489821 R 410289 CDS YP_978346.1 121638122 4695877 complement(2490335..2491132) 1 NC_008769.1 Differs from Rv2240c by 1aa, K259T; hypothetical protein 2491132 4695877 BCG_2257c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978346.1 2490335 R 410289 CDS YP_978347.1 121638123 4697781 2491184..2493889 1 NC_008769.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 2493889 aceE 4697781 aceE Mycobacterium bovis BCG str. Pasteur 1173P2 pyruvate dehydrogenase subunit E1 YP_978347.1 2491184 D 410289 CDS YP_978348.1 121638124 4698981 2493949..2495193 1 NC_008769.1 Differs from Rv2242 and Mb2266 by 1aa, T363A; hypothetical protein 2495193 4698981 BCG_2259 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978348.1 2493949 D 410289 CDS YP_978349.1 121638125 4697871 2495432..2496340 1 NC_008769.1 malonyl CoA-ACP transacylase 2496340 fabD 4697871 fabD Mycobacterium bovis BCG str. Pasteur 1173P2 malonyl CoA-ACP transacylase YP_978349.1 2495432 D 410289 CDS YP_978350.1 121638126 4698122 2496416..2496763 1 NC_008769.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 2496763 acpP 4698122 acpP Mycobacterium bovis BCG str. Pasteur 1173P2 acyl carrier protein YP_978350.1 2496416 D 410289 CDS YP_978351.1 121638127 4696908 2496760..2498010 1 NC_008769.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 2498010 kasA 4696908 kasA Mycobacterium bovis BCG str. Pasteur 1173P2 3-oxoacyl-ACP synthase YP_978351.1 2496760 D 410289 CDS YP_978352.1 121638128 4697349 2498041..2499357 1 NC_008769.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 2499357 kasB 4697349 kasB Mycobacterium bovis BCG str. Pasteur 1173P2 3-oxoacyl-ACP synthase YP_978352.1 2498041 D 410289 CDS YP_978353.1 121638129 4697350 2499388..2500809 1 NC_008769.1 acetyl/propionyl CoA carboxylase subunit beta 2500809 accD6 4697350 accD6 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl/propionyl CoA carboxylase subunit beta YP_978353.1 2499388 D 410289 CDS YP_978354.1 121638130 4698892 2500917..2501321 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium tuberculosis, Rv2248 and Mb2272 exist as single gene. In Mycobacterium bovis BCG Pasteur, the ortholog is split into two parts owing to single base insertion in G-string (-g) at position equivalent to Mycobacterium tuberculosis position 2522481-2522482; hypothetical protein 2501321 4698892 BCG_2265 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978354.1 2500917 D 410289 CDS YP_978355.1 121638131 4696414 2501029..2501733 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium tuberculosis, Rv2248 and Mb2272 exist as single gene. In Mycobacterium bovis BCG Pasteur, the ortholog is split into two parts owing to single base insertion in G-string (-g) at position equivalent to Mycobacterium tuberculosis position 2522481-2522482; hypothetical protein 2501733 4696414 BCG_2266 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978355.1 2501029 D 410289 CDS YP_978356.1 121638132 4697353 complement(2501802..2503352) 1 NC_008769.1 glycerol-3-phosphate dehydrogenase glpd1 2503352 glpD1 4697353 glpD1 Mycobacterium bovis BCG str. Pasteur 1173P2 glycerol-3-phosphate dehydrogenase glpd1 YP_978356.1 2501802 R 410289 CDS YP_978357.1 121638133 4697768 complement(2503346..2503915) 1 NC_008769.1 Differs from Mb2274c by 1aa, D68A; transcriptional regulatory protein 2503915 4697768 BCG_2268c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_978357.1 2503346 R 410289 CDS YP_978358.1 121638134 4696843 2503963..2505552 1 NC_008769.1 In Mycobacterium tuberculosis H37Rv, Rv2250A and Rv2251 exist as 2 genes with an overlap region between them. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base deletion (g-*) leads to a single product; flavoprotein 2505552 4696843 BCG_2269 Mycobacterium bovis BCG str. Pasteur 1173P2 flavoprotein YP_978358.1 2503963 D 410289 CDS YP_978359.1 121638135 4697305 2505549..2506478 1 NC_008769.1 involved in the biosynthesis of phosphatidylinositol mannosides (PIMs); the enzyme from Mycobacterium tuberculosis can phosphorylate a variety of amphipathic lipids; diacylglycerol kinase 2506478 4697305 BCG_2270 Mycobacterium bovis BCG str. Pasteur 1173P2 diacylglycerol kinase YP_978359.1 2505549 D 410289 CDS YP_978360.1 121638136 4697420 2506544..2507047 1 NC_008769.1 hypothetical protein 2507047 4697420 BCG_2271 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978360.1 2506544 D 410289 CDS YP_978361.1 121638137 4695918 complement(2507080..2507535) 1 NC_008769.1 Differs from Rv2254c by 1aa, V68A; hypothetical protein 2507535 4695918 BCG_2272c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978361.1 2507080 R 410289 CDS YP_978362.1 121638138 4697311 complement(2507540..2507734) 1 NC_008769.1 hypothetical protein 2507734 4697311 BCG_2273c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978362.1 2507540 R 410289 CDS YP_978363.1 121638139 4695753 complement(2507901..2508434) 1 NC_008769.1 Differs from Rv2256c by 1aa, G26A; hypothetical protein 2508434 4695753 BCG_2274c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978363.1 2507901 R 410289 CDS YP_978364.1 121638140 4696442 complement(2508564..2509382) 1 NC_008769.1 hypothetical protein 2509382 4696442 BCG_2275c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978364.1 2508564 R 410289 CDS YP_978365.1 121638141 4695850 complement(2509396..2510457) 1 NC_008769.1 transcriptional regulatory protein 2510457 4695850 BCG_2276c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_978365.1 2509396 R 410289 CDS YP_978366.1 121638142 4695899 2510699..2511784 1 NC_008769.1 zinc-dependent alcohol dehydrogenase AdhE2 2511784 adhE2 4695899 adhE2 Mycobacterium bovis BCG str. Pasteur 1173P2 zinc-dependent alcohol dehydrogenase AdhE2 YP_978366.1 2510699 D 410289 CDS YP_978367.1 121638143 4697167 2511784..2512419 1 NC_008769.1 hypothetical protein 2512419 4697167 BCG_2278 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978367.1 2511784 D 410289 CDS YP_978368.1 121638144 4696839 complement(2512496..2514004) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2262c and Rv2261c exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 2 bp deletion (ct-*) results in a single product; hypothetical protein 2514004 4696839 BCG_2279c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978368.1 2512496 R 410289 CDS YP_978369.1 121638145 4696555 2514093..2515046 1 NC_008769.1 short chain dehydrogenase 2515046 4696555 BCG_2280 Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_978369.1 2514093 D 410289 CDS YP_978370.1 121638146 4696334 complement(2515024..2516802) 1 NC_008769.1 hypothetical protein 2516802 4696334 BCG_2281c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978370.1 2515024 R 410289 CDS YP_978371.1 121638147 4696428 2517152..2518381 1 NC_008769.1 hypothetical protein 2518381 4696428 BCG_2282 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978371.1 2517152 D 410289 CDS YP_978372.1 121638148 4695374 2518556..2519842 1 NC_008769.1 cytochrome P450 124 CYP124 2519842 cyp124 4695374 cyp124 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome P450 124 CYP124 YP_978372.1 2518556 D 410289 CDS YP_978373.1 121638149 4696355 complement(2520096..2521262) 1 NC_008769.1 hypothetical protein 2521262 4696355 BCG_2284c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978373.1 2520096 R 410289 CDS YP_978374.1 121638150 4697817 complement(2521259..2522728) 1 NC_008769.1 Differs from Rv2268c and Mb2291c by 1aa, F203L; cytochrome P450 128 cyp128 2522728 cyp128 4697817 cyp128 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome P450 128 cyp128 YP_978374.1 2521259 R 410289 CDS YP_978375.1 121638151 4696664 complement(2522741..2523073) 1 NC_008769.1 hypothetical protein 2523073 4696664 BCG_2286c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978375.1 2522741 R 410289 CDS YP_978376.1 121638152 4697304 2523150..2523677 1 NC_008769.1 Differs from Mb2293 by 1aa, P152L; lipoprotein lppN 2523677 lppN 4697304 lppN Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppN YP_978376.1 2523150 D 410289 CDS YP_978377.1 121638153 4698727 2523784..2524083 1 NC_008769.1 hypothetical protein 2524083 4698727 BCG_2288 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978377.1 2523784 D 410289 CDS YP_978378.1 121638154 4697007 2524189..2524557 1 NC_008769.1 hypothetical protein 2524557 4697007 BCG_2289 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978378.1 2524189 D 410289 CDS YP_978379.1 121638155 4695938 2524554..2524883 1 NC_008769.1 hypothetical protein 2524883 4695938 BCG_2290 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978379.1 2524554 D 410289 CDS YP_978380.1 121638156 4695367 complement(2524940..2525257) 1 NC_008769.1 Differs from Rv2274c by 1aa, M33I; hypothetical protein 2525257 4695367 BCG_2291c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978380.1 2524940 R 410289 CDS YP_978381.1 121638157 4696639 2525335..2526204 1 NC_008769.1 Differs from Rv2275 and Mb2298 by 1aa, A261E; hypothetical protein 2526204 4696639 BCG_2292 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978381.1 2525335 D 410289 CDS YP_978382.1 121638158 4699163 2526201..2527391 1 NC_008769.1 cytochrome P450 121 CYP121 2527391 cyp121 4699163 cyp121 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome P450 121 CYP121 YP_978382.1 2526201 D 410289 CDS YP_978383.1 121638159 4697119 complement(2527576..2528475) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 1358 bp deletion containing an IS6110 sequence, disrupts the 5' start of Rv2277c resulting in a slightly shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (299 aa versus 301 aa). Differs from Mb2300c by 1aa; glycerolphosphodiesterase 2528475 4697119 BCG_2294c Mycobacterium bovis BCG str. Pasteur 1173P2 glycerolphosphodiesterase YP_978383.1 2527576 R 410289 CDS YP_978384.1 121638160 4698568 2528654..2530033 1 NC_008769.1 dehydrogenase 2530033 4698568 BCG_2295 Mycobacterium bovis BCG str. Pasteur 1173P2 dehydrogenase YP_978384.1 2528654 D 410289 CDS YP_978385.1 121638161 4697662 2530267..2531925 1 NC_008769.1 phosphate-transport permease PitB 2531925 pitB 4697662 pitB Mycobacterium bovis BCG str. Pasteur 1173P2 phosphate-transport permease PitB YP_978385.1 2530267 D 410289 CDS YP_978386.1 121638162 4699307 complement(2532032..2532970) 1 NC_008769.1 LysR family transcriptional regulator 2532970 4699307 BCG_2297c Mycobacterium bovis BCG str. Pasteur 1173P2 LysR family transcriptional regulator YP_978386.1 2532032 R 410289 CDS YP_978387.1 121638163 4699037 2533035..2533229 1 NC_008769.1 hypothetical protein 2533229 4699037 BCG_2298 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978387.1 2533035 D 410289 CDS YP_978388.1 121638164 4695474 2533239..2534534 1 NC_008769.1 esterase LipM 2534534 lipM 4695474 lipM Mycobacterium bovis BCG str. Pasteur 1173P2 esterase LipM YP_978388.1 2533239 D 410289 CDS YP_978389.1 121638165 4698634 2534567..2535904 1 NC_008769.1 hypothetical protein 2535904 4698634 BCG_2300 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978389.1 2534567 D 410289 CDS YP_978390.1 121638166 4696078 complement(2535971..2536234) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2286c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, an in-frame stop codon due to a single base transition (c-t) splits Rv2286c into 2 parts; hypothetical protein 2536234 4696078 BCG_2301c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978390.1 2535971 R 410289 CDS YP_978391.1 121638167 4698040 complement(2536262..2536663) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2286c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base transition (c-t) splits Rv2286c into 2 parts; hypothetical protein 2536663 4698040 BCG_2302c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978391.1 2536262 R 410289 CDS YP_978392.1 121638168 4696053 2536797..2538425 1 NC_008769.1 integral membrane transport protein YjcE 2538425 yjcE 4696053 yjcE Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane transport protein YjcE YP_978392.1 2536797 D 410289 CDS YP_978393.1 121638169 4697800 2538422..2538799 1 NC_008769.1 hypothetical protein 2538799 4697800 BCG_2304 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978393.1 2538422 D 410289 CDS YP_978394.1 121638170 4695834 2538769..2539551 1 NC_008769.1 CDP-diacylglycerol pyrophosphatase 2539551 cdh 4695834 cdh Mycobacterium bovis BCG str. Pasteur 1173P2 CDP-diacylglycerol pyrophosphatase YP_978394.1 2538769 D 410289 CDS YP_978395.1 121638171 4696063 2539693..2539848 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2290 exists as a single gene. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (c-*), splits lppO into 2 parts, lppOa and lppOb; lipoprotein lppOa 2539848 lppOa 4696063 lppOa Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppOa YP_978395.1 2539693 D 410289 CDS YP_978396.1 121638172 4695919 2539842..2540207 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2290 exists as a single gene. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (c-*), splits lppO into 2 parts, lppOa and lppOb; lipoprotein lppOb 2540207 lppOb 4695919 lppOb Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppOb YP_978396.1 2539842 D 410289 CDS YP_978397.1 121638173 4695920 2540267..2541121 1 NC_008769.1 In Mycobacterium bovis, truncation at the 5' start due to a 2 bp deletion (tg-*), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG Pasteur (256 aa versus 284 aa). Differs from Rv2291 by 1aa, A262E; thiosulfate sulfurtransferase SseB 2541121 sseB 4695920 sseB Mycobacterium bovis BCG str. Pasteur 1173P2 thiosulfate sulfurtransferase SseB YP_978397.1 2540267 D 410289 CDS YP_978398.1 121638174 4696754 complement(2541122..2542126) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2293c and Rv2292c exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base insertion (*-g) results in a single product; hypothetical protein 2542126 4696754 BCG_2309c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978398.1 2541122 R 410289 CDS YP_978399.1 121638175 4696185 2542421..2543644 1 NC_008769.1 aminotransferase 2543644 4696185 BCG_2310 Mycobacterium bovis BCG str. Pasteur 1173P2 aminotransferase YP_978399.1 2542421 D 410289 CDS YP_978400.1 121638176 4697185 2543867..2544505 1 NC_008769.1 hypothetical protein 2544505 4697185 BCG_2311 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978400.1 2543867 D 410289 CDS YP_978401.1 121638177 4697631 2544599..2545501 1 NC_008769.1 haloalkane dehalogenase 2545501 4697631 BCG_2312 Mycobacterium bovis BCG str. Pasteur 1173P2 haloalkane dehalogenase YP_978401.1 2544599 D 410289 CDS YP_978402.1 121638178 4698133 2545533..2545985 1 NC_008769.1 hypothetical protein 2545985 4698133 BCG_2313 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978402.1 2545533 D 410289 CDS YP_978403.1 121638179 4696790 2546177..2547148 1 NC_008769.1 hypothetical protein 2547148 4696790 BCG_2314 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978403.1 2546177 D 410289 CDS YP_978404.1 121638180 4696718 complement(2547154..2549097) 1 NC_008769.1 molecular chaperone; heat shock protein 90 2549097 htpG 4696718 htpG Mycobacterium bovis BCG str. Pasteur 1173P2 heat shock protein 90 YP_978404.1 2547154 R 410289 CDS YP_978405.1 121638181 4696303 complement(2549171..2550103) 1 NC_008769.1 hypothetical protein 2550103 4696303 BCG_2316c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978405.1 2549171 R 410289 CDS YP_978406.1 121638182 4697109 2550110..2550802 1 NC_008769.1 cutinase cut2 2550802 cut2 4697109 cut2 Mycobacterium bovis BCG str. Pasteur 1173P2 cutinase cut2 YP_978406.1 2550110 D 410289 CDS YP_978407.1 121638183 4696589 2550908..2551150 1 NC_008769.1 hypothetical protein 2551150 4696589 BCG_2318 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978407.1 2550908 D 410289 CDS YP_978408.1 121638184 4696667 complement(2551191..2552114) 1 NC_008769.1 antibiotic-resistance protein 2552114 4696667 BCG_2319c Mycobacterium bovis BCG str. Pasteur 1173P2 antibiotic-resistance protein YP_978408.1 2551191 R 410289 CDS YP_978409.1 121638185 4698152 complement(2552111..2552320) 1 NC_008769.1 hypothetical protein 2552320 4698152 BCG_2320c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978409.1 2552111 R 410289 CDS YP_978410.1 121638186 4696728 2552904..2554193 1 NC_008769.1 Differs from Rv2305 by 1aa, D148G; hypothetical protein 2554193 4696728 BCG_2321 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978410.1 2552904 D 410289 CDS YP_978411.1 121638187 4696393 2554203..2554796 1 NC_008769.1 Differs from Rv2306A by 1aa, V47I; hypothetical protein 2554796 4696393 BCG_2322 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978411.1 2554203 D 410289 CDS YP_978412.1 121638188 4696506 2554583..2555017 1 NC_008769.1 hypothetical protein 2555017 4696506 BCG_2323 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978412.1 2554583 D 410289 CDS YP_978413.1 121638189 4697465 complement(2554946..2555791) 1 NC_008769.1 Differs from Mb2330c by 2aa, T25M, W235R; hypothetical protein 2555791 4697465 BCG_2324c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978413.1 2554946 R 410289 CDS YP_978414.1 121638190 4697620 complement(2556323..2556514) 1 NC_008769.1 hypothetical protein 2556514 4697620 BCG_2325c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978414.1 2556323 R 410289 CDS YP_978415.1 121638191 4696397 complement(2556599..2557030) 1 NC_008769.1 hypothetical protein 2557030 4696397 BCG_2326c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978415.1 2556599 R 410289 CDS YP_978416.1 121638192 4697135 complement(2557123..2557305) 1 NC_008769.1 hypothetical protein 2557305 4697135 BCG_2327c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978416.1 2557123 R 410289 CDS YP_978417.1 121638193 4699115 2557514..2558230 1 NC_008769.1 Differs from Rv2308 by 1aa, V43G; hypothetical protein 2558230 4699115 BCG_2328 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978417.1 2557514 D 410289 CDS YP_978418.1 121638194 4697286 complement(2558938..2559393) 1 NC_008769.1 integrase 2559393 4697286 BCG_2329c Mycobacterium bovis BCG str. Pasteur 1173P2 integrase YP_978418.1 2558938 R 410289 CDS YP_978419.1 121638195 4696346 2560140..2560427 1 NC_008769.1 Differs from Rv2309A by 1aa, K53E; hypothetical protein 2560427 4696346 BCG_2330 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978419.1 2560140 D 410289 CDS YP_978420.1 121638196 4697288 2560530..2560874 1 NC_008769.1 excisionase 2560874 4697288 BCG_2331 Mycobacterium bovis BCG str. Pasteur 1173P2 excisionase YP_978420.1 2560530 D 410289 CDS YP_978421.1 121638197 4695461 2560979..2561503 1 NC_008769.1 hypothetical protein 2561503 4695461 BCG_2332 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978421.1 2560979 D 410289 CDS YP_978422.1 121638198 4696900 2561581..2561850 1 NC_008769.1 hypothetical protein 2561850 4696900 BCG_2333 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978422.1 2561581 D 410289 CDS YP_978423.1 121638199 4695492 complement(2562147..2563001) 1 NC_008769.1 hypothetical protein 2563001 4695492 BCG_2334c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978423.1 2562147 R 410289 CDS YP_978424.1 121638200 4697993 complement(2563012..2564385) 1 NC_008769.1 hypothetical protein 2564385 4697993 BCG_2335c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978424.1 2563012 R 410289 CDS YP_978425.1 121638201 4695762 complement(2564382..2565899) 1 NC_008769.1 hypothetical protein 2565899 4695762 BCG_2336c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978425.1 2564382 R 410289 CDS YP_978426.1 121638202 4696361 2565933..2566805 1 NC_008769.1 Differs from Rv2316 by 1aa, L126V; sugar-transport integral membrane protein ABC transporter uspA 2566805 uspA 4696361 uspA Mycobacterium bovis BCG str. Pasteur 1173P2 sugar-transport integral membrane protein ABC transporter uspA YP_978426.1 2565933 D 410289 CDS YP_978427.1 121638203 4697746 2566792..2567616 1 NC_008769.1 sugar-transport integral membrane protein ABC transporter uspB 2567616 uspB 4697746 uspB Mycobacterium bovis BCG str. Pasteur 1173P2 sugar-transport integral membrane protein ABC transporter uspB YP_978427.1 2566792 D 410289 CDS YP_978428.1 121638204 4697747 2567613..2568935 1 NC_008769.1 Differs from Rv2318 by 1aa, V354L; periplasmic sugar-binding lipoprotein uspC 2568935 uspC 4697747 uspC Mycobacterium bovis BCG str. Pasteur 1173P2 periplasmic sugar-binding lipoprotein uspC YP_978428.1 2567613 D 410289 CDS YP_978429.1 121638205 4697748 complement(2568943..2569821) 1 NC_008769.1 Differs from Rv2319c and Mb2346c by 1aa, G105E; hypothetical protein 2569821 4697748 BCG_2340c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978429.1 2568943 R 410289 CDS YP_978430.1 121638206 4697357 complement(2569818..2571248) 1 NC_008769.1 cationic amino acid transport integral membrane protein rocE 2571248 rocE 4697357 rocE Mycobacterium bovis BCG str. Pasteur 1173P2 cationic amino acid transport integral membrane protein rocE YP_978430.1 2569818 R 410289 CDS YP_978431.1 121638207 4696322 complement(2571249..2571794) 1 NC_008769.1 ornithine aminotransferase (C-terminus part) rocD2 2571794 rocD2 4696322 rocD2 Mycobacterium bovis BCG str. Pasteur 1173P2 ornithine aminotransferase (C-terminus part) rocD2 YP_978431.1 2571249 R 410289 CDS YP_978432.1 121638208 4696321 complement(2571794..2572459) 1 NC_008769.1 ornithine aminotransferase (N-terminus part) rocD1 2572459 rocD1 4696321 rocD1 Mycobacterium bovis BCG str. Pasteur 1173P2 ornithine aminotransferase (N-terminus part) rocD1 YP_978432.1 2571794 R 410289 CDS YP_978433.1 121638209 4696320 complement(2572456..2573364) 1 NC_008769.1 Differs from Rv2323c by 1aa, T113A; hypothetical protein 2573364 4696320 BCG_2344c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978433.1 2572456 R 410289 CDS YP_978434.1 121638210 4696998 2573429..2573875 1 NC_008769.1 AsnC family transcriptional regulator 2573875 4696998 BCG_2345 Mycobacterium bovis BCG str. Pasteur 1173P2 AsnC family transcriptional regulator YP_978434.1 2573429 D 410289 CDS YP_978435.1 121638211 4698047 complement(2574104..2574952) 1 NC_008769.1 hypothetical protein 2574952 4698047 BCG_2346c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978435.1 2574104 R 410289 CDS YP_978436.1 121638212 4698014 complement(2574949..2577042) 1 NC_008769.1 transmembrane ABC transporter ATP-binding protein 2577042 4698014 BCG_2347c Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane ABC transporter ATP-binding protein YP_978436.1 2574949 R 410289 CDS YP_978437.1 121638213 4699326 2577083..2577574 1 NC_008769.1 hypothetical protein 2577574 4699326 BCG_2348 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978437.1 2577083 D 410289 CDS YP_978438.1 121638214 4699351 2577826..2578974 1 NC_008769.1 PE family protein 2578974 PE23 4699351 PE23 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_978438.1 2577826 D 410289 CDS YP_978439.1 121638215 4699379 complement(2579009..2580556) 1 NC_008769.1 nitrite extrusion protein 1 narK1 2580556 narK1 4699379 narK1 Mycobacterium bovis BCG str. Pasteur 1173P2 nitrite extrusion protein 1 narK1 YP_978439.1 2579009 R 410289 CDS YP_978440.1 121638216 4697118 complement(2580790..2581317) 1 NC_008769.1 Differs from Rv2330c and Mb2357c by 1aa, A97S; lipoprotein lppP 2581317 lppP 4697118 lppP Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppP YP_978440.1 2580790 R 410289 CDS YP_978441.1 121638217 4695921 2581392..2581778 1 NC_008769.1 hypothetical protein 2581778 4695921 BCG_2352 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978441.1 2581392 D 410289 CDS YP_978442.1 121638218 4699290 2581835..2582173 1 NC_008769.1 Differs from Rv2331A by 1aa, L46I; hypothetical protein 2582173 4699290 BCG_2353 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978442.1 2581835 D 410289 CDS YP_978443.1 121638219 4695430 2582203..2583849 1 NC_008769.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 2583849 mez 4695430 mez Mycobacterium bovis BCG str. Pasteur 1173P2 malate dehydrogenase YP_978443.1 2582203 D 410289 CDS YP_978444.1 121638220 4699107 complement(2583846..2585417) 1 NC_008769.1 In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, single base insertion (*-g) leads to a slightly longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (523 aa versus 537 aa). Also differs from Rv2333c by 2aa, Y69D, Q503H; integral membrane transport protein 2585417 4699107 BCG_2355c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane transport protein YP_978444.1 2583846 R 410289 CDS YP_978445.1 121638221 4696646 2585892..2586824 1 NC_008769.1 cysteine synthase A cysK1 2586824 cysK1 4696646 cysK1 Mycobacterium bovis BCG str. Pasteur 1173P2 cysteine synthase A cysK1 YP_978445.1 2585892 D 410289 CDS YP_978446.1 121638222 4695614 2586828..2587517 1 NC_008769.1 serine acetyltransferase cysE 2587517 4695614 BCG_2357 Mycobacterium bovis BCG str. Pasteur 1173P2 serine acetyltransferase cysE YP_978446.1 2586828 D 410289 CDS YP_978447.1 121638223 4695528 2587933..2588901 1 NC_008769.1 hypothetical protein 2588901 4695528 BCG_2358 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978447.1 2587933 D 410289 CDS YP_978448.1 121638224 4698525 complement(2588965..2590083) 1 NC_008769.1 Differs from Rv2337c by 1aa, V119G; hypothetical protein 2590083 4698525 BCG_2359c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978448.1 2588965 R 410289 CDS YP_978449.1 121638225 4696715 complement(2590203..2591159) 1 NC_008769.1 hypothetical protein 2591159 moeW 4696715 moeW Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978449.1 2590203 R 410289 CDS YP_978450.1 121638226 4697174 2591790..2594270 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base transition (g-a) splits mmpL9 into 2 parts, mmpL9a and mmpL9b; transmembrane transport protein mmpL9a 2594270 mmpL9a 4697174 mmpL9a Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane transport protein mmpL9a YP_978450.1 2591790 D 410289 CDS YP_978451.1 121638227 4696175 2594283..2594678 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) splits mmpL9 into 2 parts, mmpL9a and mmpL9b; transmembrane transport protein mmpL9b 2594678 mmpL9b 4696175 mmpL9b Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane transport protein mmpL9b YP_978451.1 2594283 D 410289 CDS YP_978452.1 121638228 4697489 complement(2594764..2596005) 1 NC_008769.1 Differs from Rv2340c and Mb2369c by 1aa, T222D; PE-PGRS family protein 2596005 PE_PGRS39 4697489 PE_PGRS39 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_978452.1 2594764 R 410289 CDS YP_978453.1 121638229 4697861 2596694..2597113 1 NC_008769.1 lipoprotein lppQ 2597113 lppQ 4697861 lppQ Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppQ YP_978453.1 2596694 D 410289 CDS YP_978454.1 121638230 4695922 2597369..2597626 1 NC_008769.1 hypothetical protein 2597626 4695922 BCG_2365 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978454.1 2597369 D 410289 CDS YP_978455.1 121638231 4698564 complement(2597630..2599549) 1 NC_008769.1 synthesizes RNA primers at the replication forks; DNA primase 2599549 dnaG 4698564 dnaG Mycobacterium bovis BCG str. Pasteur 1173P2 DNA primase YP_978455.1 2597630 R 410289 CDS YP_978456.1 121638232 4697835 complement(2599554..2600849) 1 NC_008769.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 2600849 dgt 4697835 dgt Mycobacterium bovis BCG str. Pasteur 1173P2 deoxyguanosinetriphosphate triphosphohydrolase-like protein YP_978456.1 2599554 R 410289 CDS YP_978457.1 121638233 4695556 2600918..2602900 1 NC_008769.1 hypothetical protein 2602900 4695556 BCG_2368 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978457.1 2600918 D 410289 CDS YP_978458.1 121638234 4696214 complement(2602985..2603167) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a large 8963 bp deletion (RD5) leads to the loss of the NH2 part of Rv2346c, and the 9 following CDSs up to Rv2356 including the 3 phospolipases C enzymes plcC, plcB and plcA, compared to the homolog in Mycobacterium tuberculosis H37Rv; ESAT-6 like protein 6 2603167 esxO 4696214 esxO Mycobacterium bovis BCG str. Pasteur 1173P2 ESAT-6 like protein 6 YP_978458.1 2602985 R 410289 CDS YP_978459.1 121638235 4698827 complement(2603151..2604557) 1 NC_008769.1 Compared to Mycobacterium bovis, there has been a 2579bp bp deletion at position equivalent to M. bovis 2604493-2607071, this has resulted in an in-frame fusion of the 5'-end of PPE40 with the 3'-end of PPE71 probably due to a homologous recombination event between codons 68 and 174 of PPE40 as the PPE40 and PPE71 genes have identical 5'-ends (first 535 bp). Differs from Mb2376c (PPE71) by extra 11aa, insertion of A at position 68 due to 3bp insertion (present in PPE40) and STNVGSGNIG at position 307 due to 30 bp insertion. M. bovis BCG Pasteur thus has three copies of tandem repeat STNVGSGNIG compared to two in Mb2376c. The 3'-end of PPE71 of M. bovis BCG Pasteur has also been truncated as a result of the same deletion described in In Mycobacterium bovis, 8963 bp deletion (RD5); PPE family protein 2604557 PPE71 4698827 PPE71 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_978459.1 2603151 R 410289 CDS YP_978460.1 121638236 4696416 complement(2604695..2606086) 1 NC_008769.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase 2606086 glyS 4696416 glyS Mycobacterium bovis BCG str. Pasteur 1173P2 glycyl-tRNA synthetase YP_978460.1 2604695 R 410289 CDS YP_978461.1 121638237 4697848 2606268..2606675 1 NC_008769.1 ArsR family transcriptional regulator 2606675 4697848 BCG_2372 Mycobacterium bovis BCG str. Pasteur 1173P2 ArsR family transcriptional regulator YP_978461.1 2606268 D 410289 CDS YP_978462.1 121638238 4695438 2606672..2607064 1 NC_008769.1 Differs from Rv2359 by 1aa, R64H; ferric uptake regulation protein furB 2607064 furB 4695438 furB Mycobacterium bovis BCG str. Pasteur 1173P2 ferric uptake regulation protein furB YP_978462.1 2606672 D 410289 CDS YP_978463.1 121638239 4695505 complement(2607172..2607600) 1 NC_008769.1 Differs from Rv2360c by 1aa, T66A; hypothetical protein 2607600 4695505 BCG_2374c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978463.1 2607172 R 410289 CDS YP_978464.1 121638240 4697692 complement(2607600..2608490) 1 NC_008769.1 catalyzes the formation of UDP pyrophosphate from isopentenyl pyrophosphate; UDP pyrophosphate synthase 2608490 4697692 BCG_2375c Mycobacterium bovis BCG str. Pasteur 1173P2 UDP pyrophosphate synthase YP_978464.1 2607600 R 410289 CDS YP_978465.1 121638241 4698079 complement(2608483..2609280) 1 NC_008769.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 2609280 recO 4698079 recO Mycobacterium bovis BCG str. Pasteur 1173P2 DNA repair protein RecO YP_978465.1 2608483 R 410289 CDS YP_978466.1 121638242 4695691 2609342..2610796 1 NC_008769.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 2610796 amiA2 4695691 amiA2 Mycobacterium bovis BCG str. Pasteur 1173P2 amidase YP_978466.1 2609342 D 410289 CDS YP_978467.1 121638243 4696631 complement(2610793..2611695) 1 NC_008769.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 2611695 era 4696631 era Mycobacterium bovis BCG str. Pasteur 1173P2 GTP-binding protein Era YP_978467.1 2610793 R 410289 CDS YP_978468.1 121638244 4697857 complement(2611769..2612110) 1 NC_008769.1 hypothetical protein 2612110 4697857 BCG_2379c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978468.1 2611769 R 410289 CDS YP_978469.1 121638245 4696483 complement(2612082..2613389) 1 NC_008769.1 hypothetical protein 2613389 4696483 BCG_2380c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978469.1 2612082 R 410289 CDS YP_978470.1 121638246 4698110 complement(2613386..2613934) 1 NC_008769.1 metalloprotease 2613934 4698110 BCG_2381c Mycobacterium bovis BCG str. Pasteur 1173P2 metalloprotease YP_978470.1 2613386 R 410289 CDS YP_978471.1 121638247 4695580 complement(2613938..2614996) 1 NC_008769.1 phoH-like protein phoH1 2614996 phoH1 4695580 phoH1 Mycobacterium bovis BCG str. Pasteur 1173P2 phoH-like protein phoH1 YP_978471.1 2613938 R 410289 CDS YP_978472.1 121638248 4697585 complement(2614968..2615270) 1 NC_008769.1 hypothetical protein 2615270 4697585 BCG_2383c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978472.1 2614968 R 410289 CDS YP_978473.1 121638249 4697255 complement(2615267..2616580) 1 NC_008769.1 hypothetical protein 2616580 4697255 BCG_2384c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978473.1 2615267 R 410289 CDS YP_978474.1 121638250 4695454 2616775..2616960 1 NC_008769.1 PE-PGRS family protein 2616960 PE_PGRS40 4695454 PE_PGRS40 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_978474.1 2616775 D 410289 CDS YP_978475.1 121638251 4697096 complement(2617059..2617847) 1 NC_008769.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 2617847 4697096 BCG_2386c Mycobacterium bovis BCG str. Pasteur 1173P2 16S ribosomal RNA methyltransferase RsmE YP_978475.1 2617059 R 410289 CDS YP_978476.1 121638252 4697691 complement(2617861..2619009) 1 NC_008769.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 2619009 dnaJ2 4697691 dnaJ2 Mycobacterium bovis BCG str. Pasteur 1173P2 chaperone protein DnaJ YP_978476.1 2617861 R 410289 CDS YP_978477.1 121638253 4697210 complement(2619084..2620115) 1 NC_008769.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 2620115 hrcA 4697210 hrcA Mycobacterium bovis BCG str. Pasteur 1173P2 heat-inducible transcription repressor YP_978477.1 2619084 R 410289 CDS YP_978478.1 121638254 4697335 2620287..2620604 1 NC_008769.1 hypothetical protein 2620604 4697335 BCG_2389 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978478.1 2620287 D 410289 CDS YP_978479.1 121638255 4697997 complement(2620631..2621137) 1 NC_008769.1 low molecular weight antigen cfp2 2621137 cfp2 4697997 cfp2 Mycobacterium bovis BCG str. Pasteur 1173P2 low molecular weight antigen cfp2 YP_978479.1 2620631 R 410289 CDS YP_978480.1 121638256 4698223 complement(2621237..2621452) 1 NC_008769.1 Differs from Rv2377c by 1aa, A69V; protein mbtH 2621452 mbtH 4698223 mbtH Mycobacterium bovis BCG str. Pasteur 1173P2 protein mbtH YP_978480.1 2621237 R 410289 CDS YP_978481.1 121638257 4695347 complement(2621430..2622725) 1 NC_008769.1 lysine-N-oxygenase mbtG 2622725 mbtG 4695347 mbtG Mycobacterium bovis BCG str. Pasteur 1173P2 lysine-N-oxygenase mbtG YP_978481.1 2621430 R 410289 CDS YP_978482.1 121638258 4695792 complement(2622722..2627107) 1 NC_008769.1 Differs from Rv2379c by 1aa, D589E; peptide synthetase mbtF 2627107 mbtF 4695792 mbtF Mycobacterium bovis BCG str. Pasteur 1173P2 peptide synthetase mbtF YP_978482.1 2622722 R 410289 CDS YP_978483.1 121638259 4695791 complement(2627089..2632137) 1 NC_008769.1 peptide synthetase mbtE 2632137 mbtE 4695791 mbtE Mycobacterium bovis BCG str. Pasteur 1173P2 peptide synthetase mbtE YP_978483.1 2627089 R 410289 CDS YP_978484.1 121638260 4695790 complement(2632277..2635291) 1 NC_008769.1 polyketide synthase 2635291 mbtD 4695790 mbtD Mycobacterium bovis BCG str. Pasteur 1173P2 polyketide synthase YP_978484.1 2632277 R 410289 CDS YP_978485.1 121638261 4695789 complement(2635291..2636625) 1 NC_008769.1 polyketide synthase 2636625 mbtC 4695789 mbtC Mycobacterium bovis BCG str. Pasteur 1173P2 polyketide synthase YP_978485.1 2635291 R 410289 CDS YP_978486.1 121638262 4695788 complement(2636615..2640859) 1 NC_008769.1 Differs from Rv2383c by 2aa, Q264R, P1253T, and from Mb2404c by 1aa, P1253T; phenyloxazoline synthase mbtB 2640859 mbtB 4695788 mbtB Mycobacterium bovis BCG str. Pasteur 1173P2 phenyloxazoline synthase mbtB YP_978486.1 2636615 R 410289 CDS YP_978487.1 121638263 4698665 2640958..2642655 1 NC_008769.1 bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase 2642655 mbtA 4698665 mbtA Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase YP_978487.1 2640958 D 410289 CDS YP_978488.1 121638264 4698664 2642751..2643671 1 NC_008769.1 acetyl hydrolase mbtJ 2643671 mbtJ 4698664 mbtJ Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl hydrolase mbtJ YP_978488.1 2642751 D 410289 CDS YP_978489.1 121638265 4695349 complement(2643675..2645027) 1 NC_008769.1 catalyzes conversion of chorismate to salicylate, in mycobactin siderophore construction; requires Mg(2+) for function; salicylate synthase MbtI 2645027 mbtI 4695349 mbtI Mycobacterium bovis BCG str. Pasteur 1173P2 salicylate synthase MbtI YP_978489.1 2643675 R 410289 CDS YP_978490.1 121638266 4695348 2645787..2647040 1 NC_008769.1 hypothetical protein 2647040 4695348 BCG_2401 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978490.1 2645787 D 410289 CDS YP_978491.1 121638267 4696556 complement(2647037..2648164) 1 NC_008769.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 2648164 hemN 4696556 hemN Mycobacterium bovis BCG str. Pasteur 1173P2 coproporphyrinogen III oxidase YP_978491.1 2647037 R 410289 CDS YP_978492.1 121638268 4698930 complement(2648270..2648734) 1 NC_008769.1 resuscitation-promoting factor rpfD 2648734 rpfD 4698930 rpfD Mycobacterium bovis BCG str. Pasteur 1173P2 resuscitation-promoting factor rpfD YP_978492.1 2648270 R 410289 CDS YP_978493.1 121638269 4699110 complement(2648731..2649288) 1 NC_008769.1 Differs from Mb2411c by 1aa, I33T; hypothetical protein 2649288 4699110 BCG_2404c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978493.1 2648731 R 410289 CDS YP_978494.1 121638270 4699039 2649701..2651392 1 NC_008769.1 ferredoxin-dependent nitrite reductase NirA 2651392 nirA 4699039 nirA Mycobacterium bovis BCG str. Pasteur 1173P2 ferredoxin-dependent nitrite reductase NirA YP_978494.1 2649701 D 410289 CDS YP_978495.1 121638271 4699205 2651389..2652153 1 NC_008769.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 2652153 cysH 4699205 cysH Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoadenosine phosphosulfate reductase YP_978495.1 2651389 D 410289 CDS YP_978496.1 121638272 4696089 2652150..2653049 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, duplication of 54 bp segment after codon 3 leads to additional 18 aa and two tandem copies of motif PATMQSAAMLRSGAIEAP, compared to its ortholog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis AF2122/97; hypothetical protein 2653049 4696089 BCG_2407 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978496.1 2652150 D 410289 CDS YP_978497.1 121638273 4696147 2653086..2655017 1 NC_008769.1 Differs from Rv2394 by 1aa Q396R; gamma-glutamyltranspeptidase precursor ggtB 2655017 ggtB 4696147 ggtB Mycobacterium bovis BCG str. Pasteur 1173P2 gamma-glutamyltranspeptidase precursor ggtB YP_978497.1 2653086 D 410289 CDS YP_978498.1 121638274 4698648 2655148..2655588 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis BCG Pasteur, as in Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits Rv2395 into 2 parts. The frameshift occurs after the 44th codon; integral membrane protein 2655588 4698648 BCG_2409 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_978498.1 2655148 D 410289 CDS YP_978499.1 121638275 4696229 2655602..2657152 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits Rv2395 into 2 parts. BCG_2410 also differs from Rv2395 by 1aa, P396S; integral membrane protein 2657152 4696229 BCG_2410 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_978499.1 2655602 D 410289 CDS YP_978500.1 121638276 4698075 2657876..2658958 1 NC_008769.1 Identical to Mb2418 of Mycobacterium bovis, including 3 bp deletion (gcc-*) that leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (360 aa versus 361 aa) due to deletion of A95. Also differs from Rv2396 by 2aa, N26S, S324N; PE-PGRS family protein 2658958 PE_PGRS41 4698075 PE_PGRS41 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_978500.1 2657876 D 410289 CDS YP_978501.1 121638277 4697097 complement(2658983..2660038) 1 NC_008769.1 sulfate-transport ATP-binding protein ABC transporter cysA1 2660038 cysA1 4697097 cysA1 Mycobacterium bovis BCG str. Pasteur 1173P2 sulfate-transport ATP-binding protein ABC transporter cysA1 YP_978501.1 2658983 R 410289 CDS YP_978502.1 121638278 4698202 complement(2660055..2660873) 1 NC_008769.1 Differs from Rv2398c by 1aa, A141G, and from Mb2420c by 1aa, R264H; sulfate-transport integral membrane protein ABC transporter cysW 2660873 cysW 4698202 cysW Mycobacterium bovis BCG str. Pasteur 1173P2 sulfate-transport integral membrane protein ABC transporter cysW YP_978502.1 2660055 R 410289 CDS YP_978503.1 121638279 4699054 complement(2660870..2661721) 1 NC_008769.1 sulfate-transport integral membrane protein ABC transporter cysT 2661721 cysT 4699054 cysT Mycobacterium bovis BCG str. Pasteur 1173P2 sulfate-transport integral membrane protein ABC transporter cysT YP_978503.1 2660870 R 410289 CDS YP_978504.1 121638280 4696907 complement(2661718..2662788) 1 NC_008769.1 sulfate-binding lipoprotein subI 2662788 subI 4696907 subI Mycobacterium bovis BCG str. Pasteur 1173P2 sulfate-binding lipoprotein subI YP_978504.1 2661718 R 410289 CDS YP_978505.1 121638281 4696757 2662802..2663131 1 NC_008769.1 hypothetical protein 2663131 4696757 BCG_2416 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978505.1 2662802 D 410289 CDS YP_978506.1 121638282 4698121 complement(2663116..2663319) 1 NC_008769.1 hypothetical protein 2663319 4698121 BCG_2417c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978506.1 2663116 R 410289 CDS YP_978507.1 121638283 4697387 2663603..2665531 1 NC_008769.1 hypothetical protein 2665531 4697387 BCG_2418 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978507.1 2663603 D 410289 CDS YP_978508.1 121638284 4697245 complement(2665609..2666364) 1 NC_008769.1 Differs from Rv2403c by 1aa, L127V; lipoprotein lppR 2666364 lppR 4697245 lppR Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppR YP_978508.1 2665609 R 410289 CDS YP_978509.1 121638285 4695923 complement(2666361..2668322) 1 NC_008769.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 2668322 lepA 4695923 lepA Mycobacterium bovis BCG str. Pasteur 1173P2 GTP-binding protein LepA YP_978509.1 2666361 R 410289 CDS YP_978510.1 121638286 4695956 2668343..2668912 1 NC_008769.1 hypothetical protein 2668912 4695956 BCG_2421 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978510.1 2668343 D 410289 CDS YP_978511.1 121638287 4698587 complement(2669083..2669511) 1 NC_008769.1 hypothetical protein 2669511 4698587 BCG_2422c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978511.1 2669083 R 410289 CDS YP_978512.1 121638288 4698347 2669771..2670613 1 NC_008769.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2670613 4698347 BCG_2423 Mycobacterium bovis BCG str. Pasteur 1173P2 ribonuclease Z YP_978512.1 2669771 D 410289 CDS YP_978513.1 121638289 4698138 2671206..2671925 1 NC_008769.1 PE family-like protein 2671925 PE24 4698138 PE24 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family-like protein YP_978513.1 2671206 D 410289 CDS YP_978514.1 121638290 4699380 complement(2671683..2672522) 1 NC_008769.1 hypothetical protein 2672522 4699380 BCG_2425c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978514.1 2671683 R 410289 CDS YP_978515.1 121638291 4699330 complement(2672522..2673499) 1 NC_008769.1 hypothetical protein 2673499 4699330 BCG_2426c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978515.1 2672522 R 410289 CDS YP_978516.1 121638292 4698107 complement(2673499..2675154) 1 NC_008769.1 hypothetical protein 2675154 4698107 BCG_2427c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978516.1 2673499 R 410289 CDS YP_978517.1 121638293 4696622 2675264..2675524 1 NC_008769.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 2675524 rpsT 4696622 rpsT Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S20 YP_978517.1 2675264 D 410289 CDS YP_978518.1 121638294 4697804 complement(2675540..2676490) 1 NC_008769.1 hypothetical protein 2676490 4697804 BCG_2429c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978518.1 2675540 R 410289 CDS YP_978519.1 121638295 4698900 complement(2676521..2678065) 1 NC_008769.1 In Mycobacterium bovis, a single base insertion (*-t) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv and in Mycobacterium bovis BCG Pasteur (523 aa versus 514 aa); hypothetical protein 2678065 4698900 BCG_2430c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978519.1 2676521 R 410289 CDS YP_978520.1 121638296 4698350 complement(2678080..2678973) 1 NC_008769.1 Differs from Rv2415c by 1aa, L291R; hypothetical protein 2678973 4698350 BCG_2431c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978520.1 2678080 R 410289 CDS YP_978521.1 121638297 4695660 complement(2679313..2680539) 1 NC_008769.1 Differs from Mb2439c by 1aa, T76A; hypothetical protein 2680539 4695660 BCG_2432c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978521.1 2679313 R 410289 CDS YP_978522.1 121638298 4695868 complement(2680661..2681503) 1 NC_008769.1 hypothetical protein 2681503 4695868 BCG_2433c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978522.1 2680661 R 410289 CDS YP_978523.1 121638299 4698531 complement(2681584..2682327) 1 NC_008769.1 hypothetical protein 2682327 4698531 BCG_2434c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978523.1 2681584 R 410289 CDS YP_978524.1 121638300 4697021 complement(2682317..2682988) 1 NC_008769.1 Differs from Mb2442c by 1aa, A165V; phosphoglycerate mutase 2682988 4697021 BCG_2435c Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoglycerate mutase YP_978524.1 2682317 R 410289 CDS YP_978525.1 121638301 4697110 complement(2682985..2683368) 1 NC_008769.1 Differs from Rv2420c and Mb2443c by insertion of 1aa, Pro, at position 126 due to 3bp insertion (gcg) at position equivalent to Mycobacterium bovis 2685985-2685986; hypothetical protein 2683368 4697110 BCG_2436c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978525.1 2682985 R 410289 CDS YP_978526.1 121638302 4696761 complement(2683365..2684000) 1 NC_008769.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 2684000 nadD 4696761 nadD Mycobacterium bovis BCG str. Pasteur 1173P2 nicotinic acid mononucleotide adenylyltransferase YP_978526.1 2683365 R 410289 CDS YP_978527.1 121638303 4696614 2684275..2684547 1 NC_008769.1 hypothetical protein 2684547 4696614 BCG_2438 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978527.1 2684275 D 410289 CDS YP_978528.1 121638304 4699293 2684789..2685835 1 NC_008769.1 hypothetical protein 2685835 4699293 BCG_2439 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978528.1 2684789 D 410289 CDS YP_978529.1 121638305 4698469 complement(2685968..2686660) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 2 bp deletion (gt-*) splits Rv2424c into 2 parts. Differs from Rv2424c by 3aa, I172T, A173T and Y192H; transposase 2686660 4698469 BCG_2440c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_978529.1 2685968 R 410289 CDS YP_978530.1 121638306 4696381 complement(2686674..2686967) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 2 bp deletion (gt-*) splits Rv2424c into 2 parts; transposase 2686967 4696381 BCG_2441c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_978530.1 2686674 R 410289 CDS YP_978531.1 121638307 4696265 complement(2687056..2688498) 1 NC_008769.1 hypothetical protein 2688498 4696265 BCG_2442c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978531.1 2687056 R 410289 CDS YP_978532.1 121638308 4698415 complement(2688498..2689373) 1 NC_008769.1 Differs from Rv2426c by 1aa, L113F; hypothetical protein 2689373 4698415 BCG_2443c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978532.1 2688498 R 410289 CDS YP_978533.1 121638309 4696716 complement(2689400..2690647) 1 NC_008769.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 2690647 proA 4696716 proA Mycobacterium bovis BCG str. Pasteur 1173P2 gamma-glutamyl phosphate reductase YP_978533.1 2689400 R 410289 CDS YP_978534.1 121638310 4695523 2691363..2691950 1 NC_008769.1 alkyl hydroperoxide reductase 2691950 ahpC 4695523 ahpC Mycobacterium bovis BCG str. Pasteur 1173P2 alkyl hydroperoxide reductase YP_978534.1 2691363 D 410289 CDS YP_978535.1 121638311 4695782 2691976..2692509 1 NC_008769.1 alkyl hydroperoxide reductase 2692509 ahpD 4695782 ahpD Mycobacterium bovis BCG str. Pasteur 1173P2 alkyl hydroperoxide reductase YP_978535.1 2691976 D 410289 CDS YP_978536.1 121638312 4697590 complement(2692506..2693090) 1 NC_008769.1 PPE family protein 2693090 PPE41 4697590 PPE41 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_978536.1 2692506 R 410289 CDS YP_978537.1 121638313 4697819 complement(2693137..2693436) 1 NC_008769.1 PE family protein 2693436 PE25 4697819 PE25 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_978537.1 2693137 R 410289 CDS YP_978538.1 121638314 4697125 complement(2693607..2694017) 1 NC_008769.1 hypothetical protein 2694017 4697125 BCG_2451c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978538.1 2693607 R 410289 CDS YP_978539.1 121638315 4695895 complement(2694014..2694304) 1 NC_008769.1 hypothetical protein 2694304 4695895 BCG_2452c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978539.1 2694014 R 410289 CDS YP_978540.1 121638316 4697122 complement(2694285..2695730) 1 NC_008769.1 hypothetical protein 2695730 4697122 BCG_2453c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978540.1 2694285 R 410289 CDS YP_978541.1 121638317 4695527 complement(2695727..2697919) 1 NC_008769.1 cyclase 2697919 4695527 BCG_2454c Mycobacterium bovis BCG str. Pasteur 1173P2 cyclase YP_978541.1 2695727 R 410289 CDS YP_978542.1 121638318 4698465 2698400..2699314 1 NC_008769.1 Differs from Rv2436 by 2aa, V274A, A282V; ribokinase rbsK 2699314 rbsK 4698465 rbsK Mycobacterium bovis BCG str. Pasteur 1173P2 ribokinase rbsK YP_978542.1 2698400 D 410289 CDS YP_978543.1 121638319 4697308 2699546..2699965 1 NC_008769.1 hypothetical protein 2699965 4697308 BCG_2456 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978543.1 2699546 D 410289 CDS YP_978544.1 121638320 4695812 complement(2699962..2702001) 1 NC_008769.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 2702001 nadE 4695812 nadE Mycobacterium bovis BCG str. Pasteur 1173P2 NAD synthetase YP_978544.1 2699962 R 410289 CDS YP_978545.1 121638321 4696615 2701879..2702157 1 NC_008769.1 hypothetical protein 2702157 4696615 BCG_2458 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978545.1 2701879 D 410289 CDS YP_978546.1 121638322 4695693 complement(2702287..2703417) 1 NC_008769.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 2703417 proB 4695693 proB Mycobacterium bovis BCG str. Pasteur 1173P2 gamma-glutamyl kinase YP_978546.1 2702287 R 410289 CDS YP_978547.1 121638323 4697856 complement(2703417..2704856) 1 NC_008769.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 2704856 obgE 4697856 obgE Mycobacterium bovis BCG str. Pasteur 1173P2 GTPase ObgE YP_978547.1 2703417 R 410289 CDS YP_978548.1 121638324 4696324 complement(2704942..2705202) 1 NC_008769.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 2705202 rpmA 4696324 rpmA Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L27 YP_978548.1 2704942 R 410289 CDS YP_978549.1 121638325 4697628 complement(2705217..2705531) 1 NC_008769.1 50S ribosomal protein L21 2705531 rplU 4697628 rplU Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L21 YP_978549.1 2705217 R 410289 CDS YP_978550.1 121638326 4695881 2705879..2707354 1 NC_008769.1 C4-dicarboxylate-transport transmembrane protein dctA 2707354 dctA 4695881 dctA Mycobacterium bovis BCG str. Pasteur 1173P2 C4-dicarboxylate-transport transmembrane protein dctA YP_978550.1 2705879 D 410289 CDS YP_978551.1 121638327 4696805 complement(2707293..2710154) 1 NC_008769.1 ribonuclease E rne 2710154 rne 4696805 rne Mycobacterium bovis BCG str. Pasteur 1173P2 ribonuclease E rne YP_978551.1 2707293 R 410289 CDS YP_978552.1 121638328 4697607 complement(2710484..2710894) 1 NC_008769.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 2710894 ndk 4697607 ndk Mycobacterium bovis BCG str. Pasteur 1173P2 nucleoside diphosphate kinase YP_978552.1 2710484 R 410289 CDS YP_978553.1 121638329 4696139 complement(2710937..2711308) 1 NC_008769.1 integral membrane protein 2711308 4696139 BCG_2466c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_978553.1 2710937 R 410289 CDS YP_978554.1 121638330 4698131 complement(2711305..2712768) 1 NC_008769.1 folylpolyglutamate synthase folC 2712768 folC 4698131 folC Mycobacterium bovis BCG str. Pasteur 1173P2 folylpolyglutamate synthase folC YP_978554.1 2711305 R 410289 CDS YP_978555.1 121638331 4697987 complement(2712765..2715395) 1 NC_008769.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 2715395 valS 4697987 valS Mycobacterium bovis BCG str. Pasteur 1173P2 valyl-tRNA synthetase YP_978555.1 2712765 R 410289 CDS YP_978556.1 121638332 4697231 complement(2715483..2716742) 1 NC_008769.1 Differs from Rv2449c and Mb2476c by 1aa, C273R; hypothetical protein 2716742 4697231 BCG_2469c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978556.1 2715483 R 410289 CDS YP_978557.1 121638333 4697302 complement(2716832..2717350) 1 NC_008769.1 Differs from Rv2450c by 1aa, Q126R; resuscitation-promoting factor rpfE 2717350 rpfE 4697302 rpfE Mycobacterium bovis BCG str. Pasteur 1173P2 resuscitation-promoting factor rpfE YP_978557.1 2716832 R 410289 CDS YP_978558.1 121638334 4699111 2717432..2717830 1 NC_008769.1 Differs from Rv2451 by 1aa, D63N; hypothetical protein 2717830 4699111 BCG_2471 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978558.1 2717432 D 410289 CDS YP_978559.1 121638335 4696095 complement(2718018..2718164) 1 NC_008769.1 hypothetical protein 2718164 4696095 BCG_2472c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978559.1 2718018 R 410289 CDS YP_978560.1 121638336 4695592 complement(2718188..2718793) 1 NC_008769.1 MobA; links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide; involved in molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein A 2718793 mobA 4695592 mobA Mycobacterium bovis BCG str. Pasteur 1173P2 molybdopterin-guanine dinucleotide biosynthesis protein A YP_978560.1 2718188 R 410289 CDS YP_978561.1 121638337 4695566 complement(2718795..2719916) 1 NC_008769.1 catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin; 2-oxoglutarate ferredoxin oxidoreductase subunit beta 2719916 4695566 BCG_2474c Mycobacterium bovis BCG str. Pasteur 1173P2 2-oxoglutarate ferredoxin oxidoreductase subunit beta YP_978561.1 2718795 R 410289 CDS YP_978562.1 121638338 4695445 complement(2719913..2721874) 1 NC_008769.1 oxidoreductase subunit alpha 2721874 4695445 BCG_2475c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase subunit alpha YP_978562.1 2719913 R 410289 CDS YP_978563.1 121638339 4696196 complement(2722106..2723362) 1 NC_008769.1 integral membrane transport protein 2723362 4696196 BCG_2476c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane transport protein YP_978563.1 2722106 R 410289 CDS YP_978564.1 121638340 4695732 complement(2723378..2724658) 1 NC_008769.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 2724658 clpX 4695732 clpX Mycobacterium bovis BCG str. Pasteur 1173P2 ATP-dependent protease ATP-binding subunit ClpX YP_978564.1 2723378 R 410289 CDS YP_978565.1 121638341 4698060 2724949..2725857 1 NC_008769.1 converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines; homocysteine methyltransferase 2725857 mmuM 4698060 mmuM Mycobacterium bovis BCG str. Pasteur 1173P2 homocysteine methyltransferase YP_978565.1 2724949 D 410289 CDS YP_978566.1 121638342 4698504 2726024..2727550 1 NC_008769.1 Differs from Mb2486 by 1aa, M55I; integral membrane transport protein 2727550 4698504 BCG_2479 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane transport protein YP_978566.1 2726024 D 410289 CDS YP_978567.1 121638343 4696484 complement(2727701..2728345) 1 NC_008769.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 2728345 clpP2 4696484 clpP2 Mycobacterium bovis BCG str. Pasteur 1173P2 ATP-dependent Clp protease proteolytic subunit YP_978567.1 2727701 R 410289 CDS YP_978568.1 121638344 4698479 complement(2728342..2728944) 1 NC_008769.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 2728944 clpP 4698479 clpP Mycobacterium bovis BCG str. Pasteur 1173P2 ATP-dependent Clp protease proteolytic subunit YP_978568.1 2728342 R 410289 CDS YP_978569.1 121638345 4698437 complement(2729061..2730461) 1 NC_008769.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 2730461 tig 4698437 tig Mycobacterium bovis BCG str. Pasteur 1173P2 trigger factor YP_978569.1 2729061 R 410289 CDS YP_978570.1 121638346 4696330 2730825..2732009 1 NC_008769.1 esterase/lipase lipP 2732009 lipP 4696330 lipP Mycobacterium bovis BCG str. Pasteur 1173P2 esterase/lipase lipP YP_978570.1 2730825 D 410289 CDS YP_978571.1 121638347 4696902 complement(2732029..2732835) 1 NC_008769.1 DNA glycosylase 2732835 4696902 BCG_2484c Mycobacterium bovis BCG str. Pasteur 1173P2 DNA glycosylase YP_978571.1 2732029 R 410289 CDS YP_978572.1 121638348 4696217 complement(2732841..2733329) 1 NC_008769.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 2733329 rpiB 4696217 rpiB Mycobacterium bovis BCG str. Pasteur 1173P2 ribose-5-phosphate isomerase B YP_978572.1 2732841 R 410289 CDS YP_978573.1 121638349 4699113 complement(2733431..2734054) 1 NC_008769.1 hypothetical protein 2734054 4699113 BCG_2486c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978573.1 2733431 R 410289 CDS YP_978574.1 121638350 4696640 2734156..2736741 1 NC_008769.1 Differs from Rv2467 and Mb2494 by 1aa, M18I; aminopeptidase N pepN 2736741 pepN 4696640 pepN Mycobacterium bovis BCG str. Pasteur 1173P2 aminopeptidase N pepN YP_978574.1 2734156 D 410289 CDS YP_978575.1 121638351 4696293 complement(2736814..2737317) 1 NC_008769.1 hypothetical protein 2737317 4696293 BCG_2488c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978575.1 2736814 R 410289 CDS YP_978576.1 121638352 4696486 complement(2737537..2738205) 1 NC_008769.1 Differs from Rv2469c by 2aa, G28S, S99A; hypothetical protein 2738205 4696486 BCG_2489c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978576.1 2737537 R 410289 CDS YP_978577.1 121638353 4696625 2738348..2738734 1 NC_008769.1 globin (oxygen-binding protein) glbO 2738734 glbO 4696625 glbO Mycobacterium bovis BCG str. Pasteur 1173P2 globin (oxygen-binding protein) glbO YP_978577.1 2738348 D 410289 CDS YP_978578.1 121638354 4697397 2738734..2740374 1 NC_008769.1 Differs from Rv2471 by 1aa, S206W; alpha-glucosidase aglA 2740374 aglA 4697397 aglA Mycobacterium bovis BCG str. Pasteur 1173P2 alpha-glucosidase aglA YP_978578.1 2738734 D 410289 CDS YP_978579.1 121638355 4696510 2740442..2740735 1 NC_008769.1 hypothetical protein 2740735 4696510 BCG_2492 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978579.1 2740442 D 410289 CDS YP_978580.1 121638356 4696411 2740738..2741454 1 NC_008769.1 hypothetical protein 2741454 4696411 BCG_2493 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978580.1 2740738 D 410289 CDS YP_978581.1 121638357 4696469 complement(2741486..2742139) 1 NC_008769.1 Differs from Mb2501c by 1aa, A30V; hypothetical protein 2742139 4696469 BCG_2494c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978581.1 2741486 R 410289 CDS YP_978582.1 121638358 4696213 complement(2742145..2742561) 1 NC_008769.1 hypothetical protein 2742561 4696213 BCG_2495c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978582.1 2742145 R 410289 CDS YP_978583.1 121638359 4696231 complement(2742558..2747429) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 3 bp deletion (cgg-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1623 aa versus 1624 aa). Differs from Rv2476c by 2aa, loss of A501 due to 3 bp deletion and G1042S; NAD-dependent glutamate dehydrogenase gdh 2747429 gdh 4696231 gdh Mycobacterium bovis BCG str. Pasteur 1173P2 NAD-dependent glutamate dehydrogenase gdh YP_978583.1 2742558 R 410289 CDS YP_978584.1 121638360 4698646 complement(2747533..2749209) 1 NC_008769.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 2749209 4698646 BCG_2497c Mycobacterium bovis BCG str. Pasteur 1173P2 ABC transporter ATP-binding protein YP_978584.1 2747533 R 410289 CDS YP_978585.1 121638361 4696155 complement(2749290..2749775) 1 NC_008769.1 hypothetical protein 2749775 4696155 BCG_2498 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978585.1 2749290 R 410289 CDS YP_978586.1 121638362 4695703 complement(2750384..2750707) 1 NC_008769.1 hypothetical protein 2750707 4695703 BCG_2499c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978586.1 2750384 R 410289 CDS YP_978587.1 121638363 4695710 complement(2750723..2753092) 1 NC_008769.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 2753092 plsB2 4695710 plsB2 Mycobacterium bovis BCG str. Pasteur 1173P2 glycerol-3-phosphate acyltransferase YP_978587.1 2750723 R 410289 CDS YP_978588.1 121638364 4695944 complement(2753089..2754831) 1 NC_008769.1 Differs from Rv2483c by 1aa, G189C; transmembrane phospholipid biosynthesis bifunctionnal l-3-phosphoserine phosphatase/1-acyl-SN-glycerol-3-phosphate acyltransferase 2754831 plsC 4695944 plsC Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane phospholipid biosynthesis bifunctionnal l-3-phosphoserine phosphatase/1-acyl-SN-glycerol-3-phosphate acyltransferase YP_978588.1 2753089 R 410289 CDS YP_978589.1 121638365 4695945 complement(2754828..2756303) 1 NC_008769.1 Differs from Rv2484c by 1aa, D466G; hypothetical protein 2756303 4695945 BCG_2502c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978589.1 2754828 R 410289 CDS YP_978590.1 121638366 4695390 complement(2756532..2757797) 1 NC_008769.1 carboxylesterase lipQ 2757797 lipQ 4695390 lipQ Mycobacterium bovis BCG str. Pasteur 1173P2 carboxylesterase lipQ YP_978590.1 2756532 R 410289 CDS YP_978591.1 121638367 4697860 2758159..2758929 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2758929 echA14 4697860 echA14 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_978591.1 2758159 D 410289 CDS YP_978592.1 121638368 4695727 complement(2759609..2761192) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts, the first due to a single base insertion (*-c) and the second due to a single base deletion (g-*) splits PE_PGRS42 into 3 parts, PE_PGRS42a and PE_PGRS42b and PE_PGRS42d while in Mycobacterium bovis BCG Pasteur, PE_PGRS42a and PE_GRRS42b are fused; PE-PGRS family protein 2761192 PE_PGRS42ab 4695727 PE_PGRS42ab Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_978592.1 2759609 R 410289 CDS YP_978593.1 121638369 4695726 complement(2761274..2764687) 1 NC_008769.1 Differs from Rv2488c and Mb2515c by 1aa E535D; LuxR family transcriptional regulator 2764687 4695726 BCG_2507c Mycobacterium bovis BCG str. Pasteur 1173P2 LuxR family transcriptional regulator YP_978593.1 2761274 R 410289 CDS YP_978594.1 121638370 4695615 complement(2764653..2764952) 1 NC_008769.1 hypothetical protein 2764952 4695615 BCG_2508c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978594.1 2764653 R 410289 CDS YP_978595.1 121638371 4695379 complement(2765061..2768513) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS43 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 8 bp insertion (*-gggggggg ) splits PE_PGRS43 into 2 parts, PE_PGRS43a and PE_PGRS43b while in Mycobacterium bovis BCG Pasteur, a 1 bp insertion (equivalent to Mycobacterium tuberculosis H37Rv position 2804942-2804943) causes a different frameshift but at same place; PE-PGRS family protein 2768513 PE_PGRS43b 4695379 PE_PGRS43b Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_978595.1 2765061 R 410289 CDS YP_978596.1 121638372 4695729 complement(2768605..2770032) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS43 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 8 bp insertion (*-gggggggg ) splits PE_PGRS43 into 2 parts, PE_PGRS43a and PE_PGRS43b while in Mycobacterium bovis BCG Pasteur, a 1 bp insertion (equivalent to Mycobacterium tuberculosis H37Rv position 2804942-2804943) causes a different frameshift but at same place; PE-PGRS family protein 2770032 PE_PGRS43a 4695729 PE_PGRS43a Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_978596.1 2768605 R 410289 CDS YP_978597.1 121638373 4695728 2770461..2771084 1 NC_008769.1 hypothetical protein 2771084 4695728 BCG_2511 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978597.1 2770461 D 410289 CDS YP_978598.1 121638374 4695577 2771074..2771826 1 NC_008769.1 Differs from Rv2492 by 1aa, D70A; hypothetical protein 2771826 4695577 BCG_2512 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978598.1 2771074 D 410289 CDS YP_978599.1 121638375 4695487 2771879..2772100 1 NC_008769.1 hypothetical protein 2772100 4695487 BCG_2513 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978599.1 2771879 D 410289 CDS YP_978600.1 121638376 4696245 2772106..2772531 1 NC_008769.1 hypothetical protein 2772531 4696245 BCG_2514 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978600.1 2772106 D 410289 CDS YP_978601.1 121638377 4697003 complement(2772554..2773735) 1 NC_008769.1 Differs from Rv2495c by 2aa, A107T, W208R; branched-chain alpha-keto acid dehydrogenase subunit E2 2773735 pdhC 4697003 pdhC Mycobacterium bovis BCG str. Pasteur 1173P2 branched-chain alpha-keto acid dehydrogenase subunit E2 YP_978601.1 2772554 R 410289 CDS YP_978602.1 121638378 4695741 complement(2773732..2774778) 1 NC_008769.1 Differs from Rv2496c by 1aa, S201G; pyruvate dehydrogenase E1 component subunit beta pdhB 2774778 pdhB 4695741 pdhB Mycobacterium bovis BCG str. Pasteur 1173P2 pyruvate dehydrogenase E1 component subunit beta pdhB YP_978602.1 2773732 R 410289 CDS YP_978603.1 121638379 4695740 complement(2774789..2775892) 1 NC_008769.1 pyruvate dehydrogenase E1 component subunit alpha pdhA 2775892 pdhA 4695740 pdhA Mycobacterium bovis BCG str. Pasteur 1173P2 pyruvate dehydrogenase E1 component subunit alpha pdhA YP_978603.1 2774789 R 410289 CDS YP_978604.1 121638380 4695739 complement(2776151..2776972) 1 NC_008769.1 citrate (pro-3s)-lyase subunit beta 2776972 citE 4695739 citE Mycobacterium bovis BCG str. Pasteur 1173P2 citrate (pro-3s)-lyase subunit beta YP_978604.1 2776151 R 410289 CDS YP_978605.1 121638381 4698379 complement(2776969..2777526) 1 NC_008769.1 oxidase regulatory-related protein 2777526 4698379 BCG_2519c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidase regulatory-related protein YP_978605.1 2776969 R 410289 CDS YP_978606.1 121638382 4696894 complement(2777523..2778707) 1 NC_008769.1 acyl-CoA dehydrogenase fadE19 2778707 fadE19 4696894 fadE19 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE19 YP_978606.1 2777523 R 410289 CDS YP_978607.1 121638383 4699117 complement(2778712..2780676) 1 NC_008769.1 acetyl-/propionyl-coenzyme A carboxylase alpha chain subunit alpha accA1 2780676 accA1 4699117 accA1 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-/propionyl-coenzyme A carboxylase alpha chain subunit alpha accA1 YP_978607.1 2778712 R 410289 CDS YP_978608.1 121638384 4698741 complement(2780681..2782270) 1 NC_008769.1 Differs from Rv2502c by 2aa, S77G, L343F; acetyl-/propionyl-coa carboxylase subunit beta accD1 2782270 accD1 4698741 accD1 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-/propionyl-coa carboxylase subunit beta accD1 YP_978608.1 2780681 R 410289 CDS YP_978609.1 121638385 4698737 complement(2782267..2782923) 1 NC_008769.1 succinyl-CoA:3-ketoacid-coenzyme A transferase subunit beta scoB 2782923 scoB 4698737 scoB Mycobacterium bovis BCG str. Pasteur 1173P2 succinyl-CoA:3-ketoacid-coenzyme A transferase subunit beta scoB YP_978609.1 2782267 R 410289 CDS YP_978610.1 121638386 4697897 complement(2782920..2783666) 1 NC_008769.1 succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha scoA 2783666 scoA 4697897 scoA Mycobacterium bovis BCG str. Pasteur 1173P2 succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha scoA YP_978610.1 2782920 R 410289 CDS YP_978611.1 121638387 4697896 complement(2783749..2785392) 1 NC_008769.1 activates fatty acids by binding to coenzyme A; AMP-binding protein 2785392 fadD35 4697896 fadD35 Mycobacterium bovis BCG str. Pasteur 1173P2 AMP-binding protein YP_978611.1 2783749 R 410289 CDS YP_978612.1 121638388 4697147 2785508..2786155 1 NC_008769.1 TetR family transcriptional regulator 2786155 4697147 BCG_2526 Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_978612.1 2785508 D 410289 CDS YP_978613.1 121638389 4698111 2786234..2787055 1 NC_008769.1 proline rich membrane protein 2787055 4698111 BCG_2527 Mycobacterium bovis BCG str. Pasteur 1173P2 proline rich membrane protein YP_978613.1 2786234 D 410289 CDS YP_978614.1 121638390 4696142 complement(2787052..2788389) 1 NC_008769.1 integral membrane leucine and alanine rich protein 2788389 4696142 BCG_2528c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane leucine and alanine rich protein YP_978614.1 2787052 R 410289 CDS YP_978615.1 121638391 4696687 2788474..2789280 1 NC_008769.1 short-chain type dehydrogenase/reductase 2789280 4696687 BCG_2529 Mycobacterium bovis BCG str. Pasteur 1173P2 short-chain type dehydrogenase/reductase YP_978615.1 2788474 D 410289 CDS YP_978616.1 121638392 4696838 complement(2789284..2790885) 1 NC_008769.1 hypothetical protein 2790885 4696838 BCG_2530c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978616.1 2789284 R 410289 CDS YP_978617.1 121638393 4698817 2790953..2791600 1 NC_008769.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 2791600 orn 4698817 orn Mycobacterium bovis BCG str. Pasteur 1173P2 oligoribonuclease YP_978617.1 2790953 D 410289 CDS YP_978618.1 121638394 4696331 complement(2792352..2793599) 1 NC_008769.1 transposase IS1081 2793599 4696331 BCG_2532c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase IS1081 YP_978618.1 2792352 R 410289 CDS YP_978619.1 121638395 4696380 2793599..2793736 1 NC_008769.1 hypothetical protein 2793736 4696380 BCG_2533 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978619.1 2793599 D 410289 CDS YP_978620.1 121638396 4696777 2793957..2794379 1 NC_008769.1 Differs from Rv2513 by 1aa, K122T; hypothetical protein 2794379 4696777 BCG_2534 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978620.1 2793957 D 410289 CDS YP_978621.1 121638397 4696362 complement(2794673..2795134) 1 NC_008769.1 hypothetical protein 2795134 4696362 BCG_2535c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978621.1 2794673 R 410289 CDS YP_978622.1 121638398 4698441 complement(2795140..2796387) 1 NC_008769.1 hypothetical protein 2796387 4698441 BCG_2536c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978622.1 2795140 R 410289 CDS YP_978623.1 121638399 4697838 complement(2796506..2797309) 1 NC_008769.1 hypothetical protein 2797309 4697838 BCG_2537c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978623.1 2796506 R 410289 CDS YP_978624.1 121638400 4698936 complement(2797306..2797557) 1 NC_008769.1 hypothetical protein 2797557 4698936 BCG_2538c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978624.1 2797306 R 410289 CDS YP_978625.1 121638401 4697743 complement(2797905..2799131) 1 NC_008769.1 lipoprotein lppS 2799131 lppS 4697743 lppS Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppS YP_978625.1 2797905 R 410289 CDS YP_978626.1 121638402 4697283 2799581..2801059 1 NC_008769.1 Identical to Rv2519 but differs from Mb2548 by 1aa, G173A, due to 2bp substitution at position equivalent to Mycobacterium bovis 2803099-2803100 cc-gg; PE family protein 2801059 PE26 4697283 PE26 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_978626.1 2799581 D 410289 CDS YP_978627.1 121638403 4697126 complement(2801184..2801411) 1 NC_008769.1 hypothetical protein 2801411 4697126 BCG_2541c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978627.1 2801184 R 410289 CDS YP_978628.1 121638404 4695599 2801480..2801953 1 NC_008769.1 Differs from Mb2550 by 1aa, V122M; bacterioferritin comigratory protein bcp 2801953 bcp 4695599 bcp Mycobacterium bovis BCG str. Pasteur 1173P2 bacterioferritin comigratory protein bcp YP_978628.1 2801480 D 410289 CDS YP_978629.1 121638405 4696638 complement(2801925..2803337) 1 NC_008769.1 hypothetical protein 2803337 4696638 BCG_2543c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978629.1 2801925 R 410289 CDS YP_978630.1 121638406 4696533 complement(2803334..2803726) 1 NC_008769.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 2803726 acpS 4696533 acpS Mycobacterium bovis BCG str. Pasteur 1173P2 4'-phosphopantetheinyl transferase YP_978630.1 2803334 R 410289 CDS YP_978631.1 121638407 4697832 complement(2803919..2813128) 1 NC_008769.1 fatty acid synthase fas 2813128 fas 4697832 fas Mycobacterium bovis BCG str. Pasteur 1173P2 fatty acid synthase fas YP_978631.1 2803919 R 410289 CDS YP_978632.1 121638408 4695683 complement(2813648..2814370) 1 NC_008769.1 hypothetical protein 2814370 4695683 BCG_2546c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978632.1 2813648 R 410289 CDS YP_978633.1 121638409 4696999 2814887..2815114 1 NC_008769.1 hypothetical protein 2815114 4696999 BCG_2547 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978633.1 2814887 D 410289 CDS YP_978634.1 121638410 4696071 2815111..2815512 1 NC_008769.1 hypothetical protein 2815512 4696071 BCG_2548 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978634.1 2815111 D 410289 CDS YP_978635.1 121638411 4698031 complement(2815547..2816467) 1 NC_008769.1 Differs from Rv2528c by 1aa, L94P, and Mb2557c by 2aa, L94P, E259Q; restriction system protein mrr 2816467 mrr 4698031 mrr Mycobacterium bovis BCG str. Pasteur 1173P2 restriction system protein mrr YP_978635.1 2815547 R 410289 CDS YP_978636.1 121638412 4698097 2816671..2818062 1 NC_008769.1 Differs from Mb2558 by 1aa, G94E; hypothetical protein 2818062 4698097 BCG_2550 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978636.1 2816671 D 410289 CDS YP_978637.1 121638413 4695744 complement(2818063..2818482) 1 NC_008769.1 hypothetical protein 2818482 4695744 BCG_2551c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978637.1 2818063 R 410289 CDS YP_978638.1 121638414 4697016 complement(2818479..2818703) 1 NC_008769.1 hypothetical protein 2818703 4697016 BCG_2552c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978638.1 2818479 R 410289 CDS YP_978639.1 121638415 4698187 complement(2818734..2821577) 1 NC_008769.1 amino acid decarboxylase 2821577 4698187 BCG_2553c Mycobacterium bovis BCG str. Pasteur 1173P2 amino acid decarboxylase YP_978639.1 2818734 R 410289 CDS YP_978640.1 121638416 4698448 complement(2821649..2822050) 1 NC_008769.1 hypothetical protein 2822050 4698448 BCG_2554c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978640.1 2821649 R 410289 CDS YP_978641.1 121638417 4697824 complement(2822050..2822520) 1 NC_008769.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 2822520 nusB 4697824 nusB Mycobacterium bovis BCG str. Pasteur 1173P2 transcription antitermination protein NusB YP_978641.1 2822050 R 410289 CDS YP_978642.1 121638418 4697206 complement(2822523..2823086) 1 NC_008769.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 2823086 efp 4697206 efp Mycobacterium bovis BCG str. Pasteur 1173P2 elongation factor P YP_978642.1 2822523 R 410289 CDS YP_978643.1 121638419 4697303 complement(2823096..2824214) 1 NC_008769.1 cytoplasmic peptidase pepQ 2824214 pepQ 4697303 pepQ Mycobacterium bovis BCG str. Pasteur 1173P2 cytoplasmic peptidase pepQ YP_978643.1 2823096 R 410289 CDS YP_978644.1 121638420 4696294 2824248..2824940 1 NC_008769.1 hypothetical protein 2824940 4696294 BCG_2558 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978644.1 2824248 D 410289 CDS YP_978645.1 121638421 4699191 complement(2824944..2825387) 1 NC_008769.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 2825387 aroD 4699191 aroD Mycobacterium bovis BCG str. Pasteur 1173P2 3-dehydroquinate dehydratase YP_978645.1 2824944 R 410289 CDS YP_978646.1 121638422 4696247 complement(2825384..2826472) 1 NC_008769.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 2826472 aroB 4696247 aroB Mycobacterium bovis BCG str. Pasteur 1173P2 3-dehydroquinate synthase YP_978646.1 2825384 R 410289 CDS YP_978647.1 121638423 4697902 complement(2826469..2826999) 1 NC_008769.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 2826999 aroK 4697902 aroK Mycobacterium bovis BCG str. Pasteur 1173P2 shikimate kinase YP_978647.1 2826469 R 410289 CDS YP_978648.1 121638424 4697459 complement(2827003..2828208) 1 NC_008769.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 2828208 aroF 4697459 aroF Mycobacterium bovis BCG str. Pasteur 1173P2 chorismate synthase YP_978648.1 2827003 R 410289 CDS YP_978649.1 121638425 4696606 2828223..2828630 1 NC_008769.1 hypothetical protein 2828630 4696606 BCG_2563 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978649.1 2828223 D 410289 CDS YP_978650.1 121638426 4698320 2828926..2830137 1 NC_008769.1 Differs from Rv2542 by 1aa, A211T; hypothetical protein 2830137 4698320 BCG_2564 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978650.1 2828926 D 410289 CDS YP_978651.1 121638427 4699122 2830264..2830923 1 NC_008769.1 lipoprotein lppA 2830923 lppA 4699122 lppA Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppA YP_978651.1 2830264 D 410289 CDS YP_978652.1 121638428 4699199 2830920..2831579 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, there is a 656 bp insertion, relative to Mycobacterium tuberculosis strain H37Rv, which leads to lppR gene, probably by duplication of llpA or lppB; lipoprotein lprR 2831579 lprR 4699199 lprR Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lprR YP_978652.1 2830920 D 410289 CDS YP_978653.1 121638429 4697258 2831576..2832238 1 NC_008769.1 lipoprotein lppB 2832238 lppB 4697258 lppB Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppB YP_978653.1 2831576 D 410289 CDS YP_978654.1 121638430 4699200 2832235..2832513 1 NC_008769.1 hypothetical protein 2832513 4699200 BCG_2568 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978654.1 2832235 D 410289 CDS YP_978655.1 121638431 4696592 2832606..2833019 1 NC_008769.1 hypothetical protein 2833019 4696592 BCG_2569 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978655.1 2832606 D 410289 CDS YP_978656.1 121638432 4699333 2833058..2833315 1 NC_008769.1 hypothetical protein 2833315 4699333 BCG_2570 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978656.1 2833058 D 410289 CDS YP_978657.1 121638433 4697065 2833312..2833689 1 NC_008769.1 hypothetical protein 2833689 4697065 BCG_2571 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978657.1 2833312 D 410289 CDS YP_978658.1 121638434 4695775 complement(2834179..2834574) 1 NC_008769.1 hypothetical protein 2834574 4695775 BCG_2572c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978658.1 2834179 R 410289 CDS YP_978659.1 121638435 4697634 complement(2834571..2834816) 1 NC_008769.1 hypothetical protein 2834816 4697634 BCG_2573c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978659.1 2834571 R 410289 CDS YP_978660.1 121638436 4697604 complement(2835227..2835646) 1 NC_008769.1 hypothetical protein 2835646 4697604 BCG_2574c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978660.1 2835227 R 410289 CDS YP_978661.2 229576791 4697739 complement(2835658..2836485) 1 NC_008769.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 2836485 aroE 4697739 aroE Mycobacterium bovis BCG str. Pasteur 1173P2 shikimate 5-dehydrogenase YP_978661.2 2835658 R 410289 CDS YP_978662.1 121638438 4699267 complement(2836463..2837716) 1 NC_008769.1 hypothetical protein 2837716 4699267 BCG_2576c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978662.1 2836463 R 410289 CDS YP_978663.1 121638439 4697454 complement(2837709..2838221) 1 NC_008769.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 2838221 4697454 BCG_2577c Mycobacterium bovis BCG str. Pasteur 1173P2 Holliday junction resolvase-like protein YP_978663.1 2837709 R 410289 CDS YP_978664.1 121638440 4696367 complement(2838222..2840936) 1 NC_008769.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 2840936 alaS 4696367 alaS Mycobacterium bovis BCG str. Pasteur 1173P2 alanyl-tRNA synthetase YP_978664.1 2838222 R 410289 CDS YP_978665.1 121638441 4695651 complement(2841027..2841416) 1 NC_008769.1 hypothetical protein 2841416 4695651 BCG_2579c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978665.1 2841027 R 410289 CDS YP_978666.1 121638442 4697332 2841523..2842197 1 NC_008769.1 hypothetical protein 2842197 4697332 BCG_2580 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978666.1 2841523 D 410289 CDS YP_978667.1 121638443 4695673 2842282..2842992 1 NC_008769.1 hypothetical protein 2842992 4695673 BCG_2581 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978667.1 2842282 D 410289 CDS YP_978668.1 121638444 4696480 complement(2843022..2844380) 1 NC_008769.1 Differs from Rv2559c by 1aa, D317G; recombination factor protein RarA 2844380 4696480 BCG_2582c Mycobacterium bovis BCG str. Pasteur 1173P2 recombination factor protein RarA YP_978668.1 2843022 R 410289 CDS YP_978669.1 121638445 4696725 2844526..2845503 1 NC_008769.1 Differs from Rv2560 by 1aa, L210V; proline and glycine rich transmembrane protein 2845503 4696725 BCG_2583 Mycobacterium bovis BCG str. Pasteur 1173P2 proline and glycine rich transmembrane protein YP_978669.1 2844526 D 410289 CDS YP_978670.1 121638446 4696692 2845860..2846597 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2561 and Rv2562 exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base deletion (g-*) results in a single product which is more similar to Rv2561; hypothetical protein 2846597 4696692 BCG_2584 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978670.1 2845860 D 410289 CDS YP_978671.1 121638447 4698429 2846740..2847789 1 NC_008769.1 glutamine-transport transmembrane protein ABC transporter 2847789 4698429 BCG_2585 Mycobacterium bovis BCG str. Pasteur 1173P2 glutamine-transport transmembrane protein ABC transporter YP_978671.1 2846740 D 410289 CDS YP_978672.1 121638448 4698399 2847792..2848784 1 NC_008769.1 glutamine-transport ATP-binding protein ABC transporter glnQ 2848784 glnQ 4698399 glnQ Mycobacterium bovis BCG str. Pasteur 1173P2 glutamine-transport ATP-binding protein ABC transporter glnQ YP_978672.1 2847792 D 410289 CDS YP_978673.1 121638449 4697948 2849061..2850812 1 NC_008769.1 hypothetical protein 2850812 4697948 BCG_2587 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978673.1 2849061 D 410289 CDS YP_978674.1 121638450 4697447 2850823..2852424 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 2 bp deletion (gc-*) splits Rv2566 into 2 parts. Differs from first part of Rv2566 by 3aa, S10G, S270A, L315V and from Mb2595 by 1aa, L315V; hypothetical protein 2852424 4697447 BCG_2588 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978674.1 2850823 D 410289 CDS YP_978675.1 121638451 4695373 2852450..2854243 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 2 bp deletion (gc-*) splits Rv2566 into 2 parts; Differs from Rv2566 by 2aa, P67L, E326G, and from Mb2596 by 1aa, E326G; hypothetical protein 2854243 4695373 BCG_2589 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978675.1 2852450 D 410289 CDS YP_978676.1 121638452 4696717 2854243..2856897 1 NC_008769.1 Differs from Rv2567 by 1aa, R645Q; hypothetical protein 2856897 4696717 BCG_2590 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978676.1 2854243 D 410289 CDS YP_978677.1 121638453 4698511 complement(2856894..2857919) 1 NC_008769.1 hypothetical protein 2857919 4698511 BCG_2591c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978677.1 2856894 R 410289 CDS YP_978678.1 121638454 4698987 complement(2857912..2858856) 1 NC_008769.1 hypothetical protein 2858856 4698987 BCG_2592c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978678.1 2857912 R 410289 CDS YP_978679.1 121638455 4698312 2858960..2859349 1 NC_008769.1 hypothetical protein 2859349 4698312 BCG_2593 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978679.1 2858960 D 410289 CDS YP_978680.1 121638456 4697295 complement(2859341..2860408) 1 NC_008769.1 Differs from Rv2571c and Mb2601c by 1aa, C68R; transmembrane alanine and valine and leucine rich protein 2860408 4697295 BCG_2594c Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane alanine and valine and leucine rich protein YP_978680.1 2859341 R 410289 CDS YP_978681.1 121638457 4697280 complement(2860415..2862250) 1 NC_008769.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 2862250 aspS 4697280 aspS Mycobacterium bovis BCG str. Pasteur 1173P2 aspartyl-tRNA synthetase YP_978681.1 2860415 R 410289 CDS YP_978682.1 121638458 4699328 2862490..2863230 1 NC_008769.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 2863230 4699328 BCG_2596 Mycobacterium bovis BCG str. Pasteur 1173P2 2-dehydropantoate 2-reductase YP_978682.1 2862490 D 410289 CDS YP_978683.1 121638459 4698814 2863253..2863756 1 NC_008769.1 hypothetical protein 2863756 4698814 BCG_2597 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978683.1 2863253 D 410289 CDS YP_978684.1 121638460 4698112 2863786..2864667 1 NC_008769.1 membrane glycine rich protein 2864667 4698112 BCG_2598 Mycobacterium bovis BCG str. Pasteur 1173P2 membrane glycine rich protein YP_978684.1 2863786 D 410289 CDS YP_978685.1 121638461 4695689 complement(2864673..2865137) 1 NC_008769.1 hypothetical protein 2865137 4695689 BCG_2599c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978685.1 2864673 R 410289 CDS YP_978686.1 121638462 4698029 2865365..2866954 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG Pasteur, Rv2577 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (g-a) splits Rv2577 into 2 parts, Mb2607 and Mb2608; hypothetical protein 2866954 4698029 BCG_2600 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978686.1 2865365 D 410289 CDS YP_978687.1 121638463 4698643 complement(2866956..2867978) 1 NC_008769.1 hypothetical protein 2867978 4698643 BCG_2601c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978687.1 2866956 R 410289 CDS YP_978688.1 121638464 4698043 2868086..2868988 1 NC_008769.1 catalyzes the cleavage of carbon-halogen bonds in aliphatic compounds forming a primary alcohol and a halide; haloalkane dehalogenase 2868988 dhaA 4698043 dhaA Mycobacterium bovis BCG str. Pasteur 1173P2 haloalkane dehalogenase YP_978688.1 2868086 D 410289 CDS YP_978689.1 121638465 4696840 complement(2869268..2870539) 1 NC_008769.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2870539 hisS 4696840 hisS Mycobacterium bovis BCG str. Pasteur 1173P2 histidyl-tRNA synthetase YP_978689.1 2869268 R 410289 CDS YP_978690.1 121638466 4696099 complement(2870536..2871210) 1 NC_008769.1 glyoxalase II 2871210 4696099 BCG_2604c Mycobacterium bovis BCG str. Pasteur 1173P2 glyoxalase II YP_978690.1 2870536 R 410289 CDS YP_978691.1 121638467 4697677 2871261..2872187 1 NC_008769.1 Differs from Rv2582 by 1aa, F66V; peptidyl-prolyl cis-trans isomerase B ppiB 2872187 ppiB 4697677 ppiB Mycobacterium bovis BCG str. Pasteur 1173P2 peptidyl-prolyl cis-trans isomerase B ppiB YP_978691.1 2871261 D 410289 CDS YP_978692.1 121638468 4698101 complement(2872273..2874645) 1 NC_008769.1 GTP pyrophosphokinase relA 2874645 relA 4698101 relA Mycobacterium bovis BCG str. Pasteur 1173P2 GTP pyrophosphokinase relA YP_978692.1 2872273 R 410289 CDS YP_978693.1 121638469 4696795 complement(2874676..2875347) 1 NC_008769.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 2875347 apt 4696795 apt Mycobacterium bovis BCG str. Pasteur 1173P2 adenine phosphoribosyltransferase YP_978693.1 2874676 R 410289 CDS YP_978694.1 121638470 4695940 complement(2875451..2877124) 1 NC_008769.1 Differs from Rv2585c by 1aa, S462C; lipoprotein 2877124 4695940 BCG_2608c Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein YP_978694.1 2875451 R 410289 CDS YP_978695.1 121638471 4699076 complement(2877130..2878458) 1 NC_008769.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 2878458 secF 4699076 secF Mycobacterium bovis BCG str. Pasteur 1173P2 preprotein translocase subunit SecF YP_978695.1 2877130 R 410289 CDS YP_978696.1 121638472 4697709 complement(2878462..2880183) 1 NC_008769.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 2880183 secD 4697709 secD Mycobacterium bovis BCG str. Pasteur 1173P2 preprotein translocase subunit SecD YP_978696.1 2878462 R 410289 CDS YP_978697.1 121638473 4697706 complement(2880293..2880640) 1 NC_008769.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 2880640 yajC 4697706 yajC Mycobacterium bovis BCG str. Pasteur 1173P2 preprotein translocase subunit YajC YP_978697.1 2880293 R 410289 CDS YP_978698.1 121638474 4696673 2880807..2882156 1 NC_008769.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2882156 gabT 4696673 gabT Mycobacterium bovis BCG str. Pasteur 1173P2 4-aminobutyrate aminotransferase YP_978698.1 2880807 D 410289 CDS YP_978699.1 121638475 4695551 2882318..2885824 1 NC_008769.1 Differs from Rv2590 by 1aa, Y309F, and from Mb2621 by 1aa, A1106T; fatty-acid-CoA ligase fadD9 2885824 fadD9 4695551 fadD9 Mycobacterium bovis BCG str. Pasteur 1173P2 fatty-acid-CoA ligase fadD9 YP_978699.1 2882318 D 410289 CDS YP_978700.1 121638476 4695871 2885998..2887638 1 NC_008769.1 Differs from Rv2591 by extra 3aa resulting from same 9 bp in-frame insertion as in Mycobacterium bovis (*-ggcggcacc) and by 2aa S415G, D463G; PE-PGRS family protein 2887638 PE_PGRS44 4695871 PE_PGRS44 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_978700.1 2885998 D 410289 CDS YP_978701.1 121638477 4695730 complement(2887655..2888689) 1 NC_008769.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 2888689 ruvB 4695730 ruvB Mycobacterium bovis BCG str. Pasteur 1173P2 Holliday junction DNA helicase RuvB YP_978701.1 2887655 R 410289 CDS YP_978702.1 121638478 4697807 complement(2888686..2889276) 1 NC_008769.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 2889276 ruvA 4697807 ruvA Mycobacterium bovis BCG str. Pasteur 1173P2 Holliday junction DNA helicase RuvA YP_978702.1 2888686 R 410289 CDS YP_978703.1 121638479 4697806 complement(2889273..2889839) 1 NC_008769.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 2889839 ruvC 4697806 ruvC Mycobacterium bovis BCG str. Pasteur 1173P2 Holliday junction resolvase YP_978703.1 2889273 R 410289 CDS YP_978704.1 121638480 4697808 2889948..2890193 1 NC_008769.1 hypothetical protein 2890193 4697808 BCG_2618 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978704.1 2889948 D 410289 CDS YP_978705.1 121638481 4698348 2890190..2890594 1 NC_008769.1 Differs from Rv2596 by 1aa, R77C; hypothetical protein 2890594 4698348 BCG_2619 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978705.1 2890190 D 410289 CDS YP_978706.1 121638482 4697394 2890811..2891431 1 NC_008769.1 hypothetical protein 2891431 4697394 BCG_2620 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978706.1 2890811 D 410289 CDS YP_978707.1 121638483 4697943 2891442..2891936 1 NC_008769.1 hypothetical protein 2891936 4697943 BCG_2621 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978707.1 2891442 D 410289 CDS YP_978708.1 121638484 4697014 2891933..2892364 1 NC_008769.1 Differs from Rv2599 by 1aa, I12S; hypothetical protein 2892364 4697014 BCG_2622 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978708.1 2891933 D 410289 CDS YP_978709.1 121638485 4697649 2892446..2892652 1 NC_008769.1 First 64 aa identical to N-terminal part of Rv2600 and Mb2631 but then frameshifts due to 10bp deletion at position equivalent to Mycobacterium bovis coordinates 2895640-2895649. Results in BCG Pasteur orthologs of Mb2631 and Rv2600 being in two parts; integral membrane protein 2892652 4697649 BCG_2623 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_978709.1 2892446 D 410289 CDS YP_978710.1 121638486 4698268 2892658..2892837 1 NC_008769.1 All 59aa are identical to C-terminal part of Rv2600 and Mb2631 owing to frameshifts due to 10bp deletion at position equivalent to Mycobacterium bovis coordinates 2895640-2895649. Results in BCG Pasteur orthologs of Mb2631 and Rv2600 being in two parts, both of which encode hydrophobic proteins; integral membrane protein 2892837 4698268 BCG_2624 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_978710.1 2892658 D 410289 CDS YP_978711.1 121638487 4696612 2892834..2894405 1 NC_008769.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 2894405 speE 4696612 speE Mycobacterium bovis BCG str. Pasteur 1173P2 spermidine synthase YP_978711.1 2892834 D 410289 CDS YP_978712.1 121638488 4695622 2894516..2894803 1 NC_008769.1 hypothetical protein 2894803 4695622 BCG_2626 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978712.1 2894516 D 410289 CDS YP_978713.1 121638489 4698327 2894790..2895230 1 NC_008769.1 hypothetical protein 2895230 4698327 BCG_2627 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978713.1 2894790 D 410289 CDS YP_978714.1 121638490 4698952 complement(2895251..2896006) 1 NC_008769.1 hypothetical protein 2896006 4698952 BCG_2628c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978714.1 2895251 R 410289 CDS YP_978715.1 121638491 4699057 complement(2896139..2896735) 1 NC_008769.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 2896735 4699057 BCG_2629c Mycobacterium bovis BCG str. Pasteur 1173P2 glutamine amidotransferase subunit PdxT YP_978715.1 2896139 R 410289 CDS YP_978716.1 121638492 4697047 complement(2896743..2897588) 1 NC_008769.1 Differs from Rv2605c by 1aa, L85F; acyl-CoA thioesterase II tesB2 2897588 tesB2 4697047 tesB2 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA thioesterase II tesB2 YP_978716.1 2896743 R 410289 CDS YP_978717.1 121638493 4696851 complement(2897617..2898516) 1 NC_008769.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 2898516 4696851 BCG_2631c Mycobacterium bovis BCG str. Pasteur 1173P2 pyridoxal biosynthesis lyase PdxS YP_978717.1 2897617 R 410289 CDS YP_978718.1 121638494 4695772 2898644..2899318 1 NC_008769.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 2899318 pdxH 4695772 pdxH Mycobacterium bovis BCG str. Pasteur 1173P2 pyridoxamine 5'-phosphate oxidase YP_978718.1 2898644 D 410289 CDS YP_978719.1 121638495 4695742 2899492..2901234 1 NC_008769.1 Differs from Rv2608 by 1aa, S281P; PPE family protein 2901234 PPE42 4695742 PPE42 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_978719.1 2899492 D 410289 CDS YP_978720.1 121638496 4697820 complement(2901256..2902311) 1 NC_008769.1 hypothetical protein 2902311 4697820 BCG_2634c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978720.1 2901256 R 410289 CDS YP_978721.1 121638497 4696309 complement(2902311..2903447) 1 NC_008769.1 Alpha-mannosyltransferase pimA 2903447 pimA 4696309 pimA Mycobacterium bovis BCG str. Pasteur 1173P2 Alpha-mannosyltransferase pimA YP_978721.1 2902311 R 410289 CDS YP_978722.1 121638498 4697039 complement(2903458..2904408) 1 NC_008769.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 2904408 4697039 BCG_2636c Mycobacterium bovis BCG str. Pasteur 1173P2 lipid A biosynthesis lauroyl acyltransferase YP_978722.1 2903458 R 410289 CDS YP_978723.1 121638499 4698001 complement(2904405..2905058) 1 NC_008769.1 phosphatidylinositol synthase pgsA1 2905058 pgsA1 4698001 pgsA1 Mycobacterium bovis BCG str. Pasteur 1173P2 phosphatidylinositol synthase pgsA1 YP_978723.1 2904405 R 410289 CDS YP_978724.1 121638500 4698856 complement(2905055..2905642) 1 NC_008769.1 hypothetical protein 2905642 4698856 BCG_2638c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978724.1 2905055 R 410289 CDS YP_978725.1 121638501 4698023 complement(2905635..2907713) 1 NC_008769.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 2907713 thrS 4698023 thrS Mycobacterium bovis BCG str. Pasteur 1173P2 threonyl-tRNA synthetase YP_978725.1 2905635 R 410289 CDS YP_978726.1 121638502 4695910 2907822..2908049 1 NC_008769.1 Differs from Mb2647 by 1aa, R57H; hypothetical protein 2908049 4695910 BCG_2640 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978726.1 2907822 D 410289 CDS YP_978727.1 121638503 4698252 complement(2908046..2909215) 1 NC_008769.1 In Mycobacterium bovis, a 9 bp in-frame insertion (*-ccgccgttt) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 461 aa). In Mycobacterium bovis BCG Pasteur, a 7bp deletion at position corresponding to M. bovis 2944835-2944841 splits PE_PGRS45 in two parts; PE-PGRS family protein 2909215 PE_PGRS45b 4698252 PE_PGRS45b Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_978727.1 2908046 R 410289 CDS YP_978728.1 121638504 4695666 complement(2909203..2909433) 1 NC_008769.1 In Mycobacterium bovis, a 9 bp in-frame insertion (*-ccgccgttt) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 461 aa). In Mycobacterium bovis BCG Pasteur, a 7bp deletion at position corresponding to M. bovis 2944835-2944841 splits PE_PGRS45 in two parts. Differs from Rv2615c by 1aa, V40A; PE-PGRS family protein 2909433 PE_PGRS45a 4695666 PE_PGRS45a Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_978728.1 2909203 R 410289 CDS YP_978729.1 121638505 4695665 2909778..2910278 1 NC_008769.1 Differs from Rv2616 by 1aa, I72V; hypothetical protein 2910278 4695665 BCG_2643 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978729.1 2909778 D 410289 CDS YP_978730.1 121638506 4698205 complement(2910295..2910735) 1 NC_008769.1 hypothetical protein 2910735 4698205 BCG_2644c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978730.1 2910295 R 410289 CDS YP_978731.1 121638507 4698136 2910882..2911559 1 NC_008769.1 hypothetical protein 2911559 4698136 BCG_2645 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978731.1 2910882 D 410289 CDS YP_978732.1 121638508 4698326 complement(2911544..2911897) 1 NC_008769.1 hypothetical protein 2911897 4698326 BCG_2646c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978732.1 2911544 R 410289 CDS YP_978733.1 121638509 4698162 complement(2911910..2912335) 1 NC_008769.1 hypothetical protein 2912335 4698162 BCG_2647c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978733.1 2911910 R 410289 CDS YP_978734.1 121638510 4698251 complement(2912332..2913003) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 3 bp deletion (ggg-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (223 aa versus 224 aa) due to deletion of 1aa after position 194; transcriptional regulatory protein 2913003 4698251 BCG_2648c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_978734.1 2912332 R 410289 CDS YP_978735.1 121638511 4698196 2913081..2913902 1 NC_008769.1 methyltransferase 2913902 4698196 BCG_2649 Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase YP_978735.1 2913081 D 410289 CDS YP_978736.1 121638512 4698189 2914038..2914931 1 NC_008769.1 hypothetical protein 2914931 TB31.7 4698189 TB31.7 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978736.1 2914038 D 410289 CDS YP_978737.1 121638513 4696423 complement(2914934..2915752) 1 NC_008769.1 hypothetical protein 2915752 4696423 BCG_2651c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978737.1 2914934 R 410289 CDS YP_978738.1 121638514 4698262 complement(2915767..2916948) 1 NC_008769.1 transmembrane alanine and leucine rich protein 2916948 4698262 BCG_2652c Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane alanine and leucine rich protein YP_978738.1 2915767 R 410289 CDS YP_978739.1 121638515 4697756 complement(2917007..2917438) 1 NC_008769.1 hypothetical protein 2917438 4697756 BCG_2653c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978739.1 2917007 R 410289 CDS YP_978740.1 121638516 4695421 complement(2917952..2919193) 1 NC_008769.1 Differs from Rv2627c by 1aa, G104R; hypothetical protein 2919193 4695421 BCG_2654c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978740.1 2917952 R 410289 CDS YP_978741.1 121638517 4698201 2919503..2919865 1 NC_008769.1 Differs from Rv2628 by 1aa, L59S, and from Mb2661 by 1aa, P68R; hypothetical protein 2919865 4698201 BCG_2655 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978741.1 2919503 D 410289 CDS YP_978742.1 121638518 4696239 2920212..2921336 1 NC_008769.1 hypothetical protein 2921336 4696239 BCG_2656 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978742.1 2920212 D 410289 CDS YP_978743.1 121638519 4696699 2921338..2921877 1 NC_008769.1 hypothetical protein 2921877 4696699 BCG_2657 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978743.1 2921338 D 410289 CDS YP_978744.1 121638520 4696601 2922016..2923314 1 NC_008769.1 hypothetical protein 2923314 4696601 BCG_2658 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978744.1 2922016 D 410289 CDS YP_978745.1 121638521 4699175 complement(2923353..2923634) 1 NC_008769.1 hypothetical protein 2923634 4699175 BCG_2659c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978745.1 2923353 R 410289 CDS YP_978746.1 121638522 4696801 complement(2923779..2924264) 1 NC_008769.1 hypothetical protein 2924264 4696801 BCG_2660c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978746.1 2923779 R 410289 CDS YP_978747.1 121638523 4697611 complement(2924549..2926951) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, an in-frame insertion of 66 bp, leads to a longer product compared to Mycobacterium bovis and Mycobacterium tuberculosis strain H37Rv (800 aa versus 778 aa); PE-PGRS family protein 2926951 PE_PGRS46 4697611 PE_PGRS46 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_978747.1 2924549 R 410289 CDS YP_978748.1 121638524 4695667 2926980..2927222 1 NC_008769.1 hypothetical protein 2927222 4695667 BCG_2662 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978748.1 2926980 D 410289 CDS YP_978749.1 121638525 4697377 2927223..2927900 1 NC_008769.1 hypothetical protein 2927900 4697377 BCG_2663 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978749.1 2927223 D 410289 CDS YP_978750.1 121638526 4695536 2928096..2928752 1 NC_008769.1 transmembrane protein dedA 2928752 dedA 4695536 dedA Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane protein dedA YP_978750.1 2928096 D 410289 CDS YP_978751.1 121638527 4696394 2928915..2929361 1 NC_008769.1 hypothetical protein 2929361 4696394 BCG_2665 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978751.1 2928915 D 410289 CDS YP_978752.1 121638528 4697060 complement(2929536..2929868) 1 NC_008769.1 hypothetical protein 2929868 4697060 BCG_2666c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978752.1 2929536 R 410289 CDS YP_978753.1 121638529 4696621 complement(2929988..2930347) 1 NC_008769.1 ArsR family transcriptional regulator 2930347 4696621 BCG_2667c Mycobacterium bovis BCG str. Pasteur 1173P2 ArsR family transcriptional regulator YP_978753.1 2929988 R 410289 CDS YP_978754.1 121638530 4695638 2930449..2930907 1 NC_008769.1 cadmium inducible protein cadI 2930907 cadI 4695638 cadI Mycobacterium bovis BCG str. Pasteur 1173P2 cadmium inducible protein cadI YP_978754.1 2930449 D 410289 CDS YP_978755.1 121638531 4696157 2931043..2931423 1 NC_008769.1 ArsR family transcriptional regulator 2931423 4696157 BCG_2669 Mycobacterium bovis BCG str. Pasteur 1173P2 ArsR family transcriptional regulator YP_978755.1 2931043 D 410289 CDS YP_978756.1 121638532 4696365 2931420..2932916 1 NC_008769.1 Differs from Rv2643 by 1 aa A455V; arsenic-transport integral membrane protein arsC 2932916 arsC 4696365 arsC Mycobacterium bovis BCG str. Pasteur 1173P2 arsenic-transport integral membrane protein arsC YP_978756.1 2931420 D 410289 CDS YP_978757.1 121638533 4695825 complement(2933043..2933360) 1 NC_008769.1 hypothetical protein 2933360 4695825 BCG_2671c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978757.1 2933043 R 410289 CDS YP_978758.1 121638534 4695656 complement(2934497..2934718) 1 NC_008769.1 In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a large 10982 bp deletion (RD11 region) leads to deletion of genes between Rv2645 and Rv2659c compared to Mycobacterium tuberculosis strain H37Rv; hypothetical protein 2934718 4695656 BCG_2672c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978758.1 2934497 R 410289 CDS YP_978759.1 121638535 4697341 complement(2934715..2935104) 1 NC_008769.1 hypothetical protein 2935104 4697341 BCG_2673c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978759.1 2934715 R 410289 CDS YP_978760.1 121638536 4695906 2935010..2935282 1 NC_008769.1 hypothetical protein 2935282 4695906 BCG_2674 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978760.1 2935010 D 410289 CDS YP_978761.1 121638537 4696835 2935381..2935614 1 NC_008769.1 hypothetical protein 2935614 4696835 BCG_2675 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978761.1 2935381 D 410289 CDS YP_978762.1 121638538 4696404 2935625..2935879 1 NC_008769.1 hypothetical protein 2935879 4696404 BCG_2676 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978762.1 2935625 D 410289 CDS YP_978763.1 121638539 4696812 complement(2936108..2936599) 1 NC_008769.1 hypothetical protein 2936599 4696812 BCG_2677c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978763.1 2936108 R 410289 CDS YP_978764.1 121638540 4697979 2936227..2936508 1 NC_008769.1 hypothetical protein 2936508 4697979 BCG_2678 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978764.1 2936227 D 410289 CDS YP_978765.1 121638541 4695869 2936599..2937402 1 NC_008769.1 transposase for insertion sequence element IS1081 2937402 4695869 BCG_2679 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase for insertion sequence element IS1081 YP_978765.1 2936599 D 410289 CDS YP_978766.1 121638542 4697616 2937424..2938182 1 NC_008769.1 ATP-dependent protease ATP-binding subunit clpX' 2938182 clpX' 4697616 clpX' Mycobacterium bovis BCG str. Pasteur 1173P2 ATP-dependent protease ATP-binding subunit clpX' YP_978766.1 2937424 D 410289 CDS YP_978767.1 121638543 4698514 2938261..2938782 1 NC_008769.1 Differs from Rv2668 by 2aa R3H and K162E; hypothetical protein 2938782 4698514 BCG_2681 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978767.1 2938261 D 410289 CDS YP_978768.1 121638544 4697567 2938811..2939281 1 NC_008769.1 hypothetical protein 2939281 4697567 BCG_2682 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978768.1 2938811 D 410289 CDS YP_978769.1 121638545 4696289 complement(2939259..2940368) 1 NC_008769.1 hypothetical protein 2940368 4696289 BCG_2683c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978769.1 2939259 R 410289 CDS YP_978770.1 121638546 4698423 2940367..2941143 1 NC_008769.1 hypothetical protein 2941143 ribD 4698423 ribD Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978770.1 2940367 D 410289 CDS YP_978771.1 121638547 4696891 2941210..2942796 1 NC_008769.1 Differs from Rv2672 by 1aa D317H; protease 2942796 4696891 BCG_2685 Mycobacterium bovis BCG str. Pasteur 1173P2 protease YP_978771.1 2941210 D 410289 CDS YP_978772.1 121638548 4696655 2942819..2944120 1 NC_008769.1 hypothetical protein 2944120 4696655 BCG_2686 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978772.1 2942819 D 410289 CDS YP_978773.1 121638549 4696721 2944289..2944699 1 NC_008769.1 hypothetical protein 2944699 4696721 BCG_2687 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978773.1 2944289 D 410289 CDS YP_978774.1 121638550 4699157 complement(2944767..2945519) 1 NC_008769.1 hypothetical protein 2945519 4699157 BCG_2688c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978774.1 2944767 R 410289 CDS YP_978775.1 121638551 4698800 complement(2945516..2946211) 1 NC_008769.1 hypothetical protein 2946211 4698800 BCG_2689c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978775.1 2945516 R 410289 CDS YP_978776.1 121638552 4699229 complement(2946217..2947575) 1 NC_008769.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX; protoporphyrinogen oxidase 2947575 hemY 4699229 hemY Mycobacterium bovis BCG str. Pasteur 1173P2 protoporphyrinogen oxidase YP_978776.1 2946217 R 410289 CDS YP_978777.1 121638553 4698931 complement(2947572..2948645) 1 NC_008769.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 2948645 hemE 4698931 hemE Mycobacterium bovis BCG str. Pasteur 1173P2 uroporphyrinogen decarboxylase YP_978777.1 2947572 R 410289 CDS YP_978778.1 121638554 4698904 2948698..2949528 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2949528 4698904 BCG_2692 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_978778.1 2948698 D 410289 CDS YP_978779.1 121638555 4698749 2949790..2950422 1 NC_008769.1 hypothetical protein 2950422 4698749 BCG_2693 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978779.1 2949790 D 410289 CDS YP_978780.1 121638556 4699141 2950424..2951740 1 NC_008769.1 Differs from Rv2681 by 1aa V196A; hypothetical protein 2951740 4699141 BCG_2694 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978780.1 2950424 D 410289 CDS YP_978781.1 121638557 4699174 complement(2951737..2953653) 1 NC_008769.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 2953653 dxs1 4699174 dxs1 Mycobacterium bovis BCG str. Pasteur 1173P2 1-deoxy-D-xylulose-5-phosphate synthase YP_978781.1 2951737 R 410289 CDS YP_978782.1 121638558 4696473 2953797..2954294 1 NC_008769.1 Differs from Rv2683 by 1aa, S84L; hypothetical protein 2954294 4696473 BCG_2696 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978782.1 2953797 D 410289 CDS YP_978783.1 121638559 4698992 2954299..2955588 1 NC_008769.1 arsenic-transport integral membrane protein arsA 2955588 arsA 4698992 arsA Mycobacterium bovis BCG str. Pasteur 1173P2 arsenic-transport integral membrane protein arsA YP_978783.1 2954299 D 410289 CDS YP_978784.1 121638560 4696729 2955668..2956954 1 NC_008769.1 Differs from Rv2685 by 1aa, G378A and Mb2704, by 1aa, G393C; arsenic-transport integral membrane protein arsB1 2956954 arsB1 4696729 arsB1 Mycobacterium bovis BCG str. Pasteur 1173P2 arsenic-transport integral membrane protein arsB1 YP_978784.1 2955668 D 410289 CDS YP_978785.1 121638561 4695346 complement(2956965..2957723) 1 NC_008769.1 antibiotic ABC transporter integral membrane protein 2957723 4695346 BCG_2699c Mycobacterium bovis BCG str. Pasteur 1173P2 antibiotic ABC transporter integral membrane protein YP_978785.1 2956965 R 410289 CDS YP_978786.1 121638562 4698704 complement(2957720..2958433) 1 NC_008769.1 antibiotic ABC transporter integral membrane protein 2958433 4698704 BCG_2700c Mycobacterium bovis BCG str. Pasteur 1173P2 antibiotic ABC transporter integral membrane protein YP_978786.1 2957720 R 410289 CDS YP_978787.1 121638563 4698672 complement(2958430..2959335) 1 NC_008769.1 Differs from Rv2688c by 1aa, T156P; antibiotic-transport ATP-binding protein ABC transporter 2959335 4698672 BCG_2701c Mycobacterium bovis BCG str. Pasteur 1173P2 antibiotic-transport ATP-binding protein ABC transporter YP_978787.1 2958430 R 410289 CDS YP_978788.1 121638564 4697977 complement(2959530..2960747) 1 NC_008769.1 hypothetical protein 2960747 4697977 BCG_2702c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978788.1 2959530 R 410289 CDS YP_978789.1 121638565 4698248 complement(2960903..2962894) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a single base transition (t-c) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (663 aa versus 657 aa); integral membrane alanine and valine and leucine rich protein 2962894 4698248 BCG_2703c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane alanine and valine and leucine rich protein YP_978789.1 2960903 R 410289 CDS YP_978790.1 121638566 4699242 2963029..2963712 1 NC_008769.1 Differs from Rv2691 by 1aa, A117T; TRK system potassium uptake protein ceoB 2963712 ceoB 4699242 ceoB Mycobacterium bovis BCG str. Pasteur 1173P2 TRK system potassium uptake protein ceoB YP_978790.1 2963029 D 410289 CDS YP_978791.1 121638567 4697668 2963709..2964371 1 NC_008769.1 Differs from Rv2692 by 1aa, V133I; TRK system potassium uptake protein ceoC 2964371 ceoC 4697668 ceoC Mycobacterium bovis BCG str. Pasteur 1173P2 TRK system potassium uptake protein ceoC YP_978791.1 2963709 D 410289 CDS YP_978792.1 121638568 4698048 complement(2964382..2965053) 1 NC_008769.1 integral membrane alanine and leucine rich protein 2965053 4698048 BCG_2706c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane alanine and leucine rich protein YP_978792.1 2964382 R 410289 CDS YP_978793.1 121638569 4699234 complement(2965084..2965452) 1 NC_008769.1 Differs from Rv2694c by 1aa, S68R; hypothetical protein 2965452 4699234 BCG_2707c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978793.1 2965084 R 410289 CDS YP_978794.1 121638570 4698249 2965601..2966308 1 NC_008769.1 hypothetical protein 2966308 4698249 BCG_2708 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978794.1 2965601 D 410289 CDS YP_978795.1 121638571 4698557 complement(2966514..2967293) 1 NC_008769.1 Differs from Rv2696c by 1aa, N164D; hypothetical protein 2967293 4698557 BCG_2709c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978795.1 2966514 R 410289 CDS YP_978796.1 121638572 4698537 complement(2967368..2967832) 1 NC_008769.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 2967832 dut 4698537 dut Mycobacterium bovis BCG str. Pasteur 1173P2 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_978796.1 2967368 R 410289 CDS YP_978797.1 121638573 4696429 2967858..2968343 1 NC_008769.1 alanine rich transmembrane protein 2968343 4696429 BCG_2711 Mycobacterium bovis BCG str. Pasteur 1173P2 alanine rich transmembrane protein YP_978797.1 2967858 D 410289 CDS YP_978798.1 121638574 4698626 complement(2968348..2968650) 1 NC_008769.1 hypothetical protein 2968650 4698626 BCG_2712c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978798.1 2968348 R 410289 CDS YP_978799.1 121638575 4699231 2968888..2969538 1 NC_008769.1 hypothetical protein 2969538 4699231 BCG_2713 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978799.1 2968888 D 410289 CDS YP_978800.1 121638576 4698883 complement(2969548..2970420) 1 NC_008769.1 extragenic suppressor protein suhB 2970420 suhB 4698883 suhB Mycobacterium bovis BCG str. Pasteur 1173P2 extragenic suppressor protein suhB YP_978800.1 2969548 R 410289 CDS YP_978801.1 121638577 4696336 2970543..2971340 1 NC_008769.1 Differs from Rv2702 by 1aa, T203I; polyphosphate glucokinase ppgK 2971340 ppgK 4696336 ppgK Mycobacterium bovis BCG str. Pasteur 1173P2 polyphosphate glucokinase ppgK YP_978801.1 2970543 D 410289 CDS YP_978802.1 121638578 4696419 2971520..2973106 1 NC_008769.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RNA polymerase sigma factor 2973106 sigA 4696419 sigA Mycobacterium bovis BCG str. Pasteur 1173P2 RNA polymerase sigma factor YP_978802.1 2971520 D 410289 CDS YP_978803.1 121638579 4696253 2973143..2973571 1 NC_008769.1 hypothetical protein 2973571 4696253 BCG_2717 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978803.1 2973143 D 410289 CDS YP_978804.1 121638580 4698893 complement(2973499..2973888) 1 NC_008769.1 hypothetical protein 2973888 4698893 BCG_2718c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978804.1 2973499 R 410289 CDS YP_978805.1 121638581 4696898 complement(2973885..2974142) 1 NC_008769.1 hypothetical protein 2974142 4696898 BCG_2719c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978805.1 2973885 R 410289 CDS YP_978806.1 121638582 4698925 2974258..2975232 1 NC_008769.1 transmembrane alanine and leucine rich protein 2975232 4698925 BCG_2720 Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane alanine and leucine rich protein YP_978806.1 2974258 D 410289 CDS YP_978807.1 121638583 4698926 complement(2975233..2975481) 1 NC_008769.1 hypothetical protein 2975481 4698926 BCG_2721c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978807.1 2975233 R 410289 CDS YP_978808.1 121638584 4698946 2975524..2975970 1 NC_008769.1 Differs from Rv2709 by 1aa, S35T; hypothetical protein 2975970 4698946 BCG_2722 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978808.1 2975524 D 410289 CDS YP_978809.1 121638585 4698951 2976146..2977117 1 NC_008769.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase; RNA polymerase sigma factor SigB 2977117 sigB 4698951 sigB Mycobacterium bovis BCG str. Pasteur 1173P2 RNA polymerase sigma factor SigB YP_978809.1 2976146 D 410289 CDS YP_978810.1 121638586 4695814 2977250..2977942 1 NC_008769.1 Iron-dependent repressor and activator ideR 2977942 ideR 4695814 ideR Mycobacterium bovis BCG str. Pasteur 1173P2 Iron-dependent repressor and activator ideR YP_978810.1 2977250 D 410289 CDS YP_978811.1 121638587 4699216 complement(2977955..2979013) 1 NC_008769.1 hypothetical protein 2979013 4699216 BCG_2725c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978811.1 2977955 R 410289 CDS YP_978812.1 121638588 4698960 2979126..2980532 1 NC_008769.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 2980532 sthA 4698960 sthA Mycobacterium bovis BCG str. Pasteur 1173P2 soluble pyridine nucleotide transhydrogenase YP_978812.1 2979126 D 410289 CDS YP_978813.1 121638589 4696756 2980750..2981724 1 NC_008769.1 Differs from Rv2714 by 2aa, W181S, A245V; hypothetical protein 2981724 4696756 BCG_2727 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978813.1 2980750 D 410289 CDS YP_978814.1 121638590 4698958 2981783..2982808 1 NC_008769.1 hydrolase 2982808 4698958 BCG_2728 Mycobacterium bovis BCG str. Pasteur 1173P2 hydrolase YP_978814.1 2981783 D 410289 CDS YP_978815.1 121638591 4698956 2982857..2983543 1 NC_008769.1 hypothetical protein 2983543 4698956 BCG_2729 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978815.1 2982857 D 410289 CDS YP_978816.1 121638592 4698943 complement(2983552..2984046) 1 NC_008769.1 hypothetical protein 2984046 4698943 BCG_2730c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978816.1 2983552 R 410289 CDS YP_978817.1 121638593 4698966 complement(2984098..2984562) 1 NC_008769.1 transcriptional regulator NrdR 2984562 nrdR 4698966 nrdR Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulator NrdR YP_978817.1 2984098 R 410289 CDS YP_978818.1 121638594 4698889 complement(2984725..2985222) 1 NC_008769.1 Differs from Rv2719c by 1aa, H124Y; hypothetical protein 2985222 4698889 BCG_2732c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978818.1 2984725 R 410289 CDS YP_978819.1 121638595 4698959 2985530..2986183 1 NC_008769.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 2986183 lexA 4698959 lexA Mycobacterium bovis BCG str. Pasteur 1173P2 LexA repressor YP_978819.1 2985530 D 410289 CDS YP_978820.1 121638596 4697486 complement(2986205..2988304) 1 NC_008769.1 Differs from Rv2721c and Mb2740c by 2aa, S251G, A326T; transmembrane alanine and glycine rich protein 2988304 4697486 BCG_2734c Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane alanine and glycine rich protein YP_978820.1 2986205 R 410289 CDS YP_978821.1 121638597 4698972 2988320..2988568 1 NC_008769.1 hypothetical protein 2988568 4698972 BCG_2735 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978821.1 2988320 D 410289 CDS YP_978822.1 121638598 4698967 2988594..2989787 1 NC_008769.1 integral membrane protein 2989787 4698967 BCG_2736 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_978822.1 2988594 D 410289 CDS YP_978823.1 121638599 4698954 complement(2989816..2990976) 1 NC_008769.1 Differs from Rv2724c by 1aa, T127I, and from Mb2743c by 1aa, P33A; acyl-CoA dehydrogenase fadE20 2990976 fadE20 4698954 fadE20 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE20 YP_978823.1 2989816 R 410289 CDS YP_978824.1 121638600 4699119 complement(2991112..2992599) 1 NC_008769.1 Differs from Rv2725c and Mb2744c by 1aa, D218G; GTP-binding protein hflX 2992599 hflX 4699119 hflX Mycobacterium bovis BCG str. Pasteur 1173P2 GTP-binding protein hflX YP_978824.1 2991112 R 410289 CDS YP_978825.1 121638601 4698933 complement(2992616..2993485) 1 NC_008769.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 2993485 dapF 4698933 dapF Mycobacterium bovis BCG str. Pasteur 1173P2 diaminopimelate epimerase YP_978825.1 2992616 R 410289 CDS YP_978826.1 121638602 4697823 complement(2993510..2994454) 1 NC_008769.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 2994454 miaA 4697823 miaA Mycobacterium bovis BCG str. Pasteur 1173P2 tRNA delta(2)-isopentenylpyrophosphate transferase YP_978826.1 2993510 R 410289 CDS YP_978827.1 121638603 4699002 complement(2994451..2995146) 1 NC_008769.1 hypothetical protein 2995146 4699002 BCG_2741c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978827.1 2994451 R 410289 CDS YP_978828.1 121638604 4697967 complement(2995255..2996160) 1 NC_008769.1 Differs from Rv2729c by 3aa, L41F, E202A, V266A; integral membrane alanine and valine and leucine rich protein 2996160 4697967 BCG_2742c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane alanine and valine and leucine rich protein YP_978828.1 2995255 R 410289 CDS YP_978829.1 121638605 4698982 2996227..2996703 1 NC_008769.1 hypothetical protein 2996703 4698982 BCG_2743 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978829.1 2996227 D 410289 CDS YP_978830.1 121638606 4698986 2996711..2998063 1 NC_008769.1 hypothetical protein 2998063 4698986 BCG_2744 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978830.1 2996711 D 410289 CDS YP_978831.1 121638607 4698997 complement(2998060..2998674) 1 NC_008769.1 hypothetical protein 2998674 4698997 BCG_2745c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978831.1 2998060 R 410289 CDS YP_978832.1 121638608 4698995 complement(2998671..3000209) 1 NC_008769.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 3000209 4698995 BCG_2746c Mycobacterium bovis BCG str. Pasteur 1173P2 (dimethylallyl)adenosine tRNA methylthiotransferase YP_978832.1 2998671 R 410289 CDS YP_978833.1 121638609 4699013 3000506..3001360 1 NC_008769.1 hypothetical protein 3001360 4699013 BCG_2747 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978833.1 3000506 D 410289 CDS YP_978834.1 121638610 4698998 complement(3001245..3002237) 1 NC_008769.1 hypothetical protein 3002237 4698998 BCG_2748c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978834.1 3001245 R 410289 CDS YP_978835.1 121638611 4699027 complement(3002247..3002771) 1 NC_008769.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 3002771 recX 4699027 recX Mycobacterium bovis BCG str. Pasteur 1173P2 recombination regulator RecX YP_978835.1 3002247 R 410289 CDS YP_978836.1 121638612 4695841 complement(3002737..3005109) 1 NC_008769.1 these RecA proteins contain inteins; catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; DNA recombination protein RecA 3005109 recA 4695841 recA Mycobacterium bovis BCG str. Pasteur 1173P2 DNA recombination protein RecA YP_978836.1 3002737 R 410289 CDS YP_978837.1 121638613 4697309 3005304..3005477 1 NC_008769.1 hypothetical protein 3005477 4697309 BCG_2751 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978837.1 3005304 D 410289 CDS YP_978838.1 121638614 4699018 complement(3005491..3005697) 1 NC_008769.1 hypothetical protein 3005697 4699018 BCG_2752c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978838.1 3005491 R 410289 CDS YP_978839.1 121638615 4699026 complement(3005708..3006874) 1 NC_008769.1 alanine rich transferase 3006874 4699026 BCG_2753c Mycobacterium bovis BCG str. Pasteur 1173P2 alanine rich transferase YP_978839.1 3005708 R 410289 CDS YP_978840.1 121638616 4699034 3006918..3007367 1 NC_008769.1 epoxide hydrolase 3007367 ephG 4699034 ephG Mycobacterium bovis BCG str. Pasteur 1173P2 epoxide hydrolase YP_978840.1 3006918 D 410289 CDS YP_978842.1 121638618 4695669 3007643..3008917 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, deletions of a single base (t-*) and of 84 bp (H37Rv2.3054724-3054807-*) leads to a shorter product with a different 5' start compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Also has lost 174 bp compared to Mb2761; PE-PGRS family protein 3008917 PE_PGRS47 4695669 PE_PGRS47 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_978842.1 3007643 D 410289 CDS YP_978843.1 121638619 4695668 complement(3008941..3009189) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2742c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a 23 bp insertion splits Rv2742c into two parts; hypothetical protein 3009189 4695668 BCG_2757c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978843.1 3008941 R 410289 CDS YP_978844.1 121638620 4697969 complement(3009210..3009797) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2742c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a 23 bp insertion splits Rv2742c into two parts; hypothetical protein 3009797 4697969 BCG_2758c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978844.1 3009210 R 410289 CDS YP_978845.1 121638621 4699035 complement(3009869..3010681) 1 NC_008769.1 membrane alanine rich protein 3010681 4699035 BCG_2759c Mycobacterium bovis BCG str. Pasteur 1173P2 membrane alanine rich protein YP_978845.1 3009869 R 410289 CDS YP_978846.1 121638622 4699045 complement(3010700..3011512) 1 NC_008769.1 Differs from Mb2765c by 1aa, K153Q; hypothetical protein 3011512 35kd_ag 4699045 35kd_ag Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978846.1 3010700 R 410289 CDS YP_978847.1 121638623 4698659 complement(3011642..3011980) 1 NC_008769.1 transcriptional regulatory protein 3011980 4698659 BCG_2761c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_978847.1 3011642 R 410289 CDS YP_978848.1 121638624 4699038 complement(3012051..3012680) 1 NC_008769.1 pgp synthase pgsA3 3012680 pgsA3 4699038 pgsA3 Mycobacterium bovis BCG str. Pasteur 1173P2 pgp synthase pgsA3 YP_978848.1 3012051 R 410289 CDS YP_978849.1 121638625 4698858 3012711..3013235 1 NC_008769.1 catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis; N-acetylglutamate synthase 3013235 4698858 BCG_2763 Mycobacterium bovis BCG str. Pasteur 1173P2 N-acetylglutamate synthase YP_978849.1 3012711 D 410289 CDS YP_978850.1 121638626 4699047 complement(3013304..3015955) 1 NC_008769.1 cell division transmembrane protein ftsK 3015955 ftsK 4699047 ftsK Mycobacterium bovis BCG str. Pasteur 1173P2 cell division transmembrane protein ftsK YP_978850.1 3013304 R 410289 CDS YP_978851.1 121638627 4695823 3015954..3016268 1 NC_008769.1 hypothetical protein 3016268 4695823 BCG_2765 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978851.1 3015954 D 410289 CDS YP_978852.1 121638628 4699055 3016265..3017083 1 NC_008769.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 3017083 4699055 BCG_2766 Mycobacterium bovis BCG str. Pasteur 1173P2 3-ketoacyl-ACP reductase YP_978852.1 3016265 D 410289 CDS YP_978853.1 121638629 4699028 3017087..3017977 1 NC_008769.1 hypothetical protein 3017977 4699028 BCG_2767 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978853.1 3017087 D 410289 CDS YP_978854.1 121638630 4698452 complement(3017964..3019640) 1 NC_008769.1 hypothetical protein 3019640 4698452 BCG_2768c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978854.1 3017964 R 410289 CDS YP_978855.1 121638631 4699062 complement(3019671..3020573) 1 NC_008769.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 3020573 dapA 4699062 dapA Mycobacterium bovis BCG str. Pasteur 1173P2 dihydrodipicolinate synthase YP_978855.1 3019671 R 410289 CDS YP_978856.1 121638632 4697475 complement(3020642..3021394) 1 NC_008769.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase 3021394 thyX 4697475 thyX Mycobacterium bovis BCG str. Pasteur 1173P2 FAD-dependent thymidylate synthase YP_978856.1 3020642 R 410289 CDS YP_978857.1 121638633 4699070 complement(3021638..3021913) 1 NC_008769.1 type I restriction/modification system specificity determinant hsdS' 3021913 hsdS' 4699070 hsdS' Mycobacterium bovis BCG str. Pasteur 1173P2 type I restriction/modification system specificity determinant hsdS' YP_978857.1 3021638 R 410289 CDS YP_978858.1 121638634 4697338 complement(3021910..3023532) 1 NC_008769.1 Differs from Rv2756c by 1aa, P306L; type I restriction/modification system DNA methylase hsdM 3023532 hsdM 4697338 hsdM Mycobacterium bovis BCG str. Pasteur 1173P2 type I restriction/modification system DNA methylase hsdM YP_978858.1 3021910 R 410289 CDS YP_978859.1 121638635 4697336 complement(3023619..3024035) 1 NC_008769.1 hypothetical protein 3024035 4697336 BCG_2773c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978859.1 3023619 R 410289 CDS YP_978860.1 121638636 4699066 complement(3024032..3024298) 1 NC_008769.1 hypothetical protein 3024298 4699066 BCG_2774c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978860.1 3024032 R 410289 CDS YP_978861.1 121638637 4699081 complement(3024324..3024719) 1 NC_008769.1 hypothetical protein 3024719 4699081 BCG_2775c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978861.1 3024324 R 410289 CDS YP_978862.1 121638638 4698473 complement(3024716..3024985) 1 NC_008769.1 hypothetical protein 3024985 4698473 BCG_2776c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978862.1 3024716 R 410289 CDS YP_978863.1 121638639 4699082 complement(3024995..3026089) 1 NC_008769.1 type I restriction/modification system specificity determinant hsdS 3026089 hsdS 4699082 hsdS Mycobacterium bovis BCG str. Pasteur 1173P2 type I restriction/modification system specificity determinant hsdS YP_978863.1 3024995 R 410289 CDS YP_978864.1 121638640 4697337 complement(3026086..3026358) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2762c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transition (c-t) splits Rv2762c into 2 parts; hypothetical protein 3026358 4697337 BCG_2778c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978864.1 3026086 R 410289 CDS YP_978865.1 121638641 4699073 complement(3026374..3026505) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv2762c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base transition (c-t) splits Rv2762c into 2 parts; hypothetical protein 3026505 4699073 BCG_2779c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978865.1 3026374 R 410289 CDS YP_978866.1 121638642 4699078 complement(3026579..3027058) 1 NC_008769.1 dihydrofolate reductase dfrA 3027058 dfrA 4699078 dfrA Mycobacterium bovis BCG str. Pasteur 1173P2 dihydrofolate reductase dfrA YP_978866.1 3026579 R 410289 CDS YP_978867.1 121638643 4697134 complement(3027129..3027920) 1 NC_008769.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 3027920 thyA 4697134 thyA Mycobacterium bovis BCG str. Pasteur 1173P2 thymidylate synthase YP_978867.1 3027129 R 410289 CDS YP_978868.1 121638644 4695911 3028085..3028822 1 NC_008769.1 Differs from Rv2765 and Mb2787 by 1aa, I129M; alanine rich hydrolase 3028822 4695911 BCG_2782 Mycobacterium bovis BCG str. Pasteur 1173P2 alanine rich hydrolase YP_978868.1 3028085 D 410289 CDS YP_978869.1 121638645 4699091 complement(3029037..3029819) 1 NC_008769.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 3029819 fabG 4699091 fabG Mycobacterium bovis BCG str. Pasteur 1173P2 3-ketoacyl-ACP reductase YP_978869.1 3029037 R 410289 CDS YP_978870.1 121638646 4699094 complement(3029816..3030169) 1 NC_008769.1 Differs from Rv2767c and Mb2789c by 1aa, L26S; hypothetical protein 3030169 4699094 BCG_2784c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978870.1 3029816 R 410289 CDS YP_978871.1 121638647 4699080 complement(3030343..3031527) 1 NC_008769.1 Differs from Rv2768c by 1aa, R263P; PPE family protein 3031527 PPE43 4699080 PPE43 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_978871.1 3030343 R 410289 CDS YP_978872.1 121638648 4697821 complement(3031607..3032434) 1 NC_008769.1 Differs from Rv2769c by 2aa, S54P, M270V; PE family protein 3032434 PE27 4697821 PE27 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_978872.1 3031607 R 410289 CDS YP_978873.1 121638649 4697127 complement(3032758..3033906) 1 NC_008769.1 Differs from Rv2770c by 1aa, S194F; PPE family protein 3033906 PPE44 4697127 PPE44 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_978873.1 3032758 R 410289 CDS YP_978874.1 121638650 4697822 complement(3034030..3034482) 1 NC_008769.1 Differs from Rv2771c by 1aa, P80L; hypothetical protein 3034482 4697822 BCG_2788c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978874.1 3034030 R 410289 CDS YP_978875.1 121638651 4699069 complement(3034568..3035041) 1 NC_008769.1 hypothetical protein 3035041 4699069 BCG_2789c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978875.1 3034568 R 410289 CDS YP_978876.1 121638652 4699108 complement(3035053..3035790) 1 NC_008769.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 3035790 dapB 4699108 dapB Mycobacterium bovis BCG str. Pasteur 1173P2 dihydrodipicolinate reductase YP_978876.1 3035053 R 410289 CDS YP_978877.1 121638653 4696260 complement(3035801..3036205) 1 NC_008769.1 hypothetical protein 3036205 4696260 BCG_2791c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978877.1 3035801 R 410289 CDS YP_978878.1 121638654 4699130 3036358..3036819 1 NC_008769.1 hypothetical protein 3036819 4699130 BCG_2792 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978878.1 3036358 D 410289 CDS YP_978879.1 121638655 4699086 complement(3036823..3037752) 1 NC_008769.1 oxidoreductase 3037752 4699086 BCG_2793c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_978879.1 3036823 R 410289 CDS YP_978880.1 121638656 4699146 complement(3037934..3039004) 1 NC_008769.1 hypothetical protein 3039004 4699146 BCG_2794c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978880.1 3037934 R 410289 CDS YP_978881.1 121638657 4699159 complement(3039162..3039632) 1 NC_008769.1 hypothetical protein 3039632 4699159 BCG_2795c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978881.1 3039162 R 410289 CDS YP_978882.1 121638658 4699140 complement(3039664..3040203) 1 NC_008769.1 In Mycobacterium bovis, a 24 bp deletion leads to a shorter product compared to its homolog in Mycobacterium bovis BCG Pasteur, and Mycobacterium tuberculosis strain H37Rv (171 aa versus 179 aa); Differs from Rv2779c by 1aa, I9M, and 8 aa longer than Mb2801c; lrp/asnC family transcriptional regulator 3040203 4699140 BCG_2796c Mycobacterium bovis BCG str. Pasteur 1173P2 lrp/asnC family transcriptional regulator YP_978882.1 3039664 R 410289 CDS YP_978883.1 121638659 4699143 3040269..3040667 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis BCG Pasteur, and in Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits ald into 2 parts, ald_a and aldb; L-alanine dehydrogenase 3040667 ald_a 4699143 ald_a Mycobacterium bovis BCG str. Pasteur 1173P2 L-alanine dehydrogenase YP_978883.1 3040269 D 410289 CDS YP_978884.1 121638660 4696993 3040664..3041383 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis BCG Pasteur, and in Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits ald into 2 parts, ald_a and aldb; L-alanine dehydrogenase 3041383 aldb 4696993 aldb Mycobacterium bovis BCG str. Pasteur 1173P2 L-alanine dehydrogenase YP_978884.1 3040664 D 410289 CDS YP_978885.1 121638661 4696662 complement(3041398..3042432) 1 NC_008769.1 alanine rich oxidoreductase 3042432 4696662 BCG_2799c Mycobacterium bovis BCG str. Pasteur 1173P2 alanine rich oxidoreductase YP_978885.1 3041398 R 410289 CDS YP_978886.1 121638662 4699147 complement(3042493..3043809) 1 NC_008769.1 zinc protease pepR 3043809 pepR 4699147 pepR Mycobacterium bovis BCG str. Pasteur 1173P2 zinc protease pepR YP_978886.1 3042493 R 410289 CDS YP_978887.1 121638663 4696295 complement(3043787..3046045) 1 NC_008769.1 polynucleotide phosphorylase 3046045 gpsI 4696295 gpsI Mycobacterium bovis BCG str. Pasteur 1173P2 polynucleotide phosphorylase YP_978887.1 3043787 R 410289 CDS YP_978888.1 121638664 4697843 complement(3046399..3046914) 1 NC_008769.1 hypothetical protein 3046914 lppU 4697843 lppU Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978888.1 3046399 R 410289 CDS YP_978889.1 121638665 4698578 complement(3046927..3047196) 1 NC_008769.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 3047196 rpsO 4698578 rpsO Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S15 YP_978889.1 3046927 R 410289 CDS YP_978890.1 121638666 4698853 complement(3047353..3048348) 1 NC_008769.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 3048348 ribF 4698853 ribF Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional riboflavin kinase/FMN adenylyltransferase YP_978890.1 3047353 R 410289 CDS YP_978891.1 121638667 4695901 3048559..3050322 1 NC_008769.1 Differs from Rv2787 and Mb2810 by 1aa, P78T; hypothetical protein 3050322 4695901 BCG_2805 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978891.1 3048559 D 410289 CDS YP_978892.1 121638668 4699165 3050407..3051093 1 NC_008769.1 Differs from Rv2788 by 1aa, A137D; transcriptional repressor sirR 3051093 sirR 4699165 sirR Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional repressor sirR YP_978892.1 3050407 D 410289 CDS YP_978893.1 121638669 4697290 complement(3051154..3052386) 1 NC_008769.1 acyl-CoA dehydrogenase fadE21 3052386 fadE21 4697290 fadE21 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE21 YP_978893.1 3051154 R 410289 CDS YP_978894.1 121638670 4699120 complement(3052412..3053617) 1 NC_008769.1 lipid-transfer protein 3053617 ltp1 4699120 ltp1 Mycobacterium bovis BCG str. Pasteur 1173P2 lipid-transfer protein YP_978894.1 3052412 R 410289 CDS YP_978895.1 121638671 4697261 complement(3053650..3055029) 1 NC_008769.1 transposase 3055029 4697261 BCG_2809c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_978895.1 3053650 R 410289 CDS YP_978896.1 121638672 4699162 complement(3055029..3055610) 1 NC_008769.1 Differs from Mb2815c by 2aa, A17V, T80E; resolvase 3055610 4699162 BCG_2810c Mycobacterium bovis BCG str. Pasteur 1173P2 resolvase YP_978896.1 3055029 R 410289 CDS YP_978897.1 121638673 4699176 complement(3055812..3056708) 1 NC_008769.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 3056708 truB 4699176 truB Mycobacterium bovis BCG str. Pasteur 1173P2 tRNA pseudouridine synthase B YP_978897.1 3055812 R 410289 CDS YP_978898.1 121638674 4696830 complement(3056705..3057388) 1 NC_008769.1 Differs from Rv2794c by 1aa, V87M; hypothetical protein 3057388 4696830 BCG_2812c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978898.1 3056705 R 410289 CDS YP_978899.1 121638675 4699170 complement(3057385..3058359) 1 NC_008769.1 hypothetical protein 3058359 4699170 BCG_2813c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978899.1 3057385 R 410289 CDS YP_978900.1 121638676 4699177 complement(3058504..3059067) 1 NC_008769.1 Differs from Rv2796c by 1aa, F159C; lipoprotein lppV 3059067 lppV 4699177 lppV Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppV YP_978900.1 3058504 R 410289 CDS YP_978901.1 121638677 4698579 complement(3059067..3060755) 1 NC_008769.1 hypothetical protein 3060755 4698579 BCG_2815c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978901.1 3059067 R 410289 CDS YP_978902.1 121638678 4699178 complement(3060759..3061085) 1 NC_008769.1 hypothetical protein 3061085 4699178 BCG_2816c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978902.1 3060759 R 410289 CDS YP_978903.1 121638679 4699181 3061216..3061845 1 NC_008769.1 In Mycobacterium bovis, a 3 bp insertion (*-ggt) leads to a slightly longer product compared to its homolog in Mycobacterium bovis BCG Pasteur and Mycobacterium tuberculosis strain H37Rv (210 aa versus 209 aa); hypothetical protein 3061845 4699181 BCG_2817 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978903.1 3061216 D 410289 CDS YP_978904.1 121638680 4699190 3061864..3063513 1 NC_008769.1 hydrolase 3063513 4699190 BCG_2818 Mycobacterium bovis BCG str. Pasteur 1173P2 hydrolase YP_978904.1 3061864 D 410289 CDS YP_978905.1 121638681 4699172 complement(3063615..3063971) 1 NC_008769.1 hypothetical protein 3063971 4699172 BCG_2819c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978905.1 3063615 R 410289 CDS YP_978906.1 121638682 4699167 complement(3064228..3065271) 1 NC_008769.1 hypothetical protein 3065271 4699167 BCG_2820c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978906.1 3064228 R 410289 CDS YP_978907.1 121638683 4698955 3065270..3065737 1 NC_008769.1 hypothetical protein 3065737 4698955 BCG_2821 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978907.1 3065270 D 410289 CDS YP_978908.1 121638684 4698106 complement(3065913..3066542) 1 NC_008769.1 Differs from Rv2804c by 2aa, T58A, V74A; hypothetical protein 3066542 4698106 BCG_2822c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978908.1 3065913 R 410289 CDS YP_978909.1 121638685 4699197 3066315..3066719 1 NC_008769.1 Differs from Rv2805 by 1aa, D4G; hypothetical protein 3066719 4699197 BCG_2823 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978909.1 3066315 D 410289 CDS YP_978910.1 121638686 4699208 3066716..3066907 1 NC_008769.1 hypothetical protein 3066907 4699208 BCG_2824 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978910.1 3066716 D 410289 CDS YP_978911.1 121638687 4699233 3067106..3068260 1 NC_008769.1 Differs from Rv2807 by 2aa, V72E, T349M, and from Mb2830 by 1aa, T349M; hypothetical protein 3068260 4699233 BCG_2825 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978911.1 3067106 D 410289 CDS YP_978912.1 121638688 4699223 3068494..3068751 1 NC_008769.1 hypothetical protein 3068751 4699223 BCG_2826 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978912.1 3068494 D 410289 CDS YP_978913.1 121638689 4699237 3068856..3069167 1 NC_008769.1 Differs from Rv2809 by 1aa, P46T; hypothetical protein 3069167 4699237 BCG_2827 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978913.1 3068856 D 410289 CDS YP_978914.1 121638690 4699270 3069587..3070195 1 NC_008769.1 hypothetical protein 3070195 4699270 BCG_2829 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978914.1 3069587 D 410289 CDS YP_978915.1 121638691 4699261 3070266..3071675 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur and in Mycobacterium tuberculosis strain H37Rv, Rv2812 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (tg-*) splits Rv2812 into 2 parts, Mb2835 and Mb2836. Differs from Rv2812 by 1 aa, G395R; transposase 3071675 4699261 BCG_2830 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_978915.1 3070266 D 410289 CDS YP_978916.1 121638692 4699263 3071672..3072484 1 NC_008769.1 Differs from Rv2813 by 1aa, V76I; hypothetical protein 3072484 4699263 BCG_2831 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978916.1 3071672 D 410289 CDS YP_978917.1 121638693 4699244 complement(3074087..3074923) 1 NC_008769.1 transposase 3074923 4699244 BCG_2832c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_978917.1 3074087 R 410289 CDS YP_978918.1 121638694 4699271 complement(3075022..3075348) 1 NC_008769.1 transposase 3075348 4699271 BCG_2833c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_978918.1 3075022 R 410289 CDS YP_978919.1 121638695 4699257 complement(3077602..3077943) 1 NC_008769.1 hypothetical protein 3077943 4699257 BCG_2834c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978919.1 3077602 R 410289 CDS YP_978920.1 121638696 4695859 complement(3077944..3078960) 1 NC_008769.1 hypothetical protein 3078960 4695859 BCG_2835c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978920.1 3077944 R 410289 CDS YP_978921.1 121638697 4698069 complement(3079210..3080220) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transition (c-t) introduces a premature stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (336 aa versus 382 aa); hypothetical protein 3080220 4698069 BCG_2837c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978921.1 3079210 R 410289 CDS YP_978922.1 121638698 4698363 complement(3080217..3081344) 1 NC_008769.1 hypothetical protein 3081344 4698363 BCG_2838c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978922.1 3080217 R 410289 CDS YP_978923.1 121638699 4698091 complement(3081341..3082249) 1 NC_008769.1 hypothetical protein 3082249 4698091 BCG_2839c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978923.1 3081341 R 410289 CDS YP_978924.1 121638700 4698470 complement(3082230..3082940) 1 NC_008769.1 hypothetical protein 3082940 4698470 BCG_2840c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978924.1 3082230 R 410289 CDS YP_978925.1 121638701 4698757 complement(3082950..3083324) 1 NC_008769.1 hypothetical protein 3083324 4698757 BCG_2841c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978925.1 3082950 R 410289 CDS YP_978926.1 121638702 4699158 complement(3083321..3085759) 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 9 bp insertion (*-cggcgatgt) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv; hypothetical protein 3085759 4699158 BCG_2842c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978926.1 3083321 R 410289 CDS YP_978927.1 121638703 4698051 complement(3085756..3086700) 1 NC_008769.1 Differs from Mb2848c by 1aa H56P; hypothetical protein 3086700 4698051 BCG_2843c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978927.1 3085756 R 410289 CDS YP_978928.1 121638704 4698523 complement(3086878..3087525) 1 NC_008769.1 Differs from Rv2825c by 5aa, E2K, C162S, L189V, Q192T, E195A; hypothetical protein 3087525 4698523 BCG_2844c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978928.1 3086878 R 410289 CDS YP_978929.1 121638705 4698411 complement(3087695..3088579) 1 NC_008769.1 hypothetical protein 3088579 4698411 BCG_2845c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978929.1 3087695 R 410289 CDS YP_978930.1 121638706 4698486 complement(3088582..3089469) 1 NC_008769.1 hypothetical protein 3089469 4698486 BCG_2846c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978930.1 3088582 R 410289 CDS YP_978931.1 121638707 4698315 complement(3089774..3090319) 1 NC_008769.1 Differs from Mb2852c by 1aa E58A; hypothetical protein 3090319 4698315 BCG_2847c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978931.1 3089774 R 410289 CDS YP_978932.1 121638708 4698227 complement(3090316..3090585) 1 NC_008769.1 hypothetical protein 3090585 4698227 BCG_2848c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978932.1 3090316 R 410289 CDS YP_978933.1 121638709 4698072 complement(3090606..3090998) 1 NC_008769.1 hypothetical protein 3090998 4698072 BCG_2849c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978933.1 3090606 R 410289 CDS YP_978934.1 121638710 4698184 complement(3090995..3091210) 1 NC_008769.1 Differs from Rv2830c by 1aa, V56A; hypothetical protein 3091210 4698184 BCG_2850c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978934.1 3090995 R 410289 CDS YP_978935.1 121638711 4698203 3091257..3092006 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 3092006 echA16 4698203 echA16 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_978935.1 3091257 D 410289 CDS YP_978936.1 121638712 4695716 complement(3092085..3093167) 1 NC_008769.1 Differs from Rv2832c and Mb2856c by 1aa, L235F; sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter ugpC 3093167 ugpC 4695716 ugpC Mycobacterium bovis BCG str. Pasteur 1173P2 sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter ugpC YP_978936.1 3092085 R 410289 CDS YP_978937.1 121638713 4697192 complement(3093838..3094470) 1 NC_008769.1 In mycobacterium bovis BCG Pasteur, a single base mutation (T->A) at corresponding position 3093840, in Mycobacterium tuberculosis H37Rv strain, leads to a stop codon and break ugpB in two parts. Differs from Rv2833c by 2aa, I111S, L174P; sn-glycerol-3-phosphate-binding lipoprotein ugpB 3094470 ugpBa 4697192 ugpBa Mycobacterium bovis BCG str. Pasteur 1173P2 sn-glycerol-3-phosphate-binding lipoprotein ugpB YP_978937.1 3093838 R 410289 CDS YP_978938.1 121638714 4697191 complement(3094473..3095300) 1 NC_008769.1 sn-glycerol-3-phosphate transport integral membrane protein ABC transporter ugpE 3095300 ugpE 4697191 ugpE Mycobacterium bovis BCG str. Pasteur 1173P2 sn-glycerol-3-phosphate transport integral membrane protein ABC transporter ugpE YP_978938.1 3094473 R 410289 CDS YP_978939.1 121638715 4697194 complement(3095297..3096208) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur and Mycobacterium tuberculosis strain H37Rv, ugpA exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) splits ugpA into 2 parts, ugpAa and ugpAb; sn-glycerol-3-phosphate transport integral membrane protein ABC transporter ugpA 3096208 ugpA 4697194 ugpA Mycobacterium bovis BCG str. Pasteur 1173P2 sn-glycerol-3-phosphate transport integral membrane protein ABC transporter ugpA YP_978939.1 3095297 R 410289 CDS YP_978940.1 121638716 4697190 complement(3096295..3097614) 1 NC_008769.1 Differs from Rv2836c by 2aa, H157Q, L350P, and from Mb2861c by 1aa, H157Q; DNA-damage-inducible protein F dinF 3097614 dinF 4697190 dinF Mycobacterium bovis BCG str. Pasteur 1173P2 DNA-damage-inducible protein F dinF YP_978940.1 3096295 R 410289 CDS YP_978941.1 121638717 4695491 complement(3097621..3098631) 1 NC_008769.1 hypothetical protein 3098631 4695491 BCG_2857c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978941.1 3097621 R 410289 CDS YP_978942.1 121638718 4699316 complement(3098606..3099157) 1 NC_008769.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 3099157 rbfA 4699316 rbfA Mycobacterium bovis BCG str. Pasteur 1173P2 ribosome-binding factor A YP_978942.1 3098606 R 410289 CDS YP_978943.1 121638719 4697306 complement(3099157..3101859) 1 NC_008769.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 3101859 infB 4697306 infB Mycobacterium bovis BCG str. Pasteur 1173P2 translation initiation factor IF-2 YP_978943.1 3099157 R 410289 CDS YP_978944.1 121638720 4697074 complement(3101945..3102244) 1 NC_008769.1 hypothetical protein 3102244 4697074 BCG_2860c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978944.1 3101945 R 410289 CDS YP_978945.1 121638721 4699059 complement(3102371..3103414) 1 NC_008769.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 3103414 nusA 4699059 nusA Mycobacterium bovis BCG str. Pasteur 1173P2 transcription elongation factor NusA YP_978945.1 3102371 R 410289 CDS YP_978946.1 121638722 4697205 complement(3103411..3103962) 1 NC_008769.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 3103962 4697205 BCG_2862c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978946.1 3103411 R 410289 CDS YP_978947.1 121638723 4698608 3104157..3104702 1 NC_008769.1 transmembrane alanine rich protein 3104702 4698608 BCG_2863 Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane alanine rich protein YP_978947.1 3104157 D 410289 CDS YP_978948.1 121638724 4698135 3104699..3105187 1 NC_008769.1 hypothetical protein 3105187 4698135 BCG_2864 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978948.1 3104699 D 410289 CDS YP_978949.1 121638725 4699164 complement(3105188..3106936) 1 NC_008769.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 3106936 proS 4699164 proS Mycobacterium bovis BCG str. Pasteur 1173P2 prolyl-tRNA synthetase YP_978949.1 3105188 R 410289 CDS YP_978950.1 121638726 4696515 complement(3107025..3108617) 1 NC_008769.1 Differs from Rv2846c by 1aa, R15T; integral membrane efflux protein efpA 3108617 efpA 4696515 efpA Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane efflux protein efpA YP_978950.1 3107025 R 410289 CDS YP_978951.1 121638727 4695779 complement(3108640..3109857) 1 NC_008769.1 multifunctional enzyme siroheme synthase cysG: uroporphyrin-III c-methyltransferase + precorrin-2 oxidase + ferrochelatase 3109857 cysG 4695779 cysG Mycobacterium bovis BCG str. Pasteur 1173P2 multifunctional enzyme siroheme synthase cysG: uroporphyrin-III c-methyltransferase + precorrin-2 oxidase + ferrochelatase YP_978951.1 3108640 R 410289 CDS YP_978952.1 121638728 4697918 complement(3110134..3111507) 1 NC_008769.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid; cobyrinic acid a,c-diamide synthase 3111507 cobB 4697918 cobB Mycobacterium bovis BCG str. Pasteur 1173P2 cobyrinic acid a,c-diamide synthase YP_978952.1 3110134 R 410289 CDS YP_978953.1 121638729 4698658 complement(3111507..3112130) 1 NC_008769.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 3112130 cobO 4698658 cobO Mycobacterium bovis BCG str. Pasteur 1173P2 cob(I)yrinic acid a,c-diamide adenosyltransferase YP_978953.1 3111507 R 410289 CDS YP_978954.1 121638730 4697938 complement(3112151..3114040) 1 NC_008769.1 Differs from Rv2850c by 2aa, Q273R, S446G; magnesium chelatase 3114040 4697938 BCG_2870c Mycobacterium bovis BCG str. Pasteur 1173P2 magnesium chelatase YP_978954.1 3112151 R 410289 CDS YP_978955.1 121638731 4699370 complement(3114037..3114507) 1 NC_008769.1 hypothetical protein 3114507 4699370 BCG_2871c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978955.1 3114037 R 410289 CDS YP_978956.1 121638732 4698212 complement(3114566..3116047) 1 NC_008769.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 3116047 mqo 4698212 mqo Mycobacterium bovis BCG str. Pasteur 1173P2 malate:quinone oxidoreductase YP_978956.1 3114566 R 410289 CDS YP_978957.1 121638733 4698095 3116254..3118047 1 NC_008769.1 Differs from Rv2853 by 3aa, N227K, G228R, D232G, and 18aa deletion, and from Mb2878 by 1aa, D184G, and same 18aa deletion; PE-PGRS family protein 3118047 PE_PGRS48 4698095 PE_PGRS48 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_978957.1 3116254 D 410289 CDS YP_978958.1 121638734 4695717 3118084..3119124 1 NC_008769.1 hypothetical protein 3119124 4695717 BCG_2874 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978958.1 3118084 D 410289 CDS YP_978959.1 121638735 4699358 3119137..3120516 1 NC_008769.1 catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide; mycothione reductase 3120516 mtr 4699358 mtr Mycobacterium bovis BCG str. Pasteur 1173P2 mycothione reductase YP_978959.1 3119137 D 410289 CDS YP_978960.1 121638736 4699148 3120616..3121734 1 NC_008769.1 nickel-transport integral membrane protein nicT 3121734 nicT 4699148 nicT Mycobacterium bovis BCG str. Pasteur 1173P2 nickel-transport integral membrane protein nicT YP_978960.1 3120616 D 410289 CDS YP_978961.1 121638737 4699204 3121800..3122132 1 NC_008769.1 hypothetical protein 3122132 4699204 BCG_2877 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978961.1 3121800 D 410289 CDS YP_978962.1 121638738 4698219 3122144..3122359 1 NC_008769.1 hypothetical protein 3122359 4698219 BCG_2878 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978962.1 3122144 D 410289 CDS YP_978963.1 121638739 4699235 complement(3122515..3123291) 1 NC_008769.1 short chain dehydrogenase 3123291 4699235 BCG_2879c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_978963.1 3122515 R 410289 CDS YP_978964.1 121638740 4698471 complement(3123288..3124655) 1 NC_008769.1 aldehyde dehydrogenase aldC 3124655 aldC 4698471 aldC Mycobacterium bovis BCG str. Pasteur 1173P2 aldehyde dehydrogenase aldC YP_978964.1 3123288 R 410289 CDS YP_978965.1 121638741 4696737 complement(3124652..3125578) 1 NC_008769.1 amidotransferase 3125578 4696737 BCG_2881c Mycobacterium bovis BCG str. Pasteur 1173P2 amidotransferase YP_978965.1 3124652 R 410289 CDS YP_978966.1 121638742 4698322 complement(3125559..3126932) 1 NC_008769.1 glutamine synthetase 3126932 glnA4 4698322 glnA4 Mycobacterium bovis BCG str. Pasteur 1173P2 glutamine synthetase YP_978966.1 3125559 R 410289 CDS YP_978967.1 121638743 4696212 complement(3127092..3127949) 1 NC_008769.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential; methionine aminopeptidase 3127949 mapB 4696212 mapB Mycobacterium bovis BCG str. Pasteur 1173P2 methionine aminopeptidase YP_978967.1 3127092 R 410289 CDS YP_978968.1 121638744 4698662 complement(3127991..3128575) 1 NC_008769.1 Differs from Rv2862c by 2aa, P18R, R50C; hypothetical protein 3128575 4698662 BCG_2884c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978968.1 3127991 R 410289 CDS YP_978969.1 121638745 4699232 3128924..3129304 1 NC_008769.1 hypothetical protein 3129304 4699232 BCG_2885 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978969.1 3128924 D 410289 CDS YP_978970.1 121638746 4698222 complement(3129386..3131197) 1 NC_008769.1 penicillin-binding lipoprotein 3131197 4698222 BCG_2886c Mycobacterium bovis BCG str. Pasteur 1173P2 penicillin-binding lipoprotein YP_978970.1 3129386 R 410289 CDS YP_978971.1 121638747 4699364 3131469..3131750 1 NC_008769.1 hypothetical protein 3131750 4699364 BCG_2887 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978971.1 3131469 D 410289 CDS YP_978972.1 121638748 4698477 3131754..3132017 1 NC_008769.1 hypothetical protein 3132017 4698477 BCG_2888 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978972.1 3131754 D 410289 CDS YP_978973.1 121638749 4698991 complement(3132390..3133244) 1 NC_008769.1 hypothetical protein 3133244 4698991 BCG_2889c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978973.1 3132390 R 410289 CDS YP_978974.1 121638750 4699179 complement(3133300..3134463) 1 NC_008769.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 3134463 ispG 4699179 ispG Mycobacterium bovis BCG str. Pasteur 1173P2 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_978974.1 3133300 R 410289 CDS YP_978975.1 121638751 4696530 complement(3134480..3135694) 1 NC_008769.1 Differs from Mb2894c by 1aa, T330A, and from Rv2869c by 2aa, F259V, T330A; hypothetical protein 3135694 4696530 BCG_2891c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978975.1 3134480 R 410289 CDS YP_978976.1 121638752 4698567 complement(3135702..3136943) 1 NC_008769.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 3136943 dxr 4698567 dxr Mycobacterium bovis BCG str. Pasteur 1173P2 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_978976.1 3135702 R 410289 CDS YP_978977.1 121638753 4697006 3137070..3137327 1 NC_008769.1 hypothetical protein 3137327 4697006 BCG_2893 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978977.1 3137070 D 410289 CDS YP_978978.1 121638754 4698899 3137314..3137757 1 NC_008769.1 Differs from Rv2872 and Mb2897 by 1aa, T72A; hypothetical protein 3137757 4698899 BCG_2894 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978978.1 3137314 D 410289 CDS YP_978979.1 121638755 4699266 3137837..3138499 1 NC_008769.1 cell surface lipoprotein mpb83 3138499 mpb83 4699266 mpb83 Mycobacterium bovis BCG str. Pasteur 1173P2 cell surface lipoprotein mpb83 YP_978979.1 3137837 D 410289 CDS YP_978980.1 121638756 4696125 3138779..3140866 1 NC_008769.1 Differs from Rv2874 by 1aa, D672Y; integral membrane C-type cytochrome biogenesis protein dipZ 3140866 dipZ 4696125 dipZ Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane C-type cytochrome biogenesis protein dipZ YP_978980.1 3138779 D 410289 CDS YP_978981.1 121638757 4696775 3140962..3141543 1 NC_008769.1 hypothetical protein 3141543 mpb70 4696775 mpb70 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978981.1 3140962 D 410289 CDS YP_978982.1 121638758 4696124 3141595..3141909 1 NC_008769.1 Differs from Mb2901 by 1aa, D101G, and from Rv2876 by 2aa, R44W, D101G; hypothetical protein 3141909 4696124 BCG_2898 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978982.1 3141595 D 410289 CDS YP_978983.1 121638759 4698224 complement(3141940..3142803) 1 NC_008769.1 Differs from Rv2877c by 1aa, H35Y; integral membrane protein 3142803 4698224 BCG_2899c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_978983.1 3141940 R 410289 CDS YP_978984.1 121638760 4699363 complement(3142808..3143329) 1 NC_008769.1 hypothetical protein 3143329 mpb53 4699363 mpb53 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978984.1 3142808 R 410289 CDS YP_978985.1 121638761 4696123 complement(3143515..3144609) 1 NC_008769.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 3144609 4696123 BCG_2901c Mycobacterium bovis BCG str. Pasteur 1173P2 ribosomal RNA large subunit methyltransferase N YP_978985.1 3143515 R 410289 CDS YP_978986.1 121638762 4698206 complement(3144632..3145552) 1 NC_008769.1 integral membrane phosphatidate cytidylyltransferase cdsA 3145552 cdsA 4698206 cdsA Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane phosphatidate cytidylyltransferase cdsA YP_978986.1 3144632 R 410289 CDS YP_978987.1 121638763 4697650 complement(3145575..3146132) 1 NC_008769.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 3146132 frr 4697650 frr Mycobacterium bovis BCG str. Pasteur 1173P2 ribosome recycling factor YP_978987.1 3145575 R 410289 CDS YP_978988.1 121638764 4695820 complement(3146304..3147089) 1 NC_008769.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 3147089 pyrH 4695820 pyrH Mycobacterium bovis BCG str. Pasteur 1173P2 uridylate kinase YP_978988.1 3146304 R 410289 CDS YP_978989.1 121638765 4697787 3147324..3148082 1 NC_008769.1 transcriptional regulatory protein 3148082 4697787 BCG_2905 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_978989.1 3147324 D 410289 CDS YP_978990.1 121638766 4698168 complement(3148161..3149480) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-c) leads to a truncation resulting in a shorter product compared to its homolog in Mycobacterium tuberculosis stain H37Rv (439 aa versus 460 aa); transposase 3149480 4698168 BCG_2906c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_978990.1 3148161 R 410289 CDS YP_978991.1 121638767 4699195 complement(3149477..3150364) 1 NC_008769.1 resolvase 3150364 4699195 BCG_2907c Mycobacterium bovis BCG str. Pasteur 1173P2 resolvase YP_978991.1 3149477 R 410289 CDS YP_978992.1 121638768 4699283 3150363..3150782 1 NC_008769.1 transcriptional regulatory protein 3150782 4699283 BCG_2908 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_978992.1 3150363 D 410289 CDS YP_978993.1 121638769 4698195 complement(3150796..3152217) 1 NC_008769.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 3152217 amiC 4698195 amiC Mycobacterium bovis BCG str. Pasteur 1173P2 amidase YP_978993.1 3150796 R 410289 CDS YP_978994.1 121638770 4697868 complement(3152224..3153039) 1 NC_008769.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 3153039 tsf 4697868 tsf Mycobacterium bovis BCG str. Pasteur 1173P2 elongation factor Ts YP_978994.1 3152224 R 410289 CDS YP_978995.1 121638771 4697089 complement(3153051..3153914) 1 NC_008769.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 3153914 rpsB 4697089 rpsB Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S2 YP_978995.1 3153051 R 410289 CDS YP_978996.1 121638772 4697296 3154198..3154947 1 NC_008769.1 hypothetical protein 3154947 4697296 BCG_2912 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_978996.1 3154198 D 410289 CDS YP_978997.1 121638773 4698691 complement(3154726..3155952) 1 NC_008769.1 PPE family protein 3155952 PPE45 4698691 PPE45 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_978997.1 3154726 R 410289 CDS YP_978998.1 121638774 4696405 3156352..3157329 1 NC_008769.1 oxidoreductase 3157329 4696405 BCG_2914 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_978998.1 3156352 D 410289 CDS YP_978999.1 121638775 4698624 complement(3157326..3158222) 1 NC_008769.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 3158222 xerC 4698624 xerC Mycobacterium bovis BCG str. Pasteur 1173P2 site-specific tyrosine recombinase XerC YP_978999.1 3157326 R 410289 CDS YP_979000.1 121638776 4697554 complement(3158313..3159164) 1 NC_008769.1 mycobactin utilization protein viuB 3159164 viuB 4697554 viuB Mycobacterium bovis BCG str. Pasteur 1173P2 mycobactin utilization protein viuB YP_979000.1 3158313 R 410289 CDS YP_979001.1 121638777 4697887 complement(3159197..3160366) 1 NC_008769.1 Differs from Rv2896c by 2aa, G57E, A153S; hypothetical protein 3160366 4697887 BCG_2917c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979001.1 3159197 R 410289 CDS YP_979002.1 121638778 4698275 complement(3160363..3161874) 1 NC_008769.1 hypothetical protein 3161874 4698275 BCG_2918c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979002.1 3160363 R 410289 CDS YP_979003.1 121638779 4698073 complement(3161874..3162260) 1 NC_008769.1 hypothetical protein 3162260 4698073 BCG_2919c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979003.1 3161874 R 410289 CDS YP_979004.1 121638780 4698357 complement(3162508..3163338) 1 NC_008769.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 3163338 fdhD 4698357 fdhD Mycobacterium bovis BCG str. Pasteur 1173P2 formate dehydrogenase accessory protein YP_979004.1 3162508 R 410289 CDS YP_979005.1 121638781 4696524 complement(3163338..3165677) 1 NC_008769.1 formate dehydrogenase H fdhF 3165677 fdhF 4696524 fdhF Mycobacterium bovis BCG str. Pasteur 1173P2 formate dehydrogenase H fdhF YP_979005.1 3163338 R 410289 CDS YP_979006.1 121638782 4696525 complement(3165735..3166040) 1 NC_008769.1 hypothetical protein 3166040 4696525 BCG_2922c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979006.1 3165735 R 410289 CDS YP_979007.1 121638783 4698220 complement(3166094..3166888) 1 NC_008769.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 3166888 rnhB 4698220 rnhB Mycobacterium bovis BCG str. Pasteur 1173P2 ribonuclease HII YP_979007.1 3166094 R 410289 CDS YP_979008.1 121638784 4697608 complement(3166902..3167786) 1 NC_008769.1 Differs from Rv2903c by 1aa, N2564D; signal peptidase I lepB 3167786 lepB 4697608 lepB Mycobacterium bovis BCG str. Pasteur 1173P2 signal peptidase I lepB YP_979008.1 3166902 R 410289 CDS YP_979009.1 121638785 4695957 complement(3167844..3168185) 1 NC_008769.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 3168185 rplS 4695957 rplS Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L19 YP_979009.1 3167844 R 410289 CDS YP_979010.1 121638786 4695879 3168560..3169504 1 NC_008769.1 alanine rich lipoprotein lppW 3169504 lppW 4695879 lppW Mycobacterium bovis BCG str. Pasteur 1173P2 alanine rich lipoprotein lppW YP_979010.1 3168560 D 410289 CDS YP_979011.1 121638787 4698580 complement(3169597..3170289) 1 NC_008769.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 3170289 trmD 4698580 trmD Mycobacterium bovis BCG str. Pasteur 1173P2 tRNA (guanine-N(1)-)-methyltransferase YP_979011.1 3169597 R 410289 CDS YP_979012.1 121638788 4697329 complement(3170293..3170823) 1 NC_008769.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 3170823 rimM 4697329 rimM Mycobacterium bovis BCG str. Pasteur 1173P2 16S rRNA-processing protein RimM YP_979012.1 3170293 R 410289 CDS YP_979013.1 121638789 4695582 complement(3170837..3171079) 1 NC_008769.1 hypothetical protein 3171079 4695582 BCG_2929c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979013.1 3170837 R 410289 CDS YP_979014.1 121638790 4698383 complement(3171087..3171575) 1 NC_008769.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 3171575 rpsP 4698383 rpsP Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S16 YP_979014.1 3171087 R 410289 CDS YP_979015.1 121638791 4695805 complement(3171759..3172202) 1 NC_008769.1 hypothetical protein 3172202 4695805 BCG_2931c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979015.1 3171759 R 410289 CDS YP_979016.1 121638792 4699374 3172271..3173146 1 NC_008769.1 D-alanyl-D-alanine carboxypeptidase 3173146 dacB2 4699374 dacB2 Mycobacterium bovis BCG str. Pasteur 1173P2 D-alanyl-D-alanine carboxypeptidase YP_979016.1 3172271 D 410289 CDS YP_979017.1 121638793 4695939 complement(3173206..3173793) 1 NC_008769.1 TetR family transcriptional regulator 3173793 4695939 BCG_2933c Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_979017.1 3173206 R 410289 CDS YP_979018.1 121638794 4699357 complement(3173795..3175630) 1 NC_008769.1 D-amino acid aminohydrolase 3175630 4699357 BCG_2934c Mycobacterium bovis BCG str. Pasteur 1173P2 D-amino acid aminohydrolase YP_979018.1 3173795 R 410289 CDS YP_979019.1 121638795 4699286 complement(3175699..3177456) 1 NC_008769.1 transmembrane serine/threonine-protein kinase I pknI 3177456 pknI 4699286 pknI Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane serine/threonine-protein kinase I pknI YP_979019.1 3175699 R 410289 CDS YP_979020.1 121638796 4697524 complement(3177500..3178612) 1 NC_008769.1 hypothetical protein 3178612 4697524 BCG_2936c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979020.1 3177500 R 410289 CDS YP_979021.1 121638797 4699180 complement(3178640..3180217) 1 NC_008769.1 signal recognition particle protein ffh 3180217 ffh 4699180 ffh Mycobacterium bovis BCG str. Pasteur 1173P2 signal recognition particle protein ffh YP_979021.1 3178640 R 410289 CDS YP_979022.1 121638798 4695364 3180295..3182175 1 NC_008769.1 Differs from Rv2917 by 1aa, L594R; hypothetical protein 3182175 4695364 BCG_2938 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979022.1 3180295 D 410289 CDS YP_979023.1 121638799 4698068 complement(3182186..3184612) 1 NC_008769.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; also involved in adenylylating and deadelnylyating GlnK; PII uridylyl-transferase 3184612 glnD 4698068 glnD Mycobacterium bovis BCG str. Pasteur 1173P2 PII uridylyl-transferase YP_979023.1 3182186 R 410289 CDS YP_979024.1 121638800 4697945 complement(3184670..3185008) 1 NC_008769.1 nitrogen regulatory protein P-II glnB 3185008 glnB 4697945 glnB Mycobacterium bovis BCG str. Pasteur 1173P2 nitrogen regulatory protein P-II glnB YP_979024.1 3184670 R 410289 CDS YP_979025.1 121638801 4697944 complement(3185005..3186438) 1 NC_008769.1 ammonium-transport integral membrane protein amt 3186438 amt 4697944 amt Mycobacterium bovis BCG str. Pasteur 1173P2 ammonium-transport integral membrane protein amt YP_979025.1 3185005 R 410289 CDS YP_979026.1 121638802 4698243 complement(3186915..3188183) 1 NC_008769.1 cell division protein ftsY 3188183 ftsY 4698243 ftsY Mycobacterium bovis BCG str. Pasteur 1173P2 cell division protein ftsY YP_979026.1 3186915 R 410289 CDS YP_979027.1 121638803 4698534 complement(3188233..3191850) 1 NC_008769.1 Differs from Rv2922c by 2aa, R364L, G698R; chromosome partition protein smc 3191850 smc 4698534 smc Mycobacterium bovis BCG str. Pasteur 1173P2 chromosome partition protein smc YP_979027.1 3188233 R 410289 CDS YP_979028.1 121638804 4697291 complement(3191862..3192143) 1 NC_008769.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 3192143 acyP 4697291 acyP Mycobacterium bovis BCG str. Pasteur 1173P2 acylphosphatase YP_979028.1 3191862 R 410289 CDS YP_979029.1 121638805 4697487 complement(3192130..3192543) 1 NC_008769.1 hypothetical protein 3192543 4697487 BCG_2945c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979029.1 3192130 R 410289 CDS YP_979030.1 121638806 4698820 complement(3192645..3193514) 1 NC_008769.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 3193514 fpg 4698820 fpg Mycobacterium bovis BCG str. Pasteur 1173P2 formamidopyrimidine-DNA glycosylase YP_979030.1 3192645 R 410289 CDS YP_979031.1 121638807 4695630 complement(3193818..3194540) 1 NC_008769.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 3194540 rnc 4695630 rnc Mycobacterium bovis BCG str. Pasteur 1173P2 ribonuclease III YP_979031.1 3193818 R 410289 CDS YP_979032.1 121638808 4697606 complement(3194537..3195160) 1 NC_008769.1 hypothetical protein 3195160 4697606 BCG_2948c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979032.1 3194537 R 410289 CDS YP_979033.1 121638809 4698455 complement(3195211..3195948) 1 NC_008769.1 hypothetical protein 3195948 4698455 BCG_2949c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979033.1 3195211 R 410289 CDS YP_979034.1 121638810 4698552 3196187..3196972 1 NC_008769.1 thioesterase tesA 3196972 tesA 4698552 tesA Mycobacterium bovis BCG str. Pasteur 1173P2 thioesterase tesA YP_979034.1 3196187 D 410289 CDS YP_979035.1 121638811 4696849 3196959..3197270 1 NC_008769.1 hypothetical protein 3197270 4696849 BCG_2951 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979035.1 3196959 D 410289 CDS YP_979036.1 121638812 4699366 3197686..3199437 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3199437 fadD26 4699366 fadD26 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_979036.1 3197686 D 410289 CDS YP_979037.1 121638813 4696810 3199434..3205064 1 NC_008769.1 Differs from Rv2931 at several positions; phenolpthiocerol synthesis type-I polyketide synthase ppsA 3205064 ppsA 4696810 ppsA Mycobacterium bovis BCG str. Pasteur 1173P2 phenolpthiocerol synthesis type-I polyketide synthase ppsA YP_979037.1 3199434 D 410289 CDS YP_979038.1 121638814 4696369 3205061..3209677 1 NC_008769.1 Differs from Mb2957 and Rv2932 at several positions; phenolpthiocerol synthesis type-I polyketide synthase ppsB 3209677 ppsB 4696369 ppsB Mycobacterium bovis BCG str. Pasteur 1173P2 phenolpthiocerol synthesis type-I polyketide synthase ppsB YP_979038.1 3205061 D 410289 CDS YP_979039.1 121638815 4696370 3209674..3216240 1 NC_008769.1 phenolpthiocerol synthesis type-I polyketide synthase ppsC 3216240 ppsC 4696370 ppsC Mycobacterium bovis BCG str. Pasteur 1173P2 phenolpthiocerol synthesis type-I polyketide synthase ppsC YP_979039.1 3209674 D 410289 CDS YP_979040.1 121638816 4696371 3216237..3221720 1 NC_008769.1 Differs from Rv2934 at several positions; phenolpthiocerol synthesis type-I polyketide synthase ppsD 3221720 ppsD 4696371 ppsD Mycobacterium bovis BCG str. Pasteur 1173P2 phenolpthiocerol synthesis type-I polyketide synthase ppsD YP_979040.1 3216237 D 410289 CDS YP_979041.1 121638817 4696372 3221726..3226192 1 NC_008769.1 Differs from Rv2935 at several positions; phenolpthiocerol synthesis type-I polyketide synthase ppsE 3226192 ppsE 4696372 ppsE Mycobacterium bovis BCG str. Pasteur 1173P2 phenolpthiocerol synthesis type-I polyketide synthase ppsE YP_979041.1 3221726 D 410289 CDS YP_979042.1 121638818 4696488 3226203..3227198 1 NC_008769.1 Differs from Rv2936 by 1aa, D309H; daunorubicin-DIM-transport ATP-binding protein ABC transporter drrA 3227198 drrA 4696488 drrA Mycobacterium bovis BCG str. Pasteur 1173P2 daunorubicin-DIM-transport ATP-binding protein ABC transporter drrA YP_979042.1 3226203 D 410289 CDS YP_979043.1 121638819 4697913 3227195..3228064 1 NC_008769.1 daunorubicin-DIM-transport integral membrane protein ABC transporter drrB 3228064 drrB 4697913 drrB Mycobacterium bovis BCG str. Pasteur 1173P2 daunorubicin-DIM-transport integral membrane protein ABC transporter drrB YP_979043.1 3227195 D 410289 CDS YP_979044.1 121638820 4695804 3228061..3228891 1 NC_008769.1 daunorubicin-DIM-transport integral membrane protein ABC transporter drrC 3228891 drrC 4695804 drrC Mycobacterium bovis BCG str. Pasteur 1173P2 daunorubicin-DIM-transport integral membrane protein ABC transporter drrC YP_979044.1 3228061 D 410289 CDS YP_979045.1 121638821 4698462 3228938..3230206 1 NC_008769.1 required for PDIM synthesis; phthiocerol and phthiodiolone dimycocerosate esters are scaffolds used for virulence-enhancing lipids; proposed to catalyze diesterification of phthiocerol and phthiodolone with mycocerosate; functions in polyketide synthesis; acyltransferase 3230206 papA5 4698462 papA5 Mycobacterium bovis BCG str. Pasteur 1173P2 acyltransferase YP_979045.1 3228938 D 410289 CDS YP_979046.1 121638822 4697547 complement(3230369..3236704) 1 NC_008769.1 multifunctional mycocerosic acid synthase membrane-associated mas 3236704 mas 4697547 mas Mycobacterium bovis BCG str. Pasteur 1173P2 multifunctional mycocerosic acid synthase membrane-associated mas YP_979046.1 3230369 R 410289 CDS YP_979047.1 121638823 4698663 3237324..3239066 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3239066 fadD28 4698663 fadD28 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_979047.1 3237324 D 410289 CDS YP_979048.1 121638824 4697440 3239059..3241821 1 NC_008769.1 transmembrane transport protein mmpL7 3241821 mmpL7 4697440 mmpL7 Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane transport protein mmpL7 YP_979048.1 3239059 D 410289 CDS YP_979049.1 121638825 4696173 3242453..3243694 1 NC_008769.1 transposase for insertion sequence element IS1533 3243694 4696173 BCG_2965 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase for insertion sequence element IS1533 YP_979049.1 3242453 D 410289 CDS YP_979050.1 121638826 4699139 3243694..3244224 1 NC_008769.1 transposase 3244224 4699139 BCG_2966 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979050.1 3243694 D 410289 CDS YP_979051.1 121638827 4698622 complement(3244613..3245314) 1 NC_008769.1 lipoprotein lppX 3245314 lppX 4698622 lppX Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppX YP_979051.1 3244613 R 410289 CDS YP_979052.1 121638828 4698613 complement(3245663..3252001) 1 NC_008769.1 In Mycobacterium tuberculosis H37Rv, pks1 and pks15 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-g) results in a single product that is more similar to pks1. Differs from Rv2946c by 2aa, G1779V, V1859A, and from Rv2947c by 2aa, A333V, R374G; polyketide synthase pks1 3252001 pks1 4698613 pks1 Mycobacterium bovis BCG str. Pasteur 1173P2 polyketide synthase pks1 YP_979052.1 3245663 R 410289 CDS YP_979053.1 121638829 4696189 complement(3251998..3254115) 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3254115 fadD22 4696189 fadD22 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_979053.1 3251998 R 410289 CDS YP_979054.1 121638830 4697263 complement(3254132..3254731) 1 NC_008769.1 hypothetical protein 3254731 4697263 BCG_2970c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979054.1 3254132 R 410289 CDS YP_979055.1 121638831 4699144 complement(3254757..3256616) 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3256616 fadD29 4699144 fadD29 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_979055.1 3254757 R 410289 CDS YP_979056.1 121638832 4698078 complement(3257264..3258409) 1 NC_008769.1 oxidoreductase 3258409 4698078 BCG_2972c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979056.1 3257264 R 410289 CDS YP_979057.1 121638833 4698612 3258602..3259414 1 NC_008769.1 methyltransferase 3259414 4698612 BCG_2973 Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase YP_979057.1 3258602 D 410289 CDS YP_979058.1 121638834 4698602 3259440..3260696 1 NC_008769.1 hypothetical protein 3260696 4698602 BCG_2974 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979058.1 3259440 D 410289 CDS YP_979059.1 121638835 4698582 complement(3260827..3261552) 1 NC_008769.1 Differs from Rv2954c and Mb2978c by 1aa, Q194R; hypothetical protein 3261552 4698582 BCG_2975c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979059.1 3260827 R 410289 CDS YP_979060.1 121638836 4698501 complement(3261741..3262706) 1 NC_008769.1 Differs from Rv2955c by 1aa, H27R; hypothetical protein 3262706 4698501 BCG_2976c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979060.1 3261741 R 410289 CDS YP_979061.1 121638837 4699372 3262829..3263560 1 NC_008769.1 Differs from Rv2956 by 1aa, T237I; hypothetical protein 3263560 4699372 BCG_2977 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979061.1 3262829 D 410289 CDS YP_979062.1 121638838 4699132 3263631..3264458 1 NC_008769.1 glycosyl transferase family protein 3264458 4699132 BCG_2978 Mycobacterium bovis BCG str. Pasteur 1173P2 glycosyl transferase family protein YP_979062.1 3263631 D 410289 CDS YP_979063.1 121638839 4699360 complement(3265062..3266162) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; glycosyl transferase family protein 3266162 4699360 BCG_2979c Mycobacterium bovis BCG str. Pasteur 1173P2 glycosyl transferase family protein YP_979063.1 3265062 R 410289 CDS YP_979064.1 121638840 4699276 complement(3266263..3267000) 1 NC_008769.1 methyltransferase 3267000 4699276 BCG_2980c Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase YP_979064.1 3266263 R 410289 CDS YP_979065.1 121638841 4698451 complement(3267115..3267363) 1 NC_008769.1 hypothetical protein 3267363 4698451 BCG_2981c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979065.1 3267115 R 410289 CDS YP_979066.1 121638842 4699036 3267445..3267834 1 NC_008769.1 transposase 3267834 4699036 BCG_2982 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979066.1 3267445 D 410289 CDS YP_979067.1 121638843 4698528 complement(3267935..3269284) 1 NC_008769.1 glycosyl transferase family protein 3269284 4698528 BCG_2983c Mycobacterium bovis BCG str. Pasteur 1173P2 glycosyl transferase family protein YP_979067.1 3267935 R 410289 CDS YP_979068.1 121638844 4699354 3269398..3270618 1 NC_008769.1 integral membrane protein 3270618 4699354 BCG_2984 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_979068.1 3269398 D 410289 CDS YP_979069.1 121638845 4697912 3270691..3271623 1 NC_008769.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 3271623 purU 4697912 purU Mycobacterium bovis BCG str. Pasteur 1173P2 formyltetrahydrofolate deformylase YP_979069.1 3270691 D 410289 CDS YP_979070.1 121638846 4696060 complement(3272492..3272977) 1 NC_008769.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 3272977 coaD 4696060 coaD Mycobacterium bovis BCG str. Pasteur 1173P2 phosphopantetheine adenylyltransferase YP_979070.1 3272492 R 410289 CDS YP_979071.1 121638847 4696454 complement(3273063..3273629) 1 NC_008769.1 methyltransferase 3273629 4696454 BCG_2987c Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase YP_979071.1 3273063 R 410289 CDS YP_979072.1 121638848 4698328 complement(3273825..3277208) 1 NC_008769.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate; pyruvate carboxylase 3277208 pca 4698328 pca Mycobacterium bovis BCG str. Pasteur 1173P2 pyruvate carboxylase YP_979072.1 3273825 R 410289 CDS YP_979073.1 121638849 4698835 complement(3277233..3277865) 1 NC_008769.1 integral membrane protein 3277865 4698835 BCG_2989c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_979073.1 3277233 R 410289 CDS YP_979074.1 121638850 4696395 complement(3277871..3278638) 1 NC_008769.1 membrane or hypothetical protein 3278638 4696395 BCG_2990c Mycobacterium bovis BCG str. Pasteur 1173P2 membrane or hypothetical protein YP_979074.1 3277871 R 410289 CDS YP_979075.1 121638851 4698333 complement(3278735..3279865) 1 NC_008769.1 lipase/esterase lipN 3279865 lipN 4698333 lipN Mycobacterium bovis BCG str. Pasteur 1173P2 lipase/esterase lipN YP_979075.1 3278735 R 410289 CDS YP_979076.1 121638852 4698635 3280096..3280266 1 NC_008769.1 hypothetical protein 3280266 4698635 BCG_2992 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979076.1 3280096 D 410289 CDS YP_979077.1 121638853 4698228 3280263..3281111 1 NC_008769.1 Differs from Rv2971 by 1aa, H152N; oxidoreductase 3281111 4698228 BCG_2993 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979077.1 3280263 D 410289 CDS YP_979078.1 121638854 4698611 complement(3281185..3281898) 1 NC_008769.1 hypothetical protein 3281898 4698611 BCG_2994c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979078.1 3281185 R 410289 CDS YP_979079.1 121638855 4698230 complement(3281895..3284108) 1 NC_008769.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 3284108 recG 4698230 recG Mycobacterium bovis BCG str. Pasteur 1173P2 ATP-dependent DNA helicase RecG YP_979079.1 3281895 R 410289 CDS YP_979080.1 121638856 4695838 complement(3284111..3285772) 1 NC_008769.1 In Mycobacterium tuberculosis H37Rv, Rv2975c and Rv2974c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 2 bp deletion (cg-*) results in a single product that is more similar to Rv2974c; hypothetical protein 3285772 4695838 BCG_2996c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979080.1 3284111 R 410289 CDS YP_979081.1 121638857 4698022 complement(3286231..3286914) 1 NC_008769.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 3286914 ung 4698022 ung Mycobacterium bovis BCG str. Pasteur 1173P2 uracil-DNA glycosylase YP_979081.1 3286231 R 410289 CDS YP_979082.1 121638858 4696501 complement(3286947..3287948) 1 NC_008769.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 3287948 thiL 4696501 thiL Mycobacterium bovis BCG str. Pasteur 1173P2 thiamine monophosphate kinase YP_979082.1 3286947 R 410289 CDS YP_979083.1 121638859 4695453 complement(3287945..3289324) 1 NC_008769.1 transposase 3289324 4695453 BCG_2999c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979083.1 3287945 R 410289 CDS YP_979084.1 121638860 4699361 complement(3289324..3289908) 1 NC_008769.1 Differs from Rv2979c by 3aa, R14P, A79T, G151D; resolvase 3289908 4699361 BCG_3000c Mycobacterium bovis BCG str. Pasteur 1173P2 resolvase YP_979084.1 3289324 R 410289 CDS YP_979085.1 121638861 4698293 3290120..3290665 1 NC_008769.1 hypothetical protein 3290665 4698293 BCG_3001 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979085.1 3290120 D 410289 CDS YP_979086.1 121638862 4698165 complement(3291310..3292431) 1 NC_008769.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 3292431 ddl 4698165 ddl Mycobacterium bovis BCG str. Pasteur 1173P2 D-alanyl-alanine synthetase A YP_979086.1 3291310 R 410289 CDS YP_979087.1 121638863 4697648 complement(3292509..3293513) 1 NC_008769.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 3293513 gpsA 4697648 gpsA Mycobacterium bovis BCG str. Pasteur 1173P2 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_979087.1 3292509 R 410289 CDS YP_979088.1 121638864 4697625 3293632..3294276 1 NC_008769.1 hypothetical protein 3294276 4697625 BCG_3004 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979088.1 3293632 D 410289 CDS YP_979089.1 121638865 4699068 3294368..3296596 1 NC_008769.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 3296596 ppk 4699068 ppk Mycobacterium bovis BCG str. Pasteur 1173P2 polyphosphate kinase YP_979089.1 3294368 D 410289 CDS YP_979090.1 121638866 4698102 3296679..3297632 1 NC_008769.1 hydrolase mutT1 3297632 mutT1 4698102 mutT1 Mycobacterium bovis BCG str. Pasteur 1173P2 hydrolase mutT1 YP_979090.1 3296679 D 410289 CDS YP_979091.1 121638867 4697973 complement(3297690..3298307) 1 NC_008769.1 Differs from Rv2986c and Mb3010c by 9aa deletion at position 137; DNA-binding protein HU hupB 3298307 hupB 4697973 hupB Mycobacterium bovis BCG str. Pasteur 1173P2 DNA-binding protein HU hupB YP_979091.1 3297690 R 410289 CDS YP_979092.1 121638868 4697264 complement(3298520..3299116) 1 NC_008769.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 3299116 leuD 4697264 leuD Mycobacterium bovis BCG str. Pasteur 1173P2 isopropylmalate isomerase small subunit YP_979092.1 3298520 R 410289 CDS YP_979093.1 121638869 4697484 complement(3299141..3300562) 1 NC_008769.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 3300562 leuC 4697484 leuC Mycobacterium bovis BCG str. Pasteur 1173P2 isopropylmalate isomerase large subunit YP_979093.1 3299141 R 410289 CDS YP_979094.1 121638870 4697483 3300634..3301335 1 NC_008769.1 transcriptional regulatory protein 3301335 4697483 BCG_3010 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_979094.1 3300634 D 410289 CDS YP_979095.1 121638871 4698651 complement(3301346..3302206) 1 NC_008769.1 Differs from Mb3014c by 1aa, A217E; hypothetical protein 3302206 4698651 BCG_3011c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979095.1 3301346 R 410289 CDS YP_979096.1 121638872 4698376 3302469..3302960 1 NC_008769.1 Differs from Rv2991 by 1aa, T93A; hypothetical protein 3302960 4698376 BCG_3012 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979096.1 3302469 D 410289 CDS YP_979097.1 121638873 4696853 complement(3303292..3304764) 1 NC_008769.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 3304764 gltX 4696853 gltX Mycobacterium bovis BCG str. Pasteur 1173P2 glutamyl-tRNA synthetase YP_979097.1 3303292 R 410289 CDS YP_979098.1 121638874 4697845 complement(3304761..3305480) 1 NC_008769.1 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase 3305480 4697845 BCG_3014c Mycobacterium bovis BCG str. Pasteur 1173P2 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase YP_979098.1 3304761 R 410289 CDS YP_979099.1 121638875 4699349 3305756..3307093 1 NC_008769.1 integral membrane protein 3307093 4699349 BCG_3015 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_979099.1 3305756 D 410289 CDS YP_979100.1 121638876 4698609 complement(3306945..3307955) 1 NC_008769.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 3307955 leuB 4698609 leuB Mycobacterium bovis BCG str. Pasteur 1173P2 3-isopropylmalate dehydrogenase YP_979100.1 3306945 R 410289 CDS YP_979101.1 121638877 4697482 complement(3307970..3309556) 1 NC_008769.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 3309556 serA1 4697482 serA1 Mycobacterium bovis BCG str. Pasteur 1173P2 D-3-phosphoglycerate dehydrogenase YP_979101.1 3307970 R 410289 CDS YP_979102.1 121638878 4697883 3309586..3311028 1 NC_008769.1 Differs from Rv2997 by 1aa S108C; alanine rich dehydrogenase 3311028 4697883 BCG_3018 Mycobacterium bovis BCG str. Pasteur 1173P2 alanine rich dehydrogenase YP_979102.1 3309586 D 410289 CDS YP_979103.1 121638879 4698173 3311302..3311763 1 NC_008769.1 hypothetical protein 3311763 4698173 BCG_3019 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979103.1 3311302 D 410289 CDS YP_979104.1 121638880 4699381 complement(3311712..3311915) 1 NC_008769.1 hypothetical protein 3311915 4699381 BCG_3020c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979104.1 3311712 R 410289 CDS YP_979105.1 121638881 4699367 3312089..3313054 1 NC_008769.1 Differs from Rv2999 by 1aa, L212M; lipoprotein lppY 3313054 lppY 4699367 lppY Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppY YP_979105.1 3312089 D 410289 CDS YP_979106.1 121638882 4698614 3313099..3313758 1 NC_008769.1 hypothetical protein 3313758 4698614 BCG_3022 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979106.1 3313099 D 410289 CDS YP_979107.1 121638883 4698160 complement(3314072..3315073) 1 NC_008769.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 3315073 ilvC 4698160 ilvC Mycobacterium bovis BCG str. Pasteur 1173P2 ketol-acid reductoisomerase YP_979107.1 3314072 R 410289 CDS YP_979108.1 121638884 4699340 complement(3315111..3315617) 1 NC_008769.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 3315617 ilvH 4699340 ilvH Mycobacterium bovis BCG str. Pasteur 1173P2 acetolactate synthase 3 regulatory subunit YP_979108.1 3315111 R 410289 CDS YP_979109.1 121638885 4698974 complement(3315617..3317473) 1 NC_008769.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 1 catalytic subunit 3317473 ilvB1 4698974 ilvB1 Mycobacterium bovis BCG str. Pasteur 1173P2 acetolactate synthase 1 catalytic subunit YP_979109.1 3315617 R 410289 CDS YP_979110.1 121638886 4699338 3317835..3318173 1 NC_008769.1 low molecular weight protein antigen 6 cfp6 3318173 cfp6 4699338 cfp6 Mycobacterium bovis BCG str. Pasteur 1173P2 low molecular weight protein antigen 6 cfp6 YP_979110.1 3317835 D 410289 CDS YP_979111.1 121638887 4697041 complement(3318180..3319019) 1 NC_008769.1 hypothetical protein 3319019 4697041 BCG_3027c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979111.1 3318180 R 410289 CDS YP_979112.1 121638888 4698897 3319196..3320317 1 NC_008769.1 Differs from Rv3006 by 1aa, D219G; lipoprotein lppZ 3320317 lppZ 4698897 lppZ Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppZ YP_979112.1 3319196 D 410289 CDS YP_979113.1 121638889 4698615 complement(3320323..3320937) 1 NC_008769.1 oxidoreductase 3320937 4698615 BCG_3029c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979113.1 3320323 R 410289 CDS YP_979114.1 121638890 4698277 3321131..3321754 1 NC_008769.1 hypothetical protein 3321754 4698277 BCG_3030 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979114.1 3321131 D 410289 CDS YP_979115.1 121638891 4699219 complement(3321751..3323280) 1 NC_008769.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 3323280 gatB 4699219 gatB Mycobacterium bovis BCG str. Pasteur 1173P2 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_979115.1 3321751 R 410289 CDS YP_979116.1 121638892 4695748 complement(3323310..3324341) 1 NC_008769.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 3324341 pfkA 4695748 pfkA Mycobacterium bovis BCG str. Pasteur 1173P2 6-phosphofructokinase YP_979116.1 3323310 R 410289 CDS YP_979117.1 121638893 4698542 complement(3324437..3325921) 1 NC_008769.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 3325921 gatA 4698542 gatA Mycobacterium bovis BCG str. Pasteur 1173P2 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_979117.1 3324437 R 410289 CDS YP_979118.1 121638894 4695747 complement(3325918..3326217) 1 NC_008769.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 3326217 gatC 4695747 gatC Mycobacterium bovis BCG str. Pasteur 1173P2 aspartyl/glutamyl-tRNA amidotransferase subunit C YP_979118.1 3325918 R 410289 CDS YP_979119.1 121638895 4695749 3326302..3326958 1 NC_008769.1 hypothetical protein 3326958 4695749 BCG_3035 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979119.1 3326302 D 410289 CDS YP_979120.1 121638896 4698197 complement(3327032..3329107) 1 NC_008769.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 3329107 ligA 4698197 ligA Mycobacterium bovis BCG str. Pasteur 1173P2 NAD-dependent DNA ligase LigA YP_979120.1 3327032 R 410289 CDS YP_979121.1 121638897 4697272 complement(3329138..3330151) 1 NC_008769.1 hypothetical protein 3330151 4697272 BCG_3037c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979121.1 3329138 R 410289 CDS YP_979122.1 121638898 4698339 3330245..3330874 1 NC_008769.1 lipoprotein lpqA 3330874 lpqA 4698339 lpqA Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqA YP_979122.1 3330245 D 410289 CDS YP_979123.1 121638899 4698616 complement(3330977..3331339) 1 NC_008769.1 ESAT-6 like protein 8 esxQ 3331339 esxQ 4698616 esxQ Mycobacterium bovis BCG str. Pasteur 1173P2 ESAT-6 like protein 8 esxQ YP_979123.1 3330977 R 410289 CDS YP_979124.1 121638900 4697503 complement(3331426..3332739) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 56 bp deletion leads to a product slightly different at the Nh2-terminus part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (434 aa versus 437 aa). Differs from Rv3018c by 1aa, A53V, and Mb3043c by 1aa, L328V; PPE family protein 3332739 PPE46 4697503 PPE46 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979124.1 3331426 R 410289 CDS YP_979126.1 121638902 4697128 complement(3333142..3333432) 1 NC_008769.1 ESAT-6 like protein 9 esxR 3333432 esxR 4697128 esxR Mycobacterium bovis BCG str. Pasteur 1173P2 ESAT-6 like protein 9 esxR YP_979126.1 3333142 R 410289 CDS YP_979127.1 121638903 4696143 complement(3333467..3333760) 1 NC_008769.1 PE family protein 3333760 esxS 4696143 esxS Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_979127.1 3333467 R 410289 CDS YP_979128.1 121638904 4696291 complement(3333807..3335114) 1 NC_008769.1 In Mycobacterium Mycobacterium tuberculosis H37Rv, PPE47 and PPE48 exist as 2 separate genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-g) leads to a single product; PPE family protein 3335114 PPE47 4696291 PPE47 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979128.1 3333807 R 410289 CDS YP_979129.1 121638905 4696407 complement(3335111..3335425) 1 NC_008769.1 PE family protein 3335425 PE29 4696407 PE29 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_979129.1 3335111 R 410289 CDS YP_979130.1 121638906 4697129 complement(3335807..3337054) 1 NC_008769.1 Differs from Rv3023c by 1aa T9A; transposase 3337054 4697129 BCG_3046c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979130.1 3335807 R 410289 CDS YP_979131.1 121638907 4698236 complement(3337217..3338320) 1 NC_008769.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 3338320 mnmA 4698236 mnmA Mycobacterium bovis BCG str. Pasteur 1173P2 tRNA-specific 2-thiouridylase MnmA YP_979131.1 3337217 R 410289 CDS YP_979132.1 121638908 4697330 complement(3338317..3339498) 1 NC_008769.1 cysteine desulfurase iscS 3339498 iscS 4697330 iscS Mycobacterium bovis BCG str. Pasteur 1173P2 cysteine desulfurase iscS YP_979132.1 3338317 R 410289 CDS YP_979133.1 121638909 4697434 complement(3339595..3340509) 1 NC_008769.1 hypothetical protein 3340509 4697434 BCG_3049c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979133.1 3339595 R 410289 CDS YP_979134.1 121638910 4698512 complement(3340506..3341246) 1 NC_008769.1 hypothetical protein 3341246 4698512 BCG_3050c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979134.1 3340506 R 410289 CDS YP_979135.1 121638911 4696482 complement(3341507..3342463) 1 NC_008769.1 Differs from Rv3028c by 1aa, V312A; electron transfer flavoprotein (alpha-subunit) fixB 3342463 fixB 4696482 fixB Mycobacterium bovis BCG str. Pasteur 1173P2 electron transfer flavoprotein (alpha-subunit) fixB YP_979135.1 3341507 R 410289 CDS YP_979136.1 121638912 4695797 complement(3342502..3343302) 1 NC_008769.1 electron transfer flavoprotein (beta-subunit) fixA 3343302 fixA 4695797 fixA Mycobacterium bovis BCG str. Pasteur 1173P2 electron transfer flavoprotein (beta-subunit) fixA YP_979136.1 3342502 R 410289 CDS YP_979137.1 121638913 4695796 3343533..3344357 1 NC_008769.1 hypothetical protein 3344357 4695796 BCG_3053 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979137.1 3343533 D 410289 CDS YP_979138.1 121638914 4697615 3344354..3345934 1 NC_008769.1 hypothetical protein 3345934 4697615 BCG_3054 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979138.1 3344354 D 410289 CDS YP_979139.1 121638915 4698985 3345966..3347210 1 NC_008769.1 Differs from Rv3032 and Mb3058 by 1aa, P380Q; transferase 3347210 4698985 BCG_3055 Mycobacterium bovis BCG str. Pasteur 1173P2 transferase YP_979139.1 3345966 D 410289 CDS YP_979140.1 121638916 4696061 3347244..3347633 1 NC_008769.1 hypothetical protein 3347633 4696061 BCG_3056 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979140.1 3347244 D 410289 CDS YP_979141.1 121638917 4699087 3347812..3348360 1 NC_008769.1 hypothetical protein 3348360 4699087 BCG_3057 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979141.1 3347812 D 410289 CDS YP_979142.1 121638918 4698604 complement(3348451..3349353) 1 NC_008769.1 transferase 3349353 4698604 BCG_3058c Mycobacterium bovis BCG str. Pasteur 1173P2 transferase YP_979142.1 3348451 R 410289 CDS YP_979143.1 121638919 4695705 3349811..3350893 1 NC_008769.1 hypothetical protein 3350893 4695705 BCG_3059 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979143.1 3349811 D 410289 CDS YP_979144.1 121638920 4698149 complement(3350890..3351573) 1 NC_008769.1 Differs from Mb3062c by 1aa, Q63R; hypothetical protein 3351573 TB22.2 4698149 TB22.2 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979144.1 3350890 R 410289 CDS YP_979145.1 121638921 4697563 complement(3351646..3352722) 1 NC_008769.1 Differs from Rv3037c by 1aa, A7D; hypothetical protein 3352722 4697563 BCG_3061c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979145.1 3351646 R 410289 CDS YP_979146.1 121638922 4699369 complement(3352857..3353840) 1 NC_008769.1 hypothetical protein 3353840 4699369 BCG_3062c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979146.1 3352857 R 410289 CDS YP_979147.1 121638923 4699010 complement(3353851..3354615) 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 3354615 echA17 4699010 echA17 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_979147.1 3353851 R 410289 CDS YP_979148.1 121638924 4695778 complement(3354624..3355490) 1 NC_008769.1 hypothetical protein 3355490 4695778 BCG_3064c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979148.1 3354624 R 410289 CDS YP_979149.1 121638925 4698104 complement(3355487..3356350) 1 NC_008769.1 ABC transporter ATP-binding protein 3356350 4698104 BCG_3065c Mycobacterium bovis BCG str. Pasteur 1173P2 ABC transporter ATP-binding protein YP_979149.1 3355487 R 410289 CDS YP_979150.1 121638926 4699373 complement(3356365..3357594) 1 NC_008769.1 Differs from Rv3042c by 2aa, S70A, E116G; phosphoserine phosphatase serB2 3357594 serB2 4699373 serB2 Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoserine phosphatase serB2 YP_979150.1 3356365 R 410289 CDS YP_979151.1 121638927 4696250 complement(3357632..3359353) 1 NC_008769.1 cytochrome C oxidase polypeptide I ctaD 3359353 ctaD 4696250 ctaD Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome C oxidase polypeptide I ctaD YP_979151.1 3357632 R 410289 CDS YP_979152.1 121638928 4698123 3359568..3360647 1 NC_008769.1 FeIII-dicitrate-binding periplasmic lipoprotein fecB 3360647 fecB 4698123 fecB Mycobacterium bovis BCG str. Pasteur 1173P2 FeIII-dicitrate-binding periplasmic lipoprotein fecB YP_979152.1 3359568 D 410289 CDS YP_979153.1 121638929 4695363 3360717..3361757 1 NC_008769.1 NADP-dependent alcohol dehydrogenase adhC 3361757 adhC 4695363 adhC Mycobacterium bovis BCG str. Pasteur 1173P2 NADP-dependent alcohol dehydrogenase adhC YP_979153.1 3360717 D 410289 CDS YP_979154.1 121638930 4696512 complement(3361746..3362120) 1 NC_008769.1 hypothetical protein 3362120 4696512 BCG_3070c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979154.1 3361746 R 410289 CDS YP_979155.1 121638931 4697966 complement(3362454..3362738) 1 NC_008769.1 hypothetical protein 3362738 4697966 BCG_3071c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979155.1 3362454 R 410289 CDS YP_979156.1 121638932 4696111 complement(3362836..3363810) 1 NC_008769.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 3363810 nrdF 4696111 nrdF Mycobacterium bovis BCG str. Pasteur 1173P2 ribonucleotide-diphosphate reductase subunit beta YP_979156.1 3362836 R 410289 CDS YP_979157.1 121638933 4698715 complement(3363941..3365515) 1 NC_008769.1 monooxygenase 3365515 4698715 BCG_3073c Mycobacterium bovis BCG str. Pasteur 1173P2 monooxygenase YP_979157.1 3363941 R 410289 CDS YP_979158.1 121638934 4698105 complement(3365649..3366389) 1 NC_008769.1 AsnC family transcriptional regulator 3366389 4698105 BCG_3074c Mycobacterium bovis BCG str. Pasteur 1173P2 AsnC family transcriptional regulator YP_979158.1 3365649 R 410289 CDS YP_979159.1 121638935 4697914 complement(3366517..3368598) 1 NC_008769.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 3368598 nrdE 4697914 nrdE Mycobacterium bovis BCG str. Pasteur 1173P2 ribonucleotide-diphosphate reductase subunit alpha YP_979159.1 3366517 R 410289 CDS YP_979160.1 121638936 4698714 complement(3368664..3369116) 1 NC_008769.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 3369116 nrdI 4698714 nrdI Mycobacterium bovis BCG str. Pasteur 1173P2 ribonucleotide reductase stimulatory protein YP_979160.1 3368664 R 410289 CDS YP_979161.1 121638937 4698717 complement(3369151..3369390) 1 NC_008769.1 glutaredoxin electron transport component of nrdEF (glutaredoxin-like protein) nrdH 3369390 nrdH 4698717 nrdH Mycobacterium bovis BCG str. Pasteur 1173P2 glutaredoxin electron transport component of nrdEF (glutaredoxin-like protein) nrdH YP_979161.1 3369151 R 410289 CDS YP_979162.1 121638938 4698716 complement(3369368..3369736) 1 NC_008769.1 hypothetical protein 3369736 4698716 BCG_3078c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979162.1 3369368 R 410289 CDS YP_979163.1 121638939 4697903 complement(3369853..3370407) 1 NC_008769.1 hypothetical protein 3370407 4697903 BCG_3079c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979163.1 3369853 R 410289 CDS YP_979164.1 121638940 4697980 3370499..3371113 1 NC_008769.1 TetR family transcriptional regulator 3371113 4697980 BCG_3080 Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_979164.1 3370499 D 410289 CDS YP_979165.1 121638941 4697981 3371123..3372163 1 NC_008769.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 3372163 dinP 4697981 dinP Mycobacterium bovis BCG str. Pasteur 1173P2 DNA polymerase IV YP_979165.1 3371123 D 410289 CDS YP_979166.1 121638942 4696052 complement(3372217..3373080) 1 NC_008769.1 short chain dehydrogenase 3373080 4696052 BCG_3082c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_979166.1 3372217 R 410289 CDS YP_979167.1 121638943 4698077 complement(3373144..3373794) 1 NC_008769.1 TetR family transcriptional regulator 3373794 4698077 BCG_3083c Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_979167.1 3373144 R 410289 CDS YP_979168.1 121638944 4697976 3373910..3375388 1 NC_008769.1 Differs from Mb3085 by 1aa, E44K and Rv3059 by 2aa, E44K, G445D; cytochrome P450 136 cyp136 3375388 cyp136 4697976 cyp136 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome P450 136 cyp136 YP_979168.1 3373910 D 410289 CDS YP_979169.1 121638945 4698529 complement(3376159..3377631) 1 NC_008769.1 GntR family transcriptional regulator 3377631 4698529 BCG_3085c Mycobacterium bovis BCG str. Pasteur 1173P2 GntR family transcriptional regulator YP_979169.1 3376159 R 410289 CDS YP_979170.1 121638946 4697991 complement(3377748..3379913) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium tuberculosis strain H37Rv, fadE22 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits fadE22 into 2 parts, fadE22a and fadE22b. Differs from Mb3087c and from Rv3061c by 2aa, E488K, C497S; acyl-CoA dehydrogenase fadE22 3379913 fadE22 4697991 fadE22 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE22 YP_979170.1 3377748 R 410289 CDS YP_979171.1 121638947 4699121 3380070..3381593 1 NC_008769.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; ATP-dependent DNA ligase 3381593 ligB 4699121 ligB Mycobacterium bovis BCG str. Pasteur 1173P2 ATP-dependent DNA ligase YP_979171.1 3380070 D 410289 CDS YP_979172.1 121638948 4697273 3381729..3384005 1 NC_008769.1 Differs from Rv3063 by 3aa, C402G, S559R, P600L; carbon starvation protein A cstA 3384005 cstA 4697273 cstA Mycobacterium bovis BCG str. Pasteur 1173P2 carbon starvation protein A cstA YP_979172.1 3381729 D 410289 CDS YP_979173.1 121638949 4697932 complement(3384311..3384736) 1 NC_008769.1 integral membrane protein 3384736 4697932 BCG_3089c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_979173.1 3384311 R 410289 CDS YP_979174.1 121638950 4697994 3384873..3385196 1 NC_008769.1 multidrugs-transport integral membrane protein mmr 3385196 mmr 4697994 mmr Mycobacterium bovis BCG str. Pasteur 1173P2 multidrugs-transport integral membrane protein mmr YP_979174.1 3384873 D 410289 CDS YP_979175.1 121638951 4697599 3385193..3385801 1 NC_008769.1 DeoR family transcriptional regulator 3385801 4697599 BCG_3091 Mycobacterium bovis BCG str. Pasteur 1173P2 DeoR family transcriptional regulator YP_979175.1 3385193 D 410289 CDS YP_979176.1 121638952 4697982 3385914..3386324 1 NC_008769.1 Differs from Rv3067 and Mb3094 by 1aa A3T; hypothetical protein 3386324 4697982 BCG_3092 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979176.1 3385914 D 410289 CDS YP_979177.1 121638953 4697080 complement(3386465..3388108) 1 NC_008769.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 3388108 pgmA 4697080 pgmA Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoglucomutase YP_979177.1 3386465 R 410289 CDS YP_979178.1 121638954 4698855 3388178..3388576 1 NC_008769.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 3388576 4698855 BCG_3094 Mycobacterium bovis BCG str. Pasteur 1173P2 camphor resistance protein CrcB YP_979178.1 3388178 D 410289 CDS YP_979179.1 121638955 4697995 3388573..3388953 1 NC_008769.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 3388953 4697995 BCG_3095 Mycobacterium bovis BCG str. Pasteur 1173P2 camphor resistance protein CrcB YP_979179.1 3388573 D 410289 CDS YP_979180.1 121638956 4696534 3388950..3390059 1 NC_008769.1 hypothetical protein 3390059 4696534 BCG_3096 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979180.1 3388950 D 410289 CDS YP_979181.1 121638957 4698777 complement(3390284..3390808) 1 NC_008769.1 hypothetical protein 3390808 4698777 BCG_3097c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979181.1 3390284 R 410289 CDS YP_979182.1 121638958 4696731 complement(3390815..3391171) 1 NC_008769.1 hypothetical protein 3391171 4696731 BCG_3098c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979182.1 3390815 R 410289 CDS YP_979183.1 121638959 4698058 3391265..3392539 1 NC_008769.1 hypothetical protein 3392539 4698058 BCG_3099 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979183.1 3391265 D 410289 CDS YP_979184.1 121638960 4698912 complement(3392536..3393459) 1 NC_008769.1 hypothetical protein 3393459 4698912 BCG_3100c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979184.1 3392536 R 410289 CDS YP_979185.1 121638961 4698732 3393558..3394034 1 NC_008769.1 hypothetical protein 3394034 4698732 BCG_3101 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979185.1 3393558 D 410289 CDS YP_979186.1 121638962 4698690 3394027..3395838 1 NC_008769.1 Differs from Rv3077 by 1aa R311G; hydrolase 3395838 4698690 BCG_3102 Mycobacterium bovis BCG str. Pasteur 1173P2 hydrolase YP_979186.1 3394027 D 410289 CDS YP_979187.1 121638963 4698718 3395839..3396240 1 NC_008769.1 hydroxylaminobenzene mutase hab 3396240 hab 4698718 hab Mycobacterium bovis BCG str. Pasteur 1173P2 hydroxylaminobenzene mutase hab YP_979187.1 3395839 D 410289 CDS YP_979188.1 121638964 4695479 complement(3396256..3397083) 1 NC_008769.1 hypothetical protein 3397083 4695479 BCG_3104c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979188.1 3396256 R 410289 CDS YP_979189.1 121638965 4698735 complement(3397142..3400474) 1 NC_008769.1 Differs from Rv3080c by 1aa, V217A; serine/threonine-protein kinase transcriptional regulatory protein pknK 3400474 pknK 4698735 pknK Mycobacterium bovis BCG str. Pasteur 1173P2 serine/threonine-protein kinase transcriptional regulatory protein pknK YP_979189.1 3397142 R 410289 CDS YP_979190.1 121638966 4697526 3400526..3401764 1 NC_008769.1 Differs from Rv3081 and Mb3108 by 1aa, A108V; hypothetical protein 3401764 4697526 BCG_3106 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979190.1 3400526 D 410289 CDS YP_979191.1 121638967 4698733 complement(3401890..3402912) 1 NC_008769.1 Differs from Rv3082c by 1aa, C322R; virulence-regulating transcriptional regulator VirS 3402912 virS 4698733 virS Mycobacterium bovis BCG str. Pasteur 1173P2 virulence-regulating transcriptional regulator VirS YP_979191.1 3401890 R 410289 CDS YP_979192.1 121638968 4697232 3402990..3404477 1 NC_008769.1 Differs from Mb3110 by 1aa, S81I and from Rv3083 by 2aa, S81I, I94V; monooxygenase 3404477 4697232 BCG_3108 Mycobacterium bovis BCG str. Pasteur 1173P2 monooxygenase YP_979192.1 3402990 D 410289 CDS YP_979193.1 121638969 4698744 3404483..3405409 1 NC_008769.1 Differs from Rv3084 and Mb3111 by 1aa, G276S; acetyl-hydrolase/esterase lipR 3405409 lipR 4698744 lipR Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-hydrolase/esterase lipR YP_979193.1 3404483 D 410289 CDS YP_979194.1 121638970 4696904 3405406..3406236 1 NC_008769.1 short-chain type dehydrogenase/reductase 3406236 4696904 BCG_3110 Mycobacterium bovis BCG str. Pasteur 1173P2 short-chain type dehydrogenase/reductase YP_979194.1 3405406 D 410289 CDS YP_979195.1 121638971 4698740 3406267..3407373 1 NC_008769.1 zinc-type alcohol dehydrogenase adhD 3407373 adhD 4698740 adhD Mycobacterium bovis BCG str. Pasteur 1173P2 zinc-type alcohol dehydrogenase adhD YP_979195.1 3406267 D 410289 CDS YP_979196.1 121638972 4695601 3407411..3408829 1 NC_008769.1 Differs from Rv3087 by 1aa, V447L, and from Mb3114 by 1aa, T158A; hypothetical protein 3408829 4695601 BCG_3112 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979196.1 3407411 D 410289 CDS YP_979197.1 121638973 4698742 3408826..3410250 1 NC_008769.1 hypothetical protein 3410250 4698742 BCG_3113 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979197.1 3408826 D 410289 CDS YP_979198.1 121638974 4698712 3410247..3411758 1 NC_008769.1 chain-fatty-acid-CoA ligase fadD13 3411758 fadD13 4698712 fadD13 Mycobacterium bovis BCG str. Pasteur 1173P2 chain-fatty-acid-CoA ligase fadD13 YP_979198.1 3410247 D 410289 CDS YP_979199.1 121638975 4695381 3412697..3413584 1 NC_008769.1 hypothetical protein 3413584 4695381 BCG_3115 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979199.1 3412697 D 410289 CDS YP_979200.1 121638976 4698728 3413602..3415293 1 NC_008769.1 hypothetical protein 3415293 4698728 BCG_3116 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979200.1 3413602 D 410289 CDS YP_979201.1 121638977 4698739 complement(3415300..3416220) 1 NC_008769.1 Differs from Mb3119c by 1 aa, I237M; integral membrane protein 3416220 4698739 BCG_3117c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_979201.1 3415300 R 410289 CDS YP_979202.1 121638978 4698734 complement(3416246..3417250) 1 NC_008769.1 Differs from Rv3093c by 1aa W210C; oxidoreductase 3417250 4698734 BCG_3118c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979202.1 3416246 R 410289 CDS YP_979203.1 121638979 4698731 complement(3417247..3418377) 1 NC_008769.1 hypothetical protein 3418377 4698731 BCG_3119c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979203.1 3417247 R 410289 CDS YP_979204.1 121638980 4698753 3418459..3418935 1 NC_008769.1 transcriptional regulator 3418935 4698753 BCG_3120 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulator YP_979204.1 3418459 D 410289 CDS YP_979205.1 121638981 4698736 3419033..3420172 1 NC_008769.1 Differs from Rv3097 by 1aa G28E; hypothetical protein 3420172 4698736 BCG_3121 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979205.1 3419033 D 410289 CDS YP_979206.1 121638982 4698748 complement(3420264..3421577) 1 NC_008769.1 Differs from Rv3097c by 1aa A58G; hypothetical protein 3421577 PE_PGRS63 4698748 PE_PGRS63 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979206.1 3420264 R 410289 CDS YP_979207.1 121638983 4699255 complement(3421696..3422148) 1 NC_008769.1 Differs from Rv3098c by 1aa E117D; hypothetical protein 3422148 4699255 BCG_3123c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979207.1 3421696 R 410289 CDS YP_979208.1 121638984 4698655 complement(3422899..3423750) 1 NC_008769.1 hypothetical protein 3423750 4698655 BCG_3124c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979208.1 3422899 R 410289 CDS YP_979209.1 121638985 4698752 complement(3423787..3424269) 1 NC_008769.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 3424269 smpB 4698752 smpB Mycobacterium bovis BCG str. Pasteur 1173P2 SsrA-binding protein YP_979209.1 3423787 R 410289 CDS YP_979210.1 121638986 4697292 complement(3424272..3425165) 1 NC_008769.1 Differs from Rv3101c by 1aa, S171N; cell division protein ftsX 3425165 ftsX 4697292 ftsX Mycobacterium bovis BCG str. Pasteur 1173P2 cell division protein ftsX YP_979210.1 3424272 R 410289 CDS YP_979211.1 121638987 4698533 complement(3425166..3425855) 1 NC_008769.1 cell division ATP-binding protein ftsE 3425855 ftsE 4698533 ftsE Mycobacterium bovis BCG str. Pasteur 1173P2 cell division ATP-binding protein ftsE YP_979211.1 3425166 R 410289 CDS YP_979212.1 121638988 4695821 complement(3425899..3426336) 1 NC_008769.1 hypothetical protein 3426336 4695821 BCG_3128c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979212.1 3425899 R 410289 CDS YP_979213.1 121638989 4698108 complement(3426338..3427264) 1 NC_008769.1 hypothetical protein 3427264 4698108 BCG_3129c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979213.1 3426338 R 410289 CDS YP_979214.1 121638990 4698722 complement(3427254..3428390) 1 NC_008769.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 3428390 prfB 4698722 prfB Mycobacterium bovis BCG str. Pasteur 1173P2 peptide chain release factor 2 YP_979214.1 3427254 R 410289 CDS YP_979215.1 121638991 4697853 3428494..3429864 1 NC_008769.1 Differs from Rv3106 by 2aa, I141V, D385N; NADPH:adrenodoxin oxidoreductase fprA 3429864 fprA 4697853 fprA Mycobacterium bovis BCG str. Pasteur 1173P2 NADPH:adrenodoxin oxidoreductase fprA YP_979215.1 3428494 D 410289 CDS YP_979216.1 121638992 4697655 complement(3429865..3431448) 1 NC_008769.1 alkyldihydroxyacetonephosphate synthase agpS 3431448 agpS 4697655 agpS Mycobacterium bovis BCG str. Pasteur 1173P2 alkyldihydroxyacetonephosphate synthase agpS YP_979216.1 3429865 R 410289 CDS YP_979217.1 121638993 4695494 3431547..3431987 1 NC_008769.1 Differs from Mb3135 by 1aa I145V; hypothetical protein 3431987 4695494 BCG_3133 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979217.1 3431547 D 410289 CDS YP_979218.1 121638994 4698745 3432136..3433215 1 NC_008769.1 Differs from Mb3136 by 1aa, T324A; molybdenum cofactor biosynthesis protein A moaA1 3433215 moaA1 4698745 moaA1 Mycobacterium bovis BCG str. Pasteur 1173P2 molybdenum cofactor biosynthesis protein A moaA1 YP_979218.1 3432136 D 410289 CDS YP_979219.1 121638995 4698506 3433266..3433661 1 NC_008769.1 pterin-4-alpha-carbinolamine dehydratase moaB1 3433661 moaB1 4698506 moaB1 Mycobacterium bovis BCG str. Pasteur 1173P2 pterin-4-alpha-carbinolamine dehydratase moaB1 YP_979219.1 3433266 D 410289 CDS YP_979220.1 121638996 4695602 3433658..3434170 1 NC_008769.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 3434170 moaC 4695602 moaC Mycobacterium bovis BCG str. Pasteur 1173P2 molybdenum cofactor biosynthesis protein MoaC YP_979220.1 3433658 D 410289 CDS YP_979221.1 121638997 4695605 3434187..3434438 1 NC_008769.1 molybdenum cofactor biosynthesis protein MoaD 3434438 moaD1 4695605 moaD1 Mycobacterium bovis BCG str. Pasteur 1173P2 molybdenum cofactor biosynthesis protein MoaD YP_979221.1 3434187 D 410289 CDS YP_979222.1 121638998 4698494 3434560..3435228 1 NC_008769.1 Differs from Rv3113 by 3aa, C11W, E134G, R191L; phosphatase 3435228 4698494 BCG_3138 Mycobacterium bovis BCG str. Pasteur 1173P2 phosphatase YP_979222.1 3434560 D 410289 CDS YP_979223.1 121638999 4698759 3435245..3435775 1 NC_008769.1 Differs from Rv3114 by 1aa, P11S; hypothetical protein 3435775 4698759 BCG_3139 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979223.1 3435245 D 410289 CDS YP_979224.1 121639000 4698761 3435937..3437184 1 NC_008769.1 transposase 3437184 4698761 BCG_3140 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979224.1 3435937 D 410289 CDS YP_979225.1 121639001 4698766 3437262..3438431 1 NC_008769.1 molybdenum cofactor biosynthesis protein moeB2 3438431 moeB2 4698766 moeB2 Mycobacterium bovis BCG str. Pasteur 1173P2 molybdenum cofactor biosynthesis protein moeB2 YP_979225.1 3437262 D 410289 CDS YP_979226.1 121639002 4697173 3438460..3439422 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a large deletion of 2775 bp (RD12) leads to the loss of the COOH part of cysA3, the following CDSs, sseC1, moaE1, Rv3120 and a large part of cyp141 except the COOH end, compared to the homolog in Mycobacterium tuberculosis strain H37Rv; thiosulfate sulfurtransferase cysA3 3439422 cysA3 4697173 cysA3 Mycobacterium bovis BCG str. Pasteur 1173P2 thiosulfate sulfurtransferase cysA3 YP_979226.1 3438460 D 410289 CDS YP_979227.1 121639003 4696712 3439800..3440270 1 NC_008769.1 Differs from Rv3122 by 1aa, S156R; hypothetical protein 3440270 4696712 BCG_3143 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979227.1 3439800 D 410289 CDS YP_979228.1 121639004 4698750 3440280..3440774 1 NC_008769.1 Differs from Rv3123 by 1aa, Q40R; hypothetical protein 3440774 4698750 BCG_3144 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979228.1 3440280 D 410289 CDS YP_979229.1 121639005 4698767 3441217..3442086 1 NC_008769.1 Differs from Rv3124 and Mb3147 by 1aa, G159E; transcriptional regulatory protein 3442086 4698767 BCG_3145 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_979229.1 3441217 D 410289 CDS YP_979230.1 121639006 4698773 complement(3442187..3442501) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, PPE49 has incurred a single base deletion in codon 272 compared to Rv3125c and Mb3148c leading to frameshift, and two products of 282 and 104 aa, compared to 391 in others; PPE family protein 3442501 PPE49b 4698773 PPE49b Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979230.1 3442187 R 410289 CDS YP_979231.1 121639007 4696409 complement(3442513..3443361) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, PPE49 has incurred a single base deletion in codon 272 compared to Rv3125c and Mb3148c leading to frameshift, and two products of 282 and 104 aa, compared to 391 in others. Differs from Rv3125c by 1aa, V38A; PPE family protein 3443361 PPE49a 4696409 PPE49a Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979231.1 3442513 R 410289 CDS YP_979232.1 121639008 4696408 complement(3443518..3443832) 1 NC_008769.1 hypothetical protein 3443832 4696408 BCG_3148c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979232.1 3443518 R 410289 CDS YP_979233.1 121639009 4698751 3443857..3444891 1 NC_008769.1 Differs from Rv3127 by 1aa, C95F; hypothetical protein 3444891 4698751 BCG_3149 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979233.1 3443857 D 410289 CDS YP_979234.1 121639010 4698772 complement(3444878..3445228) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv3128c exists as a single gene with an in-frame amber stop codon. In Mycobacterium bovis, Rv3128c is split into 2, Mb3151c and Mb3152c; hypothetical protein 3445228 4698772 BCG_3150c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979234.1 3444878 R 410289 CDS YP_979235.1 121639011 4698770 complement(3445310..3445891) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv3128c exists as a single gene with an in-frame amber stop codon. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, Rv3128c is split into 2 genes; Differs from Mb3152c by 1aa, V166G; hypothetical protein 3445891 4698770 BCG_3151c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979235.1 3445310 R 410289 CDS YP_979236.1 121639012 4698783 3446370..3446702 1 NC_008769.1 hypothetical protein 3446702 4698783 BCG_3152 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979236.1 3446370 D 410289 CDS YP_979237.1 121639013 4698774 complement(3446685..3448076) 1 NC_008769.1 hypothetical protein 3448076 4698774 BCG_3153c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979237.1 3446685 R 410289 CDS YP_979238.1 121639014 4698776 3448261..3449259 1 NC_008769.1 hypothetical protein 3449259 4698776 BCG_3154 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979238.1 3448261 D 410289 CDS YP_979239.1 121639015 4698764 complement(3449239..3450975) 1 NC_008769.1 Differs from Rv3132c by 1aa, T283I; two component sensor histidine kinase devS 3450975 devS 4698764 devS Mycobacterium bovis BCG str. Pasteur 1173P2 two component sensor histidine kinase devS YP_979239.1 3449239 R 410289 CDS YP_979240.1 121639016 4696781 complement(3450972..3451625) 1 NC_008769.1 two component transcriptional regulatory protein DevR 3451625 devR 4696781 devR Mycobacterium bovis BCG str. Pasteur 1173P2 two component transcriptional regulatory protein DevR YP_979240.1 3450972 R 410289 CDS YP_979241.1 121639017 4698170 complement(3451653..3452459) 1 NC_008769.1 hypothetical protein 3452459 4698170 BCG_3157c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979241.1 3451653 R 410289 CDS YP_979242.1 121639018 4698789 3453044..3454189 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a large 1337 bp insertion (I-RD08) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (381 aa versus 132 aa). Differs from Mb3159 by 1aa, K213E; PPE family protein 3454189 PPE50 4698789 PPE50 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979242.1 3453044 D 410289 CDS YP_979243.1 121639019 4696877 3454841..3455983 1 NC_008769.1 PPE family protein 3455983 PPE51 4696877 PPE51 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979243.1 3454841 D 410289 CDS YP_979244.1 121639020 4696878 3456440..3457222 1 NC_008769.1 Differs from Rv3137 by 1aa, L168P; monophosphatase 3457222 4696878 BCG_3160 Mycobacterium bovis BCG str. Pasteur 1173P2 monophosphatase YP_979244.1 3456440 D 410289 CDS YP_979245.1 121639021 4698804 3457242..3458330 1 NC_008769.1 Differs from Rv3138 by 2aa, N110S, P271T, and from Mb3162 by 2aa, F257S, P270L; pyruvate formate lyase activating protein pflA 3458330 pflA 4698804 pflA Mycobacterium bovis BCG str. Pasteur 1173P2 pyruvate formate lyase activating protein pflA YP_979245.1 3457242 D 410289 CDS YP_979246.1 121639022 4698544 3458410..3459816 1 NC_008769.1 acyl-CoA dehydrogenase fadE24 3459816 fadE24 4698544 fadE24 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE24 YP_979246.1 3458410 D 410289 CDS YP_979247.1 121639023 4697412 3459837..3461042 1 NC_008769.1 acyl-CoA dehydrogenase fadE23 3461042 fadE23 4697412 fadE23 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE23 YP_979247.1 3459837 D 410289 CDS YP_979248.1 121639024 4697411 3461142..3462113 1 NC_008769.1 NADPH quinone oxidoreductase fadB4 3462113 fadB4 4697411 fadB4 Mycobacterium bovis BCG str. Pasteur 1173P2 NADPH quinone oxidoreductase fadB4 YP_979248.1 3461142 D 410289 CDS YP_979249.1 121639025 4697223 complement(3462165..3462593) 1 NC_008769.1 Differs from Mb3166c by 1aa, H133Q; hypothetical protein 3462593 4697223 BCG_3165c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979249.1 3462165 R 410289 CDS YP_979250.1 121639026 4698640 3462701..3463102 1 NC_008769.1 response regulator 3463102 4698640 BCG_3166 Mycobacterium bovis BCG str. Pasteur 1173P2 response regulator YP_979250.1 3462701 D 410289 CDS YP_979251.1 121639027 4697904 complement(3463135..3464364) 1 NC_008769.1 Differs from Rv3144c by 1aa, G226S; PPE family protein 3464364 PPE52 4697904 PPE52 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979251.1 3463135 R 410289 CDS YP_979252.1 121639028 4696879 3464729..3465115 1 NC_008769.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 3465115 nuoA 4696879 nuoA Mycobacterium bovis BCG str. Pasteur 1173P2 NADH dehydrogenase subunit A YP_979252.1 3464729 D 410289 CDS YP_979253.1 121639029 4699186 3465124..3465678 1 NC_008769.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 3465678 nuoB 4699186 nuoB Mycobacterium bovis BCG str. Pasteur 1173P2 NADH dehydrogenase subunit B YP_979253.1 3465124 D 410289 CDS YP_979254.1 121639030 4696399 3465675..3466385 1 NC_008769.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit C 3466385 nuoC 4696399 nuoC Mycobacterium bovis BCG str. Pasteur 1173P2 NADH dehydrogenase subunit C YP_979254.1 3465675 D 410289 CDS YP_979255.1 121639031 4696400 3466385..3467707 1 NC_008769.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 3467707 nuoD 4696400 nuoD Mycobacterium bovis BCG str. Pasteur 1173P2 NADH dehydrogenase subunit D YP_979255.1 3466385 D 410289 CDS YP_979256.1 121639032 4696401 3467704..3468462 1 NC_008769.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 3468462 nuoE 4696401 nuoE Mycobacterium bovis BCG str. Pasteur 1173P2 NADH dehydrogenase subunit E YP_979256.1 3467704 D 410289 CDS YP_979257.1 121639033 4696402 3468459..3469796 1 NC_008769.1 NADH dehydrogenase I subunit F 3469796 nuoF 4696402 nuoF Mycobacterium bovis BCG str. Pasteur 1173P2 NADH dehydrogenase I subunit F YP_979257.1 3468459 D 410289 CDS YP_979258.1 121639034 4696403 3469793..3472213 1 NC_008769.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 3472213 nuoG 4696403 nuoG Mycobacterium bovis BCG str. Pasteur 1173P2 NADH dehydrogenase subunit G YP_979258.1 3469793 D 410289 CDS YP_979259.1 121639035 4696594 3472329..3473561 1 NC_008769.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 3473561 nuoH 4696594 nuoH Mycobacterium bovis BCG str. Pasteur 1173P2 NADH dehydrogenase subunit H YP_979259.1 3472329 D 410289 CDS YP_979260.1 121639036 4696595 3473554..3474189 1 NC_008769.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 3474189 nuoI 4696595 nuoI Mycobacterium bovis BCG str. Pasteur 1173P2 NADH dehydrogenase subunit I YP_979260.1 3473554 D 410289 CDS YP_979261.1 121639037 4696596 3474186..3474974 1 NC_008769.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 3474974 nuoJ 4696596 nuoJ Mycobacterium bovis BCG str. Pasteur 1173P2 NADH dehydrogenase subunit J YP_979261.1 3474186 D 410289 CDS YP_979262.1 121639038 4696597 3474971..3475270 1 NC_008769.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 3475270 nuoK 4696597 nuoK Mycobacterium bovis BCG str. Pasteur 1173P2 NADH dehydrogenase subunit K YP_979262.1 3474971 D 410289 CDS YP_979263.1 121639039 4696598 3475281..3477182 1 NC_008769.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 3477182 nuoL 4696598 nuoL Mycobacterium bovis BCG str. Pasteur 1173P2 NADH dehydrogenase subunit L YP_979263.1 3475281 D 410289 CDS YP_979264.1 121639040 4697202 3477179..3478840 1 NC_008769.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 3478840 nuoM 4697202 nuoM Mycobacterium bovis BCG str. Pasteur 1173P2 NADH dehydrogenase subunit M YP_979264.1 3477179 D 410289 CDS YP_979265.1 121639041 4697203 3478837..3480432 1 NC_008769.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 3480432 nuoN 4697203 nuoN Mycobacterium bovis BCG str. Pasteur 1173P2 NADH dehydrogenase subunit N YP_979265.1 3478837 D 410289 CDS YP_979266.1 121639042 4697204 complement(3480438..3482207) 1 NC_008769.1 In Mycobacterium bovis BCG pasteur and Mycobacterium bovis, albeit a 2146 bp insertion occurs overlapping the NH2-terminal part, this leads to an equivalent product, compared to its homolog in Mycobacterium tuberculosis strain H37Rv; Differs from Rv3159c by 2aa, deletion of A64, V87A, and from Mb3183c by 1aa, V87A; PPE family protein 3482207 PPE53 4697204 PPE53 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979266.1 3480438 R 410289 CDS YP_979267.1 121639043 4696880 complement(3482455..3484356) 1 NC_008769.1 In Mycobacterium bovis BCG pasteur and Mycobacterium bovis, an insertion of 2146 bp exists between PPE53 and Rv3160c compared to Mycobacterium tuberculosis strain H37Rv. This leads to an additional gene, PPE70 equivalent to MT3248 from Mycobacterium tuberculosis strain CDC1551. Differs from Mb3184c by 1aa, deletion of A64; PPE family protein 3484356 PPE70 4696880 PPE70 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979267.1 3482455 R 410289 CDS YP_979268.1 121639044 4696415 complement(3484531..3485172) 1 NC_008769.1 TetR family transcriptional regulator 3485172 4696415 BCG_3184c Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_979268.1 3484531 R 410289 CDS YP_979269.1 121639045 4698756 complement(3485183..3486331) 1 NC_008769.1 Differs from Rv3161c by 1aa, L62V; dioxygenase 3486331 4698756 BCG_3185c Mycobacterium bovis BCG str. Pasteur 1173P2 dioxygenase YP_979269.1 3485183 R 410289 CDS YP_979270.1 121639046 4698799 complement(3486247..3486837) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (t-*), leads to a longer product with different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; integral membrane protein 3486837 4698799 BCG_3186c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_979270.1 3486247 R 410289 CDS YP_979271.1 121639047 4698801 complement(3486834..3488105) 1 NC_008769.1 Differs from Mb3188c by 1aa, D341E; hypothetical protein 3488105 4698801 BCG_3187c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979271.1 3486834 R 410289 CDS YP_979272.1 121639048 4698795 complement(3488135..3489097) 1 NC_008769.1 Differs from Mb3189c by 1aa, E20G; methanol dehydrogenase transcriptional regulatory protein moxR3 3489097 moxR3 4698795 moxR3 Mycobacterium bovis BCG str. Pasteur 1173P2 methanol dehydrogenase transcriptional regulatory protein moxR3 YP_979272.1 3488135 R 410289 CDS YP_979273.1 121639049 4698910 complement(3489105..3489587) 1 NC_008769.1 hypothetical protein 3489587 4698910 BCG_3189c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979273.1 3489105 R 410289 CDS YP_979274.1 121639050 4698787 complement(3489584..3490543) 1 NC_008769.1 Differs from Rv3166c and Mb3191c by 1aa, A202S; hypothetical protein 3490543 4698787 BCG_3190c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979274.1 3489584 R 410289 CDS YP_979275.1 121639051 4698797 complement(3490623..3491249) 1 NC_008769.1 TetR family transcriptional regulator 3491249 4698797 BCG_3191c Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_979275.1 3490623 R 410289 CDS YP_979276.1 121639052 4698813 3491294..3492430 1 NC_008769.1 Differs from Mb3193 by 1aa, W65R; hypothetical protein 3492430 4698813 BCG_3192 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979276.1 3491294 D 410289 CDS YP_979277.1 121639053 4698150 3492430..3493554 1 NC_008769.1 hypothetical protein 3493554 4698150 BCG_3193 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979277.1 3492430 D 410289 CDS YP_979278.1 121639054 4698807 3493697..3495043 1 NC_008769.1 flavin-containing monoamine oxidase AofH 3495043 aofH 4698807 aofH Mycobacterium bovis BCG str. Pasteur 1173P2 flavin-containing monoamine oxidase AofH YP_979278.1 3493697 D 410289 CDS YP_979279.1 121639055 4696663 complement(3495038..3495937) 1 NC_008769.1 Differs from Rv3171c by 1aa, M201T; non-heme haloperoxidase hpx 3495937 hpx 4696663 hpx Mycobacterium bovis BCG str. Pasteur 1173P2 non-heme haloperoxidase hpx YP_979279.1 3495038 R 410289 CDS YP_979280.1 121639056 4696103 complement(3496074..3496556) 1 NC_008769.1 hypothetical protein 3496556 4696103 BCG_3196c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979280.1 3496074 R 410289 CDS YP_979281.1 121639057 4698828 complement(3496635..3497237) 1 NC_008769.1 TetR family transcriptional regulator 3497237 4698828 BCG_3197c Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_979281.1 3496635 R 410289 CDS YP_979282.1 121639058 4698821 3497330..3498037 1 NC_008769.1 Differs from Rv3174 by 1aa, A9V; short chain dehydrogenase 3498037 4698821 BCG_3198 Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_979282.1 3497330 D 410289 CDS YP_979283.1 121639059 4698822 3498052..3499539 1 NC_008769.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 3499539 4698822 BCG_3199 Mycobacterium bovis BCG str. Pasteur 1173P2 amidase YP_979283.1 3498052 D 410289 CDS YP_979284.1 121639060 4697905 complement(3499536..3499853) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mesT into 2 parts, mesTa and mesTb; epoxide hydrolase mesTb 3499853 mesTb 4697905 mesTb Mycobacterium bovis BCG str. Pasteur 1173P2 epoxide hydrolase mesTb YP_979284.1 3499536 R 410289 CDS YP_979285.1 121639061 4698207 complement(3499865..3500491) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mesT into 2 parts, mesTa and mesTb; epoxide hydrolase mesTa 3500491 mesTa 4698207 mesTa Mycobacterium bovis BCG str. Pasteur 1173P2 epoxide hydrolase mesTa YP_979285.1 3499865 R 410289 CDS YP_979286.1 121639062 4696116 3500638..3501498 1 NC_008769.1 peroxidase 3501498 4696116 BCG_3202 Mycobacterium bovis BCG str. Pasteur 1173P2 peroxidase YP_979286.1 3500638 D 410289 CDS YP_979287.1 121639063 4698826 3501629..3501988 1 NC_008769.1 hypothetical protein 3501988 4698826 BCG_3203 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979287.1 3501629 D 410289 CDS YP_979288.1 121639064 4698816 3502228..3502521 1 NC_008769.1 hypothetical protein 3502521 4698816 BCG_3204 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979288.1 3502228 D 410289 CDS YP_979289.1 121639065 4698824 3502809..3504098 1 NC_008769.1 hypothetical protein 3504098 4698824 BCG_3205 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979289.1 3502809 D 410289 CDS YP_979290.1 121639066 4698845 complement(3504445..3504879) 1 NC_008769.1 hypothetical protein 3504879 4698845 BCG_3206c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979290.1 3504445 R 410289 CDS YP_979291.1 121639067 4698866 complement(3504882..3505334) 1 NC_008769.1 hypothetical protein 3505334 4698866 BCG_3207c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979291.1 3504882 R 410289 CDS YP_979292.1 121639068 4698838 3505565..3505909 1 NC_008769.1 hypothetical protein 3505909 4698838 BCG_3208 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979292.1 3505565 D 410289 CDS YP_979293.1 121639069 4698868 3505906..3506235 1 NC_008769.1 transcriptional regulatory protein 3506235 4698868 BCG_3209 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_979293.1 3505906 D 410289 CDS YP_979294.1 121639070 4698113 3506773..3507120 1 NC_008769.1 hypothetical protein 3507120 4698113 BCG_3210 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979294.1 3506773 D 410289 CDS YP_979295.1 121639071 4698872 3507117..3507737 1 NC_008769.1 hypothetical protein 3507737 4698872 BCG_3211 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979295.1 3507117 D 410289 CDS YP_979296.1 121639072 4698832 complement(3507897..3509162) 1 NC_008769.1 Differs from Rv3190c by 2aa, P138L, A330V; hypothetical protein 3509162 4698832 BCG_3212c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979296.1 3507897 R 410289 CDS YP_979297.1 121639073 4698886 complement(3509786..3510820) 1 NC_008769.1 transposase 3510820 4698886 BCG_3213c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979297.1 3509786 R 410289 CDS YP_979298.1 121639074 4697285 3512035..3512496 1 NC_008769.1 hypothetical protein 3512496 4697285 BCG_3214 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979298.1 3512035 D 410289 CDS YP_979299.1 121639075 4698885 complement(3512666..3515644) 1 NC_008769.1 Differs from Rv3193c by 2aa, E356Q, Q843R, and from Mb3215c by 1aa, E356Q; hypothetical protein 3515644 4698885 BCG_3215c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979299.1 3512666 R 410289 CDS YP_979300.1 121639076 4698877 complement(3515736..3516758) 1 NC_008769.1 hypothetical protein 3516758 4698877 BCG_3216c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979300.1 3515736 R 410289 CDS YP_979301.1 121639077 4698913 3516836..3518254 1 NC_008769.1 hypothetical protein 3518254 4698913 BCG_3217 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979301.1 3516836 D 410289 CDS YP_979302.1 121639078 4698914 3518260..3519159 1 NC_008769.1 hypothetical protein 3519159 4698914 BCG_3218 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979302.1 3518260 D 410289 CDS YP_979303.1 121639079 4698880 complement(3519168..3519368) 1 NC_008769.1 hypothetical protein 3519368 4698880 BCG_3219c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979303.1 3519168 R 410289 CDS YP_979304.1 121639080 4698780 3519506..3520849 1 NC_008769.1 ABC transporter ATP-binding protein 3520849 4698780 BCG_3220 Mycobacterium bovis BCG str. Pasteur 1173P2 ABC transporter ATP-binding protein YP_979304.1 3519506 D 410289 CDS YP_979305.1 121639081 4699274 complement(3520883..3521161) 1 NC_008769.1 transcriptional regulatory protein whiB-like whiB7 3521161 whiB7 4699274 whiB7 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein whiB-like whiB7 YP_979305.1 3520883 R 410289 CDS YP_979306.1 121639082 4697346 complement(3521591..3523693) 1 NC_008769.1 DNA helicase II 3523693 UvrD2 4697346 UvrD2 Mycobacterium bovis BCG str. Pasteur 1173P2 DNA helicase II YP_979306.1 3521591 R 410289 CDS YP_979307.1 121639083 4697230 3523817..3524071 1 NC_008769.1 glutaredoxin protein 3524071 4697230 BCG_3223 Mycobacterium bovis BCG str. Pasteur 1173P2 glutaredoxin protein YP_979307.1 3523817 D 410289 CDS YP_979308.1 121639084 4698241 complement(3524084..3525025) 1 NC_008769.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 3525025 nudC 4698241 nudC Mycobacterium bovis BCG str. Pasteur 1173P2 NADH pyrophosphatase YP_979308.1 3524084 R 410289 CDS YP_979309.1 121639085 4699185 complement(3525084..3526151) 1 NC_008769.1 Differs from Rv3200c by 1aa, D12N; transmembrane cation transporter 3526151 4699185 BCG_3225c Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane cation transporter YP_979309.1 3525084 R 410289 CDS YP_979310.1 121639086 4698860 complement(3526213..3529518) 1 NC_008769.1 ATP-dependent DNA helicase 3529518 4698860 BCG_3226c Mycobacterium bovis BCG str. Pasteur 1173P2 ATP-dependent DNA helicase YP_979310.1 3526213 R 410289 CDS YP_979311.1 121639087 4698870 complement(3529515..3532682) 1 NC_008769.1 Differs from Rv3202c by 1aa, A748V; ATP-dependent DNA helicase 3532682 4698870 BCG_3227c Mycobacterium bovis BCG str. Pasteur 1173P2 ATP-dependent DNA helicase YP_979311.1 3529515 R 410289 CDS YP_979312.1 121639088 4698831 3532759..3532977 1 NC_008769.1 hypothetical protein 3532977 4698831 BCG_3228 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979312.1 3532759 D 410289 CDS YP_979313.1 121639089 4699043 3533119..3533793 1 NC_008769.1 lipase lipV 3533793 lipV 4699043 lipV Mycobacterium bovis BCG str. Pasteur 1173P2 lipase lipV YP_979313.1 3533119 D 410289 CDS YP_979314.1 121639090 4695783 3533796..3534101 1 NC_008769.1 Differs from Rv3204 by 1aa, A34T; DNA-methyltransferase 3534101 4695783 BCG_3230 Mycobacterium bovis BCG str. Pasteur 1173P2 DNA-methyltransferase YP_979314.1 3533796 D 410289 CDS YP_979315.1 121639091 4699356 complement(3534108..3534986) 1 NC_008769.1 hypothetical protein 3534986 4699356 BCG_3231c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979315.1 3534108 R 410289 CDS YP_979316.1 121639092 4699322 complement(3535013..3536191) 1 NC_008769.1 The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; molybdopterin biosynthesis-like protein MoeZ 3536191 moeB1 4699322 moeB1 Mycobacterium bovis BCG str. Pasteur 1173P2 molybdopterin biosynthesis-like protein MoeZ YP_979316.1 3535013 R 410289 CDS YP_979317.1 121639093 4697172 complement(3536282..3537139) 1 NC_008769.1 Differs from Rv3207c by 1aa, N157D; hypothetical protein 3537139 4697172 BCG_3233c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979317.1 3536282 R 410289 CDS YP_979318.1 121639094 4698942 3537485..3538171 1 NC_008769.1 TetR family transcriptional regulator 3538171 4698942 BCG_3234 Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_979318.1 3537485 D 410289 CDS YP_979319.1 121639095 4699128 complement(3538158..3538430) 1 NC_008769.1 hypothetical protein 3538430 TB9.4 4699128 TB9.4 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979319.1 3538158 R 410289 CDS YP_979320.1 121639096 4696847 3538755..3539315 1 NC_008769.1 hypothetical protein 3539315 4696847 BCG_3236 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979320.1 3538755 D 410289 CDS YP_979321.1 121639097 4699020 complement(3539325..3540020) 1 NC_008769.1 hypothetical protein 3540020 4699020 BCG_3237c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979321.1 3539325 R 410289 CDS YP_979322.1 121639098 4698996 3540279..3541862 1 NC_008769.1 Differs from Mb3237 by 1aa, V17A; ATP-dependent RNA helicase rhlE 3541862 rhlE 4698996 rhlE Mycobacterium bovis BCG str. Pasteur 1173P2 ATP-dependent RNA helicase rhlE YP_979322.1 3540279 D 410289 CDS YP_979323.1 121639099 4696799 3541875..3543098 1 NC_008769.1 Differs from Mb3238 by 1aa, G225D, and from Rv3212 by 2aa, G225D, A250V; hypothetical protein 3543098 4696799 BCG_3239 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979323.1 3541875 D 410289 CDS YP_979324.1 121639100 4698246 complement(3543174..3543974) 1 NC_008769.1 Differs from Rv3213c by 1aa, E144K; soj/parA-related protein 3543974 4698246 BCG_3240c Mycobacterium bovis BCG str. Pasteur 1173P2 soj/parA-related protein YP_979324.1 3543174 R 410289 CDS YP_979325.1 121639101 4698231 3544128..3544739 1 NC_008769.1 forms a homodimer in Mycobacterium tuberculosis; belongs to the dPGM superfamily; acid phosphatase 3544739 gpm2_1 4698231 gpm2_1 Mycobacterium bovis BCG str. Pasteur 1173P2 acid phosphatase YP_979325.1 3544128 D 410289 CDS YP_979326.1 121639102 4697841 3544736..3545854 1 NC_008769.1 isochorismate synthase entC 3545854 entC_1 4697841 entC_1 Mycobacterium bovis BCG str. Pasteur 1173P2 isochorismate synthase entC YP_979326.1 3544736 D 410289 CDS YP_979327.1 121639103 4697924 3546002..3546334 1 NC_008769.1 acetyltransferase 3546334 4697924 BCG_3243 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyltransferase YP_979327.1 3546002 D 410289 CDS YP_979328.1 121639104 4698887 complement(3546286..3546717) 1 NC_008769.1 integral membrane protein 3546717 4698887 BCG_3244c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_979328.1 3546286 R 410289 CDS YP_979329.1 121639105 4698247 3546950..3547915 1 NC_008769.1 hypothetical protein 3547915 4698247 BCG_3245 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979329.1 3546950 D 410289 CDS YP_979330.1 121639106 4698039 3548195..3548449 1 NC_008769.1 transcriptional regulatory protein whiB-like whiB1 3548449 whiB1_1 4698039 whiB1_1 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein whiB-like whiB1 YP_979330.1 3548195 D 410289 CDS YP_979331.1 121639107 4695497 complement(3548511..3550016) 1 NC_008769.1 Differs from Rv3220c by 1aa, N47D; two component sensor kinase 3550016 4695497 BCG_3247c Mycobacterium bovis BCG str. Pasteur 1173P2 two component sensor kinase YP_979331.1 3548511 R 410289 CDS YP_979332.1 121639108 4698146 complement(3550033..3550248) 1 NC_008769.1 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3550248 TB7.3_1 4698146 TB7.3_1 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_979332.1 3550033 R 410289 CDS YP_979333.1 121639109 4696425 complement(3550533..3550838) 1 NC_008769.1 anti-sigma factor 3550838 4696425 BCG_3249c Mycobacterium bovis BCG str. Pasteur 1173P2 anti-sigma factor YP_979333.1 3550533 R 410289 CDS YP_979334.1 121639110 4698125 complement(3550835..3551386) 1 NC_008769.1 hypothetical protein 3551386 4698125 BCG_3250c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979334.1 3550835 R 410289 CDS YP_979335.1 121639111 4698266 complement(3551383..3552033) 1 NC_008769.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 3552033 sigH_1 4698266 sigH_1 Mycobacterium bovis BCG str. Pasteur 1173P2 RNA polymerase sigma factor RpoE YP_979335.1 3551383 R 410289 CDS YP_979336.1 121639112 4695355 3552333..3553181 1 NC_008769.1 short chain dehydrogenase 3553181 4695355 BCG_3252 Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_979336.1 3552333 D 410289 CDS YP_979337.1 121639113 4698380 3553117..3553305 1 NC_008769.1 hypothetical protein 3553305 4698380 BCG_3253 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979337.1 3553117 D 410289 CDS YP_979338.1 121639114 4699265 3553283..3553501 1 NC_008769.1 hypothetical protein 3553501 4699265 BCG_3254 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979338.1 3553283 D 410289 CDS YP_979339.1 121639115 4698200 complement(3553498..3554922) 1 NC_008769.1 Differs from Rv3225c by 1aa T306A; transferase 3554922 4698200 BCG_3255c Mycobacterium bovis BCG str. Pasteur 1173P2 transferase YP_979339.1 3553498 R 410289 CDS YP_979340.1 121639116 4699348 complement(3555046..3555804) 1 NC_008769.1 hypothetical protein 3555804 4699348 BCG_3256c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979340.1 3555046 R 410289 CDS YP_979341.1 121639117 4698762 3555859..3557211 1 NC_008769.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 3557211 aroA_1 4698762 aroA_1 Mycobacterium bovis BCG str. Pasteur 1173P2 3-phosphoshikimate 1-carboxyvinyltransferase YP_979341.1 3555859 D 410289 CDS YP_979342.1 121639118 4698765 3557208..3558200 1 NC_008769.1 Differs from Rv3228, Mb3257 and BCG_3351 by 1aa, D169G; hypothetical protein 3558200 4698765 BCG_3258 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979342.1 3557208 D 410289 CDS YP_979343.1 121639119 4699317 complement(3558233..3559516) 1 NC_008769.1 linoleoyl-CoA desaturase 3559516 desA3_1 4699317 desA3_1 Mycobacterium bovis BCG str. Pasteur 1173P2 linoleoyl-CoA desaturase YP_979343.1 3558233 R 410289 CDS YP_979344.1 121639120 4696176 complement(3559594..3560736) 1 NC_008769.1 Differs from Rv3230c by 1aa, C105R; oxidoreductase 3560736 4696176 BCG_3260c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979344.1 3559594 R 410289 CDS YP_979345.1 121639121 4698625 complement(3560846..3561355) 1 NC_008769.1 IN DU2, the second copy (BCG_3355c) is truncated; hypothetical protein 3561355 4698625 BCG_3261c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979345.1 3560846 R 410289 CDS YP_979346.1 121639122 4699187 complement(3561352..3562239) 1 NC_008769.1 transcriptional regulatory protein pvdS 3562239 pvdS 4699187 pvdS Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein pvdS YP_979346.1 3561352 R 410289 CDS YP_979347.1 121639123 4696881 complement(3562263..3563672) 1 NC_008769.1 In Mycobacterium tuberculosis H37Rv, Rv3234c and Rv3233c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-g) leads to a single product that is more similar to Rv3234c; hypothetical protein 3563672 4696881 BCG_3263c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979347.1 3562263 R 410289 CDS YP_979348.1 121639124 4698677 3563783..3564424 1 NC_008769.1 hypothetical protein 3564424 4698677 BCG_3264 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979348.1 3563783 D 410289 CDS YP_979349.1 121639125 4698989 complement(3564442..3565599) 1 NC_008769.1 integral membrane transport protein 3565599 4698989 BCG_3265c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane transport protein YP_979349.1 3564442 R 410289 CDS YP_979350.1 121639126 4698341 complement(3565604..3566086) 1 NC_008769.1 hypothetical protein 3566086 4698341 BCG_3266c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979350.1 3565604 R 410289 CDS YP_979351.1 121639127 4699025 complement(3566147..3566881) 1 NC_008769.1 integral membrane protein 3566881 4699025 BCG_3267c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_979351.1 3566147 R 410289 CDS YP_979352.1 121639128 4698984 complement(3566940..3570086) 1 NC_008769.1 Differs from Mb3267c by 1aa, R867H; transmembrane transport protein 3570086 4698984 BCG_3268c Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane transport protein YP_979352.1 3566940 R 410289 CDS YP_979353.1 121639129 4698500 complement(3570165..3573014) 1 NC_008769.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 3573014 secA1 4698500 secA1 Mycobacterium bovis BCG str. Pasteur 1173P2 preprotein translocase subunit SecA YP_979353.1 3570165 R 410289 CDS YP_979354.1 121639130 4697250 complement(3573093..3573737) 1 NC_008769.1 hypothetical protein 3573737 4697250 BCG_3270c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979354.1 3573093 R 410289 CDS YP_979355.1 121639131 4699061 complement(3574053..3574694) 1 NC_008769.1 Differs from Rv3242c and Mb3270c by 1aa, S89L; hypothetical protein 3574694 4699061 BCG_3271c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979355.1 3574053 R 410289 CDS YP_979356.1 121639132 4698515 complement(3574732..3575574) 1 NC_008769.1 hypothetical protein 3575574 4698515 BCG_3272c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979356.1 3574732 R 410289 CDS YP_979357.1 121639133 4699297 complement(3575642..3577393) 1 NC_008769.1 Differs from Rv3244c by 2aa, G142D, L394S; lipoprotein LpqB 3577393 lpqB 4699297 lpqB Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein LpqB YP_979357.1 3575642 R 410289 CDS YP_979358.1 121639134 4698617 complement(3577393..3579096) 1 NC_008769.1 Differs from Rv3245c by 1aa, L517M; two component sensory transduction histidine kinase mtrB 3579096 mtrB 4698617 mtrB Mycobacterium bovis BCG str. Pasteur 1173P2 two component sensory transduction histidine kinase mtrB YP_979358.1 3577393 R 410289 CDS YP_979359.1 121639135 4699150 complement(3579146..3579832) 1 NC_008769.1 two component sensory transduction transcriptional regulatory protein mtrA 3579832 mtrA 4699150 mtrA Mycobacterium bovis BCG str. Pasteur 1173P2 two component sensory transduction transcriptional regulatory protein mtrA YP_979359.1 3579146 R 410289 CDS YP_979360.1 121639136 4699149 complement(3579902..3580546) 1 NC_008769.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 3580546 tmk 4699149 tmk Mycobacterium bovis BCG str. Pasteur 1173P2 thymidylate kinase YP_979360.1 3579902 R 410289 CDS YP_979361.1 121639137 4696387 complement(3580643..3582130) 1 NC_008769.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase 3582130 sahH 4696387 sahH Mycobacterium bovis BCG str. Pasteur 1173P2 S-adenosyl-L-homocysteine hydrolase YP_979361.1 3580643 R 410289 CDS YP_979362.1 121639138 4697894 complement(3582235..3582870) 1 NC_008769.1 TetR family transcriptional regulator 3582870 4697894 BCG_3278c Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_979362.1 3582235 R 410289 CDS YP_979363.1 121639139 4698475 complement(3582867..3583049) 1 NC_008769.1 rubredoxin rubB 3583049 4698475 BCG_3279c Mycobacterium bovis BCG str. Pasteur 1173P2 rubredoxin rubB YP_979363.1 3582867 R 410289 CDS YP_979364.1 121639140 4698965 complement(3583054..3583221) 1 NC_008769.1 rubredoxin rubA 3583221 4698965 BCG_3280c Mycobacterium bovis BCG str. Pasteur 1173P2 rubredoxin rubA YP_979364.1 3583054 R 410289 CDS YP_979365.1 121639141 4698539 complement(3583221..3584471) 1 NC_008769.1 transmembrane alkane 1-monooxygenase alkB 3584471 alkB 4698539 alkB Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane alkane 1-monooxygenase alkB YP_979365.1 3583221 R 410289 CDS YP_979366.1 121639142 4696195 complement(3584580..3586067) 1 NC_008769.1 cationic amino acid transport integral membrane protein 3586067 4696195 BCG_3282c Mycobacterium bovis BCG str. Pasteur 1173P2 cationic amino acid transport integral membrane protein YP_979366.1 3584580 R 410289 CDS YP_979367.1 121639143 4698876 3586158..3587546 1 NC_008769.1 hypothetical protein 3587546 4698876 BCG_3283 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979367.1 3586158 D 410289 CDS YP_979368.1 121639144 4698815 complement(3587524..3588750) 1 NC_008769.1 mannose-6-phosphate isomerase manA 3588750 manA 4698815 manA Mycobacterium bovis BCG str. Pasteur 1173P2 mannose-6-phosphate isomerase manA YP_979368.1 3587524 R 410289 CDS YP_979369.1 121639145 4698308 complement(3588758..3589798) 1 NC_008769.1 hypothetical protein 3589798 4698308 BCG_3285c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979369.1 3588758 R 410289 CDS YP_979370.1 121639146 4698271 complement(3589795..3591192) 1 NC_008769.1 converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells; phosphomannomutase 3591192 manB 4698271 manB Mycobacterium bovis BCG str. Pasteur 1173P2 phosphomannomutase YP_979370.1 3589795 R 410289 CDS YP_979371.1 121639147 4698309 complement(3591294..3591785) 1 NC_008769.1 hypothetical protein 3591785 4698309 BCG_3287c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979371.1 3591294 R 410289 CDS YP_979372.1 121639148 4698235 3591908..3592327 1 NC_008769.1 hypothetical protein 3592327 4698235 BCG_3288 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979372.1 3591908 D 410289 CDS YP_979373.1 121639149 4698199 complement(3592355..3592624) 1 NC_008769.1 transcriptional regulatory protein whiB-like whiB2 3592624 whiB2 4698199 whiB2 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein whiB-like whiB2 YP_979373.1 3592355 R 410289 CDS YP_979374.1 121639150 4695499 3593026..3594021 1 NC_008769.1 catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); LPPG:FO 2-phospho-L-lactate transferase 3594021 fbiA 4695499 fbiA Mycobacterium bovis BCG str. Pasteur 1173P2 LPPG:FO 2-phospho-L-lactate transferase YP_979374.1 3593026 D 410289 CDS YP_979375.1 121639151 4696561 3594018..3595364 1 NC_008769.1 catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0); F420-0--gamma-glutamyl ligase 3595364 fbiB 4696561 fbiB Mycobacterium bovis BCG str. Pasteur 1173P2 F420-0--gamma-glutamyl ligase YP_979375.1 3594018 D 410289 CDS YP_979376.1 121639152 4696562 3595660..3597321 1 NC_008769.1 DNA methylase 3597321 4696562 BCG_3292 Mycobacterium bovis BCG str. Pasteur 1173P2 DNA methylase YP_979376.1 3595660 D 410289 CDS YP_979377.1 121639153 4696035 complement(3597381..3598460) 1 NC_008769.1 mannose-1-phosphate guanyltransferase manC 3598460 manC 4696035 manC Mycobacterium bovis BCG str. Pasteur 1173P2 mannose-1-phosphate guanyltransferase manC YP_979377.1 3597381 R 410289 CDS YP_979378.1 121639154 4698310 complement(3598462..3599355) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, an in-frame deletion of 12 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (297 aa versus 301 aa); dTDP-RHA:A-D-GlcNAc-diphosphoryl polyprenol, A-3-L-rhamnosyl transferase wbbL1 3599355 wbbL1 4698310 wbbL1 Mycobacterium bovis BCG str. Pasteur 1173P2 dTDP-RHA:A-D-GlcNAc-diphosphoryl polyprenol, A-3-L-rhamnosyl transferase wbbL1 YP_979378.1 3598462 R 410289 CDS YP_979379.1 121639155 4697891 complement(3599366..3600280) 1 NC_008769.1 Differs from Rv3266c by 1aa, P257S; dTDP-rhamnose modification protein rmlD 3600280 rmld 4697891 rmld Mycobacterium bovis BCG str. Pasteur 1173P2 dTDP-rhamnose modification protein rmlD YP_979379.1 3599366 R 410289 CDS YP_979380.1 121639156 4697605 3600356..3601852 1 NC_008769.1 hypothetical protein 3601852 4697605 BCG_3296 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979380.1 3600356 D 410289 CDS YP_979381.1 121639157 4698490 3601891..3602580 1 NC_008769.1 hypothetical protein 3602580 4698490 BCG_3297 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979381.1 3601891 D 410289 CDS YP_979382.1 121639158 4698710 3602705..3602986 1 NC_008769.1 hypothetical protein 3602986 4698710 BCG_3298 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979382.1 3602705 D 410289 CDS YP_979383.1 121639159 4699346 3602997..3605153 1 NC_008769.1 metal cation-transporting P-type atpase C ctpC 3605153 ctpC 4699346 ctpC Mycobacterium bovis BCG str. Pasteur 1173P2 metal cation-transporting P-type atpase C ctpC YP_979383.1 3602997 D 410289 CDS YP_979384.1 121639160 4697501 complement(3605150..3605818) 1 NC_008769.1 integral membrane protein 3605818 4697501 BCG_3300c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_979384.1 3605150 R 410289 CDS YP_979385.1 121639161 4698970 3605919..3607103 1 NC_008769.1 Differs from Mb3300 by 1aa, R259G, and from Rv3272 by 2aa, R259G, S347N; hypothetical protein 3607103 4698970 BCG_3301 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979385.1 3605919 D 410289 CDS YP_979386.1 121639162 4699109 3607108..3609402 1 NC_008769.1 transmembrane carbonic anhydrase 3609402 4699109 BCG_3302 Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane carbonic anhydrase YP_979386.1 3607108 D 410289 CDS YP_979387.1 121639163 4698979 complement(3609391..3610560) 1 NC_008769.1 acyl-CoA dehydrogenase fadE25 3610560 fadE25 4698979 fadE25 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE25 YP_979387.1 3609391 R 410289 CDS YP_979388.1 121639164 4697413 complement(3610585..3611109) 1 NC_008769.1 Differs from Rv3275c by 1aa, R125G; phosphoribosylaminoimidazole carboxylase catalytic subunit purE 3611109 purE 4697413 purE Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoribosylaminoimidazole carboxylase catalytic subunit purE YP_979388.1 3610585 R 410289 CDS YP_979389.1 121639165 4696431 complement(3611106..3612395) 1 NC_008769.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 3612395 purK 4696431 purK Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_979389.1 3611106 R 410289 CDS YP_979390.1 121639166 4696434 3612349..3613167 1 NC_008769.1 Differs from Rv3277 by 1 aa, L272S; hypothetical protein 3613167 4696434 BCG_3306 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979390.1 3612349 D 410289 CDS YP_979391.1 121639167 4698407 complement(3613122..3613640) 1 NC_008769.1 Differs from Rv3278c by 1aa, K160E; hypothetical protein 3613640 4698407 BCG_3307c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979391.1 3613122 R 410289 CDS YP_979392.1 121639168 4698074 complement(3613683..3614483) 1 NC_008769.1 Differs from Rv3279c by 1aa, N211D; bifunctional protein birA: biotin operon repressor + biotin--[acetyl-coa-carboxylase] synthetase 3614483 birA 4698074 birA Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional protein birA: biotin operon repressor + biotin--[acetyl-coa-carboxylase] synthetase YP_979392.1 3613683 R 410289 CDS YP_979393.1 121639169 4696128 3614533..3616179 1 NC_008769.1 Differs from Rv3280 by 1aa, A448V; propionyl-CoA carboxylase beta chain 5 accD5 3616179 accD5 4696128 accD5 Mycobacterium bovis BCG str. Pasteur 1173P2 propionyl-CoA carboxylase beta chain 5 accD5 YP_979393.1 3614533 D 410289 CDS YP_979394.1 121639170 4698862 3616160..3616630 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, an in-frame deletion of 63 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (156 aa versus 177 aa). Loss of tandem repeat SRVSGTNEVSDGNETNNPAPV; hypothetical protein 3616630 4698862 BCG_3310 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979394.1 3616160 D 410289 CDS YP_979395.1 121639171 4698263 3616627..3617295 1 NC_008769.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 3617295 4698263 BCG_3311 Mycobacterium bovis BCG str. Pasteur 1173P2 Maf-like protein YP_979395.1 3616627 D 410289 CDS YP_979396.1 121639172 4699030 3617336..3618229 1 NC_008769.1 Differs from Mb3311 by 1aa, G170D; thiosulfate sulfurtransferase sseA 3618229 sseA 4699030 sseA Mycobacterium bovis BCG str. Pasteur 1173P2 thiosulfate sulfurtransferase sseA YP_979396.1 3617336 D 410289 CDS YP_979397.1 121639173 4696753 3618226..3618657 1 NC_008769.1 hypothetical protein 3618657 4696753 BCG_3313 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979397.1 3618226 D 410289 CDS YP_979398.1 121639174 4699098 3618765..3620567 1 NC_008769.1 bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (alpha chain) accA3: biotin carboxylase + biotin carboxyl carrier protein 3620567 accA3 4699098 accA3 Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (alpha chain) accA3: biotin carboxylase + biotin carboxyl carrier protein YP_979398.1 3618765 D 410289 CDS YP_979399.1 121639175 4698702 complement(3620577..3621362) 1 NC_008769.1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is a general stress response regulator; expressed in stationary phase and under nitrogen depletion and cold shock; RNA polymerase sigma factor SigF 3621362 sigF 4698702 sigF Mycobacterium bovis BCG str. Pasteur 1173P2 RNA polymerase sigma factor SigF YP_979399.1 3620577 R 410289 CDS YP_979400.1 121639176 4695818 complement(3621359..3621796) 1 NC_008769.1 anti-sigma factor rsbW 3621796 rsbW 4695818 rsbW Mycobacterium bovis BCG str. Pasteur 1173P2 anti-sigma factor rsbW YP_979400.1 3621359 R 410289 CDS YP_979401.1 121639177 4697805 complement(3621994..3622407) 1 NC_008769.1 protein usfY 3622407 usfY 4697805 usfY Mycobacterium bovis BCG str. Pasteur 1173P2 protein usfY YP_979401.1 3621994 R 410289 CDS YP_979402.1 121639178 4695769 complement(3622442..3622819) 1 NC_008769.1 hypothetical protein 3622819 4695769 BCG_3318c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979402.1 3622442 R 410289 CDS YP_979403.1 121639179 4698878 complement(3622853..3624202) 1 NC_008769.1 catalyzes the formation of 2-aminoadipate 6-semiladehyde and glutamate from lysine and 2-oxoglutarate; L-lysine aminotransferase 3624202 lat 4698878 lat Mycobacterium bovis BCG str. Pasteur 1173P2 L-lysine aminotransferase YP_979403.1 3622853 R 410289 CDS YP_979404.1 121639180 4695954 complement(3624253..3624705) 1 NC_008769.1 Differs from Rv3291c by 1aa, V22A; AsnC family transcriptional regulator 3624705 4695954 BCG_3320c Mycobacterium bovis BCG str. Pasteur 1173P2 AsnC family transcriptional regulator YP_979404.1 3624253 R 410289 CDS YP_979405.1 121639181 4698957 3624736..3625983 1 NC_008769.1 hypothetical protein 3625983 4698957 BCG_3321 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979405.1 3624736 D 410289 CDS YP_979406.1 121639182 4698806 3626010..3627494 1 NC_008769.1 Differs from Rv3293 by 1aa, C273G; piperideine-6-carboxilic acid dehydrogenase pcd 3627494 pcd_1 4698806 pcd_1 Mycobacterium bovis BCG str. Pasteur 1173P2 piperideine-6-carboxilic acid dehydrogenase pcd YP_979406.1 3626010 D 410289 CDS YP_979407.1 121639183 4698837 complement(3627594..3628403) 1 NC_008769.1 hypothetical protein 3628403 4698837 BCG_3323c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979407.1 3627594 R 410289 CDS YP_979408.1 121639184 4698667 3628474..3629139 1 NC_008769.1 TetR family transcriptional regulator 3629139 4698667 BCG_3324 Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_979408.1 3628474 D 410289 CDS YP_979409.1 121639185 4699268 3629183..3633724 1 NC_008769.1 Differs from Rv3296 by 3aa, M719V, N818D, E1059K; ATP-dependent helicase lhr 3633724 lhr_1 4699268 lhr_1 Mycobacterium bovis BCG str. Pasteur 1173P2 ATP-dependent helicase lhr YP_979409.1 3629183 D 410289 CDS YP_979410.1 121639186 4697270 3633728..3634495 1 NC_008769.1 endonuclease VIII nei 3634495 nei_1 4697270 nei_1 Mycobacterium bovis BCG str. Pasteur 1173P2 endonuclease VIII nei YP_979410.1 3633728 D 410289 CDS YP_979411.1 121639187 4696140 complement(3634518..3635432) 1 NC_008769.1 esterase lipoprotein lpqC 3635432 lpqC_1 4696140 lpqC_1 Mycobacterium bovis BCG str. Pasteur 1173P2 esterase lipoprotein lpqC YP_979411.1 3634518 R 410289 CDS YP_979412.1 121639188 4696105 complement(3635459..3638371) 1 NC_008769.1 Differs from Rv3299c by 1aa, S204G; arylsulfatase atsB 3638371 atsB 4696105 atsB Mycobacterium bovis BCG str. Pasteur 1173P2 arylsulfatase atsB YP_979412.1 3635459 R 410289 CDS YP_979413.1 121639189 4698657 complement(3638391..3639308) 1 NC_008769.1 Differs from Mb3328c by 1aa, D52N; hypothetical protein 3639308 4698657 BCG_3329c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979413.1 3638391 R 410289 CDS YP_979414.1 121639190 4699211 complement(3639320..3639985) 1 NC_008769.1 Differs from Rv3301c and Mb3329c by 1aa, S74A; phosphate-transport system transcriptional regulatory protein phoU 1 phoY1 3639985 phoY1_1 4699211 phoY1_1 Mycobacterium bovis BCG str. Pasteur 1173P2 phosphate-transport system transcriptional regulatory protein phoU 1 phoY1 YP_979414.1 3639320 R 410289 CDS YP_979415.1 121639191 4698181 complement(3640093..3641850) 1 NC_008769.1 glycerol-3-phosphate dehydrogenase glpD2 3641850 glpD2_1 4698181 glpD2_1 Mycobacterium bovis BCG str. Pasteur 1173P2 glycerol-3-phosphate dehydrogenase glpD2 YP_979415.1 3640093 R 410289 CDS YP_979416.1 121639192 4698637 complement(3642530..3643126) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, Mb3333c is truncated compared to its homologs in Mycobacterium tuberculosis strain H37Rv (Rv3213c) and Mycobacterium bovis AF2122/97 (Mb3239c). It contains one endpoint of BCG-specific tandem duplication region, DU2. Differs from Rv3213c by 2aa, E144K and P198L; soj/parA-related protein 3643126 4698637 BCG_3333c Mycobacterium bovis BCG str. Pasteur 1173P2 soj/parA-related protein YP_979416.1 3642530 R 410289 CDS YP_979417.1 121639193 4698360 3643280..3643891 1 NC_008769.1 forms a homodimer in Mycobacterium tuberculosis; belongs to the dPGM superfamily; acid phosphatase 3643891 gpm2_2 4698360 gpm2_2 Mycobacterium bovis BCG str. Pasteur 1173P2 acid phosphatase YP_979417.1 3643280 D 410289 CDS YP_979418.1 121639194 4697842 3643888..3645006 1 NC_008769.1 isochorismate synthase entC 3645006 entC_2 4697842 entC_2 Mycobacterium bovis BCG str. Pasteur 1173P2 isochorismate synthase entC YP_979418.1 3643888 D 410289 CDS YP_979419.1 121639195 4699016 3645154..3645486 1 NC_008769.1 acetyltransferase 3645486 4699016 BCG_3336 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyltransferase YP_979419.1 3645154 D 410289 CDS YP_979420.1 121639196 4698510 complement(3645438..3645869) 1 NC_008769.1 integral membrane protein 3645869 4698510 BCG_3337c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_979420.1 3645438 R 410289 CDS YP_979421.1 121639197 4698694 3646102..3647067 1 NC_008769.1 hypothetical protein 3647067 4698694 BCG_3338 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979421.1 3646102 D 410289 CDS YP_979422.1 121639198 4698449 3647347..3647601 1 NC_008769.1 transcriptional regulatory protein whiB-like whiB1 3647601 whiB1_2 4698449 whiB1_2 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein whiB-like whiB1 YP_979422.1 3647347 D 410289 CDS YP_979423.1 121639199 4695498 complement(3647663..3649168) 1 NC_008769.1 Differs from Rv3220c by 1aa, N47D; two component sensor kinase 3649168 4695498 BCG_3340c Mycobacterium bovis BCG str. Pasteur 1173P2 two component sensor kinase YP_979423.1 3647663 R 410289 CDS YP_979424.1 121639200 4698186 complement(3649185..3649400) 1 NC_008769.1 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3649400 TB7.3_2 4698186 TB7.3_2 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_979424.1 3649185 R 410289 CDS YP_979425.1 121639201 4696426 complement(3649685..3649990) 1 NC_008769.1 anti-sigma factor 3649990 4696426 BCG_3342c Mycobacterium bovis BCG str. Pasteur 1173P2 anti-sigma factor YP_979425.1 3649685 R 410289 CDS YP_979426.1 121639202 4699053 complement(3649987..3650538) 1 NC_008769.1 hypothetical protein 3650538 4699053 BCG_3343c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979426.1 3649987 R 410289 CDS YP_979427.1 121639203 4698719 complement(3650535..3651185) 1 NC_008769.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 3651185 sigH_2 4698719 sigH_2 Mycobacterium bovis BCG str. Pasteur 1173P2 RNA polymerase sigma factor RpoE YP_979427.1 3650535 R 410289 CDS YP_979428.1 121639204 4695356 3651485..3652333 1 NC_008769.1 short chain dehydrogenase 3652333 4695356 BCG_3345 Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_979428.1 3651485 D 410289 CDS YP_979429.1 121639205 4698516 3652269..3652457 1 NC_008769.1 hypothetical protein 3652457 4698516 BCG_3346 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979429.1 3652269 D 410289 CDS YP_979430.1 121639206 4699258 3652435..3652653 1 NC_008769.1 hypothetical protein 3652653 4699258 BCG_3347 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979430.1 3652435 D 410289 CDS YP_979431.1 121639207 4699023 complement(3652650..3654074) 1 NC_008769.1 Differs from Rv3225c by 1aa, T305A; transferase 3654074 4699023 BCG_3348c Mycobacterium bovis BCG str. Pasteur 1173P2 transferase YP_979431.1 3652650 R 410289 CDS YP_979432.1 121639208 4698314 complement(3654198..3654956) 1 NC_008769.1 hypothetical protein 3654956 4698314 BCG_3349c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979432.1 3654198 R 410289 CDS YP_979433.1 121639209 4698554 3655011..3656363 1 NC_008769.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 3656363 aroA_2 4698554 aroA_2 Mycobacterium bovis BCG str. Pasteur 1173P2 3-phosphoshikimate 1-carboxyvinyltransferase YP_979433.1 3655011 D 410289 CDS YP_979434.1 121639210 4695659 3656360..3657352 1 NC_008769.1 Differs from BCG_3258 by 1aa, G169D; hypothetical protein 3657352 4695659 BCG_3351 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979434.1 3656360 D 410289 CDS YP_979435.1 121639211 4698918 complement(3657385..3658668) 1 NC_008769.1 linoleoyl-CoA desaturase desA3 3658668 desA3_2 4698918 desA3_2 Mycobacterium bovis BCG str. Pasteur 1173P2 linoleoyl-CoA desaturase desA3 YP_979435.1 3657385 R 410289 CDS YP_979436.1 121639212 4698005 complement(3658746..3659888) 1 NC_008769.1 Differs from Rv3230c by 1aa, C105R; oxidoreductase 3659888 4698005 BCG_3353c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979436.1 3658746 R 410289 CDS YP_979437.1 121639213 4699046 complement(3659943..3660365) 1 NC_008769.1 Internal deletion of DU2 leads to a truncated copy of Rv3231c and of Rv3290c; L-lysine-epsilon aminotransferase lat' 3660365 lat' 4699046 lat' Mycobacterium bovis BCG str. Pasteur 1173P2 L-lysine-epsilon aminotransferase lat' YP_979437.1 3659943 R 410289 CDS YP_979438.1 121639214 4695955 complement(3660416..3660868) 1 NC_008769.1 Differs from Rv3291c by 1aa, V22A; AsnC family transcriptional regulator 3660868 4695955 BCG_3356c Mycobacterium bovis BCG str. Pasteur 1173P2 AsnC family transcriptional regulator YP_979438.1 3660416 R 410289 CDS YP_979439.1 121639215 4699332 3660899..3662146 1 NC_008769.1 hypothetical protein 3662146 4699332 BCG_3357 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979439.1 3660899 D 410289 CDS YP_979440.1 121639216 4699282 3662173..3663657 1 NC_008769.1 Differs from Rv3293 by 1aa, C273G; piperideine-6-carboxilic acid dehydrogenase pcd 3663657 pcd_2 4699282 pcd_2 Mycobacterium bovis BCG str. Pasteur 1173P2 piperideine-6-carboxilic acid dehydrogenase pcd YP_979440.1 3662173 D 410289 CDS YP_979441.1 121639217 4698417 complement(3663757..3664566) 1 NC_008769.1 hypothetical protein 3664566 4698417 BCG_3359c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979441.1 3663757 R 410289 CDS YP_979442.1 121639218 4698378 3664637..3665302 1 NC_008769.1 TetR family transcriptional regulator 3665302 4698378 BCG_3360 Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_979442.1 3664637 D 410289 CDS YP_979443.1 121639219 4698521 3665346..3669887 1 NC_008769.1 Differs from Rv3296 by 3aa, M719V, N818D, E1059K; atp-dependent helicase lhr 3669887 lhr_2 4698521 lhr_2 Mycobacterium bovis BCG str. Pasteur 1173P2 atp-dependent helicase lhr YP_979443.1 3665346 D 410289 CDS YP_979444.1 121639220 4697271 3669891..3670658 1 NC_008769.1 endonuclease VIII nei 3670658 nei_2 4697271 nei_2 Mycobacterium bovis BCG str. Pasteur 1173P2 endonuclease VIII nei YP_979444.1 3669891 D 410289 CDS YP_979445.1 121639221 4699203 complement(3670681..3671595) 1 NC_008769.1 esterase lipoprotein lpqC 3671595 lpqC_2 4699203 lpqC_2 Mycobacterium bovis BCG str. Pasteur 1173P2 esterase lipoprotein lpqC YP_979445.1 3670681 R 410289 CDS YP_979446.1 121639222 4696106 complement(3671622..3674534) 1 NC_008769.1 Differs from Rv3299c by 1aa, S204G; arylsulfatase atsB 3674534 atsB_2 4696106 atsB_2 Mycobacterium bovis BCG str. Pasteur 1173P2 arylsulfatase atsB YP_979446.1 3671622 R 410289 CDS YP_979447.1 121639223 4695704 complement(3674554..3675471) 1 NC_008769.1 Differs from Mb3328c by 1aa, D52N; hypothetical protein 3675471 4695704 BCG_3365c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979447.1 3674554 R 410289 CDS YP_979448.1 121639224 4699156 complement(3675483..3676148) 1 NC_008769.1 Differs from Rv3301c and Mb3329c by 1aa, S74A; phosphate-transport system transcriptional regulatory protein phoU 1 phoY1 3676148 phoY1_2 4699156 phoY1_2 Mycobacterium bovis BCG str. Pasteur 1173P2 phosphate-transport system transcriptional regulatory protein phoU 1 phoY1 YP_979448.1 3675483 R 410289 CDS YP_979449.1 121639225 4698182 complement(3676256..3678013) 1 NC_008769.1 glycerol-3-phosphate dehydrogenase glpD2 3678013 glpD2_2 4698182 glpD2_2 Mycobacterium bovis BCG str. Pasteur 1173P2 glycerol-3-phosphate dehydrogenase glpD2 YP_979449.1 3676256 R 410289 CDS YP_979450.1 121639226 4697770 complement(3678094..3679509) 1 NC_008769.1 catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; flavoprotein disulfide reductase 3679509 lpdA 4697770 lpdA Mycobacterium bovis BCG str. Pasteur 1173P2 flavoprotein disulfide reductase YP_979450.1 3678094 R 410289 CDS YP_979451.1 121639227 4699198 3679712..3680191 1 NC_008769.1 hypothetical protein 3680191 4699198 BCG_3369 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979451.1 3679712 D 410289 CDS YP_979452.1 121639228 4699033 complement(3680210..3681379) 1 NC_008769.1 N-acyl-L-amino acid amidohydrolase amiA1 3681379 amiA1 4699033 amiA1 Mycobacterium bovis BCG str. Pasteur 1173P2 N-acyl-L-amino acid amidohydrolase amiA1 YP_979452.1 3680210 R 410289 CDS YP_979453.1 121639229 4696149 complement(3681376..3682560) 1 NC_008769.1 amidase amiB1 3682560 amiB1 4696149 amiB1 Mycobacterium bovis BCG str. Pasteur 1173P2 amidase amiB1 YP_979453.1 3681376 R 410289 CDS YP_979454.1 121639230 4696234 3682625..3683431 1 NC_008769.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 3683431 deoD 4696234 deoD Mycobacterium bovis BCG str. Pasteur 1173P2 purine nucleoside phosphorylase YP_979454.1 3682625 D 410289 CDS YP_979455.1 121639231 4698848 3683435..3685039 1 NC_008769.1 Differs from Rv3308 by 1aa, G440S; phosphomannomutase pmmB 3685039 pmmB 4698848 pmmB Mycobacterium bovis BCG str. Pasteur 1173P2 phosphomannomutase pmmB YP_979455.1 3683435 D 410289 CDS YP_979456.1 121639232 4696814 complement(3685041..3685664) 1 NC_008769.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 3685664 upp 4696814 upp Mycobacterium bovis BCG str. Pasteur 1173P2 uracil phosphoribosyltransferase YP_979456.1 3685041 R 410289 CDS YP_979457.1 121639233 4696502 3685769..3686668 1 NC_008769.1 Differs from Rv3310 by 1aa, A171T; acid phosphatase 3686668 sapM 4696502 sapM Mycobacterium bovis BCG str. Pasteur 1173P2 acid phosphatase YP_979457.1 3685769 D 410289 CDS YP_979458.1 121639234 4697895 3686692..3687954 1 NC_008769.1 hypothetical protein 3687954 4697895 BCG_3376 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979458.1 3686692 D 410289 CDS YP_979459.1 121639235 4699032 complement(3687975..3688901) 1 NC_008769.1 hypothetical protein 3688901 4699032 BCG_3377c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979459.1 3687975 R 410289 CDS YP_979460.1 121639236 4698338 complement(3689276..3689587) 1 NC_008769.1 hypothetical protein 3689587 4698338 BCG_3378c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979460.1 3689276 R 410289 CDS YP_979461.1 121639237 4698245 complement(3689658..3690755) 1 NC_008769.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 3690755 add 4698245 add Mycobacterium bovis BCG str. Pasteur 1173P2 adenosine deaminase YP_979461.1 3689658 R 410289 CDS YP_979462.1 121639238 4697885 complement(3690755..3692038) 1 NC_008769.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 3692038 deoA 4697885 deoA Mycobacterium bovis BCG str. Pasteur 1173P2 thymidine phosphorylase YP_979462.1 3690755 R 410289 CDS YP_979463.1 121639239 4696742 complement(3692035..3692436) 1 NC_008769.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 3692436 cdd 4696742 cdd Mycobacterium bovis BCG str. Pasteur 1173P2 cytidine deaminase YP_979463.1 3692035 R 410289 CDS YP_979464.1 121639240 4697614 3692673..3693011 1 NC_008769.1 succinate dehydrogenase (cytochrome B-556 subunit) SDHC 3693011 sdhC 4697614 sdhC Mycobacterium bovis BCG str. Pasteur 1173P2 succinate dehydrogenase (cytochrome B-556 subunit) SDHC YP_979464.1 3692673 D 410289 CDS YP_979465.1 121639241 4697248 3693008..3693442 1 NC_008769.1 Differs from Rv3317 by 1aa, L54V; succinate dehydrogenase (hydrophobic membrane anchor subunit) sdhD 3693442 sdhD 4697248 sdhD Mycobacterium bovis BCG str. Pasteur 1173P2 succinate dehydrogenase (hydrophobic membrane anchor subunit) sdhD YP_979465.1 3693008 D 410289 CDS YP_979466.1 121639242 4697249 3693571..3695343 1 NC_008769.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 3695343 sdhA 4697249 sdhA Mycobacterium bovis BCG str. Pasteur 1173P2 succinate dehydrogenase flavoprotein subunit YP_979466.1 3693571 D 410289 CDS YP_979467.1 121639243 4697246 3695343..3696134 1 NC_008769.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 3696134 sdhB 4697246 sdhB Mycobacterium bovis BCG str. Pasteur 1173P2 succinate dehydrogenase iron-sulfur subunit YP_979467.1 3695343 D 410289 CDS YP_979468.1 121639244 4697247 complement(3696213..3696641) 1 NC_008769.1 hypothetical protein 3696641 4697247 BCG_3386c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979468.1 3696213 R 410289 CDS YP_979469.1 121639245 4698894 complement(3696645..3696887) 1 NC_008769.1 hypothetical protein 3696887 4698894 BCG_3387c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979469.1 3696645 R 410289 CDS YP_979470.1 121639246 4698034 complement(3697009..3697623) 1 NC_008769.1 methyltransferase 3697623 4698034 BCG_3388c Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase YP_979470.1 3697009 R 410289 CDS YP_979471.1 121639247 4698884 complement(3697620..3698285) 1 NC_008769.1 moaD-moaE fusion protein moaX 3698285 moaX 4698884 moaX Mycobacterium bovis BCG str. Pasteur 1173P2 moaD-moaE fusion protein moaX YP_979471.1 3697620 R 410289 CDS YP_979472.1 121639248 4698497 complement(3698286..3698819) 1 NC_008769.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 3698819 moaC 4698497 moaC Mycobacterium bovis BCG str. Pasteur 1173P2 molybdenum cofactor biosynthesis protein MoaC YP_979472.1 3698286 R 410289 CDS YP_979473.1 121639249 4698493 complement(3698816..3699190) 1 NC_008769.1 Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv; pterin-4-alpha-carbinolamine dehydratase moaB3 3699190 moaB3 4698493 moaB3 Mycobacterium bovis BCG str. Pasteur 1173P2 pterin-4-alpha-carbinolamine dehydratase moaB3 YP_979473.1 3698816 R 410289 CDS YP_979474.1 121639250 4695604 complement(3699287..3700351) 1 NC_008769.1 Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv; molybdenum cofactor biosynthesis protein A moaA1 3700351 moaA3 4695604 moaA3 Mycobacterium bovis BCG str. Pasteur 1173P2 molybdenum cofactor biosynthesis protein A moaA1 YP_979474.1 3699287 R 410289 CDS YP_979475.1 121639251 4698508 3700406..3700756 1 NC_008769.1 Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv but present in CDC1551 (CDS not annotated); hypothetical protein 3700756 4698508 BCG_3393 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979475.1 3700406 D 410289 CDS YP_979476.1 121639252 4698599 3700734..3701120 1 NC_008769.1 Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv but present in CDC1551 (CDS not annotated); hypothetical protein 3701120 4698599 BCG_3394 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979476.1 3700734 D 410289 CDS YP_979477.1 121639253 4699240 3700996..3702141 1 NC_008769.1 Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv; transcriptional regulatory protein embR2 3702141 embR2 4699240 embR2 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein embR2 YP_979477.1 3700996 D 410289 CDS YP_979478.1 121639254 4697917 complement(3702236..3702880) 1 NC_008769.1 Belongs to the RvD5 region. Absent from Mycobacterium tuberculosis strain H37Rv; hypothetical protein 3702880 4697917 BCG_3396c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979478.1 3702236 R 410289 CDS YP_979479.1 121639255 4698172 3703047..3704759 1 NC_008769.1 transposase fusion protein 3704759 4698172 BCG_3397 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase fusion protein YP_979479.1 3703047 D 410289 CDS YP_979480.1 121639256 4698147 complement(3704692..3705630) 1 NC_008769.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigJ 3705630 sigJ 4698147 sigJ Mycobacterium bovis BCG str. Pasteur 1173P2 RNA polymerase sigma factor SigJ YP_979480.1 3704692 R 410289 CDS YP_979481.1 121639257 4695358 3705690..3707006 1 NC_008769.1 Differs from Rv3329 by 1aa, H122Q; hypothetical protein 3707006 4695358 BCG_3399 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979481.1 3705690 D 410289 CDS YP_979482.1 121639258 4698538 3707075..3708292 1 NC_008769.1 penicillin-binding protein dacB1 3708292 dacB1 4698538 dacB1 Mycobacterium bovis BCG str. Pasteur 1173P2 penicillin-binding protein dacB1 YP_979482.1 3707075 D 410289 CDS YP_979483.1 121639259 4698666 3708388..3709881 1 NC_008769.1 Differs from Mb3364 by 5aa in-frame deletion at position 465, and from Rv3331 by same deletion and 1aa, L423P; sugar-transport integral membrane protein sugI 3709881 sugI 4698666 sugI Mycobacterium bovis BCG str. Pasteur 1173P2 sugar-transport integral membrane protein sugI YP_979483.1 3708388 D 410289 CDS YP_979484.1 121639260 4696335 3709878..3711029 1 NC_008769.1 N-acetylglucosamine-6-phosphate deacetylase nagA 3711029 nagA 4696335 nagA Mycobacterium bovis BCG str. Pasteur 1173P2 N-acetylglucosamine-6-phosphate deacetylase nagA YP_979484.1 3709878 D 410289 CDS YP_979485.1 121639261 4696617 complement(3711220..3712065) 1 NC_008769.1 hypothetical protein 3712065 4696617 BCG_3403c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979485.1 3711220 R 410289 CDS YP_979486.1 121639262 4699100 3712210..3712521 1 NC_008769.1 hypothetical protein 3712521 4699100 BCG_3404 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979486.1 3712210 D 410289 CDS YP_979487.1 121639263 4698244 3712540..3712980 1 NC_008769.1 MerR family transcriptional regulator 3712980 4698244 BCG_3405 Mycobacterium bovis BCG str. Pasteur 1173P2 MerR family transcriptional regulator YP_979487.1 3712540 D 410289 CDS YP_979488.1 121639264 4698618 complement(3713014..3713883) 1 NC_008769.1 Differs from Rv3335c and Mb3368c by 1aa, V86A; integral membrane protein 3713883 4698618 BCG_3406c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_979488.1 3713014 R 410289 CDS YP_979489.1 121639265 4699067 complement(3713904..3714914) 1 NC_008769.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 3714914 trpS 4699067 trpS Mycobacterium bovis BCG str. Pasteur 1173P2 tryptophanyl-tRNA synthetase YP_979489.1 3713904 R 410289 CDS YP_979490.1 121639266 4695830 3714939..3715832 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv3337 and Rv3338 exist as 2 genes with an overlap region between them. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-t) leads to a single product; hypothetical protein 3715832 4695830 BCG_3408 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979490.1 3714939 D 410289 CDS YP_979491.1 121639267 4699019 complement(3715899..3717128) 1 NC_008769.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 3717128 icd1 4699019 icd1 Mycobacterium bovis BCG str. Pasteur 1173P2 isocitrate dehydrogenase YP_979491.1 3715899 R 410289 CDS YP_979492.1 121639268 4699213 3717411..3718760 1 NC_008769.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; O-acetylhomoserine aminocarboxypropyltransferase 3718760 metC 4699213 metC Mycobacterium bovis BCG str. Pasteur 1173P2 O-acetylhomoserine aminocarboxypropyltransferase YP_979492.1 3717411 D 410289 CDS YP_979493.1 121639269 4698210 3718772..3719911 1 NC_008769.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase 3719911 metX 4698210 metX Mycobacterium bovis BCG str. Pasteur 1173P2 homoserine O-acetyltransferase YP_979493.1 3718772 D 410289 CDS YP_979494.1 121639270 4698208 3719908..3720639 1 NC_008769.1 methyltransferase 3720639 4698208 BCG_3412 Mycobacterium bovis BCG str. Pasteur 1173P2 methyltransferase YP_979494.1 3719908 D 410289 CDS YP_979495.1 121639271 4698272 complement(3720648..3724664) 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 3555 bp in-frame deletion (RD19) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Mb3375c by 1aa A514V and from Rv3343c by several transitions; PPE family protein 3724664 PPE54 4698272 PPE54 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979495.1 3720648 R 410289 CDS YP_979496.1 121639272 4697663 complement(3724713..3730343) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS50 and PE_PGRS49 exists as a single gene. In Mycobacterium bovis, a single base deletion (g-*) splits PE_PGRS50 into 2 parts, PE_PGRS50a and PE_PGRS50b and a single base deletion (c-*) leads to PE_PGRS49 and PE_PGRS50b existing as a single product. In Mycobacterium bovis BCG Pasteur, the first deletion is absent leading to an uniq single gene comprising PE_PGRS50 and PE_PGRS49; hypothetical protein 3730343 PE_PGRS50 4697663 PE_PGRS50 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979496.1 3724713 R 410289 CDS YP_979497.1 121639273 4695719 complement(3730767..3731024) 1 NC_008769.1 hypothetical protein 3731024 4695719 BCG_3415c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979497.1 3730767 R 410289 CDS YP_979498.1 121639274 4697665 complement(3734462..3740752) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PPE55 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits PPE55 into 2 parts, PPE55a and PPE55b. Differs from Rv3347c by many aa substitutions and from Mb3380c by 1 aa, P1089S; PPE family protein 3740752 PPE55a 4697665 PPE55a Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979498.1 3734462 R 410289 CDS YP_979499.1 121639275 4697664 3741332..3741823 1 NC_008769.1 transposase 3741823 4697664 BCG_3418 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979499.1 3741332 D 410289 CDS YP_979500.1 121639276 4698610 complement(3741860..3742600) 1 NC_008769.1 transposase 3742600 4698610 BCG_3419c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979500.1 3741860 R 410289 CDS YP_979501.1 121639277 4697667 complement(3753359..3754657) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, PPE56 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, 2 frameshifts due to single base transversion (c-a) and a single base deletion (g-*) splits PPE56 into 3 parts, PPE56a, PPE56b and PPE56d; Differs from Rv3350c and Mb3385c by 2aa deletion at position 291; PPE family protein 3754657 PPE56a 4697667 PPE56a Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979501.1 3753359 R 410289 CDS YP_979502.1 121639278 4697666 complement(3754901..3755695) 1 NC_008769.1 hypothetical protein 3755695 4697666 BCG_3423c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979502.1 3754901 R 410289 CDS YP_979503.1 121639279 4699137 complement(3755777..3756148) 1 NC_008769.1 oxidoreductase 3756148 4699137 BCG_3424c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979503.1 3755777 R 410289 CDS YP_979504.1 121639280 4699343 complement(3756291..3756551) 1 NC_008769.1 hypothetical protein 3756551 4699343 BCG_3425c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979504.1 3756291 R 410289 CDS YP_979505.1 121639281 4699209 3756666..3757055 1 NC_008769.1 Differs from Rv3354 by 1aa, A112V; hypothetical protein 3757055 4699209 BCG_3426 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979505.1 3756666 D 410289 CDS YP_979506.1 121639282 4699021 complement(3757069..3757362) 1 NC_008769.1 hypothetical protein 3757362 4699021 BCG_3427c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979506.1 3757069 R 410289 CDS YP_979507.1 121639283 4698595 complement(3757359..3758204) 1 NC_008769.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 3758204 folD 4698595 folD Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_979507.1 3757359 R 410289 CDS YP_979508.1 121639284 4697988 3758328..3758603 1 NC_008769.1 hypothetical protein 3758603 4697988 BCG_3429 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979508.1 3758328 D 410289 CDS YP_979509.1 121639285 4698990 3758600..3758857 1 NC_008769.1 hypothetical protein 3758857 4698990 BCG_3430 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979509.1 3758600 D 410289 CDS YP_979510.1 121639286 4698498 3758899..3760089 1 NC_008769.1 oxidoreductase 3760089 4698498 BCG_3431 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979510.1 3758899 D 410289 CDS YP_979511.1 121639287 4698153 3760206..3760574 1 NC_008769.1 hypothetical protein 3760574 4698153 BCG_3432 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979511.1 3760206 D 410289 CDS YP_979512.1 121639288 4698865 complement(3760571..3761122) 1 NC_008769.1 hypothetical protein 3761122 4698865 BCG_3433c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979512.1 3760571 R 410289 CDS YP_979513.1 121639289 4698994 complement(3761129..3761710) 1 NC_008769.1 ATP/GTP-binding protein 3761710 4698994 BCG_3434c Mycobacterium bovis BCG str. Pasteur 1173P2 ATP/GTP-binding protein YP_979513.1 3761129 R 410289 CDS YP_979514.1 121639290 4699196 complement(3761691..3762059) 1 NC_008769.1 hypothetical protein 3762059 4699196 BCG_3435c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979514.1 3761691 R 410289 CDS YP_979515.1 121639291 4699154 complement(3762037..3762429) 1 NC_008769.1 Differs from Rv3364c and Mb3399c, by 1aa, L22P; hypothetical protein 3762429 4699154 BCG_3436c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979515.1 3762037 R 410289 CDS YP_979516.1 121639292 4698130 complement(3762426..3765056) 1 NC_008769.1 hypothetical protein 3765056 4698130 BCG_3437c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979516.1 3762426 R 410289 CDS YP_979517.1 121639293 4698810 3765292..3765756 1 NC_008769.1 tRNA/rRNA methylase spoU 3765756 spoU 4698810 spoU Mycobacterium bovis BCG str. Pasteur 1173P2 tRNA/rRNA methylase spoU YP_979517.1 3765292 D 410289 CDS YP_979518.1 121639294 4695623 3766123..3767898 1 NC_008769.1 In Mycobacterium bovis, insertions of 105 bp and of 9 bp (*-ggcagcggt) lead to longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (626 aa versus 588 aa). In Mycobacterium bovis BCG Pasteur, there is no 105 bp insertion but the 9 bp insertion is present at codon 404. Differs also from Rv3367 by 1aa, S412G; PE-PGRS family protein 3767898 PE_PGRS51 4695623 PE_PGRS51 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_979518.1 3766123 D 410289 CDS YP_979519.1 121639295 4695720 complement(3767899..3768543) 1 NC_008769.1 oxidoreductase 3768543 4695720 BCG_3440c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979519.1 3767899 R 410289 CDS YP_979520.1 121639296 4698594 3768542..3768976 1 NC_008769.1 hypothetical protein 3768976 4698594 BCG_3441 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979520.1 3768542 D 410289 CDS YP_979521.1 121639297 4698238 complement(3769065..3772304) 1 NC_008769.1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase.; error-prone DNA polymerase 3772304 dnaE2 4698238 dnaE2 Mycobacterium bovis BCG str. Pasteur 1173P2 error-prone DNA polymerase YP_979521.1 3769065 R 410289 CDS YP_979522.1 121639298 4697937 3772496..3773836 1 NC_008769.1 Differs from Rv3371 by 2aa, G339R, V368I; hypothetical protein 3773836 4697937 BCG_3443 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979522.1 3772496 D 410289 CDS YP_979523.1 121639299 4698978 3773878..3775053 1 NC_008769.1 trehalose 6-phosphate phosphatase otsB2 3775053 otsB2 4698978 otsB2 Mycobacterium bovis BCG str. Pasteur 1173P2 trehalose 6-phosphate phosphatase otsB2 YP_979523.1 3773878 D 410289 CDS YP_979524.1 121639300 4698924 3775290..3776180 1 NC_008769.1 In Mycobacterium tuberculosis H37Rv, echA18 and echA18' exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transversion (t-g) leads to a single product; enoyl-CoA hydratase echA18 3776180 echA18 4698924 echA18 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase echA18 YP_979524.1 3775290 D 410289 CDS YP_979525.1 121639301 4697827 3776185..3777612 1 NC_008769.1 amidase amiD 3777612 amiD 4697827 amiD Mycobacterium bovis BCG str. Pasteur 1173P2 amidase amiD YP_979525.1 3776185 D 410289 CDS YP_979526.1 121639302 4697301 3777720..3778373 1 NC_008769.1 hypothetical protein 3778373 4697301 BCG_3447 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979526.1 3777720 D 410289 CDS YP_979527.1 121639303 4699095 complement(3778465..3779916) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a frameshift due to a 4 bp to 3 bp substitution (caat-aac) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; cyclase 3779916 4699095 BCG_3448c Mycobacterium bovis BCG str. Pasteur 1173P2 cyclase YP_979527.1 3778465 R 410289 CDS YP_979528.1 121639304 4698445 complement(3779921..3780811) 1 NC_008769.1 Differs from Rv3378c and Mb3412c by 1aa, A137V; hypothetical protein 3780811 4698445 BCG_3449c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979528.1 3779921 R 410289 CDS YP_979529.2 229576790 4699334 complement(3780820..3782658) 1 NC_008769.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 3782658 dxs2 4699334 dxs2 Mycobacterium bovis BCG str. Pasteur 1173P2 1-deoxy-D-xylulose-5-phosphate synthase YP_979529.2 3780820 R 410289 CDS YP_979530.1 121639306 4696508 complement(3782655..3783644) 1 NC_008769.1 lytB-related protein lytB1 3783644 lytB1 4696508 lytB1 Mycobacterium bovis BCG str. Pasteur 1173P2 lytB-related protein lytB1 YP_979530.1 3782655 R 410289 CDS YP_979531.1 121639307 4697180 complement(3783644..3784696) 1 NC_008769.1 Differs from Rv3383c by 1aa, G132V; polyprenyl synthetase idsB 3784696 idsB 4697180 idsB Mycobacterium bovis BCG str. Pasteur 1173P2 polyprenyl synthetase idsB YP_979531.1 3783644 R 410289 CDS YP_979532.1 121639308 4696223 complement(3785450..3785842) 1 NC_008769.1 hypothetical protein 3785842 4696223 BCG_3453c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979532.1 3785450 R 410289 CDS YP_979533.1 121639309 4698563 complement(3785842..3786150) 1 NC_008769.1 hypothetical protein 3786150 4698563 BCG_3454c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979533.1 3785842 R 410289 CDS YP_979534.1 121639310 4698867 3786299..3787003 1 NC_008769.1 transposase 3787003 4698867 BCG_3455 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979534.1 3786299 D 410289 CDS YP_979535.1 121639311 4698917 3786993..3787670 1 NC_008769.1 transposase 3787670 4698917 BCG_3456 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979535.1 3786993 D 410289 CDS YP_979536.1 121639312 4699142 3787860..3790112 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, insertions of 60 bp and 78 bp, and deletions of 75 bp and 9 bp (cggcggcgc-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (750 aa and 749 aa versus 731 aa). Differs from Mb3420 by 1aa insertion, A205; PE-PGRS family protein 3790112 PE_PGRS52 4699142 PE_PGRS52 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_979536.1 3787860 D 410289 CDS YP_979537.1 121639313 4695721 complement(3790183..3791055) 1 NC_008769.1 Differs from Mb3421c by 1aa, P172L; dehydrogenase 3791055 4695721 BCG_3458c Mycobacterium bovis BCG str. Pasteur 1173P2 dehydrogenase YP_979537.1 3790183 R 410289 CDS YP_979538.1 121639314 4696628 3791129..3791839 1 NC_008769.1 lipoprotein lpqD 3791839 lpqD 4696628 lpqD Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqD YP_979538.1 3791129 D 410289 CDS YP_979539.1 121639315 4696107 3791885..3793837 1 NC_008769.1 short chain dehydrogenase 3793837 acrA1 4696107 acrA1 Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_979539.1 3791885 D 410289 CDS YP_979540.1 121639316 4696511 complement(3793838..3794701) 1 NC_008769.1 Differs from Rv3392c by 1aa, S112N; cyclopropane-fatty-acyl-phospholipid synthase 1 cmaA1 3794701 cmaA1 4696511 cmaA1 Mycobacterium bovis BCG str. Pasteur 1173P2 cyclopropane-fatty-acyl-phospholipid synthase 1 cmaA1 YP_979540.1 3793838 R 410289 CDS YP_979541.1 121639317 4698492 3794725..3795651 1 NC_008769.1 nucleoside hydrolase iunH 3795651 iunH 4698492 iunH Mycobacterium bovis BCG str. Pasteur 1173P2 nucleoside hydrolase iunH YP_979541.1 3794725 D 410289 CDS YP_979542.1 121639318 4697348 complement(3795706..3797289) 1 NC_008769.1 hypothetical protein 3797289 4697348 BCG_3463c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979542.1 3795706 R 410289 CDS YP_979543.1 121639319 4698491 complement(3797286..3797900) 1 NC_008769.1 Differs from Rv3395c by 2aa, V3A, M104V; hypothetical protein 3797900 4698491 BCG_3464c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979543.1 3797286 R 410289 CDS YP_979544.1 121639320 4699220 3797983..3798609 1 NC_008769.1 hypothetical protein 3798609 4699220 BCG_3465 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979544.1 3797983 D 410289 CDS YP_979545.1 121639321 4698540 complement(3798765..3800342) 1 NC_008769.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 3800342 guaA 4698540 guaA Mycobacterium bovis BCG str. Pasteur 1173P2 GMP synthase YP_979545.1 3798765 R 410289 CDS YP_979546.1 121639322 4697814 complement(3800354..3801262) 1 NC_008769.1 phytoene synthase phyA 3801262 phyA 4697814 phyA Mycobacterium bovis BCG str. Pasteur 1173P2 phytoene synthase phyA YP_979546.1 3800354 R 410289 CDS YP_979547.1 121639323 4697038 complement(3801291..3802370) 1 NC_008769.1 multifunctional geranylgeranyl pyrophosphate synthetase idsA1 3802370 idsA1 4697038 idsA1 Mycobacterium bovis BCG str. Pasteur 1173P2 multifunctional geranylgeranyl pyrophosphate synthetase idsA1 YP_979547.1 3801291 R 410289 CDS YP_979548.1 121639324 4696221 3802393..3803439 1 NC_008769.1 Differs from Rv3399 by 1aa, E330A; hypothetical protein 3803439 4696221 BCG_3469 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979548.1 3802393 D 410289 CDS YP_979549.1 121639325 4698786 3803503..3804291 1 NC_008769.1 hydrolase 3804291 4698786 BCG_3470 Mycobacterium bovis BCG str. Pasteur 1173P2 hydrolase YP_979549.1 3803503 D 410289 CDS YP_979550.1 121639326 4698382 3804306..3806666 1 NC_008769.1 Differs from Mb3434 by 1aa, R658H; hypothetical protein 3806666 4698382 BCG_3471 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979550.1 3804306 D 410289 CDS YP_979551.1 121639327 4698183 complement(3807341..3808393) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transversion (c-g) leads to a shorter product. Differs from Mb3436c by 1aa, R154C; hypothetical protein 3808393 4698183 BCG_3472c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979551.1 3807341 R 410289 CDS YP_979552.1 121639328 4698934 complement(3808764..3810365) 1 NC_008769.1 hypothetical protein 3810365 4698934 BCG_3473c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979552.1 3808764 R 410289 CDS YP_979553.1 121639329 4699012 complement(3810382..3811086) 1 NC_008769.1 hypothetical protein 3811086 4699012 BCG_3474c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979553.1 3810382 R 410289 CDS YP_979554.1 121639330 4698583 complement(3811204..3811770) 1 NC_008769.1 transcriptional regulatory protein 3811770 4698583 BCG_3475c Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_979554.1 3811204 R 410289 CDS YP_979555.1 121639331 4698010 3811832..3812719 1 NC_008769.1 dioxygenase 3812719 4698010 BCG_3476 Mycobacterium bovis BCG str. Pasteur 1173P2 dioxygenase YP_979555.1 3811832 D 410289 CDS YP_979556.1 121639332 4698519 3812754..3813053 1 NC_008769.1 hypothetical protein 3813053 4698519 BCG_3477 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979556.1 3812754 D 410289 CDS YP_979557.1 121639333 4698945 3813050..3813460 1 NC_008769.1 Differs from Rv3408 by 1aa, L46S; hypothetical protein 3813460 4698945 BCG_3478 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979557.1 3813050 D 410289 CDS YP_979558.1 121639334 4698864 complement(3813493..3815229) 1 NC_008769.1 cholesterol oxidase precursor choD 3815229 choD 4698864 choD Mycobacterium bovis BCG str. Pasteur 1173P2 cholesterol oxidase precursor choD YP_979558.1 3813493 R 410289 CDS YP_979559.1 121639335 4696697 complement(3815285..3816412) 1 NC_008769.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 3816412 guaB3 4696697 guaB3 Mycobacterium bovis BCG str. Pasteur 1173P2 inosine 5-monophosphate dehydrogenase YP_979559.1 3815285 R 410289 CDS YP_979560.1 121639336 4695439 complement(3816432..3818021) 1 NC_008769.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 3818021 guaB2 4695439 guaB2 Mycobacterium bovis BCG str. Pasteur 1173P2 inosine 5'-monophosphate dehydrogenase YP_979560.1 3816432 R 410289 CDS YP_979561.1 121639337 4697816 3818228..3818638 1 NC_008769.1 hypothetical protein 3818638 4697816 BCG_3482 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979561.1 3818228 D 410289 CDS YP_979562.1 121639338 4699273 complement(3818648..3819547) 1 NC_008769.1 hypothetical protein 3819547 4699273 BCG_3483c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979562.1 3818648 R 410289 CDS YP_979563.1 121639339 4698371 complement(3819540..3820178) 1 NC_008769.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase; RNA polymerase sigma factor SigD 3820178 sigD 4698371 sigD Mycobacterium bovis BCG str. Pasteur 1173P2 RNA polymerase sigma factor SigD YP_979563.1 3819540 R 410289 CDS YP_979564.1 121639340 4695816 complement(3820196..3821023) 1 NC_008769.1 hypothetical protein 3821023 4695816 BCG_3485c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979564.1 3820196 R 410289 CDS YP_979565.1 121639341 4695415 3821394..3821702 1 NC_008769.1 transcriptional regulatory protein whiB-like whib3 3821702 whiB3 4695415 whiB3 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein whiB-like whib3 YP_979565.1 3821394 D 410289 CDS YP_979566.1 121639342 4697342 complement(3821774..3823393) 1 NC_008769.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth; chaperonin GroEL 3823393 groEL 4697342 groEL Mycobacterium bovis BCG str. Pasteur 1173P2 chaperonin GroEL YP_979566.1 3821774 R 410289 CDS YP_979567.1 121639343 4698394 complement(3823488..3823790) 1 NC_008769.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 3823790 groES 4698394 groES Mycobacterium bovis BCG str. Pasteur 1173P2 co-chaperonin GroES YP_979567.1 3823488 R 410289 CDS YP_979568.1 121639344 4698396 complement(3824057..3825091) 1 NC_008769.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 3825091 gcp 4698396 gcp Mycobacterium bovis BCG str. Pasteur 1173P2 DNA-binding/iron metalloprotein/AP endonuclease YP_979568.1 3824057 R 410289 CDS YP_979569.1 121639345 4696529 complement(3825088..3825564) 1 NC_008769.1 ribosomal-protein-alanine acetyltransferase rimI 3825564 rimI 4696529 rimI Mycobacterium bovis BCG str. Pasteur 1173P2 ribosomal-protein-alanine acetyltransferase rimI YP_979569.1 3825088 R 410289 CDS YP_979570.1 121639346 4695904 complement(3825561..3826196) 1 NC_008769.1 hypothetical protein 3826196 4695904 BCG_3491c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979570.1 3825561 R 410289 CDS YP_979571.1 121639347 4698273 complement(3826193..3826699) 1 NC_008769.1 hypothetical protein 3826699 4698273 BCG_3492c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979571.1 3826193 R 410289 CDS YP_979572.1 121639348 4698550 complement(3826696..3827922) 1 NC_008769.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 3827922 alr 4698550 alr Mycobacterium bovis BCG str. Pasteur 1173P2 alanine racemase YP_979572.1 3826696 R 410289 CDS YP_979573.1 121639349 4698623 complement(3828216..3828578) 1 NC_008769.1 hypothetical protein 3828578 4698623 BCG_3494c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979573.1 3828216 R 410289 CDS YP_979574.1 121639350 4699327 3828741..3829277 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a large deletion of 4926 bp (RD6) leads to the loss of the COOH part of PPE57, and the following CDSs, PPE58, Rv3427c, Rv3428c and the NH2-part of PPE59 compared to Mycobacterium tuberculosis strain H37Rv; PPE family protein 3829277 PPE57 4699327 PPE57 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979574.1 3828741 D 410289 CDS YP_979575.1 121639351 4698214 complement(3829218..3830381) 1 NC_008769.1 Differs from Mb3460c by 1aa, R233H; transposase 3830381 4698214 BCG_3496c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979575.1 3829218 R 410289 CDS YP_979576.1 121639352 4698593 complement(3830870..3831715) 1 NC_008769.1 transposase 3831715 4698593 BCG_3497c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979576.1 3830870 R 410289 CDS YP_979577.1 121639353 4698524 complement(3831948..3833330) 1 NC_008769.1 glutamate decarboxylase gadB 3833330 gadB 4698524 gadB Mycobacterium bovis BCG str. Pasteur 1173P2 glutamate decarboxylase gadB YP_979577.1 3831948 R 410289 CDS YP_979578.1 121639354 4695552 complement(3833368..3834786) 1 NC_008769.1 Differs from Mb3463c by 1aa, A436 deleted, and from Rv3433c by 2aa, A436 deleted, A442S; hypothetical protein 3834786 4695552 BCG_3499c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979578.1 3833368 R 410289 CDS YP_979579.1 121639355 4698755 complement(3834788..3835501) 1 NC_008769.1 Differs from Mb3464c by 1aa, A193T; hypothetical protein 3835501 4698755 BCG_3500c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979579.1 3834788 R 410289 CDS YP_979580.1 121639356 4699135 complement(3835512..3836366) 1 NC_008769.1 hypothetical protein 3836366 4699135 BCG_3501c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979580.1 3835512 R 410289 CDS YP_979581.1 121639357 4698443 complement(3836588..3838462) 1 NC_008769.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 3838462 glmS 4698443 glmS Mycobacterium bovis BCG str. Pasteur 1173P2 glucosamine--fructose-6-phosphate aminotransferase YP_979581.1 3836588 R 410289 CDS YP_979582.1 121639358 4696645 3838484..3838960 1 NC_008769.1 Differs from Rv3437 by 1aa P84L; hypothetical protein 3838960 4696645 BCG_3503 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979582.1 3838484 D 410289 CDS YP_979583.1 121639359 4698812 3838970..3839812 1 NC_008769.1 hypothetical protein 3839812 4698812 BCG_3504 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979583.1 3838970 D 410289 CDS YP_979584.1 121639360 4698036 complement(3839832..3841235) 1 NC_008769.1 hypothetical protein 3841235 4698036 BCG_3505c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979584.1 3839832 R 410289 CDS YP_979585.1 121639361 4698754 complement(3841238..3841549) 1 NC_008769.1 hypothetical protein 3841549 4698754 BCG_3506c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979585.1 3841238 R 410289 CDS YP_979586.1 121639362 4697009 complement(3841597..3842943) 1 NC_008769.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 3842943 glmM 4697009 glmM Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoglucosamine mutase YP_979586.1 3841597 R 410289 CDS YP_979587.1 121639363 4698098 complement(3843068..3843523) 1 NC_008769.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 3843523 rpsI 4698098 rpsI Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S9 YP_979587.1 3843068 R 410289 CDS YP_979588.1 121639364 4695756 complement(3843520..3843963) 1 NC_008769.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 3843963 rplM 4695756 rplM Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L13 YP_979588.1 3843520 R 410289 CDS YP_979589.1 121639365 4695928 complement(3844196..3844498) 1 NC_008769.1 hypothetical protein 3844498 esxT 4695928 esxT Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979589.1 3844196 R 410289 CDS YP_979590.1 121639366 4695613 complement(3844519..3844896) 1 NC_008769.1 hypothetical protein 3844896 esxU 4695613 esxU Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979590.1 3844519 R 410289 CDS YP_979591.1 121639367 4696842 complement(3844889..3846103) 1 NC_008769.1 hypothetical protein 3846103 4696842 BCG_3512c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979591.1 3844889 R 410289 CDS YP_979592.1 121639368 4699031 complement(3846100..3849810) 1 NC_008769.1 Differs from Rv3444c by 1 aa, G1082S and Mb3477c by 1 aa G1159S; hypothetical protein 3849810 4699031 BCG_3513c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979592.1 3846100 R 410289 CDS YP_979593.1 121639369 4698388 3849924..3851327 1 NC_008769.1 Differs from Mb3478 by 1aa A265D; integral membrane protein 3851327 4698388 BCG_3514 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_979593.1 3849924 D 410289 CDS YP_979594.1 121639370 4699136 3851324..3852691 1 NC_008769.1 serine protease 3852691 4699136 BCG_3515 Mycobacterium bovis BCG str. Pasteur 1173P2 serine protease YP_979594.1 3851324 D 410289 CDS YP_979595.1 121639371 4698895 complement(3852656..3854068) 1 NC_008769.1 hypothetical protein 3854068 4698895 BCG_3516c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979595.1 3852656 R 410289 CDS YP_979596.1 121639372 4698969 3854189..3854974 1 NC_008769.1 Differs from Rv3451 and Mb3481 by deletion of 1aa, 262R; cutinase precursor cut3 3854974 cut3 4698969 cut3 Mycobacterium bovis BCG str. Pasteur 1173P2 cutinase precursor cut3 YP_979596.1 3854189 D 410289 CDS YP_979597.1 121639373 4695733 3855021..3855701 1 NC_008769.1 cutinase precursor cut4 3855701 cut4 4695733 cut4 Mycobacterium bovis BCG str. Pasteur 1173P2 cutinase precursor cut4 YP_979597.1 3855021 D 410289 CDS YP_979598.1 121639374 4695612 3855973..3857658 1 NC_008769.1 In Mycobacterium tuberculosis H37Rv, Rv3453 and Rv3454 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (t-*) results in a single product that is more similar to Rv3454. Differs from Mb3483 by 1aa, V328I; hypothetical protein 3857658 4695612 BCG_3519 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979598.1 3855973 D 410289 CDS YP_979599.1 121639375 4698408 complement(3857620..3858390) 1 NC_008769.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 3858390 truA 4698408 truA Mycobacterium bovis BCG str. Pasteur 1173P2 tRNA pseudouridine synthase A YP_979599.1 3857620 R 410289 CDS YP_979600.1 121639376 4695831 complement(3858458..3859000) 1 NC_008769.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 3859000 rplQ 4695831 rplQ Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L17 YP_979600.1 3858458 R 410289 CDS YP_979601.1 121639377 4695892 complement(3859032..3860075) 1 NC_008769.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 3860075 rpoA 4695892 rpoA Mycobacterium bovis BCG str. Pasteur 1173P2 DNA-directed RNA polymerase subunit alpha YP_979601.1 3859032 R 410289 CDS YP_979602.1 121639378 4696374 complement(3860226..3860831) 1 NC_008769.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 3860831 rpsD 4696374 rpsD Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S4 YP_979602.1 3860226 R 410289 CDS YP_979603.1 121639379 4697298 complement(3860840..3861259) 1 NC_008769.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 3861259 rpsK 4697298 rpsK Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S11 YP_979603.1 3860840 R 410289 CDS YP_979604.1 121639380 4695758 complement(3861263..3861637) 1 NC_008769.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 3861637 rpsM 4695758 rpsM Mycobacterium bovis BCG str. Pasteur 1173P2 30S ribosomal protein S13 YP_979604.1 3861263 R 410289 CDS YP_979605.1 121639381 4698850 complement(3861853..3861966) 1 NC_008769.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 3861966 rpmJ 4698850 rpmJ Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L36 YP_979605.1 3861853 R 410289 CDS YP_979606.1 121639382 4695801 complement(3861999..3862220) 1 NC_008769.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 3862220 infA 4695801 infA Mycobacterium bovis BCG str. Pasteur 1173P2 translation initiation factor IF-1 YP_979606.1 3861999 R 410289 CDS YP_979607.1 121639383 4698977 3862474..3863331 1 NC_008769.1 hypothetical protein 3863331 4698977 BCG_3528 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979607.1 3862474 D 410289 CDS YP_979608.1 121639384 4698485 3863404..3864399 1 NC_008769.1 dTDP-glucose 4,6-dehydratase rmlB1 3864399 rmlB1 4698485 rmlB1 Mycobacterium bovis BCG str. Pasteur 1173P2 dTDP-glucose 4,6-dehydratase rmlB1 YP_979608.1 3863404 D 410289 CDS YP_979609.1 121639385 4695584 3864401..3865009 1 NC_008769.1 dTDP-4-dehydrorhamnose 3,5-epimerase rmlC 3865009 rmlC 4695584 rmlC Mycobacterium bovis BCG str. Pasteur 1173P2 dTDP-4-dehydrorhamnose 3,5-epimerase rmlC YP_979609.1 3864401 D 410289 CDS YP_979610.1 121639386 4695586 3865092..3865760 1 NC_008769.1 Differs from Rv3466 by 4aa, T56A, T63A, L91R, I131V; hypothetical protein 3865760 4695586 BCG_3531 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979610.1 3865092 D 410289 CDS YP_979611.1 121639387 4698050 3865531..3866484 1 NC_008769.1 Differs from Rv3467 by 6aa, E134K, G245A, D262G, R275H, K276N, E315K; hypothetical protein 3866484 4698050 BCG_3532 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979611.1 3865531 D 410289 CDS YP_979612.1 121639388 4698265 complement(3866542..3867636) 1 NC_008769.1 Differs from Rv3468c by 1aa, V62I; dTDP-glucose 4,6-dehydratase rmlB2 3867636 rmlB2 4698265 rmlB2 Mycobacterium bovis BCG str. Pasteur 1173P2 dTDP-glucose 4,6-dehydratase rmlB2 YP_979612.1 3866542 R 410289 CDS YP_979613.1 121639389 4695585 complement(3867640..3868650) 1 NC_008769.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 3868650 mhpE 4695585 mhpE Mycobacterium bovis BCG str. Pasteur 1173P2 4-hydroxy-2-ketovalerate aldolase YP_979613.1 3867640 R 410289 CDS YP_979614.1 121639390 4699001 complement(3868711..3870369) 1 NC_008769.1 Differs from Mb3499c by 1aa, G421E; acetolactate synthase large subunit IlvB 3870369 ilvB2 4699001 ilvB2 Mycobacterium bovis BCG str. Pasteur 1173P2 acetolactate synthase large subunit IlvB YP_979614.1 3868711 R 410289 CDS YP_979615.1 121639391 4699339 complement(3870375..3870908) 1 NC_008769.1 Differs from Mb3500c by 1aa, C155W; hypothetical protein 3870908 4699339 BCG_3536c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979615.1 3870375 R 410289 CDS YP_979616.1 121639392 4698267 3870929..3871435 1 NC_008769.1 hypothetical protein 3871435 4698267 BCG_3537 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979616.1 3870929 D 410289 CDS YP_979617.1 121639393 4699324 complement(3871515..3872300) 1 NC_008769.1 peroxidase bpoA 3872300 bpoA 4699324 bpoA Mycobacterium bovis BCG str. Pasteur 1173P2 peroxidase bpoA YP_979617.1 3871515 R 410289 CDS YP_979618.1 121639394 4695553 complement(3872580..3873929) 1 NC_008769.1 Differs from Rv3476c by 2aa, F81L, V144A; dicarboxylic acid transport integral membrane protein kgtP 3873929 kgtP 4695553 kgtP Mycobacterium bovis BCG str. Pasteur 1173P2 dicarboxylic acid transport integral membrane protein kgtP YP_979618.1 3872580 R 410289 CDS YP_979619.1 121639395 4696456 3874302..3874598 1 NC_008769.1 Differs from Rv3477 by 1aa, A26V; PE family protein 3874598 PE31 4696456 PE31 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_979619.1 3874302 D 410289 CDS YP_979620.1 121639396 4698938 3874635..3875816 1 NC_008769.1 PE family protein 3875816 PPE60 4698938 PPE60 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_979620.1 3874635 D 410289 CDS YP_979621.1 121639397 4698216 3876029..3877330 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv3479 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 713 bp deletion(RD18) splits Rv3479 into 2 parts, Mb3507 and Mb3508. Differs from Rv3479 by 1aa, R174L; hypothetical protein 3877330 4698216 BCG_3542 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979621.1 3876029 D 410289 CDS YP_979622.1 121639398 4698775 3877335..3878381 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv3479 exists as a single gene. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a 713 bp deletion (RD18) splits Rv3479 into 2 parts, Mb3507 and Mb3508. Differs from Rv3479 by 1aa, N344T; hypothetical protein 3878381 4698775 BCG_3543 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979622.1 3877335 D 410289 CDS YP_979623.1 121639399 4698259 complement(3878405..3879898) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv3480c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (gt-*) splits Rv3480c into 2 parts, Mb3509c and Mb3510c. Differs from Rv3480c and Mb3510c by 1aa, N205D; hypothetical protein 3879898 4698259 BCG_3544c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979623.1 3878405 R 410289 CDS YP_979624.1 121639400 4698873 complement(3879989..3880678) 1 NC_008769.1 integral membrane protein 3880678 4698873 BCG_3545c Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_979624.1 3879989 R 410289 CDS YP_979625.1 121639401 4699160 complement(3880113..3881603) 1 NC_008769.1 BCG_3546c; In Mycobacterium bovis BCG Pasteur, a single base insertion (C) at position equivalent to Mycobacterium tuberculosis H37Rv position 3901442-3901443 leads to frameshift and longer product of 496 aa compared to Rv3482c, len: 260 aa; hypothetical protein 3881603 4699160 BCG_3546c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979625.1 3880113 R 410289 CDS YP_979626.1 121639402 4699022 complement(3881647..3882309) 1 NC_008769.1 hypothetical protein 3882309 4699022 BCG_3547c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979626.1 3881647 R 410289 CDS YP_979627.1 121639403 4698729 3882575..3884113 1 NC_008769.1 protein cpsA 3884113 cpsA 4698729 cpsA Mycobacterium bovis BCG str. Pasteur 1173P2 protein cpsA YP_979627.1 3882575 D 410289 CDS YP_979628.1 121639404 4697923 complement(3884119..3885063) 1 NC_008769.1 short chain dehydrogenase 3885063 4697923 BCG_3549c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_979628.1 3884119 R 410289 CDS YP_979629.1 121639405 4698513 3885269..3885718 1 NC_008769.1 hypothetical protein 3885718 4698513 BCG_3550 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979629.1 3885269 D 410289 CDS YP_979630.1 121639406 4698963 complement(3885671..3886504) 1 NC_008769.1 esterase/lipase lipF 3886504 lipF 4698963 lipF Mycobacterium bovis BCG str. Pasteur 1173P2 esterase/lipase lipF YP_979630.1 3885671 R 410289 CDS YP_979631.1 121639407 4698085 3887164..3887487 1 NC_008769.1 Differs from Rv3488 by 1aa, R98G; hypothetical protein 3887487 4698085 BCG_3552 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979631.1 3887164 D 410289 CDS YP_979632.1 121639408 4699245 3887569..3887733 1 NC_008769.1 hypothetical protein 3887733 4699245 BCG_3553 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979632.1 3887569 D 410289 CDS YP_979633.1 121639409 4698947 3887733..3889235 1 NC_008769.1 Differs from Rv3490 by 1aa, L334V; alpha, alpha-trehalose-phosphate synthase OtsA 3889235 otsA 4698947 otsA Mycobacterium bovis BCG str. Pasteur 1173P2 alpha, alpha-trehalose-phosphate synthase OtsA YP_979633.1 3887733 D 410289 CDS YP_979634.1 121639410 4698922 3889387..3889965 1 NC_008769.1 hypothetical protein 3889965 4698922 BCG_3555 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979634.1 3889387 D 410289 CDS YP_979635.1 121639411 4699090 complement(3889962..3890444) 1 NC_008769.1 Mce-associated protein 3890444 4699090 BCG_3556c Mycobacterium bovis BCG str. Pasteur 1173P2 Mce-associated protein YP_979635.1 3889962 R 410289 CDS YP_979636.1 121639412 4699292 complement(3890444..3891172) 1 NC_008769.1 Mce-associated protein 3891172 4699292 BCG_3557c Mycobacterium bovis BCG str. Pasteur 1173P2 Mce-associated protein YP_979636.1 3890444 R 410289 CDS YP_979637.1 121639413 4697965 complement(3891172..3892866) 1 NC_008769.1 Differs from Rv3494c by 1aa, G245D; Mce-family protein mce4F 3892866 mce4F 4697965 mce4F Mycobacterium bovis BCG str. Pasteur 1173P2 Mce-family protein mce4F YP_979637.1 3891172 R 410289 CDS YP_979638.1 121639414 4697638 complement(3892877..3894031) 1 NC_008769.1 mce family lipoprotein LprN 3894031 lprN 4697638 lprN Mycobacterium bovis BCG str. Pasteur 1173P2 mce family lipoprotein LprN YP_979638.1 3892877 R 410289 CDS YP_979639.1 121639415 4698590 complement(3894028..3895383) 1 NC_008769.1 Mce-family protein mce4D 3895383 mce4D 4698590 mce4D Mycobacterium bovis BCG str. Pasteur 1173P2 Mce-family protein mce4D YP_979639.1 3894028 R 410289 CDS YP_979640.1 121639416 4697637 complement(3895380..3896453) 1 NC_008769.1 Differs from Mb3527c and Rv3497c by 1aa, P46T; Mce-family protein mce4C 3896453 mce4C 4697637 mce4C Mycobacterium bovis BCG str. Pasteur 1173P2 Mce-family protein mce4C YP_979640.1 3895380 R 410289 CDS YP_979641.1 121639417 4697636 complement(3896443..3897495) 1 NC_008769.1 Mce-family protein mce4B 3897495 mce4B 4697636 mce4B Mycobacterium bovis BCG str. Pasteur 1173P2 Mce-family protein mce4B YP_979641.1 3896443 R 410289 CDS YP_979642.1 121639418 4697635 complement(3897495..3898697) 1 NC_008769.1 Mce-family protein mce4A 3898697 mce4A 4697635 mce4A Mycobacterium bovis BCG str. Pasteur 1173P2 Mce-family protein mce4A YP_979642.1 3897495 R 410289 CDS YP_979643.1 121639419 4695888 complement(3898717..3899559) 1 NC_008769.1 integral membrane protein YrbE4b 3899559 yrbE4B 4695888 yrbE4B Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YrbE4b YP_979643.1 3898717 R 410289 CDS YP_979644.1 121639420 4695515 complement(3899594..3900358) 1 NC_008769.1 integral membrane protein YrbE4a 3900358 yrbE4A 4695515 yrbE4A Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YrbE4a YP_979644.1 3899594 R 410289 CDS YP_979645.1 121639421 4695514 complement(3900584..3901537) 1 NC_008769.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 3901537 fabG 4695514 fabG Mycobacterium bovis BCG str. Pasteur 1173P2 3-ketoacyl-ACP reductase YP_979645.1 3900584 R 410289 CDS YP_979646.1 121639422 4699015 complement(3901562..3901753) 1 NC_008769.1 ferredoxin fdxD 3901753 fdxD 4699015 fdxD Mycobacterium bovis BCG str. Pasteur 1173P2 ferredoxin fdxD YP_979646.1 3901562 R 410289 CDS YP_979647.1 121639423 4695362 3901968..3903170 1 NC_008769.1 acyl-CoA dehydrogenase fadE26 3903170 fadE26 4695362 fadE26 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE26 YP_979647.1 3901968 D 410289 CDS YP_979648.1 121639424 4697414 3903195..3904316 1 NC_008769.1 Differs from Rv3505 by 1aa V218A; acyl-CoA dehydrogenase fadE27 3904316 fadE27 4697414 fadE27 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE27 YP_979648.1 3903195 D 410289 CDS YP_979649.1 121639425 4697415 3904387..3905895 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3905895 fadD17 4697415 fadD17 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_979649.1 3904387 D 410289 CDS YP_979650.1 121639426 4698964 3906066..3910184 1 NC_008769.1 In Mycobacterium bovis , insertions of 18 bp, 72 bp and 9 bp (*-cggcggcac), and deletions of 90 bp, 54 bp and 18 bp, and Mycobacterium bovis BCG Pasteur, insertions of 18 bp, 81 bp and 9 bp (*-cggcggcac), and deletions of 90 bp, 27 bp and 18 bp, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1360 aa and 1372 aa versus 1381 aa). Differs from Mb3537 by 2 insertions of 9aa and 3aa and by 1aa, N599D. Differs from Rv3507 by several insertions, deletions and by 2aa, N599D, G742D; PE-PGRS family protein 3910184 PE_PGRS53 4698964 PE_PGRS53 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_979650.1 3906066 D 410289 CDS YP_979651.1 121639427 4697028 3910475..3916759 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur several insertions lead to a longer product compared to its homolog in Mycobacterium bovis (2094 aa versus 1460 aa); PE-PGRS family protein 3916759 PE_PGRS54 4697028 PE_PGRS54 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_979651.1 3910475 D 410289 CDS YP_979652.1 121639428 4697029 complement(3916926..3918473) 1 NC_008769.1 thiamine-pyrophosphate requiring enzyme; hypothetical protein 3918473 ilvX 4697029 ilvX Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979652.1 3916926 R 410289 CDS YP_979653.1 121639429 4698975 complement(3918470..3919306) 1 NC_008769.1 hypothetical protein 3919306 4698975 BCG_3574c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979653.1 3918470 R 410289 CDS YP_979654.1 121639430 4698242 3919666..3925098 1 NC_008769.1 In Mycobacterium tuberculosis H37Rv, PE_PGRS55 and PE_PGRS56 exist as 2 genes. In Mycobacterium bovis, a 344 bp insertion results in a single product which is more similar to PE_PGRS55. In Mycobacterium bovis BCG Pasteur two deletions of 138bp and 246 bp lead to a shorter product compared to its homolog Mycobacterium bovis (1810 aa versus 1938 aa). Also differs from Mb3541 by 3aa, D628A, D743A and D857A; PE-PGRS family protein 3925098 PE_PGRS55 4698242 PE_PGRS55 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_979654.1 3919666 D 410289 CDS YP_979655.1 121639431 4697030 complement(3925227..3925883) 1 NC_008769.1 fatty-acid-CoA ligase fadD18 3925883 fadD18 4697030 fadD18 Mycobacterium bovis BCG str. Pasteur 1173P2 fatty-acid-CoA ligase fadD18 YP_979655.1 3925227 R 410289 CDS YP_979656.1 121639432 4698983 3925929..3929156 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur a deletion of 111 bp and an insertion of 360 bp lead to a longer product compared to its homolog Mycobacterium bovis. Also differs from Mb3543 by 2aa, S80L and T93A; PE-PGRS family protein 3929156 PE_PGRS57 4698983 PE_PGRS57 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_979656.1 3925929 D 410289 CDS YP_979657.1 121639433 4697031 complement(3929717..3931363) 1 NC_008769.1 activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence; acyl-CoA synthetase 3931363 fadD19 4697031 fadD19 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_979657.1 3929717 R 410289 CDS YP_979658.1 121639434 4698641 3931437..3932228 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 3932228 echA19 4698641 echA19 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_979658.1 3931437 D 410289 CDS YP_979659.1 121639435 4696809 3932324..3933163 1 NC_008769.1 hypothetical protein 3933163 4696809 BCG_3580 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979659.1 3932324 D 410289 CDS YP_979660.1 121639436 4698671 complement(3933218..3933799) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, cyp142 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (c-*) splits cyp142 into 2 parts, cyp142a and cyp142b; cytochrome P450 monooxygenase 142 cyp142b 3933799 cyp142b 4698671 cyp142b Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome P450 monooxygenase 142 cyp142b YP_979660.1 3933218 R 410289 CDS YP_979661.1 121639437 4695561 complement(3933796..3934413) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, cyp142 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (c-*) splits cyp142 into 2 parts, cyp142a and cyp142b; cytochrome P450 monooxygenase 142 cyp142a 3934413 cyp142a 4695561 cyp142a Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome P450 monooxygenase 142 cyp142a YP_979661.1 3933796 R 410289 CDS YP_979662.1 121639438 4695545 3934442..3935152 1 NC_008769.1 hypothetical protein 3935152 4695545 BCG_3583 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979662.1 3934442 D 410289 CDS YP_979663.1 121639439 4698198 complement(3935217..3936260) 1 NC_008769.1 coenzyme F420-dependent oxidoreductase 3936260 4698198 BCG_3584c Mycobacterium bovis BCG str. Pasteur 1173P2 coenzyme F420-dependent oxidoreductase YP_979663.1 3935217 R 410289 CDS YP_979664.1 121639440 4698413 3936413..3937324 1 NC_008769.1 Differs from Rv3521 by 1aa D295N; hypothetical protein 3937324 4698413 BCG_3585 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979664.1 3936413 D 410289 CDS YP_979665.1 121639441 4698503 3937340..3938404 1 NC_008769.1 Differs from Rv3522 by 1aa I324T; lipid-transfer protein 3938404 4698503 BCG_3586 Mycobacterium bovis BCG str. Pasteur 1173P2 lipid-transfer protein YP_979665.1 3937340 D 410289 CDS YP_979666.1 121639442 4698854 3938421..3939605 1 NC_008769.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 3939605 4698854 BCG_3587 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-CoA acetyltransferase YP_979666.1 3938421 D 410289 CDS YP_979667.1 121639443 4698842 3939647..3940678 1 NC_008769.1 hypothetical protein 3940678 4698842 BCG_3588 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979667.1 3939647 D 410289 CDS YP_979668.1 121639444 4699264 complement(3940692..3941216) 1 NC_008769.1 siderophore-binding protein 3941216 4699264 BCG_3589c Mycobacterium bovis BCG str. Pasteur 1173P2 siderophore-binding protein YP_979668.1 3940692 R 410289 CDS YP_979669.1 121639445 4698325 3941331..3942491 1 NC_008769.1 oxidoreductase 3942491 4698325 BCG_3590 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979669.1 3941331 D 410289 CDS YP_979670.1 121639446 4698329 3942497..3942946 1 NC_008769.1 hypothetical protein 3942946 4698329 BCG_3591 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979670.1 3942497 D 410289 CDS YP_979671.1 121639447 4699014 complement(3943371..3944084) 1 NC_008769.1 hypothetical protein 3944084 4699014 BCG_3592c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979671.1 3943371 R 410289 CDS YP_979672.1 121639448 4698891 complement(3944776..3945930) 1 NC_008769.1 hypothetical protein 3945930 4698891 BCG_3593c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979672.1 3944776 R 410289 CDS YP_979673.1 121639449 4699099 complement(3945930..3946712) 1 NC_008769.1 short chain dehydrogenase 3946712 4699099 BCG_3594c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_979673.1 3945930 R 410289 CDS YP_979674.1 121639450 4698240 complement(3946709..3947836) 1 NC_008769.1 hypothetical protein 3947836 4698240 BCG_3595c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979674.1 3946709 R 410289 CDS YP_979675.1 121639451 4699097 3948235..3949455 1 NC_008769.1 PPE family protein 3949455 PPE61 4699097 PPE61 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979675.1 3948235 D 410289 CDS YP_979676.1 121639452 4698217 complement(3949597..3951345) 1 NC_008769.1 PPE family protein 3951345 PPE62 4698217 PPE62 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979676.1 3949597 R 410289 CDS YP_979677.1 121639453 4697696 complement(3951444..3952484) 1 NC_008769.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 3952484 4697696 BCG_3598c Mycobacterium bovis BCG str. Pasteur 1173P2 4-hydroxy-2-ketovalerate aldolase YP_979677.1 3951444 R 410289 CDS YP_979678.1 121639454 4699101 complement(3952481..3953392) 1 NC_008769.1 catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 3953392 4699101 BCG_3599c Mycobacterium bovis BCG str. Pasteur 1173P2 acetaldehyde dehydrogenase YP_979678.1 3952481 R 410289 CDS YP_979679.1 121639455 4698760 complement(3953403..3954188) 1 NC_008769.1 hydratase 3954188 4698760 BCG_3600c Mycobacterium bovis BCG str. Pasteur 1173P2 hydratase YP_979679.1 3953403 R 410289 CDS YP_979680.1 121639456 4698453 3954261..3955952 1 NC_008769.1 initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione; 3-ketosteroid-delta-1-dehydrogenase 3955952 4698453 BCG_3601 Mycobacterium bovis BCG str. Pasteur 1173P2 3-ketosteroid-delta-1-dehydrogenase YP_979680.1 3954261 D 410289 CDS YP_979681.1 121639457 4698846 3955954..3956814 1 NC_008769.1 dehydrogenase 3956814 4698846 BCG_3602 Mycobacterium bovis BCG str. Pasteur 1173P2 dehydrogenase YP_979681.1 3955954 D 410289 CDS YP_979682.1 121639458 4698778 3956951..3958390 1 NC_008769.1 PPE family protein 3958390 PPE63 4698778 PPE63 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979682.1 3956951 D 410289 CDS YP_979683.1 121639459 4697697 complement(3958391..3959551) 1 NC_008769.1 lipid-transfer protein 3959551 ltp2 4697697 ltp2 Mycobacterium bovis BCG str. Pasteur 1173P2 lipid-transfer protein YP_979683.1 3958391 R 410289 CDS YP_979684.1 121639460 4697176 complement(3959551..3959940) 1 NC_008769.1 hypothetical protein 3959940 4697176 BCG_3605c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979684.1 3959551 R 410289 CDS YP_979685.1 121639461 4698171 complement(3959937..3960872) 1 NC_008769.1 hypothetical protein 3960872 4698171 BCG_3606c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979685.1 3959937 R 410289 CDS YP_979686.1 121639462 4698558 complement(3960869..3962032) 1 NC_008769.1 acyl-CoA dehydrogenase fadE29 3962032 fadE29 4698558 fadE29 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE29 YP_979686.1 3960869 R 410289 CDS YP_979687.1 121639463 4697578 complement(3962017..3963036) 1 NC_008769.1 acyl-CoA dehydrogenase fadE28 3963036 fadE28 4697578 fadE28 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE28 YP_979687.1 3962017 R 410289 CDS YP_979688.1 121639464 4697577 complement(3963036..3964337) 1 NC_008769.1 cytochrome P450 125 cyp125 3964337 cyp125 4697577 cyp125 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome P450 125 cyp125 YP_979688.1 3963036 R 410289 CDS YP_979689.1 121639465 4696436 3964449..3965624 1 NC_008769.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 3965624 fadA5 4696436 fadA5 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-CoA acetyltransferase YP_979689.1 3964449 D 410289 CDS YP_979690.1 121639466 4699134 3965736..3966191 1 NC_008769.1 hypothetical protein 3966191 4699134 BCG_3611 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979690.1 3965736 D 410289 CDS YP_979691.1 121639467 4699314 complement(3966274..3967188) 1 NC_008769.1 Differs from Rv3548c by 1aa V218M; short chain dehydrogenase 3967188 4699314 BCG_3612c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_979691.1 3966274 R 410289 CDS YP_979692.1 121639468 4699221 complement(3967211..3967990) 1 NC_008769.1 short chain dehydrogenase 3967990 4699221 BCG_3613c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_979692.1 3967211 R 410289 CDS YP_979693.1 121639469 4698274 3968045..3968788 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 3968788 echA20 4698274 echA20 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_979693.1 3968045 D 410289 CDS YP_979694.1 121639470 4697920 3968788..3969666 1 NC_008769.1 Differs from Rv3551 by 1aa, S7A; CoA-transferase subunit alpha 3969666 4697920 BCG_3615 Mycobacterium bovis BCG str. Pasteur 1173P2 CoA-transferase subunit alpha YP_979694.1 3968788 D 410289 CDS YP_979695.1 121639471 4699075 3969663..3970415 1 NC_008769.1 CoA-transferase subunit beta 3970415 4699075 BCG_3616 Mycobacterium bovis BCG str. Pasteur 1173P2 CoA-transferase subunit beta YP_979695.1 3969663 D 410289 CDS YP_979696.1 121639472 4698257 3970513..3971580 1 NC_008769.1 oxidoreductase 3971580 4698257 BCG_3617 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979696.1 3970513 D 410289 CDS YP_979697.1 121639473 4699085 3971577..3973634 1 NC_008769.1 electron transfer protein fdxB 3973634 fdxB 4699085 fdxB Mycobacterium bovis BCG str. Pasteur 1173P2 electron transfer protein fdxB YP_979697.1 3971577 D 410289 CDS YP_979698.1 121639474 4695360 complement(3973722..3974591) 1 NC_008769.1 Differs from Rv3555c by 1aa R268W; hypothetical protein 3974591 4695360 BCG_3619c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979698.1 3973722 R 410289 CDS YP_979699.1 121639475 4696146 complement(3974696..3975856) 1 NC_008769.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 3975856 fadA6 4696146 fadA6 Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-CoA acetyltransferase YP_979699.1 3974696 R 410289 CDS YP_979700.1 121639476 4696708 complement(3975921..3976523) 1 NC_008769.1 TetR family transcriptional regulator 3976523 4696708 BCG_3621c Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_979700.1 3975921 R 410289 CDS YP_979701.1 121639477 4698861 3976872..3978530 1 NC_008769.1 PPE family protein 3978530 PPE64 4698861 PPE64 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_979701.1 3976872 D 410289 CDS YP_979702.1 121639478 4697698 complement(3978539..3979327) 1 NC_008769.1 Differs from Rv3559c by 1aa V222A; short chain dehydrogenase 3979327 4697698 BCG_3623c Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_979702.1 3978539 R 410289 CDS YP_979703.1 121639479 4698011 complement(3979324..3980481) 1 NC_008769.1 acyl-CoA dehydrogenase fadE30 3980481 fadE30 4698011 fadE30 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE30 YP_979703.1 3979324 R 410289 CDS YP_979704.1 121639480 4697580 3980529..3982052 1 NC_008769.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 3982052 fadD3 4697580 fadD3 Mycobacterium bovis BCG str. Pasteur 1173P2 long-chain-fatty-acid--CoA ligase YP_979704.1 3980529 D 410289 CDS YP_979705.1 121639481 4699011 3982053..3983186 1 NC_008769.1 acyl-CoA dehydrogenase fadE31 3983186 fadE31 4699011 fadE31 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE31 YP_979705.1 3982053 D 410289 CDS YP_979706.1 121639482 4697581 3983183..3984142 1 NC_008769.1 Differs from Rv3563 by 2aa R105Q and S275W; acyl-CoA dehydrogenase fadE32 3984142 fadE32 4697581 fadE32 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE32 YP_979706.1 3983183 D 410289 CDS YP_979707.1 121639483 4695631 3984139..3985095 1 NC_008769.1 acyl-CoA dehydrogenase fadE33 3985095 fadE33 4695631 fadE33 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE33 YP_979707.1 3984139 D 410289 CDS YP_979708.1 121639484 4695632 3985092..3986258 1 NC_008769.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 3986258 aspB 4695632 aspB Mycobacterium bovis BCG str. Pasteur 1173P2 aspartate aminotransferase YP_979708.1 3985092 D 410289 CDS YP_979709.1 121639485 4695836 complement(3986223..3987074) 1 NC_008769.1 arylamine n-acetyltransferase nat 3987074 nat 4695836 nat Mycobacterium bovis BCG str. Pasteur 1173P2 arylamine n-acetyltransferase nat YP_979709.1 3986223 R 410289 CDS YP_979710.1 121639486 4696136 complement(3987059..3987325) 1 NC_008769.1 hypothetical protein 3987325 4696136 BCG_3631c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979710.1 3987059 R 410289 CDS YP_979711.1 121639487 4699092 complement(3987611..3988174) 1 NC_008769.1 Differs from Rv3567c by 1aa T179I; oxidoreductase 3988174 4699092 BCG_3632c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979711.1 3987611 R 410289 CDS YP_979712.1 121639488 4699277 complement(3988189..3989091) 1 NC_008769.1 Differs from Mb3599c by 1aa Q177R; biphenyl-2,3-diol 1,2-dioxygenase bphC 3989091 bphC 4699277 bphC Mycobacterium bovis BCG str. Pasteur 1173P2 biphenyl-2,3-diol 1,2-dioxygenase bphC YP_979712.1 3988189 R 410289 CDS YP_979713.1 121639489 4697051 complement(3989088..3989963) 1 NC_008769.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase 3989963 bphD 4697051 bphD Mycobacterium bovis BCG str. Pasteur 1173P2 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase YP_979713.1 3989088 R 410289 CDS YP_979714.1 121639490 4697113 complement(3989978..3991162) 1 NC_008769.1 Differs from Rv3570c by 1aa D18N; oxidoreductase 3991162 4697113 BCG_3635c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979714.1 3989978 R 410289 CDS YP_979715.1 121639491 4698586 3991309..3992385 1 NC_008769.1 hemoglobine-related protein hmp 3992385 hmp 4698586 hmp Mycobacterium bovis BCG str. Pasteur 1173P2 hemoglobine-related protein hmp YP_979715.1 3991309 D 410289 CDS YP_979716.1 121639492 4696100 3992403..3992933 1 NC_008769.1 hypothetical protein 3992933 4696100 BCG_3637 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979716.1 3992403 D 410289 CDS YP_979717.1 121639493 4698233 complement(3992969..3995104) 1 NC_008769.1 acyl-CoA dehydrogenase fadE34 3995104 fadE34 4698233 fadE34 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE34 YP_979717.1 3992969 R 410289 CDS YP_979718.1 121639494 4695633 3995376..3995975 1 NC_008769.1 TetR family transcriptional regulator 3995975 4695633 BCG_3639 Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_979718.1 3995376 D 410289 CDS YP_979719.1 121639495 4699230 complement(3995981..3997060) 1 NC_008769.1 LacI family transcriptional regulator 3997060 4699230 BCG_3640c Mycobacterium bovis BCG str. Pasteur 1173P2 LacI family transcriptional regulator YP_979719.1 3995981 R 410289 CDS YP_979720.1 121639496 4698792 3997250..3997963 1 NC_008769.1 Differs from Rv3576 by 1aa N118D; lipoprotein lppH 3997963 lppH 4698792 lppH Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lppH YP_979720.1 3997250 D 410289 CDS YP_979721.1 121639497 4696497 3998154..3999020 1 NC_008769.1 hypothetical protein 3999020 4696497 BCG_3642 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979721.1 3998154 D 410289 CDS YP_979722.1 121639498 4698279 3999034..4000275 1 NC_008769.1 Differs from Rv3578 by 1aa S319A; arsenical pump integral membrane protein arsB2 4000275 arsB2 4698279 arsB2 Mycobacterium bovis BCG str. Pasteur 1173P2 arsenical pump integral membrane protein arsB2 YP_979722.1 3999034 D 410289 CDS YP_979723.1 121639499 4695813 complement(4000317..4001285) 1 NC_008769.1 Differs from Rv3579c by 1aa, A302E. Mb3610c is longer due to frameshift and differs by 1aa V178M; tRNA/rRNA methyltransferase 4001285 4695813 BCG_3644c Mycobacterium bovis BCG str. Pasteur 1173P2 tRNA/rRNA methyltransferase YP_979723.1 4000317 R 410289 CDS YP_979724.1 121639500 4699126 complement(4001286..4002695) 1 NC_008769.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 4002695 cysS 4699126 cysS Mycobacterium bovis BCG str. Pasteur 1173P2 cysteinyl-tRNA synthetase YP_979724.1 4001286 R 410289 CDS YP_979725.1 121639501 4696145 complement(4002760..4003239) 1 NC_008769.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4003239 ispF 4696145 ispF Mycobacterium bovis BCG str. Pasteur 1173P2 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_979725.1 4002760 R 410289 CDS YP_979726.1 121639502 4697347 complement(4003236..4003931) 1 NC_008769.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 4003931 ispD 4697347 ispD Mycobacterium bovis BCG str. Pasteur 1173P2 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_979726.1 4003236 R 410289 CDS YP_979727.1 121639503 4697435 complement(4003948..4004436) 1 NC_008769.1 transcription factor 4004436 4697435 BCG_3648c Mycobacterium bovis BCG str. Pasteur 1173P2 transcription factor YP_979727.1 4003948 R 410289 CDS YP_979728.1 121639504 4699218 4004721..4005269 1 NC_008769.1 lipoprotein lpqE 4005269 lpqE 4699218 lpqE Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqE YP_979728.1 4004721 D 410289 CDS YP_979729.1 121639505 4696108 4005335..4006777 1 NC_008769.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 4006777 radA 4696108 radA Mycobacterium bovis BCG str. Pasteur 1173P2 DNA repair protein RadA YP_979729.1 4005335 D 410289 CDS YP_979730.1 121639506 4695436 4006782..4007858 1 NC_008769.1 non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair; DNA integrity scanning protein DisA 4007858 4695436 BCG_3651 Mycobacterium bovis BCG str. Pasteur 1173P2 DNA integrity scanning protein DisA YP_979730.1 4006782 D 410289 CDS YP_979731.1 121639507 4698218 complement(4007859..4008650) 1 NC_008769.1 Shorter than Rv3587c and Mb3618c by 1aa, P at 240; hypothetical protein 4008650 4698218 BCG_3652c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979731.1 4007859 R 410289 CDS YP_979732.1 121639508 4698358 complement(4008759..4009382) 1 NC_008769.1 Differs from Mb3619c by 1aa I79T; carbonic anhydrase 4009382 canB 4698358 canB Mycobacterium bovis BCG str. Pasteur 1173P2 carbonic anhydrase YP_979732.1 4008759 R 410289 CDS YP_979733.1 121639509 4695777 4009381..4010295 1 NC_008769.1 adenine glycosylase 4010295 mutY 4695777 mutY Mycobacterium bovis BCG str. Pasteur 1173P2 adenine glycosylase YP_979733.1 4009381 D 410289 CDS YP_979734.1 121639510 4695712 complement(4010292..4012046) 1 NC_008769.1 PE-PGRS family protein 4012046 PE_PGRS58 4695712 PE_PGRS58 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_979734.1 4010292 R 410289 CDS YP_979735.1 121639511 4697032 complement(4012157..4012930) 1 NC_008769.1 hydrolase 4012930 4697032 BCG_3656c Mycobacterium bovis BCG str. Pasteur 1173P2 hydrolase YP_979735.1 4012157 R 410289 CDS YP_979736.1 121639512 4698261 4012945..4013262 1 NC_008769.1 hypothetical protein 4013262 TB11.2 4698261 TB11.2 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979736.1 4012945 D 410289 CDS YP_979737.1 121639513 4697793 4013240..4014598 1 NC_008769.1 Differs from Rv3593 by 2 aa, V159A, S186N; lipoprotein lpqF 4014598 lpqF 4697793 lpqF Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqF YP_979737.1 4013240 D 410289 CDS YP_979738.1 121639514 4696109 4014745..4015572 1 NC_008769.1 hypothetical protein 4015572 4696109 BCG_3659 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979738.1 4014745 D 410289 CDS YP_979739.1 121639515 4698949 complement(4015486..4016964) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (a-*) and a 27 bp insertion (*-gcgcgccggggccaccgtttccgccgg), lead to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (492 aa versus 439 aa); PE-PGRS family protein 4016964 PE_PGRS59 4698949 PE_PGRS59 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_979739.1 4015486 R 410289 CDS YP_979740.1 121639516 4699251 complement(4017072..4019618) 1 NC_008769.1 ATP-dependent Clp protease ATP-binding subunit clpC 4019618 clpC 4699251 clpC Mycobacterium bovis BCG str. Pasteur 1173P2 ATP-dependent Clp protease ATP-binding subunit clpC YP_979740.1 4017072 R 410289 CDS YP_979741.1 121639517 4698474 complement(4019895..4020233) 1 NC_008769.1 lsr2 protein precursor 4020233 lsr2 4698474 lsr2 Mycobacterium bovis BCG str. Pasteur 1173P2 lsr2 protein precursor YP_979741.1 4019895 R 410289 CDS YP_979742.1 121639518 4697260 complement(4020337..4021854) 1 NC_008769.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 4021854 lysS 4697260 lysS Mycobacterium bovis BCG str. Pasteur 1173P2 lysyl-tRNA synthetase YP_979742.1 4020337 R 410289 CDS YP_979743.1 121639519 4697178 complement(4021955..4022773) 1 NC_008769.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 4022773 4697178 BCG_3664c Mycobacterium bovis BCG str. Pasteur 1173P2 pantothenate kinase YP_979743.1 4021955 R 410289 CDS YP_979744.1 121639520 4699169 complement(4022776..4023195) 1 NC_008769.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 4023195 panD 4699169 panD Mycobacterium bovis BCG str. Pasteur 1173P2 aspartate alpha-decarboxylase YP_979744.1 4022776 R 410289 CDS YP_979745.1 121639521 4698053 complement(4023195..4024124) 1 NC_008769.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 4024124 panC 4698053 panC Mycobacterium bovis BCG str. Pasteur 1173P2 pantoate--beta-alanine ligase YP_979745.1 4023195 R 410289 CDS YP_979746.1 121639522 4695408 complement(4024121..4025032) 1 NC_008769.1 hypothetical protein 4025032 4695408 BCG_3667c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979746.1 4024121 R 410289 CDS YP_979747.1 121639523 4698768 complement(4025217..4026410) 1 NC_008769.1 Differs from Rv3604c by G153V; transmembrane protein rich in alanine and arginine and proline 4026410 4698768 BCG_3668c Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane protein rich in alanine and arginine and proline YP_979747.1 4025217 R 410289 CDS YP_979748.1 121639524 4699077 complement(4026619..4027095) 1 NC_008769.1 hypothetical protein 4027095 4699077 BCG_3669c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979748.1 4026619 R 410289 CDS YP_979749.1 121639525 4698844 complement(4027095..4027661) 1 NC_008769.1 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 4027661 folK 4698844 folK Mycobacterium bovis BCG str. Pasteur 1173P2 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_979749.1 4027095 R 410289 CDS YP_979750.1 121639526 4695627 complement(4027658..4028059) 1 NC_008769.1 dihydroneopterin aldolase folB 4028059 folB 4695627 folB Mycobacterium bovis BCG str. Pasteur 1173P2 dihydroneopterin aldolase folB YP_979750.1 4027658 R 410289 CDS YP_979751.1 121639527 4697986 complement(4028052..4028894) 1 NC_008769.1 dihydropteroate synthase 4028894 folP1 4697986 folP1 Mycobacterium bovis BCG str. Pasteur 1173P2 dihydropteroate synthase YP_979751.1 4028052 R 410289 CDS YP_979752.1 121639528 4695628 complement(4028891..4029499) 1 NC_008769.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 4029499 folE 4695628 folE Mycobacterium bovis BCG str. Pasteur 1173P2 GTP cyclohydrolase I YP_979752.1 4028891 R 410289 CDS YP_979753.1 121639529 4695626 complement(4029515..4031797) 1 NC_008769.1 membrane-bound protease ftsH 4031797 ftsH 4695626 ftsH Mycobacterium bovis BCG str. Pasteur 1173P2 membrane-bound protease ftsH YP_979753.1 4029515 R 410289 CDS YP_979754.1 121639530 4695822 4031864..4032517 1 NC_008769.1 Identical to Rv3611. In Mycobacterium bovis, a 111 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis (180 aa versus 217 aa); hypothetical protein 4032517 4695822 BCG_3675 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979754.1 4031864 D 410289 CDS YP_979755.1 121639531 4698520 complement(4032432..4032761) 1 NC_008769.1 hypothetical protein 4032761 4698520 BCG_3676c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979755.1 4032432 R 410289 CDS YP_979756.1 121639532 4698584 complement(4032795..4032956) 1 NC_008769.1 hypothetical protein 4032956 4698584 BCG_3677c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979756.1 4032795 R 410289 CDS YP_979757.1 121639533 4698944 complement(4033056..4033610) 1 NC_008769.1 hypothetical protein 4033610 4698944 BCG_3678c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979757.1 4033056 R 410289 CDS YP_979758.1 121639534 4699279 complement(4033726..4034037) 1 NC_008769.1 hypothetical protein 4034037 4699279 BCG_3679c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979758.1 4033726 R 410289 CDS YP_979759.1 121639535 4699212 complement(4034111..4035289) 1 NC_008769.1 Differs from Rv3616c by 2aa, V4A, I192T and Mb3646c by 2aa, V4A, V153A; hypothetical protein 4035289 4699212 BCG_3680c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979759.1 4034111 R 410289 CDS YP_979760.1 121639536 4698264 4035755..4036270 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a large 5894 bp deletion (RD8) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (171 aa versus 240 aa); lipoprotein lpqG 4036270 lpqG 4698264 lpqG Mycobacterium bovis BCG str. Pasteur 1173P2 lipoprotein lpqG YP_979760.1 4035755 D 410289 CDS YP_979761.1 121639537 4698154 complement(4036275..4036925) 1 NC_008769.1 Differs by 2 aa from Rv3624c et Mb3648c A111T, N122D; hypoxanthine-guanine phosphoribosyltransferase hpt 4036925 hpt 4698154 hpt Mycobacterium bovis BCG str. Pasteur 1173P2 hypoxanthine-guanine phosphoribosyltransferase hpt YP_979761.1 4036275 R 410289 CDS YP_979762.1 121639538 4696102 complement(4036922..4037893) 1 NC_008769.1 cell cycle protein mesJ 4037893 mesJ 4696102 mesJ Mycobacterium bovis BCG str. Pasteur 1173P2 cell cycle protein mesJ YP_979762.1 4036922 R 410289 CDS YP_979763.1 121639539 4696115 complement(4037872..4038924) 1 NC_008769.1 hypothetical protein 4038924 4696115 BCG_3684c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979763.1 4037872 R 410289 CDS YP_979764.1 121639540 4698621 complement(4038921..4040306) 1 NC_008769.1 Differs from Rv3627c by 2 aa, V45A, V81A; hypothetical protein 4040306 4698621 BCG_3685c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979764.1 4038921 R 410289 CDS YP_979765.1 121639541 4699299 4040444..4040932 1 NC_008769.1 inorganic pyrophosphatase ppa 4040932 ppa 4699299 ppa Mycobacterium bovis BCG str. Pasteur 1173P2 inorganic pyrophosphatase ppa YP_979765.1 4040444 D 410289 CDS YP_979766.1 121639542 4696281 complement(4040978..4042075) 1 NC_008769.1 hypothetical protein 4042075 4696281 BCG_3687c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979766.1 4040978 R 410289 CDS YP_979767.1 121639543 4699088 4042196..4043491 1 NC_008769.1 Differs from Rv3630 by 1aa, T40A; integral membrane protein 4043491 4699088 BCG_3688 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_979767.1 4042196 D 410289 CDS YP_979768.1 121639544 4698518 4043535..4044260 1 NC_008769.1 transferase 4044260 4698518 BCG_3689 Mycobacterium bovis BCG str. Pasteur 1173P2 transferase YP_979768.1 4043535 D 410289 CDS YP_979769.1 121639545 4699296 4044257..4044601 1 NC_008769.1 hypothetical protein 4044601 4699296 BCG_3690 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979769.1 4044257 D 410289 CDS YP_979770.1 121639546 4698226 4044812..4045687 1 NC_008769.1 hypothetical protein 4045687 4698226 BCG_3691 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979770.1 4044812 D 410289 CDS YP_979771.1 121639547 4698843 complement(4045688..4046632) 1 NC_008769.1 UDP-glucose 4-epimerase 4046632 galE1 4698843 galE1 Mycobacterium bovis BCG str. Pasteur 1173P2 UDP-glucose 4-epimerase YP_979771.1 4045688 R 410289 CDS YP_979772.1 121639548 4695530 4046655..4048430 1 NC_008769.1 hypothetical protein 4048430 4695530 BCG_3693 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979772.1 4046655 D 410289 CDS YP_979773.1 121639549 4698385 4048773..4049120 1 NC_008769.1 transposase 4049120 4698385 BCG_3694 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979773.1 4048773 D 410289 CDS YP_979774.1 121639550 4698738 4049505..4050005 1 NC_008769.1 transposase 4050005 4698738 BCG_3695 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979774.1 4049505 D 410289 CDS YP_979775.1 121639551 4698551 4050005..4050751 1 NC_008769.1 transposase 4050751 4698551 BCG_3696 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979775.1 4050005 D 410289 CDS YP_979776.1 121639552 4698928 complement(4050905..4051471) 1 NC_008769.1 Differs from Rv3639c by 1 aa, N53K; hypothetical protein 4051471 4698928 BCG_3697c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979776.1 4050905 R 410289 CDS YP_979777.1 121639553 4699238 complement(4051541..4052770) 1 NC_008769.1 Differs from Rv3640c by 1aa, E296G; transposase 4052770 4699238 BCG_3698c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979777.1 4051541 R 410289 CDS YP_979778.1 121639554 4698793 complement(4052946..4053581) 1 NC_008769.1 cell filamentation protein fic 4053581 fic 4698793 fic Mycobacterium bovis BCG str. Pasteur 1173P2 cell filamentation protein fic YP_979778.1 4052946 R 410289 CDS YP_979779.1 121639555 4695795 complement(4053592..4053786) 1 NC_008769.1 hypothetical protein 4053786 4695795 BCG_3700c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979779.1 4053592 R 410289 CDS YP_979780.1 121639556 4698384 4054181..4054372 1 NC_008769.1 hypothetical protein 4054372 4698384 BCG_3701 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979780.1 4054181 D 410289 CDS YP_979781.1 121639557 4698406 complement(4054537..4055742) 1 NC_008769.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 4055742 4698406 BCG_3702c Mycobacterium bovis BCG str. Pasteur 1173P2 DNA polymerase III subunit delta' YP_979781.1 4054537 R 410289 CDS YP_979782.1 121639558 4699236 4055828..4057477 1 NC_008769.1 hypothetical protein 4057477 4699236 BCG_3703 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979782.1 4055828 D 410289 CDS YP_979783.1 121639559 4698825 complement(4057474..4060278) 1 NC_008769.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 4060278 topA 4698825 topA Mycobacterium bovis BCG str. Pasteur 1173P2 DNA topoisomerase I YP_979783.1 4057474 R 410289 CDS YP_979784.1 121639560 4696388 complement(4060631..4061209) 1 NC_008769.1 hypothetical protein 4061209 4696388 BCG_3705c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979784.1 4060631 R 410289 CDS YP_979785.1 121639561 4698444 complement(4061349..4061552) 1 NC_008769.1 cold shock protein A cspA 4061552 cspA 4698444 cspA Mycobacterium bovis BCG str. Pasteur 1173P2 cold shock protein A cspA YP_979785.1 4061349 R 410289 CDS YP_979786.1 121639562 4697990 4061802..4064117 1 NC_008769.1 Differs from Rv3649 by 2aa, P93L, D677G, and from Mb3673 by D677G; helicase 4064117 4697990 BCG_3707 Mycobacterium bovis BCG str. Pasteur 1173P2 helicase YP_979786.1 4061802 D 410289 CDS YP_979787.1 121639563 4699044 4064254..4064538 1 NC_008769.1 PE family protein 4064538 PE33 4699044 PE33 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_979787.1 4064254 D 410289 CDS YP_979788.1 121639564 4698939 4064862..4065899 1 NC_008769.1 hypothetical protein 4065899 4698939 BCG_3709 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979788.1 4064862 D 410289 CDS YP_979789.1 121639565 4698896 4066653..4066967 1 NC_008769.1 PE-PGRS family protein 4066967 PE_PGRS60 4698896 PE_PGRS60 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_979789.1 4066653 D 410289 CDS YP_979790.1 121639566 4699252 4066961..4067656 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, a frameshift due to an in-frame insertion of 126 bp leads to a longer product than in Mycobacterium bovis, and in Mycobacterium bovis BCG Pasteur. Shorter than Mb3677 due to 18 bp in-frame deletion, removes 6 codons; PE-PGRS family protein 4067656 PE_PGRS61 4699252 PE_PGRS61 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_979790.1 4066961 D 410289 CDS YP_979791.1 121639567 4699253 complement(4067773..4068027) 1 NC_008769.1 hypothetical protein 4068027 4699253 BCG_3712c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979791.1 4067773 R 410289 CDS YP_979792.1 121639568 4698076 complement(4068113..4068412) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (c-*) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (99 aa versus 125 aa); hypothetical protein 4068412 4698076 BCG_3713c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979792.1 4068113 R 410289 CDS YP_979793.1 121639569 4698805 complement(4068436..4068642) 1 NC_008769.1 hypothetical protein 4068642 4698805 BCG_3714c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979793.1 4068436 R 410289 CDS YP_979794.1 121639570 4699194 complement(4068652..4069227) 1 NC_008769.1 alanine rich membrane protein 4069227 4699194 BCG_3715c Mycobacterium bovis BCG str. Pasteur 1173P2 alanine rich membrane protein YP_979794.1 4068652 R 410289 CDS YP_979795.1 121639571 4699173 complement(4069251..4070051) 1 NC_008769.1 hypothetical protein 4070051 4699173 BCG_3716c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979795.1 4069251 R 410289 CDS YP_979796.1 121639572 4698318 complement(4070048..4071106) 1 NC_008769.1 hypothetical protein 4071106 4698318 BCG_3717c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979796.1 4070048 R 410289 CDS YP_979797.1 121639573 4699192 complement(4071208..4072260) 1 NC_008769.1 Differs from Rv3660c by 1aa, L30P; hypothetical protein 4072260 4699192 BCG_3718c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979797.1 4071208 R 410289 CDS YP_979798.1 121639574 4698484 4072760..4073623 1 NC_008769.1 Differs from Rv3661 by 1aa, P40S; hypothetical protein 4073623 4698484 BCG_3719 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979798.1 4072760 D 410289 CDS YP_979799.1 121639575 4698916 complement(4074378..4075148) 1 NC_008769.1 Differs from Rv3662c by 1aa, T34A; hypothetical protein 4075148 4698916 BCG_3720c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979799.1 4074378 R 410289 CDS YP_979800.1 121639576 4698898 complement(4075145..4076791) 1 NC_008769.1 dipeptide-transport ATP-binding protein ABC transporter dppD 4076791 dppD 4698898 dppD Mycobacterium bovis BCG str. Pasteur 1173P2 dipeptide-transport ATP-binding protein ABC transporter dppD YP_979800.1 4075145 R 410289 CDS YP_979801.1 121639577 4698802 complement(4076788..4077588) 1 NC_008769.1 dipeptide-transport integral membrane protein ABC transporter dppC 4077588 dppC 4698802 dppC Mycobacterium bovis BCG str. Pasteur 1173P2 dipeptide-transport integral membrane protein ABC transporter dppC YP_979801.1 4076788 R 410289 CDS YP_979802.1 121639578 4696481 complement(4077644..4078570) 1 NC_008769.1 dipeptide-transport integral membrane protein ABC transporter dppB 4078570 dppB 4696481 dppB Mycobacterium bovis BCG str. Pasteur 1173P2 dipeptide-transport integral membrane protein ABC transporter dppB YP_979802.1 4077644 R 410289 CDS YP_979803.1 121639579 4697939 complement(4078572..4080197) 1 NC_008769.1 Differs from Rv3666c by 2aa, R4Q, Q443R and to Mb3690c by 1aa, E451G; periplasmic dipeptide-binding lipoprotein dppA 4080197 dppA 4697939 dppA Mycobacterium bovis BCG str. Pasteur 1173P2 periplasmic dipeptide-binding lipoprotein dppA YP_979803.1 4078572 R 410289 CDS YP_979804.1 121639580 4698601 4080905..4082860 1 NC_008769.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 4082860 acs 4698601 acs Mycobacterium bovis BCG str. Pasteur 1173P2 acetyl-CoA synthetase YP_979804.1 4080905 D 410289 CDS YP_979805.1 121639581 4695637 complement(4082896..4083594) 1 NC_008769.1 protease 4083594 4695637 BCG_3726c Mycobacterium bovis BCG str. Pasteur 1173P2 protease YP_979805.1 4082896 R 410289 CDS YP_979806.1 121639582 4698522 4083940..4084458 1 NC_008769.1 hypothetical protein 4084458 4698522 BCG_3727 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979806.1 4083940 D 410289 CDS YP_979807.1 121639583 4698769 4084459..4085442 1 NC_008769.1 epoxide hydrolase ephE 4085442 ephE 4698769 ephE Mycobacterium bovis BCG str. Pasteur 1173P2 epoxide hydrolase ephE YP_979807.1 4084459 D 410289 CDS YP_979808.1 121639584 4695460 complement(4085435..4086628) 1 NC_008769.1 Differs from Rv3671c by 3aa, T165N, L359F, V363I and from Mb3695c by 3aa, T165N and L359F; membrane-associated serine protease 4086628 4695460 BCG_3729c Mycobacterium bovis BCG str. Pasteur 1173P2 membrane-associated serine protease YP_979808.1 4085435 R 410289 CDS YP_979809.1 121639585 4697404 complement(4086634..4087455) 1 NC_008769.1 hypothetical protein 4087455 4697404 BCG_3730c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979809.1 4086634 R 410289 CDS YP_979810.1 121639586 4698365 complement(4087587..4088270) 1 NC_008769.1 membrane-anchored thioredoxin-like protein 4088270 4698365 BCG_3731c Mycobacterium bovis BCG str. Pasteur 1173P2 membrane-anchored thioredoxin-like protein YP_979810.1 4087587 R 410289 CDS YP_979811.1 121639587 4698863 complement(4088270..4089007) 1 NC_008769.1 endonuclease III nth 4089007 nth 4698863 nth Mycobacterium bovis BCG str. Pasteur 1173P2 endonuclease III nth YP_979811.1 4088270 R 410289 CDS YP_979812.1 121639588 4699184 4089115..4089492 1 NC_008769.1 hypothetical protein 4089492 4699184 BCG_3733 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979812.1 4089115 D 410289 CDS YP_979813.1 121639589 4698730 4089591..4090265 1 NC_008769.1 Differs from Rv3676 and Mb 3700 by 2aa, P47L, K178E; CRP/FNR family transcriptional regulator 4090265 4698730 BCG_3734 Mycobacterium bovis BCG str. Pasteur 1173P2 CRP/FNR family transcriptional regulator YP_979813.1 4089591 D 410289 CDS YP_979814.1 121639590 4699042 complement(4090371..4091165) 1 NC_008769.1 hydrolase 4091165 4699042 BCG_3735c Mycobacterium bovis BCG str. Pasteur 1173P2 hydrolase YP_979814.1 4090371 R 410289 CDS YP_979815.1 121639591 4699280 complement(4091172..4091627) 1 NC_008769.1 hypothetical protein 4091627 4699280 BCG_3736c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979815.1 4091172 R 410289 CDS YP_979816.1 121639592 4699315 complement(4091643..4091804) 1 NC_008769.1 hypothetical protein 4091804 4699315 BCG_3737c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979816.1 4091643 R 410289 CDS YP_979817.1 121639593 4699311 4091889..4092911 1 NC_008769.1 anion transporter atpase 4092911 4699311 BCG_3738 Mycobacterium bovis BCG str. Pasteur 1173P2 anion transporter atpase YP_979817.1 4091889 D 410289 CDS YP_979818.1 121639594 4699291 4092908..4094068 1 NC_008769.1 anion transporter atpase 4094068 4699291 BCG_3739 Mycobacterium bovis BCG str. Pasteur 1173P2 anion transporter atpase YP_979818.1 4092908 D 410289 CDS YP_979819.1 121639595 4699288 complement(4094311..4094667) 1 NC_008769.1 transcriptional regulatory protein whiB-like whiB4 4094667 whiB4 4699288 whiB4 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein whiB-like whiB4 YP_979819.1 4094311 R 410289 CDS YP_979820.1 121639596 4697343 4095029..4097461 1 NC_008769.1 bifunctional membrane-associated penicillin-binding protein 1A/1B ponA2 4097461 ponA2 4697343 ponA2 Mycobacterium bovis BCG str. Pasteur 1173P2 bifunctional membrane-associated penicillin-binding protein 1A/1B ponA2 YP_979820.1 4095029 D 410289 CDS YP_979821.1 121639597 4696280 4097530..4098489 1 NC_008769.1 hypothetical protein 4098489 4696280 BCG_3742 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979821.1 4097530 D 410289 CDS YP_979822.1 121639598 4699318 4098552..4099592 1 NC_008769.1 lyase 4099592 4699318 BCG_3743 Mycobacterium bovis BCG str. Pasteur 1173P2 lyase YP_979822.1 4098552 D 410289 CDS YP_979823.1 121639599 4695950 complement(4100408..4101838) 1 NC_008769.1 Differs from Rv3685c by 1aa, Q136E; cytochrome P450 137 cyp137 4101838 cyp137 4695950 cyp137 Mycobacterium bovis BCG str. Pasteur 1173P2 cytochrome P450 137 cyp137 YP_979823.1 4100408 R 410289 CDS YP_979824.1 121639600 4697464 complement(4101864..4102196) 1 NC_008769.1 hypothetical protein 4102196 4697464 BCG_3745c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979824.1 4101864 R 410289 CDS YP_979825.1 121639601 4698668 complement(4102436..4102681) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, truncation at the 5' start due to a single base transversion (g-t) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (81 aa versus 122 aa); hypothetical protein 4102681 4698668 BCG_3746c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979825.1 4102436 R 410289 CDS YP_979826.1 121639602 4698117 complement(4103006..4103470) 1 NC_008769.1 hypothetical protein 4103470 4698117 BCG_3747c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979826.1 4103006 R 410289 CDS YP_979827.1 121639603 4698401 4103470..4104825 1 NC_008769.1 Differs from Rv3689 by 1aa, L119V; hypothetical protein 4104825 4698401 BCG_3748 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979827.1 4103470 D 410289 CDS YP_979828.1 121639604 4698431 4104852..4105505 1 NC_008769.1 hypothetical protein 4105505 4698431 BCG_3749 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979828.1 4104852 D 410289 CDS YP_979829.1 121639605 4698416 4105631..4106632 1 NC_008769.1 hypothetical protein 4106632 4698416 BCG_3750 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979829.1 4105631 D 410289 CDS YP_979830.1 121639606 4698409 4106629..4107705 1 NC_008769.1 methanol dehydrogenase transcriptional regulatory protein moxR2 4107705 moxR2 4698409 moxR2 Mycobacterium bovis BCG str. Pasteur 1173P2 methanol dehydrogenase transcriptional regulatory protein moxR2 YP_979830.1 4106629 D 410289 CDS YP_979831.1 121639607 4698909 4107839..4109161 1 NC_008769.1 hypothetical protein 4109161 4698909 BCG_3752 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979831.1 4107839 D 410289 CDS YP_979832.1 121639608 4698400 complement(4109235..4110227) 1 NC_008769.1 hypothetical protein 4110227 4698400 BCG_3753c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979832.1 4109235 R 410289 CDS YP_979833.1 121639609 4698397 4110319..4111251 1 NC_008769.1 hypothetical protein 4111251 4698397 BCG_3754 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979833.1 4110319 D 410289 CDS YP_979834.1 121639610 4698362 complement(4111315..4112871) 1 NC_008769.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 4112871 glpK 4698362 glpK Mycobacterium bovis BCG str. Pasteur 1173P2 glycerol kinase YP_979834.1 4111315 R 410289 CDS YP_979835.1 121639611 4697771 complement(4112921..4113358) 1 NC_008769.1 Differs from Rv3697c by 1aa, R34G; hypothetical protein 4113358 4697771 BCG_3756c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979835.1 4112921 R 410289 CDS YP_979836.1 121639612 4697978 complement(4113355..4113579) 1 NC_008769.1 antitoxin 4113579 4697978 BCG_3756A Mycobacterium bovis BCG str. Pasteur 1173P2 antitoxin YP_979836.1 4113355 R 410289 CDS YP_979837.1 121639613 4698391 4113609..4115138 1 NC_008769.1 Differs from Rv3698 by 3aa, I66M, R233P, A288V and from Mb3724 by 1aa, A288V; hypothetical protein 4115138 4698391 BCG_3757 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979837.1 4113609 D 410289 CDS YP_979838.1 121639614 4698410 4115160..4115861 1 NC_008769.1 hypothetical protein 4115861 4698410 BCG_3758 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979838.1 4115160 D 410289 CDS YP_979839.1 121639615 4698386 complement(4115864..4117036) 1 NC_008769.1 hypothetical protein 4117036 4698386 BCG_3759c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979839.1 4115864 R 410289 CDS YP_979840.1 121639616 4698042 complement(4117067..4118032) 1 NC_008769.1 hypothetical protein 4118032 4698042 BCG_3760c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979840.1 4117067 R 410289 CDS YP_979841.1 121639617 4698387 complement(4118029..4118730) 1 NC_008769.1 hypothetical protein 4118730 4698387 BCG_3761c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979841.1 4118029 R 410289 CDS YP_979842.1 121639618 4698390 complement(4118730..4120007) 1 NC_008769.1 hypothetical protein 4120007 4698390 BCG_3762c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979842.1 4118730 R 410289 CDS YP_979843.1 121639619 4698389 complement(4120004..4121302) 1 NC_008769.1 glutamate--cysteine ligase 4121302 gshA 4698389 gshA Mycobacterium bovis BCG str. Pasteur 1173P2 glutamate--cysteine ligase YP_979843.1 4120004 R 410289 CDS YP_979844.1 121639620 4697813 complement(4121434..4122078) 1 NC_008769.1 hypothetical protein 4122078 4697813 BCG_3764c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979844.1 4121434 R 410289 CDS YP_979845.1 121639621 4698089 complement(4122207..4122596) 1 NC_008769.1 hypothetical protein 4122596 4698089 BCG_3765c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979845.1 4122207 R 410289 CDS YP_979846.1 121639622 4698204 complement(4122707..4123027) 1 NC_008769.1 hypothetical protein 4123027 4698204 BCG_3766c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979846.1 4122707 R 410289 CDS YP_979847.1 121639623 4698369 complement(4123146..4124156) 1 NC_008769.1 hypothetical protein 4124156 4698369 BCG_3767c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979847.1 4123146 R 410289 CDS YP_979848.1 121639624 4698017 complement(4124296..4125333) 1 NC_008769.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 4125333 asd 4698017 asd Mycobacterium bovis BCG str. Pasteur 1173P2 aspartate-semialdehyde dehydrogenase YP_979848.1 4124296 R 410289 CDS YP_979849.1 121639625 4697830 complement(4125334..4126599) 1 NC_008769.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 4126599 ask 4697830 ask Mycobacterium bovis BCG str. Pasteur 1173P2 aspartate kinase YP_979849.1 4125334 R 410289 CDS YP_979850.1 121639626 4698566 4126856..4129360 1 NC_008769.1 Protein is 190 aa longer than Rv3710, and 57 aa longer than Mb3737 due to differences in copy number of 19 codon repeat at 3'-end; 2-isopropylmalate synthase 4129360 leuA 4698566 leuA Mycobacterium bovis BCG str. Pasteur 1173P2 2-isopropylmalate synthase YP_979850.1 4126856 D 410289 CDS YP_979851.1 121639627 4695958 complement(4129426..4130415) 1 NC_008769.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 4130415 dnaQ 4695958 dnaQ Mycobacterium bovis BCG str. Pasteur 1173P2 DNA polymerase III subunit epsilon YP_979851.1 4129426 R 410289 CDS YP_979852.1 121639628 4699060 4130549..4131790 1 NC_008769.1 Differs from Rv3712 by 2aa, S200G, T351K; ligase 4131790 4699060 BCG_3772 Mycobacterium bovis BCG str. Pasteur 1173P2 ligase YP_979852.1 4130549 D 410289 CDS YP_979853.1 121639629 4698018 4131795..4132490 1 NC_008769.1 cobyric acid synthase cobQ2 4132490 cobQ2 4698018 cobQ2 Mycobacterium bovis BCG str. Pasteur 1173P2 cobyric acid synthase cobQ2 YP_979853.1 4131795 D 410289 CDS YP_979854.1 121639630 4699359 complement(4132499..4133389) 1 NC_008769.1 hypothetical protein 4133389 4699359 BCG_3774c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979854.1 4132499 R 410289 CDS YP_979855.1 121639631 4698177 complement(4133457..4134068) 1 NC_008769.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 4134068 recR 4698177 recR Mycobacterium bovis BCG str. Pasteur 1173P2 recombination protein RecR YP_979855.1 4133457 R 410289 CDS YP_979856.1 121639632 4695840 complement(4134080..4134481) 1 NC_008769.1 hypothetical protein 4134481 4695840 BCG_3776c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979856.1 4134080 R 410289 CDS YP_979857.1 121639633 4698374 4134616..4135341 1 NC_008769.1 hypothetical protein 4135341 4698374 BCG_3777 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979857.1 4134616 D 410289 CDS YP_979858.1 121639634 4698375 complement(4135383..4135826) 1 NC_008769.1 hypothetical protein 4135826 4698375 BCG_3778c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979858.1 4135383 R 410289 CDS YP_979859.1 121639635 4698377 4135874..4137286 1 NC_008769.1 Differs from Rv3719 by 1aa, A12T; hypothetical protein 4137286 4698377 BCG_3779 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979859.1 4135874 D 410289 CDS YP_979860.1 121639636 4698372 4137304..4138566 1 NC_008769.1 fatty acid synthase 4138566 4698372 BCG_3780 Mycobacterium bovis BCG str. Pasteur 1173P2 fatty acid synthase YP_979860.1 4137304 D 410289 CDS YP_979861.1 121639637 4698367 complement(4138563..4140299) 1 NC_008769.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 4140299 dnaZX 4698367 dnaZX Mycobacterium bovis BCG str. Pasteur 1173P2 DNA polymerase III subunits gamma and tau YP_979861.1 4138563 R 410289 CDS YP_979862.1 121639638 4696771 complement(4140389..4141696) 1 NC_008769.1 Differs from Rv3722c and Mb3749c by 1aa, Y314H; hypothetical protein 4141696 4696771 BCG_3782c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979862.1 4140389 R 410289 CDS YP_979863.1 121639639 4698403 4142104..4142868 1 NC_008769.1 hypothetical protein 4142868 4698403 BCG_3783 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979863.1 4142104 D 410289 CDS YP_979864.1 121639640 4698370 4143035..4143736 1 NC_008769.1 In Mycobacterium tuberculosis, Rv3724A and Rv3724B exist as 2 genes with an overlap region between them. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a single base deletion (t-*) leads to a single product; cutinase precursor cut5 4143736 cut5 4698370 cut5 Mycobacterium bovis BCG str. Pasteur 1173P2 cutinase precursor cut5 YP_979864.1 4143035 D 410289 CDS YP_979865.1 121639641 4695572 4143781..4144782 1 NC_008769.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a single base insertion (*-a) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (333 aa versus 309 aa); oxidoreductase 4144782 4695572 BCG_3785 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979865.1 4143781 D 410289 CDS YP_979866.1 121639642 4698361 4144989..4146182 1 NC_008769.1 Differs from Rv3726 by 1aa, S251R; dehydrogenase 4146182 4698361 BCG_3786 Mycobacterium bovis BCG str. Pasteur 1173P2 dehydrogenase YP_979866.1 4144989 D 410289 CDS YP_979867.1 121639643 4698354 4146523..4148331 1 NC_008769.1 Differs from Rv3727 by 1aa, M86V; oxidoreductase 4148331 4698354 BCG_3787 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979867.1 4146523 D 410289 CDS YP_979868.1 121639644 4698359 4148441..4151638 1 NC_008769.1 Differs from Rv3728 by 1aa, R464G; hypothetical protein 4151638 4698359 BCG_3788 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979868.1 4148441 D 410289 CDS YP_979869.1 121639645 4698353 4151853..4154183 1 NC_008769.1 Differs from Rv3729 by 2aa, I170V, S269P; transferase 4154183 4698353 BCG_3789 Mycobacterium bovis BCG str. Pasteur 1173P2 transferase YP_979869.1 4151853 D 410289 CDS YP_979870.1 121639646 4698356 complement(4154248..4155288) 1 NC_008769.1 hypothetical protein 4155288 4698356 BCG_3790c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979870.1 4154248 R 410289 CDS YP_979871.1 121639647 4698355 4155326..4156402 1 NC_008769.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth; ATP-dependent DNA ligase 4156402 ligC 4698355 ligC Mycobacterium bovis BCG str. Pasteur 1173P2 ATP-dependent DNA ligase YP_979871.1 4155326 D 410289 CDS YP_979872.1 121639648 4698685 4156502..4157560 1 NC_008769.1 hypothetical protein 4157560 4698685 BCG_3792 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979872.1 4156502 D 410289 CDS YP_979873.1 121639649 4698346 complement(4157580..4158080) 1 NC_008769.1 hypothetical protein 4158080 4698346 BCG_3793c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979873.1 4157580 R 410289 CDS YP_979874.1 121639650 4698336 complement(4158094..4159458) 1 NC_008769.1 hypothetical protein 4159458 4698336 BCG_3794c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979874.1 4158094 R 410289 CDS YP_979875.1 121639651 4698352 4159657..4160145 1 NC_008769.1 hypothetical protein 4160145 4698352 BCG_3795 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979875.1 4159657 D 410289 CDS YP_979876.1 121639652 4698381 4160202..4161263 1 NC_008769.1 Differs from Rv3736 and Mb3763 by 1aa, K76E; AraC family transcriptional regulator 4161263 4698381 BCG_3796 Mycobacterium bovis BCG str. Pasteur 1173P2 AraC family transcriptional regulator YP_979876.1 4160202 D 410289 CDS YP_979877.1 121639653 4698351 4161267..4162856 1 NC_008769.1 Differs from Rv3737 by 1aa, G40D; hypothetical protein 4162856 4698351 BCG_3797 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979877.1 4161267 D 410289 CDS YP_979878.1 121639654 4697699 complement(4163235..4164581) 1 NC_008769.1 Differs from Rv3740c by 1aa, C422R; hypothetical protein 4164581 4697699 BCG_3799c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979878.1 4163235 R 410289 CDS YP_979879.1 121639655 4698343 complement(4164581..4165255) 1 NC_008769.1 oxidoreductase 4165255 4698343 BCG_3800c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979879.1 4164581 R 410289 CDS YP_979880.1 121639656 4698337 complement(4165252..4165647) 1 NC_008769.1 oxidoreductase 4165647 4698337 BCG_3801c Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979880.1 4165252 R 410289 CDS YP_979881.1 121639657 4698093 complement(4165793..4167775) 1 NC_008769.1 cation transporter P-type atpase ctpJ 4167775 ctpJ 4698093 ctpJ Mycobacterium bovis BCG str. Pasteur 1173P2 cation transporter P-type atpase ctpJ YP_979881.1 4165793 R 410289 CDS YP_979882.1 121639658 4696477 4167842..4168204 1 NC_008769.1 ArsR family transcriptional regulator 4168204 4696477 BCG_3803 Mycobacterium bovis BCG str. Pasteur 1173P2 ArsR family transcriptional regulator YP_979882.1 4167842 D 410289 CDS YP_979883.1 121639659 4698332 complement(4168288..4168500) 1 NC_008769.1 hypothetical protein 4168500 4698332 BCG_3804c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979883.1 4168288 R 410289 CDS YP_979884.1 121639660 4698331 complement(4168573..4168908) 1 NC_008769.1 PE family protein 4168908 PE34 4698331 PE34 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_979884.1 4168573 R 410289 CDS YP_979885.1 121639661 4698940 4169126..4169509 1 NC_008769.1 hypothetical protein 4169509 4698940 BCG_3806 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979885.1 4169126 D 410289 CDS YP_979886.1 121639662 4698330 4169639..4169998 1 NC_008769.1 Differs from Rv3748 by 1aa, D107G; hypothetical protein 4169998 4698330 BCG_3807 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979886.1 4169639 D 410289 CDS YP_979887.1 121639663 4698334 complement(4170031..4170540) 1 NC_008769.1 hypothetical protein 4170540 4698334 BCG_3808c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979887.1 4170031 R 410289 CDS YP_979888.1 121639664 4698137 complement(4170608..4171000) 1 NC_008769.1 excisionase 4171000 4698137 BCG_3809c Mycobacterium bovis BCG str. Pasteur 1173P2 excisionase YP_979888.1 4170608 R 410289 CDS YP_979889.1 121639665 4698324 4171276..4171491 1 NC_008769.1 integrase 4171491 4698324 BCG_3810 Mycobacterium bovis BCG str. Pasteur 1173P2 integrase YP_979889.1 4171276 D 410289 CDS YP_979890.1 121639666 4698404 complement(4171649..4172107) 1 NC_008769.1 cytidine/deoxycytidylate deaminase 4172107 4698404 BCG_3811c Mycobacterium bovis BCG str. Pasteur 1173P2 cytidine/deoxycytidylate deaminase YP_979890.1 4171649 R 410289 CDS YP_979891.1 121639667 4698321 complement(4172123..4172644) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transition (t-c) leads to a longer product with a different 5' start compared to its homolog in Mycobacterium tuberculosis strain H37Rv (173 aa versus 166 aa); hypothetical protein 4172644 4698321 BCG_3812c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979891.1 4172123 R 410289 CDS YP_979892.1 121639668 4698304 4172823..4173728 1 NC_008769.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 4173728 tyrA 4698304 tyrA Mycobacterium bovis BCG str. Pasteur 1173P2 prephenate dehydrogenase YP_979892.1 4172823 D 410289 CDS YP_979893.1 121639669 4696863 complement(4173691..4174290) 1 NC_008769.1 hypothetical protein 4174290 4696863 BCG_3814c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979893.1 4173691 R 410289 CDS YP_979894.1 121639670 4698305 complement(4174296..4175015) 1 NC_008769.1 osmoprotectant (glycine betaine/carnitine/choline/l-proline) transport integral membrane protein ABC transporter proZ 4175015 proZ 4698305 proZ Mycobacterium bovis BCG str. Pasteur 1173P2 osmoprotectant (glycine betaine/carnitine/choline/l-proline) transport integral membrane protein ABC transporter proZ YP_979894.1 4174296 R 410289 CDS YP_979895.1 121639671 4697275 complement(4175012..4175701) 1 NC_008769.1 osmoprotectant (glycine betaine/carnitine/choline/l-proline) transport integral membrane protein ABC transporter proW 4175701 proW 4697275 proW Mycobacterium bovis BCG str. Pasteur 1173P2 osmoprotectant (glycine betaine/carnitine/choline/l-proline) transport integral membrane protein ABC transporter proW YP_979895.1 4175012 R 410289 CDS YP_979896.1 121639672 4696517 complement(4175689..4176819) 1 NC_008769.1 osmoprotectant (glycine betaine/carnitine/choline/l-proline) transport ATP-binding protein ABC transporter proV 4176819 proV 4696517 proV Mycobacterium bovis BCG str. Pasteur 1173P2 osmoprotectant (glycine betaine/carnitine/choline/l-proline) transport ATP-binding protein ABC transporter proV YP_979896.1 4175689 R 410289 CDS YP_979897.1 121639673 4696516 complement(4176828..4177775) 1 NC_008769.1 Differs from Rv3759c by 2aa, P85L, V176A; osmoprotectant (glycine betaine/carnitine/choline/l-proline) binding lipoprotein proX 4177775 proX 4696516 proX Mycobacterium bovis BCG str. Pasteur 1173P2 osmoprotectant (glycine betaine/carnitine/choline/l-proline) binding lipoprotein proX YP_979897.1 4176828 R 410289 CDS YP_979898.1 121639674 4696518 4177940..4178242 1 NC_008769.1 hypothetical protein 4178242 4696518 BCG_3819 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979898.1 4177940 D 410289 CDS YP_979899.1 121639675 4698311 complement(4178264..4179319) 1 NC_008769.1 acyl-CoA dehydrogenase fadE36 4179319 fadE36 4698311 fadE36 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE36 YP_979899.1 4178264 R 410289 CDS YP_979900.1 121639676 4695635 complement(4179398..4181278) 1 NC_008769.1 Differs from Rv3762c by 1aa, H345Y and from Mb3788c by 1aa, V161G; hydrolase 4181278 4695635 BCG_3821c Mycobacterium bovis BCG str. Pasteur 1173P2 hydrolase YP_979900.1 4179398 R 410289 CDS YP_979901.1 121639677 4698020 4181449..4181928 1 NC_008769.1 19 kDa lipoprotein antigen precursor lpqH 4181928 lpqH 4698020 lpqH Mycobacterium bovis BCG str. Pasteur 1173P2 19 kDa lipoprotein antigen precursor lpqH YP_979901.1 4181449 D 410289 CDS YP_979902.1 121639678 4698155 complement(4181984..4183411) 1 NC_008769.1 Differs from Rv3764c by 2aa, R45H, R246C; two component sensor kinase 4183411 4698155 BCG_3823c Mycobacterium bovis BCG str. Pasteur 1173P2 two component sensor kinase YP_979902.1 4181984 R 410289 CDS YP_979903.1 121639679 4698301 complement(4183482..4184186) 1 NC_008769.1 two component transcriptional regulator 4184186 4698301 BCG_3824c Mycobacterium bovis BCG str. Pasteur 1173P2 two component transcriptional regulator YP_979903.1 4183482 R 410289 CDS YP_979904.1 121639680 4698292 4184695..4185384 1 NC_008769.1 hypothetical protein 4185384 4698292 BCG_3825 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979904.1 4184695 D 410289 CDS YP_979905.1 121639681 4698297 complement(4185398..4186342) 1 NC_008769.1 hypothetical protein 4186342 4698297 BCG_3826c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979905.1 4185398 R 410289 CDS YP_979906.1 121639682 4698300 4186472..4186831 1 NC_008769.1 hypothetical protein 4186831 4698300 BCG_3827 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979906.1 4186472 D 410289 CDS YP_979907.1 121639683 4698302 4187017..4187289 1 NC_008769.1 hypothetical protein 4187289 4698302 BCG_3828 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979907.1 4187017 D 410289 CDS YP_979908.1 121639684 4698298 complement(4187602..4188177) 1 NC_008769.1 Differs from Rv3770c by 1aa, A98P; hypothetical protein 4188177 4698298 BCG_3829c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979908.1 4187602 R 410289 CDS YP_979909.1 121639685 4698285 complement(4188283..4188465) 1 NC_008769.1 remnant of a transposase 4188465 4698285 BCG_3830c Mycobacterium bovis BCG str. Pasteur 1173P2 remnant of a transposase YP_979909.1 4188283 R 410289 CDS YP_979910.1 121639686 4698288 complement(4188480..4188671) 1 NC_008769.1 remnant of a transposase 4188671 4698288 BCG_3831c Mycobacterium bovis BCG str. Pasteur 1173P2 remnant of a transposase YP_979910.1 4188480 R 410289 CDS YP_979911.1 121639687 4698287 complement(4188806..4189132) 1 NC_008769.1 hypothetical protein 4189132 4698287 BCG_3832c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979911.1 4188806 R 410289 CDS YP_979912.1 121639688 4695951 4189536..4190597 1 NC_008769.1 Differs from Rv3772 by 1aa, A142T; aminotransferase 4190597 hisC2 4695951 hisC2 Mycobacterium bovis BCG str. Pasteur 1173P2 aminotransferase YP_979912.1 4189536 D 410289 CDS YP_979913.1 121639689 4696167 complement(4190643..4190987) 1 NC_008769.1 In Mycobacterium tuberculosis Rv3773c exists as a single gene. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-a) splits Rv3773c in two parts; hypothetical protein 4190987 4696167 BCG_3834c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979913.1 4190643 R 410289 CDS YP_979914.1 121639690 4698176 complement(4190992..4191228) 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv, Rv3773c exists as a single gene. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-a) splits Rv3773c into 2 parts; hypothetical protein 4191228 4698176 BCG_3835c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979914.1 4190992 R 410289 CDS YP_979915.1 121639691 4698295 4191252..4192076 1 NC_008769.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 4192076 echA21 4698295 echA21 Mycobacterium bovis BCG str. Pasteur 1173P2 enoyl-CoA hydratase YP_979915.1 4191252 D 410289 CDS YP_979916.1 121639692 4697251 4192088..4193335 1 NC_008769.1 lipase lipE 4193335 lipE 4697251 lipE Mycobacterium bovis BCG str. Pasteur 1173P2 lipase lipE YP_979916.1 4192088 D 410289 CDS YP_979917.1 121639693 4698084 4193492..4195051 1 NC_008769.1 Differs from Rv3776 by 1aa, V329M; hypothetical protein 4195051 4698084 BCG_3838 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979917.1 4193492 D 410289 CDS YP_979918.1 121639694 4698402 4195097..4196083 1 NC_008769.1 Differs from Rv3777 by 1aa, A160V; oxidoreductase 4196083 4698402 BCG_3839 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979918.1 4195097 D 410289 CDS YP_979919.1 121639695 4698282 complement(4196102..4197298) 1 NC_008769.1 aminotransferase 4197298 4698282 BCG_3840c Mycobacterium bovis BCG str. Pasteur 1173P2 aminotransferase YP_979919.1 4196102 R 410289 CDS YP_979920.1 121639696 4698291 4197388..4199388 1 NC_008769.1 transmembrane protein alanine and leucine rich 4199388 4698291 BCG_3841 Mycobacterium bovis BCG str. Pasteur 1173P2 transmembrane protein alanine and leucine rich YP_979920.1 4197388 D 410289 CDS YP_979921.1 121639697 4698673 4199392..4199928 1 NC_008769.1 hypothetical protein 4199928 4698673 BCG_3842 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979921.1 4199392 D 410289 CDS YP_979922.1 121639698 4698296 4199932..4200753 1 NC_008769.1 O-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter rfbE 4200753 rbfE 4698296 rbfE Mycobacterium bovis BCG str. Pasteur 1173P2 O-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter rfbE YP_979922.1 4199932 D 410289 CDS YP_979923.1 121639699 4697307 4200750..4201664 1 NC_008769.1 L-rhamnosyltransferase 4201664 4697307 BCG_3844 Mycobacterium bovis BCG str. Pasteur 1173P2 L-rhamnosyltransferase YP_979923.1 4200750 D 410289 CDS YP_979924.1 121639700 4698159 4201661..4202503 1 NC_008769.1 O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter rfbD 4202503 rfbD 4698159 rfbD Mycobacterium bovis BCG str. Pasteur 1173P2 O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter rfbD YP_979924.1 4201661 D 410289 CDS YP_979925.1 121639701 4696797 4202659..4203639 1 NC_008769.1 dTDP-glucose 4,6-dehydratase rfbB 4203639 rfbB 4696797 rfbB Mycobacterium bovis BCG str. Pasteur 1173P2 dTDP-glucose 4,6-dehydratase rfbB YP_979925.1 4202659 D 410289 CDS YP_979926.1 121639702 4696796 4203723..4204796 1 NC_008769.1 hypothetical protein 4204796 4696796 BCG_3847 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979926.1 4203723 D 410289 CDS YP_979927.1 121639703 4698270 complement(4204777..4206000) 1 NC_008769.1 hypothetical protein 4206000 4698270 BCG_3848c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979927.1 4204777 R 410289 CDS YP_979928.1 121639704 4698283 complement(4206013..4206939) 1 NC_008769.1 hypothetical protein 4206939 4698283 BCG_3849c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979928.1 4206013 R 410289 CDS YP_979929.1 121639705 4698286 4207183..4207668 1 NC_008769.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 4207668 4698286 BCG_3850 Mycobacterium bovis BCG str. Pasteur 1173P2 nucleoside diphosphate kinase regulator YP_979929.1 4207183 D 410289 CDS YP_979930.1 121639706 4698278 4207777..4208142 1 NC_008769.1 hypothetical protein 4208142 4698278 BCG_3851 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979930.1 4207777 D 410289 CDS YP_979931.1 121639707 4698083 4208182..4209567 1 NC_008769.1 oxidoreductase 4209567 4698083 BCG_3852 Mycobacterium bovis BCG str. Pasteur 1173P2 oxidoreductase YP_979931.1 4208182 D 410289 CDS YP_979932.1 121639708 4698118 4209568..4210332 1 NC_008769.1 short chain dehydrogenase 4210332 4698118 BCG_3853 Mycobacterium bovis BCG str. Pasteur 1173P2 short chain dehydrogenase YP_979932.1 4209568 D 410289 CDS YP_979933.1 121639709 4698115 4210335..4212266 1 NC_008769.1 hypothetical protein 4212266 4698115 BCG_3854 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979933.1 4210335 D 410289 CDS YP_979934.1 121639710 4698561 4212266..4215550 1 NC_008769.1 Differs from Rv3793 by 1aa, I270T; integral membrane indolylacetylinositol arabinosyltransferase embC 4215550 embC 4698561 embC Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane indolylacetylinositol arabinosyltransferase embC YP_979934.1 4212266 D 410289 CDS YP_979935.1 121639711 4697214 4215636..4218920 1 NC_008769.1 integral membrane indolylacetylinositol arabinosyltransferase embA 4218920 embA 4697214 embA Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane indolylacetylinositol arabinosyltransferase embA YP_979935.1 4215636 D 410289 CDS YP_979936.1 121639712 4697919 4218917..4222213 1 NC_008769.1 Differs from Rv3795 by 2aa, S13N, A378E; integral membrane indolylacetylinositol arabinosyltransferase embB 4222213 embB 4697919 embB Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane indolylacetylinositol arabinosyltransferase embB YP_979936.1 4218917 D 410289 CDS YP_979937.1 121639713 4695907 4222281..4223408 1 NC_008769.1 Differs from Rv3796 by 1aa, I320T; hypothetical protein 4223408 4695907 BCG_3858 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979937.1 4222281 D 410289 CDS YP_979938.1 121639714 4698276 4223488..4225269 1 NC_008769.1 acyl-CoA dehydrogenase fadE35 4225269 fadE35 4698276 fadE35 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA dehydrogenase fadE35 YP_979938.1 4223488 D 410289 CDS YP_979939.1 121639715 4695634 4225396..4226730 1 NC_008769.1 In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur, BCG_3860 and Rv3798 exist as a single gene. In Mycobacterium bovis, a frameshift due to a 11 bp deletion splits Rv3798 into 2 parts, Mb3827 and Mb3828; In Mycobacterium bovis, a frameshift due to a 11 bp deletion splits Rv3798 into 2 parts, Mb3827 and Mb3828; transposase 4226730 4695634 BCG_3860 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979939.1 4225396 D 410289 CDS YP_979940.1 121639716 4698603 complement(4226783..4228351) 1 NC_008769.1 propionyl-CoA carboxylase beta chain 4 accD4 4228351 accD4 4698603 accD4 Mycobacterium bovis BCG str. Pasteur 1173P2 propionyl-CoA carboxylase beta chain 4 accD4 YP_979940.1 4226783 R 410289 CDS YP_979941.1 121639717 4698784 complement(4228348..4233549) 1 NC_008769.1 Differs from Rv3800c by 2aa, G523A, N650S and from Mb3829c by 1aa, N650S; polyketide synthase 4233549 pks13 4698784 pks13 Mycobacterium bovis BCG str. Pasteur 1173P2 polyketide synthase YP_979941.1 4228348 R 410289 CDS YP_979942.1 121639718 4698457 complement(4233556..4235469) 1 NC_008769.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 4235469 fadD32 4698457 fadD32 Mycobacterium bovis BCG str. Pasteur 1173P2 long-chain-fatty-acid--CoA ligase YP_979942.1 4233556 R 410289 CDS YP_979943.1 121639719 4698948 complement(4235758..4236768) 1 NC_008769.1 hypothetical protein 4236768 4698948 BCG_3864c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979943.1 4235758 R 410289 CDS YP_979944.1 121639720 4698569 complement(4236966..4237865) 1 NC_008769.1 hypothetical protein 4237865 fbpD 4698569 fbpD Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979944.1 4236966 R 410289 CDS YP_979945.1 121639721 4696523 complement(4238045..4239061) 1 NC_008769.1 hypothetical protein 4239061 fbpA 4696523 fbpA Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979945.1 4238045 R 410289 CDS YP_979946.1 121639722 4696564 complement(4239356..4241239) 1 NC_008769.1 Differs from Rv3805c by 1aa, V327I; hypothetical protein 4241239 4696564 BCG_3867c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979946.1 4239356 R 410289 CDS YP_979947.1 121639723 4698675 complement(4241328..4242236) 1 NC_008769.1 catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate; phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase 4242236 4698675 BCG_3868c Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase YP_979947.1 4241328 R 410289 CDS YP_979948.1 121639724 4698606 complement(4242243..4242740) 1 NC_008769.1 hypothetical protein 4242740 4698606 BCG_3869c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979948.1 4242243 R 410289 CDS YP_979949.1 121639725 4699166 complement(4242769..4244682) 1 NC_008769.1 galactofuranosyl transferase 4244682 4699166 BCG_3870c Mycobacterium bovis BCG str. Pasteur 1173P2 galactofuranosyl transferase YP_979949.1 4242769 R 410289 CDS YP_979950.1 121639726 4696780 complement(4244679..4245878) 1 NC_008769.1 UDP-galactopyranose mutase 4245878 glf 4696780 glf Mycobacterium bovis BCG str. Pasteur 1173P2 UDP-galactopyranose mutase YP_979950.1 4244679 R 410289 CDS YP_979951.1 121639727 4697399 4246142..4246996 1 NC_008769.1 hypothetical protein 4246996 pirG 4697399 pirG Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979951.1 4246142 D 410289 CDS YP_979952.1 121639728 4699305 4247201..4248820 1 NC_008769.1 hypothetical protein 4248820 4699305 BCG_3873 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979952.1 4247201 D 410289 CDS YP_979953.1 121639729 4699336 4248974..4250488 1 NC_008769.1 PE-PGRS family protein 4250488 PE_PGRS62 4699336 PE_PGRS62 Mycobacterium bovis BCG str. Pasteur 1173P2 PE-PGRS family protein YP_979953.1 4248974 D 410289 CDS YP_979954.1 121639730 4699254 complement(4250797..4251618) 1 NC_008769.1 Differs from Rv3813c by 1aa, T83M; hypothetical protein 4251618 4699254 BCG_3875c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979954.1 4250797 R 410289 CDS YP_979955.1 121639731 4699269 complement(4251633..4252418) 1 NC_008769.1 acyltransferase 4252418 4699269 BCG_3876c Mycobacterium bovis BCG str. Pasteur 1173P2 acyltransferase YP_979955.1 4251633 R 410289 CDS YP_979956.1 121639732 4698695 complement(4252436..4253191) 1 NC_008769.1 acyltransferase 4253191 4698695 BCG_3877c Mycobacterium bovis BCG str. Pasteur 1173P2 acyltransferase YP_979956.1 4252436 R 410289 CDS YP_979957.1 121639733 4696537 complement(4253195..4253974) 1 NC_008769.1 acyltransferase 4253974 4696537 BCG_3878c Mycobacterium bovis BCG str. Pasteur 1173P2 acyltransferase YP_979957.1 4253195 R 410289 CDS YP_979958.1 121639734 4699024 4254050..4254805 1 NC_008769.1 phosphotransferase 4254805 4699024 BCG_3879 Mycobacterium bovis BCG str. Pasteur 1173P2 phosphotransferase YP_979958.1 4254050 D 410289 CDS YP_979959.1 121639735 4697921 4254852..4256402 1 NC_008769.1 hypothetical protein 4256402 4697921 BCG_3880 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979959.1 4254852 D 410289 CDS YP_979960.1 121639736 4698164 4256399..4256734 1 NC_008769.1 hypothetical protein 4256734 4698164 BCG_3881 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979960.1 4256399 D 410289 CDS YP_979961.1 121639737 4698002 complement(4256822..4258228) 1 NC_008769.1 Differs from Rv3820c by 1aa, I463T; polyketide synthase associated protein papA2 4258228 papA2 4698002 papA2 Mycobacterium bovis BCG str. Pasteur 1173P2 polyketide synthase associated protein papA2 YP_979961.1 4256822 R 410289 CDS YP_979962.1 121639738 4698055 4258376..4259089 1 NC_008769.1 Differs from Rv3821 by 2aa, N106D, T120A; integral membrane protein 4259089 4698055 BCG_3883 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane protein YP_979962.1 4258376 D 410289 CDS YP_979963.1 121639739 4698082 4259124..4259492 1 NC_008769.1 Corresponds to Rv3822/Mb3852 but is missing 1bp after codon 122. Differs from Rv3822 by 2aa, Y55C, T103N, in first part (and by 1aa , V92A, in the second part); hypothetical protein 4259492 4698082 BCG_3884 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979963.1 4259124 D 410289 CDS YP_979964.1 121639740 4698148 4259489..4260337 1 NC_008769.1 Corresponds to 3'-part of Rv3822/Mb3852 due to missing bp after codon 122. Differs from Rv3822 by 1aa, V92A (and by 2aa, Y55C, T105N, in first part; hypothetical protein 4260337 4698148 BCG_3885 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979964.1 4259489 D 410289 CDS YP_979965.1 121639741 4698033 complement(4260662..4263931) 1 NC_008769.1 Differs from Rv3823c by 2aa, R235G, A526V; integral membrane transport protein mmpL8 4263931 mmpL8 4698033 mmpL8 Mycobacterium bovis BCG str. Pasteur 1173P2 integral membrane transport protein mmpL8 YP_979965.1 4260662 R 410289 CDS YP_979966.1 121639742 4696174 complement(4264041..4265576) 1 NC_008769.1 polyketide synthase associated protein papA1 4265576 papA1 4696174 papA1 Mycobacterium bovis BCG str. Pasteur 1173P2 polyketide synthase associated protein papA1 YP_979966.1 4264041 R 410289 CDS YP_979967.1 121639743 4698054 complement(4265627..4272007) 1 NC_008769.1 Differs from Rv3825c and Mb3855c by 1aa, G829V; polyketide synthase 4272007 pks2 4698054 pks2 Mycobacterium bovis BCG str. Pasteur 1173P2 polyketide synthase YP_979967.1 4265627 R 410289 CDS YP_979968.1 121639744 4698460 4272214..4273968 1 NC_008769.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 4273968 fadD23 4698460 fadD23 Mycobacterium bovis BCG str. Pasteur 1173P2 acyl-CoA synthetase YP_979968.1 4272214 D 410289 CDS YP_979969.1 121639745 4695672 complement(4273965..4275191) 1 NC_008769.1 Differs from Rv3827c by 1aa, A251T; transposase 4275191 4695672 BCG_3890c Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979969.1 4273965 R 410289 CDS YP_979970.1 121639746 4698676 complement(4275188..4275799) 1 NC_008769.1 resolvase 4275799 4698676 BCG_3891c Mycobacterium bovis BCG str. Pasteur 1173P2 resolvase YP_979970.1 4275188 R 410289 CDS YP_979971.1 121639747 4698080 complement(4275800..4277410) 1 NC_008769.1 Differs from Rv3829c by 1aa, D54E; dehydrogenase 4277410 4698080 BCG_3892c Mycobacterium bovis BCG str. Pasteur 1173P2 dehydrogenase YP_979971.1 4275800 R 410289 CDS YP_979972.1 121639748 4698071 complement(4277458..4278087) 1 NC_008769.1 TetR family transcriptional regulator 4278087 4698071 BCG_3893c Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_979972.1 4277458 R 410289 CDS YP_979973.1 121639749 4698081 4278159..4278641 1 NC_008769.1 hypothetical protein 4278641 4698081 BCG_3894 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979973.1 4278159 D 410289 CDS YP_979974.1 121639750 4698045 complement(4278638..4279213) 1 NC_008769.1 hypothetical protein 4279213 4698045 BCG_3895c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979974.1 4278638 R 410289 CDS YP_979975.1 121639751 4698026 4279269..4280060 1 NC_008769.1 Differs from Rv3833 by 1aa, I105V; AraC family transcriptional regulator 4280060 4698026 BCG_3896 Mycobacterium bovis BCG str. Pasteur 1173P2 AraC family transcriptional regulator YP_979975.1 4279269 D 410289 CDS YP_979976.1 121639752 4698062 complement(4280057..4281316) 1 NC_008769.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 4281316 serS 4698062 serS Mycobacterium bovis BCG str. Pasteur 1173P2 seryl-tRNA synthetase YP_979976.1 4280057 R 410289 CDS YP_979977.1 121639753 4696252 4281449..4282807 1 NC_008769.1 Differs from Rv3835 and Mb3865 by 1 aa, Y79N, and frameshift due to extra C in C-string that changes C-terminus; hypothetical protein 4282807 4696252 BCG_3898 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979977.1 4281449 D 410289 CDS YP_979978.1 121639754 4698061 4282804..4283154 1 NC_008769.1 In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a single base insertion (*-g) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (116 aa versus 137 aa); hypothetical protein 4283154 4698061 BCG_3899 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979978.1 4282804 D 410289 CDS YP_979979.1 121639755 4698032 complement(4283413..4284111) 1 NC_008769.1 phosphoglycerate mutase 4284111 4698032 BCG_3900c Mycobacterium bovis BCG str. Pasteur 1173P2 phosphoglycerate mutase YP_979979.1 4283413 R 410289 CDS YP_979980.1 121639756 4698041 complement(4284108..4285073) 1 NC_008769.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 4285073 pheA 4698041 pheA Mycobacterium bovis BCG str. Pasteur 1173P2 prephenate dehydratase YP_979980.1 4284108 R 410289 CDS YP_979981.1 121639757 4698859 4285169..4285945 1 NC_008769.1 Differs from Rv3839 by 1aa, S122P; hypothetical protein 4285945 4698859 BCG_3902 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979981.1 4285169 D 410289 CDS YP_979982.1 121639758 4698019 4285971..4286384 1 NC_008769.1 transcriptional regulatory protein 4286384 4698019 BCG_3903 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein YP_979982.1 4285971 D 410289 CDS YP_979983.1 121639759 4698038 4286582..4287127 1 NC_008769.1 bacterioferritin bfrB 4287127 bfrB 4698038 bfrB Mycobacterium bovis BCG str. Pasteur 1173P2 bacterioferritin bfrB YP_979983.1 4286582 D 410289 CDS YP_979984.1 121639760 4696666 complement(4287142..4287966) 1 NC_008769.1 glycerophosphoryl diester phosphodiesterase glpQ1 4287966 glpQ1 4696666 glpQ1 Mycobacterium bovis BCG str. Pasteur 1173P2 glycerophosphoryl diester phosphodiesterase glpQ1 YP_979984.1 4287142 R 410289 CDS YP_979985.1 121639761 4697772 complement(4287972..4289000) 1 NC_008769.1 Differs from Rv3843c by 2aa, R11G, H92R; hypothetical protein 4289000 4697772 BCG_3906c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979985.1 4287972 R 410289 CDS YP_979986.1 121639762 4698007 4291178..4291669 1 NC_008769.1 transposase 4291669 4698007 BCG_3907 Mycobacterium bovis BCG str. Pasteur 1173P2 transposase YP_979986.1 4291178 D 410289 CDS YP_979987.1 121639763 4698012 4291684..4292043 1 NC_008769.1 hypothetical protein 4292043 4698012 BCG_3908 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979987.1 4291684 D 410289 CDS YP_979988.1 121639764 4697999 4293107..4293730 1 NC_008769.1 Differs from Rv3846 by 1aa, T205I; superoxide dismutase [Fe] sodA 4293730 sodA 4697999 sodA Mycobacterium bovis BCG str. Pasteur 1173P2 superoxide dismutase [Fe] sodA YP_979988.1 4293107 D 410289 CDS YP_979989.1 121639765 4697293 4293941..4294474 1 NC_008769.1 hypothetical protein 4294474 4697293 BCG_3910 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979989.1 4293941 D 410289 CDS YP_979990.1 121639766 4698004 4294729..4295637 1 NC_008769.1 Differs from Rv3848 by 1aa, I194V; hypothetical protein 4295637 4698004 BCG_3911 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979990.1 4294729 D 410289 CDS YP_979991.1 121639767 4697975 4295902..4296300 1 NC_008769.1 hypothetical protein 4296300 4697975 BCG_3912 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979991.1 4295902 D 410289 CDS YP_979992.1 121639768 4697906 4296418..4297074 1 NC_008769.1 hypothetical protein 4297074 4697906 BCG_3913 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979992.1 4296418 D 410289 CDS YP_979993.1 121639769 4695458 4297086..4297370 1 NC_008769.1 hypothetical protein 4297370 4695458 BCG_3914 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979993.1 4297086 D 410289 CDS YP_979994.1 121639770 4699355 4297477..4297881 1 NC_008769.1 histone-like protein hns 4297881 hns 4699355 hns Mycobacterium bovis BCG str. Pasteur 1173P2 histone-like protein hns YP_979994.1 4297477 D 410289 CDS YP_979995.1 121639771 4696101 4297898..4298371 1 NC_008769.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 4298371 menG 4696101 menG Mycobacterium bovis BCG str. Pasteur 1173P2 ribonuclease activity regulator protein RraA YP_979995.1 4297898 D 410289 CDS YP_979996.1 121639772 4696113 complement(4298407..4299876) 1 NC_008769.1 monooxygenase ethA 4299876 ethA 4696113 ethA Mycobacterium bovis BCG str. Pasteur 1173P2 monooxygenase ethA YP_979996.1 4298407 R 410289 CDS YP_979997.1 121639773 4696340 4299952..4300602 1 NC_008769.1 TetR family transcriptional regulator 4300602 ethR 4696340 ethR Mycobacterium bovis BCG str. Pasteur 1173P2 TetR family transcriptional regulator YP_979997.1 4299952 D 410289 CDS YP_979998.1 121639774 4696363 complement(4300804..4301811) 1 NC_008769.1 hypothetical protein 4301811 4696363 BCG_3919c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979998.1 4300804 R 410289 CDS YP_979999.1 121639775 4699337 complement(4301820..4302017) 1 NC_008769.1 hypothetical protein 4302017 4699337 BCG_3920c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_979999.1 4301820 R 410289 CDS YP_980000.1 121639776 4699323 complement(4302442..4303908) 1 NC_008769.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 4303908 gltD 4699323 gltD Mycobacterium bovis BCG str. Pasteur 1173P2 glutamate synthase subunit beta YP_980000.1 4302442 R 410289 CDS YP_980001.1 121639777 4696572 complement(4303901..4308484) 1 NC_008769.1 Differs from Rv3859c by 1aa, E553Q; ferredoxin-dependent glutamate synthase large subunit GltB 4308484 gltB 4696572 gltB Mycobacterium bovis BCG str. Pasteur 1173P2 ferredoxin-dependent glutamate synthase large subunit GltB YP_980001.1 4303901 R 410289 CDS YP_980002.1 121639778 4696571 4309180..4310241 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, a single base deletion leads to a shorter product compared to its homologs in Mycobacterium tuberculosis and Mycobacterium bovis; hypothetical protein 4310241 4696571 BCG_3923 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980002.1 4309180 D 410289 CDS YP_980003.1 121639779 4699320 4310348..4310674 1 NC_008769.1 hypothetical protein 4310674 4699320 BCG_3924 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980003.1 4310348 D 410289 CDS YP_980004.1 121639780 4699285 complement(4310573..4310923) 1 NC_008769.1 transcriptional regulatory protein whiB-like whiB6 4310923 whiB6 4699285 whiB6 Mycobacterium bovis BCG str. Pasteur 1173P2 transcriptional regulatory protein whiB-like whiB6 YP_980004.1 4310573 R 410289 CDS YP_980005.1 121639781 4697345 4311250..4312428 1 NC_008769.1 hypothetical protein 4312428 4697345 BCG_3926 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980005.1 4311250 D 410289 CDS YP_980006.1 121639782 4699278 4312671..4313927 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and in Mycobacterium bovis, two in-frame insertion of 36 and 12 bp, leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (418 aa versus 402 aa); hypothetical protein 4313927 4699278 BCG_3927 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980006.1 4312671 D 410289 CDS YP_980007.1 121639783 4699289 4314015..4314326 1 NC_008769.1 hypothetical protein 4314326 4699289 BCG_3928 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980007.1 4314015 D 410289 CDS YP_980008.1 121639784 4699310 4314329..4315180 1 NC_008769.1 hypothetical protein 4315180 4699310 BCG_3929 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980008.1 4314329 D 410289 CDS YP_980009.1 121639785 4699287 4315219..4315770 1 NC_008769.1 hypothetical protein 4315770 4699287 BCG_3930 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980009.1 4315219 D 410289 CDS YP_980010.1 121639786 4699301 4315763..4317484 1 NC_008769.1 Differs from Rv3868 by 1aa, V243A; hypothetical protein 4317484 4699301 BCG_3931 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980010.1 4315763 D 410289 CDS YP_980011.1 121639787 4699272 4317488..4318930 1 NC_008769.1 hypothetical protein 4318930 4699272 BCG_3932 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980011.1 4317488 D 410289 CDS YP_980012.1 121639788 4699250 4318930..4321173 1 NC_008769.1 hypothetical protein 4321173 4699250 BCG_3933 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980012.1 4318930 D 410289 CDS YP_980013.1 121639789 4699246 4321276..4322748 1 NC_008769.1 Differs from Rv3871 and Mb3901 by deletion of 101 codons after codon 480 due to BCG-specific RD1 deletion; hypothetical protein 4322748 4699246 BCG_3934 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980013.1 4321276 D 410289 CDS YP_980014.1 121639790 4699247 complement(4323191..4323538) 1 NC_008769.1 hypothetical protein 4323538 4699247 BCG_3935c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980014.1 4323191 R 410289 CDS YP_980015.1 121639791 4699243 complement(4323535..4324917) 1 NC_008769.1 Differs from Rv3881c by 7 codon stretch due to 1bp deletion and 1 bp insertion; hypothetical protein 4324917 4699243 BCG_3936c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980015.1 4323535 R 410289 CDS YP_980016.1 121639792 4699127 complement(4325024..4326412) 1 NC_008769.1 hypothetical protein 4326412 4699127 BCG_3937c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980016.1 4325024 R 410289 CDS YP_980017.1 121639793 4699188 complement(4326409..4327749) 1 NC_008769.1 Differs from Rv3883c by 1aa, A37T; protease 4327749 4699188 BCG_3938c Mycobacterium bovis BCG str. Pasteur 1173P2 protease YP_980017.1 4326409 R 410289 CDS YP_980018.1 121639794 4699102 complement(4327971..4329830) 1 NC_008769.1 Differs from Rv3884c by 1aa, G215E; hypothetical protein 4329830 4699102 BCG_3939c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980018.1 4327971 R 410289 CDS YP_980019.1 121639795 4699116 complement(4329900..4331513) 1 NC_008769.1 Differs from Rv3885c by 1aa, P133L; hypothetical protein 4331513 4699116 BCG_3940c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980019.1 4329900 R 410289 CDS YP_980020.1 121639796 4699074 complement(4331510..4333162) 1 NC_008769.1 hypothetical protein 4333162 4699074 BCG_3941c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980020.1 4331510 R 410289 CDS YP_980021.1 121639797 4699093 complement(4333147..4334676) 1 NC_008769.1 In Mycobacterium bovis, a deletion of 2406 bp (RDpan) leads to the loss of the NH2 part of Rv3887c, the entire Rv3888c and the COOH part of Rv3889c compared to Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur. Differs from Mb3917c by 1aa D346G; hypothetical protein 4334676 4699093 BCG_3942c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980021.1 4333147 R 410289 CDS YP_980022.1 121639798 4699071 complement(4334673..4335335) 1 NC_008769.1 Has no counterpart in Mycobacterium bovis owing to deletion of 2405bp between positions 4307384..4307385; hypothetical protein 4335335 4699071 BCG_3943c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980022.1 4334673 R 410289 CDS YP_980023.1 121639799 4699058 complement(4335332..4335697) 1 NC_008769.1 Has no counterpart in Mycobacterium bovis owing to deletion of 2405bp between positions 364165-364166; hypothetical protein 4335697 4699058 BCG_3944c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980023.1 4335332 R 410289 CDS YP_980024.1 121639800 4699056 complement(4335791..4336621) 1 NC_008769.1 In Mycobacterium bovis, a deletion of 2406 bases leads to the loss of the NH2 part of Rv3887c, the entire Rv3888c and the COOH part of Rv3889c compared to Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur; hypothetical protein 4336621 4699056 BCG_3945c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980024.1 4335791 R 410289 CDS YP_980025.1 121639801 4699365 complement(4336629..4337003) 1 NC_008769.1 In Mycobacterium bovis BCG Pasteur, and in Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (124 aa versus 95 aa); ESAT-6 like protein 11 esxC 4337003 esxC 4699365 esxC Mycobacterium bovis BCG str. Pasteur 1173P2 ESAT-6 like protein 11 esxC YP_980025.1 4336629 R 410289 CDS YP_980026.1 121639802 4696382 complement(4337039..4337362) 1 NC_008769.1 Differs from Rv3891c by 1aa, A49T; hypothetical protein 4337362 esxD 4696382 esxD Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980026.1 4337039 R 410289 CDS YP_980027.1 121639803 4695418 complement(4337473..4338672) 1 NC_008769.1 Differs from Rv3892c by 2aa, K19T, I206M and from Mb3921c by 1aa I206M; PPE family protein 4338672 PPE69 4695418 PPE69 Mycobacterium bovis BCG str. Pasteur 1173P2 PPE family protein YP_980027.1 4337473 R 410289 CDS YP_980028.1 121639804 4697700 complement(4338751..4338984) 1 NC_008769.1 PE family protein 4338984 PE36 4697700 PE36 Mycobacterium bovis BCG str. Pasteur 1173P2 PE family protein YP_980028.1 4338751 R 410289 CDS YP_980029.1 121639805 4698941 complement(4339251..4340936) 1 NC_008769.1 In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-c), splits Rv3894c into 2 parts; hypothetical protein 4340936 4698941 BCG_3950c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980029.1 4339251 R 410289 CDS YP_980030.1 121639806 4698517 complement(4340941..4343442) 1 NC_008769.1 In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-c), splits Rv3894c into 2 parts. Differs from first part of Rv3984c by 1aa, P258R; hypothetical protein 4343442 4698517 BCG_3951c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980030.1 4340941 R 410289 CDS YP_980031.1 121639807 4698237 complement(4343443..4344930) 1 NC_008769.1 Differs from Rv3895c by 1aa, G356D; hypothetical protein 4344930 4698237 BCG_3952c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980031.1 4343443 R 410289 CDS YP_980032.1 121639808 4699262 complement(4344974..4345840) 1 NC_008769.1 Differs from Rv3896c by 3aa, G83D, V186I, K193Q, and by frameshift due to 1bp deletion leading to shorter product (288aa versus 302aa); hypothetical protein 4345840 4699262 BCG_3953c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980032.1 4344974 R 410289 CDS YP_980033.1 121639809 4699284 complement(4345990..4346979) 1 NC_008769.1 In Mycobacterium tuberculosis, Rv3898c and Rv3897c exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base transition (t-c) leads to a single product; hypothetical protein 4346979 4699284 BCG_3954c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980033.1 4345990 R 410289 CDS YP_980034.1 121639810 4698234 complement(4347141..4348022) 1 NC_008769.1 In Mycobacterium tuberculosis, Rv3899c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur a frameshift due to a single base deletion (c-*) splits Rv3899c into 2 parts, Mb3928c and Mb3929c with the former being the more likely product; hypothetical protein 4348022 4698234 BCG_3955c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980034.1 4347141 R 410289 CDS YP_980035.1 121639811 4698132 complement(4348366..4349301) 1 NC_008769.1 Differs from Rv3900c by 1aa, A18P; hypothetical protein 4349301 4698132 BCG_3957c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980035.1 4348366 R 410289 CDS YP_980036.1 121639812 4698366 complement(4349410..4349805) 1 NC_008769.1 Differs from Rv3901c by 1aa, W21L, and frameshift due to 2bp deletion at 3'-end, and from Mb3931c by frameshift only; hypothetical protein 4349805 4698366 BCG_3958c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980036.1 4349410 R 410289 CDS YP_980037.1 121639813 4699193 complement(4350356..4350886) 1 NC_008769.1 hypothetical protein 4350886 4699193 BCG_3959c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980037.1 4350356 R 410289 CDS YP_980038.1 121639814 4698509 complement(4350883..4353423) 1 NC_008769.1 hypothetical protein 4353423 4698509 BCG_3960c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980038.1 4350883 R 410289 CDS YP_980039.1 121639815 4699350 complement(4353428..4353700) 1 NC_008769.1 Differs from Rv3904c by 1aa, V82M; ESAT-6 like protein 12 esxE 4353700 esxE 4699350 esxE Mycobacterium bovis BCG str. Pasteur 1173P2 ESAT-6 like protein 12 esxE YP_980039.1 4353428 R 410289 CDS YP_980040.1 121639816 4695412 complement(4353849..4354022) 1 NC_008769.1 In Mycobacterium bovis, and M.bovis BCG Pasteur, a single base transition (g-a) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (57 aa versus 103 aa); ESAT-6 like protein 13 esxF 4354022 esxF 4695412 esxF Mycobacterium bovis BCG str. Pasteur 1173P2 ESAT-6 like protein 13 esxF YP_980040.1 4353849 R 410289 CDS YP_980041.1 121639817 4697926 complement(4354088..4354597) 1 NC_008769.1 hypothetical protein 4354597 4697926 BCG_3963c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980041.1 4354088 R 410289 CDS YP_980042.1 121639818 4699371 complement(4354622..4356064) 1 NC_008769.1 poly(A) polymerase 4356064 pcnA 4699371 pcnA Mycobacterium bovis BCG str. Pasteur 1173P2 poly(A) polymerase YP_980042.1 4354622 R 410289 CDS YP_980043.1 121639819 4698419 4356440..4357186 1 NC_008769.1 hypothetical protein 4357186 4698419 BCG_3965 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980043.1 4356440 D 410289 CDS YP_980044.1 121639820 4698463 4357183..4359591 1 NC_008769.1 Differs from Rv3909 by 3aa, R7G, S399N, V538A and from Mb3939 by 1aa G25A; hypothetical protein 4359591 4698463 BCG_3966 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980044.1 4357183 D 410289 CDS YP_980045.1 121639821 4698553 4359588..4363142 1 NC_008769.1 Differs from Rv3910 by 1aa, A480V; hypothetical protein 4363142 4698553 BCG_3967 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980045.1 4359588 D 410289 CDS YP_980046.1 121639822 4698556 4363177..4363767 1 NC_008769.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase; RNA polymerase sigma factor SigM 4363767 sigMa_1 4698556 sigMa_1 Mycobacterium bovis BCG str. Pasteur 1173P2 RNA polymerase sigma factor SigM YP_980046.1 4363177 D 410289 CDS YP_980047.1 121639823 4696447 4363860..4364624 1 NC_008769.1 hypothetical protein 4364624 4696447 BCG_3970 Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980047.1 4363860 D 410289 CDS YP_980048.1 121639824 4698549 4364718..4365725 1 NC_008769.1 Differs from Rv3913 by 1aa, G57D; thioredoxin reductase trxB2 4365725 trxB2_1 4698549 trxB2_1 Mycobacterium bovis BCG str. Pasteur 1173P2 thioredoxin reductase trxB2 YP_980048.1 4364718 D 410289 CDS YP_980049.1 121639825 4696833 4365722..4366072 1 NC_008769.1 thioredoxin trxC 4366072 trxC_1 4696833 trxC_1 Mycobacterium bovis BCG str. Pasteur 1173P2 thioredoxin trxC YP_980049.1 4365722 D 410289 CDS YP_980050.1 121639826 4697087 4366182..4367402 1 NC_008769.1 hydrolase 4367402 4697087 BCG_3973 Mycobacterium bovis BCG str. Pasteur 1173P2 hydrolase YP_980050.1 4366182 D 410289 CDS YP_980051.1 121639827 4698559 complement(4367423..4368157) 1 NC_008769.1 hypothetical protein 4368157 4698559 BCG_3974c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980051.1 4367423 R 410289 CDS YP_980052.1 121639828 4698570 complement(4368447..4369481) 1 NC_008769.1 chromosome partitioning protein parB 4369481 parB_1 4698570 parB_1 Mycobacterium bovis BCG str. Pasteur 1173P2 chromosome partitioning protein parB YP_980052.1 4368447 R 410289 CDS YP_980053.1 121639829 4697550 complement(4369478..4370521) 1 NC_008769.1 chromosome partitioning protein parA 4370521 parA_1 4697550 parA_1 Mycobacterium bovis BCG str. Pasteur 1173P2 chromosome partitioning protein parA YP_980053.1 4369478 R 410289 CDS YP_980054.1 121639830 4697548 complement(4370518..4371192) 1 NC_008769.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 4371192 gidB 4697548 gidB Mycobacterium bovis BCG str. Pasteur 1173P2 16S rRNA methyltransferase GidB YP_980054.1 4370518 R 410289 CDS YP_980055.1 121639831 4698649 complement(4371324..4371887) 1 NC_008769.1 Differs from Rv3920c by 1aa, W110R; hypothetical protein 4371887 4698649 BCG_3978c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980055.1 4371324 R 410289 CDS YP_980056.1 121639832 4698562 complement(4371959..4373059) 1 NC_008769.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 4373059 4698562 BCG_3979c Mycobacterium bovis BCG str. Pasteur 1173P2 inner membrane protein translocase component YidC YP_980056.1 4371959 R 410289 CDS YP_980057.1 121639833 4698575 complement(4373043..4373405) 1 NC_008769.1 hypothetical protein 4373405 4698575 BCG_3980c Mycobacterium bovis BCG str. Pasteur 1173P2 hypothetical protein YP_980057.1 4373043 R 410289 CDS YP_980058.1 121639834 4698573 complement(4373402..4373779) 1 NC_008769.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 4373779 rnpA 4698573 rnpA Mycobacterium bovis BCG str. Pasteur 1173P2 ribonuclease P YP_980058.1 4373402 R 410289 CDS YP_980059.1 121639835 4697609 complement(4373776..4373919) 1 NC_008769.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 4373919 rpmH 4697609 rpmH Mycobacterium bovis BCG str. Pasteur 1173P2 50S ribosomal protein L34 YP_980059.1 4373776 R 410289 CDS