-- dump date   	20140619_151525
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_976107.1	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.
YP_976108.1	binds the polymerase to DNA and acts as a sliding clamp
YP_976109.1	Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_976110.1	Differs from Mb0004 by 1aa, S16L
YP_976111.1	negatively supercoils closed circular double-stranded DNA
YP_976112.1	negatively supercoils closed circular double-stranded DNA
YP_976113.1	Differs from Rv0007 by 1aa, I272V
YP_976114.1	Differs from Rv0008c by 1aa, P145S
YP_976116.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (g-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (111 aa versus 141 aa)
YP_976117.1	integral membrane protein involved in inhibition of the Z-ring formation
YP_976118.1	Differs from Rv0012 by 2aa, E105K, R233C
YP_976119.1	aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity
YP_976120.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase
YP_976122.1	Differs from Rv3913 by 1aa, G57D
YP_976128.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_976129.1	Differs from Rv3920c by 1aa, W110R
YP_976130.1	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_976132.1	protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates
YP_976133.1	in Escherichia coli transcription of this gene is enhanced by polyamines
YP_976134.1	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.
YP_976135.1	binds the polymerase to DNA and acts as a sliding clamp
YP_976136.1	Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_976137.1	Differs from Mb0004 by 1aa, S16L
YP_976138.1	negatively supercoils closed circular double-stranded DNA
YP_976139.1	negatively supercoils closed circular double-stranded DNA
YP_976140.1	Differs from Rv0007 by 1aa, I272V
YP_976141.1	Differs from Rv0008c by 1aa, P145S
YP_976143.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (g-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (111 aa versus 141 aa)
YP_976144.1	integral membrane protein involved in inhibition of the Z-ring formation
YP_976145.1	Differs from Rv0012 by 2aa, E105K, R233C
YP_976146.1	aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity
YP_976151.1	Differs from Rv0018c by 3aa, L3R, A455S, S463P
YP_976153.1	Differs from Mb0020c by 2aa, G47R, Y250H, and from Rv0020c by 3aa, G222D, C298Y, Q378R, and deletion of 6aa (EQRGYP) at position 246
YP_976154.1	Differs from Rv0021c by 1aa, P277A
YP_976157.1	In Mycobacterium tuberculosis strain H37Rv, and other mycobacteria, Rv0024 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0024 into 2 parts
YP_976158.1	Differs from Rv0025 by 1aa, L73P
YP_976159.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 4 bp insertion (*-atcg) leads to a longer protein with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (477 aa versus 448 aa). Differs from Rv0026 by 1aa, P93Q
YP_976162.1	Differs from Rv0029 by 1aa, N190H
YP_976169.1	Differs from Mb0037c and Rv0036c by 1aa, L186P, and at C-terminal end due to frameshift resulting from 1 bp deletion at position equivalent to Mycobacterium tuberculosis H37Rv2, 39228-39228, after codon 202
YP_976172.1	Differs from Rv0039c by 1aa, F24C
YP_976174.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_976179.1	Differs from Mb0047c by 1aa, T120I, and from Rv0046c by 2aa, T120I, G190R
YP_976181.1	Differs from Rv0048c by 1aa, A250V
YP_976183.1	In Mycobacterium bovis BCG Pasteur, insertion of 3 codons after position 632 leads to a slightly longer product compared to its homologs in Mycobacterium tuberculosis strain H37Rv (681 aa versus 678 aa) and Mycobacterium bovis AF2122/97 (681 aa versus 680 aa). In addition, differs from Rv0050 by 1aa, L6P
YP_976186.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_976187.1	binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA
YP_976188.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_976189.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_976191.1	unwinds double stranded DNA; these Mycobacterial enzymes appear to contain inteins
YP_976195.1	Differs from Mb0063 by 1aa, A72D, and from Rv0062 by 2aa, A72D, V106I
YP_976197.1	Differs from Mb0065 by 1aa, T435I, and from Rv0064 by 4aa, T435I, D457G, F550V, P906R
YP_976198.1	Differs from Rv0064A by 1aa,V48A
YP_976200.1	Differs from Rv0066c by 1aa, N117K
YP_976202.1	Differs from Rv0068 by 1aa, L214V
YP_976204.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_976205.1	In Mycobacterium bovis BCG Pasteur, a 45 bp insertion (5 copies of VDP repeat) leads to longer products compared to its homologs in Mycobacterium tuberculosis strain H37Rv (250 aa versus 235 aa) and Mycobacterium bovis (250 aa versus 238 aa)
YP_976207.1	In Mycobacterium tuberculosis strain H37Rv, Rv0073 exists as a single gene as in Mycobacterium bovis BCG Pasteur. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Rv0073 into 2 parts, Mb0074 and Mb0075
YP_976209.1	Differs from Rv0075 and Mb0077 by 1aa, G326D
YP_976212.1	Differs from Rv0078 by 1aa, V113I
YP_976216.1	Differs from Mb0083 by 1aa, C35R, and from Rv0080 by 2aa, C35R, V60G
YP_976218.1	Differs from Rv0082 by 1aa, R74Q
YP_976219.1	In Mycobacterium bovis, a single base transversion (a-t) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (642 aa versus 640 aa). Differs from Mb0086 by 1aa, A177V
YP_976222.1	Differs from Rv0086 by 1aa, T118M
YP_976223.1	Differs from Rv0087 by 1aa, I230V
YP_976228.1	Differs from Rv0092 by 1aa, A3T
YP_976229.1	Differs from Rv0093c by 1aa, R22C
YP_976230.1	Differs from Rv0094c by 3aa, D256E, W296R, K315E
YP_976231.1	In Mycobacterium tuberculosis strain H37Rv, Rv0095c and Rv1588 exist as separate genes in their respective positions. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 73 bp substitution leads to a single combined gene. Differs from Rv0095c by 5aa, E57D, T70S, V85A, V91G, A92Q
YP_976232.1	Differs from Rv0096 by 1aa, W182R
YP_976235.1	activates fatty acids by binding to coenzyme A
YP_976239.1	Differs from Rv0103c by 1aa, S22L
YP_976241.1	required for 70S ribosome assembly
YP_976243.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-t) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; differs from Rv0107c by 3aa, V136A, P1247S, S1327A
YP_976245.1	Differs from Rv0109 by 1aa, G346R
YP_976249.1	catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate
YP_976250.1	Differs from Rv0114 by 1aa, R121G
YP_976251.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-c) equivalent to Mycobacterium tuberculosis H37Rv position 139559, leads to shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. In addition, in Mycobacterium bovis, a single base insertion, at position equivalent to 138823, leads to a different NH2 part
YP_976254.1	catalyzes the formation of formyl-CoA from oxalyl-CoA
YP_976255.1	activates fatty acids by binding to coenzyme A
YP_976256.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_976260.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 180 bp insertion leads to a longer product in the 3' direction compared to its homolog in Mycobacterium tuberculosis strain H37Rv (538 aa versus 487 aa)
YP_976263.1	Differs from Rv0127 by 1aa, P18S
YP_976268.1	Differs from Rv0132c by 1aa, E147K
YP_976269.1	In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis AF2122/97, codon 161 is TAC and in Mycobacterium bovis BCG Pasteur, TAA
YP_976272.1	this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress
YP_976273.1	Differs from Mb0143 by 1aa, D96G
YP_976274.1	Differs from Rv0139 by 1aa, R227H
YP_976278.1	Differs from Rv0143c by 1aa, L34F
YP_976286.1	Differs from Rv0151c by 1aa, R26G
YP_976288.1	Differs from Rv0153c by 1aa, G105D
YP_976291.1	Differs from Rv0156 by 1aa, C2Y
YP_976294.1	Differs from Rv0159c by 1aa, T255P
YP_976295.1	Differs from Rv0160c by 2aa, T116A, T211A
YP_976297.1	Differs from Rv0162c and Mb0167c by 1aa, R41H
YP_976300.1	In Mycobacterium tuberculosis strain H37Rv, Rv0165c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a 2 bp insertion (*-cc) leads to a product with a different COOH terminus
YP_976301.1	activates fatty acids by binding to coenzyme A
YP_976304.1	Differs from Rv0169 by 2aa, A313S, S359P; Differs from Rv0169 by 2aa, A313S, S359P
YP_976305.1	Differs from Rv0170 by 1aa, T179I
YP_976306.1	Differs from Rv0171 by 1aa, D212E
YP_976309.1	Differs from Rv0174 by 1aa, P370L
YP_976311.1	Differs from Mb0182 by 1aa, S285N, and from Rv0176 by 3aa, S285N, S290Q, A291S
YP_976314.1	Differs from Rv0179c by 1aa, H124R
YP_976317.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
YP_976321.1	Differs from Mb0192 by 1aa, S504I, and from Rv0186 by 2aa, S504I, R532P
YP_976322.1	Differs from Rv0187 and Mb0193 by 1aa, V147A
YP_976324.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_976327.1	In Mycobacterium tuberculosis strain H37Rv, Rv0192 and Rv0192A exist as 2 genes with an overlap region. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-g) leads to a single product. Differs from Mb0198 by 1aa, A279V and from Rv0192 by 2aa, P113S, A279V
YP_976328.1	Differs from Rv0193c and Mb0199c by 1aa, E417K
YP_976329.1	Differs from Mb0200 by 1aa, I49V, and from Rv0194 by 2aa, T74M, M223T
YP_976332.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transversion (t-g) introduces a stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (748 aa versus 762 aa). Differs from Rv0197 by 1aa, S378R
YP_976338.1	Differs from Rv0203 and Mb0209 by 1aa, T88K
YP_976339.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, the presence of a more likely start codon leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (427 a versus 412 aa). Differs from Rv0204c by 1aa, L321V
YP_976340.1	Differs from Rv0205 by 1aa, R72H
YP_976341.1	Differs from Rv0206c by 2aa, I384F, E466D
YP_976343.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_976344.1	Differs from Rv0209 by 1aa, A162V
YP_976345.1	Differs from Rv0210 by 1aa, T486A
YP_976346.1	catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP
YP_976349.1	activates fatty acids by binding to coenzyme A
YP_976350.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 29 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (388 aa versus 357 aa). Differs from Mb0221c by 1aa, S361A
YP_976352.1	Differs from Rv0217c by 1aa T184P
YP_976353.1	Differs from Rv0218 by 2aa, R316C, N413D
YP_976356.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, RD10, a 1902 bp deletion leads to a shorter product with a different COOH part, compared to its homolog in Mycobacterium tuberculosis strain H37Rv (257 aa versus 469 aa). It also leads to the deletion of the next protein, echA1 (Rv0222)
YP_976357.1	In mycobacterium bovis strain AF2122/97 and Mycobacterium bovis BCG Pasteur, RD10, a 1902 bp deletion, compared to Mycobacterium tuberculosis H37Rv, truncates Rv0221c and Rv0223c and removes Rv0222c; In Mycobacterium bovis BCG Pasteur, a single base deletion at position equivalent to Mycobacterium tuberculosis H37Rv2 267419-267419(*-c) splits gene into two parts compared to its homologs in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis AF2122/97 (116 aa and 269 aa, versus 487 aa and 385 aa, respectively. Also has same 1 bp insertion, as Mycobacterium bovis AF2122/97, at position equivalent to Mycobacterium tuberculosis H37Rv2 base 266743. Deletion in Mycobacterium bovis and bovis BCG Pasteur of region RD10 leads to a different COOH part compared to Mycobacterium tuberculosis strain H37Rv. May be pseudogene
YP_976358.1	In Mycobacterium bovis BCG Pasteur, a single base deletion at position equivalent to Mycobacterium tuberculosis H37Rv2 267419-267419(*-c) splits gene into two parts compared to its homologs in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis AF2122/97 (116 aa and 269 aa, versus 487 aa and 385 aa, respectively. Also has same 1 bp insertion, as Mycobacterium bovis AF2122/97, at position equivalent to Mycobacterium tuberculosis H37Rv2 base 266743. May be pseudogene
YP_976359.1	Differs from Rv0224c by 1aa, L117F
YP_976362.1	Differs from Rv0227c by 1aa, R29S, and from Mb0232c by 1aa, S392N
YP_976365.1	Differs from Rv0230c by 1aa, E199D
YP_976368.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_976369.1	NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate
YP_976371.1	Differs from Rv0236c by 3aa, V412M, A990T, G1080S
YP_976373.1	Differs from Rv0237 by 1aa, L129V
YP_976376.1	Differs from Rv0240 by 1aa, S31A
YP_976378.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_976379.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_976380.1	Differs from Mb0250c by 1aa, N503D and from Rv0244c by 3aa, R394K, A479E, N503D
YP_976382.1	Differs from Rv0246 by 1aa, A129V
YP_976383.1	catalyzes the fumarate and succinate interconversion; fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source
YP_976384.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol
YP_976391.1	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
YP_976393.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transition (c-t) leads to a truncated product in the 5' direction compared to Mycobacterium tuberculosis strain H37Rv (72 aa versus 124 aa)
YP_976395.1	Differs from Rv0259c by 1aa, V182A
YP_976396.1	catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane
YP_976401.1	Differs from Rv0265c and Mb0271c by 1aa, C313Y
YP_976406.1	activates fatty acids by binding to coenzyme A
YP_976408.1	Differs from Mb0278c by 1aa, P164L
YP_976411.1	Differs from Rv0275c by 1aa, L24S
YP_976414.1	Differs by 1 aa, Q24* from Rv0227A and Mb0351A
YP_976415.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS3 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovs BCG Pasteur, a large insertion leads to an extra copy of PE_PGRS3. Also, a frameshift due to single base deletion (t-*), splits this extra copy of PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b. Also differs from Mb0285c by an insertion of 144bp
YP_976416.1	In Mycobacterium bovis BCG Pasteur, a insertion of 66 bp lead to a longer product than to the homolog Mycobacterium bovis (899 aa versus 877 aa). In Mycobacterium bovis, 2 deletions, one of 18 bp and the other of 66 bp, and part of a 2780 bp insertion , leads to a shorter product with a different 3' end compared to its homolog in Mycobacterium tuberculosis strain H37Rv (877 aa versus 957 aa)
YP_976417.1	In Mycobacterium bovis BCG Pasteur, 2 insertions each of 9 bp and a deletion of 9bp, lead to a longer product compared to its homolog in Mycobacterium bovis (834 aa versus 831 aa). In Mycobacterium bovis, 2 deletions each of 9 bp (ccgccggcg-* and cccgccggc-*), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (831 aa versus 837 aa)
YP_976418.1	Differs from Rv0280 by 1 aa P337S
YP_976420.1	Differs from Rv0282 by 1aa, A6E
YP_976422.1	Differs from Mb0292 by 1aa, A134T, and from Rv0284 by 2aa, A134T, R214P
YP_976428.1	Differs from Rv0290 by 1aa, T400A
YP_976430.1	Differs from Rv0292 by 1aa, D217N
YP_976431.1	Differs from Rv0293c and Mb0301c by 1aa, S263G
YP_976432.1	catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate
YP_976435.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (606 aa versus 591 aa)
YP_976437.1	Differs from Mb0307 by 1aa, S13N
YP_976440.1	Differs from Mb0310 by 1aa A124V
YP_976442.1	In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (g-*) leads to a shorter CDS (Mb0312c and BCG_0344c) equivalent to the 3' end of Rv0304c/PPE5. Differs from Rv0304c by 3aa, S481G, F708S, A955T, and 5 codon in-frame deletion at position 503
YP_976443.1	In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (t-*) resulting in the absence of a stop codon leads to a longer product. The second part of this CDS shares homology with the 5' end of Rv0304c/PPE5. Differs from Mb0313c by in-frame deletion of 10 codons
YP_976450.1	Differs from Rv0312 by 2aa, G159S, L563P
YP_976452.1	Differs from Rv0314c by 1aa, A184V
YP_976453.1	Differs from Rv0315 by 1aa, T260K
YP_976456.1	Differs from Rv0318c by 1aa, A223G
YP_976457.1	catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline
YP_976459.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_976461.1	Differs from Rv0323c by 1aa, G142S
YP_976462.1	Differs from Rv0324 by 1aa, A168T
YP_976463.1	In Mycobacterium tuberculosis strain H37Rv, Rv0325 and Rv0326 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, the absence of a stop codon between Rv0325 and Rv0326 due to a single base transition (t-c) leads to single product
YP_976464.1	Differs from Rv0327c by 1aa, Y100H
YP_976466.1	Differs from Rv0329c by 1aa, S129W
YP_976469.1	Differs from Rv0332 by 1aa, G198E
YP_976472.1	Differs from Rv0335c and Mb0340 by 1aa P131T
YP_976473.1	Differs from Rv0336 by 1aa, H496P
YP_976474.1	broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor
YP_976475.1	Differs from Rv0338c by 2aa, G506R, V621A
YP_976479.1	Differs from by 2aa, S88N, Q481H
YP_976482.1	In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv in Mycobacterium bovis BCG Pasteur
YP_976487.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_976488.1	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_976489.1	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_976491.1	In Mycobacterium tuberculosis strain H37Rv, PPE7 and PPE8 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 2 bp insertion (*-ta) resulting in the absence of a stop codon between the 2 genes, leads to a single product, and an altered C-terminus
YP_976493.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_976495.1	Differs from Rv0359 by 1aa, T252A
YP_976498.1	Differs from Rv0362 by 1aa, V292A
YP_976499.1	catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate
YP_976500.1	Differs from Rv0364 by 1aa, L193I
YP_976504.1	Differs from Rv0368c by 1aa, H249R, and from Mb0375c by 1aa, G371S
YP_976506.1	Differs from Rv0370c by 1aa, E201G
YP_976508.1	Differs from Rv0372c by 1aa, G161S
YP_976509.1	Differs from Rv0373c by 1aa, S122F
YP_976513.1	Differs from Rv0377 by 1aa, R302P
YP_976518.1	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_976522.1	Differs from Mb0393 by 1aa, D902A
YP_976523.1	In Mycobacterium tuberculosis strain H37Rv, Rv0388c and Rv0387c exist as 2 separate genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, 3 different base substitutions, the first of 14 bases, the second of 8 bases (tctacagt-gctacagg), and lastly of 28 bases, leads to a longer single product; Differs from Mb0394c by 1aa, T361A
YP_976524.1	non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis
YP_976527.1	Differs from Rv0392c by 1aa, A241V
YP_976530.1	Differs from Rv0395 by 1aa, A80V
YP_976537.1	In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b
YP_976538.1	In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b; Differs from Rv0402c by 1aa, P451L
YP_976540.1	activates fatty acids by binding to coenzyme A
YP_976541.1	In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to single base insertion (*-g) splits pks6 into 2 parts, pks6a and pks6b
YP_976542.1	In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis, a frameshift due to single base insertion (*-g), splits pks6 into 2 parts, pks6a and pks6b; Differs from Mb0413 by 1aa, M921V
YP_976545.1	catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate
YP_976546.1	AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA
YP_976549.1	Differs from Rv0412c by 1aa, Y355D
YP_976551.1	Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate
YP_976552.1	Differs from Rv0415 by 1aa, A158V
YP_976553.1	with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate
YP_976554.1	functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate
YP_976556.1	Differs from Rv0419 by 2aa, T73A, T297A, and from Mb0427 by 1aa, T73A
YP_976557.1	Differs from Rv0420c by 1aa, G21E
YP_976559.1	catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine
YP_976560.1	required for the synthesis of the hydromethylpyrimidine moiety of thiamine
YP_976562.1	Differs from Rv0425c by 1aa, A222E
YP_976565.1	Differs from Rv0428c by 1aa G149D
YP_976566.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_976568.1	Differs from Rv0431 by 2aa, G38V, A87T
YP_976570.1	ATP-dependent carboxylate-amine ligase
YP_976571.1	Differs from Rv0434 by 1aa, A190T
YP_976573.1	Differs from Rv0436c by 1aa, V167G
YP_976574.1	catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine
YP_976575.1	Differs from Rv0438c by 1aa, I15M
YP_976577.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_976579.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transition (g-a) creates an in-frame stop at codon 8, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (479 aa versus 487 aa). Differs from Mb0450c by 1aa, T214K, and from Rv0442c by 2aa, E23K, T214K
YP_976581.1	Differs from Rv0444c by 2aa, D107G, E184G
YP_976582.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins
YP_976587.1	Differs from Mb0458c by 1aa, A314T
YP_976593.1	catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_976595.1	In Mycobacterium bovis and in Mycobacterium bovis BCG, a possible RBS upstream leads to an earlier start resulting in a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (676 aa versus 673 aa)
YP_976600.1	E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component
YP_976603.1	Differs from Rv0465c by 2aa, D36N, R106C, and from Mb0474c by 1aa, R326Q
YP_976606.1	converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA
YP_976611.1	Differs from Rv0472c and Mb0482c by 1aa, D162G
YP_976612.1	Differs from Rv0473 by 1aa, R5K
YP_976617.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate
YP_976619.1	In Mycobacterium bovis, a 56 bp deletion results in a different NH2 part and leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (311 aa versus 340 aa)
YP_976621.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_976623.1	Differs from Rv0484c by 1aa, L140I
YP_976628.1	2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate
YP_976629.1	Differs from Rv0490 and Mb0500 by 1aa, S109F
YP_976630.1	Differs from Rv0491 and Mb0501 by 1aa, T18A
YP_976631.1	Differs from Rv0492c by 1aa, F520L
YP_976633.1	Differs from Rv0493c by 1aa, G174S
YP_976640.1	catalyzes the formation of L-proline from pyrroline-5-carboxylate
YP_976648.1	Differs from Mb0519 by 1aa, D119H, and from Rv0507 by 3aa, H426R, Y509D, C722S
YP_976650.1	catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins
YP_976651.1	transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis
YP_976653.1	catalyzes the formation of porphobilinogen from 5-aminolevulinate
YP_976655.1	Differs from Mb0527 and Rv0514 by 1aa, G23A
YP_976658.1	Differs from Rv0517 by 1aa, G394D
YP_976665.1	Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway
YP_976673.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS6 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-t) splits PE_PGRS6 into 2 parts, PE_PGRS6a and PE_PGRS6b, resulting in PE_PGRS6a having a different COOH part. There is also a 84 bp and a 9 bp (*-cggggccgg) insertion in PE_PGRS6a
YP_976674.1	FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
YP_976675.1	catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate
YP_976676.1	Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate
YP_976679.1	Differs from Rv0538 by 1aa, P228R
YP_976682.1	Differs from Rv0541c by 1aa, V226I
YP_976686.1	Differs from Rv0545c by 1aa, S49P
YP_976689.1	catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA
YP_976690.1	In Mycobacterium tuberculosis strain H37Rv, Rv0549c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv0549c into 2 parts
YP_976692.1	activates fatty acids by binding to coenzyme A
YP_976693.1	Differs from Rv0552 and Mb0567 by 1aa, T144I
YP_976694.1	catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate
YP_976696.1	SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis
YP_976697.1	Differs from Rv0556 by 1aa, R15L
YP_976699.1	Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone
YP_976704.1	metalloprotease
YP_976705.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_976707.1	nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription
YP_976708.1	Differs from Rv0567 by 1aa, L201F
YP_976709.1	Differs from Rv0568 and Mb0583 by 1aa, E120G
YP_976711.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_976712.1	Differs from Rv0571c and Mb0586c by 1aa, L258F
YP_976713.1	Differs from Rv0572c by 1aa, L31F
YP_976714.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate
YP_976715.1	Differs from Rv0574c by 1aa, K4N
YP_976716.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base insertion (*-c) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_976717.1	Differs from Rv0576 by 1aa, H233R
YP_976719.1	Differs from Rv0578c and from Mb0593c by 3aa, there are deleted in Mycobacterium BCG bovis Pasteur
YP_976725.1	Differs from Rv0584 by 1aa G90D
YP_976726.1	Differs from Rv0585c by 1aa V438I and from Mb0600c by 2aa M150I and V438I
YP_976730.1	Differs from Rv0589 by 1aa S51F
YP_976731.1	In Mycobacterium tuberculosis strain H37Rv, mce2B and Rv0590A are 2 genes, most likely to be linked. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, an in-frame insertion of a single base (*-g) leads to a single product
YP_976732.1	Differs from Rv0591 by 2aa M49T and N398T
YP_976733.1	In Mycobacterium tuberculosis strain H37Rv, mce2D exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift occurs in a strech of C (7 for H37Rv, 8 for Mycobactrium bovis and 9 for Mycobacterium bovis BCG). This leads to mceDa genes with different COOH parts and a remnant mc2Db pseudogene
YP_976734.1	In Mycobacterium bovis, a single base transition (c-t) introducing a stop codon, leads to the formation of a truncated product compared to its homolog in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur (188 aa versus 402 aa)
YP_976743.1	Differs from Rv0602c by 1aa I28V
YP_976744.1	Differs from Mb0619 by 2aa P77A and E96K
YP_976745.1	Differs from Rv0604 by 1aa P180S
YP_976752.1	Differs from Rv0610c by 1aa S103N
YP_976761.1	In Mycobacterium tuberculosis strain H37Rv, galT is split into 2 parts, galT' and 'galT. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, an in-frame insertion of a single base (*-a) leads to a single product.Differs from Mb0635 by 1aa R183G and from Rv0619 by 1aa A397T
YP_976762.1	catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism
YP_976763.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a single base transition (a-g) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (385 aa versus 354 aa)
YP_976771.1	Differs from Rv0629c by 1aa A536T
YP_976772.1	In Mycobacterium tuberculosis strain H37Rv, recB exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (g-*) splits recB into 2 parts, recBa and recBb. Differs from Mb0647c by 1aa H514R and from Rv0630c by 3aa L74V, H514R and F811V
YP_976773.1	Differs from Rv0631c by 1aa E329G and from Mb0648c by 1aa P858L
YP_976774.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_976775.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 9 bp deletion (cgggtgcgc-*) leads to shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (276 aa versus 279 aa)
YP_976778.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif
YP_976779.1	functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II
YP_976780.1	functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II
YP_976781.1	functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II
YP_976782.1	forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_976783.1	Modulates Rho-dependent transcription termination
YP_976784.1	binds directly to 23S ribosomal RNA
YP_976785.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_976786.1	Differs from Rv0642c by 1aa L95F
YP_976788.1	differs from Rv0644c by 1aa L114R
YP_976791.1	Differs from Rv0647c by 1aa T293A
YP_976792.1	Differs from Rv0648 by 1aa L200S
YP_976795.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_976796.1	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_976802.1	Differs from Rv0658c by 1aa P75L
YP_976807.1	Differs from Rv0663 by 1aa G349D
YP_976811.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_976812.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_976813.1	Differs from Rv0669c by 1aa P146S
YP_976814.1	Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues
YP_976817.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_976819.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_976820.1	Differs from Rv0676c by 2aa I793T and V948I
YP_976826.1	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_976827.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_976828.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_976829.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_976830.1	Differs from Rv0686 by 1aa S82I
YP_976831.1	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_976842.1	In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718
YP_976843.1	In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718
YP_976845.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_976846.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_976847.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_976848.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_976849.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_976850.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_976851.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_976852.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_976853.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_976854.1	one of the stabilizing components for the large ribosomal subunit
YP_976855.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_976856.1	In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur, atsA exists as a single gene. In Mycobacterium bovis, a single base transversion (g-t), introducing a stop codon, splits atsA into 2 parts, atsAa and atsAb
YP_976859.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_976860.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_976861.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_976862.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif
YP_976863.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_976864.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_976865.1	binds 5S rRNA along with protein L5 and L25
YP_976866.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_976867.1	L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7
YP_976868.1	late assembly protein
YP_976872.1	catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate
YP_976873.1	Differs from Rv0728c by 1aa H242R
YP_976874.1	Differs from Rv0729 by 2aa P134L and S439
YP_976877.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_976878.1	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_976879.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn
YP_976880.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein regulates polyketide synthases and secreted or membrane proteins
YP_976884.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 2 bp insertion (*-cg) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (282 aa versus 268 aa)
YP_976891.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, two 48 bp deletions, and a 138 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (797 aa versus 783 aa). Differs from Mb0767 by 1aa S597N
YP_976892.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, insertions of 168 bp and 105 bp, a 11 bp for 71 bp substitution, and a 9 bp deletion (cggcaacgg-*), leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (909 aa and 893 aa versus 801 aa). In addition, in Mycobacterium bovis BCG Pasteur, a 48 bp deletion compared to Mycobacterium bovis and Mycobacterium tuberculosis strain H37Rv occurs
YP_976898.1	Differs from Rv0752c by 2aa A69V and V186I
YP_976899.1	Differs from Mb0775c by 1aa V442G
YP_976901.1	Differs from Rv0755c by 1aa K545R
YP_976905.1	Differs from Rv0755c by 2aa I71G, L172P
YP_976916.1	Differs from Rv0769 by 1aa V55A
YP_976917.1	Differs from Mb0793 by 1aa V126G
YP_976919.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_976921.1	Differs from Rv0774c by 1aa A219S and from Mb0797c by 1aa D142A
YP_976924.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_976927.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_976928.1	In Mycobacterium tuberculosis strain H37Rv, ptrB is split into 2 genes, ptrBa and ptrBb, due to a frameshift. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 2 bp insertion (*-gc) leads to a single product
YP_976931.1	In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (t-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808
YP_976932.1	In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis,and Mycobacterium bovis BCG Pasteur a frameshift due to a single base deletion (t-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808
YP_976934.1	Differs from Rv0787 by 1aa H269Y
YP_976935.1	With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway
YP_976936.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_976942.1	In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (a-*) splits Rv0794c into 2 parts
YP_976943.1	In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (a-*) splits Rv0794c into 2 parts
YP_976944.1	Differs from Rv0797 by 1aa L111M
YP_976947.1	catalyzes the removal of amino acids from the N termini of peptides
YP_976950.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_976955.1	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_976956.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_976959.1	catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate
YP_976965.1	Differs from Rv0818 by 1aa P97L
YP_976967.1	In Mycobacterium tuberculosis strain H37Rv and Mycobacterium Bovis phoT exists as a single gene. In Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (g-*), splits phoT into to parts phoTa and phoTb. Differs from Rv0820 by 1aa L35F
YP_976969.1	Differs from Rv0822c by 1aa P89H
YP_976970.1	Differs from Rv0823c by 2aa C130G and L330F
YP_976973.1	Differs from Rv0826 by 1aa Q294R and Mb0849 by 1aa E97G
YP_976976.1	Differs from Rv0829 by 1aa G80A
YP_976979.1	In Mycobacterium bovis BCG Pasteur PE-PGRS13 exists as a single gene. In Mycobacterium tuberculosis and Mycobacterium bovis, it is splitted in 2 genes PE-PGRS12 and PE-PGRS13
YP_976980.1	In Mycobacterium bovis, deletions of 143 bp and 9 bp (cgccgttgc-*), leads to a shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur (831 aa versus 882 aa)
YP_976981.1	Differs from Rv0835 by 1aa G162D
YP_976982.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a single base transition (a-g) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (240 aa versus 217 aa)
YP_976984.1	In Mycobacterium bovis, a 6bp insertion (*-cggccc) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (258 aa versus 256 aa). In Mycobacterium bovis BCG Pasteur, a 12bp insertion (compared to its homolog in Mycobacterium tuberculosis strain H37Rv) and a 6bp insertion (compared to its homolog in Mycobacterium bovis) leads to an even longer product (260 aa)
YP_976987.1	Differs from Rv0841 by 1aa F29V
YP_976989.1	Differs from Rv0843 by 1aa G191D and from Mb0866 by 1aa A309D
YP_976990.1	Differs from Mb0867c by 1aa A73P
YP_976991.1	Differs from Rv0845 by 1aa E219A
YP_976992.1	Differs from Mb0869c by 1aa Y411H
YP_976993.1	Differs from Rv0847 by 1aa V128A
YP_976994.1	Differs from Rv0848 by 1aa S93G, and from Mb0871 by 1aa V137G
YP_976997.1	Differs from Rv0851c by 1aa G59S and from Mb0874c by 1aa V84F
YP_977005.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_977006.1	Differs from Rv0860 by 1aa T701A
YP_977007.1	Differs from Rv0861c by 1aa A258V
YP_977008.1	Differs from Rv0862c by 2aa F224L and S749L, and from Mb0885c by 1aa F224L
YP_977010.1	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis
YP_977013.1	In Mycobacterium bovis, a 240 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur (327 aa versus 407 aa). Differs from Rv0867c by 1aa E235D
YP_977015.1	together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z
YP_977016.1	Differs from Mb0894c by 1aa G29S
YP_977018.1	In Mycobacterium bovis BCG Pasteur, a 9 bp in-frame insertion (compared to Mycobacterium tuberculosis strain H37Rv), leads to a lightly longer product (609 aa versus 606 aa). In Mycobacterium bovis, an additional 3 bp in-frame deletion (compared to Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur) leads to a product of 608 aa
YP_977022.1	Differs from Mb0900c by 1aa D26G
YP_977024.1	In Mycobacterium bovis and Mycobaterium bovis BCG Pasteur, a single base deletion (a-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (438 aa versus 443 aa). Differs from Rv0878c and Mb0902c by 1aa K436Q
YP_977030.1	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate
YP_977035.1	forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle
YP_977036.1	Differs from Rv0890c by 1aa A866P
YP_977037.1	Differs from Rv0891c by 1aa G37V
YP_977042.1	type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH
YP_977051.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_977053.1	In Mycobacterium bovis BCG Pasteur and in Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Rv0907 by 1aa, L322P
YP_977055.1	Differs from Rv0909 by 1aa, Q45H
YP_977059.1	Differs from Rv0913c by 1aa P233L
YP_977060.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_977064.1	Differs from Rv0918 by 1aa, G46S
YP_977066.1	Differs from Rv0920c by 1aa, E249D
YP_977070.1	In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur, Rv0924c and Rv0925c exist as 2 genes. In Mycobacterium bovis, a single base deletion (t-*) leads to a single product, Mb0948c. Differs from Rv0924c by 1aa, A216P
YP_977071.1	In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur, Rv0924c and Rv0925c exist as 2 genes. In Mycobacterium bovis, a single base deletion (t-*) leads to a single product,Mb0948c
YP_977076.1	Differs from Rv0930 by 1aa, T5M
YP_977077.1	In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-t) splits pknD into 2 parts, pknDa and pknDb
YP_977078.1	In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-t) splits pknD into 2 parts, pknDa and pknDb
YP_977079.1	Differs from Rv0932c by 1aa, A115S
YP_977080.1	In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base insertion (*-t, position 1041448-1041449) splits pstB into 2 parts, pstBa and pstBb
YP_977081.1	In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base insertion (*-t, position 1041448-1041449) splits pstB into 2 parts, pstBa and pstBb
YP_977082.1	Differs from Rv0934 by 1aa, A352V
YP_977086.1	catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA and has been shown to have polymerase activity
YP_977093.1	Differs from Rv0945 by 1aa, G180R
YP_977094.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_977099.1	catalyzes the interconversion of succinyl-CoA and succinate
YP_977100.1	Catalyzes the only substrate-level phosphorylation in the TCA cycle
YP_977101.1	Differs from Rv0953c and Mb0978c by 1aa, A50T
YP_977104.1	glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate
YP_977105.1	involved in de novo purine biosynthesis
YP_977106.1	Differs from Rv0958 by 1aa, P274S
YP_977111.1	Differs from Rv0962c by 1aa, L186P
YP_977112.1	Differs from Rv0963c and Mb0988c by 1aa, S258G
YP_977113.1	Differs from Rv0964c by 1aa, T124P
YP_977114.1	Differs from Rv0965c by 1aa, H94R
YP_977115.1	Differs from Rv0966c by 2aa, A175V, G186W
YP_977118.1	Differs from Rv0969 by 1aa, N484D
YP_977120.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_977121.1	Differs from Rv0972c by 1aa, H236Q
YP_977122.1	Differs from Rv0973c by 1aa, F220I
YP_977123.1	Differs from Rv0974c by 1aa, K51N
YP_977124.1	In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG pasteur
YP_977127.1	In Mycobacterium bovis and in Mycobacterim bovis BCG Pasteur, a 115 bp to 127 bp substitution leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (335 aa versus 331 aa)
YP_977129.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_977130.1	Differs from Rv0980c by 1aa, Q43H, and from Mb1006c by 1aa, A270T
YP_977131.1	Differs from Rv0981 by 1aa, S70G
YP_977132.1	Differs from Rv0982 by 1aa, H339L
YP_977133.1	Differs from Rv0983 by 1aa, P390L
YP_977135.1	forms homopentamer; channel that opens in response to pressure or hypoosmotic shock
YP_977136.1	Differs from Rv0986 by 1aa, L228V
YP_977137.1	In Mycobacterium bovis BCG Pasteur and Mycobacterium tuberculosis strain H37Rv, Rv0987 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a stop codon that splits Rv0987 in two parts, Mb1013 and Mb1014. Differs from Rv0987 by 1aa, V717F
YP_977138.1	Differs from Rv0988 by 2aa, I57V, D135Y
YP_977139.1	Differs from Rv0989c by 1aa, V321I
YP_977140.1	Differs from Rv0990c by 1aa, A54S
YP_977142.1	Differs from Rv0992c by 2aa, I3M, S135G, and from Mb1019c by 1aa, S135G
YP_977143.1	Differs from Rv0993 by 1aa, R235Q
YP_977144.1	Differs from Rv0994 by 1aa, G230C
YP_977146.1	Differs from Rv0996 by 1aa, D92G, and from Mb1023 by 1aa, D92G
YP_977153.1	catalyzes the degradation of arginine to citruline and ammonia
YP_977154.1	Differs from Rv1002c by 1aa, L115V
YP_977157.1	catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine
YP_977158.1	Differs from Rv1006 by 1aa, S535P, and from Mb1033 by 1aa, N25S
YP_977159.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_977160.1	Differs from Rv1008 by 1aa, N186T
YP_977161.1	Differs from Rv1009 by 2aa, E282G, V357A
YP_977162.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_977163.1	catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis
YP_977164.1	In Mycobacterium tuberculosis strain H37Rv, Rv1012 exists as a single gene. In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a different NH2 terminus. Differs from Rv1012 by 1aa, N65S
YP_977165.1	activates fatty acids by binding to coenzyme A
YP_977166.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_977167.1	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response
YP_977168.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a 5 bp deletion (cacgc-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_977169.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_977170.1	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_977173.1	functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era
YP_977174.1	Differs from Rv1022 by 1aa, P33T
YP_977175.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_977180.1	Differs from Rv1028c by 3aa, S83P, D295G, S368P, and from Mb1056c by 1aa, S83P
YP_977182.1	catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_977183.1	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_977184.1	one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex
YP_977190.1	Differs from Rv1037c by 1aa, L20Q
YP_977192.1	Differs from Rv1039c and Mb1068c by 1aa, K175N
YP_977194.1	Differs from Rv1042c by 1aa, E129G
YP_977195.1	Differs from Rv1043c by 1aa, T99A, and from Mb1072c by 1aa, G263C
YP_977197.1	Differs from Mb1074 by 1aa, W104G
YP_977198.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a 1bp insertion, compared to Mycobacterium tuberculosis strains H37Rv, leads to different C-terminus
YP_977200.1	Differs from Rv1048c and Mb1077c by 2aa, A37D, T173A
YP_977210.1	activates fatty acids by binding to coenzyme A
YP_977219.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, 2 deletions each of 3 bp (ccg-* and cgc-*) and a 18 bp insertion leads to a longer product compared to their homolog in Mycobacterium tuberculosis strain H37Rv (671 aa versus 667 aa)
YP_977220.1	In Mycobacterium bovis, insertions of 717 bp and 192 bp, and a 9 bp (tccgctgcc-*) deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (763 aa versus 463 aa). In Mycobacterium bovis BCG Pasteur a deletion of 99 bp leads to a smaller product compared to the homolog in Mycobacterium bovis (730 aa versus 763 aa)
YP_977221.1	Differs from Rv1069c and from Mb1098c by 1aa L481P
YP_977222.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_977223.1	catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA
YP_977226.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_977230.1	Differs from Rv1078 by 1aa T171I
YP_977231.1	catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine
YP_977232.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_977239.1	In Mycobacterium bovis BCG Pasteur, insertions of 144 bp and 3bp, and deletion of 42 bp, lead to a longer product compared to the homolog in Mycobacterium bovis (809 aa versus 774 aa). In Mycobacterium bovis, insertions of 3 bp (*-gcg) and 45 bp, and deletions of 18 bp and 9 bp (ggtggggcc-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (774 aa versus 767 aa)
YP_977242.1	Differs from Rv1089 and Mb1118 by 1 aa N84T
YP_977245.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 9 bp deletion (ccggcggca-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (850 aa versus 853 aa)
YP_977246.1	catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis
YP_977247.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_977250.1	Differs from Rv1096 by 1aa, S272P
YP_977251.1	Differs from Rv1097c by 1aa, L23P
YP_977252.1	class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_977253.1	type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese
YP_977254.1	Differs from Rv1100 and Mb1130 by 1aa, P21T
YP_977255.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (t-*) leads to a shorter product with a different amino part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Mb1131c by 1 aa, E315D
YP_977256.1	Differs from Rv1102c by 1aa, I65T
YP_977261.1	catalyzes the bidirectional exonucleolytic cleavage of DNA
YP_977262.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_977263.1	Differs from Rv1109c and Mb1139c by 1aa, T147A
YP_977264.1	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_977266.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_977269.1	Differs from Rv1115 by 1aa, P19S
YP_977275.1	Differs from Mb1151c by 1aa, G53A
YP_977276.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_977277.1	similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate
YP_977280.1	Differs from Rv1125 by 1aa, G101S
YP_977282.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_977283.1	Differs from Rv1128c by 1aa, G270E
YP_977285.1	Differs from Rv1130 by 2aa, G3D, L10F
YP_977286.1	catalyzes the formation of citrate from acetyl-CoA and oxaloacetate
YP_977287.1	Differs from Mb1163 by 1aa, T176M
YP_977288.1	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine
YP_977297.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_977298.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_977301.1	In Mycobacterium tuberculosis strain H37Rv, Rv1145 and Rv1146 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-a) at H37Rv position 1273250-1273251 leads to a single product
YP_977303.1	Differs from Rv1148c and Mb1179c by 1aa, N354H
YP_977305.1	Modulates the activities of several enzymes which are inactive in their acetylated form
YP_977307.1	Differs from Rv1153c by 2aa, T36A, G53D
YP_977308.1	Differs from Rv1154c by 1aa, A123T
YP_977309.1	Differs from Rv1155 by 1aa, P115S
YP_977311.1	Is 24 codons shorter than Rv1157c and Mb1188c due to 72bp deletion at position equivalent to H37Rv, 1283458-1283529. After codon 214
YP_977313.1	involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis
YP_977314.1	4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction
YP_977316.1	Differs from Rv1161 by 2aa, L458V, G821D
YP_977318.1	Differs from Rv1163 and Mb1195 by 1aa, L106P
YP_977319.1	Differs from Rv1164 by 1aa, V200A
YP_977323.1	In Mycobacterium tuberculosis strain H37Rv, PPE17 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and in Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits PPE17 into 2 parts, PPE17a and PPE17b
YP_977327.1	Differs from Rv1172c by 1aa, H133Q
YP_977328.1	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis
YP_977330.1	Differs from Rv1175c by 3aa, N90T, S210T, S649I
YP_977333.1	catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis
YP_977335.1	In Mycobacterium tuberculosis strain H37Rv, Rv1180 and Rv1181 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transversion (a-c) leads to a single product (similar to other organisms). Differs from Rv1181 by 2aa, A1068D, P1423A
YP_977339.1	activates fatty acids by binding to coenzyme A
YP_977340.1	Differs from Rv1186c by 1aa, A207P
YP_977343.1	member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription
YP_977345.1	activates fatty acids by binding to coenzyme A
YP_977348.1	In Mycobacterium bovis, a 14 bp to 11 bp substitution leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (390 aa versus 391 aa). Differs extensively from orthologs Mb1228 and Rv1196 due to numerous substitutions and transitions. Region from aa 210 - 260 shows most difference
YP_977349.1	Differs from Mb1229 by 1aa, A58T
YP_977350.1	Differs from Rv1198 by 1aa, D12A
YP_977351.1	Differs from Rv1199c and Mb1231c by 1aa, G90D
YP_977354.1	catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate
YP_977358.1	activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization
YP_977364.1	Differs from Rv1212c by 2aa, I105V, W340L and from Mb1244c by 1aa, W340L
YP_977365.1	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate
YP_977366.1	In Mycobacterium bovis BCG and Mycobacterium tuberculosis strain H37Rv, PE14 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 5 bp deletion (cttgt-*) leads to a diffferent COOH terminus
YP_977367.1	Differs from Rv1215c by 1aa, S169A
YP_977369.1	Differs from Mb1249c by 1aa, A143T
YP_977370.1	Differs from Rv1218c by 1aa, R243Q
YP_977371.1	Differs from Rv1219c and Mb1251c by 1aa, C113W
YP_977373.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence
YP_977375.1	Differs from Rv1223 by 2aa, L288F, N445S
YP_977376.1	mediates the export of protein precursors bearing twin-arginine signal peptides
YP_977378.1	Differs from Rv1226c by 1aa, A450V
YP_977382.1	Differs from Rv1230c by 2aa, G45S, P97S
YP_977384.1	Differs from Rv1232c by 1aa, G149C
YP_977385.1	Differs from Rv1233c by 1aa, D46N
YP_977391.1	Differs from Rv1239c by 1aa, E139K, and from Mb1271c by 1aa, H195R
YP_977392.1	catalyzes the oxidation of malate to oxaloacetate
YP_977396.1	Differs from Rv1244 by 1aa, K242Q
YP_977400.1	kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth
YP_977401.1	Differs from Rv1249c by 1aa, T95A
YP_977402.1	Differs from Rv1250 by 1aa, G278R
YP_977405.1	Differs from Rv1253 by 1aa, V143M
YP_977407.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 3007 bp deletion (RD13) leads to the fusion of Rv1257c and Rv1255c, and the deletion of Rv1256c, compared to Mycobacterium tuberculosis strain H37Rv
YP_977410.1	In Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as a single gene. In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv1260 into 2 parts
YP_977411.1	In Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium Bovis, a frameshift due to a single base deletion (g-*) splits Rv1260 into 2 parts
YP_977413.1	Differs from Rv1262c by 1aa, R104P
YP_977414.1	catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia
YP_977415.1	Differs from Rv1264 by 1aa, C204R
YP_977417.1	In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, the pknH gene contains several substitutions, transitions and transversions compared to Mycobacterium tuberculosis strain H37Rv. The most significant difference results from a 127 bp to 24 bp substitution that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (596 aa versus 626 aa). Differs from Mb1297c by 2aa, F374L, I396N
YP_977421.1	Differs from Mb1301c by 1aa, A134T
YP_977425.1	Differs from Rv1274 by 1aa, P168L
YP_977427.1	Differs from Rv1276c by 1aa, S92T
YP_977436.1	with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP
YP_977437.1	in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis
YP_977439.1	In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a 153 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (405 aa versus 456 aa)
YP_977444.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_977446.1	catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine
YP_977447.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_977448.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate
YP_977449.1	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_977450.1	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_977451.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_977452.1	Differs from Mb1332 by 1aa, G121A, and from Rv1300 by 2aa, G121A, C194R
YP_977453.1	Differs from Rv1301 by 1aa, Q196P
YP_977454.1	Differs from Rv1302 by 1aa, G357V
YP_977456.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_977457.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0
YP_977458.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_977459.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_977460.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_977461.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_977462.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_977463.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_977464.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 2 bp deletion (cg-*) at the 3' end leads to a slightly shorter product compared to Mycobacterium tuberculosis strain H37Rv (144 aa versus 147 aa). Also differs from Rv1312 by 1aa, V3A
YP_977465.1	In Mycobacterium tuberculosis strain H37Rv, Rv1313c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG, a frameshift due to a 12 bp to 1 bp substitution (cttgtcgtggcc-t) splits Rv1313c into 2 parts
YP_977466.1	In Mycobacterium tuberculosis strain H37Rv, Rv1313c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG, a frameshift due to a 12 bp to 1 bp substitution (cttgtcgtggcc-t) splits Rv1313c into 2 parts
YP_977468.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_977470.1	In Mycobacterium bovis BCG Pasteur and Mycobacterium tuberculosis strain H37Rv, alkA exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a premature stop codon that splits alkA into 2 parts, alkAa and alkAb
YP_977473.1	Differs from Rv1320c by 1aa, A531T
YP_977474.1	Differs from Rv1321 by 1aa, R144S
YP_977477.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis
YP_977479.1	Differs from Rv1325c by 1aa, A320T
YP_977480.1	catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain
YP_977482.1	Differs from Rv1328 by 3aa, G532D, F576V, S801A
YP_977484.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate
YP_977485.1	involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA
YP_977492.1	converts L-glutamate to D-glutamate, a component of peptidoglycan
YP_977494.1	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_977495.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_977497.1	Differs from Rv1343c by 1aa, A81E
YP_977498.1	carries the fatty acid chain in fatty acid biosynthesis
YP_977499.1	converts medium- to long-chain aliphatic fatty acids into acyl adenylate; involved in mycobactin synthesis
YP_977504.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_977509.1	Differs from Rv1355c by 1aa (P81L)
YP_977511.1	Differs from Rv1357c and Mb1392c by 1aa, S276T
YP_977512.1	Differs from Rv1358 by 1aa A442D, and from Mb1393 by 1aa, G31V
YP_977513.1	Differs from Mb1394 by 1aa, G187R
YP_977515.1	Differs from Rv1361c by 3aa, Q30K, V55T, P325Q, and more extensively from Mb1396c due to several substitutions, transitions and transversions between codons 158-260
YP_977516.1	Differs from Rv1362c by 1aa, G103V
YP_977517.1	Difefrs from Mb1398c by 1aa, T155N
YP_977518.1	Differs from Rv1364c by 2aa, T236A, E465A
YP_977519.1	Differs from Rv1365c by 1aa, K82E
YP_977521.1	Differs from Rv1367c by 1aa, V169I
YP_977523.1	In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a frameshift due to a single base insertion (*-a) splits Rv1371 into 2 parts, with the latter being the more likely product
YP_977524.1	In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-a) splits Rv1371 into 2 parts, with the latter being the more likely product. Differs from both Mb1405 and Rv1371 by 1aa, V210I
YP_977525.1	Differs from Rv1372 and Mb1406 by 2aa, N75K, A101T
YP_977526.1	In Mycobacterium tuberculosis strain H37Rv, Rv1373 exists as a single gene as is the case in Mycobacterium bovis BCG Pasteur. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits Rv1373 into 2 parts, Mb1407 and Mb1408. Differs from Rv1373 by 2aa, additional P, P155, and L232P
YP_977527.1	Differs from Rv1374c by 1aa, A136T
YP_977528.1	Differs from Rv1375 by 1aa, R86G, and from Mb1410 by 1aa, R322P
YP_977529.1	Differs from Rv1376 by 1aa, P236R
YP_977531.1	Differs from Rv1378c by 1aa, W37R, and from Mb1413c by 1aa, R9H
YP_977532.1	regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity
YP_977533.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_977534.1	catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis
YP_977536.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_977537.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_977538.1	type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase
YP_977540.1	Differs from Rv1387 by 1aa, A94V
YP_977542.1	Essential for recycling GMP and indirectly, cGMP
YP_977543.1	Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_977544.1	catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine
YP_977545.1	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_977547.1	Differs from Rv1394c by 1aa, L135R
YP_977549.1	In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a 372 bp deletion leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (452 aa versus 576 aa).Differs from Rv1396c by 2aa, S66R, H300R
YP_977550.1	Differs from Rv1397c by 1aa, G103D
YP_977552.1	Differs from Rv1399c and Mb1434c by 1aa, A46P
YP_977555.1	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_977559.1	modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth
YP_977560.1	Differs from Rv1407 by 1aa, L427I
YP_977561.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_977562.1	Differs from Rv1409 by 2aa, N30K, T71A
YP_977565.1	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine
YP_977568.1	bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate
YP_977569.1	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not
YP_977573.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_977575.1	Differs from Mb1457 by 1aa, A86V
YP_977578.1	Differs from Rv1425 by 1aa, L343P
YP_977580.1	activates fatty acids by binding to coenzyme A
YP_977584.1	Differs from Rv1431 by 2aa, T65N, Q455K
YP_977586.1	Differs from Rv1433 and Mb1468 at C-terminal end due to 1bp deletion at position equivalent to H37Rv 1612222-1612222
YP_977588.1	In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, an in-frame insertion of 21 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (209 aa versus 202 aa). Differs from Rv1435c by 1aa, T67A
YP_977590.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_977591.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_977594.1	Differs from Rv1441c by 1aa G236D and from Mb1476c by 1aa T354N
YP_977599.1	Differs from Rv1446v by 1aa P192R
YP_977600.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_977601.1	catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate
YP_977602.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_977603.1	In Mycobacterium bovis, insertions of 27 bp, 207 bp and 27 bp, substitutions of 60 bp to 63 bp and 11 bp, and a 27 bp deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (1408 aa versus 1329 aa). In Mycobacterium bovis BCG Pasteur one 27bp-insertion is missing, leading to a product of 1399 aa
YP_977604.1	converts protoheme IX and farnesyl diphosphate to heme O
YP_977605.1	In Mycobacterium bovis BCG Pasteur, a insertion of 51 bp, several substitutions and a deletion of 207 bp, lead to a smaller product compared to its homolog Mycobacterium bovis (740 aa versus 795 aa)
YP_977606.1	Differs from Rv1453 by 1aa Q405P
YP_977612.1	Differs from Rv1459c by 1aa, E113K
YP_977613.1	Differs from Rv1460 by 2aa, F198I, V265 and from Mb1495 by 1aa, F198I
YP_977615.1	Differs from Rv1462 by 1aa, D183N
YP_977625.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_977627.1	Differs from Rv1473A by 1aa, P60S
YP_977629.1	Catalyzes the conversion of citrate to isocitrate
YP_977635.1	Differs from Rv1481 and Mb1517 by 1aa, D254N
YP_977638.1	Catalyzes a key regulatory step in fatty acid biosynthesis
YP_977639.1	protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic
YP_977640.1	First 270 aa identical to Mb1522c and Rv1486c (but differs by 1aa, N198K), then frameshifts due to extra base, g, at position equivalent to Mycobacterium tuberculosis strain H37Rv position 1676073-1676074
YP_977648.1	MDM; functions in conversion of succinate to propionate
YP_977649.1	Differs from Rv1494 and Mb1531 by 1aa, L12S
YP_977651.1	functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins
YP_977653.1	Differs from Rv1498c by 1aa, H191R
YP_977654.1	In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a single base transition (a-g) at the 5' start leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (63 aa versus 70 aa)
YP_977656.1	Differs from Rv1500 and Mb1538 by 1aa, E45D
YP_977658.1	In Mycobacterium bovis BCG Pasteur and Mycobacterium tuberculosis strain H37Rv, Rv1502 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv1502 into 2 parts, Mb1540 and Mb1541. Differs from Rv1502 by 1aa, C213Y
YP_977659.1	catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis
YP_977661.1	Differs from Rv1517 by 1aa, F188L
YP_977662.1	Differs from Rv1518 by 2aa, R266S, L317M
YP_977665.1	activates fatty acids by binding to coenzyme A
YP_977666.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transversion (c-a) creating a stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1107 aa versus 1146 aa). Differs from Rv1522c (1146 aa) by 1aa, P381S, and from Mb1549c, (1107 aa) by 2aa, T204A, S947N
YP_977671.1	Differs from Rv1527c by 2aa, T532P, L1439F
YP_977673.1	activates fatty acids by binding to coenzyme A
YP_977674.1	Differs from Rv1530 and Mb1557 by 1aa, L330P
YP_977680.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin)
YP_977681.1	involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
YP_977683.1	lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_977688.1	BCG_1596; In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, Rv1544 and Mb1571 exist as a single gene. In Mycobacterium bovis BCG Pasteur, two genes exist as a result of a 10 bp deletion that has occurred at a position equivalent to H37Rv position 1746147-1746156I
YP_977689.1	In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, Rv1544 and Mb1571 exist as a single gene. In Mycobacterium bovis BCG Pasteur, two genes exist as a result of a 10 bp deletion that has occurred at a position equivalent to H37Rv position 1746147-1746156I
YP_977692.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
YP_977693.1	Differs from Rv1548c by 1aa, G258D, and from Mb1575c by 1aa, V68A
YP_977694.1	In Mycobacterium tuberculosis strain H37Rv, Rv1549 and Rv1550 exist as 2 genes. In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, two single base insertions (*-c and *-c) lead to a single product. Differs from Rv1550 by 1aa, S362L
YP_977695.1	PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA
YP_977696.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_977697.1	In Mycobacterium tuberculosis strain H37Rv, Rv1553 and Rv1554 exist as 2 genes. In Mycobacterium bovis, a 4 bp insertion (*-gggg) leads to a single product and in Mycobacterium bovis BCG Pasteur a 10 bp insertion at position equivalent to H37Rv 1760171-1760172 leads to insertion of two additional Gly codons
YP_977698.1	in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane
YP_977700.1	In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a 2153 bp insertion leads to a new protein with no equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to the TbD1 region
YP_977701.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 2153 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Belongs to the TbD1 region
YP_977703.1	catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic
YP_977706.1	In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, treZa and treZb exist as a single gene, treZ. In Mycobacterium bovis BCG Pasteur, a single base deletion at position equivalent to H37Rv 1766233-1766233 leads to frameshift and two genes, treZa and treZb
YP_977707.1	In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, treZa and treZb exist as a single gene, treZ. In Mycobacterium bovis BCG Pasteur, a single base deletion at position equivalent to H37Rv 1766233-1766233 leads to frameshift and two genes, treZa and treZb
YP_977708.1	In Mycobacterium bovis BCG Pasteur, and in Mycobacterium tuberculosis strain H37Rv, treY exists as a single gene. In Mycobacterium bovis, a large deletion of 806 bp, RD17, splits Rv1563c into two parts, treYa and treYb
YP_977713.1	catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate
YP_977714.1	catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine
YP_977715.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_977717.1	In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis, Rv1587c possibly exists as a pseudogene that has been disrupted when the phage entered. In Mycobacterium bovis BCG Pasteur, the prophage is absent and the C-terminal part of protein differs accordingly
YP_977718.1	Differs from Rv1588c by 3aa, T63A, L91R, I131V
YP_977719.1	catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine
YP_977722.1	Differs from Rv1592c by 1aa, V322I
YP_977724.1	3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate
YP_977725.1	catalyzes the formation of oxaloacetate from L-aspartate
YP_977726.1	catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide
YP_977727.1	Differs from Rv1597 by 2aa, D21G, M93L, and from Mb1623 by 1aa, M93L
YP_977729.1	catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_977730.1	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis
YP_977731.1	catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis
YP_977732.1	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_977733.1	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis
YP_977734.1	Differs from Rv1604 by 3aa, H93Y, Q124P, L251P
YP_977735.1	catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_977736.1	PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers
YP_977739.1	with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine
YP_977741.1	involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water
YP_977742.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_977743.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_977744.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_977747.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_977748.1	Differs from Rv1618 by 1aa, L121H
YP_977754.1	Differs from Rv1624c by 1aa, A178T
YP_977758.1	Differs from Rv1628c and Mb1654c by 1aa, V93A
YP_977759.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_977760.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_977761.1	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain
YP_977763.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_977764.1	Differs from Rv1634 by 2aa, Q13E, R198G, and from Mb1660 by 1aa, Q13E
YP_977768.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_977771.1	catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_977772.1	IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits
YP_977774.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_977775.1	Differs from Rv1644 by 1aa, P232L
YP_977778.1	Differs from Rv1647 by 1aa, P2A
YP_977780.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_977781.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_977782.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, an in-frame insertion of 21 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1018 aa versus 1011 aa). Differs from Rv1651c by insertion of 7aa at position 152 and by 1aa, V179A
YP_977783.1	catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate
YP_977784.1	bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate
YP_977785.1	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate
YP_977786.1	catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine
YP_977787.1	catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation
YP_977788.1	regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes
YP_977789.1	catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming
YP_977790.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_977792.1	Differs from Rv1661 by 2aa, W670R, P1176S
YP_977793.1	Differs from Rv1662 by 6aa, Y78D, deletion of V692, V807A, G1260R, T1356A, C1468Y, and from Mb1690 by 1aa, deletion of V692
YP_977795.1	Differs from Rv1664 by 2aa, T36A, P350A
YP_977798.1	In Mycobacterium tuberculosis strain H37Rv, Rv1668c and Rv1667c exist as 2 genes with a small overlap between them. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 10 bp insertion (*-tcttgccgcg) leads to a single product
YP_977805.1	Differs from Rv1675c by 1aa, A59V
YP_977810.1	Differs from Mb1707 by 1aa, A230G
YP_977813.1	activates fatty acids by binding to coenzyme A
YP_977816.1	Differs from Rv1686c by 1aa, F20V
YP_977818.1	responsible for recognizing base lesions in the genome and initiating base excision DNA repair
YP_977819.1	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr)
YP_977820.1	In Mycobacterium bovis, a 2 bp insertion (*-ac) at the 5' end, leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG Pasteur(139 aa versus 127 aa)
YP_977825.1	catalyzes the phosphorylation of NAD to NADP
YP_977829.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_977830.1	Differs from Mb1726 by 2aa, F43L, A202T
YP_977831.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_977833.1	Differs from Rv1703c and Mb1729c by 1aa, S48G
YP_977834.1	Differs from Rv1704c by 2aa, L93R, S122G, and from Mb1730c by 1aa, S122G
YP_977835.1	Differs from Rv1705c by 2aa, A2D, V313L, and from Mb1731c by 1aa, A2D
YP_977838.1	Differs from Rv1707 by 1aa, Q438R
YP_977839.1	Differs from Rv1708 by 1a,a T56A
YP_977843.1	Catalyzes the formation of (d)CDP from ATP and (d)CMP
YP_977844.1	synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_977846.1	In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur, Rv1715/fadB3 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) splits fadB3 into 2 parts, fadB3a and fadB3b
YP_977847.1	Differs from Rv1716 by 2aa, G178S, A276V
YP_977849.1	In Mycobacterium tuberculosis strain H37Rv, exists as a single gene. In Mycobacterium bovis AF2122/97 and Mycobacterium bovis BCG Pasteur, a single base deletion (c-*) leads to a shorter product with a different COOH terminus
YP_977853.1	an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_977857.1	Differs from Rv1726 by 1aa, Y326H, and from Mb1755 by 1aa, A61P
YP_977858.1	Differs from Rv1727 and Mb1756 by 1aa, D22E
YP_977862.1	NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate
YP_977864.1	Differs from Rv1733c by 1aa, H68Q
YP_977865.1	Differs from Mb1763c by 1aa, T79A
YP_977867.1	Diffesr from Rv1736c by 2aa, H53D, G77D
YP_977870.1	Differs from Rv1739c by 1aa, L134R
YP_977872.1	Differs from Rv1741 by 1aa, T67K
YP_977873.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-c) leads to shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_977874.1	Differs from Mb1772 by 1aa, V56D
YP_977875.1	Differs from Rv1744c by 1aa, Q121R
YP_977876.1	catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate
YP_977877.1	Differs from Rv1746 by 1aa, T325A
YP_977881.1	activates fatty acids by binding to coenzyme A
YP_977882.1	Differs from Rv1751 by 2aa, T311M, L439V, and from Mb1780 by 1aa, T311M
YP_977884.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, PPE24 differs in the 26 aa tandem repeat region, two copies less (in-frame deletion of 156 bp), and in the 25 aa repeat region, 2 and one more copies (in-frame insertion of 150bp and 75bp), respectively, compared to their homolog in Mycobacterium tuberculosis strain H37Rv
YP_977885.1	Differs from Rv1754c and Mb1783c by 1aa, S546N
YP_977886.1	Truncated by RvD2 deletion (6804bp) in Mycobacterium tuberculosis strain H37Rv
YP_977887.1	No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to the RvD2 region
YP_977888.1	No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to RvD2 region
YP_977889.1	No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to RvD2 region
YP_977890.1	Belongs to the RvD2 region. In Mycobacterium tuberculosis strain H37Rv, Rv1758 is interrupted by IS6110 insertion element and the 5'-end is deleted
YP_977891.1	In Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (c-*) splits wag22 into 2 parts, wag22a and wag22b. Differs from Mb1789c and Rv1759c by three deletions R129 replaced by AG, 5aa deletion at position 739 and 12aa deletion at position 777 making protein smaller (802 versus 820)
YP_977892.1	In Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (c-*) splits wag22 into 2 parts, wag22a and wag22b
YP_977893.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; Also differs from Rv1760 by 1aa, V219E
YP_977896.1	In Mycobacterium tuberculosis strain H37Rv this region is occupied by IS6110 which interrupts the gene and appears to have deleted sequences downstream. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, there is an 848bp sequence that has replaced a 121bp sequence corresponding to H37Rv positions 1997332-1997452
YP_977897.1	In Mycobacterium tuberculosis strain H37Rv this region is occupied by IS6110 which appears to have deleted sequences downstream. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, there is an 848bp sequence that has replaced a 121bp sequence corresponding to H37Rv positions 1997332-1997452
YP_977898.1	In Mycobacterium bovis BCG Pasteur, deletion of 9068 bp (region of difference RD14), compared to Mycobacterium tuberculosis H37Rv2 (position: 1998226..2007293) and Mycobacterium bovis AF2122/97 (position 1988666..1997751), removes genes Rv1765A-Rv1772 and merges truncated genes Rv1773c and Rv1765c
YP_977902.1	Differs from Rv1777 by 1aa Q325H
YP_977903.1	Differs from Rv1778c by 1aa T32R
YP_977906.1	Differs from Rv1781c and Mb1810c by 1aa, T12A
YP_977907.1	Differs from Rv1782 by 1aa H41R
YP_977908.1	In Mycobacterium tuberculosis strain H37Rv, Rv1783 and Rv1784 exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base transversion (a-t) leads to a single product. Differs from Rv1783 and Mb1812 by 1aa, V692A, identical to Rv1784
YP_977911.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 8 bp to 5 bp substitution (agcccggt-ccggg), leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (364 aa versus 365 aa). Identical to Mb1815
YP_977913.1	Differs from Mb1817 by 1aa, S274A, identical to Rv1789
YP_977914.1	Identical to Rv1790 differs from Mb1818 by 1aa, P190S
YP_977916.1	Differs from Rv1792 by 1aa Q48M
YP_977919.1	Differs from Mb1823 and Rv1795 by 1aa, T256A and D261G, respectively
YP_977924.1	Differs from Rv1800 by 3aa, W144C, V253F, V432I, and from Mb1828 by 1aa,V432I
YP_977927.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS32 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base transition (c-t) splits PE_PGRS32 into 2 parts, PE_PGRS32a and PE_PGRS32b
YP_977928.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS32 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base transition (c-t) splits PE_PGRS32 into 2 parts, PE_PGRS32a and PE_PGRS32b
YP_977932.1	Differs from Rv1807 by 2aa, S223F, L234V. Identical to Mb1836
YP_977933.1	Differs from Rv1808 by 1aa, A301G
YP_977934.1	In Mycobacterium tuberculosis strain H37Rv, PPE33 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base transition (c-t) splits PPE33 into 2 parts, PPE33a and PPE33b
YP_977937.1	Differs from Rv1812c by 1aa, P30L
YP_977940.1	Differs from Rv1815 by 1aa, F83I
YP_977944.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 9 bp insertion (*-gccgccggc), leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (501 aa versus 498 aa). Differs from Rv1818c by 4aa, S233G, and deletion of 3aa near C-terminus. Identical to Mb1849c
YP_977945.1	Differs from Rv1819c by 1aa, V603I
YP_977947.1	SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins
YP_977952.1	part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor
YP_977955.1	Differs from Rv1829 by 1aa R93C
YP_977958.1	acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine
YP_977960.1	Differs from Mb1865 by 1aa, V272A
YP_977962.1	Differs from Rv1836c by 2aa, C137R, H591R
YP_977963.1	catalyzes the formation of malate from glyoxylate and acetyl-CoA
YP_977966.1	In Mycobacterium bovis, an in-frame deletion of 147 bp leads to a shorter protein compared to its homolog in Mycobacterium tuberculosis strain H37Rv (466 aa versus 518 aa). In Mycobacterium bovis BCG Pasteur a deletion of 1bp, splits PPE34 into 2 parts, PPE34a and PPE34b
YP_977967.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 12 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (349 aa versus 345 aa)
YP_977968.1	Differs from Rv1842c by 1aa, S437L
YP_977969.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_977970.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_977971.1	Differs from Rv1845c and Mb1876c by 1aa, A222V
YP_977972.1	Differs from Rv1846c by 1aa, Y92D
YP_977973.1	Differs from Rv1847 by 1aa, L90V
YP_977974.1	UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter
YP_977975.1	ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta)
YP_977976.1	ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits
YP_977977.1	Differs from Rv1851 by 1aa, L34V
YP_977980.1	Differs from Rv1854c by 1aa, R313G, and Mb1885c by 2aa, R284W, R313G
YP_977982.1	Differs from Rv1856c by 1aa, H185R
YP_977985.1	Differs from Rv1859 by 1aa, M313T
YP_977986.1	Differs from Rv1860 by 1aa, L136F
YP_977992.1	Differs from Rv1866 by 1aa, Q17E
YP_977993.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_977994.1	Differs from Rv1868 and Mb1899 by 1aa, G621D
YP_977995.1	Differs from Mb1900c and Rv1869c by 1aa, P4S
YP_977996.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base transversion (t-a) and a single base transition (c-t) lead to a slightly longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (222 aa versus 211 aa)
YP_977998.1	Differs from Rv1872c by 2aa, A59G, A176V
YP_977999.1	Differs from Mb1904 by 1aa, D102N
YP_978003.1	In Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-c), splits Rv1877 into 2 parts
YP_978004.1	In Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-c), splits Rv1877 into 2 parts
YP_978005.1	Identical to Rv1878, differs from Mb1910 by 1aa, A275T
YP_978010.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 15 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (158 aa versus 153 aa)
YP_978012.1	catalyzes the interconversion of chorismate to prephenate
YP_978013.1	Differs from Rv1886c and Mb1918c by 1aa, L140F
YP_978014.1	Differs from Rv1887 and Mb1919 by 1aa, C121Y
YP_978015.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 10 bp insertion (*-tccgatcacc) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv (239 aa versus 186 aa)
YP_978023.1	In Mycobacterium tuberculosis strain H37Rv, Rv1895 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, two frameshifts due to a single base deletion (a-*) and a single base insertion (*-t), consecutively, splits Rv1895 into 2 main parts
YP_978024.1	In Mycobacterium tuberculosis strain H37Rv, Rv1895 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, two frameshifts due to a single base deletion (a-*) and a single base insertion (*-t), consecutively, splits Rv1895 into 2 main parts, Mb1928 and Mb1929
YP_978026.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_978028.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (358 aa versus 343 aa)
YP_978029.1	Differs from Rv1900c and Mb1935c by 1aa, M204I and R170Q, respectively
YP_978033.1	Differs from Rv1904 by 1aa, M130T
YP_978034.1	Differs from Rv1905c by 1aa, T240P
YP_978037.1	Differs from Rv1908c by 1aa, L463R
YP_978038.1	Differs from Rv1909c and Mb1944c by 1aa, V46A
YP_978041.1	Differs from Rv1912c by 1aa, G328D
YP_978042.1	Differs from Rv1913 and Mb1948 by 1aa, C7R
YP_978044.1	In Mycobacterium tuberculosis strain H37Rv, aceAa and aceAb exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base insertion (*-t) leads to a single product
YP_978045.1	Equivalent to Mb1951c and Rv1917c but differs by several in-frame insertion and deletion events. Differs from Mb1951c by 69 bp insertion, 69 bp deletion and 225 bp deletion. Differs from Rv1917c by deletions of 12 and 138 bp, insertions of 552 and 150 bp, and substitution of 52 bp by 628 bp
YP_978046.1	In Mycobacterium tuberculosis strain H37Rv, PPE35 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-t) splits PPE35 into 2 parts, PPE35a and PPE35b. Differs from Mb1953c by 1aa, F565V
YP_978048.1	Differs from Rv1920 by 1aa, I130M
YP_978051.1	Differs from Rv1923 by 2aa, D73G, N181D
YP_978053.1	activates fatty acids by binding to coenzyme A
YP_978060.1	antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein
YP_978063.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_978067.1	In Mycobacterium bovis, a single base deletion (t-*) leads to a longer product with a different COOH part compared to its homologs in Mycobacterium tuberculosis H37Rv and Mycobacterium bovis BCG Pasteur (244 aa versus 171 aa)
YP_978072.1	Differs from Rv1944c and Mb1979c by 2aa, E4D, A5T, due to 2 bp substitution ta-cc
YP_978073.1	Differs from Mb1980 and Rv1945 by substitutions of 44, 29, 2, 10 and 34 bp, or 44, 29, 4, 2, 10 and 34 bp, respectively. Corresponding to 10 aa from Rv1945, L242V, N264H, A267G, F268L, A271G, K285R, I291V, N328H, H417K and P426A, and to 9 aa from MB1980, N264H, A267G, F268L, A271G, K285R, I291V, N328H, H417K and P426A
YP_978074.1	Differs from Rv1946c by 1aa, T98A
YP_978076.1	Differs from Rv1948c by 1aa, R5G
YP_978077.1	Differs from Rv1949c by 1aa, L188F
YP_978082.1	Differs from Rv1954c by 1aa, R150H
YP_978093.1	In Mycobacterium bovis an in Mycobacterium bovis BCG Pasteur, a large deletion of 12719 bp (RD7) leads to the loss of the COOH part of Rv1964|yrbE3A, the entire mce3 operon and the following genes up to Rv1978, compared to Mycobacterium tuberculosis strain H37Rv. Follow by a second deletion of 10287bp, RD2 region (only in Mycobacterium bovis BCG Pasteur), which removes genes Rv1979c-Rv1787 and merges truncated part of Rv1978 and Rv1988 compared to Mycobacterium tuberculosis strain H37Rv
YP_978094.1	In Mycobacterium bovis BCG Pasteur, a large deletion of 10787 bp, RD2, removes genes Rv1979c-Rv1987 and merges truncated part of Rv1978 and Rv1988 compared to Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis AF2122/97
YP_978104.1	Differs from Rv1997 and Mb2020 by 1aa, D138E
YP_978105.1	Differs from Rv1998c by 1aa, R230S
YP_978108.1	Differs from Rv2001 by 1aa, H113R
YP_978113.1	Differs from Rv2006 and Mb2029 by 1aa, S80G and L1245P, respectively
YP_978116.1	Differs from Rv2009 by 1aa, D63N
YP_978120.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base transition (c-t) at the 5' start, leads to a longer product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (206 aa versus 159 aa)
YP_978121.1	Identical to Mb2037 including extra 5 aa at C-terminus compared to Rv2014
YP_978122.1	Differs from Mb2038c by 1aa S59L
YP_978124.1	Differs from Rv2017 by 1aa, E262A
YP_978125.1	Differs from Rv2018 by 1aa, G116D
YP_978131.1	Belongs to the RvD1 region. Absent in Mycobacterium tuberculosis strain H37Rv
YP_978132.1	Belongs to the RvD1 region. Absent in Mycobacterium tuberculosis strain H37Rv; Differs from Mb2048c by 1aa, E139K
YP_978133.1	In Mycobacterium tuberculosis strain H37Rv, a large deletion region (RvD1) exists in between Rv2023 and Rv2024. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 5000 bp insertion at this region results in Mb2049c being a much larger product with a different COOH part (1606 aa versus 515 aa), and in 2 extra genes, Mb2046c and Mb2047c; Differs from N-terminal part of Rv2024c (truncated by RvD1) by 3aa, R47W, G154D, C289R and Mb2049c by 1aa, F341V
YP_978136.1	Differs from Rv2027c by 1aa, V15L
YP_978139.1	In Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG Pasteur, Rv2030c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv2030c into 2 parts, Mb2055c and Mb2056c
YP_978141.1	Differs from Rv2032 by 1aa, L318P
YP_978145.1	Differs from Rv2036 by 1aa, V93A due to 2bp substitution cc-tt
YP_978146.1	Differs from Rv2037c by 1aa, Y312C
YP_978148.1	Differs from Rv2039c by 1aa, F131V
YP_978150.1	Differs from Mb2067c by 1aa, A122V
YP_978152.1	Differs from Rv2043c by 1aa, D57H
YP_978155.1	Differs from Rv2046 by 1aa, P17S
YP_978157.1	Differs from Mb2074c and Rv2048c in several positions due to various substitutions, transitions and transversions
YP_978162.1	F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein
YP_978164.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_978165.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif
YP_978166.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif
YP_978167.1	required for 70S ribosome assembly
YP_978171.1	with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism
YP_978174.1	catalyzes the interconversion of precorrin-8X and hydrogenobyrinate
YP_978178.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription
YP_978179.1	CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6
YP_978180.1	Differs from Rv2071c by 1aa, M145I
YP_978181.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a large 2029 bp deletion (H37Rv2.2330073-2332101-*)(RD9) leads to the loss of the NH2 part of cobL, the entire Rv2073 and Rv2074, and the COOH part of Mb2100c. In addition, while cobL exists as a single gene in Mycobacterium tuberculosis strain H37Rv, in Mycobacterium bovis a frameshift due to a single base insertion (*-t) splits cobL into 2 parts, cobLa and cobLb
YP_978182.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a large deletion of 2029 bp (H37Rv2.2330073-2332101-*) (RD9) leads to the loss of the NH2 part of cobL, the entire Rv2073 and Rv2074, and the COOH part of Rv2075c. In addition, while cobL exists as a single gene in Mycobacterium tuberculosis strain H37Rv, in Mycobacterium bovis a frameshift due to a single base insertion (*-t) splits cobL into 2 parts, cobLa and cobLb
YP_978183.1	In Mycobacterium bovis AF2122/97 and in Mycobacterium bovis BCG Pasteur, a large 2029 bp deletion (RD9) leads to the loss of the COOH part of Mb2100c, the entire Rv2074 and Rv2073, and the NH2 part of cobL compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_978187.1	Differs from Rv2078 by 1aa, G6E
YP_978188.1	Differs from Rv2079 by 2aa, C47Y, L216P
YP_978189.1	Differs from Rv2080 by 1aa, A23V
YP_978190.1	In Mycobacterium bovis, a 3 bp in-frame insertion (*-ggg) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (147 aa versus 146 aa). In Mycobacterium bovis BCG Pasteur, insertion of 11bp or 8bp compared to its homologs in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis leads to a product with a different C-terminal part
YP_978191.1	Differs from Mb2108 (721 aa) and from Rv2082 (721 aa) by 26 codon in-frame deletion and from Rv2082 by 2aa, A183T, R612L
YP_978192.1	Differs from Rv2083 by 1aa, V256L
YP_978193.1	In Mycobacterium tuberculosis strain H37Rv, Rv2084 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to an 11 bp insertion (*-ggcgtacacac), splits Rv2084 into 2 parts
YP_978199.1	In Mycobacterium bovis BCG Pasteur, a 114 bp in-frame deletion leads to a shorter product compared to its ortholog in Mycobacterium tuberculosis strain H37Rv (355 aa versus 393 aa) and a 57 bp in-frame deletion leads to a shorter product compared to its ortholog in Mycobacterium bovis (355 aa versus 374 aa). Difference is due to copy number of tandem motif: DPTSGDPLHPAPPRLRSPL (or variant thereof) near N-terminus. Also differs from Rv2090 by 1aa, L320F
YP_978201.1	Differs from Rv2092c by 1aa, M178T
YP_978203.1	TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_978204.1	Differs from Mb2122c by 1aa, A267V
YP_978207.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS36 and PE21 exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur,a single base insertion (*-c) leads to a single product more similar to PE_PGRS36. There is also a 3 bp in-frame deletion (ggc-*)
YP_978209.1	Differs from Rv2101 by 3aa, L462M, Q601P, S652A
YP_978215.1	Differs from Rv2109c by 2aa, P135R, G182R
YP_978218.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 57 bp in-frame deletion at the NH2 part, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (535 aa versus 554 aa)
YP_978219.1	Differs from Mb2137 by 1aa, S278L, and from Rv2113 by 1aa, P207T
YP_978227.1	long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors
YP_978228.1	catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis
YP_978229.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 27 bp in-frame deletion leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 473 aa)
YP_978230.1	Differs from Rv2124c by 1aa, V752I
YP_978231.1	Differs from Rv2125 by 1aa, S33G
YP_978233.1	Differs from Rv2127 by 2aa, D9G, S44G
YP_978236.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_978242.1	BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters UDP disphosphate which reduces the pool of lipid carrier available to the cell
YP_978244.1	Differs from Mb2162 by 3aa, VQV348-350SRF, due to 7bp substitution in latter, tccaggt-gtccagg
YP_978245.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_978256.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_978258.1	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_978259.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_978261.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_978262.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_978264.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_978266.1	In Mycobacterium tuberculosis strain H37Rv, Rv2160A and Rv2160c exist as 2 genes with an overlap region between them. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a 4 bp insertion (*-ggaa) leads to a single product
YP_978268.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, in-frame deletions of 108 bp and 18 bp leads to a shorter product than in Mycobacterium tuberculosis strain H37Rv (490 aa versus 532 aa)
YP_978270.1	Differs from Mb2188c by 1aa, V202A
YP_978272.1	MraZ; UPF0040; crystal structure shows similarity to AbrB
YP_978278.1	Differs from Rv2174 and Mb2196 at 3'-end owing to frameshift due to 1 bp insertion (t) at position corresponding to H37Rv coordinates 2437401-2437402, and from Rv2174 by 1aa, S451A.
YP_978279.1	Differs from Rv2175c by 1aa, L17P
YP_978280.1	Differs from Rv2176 by 1aa, A52S
YP_978281.1	Differs from Rv2177c by 1aa, K115T
YP_978282.1	Differs from Rv2178c by 1aa, E265D
YP_978284.1	Differs from Rv2180c by 1aa, T156P
YP_978291.1	In Mycobacterium tuberculosis strain H37Rv, fadD15 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to single base deletion (t-*) splits fadD15 into 2 parts
YP_978292.1	In Mycobacterium tuberculosis strain H37Rv, fadD15 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to single base deletion (t-*) splits fadD15 into 2 parts. Differs from Rv2187 by 2aa, I8T, E287G
YP_978296.1	contains 3'-5'exonuclease domain
YP_978297.1	Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_978300.1	Differs from Rv2195 by 1aa, I281M
YP_978302.1	Differs from Rv2197c by 1aa, S202A
YP_978312.1	catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole
YP_978313.1	catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole
YP_978315.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_978316.1	catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein
YP_978318.1	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides
YP_978320.1	Differs from Rv2215 and Mb2238 by 1aa, V517L
YP_978322.1	lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein
YP_978323.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_978324.1	Differs from Rv2219 by 1aa, L74F
YP_978327.1	catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme
YP_978329.1	Differs from Rv2223c and Mb2247c by 1aa, S307A
YP_978331.1	catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate
YP_978332.1	Differs from Rv2226 and Mb2250 by 1aa, N299D and G31D, respectively
YP_978333.1	In Mycobacterium tuberculosis strain H37Rv, Rv2227 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 1 bp to 2 bp substitution (t-cc) splits Rv2227 in two parts
YP_978334.1	In Mycobacterium tuberculosis strain H37Rv, Rv2227 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 1 bp to 2 bp substitution (t-cc) splits Rv2227 in two parts
YP_978336.1	Differs from Rv2229c by 1aa, Q239R
YP_978342.1	CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
YP_978346.1	Differs from Rv2240c by 1aa, K259T
YP_978347.1	E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC
YP_978348.1	Differs from Rv2242 and Mb2266 by 1aa, T363A
YP_978350.1	carries the fatty acid chain in fatty acid biosynthesis
YP_978351.1	FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_978352.1	FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_978354.1	In Mycobacterium bovis and Mycobacterium tuberculosis, Rv2248 and Mb2272 exist as single gene. In Mycobacterium bovis BCG Pasteur, the ortholog is split into two parts owing to single base insertion in G-string (-g) at position equivalent to Mycobacterium tuberculosis position 2522481-2522482
YP_978355.1	In Mycobacterium bovis and Mycobacterium tuberculosis, Rv2248 and Mb2272 exist as single gene. In Mycobacterium bovis BCG Pasteur, the ortholog is split into two parts owing to single base insertion in G-string (-g) at position equivalent to Mycobacterium tuberculosis position 2522481-2522482
YP_978357.1	Differs from Mb2274c by 1aa, D68A
YP_978358.1	In Mycobacterium tuberculosis H37Rv, Rv2250A and Rv2251 exist as 2 genes with an overlap region between them. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base deletion (g-*) leads to a single product
YP_978359.1	involved in the biosynthesis of phosphatidylinositol mannosides (PIMs); the enzyme from Mycobacterium tuberculosis can phosphorylate a variety of amphipathic lipids
YP_978361.1	Differs from Rv2254c by 1aa, V68A
YP_978363.1	Differs from Rv2256c by 1aa, G26A
YP_978368.1	In Mycobacterium tuberculosis strain H37Rv, Rv2262c and Rv2261c exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 2 bp deletion (ct-*) results in a single product
YP_978374.1	Differs from Rv2268c and Mb2291c by 1aa, F203L
YP_978376.1	Differs from Mb2293 by 1aa, P152L
YP_978380.1	Differs from Rv2274c by 1aa, M33I
YP_978381.1	Differs from Rv2275 and Mb2298 by 1aa, A261E
YP_978383.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 1358 bp deletion containing an IS6110 sequence, disrupts the 5' start of Rv2277c resulting in a slightly shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (299 aa versus 301 aa). Differs from Mb2300c by 1aa
YP_978390.1	In Mycobacterium tuberculosis strain H37Rv, Rv2286c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, an in-frame stop codon due to a single base transition (c-t) splits Rv2286c into 2 parts
YP_978391.1	In Mycobacterium tuberculosis strain H37Rv, Rv2286c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base transition (c-t) splits Rv2286c into 2 parts
YP_978395.1	In Mycobacterium tuberculosis strain H37Rv, Rv2290 exists as a single gene. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (c-*), splits lppO into 2 parts, lppOa and lppOb
YP_978396.1	In Mycobacterium tuberculosis strain H37Rv, Rv2290 exists as a single gene. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (c-*), splits lppO into 2 parts, lppOa and lppOb
YP_978397.1	In Mycobacterium bovis, truncation at the 5' start due to a 2 bp deletion (tg-*), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG Pasteur (256 aa versus 284 aa). Differs from Rv2291 by 1aa, A262E
YP_978398.1	In Mycobacterium tuberculosis strain H37Rv, Rv2293c and Rv2292c exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base insertion (*-g) results in a single product
YP_978404.1	molecular chaperone
YP_978410.1	Differs from Rv2305 by 1aa, D148G
YP_978411.1	Differs from Rv2306A by 1aa, V47I
YP_978413.1	Differs from Mb2330c by 2aa, T25M, W235R
YP_978417.1	Differs from Rv2308 by 1aa, V43G
YP_978419.1	Differs from Rv2309A by 1aa, K53E
YP_978426.1	Differs from Rv2316 by 1aa, L126V
YP_978428.1	Differs from Rv2318 by 1aa, V354L
YP_978429.1	Differs from Rv2319c and Mb2346c by 1aa, G105E
YP_978433.1	Differs from Rv2323c by 1aa, T113A
YP_978440.1	Differs from Rv2330c and Mb2357c by 1aa, A97S
YP_978442.1	Differs from Rv2331A by 1aa, L46I
YP_978443.1	malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate
YP_978444.1	In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, single base insertion (*-g) leads to a slightly longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (523 aa versus 537 aa). Also differs from Rv2333c by 2aa, Y69D, Q503H
YP_978448.1	Differs from Rv2337c by 1aa, V119G
YP_978450.1	In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base transition (g-a) splits mmpL9 into 2 parts, mmpL9a and mmpL9b
YP_978451.1	In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) splits mmpL9 into 2 parts, mmpL9a and mmpL9b
YP_978452.1	Differs from Rv2340c and Mb2369c by 1aa, T222D
YP_978455.1	synthesizes RNA primers at the replication forks
YP_978456.1	dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate
YP_978458.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a large 8963 bp deletion (RD5) leads to the loss of the NH2 part of Rv2346c, and the 9 following CDSs up to Rv2356 including the 3 phospolipases C enzymes plcC, plcB and plcA, compared to the homolog in Mycobacterium tuberculosis H37Rv
YP_978459.1	Compared to Mycobacterium bovis, there has been a 2579bp bp deletion at position equivalent to M. bovis 2604493-2607071, this has resulted in an in-frame fusion of the 5'-end of PPE40 with the 3'-end of PPE71 probably due to a homologous recombination event between codons 68 and 174 of PPE40 as the PPE40 and PPE71 genes have identical 5'-ends (first 535 bp). Differs from Mb2376c (PPE71) by extra 11aa, insertion of A at position 68 due to 3bp insertion (present in PPE40) and STNVGSGNIG at position 307 due to 30 bp insertion. M. bovis BCG Pasteur thus has three copies of tandem repeat STNVGSGNIG compared to two in Mb2376c. The 3'-end of PPE71 of M. bovis BCG Pasteur has also been truncated as a result of the same deletion described in In Mycobacterium bovis, 8963 bp deletion (RD5)
YP_978460.1	Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_978462.1	Differs from Rv2359 by 1aa, R64H
YP_978463.1	Differs from Rv2360c by 1aa, T66A
YP_978464.1	catalyzes the formation of UDP pyrophosphate from isopentenyl pyrophosphate
YP_978465.1	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_978466.1	catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia
YP_978467.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_978475.1	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_978476.1	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_978477.1	Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
YP_978480.1	Differs from Rv2377c by 1aa, A69V
YP_978482.1	Differs from Rv2379c by 1aa, D589E
YP_978486.1	Differs from Rv2383c by 2aa, Q264R, P1253T, and from Mb2404c by 1aa, P1253T
YP_978489.1	catalyzes conversion of chorismate to salicylate, in mycobactin siderophore construction; requires Mg(2+) for function
YP_978491.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_978493.1	Differs from Mb2411c by 1aa, I33T
YP_978495.1	catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite
YP_978496.1	In Mycobacterium bovis BCG Pasteur, duplication of 54 bp segment after codon 3 leads to additional 18 aa and two tandem copies of motif PATMQSAAMLRSGAIEAP, compared to its ortholog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis AF2122/97
YP_978497.1	Differs from Rv2394 by 1aa Q396R
YP_978498.1	In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis BCG Pasteur, as in Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits Rv2395 into 2 parts. The frameshift occurs after the 44th codon
YP_978499.1	In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits Rv2395 into 2 parts. BCG_2410 also differs from Rv2395 by 1aa, P396S
YP_978500.1	Identical to Mb2418 of Mycobacterium bovis, including 3 bp deletion (gcc-*) that leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (360 aa versus 361 aa) due to deletion of A95. Also differs from Rv2396 by 2aa, N26S, S324N
YP_978502.1	Differs from Rv2398c by 1aa, A141G, and from Mb2420c by 1aa, R264H
YP_978508.1	Differs from Rv2403c by 1aa, L127V
YP_978509.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_978512.1	member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions
YP_978517.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_978519.1	In Mycobacterium bovis, a single base insertion (*-t) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv and in Mycobacterium bovis BCG Pasteur (523 aa versus 514 aa)
YP_978520.1	Differs from Rv2415c by 1aa, L291R
YP_978521.1	Differs from Mb2439c by 1aa, T76A
YP_978524.1	Differs from Mb2442c by 1aa, A165V
YP_978525.1	Differs from Rv2420c and Mb2443c by insertion of 1aa, Pro, at position 126 due to 3bp insertion (gcg) at position equivalent to Mycobacterium bovis 2685985-2685986
YP_978526.1	transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria
YP_978529.1	In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 2 bp deletion (gt-*) splits Rv2424c into 2 parts. Differs from Rv2424c by 3aa, I172T, A173T and Y192H
YP_978530.1	In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 2 bp deletion (gt-*) splits Rv2424c into 2 parts
YP_978532.1	Differs from Rv2426c by 1aa, L113F
YP_978533.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_978542.1	Differs from Rv2436 by 2aa, V274A, A282V
YP_978544.1	catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers
YP_978546.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_978547.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_978548.1	involved in the peptidyltransferase reaction during translation
YP_978552.1	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate
YP_978555.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_978556.1	Differs from Rv2449c and Mb2476c by 1aa, C273R
YP_978557.1	Differs from Rv2450c by 1aa, Q126R
YP_978558.1	Differs from Rv2451 by 1aa, D63N
YP_978560.1	MobA; links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide; involved in molybdenum cofactor biosynthesis
YP_978561.1	catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin
YP_978564.1	binds and unfolds substrates as part of the ClpXP protease
YP_978565.1	converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines
YP_978566.1	Differs from Mb2486 by 1aa, M55I
YP_978567.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_978568.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_978569.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_978572.1	catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity
YP_978574.1	Differs from Rv2467 and Mb2494 by 1aa, M18I
YP_978576.1	Differs from Rv2469c by 2aa, G28S, S99A
YP_978578.1	Differs from Rv2471 by 1aa, S206W
YP_978581.1	Differs from Mb2501c by 1aa, A30V
YP_978583.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 3 bp deletion (cgg-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1623 aa versus 1624 aa). Differs from Rv2476c by 2aa, loss of A501 due to 3 bp deletion and G1042S
YP_978584.1	ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence
YP_978587.1	PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA
YP_978588.1	Differs from Rv2483c by 1aa, G189C
YP_978589.1	Differs from Rv2484c by 1aa, D466G
YP_978591.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_978592.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts, the first due to a single base insertion (*-c) and the second due to a single base deletion (g-*) splits PE_PGRS42 into 3 parts, PE_PGRS42a and PE_PGRS42b and PE_PGRS42d while in Mycobacterium bovis BCG Pasteur, PE_PGRS42a and PE_GRRS42b are fused
YP_978593.1	Differs from Rv2488c and Mb2515c by 1aa E535D
YP_978595.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS43 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 8 bp insertion (*-gggggggg ) splits PE_PGRS43 into 2 parts, PE_PGRS43a and PE_PGRS43b while in Mycobacterium bovis BCG Pasteur, a 1 bp insertion (equivalent to Mycobacterium tuberculosis H37Rv position 2804942-2804943) causes a different frameshift but at same place
YP_978596.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS43 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 8 bp insertion (*-gggggggg ) splits PE_PGRS43 into 2 parts, PE_PGRS43a and PE_PGRS43b while in Mycobacterium bovis BCG Pasteur, a 1 bp insertion (equivalent to Mycobacterium tuberculosis H37Rv position 2804942-2804943) causes a different frameshift but at same place
YP_978598.1	Differs from Rv2492 by 1aa, D70A
YP_978601.1	Differs from Rv2495c by 2aa, A107T, W208R
YP_978602.1	Differs from Rv2496c by 1aa, S201G
YP_978608.1	Differs from Rv2502c by 2aa, S77G, L343F
YP_978611.1	activates fatty acids by binding to coenzyme A
YP_978617.1	3'-5' exoribonuclease specific for small oligoribonuclotides
YP_978620.1	Differs from Rv2513 by 1aa, K122T
YP_978626.1	Identical to Rv2519 but differs from Mb2548 by 1aa, G173A, due to 2bp substitution at position equivalent to Mycobacterium bovis 2803099-2803100 cc-gg
YP_978628.1	Differs from Mb2550 by 1aa, V122M
YP_978630.1	Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids
YP_978635.1	Differs from Rv2528c by 1aa, L94P, and Mb2557c by 2aa, L94P, E259Q
YP_978636.1	Differs from Mb2558 by 1aa, G94E
YP_978641.1	Regulates rRNA biosynthesis by transcriptional antitermination
YP_978642.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_978645.1	catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis
YP_978646.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_978647.1	catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_978648.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_978650.1	Differs from Rv2542 by 1aa, A211T
YP_978652.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, there is a 656 bp insertion, relative to Mycobacterium tuberculosis strain H37Rv, which leads to lppR gene, probably by duplication of llpA or lppB
YP_978661.2	AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_978663.1	similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function
YP_978664.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_978668.1	Differs from Rv2559c by 1aa, D317G
YP_978669.1	Differs from Rv2560 by 1aa, L210V
YP_978670.1	In Mycobacterium tuberculosis strain H37Rv, Rv2561 and Rv2562 exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base deletion (g-*) results in a single product which is more similar to Rv2561
YP_978674.1	In Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 2 bp deletion (gc-*) splits Rv2566 into 2 parts. Differs from first part of Rv2566 by 3aa, S10G, S270A, L315V and from Mb2595 by 1aa, L315V
YP_978675.1	In Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 2 bp deletion (gc-*) splits Rv2566 into 2 parts; Differs from Rv2566 by 2aa, P67L, E326G, and from Mb2596 by 1aa, E326G
YP_978676.1	Differs from Rv2567 by 1aa, R645Q
YP_978680.1	Differs from Rv2571c and Mb2601c by 1aa, C68R
YP_978681.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_978682.1	ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis
YP_978686.1	In Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG Pasteur, Rv2577 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (g-a) splits Rv2577 into 2 parts, Mb2607 and Mb2608
YP_978688.1	catalyzes the cleavage of carbon-halogen bonds in aliphatic compounds forming a primary alcohol and a halide
YP_978689.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_978691.1	Differs from Rv2582 by 1aa, F66V
YP_978693.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_978694.1	Differs from Rv2585c by 1aa, S462C
YP_978695.1	forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF
YP_978696.1	part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane
YP_978697.1	member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex
YP_978698.1	catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate
YP_978699.1	Differs from Rv2590 by 1aa, Y309F, and from Mb2621 by 1aa, A1106T
YP_978700.1	Differs from Rv2591 by extra 3aa resulting from same 9 bp in-frame insertion as in Mycobacterium bovis (*-ggcggcacc) and by 2aa S415G, D463G
YP_978701.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_978702.1	plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_978703.1	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_978705.1	Differs from Rv2596 by 1aa, R77C
YP_978708.1	Differs from Rv2599 by 1aa, I12S
YP_978709.1	First 64 aa identical to N-terminal part of Rv2600 and Mb2631 but then frameshifts due to 10bp deletion at position equivalent to Mycobacterium bovis coordinates 2895640-2895649. Results in BCG Pasteur orthologs of Mb2631 and Rv2600 being in two parts
YP_978710.1	All 59aa are identical to C-terminal part of Rv2600 and Mb2631 owing to frameshifts due to 10bp deletion at position equivalent to Mycobacterium bovis coordinates 2895640-2895649. Results in BCG Pasteur orthologs of Mb2631 and Rv2600 being in two parts, both of which encode hydrophobic proteins
YP_978711.1	catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine
YP_978715.1	with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate
YP_978716.1	Differs from Rv2605c by 1aa, L85F
YP_978717.1	with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate
YP_978718.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate
YP_978719.1	Differs from Rv2608 by 1aa, S281P
YP_978722.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA
YP_978725.1	catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr)
YP_978726.1	Differs from Mb2647 by 1aa, R57H
YP_978727.1	In Mycobacterium bovis, a 9 bp in-frame insertion (*-ccgccgttt) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 461 aa). In Mycobacterium bovis BCG Pasteur, a 7bp deletion at position corresponding to M. bovis 2944835-2944841 splits PE_PGRS45 in two parts
YP_978728.1	In Mycobacterium bovis, a 9 bp in-frame insertion (*-ccgccgttt) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 461 aa). In Mycobacterium bovis BCG Pasteur, a 7bp deletion at position corresponding to M. bovis 2944835-2944841 splits PE_PGRS45 in two parts. Differs from Rv2615c by 1aa, V40A
YP_978729.1	Differs from Rv2616 by 1aa, I72V
YP_978734.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 3 bp deletion (ggg-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (223 aa versus 224 aa) due to deletion of 1aa after position 194
YP_978740.1	Differs from Rv2627c by 1aa, G104R
YP_978741.1	Differs from Rv2628 by 1aa, L59S, and from Mb2661 by 1aa, P68R
YP_978747.1	In Mycobacterium bovis BCG Pasteur, an in-frame insertion of 66 bp, leads to a longer product compared to Mycobacterium bovis and Mycobacterium tuberculosis strain H37Rv (800 aa versus 778 aa)
YP_978756.1	Differs from Rv2643 by 1 aa A455V
YP_978758.1	In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a large 10982 bp deletion (RD11 region) leads to deletion of genes between Rv2645 and Rv2659c compared to Mycobacterium tuberculosis strain H37Rv
YP_978767.1	Differs from Rv2668 by 2aa R3H and K162E
YP_978771.1	Differs from Rv2672 by 1aa D317H
YP_978776.1	catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX
YP_978777.1	catalyzes the formation of coproporphyrinogen from uroporphyrinogen III
YP_978778.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_978780.1	Differs from Rv2681 by 1aa V196A
YP_978781.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_978782.1	Differs from Rv2683 by 1aa, S84L
YP_978784.1	Differs from Rv2685 by 1aa, G378A and Mb2704, by 1aa, G393C
YP_978787.1	Differs from Rv2688c by 1aa, T156P
YP_978789.1	In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a single base transition (t-c) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (663 aa versus 657 aa)
YP_978790.1	Differs from Rv2691 by 1aa, A117T
YP_978791.1	Differs from Rv2692 by 1aa, V133I
YP_978793.1	Differs from Rv2694c by 1aa, S68R
YP_978795.1	Differs from Rv2696c by 1aa, N164D
YP_978796.1	catalyzes the formation of dUMP from dUTP
YP_978801.1	Differs from Rv2702 by 1aa, T203I
YP_978802.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YP_978808.1	Differs from Rv2709 by 1aa, S35T
YP_978809.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase
YP_978812.1	catalyzes the conversion of NADPH to NADH
YP_978813.1	Differs from Rv2714 by 2aa, W181S, A245V
YP_978818.1	Differs from Rv2719c by 1aa, H124Y
YP_978819.1	Represses a number of genes involved in the response to DNA damage
YP_978820.1	Differs from Rv2721c and Mb2740c by 2aa, S251G, A326T
YP_978823.1	Differs from Rv2724c by 1aa, T127I, and from Mb2743c by 1aa, P33A
YP_978824.1	Differs from Rv2725c and Mb2744c by 1aa, D218G
YP_978825.1	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_978826.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_978828.1	Differs from Rv2729c by 3aa, L41F, E202A, V266A
YP_978832.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_978835.1	binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities
YP_978836.1	these RecA proteins contain inteins; catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_978842.1	In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, deletions of a single base (t-*) and of 84 bp (H37Rv2.3054724-3054807-*) leads to a shorter product with a different 5' start compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Also has lost 174 bp compared to Mb2761
YP_978843.1	In Mycobacterium tuberculosis strain H37Rv, Rv2742c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a 23 bp insertion splits Rv2742c into two parts
YP_978844.1	In Mycobacterium tuberculosis strain H37Rv, Rv2742c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a 23 bp insertion splits Rv2742c into two parts
YP_978846.1	Differs from Mb2765c by 1aa, K153Q
YP_978849.1	catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis
YP_978852.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_978855.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_978856.1	flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor
YP_978858.1	Differs from Rv2756c by 1aa, P306L
YP_978864.1	In Mycobacterium tuberculosis strain H37Rv, Rv2762c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transition (c-t) splits Rv2762c into 2 parts
YP_978865.1	In Mycobacterium tuberculosis strain H37Rv, Rv2762c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base transition (c-t) splits Rv2762c into 2 parts
YP_978867.1	ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived
YP_978868.1	Differs from Rv2765 and Mb2787 by 1aa, I129M
YP_978869.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_978870.1	Differs from Rv2767c and Mb2789c by 1aa, L26S
YP_978871.1	Differs from Rv2768c by 1aa, R263P
YP_978872.1	Differs from Rv2769c by 2aa, S54P, M270V
YP_978873.1	Differs from Rv2770c by 1aa, S194F
YP_978874.1	Differs from Rv2771c by 1aa, P80L
YP_978876.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_978882.1	In Mycobacterium bovis, a 24 bp deletion leads to a shorter product compared to its homolog in Mycobacterium bovis BCG Pasteur, and Mycobacterium tuberculosis strain H37Rv (171 aa versus 179 aa); Differs from Rv2779c by 1aa, I9M, and 8 aa longer than Mb2801c
YP_978883.1	In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis BCG Pasteur, and in Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits ald into 2 parts, ald_a and aldb
YP_978884.1	In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis BCG Pasteur, and in Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits ald into 2 parts, ald_a and aldb
YP_978889.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_978890.1	catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities
YP_978891.1	Differs from Rv2787 and Mb2810 by 1aa, P78T
YP_978892.1	Differs from Rv2788 by 1aa, A137D
YP_978896.1	Differs from Mb2815c by 2aa, A17V, T80E
YP_978897.1	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs
YP_978898.1	Differs from Rv2794c by 1aa, V87M
YP_978900.1	Differs from Rv2796c by 1aa, F159C
YP_978903.1	In Mycobacterium bovis, a 3 bp insertion (*-ggt) leads to a slightly longer product compared to its homolog in Mycobacterium bovis BCG Pasteur and Mycobacterium tuberculosis strain H37Rv (210 aa versus 209 aa)
YP_978908.1	Differs from Rv2804c by 2aa, T58A, V74A
YP_978909.1	Differs from Rv2805 by 1aa, D4G
YP_978911.1	Differs from Rv2807 by 2aa, V72E, T349M, and from Mb2830 by 1aa, T349M
YP_978913.1	Differs from Rv2809 by 1aa, P46T
YP_978915.1	In Mycobacterium bovis BCG Pasteur and in Mycobacterium tuberculosis strain H37Rv, Rv2812 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (tg-*) splits Rv2812 into 2 parts, Mb2835 and Mb2836. Differs from Rv2812 by 1 aa, G395R
YP_978916.1	Differs from Rv2813 by 1aa, V76I
YP_978921.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transition (c-t) introduces a premature stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (336 aa versus 382 aa)
YP_978926.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 9 bp insertion (*-cggcgatgt) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_978927.1	Differs from Mb2848c by 1aa H56P
YP_978928.1	Differs from Rv2825c by 5aa, E2K, C162S, L189V, Q192T, E195A
YP_978931.1	Differs from Mb2852c by 1aa E58A
YP_978934.1	Differs from Rv2830c by 1aa, V56A
YP_978935.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_978936.1	Differs from Rv2832c and Mb2856c by 1aa, L235F
YP_978937.1	In mycobacterium bovis BCG Pasteur, a single base mutation (T->A) at corresponding position 3093840, in Mycobacterium tuberculosis H37Rv strain, leads to a stop codon and break ugpB in two parts. Differs from Rv2833c by 2aa, I111S, L174P
YP_978939.1	In Mycobacterium bovis BCG Pasteur and Mycobacterium tuberculosis strain H37Rv, ugpA exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) splits ugpA into 2 parts, ugpAa and ugpAb
YP_978940.1	Differs from Rv2836c by 2aa, H157Q, L350P, and from Mb2861c by 1aa, H157Q
YP_978942.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_978943.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_978945.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_978946.1	in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins
YP_978949.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_978950.1	Differs from Rv2846c by 1aa, R15T
YP_978952.1	responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid
YP_978953.1	catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide
YP_978954.1	Differs from Rv2850c by 2aa, Q273R, S446G
YP_978956.1	malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate
YP_978957.1	Differs from Rv2853 by 3aa, N227K, G228R, D232G, and 18aa deletion, and from Mb2878 by 1aa, D184G, and same 18aa deletion
YP_978959.1	catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide
YP_978967.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential
YP_978968.1	Differs from Rv2862c by 2aa, P18R, R50C
YP_978974.1	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis
YP_978975.1	Differs from Mb2894c by 1aa, T330A, and from Rv2869c by 2aa, F259V, T330A
YP_978976.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_978978.1	Differs from Rv2872 and Mb2897 by 1aa, T72A
YP_978980.1	Differs from Rv2874 by 1aa, D672Y
YP_978982.1	Differs from Mb2901 by 1aa, D101G, and from Rv2876 by 2aa, R44W, D101G
YP_978983.1	Differs from Rv2877c by 1aa, H35Y
YP_978985.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_978987.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_978988.1	Catalyzes the phosphorylation of UMP to UDP
YP_978990.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-c) leads to a truncation resulting in a shorter product compared to its homolog in Mycobacterium tuberculosis stain H37Rv (439 aa versus 460 aa)
YP_978993.1	catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia
YP_978994.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_978995.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_978999.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_979001.1	Differs from Rv2896c by 2aa, G57E, A153S
YP_979004.1	involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth
YP_979007.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_979008.1	Differs from Rv2903c by 1aa, N2564D
YP_979009.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_979011.1	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_979012.1	Essential for efficient processing of 16S rRNA
YP_979014.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_979022.1	Differs from Rv2917 by 1aa, L594R
YP_979023.1	catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; also involved in adenylylating and deadelnylyating GlnK
YP_979027.1	Differs from Rv2922c by 2aa, R364L, G698R
YP_979028.1	catalyzes the hydrolysis of acylphosphate
YP_979030.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_979031.1	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_979036.1	activates fatty acids by binding to coenzyme A
YP_979037.1	Differs from Rv2931 at several positions
YP_979038.1	Differs from Mb2957 and Rv2932 at several positions
YP_979040.1	Differs from Rv2934 at several positions
YP_979041.1	Differs from Rv2935 at several positions
YP_979042.1	Differs from Rv2936 by 1aa, D309H
YP_979045.1	required for PDIM synthesis; phthiocerol and phthiodiolone dimycocerosate esters are scaffolds used for virulence-enhancing lipids; proposed to catalyze diesterification of phthiocerol and phthiodolone with mycocerosate; functions in polyketide synthesis
YP_979047.1	activates fatty acids by binding to coenzyme A
YP_979052.1	In Mycobacterium tuberculosis H37Rv, pks1 and pks15 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-g) results in a single product that is more similar to pks1. Differs from Rv2946c by 2aa, G1779V, V1859A, and from Rv2947c by 2aa, A333V, R374G
YP_979053.1	activates fatty acids by binding to coenzyme A
YP_979055.1	activates fatty acids by binding to coenzyme A
YP_979059.1	Differs from Rv2954c and Mb2978c by 1aa, Q194R
YP_979060.1	Differs from Rv2955c by 1aa, H27R
YP_979061.1	Differs from Rv2956 by 1aa, T237I
YP_979063.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_979069.1	produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine
YP_979070.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_979072.1	biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate
YP_979077.1	Differs from Rv2971 by 1aa, H152N
YP_979079.1	catalyzes branch migration in Holliday junction intermediates
YP_979080.1	In Mycobacterium tuberculosis H37Rv, Rv2975c and Rv2974c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 2 bp deletion (cg-*) results in a single product that is more similar to Rv2974c
YP_979081.1	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YP_979082.1	catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP
YP_979084.1	Differs from Rv2979c by 3aa, R14P, A79T, G151D
YP_979086.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_979087.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_979089.1	catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate
YP_979091.1	Differs from Rv2986c and Mb3010c by 9aa deletion at position 137
YP_979092.1	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_979093.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_979095.1	Differs from Mb3014c by 1aa, A217E
YP_979096.1	Differs from Rv2991 by 1aa, T93A
YP_979097.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_979100.1	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_979101.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_979102.1	Differs from Rv2997 by 1aa S108C
YP_979105.1	Differs from Rv2999 by 1aa, L212M
YP_979107.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_979108.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_979109.1	acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate
YP_979112.1	Differs from Rv3006 by 1aa, D219G
YP_979115.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_979116.1	catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis
YP_979117.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_979118.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain
YP_979120.1	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB
YP_979124.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 56 bp deletion leads to a product slightly different at the Nh2-terminus part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (434 aa versus 437 aa). Differs from Rv3018c by 1aa, A53V, and Mb3043c by 1aa, L328V
YP_979128.1	In Mycobacterium Mycobacterium tuberculosis H37Rv, PPE47 and PPE48 exist as 2 separate genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-g) leads to a single product
YP_979130.1	Differs from Rv3023c by 1aa T9A
YP_979131.1	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_979135.1	Differs from Rv3028c by 1aa, V312A
YP_979139.1	Differs from Rv3032 and Mb3058 by 1aa, P380Q
YP_979144.1	Differs from Mb3062c by 1aa, Q63R
YP_979145.1	Differs from Rv3037c by 1aa, A7D
YP_979147.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_979150.1	Differs from Rv3042c by 2aa, S70A, E116G
YP_979156.1	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE
YP_979159.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_979160.1	in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF
YP_979165.1	involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
YP_979168.1	Differs from Mb3085 by 1aa, E44K and Rv3059 by 2aa, E44K, G445D
YP_979170.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium tuberculosis strain H37Rv, fadE22 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits fadE22 into 2 parts, fadE22a and fadE22b. Differs from Mb3087c and from Rv3061c by 2aa, E488K, C497S
YP_979171.1	catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA
YP_979172.1	Differs from Rv3063 by 3aa, C402G, S559R, P600L
YP_979176.1	Differs from Rv3067 and Mb3094 by 1aa A3T
YP_979177.1	catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate
YP_979178.1	may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling
YP_979179.1	may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling
YP_979186.1	Differs from Rv3077 by 1aa R311G
YP_979189.1	Differs from Rv3080c by 1aa, V217A
YP_979190.1	Differs from Rv3081 and Mb3108 by 1aa, A108V
YP_979191.1	Differs from Rv3082c by 1aa, C322R
YP_979192.1	Differs from Mb3110 by 1aa, S81I and from Rv3083 by 2aa, S81I, I94V
YP_979193.1	Differs from Rv3084 and Mb3111 by 1aa, G276S
YP_979196.1	Differs from Rv3087 by 1aa, V447L, and from Mb3114 by 1aa, T158A
YP_979201.1	Differs from Mb3119c by 1 aa, I237M
YP_979202.1	Differs from Rv3093c by 1aa W210C
YP_979205.1	Differs from Rv3097 by 1aa G28E
YP_979206.1	Differs from Rv3097c by 1aa A58G
YP_979207.1	Differs from Rv3098c by 1aa E117D
YP_979209.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_979210.1	Differs from Rv3101c by 1aa, S171N
YP_979214.1	recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1
YP_979215.1	Differs from Rv3106 by 2aa, I141V, D385N
YP_979217.1	Differs from Mb3135 by 1aa I145V
YP_979218.1	Differs from Mb3136 by 1aa, T324A
YP_979220.1	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis
YP_979222.1	Differs from Rv3113 by 3aa, C11W, E134G, R191L
YP_979223.1	Differs from Rv3114 by 1aa, P11S
YP_979226.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a large deletion of 2775 bp (RD12) leads to the loss of the COOH part of cysA3, the following CDSs, sseC1, moaE1, Rv3120 and a large part of cyp141 except the COOH end, compared to the homolog in Mycobacterium tuberculosis strain H37Rv
YP_979227.1	Differs from Rv3122 by 1aa, S156R
YP_979228.1	Differs from Rv3123 by 1aa, Q40R
YP_979229.1	Differs from Rv3124 and Mb3147 by 1aa, G159E
YP_979230.1	In Mycobacterium bovis BCG Pasteur, PPE49 has incurred a single base deletion in codon 272 compared to Rv3125c and Mb3148c leading to frameshift, and two products of 282 and 104 aa, compared to 391 in others
YP_979231.1	In Mycobacterium bovis BCG Pasteur, PPE49 has incurred a single base deletion in codon 272 compared to Rv3125c and Mb3148c leading to frameshift, and two products of 282 and 104 aa, compared to 391 in others. Differs from Rv3125c by 1aa, V38A
YP_979233.1	Differs from Rv3127 by 1aa, C95F
YP_979234.1	In Mycobacterium tuberculosis strain H37Rv, Rv3128c exists as a single gene with an in-frame amber stop codon. In Mycobacterium bovis, Rv3128c is split into 2, Mb3151c and Mb3152c
YP_979235.1	In Mycobacterium tuberculosis strain H37Rv, Rv3128c exists as a single gene with an in-frame amber stop codon. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, Rv3128c is split into 2 genes; Differs from Mb3152c by 1aa, V166G
YP_979239.1	Differs from Rv3132c by 1aa, T283I
YP_979242.1	In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a large 1337 bp insertion (I-RD08) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (381 aa versus 132 aa). Differs from Mb3159 by 1aa, K213E
YP_979244.1	Differs from Rv3137 by 1aa, L168P
YP_979245.1	Differs from Rv3138 by 2aa, N110S, P271T, and from Mb3162 by 2aa, F257S, P270L
YP_979249.1	Differs from Mb3166c by 1aa, H133Q
YP_979251.1	Differs from Rv3144c by 1aa, G226S
YP_979252.1	Catalyzes the transfer of electrons from NADH to quinone
YP_979253.1	The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen
YP_979254.1	Catalyzes the transfer of electrons from NADH to quinone
YP_979255.1	Catalyzes the transfer of electrons from NADH to quinone
YP_979256.1	Catalyzes the transfer of electrons from NADH to quinone
YP_979258.1	Catalyzes the transfer of electrons from NADH to quinone
YP_979259.1	Catalyzes the transfer of electrons from NADH to quinone
YP_979260.1	Catalyzes the transfer of electrons from NADH to quinone
YP_979261.1	Catalyzes the transfer of electrons from NADH to quinone
YP_979262.1	Catalyzes the transfer of electrons from NADH to quinone
YP_979263.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_979264.1	Catalyzes the transfer of electrons from NADH to quinone
YP_979265.1	Catalyzes the transfer of electrons from NADH to quinone
YP_979266.1	In Mycobacterium bovis BCG pasteur and Mycobacterium bovis, albeit a 2146 bp insertion occurs overlapping the NH2-terminal part, this leads to an equivalent product, compared to its homolog in Mycobacterium tuberculosis strain H37Rv; Differs from Rv3159c by 2aa, deletion of A64, V87A, and from Mb3183c by 1aa, V87A
YP_979267.1	In Mycobacterium bovis BCG pasteur and Mycobacterium bovis, an insertion of 2146 bp exists between PPE53 and Rv3160c compared to Mycobacterium tuberculosis strain H37Rv. This leads to an additional gene, PPE70 equivalent to MT3248 from Mycobacterium tuberculosis strain CDC1551. Differs from Mb3184c by 1aa, deletion of A64
YP_979269.1	Differs from Rv3161c by 1aa, L62V
YP_979270.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (t-*), leads to a longer product with different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_979271.1	Differs from Mb3188c by 1aa, D341E
YP_979272.1	Differs from Mb3189c by 1aa, E20G
YP_979274.1	Differs from Rv3166c and Mb3191c by 1aa, A202S
YP_979276.1	Differs from Mb3193 by 1aa, W65R
YP_979279.1	Differs from Rv3171c by 1aa, M201T
YP_979282.1	Differs from Rv3174 by 1aa, A9V
YP_979283.1	catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia
YP_979284.1	In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mesT into 2 parts, mesTa and mesTb
YP_979285.1	In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mesT into 2 parts, mesTa and mesTb
YP_979296.1	Differs from Rv3190c by 2aa, P138L, A330V
YP_979299.1	Differs from Rv3193c by 2aa, E356Q, Q843R, and from Mb3215c by 1aa, E356Q
YP_979308.1	can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates
YP_979309.1	Differs from Rv3200c by 1aa, D12N
YP_979311.1	Differs from Rv3202c by 1aa, A748V
YP_979314.1	Differs from Rv3204 by 1aa, A34T
YP_979316.1	The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation
YP_979317.1	Differs from Rv3207c by 1aa, N157D
YP_979322.1	Differs from Mb3237 by 1aa, V17A
YP_979323.1	Differs from Mb3238 by 1aa, G225D, and from Rv3212 by 2aa, G225D, A250V
YP_979324.1	Differs from Rv3213c by 1aa, E144K
YP_979325.1	forms a homodimer in Mycobacterium tuberculosis; belongs to the dPGM superfamily
YP_979331.1	Differs from Rv3220c by 1aa, N47D
YP_979335.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response
YP_979339.1	Differs from Rv3225c by 1aa T306A
YP_979341.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_979342.1	Differs from Rv3228, Mb3257 and BCG_3351 by 1aa, D169G
YP_979344.1	Differs from Rv3230c by 1aa, C105R
YP_979345.1	IN DU2, the second copy (BCG_3355c) is truncated
YP_979347.1	In Mycobacterium tuberculosis H37Rv, Rv3234c and Rv3233c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-g) leads to a single product that is more similar to Rv3234c
YP_979352.1	Differs from Mb3267c by 1aa, R867H
YP_979353.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_979355.1	Differs from Rv3242c and Mb3270c by 1aa, S89L
YP_979357.1	Differs from Rv3244c by 2aa, G142D, L394S
YP_979358.1	Differs from Rv3245c by 1aa, L517M
YP_979360.1	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP)
YP_979361.1	catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine
YP_979370.1	converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells
YP_979374.1	catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO)
YP_979375.1	catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0)
YP_979378.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, an in-frame deletion of 12 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (297 aa versus 301 aa)
YP_979379.1	Differs from Rv3266c by 1aa, P257S
YP_979385.1	Differs from Mb3300 by 1aa, R259G, and from Rv3272 by 2aa, R259G, S347N
YP_979388.1	Differs from Rv3275c by 1aa, R125G
YP_979389.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_979390.1	Differs from Rv3277 by 1 aa, L272S
YP_979391.1	Differs from Rv3278c by 1aa, K160E
YP_979392.1	Differs from Rv3279c by 1aa, N211D
YP_979393.1	Differs from Rv3280 by 1aa, A448V
YP_979394.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, an in-frame deletion of 63 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (156 aa versus 177 aa). Loss of tandem repeat SRVSGTNEVSDGNETNNPAPV
YP_979395.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_979396.1	Differs from Mb3311 by 1aa, G170D
YP_979399.1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is a general stress response regulator; expressed in stationary phase and under nitrogen depletion and cold shock
YP_979403.1	catalyzes the formation of 2-aminoadipate 6-semiladehyde and glutamate from lysine and 2-oxoglutarate
YP_979404.1	Differs from Rv3291c by 1aa, V22A
YP_979406.1	Differs from Rv3293 by 1aa, C273G
YP_979409.1	Differs from Rv3296 by 3aa, M719V, N818D, E1059K
YP_979412.1	Differs from Rv3299c by 1aa, S204G
YP_979413.1	Differs from Mb3328c by 1aa, D52N
YP_979414.1	Differs from Rv3301c and Mb3329c by 1aa, S74A
YP_979416.1	In Mycobacterium bovis BCG Pasteur, Mb3333c is truncated compared to its homologs in Mycobacterium tuberculosis strain H37Rv (Rv3213c) and Mycobacterium bovis AF2122/97 (Mb3239c). It contains one endpoint of BCG-specific tandem duplication region, DU2. Differs from Rv3213c by 2aa, E144K and P198L
YP_979417.1	forms a homodimer in Mycobacterium tuberculosis; belongs to the dPGM superfamily
YP_979423.1	Differs from Rv3220c by 1aa, N47D
YP_979427.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response
YP_979431.1	Differs from Rv3225c by 1aa, T305A
YP_979433.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_979434.1	Differs from BCG_3258 by 1aa, G169D
YP_979436.1	Differs from Rv3230c by 1aa, C105R
YP_979437.1	Internal deletion of DU2 leads to a truncated copy of Rv3231c and of Rv3290c
YP_979438.1	Differs from Rv3291c by 1aa, V22A
YP_979440.1	Differs from Rv3293 by 1aa, C273G
YP_979443.1	Differs from Rv3296 by 3aa, M719V, N818D, E1059K
YP_979446.1	Differs from Rv3299c by 1aa, S204G
YP_979447.1	Differs from Mb3328c by 1aa, D52N
YP_979448.1	Differs from Rv3301c and Mb3329c by 1aa, S74A
YP_979450.1	catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity
YP_979454.1	catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation
YP_979455.1	Differs from Rv3308 by 1aa, G440S
YP_979456.1	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_979457.1	Differs from Rv3310 by 1aa, A171T
YP_979461.1	catalyzes the formation of inosine from adenosine
YP_979462.1	Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
YP_979463.1	Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis
YP_979465.1	Differs from Rv3317 by 1aa, L54V
YP_979466.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol
YP_979467.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase
YP_979472.1	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis
YP_979473.1	Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv
YP_979474.1	Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv
YP_979475.1	Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv but present in CDC1551 (CDS not annotated)
YP_979476.1	Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv but present in CDC1551 (CDS not annotated)
YP_979477.1	Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv
YP_979478.1	Belongs to the RvD5 region. Absent from Mycobacterium tuberculosis strain H37Rv
YP_979480.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription
YP_979481.1	Differs from Rv3329 by 1aa, H122Q
YP_979483.1	Differs from Mb3364 by 5aa in-frame deletion at position 465, and from Rv3331 by same deletion and 1aa, L423P
YP_979488.1	Differs from Rv3335c and Mb3368c by 1aa, V86A
YP_979489.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_979490.1	In Mycobacterium tuberculosis strain H37Rv, Rv3337 and Rv3338 exist as 2 genes with an overlap region between them. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-t) leads to a single product
YP_979491.1	Converts isocitrate to alpha ketoglutarate
YP_979492.1	catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol
YP_979493.1	Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine
YP_979495.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 3555 bp in-frame deletion (RD19) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Mb3375c by 1aa A514V and from Rv3343c by several transitions
YP_979496.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS50 and PE_PGRS49 exists as a single gene. In Mycobacterium bovis, a single base deletion (g-*) splits PE_PGRS50 into 2 parts, PE_PGRS50a and PE_PGRS50b and a single base deletion (c-*) leads to PE_PGRS49 and PE_PGRS50b existing as a single product. In Mycobacterium bovis BCG Pasteur, the first deletion is absent leading to an uniq single gene comprising PE_PGRS50 and PE_PGRS49
YP_979498.1	In Mycobacterium tuberculosis strain H37Rv, PPE55 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits PPE55 into 2 parts, PPE55a and PPE55b. Differs from Rv3347c by many aa substitutions and from Mb3380c by 1 aa, P1089S
YP_979501.1	In Mycobacterium tuberculosis strain H37Rv, PPE56 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, 2 frameshifts due to single base transversion (c-a) and a single base deletion (g-*) splits PPE56 into 3 parts, PPE56a, PPE56b and PPE56d; Differs from Rv3350c and Mb3385c by 2aa deletion at position 291
YP_979505.1	Differs from Rv3354 by 1aa, A112V
YP_979507.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_979515.1	Differs from Rv3364c and Mb3399c, by 1aa, L22P
YP_979518.1	In Mycobacterium bovis, insertions of 105 bp and of 9 bp (*-ggcagcggt) lead to longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (626 aa versus 588 aa). In Mycobacterium bovis BCG Pasteur, there is no 105 bp insertion but the 9 bp insertion is present at codon 404. Differs also from Rv3367 by 1aa, S412G
YP_979521.1	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase.
YP_979522.1	Differs from Rv3371 by 2aa, G339R, V368I
YP_979524.1	In Mycobacterium tuberculosis H37Rv, echA18 and echA18' exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transversion (t-g) leads to a single product
YP_979527.1	In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a frameshift due to a 4 bp to 3 bp substitution (caat-aac) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_979528.1	Differs from Rv3378c and Mb3412c by 1aa, A137V
YP_979529.2	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_979531.1	Differs from Rv3383c by 1aa, G132V
YP_979536.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, insertions of 60 bp and 78 bp, and deletions of 75 bp and 9 bp (cggcggcgc-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (750 aa and 749 aa versus 731 aa). Differs from Mb3420 by 1aa insertion, A205
YP_979537.1	Differs from Mb3421c by 1aa, P172L
YP_979540.1	Differs from Rv3392c by 1aa, S112N
YP_979543.1	Differs from Rv3395c by 2aa, V3A, M104V
YP_979545.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_979548.1	Differs from Rv3399 by 1aa, E330A
YP_979550.1	Differs from Mb3434 by 1aa, R658H
YP_979551.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transversion (c-g) leads to a shorter product. Differs from Mb3436c by 1aa, R154C
YP_979557.1	Differs from Rv3408 by 1aa, L46S
YP_979559.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_979560.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_979563.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase
YP_979566.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth
YP_979567.1	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_979568.1	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_979572.1	converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer
YP_979574.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a large deletion of 4926 bp (RD6) leads to the loss of the COOH part of PPE57, and the following CDSs, PPE58, Rv3427c, Rv3428c and the NH2-part of PPE59 compared to Mycobacterium tuberculosis strain H37Rv
YP_979575.1	Differs from Mb3460c by 1aa, R233H
YP_979578.1	Differs from Mb3463c by 1aa, A436 deleted, and from Rv3433c by 2aa, A436 deleted, A442S
YP_979579.1	Differs from Mb3464c by 1aa, A193T
YP_979581.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_979582.1	Differs from Rv3437 by 1aa P84L
YP_979586.1	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_979587.1	forms a direct contact with the tRNA during translation
YP_979588.1	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_979592.1	Differs from Rv3444c by 1 aa, G1082S and Mb3477c by 1 aa G1159S
YP_979593.1	Differs from Mb3478 by 1aa A265D
YP_979596.1	Differs from Rv3451 and Mb3481 by deletion of 1aa, 262R
YP_979598.1	In Mycobacterium tuberculosis H37Rv, Rv3453 and Rv3454 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (t-*) results in a single product that is more similar to Rv3454. Differs from Mb3483 by 1aa, V328I
YP_979599.1	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability
YP_979600.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_979601.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_979602.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_979603.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_979604.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_979605.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif
YP_979606.1	stimulates the activities of the other two initiation factors, IF-2 and IF-3
YP_979610.1	Differs from Rv3466 by 4aa, T56A, T63A, L91R, I131V
YP_979611.1	Differs from Rv3467 by 6aa, E134K, G245A, D262G, R275H, K276N, E315K
YP_979612.1	Differs from Rv3468c by 1aa, V62I
YP_979613.1	catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate
YP_979614.1	Differs from Mb3499c by 1aa, G421E
YP_979615.1	Differs from Mb3500c by 1aa, C155W
YP_979618.1	Differs from Rv3476c by 2aa, F81L, V144A
YP_979619.1	Differs from Rv3477 by 1aa, A26V
YP_979621.1	In Mycobacterium tuberculosis strain H37Rv, Rv3479 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 713 bp deletion(RD18) splits Rv3479 into 2 parts, Mb3507 and Mb3508. Differs from Rv3479 by 1aa, R174L
YP_979622.1	In Mycobacterium tuberculosis strain H37Rv, Rv3479 exists as a single gene. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a 713 bp deletion (RD18) splits Rv3479 into 2 parts, Mb3507 and Mb3508. Differs from Rv3479 by 1aa, N344T
YP_979623.1	In Mycobacterium tuberculosis strain H37Rv, Rv3480c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (gt-*) splits Rv3480c into 2 parts, Mb3509c and Mb3510c. Differs from Rv3480c and Mb3510c by 1aa, N205D
YP_979625.1	BCG_3546c; In Mycobacterium bovis BCG Pasteur, a single base insertion (C) at position equivalent to Mycobacterium tuberculosis H37Rv position 3901442-3901443 leads to frameshift and longer product of 496 aa compared to Rv3482c, len: 260 aa
YP_979631.1	Differs from Rv3488 by 1aa, R98G
YP_979633.1	Differs from Rv3490 by 1aa, L334V
YP_979637.1	Differs from Rv3494c by 1aa, G245D
YP_979640.1	Differs from Mb3527c and Rv3497c by 1aa, P46T
YP_979645.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_979648.1	Differs from Rv3505 by 1aa V218A
YP_979649.1	activates fatty acids by binding to coenzyme A
YP_979650.1	In Mycobacterium bovis , insertions of 18 bp, 72 bp and 9 bp (*-cggcggcac), and deletions of 90 bp, 54 bp and 18 bp, and Mycobacterium bovis BCG Pasteur, insertions of 18 bp, 81 bp and 9 bp (*-cggcggcac), and deletions of 90 bp, 27 bp and 18 bp, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1360 aa and 1372 aa versus 1381 aa). Differs from Mb3537 by 2 insertions of 9aa and 3aa and by 1aa, N599D. Differs from Rv3507 by several insertions, deletions and by 2aa, N599D, G742D
YP_979651.1	In Mycobacterium bovis BCG Pasteur several insertions lead to a longer product compared to its homolog in Mycobacterium bovis (2094 aa versus 1460 aa)
YP_979652.1	thiamine-pyrophosphate requiring enzyme
YP_979654.1	In Mycobacterium tuberculosis H37Rv, PE_PGRS55 and PE_PGRS56 exist as 2 genes. In Mycobacterium bovis, a 344 bp insertion results in a single product which is more similar to PE_PGRS55. In Mycobacterium bovis BCG Pasteur two deletions of 138bp and 246 bp lead to a shorter product compared to its homolog Mycobacterium bovis (1810 aa versus 1938 aa). Also differs from Mb3541 by 3aa, D628A, D743A and D857A
YP_979656.1	In Mycobacterium bovis BCG Pasteur a deletion of 111 bp and an insertion of 360 bp lead to a longer product compared to its homolog Mycobacterium bovis. Also differs from Mb3543 by 2aa, S80L and T93A
YP_979657.1	activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence
YP_979658.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_979660.1	In Mycobacterium tuberculosis strain H37Rv, cyp142 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (c-*) splits cyp142 into 2 parts, cyp142a and cyp142b
YP_979661.1	In Mycobacterium tuberculosis strain H37Rv, cyp142 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (c-*) splits cyp142 into 2 parts, cyp142a and cyp142b
YP_979664.1	Differs from Rv3521 by 1aa D295N
YP_979665.1	Differs from Rv3522 by 1aa I324T
YP_979666.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_979677.1	catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate
YP_979678.1	catalyzes the formation of acetyl-CoA from acetalaldehyde
YP_979680.1	initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione
YP_979689.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_979691.1	Differs from Rv3548c by 1aa V218M
YP_979693.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_979694.1	Differs from Rv3551 by 1aa, S7A
YP_979698.1	Differs from Rv3555c by 1aa R268W
YP_979699.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_979702.1	Differs from Rv3559c by 1aa V222A
YP_979704.1	activates fatty acids by binding to coenzyme A
YP_979706.1	Differs from Rv3563 by 2aa R105Q and S275W
YP_979708.1	catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate
YP_979711.1	Differs from Rv3567c by 1aa T179I
YP_979712.1	Differs from Mb3599c by 1aa Q177R
YP_979714.1	Differs from Rv3570c by 1aa D18N
YP_979720.1	Differs from Rv3576 by 1aa N118D
YP_979722.1	Differs from Rv3578 by 1aa S319A
YP_979723.1	Differs from Rv3579c by 1aa, A302E. Mb3610c is longer due to frameshift and differs by 1aa V178M
YP_979724.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_979725.1	catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
YP_979726.1	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers
YP_979729.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_979730.1	non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair
YP_979731.1	Shorter than Rv3587c and Mb3618c by 1aa, P at 240
YP_979732.1	Differs from Mb3619c by 1aa I79T
YP_979737.1	Differs from Rv3593 by 2 aa, V159A, S186N
YP_979739.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (a-*) and a 27 bp insertion (*-gcgcgccggggccaccgtttccgccgg), lead to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (492 aa versus 439 aa)
YP_979742.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_979743.1	type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP
YP_979744.1	Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5)
YP_979745.1	catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine
YP_979747.1	Differs from Rv3604c by G153V
YP_979752.1	involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer
YP_979754.1	Identical to Rv3611. In Mycobacterium bovis, a 111 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis (180 aa versus 217 aa)
YP_979759.1	Differs from Rv3616c by 2aa, V4A, I192T and Mb3646c by 2aa, V4A, V153A
YP_979760.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a large 5894 bp deletion (RD8) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (171 aa versus 240 aa)
YP_979761.1	Differs by 2 aa from Rv3624c et Mb3648c A111T, N122D
YP_979764.1	Differs from Rv3627c by 2 aa, V45A, V81A
YP_979767.1	Differs from Rv3630 by 1aa, T40A
YP_979776.1	Differs from Rv3639c by 1 aa, N53K
YP_979777.1	Differs from Rv3640c by 1aa, E296G
YP_979781.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_979783.1	catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity
YP_979786.1	Differs from Rv3649 by 2aa, P93L, D677G, and from Mb3673 by D677G
YP_979790.1	In Mycobacterium tuberculosis strain H37Rv, a frameshift due to an in-frame insertion of 126 bp leads to a longer product than in Mycobacterium bovis, and in Mycobacterium bovis BCG Pasteur. Shorter than Mb3677 due to 18 bp in-frame deletion, removes 6 codons
YP_979792.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (c-*) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (99 aa versus 125 aa)
YP_979797.1	Differs from Rv3660c by 1aa, L30P
YP_979798.1	Differs from Rv3661 by 1aa, P40S
YP_979799.1	Differs from Rv3662c by 1aa, T34A
YP_979803.1	Differs from Rv3666c by 2aa, R4Q, Q443R and to Mb3690c by 1aa, E451G
YP_979804.1	Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA
YP_979808.1	Differs from Rv3671c by 3aa, T165N, L359F, V363I and from Mb3695c by 3aa, T165N and L359F
YP_979813.1	Differs from Rv3676 and Mb 3700 by 2aa, P47L, K178E
YP_979823.1	Differs from Rv3685c by 1aa, Q136E
YP_979825.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, truncation at the 5' start due to a single base transversion (g-t) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (81 aa versus 122 aa)
YP_979827.1	Differs from Rv3689 by 1aa, L119V
YP_979834.1	Converts glycerol and ADP to glycerol-3-phosphate and ADP
YP_979835.1	Differs from Rv3697c by 1aa, R34G
YP_979837.1	Differs from Rv3698 by 3aa, I66M, R233P, A288V and from Mb3724 by 1aa, A288V
YP_979848.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_979849.1	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.
YP_979850.1	Protein is 190 aa longer than Rv3710, and 57 aa longer than Mb3737 due to differences in copy number of 19 codon repeat at 3'-end
YP_979851.1	3'-5' exonuclease of DNA polymerase III
YP_979852.1	Differs from Rv3712 by 2aa, S200G, T351K
YP_979855.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_979859.1	Differs from Rv3719 by 1aa, A12T
YP_979861.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_979862.1	Differs from Rv3722c and Mb3749c by 1aa, Y314H
YP_979864.1	In Mycobacterium tuberculosis, Rv3724A and Rv3724B exist as 2 genes with an overlap region between them. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a single base deletion (t-*) leads to a single product
YP_979865.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a single base insertion (*-a) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (333 aa versus 309 aa)
YP_979866.1	Differs from Rv3726 by 1aa, S251R
YP_979867.1	Differs from Rv3727 by 1aa, M86V
YP_979868.1	Differs from Rv3728 by 1aa, R464G
YP_979869.1	Differs from Rv3729 by 2aa, I170V, S269P
YP_979871.1	catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth
YP_979876.1	Differs from Rv3736 and Mb3763 by 1aa, K76E
YP_979877.1	Differs from Rv3737 by 1aa, G40D
YP_979878.1	Differs from Rv3740c by 1aa, C422R
YP_979886.1	Differs from Rv3748 by 1aa, D107G
YP_979891.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transition (t-c) leads to a longer product with a different 5' start compared to its homolog in Mycobacterium tuberculosis strain H37Rv (173 aa versus 166 aa)
YP_979892.1	catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate
YP_979897.1	Differs from Rv3759c by 2aa, P85L, V176A
YP_979900.1	Differs from Rv3762c by 1aa, H345Y and from Mb3788c by 1aa, V161G
YP_979902.1	Differs from Rv3764c by 2aa, R45H, R246C
YP_979908.1	Differs from Rv3770c by 1aa, A98P
YP_979912.1	Differs from Rv3772 by 1aa, A142T
YP_979913.1	In Mycobacterium tuberculosis Rv3773c exists as a single gene. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-a) splits Rv3773c in two parts
YP_979914.1	In Mycobacterium tuberculosis strain H37Rv, Rv3773c exists as a single gene. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-a) splits Rv3773c into 2 parts
YP_979915.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_979917.1	Differs from Rv3776 by 1aa, V329M
YP_979918.1	Differs from Rv3777 by 1aa, A160V
YP_979929.1	Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation
YP_979934.1	Differs from Rv3793 by 1aa, I270T
YP_979936.1	Differs from Rv3795 by 2aa, S13N, A378E
YP_979937.1	Differs from Rv3796 by 1aa, I320T
YP_979939.1	In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur, BCG_3860 and Rv3798 exist as a single gene. In Mycobacterium bovis, a frameshift due to a 11 bp deletion splits Rv3798 into 2 parts, Mb3827 and Mb3828; In Mycobacterium bovis, a frameshift due to a 11 bp deletion splits Rv3798 into 2 parts, Mb3827 and Mb3828
YP_979941.1	Differs from Rv3800c by 2aa, G523A, N650S and from Mb3829c by 1aa, N650S
YP_979942.1	activates fatty acids by binding to coenzyme A
YP_979946.1	Differs from Rv3805c by 1aa, V327I
YP_979947.1	catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate
YP_979954.1	Differs from Rv3813c by 1aa, T83M
YP_979961.1	Differs from Rv3820c by 1aa, I463T
YP_979962.1	Differs from Rv3821 by 2aa, N106D, T120A
YP_979963.1	Corresponds to Rv3822/Mb3852 but is missing 1bp after codon 122. Differs from Rv3822 by 2aa, Y55C, T103N, in first part (and by 1aa , V92A, in the second part)
YP_979964.1	Corresponds to 3'-part of Rv3822/Mb3852 due to missing bp after codon 122. Differs from Rv3822 by 1aa, V92A (and by 2aa, Y55C, T105N, in first part
YP_979965.1	Differs from Rv3823c by 2aa, R235G, A526V
YP_979967.1	Differs from Rv3825c and Mb3855c by 1aa, G829V
YP_979968.1	activates fatty acids by binding to coenzyme A
YP_979969.1	Differs from Rv3827c by 1aa, A251T
YP_979971.1	Differs from Rv3829c by 1aa, D54E
YP_979975.1	Differs from Rv3833 by 1aa, I105V
YP_979976.1	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_979977.1	Differs from Rv3835 and Mb3865 by 1 aa, Y79N, and frameshift due to extra C in C-string that changes C-terminus
YP_979978.1	In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a single base insertion (*-g) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (116 aa versus 137 aa)
YP_979980.1	catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis
YP_979981.1	Differs from Rv3839 by 1aa, S122P
YP_979985.1	Differs from Rv3843c by 2aa, R11G, H92R
YP_979988.1	Differs from Rv3846 by 1aa, T205I
YP_979990.1	Differs from Rv3848 by 1aa, I194V
YP_979995.1	regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity
YP_980000.1	glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate
YP_980001.1	Differs from Rv3859c by 1aa, E553Q
YP_980002.1	In Mycobacterium bovis BCG Pasteur, a single base deletion leads to a shorter product compared to its homologs in Mycobacterium tuberculosis and Mycobacterium bovis
YP_980006.1	In Mycobacterium bovis BCG Pasteur, and in Mycobacterium bovis, two in-frame insertion of 36 and 12 bp, leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (418 aa versus 402 aa)
YP_980010.1	Differs from Rv3868 by 1aa, V243A
YP_980013.1	Differs from Rv3871 and Mb3901 by deletion of 101 codons after codon 480 due to BCG-specific RD1 deletion
YP_980015.1	Differs from Rv3881c by 7 codon stretch due to 1bp deletion and 1 bp insertion
YP_980017.1	Differs from Rv3883c by 1aa, A37T
YP_980018.1	Differs from Rv3884c by 1aa, G215E
YP_980019.1	Differs from Rv3885c by 1aa, P133L
YP_980021.1	In Mycobacterium bovis, a deletion of 2406 bp (RDpan) leads to the loss of the NH2 part of Rv3887c, the entire Rv3888c and the COOH part of Rv3889c compared to Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur. Differs from Mb3917c by 1aa D346G
YP_980022.1	Has no counterpart in Mycobacterium bovis owing to deletion of 2405bp between positions 4307384..4307385
YP_980023.1	Has no counterpart in Mycobacterium bovis owing to deletion of 2405bp between positions 364165-364166
YP_980024.1	In Mycobacterium bovis, a deletion of 2406 bases leads to the loss of the NH2 part of Rv3887c, the entire Rv3888c and the COOH part of Rv3889c compared to Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur
YP_980025.1	In Mycobacterium bovis BCG Pasteur, and in Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (124 aa versus 95 aa)
YP_980026.1	Differs from Rv3891c by 1aa, A49T
YP_980027.1	Differs from Rv3892c by 2aa, K19T, I206M and from Mb3921c by 1aa I206M
YP_980029.1	In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-c), splits Rv3894c into 2 parts
YP_980030.1	In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-c), splits Rv3894c into 2 parts. Differs from first part of Rv3984c by 1aa, P258R
YP_980031.1	Differs from Rv3895c by 1aa, G356D
YP_980032.1	Differs from Rv3896c by 3aa, G83D, V186I, K193Q, and by frameshift due to 1bp deletion leading to shorter product (288aa versus 302aa)
YP_980033.1	In Mycobacterium tuberculosis, Rv3898c and Rv3897c exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base transition (t-c) leads to a single product
YP_980034.1	In Mycobacterium tuberculosis, Rv3899c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur a frameshift due to a single base deletion (c-*) splits Rv3899c into 2 parts, Mb3928c and Mb3929c with the former being the more likely product
YP_980035.1	Differs from Rv3900c by 1aa, A18P
YP_980036.1	Differs from Rv3901c by 1aa, W21L, and frameshift due to 2bp deletion at 3'-end, and from Mb3931c by frameshift only
YP_980039.1	Differs from Rv3904c by 1aa, V82M
YP_980040.1	In Mycobacterium bovis, and M.bovis BCG Pasteur, a single base transition (g-a) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (57 aa versus 103 aa)
YP_980044.1	Differs from Rv3909 by 3aa, R7G, S399N, V538A and from Mb3939 by 1aa G25A
YP_980045.1	Differs from Rv3910 by 1aa, A480V
YP_980046.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase
YP_980048.1	Differs from Rv3913 by 1aa, G57D
YP_980054.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_980055.1	Differs from Rv3920c by 1aa, W110R
YP_980056.1	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_980058.1	protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates
YP_980059.1	in Escherichia coli transcription of this gene is enhanced by polyamines