-- dump date 20140619_151521 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 410289000001 SEQ_END SEQ_END NC_008769.1 4374522 4374522 DR NC_008769.1; contig end 4374522..4374522 Mycobacterium bovis BCG str. Pasteur 1173P2 YP_976107.1 CDS dnaA NC_008769.1 1 1524 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1..1524 Mycobacterium bovis BCG str. Pasteur 1173P2 4697358 YP_976108.1 CDS dnaN_1 NC_008769.1 2052 3260 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2052..3260 Mycobacterium bovis BCG str. Pasteur 1173P2 4697407 YP_976109.1 CDS recF NC_008769.1 3280 4437 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 3280..4437 Mycobacterium bovis BCG str. Pasteur 1173P2 4695679 YP_976110.1 CDS BCG_0004 NC_008769.1 4434 4997 D Differs from Mb0004 by 1aa, S16L; hypothetical protein 4434..4997 Mycobacterium bovis BCG str. Pasteur 1173P2 4696082 YP_976111.1 CDS gyrB NC_008769.1 5123 7267 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 5123..7267 Mycobacterium bovis BCG str. Pasteur 1173P2 4695574 YP_976112.1 CDS gyrA_1 NC_008769.1 7302 9818 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 7302..9818 Mycobacterium bovis BCG str. Pasteur 1173P2 4695442 YP_976113.1 CDS BCG_0007 NC_008769.1 9914 10828 D Differs from Rv0007 by 1aa, I272V; hypothetical protein 9914..10828 Mycobacterium bovis BCG str. Pasteur 1173P2 4695440 YP_976114.1 CDS BCG_0008c NC_008769.1 11874 12311 R Differs from Rv0008c by 1aa, P145S; hypothetical protein complement(11874..12311) Mycobacterium bovis BCG str. Pasteur 1173P2 4697331 YP_976115.1 CDS ppiA_1 NC_008769.1 12468 13016 D iron-regulated peptidyl-prolyl cis-trans isomerase A ppiA 12468..13016 Mycobacterium bovis BCG str. Pasteur 1173P2 4697477 YP_976116.1 CDS BCG_0010c NC_008769.1 13222 13557 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (g-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (111 aa versus 141 aa); hypothetical protein complement(13222..13557) Mycobacterium bovis BCG str. Pasteur 1173P2 4698099 YP_976117.1 CDS BCG_0011c NC_008769.1 13713 13994 R integral membrane protein involved in inhibition of the Z-ring formation; septation inhibitor protein complement(13713..13994) Mycobacterium bovis BCG str. Pasteur 1173P2 4695508 YP_976118.1 CDS BCG_0012 NC_008769.1 14088 14876 D Differs from Rv0012 by 2aa, E105K, R233C; hypothetical protein 14088..14876 Mycobacterium bovis BCG str. Pasteur 1173P2 4699131 YP_976119.1 CDS trpG_1 NC_008769.1 14913 15611 D aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 14913..15611 Mycobacterium bovis BCG str. Pasteur 1173P2 4698875 YP_976120.1 CDS sigMa_2 NC_008769.1 18322 18912 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase; RNA polymerase sigma factor SigM 18322..18912 Mycobacterium bovis BCG str. Pasteur 1173P2 4696441 YP_976121.1 CDS BCG_0018 NC_008769.1 19005 19769 D hypothetical protein 19005..19769 Mycobacterium bovis BCG str. Pasteur 1173P2 4697289 YP_976122.1 CDS trxB2_2 NC_008769.1 19863 20870 D Differs from Rv3913 by 1aa, G57D; thioredoxin reductase trxB2 (TRXR) 19863..20870 Mycobacterium bovis BCG str. Pasteur 1173P2 4695650 YP_976123.1 CDS trxC_2 NC_008769.1 20867 21217 D thioredoxin trxC (TRX) (MPT46) 20867..21217 Mycobacterium bovis BCG str. Pasteur 1173P2 4696834 YP_976124.1 CDS BCG_0021 NC_008769.1 21327 22547 D hydrolase 21327..22547 Mycobacterium bovis BCG str. Pasteur 1173P2 4697088 YP_976125.1 CDS BCG_0022c NC_008769.1 22568 23302 R hypothetical protein complement(22568..23302) Mycobacterium bovis BCG str. Pasteur 1173P2 4695702 YP_976126.1 CDS parB_2 NC_008769.1 23592 24626 R chromosome partitioning protein parB complement(23592..24626) Mycobacterium bovis BCG str. Pasteur 1173P2 4695600 YP_976127.1 CDS parA_2 NC_008769.1 24623 25666 R chromosome partitioning protein parA complement(24623..25666) Mycobacterium bovis BCG str. Pasteur 1173P2 4697551 YP_976128.1 CDS gidB NC_008769.1 25663 26337 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(25663..26337) Mycobacterium bovis BCG str. Pasteur 1173P2 4697549 YP_976129.1 CDS BCG_0026c NC_008769.1 26469 27032 R Differs from Rv3920c by 1aa, W110R; hypothetical protein complement(26469..27032) Mycobacterium bovis BCG str. Pasteur 1173P2 4697395 YP_976130.1 CDS BCG_0027c NC_008769.1 27104 28204 R functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; preprotein translocase subunit YidC complement(27104..28204) Mycobacterium bovis BCG str. Pasteur 1173P2 4696493 YP_976131.1 CDS BCG_0028c NC_008769.1 28188 28550 R hypothetical protein complement(28188..28550) Mycobacterium bovis BCG str. Pasteur 1173P2 4697744 YP_976132.1 CDS rnpA NC_008769.1 28547 28924 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(28547..28924) Mycobacterium bovis BCG str. Pasteur 1173P2 4697864 YP_976133.1 CDS rpmH NC_008769.1 28921 29064 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(28921..29064) Mycobacterium bovis BCG str. Pasteur 1173P2 4696318 YP_976134.1 CDS dnaA NC_008769.1 29668 31191 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 29668..31191 Mycobacterium bovis BCG str. Pasteur 1173P2 4695799 YP_976135.1 CDS dnaN_2 NC_008769.1 31719 32927 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 31719..32927 Mycobacterium bovis BCG str. Pasteur 1173P2 4696807 YP_976136.1 CDS recF NC_008769.1 32947 34104 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 32947..34104 Mycobacterium bovis BCG str. Pasteur 1173P2 4697933 YP_976137.1 CDS BCG_0034 NC_008769.1 34101 34664 D Differs from Mb0004 by 1aa, S16L; hypothetical protein 34101..34664 Mycobacterium bovis BCG str. Pasteur 1173P2 4696083 YP_976138.1 CDS gyrB NC_008769.1 34790 36934 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 34790..36934 Mycobacterium bovis BCG str. Pasteur 1173P2 4696763 YP_976139.1 CDS gyrA_2 NC_008769.1 36969 39485 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 36969..39485 Mycobacterium bovis BCG str. Pasteur 1173P2 4695443 YP_976140.1 CDS BCG_0037 NC_008769.1 39581 40495 D Differs from Rv0007 by 1aa, I272V; hypothetical protein 39581..40495 Mycobacterium bovis BCG str. Pasteur 1173P2 4695441 YP_976141.1 CDS BCG_0038c NC_008769.1 41541 41978 R Differs from Rv0008c by 1aa, P145S; hypothetical protein complement(41541..41978) Mycobacterium bovis BCG str. Pasteur 1173P2 4697079 YP_976142.1 CDS ppiA_2 NC_008769.1 42135 42683 D iron-regulated peptidyl-prolyl cis-trans isomerase a ppiA 42135..42683 Mycobacterium bovis BCG str. Pasteur 1173P2 4698839 YP_976143.1 CDS BCG_0040c NC_008769.1 42889 43224 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (g-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (111 aa versus 141 aa); hypothetical protein complement(42889..43224) Mycobacterium bovis BCG str. Pasteur 1173P2 4698100 YP_976144.1 CDS BCG_0041c NC_008769.1 43380 43661 R integral membrane protein involved in inhibition of the Z-ring formation; septation inhibitor protein complement(43380..43661) Mycobacterium bovis BCG str. Pasteur 1173P2 4695661 YP_976145.1 CDS BCG_0042 NC_008769.1 43755 44543 D Differs from Rv0012 by 2aa, E105K, R233C; hypothetical protein 43755..44543 Mycobacterium bovis BCG str. Pasteur 1173P2 4698560 YP_976146.1 CDS trpG_2 NC_008769.1 44580 45278 D aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 44580..45278 Mycobacterium bovis BCG str. Pasteur 1173P2 4695708 YP_976147.1 CDS pknB NC_008769.1 45256 47136 R Ser/Thr protein kinase complement(45256..47136) Mycobacterium bovis BCG str. Pasteur 1173P2 4695829 YP_976148.1 CDS pknA NC_008769.1 47133 48428 R Ser/Thr protein kinase complement(47133..48428) Mycobacterium bovis BCG str. Pasteur 1173P2 4696549 YP_976149.1 CDS pbpA NC_008769.1 48425 49900 R penicillin-binding protein pbpA complement(48425..49900) Mycobacterium bovis BCG str. Pasteur 1173P2 4699308 YP_976150.1 CDS rodA NC_008769.1 49897 51306 R cell division protein rodA complement(49897..51306) Mycobacterium bovis BCG str. Pasteur 1173P2 4698833 YP_976151.1 CDS pstP NC_008769.1 51303 52847 R Differs from Rv0018c by 3aa, L3R, A455S, S463P; Serine/threonine phosphatase PPP complement(51303..52847) Mycobacterium bovis BCG str. Pasteur 1173P2 4697710 YP_976152.1 CDS BCG_0049c NC_008769.1 52936 53403 R hypothetical protein complement(52936..53403) Mycobacterium bovis BCG str. Pasteur 1173P2 4695696 YP_976153.1 CDS TB39.8 NC_008769.1 53527 55092 R Differs from Mb0020c by 2aa, G47R, Y250H, and from Rv0020c by 3aa, G222D, C298Y, Q378R, and deletion of 6aa (EQRGYP) at position 246; hypothetical protein complement(53527..55092) Mycobacterium bovis BCG str. Pasteur 1173P2 4697326 YP_976154.1 CDS BCG_0051c NC_008769.1 55561 56529 R Differs from Rv0021c by 1aa, P277A; hypothetical protein complement(55561..56529) Mycobacterium bovis BCG str. Pasteur 1173P2 4696748 YP_976155.1 CDS whiB5 NC_008769.1 56671 57090 R transcriptional regulatory protein whiB-like whiB5 complement(56671..57090) Mycobacterium bovis BCG str. Pasteur 1173P2 4698046 YP_976156.1 CDS BCG_0053 NC_008769.1 57243 58013 D transcriptional regulatory protein 57243..58013 Mycobacterium bovis BCG str. Pasteur 1173P2 4697344 YP_976157.1 CDS BCG_0054 NC_008769.1 58010 58843 D In Mycobacterium tuberculosis strain H37Rv, and other mycobacteria, Rv0024 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0024 into 2 parts; hypothetical protein 58010..58843 Mycobacterium bovis BCG str. Pasteur 1173P2 4697145 YP_976158.1 CDS BCG_0056 NC_008769.1 58892 59254 D Differs from Rv0025 by 1aa, L73P; hypothetical protein 58892..59254 Mycobacterium bovis BCG str. Pasteur 1173P2 4696316 YP_976159.1 CDS BCG_0057 NC_008769.1 59369 60802 D In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 4 bp insertion (*-atcg) leads to a longer protein with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (477 aa versus 448 aa). Differs from Rv0026 by 1aa, P93Q; hypothetical protein 59369..60802 Mycobacterium bovis BCG str. Pasteur 1173P2 4695476 YP_976160.1 CDS BCG_0058 NC_008769.1 60840 61157 D hypothetical protein 60840..61157 Mycobacterium bovis BCG str. Pasteur 1173P2 4698607 YP_976161.1 CDS BCG_0059 NC_008769.1 61165 61470 D hypothetical protein 61165..61470 Mycobacterium bovis BCG str. Pasteur 1173P2 4695862 YP_976162.1 CDS BCG_0060 NC_008769.1 61708 62805 D Differs from Rv0029 by 1aa, N190H; hypothetical protein 61708..62805 Mycobacterium bovis BCG str. Pasteur 1173P2 4696897 YP_976163.1 CDS BCG_0061 NC_008769.1 62875 63204 D hypothetical protein 62875..63204 Mycobacterium bovis BCG str. Pasteur 1173P2 4695377 YP_976164.1 CDS BCG_0062 NC_008769.1 63233 63445 D remnant of a transposase 63233..63445 Mycobacterium bovis BCG str. Pasteur 1173P2 4696701 YP_976165.1 CDS bioF2 NC_008769.1 63946 66261 D 8-amino-7-oxononanoate synthase bioF2 63946..66261 Mycobacterium bovis BCG str. Pasteur 1173P2 4696691 YP_976166.1 CDS acpA NC_008769.1 66258 66521 D acyl carrier protein 66258..66521 Mycobacterium bovis BCG str. Pasteur 1173P2 4695544 YP_976167.1 CDS BCG_0065 NC_008769.1 66518 66913 D hypothetical protein 66518..66913 Mycobacterium bovis BCG str. Pasteur 1173P2 4695773 YP_976168.1 CDS fadD34 NC_008769.1 66910 68598 D fatty-acid-CoA ligase 66910..68598 Mycobacterium bovis BCG str. Pasteur 1173P2 4697408 YP_976169.1 CDS BCG_0067c NC_008769.1 68799 69479 R Differs from Mb0037c and Rv0036c by 1aa, L186P, and at C-terminal end due to frameshift resulting from 1 bp deletion at position equivalent to Mycobacterium tuberculosis H37Rv2, 39228-39228, after codon 202; hypothetical protein complement(68799..69479) Mycobacterium bovis BCG str. Pasteur 1173P2 4699133 YP_976170.1 CDS BCG_0068c NC_008769.1 69527 70852 R integral membrane protein complement(69527..70852) Mycobacterium bovis BCG str. Pasteur 1173P2 4697953 YP_976171.1 CDS BCG_0069 NC_008769.1 70954 71562 D hypothetical protein 70954..71562 Mycobacterium bovis BCG str. Pasteur 1173P2 4696034 YP_976172.1 CDS BCG_0070c NC_008769.1 71654 72001 R Differs from Rv0039c by 1aa, F24C; hypothetical protein complement(71654..72001) Mycobacterium bovis BCG str. Pasteur 1173P2 4699368 YP_976173.1 CDS mtc28 NC_008769.1 72083 73015 R hypothetical protein complement(72083..73015) Mycobacterium bovis BCG str. Pasteur 1173P2 4697254 YP_976174.1 CDS leuS NC_008769.1 73212 76121 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 73212..76121 Mycobacterium bovis BCG str. Pasteur 1173P2 4697737 YP_976175.1 CDS BCG_0073c NC_008769.1 76231 76857 R transcriptional regulatory protein (marR-family) complement(76231..76857) Mycobacterium bovis BCG str. Pasteur 1173P2 4697485 YP_976176.1 CDS BCG_0074c NC_008769.1 77016 77750 R GntR family transcriptional regulator complement(77016..77750) Mycobacterium bovis BCG str. Pasteur 1173P2 4695352 YP_976177.1 CDS BCG_0075c NC_008769.1 77883 78677 R oxidoreductase complement(77883..78677) Mycobacterium bovis BCG str. Pasteur 1173P2 4697694 YP_976178.1 CDS BCG_0076c NC_008769.1 78693 79589 R hydrolase complement(78693..79589) Mycobacterium bovis BCG str. Pasteur 1173P2 4697521 YP_976179.1 CDS ino1 NC_008769.1 79671 80774 R Differs from Mb0047c by 1aa, T120I, and from Rv0046c by 2aa, T120I, G190R; myo-inositol-1-phosphate synthase INO1 complement(79671..80774) Mycobacterium bovis BCG str. Pasteur 1173P2 4696669 YP_976180.1 CDS BCG_0078c NC_008769.1 80835 81377 R hypothetical protein complement(80835..81377) Mycobacterium bovis BCG str. Pasteur 1173P2 4697433 YP_976181.1 CDS BCG_0079c NC_008769.1 81478 82347 R Differs from Rv0048c by 1aa, A250V; hypothetical protein complement(81478..82347) Mycobacterium bovis BCG str. Pasteur 1173P2 4698581 YP_976182.1 CDS BCG_0080 NC_008769.1 82481 82894 D hypothetical protein 82481..82894 Mycobacterium bovis BCG str. Pasteur 1173P2 4696521 YP_976183.1 CDS ponA1 NC_008769.1 83313 85358 D In Mycobacterium bovis BCG Pasteur, insertion of 3 codons after position 632 leads to a slightly longer product compared to its homologs in Mycobacterium tuberculosis strain H37Rv (681 aa versus 678 aa) and Mycobacterium bovis AF2122/97 (681 aa versus 680 aa). In addition, differs from Rv0050 by 1aa, L6P; bifunctional penicillin-binding protein 1A/1B PONA1 83313..85358 Mycobacterium bovis BCG str. Pasteur 1173P2 4696779 YP_976184.1 CDS BCG_0082 NC_008769.1 85355 87037 D hypothetical protein 85355..87037 Mycobacterium bovis BCG str. Pasteur 1173P2 4696279 YP_976185.1 CDS BCG_0083 NC_008769.1 87069 87632 D hypothetical protein 87069..87632 Mycobacterium bovis BCG str. Pasteur 1173P2 4697704 YP_976186.1 CDS rpsF NC_008769.1 87851 88141 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 87851..88141 Mycobacterium bovis BCG str. Pasteur 1173P2 4695848 YP_976187.1 CDS ssb NC_008769.1 88245 88739 D binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 88245..88739 Mycobacterium bovis BCG str. Pasteur 1173P2 4697300 YP_976188.1 CDS rpsR NC_008769.1 88781 89035 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 88781..89035 Mycobacterium bovis BCG str. Pasteur 1173P2 4695625 YP_976189.1 CDS rplI NC_008769.1 89068 89526 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 89068..89526 Mycobacterium bovis BCG str. Pasteur 1173P2 4695807 YP_976190.1 CDS BCG_0088 NC_008769.1 89555 90076 D hypothetical protein 89555..90076 Mycobacterium bovis BCG str. Pasteur 1173P2 4695924 YP_976191.1 CDS dnaB NC_008769.1 90055 92679 D unwinds double stranded DNA; these Mycobacterial enzymes appear to contain inteins; replicative DNA helicase 90055..92679 Mycobacterium bovis BCG str. Pasteur 1173P2 4696243 YP_976192.1 CDS BCG_0090 NC_008769.1 92859 93551 D hypothetical protein 92859..93551 Mycobacterium bovis BCG str. Pasteur 1173P2 4697423 YP_976193.1 CDS BCG_0091 NC_008769.1 93568 94626 D hypothetical protein 93568..94626 Mycobacterium bovis BCG str. Pasteur 1173P2 4697073 YP_976194.1 CDS BCG_0092 NC_008769.1 94650 95075 D hypothetical protein 94650..95075 Mycobacterium bovis BCG str. Pasteur 1173P2 4697355 YP_976195.1 CDS celA1 NC_008769.1 95211 96353 D Differs from Mb0063 by 1aa, A72D, and from Rv0062 by 2aa, A72D, V106I; cellulase celA1 (endoglucanase) 95211..96353 Mycobacterium bovis BCG str. Pasteur 1173P2 4696098 YP_976196.1 CDS BCG_0094 NC_008769.1 96582 98021 D oxidoreductase 96582..98021 Mycobacterium bovis BCG str. Pasteur 1173P2 4697596 YP_976197.1 CDS BCG_0095 NC_008769.1 98279 101218 D Differs from Mb0065 by 1aa, T435I, and from Rv0064 by 4aa, T435I, D457G, F550V, P906R; hypothetical protein 98279..101218 Mycobacterium bovis BCG str. Pasteur 1173P2 4696895 YP_976198.1 CDS BCG_0095A NC_008769.1 101285 101524 D Differs from Rv0064A by 1aa,V48A; antitoxin 101285..101524 Mycobacterium bovis BCG str. Pasteur 1173P2 4697388 YP_976199.1 CDS BCG_0096 NC_008769.1 101517 101918 D hypothetical protein 101517..101918 Mycobacterium bovis BCG str. Pasteur 1173P2 4697383 YP_976200.1 CDS icd2 NC_008769.1 101970 104207 R Differs from Rv0066c by 1aa, N117K; isocitrate dehydrogenase complement(101970..104207) Mycobacterium bovis BCG str. Pasteur 1173P2 4695423 YP_976201.1 CDS BCG_0098c NC_008769.1 104325 104894 R TetR family transcriptional regulator complement(104325..104894) Mycobacterium bovis BCG str. Pasteur 1173P2 4699214 YP_976202.1 CDS BCG_0099 NC_008769.1 104997 105908 D Differs from Rv0068 by 1aa, L214V; short chain dehydrogenase 104997..105908 Mycobacterium bovis BCG str. Pasteur 1173P2 4697775 YP_976203.1 CDS sdaA NC_008769.1 105933 107318 R l-serine dehydratase sdaA complement(105933..107318) Mycobacterium bovis BCG str. Pasteur 1173P2 4696487 YP_976204.1 CDS glyA NC_008769.1 107315 108592 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(107315..108592) Mycobacterium bovis BCG str. Pasteur 1173P2 4697898 YP_976205.1 CDS BCG_0102 NC_008769.1 109182 109934 D In Mycobacterium bovis BCG Pasteur, a 45 bp insertion (5 copies of VDP repeat) leads to longer products compared to its homologs in Mycobacterium tuberculosis strain H37Rv (250 aa versus 235 aa) and Mycobacterium bovis (250 aa versus 238 aa); maturase 109182..109934 Mycobacterium bovis BCG str. Pasteur 1173P2 4697847 YP_976206.1 CDS BCG_0103 NC_008769.1 110365 111414 D glutamine ABC transporter 110365..111414 Mycobacterium bovis BCG str. Pasteur 1173P2 4697457 YP_976207.1 CDS BCG_0104 NC_008769.1 111417 112409 D In Mycobacterium tuberculosis strain H37Rv, Rv0073 exists as a single gene as in Mycobacterium bovis BCG Pasteur. In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits Rv0073 into 2 parts, Mb0074 and Mb0075; glutamine ABC transporter ATP-binding protein 111417..112409 Mycobacterium bovis BCG str. Pasteur 1173P2 4695394 YP_976208.1 CDS BCG_0105 NC_008769.1 112489 113724 D hypothetical protein 112489..113724 Mycobacterium bovis BCG str. Pasteur 1173P2 4698175 YP_976209.1 CDS BCG_0106 NC_008769.1 113737 114909 D Differs from Rv0075 and Mb0077 by 1aa, G326D; aminotransferase 113737..114909 Mycobacterium bovis BCG str. Pasteur 1173P2 4696342 YP_976210.1 CDS BCG_0107c NC_008769.1 114924 115313 R hypothetical protein complement(114924..115313) Mycobacterium bovis BCG str. Pasteur 1173P2 4696055 YP_976211.1 CDS BCG_0108c NC_008769.1 115377 116207 R oxidoreductase complement(115377..116207) Mycobacterium bovis BCG str. Pasteur 1173P2 4695393 YP_976212.1 CDS BCG_0109 NC_008769.1 116269 116874 D Differs from Rv0078 by 1aa, V113I; transcriptional regulatory protein 116269..116874 Mycobacterium bovis BCG str. Pasteur 1173P2 4698145 YP_976213.1 CDS BCG_0110c NC_008769.1 116949 117542 R hypothetical protein complement(116949..117542) Mycobacterium bovis BCG str. Pasteur 1173P2 4696050 YP_976214.1 CDS BCG_0111c NC_008769.1 117539 117751 R hypothetical protein complement(117539..117751) Mycobacterium bovis BCG str. Pasteur 1173P2 4697451 YP_976215.1 CDS BCG_0112 NC_008769.1 117945 118766 D hypothetical protein 117945..118766 Mycobacterium bovis BCG str. Pasteur 1173P2 4697996 YP_976216.1 CDS BCG_0113 NC_008769.1 118763 119221 D Differs from Mb0083 by 1aa, C35R, and from Rv0080 by 2aa, C35R, V60G; hypothetical protein 118763..119221 Mycobacterium bovis BCG str. Pasteur 1173P2 4695860 YP_976217.1 CDS BCG_0114 NC_008769.1 119316 119660 D transcriptional regulatory protein 119316..119660 Mycobacterium bovis BCG str. Pasteur 1173P2 4698066 YP_976218.1 CDS BCG_0115 NC_008769.1 119665 120144 D Differs from Rv0082 by 1aa, R74Q; oxidoreductase 119665..120144 Mycobacterium bovis BCG str. Pasteur 1173P2 4695863 YP_976219.1 CDS BCG_0116 NC_008769.1 120141 122069 D In Mycobacterium bovis, a single base transversion (a-t) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (642 aa versus 640 aa). Differs from Mb0086 by 1aa, A177V; oxidoreductase 120141..122069 Mycobacterium bovis BCG str. Pasteur 1173P2 4697023 YP_976220.1 CDS hycD NC_008769.1 122069 123019 D formate hydrogenlyase hycD (FHL) 122069..123019 Mycobacterium bovis BCG str. Pasteur 1173P2 4695375 YP_976221.1 CDS hycP NC_008769.1 123030 123692 D hydrogenase hycP 123030..123692 Mycobacterium bovis BCG str. Pasteur 1173P2 4697265 YP_976222.1 CDS hycQ NC_008769.1 123692 125158 D Differs from Rv0086 by 1aa, T118M; hydrogenase hycQ 123692..125158 Mycobacterium bovis BCG str. Pasteur 1173P2 4697267 YP_976223.1 CDS hycE NC_008769.1 125155 126633 D Differs from Rv0087 by 1aa, I230V; formate hydrogenase hycQ (FHL) 125155..126633 Mycobacterium bovis BCG str. Pasteur 1173P2 4697268 YP_976224.1 CDS BCG_0121 NC_008769.1 126668 127342 D hypothetical protein 126668..127342 Mycobacterium bovis BCG str. Pasteur 1173P2 4697266 YP_976225.1 CDS BCG_0122 NC_008769.1 127499 128092 D methyltransferase/methylase 127499..128092 Mycobacterium bovis BCG str. Pasteur 1173P2 4695770 YP_976226.1 CDS BCG_0123 NC_008769.1 128221 128991 D hypothetical protein 128221..128991 Mycobacterium bovis BCG str. Pasteur 1173P2 4695984 YP_976227.1 CDS mtn NC_008769.1 129425 130192 D bifunctional MTA/SAH nucleosidase mtn 129425..130192 Mycobacterium bovis BCG str. Pasteur 1173P2 4697519 YP_976228.1 CDS ctpA NC_008769.1 130324 132609 D Differs from Rv0092 by 1aa, A3T; cation transporter p-type atpase A ctpA 130324..132609 Mycobacterium bovis BCG str. Pasteur 1173P2 4697738 YP_976229.1 CDS BCG_0126c NC_008769.1 132556 133404 R Differs from Rv0093c by 1aa, R22C; hypothetical protein complement(132556..133404) Mycobacterium bovis BCG str. Pasteur 1173P2 4697724 YP_976230.1 CDS BCG_0127c NC_008769.1 133451 134404 R Differs from Rv0094c by 3aa, D256E, W296R, K315E; hypothetical protein complement(133451..134404) Mycobacterium bovis BCG str. Pasteur 1173P2 4696049 YP_976231.1 CDS BCG_0128c NC_008769.1 134175 134957 R In Mycobacterium tuberculosis strain H37Rv, Rv0095c and Rv1588 exist as separate genes in their respective positions. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 73 bp substitution leads to a single combined gene. Differs from Rv0095c by 5aa, E57D, T70S, V85A, V91G, A92Q; hypothetical protein complement(134175..134957) Mycobacterium bovis BCG str. Pasteur 1173P2 4698785 YP_976232.1 CDS PPE1 NC_008769.1 135066 136457 D Differs from Rv0096 by 1aa, W182R; PPE family protein 135066..136457 Mycobacterium bovis BCG str. Pasteur 1173P2 4697111 YP_976233.1 CDS BCG_0130 NC_008769.1 136476 137345 D oxidoreductase 136476..137345 Mycobacterium bovis BCG str. Pasteur 1173P2 4696160 YP_976234.1 CDS BCG_0131 NC_008769.1 137342 137893 D hypothetical protein 137342..137893 Mycobacterium bovis BCG str. Pasteur 1173P2 4697693 YP_976235.1 CDS fadD10 NC_008769.1 137898 139520 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 137898..139520 Mycobacterium bovis BCG str. Pasteur 1173P2 4697870 YP_976236.1 CDS BCG_0133 NC_008769.1 139525 139761 D hypothetical protein 139525..139761 Mycobacterium bovis BCG str. Pasteur 1173P2 4695648 YP_976237.1 CDS nrp NC_008769.1 139743 147281 D peptide synthetase nrp 139743..147281 Mycobacterium bovis BCG str. Pasteur 1173P2 4696972 YP_976238.1 CDS BCG_0135 NC_008769.1 147456 149441 D integral membrane protein 147456..149441 Mycobacterium bovis BCG str. Pasteur 1173P2 4699183 YP_976239.1 CDS ctpB NC_008769.1 149657 151915 R Differs from Rv0103c by 1aa, S22L; cation-transporter P-type atpase B ctpB complement(149657..151915) Mycobacterium bovis BCG str. Pasteur 1173P2 4697602 YP_976240.1 CDS BCG_0137 NC_008769.1 152059 153573 D hypothetical protein 152059..153573 Mycobacterium bovis BCG str. Pasteur 1173P2 4697687 YP_976241.1 CDS rpmB NC_008769.1 153722 154006 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(153722..154006) Mycobacterium bovis BCG str. Pasteur 1173P2 4695457 YP_976242.1 CDS BCG_0139 NC_008769.1 154116 155312 D hypothetical protein 154116..155312 Mycobacterium bovis BCG str. Pasteur 1173P2 4697629 YP_976243.1 CDS ctpI NC_008769.1 155407 160284 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-t) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; differs from Rv0107c by 3aa, V136A, P1247S, S1327A; cation-transporter atpase I ctpI complement(155407..160284) Mycobacterium bovis BCG str. Pasteur 1173P2 4696800 YP_976244.1 CDS BCG_0141c NC_008769.1 160638 160847 R hypothetical protein complement(160638..160847) Mycobacterium bovis BCG str. Pasteur 1173P2 4697539 YP_976245.1 CDS PE_PGRS1 NC_008769.1 161126 162616 D Differs from Rv0109 by 1aa, G346R; PE-PGRS family protein 161126..162616 Mycobacterium bovis BCG str. Pasteur 1173P2 4698119 YP_976246.1 CDS BCG_0143 NC_008769.1 162764 163513 D integral membrane protein 162764..163513 Mycobacterium bovis BCG str. Pasteur 1173P2 4696296 YP_976247.1 CDS BCG_0144 NC_008769.1 163694 165751 D acyltransferase 163694..165751 Mycobacterium bovis BCG str. Pasteur 1173P2 4697514 YP_976248.1 CDS gca NC_008769.1 166033 166989 D GDP-mannose 4,6-dehydratase 166033..166989 Mycobacterium bovis BCG str. Pasteur 1173P2 4696313 YP_976249.1 CDS gmhA NC_008769.1 167063 167653 D catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 167063..167653 Mycobacterium bovis BCG str. Pasteur 1173P2 4696528 YP_976250.1 CDS BCG_0147 NC_008769.1 167685 168257 D Differs from Rv0114 by 1aa, R121G; dehydratase 167685..168257 Mycobacterium bovis BCG str. Pasteur 1173P2 4697849 YP_976251.1 CDS BCG_0149 NC_008769.1 168257 169324 D In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-c) equivalent to Mycobacterium tuberculosis H37Rv position 139559, leads to shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. In addition, in Mycobacterium bovis, a single base insertion, at position equivalent to 138823, leads to a different NH2 part; sugar kinase 168257..169324 Mycobacterium bovis BCG str. Pasteur 1173P2 4697418 YP_976252.1 CDS BCG_0150c NC_008769.1 170012 170767 R hypothetical protein complement(170012..170767) Mycobacterium bovis BCG str. Pasteur 1173P2 4695709 YP_976253.1 CDS oxyS NC_008769.1 170945 171889 D oxidative stress response regulatory protein oxyS 170945..171889 Mycobacterium bovis BCG str. Pasteur 1173P2 4697654 YP_976254.1 CDS oxcA NC_008769.1 171873 173621 R catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase complement(171873..173621) Mycobacterium bovis BCG str. Pasteur 1173P2 4695405 YP_976255.1 CDS fadD7 NC_008769.1 173794 175371 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 173794..175371 Mycobacterium bovis BCG str. Pasteur 1173P2 4695404 YP_976256.1 CDS fusA2b NC_008769.1 175372 177516 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(175372..177516) Mycobacterium bovis BCG str. Pasteur 1173P2 4696274 YP_976257.1 CDS BCG_0155c NC_008769.1 177652 178086 R hypothetical protein complement(177652..178086) Mycobacterium bovis BCG str. Pasteur 1173P2 4695507 YP_976258.1 CDS BCG_0156 NC_008769.1 178235 178603 D hypothetical protein 178235..178603 Mycobacterium bovis BCG str. Pasteur 1173P2 4696264 YP_976259.1 CDS BCG_0157 NC_008769.1 178600 178968 D hypothetical protein 178600..178968 Mycobacterium bovis BCG str. Pasteur 1173P2 4695590 YP_976260.1 CDS PE_PGRS2 NC_008769.1 179277 180893 D In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 180 bp insertion leads to a longer product in the 3' direction compared to its homolog in Mycobacterium tuberculosis strain H37Rv (538 aa versus 487 aa); PE-PGRS family protein 179277..180893 Mycobacterium bovis BCG str. Pasteur 1173P2 4695953 YP_976261.1 CDS pepA NC_008769.1 181045 182112 D serine protease pepA 181045..182112 Mycobacterium bovis BCG str. Pasteur 1173P2 4697722 YP_976262.1 CDS treS NC_008769.1 182221 184026 D trehalose synthase treS 182221..184026 Mycobacterium bovis BCG str. Pasteur 1173P2 4696118 YP_976263.1 CDS BCG_0161 NC_008769.1 184129 185496 D Differs from Rv0127 by 1aa, P18S; hypothetical protein 184129..185496 Mycobacterium bovis BCG str. Pasteur 1173P2 4696821 YP_976264.1 CDS BCG_0162 NC_008769.1 185564 186343 D hypothetical protein 185564..186343 Mycobacterium bovis BCG str. Pasteur 1173P2 4697426 YP_976265.1 CDS fbpC NC_008769.1 186475 187497 R hypothetical protein complement(186475..187497) Mycobacterium bovis BCG str. Pasteur 1173P2 4697184 YP_976266.1 CDS BCG_0164 NC_008769.1 187744 188199 D hypothetical protein 187744..188199 Mycobacterium bovis BCG str. Pasteur 1173P2 4696522 YP_976267.1 CDS fadE1 NC_008769.1 188212 189555 R acyl-CoA dehydrogenase fadE1 complement(188212..189555) Mycobacterium bovis BCG str. Pasteur 1173P2 4695959 YP_976268.1 CDS fgd2 NC_008769.1 189597 190679 R Differs from Rv0132c by 1aa, E147K; F420-dependent glucose-6-phosphate dehydrogenase complement(189597..190679) Mycobacterium bovis BCG str. Pasteur 1173P2 4695872 YP_976269.1 CDS BCG_0167 NC_008769.1 190766 191248 D In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis AF2122/97, codon 161 is TAC and in Mycobacterium bovis BCG Pasteur, TAA; acetyltransferase 190766..191248 Mycobacterium bovis BCG str. Pasteur 1173P2 4695794 YP_976270.1 CDS BCG_0171c NC_008769.1 192541 193146 R transcriptional regulatory protein complement(192541..193146) Mycobacterium bovis BCG str. Pasteur 1173P2 4696778 YP_976271.1 CDS cyp138 NC_008769.1 193263 194588 D cytochrome p450 138 cyp138 193263..194588 Mycobacterium bovis BCG str. Pasteur 1173P2 4696345 YP_976272.1 CDS msrA NC_008769.1 194609 195157 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A complement(194609..195157) Mycobacterium bovis BCG str. Pasteur 1173P2 4696607 YP_976273.1 CDS BCG_0174 NC_008769.1 195220 195723 D Differs from Mb0143 by 1aa, D96G; hypothetical protein 195220..195723 Mycobacterium bovis BCG str. Pasteur 1173P2 4697736 YP_976274.1 CDS BCG_0175 NC_008769.1 195724 196746 D Differs from Rv0139 by 1aa, R227H; oxidoreductase 195724..196746 Mycobacterium bovis BCG str. Pasteur 1173P2 4697886 YP_976275.1 CDS BCG_0176 NC_008769.1 196807 197187 D hypothetical protein 196807..197187 Mycobacterium bovis BCG str. Pasteur 1173P2 4696471 YP_976276.1 CDS BCG_0177c NC_008769.1 197168 197578 R hypothetical protein complement(197168..197578) Mycobacterium bovis BCG str. Pasteur 1173P2 4697244 YP_976277.1 CDS BCG_0178 NC_008769.1 197608 198534 D hypothetical protein 197608..198534 Mycobacterium bovis BCG str. Pasteur 1173P2 4695477 YP_976278.1 CDS BCG_0179c NC_008769.1 198601 200079 R Differs from Rv0143c by 1aa, L34F; hypothetical protein complement(198601..200079) Mycobacterium bovis BCG str. Pasteur 1173P2 4696266 YP_976279.1 CDS BCG_0180 NC_008769.1 200181 201023 D TetR family transcriptional regulator 200181..201023 Mycobacterium bovis BCG str. Pasteur 1173P2 4697048 YP_976280.1 CDS BCG_0181 NC_008769.1 201112 202065 D hypothetical protein 201112..202065 Mycobacterium bovis BCG str. Pasteur 1173P2 4696148 YP_976281.1 CDS BCG_0182 NC_008769.1 202108 203040 D hypothetical protein 202108..203040 Mycobacterium bovis BCG str. Pasteur 1173P2 4695365 YP_976282.1 CDS BCG_0183 NC_008769.1 203135 204655 D aldehyde dehydrogenase 203135..204655 Mycobacterium bovis BCG str. Pasteur 1173P2 4695675 YP_976283.1 CDS BCG_0184 NC_008769.1 204730 205590 D short-chain type dehydrogenase/reductase 204730..205590 Mycobacterium bovis BCG str. Pasteur 1173P2 4697099 YP_976284.1 CDS BCG_0185 NC_008769.1 205597 206565 D quinone oxidoreductase 205597..206565 Mycobacterium bovis BCG str. Pasteur 1173P2 4698796 YP_976285.1 CDS BCG_0186c NC_008769.1 206562 206849 R hypothetical protein complement(206562..206849) Mycobacterium bovis BCG str. Pasteur 1173P2 4697427 YP_976286.1 CDS PE1 NC_008769.1 207440 209206 R Differs from Rv0151c by 1aa, R26G; PE family protein complement(207440..209206) Mycobacterium bovis BCG str. Pasteur 1173P2 4697778 YP_976287.1 CDS PE2 NC_008769.1 209216 210793 R PE family protein complement(209216..210793) Mycobacterium bovis BCG str. Pasteur 1173P2 4695743 YP_976288.1 CDS ptbB NC_008769.1 211052 211882 R Differs from Rv0153c by 1aa, G105D; phosphotyrosine protein phosphatase ptpB complement(211052..211882) Mycobacterium bovis BCG str. Pasteur 1173P2 4699376 YP_976289.1 CDS fadE2 NC_008769.1 211884 213095 R acyl-CoA dehydrogenase fadE2 complement(211884..213095) Mycobacterium bovis BCG str. Pasteur 1173P2 4697316 YP_976290.1 CDS pntAa NC_008769.1 213519 214619 D NAD(p) transhydrogenase (subunit alpha) pntAa 213519..214619 Mycobacterium bovis BCG str. Pasteur 1173P2 4699118 YP_976291.1 CDS pntAb NC_008769.1 214620 214952 D Differs from Rv0156 by 1aa, C2Y; NAD(p) transhydrogenase (subunit alpha) pntAb 214620..214952 Mycobacterium bovis BCG str. Pasteur 1173P2 4696817 YP_976292.1 CDS pntB NC_008769.1 214949 216376 D NAD(p) transhydrogenase (subunit beta) pntB 214949..216376 Mycobacterium bovis BCG str. Pasteur 1173P2 4696818 YP_976293.1 CDS BCG_0194 NC_008769.1 216682 217326 D TetR family transcriptional regulator 216682..217326 Mycobacterium bovis BCG str. Pasteur 1173P2 4696277 YP_976294.1 CDS PE3 NC_008769.1 217330 218736 R Differs from Rv0159c by 1aa, T255P; PE family protein complement(217330..218736) Mycobacterium bovis BCG str. Pasteur 1173P2 4696051 YP_976295.1 CDS PE4 NC_008769.1 218828 220336 R Differs from Rv0160c by 2aa, T116A, T211A; PE family protein complement(218828..220336) Mycobacterium bovis BCG str. Pasteur 1173P2 4698937 YP_976296.1 CDS BCG_0197 NC_008769.1 220504 221853 D oxidoreductase 220504..221853 Mycobacterium bovis BCG str. Pasteur 1173P2 4696201 YP_976297.1 CDS adhE1 NC_008769.1 221881 223032 R Differs from Rv0162c and Mb0167c by 1aa, R41H; zinc-type alcohol dehydrogenase (e subunit) adhE complement(221881..223032) Mycobacterium bovis BCG str. Pasteur 1173P2 4698436 YP_976298.1 CDS BCG_0199 NC_008769.1 223014 223469 D hypothetical protein 223014..223469 Mycobacterium bovis BCG str. Pasteur 1173P2 4697252 YP_976299.1 CDS TB18.5 NC_008769.1 223523 224008 D hypothetical protein 223523..224008 Mycobacterium bovis BCG str. Pasteur 1173P2 4697507 YP_976300.1 CDS BCG_0201c NC_008769.1 224022 224837 R In Mycobacterium tuberculosis strain H37Rv, Rv0165c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a 2 bp insertion (*-cc) leads to a product with a different COOH terminus; GntR family transcriptional regulator complement(224022..224837) Mycobacterium bovis BCG str. Pasteur 1173P2 4697561 YP_976301.1 CDS fadD5 NC_008769.1 224892 226556 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 224892..226556 Mycobacterium bovis BCG str. Pasteur 1173P2 4697652 YP_976302.1 CDS yrbE1A NC_008769.1 226760 227557 D integral membrane protein YrbE1a 226760..227557 Mycobacterium bovis BCG str. Pasteur 1173P2 4696272 YP_976303.1 CDS yrbE1B NC_008769.1 227559 228428 D integral membrane protein YrbE1b 227559..228428 Mycobacterium bovis BCG str. Pasteur 1173P2 4697801 YP_976304.1 CDS mce1A NC_008769.1 228433 229797 D Differs from Rv0169 by 2aa, A313S, S359P; Differs from Rv0169 by 2aa, A313S, S359P; MCE-family protein mce1A 228433..229797 Mycobacterium bovis BCG str. Pasteur 1173P2 4697802 YP_976305.1 CDS mce1B NC_008769.1 229794 230834 D Differs from Rv0170 by 1aa, T179I; MCE-family protein mce1B 229794..230834 Mycobacterium bovis BCG str. Pasteur 1173P2 4695351 YP_976306.1 CDS mce1C NC_008769.1 230831 232378 D Differs from Rv0171 by 1aa, D212E; MCE-family protein mce1C 230831..232378 Mycobacterium bovis BCG str. Pasteur 1173P2 4697196 YP_976307.1 CDS mce1D NC_008769.1 232375 233967 D MCE-family protein mce1D 232375..233967 Mycobacterium bovis BCG str. Pasteur 1173P2 4697197 YP_976308.1 CDS lprK NC_008769.1 233964 235136 D mce family lipoprotein LprK 233964..235136 Mycobacterium bovis BCG str. Pasteur 1173P2 4697198 YP_976309.1 CDS mce1F NC_008769.1 235130 236677 D Differs from Rv0174 by 1aa, P370L; MCE-family protein mce1F 235130..236677 Mycobacterium bovis BCG str. Pasteur 1173P2 4698588 YP_976310.1 CDS BCG_0212 NC_008769.1 236713 237354 D mce associated membrane protein 236713..237354 Mycobacterium bovis BCG str. Pasteur 1173P2 4697199 YP_976311.1 CDS BCG_0213 NC_008769.1 237351 238319 D Differs from Mb0182 by 1aa, S285N, and from Rv0176 by 3aa, S285N, S290Q, A291S; mce associated transmembrane protein 237351..238319 Mycobacterium bovis BCG str. Pasteur 1173P2 4697872 YP_976312.1 CDS BCG_0214 NC_008769.1 238316 238870 D mce associated protein 238316..238870 Mycobacterium bovis BCG str. Pasteur 1173P2 4697011 YP_976313.1 CDS BCG_0215 NC_008769.1 238837 239571 D MCE associated membrane protein 238837..239571 Mycobacterium bovis BCG str. Pasteur 1173P2 4696892 YP_976314.1 CDS lprO NC_008769.1 239602 240711 R Differs from Rv0179c by 1aa, H124R; lipoprotein lprO complement(239602..240711) Mycobacterium bovis BCG str. Pasteur 1173P2 4696358 YP_976315.1 CDS BCG_0217c NC_008769.1 240791 242149 R hypothetical protein complement(240791..242149) Mycobacterium bovis BCG str. Pasteur 1173P2 4698591 YP_976316.1 CDS BCG_0218c NC_008769.1 242176 242910 R hypothetical protein complement(242176..242910) Mycobacterium bovis BCG str. Pasteur 1173P2 4697013 YP_976317.1 CDS sigG NC_008769.1 242927 244039 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; RNA polymerase factor sigma-70 complement(242927..244039) Mycobacterium bovis BCG str. Pasteur 1173P2 4695936 YP_976318.1 CDS BCG_0220 NC_008769.1 243987 244826 D lysophospholipase 243987..244826 Mycobacterium bovis BCG str. Pasteur 1173P2 4695354 YP_976319.1 CDS BCG_0221 NC_008769.1 244868 245617 D hypothetical protein 244868..245617 Mycobacterium bovis BCG str. Pasteur 1173P2 4697419 YP_976320.1 CDS BCG_0222 NC_008769.1 245614 246123 D hypothetical protein 245614..246123 Mycobacterium bovis BCG str. Pasteur 1173P2 4695540 YP_976321.1 CDS bglS NC_008769.1 246168 248243 D Differs from Mb0192 by 1aa, S504I, and from Rv0186 by 2aa, S504I, R532P; beta-glucosidase bglS 246168..248243 Mycobacterium bovis BCG str. Pasteur 1173P2 4697390 YP_976322.1 CDS BCG_0224 NC_008769.1 248604 249266 D Differs from Rv0187 and Mb0193 by 1aa, V147A; o-methyltransferase 248604..249266 Mycobacterium bovis BCG str. Pasteur 1173P2 4696688 YP_976323.1 CDS BCG_0225 NC_008769.1 249385 249816 D hypothetical protein 249385..249816 Mycobacterium bovis BCG str. Pasteur 1173P2 4697406 YP_976324.1 CDS ilvD NC_008769.1 249895 251622 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(249895..251622) Mycobacterium bovis BCG str. Pasteur 1173P2 4697026 YP_976325.1 CDS BCG_0227 NC_008769.1 251770 252060 D hypothetical protein 251770..252060 Mycobacterium bovis BCG str. Pasteur 1173P2 4699341 YP_976326.1 CDS BCG_0228 NC_008769.1 252188 253429 D integral membrane protein 252188..253429 Mycobacterium bovis BCG str. Pasteur 1173P2 4696104 YP_976327.1 CDS BCG_0229 NC_008769.1 253506 254564 D In Mycobacterium tuberculosis strain H37Rv, Rv0192 and Rv0192A exist as 2 genes with an overlap region. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-g) leads to a single product. Differs from Mb0198 by 1aa, A279V and from Rv0192 by 2aa, P113S, A279V; hypothetical protein 253506..254564 Mycobacterium bovis BCG str. Pasteur 1173P2 4698256 YP_976328.1 CDS BCG_0230c NC_008769.1 254624 256471 R Differs from Rv0193c and Mb0199c by 1aa, E417K; hypothetical protein complement(254624..256471) Mycobacterium bovis BCG str. Pasteur 1173P2 4698698 YP_976329.1 CDS BCG_0231 NC_008769.1 256778 260362 D Differs from Mb0200 by 1aa, I49V, and from Rv0194 by 2aa, T74M, M223T; drugs-transport transmembrane ATP-binding protein ABC transporter 256778..260362 Mycobacterium bovis BCG str. Pasteur 1173P2 4698450 YP_976330.1 CDS BCG_0232 NC_008769.1 260800 261435 D LuxR family two component transcriptional regulator 260800..261435 Mycobacterium bovis BCG str. Pasteur 1173P2 4695751 YP_976331.1 CDS BCG_0233 NC_008769.1 261548 262132 D transcriptional regulatory protein 261548..262132 Mycobacterium bovis BCG str. Pasteur 1173P2 4695509 YP_976332.1 CDS BCG_0234 NC_008769.1 262132 264378 D In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transversion (t-g) introduces a stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (748 aa versus 762 aa). Differs from Rv0197 by 1aa, S378R; oxidoreductase 262132..264378 Mycobacterium bovis BCG str. Pasteur 1173P2 4695763 YP_976333.1 CDS BCG_0235c NC_008769.1 264419 266410 R zinc metalloprotease complement(264419..266410) Mycobacterium bovis BCG str. Pasteur 1173P2 4696246 YP_976334.1 CDS BCG_0236 NC_008769.1 266453 267112 D hypothetical protein 266453..267112 Mycobacterium bovis BCG str. Pasteur 1173P2 4696352 YP_976335.1 CDS BCG_0237 NC_008769.1 267109 267798 D hypothetical protein 267109..267798 Mycobacterium bovis BCG str. Pasteur 1173P2 4696349 YP_976336.1 CDS BCG_0238c NC_008769.1 267795 268298 R hypothetical protein complement(267795..268298) Mycobacterium bovis BCG str. Pasteur 1173P2 4696741 YP_976337.1 CDS mmpL11 NC_008769.1 268295 271195 R transmembrane transport protein mmpL11 complement(268295..271195) Mycobacterium bovis BCG str. Pasteur 1173P2 4696794 YP_976338.1 CDS BCG_0240 NC_008769.1 271417 271827 D Differs from Rv0203 and Mb0209 by 1aa, T88K; hypothetical protein 271417..271827 Mycobacterium bovis BCG str. Pasteur 1173P2 4697541 YP_976339.1 CDS BCG_0241c NC_008769.1 271879 273162 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, the presence of a more likely start codon leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (427 a versus 412 aa). Differs from Rv0204c by 1aa, L321V; hypothetical protein complement(271879..273162) Mycobacterium bovis BCG str. Pasteur 1173P2 4696793 YP_976340.1 CDS BCG_0242 NC_008769.1 273287 274390 D Differs from Rv0205 by 1aa, R72H; hypothetical protein 273287..274390 Mycobacterium bovis BCG str. Pasteur 1173P2 4697022 YP_976341.1 CDS mmpL3 NC_008769.1 274387 277221 R Differs from Rv0206c by 2aa, I384F, E466D; transmembrane transport protein mmpL3 complement(274387..277221) Mycobacterium bovis BCG str. Pasteur 1173P2 4697222 YP_976342.1 CDS BCG_0244c NC_008769.1 277287 278015 R hypothetical protein complement(277287..278015) Mycobacterium bovis BCG str. Pasteur 1173P2 4695521 YP_976343.1 CDS trmB NC_008769.1 278018 278809 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(278018..278809) Mycobacterium bovis BCG str. Pasteur 1173P2 4697253 YP_976344.1 CDS BCG_0246 NC_008769.1 278941 280026 D Differs from Rv0209 by 1aa, A162V; hypothetical protein 278941..280026 Mycobacterium bovis BCG str. Pasteur 1173P2 4697234 YP_976345.1 CDS BCG_0247 NC_008769.1 280023 281501 D Differs from Rv0210 by 1aa, T486A; hypothetical protein 280023..281501 Mycobacterium bovis BCG str. Pasteur 1173P2 4699331 YP_976346.1 CDS pckA NC_008769.1 281685 283505 D catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP; phosphoenolpyruvate carboxykinase 281685..283505 Mycobacterium bovis BCG str. Pasteur 1173P2 4697998 YP_976347.1 CDS nadR NC_008769.1 283572 284543 R transcriptional regulator NadR complement(283572..284543) Mycobacterium bovis BCG str. Pasteur 1173P2 4698418 YP_976348.1 CDS BCG_0250c NC_008769.1 284540 285853 R methyltransferase complement(284540..285853) Mycobacterium bovis BCG str. Pasteur 1173P2 4696616 YP_976349.1 CDS fadD4 NC_008769.1 285967 287580 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 285967..287580 Mycobacterium bovis BCG str. Pasteur 1173P2 4697727 YP_976350.1 CDS fadE3 NC_008769.1 287622 288788 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 29 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (388 aa versus 357 aa). Differs from Mb0221c by 1aa, S361A; acyl-CoA dehydrogenase fadE3 complement(287622..288788) Mycobacterium bovis BCG str. Pasteur 1173P2 4696271 YP_976351.1 CDS BCG_0253 NC_008769.1 288845 289858 D hypothetical protein 288845..289858 Mycobacterium bovis BCG str. Pasteur 1173P2 4697579 YP_976352.1 CDS lipW NC_008769.1 289855 290763 R Differs from Rv0217c by 1aa T184P; esterase lipW complement(289855..290763) Mycobacterium bovis BCG str. Pasteur 1173P2 4698090 YP_976353.1 CDS BCG_0255 NC_008769.1 290856 292184 D Differs from Rv0218 by 2aa, R316C, N413D; hypothetical protein 290856..292184 Mycobacterium bovis BCG str. Pasteur 1173P2 4695784 YP_976354.1 CDS BCG_0256 NC_008769.1 292186 292734 D hypothetical protein 292186..292734 Mycobacterium bovis BCG str. Pasteur 1173P2 4697761 YP_976355.1 CDS lipC NC_008769.1 292744 293985 D esterase lipC 292744..293985 Mycobacterium bovis BCG str. Pasteur 1173P2 4699256 YP_976356.1 CDS BCG_0258 NC_008769.1 293999 294772 D In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, RD10, a 1902 bp deletion leads to a shorter product with a different COOH part, compared to its homolog in Mycobacterium tuberculosis strain H37Rv (257 aa versus 469 aa). It also leads to the deletion of the next protein, echA1 (Rv0222); hypothetical protein 293999..294772 Mycobacterium bovis BCG str. Pasteur 1173P2 4698688 YP_976357.1 CDS BCG_0259c NC_008769.1 294638 295447 R In mycobacterium bovis strain AF2122/97 and Mycobacterium bovis BCG Pasteur, RD10, a 1902 bp deletion, compared to Mycobacterium tuberculosis H37Rv, truncates Rv0221c and Rv0223c and removes Rv0222c; In Mycobacterium bovis BCG Pasteur, a single base deletion at position equivalent to Mycobacterium tuberculosis H37Rv2 267419-267419(*-c) splits gene into two parts compared to its homologs in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis AF2122/97 (116 aa and 269 aa, versus 487 aa and 385 aa, respectively. Also has same 1 bp insertion, as Mycobacterium bovis AF2122/97, at position equivalent to Mycobacterium tuberculosis H37Rv2 base 266743. Deletion in Mycobacterium bovis and bovis BCG Pasteur of region RD10 leads to a different COOH part compared to Mycobacterium tuberculosis strain H37Rv. May be pseudogene; aldehyde dehydrogenase complement(294638..295447) Mycobacterium bovis BCG str. Pasteur 1173P2 4698049 YP_976358.1 CDS BCG_0260c NC_008769.1 295444 295794 R In Mycobacterium bovis BCG Pasteur, a single base deletion at position equivalent to Mycobacterium tuberculosis H37Rv2 267419-267419(*-c) splits gene into two parts compared to its homologs in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis AF2122/97 (116 aa and 269 aa, versus 487 aa and 385 aa, respectively. Also has same 1 bp insertion, as Mycobacterium bovis AF2122/97, at position equivalent to Mycobacterium tuberculosis H37Rv2 base 266743. May be pseudogene; aldehyde dehydrogenase complement(295444..295794) Mycobacterium bovis BCG str. Pasteur 1173P2 4698185 YP_976359.1 CDS BCG_0261c NC_008769.1 295893 296657 R Differs from Rv0224c by 1aa, L117F; methyltransferase complement(295893..296657) Mycobacterium bovis BCG str. Pasteur 1173P2 4699063 YP_976360.1 CDS BCG_0262 NC_008769.1 296693 297847 D hypothetical protein 296693..297847 Mycobacterium bovis BCG str. Pasteur 1173P2 4699029 YP_976361.1 CDS BCG_0263c NC_008769.1 297864 299594 R hypothetical protein complement(297864..299594) Mycobacterium bovis BCG str. Pasteur 1173P2 4698239 YP_976362.1 CDS BCG_0264c NC_008769.1 299604 300869 R Differs from Rv0227c by 1aa, R29S, and from Mb0232c by 1aa, S392N; hypothetical protein complement(299604..300869) Mycobacterium bovis BCG str. Pasteur 1173P2 4698794 YP_976363.1 CDS BCG_0265 NC_008769.1 301085 302308 D integral membrane acyltransferase 301085..302308 Mycobacterium bovis BCG str. Pasteur 1173P2 4698221 YP_976364.1 CDS BCG_0266c NC_008769.1 302336 303016 R hypothetical protein complement(302336..303016) Mycobacterium bovis BCG str. Pasteur 1173P2 4698790 YP_976365.1 CDS php NC_008769.1 303013 303993 R Differs from Rv0230c by 1aa, E199D; phosphotriesterase PHP complement(303013..303993) Mycobacterium bovis BCG str. Pasteur 1173P2 4695383 YP_976366.1 CDS fadE4 NC_008769.1 304088 305794 D acyl-CoA dehydrogenase fadE4 304088..305794 Mycobacterium bovis BCG str. Pasteur 1173P2 4697037 YP_976367.1 CDS BCG_0269 NC_008769.1 305929 306618 D TetR family transcriptional regulator 305929..306618 Mycobacterium bovis BCG str. Pasteur 1173P2 4696255 YP_976368.1 CDS nrdB NC_008769.1 306615 307559 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit beta 306615..307559 Mycobacterium bovis BCG str. Pasteur 1173P2 4695750 YP_976369.1 CDS gabD1 NC_008769.1 307635 309170 R NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinate-semialdehyde dehydrogenase complement(307635..309170) Mycobacterium bovis BCG str. Pasteur 1173P2 4698713 YP_976370.1 CDS BCG_0272c NC_008769.1 309196 310644 R hypothetical protein complement(309196..310644) Mycobacterium bovis BCG str. Pasteur 1173P2 4695548 YP_976371.1 CDS BCG_0273c NC_008769.1 310679 314881 R Differs from Rv0236c by 3aa, V412M, A990T, G1080S; hypothetical protein complement(310679..314881) Mycobacterium bovis BCG str. Pasteur 1173P2 4698499 YP_976372.1 CDS BCG_0274c NC_008769.1 314928 315101 R hypothetical protein complement(314928..315101) Mycobacterium bovis BCG str. Pasteur 1173P2 4698021 YP_976373.1 CDS lpqI NC_008769.1 315216 316382 D Differs from Rv0237 by 1aa, L129V; lipoprotein lpqI 315216..316382 Mycobacterium bovis BCG str. Pasteur 1173P2 4698823 YP_976374.1 CDS BCG_0276 NC_008769.1 316458 317072 D TetR family transcriptional regulator 316458..317072 Mycobacterium bovis BCG str. Pasteur 1173P2 4698156 YP_976375.1 CDS BCG_0277 NC_008769.1 317134 317367 D hypothetical protein 317134..317367 Mycobacterium bovis BCG str. Pasteur 1173P2 4696734 YP_976376.1 CDS BCG_0278 NC_008769.1 317375 317812 D Differs from Rv0240 by 1aa, S31A; hypothetical protein 317375..317812 Mycobacterium bovis BCG str. Pasteur 1173P2 4698779 YP_976377.1 CDS BCG_0279c NC_008769.1 317842 318684 R hypothetical protein complement(317842..318684) Mycobacterium bovis BCG str. Pasteur 1173P2 4698015 YP_976378.1 CDS fabG NC_008769.1 318695 320059 R Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(318695..320059) Mycobacterium bovis BCG str. Pasteur 1173P2 4695780 YP_976379.1 CDS fadA2 NC_008769.1 320201 321523 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 320201..321523 Mycobacterium bovis BCG str. Pasteur 1173P2 4697071 YP_976380.1 CDS fadE5 NC_008769.1 321829 323664 R Differs from Mb0250c by 1aa, N503D and from Rv0244c by 3aa, R394K, A479E, N503D; acyl-CoA dehydrogenase fadE5 complement(321829..323664) Mycobacterium bovis BCG str. Pasteur 1173P2 4698442 YP_976381.1 CDS BCG_0283 NC_008769.1 324036 324524 D oxidoreductase 324036..324524 Mycobacterium bovis BCG str. Pasteur 1173P2 4696256 YP_976382.1 CDS BCG_0284 NC_008769.1 324840 326150 D Differs from Rv0246 by 1aa, A129V; integral membrane protein 324840..326150 Mycobacterium bovis BCG str. Pasteur 1173P2 4698092 YP_976383.1 CDS BCG_0285c NC_008769.1 326147 326893 R catalyzes the fumarate and succinate interconversion; fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source; fumarate reductase iron-sulfur subunit complement(326147..326893) Mycobacterium bovis BCG str. Pasteur 1173P2 4698720 YP_976384.1 CDS sdhA NC_008769.1 326894 328834 R part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit complement(326894..328834) Mycobacterium bovis BCG str. Pasteur 1173P2 4695826 YP_976385.1 CDS BCG_0287c NC_008769.1 328865 329686 R succinate dehydrogenase membrane anchor subunit complement(328865..329686) Mycobacterium bovis BCG str. Pasteur 1173P2 4696782 YP_976386.1 CDS BCG_0288c NC_008769.1 329766 330059 R hypothetical protein complement(329766..330059) Mycobacterium bovis BCG str. Pasteur 1173P2 4697759 YP_976387.1 CDS hsp NC_008769.1 330204 330683 R heat shock protein hsp complement(330204..330683) Mycobacterium bovis BCG str. Pasteur 1173P2 4695359 YP_976388.1 CDS nirB NC_008769.1 330897 333458 D nitrite reductase NAD(P)H] large subunit 330897..333458 Mycobacterium bovis BCG str. Pasteur 1173P2 4697339 YP_976389.1 CDS nirD NC_008769.1 333484 333840 D nitrite reductase [NAD(P)H] small subunit nirD 333484..333840 Mycobacterium bovis BCG str. Pasteur 1173P2 4699206 YP_976390.1 CDS cobU NC_008769.1 333856 334380 R bifunctional cobalamin biosynthesis protein cobU: cobinamide kinase + cobinamide phosphate guanylyltransferase complement(333856..334380) Mycobacterium bovis BCG str. Pasteur 1173P2 4699207 YP_976391.1 CDS cobQ1 NC_008769.1 334405 335889 R catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation; cobyric acid synthase complement(334405..335889) Mycobacterium bovis BCG str. Pasteur 1173P2 4697940 YP_976392.1 CDS PPE2 NC_008769.1 335908 337578 R PPE family protein complement(335908..337578) Mycobacterium bovis BCG str. Pasteur 1173P2 4698555 YP_976393.1 CDS BCG_0295 NC_008769.1 337886 338104 D In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transition (c-t) leads to a truncated product in the 5' direction compared to Mycobacterium tuberculosis strain H37Rv (72 aa versus 124 aa); hypothetical protein 337886..338104 Mycobacterium bovis BCG str. Pasteur 1173P2 4697069 YP_976394.1 CDS BCG_0296c NC_008769.1 338325 338780 R hypothetical protein complement(338325..338780) Mycobacterium bovis BCG str. Pasteur 1173P2 4695376 YP_976395.1 CDS BCG_0297c NC_008769.1 338805 339548 R Differs from Rv0259c by 1aa, V182A; hypothetical protein complement(338805..339548) Mycobacterium bovis BCG str. Pasteur 1173P2 4698229 YP_976396.1 CDS BCG_0298c NC_008769.1 339545 340690 R catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; bifunctional uroporphyrinogen-III synthetase/response regulator domain-containing protein complement(339545..340690) Mycobacterium bovis BCG str. Pasteur 1173P2 4699345 YP_976397.1 CDS narK3 NC_008769.1 340790 342199 R integral membrane nitrite extrusion protein narK3 complement(340790..342199) Mycobacterium bovis BCG str. Pasteur 1173P2 4698915 YP_976398.1 CDS aac NC_008769.1 342340 342885 R aminoglycoside 2'-n-acetyltransferase aac complement(342340..342885) Mycobacterium bovis BCG str. Pasteur 1173P2 4697467 YP_976399.1 CDS BCG_0301c NC_008769.1 342895 343797 R hypothetical protein complement(342895..343797) Mycobacterium bovis BCG str. Pasteur 1173P2 4698700 YP_976400.1 CDS BCG_0302c NC_008769.1 343814 344446 R hypothetical protein complement(343814..344446) Mycobacterium bovis BCG str. Pasteur 1173P2 4699153 YP_976401.1 CDS BCG_0303c NC_008769.1 344542 345534 R Differs from Rv0265c and Mb0271c by 1aa, C313Y; periplasmic iron-transport lipoprotein complement(344542..345534) Mycobacterium bovis BCG str. Pasteur 1173P2 4697220 YP_976402.1 CDS oplA NC_008769.1 345556 349185 R 5-oxoprolinase complement(345556..349185) Mycobacterium bovis BCG str. Pasteur 1173P2 4695900 YP_976403.1 CDS narU NC_008769.1 349362 350753 D integral membrane nitrite extrusion protein narU 349362..350753 Mycobacterium bovis BCG str. Pasteur 1173P2 4698680 YP_976404.1 CDS BCG_0306c NC_008769.1 350795 351304 R hypothetical protein complement(350795..351304) Mycobacterium bovis BCG str. Pasteur 1173P2 4697469 YP_976405.1 CDS BCG_0307c NC_008769.1 351369 352562 R hypothetical protein complement(351369..352562) Mycobacterium bovis BCG str. Pasteur 1173P2 4698669 YP_976406.1 CDS fadD2 NC_008769.1 352598 354280 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 352598..354280 Mycobacterium bovis BCG str. Pasteur 1173P2 4698035 YP_976407.1 CDS fadE6 NC_008769.1 354297 356492 R acyl-CoA dehydrogenase fadE6 complement(354297..356492) Mycobacterium bovis BCG str. Pasteur 1173P2 4695420 YP_976408.1 CDS BCG_0310c NC_008769.1 356606 357739 R Differs from Mb0278c by 1aa, P164L; hypothetical protein complement(356606..357739) Mycobacterium bovis BCG str. Pasteur 1173P2 4696257 YP_976409.1 CDS BCG_0311c NC_008769.1 357736 358356 R transcriptional regulatory protein complement(357736..358356) Mycobacterium bovis BCG str. Pasteur 1173P2 4697726 YP_976410.1 CDS BCG_0312 NC_008769.1 358453 359034 D hypothetical protein 358453..359034 Mycobacterium bovis BCG str. Pasteur 1173P2 4697690 YP_976411.1 CDS BCG_0313c NC_008769.1 358964 359689 R Differs from Rv0275c by 1aa, L24S; TetR family transcriptional regulator complement(358964..359689) Mycobacterium bovis BCG str. Pasteur 1173P2 4699312 YP_976412.1 CDS BCG_0314 NC_008769.1 359779 360699 D hypothetical protein 359779..360699 Mycobacterium bovis BCG str. Pasteur 1173P2 4697725 YP_976413.1 CDS BCG_0315c NC_008769.1 360739 361167 R hypothetical protein complement(360739..361167) Mycobacterium bovis BCG str. Pasteur 1173P2 4696359 YP_976414.1 CDS BCG_0315A NC_008769.1 361191 361448 R Differs by 1 aa, Q24* from Rv0227A and Mb0351A; antitoxin complement(361191..361448) Mycobacterium bovis BCG str. Pasteur 1173P2 4697964 YP_976415.1 CDS PE_PGRS3a NC_008769.1 361533 364283 R In Mycobacterium tuberculosis strain H37Rv, PE_PGRS3 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovs BCG Pasteur, a large insertion leads to an extra copy of PE_PGRS3. Also, a frameshift due to single base deletion (t-*), splits this extra copy of PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b. Also differs from Mb0285c by an insertion of 144bp; PE-PGRS family protein complement(361533..364283) Mycobacterium bovis BCG str. Pasteur 1173P2 4697094 YP_976416.1 CDS PE_PGRS3 NC_008769.1 364547 367246 R In Mycobacterium bovis BCG Pasteur, a insertion of 66 bp lead to a longer product than to the homolog Mycobacterium bovis (899 aa versus 877 aa). In Mycobacterium bovis, 2 deletions, one of 18 bp and the other of 66 bp, and part of a 2780 bp insertion , leads to a shorter product with a different 3' end compared to its homolog in Mycobacterium tuberculosis strain H37Rv (877 aa versus 957 aa); PE-PGRS family protein complement(364547..367246) Mycobacterium bovis BCG str. Pasteur 1173P2 4697093 YP_976417.1 CDS PE_PGRS4 NC_008769.1 367496 370000 R In Mycobacterium bovis BCG Pasteur, 2 insertions each of 9 bp and a deletion of 9bp, lead to a longer product compared to its homolog in Mycobacterium bovis (834 aa versus 831 aa). In Mycobacterium bovis, 2 deletions each of 9 bp (ccgccggcg-* and cccgccggc-*), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (831 aa versus 837 aa); PE-PGRS family protein complement(367496..370000) Mycobacterium bovis BCG str. Pasteur 1173P2 4696182 YP_976418.1 CDS PPE3 NC_008769.1 370291 371901 D Differs from Rv0280 by 1 aa P337S; PPE family protein 370291..371901 Mycobacterium bovis BCG str. Pasteur 1173P2 4697095 YP_976419.1 CDS BCG_0321 NC_008769.1 371925 372833 D hypothetical protein 371925..372833 Mycobacterium bovis BCG str. Pasteur 1173P2 4697685 YP_976420.1 CDS BCG_0322 NC_008769.1 373058 374953 D Differs from Rv0282 by 1aa, A6E; hypothetical protein 373058..374953 Mycobacterium bovis BCG str. Pasteur 1173P2 4697218 YP_976421.1 CDS BCG_0323 NC_008769.1 374950 376566 D hypothetical protein 374950..376566 Mycobacterium bovis BCG str. Pasteur 1173P2 4697294 YP_976422.1 CDS BCG_0324 NC_008769.1 376563 380555 D Differs from Mb0292 by 1aa, A134T, and from Rv0284 by 2aa, A134T, R214P; hypothetical protein 376563..380555 Mycobacterium bovis BCG str. Pasteur 1173P2 4696654 YP_976423.1 CDS PE5 NC_008769.1 380552 380860 D PE family protein 380552..380860 Mycobacterium bovis BCG str. Pasteur 1173P2 4698280 YP_976424.1 CDS PPE4 NC_008769.1 380863 382404 D PPE family protein 380863..382404 Mycobacterium bovis BCG str. Pasteur 1173P2 4696202 YP_976425.1 CDS esxG NC_008769.1 382453 382746 D hypothetical protein 382453..382746 Mycobacterium bovis BCG str. Pasteur 1173P2 4697818 YP_976426.1 CDS esxH NC_008769.1 382776 383066 D low molecular weight protein antigen 7 cfp7 382776..383066 Mycobacterium bovis BCG str. Pasteur 1173P2 4698781 YP_976427.1 CDS BCG_0329 NC_008769.1 383077 383964 D hypothetical protein 383077..383964 Mycobacterium bovis BCG str. Pasteur 1173P2 4698809 YP_976428.1 CDS BCG_0330 NC_008769.1 384011 385429 D Differs from Rv0290 by 1aa, T400A; hypothetical protein 384011..385429 Mycobacterium bovis BCG str. Pasteur 1173P2 4698139 YP_976429.1 CDS BCG_0331 NC_008769.1 385426 386811 D protease 385426..386811 Mycobacterium bovis BCG str. Pasteur 1173P2 4699096 YP_976430.1 CDS BCG_0332 NC_008769.1 386808 387803 D Differs from Rv0292 by 1aa, D217N; hypothetical protein 386808..387803 Mycobacterium bovis BCG str. Pasteur 1173P2 4698120 YP_976431.1 CDS BCG_0333c NC_008769.1 387790 388992 R Differs from Rv0293c and Mb0301c by 1aa, S263G; hypothetical protein complement(387790..388992) Mycobacterium bovis BCG str. Pasteur 1173P2 4695810 YP_976432.1 CDS tam NC_008769.1 389099 389884 D catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 389099..389884 Mycobacterium bovis BCG str. Pasteur 1173P2 4696893 YP_976433.1 CDS BCG_0335c NC_008769.1 389873 390676 R hypothetical protein complement(389873..390676) Mycobacterium bovis BCG str. Pasteur 1173P2 4696339 YP_976434.1 CDS BCG_0336c NC_008769.1 390686 392083 R sulfatase complement(390686..392083) Mycobacterium bovis BCG str. Pasteur 1173P2 4697957 YP_976435.1 CDS PE_PGRS5 NC_008769.1 392262 394082 D In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (606 aa versus 591 aa); PE-PGRS family protein 392262..394082 Mycobacterium bovis BCG str. Pasteur 1173P2 4697403 YP_976436.1 CDS BCG_0338 NC_008769.1 394225 394452 D hypothetical protein 394225..394452 Mycobacterium bovis BCG str. Pasteur 1173P2 4695718 YP_976437.1 CDS BCG_0339 NC_008769.1 394449 394751 D Differs from Mb0307 by 1aa, S13N; hypothetical protein 394449..394751 Mycobacterium bovis BCG str. Pasteur 1173P2 4698968 YP_976438.1 CDS BCG_0340 NC_008769.1 394799 395020 D hypothetical protein 394799..395020 Mycobacterium bovis BCG str. Pasteur 1173P2 4698642 YP_976439.1 CDS BCG_0341 NC_008769.1 395017 395442 D hypothetical protein 395017..395442 Mycobacterium bovis BCG str. Pasteur 1173P2 4698422 YP_976440.1 CDS BCG_0342 NC_008769.1 395579 396211 D Differs from Mb0310 by 1aa A124V; TetR family transcriptional regulator 395579..396211 Mycobacterium bovis BCG str. Pasteur 1173P2 4695467 YP_976441.1 CDS BCG_0343 NC_008769.1 396208 397116 D dehydrogenase/reductase 396208..397116 Mycobacterium bovis BCG str. Pasteur 1173P2 4697256 YP_976442.1 CDS PPE5 NC_008769.1 397124 400567 R In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (g-*) leads to a shorter CDS (Mb0312c and BCG_0344c) equivalent to the 3' end of Rv0304c/PPE5. Differs from Rv0304c by 3aa, S481G, F708S, A955T, and 5 codon in-frame deletion at position 503; PPE family protein complement(397124..400567) Mycobacterium bovis BCG str. Pasteur 1173P2 4697219 YP_976443.1 CDS PPE6 NC_008769.1 400711 406638 R In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (t-*) resulting in the absence of a stop codon leads to a longer product. The second part of this CDS shares homology with the 5' end of Rv0304c/PPE5. Differs from Mb0313c by in-frame deletion of 10 codons; PPE family protein complement(400711..406638) Mycobacterium bovis BCG str. Pasteur 1173P2 4696876 YP_976444.1 CDS BCG_0346 NC_008769.1 406841 407512 D oxidoreductase 406841..407512 Mycobacterium bovis BCG str. Pasteur 1173P2 4698215 YP_976445.1 CDS BCG_0347c NC_008769.1 407500 407982 R hypothetical protein complement(407500..407982) Mycobacterium bovis BCG str. Pasteur 1173P2 4695774 YP_976446.1 CDS BCG_0348 NC_008769.1 408040 408756 D integral membrane protein 408040..408756 Mycobacterium bovis BCG str. Pasteur 1173P2 4697716 YP_976447.1 CDS BCG_0349 NC_008769.1 408858 409514 D hypothetical protein 408858..409514 Mycobacterium bovis BCG str. Pasteur 1173P2 4698232 YP_976448.1 CDS BCG_0350c NC_008769.1 409584 410075 R hypothetical protein complement(409584..410075) Mycobacterium bovis BCG str. Pasteur 1173P2 4695402 YP_976449.1 CDS BCG_0351 NC_008769.1 410099 411328 D hypothetical protein 410099..411328 Mycobacterium bovis BCG str. Pasteur 1173P2 4698435 YP_976450.1 CDS BCG_0352 NC_008769.1 411483 413345 D Differs from Rv0312 by 2aa, G159S, L563P; hypothetical protein 411483..413345 Mycobacterium bovis BCG str. Pasteur 1173P2 4698919 YP_976451.1 CDS BCG_0353 NC_008769.1 413417 413803 D hypothetical protein 413417..413803 Mycobacterium bovis BCG str. Pasteur 1173P2 4697371 YP_976452.1 CDS BCG_0354c NC_008769.1 413806 414468 R Differs from Rv0314c by 1aa, A184V; hypothetical protein complement(413806..414468) Mycobacterium bovis BCG str. Pasteur 1173P2 4697400 YP_976453.1 CDS BCG_0355 NC_008769.1 414529 415413 D Differs from Rv0315 by 1aa, T260K; beta-1,3-glucanase 414529..415413 Mycobacterium bovis BCG str. Pasteur 1173P2 4697754 YP_976454.1 CDS BCG_0356 NC_008769.1 415462 416076 D muconolactone isomerase 415462..416076 Mycobacterium bovis BCG str. Pasteur 1173P2 4695701 YP_976455.1 CDS glpQ2 NC_008769.1 416100 416870 R glycerophosphoryl diester phosphodiesterase glpQ2 complement(416100..416870) Mycobacterium bovis BCG str. Pasteur 1173P2 4698721 YP_976456.1 CDS BCG_0358c NC_008769.1 417232 418026 R Differs from Rv0318c by 1aa, A223G; integral membrane protein complement(417232..418026) Mycobacterium bovis BCG str. Pasteur 1173P2 4696329 YP_976457.1 CDS pcp NC_008769.1 418075 418743 D catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 418075..418743 Mycobacterium bovis BCG str. Pasteur 1173P2 4696347 YP_976458.1 CDS BCG_0360 NC_008769.1 418815 419477 D hypothetical protein 418815..419477 Mycobacterium bovis BCG str. Pasteur 1173P2 4698420 YP_976459.1 CDS dcd NC_008769.1 419509 420081 D Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 419509..420081 Mycobacterium bovis BCG str. Pasteur 1173P2 4697227 YP_976460.1 CDS udgA NC_008769.1 420187 421518 D udp-glucose 6-dehydrogenase udgA 420187..421518 Mycobacterium bovis BCG str. Pasteur 1173P2 4697262 YP_976461.1 CDS BCG_0363c NC_008769.1 421507 422178 R Differs from Rv0323c by 1aa, G142S; hypothetical protein complement(421507..422178) Mycobacterium bovis BCG str. Pasteur 1173P2 4696865 YP_976462.1 CDS BCG_0364 NC_008769.1 422279 422959 D Differs from Rv0324 by 1aa, A168T; ArsR family transcriptional regulator 422279..422959 Mycobacterium bovis BCG str. Pasteur 1173P2 4696364 YP_976463.1 CDS BCG_0365 NC_008769.1 422966 423655 D In Mycobacterium tuberculosis strain H37Rv, Rv0325 and Rv0326 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, the absence of a stop codon between Rv0325 and Rv0326 due to a single base transition (t-c) leads to single product; hypothetical protein 422966..423655 Mycobacterium bovis BCG str. Pasteur 1173P2 4695771 YP_976464.1 CDS cyp135A1 NC_008769.1 423623 424972 R Differs from Rv0327c by 1aa, Y100H; cytochrome P450 135A1 cyp135A1 complement(423623..424972) Mycobacterium bovis BCG str. Pasteur 1173P2 4698342 YP_976465.1 CDS BCG_0367 NC_008769.1 425038 425640 D TetR family transcriptional regulator 425038..425640 Mycobacterium bovis BCG str. Pasteur 1173P2 4697064 YP_976466.1 CDS BCG_0368c NC_008769.1 425621 426247 R Differs from Rv0329c by 1aa, S129W; hypothetical protein complement(425621..426247) Mycobacterium bovis BCG str. Pasteur 1173P2 4696759 YP_976467.1 CDS BCG_0369c NC_008769.1 426274 427014 R hypothetical protein complement(426274..427014) Mycobacterium bovis BCG str. Pasteur 1173P2 4697221 YP_976468.1 CDS BCG_0370 NC_008769.1 427128 428294 D dehydrogenase/reductase 427128..428294 Mycobacterium bovis BCG str. Pasteur 1173P2 4698412 YP_976469.1 CDS BCG_0371 NC_008769.1 428369 429154 D Differs from Rv0332 by 1aa, G198E; hypothetical protein 428369..429154 Mycobacterium bovis BCG str. Pasteur 1173P2 4696350 YP_976470.1 CDS BCG_0372 NC_008769.1 429181 429555 D hypothetical protein 429181..429555 Mycobacterium bovis BCG str. Pasteur 1173P2 4697767 YP_976471.1 CDS rmlA NC_008769.1 429585 430451 D glucose-1-phosphate thymidylyltransferase rmlA 429585..430451 Mycobacterium bovis BCG str. Pasteur 1173P2 4696702 YP_976472.1 CDS PE6 NC_008769.1 430462 430977 R Differs from Rv0335c and Mb0340 by 1aa P131T; PE family protein complement(430462..430977) Mycobacterium bovis BCG str. Pasteur 1173P2 4695583 YP_976473.1 CDS BCG_0375 NC_008769.1 431119 432630 D Differs from Rv0336 by 1aa, H496P; hypothetical protein 431119..432630 Mycobacterium bovis BCG str. Pasteur 1173P2 4696203 YP_976474.1 CDS aspC NC_008769.1 432800 434089 R broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase complement(432800..434089) Mycobacterium bovis BCG str. Pasteur 1173P2 4697963 YP_976475.1 CDS BCG_0377c NC_008769.1 434120 436768 R Differs from Rv0338c by 2aa, G506R, V621A; iron-sulfur-binding reductase complement(434120..436768) Mycobacterium bovis BCG str. Pasteur 1173P2 4695459 YP_976476.1 CDS BCG_0378c NC_008769.1 436877 439375 R transcriptional regulatory protein complement(436877..439375) Mycobacterium bovis BCG str. Pasteur 1173P2 4695752 YP_976477.1 CDS BCG_0379 NC_008769.1 439561 440100 D hypothetical protein 439561..440100 Mycobacterium bovis BCG str. Pasteur 1173P2 4697829 YP_976478.1 CDS iniB NC_008769.1 440289 441728 D isoniazid inductible gene protein iniB 440289..441728 Mycobacterium bovis BCG str. Pasteur 1173P2 4699344 YP_976479.1 CDS iniA NC_008769.1 441765 443687 D Differs from by 2aa, S88N, Q481H; isoniazid inductible gene protein iniA 441765..443687 Mycobacterium bovis BCG str. Pasteur 1173P2 4697078 YP_976480.1 CDS iniC NC_008769.1 443684 445165 D isoniazid inductible gene protein iniC 443684..445165 Mycobacterium bovis BCG str. Pasteur 1173P2 4697077 YP_976481.1 CDS lpqJ NC_008769.1 445308 445868 R lipoprotein lpqJ complement(445308..445868) Mycobacterium bovis BCG str. Pasteur 1173P2 4697432 YP_976482.1 CDS BCG_0384 NC_008769.1 445977 446387 D In Mycobacterium bovis, a frameshift due to a single base deletion (a-*) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv in Mycobacterium bovis BCG Pasteur; hypothetical protein 445977..446387 Mycobacterium bovis BCG str. Pasteur 1173P2 4698157 YP_976483.1 CDS ansP2 NC_008769.1 446429 447892 R l-asparagine permease ansP2 complement(446429..447892) Mycobacterium bovis BCG str. Pasteur 1173P2 4695803 YP_976484.1 CDS BCG_0386 NC_008769.1 448231 449217 D hypothetical protein 448231..449217 Mycobacterium bovis BCG str. Pasteur 1173P2 4697141 YP_976485.1 CDS BCG_0387 NC_008769.1 449220 449873 D transcriptional regulatory protein 449220..449873 Mycobacterium bovis BCG str. Pasteur 1173P2 4695384 YP_976486.1 CDS BCG_0388 NC_008769.1 449876 450535 D hypothetical protein 449876..450535 Mycobacterium bovis BCG str. Pasteur 1173P2 4695917 YP_976487.1 CDS dnaK NC_008769.1 450762 452639 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 450762..452639 Mycobacterium bovis BCG str. Pasteur 1173P2 4697869 YP_976488.1 CDS grpE NC_008769.1 452636 453343 D with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 452636..453343 Mycobacterium bovis BCG str. Pasteur 1173P2 4699017 YP_976489.1 CDS dnaJ1 NC_008769.1 453379 454566 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 453379..454566 Mycobacterium bovis BCG str. Pasteur 1173P2 4697812 YP_976490.1 CDS hspR NC_008769.1 454566 454946 D heat shock protein transcriptional regulator HspR 454566..454946 Mycobacterium bovis BCG str. Pasteur 1173P2 4699347 YP_976491.1 CDS PPE8 NC_008769.1 454969 465492 R In Mycobacterium tuberculosis strain H37Rv, PPE7 and PPE8 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 2 bp insertion (*-ta) resulting in the absence of a stop codon between the 2 genes, leads to a single product, and an altered C-terminus; PPE family protein complement(454969..465492) Mycobacterium bovis BCG str. Pasteur 1173P2 4696301 YP_976492.1 CDS BCG_0394c NC_008769.1 465643 466287 R hypothetical protein complement(465643..466287) Mycobacterium bovis BCG str. Pasteur 1173P2 4696417 YP_976493.1 CDS purA NC_008769.1 466284 467582 R catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase complement(466284..467582) Mycobacterium bovis BCG str. Pasteur 1173P2 4696674 YP_976494.1 CDS BCG_0396 NC_008769.1 467673 468320 D hypothetical protein 467673..468320 Mycobacterium bovis BCG str. Pasteur 1173P2 4699225 YP_976495.1 CDS BCG_0397 NC_008769.1 468331 469110 D Differs from Rv0359 by 1aa, T252A; integral membrane protein 468331..469110 Mycobacterium bovis BCG str. Pasteur 1173P2 4697373 YP_976496.1 CDS BCG_0398c NC_008769.1 469115 469552 R hypothetical protein complement(469115..469552) Mycobacterium bovis BCG str. Pasteur 1173P2 4696939 YP_976497.1 CDS BCG_0399 NC_008769.1 469635 470462 D hypothetical protein 469635..470462 Mycobacterium bovis BCG str. Pasteur 1173P2 4696308 YP_976498.1 CDS mgtE NC_008769.1 470684 472066 D Differs from Rv0362 by 1aa, V292A; Mg2+ transport transmembrane protein mgtE 470684..472066 Mycobacterium bovis BCG str. Pasteur 1173P2 4695690 YP_976499.1 CDS fba NC_008769.1 472078 473112 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(472078..473112) Mycobacterium bovis BCG str. Pasteur 1173P2 4699000 YP_976500.1 CDS BCG_0402 NC_008769.1 473208 473891 D Differs from Rv0364 by 1aa, L193I; hypothetical protein 473208..473891 Mycobacterium bovis BCG str. Pasteur 1173P2 4695684 YP_976501.1 CDS BCG_0403c NC_008769.1 473880 475010 R hypothetical protein complement(473880..475010) Mycobacterium bovis BCG str. Pasteur 1173P2 4695525 YP_976502.1 CDS BCG_0404c NC_008769.1 475035 475628 R hypothetical protein complement(475035..475628) Mycobacterium bovis BCG str. Pasteur 1173P2 4695589 YP_976503.1 CDS BCG_0405c NC_008769.1 475657 476046 R hypothetical protein complement(475657..476046) Mycobacterium bovis BCG str. Pasteur 1173P2 4698009 YP_976504.1 CDS BCG_0406c NC_008769.1 476127 477338 R Differs from Rv0368c by 1aa, H249R, and from Mb0375c by 1aa, G371S; hypothetical protein complement(476127..477338) Mycobacterium bovis BCG str. Pasteur 1173P2 4695835 YP_976505.1 CDS BCG_0407c NC_008769.1 477344 477859 R membrane oxidoreductase complement(477344..477859) Mycobacterium bovis BCG str. Pasteur 1173P2 4695431 YP_976506.1 CDS BCG_0408c NC_008769.1 477960 478856 R Differs from Rv0370c by 1aa, E201G; oxidoreductase complement(477960..478856) Mycobacterium bovis BCG str. Pasteur 1173P2 4697476 YP_976507.1 CDS BCG_0409c NC_008769.1 478853 479446 R hypothetical protein complement(478853..479446) Mycobacterium bovis BCG str. Pasteur 1173P2 4696983 YP_976508.1 CDS BCG_0410c NC_008769.1 479443 480198 R Differs from Rv0372c by 1aa, G161S; hypothetical protein complement(479443..480198) Mycobacterium bovis BCG str. Pasteur 1173P2 4695369 YP_976509.1 CDS BCG_0411c NC_008769.1 480217 482616 R Differs from Rv0373c by 1aa, S122F; carbon monoxyde dehydrogenase large chain complement(480217..482616) Mycobacterium bovis BCG str. Pasteur 1173P2 4696547 YP_976510.1 CDS BCG_0412c NC_008769.1 482613 483092 R carbon monoxyde dehydrogenase small chain complement(482613..483092) Mycobacterium bovis BCG str. Pasteur 1173P2 4696006 YP_976511.1 CDS BCG_0413c NC_008769.1 483107 483967 R carbon monoxyde dehydrogenase medium chain complement(483107..483967) Mycobacterium bovis BCG str. Pasteur 1173P2 4696726 YP_976512.1 CDS BCG_0414c NC_008769.1 484043 485185 R hypothetical protein complement(484043..485185) Mycobacterium bovis BCG str. Pasteur 1173P2 4697103 YP_976513.1 CDS BCG_0415 NC_008769.1 485234 486199 D Differs from Rv0377 by 1aa, R302P; LysR family transcriptional regulator 485234..486199 Mycobacterium bovis BCG str. Pasteur 1173P2 4696588 YP_976514.1 CDS BCG_0416 NC_008769.1 486450 486671 D hypothetical protein 486450..486671 Mycobacterium bovis BCG str. Pasteur 1173P2 4697455 YP_976515.1 CDS secE2 NC_008769.1 486790 487005 D protein transport protein secE2 486790..487005 Mycobacterium bovis BCG str. Pasteur 1173P2 4697673 YP_976516.1 CDS BCG_0418c NC_008769.1 487081 487632 R rna methyltransferase complement(487081..487632) Mycobacterium bovis BCG str. Pasteur 1173P2 4697708 YP_976517.1 CDS BCG_0419c NC_008769.1 487728 488636 R hypothetical protein complement(487728..488636) Mycobacterium bovis BCG str. Pasteur 1173P2 4697216 YP_976518.1 CDS pyrE NC_008769.1 488654 489193 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(488654..489193) Mycobacterium bovis BCG str. Pasteur 1173P2 4697528 YP_976519.1 CDS BCG_0421c NC_008769.1 489274 490128 R hypothetical protein complement(489274..490128) Mycobacterium bovis BCG str. Pasteur 1173P2 4697784 YP_976520.1 CDS clpB NC_008769.1 490269 492815 R endopeptidase ATP binding protein subunit B complement(490269..492815) Mycobacterium bovis BCG str. Pasteur 1173P2 4697361 YP_976521.1 CDS BCG_0423 NC_008769.1 492948 494120 D monooxygenase 492948..494120 Mycobacterium bovis BCG str. Pasteur 1173P2 4697010 YP_976522.1 CDS BCG_0424 NC_008769.1 494224 497481 D Differs from Mb0393 by 1aa, D902A; LuxR family transcriptional regulator 494224..497481 Mycobacterium bovis BCG str. Pasteur 1173P2 4697702 YP_976523.1 CDS PPE9 NC_008769.1 497485 498816 R In Mycobacterium tuberculosis strain H37Rv, Rv0388c and Rv0387c exist as 2 separate genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, 3 different base substitutions, the first of 14 bases, the second of 8 bases (tctacagt-gctacagg), and lastly of 28 bases, leads to a longer single product; Differs from Mb0394c by 1aa, T361A; PPE family protein complement(497485..498816) Mycobacterium bovis BCG str. Pasteur 1173P2 4696958 YP_976524.1 CDS purT NC_008769.1 499150 500409 D non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 499150..500409 Mycobacterium bovis BCG str. Pasteur 1173P2 4696418 YP_976525.1 CDS BCG_0427 NC_008769.1 500406 500828 D hypothetical protein 500406..500828 Mycobacterium bovis BCG str. Pasteur 1173P2 4696059 YP_976526.1 CDS metZ NC_008769.1 500825 502045 D O-succinylhomoserine sulfhydrylase 500825..502045 Mycobacterium bovis BCG str. Pasteur 1173P2 4696910 YP_976527.1 CDS ndhA NC_008769.1 502042 503454 R Differs from Rv0392c by 1aa, A241V; membrane NADH dehydrogenase ndhA complement(502042..503454) Mycobacterium bovis BCG str. Pasteur 1173P2 4699106 YP_976528.1 CDS BCG_0430 NC_008769.1 503596 504921 D hypothetical protein 503596..504921 Mycobacterium bovis BCG str. Pasteur 1173P2 4696138 YP_976529.1 CDS BCG_0431c NC_008769.1 504937 505656 R hypothetical protein complement(504937..505656) Mycobacterium bovis BCG str. Pasteur 1173P2 4697365 YP_976530.1 CDS BCG_0432 NC_008769.1 505755 506159 D Differs from Rv0395 by 1aa, A80V; hypothetical protein 505755..506159 Mycobacterium bovis BCG str. Pasteur 1173P2 4696421 YP_976531.1 CDS BCG_0433 NC_008769.1 506165 506557 D hypothetical protein 506165..506557 Mycobacterium bovis BCG str. Pasteur 1173P2 4696027 YP_976532.1 CDS BCG_0434 NC_008769.1 506631 506999 D hypothetical protein 506631..506999 Mycobacterium bovis BCG str. Pasteur 1173P2 4695980 YP_976533.1 CDS BCG_0435c NC_008769.1 507494 508135 R hypothetical protein complement(507494..508135) Mycobacterium bovis BCG str. Pasteur 1173P2 4697139 YP_976534.1 CDS lpqK NC_008769.1 508142 509371 R lipoprotein lpqK complement(508142..509371) Mycobacterium bovis BCG str. Pasteur 1173P2 4695965 YP_976535.1 CDS fadE7 NC_008769.1 509381 510568 R acyl-CoA dehydrogenase fadE7 complement(509381..510568) Mycobacterium bovis BCG str. Pasteur 1173P2 4698158 YP_976536.1 CDS BCG_0438 NC_008769.1 510604 510975 D hypothetical protein 510604..510975 Mycobacterium bovis BCG str. Pasteur 1173P2 4696258 YP_976537.1 CDS mmpL1b NC_008769.1 511170 512273 R In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b; transmembrane transport protein mmpL1b complement(511170..512273) Mycobacterium bovis BCG str. Pasteur 1173P2 4697008 YP_976538.1 CDS mmpL1a NC_008769.1 512270 514045 R In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b; Differs from Rv0402c by 1aa, P451L; transmembrane transport protein mmpL1a complement(512270..514045) Mycobacterium bovis BCG str. Pasteur 1173P2 4695519 YP_976539.1 CDS mmpS1 NC_008769.1 514042 514470 R membrane protein mmpS1 complement(514042..514470) Mycobacterium bovis BCG str. Pasteur 1173P2 4695518 YP_976540.1 CDS fadD30 NC_008769.1 514791 516548 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 514791..516548 Mycobacterium bovis BCG str. Pasteur 1173P2 4697490 YP_976541.1 CDS pks6a NC_008769.1 516545 517927 D In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to single base insertion (*-g) splits pks6 into 2 parts, pks6a and pks6b; membrane bound polyketide synthase pks6a 516545..517927 Mycobacterium bovis BCG str. Pasteur 1173P2 4699138 YP_976542.1 CDS pks6b NC_008769.1 517914 520754 D In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis, a frameshift due to single base insertion (*-g), splits pks6 into 2 parts, pks6a and pks6b; Differs from Mb0413 by 1aa, M921V; membrane bound polyketide synthase pks6b 517914..520754 Mycobacterium bovis BCG str. Pasteur 1173P2 4696577 YP_976543.1 CDS BCG_0445c NC_008769.1 520702 521520 R beta-lactamase complement(520702..521520) Mycobacterium bovis BCG str. Pasteur 1173P2 4696578 YP_976544.1 CDS fgd1 NC_008769.1 521598 522608 D glucose-6-phosphate dehydrogenase 521598..522608 Mycobacterium bovis BCG str. Pasteur 1173P2 4696963 YP_976545.1 CDS pta NC_008769.1 522601 524673 D catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 522601..524673 Mycobacterium bovis BCG str. Pasteur 1173P2 4695793 YP_976546.1 CDS ackA NC_008769.1 524666 525823 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 524666..525823 Mycobacterium bovis BCG str. Pasteur 1173P2 4697315 YP_976547.1 CDS pknG NC_008769.1 525877 528129 R Serine/threonine-protein kinase pknG complement(525877..528129) Mycobacterium bovis BCG str. Pasteur 1173P2 4698962 YP_976548.1 CDS glnH NC_008769.1 528129 529115 R glutamine-binding lipoprotein glnH complement(528129..529115) Mycobacterium bovis BCG str. Pasteur 1173P2 4697522 YP_976549.1 CDS BCG_0451c NC_008769.1 529115 530434 R Differs from Rv0412c by 1aa, Y355D; hypothetical protein complement(529115..530434) Mycobacterium bovis BCG str. Pasteur 1173P2 4697947 YP_976550.1 CDS mutT3 NC_008769.1 530528 531181 D mutator protein MutT3 530528..531181 Mycobacterium bovis BCG str. Pasteur 1173P2 4696193 YP_976551.1 CDS thiE NC_008769.1 531165 531833 R Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase complement(531165..531833) Mycobacterium bovis BCG str. Pasteur 1173P2 4695711 YP_976552.1 CDS thiO NC_008769.1 531963 532985 D Differs from Rv0415 by 1aa, A158V; thiamine biosynthesis oxidoreductase thiO 531963..532985 Mycobacterium bovis BCG str. Pasteur 1173P2 4695451 YP_976553.1 CDS thiS NC_008769.1 532982 533188 D with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 532982..533188 Mycobacterium bovis BCG str. Pasteur 1173P2 4697958 YP_976554.1 CDS thiG NC_008769.1 533181 533939 D functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 533181..533939 Mycobacterium bovis BCG str. Pasteur 1173P2 4697959 YP_976555.1 CDS lpqL NC_008769.1 534311 535813 D lipoprotein aminopeptidase lpqL 534311..535813 Mycobacterium bovis BCG str. Pasteur 1173P2 4695452 YP_976556.1 CDS lpqM NC_008769.1 535901 537397 D Differs from Rv0419 by 2aa, T73A, T297A, and from Mb0427 by 1aa, T73A; lipoprotein peptidase lpqM 535901..537397 Mycobacterium bovis BCG str. Pasteur 1173P2 4698190 YP_976557.1 CDS BCG_0459c NC_008769.1 537376 537786 R Differs from Rv0420c by 1aa, G21E; hypothetical protein complement(537376..537786) Mycobacterium bovis BCG str. Pasteur 1173P2 4698191 YP_976558.1 CDS BCG_0460c NC_008769.1 537947 538576 R hypothetical protein complement(537947..538576) Mycobacterium bovis BCG str. Pasteur 1173P2 4695996 YP_976559.1 CDS thiD NC_008769.1 538573 539370 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(538573..539370) Mycobacterium bovis BCG str. Pasteur 1173P2 4696047 YP_976560.1 CDS thiC NC_008769.1 539397 541040 R required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC complement(539397..541040) Mycobacterium bovis BCG str. Pasteur 1173P2 4695450 YP_976561.1 CDS BCG_0463c NC_008769.1 541192 541467 R hypothetical protein complement(541192..541467) Mycobacterium bovis BCG str. Pasteur 1173P2 4695449 YP_976562.1 CDS ctpH NC_008769.1 541517 546136 R Differs from Rv0425c by 1aa, A222E; metal cation transporting P-type atpase ctpH complement(541517..546136) Mycobacterium bovis BCG str. Pasteur 1173P2 4697004 YP_976563.1 CDS BCG_0465c NC_008769.1 546188 546631 R hypothetical protein complement(546188..546631) Mycobacterium bovis BCG str. Pasteur 1173P2 4695617 YP_976564.1 CDS xthA NC_008769.1 546832 547707 R exodeoxyribonuclease III protein xthA complement(546832..547707) Mycobacterium bovis BCG str. Pasteur 1173P2 4696947 YP_976565.1 CDS BCG_0467c NC_008769.1 547710 548618 R Differs from Rv0428c by 1aa G149D; hypothetical protein complement(547710..548618) Mycobacterium bovis BCG str. Pasteur 1173P2 4697557 YP_976566.1 CDS def NC_008769.1 548618 549211 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(548618..549211) Mycobacterium bovis BCG str. Pasteur 1173P2 4696950 YP_976567.1 CDS BCG_0469 NC_008769.1 549548 549856 D hypothetical protein 549548..549856 Mycobacterium bovis BCG str. Pasteur 1173P2 4698670 YP_976568.1 CDS BCG_0470 NC_008769.1 549888 550382 D Differs from Rv0431 by 2aa, G38V, A87T; tuberculin-like protein 549888..550382 Mycobacterium bovis BCG str. Pasteur 1173P2 4696932 YP_976569.1 CDS sodC NC_008769.1 550415 551137 D periplasmic superoxide dismutase [Cu-Zn] sodC 550415..551137 Mycobacterium bovis BCG str. Pasteur 1173P2 4697120 YP_976570.1 CDS BCG_0472 NC_008769.1 551139 552269 D ATP-dependent carboxylate-amine ligase; carboxylate-amine ligase 551139..552269 Mycobacterium bovis BCG str. Pasteur 1173P2 4695621 YP_976571.1 CDS BCG_0473 NC_008769.1 552329 552982 D Differs from Rv0434 by 1aa, A190T; hypothetical protein 552329..552982 Mycobacterium bovis BCG str. Pasteur 1173P2 4696913 YP_976572.1 CDS BCG_0474c NC_008769.1 553162 555348 R atpase complement(553162..555348) Mycobacterium bovis BCG str. Pasteur 1173P2 4695865 YP_976573.1 CDS pssA NC_008769.1 555345 556205 R Differs from Rv0436c by 1aa, V167G; CDP-diacylglycerol--serine o-phosphatidyltransferase pssA complement(555345..556205) Mycobacterium bovis BCG str. Pasteur 1173P2 4697100 YP_976574.1 CDS psd NC_008769.1 556202 556897 R catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase complement(556202..556897) Mycobacterium bovis BCG str. Pasteur 1173P2 4696824 YP_976575.1 CDS moeA2 NC_008769.1 556958 558175 R Differs from Rv0438c by 1aa, I15M; molybdopterin biosynthesis protein moeA2 complement(556958..558175) Mycobacterium bovis BCG str. Pasteur 1173P2 4697279 YP_976576.1 CDS BCG_0478c NC_008769.1 558194 559129 R short chain dehydrogenase complement(558194..559129) Mycobacterium bovis BCG str. Pasteur 1173P2 4697171 YP_976577.1 CDS groEL NC_008769.1 559423 561045 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 559423..561045 Mycobacterium bovis BCG str. Pasteur 1173P2 4697235 YP_976578.1 CDS BCG_0480c NC_008769.1 561111 561539 R hypothetical protein complement(561111..561539) Mycobacterium bovis BCG str. Pasteur 1173P2 4698395 YP_976579.1 CDS PPE10 NC_008769.1 561566 563005 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transition (g-a) creates an in-frame stop at codon 8, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (479 aa versus 487 aa). Differs from Mb0450c by 1aa, T214K, and from Rv0442c by 2aa, E23K, T214K; PPE family protein complement(561566..563005) Mycobacterium bovis BCG str. Pasteur 1173P2 4696548 YP_976580.1 CDS BCG_0482 NC_008769.1 563211 563726 D hypothetical protein 563211..563726 Mycobacterium bovis BCG str. Pasteur 1173P2 4696161 YP_976581.1 CDS BCG_0483c NC_008769.1 563906 564604 R Differs from Rv0444c by 2aa, D107G, E184G; hypothetical protein complement(563906..564604) Mycobacterium bovis BCG str. Pasteur 1173P2 4696024 YP_976582.1 CDS sigK NC_008769.1 564648 565211 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins; RNA polymerase sigma factor SigK complement(564648..565211) Mycobacterium bovis BCG str. Pasteur 1173P2 4697108 YP_976583.1 CDS BCG_0485c NC_008769.1 565260 566030 R hypothetical protein complement(565260..566030) Mycobacterium bovis BCG str. Pasteur 1173P2 4696443 YP_976584.1 CDS ufaA1 NC_008769.1 566039 567322 R cyclopropane-fatty-acyl-phospholipid synthase ufaA1 complement(566039..567322) Mycobacterium bovis BCG str. Pasteur 1173P2 4697593 YP_976585.1 CDS BCG_0487c NC_008769.1 567319 567984 R hypothetical protein complement(567319..567984) Mycobacterium bovis BCG str. Pasteur 1173P2 4696866 YP_976586.1 CDS BCG_0488c NC_008769.1 568044 569363 R hypothetical protein complement(568044..569363) Mycobacterium bovis BCG str. Pasteur 1173P2 4696611 YP_976587.1 CDS mmpL4 NC_008769.1 569403 572306 R Differs from Mb0458c by 1aa, A314T; transmembrane transport protein mmpL4 complement(569403..572306) Mycobacterium bovis BCG str. Pasteur 1173P2 4697364 YP_976588.1 CDS mmpS4 NC_008769.1 572303 572725 R membrane protein mmpS4 complement(572303..572725) Mycobacterium bovis BCG str. Pasteur 1173P2 4695522 YP_976589.1 CDS BCG_0491 NC_008769.1 572957 573667 D transcriptional regulatory protein 572957..573667 Mycobacterium bovis BCG str. Pasteur 1173P2 4697493 YP_976590.1 CDS PPE11 NC_008769.1 573989 575545 D PPE family protein 573989..575545 Mycobacterium bovis BCG str. Pasteur 1173P2 4696019 YP_976591.1 CDS BCG_0493 NC_008769.1 575650 576000 D hypothetical protein 575650..576000 Mycobacterium bovis BCG str. Pasteur 1173P2 4696162 YP_976592.1 CDS BCG_0494c NC_008769.1 576190 576636 R hypothetical protein complement(576190..576636) Mycobacterium bovis BCG str. Pasteur 1173P2 4697757 YP_976593.1 CDS echA2 NC_008769.1 576704 577618 R catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(576704..577618) Mycobacterium bovis BCG str. Pasteur 1173P2 4695981 YP_976594.1 CDS BCG_0496c NC_008769.1 577891 578172 R hypothetical protein complement(577891..578172) Mycobacterium bovis BCG str. Pasteur 1173P2 4697927 YP_976595.1 CDS BCG_0497c NC_008769.1 578401 580431 R In Mycobacterium bovis and in Mycobacterium bovis BCG, a possible RBS upstream leads to an earlier start resulting in a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (676 aa versus 673 aa); peptidase complement(578401..580431) Mycobacterium bovis BCG str. Pasteur 1173P2 4696285 YP_976596.1 CDS BCG_0498 NC_008769.1 580490 582013 D aldehyde dehydrogenase 580490..582013 Mycobacterium bovis BCG str. Pasteur 1173P2 4696960 YP_976597.1 CDS BCG_0499 NC_008769.1 582013 582504 D hypothetical protein 582013..582504 Mycobacterium bovis BCG str. Pasteur 1173P2 4696311 YP_976598.1 CDS BCG_0500 NC_008769.1 582564 582803 D hypothetical protein 582564..582803 Mycobacterium bovis BCG str. Pasteur 1173P2 4695663 YP_976599.1 CDS BCG_0501 NC_008769.1 582841 583365 D hypothetical protein 582841..583365 Mycobacterium bovis BCG str. Pasteur 1173P2 4695991 YP_976600.1 CDS lpd NC_008769.1 583429 584823 D E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; dihydrolipoamide dehydrogenase 583429..584823 Mycobacterium bovis BCG str. Pasteur 1173P2 4696921 YP_976601.1 CDS BCG_0503 NC_008769.1 584831 585124 D hypothetical protein 584831..585124 Mycobacterium bovis BCG str. Pasteur 1173P2 4695787 YP_976602.1 CDS BCG_0504c NC_008769.1 585128 585700 R hypothetical protein complement(585128..585700) Mycobacterium bovis BCG str. Pasteur 1173P2 4696021 YP_976603.1 CDS BCG_0505c NC_008769.1 585697 587121 R Differs from Rv0465c by 2aa, D36N, R106C, and from Mb0474c by 1aa, R326Q; transcriptional regulatory protein complement(585697..587121) Mycobacterium bovis BCG str. Pasteur 1173P2 4695978 YP_976604.1 CDS BCG_0506 NC_008769.1 587273 588067 D hypothetical protein 587273..588067 Mycobacterium bovis BCG str. Pasteur 1173P2 4696015 YP_976605.1 CDS icl NC_008769.1 588342 589628 D isocitrate lyase icl 588342..589628 Mycobacterium bovis BCG str. Pasteur 1173P2 4696942 YP_976606.1 CDS fadB2 NC_008769.1 589710 590570 D converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase 589710..590570 Mycobacterium bovis BCG str. Pasteur 1173P2 4699215 YP_976607.1 CDS umaA1 NC_008769.1 590703 591563 D mycolic acid synthase umaA1 590703..591563 Mycobacterium bovis BCG str. Pasteur 1173P2 4698840 YP_976608.1 CDS pcaA NC_008769.1 591663 592526 R mycolic acid synthase PcaA complement(591663..592526) Mycobacterium bovis BCG str. Pasteur 1173P2 4696500 YP_976609.1 CDS BCG_0511c NC_008769.1 592669 593109 R hypothetical protein complement(592669..593109) Mycobacterium bovis BCG str. Pasteur 1173P2 4698836 YP_976610.1 CDS BCG_0512c NC_008769.1 593040 593528 R hypothetical protein complement(593040..593528) Mycobacterium bovis BCG str. Pasteur 1173P2 4697054 YP_976611.1 CDS BCG_0513c NC_008769.1 593538 594242 R Differs from Rv0472c and Mb0482c by 1aa, D162G; TetR family transcriptional regulator complement(593538..594242) Mycobacterium bovis BCG str. Pasteur 1173P2 4697053 YP_976612.1 CDS BCG_0514 NC_008769.1 594379 595749 D Differs from Rv0473 by 1aa, R5K; hypothetical protein 594379..595749 Mycobacterium bovis BCG str. Pasteur 1173P2 4696920 YP_976613.1 CDS BCG_0515 NC_008769.1 595836 596258 D transcriptional regulatory protein 595836..596258 Mycobacterium bovis BCG str. Pasteur 1173P2 4696029 YP_976614.1 CDS hbhA NC_008769.1 596612 597211 D Heparin binding hemagglutinin hbhA 596612..597211 Mycobacterium bovis BCG str. Pasteur 1173P2 4696475 YP_976615.1 CDS BCG_0517 NC_008769.1 597323 597586 D hypothetical protein 597323..597586 Mycobacterium bovis BCG str. Pasteur 1173P2 4695480 YP_976616.1 CDS BCG_0518 NC_008769.1 597591 598037 D hypothetical protein 597591..598037 Mycobacterium bovis BCG str. Pasteur 1173P2 4695961 YP_976617.1 CDS deoC NC_008769.1 598037 598711 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 598037..598711 Mycobacterium bovis BCG str. Pasteur 1173P2 4696966 YP_976618.1 CDS BCG_0520c NC_008769.1 598736 599782 R hypothetical protein complement(598736..599782) Mycobacterium bovis BCG str. Pasteur 1173P2 4698988 YP_976619.1 CDS BCG_0521c NC_008769.1 599779 600714 R In Mycobacterium bovis, a 56 bp deletion results in a different NH2 part and leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (311 aa versus 340 aa); hypothetical protein complement(599779..600714) Mycobacterium bovis BCG str. Pasteur 1173P2 4696965 YP_976620.1 CDS BCG_0522c NC_008769.1 600747 601271 R hypothetical protein complement(600747..601271) Mycobacterium bovis BCG str. Pasteur 1173P2 4696954 YP_976621.1 CDS murB NC_008769.1 601298 602407 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 601298..602407 Mycobacterium bovis BCG str. Pasteur 1173P2 4696005 YP_976622.1 CDS lprQ NC_008769.1 602469 603824 D lipoprotein lprQ 602469..603824 Mycobacterium bovis BCG str. Pasteur 1173P2 4699152 YP_976623.1 CDS BCG_0525c NC_008769.1 603805 604560 R Differs from Rv0484c by 1aa, L140I; short-chain type oxidoreductase complement(603805..604560) Mycobacterium bovis BCG str. Pasteur 1173P2 4697257 YP_976624.1 CDS BCG_0526 NC_008769.1 604743 606059 D transcriptional regulatory protein 604743..606059 Mycobacterium bovis BCG str. Pasteur 1173P2 4696156 YP_976625.1 CDS BCG_0527 NC_008769.1 606107 607549 D mannosyltransferase 606107..607549 Mycobacterium bovis BCG str. Pasteur 1173P2 4696986 YP_976626.1 CDS BCG_0528 NC_008769.1 607546 608097 D hypothetical protein 607546..608097 Mycobacterium bovis BCG str. Pasteur 1173P2 4696048 YP_976627.1 CDS BCG_0529 NC_008769.1 608539 609144 D integral membrane protein 608539..609144 Mycobacterium bovis BCG str. Pasteur 1173P2 4696914 YP_976628.1 CDS gpmA NC_008769.1 609301 610050 D 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 609301..610050 Mycobacterium bovis BCG str. Pasteur 1173P2 4696951 YP_976629.1 CDS senX3 NC_008769.1 610224 611456 D Differs from Rv0490 and Mb0500 by 1aa, S109F; two component sensor histidine kinase senX3 610224..611456 Mycobacterium bovis BCG str. Pasteur 1173P2 4697840 YP_976630.1 CDS regX3 NC_008769.1 611607 612290 D Differs from Rv0491 and Mb0501 by 1aa, T18A; two component sensory transduction protein RegX3 611607..612290 Mycobacterium bovis BCG str. Pasteur 1173P2 4697882 YP_976631.1 CDS BCG_0533c NC_008769.1 612287 614176 R Differs from Rv0492c by 1aa, F520L; oxidoreductase GMC-type complement(612287..614176) Mycobacterium bovis BCG str. Pasteur 1173P2 4695842 YP_976632.1 CDS BCG_0534c NC_008769.1 614173 614502 R hypothetical protein complement(614173..614502) Mycobacterium bovis BCG str. Pasteur 1173P2 4697132 YP_976633.1 CDS BCG_0535c NC_008769.1 614499 615488 R Differs from Rv0493c by 1aa, G174S; hypothetical protein complement(614499..615488) Mycobacterium bovis BCG str. Pasteur 1173P2 4697063 YP_976634.1 CDS BCG_0536 NC_008769.1 615493 616221 D GntR family transcriptional regulator 615493..616221 Mycobacterium bovis BCG str. Pasteur 1173P2 4695972 YP_976635.1 CDS BCG_0537c NC_008769.1 616222 617112 R hypothetical protein complement(616222..617112) Mycobacterium bovis BCG str. Pasteur 1173P2 4696044 YP_976636.1 CDS BCG_0538 NC_008769.1 617192 618178 D hypothetical protein 617192..618178 Mycobacterium bovis BCG str. Pasteur 1173P2 4695967 YP_976637.1 CDS BCG_0539 NC_008769.1 618175 619107 D hypothetical protein 618175..619107 Mycobacterium bovis BCG str. Pasteur 1173P2 4696468 YP_976638.1 CDS BCG_0540 NC_008769.1 619123 619965 D hypothetical protein 619123..619965 Mycobacterium bovis BCG str. Pasteur 1173P2 4695575 YP_976639.1 CDS BCG_0541 NC_008769.1 619981 620856 D hypothetical protein 619981..620856 Mycobacterium bovis BCG str. Pasteur 1173P2 4696935 YP_976640.1 CDS proC NC_008769.1 620881 621768 D catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 620881..621768 Mycobacterium bovis BCG str. Pasteur 1173P2 4696151 YP_976641.1 CDS BCG_0543 NC_008769.1 621909 622145 D hypothetical protein 621909..622145 Mycobacterium bovis BCG str. Pasteur 1173P2 4696514 YP_976642.1 CDS galE2 NC_008769.1 622452 623582 D udp-glucose 4-epimerase galE2 622452..623582 Mycobacterium bovis BCG str. Pasteur 1173P2 4695969 YP_976643.1 CDS BCG_0545 NC_008769.1 623589 624665 D hypothetical protein 623589..624665 Mycobacterium bovis BCG str. Pasteur 1173P2 4695531 YP_976644.1 CDS cmaA2 NC_008769.1 624669 625577 R cyclopropane-fatty-acyl-phospholipid synthase 2 cmaA2 complement(624669..625577) Mycobacterium bovis BCG str. Pasteur 1173P2 4696917 YP_976645.1 CDS BCG_0547c NC_008769.1 625600 626100 R hypothetical protein complement(625600..626100) Mycobacterium bovis BCG str. Pasteur 1173P2 4698572 YP_976646.1 CDS serB1 NC_008769.1 626262 627383 R phosphoserine phosphatase serB1 complement(626262..627383) Mycobacterium bovis BCG str. Pasteur 1173P2 4695979 YP_976647.1 CDS mmpS2 NC_008769.1 627557 628000 D membrane protein mmpS2 627557..628000 Mycobacterium bovis BCG str. Pasteur 1173P2 4696249 YP_976648.1 CDS mmpL2 NC_008769.1 627997 630903 D Differs from Mb0519 by 1aa, D119H, and from Rv0507 by 3aa, H426R, Y509D, C722S; transmembrane transport protein mmpL2 627997..630903 Mycobacterium bovis BCG str. Pasteur 1173P2 4697491 YP_976649.1 CDS BCG_0551 NC_008769.1 630896 631189 D hypothetical protein 630896..631189 Mycobacterium bovis BCG str. Pasteur 1173P2 4695520 YP_976650.1 CDS hemA NC_008769.1 631239 632645 D catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 631239..632645 Mycobacterium bovis BCG str. Pasteur 1173P2 4696020 YP_976651.1 CDS hemC NC_008769.1 632655 633584 D transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 632655..633584 Mycobacterium bovis BCG str. Pasteur 1173P2 4695483 YP_976652.1 CDS hemD NC_008769.1 633617 635314 D uroporphyrin-III c-methyltransferase hemD 633617..635314 Mycobacterium bovis BCG str. Pasteur 1173P2 4698902 YP_976653.1 CDS hemB NC_008769.1 635400 636389 D catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 635400..636389 Mycobacterium bovis BCG str. Pasteur 1173P2 4698903 YP_976654.1 CDS BCG_0556 NC_008769.1 636402 636950 D hypothetical protein 636402..636950 Mycobacterium bovis BCG str. Pasteur 1173P2 4698901 YP_976655.1 CDS BCG_0557 NC_008769.1 636947 637246 D Differs from Mb0527 and Rv0514 by 1aa, G23A; hypothetical protein 636947..637246 Mycobacterium bovis BCG str. Pasteur 1173P2 4696980 YP_976656.1 CDS BCG_0558 NC_008769.1 637349 638860 D hypothetical protein 637349..638860 Mycobacterium bovis BCG str. Pasteur 1173P2 4696170 YP_976657.1 CDS BCG_0559c NC_008769.1 638857 639333 R hypothetical protein complement(638857..639333) Mycobacterium bovis BCG str. Pasteur 1173P2 4696072 YP_976658.1 CDS BCG_0560 NC_008769.1 639544 640854 D Differs from Rv0517 by 1aa, G394D; membrane acyltransferase 639544..640854 Mycobacterium bovis BCG str. Pasteur 1173P2 4695960 YP_976659.1 CDS BCG_0561 NC_008769.1 640986 641681 D hypothetical protein 640986..641681 Mycobacterium bovis BCG str. Pasteur 1173P2 4697161 YP_976660.1 CDS BCG_0562c NC_008769.1 641970 642872 R hypothetical protein complement(641970..642872) Mycobacterium bovis BCG str. Pasteur 1173P2 4695968 YP_976661.1 CDS BCG_0563 NC_008769.1 643053 643403 D methyltransferase/methylase 643053..643403 Mycobacterium bovis BCG str. Pasteur 1173P2 4696025 YP_976662.1 CDS BCG_0564 NC_008769.1 643396 643701 D methyltransferase/methylase 643396..643701 Mycobacterium bovis BCG str. Pasteur 1173P2 4696929 YP_976663.1 CDS gabP NC_008769.1 643836 645140 D 4-amino butyrate transport carrier 643836..645140 Mycobacterium bovis BCG str. Pasteur 1173P2 4695677 YP_976664.1 CDS BCG_0566c NC_008769.1 645124 645519 R hypothetical protein complement(645124..645519) Mycobacterium bovis BCG str. Pasteur 1173P2 4695550 YP_976665.1 CDS hemL NC_008769.1 645633 647021 D Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 645633..647021 Mycobacterium bovis BCG str. Pasteur 1173P2 4695466 YP_976666.1 CDS BCG_0568 NC_008769.1 647021 647629 D hypothetical protein 647021..647629 Mycobacterium bovis BCG str. Pasteur 1173P2 4698929 YP_976667.1 CDS BCG_0569 NC_008769.1 647644 648294 D thioredoxin protein 647644..648294 Mycobacterium bovis BCG str. Pasteur 1173P2 4696922 YP_976668.1 CDS ccdA NC_008769.1 648291 649070 D cytochrome c-type biogenesis protein ccdA 648291..649070 Mycobacterium bovis BCG str. Pasteur 1173P2 4696927 YP_976669.1 CDS BCG_0571 NC_008769.1 649103 650692 D hypothetical protein 649103..650692 Mycobacterium bovis BCG str. Pasteur 1173P2 4698483 YP_976670.1 CDS ccsA NC_008769.1 650689 651663 D cytochrome c-type biogenesis protein ccsA 650689..651663 Mycobacterium bovis BCG str. Pasteur 1173P2 4695986 YP_976671.1 CDS BCG_0573 NC_008769.1 651705 652922 D hypothetical protein 651705..652922 Mycobacterium bovis BCG str. Pasteur 1173P2 4695462 YP_976672.1 CDS BCG_0574 NC_008769.1 653127 653444 D hypothetical protein 653127..653444 Mycobacterium bovis BCG str. Pasteur 1173P2 4695929 YP_976673.1 CDS PE_PGRS6a NC_008769.1 653591 655336 D In Mycobacterium tuberculosis strain H37Rv, PE_PGRS6 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-t) splits PE_PGRS6 into 2 parts, PE_PGRS6a and PE_PGRS6b, resulting in PE_PGRS6a having a different COOH part. There is also a 84 bp and a 9 bp (*-cggggccgg) insertion in PE_PGRS6a; PE-PGRS family protein 653591..655336 Mycobacterium bovis BCG str. Pasteur 1173P2 4695964 YP_976674.1 CDS fabH NC_008769.1 655365 656372 R FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase complement(655365..656372) Mycobacterium bovis BCG str. Pasteur 1173P2 4696988 YP_976675.1 CDS menA NC_008769.1 656454 657332 R catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase complement(656454..657332) Mycobacterium bovis BCG str. Pasteur 1173P2 4697865 YP_976676.1 CDS pnp NC_008769.1 657349 658143 D Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate; 5'-methylthioadenosine phosphorylase 657349..658143 Mycobacterium bovis BCG str. Pasteur 1173P2 4696704 YP_976677.1 CDS galE3 NC_008769.1 658140 659180 D UDP-glucose 4-epimerase 658140..659180 Mycobacterium bovis BCG str. Pasteur 1173P2 4696816 YP_976678.1 CDS BCG_0581c NC_008769.1 659190 660623 R integral membrane protein complement(659190..660623) Mycobacterium bovis BCG str. Pasteur 1173P2 4695532 YP_976679.1 CDS BCG_0582 NC_008769.1 660932 662578 D Differs from Rv0538 by 1aa, P228R; hypothetical protein 660932..662578 Mycobacterium bovis BCG str. Pasteur 1173P2 4697755 YP_976680.1 CDS BCG_0583 NC_008769.1 662635 663267 D dolichyl-phosphate sugar synthase 662635..663267 Mycobacterium bovis BCG str. Pasteur 1173P2 4696938 YP_976681.1 CDS BCG_0584 NC_008769.1 663264 663926 D hypothetical protein 663264..663926 Mycobacterium bovis BCG str. Pasteur 1173P2 4696873 YP_976682.1 CDS BCG_0585c NC_008769.1 663947 665296 R Differs from Rv0541c by 1aa, V226I; integral membrane protein complement(663947..665296) Mycobacterium bovis BCG str. Pasteur 1173P2 4695636 YP_976683.1 CDS menE NC_008769.1 665308 666396 R O-succinylbenzoic acid--CoA ligase complement(665308..666396) Mycobacterium bovis BCG str. Pasteur 1173P2 4695870 YP_976684.1 CDS BCG_0587c NC_008769.1 666465 666767 R hypothetical protein complement(666465..666767) Mycobacterium bovis BCG str. Pasteur 1173P2 4696112 YP_976685.1 CDS BCG_0588c NC_008769.1 666827 667105 R hypothetical protein complement(666827..667105) Mycobacterium bovis BCG str. Pasteur 1173P2 4695966 YP_976686.1 CDS pitA NC_008769.1 667102 668355 R Differs from Rv0545c by 1aa, S49P; low-affinity inorganic phosphate transporter integral membrane protein pitA complement(667102..668355) Mycobacterium bovis BCG str. Pasteur 1173P2 4695987 YP_976687.1 CDS BCG_0590c NC_008769.1 668475 668861 R hypothetical protein complement(668475..668861) Mycobacterium bovis BCG str. Pasteur 1173P2 4699306 YP_976688.1 CDS BCG_0591c NC_008769.1 668924 669808 R short chain dehydrogenase complement(668924..669808) Mycobacterium bovis BCG str. Pasteur 1173P2 4697072 YP_976689.1 CDS menB NC_008769.1 669904 670848 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(669904..670848) Mycobacterium bovis BCG str. Pasteur 1173P2 4696042 YP_976690.1 CDS BCG_0594c NC_008769.1 671224 671532 R In Mycobacterium tuberculosis strain H37Rv, Rv0549c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv0549c into 2 parts; hypothetical protein complement(671224..671532) Mycobacterium bovis BCG str. Pasteur 1173P2 4695962 YP_976691.1 CDS BCG_0595c NC_008769.1 671529 671795 R hypothetical protein complement(671529..671795) Mycobacterium bovis BCG str. Pasteur 1173P2 4695985 YP_976692.1 CDS fadD8 NC_008769.1 671987 673702 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(671987..673702) Mycobacterium bovis BCG str. Pasteur 1173P2 4697045 YP_976693.1 CDS BCG_0597 NC_008769.1 673780 675384 D Differs from Rv0552 and Mb0567 by 1aa, T144I; hypothetical protein 673780..675384 Mycobacterium bovis BCG str. Pasteur 1173P2 4696275 YP_976694.1 CDS menC NC_008769.1 675381 676361 D catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 675381..676361 Mycobacterium bovis BCG str. Pasteur 1173P2 4696132 YP_976695.1 CDS bpoC NC_008769.1 676358 677146 D peroxidase bpoC 676358..677146 Mycobacterium bovis BCG str. Pasteur 1173P2 4696706 YP_976696.1 CDS menD NC_008769.1 677189 678853 D SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 677189..678853 Mycobacterium bovis BCG str. Pasteur 1173P2 4697151 YP_976697.1 CDS BCG_0601 NC_008769.1 678850 679365 D Differs from Rv0556 by 1aa, R15L; hypothetical protein 678850..679365 Mycobacterium bovis BCG str. Pasteur 1173P2 4696707 YP_976698.1 CDS pimB NC_008769.1 679427 680563 D mannosyltransferase 679427..680563 Mycobacterium bovis BCG str. Pasteur 1173P2 4696952 YP_976699.1 CDS ubiE NC_008769.1 680580 681284 D Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 680580..681284 Mycobacterium bovis BCG str. Pasteur 1173P2 4697040 YP_976700.1 CDS BCG_0604c NC_008769.1 681298 681636 R hypothetical protein complement(681298..681636) Mycobacterium bovis BCG str. Pasteur 1173P2 4696114 YP_976701.1 CDS BCG_0605c NC_008769.1 681670 682395 R benzoquinone methyltransferase complement(681670..682395) Mycobacterium bovis BCG str. Pasteur 1173P2 4696299 YP_976702.1 CDS BCG_0606c NC_008769.1 682420 683646 R oxidoreductase complement(682420..683646) Mycobacterium bovis BCG str. Pasteur 1173P2 4696472 YP_976703.1 CDS grcC1 NC_008769.1 683662 684669 D polyprenyl-diphosphate synthase grcC1 683662..684669 Mycobacterium bovis BCG str. Pasteur 1173P2 4696962 YP_976704.1 CDS htpX NC_008769.1 684770 685630 D metalloprotease; heat shock protein HtpX 684770..685630 Mycobacterium bovis BCG str. Pasteur 1173P2 4697844 YP_976705.1 CDS gpdA1 NC_008769.1 685815 686840 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(685815..686840) Mycobacterium bovis BCG str. Pasteur 1173P2 4696304 YP_976706.1 CDS BCG_0610c NC_008769.1 686901 688361 R monooxygenase complement(686901..688361) Mycobacterium bovis BCG str. Pasteur 1173P2 4697624 YP_976707.1 CDS BCG_0611c NC_008769.1 688439 688930 R nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein complement(688439..688930) Mycobacterium bovis BCG str. Pasteur 1173P2 4696458 YP_976708.1 CDS BCG_0612 NC_008769.1 689212 690231 D Differs from Rv0567 by 1aa, L201F; methyltransferase/methylase 689212..690231 Mycobacterium bovis BCG str. Pasteur 1173P2 4695654 YP_976709.1 CDS cyp135B1 NC_008769.1 690341 691759 D Differs from Rv0568 and Mb0583 by 1aa, E120G; cytochrome p450 135b1 cyp135B1 690341..691759 Mycobacterium bovis BCG str. Pasteur 1173P2 4695608 YP_976710.1 CDS BCG_0614 NC_008769.1 691894 692160 D hypothetical protein 691894..692160 Mycobacterium bovis BCG str. Pasteur 1173P2 4695493 YP_976711.1 CDS nrdZ NC_008769.1 692186 694318 D In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; ribonucleoside-diphosphate reductase large subunit nrdZ 692186..694318 Mycobacterium bovis BCG str. Pasteur 1173P2 4696396 YP_976712.1 CDS BCG_0616c NC_008769.1 694377 695708 R Differs from Rv0571c and Mb0586c by 1aa, L258F; hypothetical protein complement(694377..695708) Mycobacterium bovis BCG str. Pasteur 1173P2 4699182 YP_976713.1 CDS BCG_0617c NC_008769.1 695932 696273 R Differs from Rv0572c by 1aa, L31F; hypothetical protein complement(695932..696273) Mycobacterium bovis BCG str. Pasteur 1173P2 4696901 YP_976714.1 CDS BCG_0618c NC_008769.1 696741 698132 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(696741..698132) Mycobacterium bovis BCG str. Pasteur 1173P2 4696915 YP_976715.1 CDS BCG_0619c NC_008769.1 698142 699284 R Differs from Rv0574c by 1aa, K4N; hypothetical protein complement(698142..699284) Mycobacterium bovis BCG str. Pasteur 1173P2 4696026 YP_976716.1 CDS BCG_0620c NC_008769.1 699500 700636 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base insertion (*-c) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; hypothetical protein complement(699500..700636) Mycobacterium bovis BCG str. Pasteur 1173P2 4696312 YP_976717.1 CDS BCG_0621 NC_008769.1 700739 702043 D Differs from Rv0576 by 1aa, H233R; ArsR family transcriptional regulator 700739..702043 Mycobacterium bovis BCG str. Pasteur 1173P2 4695578 YP_976718.1 CDS TB27.3 NC_008769.1 702057 702842 D hypothetical protein 702057..702842 Mycobacterium bovis BCG str. Pasteur 1173P2 4696270 YP_976719.1 CDS PE_PGRS7 NC_008769.1 702887 706798 R Differs from Rv0578c and from Mb0593c by 3aa, there are deleted in Mycobacterium BCG bovis Pasteur; PE-PGRS family protein complement(702887..706798) Mycobacterium bovis BCG str. Pasteur 1173P2 4696422 YP_976720.1 CDS BCG_0624 NC_008769.1 707120 707878 D hypothetical protein 707120..707878 Mycobacterium bovis BCG str. Pasteur 1173P2 4696989 YP_976721.1 CDS BCG_0625c NC_008769.1 708007 708498 R hypothetical protein complement(708007..708498) Mycobacterium bovis BCG str. Pasteur 1173P2 4696982 YP_976722.1 CDS BCG_0626 NC_008769.1 708592 708807 D hypothetical protein 708592..708807 Mycobacterium bovis BCG str. Pasteur 1173P2 4696018 YP_976723.1 CDS BCG_0627 NC_008769.1 708804 709211 D hypothetical protein 708804..709211 Mycobacterium bovis BCG str. Pasteur 1173P2 4695993 YP_976724.1 CDS lpqN NC_008769.1 709271 709957 R lipoprotein lpqN complement(709271..709957) Mycobacterium bovis BCG str. Pasteur 1173P2 4695963 YP_976725.1 CDS BCG_0629 NC_008769.1 710111 712744 D Differs from Rv0584 by 1aa G90D; hypothetical protein 710111..712744 Mycobacterium bovis BCG str. Pasteur 1173P2 4698192 YP_976726.1 CDS BCG_0630c NC_008769.1 712767 715154 R Differs from Rv0585c by 1aa V438I and from Mb0600c by 2aa M150I and V438I; integral membrane protein complement(712767..715154) Mycobacterium bovis BCG str. Pasteur 1173P2 4695510 YP_976727.1 CDS BCG_0631 NC_008769.1 715292 716014 D GntR family transcriptional regulator 715292..716014 Mycobacterium bovis BCG str. Pasteur 1173P2 4696936 YP_976728.1 CDS yrbE2A NC_008769.1 716011 716808 D integral membrane protein YrbE2a 716011..716808 Mycobacterium bovis BCG str. Pasteur 1173P2 4697049 YP_976729.1 CDS yrbE2B NC_008769.1 716810 717697 D integral membrane protein YrbE2b 716810..717697 Mycobacterium bovis BCG str. Pasteur 1173P2 4697803 YP_976730.1 CDS mce2A NC_008769.1 717703 718917 D Differs from Rv0589 by 1aa S51F; mce-family protein mce2A 717703..718917 Mycobacterium bovis BCG str. Pasteur 1173P2 4695512 YP_976731.1 CDS mce2B NC_008769.1 718914 719945 D In Mycobacterium tuberculosis strain H37Rv, mce2B and Rv0590A are 2 genes, most likely to be linked. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, an in-frame insertion of a single base (*-g) leads to a single product; mce-family protein mce2B 718914..719945 Mycobacterium bovis BCG str. Pasteur 1173P2 4697200 YP_976732.1 CDS mce2C NC_008769.1 719942 721387 D Differs from Rv0591 by 2aa M49T and N398T; mce-family protein mce2C 719942..721387 Mycobacterium bovis BCG str. Pasteur 1173P2 4695884 YP_976733.1 CDS mce2Da NC_008769.1 721384 722934 D In Mycobacterium tuberculosis strain H37Rv, mce2D exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift occurs in a strech of C (7 for H37Rv, 8 for Mycobactrium bovis and 9 for Mycobacterium bovis BCG). This leads to mceDa genes with different COOH parts and a remnant mc2Db pseudogene; mce-family protein mce2Da 721384..722934 Mycobacterium bovis BCG str. Pasteur 1173P2 4695885 YP_976734.1 CDS lprL NC_008769.1 722909 724117 D In Mycobacterium bovis, a single base transition (c-t) introducing a stop codon, leads to the formation of a truncated product compared to its homolog in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur (188 aa versus 402 aa); mce family lipoprotein LprL 722909..724117 Mycobacterium bovis BCG str. Pasteur 1173P2 4695886 YP_976735.1 CDS mce2F NC_008769.1 724122 725672 D mce-family protein mce2F 724122..725672 Mycobacterium bovis BCG str. Pasteur 1173P2 4698589 YP_976736.1 CDS BCG_0641c NC_008769.1 725724 726116 R hypothetical protein complement(725724..726116) Mycobacterium bovis BCG str. Pasteur 1173P2 4695887 YP_976737.1 CDS BCG_0642c NC_008769.1 726113 726370 R hypothetical protein complement(726113..726370) Mycobacterium bovis BCG str. Pasteur 1173P2 4696945 YP_976738.1 CDS BCG_0643c NC_008769.1 726553 727788 R hypothetical protein complement(726553..727788) Mycobacterium bovis BCG str. Pasteur 1173P2 4695486 YP_976739.1 CDS BCG_0644c NC_008769.1 728039 728452 R hypothetical protein complement(728039..728452) Mycobacterium bovis BCG str. Pasteur 1173P2 4696934 YP_976740.1 CDS BCG_0645c NC_008769.1 728449 728685 R hypothetical protein complement(728449..728685) Mycobacterium bovis BCG str. Pasteur 1173P2 4696974 YP_976741.1 CDS BCG_0646c NC_008769.1 728789 729295 R two component sensor kinase complement(728789..729295) Mycobacterium bovis BCG str. Pasteur 1173P2 4696007 YP_976742.1 CDS BCG_0647c NC_008769.1 729409 729879 R two component sensor kinase (first part) complement(729409..729879) Mycobacterium bovis BCG str. Pasteur 1173P2 4696153 YP_976743.1 CDS tcrA NC_008769.1 729923 730684 R Differs from Rv0602c by 1aa I28V; two component DNA binding transcriptional regulatory protein tcrA complement(729923..730684) Mycobacterium bovis BCG str. Pasteur 1173P2 4696462 YP_976744.1 CDS BCG_0649 NC_008769.1 730741 731052 D Differs from Mb0619 by 2aa P77A and E96K; hypothetical protein 730741..731052 Mycobacterium bovis BCG str. Pasteur 1173P2 4696848 YP_976745.1 CDS lpqO NC_008769.1 731124 732074 D Differs from Rv0604 by 1aa P180S; lipoprotein lpqO 731124..732074 Mycobacterium bovis BCG str. Pasteur 1173P2 4696090 YP_976746.1 CDS BCG_0651 NC_008769.1 732291 732899 D resolvase 732291..732899 Mycobacterium bovis BCG str. Pasteur 1173P2 4698193 YP_976747.1 CDS BCG_0652 NC_008769.1 732901 733644 D transposase 732901..733644 Mycobacterium bovis BCG str. Pasteur 1173P2 4695563 YP_976748.1 CDS BCG_0653 NC_008769.1 733698 734084 D hypothetical protein 733698..734084 Mycobacterium bovis BCG str. Pasteur 1173P2 4696282 YP_976749.1 CDS BCG_0654 NC_008769.1 734129 734374 D hypothetical protein 734129..734374 Mycobacterium bovis BCG str. Pasteur 1173P2 4697062 YP_976750.1 CDS BCG_0655 NC_008769.1 734371 734772 D hypothetical protein 734371..734772 Mycobacterium bovis BCG str. Pasteur 1173P2 4696343 YP_976751.1 CDS BCG_0656 NC_008769.1 734715 734942 D hypothetical protein 734715..734942 Mycobacterium bovis BCG str. Pasteur 1173P2 4695546 YP_976752.1 CDS BCG_0657c NC_008769.1 735637 736794 R Differs from Rv0610c by 1aa S103N; hypothetical protein complement(735637..736794) Mycobacterium bovis BCG str. Pasteur 1173P2 4696366 YP_976753.1 CDS BCG_0658c NC_008769.1 736846 737229 R hypothetical protein complement(736846..737229) Mycobacterium bovis BCG str. Pasteur 1173P2 4696046 YP_976754.1 CDS BCG_0659 NC_008769.1 737209 737814 D hypothetical protein 737209..737814 Mycobacterium bovis BCG str. Pasteur 1173P2 4696003 YP_976755.1 CDS BCG_0660c NC_008769.1 737833 740400 R hypothetical protein complement(737833..740400) Mycobacterium bovis BCG str. Pasteur 1173P2 4696290 YP_976756.1 CDS BCG_0661 NC_008769.1 740241 741233 D hypothetical protein 740241..741233 Mycobacterium bovis BCG str. Pasteur 1173P2 4696919 YP_976757.1 CDS BCG_0662 NC_008769.1 741230 741472 D integral membrane protein 741230..741472 Mycobacterium bovis BCG str. Pasteur 1173P2 4696000 YP_976758.1 CDS BCG_0663c NC_008769.1 741469 741735 R hypothetical protein complement(741469..741735) Mycobacterium bovis BCG str. Pasteur 1173P2 4695417 YP_976759.1 CDS BCG_0663A NC_008769.1 741667 741894 D antitoxin 741667..741894 Mycobacterium bovis BCG str. Pasteur 1173P2 4696968 YP_976760.1 CDS BCG_0664 NC_008769.1 741891 742292 D hypothetical protein 741891..742292 Mycobacterium bovis BCG str. Pasteur 1173P2 4697085 YP_976761.1 CDS galT NC_008769.1 742421 743605 D In Mycobacterium tuberculosis strain H37Rv, galT is split into 2 parts, galT' and 'galT. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, an in-frame insertion of a single base (*-a) leads to a single product.Differs from Mb0635 by 1aa R183G and from Rv0619 by 1aa A397T; galactose-1-phosphate uridylyltransferase galT 742421..743605 Mycobacterium bovis BCG str. Pasteur 1173P2 4696022 YP_976762.1 CDS galK NC_008769.1 743602 744693 D catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 743602..744693 Mycobacterium bovis BCG str. Pasteur 1173P2 4695534 YP_976763.1 CDS BCG_0667 NC_008769.1 745088 746245 D In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a single base transition (a-g) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (385 aa versus 354 aa); hypothetical protein 745088..746245 Mycobacterium bovis BCG str. Pasteur 1173P2 4695533 YP_976764.1 CDS BCG_0668 NC_008769.1 746256 747203 D hypothetical protein 746256..747203 Mycobacterium bovis BCG str. Pasteur 1173P2 4696976 YP_976765.1 CDS BCG_0669 NC_008769.1 747296 747550 D hypothetical protein 747296..747550 Mycobacterium bovis BCG str. Pasteur 1173P2 4696463 YP_976766.1 CDS BCG_0670 NC_008769.1 747550 747945 D hypothetical protein 747550..747945 Mycobacterium bovis BCG str. Pasteur 1173P2 4696931 YP_976767.1 CDS BCG_0671c NC_008769.1 748039 748779 R hypothetical protein complement(748039..748779) Mycobacterium bovis BCG str. Pasteur 1173P2 4696911 YP_976768.1 CDS BCG_0672 NC_008769.1 748911 749171 D hypothetical protein 748911..749171 Mycobacterium bovis BCG str. Pasteur 1173P2 4697142 YP_976769.1 CDS BCG_0673 NC_008769.1 749168 749575 D hypothetical protein 749168..749575 Mycobacterium bovis BCG str. Pasteur 1173P2 4696928 YP_976770.1 CDS BCG_0674c NC_008769.1 749647 750798 R hypothetical protein complement(749647..750798) Mycobacterium bovis BCG str. Pasteur 1173P2 4697437 YP_976771.1 CDS recD NC_008769.1 750891 752618 R Differs from Rv0629c by 1aa A536T; exonuclease V (alpha chain) recD complement(750891..752618) Mycobacterium bovis BCG str. Pasteur 1173P2 4697372 YP_976772.1 CDS recBa NC_008769.1 753205 755898 R In Mycobacterium tuberculosis strain H37Rv, recB exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (g-*) splits recB into 2 parts, recBa and recBb. Differs from Mb0647c by 1aa H514R and from Rv0630c by 3aa L74V, H514R and F811V; exonuclease V subunit beta recBa complement(753205..755898) Mycobacterium bovis BCG str. Pasteur 1173P2 4696079 YP_976773.1 CDS recC NC_008769.1 755898 759191 R Differs from Rv0631c by 1aa E329G and from Mb0648c by 1aa P858L; exonuclease V (gamma chain) recC complement(755898..759191) Mycobacterium bovis BCG str. Pasteur 1173P2 4697310 YP_976774.1 CDS echA3 NC_008769.1 759468 760163 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(759468..760163) Mycobacterium bovis BCG str. Pasteur 1173P2 4696080 YP_976775.1 CDS BCG_0680c NC_008769.1 760212 761042 R In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 9 bp deletion (cgggtgcgc-*) leads to shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (276 aa versus 279 aa); hypothetical protein complement(760212..761042) Mycobacterium bovis BCG str. Pasteur 1173P2 4699210 YP_976776.1 CDS BCG_0681c NC_008769.1 761196 761909 R glyoxalase II complement(761196..761909) Mycobacterium bovis BCG str. Pasteur 1173P2 4697168 YP_976777.1 CDS BCG_0682 NC_008769.1 761989 762240 D hypothetical protein 761989..762240 Mycobacterium bovis BCG str. Pasteur 1173P2 4697369 YP_976778.1 CDS rpmG NC_008769.1 762588 762755 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 762588..762755 Mycobacterium bovis BCG str. Pasteur 1173P2 4697284 YP_976779.1 CDS BCG_0684 NC_008769.1 762806 763282 D functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadA 762806..763282 Mycobacterium bovis BCG str. Pasteur 1173P2 4695798 YP_976780.1 CDS BCG_0685 NC_008769.1 763269 763697 D functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadB 763269..763697 Mycobacterium bovis BCG str. Pasteur 1173P2 4697374 YP_976781.1 CDS BCG_0686 NC_008769.1 763701 764201 D functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadC 763701..764201 Mycobacterium bovis BCG str. Pasteur 1173P2 4697376 YP_976782.1 CDS secE NC_008769.1 764613 765098 D forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 764613..765098 Mycobacterium bovis BCG str. Pasteur 1173P2 4695653 YP_976783.1 CDS nusG NC_008769.1 765130 765846 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 765130..765846 Mycobacterium bovis BCG str. Pasteur 1173P2 4697707 YP_976784.1 CDS rplK NC_008769.1 765898 766326 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 765898..766326 Mycobacterium bovis BCG str. Pasteur 1173P2 4696323 YP_976785.1 CDS rplA NC_008769.1 766393 767100 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 766393..767100 Mycobacterium bovis BCG str. Pasteur 1173P2 4695926 YP_976786.1 CDS mmaA4 NC_008769.1 767174 768079 R Differs from Rv0642c by 1aa L95F; methoxy mycolic acid synthase complement(767174..768079) Mycobacterium bovis BCG str. Pasteur 1173P2 4699114 YP_976787.1 CDS mmaA3 NC_008769.1 768144 769025 R methoxy mycolic acid synthase complement(768144..769025) Mycobacterium bovis BCG str. Pasteur 1173P2 4697159 YP_976788.1 CDS mmaA2 NC_008769.1 769173 770036 R differs from Rv0644c by 1aa L114R; methoxy mycolic acid synthase complement(769173..770036) Mycobacterium bovis BCG str. Pasteur 1173P2 4697158 YP_976789.1 CDS mmaA1 NC_008769.1 770203 771063 R methoxy mycolic acid synthase complement(770203..771063) Mycobacterium bovis BCG str. Pasteur 1173P2 4697157 YP_976790.1 CDS lipG NC_008769.1 771110 772015 R lipase/esterase lipG complement(771110..772015) Mycobacterium bovis BCG str. Pasteur 1173P2 4697156 YP_976791.1 CDS BCG_0696c NC_008769.1 772027 773493 R Differs from Rv0647c by 1aa T293A; hypothetical protein complement(772027..773493) Mycobacterium bovis BCG str. Pasteur 1173P2 4698086 YP_976792.1 CDS BCG_0697 NC_008769.1 773579 777775 D Differs from Rv0648 by 1aa L200S; alpha-mannosidase 773579..777775 Mycobacterium bovis BCG str. Pasteur 1173P2 4697362 YP_976793.1 CDS fabD2 NC_008769.1 777772 778446 D malonyl CoA-ACP transacylase 777772..778446 Mycobacterium bovis BCG str. Pasteur 1173P2 4697502 YP_976794.1 CDS BCG_0699 NC_008769.1 778446 779354 D sugar kinase 778446..779354 Mycobacterium bovis BCG str. Pasteur 1173P2 4698482 YP_976795.1 CDS rplJ NC_008769.1 779685 780221 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 779685..780221 Mycobacterium bovis BCG str. Pasteur 1173P2 4697518 YP_976796.1 CDS rplL NC_008769.1 780258 780650 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 780258..780650 Mycobacterium bovis BCG str. Pasteur 1173P2 4695925 YP_976797.1 CDS BCG_0702c NC_008769.1 780643 781338 R TetR family transcriptional regulator complement(780643..781338) Mycobacterium bovis BCG str. Pasteur 1173P2 4695927 YP_976798.1 CDS BCG_0703 NC_008769.1 781409 782914 D dioxygenase 781409..782914 Mycobacterium bovis BCG str. Pasteur 1173P2 4697453 YP_976799.1 CDS mkl NC_008769.1 782926 784005 D ribonucleotide-transport ATP-binding protein ABC transporter mkl 782926..784005 Mycobacterium bovis BCG str. Pasteur 1173P2 4697537 YP_976800.1 CDS BCG_0705c NC_008769.1 784393 784776 R hypothetical protein complement(784393..784776) Mycobacterium bovis BCG str. Pasteur 1173P2 4697155 YP_976801.1 CDS BCG_0706c NC_008769.1 784871 785026 R hypothetical protein complement(784871..785026) Mycobacterium bovis BCG str. Pasteur 1173P2 4697506 YP_976802.1 CDS BCG_0707c NC_008769.1 785102 785818 R Differs from Rv0658c by 1aa P75L; integral membrane protein complement(785102..785818) Mycobacterium bovis BCG str. Pasteur 1173P2 4697499 YP_976803.1 CDS BCG_0708c NC_008769.1 786094 786402 R hypothetical protein complement(786094..786402) Mycobacterium bovis BCG str. Pasteur 1173P2 4697661 YP_976804.1 CDS BCG_0709c NC_008769.1 786389 786634 R hypothetical protein complement(786389..786634) Mycobacterium bovis BCG str. Pasteur 1173P2 4698808 YP_976805.1 CDS BCG_0710c NC_008769.1 786744 787181 R hypothetical protein complement(786744..787181) Mycobacterium bovis BCG str. Pasteur 1173P2 4697573 YP_976806.1 CDS BCG_0711c NC_008769.1 787178 787546 R hypothetical protein complement(787178..787546) Mycobacterium bovis BCG str. Pasteur 1173P2 4697866 YP_976807.1 CDS atsD NC_008769.1 787546 789909 D Differs from Rv0663 by 1aa G349D; arylsulfatase atsD 787546..789909 Mycobacterium bovis BCG str. Pasteur 1173P2 4697741 YP_976808.1 CDS BCG_0713 NC_008769.1 789941 790213 D hypothetical protein 789941..790213 Mycobacterium bovis BCG str. Pasteur 1173P2 4696184 YP_976809.1 CDS BCG_0714 NC_008769.1 790210 790548 D hypothetical protein 790210..790548 Mycobacterium bovis BCG str. Pasteur 1173P2 4697901 YP_976810.1 CDS BCG_0715 NC_008769.1 790545 790718 D hypothetical protein 790545..790718 Mycobacterium bovis BCG str. Pasteur 1173P2 4697718 YP_976811.1 CDS rpoB NC_008769.1 791216 794734 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 791216..794734 Mycobacterium bovis BCG str. Pasteur 1173P2 4697686 YP_976812.1 CDS rpoC NC_008769.1 794779 798729 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 794779..798729 Mycobacterium bovis BCG str. Pasteur 1173P2 4696375 YP_976813.1 CDS BCG_0718c NC_008769.1 799093 801006 R Differs from Rv0669c by 1aa P146S; hydrolase complement(799093..801006) Mycobacterium bovis BCG str. Pasteur 1173P2 4696376 YP_976814.1 CDS end NC_008769.1 801201 801959 D Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 801201..801959 Mycobacterium bovis BCG str. Pasteur 1173P2 4697867 YP_976815.1 CDS lpqP NC_008769.1 801991 802833 D lipoprotein lpqP 801991..802833 Mycobacterium bovis BCG str. Pasteur 1173P2 4697930 YP_976816.1 CDS fadE8 NC_008769.1 802893 804521 D acyl-CoA dehydrogenase fadE8 802893..804521 Mycobacterium bovis BCG str. Pasteur 1173P2 4698194 YP_976817.1 CDS echA4 NC_008769.1 804532 805470 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 804532..805470 Mycobacterium bovis BCG str. Pasteur 1173P2 4696259 YP_976818.1 CDS BCG_0723 NC_008769.1 805473 806195 D hypothetical protein 805473..806195 Mycobacterium bovis BCG str. Pasteur 1173P2 4696014 YP_976819.1 CDS echA5 NC_008769.1 806192 806983 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 806192..806983 Mycobacterium bovis BCG str. Pasteur 1173P2 4697642 YP_976820.1 CDS mmpL5 NC_008769.1 806995 809889 R Differs from Rv0676c by 2aa I793T and V948I; transmembrane transport protein mmpL5 complement(806995..809889) Mycobacterium bovis BCG str. Pasteur 1173P2 4699064 YP_976821.1 CDS mmpS5 NC_008769.1 809886 810314 R membrane protein mmpS5 complement(809886..810314) Mycobacterium bovis BCG str. Pasteur 1173P2 4696171 YP_976822.1 CDS BCG_0727 NC_008769.1 810399 810896 D hypothetical protein 810399..810896 Mycobacterium bovis BCG str. Pasteur 1173P2 4697597 YP_976823.1 CDS BCG_0728c NC_008769.1 810952 811449 R hypothetical protein complement(810952..811449) Mycobacterium bovis BCG str. Pasteur 1173P2 4697592 YP_976824.1 CDS BCG_0729c NC_008769.1 811451 811825 R hypothetical protein complement(811451..811825) Mycobacterium bovis BCG str. Pasteur 1173P2 4697660 YP_976825.1 CDS BCG_0730 NC_008769.1 812130 812720 D TetR family transcriptional regulator 812130..812720 Mycobacterium bovis BCG str. Pasteur 1173P2 4697510 YP_976826.1 CDS rpsL NC_008769.1 812969 813343 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 812969..813343 Mycobacterium bovis BCG str. Pasteur 1173P2 4697532 YP_976827.1 CDS rpsG NC_008769.1 813343 813813 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 813343..813813 Mycobacterium bovis BCG str. Pasteur 1173P2 4698849 YP_976828.1 CDS fusA1 NC_008769.1 813894 815999 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 813894..815999 Mycobacterium bovis BCG str. Pasteur 1173P2 4695754 YP_976829.1 CDS tuf NC_008769.1 816230 817420 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 816230..817420 Mycobacterium bovis BCG str. Pasteur 1173P2 4695506 YP_976830.1 CDS BCG_0735 NC_008769.1 817558 818355 D Differs from Rv0686 by 1aa S82I; hypothetical protein 817558..818355 Mycobacterium bovis BCG str. Pasteur 1173P2 4697091 YP_976831.1 CDS fabG NC_008769.1 818508 819335 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 818508..819335 Mycobacterium bovis BCG str. Pasteur 1173P2 4697582 YP_976832.1 CDS BCG_0737 NC_008769.1 819349 820569 D ferredoxin reductase 819349..820569 Mycobacterium bovis BCG str. Pasteur 1173P2 4697782 YP_976833.1 CDS BCG_0738c NC_008769.1 820566 820820 R hypothetical protein complement(820566..820820) Mycobacterium bovis BCG str. Pasteur 1173P2 4697242 YP_976834.1 CDS BCG_0739c NC_008769.1 821433 822482 R hypothetical protein complement(821433..822482) Mycobacterium bovis BCG str. Pasteur 1173P2 4697439 YP_976835.1 CDS BCG_0740c NC_008769.1 822479 823075 R transcriptional regulatory protein complement(822479..823075) Mycobacterium bovis BCG str. Pasteur 1173P2 4697209 YP_976836.1 CDS BCG_0741 NC_008769.1 823240 823569 D hypothetical protein 823240..823569 Mycobacterium bovis BCG str. Pasteur 1173P2 4697163 YP_976837.1 CDS pqqE NC_008769.1 823566 824741 D coenzyme PQQ synthesis protein E pqqE 823566..824741 Mycobacterium bovis BCG str. Pasteur 1173P2 4697233 YP_976838.1 CDS lldD1 NC_008769.1 824744 825934 D L-lactate dehydrogenase (cytochrome) lldD1 824744..825934 Mycobacterium bovis BCG str. Pasteur 1173P2 4696489 YP_976839.1 CDS BCG_0744 NC_008769.1 826124 826879 D hypothetical protein 826124..826879 Mycobacterium bovis BCG str. Pasteur 1173P2 4695785 YP_976840.1 CDS BCG_0745 NC_008769.1 826928 828340 D membrane sugar transferase 826928..828340 Mycobacterium bovis BCG str. Pasteur 1173P2 4697153 YP_976841.1 CDS BCG_0746 NC_008769.1 828342 829781 D dehydrogenase 828342..829781 Mycobacterium bovis BCG str. Pasteur 1173P2 4697170 YP_976842.1 CDS BCG_0747 NC_008769.1 830242 830571 D In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718; hypothetical protein 830242..830571 Mycobacterium bovis BCG str. Pasteur 1173P2 4697137 YP_976843.1 CDS BCG_0748 NC_008769.1 830619 830852 D In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718; hypothetical protein 830619..830852 Mycobacterium bovis BCG str. Pasteur 1173P2 4697106 YP_976844.1 CDS BCG_0749 NC_008769.1 831037 831258 D hypothetical protein 831037..831258 Mycobacterium bovis BCG str. Pasteur 1173P2 4697055 YP_976845.1 CDS rpsJ NC_008769.1 831895 832200 D NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 831895..832200 Mycobacterium bovis BCG str. Pasteur 1173P2 4697101 YP_976846.1 CDS rplC NC_008769.1 832217 832870 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 832217..832870 Mycobacterium bovis BCG str. Pasteur 1173P2 4695757 YP_976847.1 CDS rplD NC_008769.1 832870 833541 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 832870..833541 Mycobacterium bovis BCG str. Pasteur 1173P2 4695852 YP_976848.1 CDS rplW NC_008769.1 833541 833843 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 833541..833843 Mycobacterium bovis BCG str. Pasteur 1173P2 4695853 YP_976849.1 CDS rplB NC_008769.1 833990 834832 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 833990..834832 Mycobacterium bovis BCG str. Pasteur 1173P2 4695883 YP_976850.1 CDS rpsS NC_008769.1 834873 835154 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 834873..835154 Mycobacterium bovis BCG str. Pasteur 1173P2 4695851 YP_976851.1 CDS rplV NC_008769.1 835151 835744 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 835151..835744 Mycobacterium bovis BCG str. Pasteur 1173P2 4695809 YP_976852.1 CDS rpsC NC_008769.1 835744 836568 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 835744..836568 Mycobacterium bovis BCG str. Pasteur 1173P2 4695882 YP_976853.1 CDS rplP NC_008769.1 836572 836988 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 836572..836988 Mycobacterium bovis BCG str. Pasteur 1173P2 4697297 YP_976854.1 CDS rpmC NC_008769.1 836988 837221 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 836988..837221 Mycobacterium bovis BCG str. Pasteur 1173P2 4695891 YP_976855.1 CDS rpsQ NC_008769.1 837218 837628 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 837218..837628 Mycobacterium bovis BCG str. Pasteur 1173P2 4696783 YP_976856.1 CDS atsA NC_008769.1 837797 840160 D In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur, atsA exists as a single gene. In Mycobacterium bovis, a single base transversion (g-t), introducing a stop codon, splits atsA into 2 parts, atsAa and atsAb; arylsulfatase atsA 837797..840160 Mycobacterium bovis BCG str. Pasteur 1173P2 4695806 YP_976857.1 CDS BCG_0762 NC_008769.1 840208 841107 D hypothetical protein 840208..841107 Mycobacterium bovis BCG str. Pasteur 1173P2 4696242 YP_976858.1 CDS BCG_0763 NC_008769.1 841408 842349 D hypothetical protein 841408..842349 Mycobacterium bovis BCG str. Pasteur 1173P2 4697057 YP_976859.1 CDS rplN NC_008769.1 842836 843204 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 842836..843204 Mycobacterium bovis BCG str. Pasteur 1173P2 4696977 YP_976860.1 CDS rplX NC_008769.1 843205 843522 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 843205..843522 Mycobacterium bovis BCG str. Pasteur 1173P2 4695889 YP_976861.1 CDS rplE NC_008769.1 843522 844085 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 843522..844085 Mycobacterium bovis BCG str. Pasteur 1173P2 4697626 YP_976862.1 CDS rpsN NC_008769.1 844090 844275 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 844090..844275 Mycobacterium bovis BCG str. Pasteur 1173P2 4695854 YP_976863.1 CDS rpsH NC_008769.1 844439 844837 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 844439..844837 Mycobacterium bovis BCG str. Pasteur 1173P2 4698851 YP_976864.1 CDS rplF NC_008769.1 844861 845400 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 844861..845400 Mycobacterium bovis BCG str. Pasteur 1173P2 4695755 YP_976865.1 CDS rplR NC_008769.1 845403 845771 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 845403..845771 Mycobacterium bovis BCG str. Pasteur 1173P2 4695855 YP_976866.1 CDS rpsE NC_008769.1 845791 846453 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 845791..846453 Mycobacterium bovis BCG str. Pasteur 1173P2 4695893 YP_976867.1 CDS rpmD NC_008769.1 846456 846653 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 846456..846653 Mycobacterium bovis BCG str. Pasteur 1173P2 4697299 YP_976868.1 CDS rplO NC_008769.1 846653 847093 D late assembly protein; 50S ribosomal protein L15 846653..847093 Mycobacterium bovis BCG str. Pasteur 1173P2 4696784 YP_976869.1 CDS sppA NC_008769.1 847126 848997 D protease IV sppA (endopeptidase IV) 847126..848997 Mycobacterium bovis BCG str. Pasteur 1173P2 4695890 YP_976870.1 CDS BCG_0775c NC_008769.1 849002 849907 R hypothetical protein complement(849002..849907) Mycobacterium bovis BCG str. Pasteur 1173P2 4695624 YP_976871.1 CDS BCG_0776c NC_008769.1 850000 851103 R hypothetical protein complement(850000..851103) Mycobacterium bovis BCG str. Pasteur 1173P2 4696874 YP_976872.1 CDS fucA NC_008769.1 851306 851962 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(851306..851962) Mycobacterium bovis BCG str. Pasteur 1173P2 4696764 YP_976873.1 CDS serA2 NC_008769.1 851959 852939 R Differs from Rv0728c by 1aa H242R; D-3-phosphoglycerate dehydrogenase serA2 complement(851959..852939) Mycobacterium bovis BCG str. Pasteur 1173P2 4698536 YP_976874.1 CDS xylB NC_008769.1 852970 854316 D Differs from Rv0729 by 2aa P134L and S439; d-xylulose kinase xylB 852970..854316 Mycobacterium bovis BCG str. Pasteur 1173P2 4697884 YP_976875.1 CDS BCG_0780 NC_008769.1 854329 855057 D hypothetical protein 854329..855057 Mycobacterium bovis BCG str. Pasteur 1173P2 4697558 YP_976876.1 CDS BCG_0781c NC_008769.1 855146 856102 R hypothetical protein complement(855146..856102) Mycobacterium bovis BCG str. Pasteur 1173P2 4696695 YP_976877.1 CDS secY NC_008769.1 856263 857588 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 856263..857588 Mycobacterium bovis BCG str. Pasteur 1173P2 4696747 YP_976878.1 CDS adk NC_008769.1 857585 858130 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 857585..858130 Mycobacterium bovis BCG str. Pasteur 1173P2 4697881 YP_976879.1 CDS mapA NC_008769.1 858133 858933 D catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 858133..858933 Mycobacterium bovis BCG str. Pasteur 1173P2 4697641 YP_976880.1 CDS sigL NC_008769.1 859006 859539 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein regulates polyketide synthases and secreted or membrane proteins; RNA polymerase sigma factor SigL 859006..859539 Mycobacterium bovis BCG str. Pasteur 1173P2 4698661 YP_976881.1 CDS BCG_0786 NC_008769.1 859603 860355 D hypothetical protein 859603..860355 Mycobacterium bovis BCG str. Pasteur 1173P2 4696444 YP_976882.1 CDS BCG_0787 NC_008769.1 860670 861167 D transcriptional regulatory protein 860670..861167 Mycobacterium bovis BCG str. Pasteur 1173P2 4696686 YP_976883.1 CDS BCG_0788 NC_008769.1 861525 862073 D hypothetical protein 861525..862073 Mycobacterium bovis BCG str. Pasteur 1173P2 4696739 YP_976884.1 CDS BCG_0789 NC_008769.1 862278 863126 D In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 2 bp insertion (*-cg) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (282 aa versus 268 aa); hypothetical protein 862278..863126 Mycobacterium bovis BCG str. Pasteur 1173P2 4696722 YP_976885.1 CDS BCG_0790 NC_008769.1 863241 863768 D hypothetical protein 863241..863768 Mycobacterium bovis BCG str. Pasteur 1173P2 4696593 YP_976886.1 CDS BCG_0791 NC_008769.1 863999 864313 D transposase 863999..864313 Mycobacterium bovis BCG str. Pasteur 1173P2 4696620 YP_976887.1 CDS PE_PGRS8 NC_008769.1 864455 864973 D PE-PGRS family protein 864455..864973 Mycobacterium bovis BCG str. Pasteur 1173P2 4696650 YP_976888.1 CDS BCG_0793c NC_008769.1 865351 865908 R hypothetical protein complement(865351..865908) Mycobacterium bovis BCG str. Pasteur 1173P2 4696990 YP_976889.1 CDS BCG_0794c NC_008769.1 865905 866411 R transcriptional regulatory protein complement(865905..866411) Mycobacterium bovis BCG str. Pasteur 1173P2 4696559 YP_976890.1 CDS BCG_0795 NC_008769.1 866619 867146 D hypothetical protein 866619..867146 Mycobacterium bovis BCG str. Pasteur 1173P2 4696566 YP_976891.1 CDS PE_PGRS9 NC_008769.1 867166 869559 D In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, two 48 bp deletions, and a 138 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (797 aa versus 783 aa). Differs from Mb0767 by 1aa S597N; PE-PGRS family protein 867166..869559 Mycobacterium bovis BCG str. Pasteur 1173P2 4696604 YP_976892.1 CDS PE_PGRS10 NC_008769.1 869958 872639 D In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, insertions of 168 bp and 105 bp, a 11 bp for 71 bp substitution, and a 9 bp deletion (cggcaacgg-*), leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (909 aa and 893 aa versus 801 aa). In addition, in Mycobacterium bovis BCG Pasteur, a 48 bp deletion compared to Mycobacterium bovis and Mycobacterium tuberculosis strain H37Rv occurs; PE-PGRS family protein 869958..872639 Mycobacterium bovis BCG str. Pasteur 1173P2 4696991 YP_976893.1 CDS BCG_0798 NC_008769.1 872730 872987 D hypothetical protein 872730..872987 Mycobacterium bovis BCG str. Pasteur 1173P2 4696297 YP_976894.1 CDS BCG_0799 NC_008769.1 873011 873439 D hypothetical protein 873011..873439 Mycobacterium bovis BCG str. Pasteur 1173P2 4696806 YP_976895.1 CDS BCG_0800c NC_008769.1 873520 873657 R hypothetical protein complement(873520..873657) Mycobacterium bovis BCG str. Pasteur 1173P2 4696430 YP_976896.1 CDS BCG_0801 NC_008769.1 873816 874061 D hypothetical protein 873816..874061 Mycobacterium bovis BCG str. Pasteur 1173P2 4696385 YP_976897.1 CDS mmsB NC_008769.1 874130 875014 R 3-hydroxyisobutyrate dehydrogenase complement(874130..875014) Mycobacterium bovis BCG str. Pasteur 1173P2 4696283 YP_976898.1 CDS fadE9 NC_008769.1 875025 876197 R Differs from Rv0752c by 2aa A69V and V186I; acyl-CoA dehydrogenase fadE9 complement(875025..876197) Mycobacterium bovis BCG str. Pasteur 1173P2 4697601 YP_976899.1 CDS mmsA NC_008769.1 876204 877736 R Differs from Mb0775c by 1aa V442G; methylmalonate-semialdehyde dehydrogenase mmsA complement(876204..877736) Mycobacterium bovis BCG str. Pasteur 1173P2 4695680 YP_976900.1 CDS PE_PGRS11 NC_008769.1 877942 879696 D PE-PGRS family protein 877942..879696 Mycobacterium bovis BCG str. Pasteur 1173P2 4697600 YP_976901.1 CDS PPE12 NC_008769.1 879886 881823 R Differs from Rv0755c by 1aa K545R; PPE family protein complement(879886..881823) Mycobacterium bovis BCG str. Pasteur 1173P2 4697794 YP_976902.1 CDS BCG_0807c NC_008769.1 882125 882310 R transposase complement(882125..882310) Mycobacterium bovis BCG str. Pasteur 1173P2 4696163 YP_976903.1 CDS BCG_0808c NC_008769.1 882524 883249 R hypothetical protein complement(882524..883249) Mycobacterium bovis BCG str. Pasteur 1173P2 4695652 YP_976904.1 CDS phoP NC_008769.1 883391 884134 D two component system response transcriptional positive regulator phoP 883391..884134 Mycobacterium bovis BCG str. Pasteur 1173P2 4696141 YP_976905.1 CDS phoR NC_008769.1 884179 885636 D Differs from Rv0755c by 2aa I71G, L172P; two component system response sensor kinase membrane associated phoR 884179..885636 Mycobacterium bovis BCG str. Pasteur 1173P2 4697587 YP_976906.1 CDS BCG_0811c NC_008769.1 885608 885940 R hypothetical protein complement(885608..885940) Mycobacterium bovis BCG str. Pasteur 1173P2 4698178 YP_976907.1 CDS BCG_0812c NC_008769.1 886049 886468 R hypothetical protein complement(886049..886468) Mycobacterium bovis BCG str. Pasteur 1173P2 4696971 YP_976908.1 CDS adhB NC_008769.1 886481 887608 R zinc-containing alcohol dehydrogenaseAdhB complement(886481..887608) Mycobacterium bovis BCG str. Pasteur 1173P2 4697429 YP_976909.1 CDS BCG_0814c NC_008769.1 887707 888252 R hypothetical protein complement(887707..888252) Mycobacterium bovis BCG str. Pasteur 1173P2 4697504 YP_976910.1 CDS BCG_0815c NC_008769.1 888255 888461 R ferredoxin complement(888255..888461) Mycobacterium bovis BCG str. Pasteur 1173P2 4697751 YP_976911.1 CDS cyp51 NC_008769.1 888464 889819 R cytochrome P450 51 cyp51 complement(888464..889819) Mycobacterium bovis BCG str. Pasteur 1173P2 4696762 YP_976912.1 CDS BCG_0817c NC_008769.1 889819 890646 R short chain dehydrogenase complement(889819..890646) Mycobacterium bovis BCG str. Pasteur 1173P2 4696288 YP_976913.1 CDS cyp123 NC_008769.1 890228 891853 R cytochrome P450 123 cyp123 complement(890228..891853) Mycobacterium bovis BCG str. Pasteur 1173P2 4696040 YP_976914.1 CDS BCG_0819c NC_008769.1 891850 892491 R hypothetical protein complement(891850..892491) Mycobacterium bovis BCG str. Pasteur 1173P2 4696899 YP_976915.1 CDS aldA NC_008769.1 892693 894162 D aldehyde dehydrogenase AldA 892693..894162 Mycobacterium bovis BCG str. Pasteur 1173P2 4695983 YP_976916.1 CDS BCG_0821 NC_008769.1 894193 894939 D Differs from Rv0769 by 1aa V55A; short chain dehydrogenase 894193..894939 Mycobacterium bovis BCG str. Pasteur 1173P2 4698993 YP_976917.1 CDS BCG_0822 NC_008769.1 895037 895924 D Differs from Mb0793 by 1aa V126G; dehydrogenase/reductase 895037..895924 Mycobacterium bovis BCG str. Pasteur 1173P2 4697056 YP_976918.1 CDS BCG_0823 NC_008769.1 895921 896355 D 4-carboxymuconolactone decarboxylase 895921..896355 Mycobacterium bovis BCG str. Pasteur 1173P2 4696023 YP_976919.1 CDS purD NC_008769.1 896367 897635 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 896367..897635 Mycobacterium bovis BCG str. Pasteur 1173P2 4697643 YP_976920.1 CDS ggtA NC_008769.1 897632 899170 R bifunctional acylase ggtA: cephalosporin acylase + gamma-glutamyltranspeptidase complement(897632..899170) Mycobacterium bovis BCG str. Pasteur 1173P2 4699228 YP_976921.1 CDS BCG_0826c NC_008769.1 899221 900132 R Differs from Rv0774c by 1aa A219S and from Mb0797c by 1aa D142A; hypothetical protein complement(899221..900132) Mycobacterium bovis BCG str. Pasteur 1173P2 4698647 YP_976922.1 CDS BCG_0827 NC_008769.1 900188 900811 D hypothetical protein 900188..900811 Mycobacterium bovis BCG str. Pasteur 1173P2 4696235 YP_976923.1 CDS BCG_0828c NC_008769.1 900765 901544 R hypothetical protein complement(900765..901544) Mycobacterium bovis BCG str. Pasteur 1173P2 4696460 YP_976924.1 CDS purB NC_008769.1 901789 903207 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 901789..903207 Mycobacterium bovis BCG str. Pasteur 1173P2 4696978 YP_976925.1 CDS cyp126 NC_008769.1 903212 904456 D cytochrome P450 126 cyp126 903212..904456 Mycobacterium bovis BCG str. Pasteur 1173P2 4699226 YP_976926.1 CDS BCG_0831c NC_008769.1 904453 905073 R hypothetical protein complement(904453..905073) Mycobacterium bovis BCG str. Pasteur 1173P2 4695594 YP_976927.1 CDS purC NC_008769.1 905124 906017 D catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 905124..906017 Mycobacterium bovis BCG str. Pasteur 1173P2 4696944 YP_976928.1 CDS ptrB NC_008769.1 906014 908173 D In Mycobacterium tuberculosis strain H37Rv, ptrB is split into 2 genes, ptrBa and ptrBb, due to a frameshift. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 2 bp insertion (*-gc) leads to a single product; protease II ptrB (oligopeptidase B) 906014..908173 Mycobacterium bovis BCG str. Pasteur 1173P2 4699227 YP_976929.1 CDS emrB NC_008769.1 908601 910223 R multidrug resistance integral membrane efflux protein emrB complement(908601..910223) Mycobacterium bovis BCG str. Pasteur 1173P2 4699224 YP_976930.1 CDS BCG_0835 NC_008769.1 910421 911107 D hypothetical protein 910421..911107 Mycobacterium bovis BCG str. Pasteur 1173P2 4696773 YP_976931.1 CDS BCG_0836 NC_008769.1 911123 911698 D In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (t-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808; hypothetical protein 911123..911698 Mycobacterium bovis BCG str. Pasteur 1173P2 4695970 YP_976932.1 CDS BCG_0837 NC_008769.1 911716 912822 D In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis,and Mycobacterium bovis BCG Pasteur a frameshift due to a single base deletion (t-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808; hypothetical protein 911716..912822 Mycobacterium bovis BCG str. Pasteur 1173P2 4697570 YP_976933.1 CDS BCG_0838c NC_008769.1 912857 913246 R hypothetical protein complement(912857..913246) Mycobacterium bovis BCG str. Pasteur 1173P2 4697112 YP_976934.1 CDS BCG_0839 NC_008769.1 913241 914200 D Differs from Rv0787 by 1aa H269Y; hypothetical protein 913241..914200 Mycobacterium bovis BCG str. Pasteur 1173P2 4696953 YP_976935.1 CDS BCG_0840 NC_008769.1 914306 914545 D With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway; phosphoribosylformylglycinamidine synthase subunit PurS 914306..914545 Mycobacterium bovis BCG str. Pasteur 1173P2 4696461 YP_976936.1 CDS purQ NC_008769.1 914542 915216 D catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I 914542..915216 Mycobacterium bovis BCG str. Pasteur 1173P2 4695934 YP_976937.1 CDS BCG_0842c NC_008769.1 915233 915832 R hypothetical protein complement(915233..915832) Mycobacterium bovis BCG str. Pasteur 1173P2 4696058 YP_976938.1 CDS BCG_0843c NC_008769.1 915854 916582 R hypothetical protein complement(915854..916582) Mycobacterium bovis BCG str. Pasteur 1173P2 4696959 YP_976939.1 CDS BCG_0844c NC_008769.1 916579 917622 R hypothetical protein complement(916579..917622) Mycobacterium bovis BCG str. Pasteur 1173P2 4696464 YP_976940.1 CDS BCG_0845c NC_008769.1 917619 918428 R GntR family transcriptional regulator complement(917619..918428) Mycobacterium bovis BCG str. Pasteur 1173P2 4696545 YP_976941.1 CDS BCG_0846 NC_008769.1 918501 918806 D hypothetical protein 918501..918806 Mycobacterium bovis BCG str. Pasteur 1173P2 4696129 YP_976942.1 CDS BCG_0847c NC_008769.1 918919 919530 R In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (a-*) splits Rv0794c into 2 parts; oxidoreductase complement(918919..919530) Mycobacterium bovis BCG str. Pasteur 1173P2 4695937 YP_976943.1 CDS BCG_0848c NC_008769.1 919518 920417 R In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (a-*) splits Rv0794c into 2 parts; oxidoreductase complement(919518..920417) Mycobacterium bovis BCG str. Pasteur 1173P2 4695990 YP_976944.1 CDS BCG_0849 NC_008769.1 920810 921904 D Differs from Rv0797 by 1aa L111M; transposase for insertion sequence element IS1547 920810..921904 Mycobacterium bovis BCG str. Pasteur 1173P2 4696459 YP_976945.1 CDS cfp29 NC_008769.1 921894 922691 R 29 kDa antigen cfp29 complement(921894..922691) Mycobacterium bovis BCG str. Pasteur 1173P2 4697352 YP_976946.1 CDS BCG_0851c NC_008769.1 922688 923695 R hypothetical protein complement(922688..923695) Mycobacterium bovis BCG str. Pasteur 1173P2 4695735 YP_976947.1 CDS pepC NC_008769.1 923740 925041 D catalyzes the removal of amino acids from the N termini of peptides; aminopeptidase 2 923740..925041 Mycobacterium bovis BCG str. Pasteur 1173P2 4696923 YP_976948.1 CDS BCG_0853 NC_008769.1 925053 925400 D hypothetical protein 925053..925400 Mycobacterium bovis BCG str. Pasteur 1173P2 4696120 YP_976949.1 CDS BCG_0854c NC_008769.1 925394 926050 R hypothetical protein complement(925394..926050) Mycobacterium bovis BCG str. Pasteur 1173P2 4696538 YP_976950.1 CDS purL NC_008769.1 926242 928506 D catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II 926242..928506 Mycobacterium bovis BCG str. Pasteur 1173P2 4696724 YP_976951.1 CDS BCG_0856 NC_008769.1 928503 929132 D hypothetical protein 928503..929132 Mycobacterium bovis BCG str. Pasteur 1173P2 4696435 YP_976952.1 CDS BCG_0857 NC_008769.1 929253 930209 D hypothetical protein 929253..930209 Mycobacterium bovis BCG str. Pasteur 1173P2 4697160 YP_976953.1 CDS cpsY NC_008769.1 930154 931752 R udp-glucose-4-epimerase cpsY complement(930154..931752) Mycobacterium bovis BCG str. Pasteur 1173P2 4696198 YP_976954.1 CDS BCG_0859 NC_008769.1 932057 932446 D hypothetical protein 932057..932446 Mycobacterium bovis BCG str. Pasteur 1173P2 4697925 YP_976955.1 CDS purF NC_008769.1 932533 934116 D Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 932533..934116 Mycobacterium bovis BCG str. Pasteur 1173P2 4695908 YP_976956.1 CDS purM NC_008769.1 934147 935241 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 934147..935241 Mycobacterium bovis BCG str. Pasteur 1173P2 4696432 YP_976957.1 CDS BCG_0862c NC_008769.1 935327 935509 R hypothetical protein complement(935327..935509) Mycobacterium bovis BCG str. Pasteur 1173P2 4696056 YP_976958.1 CDS BCG_0863c NC_008769.1 935656 936762 R hypothetical protein complement(935656..936762) Mycobacterium bovis BCG str. Pasteur 1173P2 4695579 YP_976959.1 CDS BCG_0864 NC_008769.1 936845 937714 D catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 936845..937714 Mycobacterium bovis BCG str. Pasteur 1173P2 4695488 YP_976960.1 CDS BCG_0865c NC_008769.1 937760 938440 R hypothetical protein complement(937760..938440) Mycobacterium bovis BCG str. Pasteur 1173P2 4695894 YP_976961.1 CDS sseC2 NC_008769.1 938603 938905 R hypothetical protein complement(938603..938905) Mycobacterium bovis BCG str. Pasteur 1173P2 4695759 YP_976962.1 CDS cysA2 NC_008769.1 938907 939740 R thiosulfate sulfurtransferase cysA2 complement(938907..939740) Mycobacterium bovis BCG str. Pasteur 1173P2 4696755 YP_976963.1 CDS thiX NC_008769.1 940033 940455 R thioredoxin thiX complement(940033..940455) Mycobacterium bovis BCG str. Pasteur 1173P2 4696054 YP_976964.1 CDS BCG_0869c NC_008769.1 940452 941264 R hypothetical protein complement(940452..941264) Mycobacterium bovis BCG str. Pasteur 1173P2 4697960 YP_976965.1 CDS BCG_0870 NC_008769.1 941394 942161 D Differs from Rv0818 by 1aa P97L; transcriptional regulatory protein 941394..942161 Mycobacterium bovis BCG str. Pasteur 1173P2 4697536 YP_976966.1 CDS BCG_0871 NC_008769.1 942158 943105 D hypothetical protein 942158..943105 Mycobacterium bovis BCG str. Pasteur 1173P2 4695764 YP_976967.1 CDS phoTa NC_008769.1 943148 943660 D In Mycobacterium tuberculosis strain H37Rv and Mycobacterium Bovis phoT exists as a single gene. In Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (g-*), splits phoT into to parts phoTa and phoTb. Differs from Rv0820 by 1aa L35F; phosphate-transport ATP-binding protein ABC transporter phoTa 943148..943660 Mycobacterium bovis BCG str. Pasteur 1173P2 4696609 YP_976968.1 CDS phoY2 NC_008769.1 943979 944620 R phosphate-transport system transcriptional regulatory protein phoY2 complement(943979..944620) Mycobacterium bovis BCG str. Pasteur 1173P2 4698180 YP_976969.1 CDS BCG_0875c NC_008769.1 944678 946732 R Differs from Rv0822c by 1aa P89H; hypothetical protein complement(944678..946732) Mycobacterium bovis BCG str. Pasteur 1173P2 4697036 YP_976970.1 CDS BCG_0876c NC_008769.1 946898 948067 R Differs from Rv0823c by 2aa C130G and L330F; transcriptional regulatory protein complement(946898..948067) Mycobacterium bovis BCG str. Pasteur 1173P2 4696233 YP_976971.1 CDS desA1 NC_008769.1 948155 949171 R acyl-ACP desaturase complement(948155..949171) Mycobacterium bovis BCG str. Pasteur 1173P2 4696995 YP_976972.1 CDS BCG_0878c NC_008769.1 949333 949974 R hypothetical protein complement(949333..949974) Mycobacterium bovis BCG str. Pasteur 1173P2 4697858 YP_976973.1 CDS BCG_0879 NC_008769.1 950055 951110 D Differs from Rv0826 by 1aa Q294R and Mb0849 by 1aa E97G; hypothetical protein 950055..951110 Mycobacterium bovis BCG str. Pasteur 1173P2 4695372 YP_976974.1 CDS BCG_0880c NC_008769.1 951162 951554 R transcriptional regulatory protein complement(951162..951554) Mycobacterium bovis BCG str. Pasteur 1173P2 4695707 YP_976975.1 CDS BCG_0881c NC_008769.1 951612 952034 R deaminase complement(951612..952034) Mycobacterium bovis BCG str. Pasteur 1173P2 4695591 YP_976976.1 CDS BCG_0882 NC_008769.1 951996 952286 D Differs from Rv0829 by 1aa G80A; transposase 951996..952286 Mycobacterium bovis BCG str. Pasteur 1173P2 4695662 YP_976977.1 CDS BCG_0883 NC_008769.1 952391 953296 D hypothetical protein 952391..953296 Mycobacterium bovis BCG str. Pasteur 1173P2 4696092 YP_976978.1 CDS BCG_0884c NC_008769.1 953315 954130 R hypothetical protein complement(953315..954130) Mycobacterium bovis BCG str. Pasteur 1173P2 4696527 YP_976979.1 CDS PE_PGRS13 NC_008769.1 955372 958104 D In Mycobacterium bovis BCG Pasteur PE-PGRS13 exists as a single gene. In Mycobacterium tuberculosis and Mycobacterium bovis, it is splitted in 2 genes PE-PGRS12 and PE-PGRS13; PE-PGRS family protein 955372..958104 Mycobacterium bovis BCG str. Pasteur 1173P2 4695947 YP_976980.1 CDS PE_PGRS14 NC_008769.1 958331 960979 R In Mycobacterium bovis, deletions of 143 bp and 9 bp (cgccgttgc-*), leads to a shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur (831 aa versus 882 aa); PE-PGRS family protein complement(958331..960979) Mycobacterium bovis BCG str. Pasteur 1173P2 4697795 YP_976981.1 CDS lpqQ NC_008769.1 961447 962091 D Differs from Rv0835 by 1aa G162D; lipoprotein lpqQ 961447..962091 Mycobacterium bovis BCG str. Pasteur 1173P2 4697796 YP_976982.1 CDS BCG_0888c NC_008769.1 962704 963426 R In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a single base transition (a-g) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (240 aa versus 217 aa); hypothetical protein complement(962704..963426) Mycobacterium bovis BCG str. Pasteur 1173P2 4696678 YP_976983.1 CDS BCG_0889c NC_008769.1 963497 964525 R hypothetical protein complement(963497..964525) Mycobacterium bovis BCG str. Pasteur 1173P2 4696154 YP_976984.1 CDS lpqR NC_008769.1 965214 965996 D In Mycobacterium bovis, a 6bp insertion (*-cggccc) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (258 aa versus 256 aa). In Mycobacterium bovis BCG Pasteur, a 12bp insertion (compared to its homolog in Mycobacterium tuberculosis strain H37Rv) and a 6bp insertion (compared to its homolog in Mycobacterium bovis) leads to an even longer product (260 aa); lipoprotein lpqR 965214..965996 Mycobacterium bovis BCG str. Pasteur 1173P2 4695502 YP_976985.1 CDS BCG_0891 NC_008769.1 966083 966895 D hypothetical protein 966083..966895 Mycobacterium bovis BCG str. Pasteur 1173P2 4696679 YP_976986.1 CDS pip NC_008769.1 966963 967823 R proline iminopeptidase pip complement(966963..967823) Mycobacterium bovis BCG str. Pasteur 1173P2 4695429 YP_976987.1 CDS BCG_0893 NC_008769.1 968099 968341 D Differs from Rv0841 by 1aa F29V; hypothetical protein 968099..968341 Mycobacterium bovis BCG str. Pasteur 1173P2 4699304 YP_976988.1 CDS BCG_0894 NC_008769.1 968618 969910 D integral membrane protein 968618..969910 Mycobacterium bovis BCG str. Pasteur 1173P2 4696946 YP_976989.1 CDS BCG_0895 NC_008769.1 969894 970898 D Differs from Rv0843 by 1aa G191D and from Mb0866 by 1aa A309D; dehydrogenase 969894..970898 Mycobacterium bovis BCG str. Pasteur 1173P2 4695952 YP_976990.1 CDS narL NC_008769.1 970962 971612 R Differs from Mb0867c by 1aa A73P; nitrate/nitrite response transcriptional regulatory protein narL complement(970962..971612) Mycobacterium bovis BCG str. Pasteur 1173P2 4695686 YP_976991.1 CDS BCG_0897 NC_008769.1 971696 972973 D Differs from Rv0845 by 1aa E219A; two component sensor kinase 971696..972973 Mycobacterium bovis BCG str. Pasteur 1173P2 4697468 YP_976992.1 CDS BCG_0898c NC_008769.1 973186 974700 R Differs from Mb0869c by 1aa Y411H; oxidase complement(973186..974700) Mycobacterium bovis BCG str. Pasteur 1173P2 4697717 YP_976993.1 CDS lpqS NC_008769.1 974849 975241 D Differs from Rv0847 by 1aa V128A; lipoprotein lpqS 974849..975241 Mycobacterium bovis BCG str. Pasteur 1173P2 4697647 YP_976994.1 CDS cysK2 NC_008769.1 975444 976562 D Differs from Rv0848 by 1aa S93G, and from Mb0871 by 1aa V137G; cysteine synthase a cysK2 975444..976562 Mycobacterium bovis BCG str. Pasteur 1173P2 4696680 YP_976995.1 CDS BCG_0901 NC_008769.1 976562 977821 D integral membrane transport protein 976562..977821 Mycobacterium bovis BCG str. Pasteur 1173P2 4695388 YP_976996.1 CDS BCG_0902 NC_008769.1 977818 978150 D transposase 977818..978150 Mycobacterium bovis BCG str. Pasteur 1173P2 4697340 YP_976997.1 CDS BCG_0903c NC_008769.1 978147 978974 R Differs from Rv0851c by 1aa G59S and from Mb0874c by 1aa V84F; short chain dehydrogenase complement(978147..978974) Mycobacterium bovis BCG str. Pasteur 1173P2 4696791 YP_976998.1 CDS fadD16 NC_008769.1 979065 979901 D fatty-acid-CoA ligase fadD16 979065..979901 Mycobacterium bovis BCG str. Pasteur 1173P2 4696017 YP_976999.1 CDS pdc NC_008769.1 979942 981624 R pyruvate or indole-3-pyruvate decarboxylase pdc complement(979942..981624) Mycobacterium bovis BCG str. Pasteur 1173P2 4696314 YP_977000.1 CDS BCG_0906 NC_008769.1 981689 982132 D hypothetical protein 981689..982132 Mycobacterium bovis BCG str. Pasteur 1173P2 4698421 YP_977001.1 CDS far NC_008769.1 982138 983217 D fatty-acid-CoA racemase far 982138..983217 Mycobacterium bovis BCG str. Pasteur 1173P2 4697001 YP_977002.1 CDS BCG_0908 NC_008769.1 983330 983734 D hypothetical protein 983330..983734 Mycobacterium bovis BCG str. Pasteur 1173P2 4695682 YP_977003.1 CDS BCG_0909 NC_008769.1 983762 984235 D hypothetical protein 983762..984235 Mycobacterium bovis BCG str. Pasteur 1173P2 4696557 YP_977004.1 CDS BCG_0910c NC_008769.1 984232 985425 R aminotransferase complement(984232..985425) Mycobacterium bovis BCG str. Pasteur 1173P2 4696031 YP_977005.1 CDS fadA NC_008769.1 985582 986793 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 985582..986793 Mycobacterium bovis BCG str. Pasteur 1173P2 4696997 YP_977006.1 CDS fadB NC_008769.1 986798 988960 D Differs from Rv0860 by 1aa T701A; fatty oxidation protein fadB 986798..988960 Mycobacterium bovis BCG str. Pasteur 1173P2 4695395 YP_977007.1 CDS BCG_0913c NC_008769.1 989028 990656 R Differs from Rv0861c by 1aa A258V; DNA helicase complement(989028..990656) Mycobacterium bovis BCG str. Pasteur 1173P2 4697224 YP_977008.1 CDS BCG_0914c NC_008769.1 990794 993064 R Differs from Rv0862c by 2aa F224L and S749L, and from Mb0885c by 1aa F224L; hypothetical protein complement(990794..993064) Mycobacterium bovis BCG str. Pasteur 1173P2 4697572 YP_977009.1 CDS BCG_0915 NC_008769.1 993051 993332 D hypothetical protein 993051..993332 Mycobacterium bovis BCG str. Pasteur 1173P2 4695688 YP_977010.1 CDS moaC NC_008769.1 993416 993844 D MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 993416..993844 Mycobacterium bovis BCG str. Pasteur 1173P2 4696001 YP_977011.1 CDS mog NC_008769.1 993841 994323 D molybdopterin biosynthesis mog protein 993841..994323 Mycobacterium bovis BCG str. Pasteur 1173P2 4695606 YP_977012.1 CDS moaE2 NC_008769.1 994320 994745 D molybdenum cofactor biosynthesis protein e2 moaE2 994320..994745 Mycobacterium bovis BCG str. Pasteur 1173P2 4698907 YP_977013.1 CDS rpfA NC_008769.1 994763 995986 R In Mycobacterium bovis, a 240 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur (327 aa versus 407 aa). Differs from Rv0867c by 1aa E235D; resuscitation-promoting factor rpfA complement(994763..995986) Mycobacterium bovis BCG str. Pasteur 1173P2 4698496 YP_977014.1 CDS moaD2 NC_008769.1 996434 996712 R molybdenum cofactor biosynthesis protein D 2 moaD2 complement(996434..996712) Mycobacterium bovis BCG str. Pasteur 1173P2 4697712 YP_977015.1 CDS moaA NC_008769.1 996716 997798 R together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A complement(996716..997798) Mycobacterium bovis BCG str. Pasteur 1173P2 4698495 YP_977016.1 CDS BCG_0922c NC_008769.1 997795 998184 R Differs from Mb0894c by 1aa G29S; hypothetical protein complement(997795..998184) Mycobacterium bovis BCG str. Pasteur 1173P2 4698507 YP_977017.1 CDS cspB NC_008769.1 998349 998756 D cold shock-like protein B cspB 998349..998756 Mycobacterium bovis BCG str. Pasteur 1173P2 4696925 YP_977018.1 CDS PE_PGRS15 NC_008769.1 998875 1000704 R In Mycobacterium bovis BCG Pasteur, a 9 bp in-frame insertion (compared to Mycobacterium tuberculosis strain H37Rv), leads to a lightly longer product (609 aa versus 606 aa). In Mycobacterium bovis, an additional 3 bp in-frame deletion (compared to Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur) leads to a product of 608 aa; PE-PGRS family protein complement(998875..1000704) Mycobacterium bovis BCG str. Pasteur 1173P2 4697910 YP_977019.1 CDS fadE10 NC_008769.1 1000965 1002917 D acyl-CoA dehydrogenase fadE10 1000965..1002917 Mycobacterium bovis BCG str. Pasteur 1173P2 4697797 YP_977020.1 CDS BCG_0926c NC_008769.1 1003006 1004166 R hypothetical protein complement(1003006..1004166) Mycobacterium bovis BCG str. Pasteur 1173P2 4695873 YP_977021.1 CDS BCG_0927c NC_008769.1 1004266 1004754 R hypothetical protein complement(1004266..1004754) Mycobacterium bovis BCG str. Pasteur 1173P2 4697494 YP_977022.1 CDS BCG_0928c NC_008769.1 1004751 1006397 R Differs from Mb0900c by 1aa D26G; hypothetical protein complement(1004751..1006397) Mycobacterium bovis BCG str. Pasteur 1173P2 4696439 YP_977023.1 CDS BCG_0929 NC_008769.1 1006535 1007323 D hypothetical protein 1006535..1007323 Mycobacterium bovis BCG str. Pasteur 1173P2 4696916 YP_977024.1 CDS PPE13 NC_008769.1 1007332 1008660 R In Mycobacterium bovis and Mycobaterium bovis BCG Pasteur, a single base deletion (a-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (438 aa versus 443 aa). Differs from Rv0878c and Mb0902c by 1aa K436Q; PPE family protein complement(1007332..1008660) Mycobacterium bovis BCG str. Pasteur 1173P2 4697552 YP_977025.1 CDS BCG_0931c NC_008769.1 1008938 1009213 R hypothetical protein complement(1008938..1009213) Mycobacterium bovis BCG str. Pasteur 1173P2 4697236 YP_977026.1 CDS BCG_0932 NC_008769.1 1009391 1009822 D MarR family transcriptional regulator 1009391..1009822 Mycobacterium bovis BCG str. Pasteur 1173P2 4696924 YP_977027.1 CDS BCG_0933 NC_008769.1 1009819 1010685 D rRNA methyltransferase 1009819..1010685 Mycobacterium bovis BCG str. Pasteur 1173P2 4695977 YP_977028.1 CDS BCG_0934 NC_008769.1 1010682 1010966 D hypothetical protein 1010682..1010966 Mycobacterium bovis BCG str. Pasteur 1173P2 4696241 YP_977029.1 CDS BCG_0935c NC_008769.1 1010963 1011724 R hypothetical protein complement(1010963..1011724) Mycobacterium bovis BCG str. Pasteur 1173P2 4696341 YP_977030.1 CDS serC NC_008769.1 1011881 1013011 R catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase complement(1011881..1013011) Mycobacterium bovis BCG str. Pasteur 1173P2 4696541 YP_977031.1 CDS BCG_0937 NC_008769.1 1013219 1014241 D hypothetical protein 1013219..1014241 Mycobacterium bovis BCG str. Pasteur 1173P2 4696251 YP_977032.1 CDS fprB NC_008769.1 1014260 1015987 D NADPH:adrenodoxin oxidoreductase fprB 1014260..1015987 Mycobacterium bovis BCG str. Pasteur 1173P2 4696398 YP_977033.1 CDS BCG_0939c NC_008769.1 1015970 1016428 R hypothetical protein complement(1015970..1016428) Mycobacterium bovis BCG str. Pasteur 1173P2 4697656 YP_977034.1 CDS BCG_0940 NC_008769.1 1017690 1019162 D hypothetical protein 1017690..1019162 Mycobacterium bovis BCG str. Pasteur 1173P2 4696587 YP_977035.1 CDS citA NC_008769.1 1019197 1020318 R forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; citrate synthase 2 complement(1019197..1020318) Mycobacterium bovis BCG str. Pasteur 1173P2 4696575 YP_977036.1 CDS BCG_0942c NC_008769.1 1020405 1023053 R Differs from Rv0890c by 1aa A866P; LuxR family transcriptional regulator complement(1020405..1023053) Mycobacterium bovis BCG str. Pasteur 1173P2 4697911 YP_977037.1 CDS BCG_0943c NC_008769.1 1023055 1023912 R Differs from Rv0891c by 1aa G37V; transcriptional regulatory protein complement(1023055..1023912) Mycobacterium bovis BCG str. Pasteur 1173P2 4696599 YP_977038.1 CDS BCG_0944 NC_008769.1 1024310 1025797 D monooxygenase 1024310..1025797 Mycobacterium bovis BCG str. Pasteur 1173P2 4696652 YP_977039.1 CDS BCG_0945c NC_008769.1 1025775 1026752 R hypothetical protein complement(1025775..1026752) Mycobacterium bovis BCG str. Pasteur 1173P2 4696630 YP_977040.1 CDS BCG_0946 NC_008769.1 1026981 1028162 D LuxR family transcriptional regulator 1026981..1028162 Mycobacterium bovis BCG str. Pasteur 1173P2 4696683 YP_977041.1 CDS BCG_0947 NC_008769.1 1028239 1029756 D hypothetical protein 1028239..1029756 Mycobacterium bovis BCG str. Pasteur 1173P2 4696714 YP_977042.1 CDS gltA NC_008769.1 1029946 1031241 D type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 1029946..1031241 Mycobacterium bovis BCG str. Pasteur 1173P2 4696774 YP_977043.1 CDS BCG_0949c NC_008769.1 1031282 1032889 R oxidoreductase complement(1031282..1032889) Mycobacterium bovis BCG str. Pasteur 1173P2 4696570 YP_977044.1 CDS BCG_0950c NC_008769.1 1032915 1033178 R hypothetical protein complement(1032915..1033178) Mycobacterium bovis BCG str. Pasteur 1173P2 4696859 YP_977045.1 CDS ompA NC_008769.1 1033286 1034266 D outer membrane protein A ompA 1033286..1034266 Mycobacterium bovis BCG str. Pasteur 1173P2 4696918 YP_977046.1 CDS BCG_0952 NC_008769.1 1034279 1034431 D hypothetical protein 1034279..1034431 Mycobacterium bovis BCG str. Pasteur 1173P2 4696326 YP_977047.1 CDS BCG_0953 NC_008769.1 1034431 1034958 D hypothetical protein 1034431..1034958 Mycobacterium bovis BCG str. Pasteur 1173P2 4697058 YP_977048.1 CDS prrB NC_008769.1 1034975 1036315 R two component sensor histidine kinase prrB complement(1034975..1036315) Mycobacterium bovis BCG str. Pasteur 1173P2 4697086 YP_977049.1 CDS prrA NC_008769.1 1036326 1037036 R two component response transcriptional regulatory protein prrA complement(1036326..1037036) Mycobacterium bovis BCG str. Pasteur 1173P2 4697277 YP_977050.1 CDS accD3 NC_008769.1 1037167 1038654 R acetyl-coenzyme A carboxylase carboxyl transferase (subunit beta) accD3 complement(1037167..1038654) Mycobacterium bovis BCG str. Pasteur 1173P2 4697276 YP_977051.1 CDS echA6 NC_008769.1 1038681 1039412 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1038681..1039412 Mycobacterium bovis BCG str. Pasteur 1173P2 4698644 YP_977052.1 CDS BCG_0958 NC_008769.1 1039418 1040536 D hypothetical protein 1039418..1040536 Mycobacterium bovis BCG str. Pasteur 1173P2 4697107 YP_977053.1 CDS BCG_0959 NC_008769.1 1040629 1042209 D In Mycobacterium bovis BCG Pasteur and in Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Rv0907 by 1aa, L322P; hypothetical protein 1040629..1042209 Mycobacterium bovis BCG str. Pasteur 1173P2 4697187 YP_977054.1 CDS ctpE NC_008769.1 1042206 1044599 D metal cation transporter atpase P-type ctpE 1042206..1044599 Mycobacterium bovis BCG str. Pasteur 1173P2 4697208 YP_977055.1 CDS BCG_0961 NC_008769.1 1045156 1045335 D Differs from Rv0909 by 1aa, Q45H; hypothetical protein 1045156..1045335 Mycobacterium bovis BCG str. Pasteur 1173P2 4696356 YP_977056.1 CDS BCG_0962 NC_008769.1 1045341 1045775 D hypothetical protein 1045341..1045775 Mycobacterium bovis BCG str. Pasteur 1173P2 4697226 YP_977057.1 CDS BCG_0963 NC_008769.1 1045873 1046646 D hypothetical protein 1045873..1046646 Mycobacterium bovis BCG str. Pasteur 1173P2 4697213 YP_977058.1 CDS BCG_0964 NC_008769.1 1046711 1047160 D hypothetical protein 1046711..1047160 Mycobacterium bovis BCG str. Pasteur 1173P2 4697354 YP_977059.1 CDS BCG_0965c NC_008769.1 1047692 1049200 R Differs from Rv0913c by 1aa P233L; dioxygenase complement(1047692..1049200) Mycobacterium bovis BCG str. Pasteur 1173P2 4697274 YP_977060.1 CDS BCG_0966c NC_008769.1 1049202 1050440 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(1049202..1050440) Mycobacterium bovis BCG str. Pasteur 1173P2 4697479 YP_977061.1 CDS PPE14 NC_008769.1 1050533 1051804 R PPE family protein complement(1050533..1051804) Mycobacterium bovis BCG str. Pasteur 1173P2 4697589 YP_977062.1 CDS PE7 NC_008769.1 1051819 1052118 R PE family protein complement(1051819..1052118) Mycobacterium bovis BCG str. Pasteur 1173P2 4697237 YP_977063.1 CDS betP NC_008769.1 1052562 1054343 D glycine betaine transport integral membrane protein betP 1052562..1054343 Mycobacterium bovis BCG str. Pasteur 1173P2 4696204 YP_977064.1 CDS BCG_0970 NC_008769.1 1054686 1055162 D Differs from Rv0918 by 1aa, G46S; hypothetical protein 1054686..1055162 Mycobacterium bovis BCG str. Pasteur 1173P2 4695658 YP_977065.1 CDS BCG_0971 NC_008769.1 1055159 1055659 D hypothetical protein 1055159..1055659 Mycobacterium bovis BCG str. Pasteur 1173P2 4697674 YP_977066.1 CDS BCG_0972c NC_008769.1 1055972 1057291 R Differs from Rv0920c by 1aa, E249D; transposase complement(1055972..1057291) Mycobacterium bovis BCG str. Pasteur 1173P2 4697082 YP_977067.1 CDS BCG_0973 NC_008769.1 1057579 1058160 D resolvase 1057579..1058160 Mycobacterium bovis BCG str. Pasteur 1173P2 4697653 YP_977068.1 CDS BCG_0974 NC_008769.1 1058160 1059812 D transposase 1058160..1059812 Mycobacterium bovis BCG str. Pasteur 1173P2 4697695 YP_977069.1 CDS BCG_0975c NC_008769.1 1059988 1061052 R hypothetical protein complement(1059988..1061052) Mycobacterium bovis BCG str. Pasteur 1173P2 4697955 YP_977070.1 CDS mntH NC_008769.1 1061053 1062339 R In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur, Rv0924c and Rv0925c exist as 2 genes. In Mycobacterium bovis, a single base deletion (t-*) leads to a single product, Mb0948c. Differs from Rv0924c by 1aa, A216P; manganese transport protein MntH complement(1061053..1062339) Mycobacterium bovis BCG str. Pasteur 1173P2 4698253 YP_977071.1 CDS BCG_0977c NC_008769.1 1062371 1063108 R In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur, Rv0924c and Rv0925c exist as 2 genes. In Mycobacterium bovis, a single base deletion (t-*) leads to a single product,Mb0948c; divalent cation-transport integral membrane protein mntH complement(1062371..1063108) Mycobacterium bovis BCG str. Pasteur 1173P2 4698505 YP_977072.1 CDS BCG_0978c NC_008769.1 1063185 1064261 R hypothetical protein complement(1063185..1064261) Mycobacterium bovis BCG str. Pasteur 1173P2 4698006 YP_977073.1 CDS BCG_0979c NC_008769.1 1064315 1065106 R short chain dehydrogenase complement(1064315..1065106) Mycobacterium bovis BCG str. Pasteur 1173P2 4697633 YP_977074.1 CDS pstS3 NC_008769.1 1065378 1066490 D periplasmic phosphate-binding lipoprotein pstS3 1065378..1066490 Mycobacterium bovis BCG str. Pasteur 1173P2 4697553 YP_977075.1 CDS pstC2 NC_008769.1 1066503 1067477 D phosphate-transport integral membrane ABC transporter pstC2 1066503..1067477 Mycobacterium bovis BCG str. Pasteur 1173P2 4697314 YP_977076.1 CDS pstA1 NC_008769.1 1067474 1068388 D Differs from Rv0930 by 1aa, T5M; phosphate-transport integral membrane ABC transporter pstA1 1067474..1068388 Mycobacterium bovis BCG str. Pasteur 1173P2 4695695 YP_977077.1 CDS pknDb NC_008769.1 1068395 1069504 R In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-t) splits pknD into 2 parts, pknDa and pknDb; Ser/Thr protein kinase complement(1068395..1069504) Mycobacterium bovis BCG str. Pasteur 1173P2 4696825 YP_977078.1 CDS pknDa NC_008769.1 1069515 1070390 R In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-t) splits pknD into 2 parts, pknDa and pknDb; Ser/Thr protein kinase complement(1069515..1070390) Mycobacterium bovis BCG str. Pasteur 1173P2 4696551 YP_977079.1 CDS pstS2 NC_008769.1 1070412 1071524 R Differs from Rv0932c by 1aa, A115S; periplasmic phosphate-binding lipoprotein pstS2 complement(1070412..1071524) Mycobacterium bovis BCG str. Pasteur 1173P2 4696550 YP_977080.1 CDS pstBa NC_008769.1 1071740 1071955 D In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base insertion (*-t, position 1041448-1041449) splits pstB into 2 parts, pstBa and pstBb; hypothetical protein 1071740..1071955 Mycobacterium bovis BCG str. Pasteur 1173P2 4695698 YP_977081.1 CDS pstBb NC_008769.1 1071930 1072571 D In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base insertion (*-t, position 1041448-1041449) splits pstB into 2 parts, pstBa and pstBb; phosphate-transport protein ABC transporter pstBb 1071930..1072571 Mycobacterium bovis BCG str. Pasteur 1173P2 4696827 YP_977082.1 CDS pstS1 NC_008769.1 1072592 1073716 D Differs from Rv0934 by 1aa, A352V; periplasmic phosphate-binding lipoprotein pstS1 1072592..1073716 Mycobacterium bovis BCG str. Pasteur 1173P2 4696828 YP_977083.1 CDS pstC1 NC_008769.1 1073776 1074792 D phosphate ABC transporter transmembrane protein 1073776..1074792 Mycobacterium bovis BCG str. Pasteur 1173P2 4695697 YP_977084.1 CDS pstA2 NC_008769.1 1074794 1075699 D phosphate ABC transporter transmembrane protein 1074794..1075699 Mycobacterium bovis BCG str. Pasteur 1173P2 4695694 YP_977085.1 CDS BCG_0991c NC_008769.1 1075676 1076497 R hypothetical protein complement(1075676..1076497) Mycobacterium bovis BCG str. Pasteur 1173P2 4696826 YP_977086.1 CDS BCG_0992 NC_008769.1 1076613 1078892 D catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA and has been shown to have polymerase activity; ATP-dependent DNA ligase 1076613..1078892 Mycobacterium bovis BCG str. Pasteur 1173P2 4697382 YP_977087.1 CDS BCG_0993 NC_008769.1 1078889 1080823 D bifunctional enzyme: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase + cyclase/dehydrase 1078889..1080823 Mycobacterium bovis BCG str. Pasteur 1173P2 4697384 YP_977088.1 CDS BCG_0994c NC_008769.1 1081070 1081936 R oxidoreductase complement(1081070..1081936) Mycobacterium bovis BCG str. Pasteur 1173P2 4697379 YP_977089.1 CDS BCG_0995c NC_008769.1 1082021 1082794 R hypothetical protein complement(1082021..1082794) Mycobacterium bovis BCG str. Pasteur 1173P2 4697472 YP_977090.1 CDS BCG_0996 NC_008769.1 1082837 1083115 D hypothetical protein 1082837..1083115 Mycobacterium bovis BCG str. Pasteur 1173P2 4697366 YP_977091.1 CDS BCG_0997c NC_008769.1 1083173 1084213 R monooxygenase complement(1083173..1084213) Mycobacterium bovis BCG str. Pasteur 1173P2 4697375 YP_977092.1 CDS BCG_0998 NC_008769.1 1084242 1084718 D formamidopyrimidine-DNA glycosylase 1084242..1084718 Mycobacterium bovis BCG str. Pasteur 1173P2 4697368 YP_977093.1 CDS BCG_0999 NC_008769.1 1084724 1085485 D Differs from Rv0945 by 1aa, G180R; short chain dehydrogenase 1084724..1085485 Mycobacterium bovis BCG str. Pasteur 1173P2 4697370 YP_977094.1 CDS pgi NC_008769.1 1085501 1087162 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(1085501..1087162) Mycobacterium bovis BCG str. Pasteur 1173P2 4697144 YP_977095.1 CDS BCG_1001c NC_008769.1 1087777 1088007 R mycolyl transferase complement(1087777..1088007) Mycobacterium bovis BCG str. Pasteur 1173P2 4698545 YP_977096.1 CDS BCG_1002c NC_008769.1 1088123 1088440 R hypothetical protein complement(1088123..1088440) Mycobacterium bovis BCG str. Pasteur 1173P2 4697189 YP_977097.1 CDS uvrD1 NC_008769.1 1088737 1091052 D ATP dependent DNA helicase uvrD1 1088737..1091052 Mycobacterium bovis BCG str. Pasteur 1173P2 4696957 YP_977098.1 CDS BCG_1004c NC_008769.1 1091133 1092131 R hypothetical protein complement(1091133..1092131) Mycobacterium bovis BCG str. Pasteur 1173P2 4697229 YP_977099.1 CDS sucC NC_008769.1 1092441 1093604 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1092441..1093604 Mycobacterium bovis BCG str. Pasteur 1173P2 4695639 YP_977100.1 CDS sucD NC_008769.1 1093617 1094528 D Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 1093617..1094528 Mycobacterium bovis BCG str. Pasteur 1173P2 4696766 YP_977101.1 CDS BCG_1007c NC_008769.1 1094591 1095439 R Differs from Rv0953c and Mb0978c by 1aa, A50T; oxidoreductase complement(1094591..1095439) Mycobacterium bovis BCG str. Pasteur 1173P2 4696767 YP_977102.1 CDS BCG_1008 NC_008769.1 1095604 1096515 D hypothetical protein 1095604..1096515 Mycobacterium bovis BCG str. Pasteur 1173P2 4696030 YP_977103.1 CDS BCG_1009 NC_008769.1 1096555 1097922 D integral membrane protein 1096555..1097922 Mycobacterium bovis BCG str. Pasteur 1173P2 4696002 YP_977104.1 CDS purN NC_008769.1 1098038 1098685 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 1098038..1098685 Mycobacterium bovis BCG str. Pasteur 1173P2 4695999 YP_977105.1 CDS purH NC_008769.1 1098682 1100253 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1098682..1100253 Mycobacterium bovis BCG str. Pasteur 1173P2 4696057 YP_977106.1 CDS BCG_1012 NC_008769.1 1100360 1101739 D Differs from Rv0958 by 1aa, P274S; magnesium chelatase 1100360..1101739 Mycobacterium bovis BCG str. Pasteur 1173P2 4696433 YP_977107.1 CDS BCG_1013 NC_008769.1 1101732 1103750 D hypothetical protein 1101732..1103750 Mycobacterium bovis BCG str. Pasteur 1173P2 4695555 YP_977108.1 CDS BCG_1013A NC_008769.1 1103804 1104025 D antitoxin 1103804..1104025 Mycobacterium bovis BCG str. Pasteur 1173P2 4696930 YP_977109.1 CDS BCG_1014 NC_008769.1 1104022 1104405 D hypothetical protein 1104022..1104405 Mycobacterium bovis BCG str. Pasteur 1173P2 4696039 YP_977110.1 CDS BCG_1015 NC_008769.1 1104551 1104898 D integral membrane protein 1104551..1104898 Mycobacterium bovis BCG str. Pasteur 1173P2 4695997 YP_977111.1 CDS lprP NC_008769.1 1104917 1105591 R Differs from Rv0962c by 1aa, L186P; lipoprotein lprP complement(1104917..1105591) Mycobacterium bovis BCG str. Pasteur 1173P2 4696254 YP_977112.1 CDS BCG_1017c NC_008769.1 1105774 1106574 R Differs from Rv0963c and Mb0988c by 1aa, S258G; hypothetical protein complement(1105774..1106574) Mycobacterium bovis BCG str. Pasteur 1173P2 4698592 YP_977113.1 CDS BCG_1018c NC_008769.1 1106673 1107155 R Differs from Rv0964c by 1aa, T124P; hypothetical protein complement(1106673..1107155) Mycobacterium bovis BCG str. Pasteur 1173P2 4696215 YP_977114.1 CDS BCG_1019c NC_008769.1 1107255 1107674 R Differs from Rv0965c by 1aa, H94R; hypothetical protein complement(1107255..1107674) Mycobacterium bovis BCG str. Pasteur 1173P2 4696219 YP_977115.1 CDS BCG_1020c NC_008769.1 1107710 1108312 R Differs from Rv0966c by 2aa, A175V, G186W; hypothetical protein complement(1107710..1108312) Mycobacterium bovis BCG str. Pasteur 1173P2 4695646 YP_977116.1 CDS BCG_1021 NC_008769.1 1108451 1108810 D hypothetical protein 1108451..1108810 Mycobacterium bovis BCG str. Pasteur 1173P2 4697033 YP_977117.1 CDS BCG_1022 NC_008769.1 1108867 1109163 D hypothetical protein 1108867..1109163 Mycobacterium bovis BCG str. Pasteur 1173P2 4697050 YP_977118.1 CDS ctpV NC_008769.1 1109219 1111531 D Differs from Rv0969 by 1aa, N484D; metal cation transporter P-type atpase ctpV 1109219..1111531 Mycobacterium bovis BCG str. Pasteur 1173P2 4696984 YP_977119.1 CDS BCG_1024 NC_008769.1 1111528 1112160 D integral membrane protein 1111528..1112160 Mycobacterium bovis BCG str. Pasteur 1173P2 4697951 YP_977120.1 CDS echA7 NC_008769.1 1112251 1113060 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(1112251..1113060) Mycobacterium bovis BCG str. Pasteur 1173P2 4696218 YP_977121.1 CDS fadE12 NC_008769.1 1113060 1114226 R Differs from Rv0972c by 1aa, H236Q; acyl-CoA dehydrogenase fadE12 complement(1113060..1114226) Mycobacterium bovis BCG str. Pasteur 1173P2 4696186 YP_977122.1 CDS accA2 NC_008769.1 1114223 1116226 R Differs from Rv0973c by 1aa, F220I; acetyl-/propionyl-coenzyme A carboxylase alpha chain subunit alpha accA2 complement(1114223..1116226) Mycobacterium bovis BCG str. Pasteur 1173P2 4695874 YP_977123.1 CDS accD2 NC_008769.1 1116232 1117821 R Differs from Rv0974c by 1aa, K51N; acetyl-/propionyl-coa carboxylase subunit beta accD2 complement(1116232..1117821) Mycobacterium bovis BCG str. Pasteur 1173P2 4698782 YP_977124.1 CDS fadE13 NC_008769.1 1117824 1118972 R In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG pasteur; acyl-coa dehydrogenase fadE13 complement(1117824..1118972) Mycobacterium bovis BCG str. Pasteur 1173P2 4698803 YP_977125.1 CDS BCG_1030c NC_008769.1 1118969 1120651 R hypothetical protein complement(1118969..1120651) Mycobacterium bovis BCG str. Pasteur 1173P2 4695875 YP_977126.1 CDS PE_PGRS16 NC_008769.1 1120850 1123621 D PE-PGRS family protein 1120850..1123621 Mycobacterium bovis BCG str. Pasteur 1173P2 4696955 YP_977127.1 CDS PE_PGRS17 NC_008769.1 1123838 1124845 R In Mycobacterium bovis and in Mycobacterim bovis BCG Pasteur, a 115 bp to 127 bp substitution leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (335 aa versus 331 aa); PE-PGRS family protein complement(1123838..1124845) Mycobacterium bovis BCG str. Pasteur 1173P2 4697798 YP_977128.1 CDS BCG_1033c NC_008769.1 1125159 1125353 R hypothetical protein complement(1125159..1125353) Mycobacterium bovis BCG str. Pasteur 1173P2 4697719 YP_977129.1 CDS rpmF NC_008769.1 1125375 1125548 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1125375..1125548 Mycobacterium bovis BCG str. Pasteur 1173P2 4696844 YP_977130.1 CDS PE_PGRS18 NC_008769.1 1125567 1126940 R Differs from Rv0980c by 1aa, Q43H, and from Mb1006c by 1aa, A270T; PE-PGRS family protein complement(1125567..1126940) Mycobacterium bovis BCG str. Pasteur 1173P2 4696786 YP_977131.1 CDS mprA NC_008769.1 1127305 1127997 D Differs from Rv0981 by 1aa, S70G; two component response transcriptional regulatory protein MprA 1127305..1127997 Mycobacterium bovis BCG str. Pasteur 1173P2 4697720 YP_977132.1 CDS mprB NC_008769.1 1127997 1129511 D Differs from Rv0982 by 1aa, H339L; two component sensor kinase mprB 1127997..1129511 Mycobacterium bovis BCG str. Pasteur 1173P2 4696126 YP_977133.1 CDS BCG_1038 NC_008769.1 1129555 1130949 D Differs from Rv0983 by 1aa, P390L; serine protease 1129555..1130949 Mycobacterium bovis BCG str. Pasteur 1173P2 4696127 YP_977134.1 CDS moaB2 NC_008769.1 1130949 1131494 D pterin-4-alpha-carbinolamine dehydratase moaB2 1130949..1131494 Mycobacterium bovis BCG str. Pasteur 1173P2 4695982 YP_977135.1 CDS mscL NC_008769.1 1131514 1131969 R forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel complement(1131514..1131969) Mycobacterium bovis BCG str. Pasteur 1173P2 4695603 YP_977136.1 CDS BCG_1041 NC_008769.1 1132292 1133038 D Differs from Rv0986 by 1aa, L228V; adhesion component transport atp-binding protein ABC transporter 1132292..1133038 Mycobacterium bovis BCG str. Pasteur 1173P2 4697734 YP_977137.1 CDS BCG_1042 NC_008769.1 1133031 1135598 D In Mycobacterium bovis BCG Pasteur and Mycobacterium tuberculosis strain H37Rv, Rv0987 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a stop codon that splits Rv0987 in two parts, Mb1013 and Mb1014. Differs from Rv0987 by 1aa, V717F; adhesion component transport transmembrane protein 1133031..1135598 Mycobacterium bovis BCG str. Pasteur 1173P2 4695392 YP_977138.1 CDS BCG_1043 NC_008769.1 1135605 1136765 D Differs from Rv0988 by 2aa, I57V, D135Y; hypothetical protein 1135605..1136765 Mycobacterium bovis BCG str. Pasteur 1173P2 4695975 YP_977139.1 CDS grcC2 NC_008769.1 1136894 1137871 R Differs from Rv0989c by 1aa, V321I; polyprenyl-diphosphate synthase grcC2 complement(1136894..1137871) Mycobacterium bovis BCG str. Pasteur 1173P2 4696693 YP_977140.1 CDS BCG_1045c NC_008769.1 1137932 1138588 R Differs from Rv0990c by 1aa, A54S; hypothetical protein complement(1137932..1138588) Mycobacterium bovis BCG str. Pasteur 1173P2 4698392 YP_977141.1 CDS BCG_1046c NC_008769.1 1138661 1138993 R hypothetical protein complement(1138661..1138993) Mycobacterium bovis BCG str. Pasteur 1173P2 4696238 YP_977142.1 CDS BCG_1047c NC_008769.1 1139067 1139660 R Differs from Rv0992c by 2aa, I3M, S135G, and from Mb1019c by 1aa, S135G; hypothetical protein complement(1139067..1139660) Mycobacterium bovis BCG str. Pasteur 1173P2 4696940 YP_977143.1 CDS galU NC_008769.1 1139761 1140681 D Differs from Rv0993 by 1aa, R235Q; UTP--glucose-1-phosphate uridylyltransferase galU 1139761..1140681 Mycobacterium bovis BCG str. Pasteur 1173P2 4696360 YP_977144.1 CDS moeA1 NC_008769.1 1140758 1142038 D Differs from Rv0994 by 1aa, G230C; molybdopterin biosynthesis protein moeA1 1140758..1142038 Mycobacterium bovis BCG str. Pasteur 1173P2 4695745 YP_977145.1 CDS rimJ NC_008769.1 1142101 1142712 D ribosomal-protein-alanine acetyltransferase rimJ 1142101..1142712 Mycobacterium bovis BCG str. Pasteur 1173P2 4695570 YP_977146.1 CDS BCG_1051 NC_008769.1 1142873 1143949 D Differs from Rv0996 by 1aa, D92G, and from Mb1023 by 1aa, D92G; hypothetical protein 1142873..1143949 Mycobacterium bovis BCG str. Pasteur 1173P2 4695905 YP_977147.1 CDS BCG_1052 NC_008769.1 1144123 1144353 D hypothetical protein 1144123..1144353 Mycobacterium bovis BCG str. Pasteur 1173P2 4697081 YP_977148.1 CDS BCG_1053 NC_008769.1 1144350 1144601 D hypothetical protein 1144350..1144601 Mycobacterium bovis BCG str. Pasteur 1173P2 4696956 YP_977149.1 CDS BCG_1054 NC_008769.1 1144782 1145213 D hypothetical protein 1144782..1145213 Mycobacterium bovis BCG str. Pasteur 1173P2 4696937 YP_977150.1 CDS BCG_1055 NC_008769.1 1145237 1146238 D hypothetical protein 1145237..1146238 Mycobacterium bovis BCG str. Pasteur 1173P2 4695670 YP_977151.1 CDS BCG_1056 NC_008769.1 1146256 1147014 D hypothetical protein 1146256..1147014 Mycobacterium bovis BCG str. Pasteur 1173P2 4696088 YP_977152.1 CDS BCG_1057c NC_008769.1 1147020 1147637 R hypothetical protein complement(1147020..1147637) Mycobacterium bovis BCG str. Pasteur 1173P2 4696684 YP_977153.1 CDS arcA NC_008769.1 1147674 1148882 D catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 1147674..1148882 Mycobacterium bovis BCG str. Pasteur 1173P2 4697140 YP_977154.1 CDS BCG_1059c NC_008769.1 1148917 1150428 R Differs from Rv1002c by 1aa, L115V; hypothetical protein complement(1148917..1150428) Mycobacterium bovis BCG str. Pasteur 1173P2 4695564 YP_977155.1 CDS BCG_1060 NC_008769.1 1150511 1151368 D hypothetical protein 1150511..1151368 Mycobacterium bovis BCG str. Pasteur 1173P2 4696619 YP_977156.1 CDS BCG_1061c NC_008769.1 1151378 1152637 R hypothetical protein complement(1151378..1152637) Mycobacterium bovis BCG str. Pasteur 1173P2 4697035 YP_977157.1 CDS pabB NC_008769.1 1152711 1154147 R catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; aminodeoxychorismate synthase component I complement(1152711..1154147) Mycobacterium bovis BCG str. Pasteur 1173P2 4696043 YP_977158.1 CDS BCG_1063 NC_008769.1 1154203 1155906 D Differs from Rv1006 by 1aa, S535P, and from Mb1033 by 1aa, N25S; hypothetical protein 1154203..1155906 Mycobacterium bovis BCG str. Pasteur 1173P2 4695406 YP_977159.1 CDS metS NC_008769.1 1155933 1157492 R methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase complement(1155933..1157492) Mycobacterium bovis BCG str. Pasteur 1173P2 4695974 YP_977160.1 CDS tatD NC_008769.1 1157578 1158372 D Differs from Rv1008 by 1aa, N186T; deoxyribonuclease TatD (YjjV protein) 1157578..1158372 Mycobacterium bovis BCG str. Pasteur 1173P2 4699105 YP_977161.1 CDS rpfB NC_008769.1 1158580 1159668 D Differs from Rv1009 by 2aa, E282G, V357A; resuscitation-promoting factor rpfB 1158580..1159668 Mycobacterium bovis BCG str. Pasteur 1173P2 4697792 YP_977162.1 CDS ksgA NC_008769.1 1159641 1160594 D catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1159641..1160594 Mycobacterium bovis BCG str. Pasteur 1173P2 4697713 YP_977163.1 CDS ispE NC_008769.1 1160680 1161600 D catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1160680..1161600 Mycobacterium bovis BCG str. Pasteur 1173P2 4696457 YP_977164.1 CDS BCG_1069 NC_008769.1 1161597 1161911 D In Mycobacterium tuberculosis strain H37Rv, Rv1012 exists as a single gene. In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a different NH2 terminus. Differs from Rv1012 by 1aa, N65S; hypothetical protein 1161597..1161911 Mycobacterium bovis BCG str. Pasteur 1173P2 4697436 YP_977165.1 CDS pks16 NC_008769.1 1162115 1163749 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1162115..1163749 Mycobacterium bovis BCG str. Pasteur 1173P2 4695878 YP_977166.1 CDS pth NC_008769.1 1163823 1164398 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(1163823..1164398) Mycobacterium bovis BCG str. Pasteur 1173P2 4698458 YP_977167.1 CDS rplY NC_008769.1 1164411 1165058 R the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 complement(1164411..1165058) Mycobacterium bovis BCG str. Pasteur 1173P2 4697317 YP_977168.1 CDS lpqT NC_008769.1 1165192 1165950 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a 5 bp deletion (cacgc-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; lipoprotein lpqT complement(1165192..1165950) Mycobacterium bovis BCG str. Pasteur 1173P2 4697627 YP_977169.1 CDS prsA NC_008769.1 1165986 1166966 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1165986..1166966) Mycobacterium bovis BCG str. Pasteur 1173P2 4696681 YP_977170.1 CDS glmU NC_008769.1 1167058 1168545 R forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase complement(1167058..1168545) Mycobacterium bovis BCG str. Pasteur 1173P2 4697278 YP_977171.1 CDS BCG_1076 NC_008769.1 1168800 1169393 D TetR family transcriptional regulator 1168800..1169393 Mycobacterium bovis BCG str. Pasteur 1173P2 4696852 YP_977172.1 CDS mfd NC_008769.1 1169452 1173156 D transcription-repair coupling factor mfd 1169452..1173156 Mycobacterium bovis BCG str. Pasteur 1173P2 4696286 YP_977173.1 CDS BCG_1078 NC_008769.1 1173156 1174133 D functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase Era; nucleoside triphosphate pyrophosphohydrolase 1173156..1174133 Mycobacterium bovis BCG str. Pasteur 1173P2 4698999 YP_977174.1 CDS lpqU NC_008769.1 1174221 1174952 D Differs from Rv1022 by 1aa, P33T; lipoprotein lpqU 1174221..1174952 Mycobacterium bovis BCG str. Pasteur 1173P2 4696992 YP_977175.1 CDS eno NC_008769.1 1175049 1176338 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1175049..1176338 Mycobacterium bovis BCG str. Pasteur 1173P2 4696682 YP_977176.1 CDS BCG_1081 NC_008769.1 1176343 1177029 D hypothetical protein 1176343..1177029 Mycobacterium bovis BCG str. Pasteur 1173P2 4697043 YP_977177.1 CDS BCG_1082 NC_008769.1 1177046 1177513 D hypothetical protein 1177046..1177513 Mycobacterium bovis BCG str. Pasteur 1173P2 4697461 YP_977178.1 CDS BCG_1083 NC_008769.1 1177504 1178463 D hypothetical protein 1177504..1178463 Mycobacterium bovis BCG str. Pasteur 1173P2 4696016 YP_977179.1 CDS kdpE NC_008769.1 1178912 1179592 R transcriptional regulatory protein kdpE complement(1178912..1179592) Mycobacterium bovis BCG str. Pasteur 1173P2 4696961 YP_977180.1 CDS kdpD NC_008769.1 1179589 1182171 R Differs from Rv1028c by 3aa, S83P, D295G, S368P, and from Mb1056c by 1aa, S83P; sensor protein kdpD complement(1179589..1182171) Mycobacterium bovis BCG str. Pasteur 1173P2 4695428 YP_977181.1 CDS kdpF NC_008769.1 1182405 1182497 D membrane protein kdpF 1182405..1182497 Mycobacterium bovis BCG str. Pasteur 1173P2 4695427 YP_977182.1 CDS kdpA NC_008769.1 1182497 1184212 D catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 1182497..1184212 Mycobacterium bovis BCG str. Pasteur 1173P2 4696453 YP_977183.1 CDS kdpB NC_008769.1 1184209 1186338 D One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 1184209..1186338 Mycobacterium bovis BCG str. Pasteur 1173P2 4695424 YP_977184.1 CDS kdpC NC_008769.1 1186338 1186907 D one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 1186338..1186907 Mycobacterium bovis BCG str. Pasteur 1173P2 4695425 YP_977185.1 CDS trcS NC_008769.1 1186911 1188440 R two component sensor histidine kinase trcS complement(1186911..1188440) Mycobacterium bovis BCG str. Pasteur 1173P2 4695426 YP_977186.1 CDS trcR NC_008769.1 1188448 1189221 R two component transcriptional regulator trcR complement(1188448..1189221) Mycobacterium bovis BCG str. Pasteur 1173P2 4696820 YP_977187.1 CDS BCG_1092c NC_008769.1 1189403 1189792 R transposase complement(1189403..1189792) Mycobacterium bovis BCG str. Pasteur 1173P2 4696819 YP_977188.1 CDS BCG_1093c NC_008769.1 1189860 1190546 R transposase complement(1189860..1190546) Mycobacterium bovis BCG str. Pasteur 1173P2 4696970 YP_977189.1 CDS BCG_1094c NC_008769.1 1190580 1190918 R IS1560 transposase complement(1190580..1190918) Mycobacterium bovis BCG str. Pasteur 1173P2 4696948 YP_977190.1 CDS esxI NC_008769.1 1191029 1191313 R Differs from Rv1037c by 1aa, L20Q; ESAT-6 like protein 1 complement(1191029..1191313) Mycobacterium bovis BCG str. Pasteur 1173P2 4695988 YP_977191.1 CDS esxJ NC_008769.1 1191340 1191636 R ESAT-6 like protein 2 complement(1191340..1191636) Mycobacterium bovis BCG str. Pasteur 1173P2 4696861 YP_977192.1 CDS PPE15 NC_008769.1 1191782 1192957 R Differs from Rv1039c and Mb1068c by 1aa, K175N; PPE family protein complement(1191782..1192957) Mycobacterium bovis BCG str. Pasteur 1173P2 4696776 YP_977193.1 CDS PE8 NC_008769.1 1193034 1193861 R PE family protein complement(1193034..1193861) Mycobacterium bovis BCG str. Pasteur 1173P2 4697238 YP_977194.1 CDS BCG_1100c NC_008769.1 1195577 1195984 R Differs from Rv1042c by 1aa, E129G; IS like-2 transposase complement(1195577..1195984) Mycobacterium bovis BCG str. Pasteur 1173P2 4696964 YP_977195.1 CDS BCG_1101c NC_008769.1 1196267 1197292 R Differs from Rv1043c by 1aa, T99A, and from Mb1072c by 1aa, G263C; hypothetical protein complement(1196267..1197292) Mycobacterium bovis BCG str. Pasteur 1173P2 4695517 YP_977196.1 CDS BCG_1102 NC_008769.1 1197539 1198162 D hypothetical protein 1197539..1198162 Mycobacterium bovis BCG str. Pasteur 1173P2 4696076 YP_977197.1 CDS BCG_1103 NC_008769.1 1198159 1199040 D Differs from Mb1074 by 1aa, W104G; hypothetical protein 1198159..1199040 Mycobacterium bovis BCG str. Pasteur 1173P2 4696177 YP_977198.1 CDS BCG_1104c NC_008769.1 1199122 1199715 R In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a 1bp insertion, compared to Mycobacterium tuberculosis strains H37Rv, leads to different C-terminus; hypothetical protein complement(1199122..1199715) Mycobacterium bovis BCG str. Pasteur 1173P2 4695976 YP_977199.1 CDS BCG_1105 NC_008769.1 1199910 1201157 D IS1081 transposase 1199910..1201157 Mycobacterium bovis BCG str. Pasteur 1173P2 4696038 YP_977200.1 CDS BCG_1106c NC_008769.1 1201525 1202640 R Differs from Rv1048c and Mb1077c by 2aa, A37D, T173A; hypothetical protein complement(1201525..1202640) Mycobacterium bovis BCG str. Pasteur 1173P2 4696073 YP_977201.1 CDS BCG_1107 NC_008769.1 1202873 1203319 D transcriptional repressor protein 1202873..1203319 Mycobacterium bovis BCG str. Pasteur 1173P2 4696013 YP_977202.1 CDS BCG_1108 NC_008769.1 1203367 1204272 D oxidoreductase 1203367..1204272 Mycobacterium bovis BCG str. Pasteur 1173P2 4696028 YP_977203.1 CDS BCG_1109c NC_008769.1 1204431 1205186 R hypothetical protein complement(1204431..1205186) Mycobacterium bovis BCG str. Pasteur 1173P2 4696519 YP_977204.1 CDS BCG_1110 NC_008769.1 1206209 1206598 D hypothetical protein 1206209..1206598 Mycobacterium bovis BCG str. Pasteur 1173P2 4696520 YP_977205.1 CDS BCG_1111c NC_008769.1 1206497 1206772 R hypothetical protein complement(1206497..1206772) Mycobacterium bovis BCG str. Pasteur 1173P2 4695989 YP_977206.1 CDS BCG_1112 NC_008769.1 1207414 1207728 D integrase 1207414..1207728 Mycobacterium bovis BCG str. Pasteur 1173P2 4696036 YP_977207.1 CDS BCG_1113 NC_008769.1 1207725 1207859 D integrase 1207725..1207859 Mycobacterium bovis BCG str. Pasteur 1173P2 4696668 YP_977208.1 CDS BCG_1114 NC_008769.1 1208114 1208878 D hypothetical protein 1208114..1208878 Mycobacterium bovis BCG str. Pasteur 1173P2 4696752 YP_977209.1 CDS BCG_1115 NC_008769.1 1209882 1211063 D hypothetical protein 1209882..1211063 Mycobacterium bovis BCG str. Pasteur 1173P2 4696150 YP_977210.1 CDS fadD14 NC_008769.1 1211170 1212801 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1211170..1212801 Mycobacterium bovis BCG str. Pasteur 1173P2 4696045 YP_977211.1 CDS BCG_1117 NC_008769.1 1212877 1213941 D hypothetical protein 1212877..1213941 Mycobacterium bovis BCG str. Pasteur 1173P2 4699325 YP_977212.1 CDS BCG_1118 NC_008769.1 1213994 1214467 D hypothetical protein 1213994..1214467 Mycobacterium bovis BCG str. Pasteur 1173P2 4696943 YP_977213.1 CDS BCG_1119 NC_008769.1 1214501 1215364 D hypothetical protein 1214501..1215364 Mycobacterium bovis BCG str. Pasteur 1173P2 4696041 YP_977214.1 CDS BCG_1120 NC_008769.1 1215369 1216226 D hypothetical protein 1215369..1216226 Mycobacterium bovis BCG str. Pasteur 1173P2 4695998 YP_977215.1 CDS BCG_1121c NC_008769.1 1216227 1217309 R hypothetical protein complement(1216227..1217309) Mycobacterium bovis BCG str. Pasteur 1173P2 4695543 YP_977216.1 CDS lpqV NC_008769.1 1217390 1217809 R lipoprotein lpqV complement(1217390..1217809) Mycobacterium bovis BCG str. Pasteur 1173P2 4696969 YP_977217.1 CDS BCG_1123 NC_008769.1 1217921 1218487 D hypothetical protein 1217921..1218487 Mycobacterium bovis BCG str. Pasteur 1173P2 4697728 YP_977218.1 CDS BCG_1124 NC_008769.1 1218484 1218879 D hypothetical protein 1218484..1218879 Mycobacterium bovis BCG str. Pasteur 1173P2 4696912 YP_977219.1 CDS PE_PGRS19 NC_008769.1 1218907 1220922 R In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, 2 deletions each of 3 bp (ccg-* and cgc-*) and a 18 bp insertion leads to a longer product compared to their homolog in Mycobacterium tuberculosis strain H37Rv (671 aa versus 667 aa); PE-PGRS family protein complement(1218907..1220922) Mycobacterium bovis BCG str. Pasteur 1173P2 4696220 YP_977220.1 CDS PE_PGRS20 NC_008769.1 1221255 1223447 R In Mycobacterium bovis, insertions of 717 bp and 192 bp, and a 9 bp (tccgctgcc-*) deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (763 aa versus 463 aa). In Mycobacterium bovis BCG Pasteur a deletion of 99 bp leads to a smaller product compared to the homolog in Mycobacterium bovis (730 aa versus 763 aa); PE-PGRS family protein complement(1221255..1223447) Mycobacterium bovis BCG str. Pasteur 1173P2 4697721 YP_977221.1 CDS BCG_1127c NC_008769.1 1223809 1225572 R Differs from Rv1069c and from Mb1098c by 1aa L481P; hypothetical protein complement(1223809..1225572) Mycobacterium bovis BCG str. Pasteur 1173P2 4697723 YP_977222.1 CDS echA8 NC_008769.1 1225569 1226342 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(1225569..1226342) Mycobacterium bovis BCG str. Pasteur 1173P2 4696909 YP_977223.1 CDS echA9 NC_008769.1 1226354 1227391 R catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; 3-hydroxyisobutyryl-CoA hydrolase complement(1226354..1227391) Mycobacterium bovis BCG str. Pasteur 1173P2 4697680 YP_977224.1 CDS BCG_1130 NC_008769.1 1227578 1228414 D hypothetical protein 1227578..1228414 Mycobacterium bovis BCG str. Pasteur 1173P2 4696676 YP_977225.1 CDS BCG_1131 NC_008769.1 1228530 1229381 D hypothetical protein 1228530..1229381 Mycobacterium bovis BCG str. Pasteur 1173P2 4696933 YP_977226.1 CDS fadA3 NC_008769.1 1229455 1230672 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(1229455..1230672) Mycobacterium bovis BCG str. Pasteur 1173P2 4696979 YP_977227.1 CDS BCG_1133c NC_008769.1 1230725 1231669 R hypothetical protein complement(1230725..1231669) Mycobacterium bovis BCG str. Pasteur 1173P2 4697588 YP_977228.1 CDS lipU NC_008769.1 1232066 1232959 D lipase lipU 1232066..1232959 Mycobacterium bovis BCG str. Pasteur 1173P2 4697610 YP_977229.1 CDS cbs NC_008769.1 1233016 1234410 D cystathionine beta-synthase 1233016..1234410 Mycobacterium bovis BCG str. Pasteur 1173P2 4696906 YP_977230.1 CDS pra NC_008769.1 1234612 1235334 D Differs from Rv1078 by 1aa T171I; hypothetical protein 1234612..1235334 Mycobacterium bovis BCG str. Pasteur 1173P2 4695837 YP_977231.1 CDS metB NC_008769.1 1235366 1236532 D catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 1235366..1236532 Mycobacterium bovis BCG str. Pasteur 1173P2 4696490 YP_977232.1 CDS greA NC_008769.1 1236603 1237097 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(1236603..1237097) Mycobacterium bovis BCG str. Pasteur 1173P2 4698209 YP_977233.1 CDS BCG_1139c NC_008769.1 1237283 1237717 R hypothetical protein complement(1237283..1237717) Mycobacterium bovis BCG str. Pasteur 1173P2 4698393 YP_977234.1 CDS mca NC_008769.1 1237819 1238685 D Mycothiol conjugate amidase Mca 1237819..1238685 Mycobacterium bovis BCG str. Pasteur 1173P2 4696926 YP_977235.1 CDS BCG_1141 NC_008769.1 1238682 1238948 D hypothetical protein 1238682..1238948 Mycobacterium bovis BCG str. Pasteur 1173P2 4695350 YP_977236.1 CDS BCG_1142 NC_008769.1 1238935 1240956 D hypothetical protein 1238935..1240956 Mycobacterium bovis BCG str. Pasteur 1173P2 4695864 YP_977237.1 CDS BCG_1143c NC_008769.1 1241055 1241783 R hemolysin-like protein complement(1241055..1241783) Mycobacterium bovis BCG str. Pasteur 1173P2 4696317 YP_977238.1 CDS BCG_1144 NC_008769.1 1241894 1242682 D Short (C15) chain Z-isoprenyl diphosphate synthase 1241894..1242682 Mycobacterium bovis BCG str. Pasteur 1173P2 4697154 YP_977239.1 CDS PE_PGRS21 NC_008769.1 1242859 1245288 D In Mycobacterium bovis BCG Pasteur, insertions of 144 bp and 3bp, and deletion of 42 bp, lead to a longer product compared to the homolog in Mycobacterium bovis (809 aa versus 774 aa). In Mycobacterium bovis, insertions of 3 bp (*-gcg) and 45 bp, and deletions of 18 bp and 9 bp (ggtggggcc-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (774 aa versus 767 aa); PE-PGRS family protein 1242859..1245288 Mycobacterium bovis BCG str. Pasteur 1173P2 4697531 YP_977240.1 CDS BCG_1146 NC_008769.1 1245465 1245785 D hypothetical protein 1245465..1245785 Mycobacterium bovis BCG str. Pasteur 1173P2 4696632 YP_977241.1 CDS PE9 NC_008769.1 1245938 1246372 D PE family protein 1245938..1246372 Mycobacterium bovis BCG str. Pasteur 1173P2 4697811 YP_977242.1 CDS PE10 NC_008769.1 1246251 1246556 D Differs from Rv1089 and Mb1118 by 1 aa N84T; PE family protein 1246251..1246556 Mycobacterium bovis BCG str. Pasteur 1173P2 4696117 YP_977243.1 CDS celA2a NC_008769.1 1246942 1247046 D cellulase celA2a 1246942..1247046 Mycobacterium bovis BCG str. Pasteur 1173P2 4696008 YP_977244.1 CDS celA2b NC_008769.1 1247024 1247479 D cellulase celA2b 1247024..1247479 Mycobacterium bovis BCG str. Pasteur 1173P2 4697535 YP_977245.1 CDS PE_PGRS22 NC_008769.1 1247894 1250446 D In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 9 bp deletion (ccggcggca-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (850 aa versus 853 aa); PE-PGRS family protein 1247894..1250446 Mycobacterium bovis BCG str. Pasteur 1173P2 4697538 YP_977246.1 CDS coaA NC_008769.1 1250664 1251602 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(1250664..1251602) Mycobacterium bovis BCG str. Pasteur 1173P2 4696633 YP_977247.1 CDS glyA NC_008769.1 1251990 1253270 D catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 1251990..1253270 Mycobacterium bovis BCG str. Pasteur 1173P2 4698605 YP_977248.1 CDS desA2 NC_008769.1 1253375 1254202 D acyl-ACP desaturase 1253375..1254202 Mycobacterium bovis BCG str. Pasteur 1173P2 4697846 YP_977249.1 CDS phoH2 NC_008769.1 1254413 1255714 D phoH-like protein phoH2 1254413..1255714 Mycobacterium bovis BCG str. Pasteur 1173P2 4696846 YP_977250.1 CDS BCG_1156 NC_008769.1 1255801 1256676 D Differs from Rv1096 by 1aa, S272P; glycosyl hydrolase 1255801..1256676 Mycobacterium bovis BCG str. Pasteur 1173P2 4697586 YP_977251.1 CDS BCG_1157c NC_008769.1 1256679 1257560 R Differs from Rv1097c by 1aa, L23P; membrane glycine and proline rich protein complement(1256679..1257560) Mycobacterium bovis BCG str. Pasteur 1173P2 4696746 YP_977252.1 CDS fumC NC_008769.1 1257557 1258981 R class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase complement(1257557..1258981) Mycobacterium bovis BCG str. Pasteur 1173P2 4696665 YP_977253.1 CDS glpX NC_008769.1 1259012 1259998 R type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II complement(1259012..1259998) Mycobacterium bovis BCG str. Pasteur 1173P2 4695503 YP_977254.1 CDS BCG_1160 NC_008769.1 1260099 1260800 D Differs from Rv1100 and Mb1130 by 1aa, P21T; hypothetical protein 1260099..1260800 Mycobacterium bovis BCG str. Pasteur 1173P2 4696837 YP_977255.1 CDS BCG_1161c NC_008769.1 1260807 1261835 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (t-*) leads to a shorter product with a different amino part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Mb1131c by 1 aa, E315D; hypothetical protein complement(1260807..1261835) Mycobacterium bovis BCG str. Pasteur 1173P2 4696152 YP_977256.1 CDS BCG_1162c NC_008769.1 1262075 1262386 R Differs from Rv1102c by 1aa, I65T; hypothetical protein complement(1262075..1262386) Mycobacterium bovis BCG str. Pasteur 1173P2 4696033 YP_977257.1 CDS BCG_1163c NC_008769.1 1262386 1262706 R hypothetical protein complement(1262386..1262706) Mycobacterium bovis BCG str. Pasteur 1173P2 4696941 YP_977258.1 CDS BCG_1164 NC_008769.1 1262716 1263405 D para-nitrobenzyl esterase 1262716..1263405 Mycobacterium bovis BCG str. Pasteur 1173P2 4696973 YP_977259.1 CDS BCG_1165 NC_008769.1 1263726 1264241 D para-nitrobenzyl esterase 1263726..1264241 Mycobacterium bovis BCG str. Pasteur 1173P2 4696711 YP_977260.1 CDS BCG_1166c NC_008769.1 1264259 1265371 R cholesterol dehydrogenase complement(1264259..1265371) Mycobacterium bovis BCG str. Pasteur 1173P2 4695475 YP_977261.1 CDS xseB NC_008769.1 1265381 1265638 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(1265381..1265638) Mycobacterium bovis BCG str. Pasteur 1173P2 4696032 YP_977262.1 CDS xseA NC_008769.1 1265628 1266875 R bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit complement(1265628..1266875) Mycobacterium bovis BCG str. Pasteur 1173P2 4697556 YP_977263.1 CDS BCG_1169c NC_008769.1 1266872 1267510 R Differs from Rv1109c and Mb1139c by 1aa, T147A; hypothetical protein complement(1266872..1267510) Mycobacterium bovis BCG str. Pasteur 1173P2 4697555 YP_977264.1 CDS ispH NC_008769.1 1267600 1268607 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1267600..1268607 Mycobacterium bovis BCG str. Pasteur 1173P2 4696975 YP_977265.1 CDS BCG_1171c NC_008769.1 1268624 1269607 R hypothetical protein complement(1268624..1269607) Mycobacterium bovis BCG str. Pasteur 1173P2 4698306 YP_977266.1 CDS BCG_1172 NC_008769.1 1269670 1270743 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1269670..1270743 Mycobacterium bovis BCG str. Pasteur 1173P2 4696967 YP_977267.1 CDS BCG_1173 NC_008769.1 1270831 1271028 D hypothetical protein 1270831..1271028 Mycobacterium bovis BCG str. Pasteur 1173P2 4695571 YP_977268.1 CDS BCG_1174 NC_008769.1 1271025 1271399 D hypothetical protein 1271025..1271399 Mycobacterium bovis BCG str. Pasteur 1173P2 4696613 YP_977269.1 CDS BCG_1175 NC_008769.1 1271602 1272300 D Differs from Rv1115 by 1aa, P19S; hypothetical protein 1271602..1272300 Mycobacterium bovis BCG str. Pasteur 1173P2 4696287 YP_977270.1 CDS BCG_1176 NC_008769.1 1272418 1272603 D hypothetical protein 1272418..1272603 Mycobacterium bovis BCG str. Pasteur 1173P2 4695378 YP_977271.1 CDS BCG_1177c NC_008769.1 1272530 1272805 R hypothetical protein complement(1272530..1272805) Mycobacterium bovis BCG str. Pasteur 1173P2 4697367 YP_977272.1 CDS BCG_1178 NC_008769.1 1273048 1273371 D hypothetical protein 1273048..1273371 Mycobacterium bovis BCG str. Pasteur 1173P2 4697495 YP_977273.1 CDS BCG_1179c NC_008769.1 1273386 1274246 R hypothetical protein complement(1273386..1274246) Mycobacterium bovis BCG str. Pasteur 1173P2 4697402 YP_977274.1 CDS BCG_1180c NC_008769.1 1274279 1274428 R hypothetical protein complement(1274279..1274428) Mycobacterium bovis BCG str. Pasteur 1173P2 4697498 YP_977275.1 CDS BCG_1181c NC_008769.1 1274425 1274919 R Differs from Mb1151c by 1aa, G53A; hypothetical protein complement(1274425..1274919) Mycobacterium bovis BCG str. Pasteur 1173P2 4697323 YP_977276.1 CDS zwf1 NC_008769.1 1275122 1276522 D catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1275122..1276522 Mycobacterium bovis BCG str. Pasteur 1173P2 4696808 YP_977277.1 CDS gnd2 NC_008769.1 1276544 1277566 D similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; 6-phosphogluconate dehydrogenase 1276544..1277566 Mycobacterium bovis BCG str. Pasteur 1173P2 4695516 YP_977278.1 CDS bpoB NC_008769.1 1277559 1278467 R peroxidase bpoB complement(1277559..1278467) Mycobacterium bovis BCG str. Pasteur 1173P2 4697623 YP_977279.1 CDS ephC NC_008769.1 1278542 1279492 D epoxide hydrolase ephC 1278542..1279492 Mycobacterium bovis BCG str. Pasteur 1173P2 4696158 YP_977280.1 CDS BCG_1186 NC_008769.1 1279497 1280741 D Differs from Rv1125 by 1aa, G101S; hypothetical protein 1279497..1280741 Mycobacterium bovis BCG str. Pasteur 1173P2 4698527 YP_977281.1 CDS BCG_1187c NC_008769.1 1280745 1281350 R hypothetical protein complement(1280745..1281350) Mycobacterium bovis BCG str. Pasteur 1173P2 4696720 YP_977282.1 CDS ppdK NC_008769.1 1281347 1282819 R catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase complement(1281347..1282819) Mycobacterium bovis BCG str. Pasteur 1173P2 4696384 YP_977283.1 CDS BCG_1189c NC_008769.1 1283032 1284387 R Differs from Rv1128c by 1aa, G270E; hypothetical protein complement(1283032..1284387) Mycobacterium bovis BCG str. Pasteur 1173P2 4696159 YP_977284.1 CDS BCG_1190c NC_008769.1 1284489 1285949 R transcriptional regulator protein complement(1284489..1285949) Mycobacterium bovis BCG str. Pasteur 1173P2 4696232 YP_977285.1 CDS BCG_1191 NC_008769.1 1285970 1287550 D Differs from Rv1130 by 2aa, G3D, L10F; hypothetical protein 1285970..1287550 Mycobacterium bovis BCG str. Pasteur 1173P2 4696949 YP_977286.1 CDS gltA1 NC_008769.1 1287547 1288728 D catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; citrate synthase 1287547..1288728 Mycobacterium bovis BCG str. Pasteur 1173P2 4695471 YP_977287.1 CDS BCG_1193 NC_008769.1 1288740 1290470 D Differs from Mb1163 by 1aa, T176M; hypothetical protein 1288740..1290470 Mycobacterium bovis BCG str. Pasteur 1173P2 4696569 YP_977288.1 CDS metE NC_008769.1 1290482 1292761 R catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase complement(1290482..1292761) Mycobacterium bovis BCG str. Pasteur 1173P2 4697809 YP_977289.1 CDS BCG_1195 NC_008769.1 1293337 1293573 D hypothetical protein 1293337..1293573 Mycobacterium bovis BCG str. Pasteur 1173P2 4698211 YP_977290.1 CDS PPE16 NC_008769.1 1293687 1295543 R PPE family protein complement(1293687..1295543) Mycobacterium bovis BCG str. Pasteur 1173P2 4695995 YP_977291.1 CDS BCG_1197 NC_008769.1 1295729 1295971 D acetyl-CoA acetyltransferase 1295729..1295971 Mycobacterium bovis BCG str. Pasteur 1173P2 4697239 YP_977292.1 CDS BCG_1198 NC_008769.1 1296021 1296362 D enoyl-CoA hydratase 1296021..1296362 Mycobacterium bovis BCG str. Pasteur 1173P2 4695856 YP_977293.1 CDS BCG_1199c NC_008769.1 1296502 1296870 R hypothetical protein complement(1296502..1296870) Mycobacterium bovis BCG str. Pasteur 1173P2 4695560 YP_977294.1 CDS BCG_1200c NC_008769.1 1296887 1297903 R oxidoreductase complement(1296887..1297903) Mycobacterium bovis BCG str. Pasteur 1173P2 4695731 YP_977295.1 CDS BCG_1201c NC_008769.1 1297900 1298400 R hypothetical protein complement(1297900..1298400) Mycobacterium bovis BCG str. Pasteur 1173P2 4696236 YP_977296.1 CDS BCG_1202 NC_008769.1 1298762 1299610 D integral membrane protein 1298762..1299610 Mycobacterium bovis BCG str. Pasteur 1173P2 4696591 YP_977297.1 CDS echA11 NC_008769.1 1299618 1300424 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(1299618..1300424) Mycobacterium bovis BCG str. Pasteur 1173P2 4697765 YP_977298.1 CDS echA10 NC_008769.1 1300567 1301373 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(1300567..1301373) Mycobacterium bovis BCG str. Pasteur 1173P2 4698548 YP_977299.1 CDS mcr NC_008769.1 1301477 1302559 D alpha-methylacyl-CoA racemase mcr 1301477..1302559 Mycobacterium bovis BCG str. Pasteur 1173P2 4698163 YP_977300.1 CDS BCG_1206 NC_008769.1 1302571 1303323 D short-chain type dehydrogenase/reductase 1302571..1303323 Mycobacterium bovis BCG str. Pasteur 1173P2 4697639 YP_977301.1 CDS mmpL13 NC_008769.1 1303838 1306183 D In Mycobacterium tuberculosis strain H37Rv, Rv1145 and Rv1146 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-a) at H37Rv position 1273250-1273251 leads to a single product; transmembrane transport protein mmpL13 1303838..1306183 Mycobacterium bovis BCG str. Pasteur 1173P2 4697576 YP_977302.1 CDS BCG_1208 NC_008769.1 1306316 1306966 D hypothetical protein 1306316..1306966 Mycobacterium bovis BCG str. Pasteur 1173P2 4697543 YP_977303.1 CDS BCG_1209c NC_008769.1 1307716 1309164 R Differs from Rv1148c and Mb1179c by 1aa, N354H; hypothetical protein complement(1307716..1309164) Mycobacterium bovis BCG str. Pasteur 1173P2 4697287 YP_977304.1 CDS BCG_1210 NC_008769.1 1309309 1309716 D transposase 1309309..1309716 Mycobacterium bovis BCG str. Pasteur 1173P2 4696207 YP_977305.1 CDS BCG_1212c NC_008769.1 1310320 1311033 R Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase complement(1310320..1311033) Mycobacterium bovis BCG str. Pasteur 1173P2 4696307 YP_977306.1 CDS BCG_1213 NC_008769.1 1311071 1311436 D transcriptional regulatory protein 1311071..1311436 Mycobacterium bovis BCG str. Pasteur 1173P2 4698065 YP_977307.1 CDS omt NC_008769.1 1311414 1312262 R Differs from Rv1153c by 2aa, T36A, G53D; O-methyltransferase omt complement(1311414..1312262) Mycobacterium bovis BCG str. Pasteur 1173P2 4698345 YP_977308.1 CDS BCG_1215c NC_008769.1 1312259 1312900 R Differs from Rv1154c by 1aa, A123T; hypothetical protein complement(1312259..1312900) Mycobacterium bovis BCG str. Pasteur 1173P2 4696327 YP_977309.1 CDS BCG_1216 NC_008769.1 1312845 1313288 D Differs from Rv1155 by 1aa, P115S; hypothetical protein 1312845..1313288 Mycobacterium bovis BCG str. Pasteur 1173P2 4697456 YP_977310.1 CDS BCG_1217 NC_008769.1 1313722 1314309 D hypothetical protein 1313722..1314309 Mycobacterium bovis BCG str. Pasteur 1173P2 4697017 YP_977311.1 CDS BCG_1218c NC_008769.1 1314472 1315515 R Is 24 codons shorter than Rv1157c and Mb1188c due to 72bp deletion at position equivalent to H37Rv, 1283458-1283529. After codon 214; hypothetical protein complement(1314472..1315515) Mycobacterium bovis BCG str. Pasteur 1173P2 4696306 YP_977312.1 CDS BCG_1219c NC_008769.1 1315523 1316206 R hypothetical protein complement(1315523..1316206) Mycobacterium bovis BCG str. Pasteur 1173P2 4695931 YP_977313.1 CDS pimE NC_008769.1 1316336 1317631 D involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis; mannosyltransferase 1316336..1317631 Mycobacterium bovis BCG str. Pasteur 1173P2 4696470 YP_977314.1 CDS phhB NC_008769.1 1317628 1317912 R 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction; pterin-4-alpha-carbinolamine dehydratase complement(1317628..1317912) Mycobacterium bovis BCG str. Pasteur 1173P2 4697181 YP_977315.1 CDS mutT2 NC_008769.1 1317939 1318364 D mutator protein mutT2 1317939..1318364 Mycobacterium bovis BCG str. Pasteur 1173P2 4695685 YP_977316.1 CDS narG NC_008769.1 1318672 1322370 D Differs from Rv1161 by 2aa, L458V, G821D; respiratory nitrate reductase (alpha chain) narG 1318672..1322370 Mycobacterium bovis BCG str. Pasteur 1173P2 4697974 YP_977317.1 CDS narH NC_008769.1 1322409 1324085 D respiratory nitrate reductase subunit beta narH 1322409..1324085 Mycobacterium bovis BCG str. Pasteur 1173P2 4697114 YP_977318.1 CDS narJ NC_008769.1 1324142 1324747 D Differs from Rv1163 and Mb1195 by 1aa, L106P; respiratory nitrate reductase (delta chain) narJ 1324142..1324747 Mycobacterium bovis BCG str. Pasteur 1173P2 4697115 YP_977319.1 CDS narI NC_008769.1 1324750 1325490 D Differs from Rv1164 by 1aa, V200A; respiratory nitrate reductase (gamma chain) narI 1324750..1325490 Mycobacterium bovis BCG str. Pasteur 1173P2 4697117 YP_977320.1 CDS typA NC_008769.1 1325512 1327398 D GTP-binding translation elongation factor typA 1325512..1327398 Mycobacterium bovis BCG str. Pasteur 1173P2 4697116 YP_977321.1 CDS lpqW NC_008769.1 1327496 1329403 D lipoprotein lpqW 1327496..1329403 Mycobacterium bovis BCG str. Pasteur 1173P2 4696862 YP_977322.1 CDS BCG_1229c NC_008769.1 1329431 1330036 R transcriptional regulatory protein complement(1329431..1330036) Mycobacterium bovis BCG str. Pasteur 1173P2 4697729 YP_977323.1 CDS PPE17a NC_008769.1 1330607 1331149 R In Mycobacterium tuberculosis strain H37Rv, PPE17 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and in Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits PPE17 into 2 parts, PPE17a and PPE17b; PPE family protein complement(1330607..1331149) Mycobacterium bovis BCG str. Pasteur 1173P2 4697066 YP_977324.1 CDS PE11 NC_008769.1 1331167 1331469 R PE family protein complement(1331167..1331469) Mycobacterium bovis BCG str. Pasteur 1173P2 4697240 YP_977325.1 CDS mshB NC_008769.1 1331649 1332560 D N-Acetyl-1-D-myo-Inosityl-2-amino-2-deoxy-alpha- D-glucopyranoside deacetylase mshB 1331649..1332560 Mycobacterium bovis BCG str. Pasteur 1173P2 4696009 YP_977326.1 CDS BCG_1234 NC_008769.1 1332652 1333092 D hypothetical protein 1332652..1333092 Mycobacterium bovis BCG str. Pasteur 1173P2 4697735 YP_977327.1 CDS PE12 NC_008769.1 1333100 1334026 R Differs from Rv1172c by 1aa, H133Q; PE family protein complement(1333100..1334026) Mycobacterium bovis BCG str. Pasteur 1173P2 4697052 YP_977328.1 CDS fbiC NC_008769.1 1334276 1336846 D 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; FO synthase 1334276..1336846 Mycobacterium bovis BCG str. Pasteur 1173P2 4696010 YP_977329.1 CDS BCG_1237c NC_008769.1 1336952 1337284 R hypothetical protein complement(1336952..1337284) Mycobacterium bovis BCG str. Pasteur 1173P2 4696563 YP_977330.1 CDS fadH NC_008769.1 1337485 1339509 R Differs from Rv1175c by 3aa, N90T, S210T, S649I; NADPH dependent 2,4-dienoyl-CoA reductase fadH complement(1337485..1339509) Mycobacterium bovis BCG str. Pasteur 1173P2 4696713 YP_977331.1 CDS BCG_1239c NC_008769.1 1339506 1340075 R hypothetical protein complement(1339506..1340075) Mycobacterium bovis BCG str. Pasteur 1173P2 4695681 YP_977332.1 CDS fdxC NC_008769.1 1340288 1340614 D ferredoxin fdxC 1340288..1340614 Mycobacterium bovis BCG str. Pasteur 1173P2 4697460 YP_977333.1 CDS BCG_1241 NC_008769.1 1340647 1341735 D catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; N-succinyldiaminopimelate aminotransferase 1340647..1341735 Mycobacterium bovis BCG str. Pasteur 1173P2 4695361 YP_977334.1 CDS BCG_1242c NC_008769.1 1341763 1344582 R hypothetical protein complement(1341763..1344582) Mycobacterium bovis BCG str. Pasteur 1173P2 4697152 YP_977335.1 CDS pks3 NC_008769.1 1345009 1351266 D In Mycobacterium tuberculosis strain H37Rv, Rv1180 and Rv1181 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transversion (a-c) leads to a single product (similar to other organisms). Differs from Rv1181 by 2aa, A1068D, P1423A; polyketide beta-ketoacyl synthase pks3 1345009..1351266 Mycobacterium bovis BCG str. Pasteur 1173P2 4696765 YP_977336.1 CDS papA3 NC_008769.1 1351319 1352737 D polyketide synthase associated protein papA3 1351319..1352737 Mycobacterium bovis BCG str. Pasteur 1173P2 4698461 YP_977337.1 CDS mmpL10 NC_008769.1 1352804 1355812 D transmembrane transport protein mmpL10 1352804..1355812 Mycobacterium bovis BCG str. Pasteur 1173P2 4698056 YP_977338.1 CDS BCG_1246c NC_008769.1 1355816 1356895 R hypothetical protein complement(1355816..1356895) Mycobacterium bovis BCG str. Pasteur 1173P2 4697540 YP_977339.1 CDS fadD21 NC_008769.1 1357060 1358796 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(1357060..1358796) Mycobacterium bovis BCG str. Pasteur 1173P2 4696740 YP_977340.1 CDS BCG_1248c NC_008769.1 1358973 1360589 R Differs from Rv1186c by 1aa, A207P; hypothetical protein complement(1358973..1360589) Mycobacterium bovis BCG str. Pasteur 1173P2 4696733 YP_977341.1 CDS rocA NC_008769.1 1360674 1362305 D pyrroline-5-carboxylate dehydrogenase rocA 1360674..1362305 Mycobacterium bovis BCG str. Pasteur 1173P2 4697146 YP_977342.1 CDS BCG_1250 NC_008769.1 1362305 1363294 D proline dehydrogenase 1362305..1363294 Mycobacterium bovis BCG str. Pasteur 1173P2 4696319 YP_977343.1 CDS sigI NC_008769.1 1363376 1364581 D member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigI 1363376..1364581 Mycobacterium bovis BCG str. Pasteur 1173P2 4697225 YP_977344.1 CDS BCG_1252 NC_008769.1 1364663 1365490 D hypothetical protein 1364663..1365490 Mycobacterium bovis BCG str. Pasteur 1173P2 4695357 YP_977345.1 CDS fadD36 NC_008769.1 1365530 1366951 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1365530..1366951 Mycobacterium bovis BCG str. Pasteur 1173P2 4697325 YP_977346.1 CDS BCG_1254c NC_008769.1 1366984 1368249 R hypothetical protein complement(1366984..1368249) Mycobacterium bovis BCG str. Pasteur 1173P2 4697148 YP_977347.1 CDS PE13 NC_008769.1 1368725 1369024 D PE family protein 1368725..1369024 Mycobacterium bovis BCG str. Pasteur 1173P2 4695845 YP_977348.1 CDS PPE18 NC_008769.1 1369071 1370243 D In Mycobacterium bovis, a 14 bp to 11 bp substitution leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (390 aa versus 391 aa). Differs extensively from orthologs Mb1228 and Rv1196 due to numerous substitutions and transitions. Region from aa 210 - 260 shows most difference; PPE family protein 1369071..1370243 Mycobacterium bovis BCG str. Pasteur 1173P2 4696011 YP_977349.1 CDS esxK NC_008769.1 1370378 1370674 D Differs from Mb1229 by 1aa, A58T; ESAT-6 like protein 3 1370378..1370674 Mycobacterium bovis BCG str. Pasteur 1173P2 4697067 YP_977350.1 CDS esxL NC_008769.1 1370725 1371009 D Differs from Rv1198 by 1aa, D12A; ESAT-6 like protein 4 1370725..1371009 Mycobacterium bovis BCG str. Pasteur 1173P2 4697763 YP_977351.1 CDS BCG_1259c NC_008769.1 1371077 1372324 R Differs from Rv1199c and Mb1231c by 1aa, G90D; transposase complement(1371077..1372324) Mycobacterium bovis BCG str. Pasteur 1173P2 4697568 YP_977352.1 CDS BCG_1260 NC_008769.1 1372661 1373938 D integral membrane transport protein 1372661..1373938 Mycobacterium bovis BCG str. Pasteur 1173P2 4697241 YP_977353.1 CDS BCG_1261c NC_008769.1 1373935 1374888 R transferase complement(1373935..1374888) Mycobacterium bovis BCG str. Pasteur 1173P2 4696391 YP_977354.1 CDS dapE NC_008769.1 1374979 1376043 D catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; succinyl-diaminopimelate desuccinylase 1374979..1376043 Mycobacterium bovis BCG str. Pasteur 1173P2 4697688 YP_977355.1 CDS BCG_1263c NC_008769.1 1376040 1376624 R hypothetical protein complement(1376040..1376624) Mycobacterium bovis BCG str. Pasteur 1173P2 4697363 YP_977356.1 CDS BCG_1264c NC_008769.1 1376655 1378343 R hypothetical protein complement(1376655..1378343) Mycobacterium bovis BCG str. Pasteur 1173P2 4695538 YP_977357.1 CDS BCG_1265 NC_008769.1 1378438 1379001 D hypothetical protein 1378438..1379001 Mycobacterium bovis BCG str. Pasteur 1173P2 4695724 YP_977358.1 CDS fadD6 NC_008769.1 1379051 1380844 D activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization; long-chain-acyl-CoA synthetase 1379051..1380844 Mycobacterium bovis BCG str. Pasteur 1173P2 4695490 YP_977359.1 CDS folP2 NC_008769.1 1380910 1381866 D dihydropteroate synthase 2 folP2 1380910..1381866 Mycobacterium bovis BCG str. Pasteur 1173P2 4696273 YP_977360.1 CDS BCG_1268 NC_008769.1 1381863 1382837 D glucosyl-3-phosphoglycerate synthase 1381863..1382837 Mycobacterium bovis BCG str. Pasteur 1173P2 4695629 YP_977361.1 CDS BCG_1269 NC_008769.1 1382876 1383244 D hypothetical protein 1382876..1383244 Mycobacterium bovis BCG str. Pasteur 1173P2 4695588 YP_977362.1 CDS tagA NC_008769.1 1383241 1383855 D DNA-3-methyladenine glycosylase i tagA 1383241..1383855 Mycobacterium bovis BCG str. Pasteur 1173P2 4697851 YP_977363.1 CDS BCG_1271 NC_008769.1 1383963 1384190 D hypothetical protein 1383963..1384190 Mycobacterium bovis BCG str. Pasteur 1173P2 4696337 YP_977364.1 CDS BCG_1272c NC_008769.1 1384218 1385381 R Differs from Rv1212c by 2aa, I105V, W340L and from Mb1244c by 1aa, W340L; glycosyl transferase family protein complement(1384218..1385381) Mycobacterium bovis BCG str. Pasteur 1173P2 4697324 YP_977365.1 CDS glgC NC_008769.1 1385556 1386770 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1385556..1386770 Mycobacterium bovis BCG str. Pasteur 1173P2 4696300 YP_977366.1 CDS PE14 NC_008769.1 1387013 1387345 R In Mycobacterium bovis BCG and Mycobacterium tuberculosis strain H37Rv, PE14 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 5 bp deletion (cttgt-*) leads to a diffferent COOH terminus; PE family protein complement(1387013..1387345) Mycobacterium bovis BCG str. Pasteur 1173P2 4696642 YP_977367.1 CDS BCG_1275c NC_008769.1 1387479 1389164 R Differs from Rv1215c by 1aa, S169A; hypothetical protein complement(1387479..1389164) Mycobacterium bovis BCG str. Pasteur 1173P2 4696012 YP_977368.1 CDS BCG_1276c NC_008769.1 1389192 1389866 R integral membrane protein complement(1389192..1389866) Mycobacterium bovis BCG str. Pasteur 1173P2 4698313 YP_977369.1 CDS BCG_1277c NC_008769.1 1389875 1391521 R Differs from Mb1249c by 1aa, A143T; tetronasin-transport integral membrane protein ABC transporter complement(1389875..1391521) Mycobacterium bovis BCG str. Pasteur 1173P2 4696804 YP_977370.1 CDS BCG_1278c NC_008769.1 1391518 1392453 R Differs from Rv1218c by 1aa, R243Q; tetronasin-transport atp-binding protein ABC transporter complement(1391518..1392453) Mycobacterium bovis BCG str. Pasteur 1173P2 4695470 YP_977371.1 CDS BCG_1279c NC_008769.1 1392443 1393081 R Differs from Rv1219c and Mb1251c by 1aa, C113W; transcriptional regulatory protein complement(1392443..1393081) Mycobacterium bovis BCG str. Pasteur 1173P2 4697874 YP_977372.1 CDS BCG_1280c NC_008769.1 1393223 1393870 R methyltransferase complement(1393223..1393870) Mycobacterium bovis BCG str. Pasteur 1173P2 4698811 YP_977373.1 CDS sigE NC_008769.1 1394133 1394906 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence; RNA polymerase sigma factor SigE 1394133..1394906 Mycobacterium bovis BCG str. Pasteur 1173P2 4698250 YP_977374.1 CDS BCG_1282 NC_008769.1 1395064 1395528 D hypothetical protein 1395064..1395528 Mycobacterium bovis BCG str. Pasteur 1173P2 4695817 YP_977375.1 CDS htrA NC_008769.1 1395597 1397183 D Differs from Rv1223 by 2aa, L288F, N445S; serine protease htrA 1395597..1397183 Mycobacterium bovis BCG str. Pasteur 1173P2 4698600 YP_977376.1 CDS tatB NC_008769.1 1397185 1397580 D mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 1397185..1397580 Mycobacterium bovis BCG str. Pasteur 1173P2 4696305 YP_977377.1 CDS BCG_1285c NC_008769.1 1397613 1398443 R hypothetical protein complement(1397613..1398443) Mycobacterium bovis BCG str. Pasteur 1173P2 4697790 YP_977378.1 CDS BCG_1286c NC_008769.1 1398554 1400017 R Differs from Rv1226c by 1aa, A450V; hypothetical protein complement(1398554..1400017) Mycobacterium bovis BCG str. Pasteur 1173P2 4698653 YP_977379.1 CDS BCG_1287c NC_008769.1 1400014 1400547 R hypothetical protein complement(1400014..1400547) Mycobacterium bovis BCG str. Pasteur 1173P2 4697143 YP_977380.1 CDS lpqX NC_008769.1 1400642 1401199 D lipoprotein lpqX 1400642..1401199 Mycobacterium bovis BCG str. Pasteur 1173P2 4699294 YP_977381.1 CDS mrp NC_008769.1 1401499 1402671 R MRP-related protein mrp complement(1401499..1402671) Mycobacterium bovis BCG str. Pasteur 1173P2 4697730 YP_977382.1 CDS BCG_1290c NC_008769.1 1402684 1403919 R Differs from Rv1230c by 2aa, G45S, P97S; hypothetical protein complement(1402684..1403919) Mycobacterium bovis BCG str. Pasteur 1173P2 4698096 YP_977383.1 CDS BCG_1291c NC_008769.1 1404044 1404586 R hypothetical protein complement(1404044..1404586) Mycobacterium bovis BCG str. Pasteur 1173P2 4697015 YP_977384.1 CDS BCG_1292c NC_008769.1 1404583 1405890 R Differs from Rv1232c by 1aa, G149C; hypothetical protein complement(1404583..1405890) Mycobacterium bovis BCG str. Pasteur 1173P2 4696605 YP_977385.1 CDS BCG_1293c NC_008769.1 1405952 1406548 R Differs from Rv1233c by 1aa, D46N; hypothetical protein complement(1405952..1406548) Mycobacterium bovis BCG str. Pasteur 1173P2 4696709 YP_977386.1 CDS BCG_1294 NC_008769.1 1406698 1407225 D hypothetical protein 1406698..1407225 Mycobacterium bovis BCG str. Pasteur 1173P2 4698030 YP_977387.1 CDS lpqY NC_008769.1 1407246 1408652 D sugar-binding lipoprotein lpqY 1407246..1408652 Mycobacterium bovis BCG str. Pasteur 1173P2 4696574 YP_977388.1 CDS sugA NC_008769.1 1408649 1409572 D sugar-transport integral membrane protein ABC transporter sugA 1408649..1409572 Mycobacterium bovis BCG str. Pasteur 1173P2 4697731 YP_977389.1 CDS sugB NC_008769.1 1409577 1410401 D sugar-transport integral membrane protein ABC transporter sugB 1409577..1410401 Mycobacterium bovis BCG str. Pasteur 1173P2 4696768 YP_977390.1 CDS sugC NC_008769.1 1410406 1411587 D sugar-transport ATP-binding protein ABC transporter sugC 1410406..1411587 Mycobacterium bovis BCG str. Pasteur 1173P2 4696769 YP_977391.1 CDS corA NC_008769.1 1411664 1412764 R Differs from Rv1239c by 1aa, E139K, and from Mb1271c by 1aa, H195R; magnesium and cobalt transport transmembrane protein corA complement(1411664..1412764) Mycobacterium bovis BCG str. Pasteur 1173P2 4696770 YP_977392.1 CDS mdh NC_008769.1 1412935 1413924 D catalyzes the oxidation of malate to oxaloacetate; malate dehydrogenase 1412935..1413924 Mycobacterium bovis BCG str. Pasteur 1173P2 4697907 YP_977393.1 CDS BCG_1301 NC_008769.1 1414000 1414260 D hypothetical protein 1414000..1414260 Mycobacterium bovis BCG str. Pasteur 1173P2 4696703 YP_977394.1 CDS BCG_1302 NC_008769.1 1414257 1414688 D hypothetical protein 1414257..1414688 Mycobacterium bovis BCG str. Pasteur 1173P2 4695843 YP_977395.1 CDS PE_PGRS23 NC_008769.1 1414711 1416399 R PE-PGRS family protein complement(1414711..1416399) Mycobacterium bovis BCG str. Pasteur 1173P2 4695699 YP_977396.1 CDS lpqZ NC_008769.1 1416579 1417439 D Differs from Rv1244 by 1aa, K242Q; lipoprotein lpqZ 1416579..1417439 Mycobacterium bovis BCG str. Pasteur 1173P2 4696634 YP_977397.1 CDS BCG_1305c NC_008769.1 1417520 1418350 R short-chain type dehydrogenase/reductase complement(1417520..1418350) Mycobacterium bovis BCG str. Pasteur 1173P2 4697732 YP_977398.1 CDS BCG_1306c NC_008769.1 1418407 1418700 R hypothetical protein complement(1418407..1418700) Mycobacterium bovis BCG str. Pasteur 1173P2 4696354 YP_977399.1 CDS BCG_1307c NC_008769.1 1418697 1418966 R hypothetical protein complement(1418697..1418966) Mycobacterium bovis BCG str. Pasteur 1173P2 4695557 YP_977400.1 CDS kgd NC_008769.1 1419079 1422723 R kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; alpha-ketoglutarate decarboxylase complement(1419079..1422723) Mycobacterium bovis BCG str. Pasteur 1173P2 4697169 YP_977401.1 CDS BCG_1309c NC_008769.1 1422916 1423704 R Differs from Rv1249c by 1aa, T95A; hypothetical protein complement(1422916..1423704) Mycobacterium bovis BCG str. Pasteur 1173P2 4696455 YP_977402.1 CDS BCG_1310 NC_008769.1 1423901 1425640 D Differs from Rv1250 by 1aa, G278R; drug-transport integral membrane protein 1423901..1425640 Mycobacterium bovis BCG str. Pasteur 1173P2 4695776 YP_977403.1 CDS BCG_1311c NC_008769.1 1425543 1428962 R hypothetical protein complement(1425543..1428962) Mycobacterium bovis BCG str. Pasteur 1173P2 4695932 YP_977404.1 CDS lprE NC_008769.1 1429018 1429626 R lipoprotein lprE complement(1429018..1429626) Mycobacterium bovis BCG str. Pasteur 1173P2 4697150 YP_977405.1 CDS deaD NC_008769.1 1429692 1431383 D Differs from Rv1253 by 1aa, V143M; cold-shock dead-box protein a deaD 1429692..1431383 Mycobacterium bovis BCG str. Pasteur 1173P2 4695400 YP_977406.1 CDS BCG_1314 NC_008769.1 1431380 1432531 D acyltransferase 1431380..1432531 Mycobacterium bovis BCG str. Pasteur 1173P2 4696539 YP_977407.1 CDS BCG_1315c NC_008769.1 1432500 1432799 R In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 3007 bp deletion (RD13) leads to the fusion of Rv1257c and Rv1255c, and the deletion of Rv1256c, compared to Mycobacterium tuberculosis strain H37Rv; hypothetical protein complement(1432500..1432799) Mycobacterium bovis BCG str. Pasteur 1173P2 4699303 YP_977408.1 CDS BCG_1316c NC_008769.1 1432796 1434055 R integral membrane transport protein complement(1432796..1434055) Mycobacterium bovis BCG str. Pasteur 1173P2 4697701 YP_977409.1 CDS BCG_1317 NC_008769.1 1434054 1434953 D hypothetical protein 1434054..1434953 Mycobacterium bovis BCG str. Pasteur 1173P2 4697243 YP_977410.1 CDS BCG_1318 NC_008769.1 1434955 1435779 D In Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as a single gene. In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv1260 into 2 parts; oxidoreductase 1434955..1435779 Mycobacterium bovis BCG str. Pasteur 1173P2 4697949 YP_977411.1 CDS BCG_1319 NC_008769.1 1435764 1436072 D In Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium Bovis, a frameshift due to a single base deletion (g-*) splits Rv1260 into 2 parts; oxidoreductase 1435764..1436072 Mycobacterium bovis BCG str. Pasteur 1173P2 4697873 YP_977412.1 CDS BCG_1320c NC_008769.1 1436198 1436647 R hypothetical protein complement(1436198..1436647) Mycobacterium bovis BCG str. Pasteur 1173P2 4698116 YP_977413.1 CDS BCG_1321c NC_008769.1 1436652 1437086 R Differs from Rv1262c by 1aa, R104P; HIT family protein complement(1436652..1437086) Mycobacterium bovis BCG str. Pasteur 1173P2 4699123 YP_977414.1 CDS amiB2 NC_008769.1 1437145 1438533 D catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 1437145..1438533 Mycobacterium bovis BCG str. Pasteur 1173P2 4699249 YP_977415.1 CDS BCG_1323 NC_008769.1 1438608 1439801 D Differs from Rv1264 by 1aa, C204R; adenylyl cyclase 1438608..1439801 Mycobacterium bovis BCG str. Pasteur 1173P2 4695489 YP_977416.1 CDS BCG_1324 NC_008769.1 1439974 1440654 D hypothetical protein 1439974..1440654 Mycobacterium bovis BCG str. Pasteur 1173P2 4699050 YP_977417.1 CDS pknH NC_008769.1 1440674 1442464 R In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, the pknH gene contains several substitutions, transitions and transversions compared to Mycobacterium tuberculosis strain H37Rv. The most significant difference results from a 127 bp to 24 bp substitution that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (596 aa versus 626 aa). Differs from Mb1297c by 2aa, F374L, I396N; transmembrane serine/threonine-protein kinase H pknH complement(1440674..1442464) Mycobacterium bovis BCG str. Pasteur 1173P2 4698961 YP_977418.1 CDS embR NC_008769.1 1442805 1443971 R transcriptional regulatory protein embR complement(1442805..1443971) Mycobacterium bovis BCG str. Pasteur 1173P2 4697523 YP_977419.1 CDS BCG_1327c NC_008769.1 1444282 1444980 R hypothetical protein complement(1444282..1444980) Mycobacterium bovis BCG str. Pasteur 1173P2 4696659 YP_977420.1 CDS BCG_1328c NC_008769.1 1445203 1445577 R hypothetical protein complement(1445203..1445577) Mycobacterium bovis BCG str. Pasteur 1173P2 4698701 YP_977421.1 CDS lprA NC_008769.1 1445638 1446372 R Differs from Mb1301c by 1aa, A134T; lipoprotein lprA complement(1445638..1446372) Mycobacterium bovis BCG str. Pasteur 1173P2 4698743 YP_977422.1 CDS BCG_1330c NC_008769.1 1446585 1446926 R hypothetical protein complement(1446585..1446926) Mycobacterium bovis BCG str. Pasteur 1173P2 4695396 YP_977423.1 CDS BCG_1331c NC_008769.1 1447034 1448929 R drugs-transport transmembrane ATP-binding protein ABC transporter complement(1447034..1448929) Mycobacterium bovis BCG str. Pasteur 1173P2 4698841 YP_977424.1 CDS BCG_1332c NC_008769.1 1448926 1450674 R drugs-transport transmembrane ATP-binding protein ABC transporter complement(1448926..1450674) Mycobacterium bovis BCG str. Pasteur 1173P2 4696292 YP_977425.1 CDS lprB NC_008769.1 1450821 1451378 D Differs from Rv1274 by 1aa, P168L; lipoprotein lprB 1450821..1451378 Mycobacterium bovis BCG str. Pasteur 1173P2 4695465 YP_977426.1 CDS lprC NC_008769.1 1451375 1451917 D lipoprotein lprC 1451375..1451917 Mycobacterium bovis BCG str. Pasteur 1173P2 4695397 YP_977427.1 CDS BCG_1335c NC_008769.1 1452062 1452538 R Differs from Rv1276c by 1aa, S92T; hypothetical protein complement(1452062..1452538) Mycobacterium bovis BCG str. Pasteur 1173P2 4695398 YP_977428.1 CDS BCG_1336 NC_008769.1 1452788 1454041 D hypothetical protein 1452788..1454041 Mycobacterium bovis BCG str. Pasteur 1173P2 4698432 YP_977429.1 CDS BCG_1337 NC_008769.1 1454038 1456665 D hypothetical protein 1454038..1456665 Mycobacterium bovis BCG str. Pasteur 1173P2 4698847 YP_977430.1 CDS BCG_1338 NC_008769.1 1456686 1458272 D dehydrogenase FAD flavoprotein GMC oxidoreductase 1456686..1458272 Mycobacterium bovis BCG str. Pasteur 1173P2 4696661 YP_977431.1 CDS oppA NC_008769.1 1458289 1460064 R periplasmic oligopeptide-binding lipoprotein oppA complement(1458289..1460064) Mycobacterium bovis BCG str. Pasteur 1173P2 4696736 YP_977432.1 CDS oppD NC_008769.1 1460057 1461895 R oligopeptide-transport ATP-binding protein ABC transporter oppD complement(1460057..1461895) Mycobacterium bovis BCG str. Pasteur 1173P2 4698681 YP_977433.1 CDS oppC NC_008769.1 1461892 1462767 R oligopeptide-transport integral membrane protein ABC transporter oppC complement(1461892..1462767) Mycobacterium bovis BCG str. Pasteur 1173P2 4698920 YP_977434.1 CDS oppB NC_008769.1 1462764 1463741 R oligopeptide-transport integral membrane protein ABC transporter oppB complement(1462764..1463741) Mycobacterium bovis BCG str. Pasteur 1173P2 4698683 YP_977435.1 CDS canA NC_008769.1 1463948 1464439 D beta-carbonic anhydrase 1463948..1464439 Mycobacterium bovis BCG str. Pasteur 1173P2 4698682 YP_977436.1 CDS cysD NC_008769.1 1464533 1465531 D with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 1464533..1465531 Mycobacterium bovis BCG str. Pasteur 1173P2 4696696 YP_977437.1 CDS cysN NC_008769.1 1465531 1467375 D in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis; bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase 1465531..1467375 Mycobacterium bovis BCG str. Pasteur 1173P2 4696420 YP_977438.1 CDS BCG_1346 NC_008769.1 1467429 1467914 D hypothetical protein 1467429..1467914 Mycobacterium bovis BCG str. Pasteur 1173P2 4695463 YP_977439.1 CDS BCG_1347 NC_008769.1 1467972 1469189 D In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a 153 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (405 aa versus 456 aa); hypothetical protein 1467972..1469189 Mycobacterium bovis BCG str. Pasteur 1173P2 4698316 YP_977440.1 CDS BCG_1348 NC_008769.1 1469238 1469870 D hypothetical protein 1469238..1469870 Mycobacterium bovis BCG str. Pasteur 1173P2 4697517 YP_977441.1 CDS BCG_1349c NC_008769.1 1470009 1471574 R hypothetical protein complement(1470009..1471574) Mycobacterium bovis BCG str. Pasteur 1173P2 4696653 YP_977442.1 CDS BCG_1350 NC_008769.1 1471585 1471899 D hypothetical protein 1471585..1471899 Mycobacterium bovis BCG str. Pasteur 1173P2 4698674 YP_977443.1 CDS BCG_1351c NC_008769.1 1472026 1472361 R hypothetical protein complement(1472026..1472361) Mycobacterium bovis BCG str. Pasteur 1173P2 4697164 YP_977444.1 CDS argS NC_008769.1 1472906 1474558 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1472906..1474558 Mycobacterium bovis BCG str. Pasteur 1173P2 4697859 YP_977445.1 CDS lysA NC_008769.1 1474555 1475898 D diaminopimelate decarboxylase lysA 1474555..1475898 Mycobacterium bovis BCG str. Pasteur 1173P2 4696626 YP_977446.1 CDS thrA NC_008769.1 1475902 1477227 D catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1475902..1477227 Mycobacterium bovis BCG str. Pasteur 1173P2 4697177 YP_977447.1 CDS thrC NC_008769.1 1477224 1478306 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1477224..1478306 Mycobacterium bovis BCG str. Pasteur 1173P2 4697961 YP_977448.1 CDS thrB NC_008769.1 1478524 1479474 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1478524..1479474 Mycobacterium bovis BCG str. Pasteur 1173P2 4695909 YP_977449.1 CDS rho NC_008769.1 1479731 1481539 D An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 1479731..1481539 Mycobacterium bovis BCG str. Pasteur 1173P2 4697962 YP_977450.1 CDS rpmE NC_008769.1 1481690 1481932 D RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1481690..1481932 Mycobacterium bovis BCG str. Pasteur 1173P2 4696887 YP_977451.1 CDS prfA NC_008769.1 1482022 1483095 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1482022..1483095 Mycobacterium bovis BCG str. Pasteur 1173P2 4696785 YP_977452.1 CDS hemK NC_008769.1 1483092 1484069 D Differs from Mb1332 by 1aa, G121A, and from Rv1300 by 2aa, G121A, C194R; hemk protein hemK 1483092..1484069 Mycobacterium bovis BCG str. Pasteur 1173P2 4697852 YP_977453.1 CDS BCG_1361 NC_008769.1 1484085 1484738 D Differs from Rv1301 by 1aa, Q196P; hypothetical protein 1484085..1484738 Mycobacterium bovis BCG str. Pasteur 1173P2 4698905 YP_977454.1 CDS rfe NC_008769.1 1484822 1486036 D Differs from Rv1302 by 1aa, G357V; undecapaprenyl-phosphate alpha-n-acetylglucosaminyltransferase rfe 1484822..1486036 Mycobacterium bovis BCG str. Pasteur 1173P2 4699362 YP_977455.1 CDS BCG_1363 NC_008769.1 1486293 1486778 D hypothetical protein 1486293..1486778 Mycobacterium bovis BCG str. Pasteur 1173P2 4696798 YP_977456.1 CDS atpB NC_008769.1 1486771 1487523 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 1486771..1487523 Mycobacterium bovis BCG str. Pasteur 1173P2 4697989 YP_977457.1 CDS atpE NC_008769.1 1487572 1487817 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 1487572..1487817 Mycobacterium bovis BCG str. Pasteur 1173P2 4695587 YP_977458.1 CDS atpF NC_008769.1 1487848 1488363 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 1487848..1488363 Mycobacterium bovis BCG str. Pasteur 1173P2 4697968 YP_977459.1 CDS atpH NC_008769.1 1488370 1489710 D produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 1488370..1489710 Mycobacterium bovis BCG str. Pasteur 1173P2 4695616 YP_977460.1 CDS atpA NC_008769.1 1489755 1491404 D produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 1489755..1491404 Mycobacterium bovis BCG str. Pasteur 1173P2 4696200 YP_977461.1 CDS atpG NC_008769.1 1491411 1492328 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 1491411..1492328 Mycobacterium bovis BCG str. Pasteur 1173P2 4696479 YP_977462.1 CDS atpD NC_008769.1 1492368 1493828 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 1492368..1493828 Mycobacterium bovis BCG str. Pasteur 1173P2 4696344 YP_977463.1 CDS atpC NC_008769.1 1493842 1494207 D part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 1493842..1494207 Mycobacterium bovis BCG str. Pasteur 1173P2 4695832 YP_977464.1 CDS BCG_1372 NC_008769.1 1494215 1494649 D In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 2 bp deletion (cg-*) at the 3' end leads to a slightly shorter product compared to Mycobacterium tuberculosis strain H37Rv (144 aa versus 147 aa). Also differs from Rv1312 by 1aa, V3A; hypothetical protein 1494215..1494649 Mycobacterium bovis BCG str. Pasteur 1173P2 4695935 YP_977465.1 CDS BCG_1373c NC_008769.1 1494696 1495427 R In Mycobacterium tuberculosis strain H37Rv, Rv1313c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG, a frameshift due to a 12 bp to 1 bp substitution (cttgtcgtggcc-t) splits Rv1313c into 2 parts; transposase complement(1494696..1495427) Mycobacterium bovis BCG str. Pasteur 1173P2 4697520 YP_977466.1 CDS BCG_1374c NC_008769.1 1495402 1496019 R In Mycobacterium tuberculosis strain H37Rv, Rv1313c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG, a frameshift due to a 12 bp to 1 bp substitution (cttgtcgtggcc-t) splits Rv1313c into 2 parts; transposase complement(1495402..1496019) Mycobacterium bovis BCG str. Pasteur 1173P2 4697513 YP_977467.1 CDS BCG_1375c NC_008769.1 1496185 1496766 R hypothetical protein complement(1496185..1496766) Mycobacterium bovis BCG str. Pasteur 1173P2 4699335 YP_977468.1 CDS murA NC_008769.1 1496835 1498091 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1496835..1498091 Mycobacterium bovis BCG str. Pasteur 1173P2 4697002 YP_977469.1 CDS ogt NC_008769.1 1503648 1504145 R methylated-DNA--protein-cysteine methyltransferase ogt complement(1503648..1504145) Mycobacterium bovis BCG str. Pasteur 1173P2 4698699 YP_977470.1 CDS alkA NC_008769.1 1504142 1505632 R In Mycobacterium bovis BCG Pasteur and Mycobacterium tuberculosis strain H37Rv, alkA exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a premature stop codon that splits alkA into 2 parts, alkAa and alkAb; ada regulatory protein alkA complement(1504142..1505632) Mycobacterium bovis BCG str. Pasteur 1173P2 4696325 YP_977471.1 CDS BCG_1379c NC_008769.1 1505713 1507338 R adenylate cyclase complement(1505713..1507338) Mycobacterium bovis BCG str. Pasteur 1173P2 4697012 YP_977472.1 CDS BCG_1380c NC_008769.1 1507408 1509015 R adenylate cyclase complement(1507408..1509015) Mycobacterium bovis BCG str. Pasteur 1173P2 4698128 YP_977473.1 CDS BCG_1381c NC_008769.1 1509028 1510731 R Differs from Rv1320c by 1aa, A531T; adenylate cyclase complement(1509028..1510731) Mycobacterium bovis BCG str. Pasteur 1173P2 4695618 YP_977474.1 CDS BCG_1382 NC_008769.1 1510793 1511473 D Differs from Rv1321 by 1aa, R144S; hypothetical protein 1510793..1511473 Mycobacterium bovis BCG str. Pasteur 1173P2 4697745 YP_977475.1 CDS BCG_1383 NC_008769.1 1511496 1511792 D hypothetical protein 1511496..1511792 Mycobacterium bovis BCG str. Pasteur 1173P2 4697188 YP_977476.1 CDS BCG_1384c NC_008769.1 1511827 1512285 R hypothetical protein complement(1511827..1512285) Mycobacterium bovis BCG str. Pasteur 1173P2 4699125 YP_977477.1 CDS fadA4 NC_008769.1 1512376 1513545 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 1512376..1513545 Mycobacterium bovis BCG str. Pasteur 1173P2 4695368 YP_977478.1 CDS BCG_1386 NC_008769.1 1513675 1514589 D thioredoxin 1513675..1514589 Mycobacterium bovis BCG str. Pasteur 1173P2 4695371 YP_977479.1 CDS PE_PGRS24 NC_008769.1 1514668 1516479 R Differs from Rv1325c by 1aa, A320T; PE-PGRS family protein complement(1514668..1516479) Mycobacterium bovis BCG str. Pasteur 1173P2 4697594 YP_977480.1 CDS glgB NC_008769.1 1516631 1518826 R catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein complement(1516631..1518826) Mycobacterium bovis BCG str. Pasteur 1173P2 4696635 YP_977481.1 CDS glgE NC_008769.1 1518834 1520939 R glucanase glgE complement(1518834..1520939) Mycobacterium bovis BCG str. Pasteur 1173P2 4696641 YP_977482.1 CDS glgP NC_008769.1 1521078 1523669 D Differs from Rv1328 by 3aa, G532D, F576V, S801A; glycogen phosphorylase glgP 1521078..1523669 Mycobacterium bovis BCG str. Pasteur 1173P2 4696643 YP_977483.1 CDS dinG NC_008769.1 1523709 1525703 R atp-dependent helicase dinG-like protein complement(1523709..1525703) Mycobacterium bovis BCG str. Pasteur 1173P2 4696644 YP_977484.1 CDS BCG_1392c NC_008769.1 1525727 1527073 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1525727..1527073) Mycobacterium bovis BCG str. Pasteur 1173P2 4697149 YP_977485.1 CDS clpS NC_008769.1 1527175 1527480 D involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 1527175..1527480 Mycobacterium bovis BCG str. Pasteur 1173P2 4698747 YP_977486.1 CDS BCG_1394 NC_008769.1 1527440 1528096 D transcriptional regulatory protein 1527440..1528096 Mycobacterium bovis BCG str. Pasteur 1173P2 4698971 YP_977487.1 CDS BCG_1395 NC_008769.1 1528113 1529147 D hydrolase 1528113..1529147 Mycobacterium bovis BCG str. Pasteur 1173P2 4695385 YP_977488.1 CDS BCG_1396 NC_008769.1 1529155 1529595 D hypothetical protein 1529155..1529595 Mycobacterium bovis BCG str. Pasteur 1173P2 4695414 YP_977489.1 CDS BCG_1397 NC_008769.1 1529617 1529898 D antigen cfp10A 1529617..1529898 Mycobacterium bovis BCG str. Pasteur 1173P2 4697211 YP_977490.1 CDS cysM NC_008769.1 1529908 1530879 D cysteine synthase b cysM 1529908..1530879 Mycobacterium bovis BCG str. Pasteur 1173P2 4699313 YP_977491.1 CDS BCG_1399 NC_008769.1 1530870 1531592 D integral membrane protein 1530870..1531592 Mycobacterium bovis BCG str. Pasteur 1173P2 4696745 YP_977492.1 CDS murI NC_008769.1 1531589 1532404 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1531589..1532404 Mycobacterium bovis BCG str. Pasteur 1173P2 4698028 YP_977493.1 CDS BCG_1401 NC_008769.1 1532431 1533252 D hypothetical protein 1532431..1533252 Mycobacterium bovis BCG str. Pasteur 1173P2 4698428 YP_977494.1 CDS rph NC_008769.1 1533269 1534048 D RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 1533269..1534048 Mycobacterium bovis BCG str. Pasteur 1173P2 4699222 YP_977495.1 CDS BCG_1403 NC_008769.1 1534087 1534701 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 1534087..1534701 Mycobacterium bovis BCG str. Pasteur 1173P2 4699112 YP_977496.1 CDS BCG_1404c NC_008769.1 1534698 1535060 R hypothetical protein complement(1534698..1535060) Mycobacterium bovis BCG str. Pasteur 1173P2 4698639 YP_977497.1 CDS lprD NC_008769.1 1535057 1535437 R Differs from Rv1343c by 1aa, A81E; lipoprotein lprD complement(1535057..1535437) Mycobacterium bovis BCG str. Pasteur 1173P2 4699281 YP_977498.1 CDS BCG_1406 NC_008769.1 1535482 1535802 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1535482..1535802 Mycobacterium bovis BCG str. Pasteur 1173P2 4695399 YP_977499.1 CDS fadD33 NC_008769.1 1535795 1537360 D converts medium- to long-chain aliphatic fatty acids into acyl adenylate; involved in mycobactin synthesis; long-chain-fatty-acid--ACP ligase 1535795..1537360 Mycobacterium bovis BCG str. Pasteur 1173P2 4699171 YP_977500.1 CDS fadE14 NC_008769.1 1537360 1538520 D acyl-CoA dehydrogenase fadE14 1537360..1538520 Mycobacterium bovis BCG str. Pasteur 1173P2 4695674 YP_977501.1 CDS BCG_1409c NC_008769.1 1538487 1539119 R hypothetical protein complement(1538487..1539119) Mycobacterium bovis BCG str. Pasteur 1173P2 4697441 YP_977502.1 CDS BCG_1410 NC_008769.1 1539561 1542140 D drugs-transport transmembrane ATP-binding protein ABC transporter 1539561..1542140 Mycobacterium bovis BCG str. Pasteur 1173P2 4696751 YP_977503.1 CDS BCG_1411 NC_008769.1 1542137 1543876 D drugs-transport transmembrane ATP-binding protein ABC transporter 1542137..1543876 Mycobacterium bovis BCG str. Pasteur 1173P2 4699041 YP_977504.1 CDS fabG NC_008769.1 1544005 1544748 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1544005..1544748 Mycobacterium bovis BCG str. Pasteur 1173P2 4698541 YP_977505.1 CDS BCG_1413 NC_008769.1 1544745 1545074 D hypothetical protein 1544745..1545074 Mycobacterium bovis BCG str. Pasteur 1173P2 4697020 YP_977506.1 CDS BCG_1414 NC_008769.1 1545277 1545648 D hypothetical protein 1545277..1545648 Mycobacterium bovis BCG str. Pasteur 1173P2 4697780 YP_977507.1 CDS BCG_1415c NC_008769.1 1545714 1546499 R transcriptional regulatory protein complement(1545714..1546499) Mycobacterium bovis BCG str. Pasteur 1173P2 4698269 YP_977508.1 CDS BCG_1416c NC_008769.1 1546519 1548390 R hypothetical protein complement(1546519..1548390) Mycobacterium bovis BCG str. Pasteur 1173P2 4698124 YP_977509.1 CDS moeY NC_008769.1 1548399 1550546 R Differs from Rv1355c by 1aa (P81L); hypothetical protein complement(1548399..1550546) Mycobacterium bovis BCG str. Pasteur 1173P2 4698468 YP_977510.1 CDS BCG_1418c NC_008769.1 1550543 1551334 R hypothetical protein complement(1550543..1551334) Mycobacterium bovis BCG str. Pasteur 1173P2 4698906 YP_977511.1 CDS BCG_1419c NC_008769.1 1551807 1552730 R Differs from Rv1357c and Mb1392c by 1aa, S276T; hypothetical protein complement(1551807..1552730) Mycobacterium bovis BCG str. Pasteur 1173P2 4696144 YP_977512.1 CDS BCG_1420 NC_008769.1 1553126 1556605 D Differs from Rv1358 by 1aa A442D, and from Mb1393 by 1aa, G31V; transcriptional regulatory protein 1553126..1556605 Mycobacterium bovis BCG str. Pasteur 1173P2 4698127 YP_977513.1 CDS BCG_1421 NC_008769.1 1556687 1557439 D Differs from Mb1394 by 1aa, G187R; transcriptional regulator 1556687..1557439 Mycobacterium bovis BCG str. Pasteur 1173P2 4698526 YP_977514.1 CDS BCG_1422 NC_008769.1 1557862 1558884 D oxidoreductase 1557862..1558884 Mycobacterium bovis BCG str. Pasteur 1173P2 4697931 YP_977515.1 CDS PPE19 NC_008769.1 1558957 1560147 R Differs from Rv1361c by 3aa, Q30K, V55T, P325Q, and more extensively from Mb1396c due to several substitutions, transitions and transversions between codons 158-260; PPE family protein complement(1558957..1560147) Mycobacterium bovis BCG str. Pasteur 1173P2 4698467 YP_977516.1 CDS BCG_1424c NC_008769.1 1560462 1561124 R Differs from Rv1362c by 1aa, G103V; hypothetical protein complement(1560462..1561124) Mycobacterium bovis BCG str. Pasteur 1173P2 4697068 YP_977517.1 CDS BCG_1425c NC_008769.1 1561121 1561906 R Difefrs from Mb1398c by 1aa, T155N; hypothetical protein complement(1561121..1561906) Mycobacterium bovis BCG str. Pasteur 1173P2 4698151 YP_977518.1 CDS BCG_1426c NC_008769.1 1562197 1564158 R Differs from Rv1364c by 2aa, T236A, E465A; hypothetical protein complement(1562197..1564158) Mycobacterium bovis BCG str. Pasteur 1173P2 4695849 YP_977519.1 CDS BCG_1427c NC_008769.1 1564297 1564683 R Differs from Rv1365c by 1aa, K82E; hypothetical protein complement(1564297..1564683) Mycobacterium bovis BCG str. Pasteur 1173P2 4697448 YP_977520.1 CDS BCG_1428 NC_008769.1 1564904 1565725 D hypothetical protein 1564904..1565725 Mycobacterium bovis BCG str. Pasteur 1173P2 4698169 YP_977521.1 CDS BCG_1429c NC_008769.1 1566026 1567159 R Differs from Rv1367c by 1aa, V169I; hypothetical protein complement(1566026..1567159) Mycobacterium bovis BCG str. Pasteur 1173P2 4696298 YP_977522.1 CDS lprF NC_008769.1 1567534 1568319 D lipoprotein lprF 1567534..1568319 Mycobacterium bovis BCG str. Pasteur 1173P2 4698472 YP_977523.1 CDS BCG_1431 NC_008769.1 1568515 1569468 D In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a frameshift due to a single base insertion (*-a) splits Rv1371 into 2 parts, with the latter being the more likely product; hypothetical protein 1568515..1569468 Mycobacterium bovis BCG str. Pasteur 1173P2 4698140 YP_977524.1 CDS BCG_1432 NC_008769.1 1568990 1569985 D In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-a) splits Rv1371 into 2 parts, with the latter being the more likely product. Differs from both Mb1405 and Rv1371 by 1aa, V210I; hypothetical protein 1568990..1569985 Mycobacterium bovis BCG str. Pasteur 1173P2 4698433 YP_977525.1 CDS BCG_1433 NC_008769.1 1569982 1571163 D Differs from Rv1372 and Mb1406 by 2aa, N75K, A101T; hypothetical protein 1569982..1571163 Mycobacterium bovis BCG str. Pasteur 1173P2 4698481 YP_977526.1 CDS BCG_1434 NC_008769.1 1571169 1572152 D In Mycobacterium tuberculosis strain H37Rv, Rv1373 exists as a single gene as is the case in Mycobacterium bovis BCG Pasteur. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits Rv1373 into 2 parts, Mb1407 and Mb1408. Differs from Rv1373 by 2aa, additional P, P155, and L232P; glycolipid sulfotransferase 1571169..1572152 Mycobacterium bovis BCG str. Pasteur 1173P2 4698161 YP_977527.1 CDS BCG_1435c NC_008769.1 1572232 1572690 R Differs from Rv1374c by 1aa, A136T; hypothetical protein complement(1572232..1572690) Mycobacterium bovis BCG str. Pasteur 1173P2 4695444 YP_977528.1 CDS BCG_1436 NC_008769.1 1572992 1574311 D Differs from Rv1375 by 1aa, R86G, and from Mb1410 by 1aa, R322P; hypothetical protein 1572992..1574311 Mycobacterium bovis BCG str. Pasteur 1173P2 4696600 YP_977529.1 CDS BCG_1437 NC_008769.1 1574308 1575801 D Differs from Rv1376 by 1aa, P236R; hypothetical protein 1574308..1575801 Mycobacterium bovis BCG str. Pasteur 1173P2 4695554 YP_977530.1 CDS BCG_1438c NC_008769.1 1575739 1576377 R transferase complement(1575739..1576377) Mycobacterium bovis BCG str. Pasteur 1173P2 4695539 YP_977531.1 CDS BCG_1439c NC_008769.1 1576388 1577815 R Differs from Rv1378c by 1aa, W37R, and from Mb1413c by 1aa, R9H; hypothetical protein complement(1576388..1577815) Mycobacterium bovis BCG str. Pasteur 1173P2 4697515 YP_977532.1 CDS pyrR NC_008769.1 1577814 1578395 D regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 1577814..1578395 Mycobacterium bovis BCG str. Pasteur 1173P2 4698109 YP_977533.1 CDS pyrB NC_008769.1 1578392 1579351 D catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 1578392..1579351 Mycobacterium bovis BCG str. Pasteur 1173P2 4697788 YP_977534.1 CDS pyrC NC_008769.1 1579348 1580640 D catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1579348..1580640 Mycobacterium bovis BCG str. Pasteur 1173P2 4696883 YP_977535.1 CDS BCG_1443 NC_008769.1 1580637 1581134 D export or membrane protein 1580637..1581134 Mycobacterium bovis BCG str. Pasteur 1173P2 4696884 YP_977536.1 CDS carA NC_008769.1 1581131 1582261 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1581131..1582261 Mycobacterium bovis BCG str. Pasteur 1173P2 4697438 YP_977537.1 CDS carB NC_008769.1 1582261 1585608 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1582261..1585608 Mycobacterium bovis BCG str. Pasteur 1173P2 4695811 YP_977538.1 CDS pyrF NC_008769.1 1585605 1586429 D type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1585605..1586429 Mycobacterium bovis BCG str. Pasteur 1173P2 4695581 YP_977539.1 CDS PE15 NC_008769.1 1586624 1586932 D PE family protein 1586624..1586932 Mycobacterium bovis BCG str. Pasteur 1173P2 4697785 YP_977540.1 CDS PPE20 NC_008769.1 1586929 1588548 D Differs from Rv1387 by 1aa, A94V; PPE family protein 1586929..1588548 Mycobacterium bovis BCG str. Pasteur 1173P2 4699005 YP_977541.1 CDS mihF NC_008769.1 1588854 1589426 D integration host factor mihF 1588854..1589426 Mycobacterium bovis BCG str. Pasteur 1173P2 4697070 YP_977542.1 CDS gmk NC_008769.1 1589561 1590187 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1589561..1590187 Mycobacterium bovis BCG str. Pasteur 1173P2 4699003 YP_977543.1 CDS rpoZ NC_008769.1 1590253 1590585 D Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1590253..1590585 Mycobacterium bovis BCG str. Pasteur 1173P2 4697621 YP_977544.1 CDS dfp NC_008769.1 1590601 1591857 D catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 1590601..1591857 Mycobacterium bovis BCG str. Pasteur 1173P2 4696377 YP_977545.1 CDS metK NC_008769.1 1591985 1593196 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1591985..1593196 Mycobacterium bovis BCG str. Pasteur 1173P2 4699155 YP_977546.1 CDS BCG_1454c NC_008769.1 1593269 1594747 R monoxygenase complement(1593269..1594747) Mycobacterium bovis BCG str. Pasteur 1173P2 4699104 YP_977547.1 CDS cyp132 NC_008769.1 1594744 1596129 R Differs from Rv1394c by 1aa, L135R; cytochrome P450 132 cyp132 complement(1594744..1596129) Mycobacterium bovis BCG str. Pasteur 1173P2 4698454 YP_977548.1 CDS BCG_1456 NC_008769.1 1596207 1597241 D transcriptional regulatory protein 1596207..1597241 Mycobacterium bovis BCG str. Pasteur 1173P2 4695410 YP_977549.1 CDS PE_PGRS25 NC_008769.1 1597287 1598645 R In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a 372 bp deletion leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (452 aa versus 576 aa).Differs from Rv1396c by 2aa, S66R, H300R; PE-PGRS family protein complement(1597287..1598645) Mycobacterium bovis BCG str. Pasteur 1173P2 4695915 YP_977550.1 CDS BCG_1458c NC_008769.1 1598900 1599301 R Differs from Rv1397c by 1aa, G103D; hypothetical protein complement(1598900..1599301) Mycobacterium bovis BCG str. Pasteur 1173P2 4696636 YP_977551.1 CDS BCG_1459c NC_008769.1 1599298 1599555 R hypothetical protein complement(1599298..1599555) Mycobacterium bovis BCG str. Pasteur 1173P2 4697834 YP_977552.1 CDS lipH NC_008769.1 1599638 1600597 R Differs from Rv1399c and Mb1434c by 1aa, A46P; lipase lipH complement(1599638..1600597) Mycobacterium bovis BCG str. Pasteur 1173P2 4698003 YP_977553.1 CDS lipI NC_008769.1 1600622 1601584 R lipase lipH complement(1600622..1601584) Mycobacterium bovis BCG str. Pasteur 1173P2 4698087 YP_977554.1 CDS BCG_1462 NC_008769.1 1601718 1602320 D hypothetical protein 1601718..1602320 Mycobacterium bovis BCG str. Pasteur 1173P2 4698088 YP_977555.1 CDS priA NC_008769.1 1602401 1604368 D binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 1602401..1604368 Mycobacterium bovis BCG str. Pasteur 1173P2 4695896 YP_977556.1 CDS BCG_1464c NC_008769.1 1604386 1605210 R methyltransferase complement(1604386..1605210) Mycobacterium bovis BCG str. Pasteur 1173P2 4697854 YP_977557.1 CDS BCG_1465 NC_008769.1 1605379 1605861 D transcriptional regulatory protein 1605379..1605861 Mycobacterium bovis BCG str. Pasteur 1173P2 4695861 YP_977558.1 CDS BCG_1466c NC_008769.1 1605933 1606757 R methyltransferase complement(1605933..1606757) Mycobacterium bovis BCG str. Pasteur 1173P2 4697183 YP_977559.1 CDS fmt NC_008769.1 1606954 1607892 D modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1606954..1607892 Mycobacterium bovis BCG str. Pasteur 1173P2 4695478 YP_977560.1 CDS fmu NC_008769.1 1607889 1609262 D Differs from Rv1407 by 1aa, L427I; fmu protein 1607889..1609262 Mycobacterium bovis BCG str. Pasteur 1173P2 4697984 YP_977561.1 CDS rpe NC_008769.1 1609287 1609985 D catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 1609287..1609985 Mycobacterium bovis BCG str. Pasteur 1173P2 4697985 YP_977562.1 CDS ribG NC_008769.1 1609982 1611001 D Differs from Rv1409 by 2aa, N30K, T71A; bifunctional riboflavin biosynthesis protein RIBG: diaminohydroxyphosphoribosylaminopyrimidine deaminase + 5-amino-6-(5-phosphoribosylamino) uracil reductase 1609982..1611001 Mycobacterium bovis BCG str. Pasteur 1173P2 4697711 YP_977563.1 CDS BCG_1471c NC_008769.1 1610998 1612554 R aminoglycosides/tetracycline-transport integral membrane protein complement(1610998..1612554) Mycobacterium bovis BCG str. Pasteur 1173P2 4695902 YP_977564.1 CDS lprG NC_008769.1 1612560 1613270 R lipoprotein lprG complement(1612560..1613270) Mycobacterium bovis BCG str. Pasteur 1173P2 4696284 YP_977565.1 CDS ribC NC_008769.1 1613355 1613960 D catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1613355..1613960 Mycobacterium bovis BCG str. Pasteur 1173P2 4698141 YP_977566.1 CDS BCG_1474 NC_008769.1 1614174 1614689 D hypothetical protein 1614174..1614689 Mycobacterium bovis BCG str. Pasteur 1173P2 4696890 YP_977567.1 CDS BCG_1475 NC_008769.1 1614679 1615080 D hypothetical protein 1614679..1615080 Mycobacterium bovis BCG str. Pasteur 1173P2 4695387 YP_977568.1 CDS ribA2 NC_008769.1 1615185 1616462 D bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein 1615185..1616462 Mycobacterium bovis BCG str. Pasteur 1173P2 4696694 YP_977569.1 CDS ribH NC_008769.1 1616477 1616941 D RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 1616477..1616941 Mycobacterium bovis BCG str. Pasteur 1173P2 4696889 YP_977570.1 CDS BCG_1478 NC_008769.1 1616938 1617402 D hypothetical protein 1616938..1617402 Mycobacterium bovis BCG str. Pasteur 1173P2 4695903 YP_977571.1 CDS lprH NC_008769.1 1617427 1618113 D lipoprotein lprH 1617427..1618113 Mycobacterium bovis BCG str. Pasteur 1173P2 4698067 YP_977572.1 CDS BCG_1480 NC_008769.1 1618293 1618766 D hypothetical protein 1618293..1618766 Mycobacterium bovis BCG str. Pasteur 1173P2 4698142 YP_977573.1 CDS uvrC NC_008769.1 1618830 1620770 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1618830..1620770 Mycobacterium bovis BCG str. Pasteur 1173P2 4696648 YP_977574.1 CDS BCG_1482 NC_008769.1 1620767 1621672 D hypothetical protein 1620767..1621672 Mycobacterium bovis BCG str. Pasteur 1173P2 4697228 YP_977575.1 CDS BCG_1483 NC_008769.1 1621669 1622697 D Differs from Mb1457 by 1aa, A86V; hypothetical protein 1621669..1622697 Mycobacterium bovis BCG str. Pasteur 1173P2 4696789 YP_977576.1 CDS whiA NC_008769.1 1622694 1623671 D transcriptional regulatory protein whiA 1622694..1623671 Mycobacterium bovis BCG str. Pasteur 1173P2 4697212 YP_977577.1 CDS BCG_1485c NC_008769.1 1623681 1624442 R hypothetical protein complement(1623681..1624442) Mycobacterium bovis BCG str. Pasteur 1173P2 4695496 YP_977578.1 CDS BCG_1486 NC_008769.1 1624446 1625825 D Differs from Rv1425 by 1aa, L343P; hypothetical protein 1624446..1625825 Mycobacterium bovis BCG str. Pasteur 1173P2 4697619 YP_977579.1 CDS lipO NC_008769.1 1625847 1627109 R esterase lipO complement(1625847..1627109) Mycobacterium bovis BCG str. Pasteur 1173P2 4697478 YP_977580.1 CDS fadD12 NC_008769.1 1627109 1628716 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(1627109..1628716) Mycobacterium bovis BCG str. Pasteur 1173P2 4698636 YP_977581.1 CDS BCG_1489c NC_008769.1 1628720 1629547 R hypothetical protein complement(1628720..1629547) Mycobacterium bovis BCG str. Pasteur 1173P2 4696070 YP_977582.1 CDS BCG_1490 NC_008769.1 1629666 1630934 D hypothetical protein 1629666..1630934 Mycobacterium bovis BCG str. Pasteur 1173P2 4696689 YP_977583.1 CDS PE16 NC_008769.1 1631174 1632760 D PE family protein 1631174..1632760 Mycobacterium bovis BCG str. Pasteur 1173P2 4696558 YP_977584.1 CDS BCG_1492 NC_008769.1 1632871 1634640 D Differs from Rv1431 by 2aa, T65N, Q455K; hypothetical protein 1632871..1634640 Mycobacterium bovis BCG str. Pasteur 1173P2 4699006 YP_977585.1 CDS BCG_1493 NC_008769.1 1634637 1636058 D dehydrogenase 1634637..1636058 Mycobacterium bovis BCG str. Pasteur 1173P2 4697497 YP_977586.1 CDS BCG_1494 NC_008769.1 1636222 1637043 D Differs from Rv1433 and Mb1468 at C-terminal end due to 1bp deletion at position equivalent to H37Rv 1612222-1612222; hypothetical protein 1636222..1637043 Mycobacterium bovis BCG str. Pasteur 1173P2 4695641 YP_977587.1 CDS BCG_1495 NC_008769.1 1637043 1637180 D hypothetical protein 1637043..1637180 Mycobacterium bovis BCG str. Pasteur 1173P2 4697005 YP_977588.1 CDS BCG_1496c NC_008769.1 1637129 1637758 R In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, an in-frame insertion of 21 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (209 aa versus 202 aa). Differs from Rv1435c by 1aa, T67A; hypothetical protein complement(1637129..1637758) Mycobacterium bovis BCG str. Pasteur 1173P2 4696727 YP_977589.1 CDS gap NC_008769.1 1638115 1639134 D glyceraldehyde 3-phosphate dehydrogenase gap 1638115..1639134 Mycobacterium bovis BCG str. Pasteur 1173P2 4695593 YP_977590.1 CDS pgk NC_008769.1 1639137 1640375 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 1639137..1640375 Mycobacterium bovis BCG str. Pasteur 1173P2 4695746 YP_977591.1 CDS tpiA NC_008769.1 1640372 1641157 D Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1640372..1641157 Mycobacterium bovis BCG str. Pasteur 1173P2 4698546 YP_977592.1 CDS BCG_1500c NC_008769.1 1641769 1642194 R hypothetical protein complement(1641769..1642194) Mycobacterium bovis BCG str. Pasteur 1173P2 4696389 YP_977593.1 CDS secG NC_008769.1 1642645 1642878 D preprotein translocase subunit SecG 1642645..1642878 Mycobacterium bovis BCG str. Pasteur 1173P2 4696624 YP_977594.1 CDS PE_PGRS26 NC_008769.1 1643017 1644492 R Differs from Rv1441c by 1aa G236D and from Mb1476c by 1aa T354N; PE-PGRS family protein complement(1643017..1644492) Mycobacterium bovis BCG str. Pasteur 1173P2 4697880 YP_977595.1 CDS bisC NC_008769.1 1644599 1646899 D biotin sulfoxide reductase bisC 1644599..1646899 Mycobacterium bovis BCG str. Pasteur 1173P2 4696178 YP_977596.1 CDS BCG_1504c NC_008769.1 1647015 1647500 R hypothetical protein complement(1647015..1647500) Mycobacterium bovis BCG str. Pasteur 1173P2 4695781 YP_977597.1 CDS BCG_1505c NC_008769.1 1648099 1648509 R hypothetical protein complement(1648099..1648509) Mycobacterium bovis BCG str. Pasteur 1173P2 4696240 YP_977598.1 CDS devB NC_008769.1 1648526 1649269 R 6-phosphogluconolactonase devB complement(1648526..1649269) Mycobacterium bovis BCG str. Pasteur 1173P2 4697569 YP_977599.1 CDS opcA NC_008769.1 1649266 1650177 R Differs from Rv1446v by 1aa P192R; OXPP cycle protein opcA complement(1649266..1650177) Mycobacterium bovis BCG str. Pasteur 1173P2 4698619 YP_977600.1 CDS zwf2 NC_008769.1 1650230 1651774 R catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase complement(1650230..1651774) Mycobacterium bovis BCG str. Pasteur 1173P2 4698679 YP_977601.1 CDS tal NC_008769.1 1651771 1652892 R catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase complement(1651771..1652892) Mycobacterium bovis BCG str. Pasteur 1173P2 4695914 YP_977602.1 CDS tkt NC_008769.1 1652909 1655011 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(1652909..1655011) Mycobacterium bovis BCG str. Pasteur 1173P2 4696338 YP_977603.1 CDS PE_PGRS27 NC_008769.1 1655450 1659649 R In Mycobacterium bovis, insertions of 27 bp, 207 bp and 27 bp, substitutions of 60 bp to 63 bp and 11 bp, and a 27 bp deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (1408 aa versus 1329 aa). In Mycobacterium bovis BCG Pasteur one 27bp-insertion is missing, leading to a product of 1399 aa; PE-PGRS family protein complement(1655450..1659649) Mycobacterium bovis BCG str. Pasteur 1173P2 4695913 YP_977604.1 CDS ctaB NC_008769.1 1660051 1660977 D converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 1660051..1660977 Mycobacterium bovis BCG str. Pasteur 1173P2 4696179 YP_977605.1 CDS PE_PGRS28 NC_008769.1 1661026 1663248 R In Mycobacterium bovis BCG Pasteur, a insertion of 51 bp, several substitutions and a deletion of 207 bp, lead to a smaller product compared to its homolog Mycobacterium bovis (740 aa versus 795 aa); PE-PGRS family protein complement(1661026..1663248) Mycobacterium bovis BCG str. Pasteur 1173P2 4697935 YP_977606.1 CDS BCG_1514 NC_008769.1 1663400 1664665 D Differs from Rv1453 by 1aa Q405P; transcriptional activator protein 1663400..1664665 Mycobacterium bovis BCG str. Pasteur 1173P2 4696180 YP_977607.1 CDS qor NC_008769.1 1664693 1665679 R quinone reductase qor complement(1664693..1665679) Mycobacterium bovis BCG str. Pasteur 1173P2 4697000 YP_977608.1 CDS BCG_1516 NC_008769.1 1665699 1666562 D hypothetical protein 1665699..1666562 Mycobacterium bovis BCG str. Pasteur 1173P2 4695435 YP_977609.1 CDS BCG_1517c NC_008769.1 1666512 1667444 R unidentified antibiotic-transport integral membrane ABC transporter complement(1666512..1667444) Mycobacterium bovis BCG str. Pasteur 1173P2 4697458 YP_977610.1 CDS BCG_1518c NC_008769.1 1667556 1668341 R unidentified antibiotic-transport integral membrane ABC transporter complement(1667556..1668341) Mycobacterium bovis BCG str. Pasteur 1173P2 4697566 YP_977611.1 CDS BCG_1519c NC_008769.1 1668338 1669279 R unidentified antibiotic-transport ATP-binding protein ABC transporter complement(1668338..1669279) Mycobacterium bovis BCG str. Pasteur 1173P2 4698819 YP_977612.1 CDS BCG_1520c NC_008769.1 1669435 1671210 R Differs from Rv1459c by 1aa, E113K; hypothetical protein complement(1669435..1671210) Mycobacterium bovis BCG str. Pasteur 1173P2 4695558 YP_977613.1 CDS BCG_1521 NC_008769.1 1671258 1672064 D Differs from Rv1460 by 2aa, F198I, V265 and from Mb1495 by 1aa, F198I; transcriptional regulatory protein 1671258..1672064 Mycobacterium bovis BCG str. Pasteur 1173P2 4698980 YP_977614.1 CDS BCG_1522 NC_008769.1 1672061 1674601 D hypothetical protein 1672061..1674601 Mycobacterium bovis BCG str. Pasteur 1173P2 4696064 YP_977615.1 CDS BCG_1523 NC_008769.1 1674598 1675791 D Differs from Rv1462 by 1aa, D183N; hypothetical protein 1674598..1675791 Mycobacterium bovis BCG str. Pasteur 1173P2 4697462 YP_977616.1 CDS BCG_1524 NC_008769.1 1675788 1676588 D ABC transporter ATP-binding protein 1675788..1676588 Mycobacterium bovis BCG str. Pasteur 1173P2 4697207 YP_977617.1 CDS csd NC_008769.1 1676590 1677843 D cysteine desulfurase csd 1676590..1677843 Mycobacterium bovis BCG str. Pasteur 1173P2 4695676 YP_977618.1 CDS BCG_1526 NC_008769.1 1677840 1678328 D nitrogen fixation-like protein 1677840..1678328 Mycobacterium bovis BCG str. Pasteur 1173P2 4697983 YP_977619.1 CDS BCG_1527 NC_008769.1 1678303 1678650 D hypothetical protein 1678303..1678650 Mycobacterium bovis BCG str. Pasteur 1173P2 4696091 YP_977620.1 CDS fadE15 NC_008769.1 1678745 1680574 R acyl-CoA dehydrogenase fadE15 complement(1678745..1680574) Mycobacterium bovis BCG str. Pasteur 1173P2 4698487 YP_977621.1 CDS PE_PGRS29 NC_008769.1 1680681 1681793 R PE-PGRS family protein complement(1680681..1681793) Mycobacterium bovis BCG str. Pasteur 1173P2 4697442 YP_977622.1 CDS ctpD NC_008769.1 1682035 1684008 D cation transporter P-type atpase D ctpD 1682035..1684008 Mycobacterium bovis BCG str. Pasteur 1173P2 4696181 YP_977623.1 CDS trxA NC_008769.1 1684052 1684426 D thioredoxin trxA 1684052..1684426 Mycobacterium bovis BCG str. Pasteur 1173P2 4696169 YP_977624.1 CDS trxB1 NC_008769.1 1684442 1684813 D thioredoxin trxB1 1684442..1684813 Mycobacterium bovis BCG str. Pasteur 1173P2 4696831 YP_977625.1 CDS echA12 NC_008769.1 1684835 1685692 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1684835..1685692 Mycobacterium bovis BCG str. Pasteur 1173P2 4696832 YP_977626.1 CDS BCG_1534 NC_008769.1 1685728 1687356 D macrolide-transport ATP-binding protein ABC transporter 1685728..1687356 Mycobacterium bovis BCG str. Pasteur 1173P2 4697215 YP_977627.1 CDS BCG_1535 NC_008769.1 1687453 1687644 D Differs from Rv1473A by 1aa, P60S; transcriptional regulatory protein 1687453..1687644 Mycobacterium bovis BCG str. Pasteur 1173P2 4697105 YP_977628.1 CDS BCG_1536c NC_008769.1 1687713 1688276 R transcriptional regulatory protein complement(1687713..1688276) Mycobacterium bovis BCG str. Pasteur 1173P2 4696608 YP_977629.1 CDS acn NC_008769.1 1688287 1691118 R Catalyzes the conversion of citrate to isocitrate; aconitate hydratase complement(1688287..1691118) Mycobacterium bovis BCG str. Pasteur 1173P2 4696216 YP_977630.1 CDS BCG_1538 NC_008769.1 1691276 1691836 D hypothetical protein 1691276..1691836 Mycobacterium bovis BCG str. Pasteur 1173P2 4699040 YP_977631.1 CDS BCG_1539 NC_008769.1 1692062 1693480 D invasion protein 1692062..1693480 Mycobacterium bovis BCG str. Pasteur 1173P2 4696675 YP_977632.1 CDS BCG_1540 NC_008769.1 1693491 1694216 D invasion protein 1693491..1694216 Mycobacterium bovis BCG str. Pasteur 1173P2 4695541 YP_977633.1 CDS moxR1 NC_008769.1 1694355 1695488 D transcriptional regulatory protein moxR1 1694355..1695488 Mycobacterium bovis BCG str. Pasteur 1173P2 4695472 YP_977634.1 CDS BCG_1542 NC_008769.1 1695485 1696438 D hypothetical protein 1695485..1696438 Mycobacterium bovis BCG str. Pasteur 1173P2 4698908 YP_977635.1 CDS BCG_1543 NC_008769.1 1696449 1697456 D Differs from Rv1481 and Mb1517 by 1aa, D254N; hypothetical protein 1696449..1697456 Mycobacterium bovis BCG str. Pasteur 1173P2 4696094 YP_977636.1 CDS BCG_1544c NC_008769.1 1697529 1698371 R hypothetical protein complement(1697529..1698371) Mycobacterium bovis BCG str. Pasteur 1173P2 4696075 YP_977637.1 CDS fabG1 NC_008769.1 1698512 1699255 D 3-oxoacyl-ACP reductase 1698512..1699255 Mycobacterium bovis BCG str. Pasteur 1173P2 4696269 YP_977638.1 CDS inhA NC_008769.1 1699274 1700083 D Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 1699274..1700083 Mycobacterium bovis BCG str. Pasteur 1173P2 4696660 YP_977639.1 CDS hemH NC_008769.1 1700089 1701123 D protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 1700089..1701123 Mycobacterium bovis BCG str. Pasteur 1173P2 4697076 YP_977640.1 CDS BCG_1548c NC_008769.1 1700985 1701956 R First 270 aa identical to Mb1522c and Rv1486c (but differs by 1aa, N198K), then frameshifts due to extra base, g, at position equivalent to Mycobacterium tuberculosis strain H37Rv position 1676073-1676074; hypothetical protein complement(1700985..1701956) Mycobacterium bovis BCG str. Pasteur 1173P2 4698932 YP_977641.1 CDS BCG_1549 NC_008769.1 1702014 1702448 D hypothetical protein 1702014..1702448 Mycobacterium bovis BCG str. Pasteur 1173P2 4697672 YP_977642.1 CDS BCG_1550 NC_008769.1 1702470 1703615 D hypothetical protein 1702470..1703615 Mycobacterium bovis BCG str. Pasteur 1173P2 4697530 YP_977643.1 CDS BCG_1551 NC_008769.1 1703625 1703981 D hypothetical protein 1703625..1703981 Mycobacterium bovis BCG str. Pasteur 1173P2 4696581 YP_977644.1 CDS BCG_1552 NC_008769.1 1704015 1704245 D hypothetical protein 1704015..1704245 Mycobacterium bovis BCG str. Pasteur 1173P2 4697027 YP_977645.1 CDS BCG_1553 NC_008769.1 1704395 1705702 D hypothetical protein 1704395..1705702 Mycobacterium bovis BCG str. Pasteur 1173P2 4695643 YP_977646.1 CDS BCG_1554c NC_008769.1 1706281 1707039 R hypothetical protein complement(1706281..1707039) Mycobacterium bovis BCG str. Pasteur 1173P2 4697509 YP_977647.1 CDS mutA NC_008769.1 1707230 1709077 D methylmalonyl-CoA mutase small subunit mutA 1707230..1709077 Mycobacterium bovis BCG str. Pasteur 1173P2 4695468 YP_977648.1 CDS mutB NC_008769.1 1709078 1711330 D MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 1709078..1711330 Mycobacterium bovis BCG str. Pasteur 1173P2 4697971 YP_977649.1 CDS BCG_1557 NC_008769.1 1711344 1711646 D Differs from Rv1494 and Mb1531 by 1aa, L12S; hypothetical protein 1711344..1711646 Mycobacterium bovis BCG str. Pasteur 1173P2 4697972 YP_977650.1 CDS BCG_1558 NC_008769.1 1711643 1711960 D hypothetical protein 1711643..1711960 Mycobacterium bovis BCG str. Pasteur 1173P2 4697916 YP_977651.1 CDS BCG_1559 NC_008769.1 1711957 1712961 D functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 1711957..1712961 Mycobacterium bovis BCG str. Pasteur 1173P2 4697471 YP_977652.1 CDS lipL NC_008769.1 1713014 1714303 D esterase lipL 1713014..1714303 Mycobacterium bovis BCG str. Pasteur 1173P2 4697545 YP_977653.1 CDS BCG_1561c NC_008769.1 1714376 1714993 R Differs from Rv1498c by 1aa, H191R; methyltransferase complement(1714376..1714993) Mycobacterium bovis BCG str. Pasteur 1173P2 4698633 YP_977654.1 CDS BCG_1562c NC_008769.1 1715207 1715398 R In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a single base transition (a-g) at the 5' start leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (63 aa versus 70 aa); hypothetical protein complement(1715207..1715398) Mycobacterium bovis BCG str. Pasteur 1173P2 4697922 YP_977655.1 CDS BCG_1563 NC_008769.1 1715480 1715878 D hypothetical protein 1715480..1715878 Mycobacterium bovis BCG str. Pasteur 1173P2 4696996 YP_977656.1 CDS BCG_1564 NC_008769.1 1715923 1716951 D Differs from Rv1500 and Mb1538 by 1aa, E45D; glycosyltransferase 1715923..1716951 Mycobacterium bovis BCG str. Pasteur 1173P2 4697892 YP_977657.1 CDS BCG_1565 NC_008769.1 1716963 1717784 D hypothetical protein 1716963..1717784 Mycobacterium bovis BCG str. Pasteur 1173P2 4696802 YP_977658.1 CDS BCG_1566 NC_008769.1 1717997 1718896 D In Mycobacterium bovis BCG Pasteur and Mycobacterium tuberculosis strain H37Rv, Rv1502 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Rv1502 into 2 parts, Mb1540 and Mb1541. Differs from Rv1502 by 1aa, C213Y; hypothetical protein 1717997..1718896 Mycobacterium bovis BCG str. Pasteur 1173P2 4697929 YP_977659.1 CDS BCG_1567c NC_008769.1 1719069 1720217 R catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase complement(1719069..1720217) Mycobacterium bovis BCG str. Pasteur 1173P2 4696803 YP_977660.1 CDS BCG_1568c NC_008769.1 1720354 1721019 R hypothetical protein complement(1720354..1721019) Mycobacterium bovis BCG str. Pasteur 1173P2 4696811 YP_977661.1 CDS BCG_1569 NC_008769.1 1721212 1721976 D Differs from Rv1517 by 1aa, F188L; hypothetical protein 1721212..1721976 Mycobacterium bovis BCG str. Pasteur 1173P2 4697810 YP_977662.1 CDS BCG_1570 NC_008769.1 1721985 1722944 D Differs from Rv1518 by 2aa, R266S, L317M; hypothetical protein 1721985..1722944 Mycobacterium bovis BCG str. Pasteur 1173P2 4697936 YP_977663.1 CDS BCG_1571 NC_008769.1 1723074 1723343 D hypothetical protein 1723074..1723343 Mycobacterium bovis BCG str. Pasteur 1173P2 4697425 YP_977664.1 CDS BCG_1572 NC_008769.1 1723369 1724409 D sugar transferase 1723369..1724409 Mycobacterium bovis BCG str. Pasteur 1173P2 4697446 YP_977665.1 CDS fadD25 NC_008769.1 1724643 1726394 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1724643..1726394 Mycobacterium bovis BCG str. Pasteur 1173P2 4696590 YP_977666.1 CDS mmpL12 NC_008769.1 1726630 1729953 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transversion (c-a) creating a stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1107 aa versus 1146 aa). Differs from Rv1522c (1146 aa) by 1aa, P381S, and from Mb1549c, (1107 aa) by 2aa, T204A, S947N; transmembrane transport protein mmpL12 complement(1726630..1729953) Mycobacterium bovis BCG str. Pasteur 1173P2 4697740 YP_977667.1 CDS BCG_1575 NC_008769.1 1729994 1731037 D methyltransferase 1729994..1731037 Mycobacterium bovis BCG str. Pasteur 1173P2 4697542 YP_977668.1 CDS BCG_1576 NC_008769.1 1731067 1732311 D glycosyltransferase 1731067..1732311 Mycobacterium bovis BCG str. Pasteur 1173P2 4695485 YP_977669.1 CDS wbbL2 NC_008769.1 1732358 1733143 D rhamnosyl transferase wbbL2 1732358..1733143 Mycobacterium bovis BCG str. Pasteur 1173P2 4695386 YP_977670.1 CDS BCG_1578c NC_008769.1 1733121 1734401 R glycosyltransferase complement(1733121..1734401) Mycobacterium bovis BCG str. Pasteur 1173P2 4695495 YP_977671.1 CDS pks5 NC_008769.1 1734424 1740750 R Differs from Rv1527c by 2aa, T532P, L1439F; polyketide synthase pks5 complement(1734424..1740750) Mycobacterium bovis BCG str. Pasteur 1173P2 4697564 YP_977672.1 CDS papA4 NC_008769.1 1741294 1741791 R polyketide synthase associated protein papA4 complement(1741294..1741791) Mycobacterium bovis BCG str. Pasteur 1173P2 4696576 YP_977673.1 CDS fadD24 NC_008769.1 1741843 1743597 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1741843..1743597 Mycobacterium bovis BCG str. Pasteur 1173P2 4698057 YP_977674.1 CDS adh NC_008769.1 1743714 1744817 D Differs from Rv1530 and Mb1557 by 1aa, L330P; alcohol dehydrogenase adh 1743714..1744817 Mycobacterium bovis BCG str. Pasteur 1173P2 4697574 YP_977675.1 CDS BCG_1583 NC_008769.1 1744814 1745380 D hypothetical protein 1744814..1745380 Mycobacterium bovis BCG str. Pasteur 1173P2 4696478 YP_977676.1 CDS BCG_1584c NC_008769.1 1745457 1745891 R hypothetical protein complement(1745457..1745891) Mycobacterium bovis BCG str. Pasteur 1173P2 4699168 YP_977677.1 CDS BCG_1585 NC_008769.1 1745951 1747078 D hypothetical protein 1745951..1747078 Mycobacterium bovis BCG str. Pasteur 1173P2 4697591 YP_977678.1 CDS BCG_1586 NC_008769.1 1747075 1747752 D transcriptional regulator 1747075..1747752 Mycobacterium bovis BCG str. Pasteur 1173P2 4695725 YP_977679.1 CDS BCG_1587 NC_008769.1 1748317 1748553 D hypothetical protein 1748317..1748553 Mycobacterium bovis BCG str. Pasteur 1173P2 4696085 YP_977680.1 CDS ileS NC_008769.1 1748860 1751985 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase 1748860..1751985 Mycobacterium bovis BCG str. Pasteur 1173P2 4697640 YP_977681.1 CDS dinX NC_008769.1 1752197 1753588 D involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 1752197..1753588 Mycobacterium bovis BCG str. Pasteur 1173P2 4696224 YP_977682.1 CDS ansA NC_008769.1 1753553 1754533 R L-aparaginase ansA complement(1753553..1754533) Mycobacterium bovis BCG str. Pasteur 1173P2 4696610 YP_977683.1 CDS lspA NC_008769.1 1754585 1755193 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1754585..1755193 Mycobacterium bovis BCG str. Pasteur 1173P2 4695657 YP_977684.1 CDS BCG_1592 NC_008769.1 1755186 1756112 D hypothetical protein 1755186..1756112 Mycobacterium bovis BCG str. Pasteur 1173P2 4697259 YP_977685.1 CDS lprI NC_008769.1 1756119 1756712 R lipoprotein lprI complement(1756119..1756712) Mycobacterium bovis BCG str. Pasteur 1173P2 4696772 YP_977686.1 CDS glbN NC_008769.1 1756767 1757177 R hemoglobin glbN complement(1756767..1757177) Mycobacterium bovis BCG str. Pasteur 1173P2 4698143 YP_977687.1 CDS BCG_1595 NC_008769.1 1757405 1758430 D fatty acyl-CoA reductase 1757405..1758430 Mycobacterium bovis BCG str. Pasteur 1173P2 4697396 YP_977688.1 CDS BCG_1596 NC_008769.1 1758435 1758533 D BCG_1596; In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, Rv1544 and Mb1571 exist as a single gene. In Mycobacterium bovis BCG Pasteur, two genes exist as a result of a 10 bp deletion that has occurred at a position equivalent to H37Rv position 1746147-1746156I; hypothetical protein 1758435..1758533 Mycobacterium bovis BCG str. Pasteur 1173P2 4696690 YP_977689.1 CDS BCG_1597 NC_008769.1 1758533 1759228 D In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, Rv1544 and Mb1571 exist as a single gene. In Mycobacterium bovis BCG Pasteur, two genes exist as a result of a 10 bp deletion that has occurred at a position equivalent to H37Rv position 1746147-1746156I; ketoacyl reductase 1758533..1759228 Mycobacterium bovis BCG str. Pasteur 1173P2 4696244 YP_977690.1 CDS BCG_1598 NC_008769.1 1759250 1759477 D hypothetical protein 1759250..1759477 Mycobacterium bovis BCG str. Pasteur 1173P2 4697671 YP_977691.1 CDS BCG_1599 NC_008769.1 1759526 1759957 D hypothetical protein 1759526..1759957 Mycobacterium bovis BCG str. Pasteur 1173P2 4697669 YP_977692.1 CDS dnaE NC_008769.1 1760025 1763579 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 1760025..1763579 Mycobacterium bovis BCG str. Pasteur 1173P2 4695706 YP_977693.1 CDS PPE21 NC_008769.1 1763628 1765664 R Differs from Rv1548c by 1aa, G258D, and from Mb1575c by 1aa, V68A; PPE family protein complement(1763628..1765664) Mycobacterium bovis BCG str. Pasteur 1173P2 4696096 YP_977694.1 CDS fadD11 NC_008769.1 1765821 1767764 D In Mycobacterium tuberculosis strain H37Rv, Rv1549 and Rv1550 exist as 2 genes. In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, two single base insertions (*-c and *-c) lead to a single product. Differs from Rv1550 by 1aa, S362L; fatty-acid-CoA ligase FadD11 1765821..1767764 Mycobacterium bovis BCG str. Pasteur 1173P2 4698627 YP_977695.1 CDS plsB1 NC_008769.1 1767778 1769643 D PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 1767778..1769643 Mycobacterium bovis BCG str. Pasteur 1173P2 4695422 YP_977696.1 CDS frdA NC_008769.1 1770013 1771764 D part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 1770013..1771764 Mycobacterium bovis BCG str. Pasteur 1173P2 4695943 YP_977697.1 CDS frdBC NC_008769.1 1771767 1772897 D In Mycobacterium tuberculosis strain H37Rv, Rv1553 and Rv1554 exist as 2 genes. In Mycobacterium bovis, a 4 bp insertion (*-gggg) leads to a single product and in Mycobacterium bovis BCG Pasteur a 10 bp insertion at position equivalent to H37Rv 1760171-1760172 leads to insertion of two additional Gly codons; fumarate reductase frdC 1771767..1772897 Mycobacterium bovis BCG str. Pasteur 1173P2 4697657 YP_977698.1 CDS frdD NC_008769.1 1772894 1773271 D in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 1772894..1773271 Mycobacterium bovis BCG str. Pasteur 1173P2 4697658 YP_977699.1 CDS BCG_1607 NC_008769.1 1773339 1773947 D regulatory protein 1773339..1773947 Mycobacterium bovis BCG str. Pasteur 1173P2 4697659 YP_977700.1 CDS mmpS6 NC_008769.1 1774086 1774532 D In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a 2153 bp insertion leads to a new protein with no equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to the TbD1 region; membrane protein mmpS6 1774086..1774532 Mycobacterium bovis BCG str. Pasteur 1173P2 4697034 YP_977701.1 CDS mmpL6 NC_008769.1 1774529 1777432 D In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 2153 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Belongs to the TbD1 region; transmembrane transport protein mmpL6 1774529..1777432 Mycobacterium bovis BCG str. Pasteur 1173P2 4697598 YP_977702.1 CDS BCG_1610 NC_008769.1 1777442 1777888 D hypothetical protein 1777442..1777888 Mycobacterium bovis BCG str. Pasteur 1173P2 4696172 YP_977703.1 CDS ilvA NC_008769.1 1777923 1779212 D catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 1777923..1779212 Mycobacterium bovis BCG str. Pasteur 1173P2 4698478 YP_977704.1 CDS BCG_1612 NC_008769.1 1779250 1779468 D hypothetical protein 1779250..1779468 Mycobacterium bovis BCG str. Pasteur 1173P2 4696225 YP_977705.1 CDS BCG_1613 NC_008769.1 1779474 1779878 D hypothetical protein 1779474..1779878 Mycobacterium bovis BCG str. Pasteur 1173P2 4696560 YP_977706.1 CDS treZb NC_008769.1 1779895 1780455 R In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, treZa and treZb exist as a single gene, treZ. In Mycobacterium bovis BCG Pasteur, a single base deletion at position equivalent to H37Rv 1766233-1766233 leads to frameshift and two genes, treZa and treZb; maltooligosyltrehalose trehalohydrolase TreZ complement(1779895..1780455) Mycobacterium bovis BCG str. Pasteur 1173P2 4695559 YP_977707.1 CDS treZa NC_008769.1 1780452 1781636 R In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, treZa and treZb exist as a single gene, treZ. In Mycobacterium bovis BCG Pasteur, a single base deletion at position equivalent to H37Rv 1766233-1766233 leads to frameshift and two genes, treZa and treZb; maltooligosyltrehalose trehalohydrolase TreZ complement(1780452..1781636) Mycobacterium bovis BCG str. Pasteur 1173P2 4697328 YP_977708.1 CDS treY NC_008769.1 1781629 1783926 R In Mycobacterium bovis BCG Pasteur, and in Mycobacterium tuberculosis strain H37Rv, treY exists as a single gene. In Mycobacterium bovis, a large deletion of 806 bp, RD17, splits Rv1563c into two parts, treYa and treYb; maltooligosyltrehalose synthase TreY complement(1781629..1783926) Mycobacterium bovis BCG str. Pasteur 1173P2 4697327 YP_977709.1 CDS treX NC_008769.1 1783930 1786095 R maltooligosyltrehalose synthase TreX complement(1783930..1786095) Mycobacterium bovis BCG str. Pasteur 1173P2 4696823 YP_977710.1 CDS BCG_1618c NC_008769.1 1786134 1788323 R hypothetical protein complement(1786134..1788323) Mycobacterium bovis BCG str. Pasteur 1173P2 4696822 YP_977711.1 CDS BCG_1619c NC_008769.1 1788422 1789114 R inv protein complement(1788422..1789114) Mycobacterium bovis BCG str. Pasteur 1173P2 4696813 YP_977712.1 CDS BCG_1620c NC_008769.1 1789354 1789638 R hypothetical protein complement(1789354..1789638) Mycobacterium bovis BCG str. Pasteur 1173P2 4697678 YP_977713.1 CDS bioA NC_008769.1 1789886 1791199 D catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1789886..1791199 Mycobacterium bovis BCG str. Pasteur 1173P2 4696087 YP_977714.1 CDS bioF1 NC_008769.1 1791196 1792356 D catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 1791196..1792356 Mycobacterium bovis BCG str. Pasteur 1173P2 4695858 YP_977715.1 CDS bioD NC_008769.1 1792353 1793033 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1792353..1793033 Mycobacterium bovis BCG str. Pasteur 1173P2 4696194 YP_977716.1 CDS BCG_1624 NC_008769.1 1793033 1793542 D hypothetical protein 1793033..1793542 Mycobacterium bovis BCG str. Pasteur 1173P2 4699259 YP_977717.1 CDS BCG_1625c NC_008769.1 1793688 1794644 R In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis, Rv1587c possibly exists as a pseudogene that has been disrupted when the phage entered. In Mycobacterium bovis BCG Pasteur, the prophage is absent and the C-terminal part of protein differs accordingly; hypothetical protein complement(1793688..1794644) Mycobacterium bovis BCG str. Pasteur 1173P2 4698167 YP_977718.1 CDS BCG_1626c NC_008769.1 1794415 1795083 R Differs from Rv1588c by 3aa, T63A, L91R, I131V; hypothetical protein complement(1794415..1795083) Mycobacterium bovis BCG str. Pasteur 1173P2 4696700 YP_977719.1 CDS bioB NC_008769.1 1795531 1796580 D catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase 1795531..1796580 Mycobacterium bovis BCG str. Pasteur 1173P2 4696627 YP_977720.1 CDS BCG_1628 NC_008769.1 1796581 1796820 D hypothetical protein 1796581..1796820 Mycobacterium bovis BCG str. Pasteur 1173P2 4697186 YP_977721.1 CDS BCG_1629 NC_008769.1 1796817 1797482 D hypothetical protein 1796817..1797482 Mycobacterium bovis BCG str. Pasteur 1173P2 4697603 YP_977722.1 CDS BCG_1630c NC_008769.1 1797647 1798987 R Differs from Rv1592c by 1aa, V322I; hypothetical protein complement(1797647..1798987) Mycobacterium bovis BCG str. Pasteur 1173P2 4697676 YP_977723.1 CDS BCG_1631c NC_008769.1 1799244 1799954 R hypothetical protein complement(1799244..1799954) Mycobacterium bovis BCG str. Pasteur 1173P2 4696542 YP_977724.1 CDS nadA NC_008769.1 1800003 1801052 D 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 1800003..1801052 Mycobacterium bovis BCG str. Pasteur 1173P2 4695469 YP_977725.1 CDS nadB NC_008769.1 1801052 1802635 D catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 1801052..1802635 Mycobacterium bovis BCG str. Pasteur 1173P2 4695713 YP_977726.1 CDS nadC NC_008769.1 1802635 1803492 D catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 1802635..1803492 Mycobacterium bovis BCG str. Pasteur 1173P2 4695714 YP_977727.1 CDS BCG_1635 NC_008769.1 1803541 1804299 D Differs from Rv1597 by 2aa, D21G, M93L, and from Mb1623 by 1aa, M93L; hypothetical protein 1803541..1804299 Mycobacterium bovis BCG str. Pasteur 1173P2 4695715 YP_977728.1 CDS BCG_1636c NC_008769.1 1804320 1804730 R hypothetical protein complement(1804320..1804730) Mycobacterium bovis BCG str. Pasteur 1173P2 4695671 YP_977729.1 CDS hisD NC_008769.1 1804830 1806146 D catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1804830..1806146 Mycobacterium bovis BCG str. Pasteur 1173P2 4696261 YP_977730.1 CDS hisC1 NC_008769.1 1806143 1807285 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1806143..1807285 Mycobacterium bovis BCG str. Pasteur 1173P2 4696168 YP_977731.1 CDS hisB NC_008769.1 1807282 1807914 D catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 1807282..1807914 Mycobacterium bovis BCG str. Pasteur 1173P2 4696166 YP_977732.1 CDS hisH NC_008769.1 1807911 1808531 D with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1807911..1808531 Mycobacterium bovis BCG str. Pasteur 1173P2 4696165 YP_977733.1 CDS hisA NC_008769.1 1808541 1809278 D catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; phosphoribosyl isomerase A 1808541..1809278 Mycobacterium bovis BCG str. Pasteur 1173P2 4696068 YP_977734.1 CDS impA NC_008769.1 1809286 1810098 D Differs from Rv1604 by 3aa, H93Y, Q124P, L251P; inositol-monophosphatase impA 1809286..1810098 Mycobacterium bovis BCG str. Pasteur 1173P2 4696164 YP_977735.1 CDS hisF NC_008769.1 1810100 1810903 D catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 1810100..1810903 Mycobacterium bovis BCG str. Pasteur 1173P2 4698976 YP_977736.1 CDS hisI NC_008769.1 1810900 1811247 D PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase 1810900..1811247 Mycobacterium bovis BCG str. Pasteur 1173P2 4696066 YP_977737.1 CDS chaA NC_008769.1 1811428 1812510 D ionic transporter integral membrane protein chaA 1811428..1812510 Mycobacterium bovis BCG str. Pasteur 1173P2 4696069 YP_977738.1 CDS bcpB NC_008769.1 1812545 1813009 R peroxidoxin bcpB complement(1812545..1813009) Mycobacterium bovis BCG str. Pasteur 1173P2 4697511 YP_977739.1 CDS trpE NC_008769.1 1813150 1814700 D with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1813150..1814700 Mycobacterium bovis BCG str. Pasteur 1173P2 4696505 YP_977740.1 CDS BCG_1648 NC_008769.1 1814690 1815397 D hypothetical protein 1814690..1815397 Mycobacterium bovis BCG str. Pasteur 1173P2 4695827 YP_977741.1 CDS trpC NC_008769.1 1815487 1816305 D involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase 1815487..1816305 Mycobacterium bovis BCG str. Pasteur 1173P2 4697571 YP_977742.1 CDS trpB NC_008769.1 1816374 1817606 D catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1816374..1817606 Mycobacterium bovis BCG str. Pasteur 1173P2 4696871 YP_977743.1 CDS trpA NC_008769.1 1817606 1818418 D catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1817606..1818418 Mycobacterium bovis BCG str. Pasteur 1173P2 4696870 YP_977744.1 CDS lgt NC_008769.1 1818418 1819824 D transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1818418..1819824 Mycobacterium bovis BCG str. Pasteur 1173P2 4696869 YP_977745.1 CDS BCG_1653 NC_008769.1 1820500 1820940 D hypothetical protein 1820500..1820940 Mycobacterium bovis BCG str. Pasteur 1173P2 4697269 YP_977746.1 CDS BCG_1654 NC_008769.1 1820930 1821328 D hypothetical protein 1820930..1821328 Mycobacterium bovis BCG str. Pasteur 1173P2 4697061 YP_977747.1 CDS pykA NC_008769.1 1821436 1822854 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1821436..1822854 Mycobacterium bovis BCG str. Pasteur 1173P2 4695734 YP_977748.1 CDS tesB1 NC_008769.1 1822862 1823764 D Differs from Rv1618 by 1aa, L121H; acyl-CoA thioesterase II tesB1 1822862..1823764 Mycobacterium bovis BCG str. Pasteur 1173P2 4696882 YP_977749.1 CDS BCG_1657 NC_008769.1 1823822 1825276 D hypothetical protein 1823822..1825276 Mycobacterium bovis BCG str. Pasteur 1173P2 4696850 YP_977750.1 CDS cydC NC_008769.1 1825210 1826940 R cytochrome assembly ABC transporter ATP-binding protein CydC complement(1825210..1826940) Mycobacterium bovis BCG str. Pasteur 1173P2 4696197 YP_977751.1 CDS cydD NC_008769.1 1826937 1828520 R cytochrome assembly ABC transporter ATP-binding protein CydD complement(1826937..1828520) Mycobacterium bovis BCG str. Pasteur 1173P2 4696657 YP_977752.1 CDS cydB NC_008769.1 1828607 1829647 R integral membrane cytochrome D ubiquinol oxidase (subunit II) cydB complement(1828607..1829647) Mycobacterium bovis BCG str. Pasteur 1173P2 4698414 YP_977753.1 CDS cydA NC_008769.1 1829677 1831134 R integral membrane cytochrome D ubiquinol oxidase (subunit I) cydA complement(1829677..1831134) Mycobacterium bovis BCG str. Pasteur 1173P2 4697166 YP_977754.1 CDS BCG_1662c NC_008769.1 1831245 1831832 R Differs from Rv1624c by 1aa, A178T; hypothetical protein complement(1831245..1831832) Mycobacterium bovis BCG str. Pasteur 1173P2 4696467 YP_977755.1 CDS cya NC_008769.1 1831861 1833117 R membrane-anchored adenylyl cyclase cya complement(1831861..1833117) Mycobacterium bovis BCG str. Pasteur 1173P2 4696392 YP_977756.1 CDS BCG_1664 NC_008769.1 1833427 1834044 D two-component system transcriptional regulator 1833427..1834044 Mycobacterium bovis BCG str. Pasteur 1173P2 4696750 YP_977757.1 CDS BCG_1665c NC_008769.1 1834112 1835320 R lipid-transfer protein complement(1834112..1835320) Mycobacterium bovis BCG str. Pasteur 1173P2 4695610 YP_977758.1 CDS BCG_1666c NC_008769.1 1835317 1835808 R Differs from Rv1628c and Mb1654c by 1aa, V93A; hypothetical protein complement(1835317..1835808) Mycobacterium bovis BCG str. Pasteur 1173P2 4697102 YP_977759.1 CDS polA NC_008769.1 1835912 1838626 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 1835912..1838626 Mycobacterium bovis BCG str. Pasteur 1173P2 4697474 YP_977760.1 CDS rpsA NC_008769.1 1838789 1840234 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1838789..1840234 Mycobacterium bovis BCG str. Pasteur 1173P2 4696278 YP_977761.1 CDS coaE NC_008769.1 1840260 1841483 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain; dephospho-CoA kinase/protein folding accessory domain-containing protein 1840260..1841483 Mycobacterium bovis BCG str. Pasteur 1173P2 4696378 YP_977762.1 CDS BCG_1670c NC_008769.1 1841634 1842077 R hypothetical protein complement(1841634..1842077) Mycobacterium bovis BCG str. Pasteur 1173P2 4698571 YP_977763.1 CDS uvrB NC_008769.1 1842322 1844418 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1842322..1844418 Mycobacterium bovis BCG str. Pasteur 1173P2 4697613 YP_977764.1 CDS BCG_1672 NC_008769.1 1844415 1845830 D Differs from Rv1634 by 2aa, Q13E, R198G, and from Mb1660 by 1aa, Q13E; drug efflux membrane protein 1844415..1845830 Mycobacterium bovis BCG str. Pasteur 1173P2 4697750 YP_977765.1 CDS BCG_1673c NC_008769.1 1845819 1847489 R hypothetical protein complement(1845819..1847489) Mycobacterium bovis BCG str. Pasteur 1173P2 4698447 YP_977766.1 CDS TB15.3 NC_008769.1 1847698 1848138 D hypothetical protein 1847698..1848138 Mycobacterium bovis BCG str. Pasteur 1173P2 4696698 YP_977767.1 CDS BCG_1675c NC_008769.1 1848145 1848939 R hypothetical protein complement(1848145..1848939) Mycobacterium bovis BCG str. Pasteur 1173P2 4697559 YP_977768.1 CDS uvrA NC_008769.1 1848988 1851906 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 1848988..1851906 Mycobacterium bovis BCG str. Pasteur 1173P2 4697612 YP_977769.1 CDS BCG_1677c NC_008769.1 1851963 1852220 R hypothetical protein complement(1851963..1852220) Mycobacterium bovis BCG str. Pasteur 1173P2 4697749 YP_977770.1 CDS BCG_1678c NC_008769.1 1852236 1853705 R hypothetical protein complement(1852236..1853705) Mycobacterium bovis BCG str. Pasteur 1173P2 4697124 YP_977771.1 CDS lysS NC_008769.1 1853764 1857282 R catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase complement(1853764..1857282) Mycobacterium bovis BCG str. Pasteur 1173P2 4695723 YP_977772.1 CDS infC NC_008769.1 1857519 1858124 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1857519..1858124 Mycobacterium bovis BCG str. Pasteur 1173P2 4697179 YP_977773.1 CDS rpmI NC_008769.1 1858174 1858368 D 50S ribosomal protein L35 1858174..1858368 Mycobacterium bovis BCG str. Pasteur 1173P2 4697075 YP_977774.1 CDS rplT NC_008769.1 1858430 1858819 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1858430..1858819 Mycobacterium bovis BCG str. Pasteur 1173P2 4695800 YP_977775.1 CDS tsnR NC_008769.1 1858852 1859634 D Differs from Rv1644 by 1aa, P232L; 23S rRNA methyltransferase tsnR 1858852..1859634 Mycobacterium bovis BCG str. Pasteur 1173P2 4695880 YP_977776.1 CDS BCG_1684c NC_008769.1 1859645 1860700 R hypothetical protein complement(1859645..1860700) Mycobacterium bovis BCG str. Pasteur 1173P2 4697090 YP_977777.1 CDS PE17 NC_008769.1 1861010 1861942 D PE family protein 1861010..1861942 Mycobacterium bovis BCG str. Pasteur 1173P2 4697534 YP_977778.1 CDS BCG_1686 NC_008769.1 1862020 1862970 D Differs from Rv1647 by 1aa, P2A; hypothetical protein 1862020..1862970 Mycobacterium bovis BCG str. Pasteur 1173P2 4699007 YP_977779.1 CDS BCG_1687 NC_008769.1 1862977 1863783 D hypothetical protein 1862977..1863783 Mycobacterium bovis BCG str. Pasteur 1173P2 4697092 YP_977780.1 CDS pheS NC_008769.1 1863979 1865004 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1863979..1865004 Mycobacterium bovis BCG str. Pasteur 1173P2 4695647 YP_977781.1 CDS pheT NC_008769.1 1865004 1867499 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1865004..1867499 Mycobacterium bovis BCG str. Pasteur 1173P2 4697583 YP_977782.1 CDS PE_PGRS30 NC_008769.1 1867593 1870649 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, an in-frame insertion of 21 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1018 aa versus 1011 aa). Differs from Rv1651c by insertion of 7aa at position 152 and by 1aa, V179A; PE-PGRS family protein complement(1867593..1870649) Mycobacterium bovis BCG str. Pasteur 1173P2 4697584 YP_977783.1 CDS argC NC_008769.1 1870843 1871901 D catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 1870843..1871901 Mycobacterium bovis BCG str. Pasteur 1173P2 4696582 YP_977784.1 CDS argJ NC_008769.1 1871898 1873112 D bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase 1871898..1873112 Mycobacterium bovis BCG str. Pasteur 1173P2 4699129 YP_977785.1 CDS argB NC_008769.1 1873109 1873993 D catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 1873109..1873993 Mycobacterium bovis BCG str. Pasteur 1173P2 4696230 YP_977786.1 CDS argD NC_008769.1 1873990 1875192 D catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase 1873990..1875192 Mycobacterium bovis BCG str. Pasteur 1173P2 4697018 YP_977787.1 CDS argF NC_008769.1 1875189 1876112 D catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 1875189..1876112 Mycobacterium bovis BCG str. Pasteur 1173P2 4696357 YP_977788.1 CDS argR NC_008769.1 1876109 1876621 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 1876109..1876621 Mycobacterium bovis BCG str. Pasteur 1173P2 4697195 YP_977789.1 CDS argG NC_008769.1 1876630 1877826 D catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 1876630..1877826 Mycobacterium bovis BCG str. Pasteur 1173P2 4696670 YP_977790.1 CDS argH NC_008769.1 1877906 1879318 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 1877906..1879318 Mycobacterium bovis BCG str. Pasteur 1173P2 4696651 YP_977791.1 CDS pks10 NC_008769.1 1879427 1880488 D chalcone synthase pks10 1879427..1880488 Mycobacterium bovis BCG str. Pasteur 1173P2 4695598 YP_977792.1 CDS pks7 NC_008769.1 1880571 1886951 D Differs from Rv1661 by 2aa, W670R, P1176S; polyketide synthase pks7 1880571..1886951 Mycobacterium bovis BCG str. Pasteur 1173P2 4696190 YP_977793.1 CDS pks8 NC_008769.1 1886971 1891776 D Differs from Rv1662 by 6aa, Y78D, deletion of V692, V807A, G1260R, T1356A, C1468Y, and from Mb1690 by 1aa, deletion of V692; polyketide synthase 1886971..1891776 Mycobacterium bovis BCG str. Pasteur 1173P2 4696579 YP_977794.1 CDS pks17 NC_008769.1 1891776 1893284 D polyketide synthase 1891776..1893284 Mycobacterium bovis BCG str. Pasteur 1173P2 4696580 YP_977795.1 CDS pks9 NC_008769.1 1893290 1896343 D Differs from Rv1664 by 2aa, T36A, P350A; polyketide synthase pks9 1893290..1896343 Mycobacterium bovis BCG str. Pasteur 1173P2 4698459 YP_977796.1 CDS pks11 NC_008769.1 1896490 1897551 D chalcone synthase pks11 1896490..1897551 Mycobacterium bovis BCG str. Pasteur 1173P2 4695941 YP_977797.1 CDS cyp139 NC_008769.1 1897534 1898826 R cytochrome P450 139 CYP139 complement(1897534..1898826) Mycobacterium bovis BCG str. Pasteur 1173P2 4696191 YP_977798.1 CDS BCG_1706c NC_008769.1 1898841 1900616 R In Mycobacterium tuberculosis strain H37Rv, Rv1668c and Rv1667c exist as 2 genes with a small overlap between them. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 10 bp insertion (*-tcttgccgcg) leads to a single product; macrolide ABC transporter ATP-binding protein complement(1898841..1900616) Mycobacterium bovis BCG str. Pasteur 1173P2 4696228 YP_977799.1 CDS BCG_1707 NC_008769.1 1900999 1901361 D hypothetical protein 1900999..1901361 Mycobacterium bovis BCG str. Pasteur 1173P2 4696348 YP_977800.1 CDS BCG_1708 NC_008769.1 1901394 1901741 D hypothetical protein 1901394..1901741 Mycobacterium bovis BCG str. Pasteur 1173P2 4697136 YP_977801.1 CDS BCG_1709 NC_008769.1 1901749 1902141 D hypothetical protein 1901749..1902141 Mycobacterium bovis BCG str. Pasteur 1173P2 4697162 YP_977802.1 CDS BCG_1710c NC_008769.1 1902150 1903481 R integral membrane transport protein complement(1902150..1903481) Mycobacterium bovis BCG str. Pasteur 1173P2 4695573 YP_977803.1 CDS BCG_1711c NC_008769.1 1903574 1904506 R hypothetical protein complement(1903574..1904506) Mycobacterium bovis BCG str. Pasteur 1173P2 4697833 YP_977804.1 CDS BCG_1712c NC_008769.1 1904534 1905190 R transcriptional regulatory protein complement(1904534..1905190) Mycobacterium bovis BCG str. Pasteur 1173P2 4697546 YP_977805.1 CDS BCG_1713c NC_008769.1 1905515 1906249 R Differs from Rv1675c by 1aa, A59V; transcriptional regulatory protein complement(1905515..1906249) Mycobacterium bovis BCG str. Pasteur 1173P2 4697059 YP_977806.1 CDS BCG_1714 NC_008769.1 1906321 1907025 D hypothetical protein 1906321..1907025 Mycobacterium bovis BCG str. Pasteur 1173P2 4696685 YP_977807.1 CDS dsbF NC_008769.1 1907022 1907570 D lipoprotein dsbF 1907022..1907570 Mycobacterium bovis BCG str. Pasteur 1173P2 4696656 YP_977808.1 CDS BCG_1716 NC_008769.1 1907671 1908573 D hypothetical protein 1907671..1908573 Mycobacterium bovis BCG str. Pasteur 1173P2 4698466 YP_977809.1 CDS fadE16 NC_008769.1 1908573 1909694 D acyl-CoA dehydrogenase fadE16 1908573..1909694 Mycobacterium bovis BCG str. Pasteur 1173P2 4696792 YP_977810.1 CDS BCG_1718 NC_008769.1 1909703 1910527 D Differs from Mb1707 by 1aa, A230G; hypothetical protein 1909703..1910527 Mycobacterium bovis BCG str. Pasteur 1173P2 4697443 YP_977811.1 CDS moeX NC_008769.1 1910524 1911516 D molybdopterin biosynthesis protein moeX 1910524..1911516 Mycobacterium bovis BCG str. Pasteur 1173P2 4697380 YP_977812.1 CDS BCG_1720 NC_008769.1 1911677 1912594 D coiled-coil structural protein 1911677..1912594 Mycobacterium bovis BCG str. Pasteur 1173P2 4697175 YP_977813.1 CDS BCG_1721 NC_008769.1 1912812 1915811 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1912812..1915811 Mycobacterium bovis BCG str. Pasteur 1173P2 4695722 YP_977814.1 CDS BCG_1722 NC_008769.1 1915804 1916028 D hypothetical protein 1915804..1916028 Mycobacterium bovis BCG str. Pasteur 1173P2 4696263 YP_977815.1 CDS BCG_1723c NC_008769.1 1915994 1916617 R hypothetical protein complement(1915994..1916617) Mycobacterium bovis BCG str. Pasteur 1173P2 4696637 YP_977816.1 CDS BCG_1724c NC_008769.1 1916619 1917299 R Differs from Rv1686c by 1aa, F20V; integral membrane protein ABC transporter complement(1916619..1917299) Mycobacterium bovis BCG str. Pasteur 1173P2 4696543 YP_977817.1 CDS BCG_1725c NC_008769.1 1917371 1918138 R ABC transporter ATP-binding protein complement(1917371..1918138) Mycobacterium bovis BCG str. Pasteur 1173P2 4695620 YP_977818.1 CDS BCG_1726 NC_008769.1 1918197 1918808 D responsible for recognizing base lesions in the genome and initiating base excision DNA repair; 3-methyladenine DNA glycosylase 1918197..1918808 Mycobacterium bovis BCG str. Pasteur 1173P2 4695537 YP_977819.1 CDS tyrS NC_008769.1 1918820 1920094 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1918820..1920094 Mycobacterium bovis BCG str. Pasteur 1173P2 4697025 YP_977820.1 CDS lprJ NC_008769.1 1920745 1921128 D In Mycobacterium bovis, a 2 bp insertion (*-ac) at the 5' end, leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG Pasteur(139 aa versus 127 aa); lipoprotein lprJ 1920745..1921128 Mycobacterium bovis BCG str. Pasteur 1173P2 4696864 YP_977821.1 CDS BCG_1729 NC_008769.1 1921167 1921919 D hypothetical protein 1921167..1921919 Mycobacterium bovis BCG str. Pasteur 1173P2 4698144 YP_977822.1 CDS BCG_1730 NC_008769.1 1921916 1922977 D phosphatase 1921916..1922977 Mycobacterium bovis BCG str. Pasteur 1173P2 4696476 YP_977823.1 CDS BCG_1731 NC_008769.1 1922974 1923150 D hypothetical protein 1922974..1923150 Mycobacterium bovis BCG str. Pasteur 1173P2 4696134 YP_977824.1 CDS tlyA NC_008769.1 1923158 1923964 D cytotoxin/hemolysin TlyA 1923158..1923964 Mycobacterium bovis BCG str. Pasteur 1173P2 4695547 YP_977825.1 CDS ppnK NC_008769.1 1923964 1924887 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1923964..1924887 Mycobacterium bovis BCG str. Pasteur 1173P2 4696386 YP_977826.1 CDS recN NC_008769.1 1924901 1926664 D DNA repair protein recN 1924901..1926664 Mycobacterium bovis BCG str. Pasteur 1173P2 4696368 YP_977827.1 CDS BCG_1735 NC_008769.1 1926760 1927941 D hypothetical protein 1926760..1927941 Mycobacterium bovis BCG str. Pasteur 1173P2 4695839 YP_977828.1 CDS BCG_1736 NC_008769.1 1927963 1928907 D hypothetical protein 1927963..1928907 Mycobacterium bovis BCG str. Pasteur 1173P2 4696206 YP_977829.1 CDS pyrG NC_008769.1 1929047 1930807 D CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1929047..1930807 Mycobacterium bovis BCG str. Pasteur 1173P2 4697320 YP_977830.1 CDS BCG_1738 NC_008769.1 1930800 1931423 D Differs from Mb1726 by 2aa, F43L, A202T; hypothetical protein 1930800..1931423 Mycobacterium bovis BCG str. Pasteur 1173P2 4697786 YP_977831.1 CDS xerD NC_008769.1 1931420 1932355 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 1931420..1932355 Mycobacterium bovis BCG str. Pasteur 1173P2 4696629 YP_977832.1 CDS BCG_1740c NC_008769.1 1932429 1933793 R hypothetical protein complement(1932429..1933793) Mycobacterium bovis BCG str. Pasteur 1173P2 4696276 YP_977833.1 CDS BCG_1741c NC_008769.1 1934348 1934938 R Differs from Rv1703c and Mb1729c by 1aa, S48G; catechol-o-methyltransferase complement(1934348..1934938) Mycobacterium bovis BCG str. Pasteur 1173P2 4695640 YP_977834.1 CDS cycA NC_008769.1 1935003 1936673 R Differs from Rv1704c by 2aa, L93R, S122G, and from Mb1730c by 1aa, S122G; D-serine/alanine/glycine transporter protein cycA complement(1935003..1936673) Mycobacterium bovis BCG str. Pasteur 1173P2 4698430 YP_977835.1 CDS PPE22 NC_008769.1 1936714 1937871 R Differs from Rv1705c by 2aa, A2D, V313L, and from Mb1731c by 1aa, A2D; PPE family protein complement(1936714..1937871) Mycobacterium bovis BCG str. Pasteur 1173P2 4695846 YP_977836.1 CDS PPE23 NC_008769.1 1937911 1939095 R PPE family protein complement(1937911..1939095) Mycobacterium bovis BCG str. Pasteur 1173P2 4698628 YP_977837.1 CDS BCG_1745c NC_008769.1 1939699 1939866 R hypothetical protein complement(1939699..1939866) Mycobacterium bovis BCG str. Pasteur 1173P2 4698629 YP_977838.1 CDS BCG_1746 NC_008769.1 1940099 1941559 D Differs from Rv1707 by 1aa, Q438R; hypothetical protein 1940099..1941559 Mycobacterium bovis BCG str. Pasteur 1173P2 4697322 YP_977839.1 CDS BCG_1747 NC_008769.1 1941577 1942533 D Differs from Rv1708 by 1a,a T56A; initiation inhibitor protein 1941577..1942533 Mycobacterium bovis BCG str. Pasteur 1173P2 4697165 YP_977840.1 CDS BCG_1748 NC_008769.1 1942530 1943366 D hypothetical protein 1942530..1943366 Mycobacterium bovis BCG str. Pasteur 1173P2 4697121 YP_977841.1 CDS BCG_1749 NC_008769.1 1943363 1944058 D hypothetical protein 1943363..1944058 Mycobacterium bovis BCG str. Pasteur 1173P2 4696237 YP_977842.1 CDS BCG_1750 NC_008769.1 1944055 1944819 D hypothetical protein 1944055..1944819 Mycobacterium bovis BCG str. Pasteur 1173P2 4695692 YP_977843.1 CDS cmk NC_008769.1 1944816 1945508 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1944816..1945508 Mycobacterium bovis BCG str. Pasteur 1173P2 4697900 YP_977844.1 CDS engA NC_008769.1 1945505 1946896 D synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1945505..1946896 Mycobacterium bovis BCG str. Pasteur 1173P2 4698565 YP_977845.1 CDS BCG_1753 NC_008769.1 1947070 1947882 D oxidoreductase 1947070..1947882 Mycobacterium bovis BCG str. Pasteur 1173P2 4697850 YP_977846.1 CDS fadB3 NC_008769.1 1947876 1948790 D In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur, Rv1715/fadB3 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) splits fadB3 into 2 parts, fadB3a and fadB3b; 3-hydroxybutyryl-CoA dehydrogenase 1947876..1948790 Mycobacterium bovis BCG str. Pasteur 1173P2 4697480 YP_977847.1 CDS BCG_1755 NC_008769.1 1948793 1949623 D Differs from Rv1716 by 2aa, G178S, A276V; hypothetical protein 1948793..1949623 Mycobacterium bovis BCG str. Pasteur 1173P2 4698284 YP_977848.1 CDS BCG_1756 NC_008769.1 1949623 1949973 D hypothetical protein 1949623..1949973 Mycobacterium bovis BCG str. Pasteur 1173P2 4697632 YP_977849.1 CDS BCG_1757 NC_008769.1 1950026 1950649 D In Mycobacterium tuberculosis strain H37Rv, exists as a single gene. In Mycobacterium bovis AF2122/97 and Mycobacterium bovis BCG Pasteur, a single base deletion (c-*) leads to a shorter product with a different COOH terminus; hypothetical protein 1950026..1950649 Mycobacterium bovis BCG str. Pasteur 1173P2 4695916 YP_977850.1 CDS BCG_1758 NC_008769.1 1950857 1951636 D transcriptional regulatory protein 1950857..1951636 Mycobacterium bovis BCG str. Pasteur 1173P2 4697529 YP_977851.1 CDS BCG_1759c NC_008769.1 1952246 1952635 R hypothetical protein complement(1952246..1952635) Mycobacterium bovis BCG str. Pasteur 1173P2 4695948 YP_977852.1 CDS BCG_1760c NC_008769.1 1952632 1952859 R hypothetical protein complement(1952632..1952859) Mycobacterium bovis BCG str. Pasteur 1173P2 4698888 YP_977853.1 CDS BCG_1761 NC_008769.1 1953077 1954561 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; biotin carboxylase-like protein 1953077..1954561 Mycobacterium bovis BCG str. Pasteur 1173P2 4696735 YP_977854.1 CDS BCG_1762 NC_008769.1 1954558 1955805 D hydrolase 1954558..1955805 Mycobacterium bovis BCG str. Pasteur 1173P2 4695642 YP_977855.1 CDS BCG_1763c NC_008769.1 1955848 1956267 R hypothetical protein complement(1955848..1956267) Mycobacterium bovis BCG str. Pasteur 1173P2 4695535 YP_977856.1 CDS BCG_1764c NC_008769.1 1956257 1956967 R hypothetical protein complement(1956257..1956967) Mycobacterium bovis BCG str. Pasteur 1173P2 4698398 YP_977857.1 CDS BCG_1765 NC_008769.1 1957068 1958453 D Differs from Rv1726 by 1aa, Y326H, and from Mb1755 by 1aa, A61P; oxidoreductase 1957068..1958453 Mycobacterium bovis BCG str. Pasteur 1173P2 4697417 YP_977858.1 CDS BCG_1766 NC_008769.1 1958486 1959055 D Differs from Rv1727 and Mb1756 by 1aa, D22E; hypothetical protein 1958486..1959055 Mycobacterium bovis BCG str. Pasteur 1173P2 4695565 YP_977859.1 CDS BCG_1767c NC_008769.1 1959080 1959850 R hypothetical protein complement(1959080..1959850) Mycobacterium bovis BCG str. Pasteur 1173P2 4697042 YP_977860.1 CDS BCG_1768c NC_008769.1 1959847 1960785 R hypothetical protein complement(1959847..1960785) Mycobacterium bovis BCG str. Pasteur 1173P2 4697646 YP_977861.1 CDS BCG_1769c NC_008769.1 1960851 1962404 R penicillin-binding protein complement(1960851..1962404) Mycobacterium bovis BCG str. Pasteur 1173P2 4695526 YP_977862.1 CDS gabD2 NC_008769.1 1962836 1964392 D NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinate-semialdehyde dehydrogenase 1962836..1964392 Mycobacterium bovis BCG str. Pasteur 1173P2 4697644 YP_977863.1 CDS BCG_1771c NC_008769.1 1964402 1964950 R hypothetical protein complement(1964402..1964950) Mycobacterium bovis BCG str. Pasteur 1173P2 4695549 YP_977864.1 CDS BCG_1772c NC_008769.1 1965014 1965646 R Differs from Rv1733c by 1aa, H68Q; hypothetical protein complement(1965014..1965646) Mycobacterium bovis BCG str. Pasteur 1173P2 4697334 YP_977865.1 CDS BCG_1773c NC_008769.1 1965933 1966175 R Differs from Mb1763c by 1aa, T79A; hypothetical protein complement(1965933..1966175) Mycobacterium bovis BCG str. Pasteur 1173P2 4695678 YP_977866.1 CDS BCG_1774c NC_008769.1 1966450 1966947 R hypothetical protein complement(1966450..1966947) Mycobacterium bovis BCG str. Pasteur 1173P2 4696857 YP_977867.1 CDS narX NC_008769.1 1967387 1969345 R Diffesr from Rv1736c by 2aa, H53D, G77D; nitrate reductase NarX complement(1967387..1969345) Mycobacterium bovis BCG str. Pasteur 1173P2 4697527 YP_977868.1 CDS narK2 NC_008769.1 1969342 1970529 R nitrate/nitrite transporter narK2 complement(1969342..1970529) Mycobacterium bovis BCG str. Pasteur 1173P2 4697470 YP_977869.1 CDS BCG_1777 NC_008769.1 1970816 1971100 D hypothetical protein 1970816..1971100 Mycobacterium bovis BCG str. Pasteur 1173P2 4697466 YP_977870.1 CDS BCG_1778c NC_008769.1 1971114 1972796 R Differs from Rv1739c by 1aa, L134R; sulfate-transport transmembrane protein ABC transporter complement(1971114..1972796) Mycobacterium bovis BCG str. Pasteur 1173P2 4696672 YP_977871.1 CDS BCG_1779 NC_008769.1 1972864 1973076 D hypothetical protein 1972864..1973076 Mycobacterium bovis BCG str. Pasteur 1173P2 4697742 YP_977872.1 CDS BCG_1780 NC_008769.1 1973076 1973324 D Differs from Rv1741 by 1aa, T67K; hypothetical protein 1973076..1973324 Mycobacterium bovis BCG str. Pasteur 1173P2 4697508 YP_977873.1 CDS BCG_1781 NC_008769.1 1973405 1974070 D In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-c) leads to shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; hypothetical protein 1973405..1974070 Mycobacterium bovis BCG str. Pasteur 1173P2 4696554 YP_977874.1 CDS pknE NC_008769.1 1974164 1975864 D Differs from Mb1772 by 1aa, V56D; transmembrane serine/threonine-protein kinase E pknE 1974164..1975864 Mycobacterium bovis BCG str. Pasteur 1173P2 4695833 YP_977875.1 CDS BCG_1783c NC_008769.1 1976149 1976550 R Differs from Rv1744c by 1aa, Q121R; hypothetical protein complement(1976149..1976550) Mycobacterium bovis BCG str. Pasteur 1173P2 4696552 YP_977876.1 CDS idi NC_008769.1 1976621 1977151 R catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase complement(1976621..1977151) Mycobacterium bovis BCG str. Pasteur 1173P2 4697130 YP_977877.1 CDS pknF NC_008769.1 1977298 1978728 D Differs from Rv1746 by 1aa, T325A; anchored-membrane serine/threonine-protein kinase pknF 1977298..1978728 Mycobacterium bovis BCG str. Pasteur 1173P2 4699217 YP_977878.1 CDS BCG_1786 NC_008769.1 1978790 1981387 D transmembrane ABC transporter ATP-binding protein 1978790..1981387 Mycobacterium bovis BCG str. Pasteur 1173P2 4696553 YP_977879.1 CDS BCG_1787 NC_008769.1 1981760 1982491 D hypothetical protein 1981760..1982491 Mycobacterium bovis BCG str. Pasteur 1173P2 4695562 YP_977880.1 CDS BCG_1788c NC_008769.1 1982488 1983045 R integral membrane protein complement(1982488..1983045) Mycobacterium bovis BCG str. Pasteur 1173P2 4696719 YP_977881.1 CDS fadD1 NC_008769.1 1983129 1984727 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(1983129..1984727) Mycobacterium bovis BCG str. Pasteur 1173P2 4697760 YP_977882.1 CDS BCG_1790 NC_008769.1 1984781 1986163 D Differs from Rv1751 by 2aa, T311M, L439V, and from Mb1780 by 1aa, T311M; hypothetical protein 1984781..1986163 Mycobacterium bovis BCG str. Pasteur 1173P2 4697776 YP_977883.1 CDS BCG_1791 NC_008769.1 1986290 1986739 D hypothetical protein 1986290..1986739 Mycobacterium bovis BCG str. Pasteur 1173P2 4696267 YP_977884.1 CDS PPE24 NC_008769.1 1986774 1989854 R In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, PPE24 differs in the 26 aa tandem repeat region, two copies less (in-frame deletion of 156 bp), and in the 25 aa repeat region, 2 and one more copies (in-frame insertion of 150bp and 75bp), respectively, compared to their homolog in Mycobacterium tuberculosis strain H37Rv; PPE family protein complement(1986774..1989854) Mycobacterium bovis BCG str. Pasteur 1173P2 4699275 YP_977885.1 CDS BCG_1793c NC_008769.1 1990058 1991749 R Differs from Rv1754c and Mb1783c by 1aa, S546N; hypothetical protein complement(1990058..1991749) Mycobacterium bovis BCG str. Pasteur 1173P2 4698630 YP_977886.1 CDS plcD NC_008769.1 1991933 1993477 R Truncated by RvD2 deletion (6804bp) in Mycobacterium tuberculosis strain H37Rv; phospholipase C 4 plcD complement(1991933..1993477) Mycobacterium bovis BCG str. Pasteur 1173P2 4696567 YP_977887.1 CDS BCG_1795c NC_008769.1 1993606 1994790 R No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to the RvD2 region; hypothetical protein complement(1993606..1994790) Mycobacterium bovis BCG str. Pasteur 1173P2 4695942 YP_977888.1 CDS BCG_1796 NC_008769.1 1994940 1996079 D No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to RvD2 region; sulfite oxidase 1994940..1996079 Mycobacterium bovis BCG str. Pasteur 1173P2 4695946 YP_977889.1 CDS mmpL14 NC_008769.1 1996280 1999117 D No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to RvD2 region; transmembrane transport protein mmpL14 1996280..1999117 Mycobacterium bovis BCG str. Pasteur 1173P2 4696122 YP_977890.1 CDS cut1 NC_008769.1 1999438 2000094 D Belongs to the RvD2 region. In Mycobacterium tuberculosis strain H37Rv, Rv1758 is interrupted by IS6110 insertion element and the 5'-end is deleted; cutinase cut1 1999438..2000094 Mycobacterium bovis BCG str. Pasteur 1173P2 4697544 YP_977891.1 CDS wag22b NC_008769.1 2000361 2002769 R In Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (c-*) splits wag22 into 2 parts, wag22a and wag22b. Differs from Mb1789c and Rv1759c by three deletions R129 replaced by AG, 5aa deletion at position 739 and 12aa deletion at position 777 making protein smaller (802 versus 820); PE-PGRS family protein complement(2000361..2002769) Mycobacterium bovis BCG str. Pasteur 1173P2 4697463 YP_977892.1 CDS wag22a NC_008769.1 2002766 2003050 R In Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (c-*) splits wag22 into 2 parts, wag22a and wag22b; PE-PGRS family protein complement(2002766..2003050) Mycobacterium bovis BCG str. Pasteur 1173P2 4697889 YP_977893.1 CDS BCG_1801 NC_008769.1 2003626 2005155 D In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; Also differs from Rv1760 by 1aa, V219E; hypothetical protein 2003626..2005155 Mycobacterium bovis BCG str. Pasteur 1173P2 4697888 YP_977894.1 CDS BCG_1802c NC_008769.1 2005143 2005526 R hypothetical protein complement(2005143..2005526) Mycobacterium bovis BCG str. Pasteur 1173P2 4696647 YP_977895.1 CDS BCG_1803c NC_008769.1 2005526 2006314 R hypothetical protein complement(2005526..2006314) Mycobacterium bovis BCG str. Pasteur 1173P2 4695529 YP_977896.1 CDS BCG_1804c NC_008769.1 2006454 2006921 R In Mycobacterium tuberculosis strain H37Rv this region is occupied by IS6110 which interrupts the gene and appears to have deleted sequences downstream. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, there is an 848bp sequence that has replaced a 121bp sequence corresponding to H37Rv positions 1997332-1997452; hypothetical protein complement(2006454..2006921) Mycobacterium bovis BCG str. Pasteur 1173P2 4697899 YP_977897.1 CDS BCG_1805c NC_008769.1 2007019 2007171 R In Mycobacterium tuberculosis strain H37Rv this region is occupied by IS6110 which appears to have deleted sequences downstream. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, there is an 848bp sequence that has replaced a 121bp sequence corresponding to H37Rv positions 1997332-1997452; hypothetical protein complement(2007019..2007171) Mycobacterium bovis BCG str. Pasteur 1173P2 4697950 YP_977898.1 CDS BCG_1806c NC_008769.1 2007332 2008771 R In Mycobacterium bovis BCG Pasteur, deletion of 9068 bp (region of difference RD14), compared to Mycobacterium tuberculosis H37Rv2 (position: 1998226..2007293) and Mycobacterium bovis AF2122/97 (position 1988666..1997751), removes genes Rv1765A-Rv1772 and merges truncated genes Rv1773c and Rv1765c; hypothetical protein complement(2007332..2008771) Mycobacterium bovis BCG str. Pasteur 1173P2 4695607 YP_977899.1 CDS BCG_1807 NC_008769.1 2008837 2010177 D oxidoreductase 2008837..2010177 Mycobacterium bovis BCG str. Pasteur 1173P2 4696474 YP_977900.1 CDS BCG_1808 NC_008769.1 2010177 2010995 D hypothetical protein 2010177..2010995 Mycobacterium bovis BCG str. Pasteur 1173P2 4695511 YP_977901.1 CDS BCG_1809c NC_008769.1 2011000 2011560 R transcriptional regulatory protein complement(2011000..2011560) Mycobacterium bovis BCG str. Pasteur 1173P2 4696077 YP_977902.1 CDS cyp144 NC_008769.1 2011661 2012965 D Differs from Rv1777 by 1aa Q325H; cytochrome p450 144 CYP144 2011661..2012965 Mycobacterium bovis BCG str. Pasteur 1173P2 4697618 YP_977903.1 CDS BCG_1811c NC_008769.1 2013086 2013535 R Differs from Rv1778c by 1aa T32R; hypothetical protein complement(2013086..2013535) Mycobacterium bovis BCG str. Pasteur 1173P2 4696758 YP_977904.1 CDS BCG_1812c NC_008769.1 2013691 2015484 R hypothetical protein complement(2013691..2015484) Mycobacterium bovis BCG str. Pasteur 1173P2 4696351 YP_977905.1 CDS BCG_1813 NC_008769.1 2015704 2016267 D hypothetical protein 2015704..2016267 Mycobacterium bovis BCG str. Pasteur 1173P2 4696603 YP_977906.1 CDS malQ NC_008769.1 2016307 2018481 R Differs from Rv1781c and Mb1810c by 1aa, T12A; 4-alpha-glucanotransferase malQ complement(2016307..2018481) Mycobacterium bovis BCG str. Pasteur 1173P2 4695401 YP_977907.1 CDS BCG_1815 NC_008769.1 2018745 2020265 D Differs from Rv1782 by 1aa H41R; hypothetical protein 2018745..2020265 Mycobacterium bovis BCG str. Pasteur 1173P2 4698307 YP_977908.1 CDS BCG_1816 NC_008769.1 2020262 2024437 D In Mycobacterium tuberculosis strain H37Rv, Rv1783 and Rv1784 exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base transversion (a-t) leads to a single product. Differs from Rv1783 and Mb1812 by 1aa, V692A, identical to Rv1784; hypothetical protein 2020262..2024437 Mycobacterium bovis BCG str. Pasteur 1173P2 4697385 YP_977909.1 CDS cyp143 NC_008769.1 2024452 2025633 R cytochrome P450 143 cyp143 complement(2024452..2025633) Mycobacterium bovis BCG str. Pasteur 1173P2 4697777 YP_977910.1 CDS BCG_1818 NC_008769.1 2025833 2026036 D ferredoxin 2025833..2026036 Mycobacterium bovis BCG str. Pasteur 1173P2 4695419 YP_977911.1 CDS PPE25 NC_008769.1 2026306 2027400 D In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 8 bp to 5 bp substitution (agcccggt-ccggg), leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (364 aa versus 365 aa). Identical to Mb1815; PPE family protein 2026306..2027400 Mycobacterium bovis BCG str. Pasteur 1173P2 4697046 YP_977912.1 CDS PE18 NC_008769.1 2027479 2027778 D PE family protein 2027479..2027778 Mycobacterium bovis BCG str. Pasteur 1173P2 4698631 YP_977913.1 CDS PPE26 NC_008769.1 2027792 2028973 D Differs from Mb1817 by 1aa, S274A, identical to Rv1789; PPE family protein 2027792..2028973 Mycobacterium bovis BCG str. Pasteur 1173P2 4699008 YP_977914.1 CDS PPE27 NC_008769.1 2029427 2030479 D Identical to Rv1790 differs from Mb1818 by 1aa, P190S; PPE family protein 2029427..2030479 Mycobacterium bovis BCG str. Pasteur 1173P2 4697681 YP_977915.1 CDS PE19 NC_008769.1 2030906 2031205 D PE family protein 2030906..2031205 Mycobacterium bovis BCG str. Pasteur 1173P2 4697682 YP_977916.1 CDS esxM NC_008769.1 2031349 2031645 D Differs from Rv1792 by 1aa Q48M; hypothetical protein 2031349..2031645 Mycobacterium bovis BCG str. Pasteur 1173P2 4699009 YP_977917.1 CDS esxN NC_008769.1 2031696 2031980 D ESAT-6 like protein 5 2031696..2031980 Mycobacterium bovis BCG str. Pasteur 1173P2 4695501 YP_977918.1 CDS BCG_1826 NC_008769.1 2032068 2032970 D hypothetical protein 2032068..2032970 Mycobacterium bovis BCG str. Pasteur 1173P2 4698771 YP_977919.1 CDS BCG_1827 NC_008769.1 2033242 2034753 D Differs from Mb1823 and Rv1795 by 1aa, T256A and D261G, respectively; hypothetical protein 2033242..2034753 Mycobacterium bovis BCG str. Pasteur 1173P2 4697393 YP_977920.1 CDS BCG_1828 NC_008769.1 2034731 2036488 D protease 2034731..2036488 Mycobacterium bovis BCG str. Pasteur 1173P2 4696743 YP_977921.1 CDS BCG_1829 NC_008769.1 2036485 2037705 D hypothetical protein 2036485..2037705 Mycobacterium bovis BCG str. Pasteur 1173P2 4697839 YP_977922.1 CDS BCG_1830 NC_008769.1 2037702 2039534 D hypothetical protein 2037702..2039534 Mycobacterium bovis BCG str. Pasteur 1173P2 4695994 YP_977923.1 CDS lppT NC_008769.1 2040161 2040352 D lipoprotein lppT 2040161..2040352 Mycobacterium bovis BCG str. Pasteur 1173P2 4696649 YP_977924.1 CDS PPE28 NC_008769.1 2040455 2042422 D Differs from Rv1800 by 3aa, W144C, V253F, V432I, and from Mb1828 by 1aa,V432I; PPE family protein 2040455..2042422 Mycobacterium bovis BCG str. Pasteur 1173P2 4698577 YP_977925.1 CDS PPE29 NC_008769.1 2043003 2044274 D PPE family protein 2043003..2044274 Mycobacterium bovis BCG str. Pasteur 1173P2 4697683 YP_977926.1 CDS PPE30 NC_008769.1 2044386 2045777 D PPE family protein 2044386..2045777 Mycobacterium bovis BCG str. Pasteur 1173P2 4697684 YP_977927.1 CDS PE_PGRS32b NC_008769.1 2045925 2047547 R In Mycobacterium tuberculosis strain H37Rv, PE_PGRS32 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base transition (c-t) splits PE_PGRS32 into 2 parts, PE_PGRS32a and PE_PGRS32b; PE-PGRS family protein complement(2045925..2047547) Mycobacterium bovis BCG str. Pasteur 1173P2 4697875 YP_977928.1 CDS PE_PGRS32a NC_008769.1 2047581 2047844 R In Mycobacterium tuberculosis strain H37Rv, PE_PGRS32 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base transition (c-t) splits PE_PGRS32 into 2 parts, PE_PGRS32a and PE_PGRS32b; PE-PGRS family protein complement(2047581..2047844) Mycobacterium bovis BCG str. Pasteur 1173P2 4696584 YP_977929.1 CDS BCG_1837c NC_008769.1 2048025 2048351 R hypothetical protein complement(2048025..2048351) Mycobacterium bovis BCG str. Pasteur 1173P2 4696583 YP_977930.1 CDS BCG_1838c NC_008769.1 2048689 2049036 R hypothetical protein complement(2048689..2049036) Mycobacterium bovis BCG str. Pasteur 1173P2 4697893 YP_977931.1 CDS PE20 NC_008769.1 2049074 2049373 D PE family protein 2049074..2049373 Mycobacterium bovis BCG str. Pasteur 1173P2 4697481 YP_977932.1 CDS PPE31 NC_008769.1 2049400 2050599 D Differs from Rv1807 by 2aa, S223F, L234V. Identical to Mb1836; PPE family protein 2049400..2050599 Mycobacterium bovis BCG str. Pasteur 1173P2 4699377 YP_977933.1 CDS PPE32 NC_008769.1 2050923 2052152 D Differs from Rv1808 by 1aa, A301G; PPE family protein 2050923..2052152 Mycobacterium bovis BCG str. Pasteur 1173P2 4697876 YP_977934.1 CDS PPE33a NC_008769.1 2052284 2052847 D In Mycobacterium tuberculosis strain H37Rv, PPE33 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base transition (c-t) splits PPE33 into 2 parts, PPE33a and PPE33b; PPE family protein 2052284..2052847 Mycobacterium bovis BCG str. Pasteur 1173P2 4697877 YP_977935.1 CDS BCG_1844 NC_008769.1 2053935 2054291 D hypothetical protein 2053935..2054291 Mycobacterium bovis BCG str. Pasteur 1173P2 4697879 YP_977936.1 CDS BCG_1845 NC_008769.1 2054445 2055149 D Mg2+ transporter 2054445..2055149 Mycobacterium bovis BCG str. Pasteur 1173P2 4697405 YP_977937.1 CDS BCG_1846c NC_008769.1 2055159 2056361 R Differs from Rv1812c by 1aa, P30L; dehydrogenase complement(2055159..2056361) Mycobacterium bovis BCG str. Pasteur 1173P2 4696226 YP_977938.1 CDS BCG_1847c NC_008769.1 2056683 2057114 R hypothetical protein complement(2056683..2057114) Mycobacterium bovis BCG str. Pasteur 1173P2 4696658 YP_977939.1 CDS erg3 NC_008769.1 2057523 2058425 D membrane-bound C-5 sterol desaturase erg3 2057523..2058425 Mycobacterium bovis BCG str. Pasteur 1173P2 4695700 YP_977940.1 CDS BCG_1849 NC_008769.1 2058530 2059195 D Differs from Rv1815 by 1aa, F83I; hypothetical protein 2058530..2059195 Mycobacterium bovis BCG str. Pasteur 1173P2 4698439 YP_977941.1 CDS BCG_1850 NC_008769.1 2059258 2059962 D transcriptional regulatory protein 2059258..2059962 Mycobacterium bovis BCG str. Pasteur 1173P2 4695524 YP_977943.1 CDS BCG_1852 NC_008769.1 2060597 2062060 D hypothetical protein 2060597..2062060 Mycobacterium bovis BCG str. Pasteur 1173P2 4696086 YP_977944.1 CDS PE_PGRS33 NC_008769.1 2062180 2063685 R In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 9 bp insertion (*-gccgccggc), leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (501 aa versus 498 aa). Differs from Rv1818c by 4aa, S233G, and deletion of 3aa near C-terminus. Identical to Mb1849c; PE-PGRS family protein complement(2062180..2063685) Mycobacterium bovis BCG str. Pasteur 1173P2 4697565 YP_977945.1 CDS BCG_1854c NC_008769.1 2063820 2065739 R Differs from Rv1819c by 1aa, V603I; drugs-transport transmembrane ATP-binding protein ABC transporter complement(2063820..2065739) Mycobacterium bovis BCG str. Pasteur 1173P2 4696585 YP_977946.1 CDS ilvG NC_008769.1 2065810 2067453 D hypothetical protein 2065810..2067453 Mycobacterium bovis BCG str. Pasteur 1173P2 4696074 YP_977947.1 CDS secA2 NC_008769.1 2067468 2069894 D SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 2067468..2069894 Mycobacterium bovis BCG str. Pasteur 1173P2 4698973 YP_977948.1 CDS pgsA2 NC_008769.1 2070091 2070720 D CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase pgsA2 2070091..2070720 Mycobacterium bovis BCG str. Pasteur 1173P2 4697705 YP_977949.1 CDS BCG_1858 NC_008769.1 2070713 2071636 D hypothetical protein 2070713..2071636 Mycobacterium bovis BCG str. Pasteur 1173P2 4698857 YP_977950.1 CDS BCG_1859 NC_008769.1 2071665 2072030 D hypothetical protein 2071665..2072030 Mycobacterium bovis BCG str. Pasteur 1173P2 4696546 YP_977951.1 CDS BCG_1860 NC_008769.1 2072047 2072925 D hypothetical protein 2072047..2072925 Mycobacterium bovis BCG str. Pasteur 1173P2 4696437 YP_977952.1 CDS gcvH NC_008769.1 2072963 2073367 D part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 2072963..2073367 Mycobacterium bovis BCG str. Pasteur 1173P2 4697131 YP_977953.1 CDS cfp17 NC_008769.1 2073607 2074095 D hypothetical protein 2073607..2074095 Mycobacterium bovis BCG str. Pasteur 1173P2 4696532 YP_977954.1 CDS BCG_1863 NC_008769.1 2074092 2074835 D hypothetical protein 2074092..2074835 Mycobacterium bovis BCG str. Pasteur 1173P2 4698290 YP_977955.1 CDS BCG_1864 NC_008769.1 2074954 2075448 D Differs from Rv1829 by 1aa R93C; hypothetical protein 2074954..2075448 Mycobacterium bovis BCG str. Pasteur 1173P2 4695409 YP_977956.1 CDS BCG_1865 NC_008769.1 2075796 2076473 D hypothetical protein 2075796..2076473 Mycobacterium bovis BCG str. Pasteur 1173P2 4696710 YP_977957.1 CDS BCG_1866 NC_008769.1 2076526 2076783 D hypothetical protein 2076526..2076783 Mycobacterium bovis BCG str. Pasteur 1173P2 4695609 YP_977958.1 CDS gcvB NC_008769.1 2076832 2079657 D acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 2076832..2079657 Mycobacterium bovis BCG str. Pasteur 1173P2 4696466 YP_977959.1 CDS BCG_1868c NC_008769.1 2079884 2080744 R haloalkane dehalogenase complement(2079884..2080744) Mycobacterium bovis BCG str. Pasteur 1173P2 4696531 YP_977960.1 CDS BCG_1869 NC_008769.1 2080785 2081651 D Differs from Mb1865 by 1aa, V272A; hydrolase 2080785..2081651 Mycobacterium bovis BCG str. Pasteur 1173P2 4696841 YP_977961.1 CDS BCG_1870c NC_008769.1 2081656 2083542 R hypothetical protein complement(2081656..2083542) Mycobacterium bovis BCG str. Pasteur 1173P2 4697356 YP_977962.1 CDS BCG_1871c NC_008769.1 2083558 2085591 R Differs from Rv1836c by 2aa, C137R, H591R; hypothetical protein complement(2083558..2085591) Mycobacterium bovis BCG str. Pasteur 1173P2 4697019 YP_977963.1 CDS glcB NC_008769.1 2085711 2087936 R catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G complement(2085711..2087936) Mycobacterium bovis BCG str. Pasteur 1173P2 4696985 YP_977964.1 CDS BCG_1873c NC_008769.1 2088212 2088607 R hypothetical protein complement(2088212..2088607) Mycobacterium bovis BCG str. Pasteur 1173P2 4697398 YP_977965.1 CDS BCG_1874c NC_008769.1 2088604 2088867 R hypothetical protein complement(2088604..2088867) Mycobacterium bovis BCG str. Pasteur 1173P2 4696248 YP_977966.1 CDS PE_PGRS34a NC_008769.1 2089654 2090472 R In Mycobacterium bovis, an in-frame deletion of 147 bp leads to a shorter protein compared to its homolog in Mycobacterium tuberculosis strain H37Rv (466 aa versus 518 aa). In Mycobacterium bovis BCG Pasteur a deletion of 1bp, splits PPE34 into 2 parts, PPE34a and PPE34b; PE-PGRS family protein complement(2089654..2090472) Mycobacterium bovis BCG str. Pasteur 1173P2 4698705 YP_977967.1 CDS BCG_1877c NC_008769.1 2090635 2091684 R In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 12 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (349 aa versus 345 aa); hypothetical protein complement(2090635..2091684) Mycobacterium bovis BCG str. Pasteur 1173P2 4696586 YP_977968.1 CDS BCG_1878c NC_008769.1 2091684 2093051 R Differs from Rv1842c by 1aa, S437L; hypothetical protein complement(2091684..2093051) Mycobacterium bovis BCG str. Pasteur 1173P2 4697024 YP_977969.1 CDS guaB1 NC_008769.1 2093225 2094664 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase complement(2093225..2094664) Mycobacterium bovis BCG str. Pasteur 1173P2 4696097 YP_977970.1 CDS gnd1 NC_008769.1 2094030 2096087 R catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase complement(2094030..2096087) Mycobacterium bovis BCG str. Pasteur 1173P2 4697815 YP_977971.1 CDS BCG_1881c NC_008769.1 2096177 2097127 R Differs from Rv1845c and Mb1876c by 1aa, A222V; hypothetical protein complement(2096177..2097127) Mycobacterium bovis BCG str. Pasteur 1173P2 4697622 YP_977972.1 CDS BCG_1882c NC_008769.1 2097142 2097558 R Differs from Rv1846c by 1aa, Y92D; transcriptional regulatory protein complement(2097142..2097558) Mycobacterium bovis BCG str. Pasteur 1173P2 4697281 YP_977973.1 CDS BCG_1883 NC_008769.1 2097836 2098258 D Differs from Rv1847 by 1aa, L90V; hypothetical protein 2097836..2098258 Mycobacterium bovis BCG str. Pasteur 1173P2 4696981 YP_977974.1 CDS ureA NC_008769.1 2098307 2098609 D UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 2098307..2098609 Mycobacterium bovis BCG str. Pasteur 1173P2 4697952 YP_977975.1 CDS ureB NC_008769.1 2098606 2098920 D ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); urease subunit beta 2098606..2098920 Mycobacterium bovis BCG str. Pasteur 1173P2 4696503 YP_977976.1 CDS ureC NC_008769.1 2098920 2100653 D ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 2098920..2100653 Mycobacterium bovis BCG str. Pasteur 1173P2 4696504 YP_977977.1 CDS ureF NC_008769.1 2100653 2101288 D Differs from Rv1851 by 1aa, L34V; urease accessory protein uref 2100653..2101288 Mycobacterium bovis BCG str. Pasteur 1173P2 4695765 YP_977978.1 CDS ureG NC_008769.1 2101299 2101973 D urease accessory protein ureG 2101299..2101973 Mycobacterium bovis BCG str. Pasteur 1173P2 4695767 YP_977979.1 CDS ureD NC_008769.1 2101981 2102607 D urease accessory protein ureD 2101981..2102607 Mycobacterium bovis BCG str. Pasteur 1173P2 4695768 YP_977980.1 CDS ndh NC_008769.1 2102610 2104001 R Differs from Rv1854c by 1aa, R313G, and Mb1885c by 2aa, R284W, R313G; NADH dehydrogenase ndh complement(2102610..2104001) Mycobacterium bovis BCG str. Pasteur 1173P2 4695766 YP_977981.1 CDS BCG_1891c NC_008769.1 2104142 2105065 R oxidoreductase complement(2104142..2105065) Mycobacterium bovis BCG str. Pasteur 1173P2 4696137 YP_977982.1 CDS BCG_1892c NC_008769.1 2105104 2105781 R Differs from Rv1856c by 1aa, H185R; short chain dehydrogenase complement(2105104..2105781) Mycobacterium bovis BCG str. Pasteur 1173P2 4696465 YP_977983.1 CDS modA NC_008769.1 2105943 2106728 D molybdate-binding lipoprotein modA 2105943..2106728 Mycobacterium bovis BCG str. Pasteur 1173P2 4695448 YP_977984.1 CDS modB NC_008769.1 2106731 2107525 D molbdenum-transport integral membrane protein ABC transporter modB 2106731..2107525 Mycobacterium bovis BCG str. Pasteur 1173P2 4695567 YP_977985.1 CDS modC NC_008769.1 2107532 2108641 D Differs from Rv1859 by 1aa, M313T; molybdenum-transport ATP-binding protein ABC transporter modC 2107532..2108641 Mycobacterium bovis BCG str. Pasteur 1173P2 4695568 YP_977986.1 CDS apa NC_008769.1 2108694 2109671 D Differs from Rv1860 by 1aa, L136F; hypothetical protein 2108694..2109671 Mycobacterium bovis BCG str. Pasteur 1173P2 4695569 YP_977987.1 CDS BCG_1897 NC_008769.1 2110123 2110428 D hypothetical protein 2110123..2110428 Mycobacterium bovis BCG str. Pasteur 1173P2 4695898 YP_977988.1 CDS adhA NC_008769.1 2110503 2111543 D alcohol dehydrogenase adhA 2110503..2111543 Mycobacterium bovis BCG str. Pasteur 1173P2 4695866 YP_977989.1 CDS BCG_1899c NC_008769.1 2111550 2112320 R integral membrane protein complement(2111550..2112320) Mycobacterium bovis BCG str. Pasteur 1173P2 4697831 YP_977990.1 CDS BCG_1900c NC_008769.1 2112313 2113068 R hypothetical protein complement(2112313..2113068) Mycobacterium bovis BCG str. Pasteur 1173P2 4696485 YP_977991.1 CDS BCG_1901c NC_008769.1 2113065 2113925 R short chain dehydrogenase complement(2113065..2113925) Mycobacterium bovis BCG str. Pasteur 1173P2 4697312 YP_977992.1 CDS BCG_1902 NC_008769.1 2114099 2116435 D Differs from Rv1866 by 1aa, Q17E; hypothetical protein 2114099..2116435 Mycobacterium bovis BCG str. Pasteur 1173P2 4697386 YP_977993.1 CDS BCG_1903 NC_008769.1 2116723 2118207 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 2116723..2118207 Mycobacterium bovis BCG str. Pasteur 1173P2 4697954 YP_977994.1 CDS BCG_1904 NC_008769.1 2118306 2120405 D Differs from Rv1868 and Mb1899 by 1aa, G621D; hypothetical protein 2118306..2120405 Mycobacterium bovis BCG str. Pasteur 1173P2 4697956 YP_977995.1 CDS BCG_1905c NC_008769.1 2120419 2121654 R Differs from Mb1900c and Rv1869c by 1aa, P4S; reductase complement(2120419..2121654) Mycobacterium bovis BCG str. Pasteur 1173P2 4695597 YP_977996.1 CDS BCG_1906c NC_008769.1 2121721 2122389 R In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base transversion (t-a) and a single base transition (c-t) lead to a slightly longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (222 aa versus 211 aa); hypothetical protein complement(2121721..2122389) Mycobacterium bovis BCG str. Pasteur 1173P2 4696353 YP_977997.1 CDS BCG_1907c NC_008769.1 2122454 2122843 R hypothetical protein complement(2122454..2122843) Mycobacterium bovis BCG str. Pasteur 1173P2 4696513 YP_977998.1 CDS lldD2 NC_008769.1 2122866 2124110 R Differs from Rv1872c by 2aa, A59G, A176V; L-lactate dehydrogenase (cytochrome) lldD2 complement(2122866..2124110) Mycobacterium bovis BCG str. Pasteur 1173P2 4696310 YP_977999.1 CDS BCG_1909 NC_008769.1 2124133 2124570 D Differs from Mb1904 by 1aa, D102N; hypothetical protein 2124133..2124570 Mycobacterium bovis BCG str. Pasteur 1173P2 4695786 YP_978000.1 CDS BCG_1910 NC_008769.1 2124643 2125329 D hypothetical protein 2124643..2125329 Mycobacterium bovis BCG str. Pasteur 1173P2 4697473 YP_978001.1 CDS BCG_1911 NC_008769.1 2125340 2125783 D hypothetical protein 2125340..2125783 Mycobacterium bovis BCG str. Pasteur 1173P2 4695382 YP_978002.1 CDS bfrA NC_008769.1 2126299 2126778 D bacterioferritin bfrA 2126299..2126778 Mycobacterium bovis BCG str. Pasteur 1173P2 4695595 YP_978003.1 CDS BCG_1913 NC_008769.1 2126863 2128398 D In Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-c), splits Rv1877 into 2 parts; integral membrane protein 2126863..2128398 Mycobacterium bovis BCG str. Pasteur 1173P2 4696093 YP_978004.1 CDS BCG_1914 NC_008769.1 2127713 2128927 D In Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-c), splits Rv1877 into 2 parts; integral membrane protein 2127713..2128927 Mycobacterium bovis BCG str. Pasteur 1173P2 4697828 YP_978005.1 CDS glnA3 NC_008769.1 2128982 2130334 D Identical to Rv1878, differs from Mb1910 by 1aa, A275T; glutamine synthetase glnA3 2128982..2130334 Mycobacterium bovis BCG str. Pasteur 1173P2 4696544 YP_978006.1 CDS BCG_1916 NC_008769.1 2130337 2131473 D hypothetical protein 2130337..2131473 Mycobacterium bovis BCG str. Pasteur 1173P2 4696211 YP_978007.1 CDS cyp140 NC_008769.1 2131501 2132817 R cytochrome p450 140 CYP140 complement(2131501..2132817) Mycobacterium bovis BCG str. Pasteur 1173P2 4695645 YP_978008.1 CDS lppE NC_008769.1 2132867 2133289 R lipoprotein lppE complement(2132867..2133289) Mycobacterium bovis BCG str. Pasteur 1173P2 4696037 YP_978009.1 CDS BCG_1919c NC_008769.1 2133330 2134163 R short chain dehydrogenase complement(2133330..2134163) Mycobacterium bovis BCG str. Pasteur 1173P2 4696494 YP_978010.1 CDS BCG_1920c NC_008769.1 2134191 2134667 R In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 15 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (158 aa versus 153 aa); hypothetical protein complement(2134191..2134667) Mycobacterium bovis BCG str. Pasteur 1173P2 4696723 YP_978011.1 CDS rpfC NC_008769.1 2134706 2135236 R resuscitation-promoting factor rpfC complement(2134706..2135236) Mycobacterium bovis BCG str. Pasteur 1173P2 4697500 YP_978012.1 CDS BCG_1922c NC_008769.1 2135248 2135847 R catalyzes the interconversion of chorismate to prephenate; chorismate mutase complement(2135248..2135847) Mycobacterium bovis BCG str. Pasteur 1173P2 4697714 YP_978013.1 CDS fbpB NC_008769.1 2135865 2136842 R Differs from Rv1886c and Mb1918c by 1aa, L140F; hypothetical protein complement(2135865..2136842) Mycobacterium bovis BCG str. Pasteur 1173P2 4698323 YP_978014.1 CDS BCG_1924 NC_008769.1 2137233 2138375 D Differs from Rv1887 and Mb1919 by 1aa, C121Y; hypothetical protein 2137233..2138375 Mycobacterium bovis BCG str. Pasteur 1173P2 4696565 YP_978015.1 CDS BCG_1925c NC_008769.1 2138345 2139064 R In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 10 bp insertion (*-tccgatcacc) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv (239 aa versus 186 aa); hypothetical protein complement(2138345..2139064) Mycobacterium bovis BCG str. Pasteur 1173P2 4697595 YP_978016.1 CDS BCG_1926c NC_008769.1 2139429 2139602 R hypothetical protein complement(2139429..2139602) Mycobacterium bovis BCG str. Pasteur 1173P2 4697826 YP_978017.1 CDS BCG_1927c NC_008769.1 2139646 2140002 R hypothetical protein complement(2139646..2140002) Mycobacterium bovis BCG str. Pasteur 1173P2 4695819 YP_978018.1 CDS BCG_1928c NC_008769.1 2140061 2140672 R hypothetical protein complement(2140061..2140672) Mycobacterium bovis BCG str. Pasteur 1173P2 4697783 YP_978019.1 CDS BCG_1929 NC_008769.1 2140726 2141133 D hypothetical protein 2140726..2141133 Mycobacterium bovis BCG str. Pasteur 1173P2 4695847 YP_978020.1 CDS BCG_1930 NC_008769.1 2141150 2141461 D hypothetical protein 2141150..2141461 Mycobacterium bovis BCG str. Pasteur 1173P2 4697779 YP_978021.1 CDS BCG_1931 NC_008769.1 2141471 2141689 D hypothetical protein 2141471..2141689 Mycobacterium bovis BCG str. Pasteur 1173P2 4695933 YP_978022.1 CDS BCG_1932c NC_008769.1 2141724 2142854 R hypothetical protein complement(2141724..2142854) Mycobacterium bovis BCG str. Pasteur 1173P2 4695455 YP_978023.1 CDS BCG_1933 NC_008769.1 2143506 2143829 D In Mycobacterium tuberculosis strain H37Rv, Rv1895 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, two frameshifts due to a single base deletion (a-*) and a single base insertion (*-t), consecutively, splits Rv1895 into 2 main parts; dehydrogenase 2143506..2143829 Mycobacterium bovis BCG str. Pasteur 1173P2 4697389 YP_978024.1 CDS BCG_1934 NC_008769.1 2143826 2144530 D In Mycobacterium tuberculosis strain H37Rv, Rv1895 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, two frameshifts due to a single base deletion (a-*) and a single base insertion (*-t), consecutively, splits Rv1895 into 2 main parts, Mb1928 and Mb1929; dehydrogenase 2143826..2144530 Mycobacterium bovis BCG str. Pasteur 1173P2 4697836 YP_978025.1 CDS BCG_1935c NC_008769.1 2144520 2145431 R hypothetical protein complement(2144520..2145431) Mycobacterium bovis BCG str. Pasteur 1173P2 4697703 YP_978026.1 CDS BCG_1936c NC_008769.1 2145436 2145867 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(2145436..2145867) Mycobacterium bovis BCG str. Pasteur 1173P2 4698364 YP_978027.1 CDS BCG_1937 NC_008769.1 2145925 2146233 D hypothetical protein 2145925..2146233 Mycobacterium bovis BCG str. Pasteur 1173P2 4696540 YP_978028.1 CDS lppD NC_008769.1 2146199 2147275 R In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (358 aa versus 343 aa); lipoprotein lppD complement(2146199..2147275) Mycobacterium bovis BCG str. Pasteur 1173P2 4697516 YP_978029.1 CDS lipJ NC_008769.1 2147275 2148663 R Differs from Rv1900c and Mb1935c by 1aa, M204I and R170Q, respectively; lignin peroxidase lipJ complement(2147275..2148663) Mycobacterium bovis BCG str. Pasteur 1173P2 4699202 YP_978030.1 CDS cinA NC_008769.1 2148692 2149984 D competence damage-inducible protein A 2148692..2149984 Mycobacterium bovis BCG str. Pasteur 1173P2 4698632 YP_978031.1 CDS nanT NC_008769.1 2150036 2151304 R sialic acid-transport integral membrane protein nanT complement(2150036..2151304) Mycobacterium bovis BCG str. Pasteur 1173P2 4698349 YP_978032.1 CDS BCG_1942 NC_008769.1 2151394 2151798 D hypothetical protein 2151394..2151798 Mycobacterium bovis BCG str. Pasteur 1173P2 4696618 YP_978033.1 CDS BCG_1943 NC_008769.1 2151984 2152415 D Differs from Rv1904 by 1aa, M130T; hypothetical protein 2151984..2152415 Mycobacterium bovis BCG str. Pasteur 1173P2 4697409 YP_978034.1 CDS aao NC_008769.1 2152463 2153425 R Differs from Rv1905c by 1aa, T240P; D-amino acid oxidase aao complement(2152463..2153425) Mycobacterium bovis BCG str. Pasteur 1173P2 4695380 YP_978035.1 CDS BCG_1945c NC_008769.1 2153455 2153925 R hypothetical protein complement(2153455..2153925) Mycobacterium bovis BCG str. Pasteur 1173P2 4697430 YP_978036.1 CDS BCG_1946c NC_008769.1 2154265 2154912 R hypothetical protein complement(2154265..2154912) Mycobacterium bovis BCG str. Pasteur 1173P2 4695366 YP_978037.1 CDS katG NC_008769.1 2154919 2157141 R Differs from Rv1908c by 1aa, L463R; catalase-peroxidase-peroxynitritase T katG complement(2154919..2157141) Mycobacterium bovis BCG str. Pasteur 1173P2 4695391 YP_978038.1 CDS furA NC_008769.1 2157179 2157631 R Differs from Rv1909c and Mb1944c by 1aa, V46A; ferric uptake regulation protein furA complement(2157179..2157631) Mycobacterium bovis BCG str. Pasteur 1173P2 4697351 YP_978039.1 CDS BCG_1949c NC_008769.1 2157736 2158329 R hypothetical protein complement(2157736..2158329) Mycobacterium bovis BCG str. Pasteur 1173P2 4695504 YP_978040.1 CDS lppC NC_008769.1 2158412 2159017 R lipoprotein lppC complement(2158412..2159017) Mycobacterium bovis BCG str. Pasteur 1173P2 4698446 YP_978041.1 CDS fadB5 NC_008769.1 2159117 2160121 R Differs from Rv1912c by 1aa, G328D; oxidoreductase fadB5 complement(2159117..2160121) Mycobacterium bovis BCG str. Pasteur 1173P2 4699201 YP_978042.1 CDS BCG_1952 NC_008769.1 2160221 2160973 D Differs from Rv1913 and Mb1948 by 1aa, C7R; hypothetical protein 2160221..2160973 Mycobacterium bovis BCG str. Pasteur 1173P2 4697104 YP_978043.1 CDS BCG_1953c NC_008769.1 2160951 2161358 R hypothetical protein complement(2160951..2161358) Mycobacterium bovis BCG str. Pasteur 1173P2 4697533 YP_978044.1 CDS aceA NC_008769.1 2161493 2163793 D In Mycobacterium tuberculosis strain H37Rv, aceAa and aceAb exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base insertion (*-t) leads to a single product; isocitrate lyase aceA 2161493..2163793 Mycobacterium bovis BCG str. Pasteur 1173P2 4695403 YP_978045.1 CDS PPE34 NC_008769.1 2163963 2169470 R Equivalent to Mb1951c and Rv1917c but differs by several in-frame insertion and deletion events. Differs from Mb1951c by 69 bp insertion, 69 bp deletion and 225 bp deletion. Differs from Rv1917c by deletions of 12 and 138 bp, insertions of 552 and 150 bp, and substitution of 52 bp by 628 bp; PPE family protein complement(2163963..2169470) Mycobacterium bovis BCG str. Pasteur 1173P2 4698950 YP_978046.1 CDS PPE35a NC_008769.1 2170895 2172772 R In Mycobacterium tuberculosis strain H37Rv, PPE35 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-t) splits PPE35 into 2 parts, PPE35a and PPE35b. Differs from Mb1953c by 1aa, F565V; PPE family protein complement(2170895..2172772) Mycobacterium bovis BCG str. Pasteur 1173P2 4696450 YP_978047.1 CDS BCG_1958c NC_008769.1 2173221 2173685 R hypothetical protein complement(2173221..2173685) Mycobacterium bovis BCG str. Pasteur 1173P2 4696449 YP_978048.1 CDS BCG_1959 NC_008769.1 2173783 2174646 D Differs from Rv1920 by 1aa, I130M; hypothetical protein 2173783..2174646 Mycobacterium bovis BCG str. Pasteur 1173P2 4698656 YP_978049.1 CDS lppF NC_008769.1 2174684 2175955 R lipoprotein lppF complement(2174684..2175955) Mycobacterium bovis BCG str. Pasteur 1173P2 4699375 YP_978050.1 CDS BCG_1961 NC_008769.1 2176227 2177342 D lipoprotein 2176227..2177342 Mycobacterium bovis BCG str. Pasteur 1173P2 4696495 YP_978051.1 CDS lipD NC_008769.1 2177333 2178673 D Differs from Rv1923 by 2aa, D73G, N181D; lipase lipD 2177333..2178673 Mycobacterium bovis BCG str. Pasteur 1173P2 4697421 YP_978052.1 CDS BCG_1963c NC_008769.1 2178710 2179090 R hypothetical protein complement(2178710..2179090) Mycobacterium bovis BCG str. Pasteur 1173P2 4698689 YP_978053.1 CDS fadD31 NC_008769.1 2179247 2181109 D activates fatty acids by binding to coenzyme A; fatty-acid--CoA ligase 2179247..2181109 Mycobacterium bovis BCG str. Pasteur 1173P2 4695416 YP_978054.1 CDS mpt63 NC_008769.1 2181117 2181596 R immunogenic protein mpt63 complement(2181117..2181596) Mycobacterium bovis BCG str. Pasteur 1173P2 4697645 YP_978055.1 CDS BCG_1966 NC_008769.1 2181833 2182606 D hypothetical protein 2181833..2182606 Mycobacterium bovis BCG str. Pasteur 1173P2 4698094 YP_978056.1 CDS BCG_1967c NC_008769.1 2182610 2183377 R short chain dehydrogenase complement(2182610..2183377) Mycobacterium bovis BCG str. Pasteur 1173P2 4695456 YP_978057.1 CDS BCG_1968c NC_008769.1 2183422 2184066 R hypothetical protein complement(2183422..2184066) Mycobacterium bovis BCG str. Pasteur 1173P2 4695446 YP_978058.1 CDS BCG_1969c NC_008769.1 2184078 2184602 R hypothetical protein complement(2184078..2184602) Mycobacterium bovis BCG str. Pasteur 1173P2 4698059 YP_978059.1 CDS BCG_1970c NC_008769.1 2184620 2185399 R transcriptional regulatory protein complement(2184620..2185399) Mycobacterium bovis BCG str. Pasteur 1173P2 4695353 YP_978060.1 CDS tpx NC_008769.1 2185532 2186029 D antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 2185532..2186029 Mycobacterium bovis BCG str. Pasteur 1173P2 4695644 YP_978061.1 CDS fadE18 NC_008769.1 2186026 2187117 R acyl-CoA dehydrogenase fadE18 complement(2186026..2187117) Mycobacterium bovis BCG str. Pasteur 1173P2 4696390 YP_978062.1 CDS fadE17 NC_008769.1 2187119 2188348 R acyl-CoA dehydrogenase fadE17 complement(2187119..2188348) Mycobacterium bovis BCG str. Pasteur 1173P2 4697445 YP_978063.1 CDS echA13 NC_008769.1 2188363 2189319 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(2188363..2189319) Mycobacterium bovis BCG str. Pasteur 1173P2 4697444 YP_978064.1 CDS BCG_1975 NC_008769.1 2189544 2190653 D monooxygenase 2189544..2190653 Mycobacterium bovis BCG str. Pasteur 1173P2 4697098 YP_978065.1 CDS BCG_1976 NC_008769.1 2190656 2193175 D oxygenase 2190656..2193175 Mycobacterium bovis BCG str. Pasteur 1173P2 4696262 YP_978066.1 CDS ephB NC_008769.1 2193187 2194257 D epoxide hydrolase ephB 2193187..2194257 Mycobacterium bovis BCG str. Pasteur 1173P2 4695500 YP_978067.1 CDS BCG_1978 NC_008769.1 2194254 2194769 D In Mycobacterium bovis, a single base deletion (t-*) leads to a longer product with a different COOH part compared to its homologs in Mycobacterium tuberculosis H37Rv and Mycobacterium bovis BCG Pasteur (244 aa versus 171 aa); oxidoreductase 2194254..2194769 Mycobacterium bovis BCG str. Pasteur 1173P2 4697908 YP_978068.1 CDS ribA1 NC_008769.1 2194766 2195827 D riboflavin biosynthesis protein ribA1 (GTP cyclohydrolase II) 2194766..2195827 Mycobacterium bovis BCG str. Pasteur 1173P2 4695447 YP_978069.1 CDS BCG_1980 NC_008769.1 2195824 2196594 D short-chain type dehydrogenase/reductase 2195824..2196594 Mycobacterium bovis BCG str. Pasteur 1173P2 4696888 YP_978070.1 CDS BCG_1981c NC_008769.1 2196804 2197133 R hypothetical protein complement(2196804..2197133) Mycobacterium bovis BCG str. Pasteur 1173P2 4695738 YP_978071.1 CDS BCG_1982c NC_008769.1 2197130 2197507 R hypothetical protein complement(2197130..2197507) Mycobacterium bovis BCG str. Pasteur 1173P2 4695576 YP_978072.1 CDS BCG_1983c NC_008769.1 2197504 2198094 R Differs from Rv1944c and Mb1979c by 2aa, E4D, A5T, due to 2 bp substitution ta-cc; hypothetical protein complement(2197504..2198094) Mycobacterium bovis BCG str. Pasteur 1173P2 4696412 YP_978073.1 CDS BCG_1984 NC_008769.1 2198149 2199513 D Differs from Mb1980 and Rv1945 by substitutions of 44, 29, 2, 10 and 34 bp, or 44, 29, 4, 2, 10 and 34 bp, respectively. Corresponding to 10 aa from Rv1945, L242V, N264H, A267G, F268L, A271G, K285R, I291V, N328H, H417K and P426A, and to 9 aa from MB1980, N264H, A267G, F268L, A271G, K285R, I291V, N328H, H417K and P426A; hypothetical protein 2198149..2199513 Mycobacterium bovis BCG str. Pasteur 1173P2 4698225 YP_978074.1 CDS lppG NC_008769.1 2199668 2200120 R Differs from Rv1946c by 1aa, T98A; lipoprotein complement(2199668..2200120) Mycobacterium bovis BCG str. Pasteur 1173P2 4696744 YP_978075.1 CDS BCG_1986 NC_008769.1 2200184 2200585 D hypothetical protein 2200184..2200585 Mycobacterium bovis BCG str. Pasteur 1173P2 4696496 YP_978076.1 CDS BCG_1987c NC_008769.1 2200874 2201224 R Differs from Rv1948c by 1aa, R5G; hypothetical protein complement(2200874..2201224) Mycobacterium bovis BCG str. Pasteur 1173P2 4696135 YP_978077.1 CDS BCG_1988c NC_008769.1 2201235 2202137 R Differs from Rv1949c by 1aa, L188F; hypothetical protein complement(2201235..2202137) Mycobacterium bovis BCG str. Pasteur 1173P2 4698911 YP_978078.1 CDS BCG_1989c NC_008769.1 2202158 2202349 R hypothetical protein complement(2202158..2202349) Mycobacterium bovis BCG str. Pasteur 1173P2 4697182 YP_978079.1 CDS BCG_1990c NC_008769.1 2202350 2202646 R hypothetical protein complement(2202350..2202646) Mycobacterium bovis BCG str. Pasteur 1173P2 4696896 YP_978080.1 CDS BCG_1991 NC_008769.1 2202886 2203101 D hypothetical protein 2202886..2203101 Mycobacterium bovis BCG str. Pasteur 1173P2 4697217 YP_978081.1 CDS BCG_1992 NC_008769.1 2203098 2203409 D hypothetical protein 2203098..2203409 Mycobacterium bovis BCG str. Pasteur 1173P2 4697670 YP_978082.1 CDS BCG_1993c NC_008769.1 2203383 2203904 R Differs from Rv1954c by 1aa, R150H; hypothetical protein complement(2203383..2203904) Mycobacterium bovis BCG str. Pasteur 1173P2 4697133 YP_978083.1 CDS BCG_1994 NC_008769.1 2203744 2204256 D hypothetical protein 2203744..2204256 Mycobacterium bovis BCG str. Pasteur 1173P2 4697512 YP_978084.1 CDS BCG_1995 NC_008769.1 2204298 2204747 D transcriptional regulatory protein 2204298..2204747 Mycobacterium bovis BCG str. Pasteur 1173P2 4697321 YP_978085.1 CDS BCG_1996 NC_008769.1 2204744 2205289 D hypothetical protein 2204744..2205289 Mycobacterium bovis BCG str. Pasteur 1173P2 4697449 YP_978086.1 CDS BCG_1997c NC_008769.1 2205178 2205792 R hypothetical protein complement(2205178..2205792) Mycobacterium bovis BCG str. Pasteur 1173P2 4697766 YP_978087.1 CDS BCG_1998c NC_008769.1 2205841 2206137 R hypothetical protein complement(2205841..2206137) Mycobacterium bovis BCG str. Pasteur 1173P2 4698064 YP_978088.1 CDS BCG_1999c NC_008769.1 2206134 2206385 R hypothetical protein complement(2206134..2206385) Mycobacterium bovis BCG str. Pasteur 1173P2 4699260 YP_978089.1 CDS BCG_2000 NC_008769.1 2206372 2206866 D hypothetical protein 2206372..2206866 Mycobacterium bovis BCG str. Pasteur 1173P2 4697773 YP_978090.1 CDS BCG_2001c NC_008769.1 2207026 2207433 R hypothetical protein complement(2207026..2207433) Mycobacterium bovis BCG str. Pasteur 1173P2 4699089 YP_978091.1 CDS BCG_2001A NC_008769.1 2207437 2207709 R antitoxin complement(2207437..2207709) Mycobacterium bovis BCG str. Pasteur 1173P2 4698013 YP_978092.1 CDS BCG_2002c NC_008769.1 2207742 2208962 R transcriptional regulatory protein complement(2207742..2208962) Mycobacterium bovis BCG str. Pasteur 1173P2 4698027 YP_978093.1 CDS yrbE3A NC_008769.1 2209861 2210265 D In Mycobacterium bovis an in Mycobacterium bovis BCG Pasteur, a large deletion of 12719 bp (RD7) leads to the loss of the COOH part of Rv1964|yrbE3A, the entire mce3 operon and the following genes up to Rv1978, compared to Mycobacterium tuberculosis strain H37Rv. Follow by a second deletion of 10287bp, RD2 region (only in Mycobacterium bovis BCG Pasteur), which removes genes Rv1979c-Rv1787 and merges truncated part of Rv1978 and Rv1988 compared to Mycobacterium tuberculosis strain H37Rv; integral membrane protein YrbE3a 2209861..2210265 Mycobacterium bovis BCG str. Pasteur 1173P2 4699329 YP_978094.1 CDS BCG_2004 NC_008769.1 2210350 2210874 D In Mycobacterium bovis BCG Pasteur, a large deletion of 10787 bp, RD2, removes genes Rv1979c-Rv1987 and merges truncated part of Rv1978 and Rv1988 compared to Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis AF2122/97; methyltransferase 2210350..2210874 Mycobacterium bovis BCG str. Pasteur 1173P2 4695513 YP_978095.1 CDS BCG_2005c NC_008769.1 2211394 2211954 R hypothetical protein complement(2211394..2211954) Mycobacterium bovis BCG str. Pasteur 1173P2 4698763 YP_978096.1 CDS BCG_2006c NC_008769.1 2211951 2212292 R transcriptional regulatory protein complement(2211951..2212292) Mycobacterium bovis BCG str. Pasteur 1173P2 4698530 YP_978097.1 CDS BCG_2007c NC_008769.1 2212536 2212871 R dehydrogenase complement(2212536..2212871) Mycobacterium bovis BCG str. Pasteur 1173P2 4698927 YP_978098.1 CDS BCG_2008c NC_008769.1 2212960 2213304 R hypothetical protein complement(2212960..2213304) Mycobacterium bovis BCG str. Pasteur 1173P2 4698489 YP_978099.1 CDS ctpG NC_008769.1 2213646 2215961 R metal cation transporter P-type atpase G ctpG complement(2213646..2215961) Mycobacterium bovis BCG str. Pasteur 1173P2 4698502 YP_978100.1 CDS BCG_2010c NC_008769.1 2215958 2216230 R hypothetical protein complement(2215958..2216230) Mycobacterium bovis BCG str. Pasteur 1173P2 4696427 YP_978101.1 CDS BCG_2011c NC_008769.1 2216283 2216639 R transcriptional regulatory protein complement(2216283..2216639) Mycobacterium bovis BCG str. Pasteur 1173P2 4698000 YP_978102.1 CDS BCG_2012 NC_008769.1 2216796 2217563 D hypothetical protein 2216796..2217563 Mycobacterium bovis BCG str. Pasteur 1173P2 4697915 YP_978103.1 CDS BCG_2013 NC_008769.1 2217659 2218612 D hypothetical protein 2217659..2218612 Mycobacterium bovis BCG str. Pasteur 1173P2 4698052 YP_978104.1 CDS ctpF NC_008769.1 2218814 2221531 D Differs from Rv1997 and Mb2020 by 1aa, D138E; metal cation transporter P-type atpase A ctpF 2218814..2221531 Mycobacterium bovis BCG str. Pasteur 1173P2 4697934 YP_978105.1 CDS BCG_2015c NC_008769.1 2221600 2222376 R Differs from Rv1998c by 1aa, R230S; hypothetical protein complement(2221600..2222376) Mycobacterium bovis BCG str. Pasteur 1173P2 4695897 YP_978106.1 CDS BCG_2016c NC_008769.1 2222471 2223793 R integral membrane protein complement(2222471..2223793) Mycobacterium bovis BCG str. Pasteur 1173P2 4698456 YP_978107.1 CDS BCG_2017 NC_008769.1 2223864 2225477 D hypothetical protein 2223864..2225477 Mycobacterium bovis BCG str. Pasteur 1173P2 4698476 YP_978108.1 CDS BCG_2018 NC_008769.1 2225487 2226239 D Differs from Rv2001 by 1aa, H113R; hypothetical protein 2225487..2226239 Mycobacterium bovis BCG str. Pasteur 1173P2 4698480 YP_978109.1 CDS fabG3 NC_008769.1 2226315 2227097 D 20-beta-hydroxysteroid dehydrogenase fabG3 2226315..2227097 Mycobacterium bovis BCG str. Pasteur 1173P2 4698258 YP_978110.1 CDS BCG_2020c NC_008769.1 2227218 2228075 R hypothetical protein complement(2227218..2228075) Mycobacterium bovis BCG str. Pasteur 1173P2 4696227 YP_978111.1 CDS BCG_2021c NC_008769.1 2228133 2229629 R hypothetical protein complement(2228133..2229629) Mycobacterium bovis BCG str. Pasteur 1173P2 4698344 YP_978112.1 CDS BCG_2022c NC_008769.1 2229651 2230538 R hypothetical protein complement(2229651..2230538) Mycobacterium bovis BCG str. Pasteur 1173P2 4697401 YP_978113.1 CDS otsB1 NC_008769.1 2230657 2234640 D Differs from Rv2006 and Mb2029 by 1aa, S80G and L1245P, respectively; trehalose-6-phosphate phosphatase otsB1 2230657..2234640 Mycobacterium bovis BCG str. Pasteur 1173P2 4697416 YP_978114.1 CDS fdxA NC_008769.1 2234739 2235083 R ferredoxin fdxA complement(2234739..2235083) Mycobacterium bovis BCG str. Pasteur 1173P2 4698923 YP_978115.1 CDS BCG_2025c NC_008769.1 2235272 2236597 R hypothetical protein complement(2235272..2236597) Mycobacterium bovis BCG str. Pasteur 1173P2 4696526 YP_978116.1 CDS BCG_2026 NC_008769.1 2236685 2236927 D Differs from Rv2009 by 1aa, D63N; hypothetical protein 2236685..2236927 Mycobacterium bovis BCG str. Pasteur 1173P2 4697410 YP_978117.1 CDS BCG_2027 NC_008769.1 2236928 2237326 D hypothetical protein 2236928..2237326 Mycobacterium bovis BCG str. Pasteur 1173P2 4696507 YP_978118.1 CDS BCG_2028c NC_008769.1 2237509 2237940 R hypothetical protein complement(2237509..2237940) Mycobacterium bovis BCG str. Pasteur 1173P2 4698188 YP_978119.1 CDS BCG_2029 NC_008769.1 2237981 2238475 D hypothetical protein 2237981..2238475 Mycobacterium bovis BCG str. Pasteur 1173P2 4697392 YP_978120.1 CDS BCG_2030 NC_008769.1 2239179 2239796 D In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base transition (c-t) at the 5' start, leads to a longer product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (206 aa versus 159 aa); transposase 2239179..2239796 Mycobacterium bovis BCG str. Pasteur 1173P2 4696130 YP_978121.1 CDS BCG_2031 NC_008769.1 2239750 2240340 D Identical to Mb2037 including extra 5 aa at C-terminus compared to Rv2014; transposase 2239750..2240340 Mycobacterium bovis BCG str. Pasteur 1173P2 4698598 YP_978122.1 CDS BCG_2032c NC_008769.1 2240468 2241724 R Differs from Mb2038c by 1aa S59L; hypothetical protein complement(2240468..2241724) Mycobacterium bovis BCG str. Pasteur 1173P2 4697391 YP_978123.1 CDS BCG_2033 NC_008769.1 2242078 2242653 D hypothetical protein 2242078..2242653 Mycobacterium bovis BCG str. Pasteur 1173P2 4695370 YP_978124.1 CDS BCG_2034 NC_008769.1 2242650 2243690 D Differs from Rv2017 by 1aa, E262A; regulatory protein 2242650..2243690 Mycobacterium bovis BCG str. Pasteur 1173P2 4695867 YP_978125.1 CDS BCG_2035 NC_008769.1 2243932 2244651 D Differs from Rv2018 by 1aa, G116D; hypothetical protein 2243932..2244651 Mycobacterium bovis BCG str. Pasteur 1173P2 4696328 YP_978126.1 CDS BCG_2036 NC_008769.1 2244641 2245057 D hypothetical protein 2244641..2245057 Mycobacterium bovis BCG str. Pasteur 1173P2 4698882 YP_978127.1 CDS BCG_2037c NC_008769.1 2245073 2245372 R hypothetical protein complement(2245073..2245372) Mycobacterium bovis BCG str. Pasteur 1173P2 4699004 YP_978128.1 CDS BCG_2038c NC_008769.1 2245457 2245762 R hypothetical protein complement(2245457..2245762) Mycobacterium bovis BCG str. Pasteur 1173P2 4698829 YP_978129.1 CDS BCG_2039c NC_008769.1 2245771 2246376 R hypothetical protein complement(2245771..2246376) Mycobacterium bovis BCG str. Pasteur 1173P2 4696410 YP_978130.1 CDS BCG_2040c NC_008769.1 2246401 2246760 R hypothetical protein complement(2246401..2246760) Mycobacterium bovis BCG str. Pasteur 1173P2 4698654 YP_978131.1 CDS BCG_2041c NC_008769.1 2246920 2247597 R Belongs to the RvD1 region. Absent in Mycobacterium tuberculosis strain H37Rv; hypothetical protein complement(2246920..2247597) Mycobacterium bovis BCG str. Pasteur 1173P2 4698711 YP_978132.1 CDS BCG_2042c NC_008769.1 2247992 2248888 R Belongs to the RvD1 region. Absent in Mycobacterium tuberculosis strain H37Rv; Differs from Mb2048c by 1aa, E139K; hypothetical protein complement(2247992..2248888) Mycobacterium bovis BCG str. Pasteur 1173P2 4699084 YP_978133.1 CDS BCG_2043c NC_008769.1 2249072 2253892 R In Mycobacterium tuberculosis strain H37Rv, a large deletion region (RvD1) exists in between Rv2023 and Rv2024. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 5000 bp insertion at this region results in Mb2049c being a much larger product with a different COOH part (1606 aa versus 515 aa), and in 2 extra genes, Mb2046c and Mb2047c; Differs from N-terminal part of Rv2024c (truncated by RvD1) by 3aa, R47W, G154D, C289R and Mb2049c by 1aa, F341V; hypothetical protein complement(2249072..2253892) Mycobacterium bovis BCG str. Pasteur 1173P2 4698652 YP_978134.1 CDS BCG_2044c NC_008769.1 2254402 2255400 R hypothetical protein complement(2254402..2255400) Mycobacterium bovis BCG str. Pasteur 1173P2 4697333 YP_978135.1 CDS BCG_2045c NC_008769.1 2255515 2256399 R hypothetical protein complement(2255515..2256399) Mycobacterium bovis BCG str. Pasteur 1173P2 4695736 YP_978136.1 CDS BCG_2046c NC_008769.1 2256439 2258160 R Differs from Rv2027c by 1aa, V15L; histidine kinase response regulator complement(2256439..2258160) Mycobacterium bovis BCG str. Pasteur 1173P2 4698869 YP_978137.1 CDS BCG_2047c NC_008769.1 2258221 2259060 R hypothetical protein complement(2258221..2259060) Mycobacterium bovis BCG str. Pasteur 1173P2 4695619 YP_978138.1 CDS pfkB NC_008769.1 2259057 2260076 R phosphofructokinase pfkB complement(2259057..2260076) Mycobacterium bovis BCG str. Pasteur 1173P2 4698037 YP_978139.1 CDS BCG_2049c NC_008769.1 2260093 2262138 R In Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG Pasteur, Rv2030c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv2030c into 2 parts, Mb2055c and Mb2056c; hypothetical protein complement(2260093..2262138) Mycobacterium bovis BCG str. Pasteur 1173P2 4698543 YP_978140.1 CDS hspX NC_008769.1 2262150 2262584 R heat shock protein hspX complement(2262150..2262584) Mycobacterium bovis BCG str. Pasteur 1173P2 4696845 YP_978141.1 CDS BCG_2051 NC_008769.1 2262781 2263776 D Differs from Rv2032 by 1aa, L318P; hypothetical protein 2262781..2263776 Mycobacterium bovis BCG str. Pasteur 1173P2 4696302 YP_978142.1 CDS BCG_2052c NC_008769.1 2263892 2264734 R hypothetical protein complement(2263892..2264734) Mycobacterium bovis BCG str. Pasteur 1173P2 4696373 YP_978143.1 CDS BCG_2053 NC_008769.1 2264946 2265269 D ArsR family transcriptional regulator 2264946..2265269 Mycobacterium bovis BCG str. Pasteur 1173P2 4696623 YP_978144.1 CDS BCG_2054 NC_008769.1 2265266 2265754 D hypothetical protein 2265266..2265754 Mycobacterium bovis BCG str. Pasteur 1173P2 4696875 YP_978145.1 CDS BCG_2055 NC_008769.1 2265751 2266392 D Differs from Rv2036 by 1aa, V93A due to 2bp substitution cc-tt; hypothetical protein 2265751..2266392 Mycobacterium bovis BCG str. Pasteur 1173P2 4697617 YP_978146.1 CDS BCG_2056c NC_008769.1 2266399 2267373 R Differs from Rv2037c by 1aa, Y312C; hypothetical protein complement(2266399..2267373) Mycobacterium bovis BCG str. Pasteur 1173P2 4696860 YP_978147.1 CDS BCG_2057c NC_008769.1 2267375 2268448 R sugar-transport ATP-binding protein ABC transporter complement(2267375..2268448) Mycobacterium bovis BCG str. Pasteur 1173P2 4697201 YP_978148.1 CDS BCG_2058c NC_008769.1 2268451 2269293 R Differs from Rv2039c by 1aa, F131V; sugar-transport integral membrane protein ABC transporter complement(2268451..2269293) Mycobacterium bovis BCG str. Pasteur 1173P2 4697679 YP_978149.1 CDS BCG_2059c NC_008769.1 2269280 2270182 R sugar-transport integral membrane protein ABC transporter complement(2269280..2270182) Mycobacterium bovis BCG str. Pasteur 1173P2 4695484 YP_978150.1 CDS BCG_2060c NC_008769.1 2270179 2271498 R Differs from Mb2067c by 1aa, A122V; sugar-binding lipoprotein complement(2270179..2271498) Mycobacterium bovis BCG str. Pasteur 1173P2 4696858 YP_978151.1 CDS BCG_2061c NC_008769.1 2271536 2272333 R hypothetical protein complement(2271536..2272333) Mycobacterium bovis BCG str. Pasteur 1173P2 4698044 YP_978152.1 CDS pncA NC_008769.1 2272333 2272893 R Differs from Rv2043c by 1aa, D57H; pyrazinamidase/nicotinamidas pncA complement(2272333..2272893) Mycobacterium bovis BCG str. Pasteur 1173P2 4695737 YP_978153.1 CDS BCG_2063c NC_008769.1 2272934 2273251 R hypothetical protein complement(2272934..2273251) Mycobacterium bovis BCG str. Pasteur 1173P2 4696815 YP_978154.1 CDS lipT NC_008769.1 2273337 2274872 R carboxylesterase LipT complement(2273337..2274872) Mycobacterium bovis BCG str. Pasteur 1173P2 4698638 YP_978155.1 CDS lppI NC_008769.1 2274921 2275577 D Differs from Rv2046 by 1aa, P17S; lipoprotein lppI 2274921..2275577 Mycobacterium bovis BCG str. Pasteur 1173P2 4696905 YP_978156.1 CDS BCG_2066c NC_008769.1 2275614 2278178 R hypothetical protein complement(2275614..2278178) Mycobacterium bovis BCG str. Pasteur 1173P2 4696498 YP_978157.1 CDS pks12 NC_008769.1 2278183 2290638 R Differs from Mb2074c and Rv2048c in several positions due to various substitutions, transitions and transversions; polyketide synthase complement(2278183..2290638) Mycobacterium bovis BCG str. Pasteur 1173P2 4697764 YP_978158.1 CDS BCG_2068c NC_008769.1 2290945 2291169 R hypothetical protein complement(2290945..2291169) Mycobacterium bovis BCG str. Pasteur 1173P2 4696192 YP_978159.1 CDS BCG_2069 NC_008769.1 2291473 2291808 D hypothetical protein 2291473..2291808 Mycobacterium bovis BCG str. Pasteur 1173P2 4696062 YP_978160.1 CDS ppm1 NC_008769.1 2291783 2294407 R polyprenol-monophosphomannose synthase Ppm1 complement(2291783..2294407) Mycobacterium bovis BCG str. Pasteur 1173P2 4696084 YP_978161.1 CDS BCG_2071c NC_008769.1 2294565 2296169 R hypothetical protein complement(2294565..2296169) Mycobacterium bovis BCG str. Pasteur 1173P2 4698103 YP_978162.1 CDS fxsA NC_008769.1 2296174 2296701 R F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein complement(2296174..2296701) Mycobacterium bovis BCG str. Pasteur 1173P2 4697837 YP_978163.1 CDS BCG_2073 NC_008769.1 2296777 2297490 D hypothetical protein 2296777..2297490 Mycobacterium bovis BCG str. Pasteur 1173P2 4696573 YP_978164.1 CDS rpsR2 NC_008769.1 2297739 2298005 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(2297739..2298005) Mycobacterium bovis BCG str. Pasteur 1173P2 4697123 YP_978165.1 CDS rpsN NC_008769.1 2298006 2298311 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 complement(2298006..2298311) Mycobacterium bovis BCG str. Pasteur 1173P2 4695808 YP_978166.1 CDS rpmG NC_008769.1 2298313 2298477 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(2298313..2298477) Mycobacterium bovis BCG str. Pasteur 1173P2 4698852 YP_978167.1 CDS rpmB NC_008769.1 2298477 2298713 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(2298477..2298713) Mycobacterium bovis BCG str. Pasteur 1173P2 4696787 YP_978168.1 CDS BCG_2078 NC_008769.1 2298826 2300361 D hypothetical protein 2298826..2300361 Mycobacterium bovis BCG str. Pasteur 1173P2 4697630 YP_978170.1 CDS BCG_2080c NC_008769.1 2300333 2300737 R hypothetical protein complement(2300333..2300737) Mycobacterium bovis BCG str. Pasteur 1173P2 4698440 YP_978171.1 CDS cobN NC_008769.1 2300821 2304405 R with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism; cobaltochelatase subunit CobN complement(2300821..2304405) Mycobacterium bovis BCG str. Pasteur 1173P2 4698254 YP_978172.1 CDS BCG_2082 NC_008769.1 2304483 2304716 D hypothetical protein 2304483..2304716 Mycobacterium bovis BCG str. Pasteur 1173P2 4699241 YP_978173.1 CDS cobG NC_008769.1 2305103 2306194 D cobalamin biosynthesis protein CobG 2305103..2306194 Mycobacterium bovis BCG str. Pasteur 1173P2 4697422 YP_978174.1 CDS cobH NC_008769.1 2306204 2306830 D catalyzes the interconversion of precorrin-8X and hydrogenobyrinate; precorrin-8X methylmutase 2306204..2306830 Mycobacterium bovis BCG str. Pasteur 1173P2 4697941 YP_978175.1 CDS cobI NC_008769.1 2306827 2308353 D bifunctional protein, CobI-CobJ fusion protein: S-adenosyl-L-methionine-precorrin-2 methyl transferase + precorrin-3 methylase 2306827..2308353 Mycobacterium bovis BCG str. Pasteur 1173P2 4698935 YP_978176.1 CDS BCG_2086c NC_008769.1 2308299 2309522 R hypothetical protein complement(2308299..2309522) Mycobacterium bovis BCG str. Pasteur 1173P2 4699079 YP_978177.1 CDS blaC NC_008769.1 2309538 2310461 R beta-lactamase complement(2309538..2310461) Mycobacterium bovis BCG str. Pasteur 1173P2 4696440 YP_978178.1 CDS sigC NC_008769.1 2310596 2311153 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigC 2310596..2311153 Mycobacterium bovis BCG str. Pasteur 1173P2 4696315 YP_978179.1 CDS cobK NC_008769.1 2311143 2311838 R CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; cobalt-precorrin-6x reductase complement(2311143..2311838) Mycobacterium bovis BCG str. Pasteur 1173P2 4695815 YP_978180.1 CDS cobM NC_008769.1 2311875 2312630 R Differs from Rv2071c by 1aa, M145I; precorrin-4 C11-methyltransferase CobM complement(2311875..2312630) Mycobacterium bovis BCG str. Pasteur 1173P2 4698684 YP_978181.1 CDS cobLb NC_008769.1 2312627 2313511 R In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a large 2029 bp deletion (H37Rv2.2330073-2332101-*)(RD9) leads to the loss of the NH2 part of cobL, the entire Rv2073 and Rv2074, and the COOH part of Mb2100c. In addition, while cobL exists as a single gene in Mycobacterium tuberculosis strain H37Rv, in Mycobacterium bovis a frameshift due to a single base insertion (*-t) splits cobL into 2 parts, cobLa and cobLb; precorrin-6y methyltransferase CobLb complement(2312627..2313511) Mycobacterium bovis BCG str. Pasteur 1173P2 4699302 YP_978182.1 CDS cobLa NC_008769.1 2313453 2313641 R In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a large deletion of 2029 bp (H37Rv2.2330073-2332101-*) (RD9) leads to the loss of the NH2 part of cobL, the entire Rv2073 and Rv2074, and the COOH part of Rv2075c. In addition, while cobL exists as a single gene in Mycobacterium tuberculosis strain H37Rv, in Mycobacterium bovis a frameshift due to a single base insertion (*-t) splits cobL into 2 parts, cobLa and cobLb; precorrin-6y methyltransferase CobLa complement(2313453..2313641) Mycobacterium bovis BCG str. Pasteur 1173P2 4699052 YP_978183.1 CDS BCG_2093c NC_008769.1 2313716 2314504 R In Mycobacterium bovis AF2122/97 and in Mycobacterium bovis BCG Pasteur, a large 2029 bp deletion (RD9) leads to the loss of the COOH part of Mb2100c, the entire Rv2074 and Rv2073, and the NH2 part of cobL compared to its homolog in Mycobacterium tuberculosis strain H37Rv; hypothetical protein complement(2313716..2314504) Mycobacterium bovis BCG str. Pasteur 1173P2 4699124 YP_978184.1 CDS BCG_2094c NC_008769.1 2314662 2314913 R hypothetical protein complement(2314662..2314913) Mycobacterium bovis BCG str. Pasteur 1173P2 4698660 YP_978185.1 CDS BCG_2095c NC_008769.1 2314948 2315919 R hypothetical protein complement(2314948..2315919) Mycobacterium bovis BCG str. Pasteur 1173P2 4697909 YP_978186.1 CDS BCG_2096c NC_008769.1 2315920 2316219 R hypothetical protein complement(2315920..2316219) Mycobacterium bovis BCG str. Pasteur 1173P2 4697488 YP_978187.1 CDS BCG_2097 NC_008769.1 2316684 2316998 D Differs from Rv2078 by 1aa, G6E; hypothetical protein 2316684..2316998 Mycobacterium bovis BCG str. Pasteur 1173P2 4697496 YP_978188.1 CDS BCG_2098 NC_008769.1 2316980 2318950 D Differs from Rv2079 by 2aa, C47Y, L216P; hypothetical protein 2316980..2318950 Mycobacterium bovis BCG str. Pasteur 1173P2 4697044 YP_978189.1 CDS lppJ NC_008769.1 2318931 2319494 D Differs from Rv2080 by 1aa, A23V; lipoprotein LppJ 2318931..2319494 Mycobacterium bovis BCG str. Pasteur 1173P2 4699298 YP_978190.1 CDS BCG_2100c NC_008769.1 2319530 2320141 R In Mycobacterium bovis, a 3 bp in-frame insertion (*-ggg) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (147 aa versus 146 aa). In Mycobacterium bovis BCG Pasteur, insertion of 11bp or 8bp compared to its homologs in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis leads to a product with a different C-terminal part; hypothetical protein complement(2319530..2320141) Mycobacterium bovis BCG str. Pasteur 1173P2 4698723 YP_978191.1 CDS BCG_2101 NC_008769.1 2320345 2322432 D Differs from Mb2108 (721 aa) and from Rv2082 (721 aa) by 26 codon in-frame deletion and from Rv2082 by 2aa, A183T, R612L; hypothetical protein 2320345..2322432 Mycobacterium bovis BCG str. Pasteur 1173P2 4697313 YP_978192.1 CDS BCG_2102 NC_008769.1 2322429 2323373 D Differs from Rv2083 by 1aa, V256L; hypothetical protein 2322429..2323373 Mycobacterium bovis BCG str. Pasteur 1173P2 4696438 YP_978193.1 CDS BCG_2103 NC_008769.1 2323366 2324361 D In Mycobacterium tuberculosis strain H37Rv, Rv2084 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to an 11 bp insertion (*-ggcgtacacac), splits Rv2084 into 2 parts; hypothetical protein 2323366..2324361 Mycobacterium bovis BCG str. Pasteur 1173P2 4696836 YP_978194.1 CDS BCG_2105 NC_008769.1 2324596 2324901 D hypothetical protein 2324596..2324901 Mycobacterium bovis BCG str. Pasteur 1173P2 4695413 YP_978195.1 CDS BCG_2106 NC_008769.1 2324880 2325485 D hypothetical protein 2324880..2325485 Mycobacterium bovis BCG str. Pasteur 1173P2 4698788 YP_978196.1 CDS BCG_2107 NC_008769.1 2325563 2325793 D hypothetical protein 2325563..2325793 Mycobacterium bovis BCG str. Pasteur 1173P2 4698008 YP_978197.1 CDS pknJ NC_008769.1 2325980 2327749 D transmembrane serine/threonine-protein kinase j pknJ 2325980..2327749 Mycobacterium bovis BCG str. Pasteur 1173P2 4697752 YP_978198.1 CDS pepE NC_008769.1 2327766 2328893 R dipeptidase PepE complement(2327766..2328893) Mycobacterium bovis BCG str. Pasteur 1173P2 4697525 YP_978199.1 CDS BCG_2110 NC_008769.1 2328942 2330009 D In Mycobacterium bovis BCG Pasteur, a 114 bp in-frame deletion leads to a shorter product compared to its ortholog in Mycobacterium tuberculosis strain H37Rv (355 aa versus 393 aa) and a 57 bp in-frame deletion leads to a shorter product compared to its ortholog in Mycobacterium bovis (355 aa versus 374 aa). Difference is due to copy number of tandem motif: DPTSGDPLHPAPPRLRSPL (or variant thereof) near N-terminus. Also differs from Rv2090 by 1aa, L320F; 5'-3' exonuclease 2328942..2330009 Mycobacterium bovis BCG str. Pasteur 1173P2 4696121 YP_978200.1 CDS BCG_2111c NC_008769.1 2330013 2330747 R hypothetical protein complement(2330013..2330747) Mycobacterium bovis BCG str. Pasteur 1173P2 4698874 YP_978201.1 CDS helY NC_008769.1 2330789 2333509 R Differs from Rv2092c by 1aa, M178T; ATP-dependent DNA helicase helY complement(2330789..2333509) Mycobacterium bovis BCG str. Pasteur 1173P2 4695437 YP_978202.1 CDS tatC NC_008769.1 2333558 2334484 R Sec-independent protein translocase transmembrane protein tatC complement(2333558..2334484) Mycobacterium bovis BCG str. Pasteur 1173P2 4695481 YP_978203.1 CDS tatA NC_008769.1 2334501 2334752 R TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase A complement(2334501..2334752) Mycobacterium bovis BCG str. Pasteur 1173P2 4697791 YP_978204.1 CDS BCG_2115c NC_008769.1 2334820 2335770 R Differs from Mb2122c by 1aa, A267V; hypothetical protein complement(2334820..2335770) Mycobacterium bovis BCG str. Pasteur 1173P2 4697789 YP_978205.1 CDS BCG_2116c NC_008769.1 2335767 2336765 R hypothetical protein complement(2335767..2336765) Mycobacterium bovis BCG str. Pasteur 1173P2 4698438 YP_978206.1 CDS BCG_2117c NC_008769.1 2336774 2338132 R hypothetical protein complement(2336774..2338132) Mycobacterium bovis BCG str. Pasteur 1173P2 4697360 YP_978207.1 CDS PE_PGRS36 NC_008769.1 2338184 2339659 R In Mycobacterium tuberculosis strain H37Rv, PE_PGRS36 and PE21 exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur,a single base insertion (*-c) leads to a single product more similar to PE_PGRS36. There is also a 3 bp in-frame deletion (ggc-*); PE-PGRS family protein complement(2338184..2339659) Mycobacterium bovis BCG str. Pasteur 1173P2 4698890 YP_978208.1 CDS BCG_2119 NC_008769.1 2339842 2341494 D hypothetical protein 2339842..2341494 Mycobacterium bovis BCG str. Pasteur 1173P2 4698706 YP_978209.1 CDS helZ NC_008769.1 2341693 2344734 D Differs from Rv2101 by 3aa, L462M, Q601P, S652A; helicase helZ 2341693..2344734 Mycobacterium bovis BCG str. Pasteur 1173P2 4698024 YP_978210.1 CDS BCG_2121 NC_008769.1 2344844 2345560 D hypothetical protein 2344844..2345560 Mycobacterium bovis BCG str. Pasteur 1173P2 4695482 YP_978211.1 CDS BCG_2122c NC_008769.1 2345539 2345973 R hypothetical protein complement(2345539..2345973) Mycobacterium bovis BCG str. Pasteur 1173P2 4698340 YP_978212.1 CDS BCG_2123c NC_008769.1 2345980 2346234 R hypothetical protein complement(2345980..2346234) Mycobacterium bovis BCG str. Pasteur 1173P2 4697431 YP_978213.1 CDS PE22 NC_008769.1 2347454 2347750 D PE family protein 2347454..2347750 Mycobacterium bovis BCG str. Pasteur 1173P2 4699051 YP_978214.1 CDS PPE36 NC_008769.1 2347806 2348537 D PPE family protein 2347806..2348537 Mycobacterium bovis BCG str. Pasteur 1173P2 4699378 YP_978215.1 CDS prcA NC_008769.1 2349077 2349823 R Differs from Rv2109c by 2aa, P135R, G182R; proteasome subunit alpha PrcA complement(2349077..2349823) Mycobacterium bovis BCG str. Pasteur 1173P2 4696451 YP_978216.1 CDS prcB NC_008769.1 2349820 2350695 R proteasome subunit beta PrcB complement(2349820..2350695) Mycobacterium bovis BCG str. Pasteur 1173P2 4696491 YP_978217.1 CDS BCG_2128c NC_008769.1 2350692 2350886 R hypothetical protein complement(2350692..2350886) Mycobacterium bovis BCG str. Pasteur 1173P2 4696492 YP_978218.1 CDS BCG_2129c NC_008769.1 2350999 2352606 R In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 57 bp in-frame deletion at the NH2 part, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (535 aa versus 554 aa); hypothetical protein complement(2350999..2352606) Mycobacterium bovis BCG str. Pasteur 1173P2 4696509 YP_978219.1 CDS BCG_2130 NC_008769.1 2352667 2353860 D Differs from Mb2137 by 1aa, S278L, and from Rv2113 by 1aa, P207T; integral membrane protein 2352667..2353860 Mycobacterium bovis BCG str. Pasteur 1173P2 4696379 YP_978220.1 CDS BCG_2131 NC_008769.1 2353871 2354494 D hypothetical protein 2353871..2354494 Mycobacterium bovis BCG str. Pasteur 1173P2 4698025 YP_978221.1 CDS BCG_2132c NC_008769.1 2354498 2356327 R ATPase complement(2354498..2356327) Mycobacterium bovis BCG str. Pasteur 1173P2 4698434 YP_978222.1 CDS lppK NC_008769.1 2356608 2357177 D lipoprotein lppK 2356608..2357177 Mycobacterium bovis BCG str. Pasteur 1173P2 4697758 YP_978223.1 CDS BCG_2134 NC_008769.1 2357185 2357478 D hypothetical protein 2357185..2357478 Mycobacterium bovis BCG str. Pasteur 1173P2 4698724 YP_978224.1 CDS BCG_2135c NC_008769.1 2357507 2358349 R RNA methyltransferase complement(2357507..2358349) Mycobacterium bovis BCG str. Pasteur 1173P2 4695596 YP_978225.1 CDS BCG_2136 NC_008769.1 2358423 2359259 D hypothetical protein 2358423..2359259 Mycobacterium bovis BCG str. Pasteur 1173P2 4699353 YP_978226.1 CDS BCG_2137c NC_008769.1 2359282 2359764 R integral membrane protein complement(2359282..2359764) Mycobacterium bovis BCG str. Pasteur 1173P2 4695844 YP_978227.1 CDS hisG NC_008769.1 2359843 2360697 R long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase complement(2359843..2360697) Mycobacterium bovis BCG str. Pasteur 1173P2 4699083 YP_978228.1 CDS hisE NC_008769.1 2360700 2360981 R catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase complement(2360700..2360981) Mycobacterium bovis BCG str. Pasteur 1173P2 4696067 YP_978229.1 CDS PPE37 NC_008769.1 2361108 2362502 D In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 27 bp in-frame deletion leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 473 aa); PPE family protein 2361108..2362502 Mycobacterium bovis BCG str. Pasteur 1173P2 4696065 YP_978230.1 CDS metH NC_008769.1 2362499 2366077 R Differs from Rv2124c by 1aa, V752I; 5-methyltetrahydrofolate--homocystein methyltransferase MetH complement(2362499..2366077) Mycobacterium bovis BCG str. Pasteur 1173P2 4696452 YP_978231.1 CDS BCG_2142 NC_008769.1 2366303 2367181 D Differs from Rv2125 by 1aa, S33G; hypothetical protein 2366303..2367181 Mycobacterium bovis BCG str. Pasteur 1173P2 4699103 YP_978232.1 CDS PE_PGRS37 NC_008769.1 2367212 2367982 R PE-PGRS family protein complement(2367212..2367982) Mycobacterium bovis BCG str. Pasteur 1173P2 4699072 YP_978233.1 CDS ansP1 NC_008769.1 2368626 2370095 D Differs from Rv2127 by 2aa, D9G, S44G; L-asparagine permease ansP1 2368626..2370095 Mycobacterium bovis BCG str. Pasteur 1173P2 4698707 YP_978234.1 CDS BCG_2145 NC_008769.1 2370095 2370298 D hypothetical protein 2370095..2370298 Mycobacterium bovis BCG str. Pasteur 1173P2 4695930 YP_978235.1 CDS BCG_2146c NC_008769.1 2370318 2371199 R short chain dehydrogenase complement(2370318..2371199) Mycobacterium bovis BCG str. Pasteur 1173P2 4698134 YP_978236.1 CDS cysS2 NC_008769.1 2371225 2372469 R catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase complement(2371225..2372469) Mycobacterium bovis BCG str. Pasteur 1173P2 4697992 YP_978237.1 CDS cysQ NC_008769.1 2372527 2373330 R hypothetical protein complement(2372527..2373330) Mycobacterium bovis BCG str. Pasteur 1173P2 4695542 YP_978238.1 CDS BCG_2149 NC_008769.1 2373421 2373651 D hypothetical protein 2373421..2373651 Mycobacterium bovis BCG str. Pasteur 1173P2 4695464 YP_978239.1 CDS BCG_2150c NC_008769.1 2373861 2374649 R hypothetical protein complement(2373861..2374649) Mycobacterium bovis BCG str. Pasteur 1173P2 4698114 YP_978240.1 CDS BCG_2151c NC_008769.1 2374660 2375247 R hypothetical protein complement(2374660..2375247) Mycobacterium bovis BCG str. Pasteur 1173P2 4699239 YP_978241.1 CDS BCG_2152c NC_008769.1 2375311 2376021 R hypothetical protein complement(2375311..2376021) Mycobacterium bovis BCG str. Pasteur 1173P2 4698126 YP_978242.1 CDS BCG_2153c NC_008769.1 2376018 2376848 R BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters UDP disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase complement(2376018..2376848) Mycobacterium bovis BCG str. Pasteur 1173P2 4699319 YP_978243.1 CDS BCG_2154c NC_008769.1 2376912 2377325 R hypothetical protein complement(2376912..2377325) Mycobacterium bovis BCG str. Pasteur 1173P2 4697084 YP_978244.1 CDS lppL NC_008769.1 2377340 2378416 D Differs from Mb2162 by 3aa, VQV348-350SRF, due to 7bp substitution in latter, tccaggt-gtccagg; lipoprotein LppL 2377340..2378416 Mycobacterium bovis BCG str. Pasteur 1173P2 4697689 YP_978245.1 CDS pyrD NC_008769.1 2378730 2379803 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 2378730..2379803 Mycobacterium bovis BCG str. Pasteur 1173P2 4698725 YP_978246.1 CDS TB18.6 NC_008769.1 2379808 2380338 R hypothetical protein complement(2379808..2380338) Mycobacterium bovis BCG str. Pasteur 1173P2 4696885 YP_978247.1 CDS BCG_2158c NC_008769.1 2380386 2381732 R hypothetical protein complement(2380386..2381732) Mycobacterium bovis BCG str. Pasteur 1173P2 4697562 YP_978248.1 CDS BCG_2159c NC_008769.1 2382203 2382520 R hypothetical protein complement(2382203..2382520) Mycobacterium bovis BCG str. Pasteur 1173P2 4696749 YP_978249.1 CDS BCG_2160 NC_008769.1 2382987 2384045 D hypothetical protein 2382987..2384045 Mycobacterium bovis BCG str. Pasteur 1173P2 4696732 YP_978250.1 CDS BCG_2161c NC_008769.1 2384175 2384531 R hypothetical protein complement(2384175..2384531) Mycobacterium bovis BCG str. Pasteur 1173P2 4696131 YP_978251.1 CDS wag31 NC_008769.1 2384626 2385408 R hypothetical protein complement(2384626..2385408) Mycobacterium bovis BCG str. Pasteur 1173P2 4696886 YP_978252.1 CDS BCG_2163c NC_008769.1 2385676 2385966 R hypothetical protein complement(2385676..2385966) Mycobacterium bovis BCG str. Pasteur 1173P2 4697890 YP_978253.1 CDS BCG_2164c NC_008769.1 2386128 2386853 R hypothetical protein complement(2386128..2386853) Mycobacterium bovis BCG str. Pasteur 1173P2 4698596 YP_978254.1 CDS BCG_2165c NC_008769.1 2386850 2387626 R hypothetical protein complement(2386850..2387626) Mycobacterium bovis BCG str. Pasteur 1173P2 4699048 YP_978255.1 CDS yfiH NC_008769.1 2387632 2388384 R hypothetical protein complement(2387632..2388384) Mycobacterium bovis BCG str. Pasteur 1173P2 4698585 YP_978256.1 CDS ftsZ NC_008769.1 2388395 2389534 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(2388395..2389534) Mycobacterium bovis BCG str. Pasteur 1173P2 4697799 YP_978257.1 CDS ftsQ NC_008769.1 2389707 2390651 R cell division protein ftsQ complement(2389707..2390651) Mycobacterium bovis BCG str. Pasteur 1173P2 4698535 YP_978258.1 CDS murC NC_008769.1 2390648 2392132 R Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase complement(2390648..2392132) Mycobacterium bovis BCG str. Pasteur 1173P2 4695824 YP_978259.1 CDS murG NC_008769.1 2392129 2393361 R UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDPdiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase complement(2392129..2393361) Mycobacterium bovis BCG str. Pasteur 1173P2 4698424 YP_978260.1 CDS ftsW NC_008769.1 2393358 2394932 R FtsW-like protein FtsW complement(2393358..2394932) Mycobacterium bovis BCG str. Pasteur 1173P2 4698427 YP_978261.1 CDS murD NC_008769.1 2394944 2396404 R UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase complement(2394944..2396404) Mycobacterium bovis BCG str. Pasteur 1173P2 4698532 YP_978262.1 CDS mraY NC_008769.1 2396406 2397485 R First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase complement(2396406..2397485) Mycobacterium bovis BCG str. Pasteur 1173P2 4698547 YP_978263.1 CDS murF NC_008769.1 2397482 2399014 R UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase MurF complement(2397482..2399014) Mycobacterium bovis BCG str. Pasteur 1173P2 4697970 YP_978264.1 CDS murE NC_008769.1 2399011 2400618 R involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase complement(2399011..2400618) Mycobacterium bovis BCG str. Pasteur 1173P2 4698426 YP_978265.1 CDS BCG_2176c NC_008769.1 2400641 2401675 R hypothetical protein complement(2400641..2401675) Mycobacterium bovis BCG str. Pasteur 1173P2 4698425 YP_978266.1 CDS BCG_2177c NC_008769.1 2401672 2402292 R In Mycobacterium tuberculosis strain H37Rv, Rv2160A and Rv2160c exist as 2 genes with an overlap region between them. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a 4 bp insertion (*-ggaa) leads to a single product; hypothetical protein complement(2401672..2402292) Mycobacterium bovis BCG str. Pasteur 1173P2 4698299 YP_978267.1 CDS BCG_2178c NC_008769.1 2402285 2403151 R hypothetical protein complement(2402285..2403151) Mycobacterium bovis BCG str. Pasteur 1173P2 4695649 YP_978268.1 CDS PE_PGRS38 NC_008769.1 2403254 2404726 R In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, in-frame deletions of 108 bp and 18 bp leads to a shorter product than in Mycobacterium tuberculosis strain H37Rv (490 aa versus 532 aa); PE-PGRS family protein complement(2403254..2404726) Mycobacterium bovis BCG str. Pasteur 1173P2 4698464 YP_978269.1 CDS pbpB NC_008769.1 2404936 2406975 R penicillin-binding membrane protein pbpB complement(2404936..2406975) Mycobacterium bovis BCG str. Pasteur 1173P2 4698708 YP_978270.1 CDS BCG_2181c NC_008769.1 2406972 2408126 R Differs from Mb2188c by 1aa, V202A; proline rich membrane protein complement(2406972..2408126) Mycobacterium bovis BCG str. Pasteur 1173P2 4698834 YP_978271.1 CDS mraW NC_008769.1 2408123 2409313 R S-adenosyl-methyltransferase complement(2408123..2409313) Mycobacterium bovis BCG str. Pasteur 1173P2 4696183 YP_978272.1 CDS BCG_2183c NC_008769.1 2409315 2409746 R MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ complement(2409315..2409746) Mycobacterium bovis BCG str. Pasteur 1173P2 4696788 YP_978273.1 CDS BCG_2184c NC_008769.1 2410095 2410499 R hypothetical protein complement(2410095..2410499) Mycobacterium bovis BCG str. Pasteur 1173P2 4696671 YP_978274.1 CDS BCG_2185 NC_008769.1 2410765 2411385 D hypothetical protein 2410765..2411385 Mycobacterium bovis BCG str. Pasteur 1173P2 4698174 YP_978275.1 CDS lppM NC_008769.1 2411481 2412164 D lipoprotein lppM 2411481..2412164 Mycobacterium bovis BCG str. Pasteur 1173P2 4697733 YP_978276.1 CDS BCG_2187c NC_008769.1 2412161 2413066 R hypothetical protein complement(2412161..2413066) Mycobacterium bovis BCG str. Pasteur 1173P2 4698726 YP_978277.1 CDS idsA2 NC_008769.1 2413377 2414435 D geranylgeranyl pyrophosphate synthetase idsA2 2413377..2414435 Mycobacterium bovis BCG str. Pasteur 1173P2 4697575 YP_978278.1 CDS BCG_2189 NC_008769.1 2414439 2416142 D Differs from Rv2174 and Mb2196 at 3'-end owing to frameshift due to 1 bp insertion (t) at position corresponding to H37Rv coordinates 2437401-2437402, and from Rv2174 by 1aa, S451A.; hypothetical protein 2414439..2416142 Mycobacterium bovis BCG str. Pasteur 1173P2 4696222 YP_978279.1 CDS BCG_2190c NC_008769.1 2415977 2416417 R Differs from Rv2175c by 1aa, L17P; regulatory protein complement(2415977..2416417) Mycobacterium bovis BCG str. Pasteur 1173P2 4698255 YP_978280.1 CDS pknL NC_008769.1 2416472 2417671 D Differs from Rv2176 by 1aa, A52S; transmembrane serine/threonine-protein kinase L pknL 2416472..2417671 Mycobacterium bovis BCG str. Pasteur 1173P2 4698488 YP_978281.1 CDS BCG_2192c NC_008769.1 2417813 2418478 R Differs from Rv2177c by 1aa, K115T; transposase complement(2417813..2418478) Mycobacterium bovis BCG str. Pasteur 1173P2 4696188 YP_978282.1 CDS aroG NC_008769.1 2418863 2420251 R Differs from Rv2178c by 1aa, E265D; 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase complement(2418863..2420251) Mycobacterium bovis BCG str. Pasteur 1173P2 4698650 YP_978283.1 CDS BCG_2194c NC_008769.1 2420342 2420848 R hypothetical protein complement(2420342..2420848) Mycobacterium bovis BCG str. Pasteur 1173P2 4695761 YP_978284.1 CDS BCG_2195c NC_008769.1 2420858 2421745 R Differs from Rv2180c by 1aa, T156P; integral membrane protein complement(2420858..2421745) Mycobacterium bovis BCG str. Pasteur 1173P2 4699065 YP_978285.1 CDS BCG_2196 NC_008769.1 2421833 2423116 D integral membrane protein 2421833..2423116 Mycobacterium bovis BCG str. Pasteur 1173P2 4696677 YP_978286.1 CDS BCG_2197c NC_008769.1 2423117 2423860 R 1-acylglycerol-3-phosphate O-acyltransferase complement(2423117..2423860) Mycobacterium bovis BCG str. Pasteur 1173P2 4698317 YP_978287.1 CDS BCG_2198c NC_008769.1 2423946 2424341 R hypothetical protein complement(2423946..2424341) Mycobacterium bovis BCG str. Pasteur 1173P2 4699145 YP_978288.1 CDS BCG_2199c NC_008769.1 2424338 2425477 R hypothetical protein complement(2424338..2425477) Mycobacterium bovis BCG str. Pasteur 1173P2 4695760 YP_978289.1 CDS TB16.3 NC_008769.1 2425597 2426031 R hypothetical protein complement(2425597..2426031) Mycobacterium bovis BCG str. Pasteur 1173P2 4698798 YP_978290.1 CDS BCG_2201c NC_008769.1 2426136 2426525 R hypothetical protein complement(2426136..2426525) Mycobacterium bovis BCG str. Pasteur 1173P2 4697560 YP_978291.1 CDS BCG_2202 NC_008769.1 2426691 2427203 D In Mycobacterium tuberculosis strain H37Rv, fadD15 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to single base deletion (t-*) splits fadD15 into 2 parts; hypothetical protein 2426691..2427203 Mycobacterium bovis BCG str. Pasteur 1173P2 4696867 YP_978292.1 CDS fadD15 NC_008769.1 2426966 2428492 D In Mycobacterium tuberculosis strain H37Rv, fadD15 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to single base deletion (t-*) splits fadD15 into 2 parts. Differs from Rv2187 by 2aa, I8T, E287G; long-chain-fatty-acid-CoA ligase fadD15 2426966..2428492 Mycobacterium bovis BCG str. Pasteur 1173P2 4699321 YP_978293.1 CDS BCG_2204c NC_008769.1 2428523 2429680 R hypothetical protein complement(2428523..2429680) Mycobacterium bovis BCG str. Pasteur 1173P2 4698016 YP_978294.1 CDS BCG_2205c NC_008769.1 2429777 2430550 R hypothetical protein complement(2429777..2430550) Mycobacterium bovis BCG str. Pasteur 1173P2 4698620 YP_978295.1 CDS BCG_2206c NC_008769.1 2430645 2431802 R hypothetical protein complement(2430645..2431802) Mycobacterium bovis BCG str. Pasteur 1173P2 4696133 YP_978296.1 CDS BCG_2207 NC_008769.1 2432349 2434286 D contains 3'-5'exonuclease domain; hypothetical protein 2432349..2434286 Mycobacterium bovis BCG str. Pasteur 1173P2 4696738 YP_978297.1 CDS trpD NC_008769.1 2434161 2435273 R Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase complement(2434161..2435273) Mycobacterium bovis BCG str. Pasteur 1173P2 4698953 YP_978298.1 CDS ctaE NC_008769.1 2435431 2436042 D cytochrome C oxidase (subunit III) ctaE 2435431..2436042 Mycobacterium bovis BCG str. Pasteur 1173P2 4696872 YP_978299.1 CDS qcrC NC_008769.1 2436083 2436925 D ubiquinol-cytochrome C reductase QcrC (cytochrome C subunit) 2436083..2436925 Mycobacterium bovis BCG str. Pasteur 1173P2 4697651 YP_978300.1 CDS qcrA NC_008769.1 2436922 2438211 D Differs from Rv2195 by 1aa, I281M; Rieske iron-sulfur protein QcrA 2436922..2438211 Mycobacterium bovis BCG str. Pasteur 1173P2 4695434 YP_978301.1 CDS qcrB NC_008769.1 2438208 2439857 D ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) 2438208..2439857 Mycobacterium bovis BCG str. Pasteur 1173P2 4695432 YP_978302.1 CDS BCG_2213c NC_008769.1 2440148 2440792 R Differs from Rv2197c by 1aa, S202A; hypothetical protein complement(2440148..2440792) Mycobacterium bovis BCG str. Pasteur 1173P2 4695433 YP_978303.1 CDS mmpS3 NC_008769.1 2440792 2441691 R membrane protein mmpS3 complement(2440792..2441691) Mycobacterium bovis BCG str. Pasteur 1173P2 4697774 YP_978304.1 CDS BCG_2215c NC_008769.1 2441877 2442296 R hypothetical protein complement(2441877..2442296) Mycobacterium bovis BCG str. Pasteur 1173P2 4697492 YP_978305.1 CDS ctaC NC_008769.1 2442304 2443395 R transmembrane cytochrome C oxidase (subunit II) ctaC complement(2442304..2443395) Mycobacterium bovis BCG str. Pasteur 1173P2 4698871 YP_978306.1 CDS asnB NC_008769.1 2443641 2445599 D asparagine synthetase AsnB 2443641..2445599 Mycobacterium bovis BCG str. Pasteur 1173P2 4697753 YP_978307.1 CDS adoK NC_008769.1 2445697 2446671 R adenosine kinase complement(2445697..2446671) Mycobacterium bovis BCG str. Pasteur 1173P2 4696535 YP_978308.1 CDS BCG_2219 NC_008769.1 2446875 2447567 D hypothetical protein 2446875..2447567 Mycobacterium bovis BCG str. Pasteur 1173P2 4695687 YP_978309.1 CDS BCG_2220c NC_008769.1 2447575 2447931 R hypothetical protein complement(2447575..2447931) Mycobacterium bovis BCG str. Pasteur 1173P2 4696110 YP_978310.1 CDS BCG_2221c NC_008769.1 2448031 2449107 R hypothetical protein complement(2448031..2449107) Mycobacterium bovis BCG str. Pasteur 1173P2 4698166 YP_978311.1 CDS BCG_2222 NC_008769.1 2449266 2449976 D hypothetical protein 2449266..2449976 Mycobacterium bovis BCG str. Pasteur 1173P2 4698597 YP_978312.1 CDS cobT NC_008769.1 2450055 2451140 D catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2450055..2451140 Mycobacterium bovis BCG str. Pasteur 1173P2 4698703 YP_978313.1 CDS cobS NC_008769.1 2451137 2451886 D catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 2451137..2451886 Mycobacterium bovis BCG str. Pasteur 1173P2 4697942 YP_978314.1 CDS BCG_2225 NC_008769.1 2452044 2453582 D integral membrane protein 2452044..2453582 Mycobacterium bovis BCG str. Pasteur 1173P2 4697928 YP_978315.1 CDS ilvE NC_008769.1 2453508 2454614 R catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase complement(2453508..2454614) Mycobacterium bovis BCG str. Pasteur 1173P2 4696760 YP_978316.1 CDS gcvT NC_008769.1 2454686 2455825 R catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T complement(2454686..2455825) Mycobacterium bovis BCG str. Pasteur 1173P2 4699342 YP_978317.1 CDS BCG_2228 NC_008769.1 2455834 2456970 D hypothetical protein 2455834..2456970 Mycobacterium bovis BCG str. Pasteur 1173P2 4698645 YP_978318.1 CDS pepB NC_008769.1 2456982 2458529 D catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 2456982..2458529 Mycobacterium bovis BCG str. Pasteur 1173P2 4699189 YP_978319.1 CDS ephD NC_008769.1 2458567 2460345 R short chain dehydrogenase complement(2458567..2460345) Mycobacterium bovis BCG str. Pasteur 1173P2 4696119 YP_978320.1 CDS dlaT NC_008769.1 2460609 2462270 D Differs from Rv2215 and Mb2238 by 1aa, V517L; dihydrolipoamide acetyltransferase 2460609..2462270 Mycobacterium bovis BCG str. Pasteur 1173P2 4698294 YP_978321.1 CDS BCG_2232 NC_008769.1 2462270 2463175 D hypothetical protein 2462270..2463175 Mycobacterium bovis BCG str. Pasteur 1173P2 4696602 YP_978322.1 CDS lipB NC_008769.1 2463228 2463920 D lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 2463228..2463920 Mycobacterium bovis BCG str. Pasteur 1173P2 4698303 YP_978323.1 CDS lipA NC_008769.1 2463917 2464852 D catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 2463917..2464852 Mycobacterium bovis BCG str. Pasteur 1173P2 4698687 YP_978324.1 CDS BCG_2235 NC_008769.1 2464879 2465631 D Differs from Rv2219 by 1aa, L74F; hypothetical protein 2464879..2465631 Mycobacterium bovis BCG str. Pasteur 1173P2 4698686 YP_978325.1 CDS BCG_2236c NC_008769.1 2465638 2466060 R hypothetical protein complement(2465638..2466060) Mycobacterium bovis BCG str. Pasteur 1173P2 4697428 YP_978326.1 CDS glnA1 NC_008769.1 2466259 2467695 D glutamine synthetase glnA1 2466259..2467695 Mycobacterium bovis BCG str. Pasteur 1173P2 4698818 YP_978327.1 CDS glnE NC_008769.1 2468013 2470997 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(2468013..2470997) Mycobacterium bovis BCG str. Pasteur 1173P2 4696209 YP_978328.1 CDS glnA2 NC_008769.1 2471046 2472386 R glutamine synthetase glnA2 complement(2471046..2472386) Mycobacterium bovis BCG str. Pasteur 1173P2 4697946 YP_978329.1 CDS BCG_2240c NC_008769.1 2472481 2474043 R Differs from Rv2223c and Mb2247c by 1aa, S307A; protease complement(2472481..2474043) Mycobacterium bovis BCG str. Pasteur 1173P2 4696210 YP_978330.1 CDS BCG_2241c NC_008769.1 2474105 2475667 R protease complement(2474105..2475667) Mycobacterium bovis BCG str. Pasteur 1173P2 4699161 YP_978331.1 CDS panB NC_008769.1 2476386 2477231 D catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 2476386..2477231 Mycobacterium bovis BCG str. Pasteur 1173P2 4699049 YP_978332.1 CDS BCG_2243 NC_008769.1 2477476 2479017 D Differs from Rv2226 and Mb2250 by 1aa, N299D and G31D, respectively; hypothetical protein 2477476..2479017 Mycobacterium bovis BCG str. Pasteur 1173P2 4695407 YP_978333.1 CDS BCG_2244 NC_008769.1 2479575 2479895 D In Mycobacterium tuberculosis strain H37Rv, Rv2227 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 1 bp to 2 bp substitution (t-cc) splits Rv2227 in two parts; hypothetical protein 2479575..2479895 Mycobacterium bovis BCG str. Pasteur 1173P2 4698574 YP_978334.1 CDS BCG_2245 NC_008769.1 2479903 2480277 D In Mycobacterium tuberculosis strain H37Rv, Rv2227 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 1 bp to 2 bp substitution (t-cc) splits Rv2227 in two parts; hypothetical protein 2479903..2480277 Mycobacterium bovis BCG str. Pasteur 1173P2 4695992 YP_978335.1 CDS BCG_2246c NC_008769.1 2480289 2481383 R bifunctional RNase H/acid phosphatase complement(2480289..2481383) Mycobacterium bovis BCG str. Pasteur 1173P2 4697138 YP_978336.1 CDS BCG_2247c NC_008769.1 2481380 2482117 R Differs from Rv2229c by 1aa, Q239R; hypothetical protein complement(2481380..2482117) Mycobacterium bovis BCG str. Pasteur 1173P2 4697424 YP_978337.1 CDS BCG_2248c NC_008769.1 2482114 2483253 R hypothetical protein complement(2482114..2483253) Mycobacterium bovis BCG str. Pasteur 1173P2 4696829 YP_978338.1 CDS cobC NC_008769.1 2483250 2484344 R hypothetical protein complement(2483250..2484344) Mycobacterium bovis BCG str. Pasteur 1173P2 4695857 YP_978339.1 CDS BCG_2250 NC_008769.1 2484923 2485798 D hypothetical protein 2484923..2485798 Mycobacterium bovis BCG str. Pasteur 1173P2 4698830 YP_978340.1 CDS ptpA NC_008769.1 2485791 2486282 D phosphotyrosine protein phosphatase ptpA 2485791..2486282 Mycobacterium bovis BCG str. Pasteur 1173P2 4697319 YP_978341.1 CDS BCG_2252 NC_008769.1 2486282 2487097 D hypothetical protein 2486282..2487097 Mycobacterium bovis BCG str. Pasteur 1173P2 4697318 YP_978342.1 CDS cobD NC_008769.1 2487079 2488020 R CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group; cobalamin biosynthesis protein complement(2487079..2488020) Mycobacterium bovis BCG str. Pasteur 1173P2 4696413 YP_978343.1 CDS BCG_2254 NC_008769.1 2488134 2488901 D hypothetical protein 2488134..2488901 Mycobacterium bovis BCG str. Pasteur 1173P2 4698693 YP_978344.1 CDS ahpE NC_008769.1 2489360 2489821 R peroxiredoxin AhpE complement(2489360..2489821) Mycobacterium bovis BCG str. Pasteur 1173P2 4696868 YP_978345.1 CDS BCG_2256c NC_008769.1 2489821 2490297 R hypothetical protein complement(2489821..2490297) Mycobacterium bovis BCG str. Pasteur 1173P2 4696994 YP_978346.1 CDS BCG_2257c NC_008769.1 2490335 2491132 R Differs from Rv2240c by 1aa, K259T; hypothetical protein complement(2490335..2491132) Mycobacterium bovis BCG str. Pasteur 1173P2 4695877 YP_978347.1 CDS aceE NC_008769.1 2491184 2493889 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 2491184..2493889 Mycobacterium bovis BCG str. Pasteur 1173P2 4697781 YP_978348.1 CDS BCG_2259 NC_008769.1 2493949 2495193 D Differs from Rv2242 and Mb2266 by 1aa, T363A; hypothetical protein 2493949..2495193 Mycobacterium bovis BCG str. Pasteur 1173P2 4698981 YP_978349.1 CDS fabD NC_008769.1 2495432 2496340 D malonyl CoA-ACP transacylase 2495432..2496340 Mycobacterium bovis BCG str. Pasteur 1173P2 4697871 YP_978350.1 CDS acpP NC_008769.1 2496416 2496763 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 2496416..2496763 Mycobacterium bovis BCG str. Pasteur 1173P2 4698122 YP_978351.1 CDS kasA NC_008769.1 2496760 2498010 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 2496760..2498010 Mycobacterium bovis BCG str. Pasteur 1173P2 4696908 YP_978352.1 CDS kasB NC_008769.1 2498041 2499357 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 2498041..2499357 Mycobacterium bovis BCG str. Pasteur 1173P2 4697349 YP_978353.1 CDS accD6 NC_008769.1 2499388 2500809 D acetyl/propionyl CoA carboxylase subunit beta 2499388..2500809 Mycobacterium bovis BCG str. Pasteur 1173P2 4697350 YP_978354.1 CDS BCG_2265 NC_008769.1 2500917 2501321 D In Mycobacterium bovis and Mycobacterium tuberculosis, Rv2248 and Mb2272 exist as single gene. In Mycobacterium bovis BCG Pasteur, the ortholog is split into two parts owing to single base insertion in G-string (-g) at position equivalent to Mycobacterium tuberculosis position 2522481-2522482; hypothetical protein 2500917..2501321 Mycobacterium bovis BCG str. Pasteur 1173P2 4698892 YP_978355.1 CDS BCG_2266 NC_008769.1 2501029 2501733 D In Mycobacterium bovis and Mycobacterium tuberculosis, Rv2248 and Mb2272 exist as single gene. In Mycobacterium bovis BCG Pasteur, the ortholog is split into two parts owing to single base insertion in G-string (-g) at position equivalent to Mycobacterium tuberculosis position 2522481-2522482; hypothetical protein 2501029..2501733 Mycobacterium bovis BCG str. Pasteur 1173P2 4696414 YP_978356.1 CDS glpD1 NC_008769.1 2501802 2503352 R glycerol-3-phosphate dehydrogenase glpd1 complement(2501802..2503352) Mycobacterium bovis BCG str. Pasteur 1173P2 4697353 YP_978357.1 CDS BCG_2268c NC_008769.1 2503346 2503915 R Differs from Mb2274c by 1aa, D68A; transcriptional regulatory protein complement(2503346..2503915) Mycobacterium bovis BCG str. Pasteur 1173P2 4697768 YP_978358.1 CDS BCG_2269 NC_008769.1 2503963 2505552 D In Mycobacterium tuberculosis H37Rv, Rv2250A and Rv2251 exist as 2 genes with an overlap region between them. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base deletion (g-*) leads to a single product; flavoprotein 2503963..2505552 Mycobacterium bovis BCG str. Pasteur 1173P2 4696843 YP_978359.1 CDS BCG_2270 NC_008769.1 2505549 2506478 D involved in the biosynthesis of phosphatidylinositol mannosides (PIMs); the enzyme from Mycobacterium tuberculosis can phosphorylate a variety of amphipathic lipids; diacylglycerol kinase 2505549..2506478 Mycobacterium bovis BCG str. Pasteur 1173P2 4697305 YP_978360.1 CDS BCG_2271 NC_008769.1 2506544 2507047 D hypothetical protein 2506544..2507047 Mycobacterium bovis BCG str. Pasteur 1173P2 4697420 YP_978361.1 CDS BCG_2272c NC_008769.1 2507080 2507535 R Differs from Rv2254c by 1aa, V68A; hypothetical protein complement(2507080..2507535) Mycobacterium bovis BCG str. Pasteur 1173P2 4695918 YP_978362.1 CDS BCG_2273c NC_008769.1 2507540 2507734 R hypothetical protein complement(2507540..2507734) Mycobacterium bovis BCG str. Pasteur 1173P2 4697311 YP_978363.1 CDS BCG_2274c NC_008769.1 2507901 2508434 R Differs from Rv2256c by 1aa, G26A; hypothetical protein complement(2507901..2508434) Mycobacterium bovis BCG str. Pasteur 1173P2 4695753 YP_978364.1 CDS BCG_2275c NC_008769.1 2508564 2509382 R hypothetical protein complement(2508564..2509382) Mycobacterium bovis BCG str. Pasteur 1173P2 4696442 YP_978365.1 CDS BCG_2276c NC_008769.1 2509396 2510457 R transcriptional regulatory protein complement(2509396..2510457) Mycobacterium bovis BCG str. Pasteur 1173P2 4695850 YP_978366.1 CDS adhE2 NC_008769.1 2510699 2511784 D zinc-dependent alcohol dehydrogenase AdhE2 2510699..2511784 Mycobacterium bovis BCG str. Pasteur 1173P2 4695899 YP_978367.1 CDS BCG_2278 NC_008769.1 2511784 2512419 D hypothetical protein 2511784..2512419 Mycobacterium bovis BCG str. Pasteur 1173P2 4697167 YP_978368.1 CDS BCG_2279c NC_008769.1 2512496 2514004 R In Mycobacterium tuberculosis strain H37Rv, Rv2262c and Rv2261c exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 2 bp deletion (ct-*) results in a single product; hypothetical protein complement(2512496..2514004) Mycobacterium bovis BCG str. Pasteur 1173P2 4696839 YP_978369.1 CDS BCG_2280 NC_008769.1 2514093 2515046 D short chain dehydrogenase 2514093..2515046 Mycobacterium bovis BCG str. Pasteur 1173P2 4696555 YP_978370.1 CDS BCG_2281c NC_008769.1 2515024 2516802 R hypothetical protein complement(2515024..2516802) Mycobacterium bovis BCG str. Pasteur 1173P2 4696334 YP_978371.1 CDS BCG_2282 NC_008769.1 2517152 2518381 D hypothetical protein 2517152..2518381 Mycobacterium bovis BCG str. Pasteur 1173P2 4696428 YP_978372.1 CDS cyp124 NC_008769.1 2518556 2519842 D cytochrome P450 124 CYP124 2518556..2519842 Mycobacterium bovis BCG str. Pasteur 1173P2 4695374 YP_978373.1 CDS BCG_2284c NC_008769.1 2520096 2521262 R hypothetical protein complement(2520096..2521262) Mycobacterium bovis BCG str. Pasteur 1173P2 4696355 YP_978374.1 CDS cyp128 NC_008769.1 2521259 2522728 R Differs from Rv2268c and Mb2291c by 1aa, F203L; cytochrome P450 128 cyp128 complement(2521259..2522728) Mycobacterium bovis BCG str. Pasteur 1173P2 4697817 YP_978375.1 CDS BCG_2286c NC_008769.1 2522741 2523073 R hypothetical protein complement(2522741..2523073) Mycobacterium bovis BCG str. Pasteur 1173P2 4696664 YP_978376.1 CDS lppN NC_008769.1 2523150 2523677 D Differs from Mb2293 by 1aa, P152L; lipoprotein lppN 2523150..2523677 Mycobacterium bovis BCG str. Pasteur 1173P2 4697304 YP_978377.1 CDS BCG_2288 NC_008769.1 2523784 2524083 D hypothetical protein 2523784..2524083 Mycobacterium bovis BCG str. Pasteur 1173P2 4698727 YP_978378.1 CDS BCG_2289 NC_008769.1 2524189 2524557 D hypothetical protein 2524189..2524557 Mycobacterium bovis BCG str. Pasteur 1173P2 4697007 YP_978379.1 CDS BCG_2290 NC_008769.1 2524554 2524883 D hypothetical protein 2524554..2524883 Mycobacterium bovis BCG str. Pasteur 1173P2 4695938 YP_978380.1 CDS BCG_2291c NC_008769.1 2524940 2525257 R Differs from Rv2274c by 1aa, M33I; hypothetical protein complement(2524940..2525257) Mycobacterium bovis BCG str. Pasteur 1173P2 4695367 YP_978381.1 CDS BCG_2292 NC_008769.1 2525335 2526204 D Differs from Rv2275 and Mb2298 by 1aa, A261E; hypothetical protein 2525335..2526204 Mycobacterium bovis BCG str. Pasteur 1173P2 4696639 YP_978382.1 CDS cyp121 NC_008769.1 2526201 2527391 D cytochrome P450 121 CYP121 2526201..2527391 Mycobacterium bovis BCG str. Pasteur 1173P2 4699163 YP_978383.1 CDS BCG_2294c NC_008769.1 2527576 2528475 R In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 1358 bp deletion containing an IS6110 sequence, disrupts the 5' start of Rv2277c resulting in a slightly shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (299 aa versus 301 aa). Differs from Mb2300c by 1aa; glycerolphosphodiesterase complement(2527576..2528475) Mycobacterium bovis BCG str. Pasteur 1173P2 4697119 YP_978384.1 CDS BCG_2295 NC_008769.1 2528654 2530033 D dehydrogenase 2528654..2530033 Mycobacterium bovis BCG str. Pasteur 1173P2 4698568 YP_978385.1 CDS pitB NC_008769.1 2530267 2531925 D phosphate-transport permease PitB 2530267..2531925 Mycobacterium bovis BCG str. Pasteur 1173P2 4697662 YP_978386.1 CDS BCG_2297c NC_008769.1 2532032 2532970 R LysR family transcriptional regulator complement(2532032..2532970) Mycobacterium bovis BCG str. Pasteur 1173P2 4699307 YP_978387.1 CDS BCG_2298 NC_008769.1 2533035 2533229 D hypothetical protein 2533035..2533229 Mycobacterium bovis BCG str. Pasteur 1173P2 4699037 YP_978388.1 CDS lipM NC_008769.1 2533239 2534534 D esterase LipM 2533239..2534534 Mycobacterium bovis BCG str. Pasteur 1173P2 4695474 YP_978389.1 CDS BCG_2300 NC_008769.1 2534567 2535904 D hypothetical protein 2534567..2535904 Mycobacterium bovis BCG str. Pasteur 1173P2 4698634 YP_978390.1 CDS BCG_2301c NC_008769.1 2535971 2536234 R In Mycobacterium tuberculosis strain H37Rv, Rv2286c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, an in-frame stop codon due to a single base transition (c-t) splits Rv2286c into 2 parts; hypothetical protein complement(2535971..2536234) Mycobacterium bovis BCG str. Pasteur 1173P2 4696078 YP_978391.1 CDS BCG_2302c NC_008769.1 2536262 2536663 R In Mycobacterium tuberculosis strain H37Rv, Rv2286c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base transition (c-t) splits Rv2286c into 2 parts; hypothetical protein complement(2536262..2536663) Mycobacterium bovis BCG str. Pasteur 1173P2 4698040 YP_978392.1 CDS yjcE NC_008769.1 2536797 2538425 D integral membrane transport protein YjcE 2536797..2538425 Mycobacterium bovis BCG str. Pasteur 1173P2 4696053 YP_978393.1 CDS BCG_2304 NC_008769.1 2538422 2538799 D hypothetical protein 2538422..2538799 Mycobacterium bovis BCG str. Pasteur 1173P2 4697800 YP_978394.1 CDS cdh NC_008769.1 2538769 2539551 D CDP-diacylglycerol pyrophosphatase 2538769..2539551 Mycobacterium bovis BCG str. Pasteur 1173P2 4695834 YP_978395.1 CDS lppOa NC_008769.1 2539693 2539848 D In Mycobacterium tuberculosis strain H37Rv, Rv2290 exists as a single gene. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (c-*), splits lppO into 2 parts, lppOa and lppOb; lipoprotein lppOa 2539693..2539848 Mycobacterium bovis BCG str. Pasteur 1173P2 4696063 YP_978396.1 CDS lppOb NC_008769.1 2539842 2540207 D In Mycobacterium tuberculosis strain H37Rv, Rv2290 exists as a single gene. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (c-*), splits lppO into 2 parts, lppOa and lppOb; lipoprotein lppOb 2539842..2540207 Mycobacterium bovis BCG str. Pasteur 1173P2 4695919 YP_978397.1 CDS sseB NC_008769.1 2540267 2541121 D In Mycobacterium bovis, truncation at the 5' start due to a 2 bp deletion (tg-*), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG Pasteur (256 aa versus 284 aa). Differs from Rv2291 by 1aa, A262E; thiosulfate sulfurtransferase SseB 2540267..2541121 Mycobacterium bovis BCG str. Pasteur 1173P2 4695920 YP_978398.1 CDS BCG_2309c NC_008769.1 2541122 2542126 R In Mycobacterium tuberculosis strain H37Rv, Rv2293c and Rv2292c exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base insertion (*-g) results in a single product; hypothetical protein complement(2541122..2542126) Mycobacterium bovis BCG str. Pasteur 1173P2 4696754 YP_978399.1 CDS BCG_2310 NC_008769.1 2542421 2543644 D aminotransferase 2542421..2543644 Mycobacterium bovis BCG str. Pasteur 1173P2 4696185 YP_978400.1 CDS BCG_2311 NC_008769.1 2543867 2544505 D hypothetical protein 2543867..2544505 Mycobacterium bovis BCG str. Pasteur 1173P2 4697185 YP_978401.1 CDS BCG_2312 NC_008769.1 2544599 2545501 D haloalkane dehalogenase 2544599..2545501 Mycobacterium bovis BCG str. Pasteur 1173P2 4697631 YP_978402.1 CDS BCG_2313 NC_008769.1 2545533 2545985 D hypothetical protein 2545533..2545985 Mycobacterium bovis BCG str. Pasteur 1173P2 4698133 YP_978403.1 CDS BCG_2314 NC_008769.1 2546177 2547148 D hypothetical protein 2546177..2547148 Mycobacterium bovis BCG str. Pasteur 1173P2 4696790 YP_978404.1 CDS htpG NC_008769.1 2547154 2549097 R molecular chaperone; heat shock protein 90 complement(2547154..2549097) Mycobacterium bovis BCG str. Pasteur 1173P2 4696718 YP_978405.1 CDS BCG_2316c NC_008769.1 2549171 2550103 R hypothetical protein complement(2549171..2550103) Mycobacterium bovis BCG str. Pasteur 1173P2 4696303 YP_978406.1 CDS cut2 NC_008769.1 2550110 2550802 D cutinase cut2 2550110..2550802 Mycobacterium bovis BCG str. Pasteur 1173P2 4697109 YP_978407.1 CDS BCG_2318 NC_008769.1 2550908 2551150 D hypothetical protein 2550908..2551150 Mycobacterium bovis BCG str. Pasteur 1173P2 4696589 YP_978408.1 CDS BCG_2319c NC_008769.1 2551191 2552114 R antibiotic-resistance protein complement(2551191..2552114) Mycobacterium bovis BCG str. Pasteur 1173P2 4696667 YP_978409.1 CDS BCG_2320c NC_008769.1 2552111 2552320 R hypothetical protein complement(2552111..2552320) Mycobacterium bovis BCG str. Pasteur 1173P2 4698152 YP_978410.1 CDS BCG_2321 NC_008769.1 2552904 2554193 D Differs from Rv2305 by 1aa, D148G; hypothetical protein 2552904..2554193 Mycobacterium bovis BCG str. Pasteur 1173P2 4696728 YP_978411.1 CDS BCG_2322 NC_008769.1 2554203 2554796 D Differs from Rv2306A by 1aa, V47I; hypothetical protein 2554203..2554796 Mycobacterium bovis BCG str. Pasteur 1173P2 4696393 YP_978412.1 CDS BCG_2323 NC_008769.1 2554583 2555017 D hypothetical protein 2554583..2555017 Mycobacterium bovis BCG str. Pasteur 1173P2 4696506 YP_978413.1 CDS BCG_2324c NC_008769.1 2554946 2555791 R Differs from Mb2330c by 2aa, T25M, W235R; hypothetical protein complement(2554946..2555791) Mycobacterium bovis BCG str. Pasteur 1173P2 4697465 YP_978414.1 CDS BCG_2325c NC_008769.1 2556323 2556514 R hypothetical protein complement(2556323..2556514) Mycobacterium bovis BCG str. Pasteur 1173P2 4697620 YP_978415.1 CDS BCG_2326c NC_008769.1 2556599 2557030 R hypothetical protein complement(2556599..2557030) Mycobacterium bovis BCG str. Pasteur 1173P2 4696397 YP_978416.1 CDS BCG_2327c NC_008769.1 2557123 2557305 R hypothetical protein complement(2557123..2557305) Mycobacterium bovis BCG str. Pasteur 1173P2 4697135 YP_978417.1 CDS BCG_2328 NC_008769.1 2557514 2558230 D Differs from Rv2308 by 1aa, V43G; hypothetical protein 2557514..2558230 Mycobacterium bovis BCG str. Pasteur 1173P2 4699115 YP_978418.1 CDS BCG_2329c NC_008769.1 2558938 2559393 R integrase complement(2558938..2559393) Mycobacterium bovis BCG str. Pasteur 1173P2 4697286 YP_978419.1 CDS BCG_2330 NC_008769.1 2560140 2560427 D Differs from Rv2309A by 1aa, K53E; hypothetical protein 2560140..2560427 Mycobacterium bovis BCG str. Pasteur 1173P2 4696346 YP_978420.1 CDS BCG_2331 NC_008769.1 2560530 2560874 D excisionase 2560530..2560874 Mycobacterium bovis BCG str. Pasteur 1173P2 4697288 YP_978421.1 CDS BCG_2332 NC_008769.1 2560979 2561503 D hypothetical protein 2560979..2561503 Mycobacterium bovis BCG str. Pasteur 1173P2 4695461 YP_978422.1 CDS BCG_2333 NC_008769.1 2561581 2561850 D hypothetical protein 2561581..2561850 Mycobacterium bovis BCG str. Pasteur 1173P2 4696900 YP_978423.1 CDS BCG_2334c NC_008769.1 2562147 2563001 R hypothetical protein complement(2562147..2563001) Mycobacterium bovis BCG str. Pasteur 1173P2 4695492 YP_978424.1 CDS BCG_2335c NC_008769.1 2563012 2564385 R hypothetical protein complement(2563012..2564385) Mycobacterium bovis BCG str. Pasteur 1173P2 4697993 YP_978425.1 CDS BCG_2336c NC_008769.1 2564382 2565899 R hypothetical protein complement(2564382..2565899) Mycobacterium bovis BCG str. Pasteur 1173P2 4695762 YP_978426.1 CDS uspA NC_008769.1 2565933 2566805 D Differs from Rv2316 by 1aa, L126V; sugar-transport integral membrane protein ABC transporter uspA 2565933..2566805 Mycobacterium bovis BCG str. Pasteur 1173P2 4696361 YP_978427.1 CDS uspB NC_008769.1 2566792 2567616 D sugar-transport integral membrane protein ABC transporter uspB 2566792..2567616 Mycobacterium bovis BCG str. Pasteur 1173P2 4697746 YP_978428.1 CDS uspC NC_008769.1 2567613 2568935 D Differs from Rv2318 by 1aa, V354L; periplasmic sugar-binding lipoprotein uspC 2567613..2568935 Mycobacterium bovis BCG str. Pasteur 1173P2 4697747 YP_978429.1 CDS BCG_2340c NC_008769.1 2568943 2569821 R Differs from Rv2319c and Mb2346c by 1aa, G105E; hypothetical protein complement(2568943..2569821) Mycobacterium bovis BCG str. Pasteur 1173P2 4697748 YP_978430.1 CDS rocE NC_008769.1 2569818 2571248 R cationic amino acid transport integral membrane protein rocE complement(2569818..2571248) Mycobacterium bovis BCG str. Pasteur 1173P2 4697357 YP_978431.1 CDS rocD2 NC_008769.1 2571249 2571794 R ornithine aminotransferase (C-terminus part) rocD2 complement(2571249..2571794) Mycobacterium bovis BCG str. Pasteur 1173P2 4696322 YP_978432.1 CDS rocD1 NC_008769.1 2571794 2572459 R ornithine aminotransferase (N-terminus part) rocD1 complement(2571794..2572459) Mycobacterium bovis BCG str. Pasteur 1173P2 4696321 YP_978433.1 CDS BCG_2344c NC_008769.1 2572456 2573364 R Differs from Rv2323c by 1aa, T113A; hypothetical protein complement(2572456..2573364) Mycobacterium bovis BCG str. Pasteur 1173P2 4696320 YP_978434.1 CDS BCG_2345 NC_008769.1 2573429 2573875 D AsnC family transcriptional regulator 2573429..2573875 Mycobacterium bovis BCG str. Pasteur 1173P2 4696998 YP_978435.1 CDS BCG_2346c NC_008769.1 2574104 2574952 R hypothetical protein complement(2574104..2574952) Mycobacterium bovis BCG str. Pasteur 1173P2 4698047 YP_978436.1 CDS BCG_2347c NC_008769.1 2574949 2577042 R transmembrane ABC transporter ATP-binding protein complement(2574949..2577042) Mycobacterium bovis BCG str. Pasteur 1173P2 4698014 YP_978437.1 CDS BCG_2348 NC_008769.1 2577083 2577574 D hypothetical protein 2577083..2577574 Mycobacterium bovis BCG str. Pasteur 1173P2 4699326 YP_978438.1 CDS PE23 NC_008769.1 2577826 2578974 D PE family protein 2577826..2578974 Mycobacterium bovis BCG str. Pasteur 1173P2 4699351 YP_978439.1 CDS narK1 NC_008769.1 2579009 2580556 R nitrite extrusion protein 1 narK1 complement(2579009..2580556) Mycobacterium bovis BCG str. Pasteur 1173P2 4699379 YP_978440.1 CDS lppP NC_008769.1 2580790 2581317 R Differs from Rv2330c and Mb2357c by 1aa, A97S; lipoprotein lppP complement(2580790..2581317) Mycobacterium bovis BCG str. Pasteur 1173P2 4697118 YP_978441.1 CDS BCG_2352 NC_008769.1 2581392 2581778 D hypothetical protein 2581392..2581778 Mycobacterium bovis BCG str. Pasteur 1173P2 4695921 YP_978442.1 CDS BCG_2353 NC_008769.1 2581835 2582173 D Differs from Rv2331A by 1aa, L46I; hypothetical protein 2581835..2582173 Mycobacterium bovis BCG str. Pasteur 1173P2 4699290 YP_978443.1 CDS mez NC_008769.1 2582203 2583849 D malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 2582203..2583849 Mycobacterium bovis BCG str. Pasteur 1173P2 4695430 YP_978444.1 CDS BCG_2355c NC_008769.1 2583846 2585417 R In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, single base insertion (*-g) leads to a slightly longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (523 aa versus 537 aa). Also differs from Rv2333c by 2aa, Y69D, Q503H; integral membrane transport protein complement(2583846..2585417) Mycobacterium bovis BCG str. Pasteur 1173P2 4699107 YP_978445.1 CDS cysK1 NC_008769.1 2585892 2586824 D cysteine synthase A cysK1 2585892..2586824 Mycobacterium bovis BCG str. Pasteur 1173P2 4696646 YP_978446.1 CDS BCG_2357 NC_008769.1 2586828 2587517 D serine acetyltransferase cysE 2586828..2587517 Mycobacterium bovis BCG str. Pasteur 1173P2 4695614 YP_978447.1 CDS BCG_2358 NC_008769.1 2587933 2588901 D hypothetical protein 2587933..2588901 Mycobacterium bovis BCG str. Pasteur 1173P2 4695528 YP_978448.1 CDS BCG_2359c NC_008769.1 2588965 2590083 R Differs from Rv2337c by 1aa, V119G; hypothetical protein complement(2588965..2590083) Mycobacterium bovis BCG str. Pasteur 1173P2 4698525 YP_978449.1 CDS moeW NC_008769.1 2590203 2591159 R hypothetical protein complement(2590203..2591159) Mycobacterium bovis BCG str. Pasteur 1173P2 4696715 YP_978450.1 CDS mmpL9a NC_008769.1 2591790 2594270 D In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base transition (g-a) splits mmpL9 into 2 parts, mmpL9a and mmpL9b; transmembrane transport protein mmpL9a 2591790..2594270 Mycobacterium bovis BCG str. Pasteur 1173P2 4697174 YP_978451.1 CDS mmpL9b NC_008769.1 2594283 2594678 D In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) splits mmpL9 into 2 parts, mmpL9a and mmpL9b; transmembrane transport protein mmpL9b 2594283..2594678 Mycobacterium bovis BCG str. Pasteur 1173P2 4696175 YP_978452.1 CDS PE_PGRS39 NC_008769.1 2594764 2596005 R Differs from Rv2340c and Mb2369c by 1aa, T222D; PE-PGRS family protein complement(2594764..2596005) Mycobacterium bovis BCG str. Pasteur 1173P2 4697489 YP_978453.1 CDS lppQ NC_008769.1 2596694 2597113 D lipoprotein lppQ 2596694..2597113 Mycobacterium bovis BCG str. Pasteur 1173P2 4697861 YP_978454.1 CDS BCG_2365 NC_008769.1 2597369 2597626 D hypothetical protein 2597369..2597626 Mycobacterium bovis BCG str. Pasteur 1173P2 4695922 YP_978455.1 CDS dnaG NC_008769.1 2597630 2599549 R synthesizes RNA primers at the replication forks; DNA primase complement(2597630..2599549) Mycobacterium bovis BCG str. Pasteur 1173P2 4698564 YP_978456.1 CDS dgt NC_008769.1 2599554 2600849 R dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein complement(2599554..2600849) Mycobacterium bovis BCG str. Pasteur 1173P2 4697835 YP_978457.1 CDS BCG_2368 NC_008769.1 2600918 2602900 D hypothetical protein 2600918..2602900 Mycobacterium bovis BCG str. Pasteur 1173P2 4695556 YP_978458.1 CDS esxO NC_008769.1 2602985 2603167 R In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a large 8963 bp deletion (RD5) leads to the loss of the NH2 part of Rv2346c, and the 9 following CDSs up to Rv2356 including the 3 phospolipases C enzymes plcC, plcB and plcA, compared to the homolog in Mycobacterium tuberculosis H37Rv; ESAT-6 like protein 6 complement(2602985..2603167) Mycobacterium bovis BCG str. Pasteur 1173P2 4696214 YP_978459.1 CDS PPE71 NC_008769.1 2603151 2604557 R Compared to Mycobacterium bovis, there has been a 2579bp bp deletion at position equivalent to M. bovis 2604493-2607071, this has resulted in an in-frame fusion of the 5'-end of PPE40 with the 3'-end of PPE71 probably due to a homologous recombination event between codons 68 and 174 of PPE40 as the PPE40 and PPE71 genes have identical 5'-ends (first 535 bp). Differs from Mb2376c (PPE71) by extra 11aa, insertion of A at position 68 due to 3bp insertion (present in PPE40) and STNVGSGNIG at position 307 due to 30 bp insertion. M. bovis BCG Pasteur thus has three copies of tandem repeat STNVGSGNIG compared to two in Mb2376c. The 3'-end of PPE71 of M. bovis BCG Pasteur has also been truncated as a result of the same deletion described in In Mycobacterium bovis, 8963 bp deletion (RD5); PPE family protein complement(2603151..2604557) Mycobacterium bovis BCG str. Pasteur 1173P2 4698827 YP_978460.1 CDS glyS NC_008769.1 2604695 2606086 R Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase complement(2604695..2606086) Mycobacterium bovis BCG str. Pasteur 1173P2 4696416 YP_978461.1 CDS BCG_2372 NC_008769.1 2606268 2606675 D ArsR family transcriptional regulator 2606268..2606675 Mycobacterium bovis BCG str. Pasteur 1173P2 4697848 YP_978462.1 CDS furB NC_008769.1 2606672 2607064 D Differs from Rv2359 by 1aa, R64H; ferric uptake regulation protein furB 2606672..2607064 Mycobacterium bovis BCG str. Pasteur 1173P2 4695438 YP_978463.1 CDS BCG_2374c NC_008769.1 2607172 2607600 R Differs from Rv2360c by 1aa, T66A; hypothetical protein complement(2607172..2607600) Mycobacterium bovis BCG str. Pasteur 1173P2 4695505 YP_978464.1 CDS BCG_2375c NC_008769.1 2607600 2608490 R catalyzes the formation of UDP pyrophosphate from isopentenyl pyrophosphate; UDP pyrophosphate synthase complement(2607600..2608490) Mycobacterium bovis BCG str. Pasteur 1173P2 4697692 YP_978465.1 CDS recO NC_008769.1 2608483 2609280 R involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO complement(2608483..2609280) Mycobacterium bovis BCG str. Pasteur 1173P2 4698079 YP_978466.1 CDS amiA2 NC_008769.1 2609342 2610796 D catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 2609342..2610796 Mycobacterium bovis BCG str. Pasteur 1173P2 4695691 YP_978467.1 CDS era NC_008769.1 2610793 2611695 R Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era complement(2610793..2611695) Mycobacterium bovis BCG str. Pasteur 1173P2 4696631 YP_978468.1 CDS BCG_2379c NC_008769.1 2611769 2612110 R hypothetical protein complement(2611769..2612110) Mycobacterium bovis BCG str. Pasteur 1173P2 4697857 YP_978469.1 CDS BCG_2380c NC_008769.1 2612082 2613389 R hypothetical protein complement(2612082..2613389) Mycobacterium bovis BCG str. Pasteur 1173P2 4696483 YP_978470.1 CDS BCG_2381c NC_008769.1 2613386 2613934 R metalloprotease complement(2613386..2613934) Mycobacterium bovis BCG str. Pasteur 1173P2 4698110 YP_978471.1 CDS phoH1 NC_008769.1 2613938 2614996 R phoH-like protein phoH1 complement(2613938..2614996) Mycobacterium bovis BCG str. Pasteur 1173P2 4695580 YP_978472.1 CDS BCG_2383c NC_008769.1 2614968 2615270 R hypothetical protein complement(2614968..2615270) Mycobacterium bovis BCG str. Pasteur 1173P2 4697585 YP_978473.1 CDS BCG_2384c NC_008769.1 2615267 2616580 R hypothetical protein complement(2615267..2616580) Mycobacterium bovis BCG str. Pasteur 1173P2 4697255 YP_978474.1 CDS PE_PGRS40 NC_008769.1 2616775 2616960 D PE-PGRS family protein 2616775..2616960 Mycobacterium bovis BCG str. Pasteur 1173P2 4695454 YP_978475.1 CDS BCG_2386c NC_008769.1 2617059 2617847 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(2617059..2617847) Mycobacterium bovis BCG str. Pasteur 1173P2 4697096 YP_978476.1 CDS dnaJ2 NC_008769.1 2617861 2619009 R chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ complement(2617861..2619009) Mycobacterium bovis BCG str. Pasteur 1173P2 4697691 YP_978477.1 CDS hrcA NC_008769.1 2619084 2620115 R Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor complement(2619084..2620115) Mycobacterium bovis BCG str. Pasteur 1173P2 4697210 YP_978478.1 CDS BCG_2389 NC_008769.1 2620287 2620604 D hypothetical protein 2620287..2620604 Mycobacterium bovis BCG str. Pasteur 1173P2 4697335 YP_978479.1 CDS cfp2 NC_008769.1 2620631 2621137 R low molecular weight antigen cfp2 complement(2620631..2621137) Mycobacterium bovis BCG str. Pasteur 1173P2 4697997 YP_978480.1 CDS mbtH NC_008769.1 2621237 2621452 R Differs from Rv2377c by 1aa, A69V; protein mbtH complement(2621237..2621452) Mycobacterium bovis BCG str. Pasteur 1173P2 4698223 YP_978481.1 CDS mbtG NC_008769.1 2621430 2622725 R lysine-N-oxygenase mbtG complement(2621430..2622725) Mycobacterium bovis BCG str. Pasteur 1173P2 4695347 YP_978482.1 CDS mbtF NC_008769.1 2622722 2627107 R Differs from Rv2379c by 1aa, D589E; peptide synthetase mbtF complement(2622722..2627107) Mycobacterium bovis BCG str. Pasteur 1173P2 4695792 YP_978483.1 CDS mbtE NC_008769.1 2627089 2632137 R peptide synthetase mbtE complement(2627089..2632137) Mycobacterium bovis BCG str. Pasteur 1173P2 4695791 YP_978484.1 CDS mbtD NC_008769.1 2632277 2635291 R polyketide synthase complement(2632277..2635291) Mycobacterium bovis BCG str. Pasteur 1173P2 4695790 YP_978485.1 CDS mbtC NC_008769.1 2635291 2636625 R polyketide synthase complement(2635291..2636625) Mycobacterium bovis BCG str. Pasteur 1173P2 4695789 YP_978486.1 CDS mbtB NC_008769.1 2636615 2640859 R Differs from Rv2383c by 2aa, Q264R, P1253T, and from Mb2404c by 1aa, P1253T; phenyloxazoline synthase mbtB complement(2636615..2640859) Mycobacterium bovis BCG str. Pasteur 1173P2 4695788 YP_978487.1 CDS mbtA NC_008769.1 2640958 2642655 D bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase 2640958..2642655 Mycobacterium bovis BCG str. Pasteur 1173P2 4698665 YP_978488.1 CDS mbtJ NC_008769.1 2642751 2643671 D acetyl hydrolase mbtJ 2642751..2643671 Mycobacterium bovis BCG str. Pasteur 1173P2 4698664 YP_978489.1 CDS mbtI NC_008769.1 2643675 2645027 R catalyzes conversion of chorismate to salicylate, in mycobactin siderophore construction; requires Mg(2+) for function; salicylate synthase MbtI complement(2643675..2645027) Mycobacterium bovis BCG str. Pasteur 1173P2 4695349 YP_978490.1 CDS BCG_2401 NC_008769.1 2645787 2647040 D hypothetical protein 2645787..2647040 Mycobacterium bovis BCG str. Pasteur 1173P2 4695348 YP_978491.1 CDS hemN NC_008769.1 2647037 2648164 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(2647037..2648164) Mycobacterium bovis BCG str. Pasteur 1173P2 4696556 YP_978492.1 CDS rpfD NC_008769.1 2648270 2648734 R resuscitation-promoting factor rpfD complement(2648270..2648734) Mycobacterium bovis BCG str. Pasteur 1173P2 4698930 YP_978493.1 CDS BCG_2404c NC_008769.1 2648731 2649288 R Differs from Mb2411c by 1aa, I33T; hypothetical protein complement(2648731..2649288) Mycobacterium bovis BCG str. Pasteur 1173P2 4699110 YP_978494.1 CDS nirA NC_008769.1 2649701 2651392 D ferredoxin-dependent nitrite reductase NirA 2649701..2651392 Mycobacterium bovis BCG str. Pasteur 1173P2 4699039 YP_978495.1 CDS cysH NC_008769.1 2651389 2652153 D catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 2651389..2652153 Mycobacterium bovis BCG str. Pasteur 1173P2 4699205 YP_978496.1 CDS BCG_2407 NC_008769.1 2652150 2653049 D In Mycobacterium bovis BCG Pasteur, duplication of 54 bp segment after codon 3 leads to additional 18 aa and two tandem copies of motif PATMQSAAMLRSGAIEAP, compared to its ortholog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis AF2122/97; hypothetical protein 2652150..2653049 Mycobacterium bovis BCG str. Pasteur 1173P2 4696089 YP_978497.1 CDS ggtB NC_008769.1 2653086 2655017 D Differs from Rv2394 by 1aa Q396R; gamma-glutamyltranspeptidase precursor ggtB 2653086..2655017 Mycobacterium bovis BCG str. Pasteur 1173P2 4696147 YP_978498.1 CDS BCG_2409 NC_008769.1 2655148 2655588 D In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis BCG Pasteur, as in Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits Rv2395 into 2 parts. The frameshift occurs after the 44th codon; integral membrane protein 2655148..2655588 Mycobacterium bovis BCG str. Pasteur 1173P2 4698648 YP_978499.1 CDS BCG_2410 NC_008769.1 2655602 2657152 D In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits Rv2395 into 2 parts. BCG_2410 also differs from Rv2395 by 1aa, P396S; integral membrane protein 2655602..2657152 Mycobacterium bovis BCG str. Pasteur 1173P2 4696229 YP_978500.1 CDS PE_PGRS41 NC_008769.1 2657876 2658958 D Identical to Mb2418 of Mycobacterium bovis, including 3 bp deletion (gcc-*) that leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (360 aa versus 361 aa) due to deletion of A95. Also differs from Rv2396 by 2aa, N26S, S324N; PE-PGRS family protein 2657876..2658958 Mycobacterium bovis BCG str. Pasteur 1173P2 4698075 YP_978501.1 CDS cysA1 NC_008769.1 2658983 2660038 R sulfate-transport ATP-binding protein ABC transporter cysA1 complement(2658983..2660038) Mycobacterium bovis BCG str. Pasteur 1173P2 4697097 YP_978502.1 CDS cysW NC_008769.1 2660055 2660873 R Differs from Rv2398c by 1aa, A141G, and from Mb2420c by 1aa, R264H; sulfate-transport integral membrane protein ABC transporter cysW complement(2660055..2660873) Mycobacterium bovis BCG str. Pasteur 1173P2 4698202 YP_978503.1 CDS cysT NC_008769.1 2660870 2661721 R sulfate-transport integral membrane protein ABC transporter cysT complement(2660870..2661721) Mycobacterium bovis BCG str. Pasteur 1173P2 4699054 YP_978504.1 CDS subI NC_008769.1 2661718 2662788 R sulfate-binding lipoprotein subI complement(2661718..2662788) Mycobacterium bovis BCG str. Pasteur 1173P2 4696907 YP_978505.1 CDS BCG_2416 NC_008769.1 2662802 2663131 D hypothetical protein 2662802..2663131 Mycobacterium bovis BCG str. Pasteur 1173P2 4696757 YP_978506.1 CDS BCG_2417c NC_008769.1 2663116 2663319 R hypothetical protein complement(2663116..2663319) Mycobacterium bovis BCG str. Pasteur 1173P2 4698121 YP_978507.1 CDS BCG_2418 NC_008769.1 2663603 2665531 D hypothetical protein 2663603..2665531 Mycobacterium bovis BCG str. Pasteur 1173P2 4697387 YP_978508.1 CDS lppR NC_008769.1 2665609 2666364 R Differs from Rv2403c by 1aa, L127V; lipoprotein lppR complement(2665609..2666364) Mycobacterium bovis BCG str. Pasteur 1173P2 4697245 YP_978509.1 CDS lepA NC_008769.1 2666361 2668322 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(2666361..2668322) Mycobacterium bovis BCG str. Pasteur 1173P2 4695923 YP_978510.1 CDS BCG_2421 NC_008769.1 2668343 2668912 D hypothetical protein 2668343..2668912 Mycobacterium bovis BCG str. Pasteur 1173P2 4695956 YP_978511.1 CDS BCG_2422c NC_008769.1 2669083 2669511 R hypothetical protein complement(2669083..2669511) Mycobacterium bovis BCG str. Pasteur 1173P2 4698587 YP_978512.1 CDS BCG_2423 NC_008769.1 2669771 2670613 D member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2669771..2670613 Mycobacterium bovis BCG str. Pasteur 1173P2 4698347 YP_978513.1 CDS PE24 NC_008769.1 2671206 2671925 D PE family-like protein 2671206..2671925 Mycobacterium bovis BCG str. Pasteur 1173P2 4698138 YP_978514.1 CDS BCG_2425c NC_008769.1 2671683 2672522 R hypothetical protein complement(2671683..2672522) Mycobacterium bovis BCG str. Pasteur 1173P2 4699380 YP_978515.1 CDS BCG_2426c NC_008769.1 2672522 2673499 R hypothetical protein complement(2672522..2673499) Mycobacterium bovis BCG str. Pasteur 1173P2 4699330 YP_978516.1 CDS BCG_2427c NC_008769.1 2673499 2675154 R hypothetical protein complement(2673499..2675154) Mycobacterium bovis BCG str. Pasteur 1173P2 4698107 YP_978517.1 CDS rpsT NC_008769.1 2675264 2675524 D binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 2675264..2675524 Mycobacterium bovis BCG str. Pasteur 1173P2 4696622 YP_978518.1 CDS BCG_2429c NC_008769.1 2675540 2676490 R hypothetical protein complement(2675540..2676490) Mycobacterium bovis BCG str. Pasteur 1173P2 4697804 YP_978519.1 CDS BCG_2430c NC_008769.1 2676521 2678065 R In Mycobacterium bovis, a single base insertion (*-t) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv and in Mycobacterium bovis BCG Pasteur (523 aa versus 514 aa); hypothetical protein complement(2676521..2678065) Mycobacterium bovis BCG str. Pasteur 1173P2 4698900 YP_978520.1 CDS BCG_2431c NC_008769.1 2678080 2678973 R Differs from Rv2415c by 1aa, L291R; hypothetical protein complement(2678080..2678973) Mycobacterium bovis BCG str. Pasteur 1173P2 4698350 YP_978521.1 CDS BCG_2432c NC_008769.1 2679313 2680539 R Differs from Mb2439c by 1aa, T76A; hypothetical protein complement(2679313..2680539) Mycobacterium bovis BCG str. Pasteur 1173P2 4695660 YP_978522.1 CDS BCG_2433c NC_008769.1 2680661 2681503 R hypothetical protein complement(2680661..2681503) Mycobacterium bovis BCG str. Pasteur 1173P2 4695868 YP_978523.1 CDS BCG_2434c NC_008769.1 2681584 2682327 R hypothetical protein complement(2681584..2682327) Mycobacterium bovis BCG str. Pasteur 1173P2 4698531 YP_978524.1 CDS BCG_2435c NC_008769.1 2682317 2682988 R Differs from Mb2442c by 1aa, A165V; phosphoglycerate mutase complement(2682317..2682988) Mycobacterium bovis BCG str. Pasteur 1173P2 4697021 YP_978525.1 CDS BCG_2436c NC_008769.1 2682985 2683368 R Differs from Rv2420c and Mb2443c by insertion of 1aa, Pro, at position 126 due to 3bp insertion (gcg) at position equivalent to Mycobacterium bovis 2685985-2685986; hypothetical protein complement(2682985..2683368) Mycobacterium bovis BCG str. Pasteur 1173P2 4697110 YP_978526.1 CDS nadD NC_008769.1 2683365 2684000 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(2683365..2684000) Mycobacterium bovis BCG str. Pasteur 1173P2 4696761 YP_978527.1 CDS BCG_2438 NC_008769.1 2684275 2684547 D hypothetical protein 2684275..2684547 Mycobacterium bovis BCG str. Pasteur 1173P2 4696614 YP_978528.1 CDS BCG_2439 NC_008769.1 2684789 2685835 D hypothetical protein 2684789..2685835 Mycobacterium bovis BCG str. Pasteur 1173P2 4699293 YP_978529.1 CDS BCG_2440c NC_008769.1 2685968 2686660 R In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 2 bp deletion (gt-*) splits Rv2424c into 2 parts. Differs from Rv2424c by 3aa, I172T, A173T and Y192H; transposase complement(2685968..2686660) Mycobacterium bovis BCG str. Pasteur 1173P2 4698469 YP_978530.1 CDS BCG_2441c NC_008769.1 2686674 2686967 R In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 2 bp deletion (gt-*) splits Rv2424c into 2 parts; transposase complement(2686674..2686967) Mycobacterium bovis BCG str. Pasteur 1173P2 4696381 YP_978531.1 CDS BCG_2442c NC_008769.1 2687056 2688498 R hypothetical protein complement(2687056..2688498) Mycobacterium bovis BCG str. Pasteur 1173P2 4696265 YP_978532.1 CDS BCG_2443c NC_008769.1 2688498 2689373 R Differs from Rv2426c by 1aa, L113F; hypothetical protein complement(2688498..2689373) Mycobacterium bovis BCG str. Pasteur 1173P2 4698415 YP_978533.1 CDS proA NC_008769.1 2689400 2690647 R Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase complement(2689400..2690647) Mycobacterium bovis BCG str. Pasteur 1173P2 4696716 YP_978534.1 CDS ahpC NC_008769.1 2691363 2691950 D alkyl hydroperoxide reductase 2691363..2691950 Mycobacterium bovis BCG str. Pasteur 1173P2 4695523 YP_978535.1 CDS ahpD NC_008769.1 2691976 2692509 D alkyl hydroperoxide reductase 2691976..2692509 Mycobacterium bovis BCG str. Pasteur 1173P2 4695782 YP_978536.1 CDS PPE41 NC_008769.1 2692506 2693090 R PPE family protein complement(2692506..2693090) Mycobacterium bovis BCG str. Pasteur 1173P2 4697590 YP_978537.1 CDS PE25 NC_008769.1 2693137 2693436 R PE family protein complement(2693137..2693436) Mycobacterium bovis BCG str. Pasteur 1173P2 4697819 YP_978538.1 CDS BCG_2451c NC_008769.1 2693607 2694017 R hypothetical protein complement(2693607..2694017) Mycobacterium bovis BCG str. Pasteur 1173P2 4697125 YP_978539.1 CDS BCG_2452c NC_008769.1 2694014 2694304 R hypothetical protein complement(2694014..2694304) Mycobacterium bovis BCG str. Pasteur 1173P2 4695895 YP_978540.1 CDS BCG_2453c NC_008769.1 2694285 2695730 R hypothetical protein complement(2694285..2695730) Mycobacterium bovis BCG str. Pasteur 1173P2 4697122 YP_978541.1 CDS BCG_2454c NC_008769.1 2695727 2697919 R cyclase complement(2695727..2697919) Mycobacterium bovis BCG str. Pasteur 1173P2 4695527 YP_978542.1 CDS rbsK NC_008769.1 2698400 2699314 D Differs from Rv2436 by 2aa, V274A, A282V; ribokinase rbsK 2698400..2699314 Mycobacterium bovis BCG str. Pasteur 1173P2 4698465 YP_978543.1 CDS BCG_2456 NC_008769.1 2699546 2699965 D hypothetical protein 2699546..2699965 Mycobacterium bovis BCG str. Pasteur 1173P2 4697308 YP_978544.1 CDS nadE NC_008769.1 2699962 2702001 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(2699962..2702001) Mycobacterium bovis BCG str. Pasteur 1173P2 4695812 YP_978545.1 CDS BCG_2458 NC_008769.1 2701879 2702157 D hypothetical protein 2701879..2702157 Mycobacterium bovis BCG str. Pasteur 1173P2 4696615 YP_978546.1 CDS proB NC_008769.1 2702287 2703417 R catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase complement(2702287..2703417) Mycobacterium bovis BCG str. Pasteur 1173P2 4695693 YP_978547.1 CDS obgE NC_008769.1 2703417 2704856 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(2703417..2704856) Mycobacterium bovis BCG str. Pasteur 1173P2 4697856 YP_978548.1 CDS rpmA NC_008769.1 2704942 2705202 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(2704942..2705202) Mycobacterium bovis BCG str. Pasteur 1173P2 4696324 YP_978549.1 CDS rplU NC_008769.1 2705217 2705531 R 50S ribosomal protein L21 complement(2705217..2705531) Mycobacterium bovis BCG str. Pasteur 1173P2 4697628 YP_978550.1 CDS dctA NC_008769.1 2705879 2707354 D C4-dicarboxylate-transport transmembrane protein dctA 2705879..2707354 Mycobacterium bovis BCG str. Pasteur 1173P2 4695881 YP_978551.1 CDS rne NC_008769.1 2707293 2710154 R ribonuclease E rne complement(2707293..2710154) Mycobacterium bovis BCG str. Pasteur 1173P2 4696805 YP_978552.1 CDS ndk NC_008769.1 2710484 2710894 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(2710484..2710894) Mycobacterium bovis BCG str. Pasteur 1173P2 4697607 YP_978553.1 CDS BCG_2466c NC_008769.1 2710937 2711308 R integral membrane protein complement(2710937..2711308) Mycobacterium bovis BCG str. Pasteur 1173P2 4696139 YP_978554.1 CDS folC NC_008769.1 2711305 2712768 R folylpolyglutamate synthase folC complement(2711305..2712768) Mycobacterium bovis BCG str. Pasteur 1173P2 4698131 YP_978555.1 CDS valS NC_008769.1 2712765 2715395 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(2712765..2715395) Mycobacterium bovis BCG str. Pasteur 1173P2 4697987 YP_978556.1 CDS BCG_2469c NC_008769.1 2715483 2716742 R Differs from Rv2449c and Mb2476c by 1aa, C273R; hypothetical protein complement(2715483..2716742) Mycobacterium bovis BCG str. Pasteur 1173P2 4697231 YP_978557.1 CDS rpfE NC_008769.1 2716832 2717350 R Differs from Rv2450c by 1aa, Q126R; resuscitation-promoting factor rpfE complement(2716832..2717350) Mycobacterium bovis BCG str. Pasteur 1173P2 4697302 YP_978558.1 CDS BCG_2471 NC_008769.1 2717432 2717830 D Differs from Rv2451 by 1aa, D63N; hypothetical protein 2717432..2717830 Mycobacterium bovis BCG str. Pasteur 1173P2 4699111 YP_978559.1 CDS BCG_2472c NC_008769.1 2718018 2718164 R hypothetical protein complement(2718018..2718164) Mycobacterium bovis BCG str. Pasteur 1173P2 4696095 YP_978560.1 CDS mobA NC_008769.1 2718188 2718793 R MobA; links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide; involved in molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein A complement(2718188..2718793) Mycobacterium bovis BCG str. Pasteur 1173P2 4695592 YP_978561.1 CDS BCG_2474c NC_008769.1 2718795 2719916 R catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin; 2-oxoglutarate ferredoxin oxidoreductase subunit beta complement(2718795..2719916) Mycobacterium bovis BCG str. Pasteur 1173P2 4695566 YP_978562.1 CDS BCG_2475c NC_008769.1 2719913 2721874 R oxidoreductase subunit alpha complement(2719913..2721874) Mycobacterium bovis BCG str. Pasteur 1173P2 4695445 YP_978563.1 CDS BCG_2476c NC_008769.1 2722106 2723362 R integral membrane transport protein complement(2722106..2723362) Mycobacterium bovis BCG str. Pasteur 1173P2 4696196 YP_978564.1 CDS clpX NC_008769.1 2723378 2724658 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(2723378..2724658) Mycobacterium bovis BCG str. Pasteur 1173P2 4695732 YP_978565.1 CDS mmuM NC_008769.1 2724949 2725857 D converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines; homocysteine methyltransferase 2724949..2725857 Mycobacterium bovis BCG str. Pasteur 1173P2 4698060 YP_978566.1 CDS BCG_2479 NC_008769.1 2726024 2727550 D Differs from Mb2486 by 1aa, M55I; integral membrane transport protein 2726024..2727550 Mycobacterium bovis BCG str. Pasteur 1173P2 4698504 YP_978567.1 CDS clpP2 NC_008769.1 2727701 2728345 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(2727701..2728345) Mycobacterium bovis BCG str. Pasteur 1173P2 4696484 YP_978568.1 CDS clpP NC_008769.1 2728342 2728944 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(2728342..2728944) Mycobacterium bovis BCG str. Pasteur 1173P2 4698479 YP_978569.1 CDS tig NC_008769.1 2729061 2730461 R Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor complement(2729061..2730461) Mycobacterium bovis BCG str. Pasteur 1173P2 4698437 YP_978570.1 CDS lipP NC_008769.1 2730825 2732009 D esterase/lipase lipP 2730825..2732009 Mycobacterium bovis BCG str. Pasteur 1173P2 4696330 YP_978571.1 CDS BCG_2484c NC_008769.1 2732029 2732835 R DNA glycosylase complement(2732029..2732835) Mycobacterium bovis BCG str. Pasteur 1173P2 4696902 YP_978572.1 CDS rpiB NC_008769.1 2732841 2733329 R catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B complement(2732841..2733329) Mycobacterium bovis BCG str. Pasteur 1173P2 4696217 YP_978573.1 CDS BCG_2486c NC_008769.1 2733431 2734054 R hypothetical protein complement(2733431..2734054) Mycobacterium bovis BCG str. Pasteur 1173P2 4699113 YP_978574.1 CDS pepN NC_008769.1 2734156 2736741 D Differs from Rv2467 and Mb2494 by 1aa, M18I; aminopeptidase N pepN 2734156..2736741 Mycobacterium bovis BCG str. Pasteur 1173P2 4696640 YP_978575.1 CDS BCG_2488c NC_008769.1 2736814 2737317 R hypothetical protein complement(2736814..2737317) Mycobacterium bovis BCG str. Pasteur 1173P2 4696293 YP_978576.1 CDS BCG_2489c NC_008769.1 2737537 2738205 R Differs from Rv2469c by 2aa, G28S, S99A; hypothetical protein complement(2737537..2738205) Mycobacterium bovis BCG str. Pasteur 1173P2 4696486 YP_978577.1 CDS glbO NC_008769.1 2738348 2738734 D globin (oxygen-binding protein) glbO 2738348..2738734 Mycobacterium bovis BCG str. Pasteur 1173P2 4696625 YP_978578.1 CDS aglA NC_008769.1 2738734 2740374 D Differs from Rv2471 by 1aa, S206W; alpha-glucosidase aglA 2738734..2740374 Mycobacterium bovis BCG str. Pasteur 1173P2 4697397 YP_978579.1 CDS BCG_2492 NC_008769.1 2740442 2740735 D hypothetical protein 2740442..2740735 Mycobacterium bovis BCG str. Pasteur 1173P2 4696510 YP_978580.1 CDS BCG_2493 NC_008769.1 2740738 2741454 D hypothetical protein 2740738..2741454 Mycobacterium bovis BCG str. Pasteur 1173P2 4696411 YP_978581.1 CDS BCG_2494c NC_008769.1 2741486 2742139 R Differs from Mb2501c by 1aa, A30V; hypothetical protein complement(2741486..2742139) Mycobacterium bovis BCG str. Pasteur 1173P2 4696469 YP_978582.1 CDS BCG_2495c NC_008769.1 2742145 2742561 R hypothetical protein complement(2742145..2742561) Mycobacterium bovis BCG str. Pasteur 1173P2 4696213 YP_978583.1 CDS gdh NC_008769.1 2742558 2747429 R In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a 3 bp deletion (cgg-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1623 aa versus 1624 aa). Differs from Rv2476c by 2aa, loss of A501 due to 3 bp deletion and G1042S; NAD-dependent glutamate dehydrogenase gdh complement(2742558..2747429) Mycobacterium bovis BCG str. Pasteur 1173P2 4696231 YP_978584.1 CDS BCG_2497c NC_008769.1 2747533 2749209 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein complement(2747533..2749209) Mycobacterium bovis BCG str. Pasteur 1173P2 4698646 YP_978585.1 CDS BCG_2498 NC_008769.1 2749290 2749775 R hypothetical protein complement(2749290..2749775) Mycobacterium bovis BCG str. Pasteur 1173P2 4696155 YP_978586.1 CDS BCG_2499c NC_008769.1 2750384 2750707 R hypothetical protein complement(2750384..2750707) Mycobacterium bovis BCG str. Pasteur 1173P2 4695703 YP_978587.1 CDS plsB2 NC_008769.1 2750723 2753092 R PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase complement(2750723..2753092) Mycobacterium bovis BCG str. Pasteur 1173P2 4695710 YP_978588.1 CDS plsC NC_008769.1 2753089 2754831 R Differs from Rv2483c by 1aa, G189C; transmembrane phospholipid biosynthesis bifunctionnal l-3-phosphoserine phosphatase/1-acyl-SN-glycerol-3-phosphate acyltransferase complement(2753089..2754831) Mycobacterium bovis BCG str. Pasteur 1173P2 4695944 YP_978589.1 CDS BCG_2502c NC_008769.1 2754828 2756303 R Differs from Rv2484c by 1aa, D466G; hypothetical protein complement(2754828..2756303) Mycobacterium bovis BCG str. Pasteur 1173P2 4695945 YP_978590.1 CDS lipQ NC_008769.1 2756532 2757797 R carboxylesterase lipQ complement(2756532..2757797) Mycobacterium bovis BCG str. Pasteur 1173P2 4695390 YP_978591.1 CDS echA14 NC_008769.1 2758159 2758929 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2758159..2758929 Mycobacterium bovis BCG str. Pasteur 1173P2 4697860 YP_978592.1 CDS PE_PGRS42ab NC_008769.1 2759609 2761192 R In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts, the first due to a single base insertion (*-c) and the second due to a single base deletion (g-*) splits PE_PGRS42 into 3 parts, PE_PGRS42a and PE_PGRS42b and PE_PGRS42d while in Mycobacterium bovis BCG Pasteur, PE_PGRS42a and PE_GRRS42b are fused; PE-PGRS family protein complement(2759609..2761192) Mycobacterium bovis BCG str. Pasteur 1173P2 4695727 YP_978593.1 CDS BCG_2507c NC_008769.1 2761274 2764687 R Differs from Rv2488c and Mb2515c by 1aa E535D; LuxR family transcriptional regulator complement(2761274..2764687) Mycobacterium bovis BCG str. Pasteur 1173P2 4695726 YP_978594.1 CDS BCG_2508c NC_008769.1 2764653 2764952 R hypothetical protein complement(2764653..2764952) Mycobacterium bovis BCG str. Pasteur 1173P2 4695615 YP_978595.1 CDS PE_PGRS43b NC_008769.1 2765061 2768513 R In Mycobacterium tuberculosis strain H37Rv, PE_PGRS43 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 8 bp insertion (*-gggggggg ) splits PE_PGRS43 into 2 parts, PE_PGRS43a and PE_PGRS43b while in Mycobacterium bovis BCG Pasteur, a 1 bp insertion (equivalent to Mycobacterium tuberculosis H37Rv position 2804942-2804943) causes a different frameshift but at same place; PE-PGRS family protein complement(2765061..2768513) Mycobacterium bovis BCG str. Pasteur 1173P2 4695379 YP_978596.1 CDS PE_PGRS43a NC_008769.1 2768605 2770032 R In Mycobacterium tuberculosis strain H37Rv, PE_PGRS43 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 8 bp insertion (*-gggggggg ) splits PE_PGRS43 into 2 parts, PE_PGRS43a and PE_PGRS43b while in Mycobacterium bovis BCG Pasteur, a 1 bp insertion (equivalent to Mycobacterium tuberculosis H37Rv position 2804942-2804943) causes a different frameshift but at same place; PE-PGRS family protein complement(2768605..2770032) Mycobacterium bovis BCG str. Pasteur 1173P2 4695729 YP_978597.1 CDS BCG_2511 NC_008769.1 2770461 2771084 D hypothetical protein 2770461..2771084 Mycobacterium bovis BCG str. Pasteur 1173P2 4695728 YP_978598.1 CDS BCG_2512 NC_008769.1 2771074 2771826 D Differs from Rv2492 by 1aa, D70A; hypothetical protein 2771074..2771826 Mycobacterium bovis BCG str. Pasteur 1173P2 4695577 YP_978599.1 CDS BCG_2513 NC_008769.1 2771879 2772100 D hypothetical protein 2771879..2772100 Mycobacterium bovis BCG str. Pasteur 1173P2 4695487 YP_978600.1 CDS BCG_2514 NC_008769.1 2772106 2772531 D hypothetical protein 2772106..2772531 Mycobacterium bovis BCG str. Pasteur 1173P2 4696245 YP_978601.1 CDS pdhC NC_008769.1 2772554 2773735 R Differs from Rv2495c by 2aa, A107T, W208R; branched-chain alpha-keto acid dehydrogenase subunit E2 complement(2772554..2773735) Mycobacterium bovis BCG str. Pasteur 1173P2 4697003 YP_978602.1 CDS pdhB NC_008769.1 2773732 2774778 R Differs from Rv2496c by 1aa, S201G; pyruvate dehydrogenase E1 component subunit beta pdhB complement(2773732..2774778) Mycobacterium bovis BCG str. Pasteur 1173P2 4695741 YP_978603.1 CDS pdhA NC_008769.1 2774789 2775892 R pyruvate dehydrogenase E1 component subunit alpha pdhA complement(2774789..2775892) Mycobacterium bovis BCG str. Pasteur 1173P2 4695740 YP_978604.1 CDS citE NC_008769.1 2776151 2776972 R citrate (pro-3s)-lyase subunit beta complement(2776151..2776972) Mycobacterium bovis BCG str. Pasteur 1173P2 4695739 YP_978605.1 CDS BCG_2519c NC_008769.1 2776969 2777526 R oxidase regulatory-related protein complement(2776969..2777526) Mycobacterium bovis BCG str. Pasteur 1173P2 4698379 YP_978606.1 CDS fadE19 NC_008769.1 2777523 2778707 R acyl-CoA dehydrogenase fadE19 complement(2777523..2778707) Mycobacterium bovis BCG str. Pasteur 1173P2 4696894 YP_978607.1 CDS accA1 NC_008769.1 2778712 2780676 R acetyl-/propionyl-coenzyme A carboxylase alpha chain subunit alpha accA1 complement(2778712..2780676) Mycobacterium bovis BCG str. Pasteur 1173P2 4699117 YP_978608.1 CDS accD1 NC_008769.1 2780681 2782270 R Differs from Rv2502c by 2aa, S77G, L343F; acetyl-/propionyl-coa carboxylase subunit beta accD1 complement(2780681..2782270) Mycobacterium bovis BCG str. Pasteur 1173P2 4698741 YP_978609.1 CDS scoB NC_008769.1 2782267 2782923 R succinyl-CoA:3-ketoacid-coenzyme A transferase subunit beta scoB complement(2782267..2782923) Mycobacterium bovis BCG str. Pasteur 1173P2 4698737 YP_978610.1 CDS scoA NC_008769.1 2782920 2783666 R succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha scoA complement(2782920..2783666) Mycobacterium bovis BCG str. Pasteur 1173P2 4697897 YP_978611.1 CDS fadD35 NC_008769.1 2783749 2785392 R activates fatty acids by binding to coenzyme A; AMP-binding protein complement(2783749..2785392) Mycobacterium bovis BCG str. Pasteur 1173P2 4697896 YP_978612.1 CDS BCG_2526 NC_008769.1 2785508 2786155 D TetR family transcriptional regulator 2785508..2786155 Mycobacterium bovis BCG str. Pasteur 1173P2 4697147 YP_978613.1 CDS BCG_2527 NC_008769.1 2786234 2787055 D proline rich membrane protein 2786234..2787055 Mycobacterium bovis BCG str. Pasteur 1173P2 4698111 YP_978614.1 CDS BCG_2528c NC_008769.1 2787052 2788389 R integral membrane leucine and alanine rich protein complement(2787052..2788389) Mycobacterium bovis BCG str. Pasteur 1173P2 4696142 YP_978615.1 CDS BCG_2529 NC_008769.1 2788474 2789280 D short-chain type dehydrogenase/reductase 2788474..2789280 Mycobacterium bovis BCG str. Pasteur 1173P2 4696687 YP_978616.1 CDS BCG_2530c NC_008769.1 2789284 2790885 R hypothetical protein complement(2789284..2790885) Mycobacterium bovis BCG str. Pasteur 1173P2 4696838 YP_978617.1 CDS orn NC_008769.1 2790953 2791600 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 2790953..2791600 Mycobacterium bovis BCG str. Pasteur 1173P2 4698817 YP_978618.1 CDS BCG_2532c NC_008769.1 2792352 2793599 R transposase IS1081 complement(2792352..2793599) Mycobacterium bovis BCG str. Pasteur 1173P2 4696331 YP_978619.1 CDS BCG_2533 NC_008769.1 2793599 2793736 D hypothetical protein 2793599..2793736 Mycobacterium bovis BCG str. Pasteur 1173P2 4696380 YP_978620.1 CDS BCG_2534 NC_008769.1 2793957 2794379 D Differs from Rv2513 by 1aa, K122T; hypothetical protein 2793957..2794379 Mycobacterium bovis BCG str. Pasteur 1173P2 4696777 YP_978621.1 CDS BCG_2535c NC_008769.1 2794673 2795134 R hypothetical protein complement(2794673..2795134) Mycobacterium bovis BCG str. Pasteur 1173P2 4696362 YP_978622.1 CDS BCG_2536c NC_008769.1 2795140 2796387 R hypothetical protein complement(2795140..2796387) Mycobacterium bovis BCG str. Pasteur 1173P2 4698441 YP_978623.1 CDS BCG_2537c NC_008769.1 2796506 2797309 R hypothetical protein complement(2796506..2797309) Mycobacterium bovis BCG str. Pasteur 1173P2 4697838 YP_978624.1 CDS BCG_2538c NC_008769.1 2797306 2797557 R hypothetical protein complement(2797306..2797557) Mycobacterium bovis BCG str. Pasteur 1173P2 4698936 YP_978625.1 CDS lppS NC_008769.1 2797905 2799131 R lipoprotein lppS complement(2797905..2799131) Mycobacterium bovis BCG str. Pasteur 1173P2 4697743 YP_978626.1 CDS PE26 NC_008769.1 2799581 2801059 D Identical to Rv2519 but differs from Mb2548 by 1aa, G173A, due to 2bp substitution at position equivalent to Mycobacterium bovis 2803099-2803100 cc-gg; PE family protein 2799581..2801059 Mycobacterium bovis BCG str. Pasteur 1173P2 4697283 YP_978627.1 CDS BCG_2541c NC_008769.1 2801184 2801411 R hypothetical protein complement(2801184..2801411) Mycobacterium bovis BCG str. Pasteur 1173P2 4697126 YP_978628.1 CDS bcp NC_008769.1 2801480 2801953 D Differs from Mb2550 by 1aa, V122M; bacterioferritin comigratory protein bcp 2801480..2801953 Mycobacterium bovis BCG str. Pasteur 1173P2 4695599 YP_978629.1 CDS BCG_2543c NC_008769.1 2801925 2803337 R hypothetical protein complement(2801925..2803337) Mycobacterium bovis BCG str. Pasteur 1173P2 4696638 YP_978630.1 CDS acpS NC_008769.1 2803334 2803726 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(2803334..2803726) Mycobacterium bovis BCG str. Pasteur 1173P2 4696533 YP_978631.1 CDS fas NC_008769.1 2803919 2813128 R fatty acid synthase fas complement(2803919..2813128) Mycobacterium bovis BCG str. Pasteur 1173P2 4697832 YP_978632.1 CDS BCG_2546c NC_008769.1 2813648 2814370 R hypothetical protein complement(2813648..2814370) Mycobacterium bovis BCG str. Pasteur 1173P2 4695683 YP_978633.1 CDS BCG_2547 NC_008769.1 2814887 2815114 D hypothetical protein 2814887..2815114 Mycobacterium bovis BCG str. Pasteur 1173P2 4696999 YP_978634.1 CDS BCG_2548 NC_008769.1 2815111 2815512 D hypothetical protein 2815111..2815512 Mycobacterium bovis BCG str. Pasteur 1173P2 4696071 YP_978635.1 CDS mrr NC_008769.1 2815547 2816467 R Differs from Rv2528c by 1aa, L94P, and Mb2557c by 2aa, L94P, E259Q; restriction system protein mrr complement(2815547..2816467) Mycobacterium bovis BCG str. Pasteur 1173P2 4698031 YP_978636.1 CDS BCG_2550 NC_008769.1 2816671 2818062 D Differs from Mb2558 by 1aa, G94E; hypothetical protein 2816671..2818062 Mycobacterium bovis BCG str. Pasteur 1173P2 4698097 YP_978637.1 CDS BCG_2551c NC_008769.1 2818063 2818482 R hypothetical protein complement(2818063..2818482) Mycobacterium bovis BCG str. Pasteur 1173P2 4695744 YP_978638.1 CDS BCG_2552c NC_008769.1 2818479 2818703 R hypothetical protein complement(2818479..2818703) Mycobacterium bovis BCG str. Pasteur 1173P2 4697016 YP_978639.1 CDS BCG_2553c NC_008769.1 2818734 2821577 R amino acid decarboxylase complement(2818734..2821577) Mycobacterium bovis BCG str. Pasteur 1173P2 4698187 YP_978640.1 CDS BCG_2554c NC_008769.1 2821649 2822050 R hypothetical protein complement(2821649..2822050) Mycobacterium bovis BCG str. Pasteur 1173P2 4698448 YP_978641.1 CDS nusB NC_008769.1 2822050 2822520 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(2822050..2822520) Mycobacterium bovis BCG str. Pasteur 1173P2 4697824 YP_978642.1 CDS efp NC_008769.1 2822523 2823086 R Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P complement(2822523..2823086) Mycobacterium bovis BCG str. Pasteur 1173P2 4697206 YP_978643.1 CDS pepQ NC_008769.1 2823096 2824214 R cytoplasmic peptidase pepQ complement(2823096..2824214) Mycobacterium bovis BCG str. Pasteur 1173P2 4697303 YP_978644.1 CDS BCG_2558 NC_008769.1 2824248 2824940 D hypothetical protein 2824248..2824940 Mycobacterium bovis BCG str. Pasteur 1173P2 4696294 YP_978645.1 CDS aroD NC_008769.1 2824944 2825387 R catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase complement(2824944..2825387) Mycobacterium bovis BCG str. Pasteur 1173P2 4699191 YP_978646.1 CDS aroB NC_008769.1 2825384 2826472 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(2825384..2826472) Mycobacterium bovis BCG str. Pasteur 1173P2 4696247 YP_978647.1 CDS aroK NC_008769.1 2826469 2826999 R catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase complement(2826469..2826999) Mycobacterium bovis BCG str. Pasteur 1173P2 4697902 YP_978648.1 CDS aroF NC_008769.1 2827003 2828208 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(2827003..2828208) Mycobacterium bovis BCG str. Pasteur 1173P2 4697459 YP_978649.1 CDS BCG_2563 NC_008769.1 2828223 2828630 D hypothetical protein 2828223..2828630 Mycobacterium bovis BCG str. Pasteur 1173P2 4696606 YP_978650.1 CDS BCG_2564 NC_008769.1 2828926 2830137 D Differs from Rv2542 by 1aa, A211T; hypothetical protein 2828926..2830137 Mycobacterium bovis BCG str. Pasteur 1173P2 4698320 YP_978651.1 CDS lppA NC_008769.1 2830264 2830923 D lipoprotein lppA 2830264..2830923 Mycobacterium bovis BCG str. Pasteur 1173P2 4699122 YP_978652.1 CDS lprR NC_008769.1 2830920 2831579 D In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, there is a 656 bp insertion, relative to Mycobacterium tuberculosis strain H37Rv, which leads to lppR gene, probably by duplication of llpA or lppB; lipoprotein lprR 2830920..2831579 Mycobacterium bovis BCG str. Pasteur 1173P2 4699199 YP_978653.1 CDS lppB NC_008769.1 2831576 2832238 D lipoprotein lppB 2831576..2832238 Mycobacterium bovis BCG str. Pasteur 1173P2 4697258 YP_978654.1 CDS BCG_2568 NC_008769.1 2832235 2832513 D hypothetical protein 2832235..2832513 Mycobacterium bovis BCG str. Pasteur 1173P2 4699200 YP_978655.1 CDS BCG_2569 NC_008769.1 2832606 2833019 D hypothetical protein 2832606..2833019 Mycobacterium bovis BCG str. Pasteur 1173P2 4696592 YP_978656.1 CDS BCG_2570 NC_008769.1 2833058 2833315 D hypothetical protein 2833058..2833315 Mycobacterium bovis BCG str. Pasteur 1173P2 4699333 YP_978657.1 CDS BCG_2571 NC_008769.1 2833312 2833689 D hypothetical protein 2833312..2833689 Mycobacterium bovis BCG str. Pasteur 1173P2 4697065 YP_978658.1 CDS BCG_2572c NC_008769.1 2834179 2834574 R hypothetical protein complement(2834179..2834574) Mycobacterium bovis BCG str. Pasteur 1173P2 4695775 YP_978659.1 CDS BCG_2573c NC_008769.1 2834571 2834816 R hypothetical protein complement(2834571..2834816) Mycobacterium bovis BCG str. Pasteur 1173P2 4697634 YP_978660.1 CDS BCG_2574c NC_008769.1 2835227 2835646 R hypothetical protein complement(2835227..2835646) Mycobacterium bovis BCG str. Pasteur 1173P2 4697604 YP_978661.2 CDS aroE NC_008769.1 2835658 2836485 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(2835658..2836485) Mycobacterium bovis BCG str. Pasteur 1173P2 4697739 YP_978662.1 CDS BCG_2576c NC_008769.1 2836463 2837716 R hypothetical protein complement(2836463..2837716) Mycobacterium bovis BCG str. Pasteur 1173P2 4699267 YP_978663.1 CDS BCG_2577c NC_008769.1 2837709 2838221 R similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein complement(2837709..2838221) Mycobacterium bovis BCG str. Pasteur 1173P2 4697454 YP_978664.1 CDS alaS NC_008769.1 2838222 2840936 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(2838222..2840936) Mycobacterium bovis BCG str. Pasteur 1173P2 4696367 YP_978665.1 CDS BCG_2579c NC_008769.1 2841027 2841416 R hypothetical protein complement(2841027..2841416) Mycobacterium bovis BCG str. Pasteur 1173P2 4695651 YP_978666.1 CDS BCG_2580 NC_008769.1 2841523 2842197 D hypothetical protein 2841523..2842197 Mycobacterium bovis BCG str. Pasteur 1173P2 4697332 YP_978667.1 CDS BCG_2581 NC_008769.1 2842282 2842992 D hypothetical protein 2842282..2842992 Mycobacterium bovis BCG str. Pasteur 1173P2 4695673 YP_978668.1 CDS BCG_2582c NC_008769.1 2843022 2844380 R Differs from Rv2559c by 1aa, D317G; recombination factor protein RarA complement(2843022..2844380) Mycobacterium bovis BCG str. Pasteur 1173P2 4696480 YP_978669.1 CDS BCG_2583 NC_008769.1 2844526 2845503 D Differs from Rv2560 by 1aa, L210V; proline and glycine rich transmembrane protein 2844526..2845503 Mycobacterium bovis BCG str. Pasteur 1173P2 4696725 YP_978670.1 CDS BCG_2584 NC_008769.1 2845860 2846597 D In Mycobacterium tuberculosis strain H37Rv, Rv2561 and Rv2562 exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base deletion (g-*) results in a single product which is more similar to Rv2561; hypothetical protein 2845860..2846597 Mycobacterium bovis BCG str. Pasteur 1173P2 4696692 YP_978671.1 CDS BCG_2585 NC_008769.1 2846740 2847789 D glutamine-transport transmembrane protein ABC transporter 2846740..2847789 Mycobacterium bovis BCG str. Pasteur 1173P2 4698429 YP_978672.1 CDS glnQ NC_008769.1 2847792 2848784 D glutamine-transport ATP-binding protein ABC transporter glnQ 2847792..2848784 Mycobacterium bovis BCG str. Pasteur 1173P2 4698399 YP_978673.1 CDS BCG_2587 NC_008769.1 2849061 2850812 D hypothetical protein 2849061..2850812 Mycobacterium bovis BCG str. Pasteur 1173P2 4697948 YP_978674.1 CDS BCG_2588 NC_008769.1 2850823 2852424 D In Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 2 bp deletion (gc-*) splits Rv2566 into 2 parts. Differs from first part of Rv2566 by 3aa, S10G, S270A, L315V and from Mb2595 by 1aa, L315V; hypothetical protein 2850823..2852424 Mycobacterium bovis BCG str. Pasteur 1173P2 4697447 YP_978675.1 CDS BCG_2589 NC_008769.1 2852450 2854243 D In Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as a single gene. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a frameshift due to a 2 bp deletion (gc-*) splits Rv2566 into 2 parts; Differs from Rv2566 by 2aa, P67L, E326G, and from Mb2596 by 1aa, E326G; hypothetical protein 2852450..2854243 Mycobacterium bovis BCG str. Pasteur 1173P2 4695373 YP_978676.1 CDS BCG_2590 NC_008769.1 2854243 2856897 D Differs from Rv2567 by 1aa, R645Q; hypothetical protein 2854243..2856897 Mycobacterium bovis BCG str. Pasteur 1173P2 4696717 YP_978677.1 CDS BCG_2591c NC_008769.1 2856894 2857919 R hypothetical protein complement(2856894..2857919) Mycobacterium bovis BCG str. Pasteur 1173P2 4698511 YP_978678.1 CDS BCG_2592c NC_008769.1 2857912 2858856 R hypothetical protein complement(2857912..2858856) Mycobacterium bovis BCG str. Pasteur 1173P2 4698987 YP_978679.1 CDS BCG_2593 NC_008769.1 2858960 2859349 D hypothetical protein 2858960..2859349 Mycobacterium bovis BCG str. Pasteur 1173P2 4698312 YP_978680.1 CDS BCG_2594c NC_008769.1 2859341 2860408 R Differs from Rv2571c and Mb2601c by 1aa, C68R; transmembrane alanine and valine and leucine rich protein complement(2859341..2860408) Mycobacterium bovis BCG str. Pasteur 1173P2 4697295 YP_978681.1 CDS aspS NC_008769.1 2860415 2862250 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(2860415..2862250) Mycobacterium bovis BCG str. Pasteur 1173P2 4697280 YP_978682.1 CDS BCG_2596 NC_008769.1 2862490 2863230 D ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 2862490..2863230 Mycobacterium bovis BCG str. Pasteur 1173P2 4699328 YP_978683.1 CDS BCG_2597 NC_008769.1 2863253 2863756 D hypothetical protein 2863253..2863756 Mycobacterium bovis BCG str. Pasteur 1173P2 4698814 YP_978684.1 CDS BCG_2598 NC_008769.1 2863786 2864667 D membrane glycine rich protein 2863786..2864667 Mycobacterium bovis BCG str. Pasteur 1173P2 4698112 YP_978685.1 CDS BCG_2599c NC_008769.1 2864673 2865137 R hypothetical protein complement(2864673..2865137) Mycobacterium bovis BCG str. Pasteur 1173P2 4695689 YP_978686.1 CDS BCG_2600 NC_008769.1 2865365 2866954 D In Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG Pasteur, Rv2577 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (g-a) splits Rv2577 into 2 parts, Mb2607 and Mb2608; hypothetical protein 2865365..2866954 Mycobacterium bovis BCG str. Pasteur 1173P2 4698029 YP_978687.1 CDS BCG_2601c NC_008769.1 2866956 2867978 R hypothetical protein complement(2866956..2867978) Mycobacterium bovis BCG str. Pasteur 1173P2 4698643 YP_978688.1 CDS dhaA NC_008769.1 2868086 2868988 D catalyzes the cleavage of carbon-halogen bonds in aliphatic compounds forming a primary alcohol and a halide; haloalkane dehalogenase 2868086..2868988 Mycobacterium bovis BCG str. Pasteur 1173P2 4698043 YP_978689.1 CDS hisS NC_008769.1 2869268 2870539 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(2869268..2870539) Mycobacterium bovis BCG str. Pasteur 1173P2 4696840 YP_978690.1 CDS BCG_2604c NC_008769.1 2870536 2871210 R glyoxalase II complement(2870536..2871210) Mycobacterium bovis BCG str. Pasteur 1173P2 4696099 YP_978691.1 CDS ppiB NC_008769.1 2871261 2872187 D Differs from Rv2582 by 1aa, F66V; peptidyl-prolyl cis-trans isomerase B ppiB 2871261..2872187 Mycobacterium bovis BCG str. Pasteur 1173P2 4697677 YP_978692.1 CDS relA NC_008769.1 2872273 2874645 R GTP pyrophosphokinase relA complement(2872273..2874645) Mycobacterium bovis BCG str. Pasteur 1173P2 4698101 YP_978693.1 CDS apt NC_008769.1 2874676 2875347 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(2874676..2875347) Mycobacterium bovis BCG str. Pasteur 1173P2 4696795 YP_978694.1 CDS BCG_2608c NC_008769.1 2875451 2877124 R Differs from Rv2585c by 1aa, S462C; lipoprotein complement(2875451..2877124) Mycobacterium bovis BCG str. Pasteur 1173P2 4695940 YP_978695.1 CDS secF NC_008769.1 2877130 2878458 R forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF complement(2877130..2878458) Mycobacterium bovis BCG str. Pasteur 1173P2 4699076 YP_978696.1 CDS secD NC_008769.1 2878462 2880183 R part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD complement(2878462..2880183) Mycobacterium bovis BCG str. Pasteur 1173P2 4697709 YP_978697.1 CDS yajC NC_008769.1 2880293 2880640 R member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC complement(2880293..2880640) Mycobacterium bovis BCG str. Pasteur 1173P2 4697706 YP_978698.1 CDS gabT NC_008769.1 2880807 2882156 D catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2880807..2882156 Mycobacterium bovis BCG str. Pasteur 1173P2 4696673 YP_978699.1 CDS fadD9 NC_008769.1 2882318 2885824 D Differs from Rv2590 by 1aa, Y309F, and from Mb2621 by 1aa, A1106T; fatty-acid-CoA ligase fadD9 2882318..2885824 Mycobacterium bovis BCG str. Pasteur 1173P2 4695551 YP_978700.1 CDS PE_PGRS44 NC_008769.1 2885998 2887638 D Differs from Rv2591 by extra 3aa resulting from same 9 bp in-frame insertion as in Mycobacterium bovis (*-ggcggcacc) and by 2aa S415G, D463G; PE-PGRS family protein 2885998..2887638 Mycobacterium bovis BCG str. Pasteur 1173P2 4695871 YP_978701.1 CDS ruvB NC_008769.1 2887655 2888689 R promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB complement(2887655..2888689) Mycobacterium bovis BCG str. Pasteur 1173P2 4695730 YP_978702.1 CDS ruvA NC_008769.1 2888686 2889276 R plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA complement(2888686..2889276) Mycobacterium bovis BCG str. Pasteur 1173P2 4697807 YP_978703.1 CDS ruvC NC_008769.1 2889273 2889839 R endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase complement(2889273..2889839) Mycobacterium bovis BCG str. Pasteur 1173P2 4697806 YP_978704.1 CDS BCG_2618 NC_008769.1 2889948 2890193 D hypothetical protein 2889948..2890193 Mycobacterium bovis BCG str. Pasteur 1173P2 4697808 YP_978705.1 CDS BCG_2619 NC_008769.1 2890190 2890594 D Differs from Rv2596 by 1aa, R77C; hypothetical protein 2890190..2890594 Mycobacterium bovis BCG str. Pasteur 1173P2 4698348 YP_978706.1 CDS BCG_2620 NC_008769.1 2890811 2891431 D hypothetical protein 2890811..2891431 Mycobacterium bovis BCG str. Pasteur 1173P2 4697394 YP_978707.1 CDS BCG_2621 NC_008769.1 2891442 2891936 D hypothetical protein 2891442..2891936 Mycobacterium bovis BCG str. Pasteur 1173P2 4697943 YP_978708.1 CDS BCG_2622 NC_008769.1 2891933 2892364 D Differs from Rv2599 by 1aa, I12S; hypothetical protein 2891933..2892364 Mycobacterium bovis BCG str. Pasteur 1173P2 4697014 YP_978709.1 CDS BCG_2623 NC_008769.1 2892446 2892652 D First 64 aa identical to N-terminal part of Rv2600 and Mb2631 but then frameshifts due to 10bp deletion at position equivalent to Mycobacterium bovis coordinates 2895640-2895649. Results in BCG Pasteur orthologs of Mb2631 and Rv2600 being in two parts; integral membrane protein 2892446..2892652 Mycobacterium bovis BCG str. Pasteur 1173P2 4697649 YP_978710.1 CDS BCG_2624 NC_008769.1 2892658 2892837 D All 59aa are identical to C-terminal part of Rv2600 and Mb2631 owing to frameshifts due to 10bp deletion at position equivalent to Mycobacterium bovis coordinates 2895640-2895649. Results in BCG Pasteur orthologs of Mb2631 and Rv2600 being in two parts, both of which encode hydrophobic proteins; integral membrane protein 2892658..2892837 Mycobacterium bovis BCG str. Pasteur 1173P2 4698268 YP_978711.1 CDS speE NC_008769.1 2892834 2894405 D catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 2892834..2894405 Mycobacterium bovis BCG str. Pasteur 1173P2 4696612 YP_978712.1 CDS BCG_2626 NC_008769.1 2894516 2894803 D hypothetical protein 2894516..2894803 Mycobacterium bovis BCG str. Pasteur 1173P2 4695622 YP_978713.1 CDS BCG_2627 NC_008769.1 2894790 2895230 D hypothetical protein 2894790..2895230 Mycobacterium bovis BCG str. Pasteur 1173P2 4698327 YP_978714.1 CDS BCG_2628c NC_008769.1 2895251 2896006 R hypothetical protein complement(2895251..2896006) Mycobacterium bovis BCG str. Pasteur 1173P2 4698952 YP_978715.1 CDS BCG_2629c NC_008769.1 2896139 2896735 R with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT complement(2896139..2896735) Mycobacterium bovis BCG str. Pasteur 1173P2 4699057 YP_978716.1 CDS tesB2 NC_008769.1 2896743 2897588 R Differs from Rv2605c by 1aa, L85F; acyl-CoA thioesterase II tesB2 complement(2896743..2897588) Mycobacterium bovis BCG str. Pasteur 1173P2 4697047 YP_978717.1 CDS BCG_2631c NC_008769.1 2897617 2898516 R with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS complement(2897617..2898516) Mycobacterium bovis BCG str. Pasteur 1173P2 4696851 YP_978718.1 CDS pdxH NC_008769.1 2898644 2899318 D catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 2898644..2899318 Mycobacterium bovis BCG str. Pasteur 1173P2 4695772 YP_978719.1 CDS PPE42 NC_008769.1 2899492 2901234 D Differs from Rv2608 by 1aa, S281P; PPE family protein 2899492..2901234 Mycobacterium bovis BCG str. Pasteur 1173P2 4695742 YP_978720.1 CDS BCG_2634c NC_008769.1 2901256 2902311 R hypothetical protein complement(2901256..2902311) Mycobacterium bovis BCG str. Pasteur 1173P2 4697820 YP_978721.1 CDS pimA NC_008769.1 2902311 2903447 R Alpha-mannosyltransferase pimA complement(2902311..2903447) Mycobacterium bovis BCG str. Pasteur 1173P2 4696309 YP_978722.1 CDS BCG_2636c NC_008769.1 2903458 2904408 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(2903458..2904408) Mycobacterium bovis BCG str. Pasteur 1173P2 4697039 YP_978723.1 CDS pgsA1 NC_008769.1 2904405 2905058 R phosphatidylinositol synthase pgsA1 complement(2904405..2905058) Mycobacterium bovis BCG str. Pasteur 1173P2 4698001 YP_978724.1 CDS BCG_2638c NC_008769.1 2905055 2905642 R hypothetical protein complement(2905055..2905642) Mycobacterium bovis BCG str. Pasteur 1173P2 4698856 YP_978725.1 CDS thrS NC_008769.1 2905635 2907713 R catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase complement(2905635..2907713) Mycobacterium bovis BCG str. Pasteur 1173P2 4698023 YP_978726.1 CDS BCG_2640 NC_008769.1 2907822 2908049 D Differs from Mb2647 by 1aa, R57H; hypothetical protein 2907822..2908049 Mycobacterium bovis BCG str. Pasteur 1173P2 4695910 YP_978727.1 CDS PE_PGRS45b NC_008769.1 2908046 2909215 R In Mycobacterium bovis, a 9 bp in-frame insertion (*-ccgccgttt) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 461 aa). In Mycobacterium bovis BCG Pasteur, a 7bp deletion at position corresponding to M. bovis 2944835-2944841 splits PE_PGRS45 in two parts; PE-PGRS family protein complement(2908046..2909215) Mycobacterium bovis BCG str. Pasteur 1173P2 4698252 YP_978728.1 CDS PE_PGRS45a NC_008769.1 2909203 2909433 R In Mycobacterium bovis, a 9 bp in-frame insertion (*-ccgccgttt) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 461 aa). In Mycobacterium bovis BCG Pasteur, a 7bp deletion at position corresponding to M. bovis 2944835-2944841 splits PE_PGRS45 in two parts. Differs from Rv2615c by 1aa, V40A; PE-PGRS family protein complement(2909203..2909433) Mycobacterium bovis BCG str. Pasteur 1173P2 4695666 YP_978729.1 CDS BCG_2643 NC_008769.1 2909778 2910278 D Differs from Rv2616 by 1aa, I72V; hypothetical protein 2909778..2910278 Mycobacterium bovis BCG str. Pasteur 1173P2 4695665 YP_978730.1 CDS BCG_2644c NC_008769.1 2910295 2910735 R hypothetical protein complement(2910295..2910735) Mycobacterium bovis BCG str. Pasteur 1173P2 4698205 YP_978731.1 CDS BCG_2645 NC_008769.1 2910882 2911559 D hypothetical protein 2910882..2911559 Mycobacterium bovis BCG str. Pasteur 1173P2 4698136 YP_978732.1 CDS BCG_2646c NC_008769.1 2911544 2911897 R hypothetical protein complement(2911544..2911897) Mycobacterium bovis BCG str. Pasteur 1173P2 4698326 YP_978733.1 CDS BCG_2647c NC_008769.1 2911910 2912335 R hypothetical protein complement(2911910..2912335) Mycobacterium bovis BCG str. Pasteur 1173P2 4698162 YP_978734.1 CDS BCG_2648c NC_008769.1 2912332 2913003 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 3 bp deletion (ggg-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (223 aa versus 224 aa) due to deletion of 1aa after position 194; transcriptional regulatory protein complement(2912332..2913003) Mycobacterium bovis BCG str. Pasteur 1173P2 4698251 YP_978735.1 CDS BCG_2649 NC_008769.1 2913081 2913902 D methyltransferase 2913081..2913902 Mycobacterium bovis BCG str. Pasteur 1173P2 4698196 YP_978736.1 CDS TB31.7 NC_008769.1 2914038 2914931 D hypothetical protein 2914038..2914931 Mycobacterium bovis BCG str. Pasteur 1173P2 4698189 YP_978737.1 CDS BCG_2651c NC_008769.1 2914934 2915752 R hypothetical protein complement(2914934..2915752) Mycobacterium bovis BCG str. Pasteur 1173P2 4696423 YP_978738.1 CDS BCG_2652c NC_008769.1 2915767 2916948 R transmembrane alanine and leucine rich protein complement(2915767..2916948) Mycobacterium bovis BCG str. Pasteur 1173P2 4698262 YP_978739.1 CDS BCG_2653c NC_008769.1 2917007 2917438 R hypothetical protein complement(2917007..2917438) Mycobacterium bovis BCG str. Pasteur 1173P2 4697756 YP_978740.1 CDS BCG_2654c NC_008769.1 2917952 2919193 R Differs from Rv2627c by 1aa, G104R; hypothetical protein complement(2917952..2919193) Mycobacterium bovis BCG str. Pasteur 1173P2 4695421 YP_978741.1 CDS BCG_2655 NC_008769.1 2919503 2919865 D Differs from Rv2628 by 1aa, L59S, and from Mb2661 by 1aa, P68R; hypothetical protein 2919503..2919865 Mycobacterium bovis BCG str. Pasteur 1173P2 4698201 YP_978742.1 CDS BCG_2656 NC_008769.1 2920212 2921336 D hypothetical protein 2920212..2921336 Mycobacterium bovis BCG str. Pasteur 1173P2 4696239 YP_978743.1 CDS BCG_2657 NC_008769.1 2921338 2921877 D hypothetical protein 2921338..2921877 Mycobacterium bovis BCG str. Pasteur 1173P2 4696699 YP_978744.1 CDS BCG_2658 NC_008769.1 2922016 2923314 D hypothetical protein 2922016..2923314 Mycobacterium bovis BCG str. Pasteur 1173P2 4696601 YP_978745.1 CDS BCG_2659c NC_008769.1 2923353 2923634 R hypothetical protein complement(2923353..2923634) Mycobacterium bovis BCG str. Pasteur 1173P2 4699175 YP_978746.1 CDS BCG_2660c NC_008769.1 2923779 2924264 R hypothetical protein complement(2923779..2924264) Mycobacterium bovis BCG str. Pasteur 1173P2 4696801 YP_978747.1 CDS PE_PGRS46 NC_008769.1 2924549 2926951 R In Mycobacterium bovis BCG Pasteur, an in-frame insertion of 66 bp, leads to a longer product compared to Mycobacterium bovis and Mycobacterium tuberculosis strain H37Rv (800 aa versus 778 aa); PE-PGRS family protein complement(2924549..2926951) Mycobacterium bovis BCG str. Pasteur 1173P2 4697611 YP_978748.1 CDS BCG_2662 NC_008769.1 2926980 2927222 D hypothetical protein 2926980..2927222 Mycobacterium bovis BCG str. Pasteur 1173P2 4695667 YP_978749.1 CDS BCG_2663 NC_008769.1 2927223 2927900 D hypothetical protein 2927223..2927900 Mycobacterium bovis BCG str. Pasteur 1173P2 4697377 YP_978750.1 CDS dedA NC_008769.1 2928096 2928752 D transmembrane protein dedA 2928096..2928752 Mycobacterium bovis BCG str. Pasteur 1173P2 4695536 YP_978751.1 CDS BCG_2665 NC_008769.1 2928915 2929361 D hypothetical protein 2928915..2929361 Mycobacterium bovis BCG str. Pasteur 1173P2 4696394 YP_978752.1 CDS BCG_2666c NC_008769.1 2929536 2929868 R hypothetical protein complement(2929536..2929868) Mycobacterium bovis BCG str. Pasteur 1173P2 4697060 YP_978753.1 CDS BCG_2667c NC_008769.1 2929988 2930347 R ArsR family transcriptional regulator complement(2929988..2930347) Mycobacterium bovis BCG str. Pasteur 1173P2 4696621 YP_978754.1 CDS cadI NC_008769.1 2930449 2930907 D cadmium inducible protein cadI 2930449..2930907 Mycobacterium bovis BCG str. Pasteur 1173P2 4695638 YP_978755.1 CDS BCG_2669 NC_008769.1 2931043 2931423 D ArsR family transcriptional regulator 2931043..2931423 Mycobacterium bovis BCG str. Pasteur 1173P2 4696157 YP_978756.1 CDS arsC NC_008769.1 2931420 2932916 D Differs from Rv2643 by 1 aa A455V; arsenic-transport integral membrane protein arsC 2931420..2932916 Mycobacterium bovis BCG str. Pasteur 1173P2 4696365 YP_978757.1 CDS BCG_2671c NC_008769.1 2933043 2933360 R hypothetical protein complement(2933043..2933360) Mycobacterium bovis BCG str. Pasteur 1173P2 4695825 YP_978758.1 CDS BCG_2672c NC_008769.1 2934497 2934718 R In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a large 10982 bp deletion (RD11 region) leads to deletion of genes between Rv2645 and Rv2659c compared to Mycobacterium tuberculosis strain H37Rv; hypothetical protein complement(2934497..2934718) Mycobacterium bovis BCG str. Pasteur 1173P2 4695656 YP_978759.1 CDS BCG_2673c NC_008769.1 2934715 2935104 R hypothetical protein complement(2934715..2935104) Mycobacterium bovis BCG str. Pasteur 1173P2 4697341 YP_978760.1 CDS BCG_2674 NC_008769.1 2935010 2935282 D hypothetical protein 2935010..2935282 Mycobacterium bovis BCG str. Pasteur 1173P2 4695906 YP_978761.1 CDS BCG_2675 NC_008769.1 2935381 2935614 D hypothetical protein 2935381..2935614 Mycobacterium bovis BCG str. Pasteur 1173P2 4696835 YP_978762.1 CDS BCG_2676 NC_008769.1 2935625 2935879 D hypothetical protein 2935625..2935879 Mycobacterium bovis BCG str. Pasteur 1173P2 4696404 YP_978763.1 CDS BCG_2677c NC_008769.1 2936108 2936599 R hypothetical protein complement(2936108..2936599) Mycobacterium bovis BCG str. Pasteur 1173P2 4696812 YP_978764.1 CDS BCG_2678 NC_008769.1 2936227 2936508 D hypothetical protein 2936227..2936508 Mycobacterium bovis BCG str. Pasteur 1173P2 4697979 YP_978765.1 CDS BCG_2679 NC_008769.1 2936599 2937402 D transposase for insertion sequence element IS1081 2936599..2937402 Mycobacterium bovis BCG str. Pasteur 1173P2 4695869 YP_978766.1 CDS clpX' NC_008769.1 2937424 2938182 D ATP-dependent protease ATP-binding subunit clpX' 2937424..2938182 Mycobacterium bovis BCG str. Pasteur 1173P2 4697616 YP_978767.1 CDS BCG_2681 NC_008769.1 2938261 2938782 D Differs from Rv2668 by 2aa R3H and K162E; hypothetical protein 2938261..2938782 Mycobacterium bovis BCG str. Pasteur 1173P2 4698514 YP_978768.1 CDS BCG_2682 NC_008769.1 2938811 2939281 D hypothetical protein 2938811..2939281 Mycobacterium bovis BCG str. Pasteur 1173P2 4697567 YP_978769.1 CDS BCG_2683c NC_008769.1 2939259 2940368 R hypothetical protein complement(2939259..2940368) Mycobacterium bovis BCG str. Pasteur 1173P2 4696289 YP_978770.1 CDS ribD NC_008769.1 2940367 2941143 D hypothetical protein 2940367..2941143 Mycobacterium bovis BCG str. Pasteur 1173P2 4698423 YP_978771.1 CDS BCG_2685 NC_008769.1 2941210 2942796 D Differs from Rv2672 by 1aa D317H; protease 2941210..2942796 Mycobacterium bovis BCG str. Pasteur 1173P2 4696891 YP_978772.1 CDS BCG_2686 NC_008769.1 2942819 2944120 D hypothetical protein 2942819..2944120 Mycobacterium bovis BCG str. Pasteur 1173P2 4696655 YP_978773.1 CDS BCG_2687 NC_008769.1 2944289 2944699 D hypothetical protein 2944289..2944699 Mycobacterium bovis BCG str. Pasteur 1173P2 4696721 YP_978774.1 CDS BCG_2688c NC_008769.1 2944767 2945519 R hypothetical protein complement(2944767..2945519) Mycobacterium bovis BCG str. Pasteur 1173P2 4699157 YP_978775.1 CDS BCG_2689c NC_008769.1 2945516 2946211 R hypothetical protein complement(2945516..2946211) Mycobacterium bovis BCG str. Pasteur 1173P2 4698800 YP_978776.1 CDS hemY NC_008769.1 2946217 2947575 R catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX; protoporphyrinogen oxidase complement(2946217..2947575) Mycobacterium bovis BCG str. Pasteur 1173P2 4699229 YP_978777.1 CDS hemE NC_008769.1 2947572 2948645 R catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase complement(2947572..2948645) Mycobacterium bovis BCG str. Pasteur 1173P2 4698931 YP_978778.1 CDS BCG_2692 NC_008769.1 2948698 2949528 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2948698..2949528 Mycobacterium bovis BCG str. Pasteur 1173P2 4698904 YP_978779.1 CDS BCG_2693 NC_008769.1 2949790 2950422 D hypothetical protein 2949790..2950422 Mycobacterium bovis BCG str. Pasteur 1173P2 4698749 YP_978780.1 CDS BCG_2694 NC_008769.1 2950424 2951740 D Differs from Rv2681 by 1aa V196A; hypothetical protein 2950424..2951740 Mycobacterium bovis BCG str. Pasteur 1173P2 4699141 YP_978781.1 CDS dxs1 NC_008769.1 2951737 2953653 R catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase complement(2951737..2953653) Mycobacterium bovis BCG str. Pasteur 1173P2 4699174 YP_978782.1 CDS BCG_2696 NC_008769.1 2953797 2954294 D Differs from Rv2683 by 1aa, S84L; hypothetical protein 2953797..2954294 Mycobacterium bovis BCG str. Pasteur 1173P2 4696473 YP_978783.1 CDS arsA NC_008769.1 2954299 2955588 D arsenic-transport integral membrane protein arsA 2954299..2955588 Mycobacterium bovis BCG str. Pasteur 1173P2 4698992 YP_978784.1 CDS arsB1 NC_008769.1 2955668 2956954 D Differs from Rv2685 by 1aa, G378A and Mb2704, by 1aa, G393C; arsenic-transport integral membrane protein arsB1 2955668..2956954 Mycobacterium bovis BCG str. Pasteur 1173P2 4696729 YP_978785.1 CDS BCG_2699c NC_008769.1 2956965 2957723 R antibiotic ABC transporter integral membrane protein complement(2956965..2957723) Mycobacterium bovis BCG str. Pasteur 1173P2 4695346 YP_978786.1 CDS BCG_2700c NC_008769.1 2957720 2958433 R antibiotic ABC transporter integral membrane protein complement(2957720..2958433) Mycobacterium bovis BCG str. Pasteur 1173P2 4698704 YP_978787.1 CDS BCG_2701c NC_008769.1 2958430 2959335 R Differs from Rv2688c by 1aa, T156P; antibiotic-transport ATP-binding protein ABC transporter complement(2958430..2959335) Mycobacterium bovis BCG str. Pasteur 1173P2 4698672 YP_978788.1 CDS BCG_2702c NC_008769.1 2959530 2960747 R hypothetical protein complement(2959530..2960747) Mycobacterium bovis BCG str. Pasteur 1173P2 4697977 YP_978789.1 CDS BCG_2703c NC_008769.1 2960903 2962894 R In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a single base transition (t-c) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (663 aa versus 657 aa); integral membrane alanine and valine and leucine rich protein complement(2960903..2962894) Mycobacterium bovis BCG str. Pasteur 1173P2 4698248 YP_978790.1 CDS ceoB NC_008769.1 2963029 2963712 D Differs from Rv2691 by 1aa, A117T; TRK system potassium uptake protein ceoB 2963029..2963712 Mycobacterium bovis BCG str. Pasteur 1173P2 4699242 YP_978791.1 CDS ceoC NC_008769.1 2963709 2964371 D Differs from Rv2692 by 1aa, V133I; TRK system potassium uptake protein ceoC 2963709..2964371 Mycobacterium bovis BCG str. Pasteur 1173P2 4697668 YP_978792.1 CDS BCG_2706c NC_008769.1 2964382 2965053 R integral membrane alanine and leucine rich protein complement(2964382..2965053) Mycobacterium bovis BCG str. Pasteur 1173P2 4698048 YP_978793.1 CDS BCG_2707c NC_008769.1 2965084 2965452 R Differs from Rv2694c by 1aa, S68R; hypothetical protein complement(2965084..2965452) Mycobacterium bovis BCG str. Pasteur 1173P2 4699234 YP_978794.1 CDS BCG_2708 NC_008769.1 2965601 2966308 D hypothetical protein 2965601..2966308 Mycobacterium bovis BCG str. Pasteur 1173P2 4698249 YP_978795.1 CDS BCG_2709c NC_008769.1 2966514 2967293 R Differs from Rv2696c by 1aa, N164D; hypothetical protein complement(2966514..2967293) Mycobacterium bovis BCG str. Pasteur 1173P2 4698557 YP_978796.1 CDS dut NC_008769.1 2967368 2967832 R catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase complement(2967368..2967832) Mycobacterium bovis BCG str. Pasteur 1173P2 4698537 YP_978797.1 CDS BCG_2711 NC_008769.1 2967858 2968343 D alanine rich transmembrane protein 2967858..2968343 Mycobacterium bovis BCG str. Pasteur 1173P2 4696429 YP_978798.1 CDS BCG_2712c NC_008769.1 2968348 2968650 R hypothetical protein complement(2968348..2968650) Mycobacterium bovis BCG str. Pasteur 1173P2 4698626 YP_978799.1 CDS BCG_2713 NC_008769.1 2968888 2969538 D hypothetical protein 2968888..2969538 Mycobacterium bovis BCG str. Pasteur 1173P2 4699231 YP_978800.1 CDS suhB NC_008769.1 2969548 2970420 R extragenic suppressor protein suhB complement(2969548..2970420) Mycobacterium bovis BCG str. Pasteur 1173P2 4698883 YP_978801.1 CDS ppgK NC_008769.1 2970543 2971340 D Differs from Rv2702 by 1aa, T203I; polyphosphate glucokinase ppgK 2970543..2971340 Mycobacterium bovis BCG str. Pasteur 1173P2 4696336 YP_978802.1 CDS sigA NC_008769.1 2971520 2973106 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RNA polymerase sigma factor 2971520..2973106 Mycobacterium bovis BCG str. Pasteur 1173P2 4696419 YP_978803.1 CDS BCG_2717 NC_008769.1 2973143 2973571 D hypothetical protein 2973143..2973571 Mycobacterium bovis BCG str. Pasteur 1173P2 4696253 YP_978804.1 CDS BCG_2718c NC_008769.1 2973499 2973888 R hypothetical protein complement(2973499..2973888) Mycobacterium bovis BCG str. Pasteur 1173P2 4698893 YP_978805.1 CDS BCG_2719c NC_008769.1 2973885 2974142 R hypothetical protein complement(2973885..2974142) Mycobacterium bovis BCG str. Pasteur 1173P2 4696898 YP_978806.1 CDS BCG_2720 NC_008769.1 2974258 2975232 D transmembrane alanine and leucine rich protein 2974258..2975232 Mycobacterium bovis BCG str. Pasteur 1173P2 4698925 YP_978807.1 CDS BCG_2721c NC_008769.1 2975233 2975481 R hypothetical protein complement(2975233..2975481) Mycobacterium bovis BCG str. Pasteur 1173P2 4698926 YP_978808.1 CDS BCG_2722 NC_008769.1 2975524 2975970 D Differs from Rv2709 by 1aa, S35T; hypothetical protein 2975524..2975970 Mycobacterium bovis BCG str. Pasteur 1173P2 4698946 YP_978809.1 CDS sigB NC_008769.1 2976146 2977117 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase; RNA polymerase sigma factor SigB 2976146..2977117 Mycobacterium bovis BCG str. Pasteur 1173P2 4698951 YP_978810.1 CDS ideR NC_008769.1 2977250 2977942 D Iron-dependent repressor and activator ideR 2977250..2977942 Mycobacterium bovis BCG str. Pasteur 1173P2 4695814 YP_978811.1 CDS BCG_2725c NC_008769.1 2977955 2979013 R hypothetical protein complement(2977955..2979013) Mycobacterium bovis BCG str. Pasteur 1173P2 4699216 YP_978812.1 CDS sthA NC_008769.1 2979126 2980532 D catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 2979126..2980532 Mycobacterium bovis BCG str. Pasteur 1173P2 4698960 YP_978813.1 CDS BCG_2727 NC_008769.1 2980750 2981724 D Differs from Rv2714 by 2aa, W181S, A245V; hypothetical protein 2980750..2981724 Mycobacterium bovis BCG str. Pasteur 1173P2 4696756 YP_978814.1 CDS BCG_2728 NC_008769.1 2981783 2982808 D hydrolase 2981783..2982808 Mycobacterium bovis BCG str. Pasteur 1173P2 4698958 YP_978815.1 CDS BCG_2729 NC_008769.1 2982857 2983543 D hypothetical protein 2982857..2983543 Mycobacterium bovis BCG str. Pasteur 1173P2 4698956 YP_978816.1 CDS BCG_2730c NC_008769.1 2983552 2984046 R hypothetical protein complement(2983552..2984046) Mycobacterium bovis BCG str. Pasteur 1173P2 4698943 YP_978817.1 CDS nrdR NC_008769.1 2984098 2984562 R transcriptional regulator NrdR complement(2984098..2984562) Mycobacterium bovis BCG str. Pasteur 1173P2 4698966 YP_978818.1 CDS BCG_2732c NC_008769.1 2984725 2985222 R Differs from Rv2719c by 1aa, H124Y; hypothetical protein complement(2984725..2985222) Mycobacterium bovis BCG str. Pasteur 1173P2 4698889 YP_978819.1 CDS lexA NC_008769.1 2985530 2986183 D Represses a number of genes involved in the response to DNA damage; LexA repressor 2985530..2986183 Mycobacterium bovis BCG str. Pasteur 1173P2 4698959 YP_978820.1 CDS BCG_2734c NC_008769.1 2986205 2988304 R Differs from Rv2721c and Mb2740c by 2aa, S251G, A326T; transmembrane alanine and glycine rich protein complement(2986205..2988304) Mycobacterium bovis BCG str. Pasteur 1173P2 4697486 YP_978821.1 CDS BCG_2735 NC_008769.1 2988320 2988568 D hypothetical protein 2988320..2988568 Mycobacterium bovis BCG str. Pasteur 1173P2 4698972 YP_978822.1 CDS BCG_2736 NC_008769.1 2988594 2989787 D integral membrane protein 2988594..2989787 Mycobacterium bovis BCG str. Pasteur 1173P2 4698967 YP_978823.1 CDS fadE20 NC_008769.1 2989816 2990976 R Differs from Rv2724c by 1aa, T127I, and from Mb2743c by 1aa, P33A; acyl-CoA dehydrogenase fadE20 complement(2989816..2990976) Mycobacterium bovis BCG str. Pasteur 1173P2 4698954 YP_978824.1 CDS hflX NC_008769.1 2991112 2992599 R Differs from Rv2725c and Mb2744c by 1aa, D218G; GTP-binding protein hflX complement(2991112..2992599) Mycobacterium bovis BCG str. Pasteur 1173P2 4699119 YP_978825.1 CDS dapF NC_008769.1 2992616 2993485 R involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase complement(2992616..2993485) Mycobacterium bovis BCG str. Pasteur 1173P2 4698933 YP_978826.1 CDS miaA NC_008769.1 2993510 2994454 R IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase complement(2993510..2994454) Mycobacterium bovis BCG str. Pasteur 1173P2 4697823 YP_978827.1 CDS BCG_2741c NC_008769.1 2994451 2995146 R hypothetical protein complement(2994451..2995146) Mycobacterium bovis BCG str. Pasteur 1173P2 4699002 YP_978828.1 CDS BCG_2742c NC_008769.1 2995255 2996160 R Differs from Rv2729c by 3aa, L41F, E202A, V266A; integral membrane alanine and valine and leucine rich protein complement(2995255..2996160) Mycobacterium bovis BCG str. Pasteur 1173P2 4697967 YP_978829.1 CDS BCG_2743 NC_008769.1 2996227 2996703 D hypothetical protein 2996227..2996703 Mycobacterium bovis BCG str. Pasteur 1173P2 4698982 YP_978830.1 CDS BCG_2744 NC_008769.1 2996711 2998063 D hypothetical protein 2996711..2998063 Mycobacterium bovis BCG str. Pasteur 1173P2 4698986 YP_978831.1 CDS BCG_2745c NC_008769.1 2998060 2998674 R hypothetical protein complement(2998060..2998674) Mycobacterium bovis BCG str. Pasteur 1173P2 4698997 YP_978832.1 CDS BCG_2746c NC_008769.1 2998671 3000209 R catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase complement(2998671..3000209) Mycobacterium bovis BCG str. Pasteur 1173P2 4698995 YP_978833.1 CDS BCG_2747 NC_008769.1 3000506 3001360 D hypothetical protein 3000506..3001360 Mycobacterium bovis BCG str. Pasteur 1173P2 4699013 YP_978834.1 CDS BCG_2748c NC_008769.1 3001245 3002237 R hypothetical protein complement(3001245..3002237) Mycobacterium bovis BCG str. Pasteur 1173P2 4698998 YP_978835.1 CDS recX NC_008769.1 3002247 3002771 R binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX complement(3002247..3002771) Mycobacterium bovis BCG str. Pasteur 1173P2 4699027 YP_978836.1 CDS recA NC_008769.1 3002737 3005109 R these RecA proteins contain inteins; catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; DNA recombination protein RecA complement(3002737..3005109) Mycobacterium bovis BCG str. Pasteur 1173P2 4695841 YP_978837.1 CDS BCG_2751 NC_008769.1 3005304 3005477 D hypothetical protein 3005304..3005477 Mycobacterium bovis BCG str. Pasteur 1173P2 4697309 YP_978838.1 CDS BCG_2752c NC_008769.1 3005491 3005697 R hypothetical protein complement(3005491..3005697) Mycobacterium bovis BCG str. Pasteur 1173P2 4699018 YP_978839.1 CDS BCG_2753c NC_008769.1 3005708 3006874 R alanine rich transferase complement(3005708..3006874) Mycobacterium bovis BCG str. Pasteur 1173P2 4699026 YP_978840.1 CDS ephG NC_008769.1 3006918 3007367 D epoxide hydrolase 3006918..3007367 Mycobacterium bovis BCG str. Pasteur 1173P2 4699034 YP_978842.1 CDS PE_PGRS47 NC_008769.1 3007643 3008917 D In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, deletions of a single base (t-*) and of 84 bp (H37Rv2.3054724-3054807-*) leads to a shorter product with a different 5' start compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Also has lost 174 bp compared to Mb2761; PE-PGRS family protein 3007643..3008917 Mycobacterium bovis BCG str. Pasteur 1173P2 4695669 YP_978843.1 CDS BCG_2757c NC_008769.1 3008941 3009189 R In Mycobacterium tuberculosis strain H37Rv, Rv2742c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a 23 bp insertion splits Rv2742c into two parts; hypothetical protein complement(3008941..3009189) Mycobacterium bovis BCG str. Pasteur 1173P2 4695668 YP_978844.1 CDS BCG_2758c NC_008769.1 3009210 3009797 R In Mycobacterium tuberculosis strain H37Rv, Rv2742c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a 23 bp insertion splits Rv2742c into two parts; hypothetical protein complement(3009210..3009797) Mycobacterium bovis BCG str. Pasteur 1173P2 4697969 YP_978845.1 CDS BCG_2759c NC_008769.1 3009869 3010681 R membrane alanine rich protein complement(3009869..3010681) Mycobacterium bovis BCG str. Pasteur 1173P2 4699035 YP_978846.1 CDS 35kd_ag NC_008769.1 3010700 3011512 R Differs from Mb2765c by 1aa, K153Q; hypothetical protein complement(3010700..3011512) Mycobacterium bovis BCG str. Pasteur 1173P2 4699045 YP_978847.1 CDS BCG_2761c NC_008769.1 3011642 3011980 R transcriptional regulatory protein complement(3011642..3011980) Mycobacterium bovis BCG str. Pasteur 1173P2 4698659 YP_978848.1 CDS pgsA3 NC_008769.1 3012051 3012680 R pgp synthase pgsA3 complement(3012051..3012680) Mycobacterium bovis BCG str. Pasteur 1173P2 4699038 YP_978849.1 CDS BCG_2763 NC_008769.1 3012711 3013235 D catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis; N-acetylglutamate synthase 3012711..3013235 Mycobacterium bovis BCG str. Pasteur 1173P2 4698858 YP_978850.1 CDS ftsK NC_008769.1 3013304 3015955 R cell division transmembrane protein ftsK complement(3013304..3015955) Mycobacterium bovis BCG str. Pasteur 1173P2 4699047 YP_978851.1 CDS BCG_2765 NC_008769.1 3015954 3016268 D hypothetical protein 3015954..3016268 Mycobacterium bovis BCG str. Pasteur 1173P2 4695823 YP_978852.1 CDS BCG_2766 NC_008769.1 3016265 3017083 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 3016265..3017083 Mycobacterium bovis BCG str. Pasteur 1173P2 4699055 YP_978853.1 CDS BCG_2767 NC_008769.1 3017087 3017977 D hypothetical protein 3017087..3017977 Mycobacterium bovis BCG str. Pasteur 1173P2 4699028 YP_978854.1 CDS BCG_2768c NC_008769.1 3017964 3019640 R hypothetical protein complement(3017964..3019640) Mycobacterium bovis BCG str. Pasteur 1173P2 4698452 YP_978855.1 CDS dapA NC_008769.1 3019671 3020573 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(3019671..3020573) Mycobacterium bovis BCG str. Pasteur 1173P2 4699062 YP_978856.1 CDS thyX NC_008769.1 3020642 3021394 R flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase complement(3020642..3021394) Mycobacterium bovis BCG str. Pasteur 1173P2 4697475 YP_978857.1 CDS hsdS' NC_008769.1 3021638 3021913 R type I restriction/modification system specificity determinant hsdS' complement(3021638..3021913) Mycobacterium bovis BCG str. Pasteur 1173P2 4699070 YP_978858.1 CDS hsdM NC_008769.1 3021910 3023532 R Differs from Rv2756c by 1aa, P306L; type I restriction/modification system DNA methylase hsdM complement(3021910..3023532) Mycobacterium bovis BCG str. Pasteur 1173P2 4697338 YP_978859.1 CDS BCG_2773c NC_008769.1 3023619 3024035 R hypothetical protein complement(3023619..3024035) Mycobacterium bovis BCG str. Pasteur 1173P2 4697336 YP_978860.1 CDS BCG_2774c NC_008769.1 3024032 3024298 R hypothetical protein complement(3024032..3024298) Mycobacterium bovis BCG str. Pasteur 1173P2 4699066 YP_978861.1 CDS BCG_2775c NC_008769.1 3024324 3024719 R hypothetical protein complement(3024324..3024719) Mycobacterium bovis BCG str. Pasteur 1173P2 4699081 YP_978862.1 CDS BCG_2776c NC_008769.1 3024716 3024985 R hypothetical protein complement(3024716..3024985) Mycobacterium bovis BCG str. Pasteur 1173P2 4698473 YP_978863.1 CDS hsdS NC_008769.1 3024995 3026089 R type I restriction/modification system specificity determinant hsdS complement(3024995..3026089) Mycobacterium bovis BCG str. Pasteur 1173P2 4699082 YP_978864.1 CDS BCG_2778c NC_008769.1 3026086 3026358 R In Mycobacterium tuberculosis strain H37Rv, Rv2762c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transition (c-t) splits Rv2762c into 2 parts; hypothetical protein complement(3026086..3026358) Mycobacterium bovis BCG str. Pasteur 1173P2 4697337 YP_978865.1 CDS BCG_2779c NC_008769.1 3026374 3026505 R In Mycobacterium tuberculosis strain H37Rv, Rv2762c exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base transition (c-t) splits Rv2762c into 2 parts; hypothetical protein complement(3026374..3026505) Mycobacterium bovis BCG str. Pasteur 1173P2 4699073 YP_978866.1 CDS dfrA NC_008769.1 3026579 3027058 R dihydrofolate reductase dfrA complement(3026579..3027058) Mycobacterium bovis BCG str. Pasteur 1173P2 4699078 YP_978867.1 CDS thyA NC_008769.1 3027129 3027920 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(3027129..3027920) Mycobacterium bovis BCG str. Pasteur 1173P2 4697134 YP_978868.1 CDS BCG_2782 NC_008769.1 3028085 3028822 D Differs from Rv2765 and Mb2787 by 1aa, I129M; alanine rich hydrolase 3028085..3028822 Mycobacterium bovis BCG str. Pasteur 1173P2 4695911 YP_978869.1 CDS fabG NC_008769.1 3029037 3029819 R Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(3029037..3029819) Mycobacterium bovis BCG str. Pasteur 1173P2 4699091 YP_978870.1 CDS BCG_2784c NC_008769.1 3029816 3030169 R Differs from Rv2767c and Mb2789c by 1aa, L26S; hypothetical protein complement(3029816..3030169) Mycobacterium bovis BCG str. Pasteur 1173P2 4699094 YP_978871.1 CDS PPE43 NC_008769.1 3030343 3031527 R Differs from Rv2768c by 1aa, R263P; PPE family protein complement(3030343..3031527) Mycobacterium bovis BCG str. Pasteur 1173P2 4699080 YP_978872.1 CDS PE27 NC_008769.1 3031607 3032434 R Differs from Rv2769c by 2aa, S54P, M270V; PE family protein complement(3031607..3032434) Mycobacterium bovis BCG str. Pasteur 1173P2 4697821 YP_978873.1 CDS PPE44 NC_008769.1 3032758 3033906 R Differs from Rv2770c by 1aa, S194F; PPE family protein complement(3032758..3033906) Mycobacterium bovis BCG str. Pasteur 1173P2 4697127 YP_978874.1 CDS BCG_2788c NC_008769.1 3034030 3034482 R Differs from Rv2771c by 1aa, P80L; hypothetical protein complement(3034030..3034482) Mycobacterium bovis BCG str. Pasteur 1173P2 4697822 YP_978875.1 CDS BCG_2789c NC_008769.1 3034568 3035041 R hypothetical protein complement(3034568..3035041) Mycobacterium bovis BCG str. Pasteur 1173P2 4699069 YP_978876.1 CDS dapB NC_008769.1 3035053 3035790 R catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase complement(3035053..3035790) Mycobacterium bovis BCG str. Pasteur 1173P2 4699108 YP_978877.1 CDS BCG_2791c NC_008769.1 3035801 3036205 R hypothetical protein complement(3035801..3036205) Mycobacterium bovis BCG str. Pasteur 1173P2 4696260 YP_978878.1 CDS BCG_2792 NC_008769.1 3036358 3036819 D hypothetical protein 3036358..3036819 Mycobacterium bovis BCG str. Pasteur 1173P2 4699130 YP_978879.1 CDS BCG_2793c NC_008769.1 3036823 3037752 R oxidoreductase complement(3036823..3037752) Mycobacterium bovis BCG str. Pasteur 1173P2 4699086 YP_978880.1 CDS BCG_2794c NC_008769.1 3037934 3039004 R hypothetical protein complement(3037934..3039004) Mycobacterium bovis BCG str. Pasteur 1173P2 4699146 YP_978881.1 CDS BCG_2795c NC_008769.1 3039162 3039632 R hypothetical protein complement(3039162..3039632) Mycobacterium bovis BCG str. Pasteur 1173P2 4699159 YP_978882.1 CDS BCG_2796c NC_008769.1 3039664 3040203 R In Mycobacterium bovis, a 24 bp deletion leads to a shorter product compared to its homolog in Mycobacterium bovis BCG Pasteur, and Mycobacterium tuberculosis strain H37Rv (171 aa versus 179 aa); Differs from Rv2779c by 1aa, I9M, and 8 aa longer than Mb2801c; lrp/asnC family transcriptional regulator complement(3039664..3040203) Mycobacterium bovis BCG str. Pasteur 1173P2 4699140 YP_978883.1 CDS ald_a NC_008769.1 3040269 3040667 D In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis BCG Pasteur, and in Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits ald into 2 parts, ald_a and aldb; L-alanine dehydrogenase 3040269..3040667 Mycobacterium bovis BCG str. Pasteur 1173P2 4699143 YP_978884.1 CDS aldb NC_008769.1 3040664 3041383 D In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis BCG Pasteur, and in Mycobacterium bovis, a frameshift due to a single base deletion (a-*) splits ald into 2 parts, ald_a and aldb; L-alanine dehydrogenase 3040664..3041383 Mycobacterium bovis BCG str. Pasteur 1173P2 4696993 YP_978885.1 CDS BCG_2799c NC_008769.1 3041398 3042432 R alanine rich oxidoreductase complement(3041398..3042432) Mycobacterium bovis BCG str. Pasteur 1173P2 4696662 YP_978886.1 CDS pepR NC_008769.1 3042493 3043809 R zinc protease pepR complement(3042493..3043809) Mycobacterium bovis BCG str. Pasteur 1173P2 4699147 YP_978887.1 CDS gpsI NC_008769.1 3043787 3046045 R polynucleotide phosphorylase complement(3043787..3046045) Mycobacterium bovis BCG str. Pasteur 1173P2 4696295 YP_978888.1 CDS lppU NC_008769.1 3046399 3046914 R hypothetical protein complement(3046399..3046914) Mycobacterium bovis BCG str. Pasteur 1173P2 4697843 YP_978889.1 CDS rpsO NC_008769.1 3046927 3047196 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(3046927..3047196) Mycobacterium bovis BCG str. Pasteur 1173P2 4698578 YP_978890.1 CDS ribF NC_008769.1 3047353 3048348 R catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase complement(3047353..3048348) Mycobacterium bovis BCG str. Pasteur 1173P2 4698853 YP_978891.1 CDS BCG_2805 NC_008769.1 3048559 3050322 D Differs from Rv2787 and Mb2810 by 1aa, P78T; hypothetical protein 3048559..3050322 Mycobacterium bovis BCG str. Pasteur 1173P2 4695901 YP_978892.1 CDS sirR NC_008769.1 3050407 3051093 D Differs from Rv2788 by 1aa, A137D; transcriptional repressor sirR 3050407..3051093 Mycobacterium bovis BCG str. Pasteur 1173P2 4699165 YP_978893.1 CDS fadE21 NC_008769.1 3051154 3052386 R acyl-CoA dehydrogenase fadE21 complement(3051154..3052386) Mycobacterium bovis BCG str. Pasteur 1173P2 4697290 YP_978894.1 CDS ltp1 NC_008769.1 3052412 3053617 R lipid-transfer protein complement(3052412..3053617) Mycobacterium bovis BCG str. Pasteur 1173P2 4699120 YP_978895.1 CDS BCG_2809c NC_008769.1 3053650 3055029 R transposase complement(3053650..3055029) Mycobacterium bovis BCG str. Pasteur 1173P2 4697261 YP_978896.1 CDS BCG_2810c NC_008769.1 3055029 3055610 R Differs from Mb2815c by 2aa, A17V, T80E; resolvase complement(3055029..3055610) Mycobacterium bovis BCG str. Pasteur 1173P2 4699162 YP_978897.1 CDS truB NC_008769.1 3055812 3056708 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(3055812..3056708) Mycobacterium bovis BCG str. Pasteur 1173P2 4699176 YP_978898.1 CDS BCG_2812c NC_008769.1 3056705 3057388 R Differs from Rv2794c by 1aa, V87M; hypothetical protein complement(3056705..3057388) Mycobacterium bovis BCG str. Pasteur 1173P2 4696830 YP_978899.1 CDS BCG_2813c NC_008769.1 3057385 3058359 R hypothetical protein complement(3057385..3058359) Mycobacterium bovis BCG str. Pasteur 1173P2 4699170 YP_978900.1 CDS lppV NC_008769.1 3058504 3059067 R Differs from Rv2796c by 1aa, F159C; lipoprotein lppV complement(3058504..3059067) Mycobacterium bovis BCG str. Pasteur 1173P2 4699177 YP_978901.1 CDS BCG_2815c NC_008769.1 3059067 3060755 R hypothetical protein complement(3059067..3060755) Mycobacterium bovis BCG str. Pasteur 1173P2 4698579 YP_978902.1 CDS BCG_2816c NC_008769.1 3060759 3061085 R hypothetical protein complement(3060759..3061085) Mycobacterium bovis BCG str. Pasteur 1173P2 4699178 YP_978903.1 CDS BCG_2817 NC_008769.1 3061216 3061845 D In Mycobacterium bovis, a 3 bp insertion (*-ggt) leads to a slightly longer product compared to its homolog in Mycobacterium bovis BCG Pasteur and Mycobacterium tuberculosis strain H37Rv (210 aa versus 209 aa); hypothetical protein 3061216..3061845 Mycobacterium bovis BCG str. Pasteur 1173P2 4699181 YP_978904.1 CDS BCG_2818 NC_008769.1 3061864 3063513 D hydrolase 3061864..3063513 Mycobacterium bovis BCG str. Pasteur 1173P2 4699190 YP_978905.1 CDS BCG_2819c NC_008769.1 3063615 3063971 R hypothetical protein complement(3063615..3063971) Mycobacterium bovis BCG str. Pasteur 1173P2 4699172 YP_978906.1 CDS BCG_2820c NC_008769.1 3064228 3065271 R hypothetical protein complement(3064228..3065271) Mycobacterium bovis BCG str. Pasteur 1173P2 4699167 YP_978907.1 CDS BCG_2821 NC_008769.1 3065270 3065737 D hypothetical protein 3065270..3065737 Mycobacterium bovis BCG str. Pasteur 1173P2 4698955 YP_978908.1 CDS BCG_2822c NC_008769.1 3065913 3066542 R Differs from Rv2804c by 2aa, T58A, V74A; hypothetical protein complement(3065913..3066542) Mycobacterium bovis BCG str. Pasteur 1173P2 4698106 YP_978909.1 CDS BCG_2823 NC_008769.1 3066315 3066719 D Differs from Rv2805 by 1aa, D4G; hypothetical protein 3066315..3066719 Mycobacterium bovis BCG str. Pasteur 1173P2 4699197 YP_978910.1 CDS BCG_2824 NC_008769.1 3066716 3066907 D hypothetical protein 3066716..3066907 Mycobacterium bovis BCG str. Pasteur 1173P2 4699208 YP_978911.1 CDS BCG_2825 NC_008769.1 3067106 3068260 D Differs from Rv2807 by 2aa, V72E, T349M, and from Mb2830 by 1aa, T349M; hypothetical protein 3067106..3068260 Mycobacterium bovis BCG str. Pasteur 1173P2 4699233 YP_978912.1 CDS BCG_2826 NC_008769.1 3068494 3068751 D hypothetical protein 3068494..3068751 Mycobacterium bovis BCG str. Pasteur 1173P2 4699223 YP_978913.1 CDS BCG_2827 NC_008769.1 3068856 3069167 D Differs from Rv2809 by 1aa, P46T; hypothetical protein 3068856..3069167 Mycobacterium bovis BCG str. Pasteur 1173P2 4699237 YP_978914.1 CDS BCG_2829 NC_008769.1 3069587 3070195 D hypothetical protein 3069587..3070195 Mycobacterium bovis BCG str. Pasteur 1173P2 4699270 YP_978915.1 CDS BCG_2830 NC_008769.1 3070266 3071675 D In Mycobacterium bovis BCG Pasteur and in Mycobacterium tuberculosis strain H37Rv, Rv2812 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (tg-*) splits Rv2812 into 2 parts, Mb2835 and Mb2836. Differs from Rv2812 by 1 aa, G395R; transposase 3070266..3071675 Mycobacterium bovis BCG str. Pasteur 1173P2 4699261 YP_978916.1 CDS BCG_2831 NC_008769.1 3071672 3072484 D Differs from Rv2813 by 1aa, V76I; hypothetical protein 3071672..3072484 Mycobacterium bovis BCG str. Pasteur 1173P2 4699263 YP_978917.1 CDS BCG_2832c NC_008769.1 3074087 3074923 R transposase complement(3074087..3074923) Mycobacterium bovis BCG str. Pasteur 1173P2 4699244 YP_978918.1 CDS BCG_2833c NC_008769.1 3075022 3075348 R transposase complement(3075022..3075348) Mycobacterium bovis BCG str. Pasteur 1173P2 4699271 YP_978919.1 CDS BCG_2834c NC_008769.1 3077602 3077943 R hypothetical protein complement(3077602..3077943) Mycobacterium bovis BCG str. Pasteur 1173P2 4699257 YP_978920.1 CDS BCG_2835c NC_008769.1 3077944 3078960 R hypothetical protein complement(3077944..3078960) Mycobacterium bovis BCG str. Pasteur 1173P2 4695859 YP_978921.1 CDS BCG_2837c NC_008769.1 3079210 3080220 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transition (c-t) introduces a premature stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (336 aa versus 382 aa); hypothetical protein complement(3079210..3080220) Mycobacterium bovis BCG str. Pasteur 1173P2 4698069 YP_978922.1 CDS BCG_2838c NC_008769.1 3080217 3081344 R hypothetical protein complement(3080217..3081344) Mycobacterium bovis BCG str. Pasteur 1173P2 4698363 YP_978923.1 CDS BCG_2839c NC_008769.1 3081341 3082249 R hypothetical protein complement(3081341..3082249) Mycobacterium bovis BCG str. Pasteur 1173P2 4698091 YP_978924.1 CDS BCG_2840c NC_008769.1 3082230 3082940 R hypothetical protein complement(3082230..3082940) Mycobacterium bovis BCG str. Pasteur 1173P2 4698470 YP_978925.1 CDS BCG_2841c NC_008769.1 3082950 3083324 R hypothetical protein complement(3082950..3083324) Mycobacterium bovis BCG str. Pasteur 1173P2 4698757 YP_978926.1 CDS BCG_2842c NC_008769.1 3083321 3085759 R In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 9 bp insertion (*-cggcgatgt) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv; hypothetical protein complement(3083321..3085759) Mycobacterium bovis BCG str. Pasteur 1173P2 4699158 YP_978927.1 CDS BCG_2843c NC_008769.1 3085756 3086700 R Differs from Mb2848c by 1aa H56P; hypothetical protein complement(3085756..3086700) Mycobacterium bovis BCG str. Pasteur 1173P2 4698051 YP_978928.1 CDS BCG_2844c NC_008769.1 3086878 3087525 R Differs from Rv2825c by 5aa, E2K, C162S, L189V, Q192T, E195A; hypothetical protein complement(3086878..3087525) Mycobacterium bovis BCG str. Pasteur 1173P2 4698523 YP_978929.1 CDS BCG_2845c NC_008769.1 3087695 3088579 R hypothetical protein complement(3087695..3088579) Mycobacterium bovis BCG str. Pasteur 1173P2 4698411 YP_978930.1 CDS BCG_2846c NC_008769.1 3088582 3089469 R hypothetical protein complement(3088582..3089469) Mycobacterium bovis BCG str. Pasteur 1173P2 4698486 YP_978931.1 CDS BCG_2847c NC_008769.1 3089774 3090319 R Differs from Mb2852c by 1aa E58A; hypothetical protein complement(3089774..3090319) Mycobacterium bovis BCG str. Pasteur 1173P2 4698315 YP_978932.1 CDS BCG_2848c NC_008769.1 3090316 3090585 R hypothetical protein complement(3090316..3090585) Mycobacterium bovis BCG str. Pasteur 1173P2 4698227 YP_978933.1 CDS BCG_2849c NC_008769.1 3090606 3090998 R hypothetical protein complement(3090606..3090998) Mycobacterium bovis BCG str. Pasteur 1173P2 4698072 YP_978934.1 CDS BCG_2850c NC_008769.1 3090995 3091210 R Differs from Rv2830c by 1aa, V56A; hypothetical protein complement(3090995..3091210) Mycobacterium bovis BCG str. Pasteur 1173P2 4698184 YP_978935.1 CDS echA16 NC_008769.1 3091257 3092006 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 3091257..3092006 Mycobacterium bovis BCG str. Pasteur 1173P2 4698203 YP_978936.1 CDS ugpC NC_008769.1 3092085 3093167 R Differs from Rv2832c and Mb2856c by 1aa, L235F; sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter ugpC complement(3092085..3093167) Mycobacterium bovis BCG str. Pasteur 1173P2 4695716 YP_978937.1 CDS ugpBa NC_008769.1 3093838 3094470 R In mycobacterium bovis BCG Pasteur, a single base mutation (T->A) at corresponding position 3093840, in Mycobacterium tuberculosis H37Rv strain, leads to a stop codon and break ugpB in two parts. Differs from Rv2833c by 2aa, I111S, L174P; sn-glycerol-3-phosphate-binding lipoprotein ugpB complement(3093838..3094470) Mycobacterium bovis BCG str. Pasteur 1173P2 4697192 YP_978938.1 CDS ugpE NC_008769.1 3094473 3095300 R sn-glycerol-3-phosphate transport integral membrane protein ABC transporter ugpE complement(3094473..3095300) Mycobacterium bovis BCG str. Pasteur 1173P2 4697191 YP_978939.1 CDS ugpA NC_008769.1 3095297 3096208 R In Mycobacterium bovis BCG Pasteur and Mycobacterium tuberculosis strain H37Rv, ugpA exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) splits ugpA into 2 parts, ugpAa and ugpAb; sn-glycerol-3-phosphate transport integral membrane protein ABC transporter ugpA complement(3095297..3096208) Mycobacterium bovis BCG str. Pasteur 1173P2 4697194 YP_978940.1 CDS dinF NC_008769.1 3096295 3097614 R Differs from Rv2836c by 2aa, H157Q, L350P, and from Mb2861c by 1aa, H157Q; DNA-damage-inducible protein F dinF complement(3096295..3097614) Mycobacterium bovis BCG str. Pasteur 1173P2 4697190 YP_978941.1 CDS BCG_2857c NC_008769.1 3097621 3098631 R hypothetical protein complement(3097621..3098631) Mycobacterium bovis BCG str. Pasteur 1173P2 4695491 YP_978942.1 CDS rbfA NC_008769.1 3098606 3099157 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(3098606..3099157) Mycobacterium bovis BCG str. Pasteur 1173P2 4699316 YP_978943.1 CDS infB NC_008769.1 3099157 3101859 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(3099157..3101859) Mycobacterium bovis BCG str. Pasteur 1173P2 4697306 YP_978944.1 CDS BCG_2860c NC_008769.1 3101945 3102244 R hypothetical protein complement(3101945..3102244) Mycobacterium bovis BCG str. Pasteur 1173P2 4697074 YP_978945.1 CDS nusA NC_008769.1 3102371 3103414 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(3102371..3103414) Mycobacterium bovis BCG str. Pasteur 1173P2 4699059 YP_978946.1 CDS BCG_2862c NC_008769.1 3103411 3103962 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(3103411..3103962) Mycobacterium bovis BCG str. Pasteur 1173P2 4697205 YP_978947.1 CDS BCG_2863 NC_008769.1 3104157 3104702 D transmembrane alanine rich protein 3104157..3104702 Mycobacterium bovis BCG str. Pasteur 1173P2 4698608 YP_978948.1 CDS BCG_2864 NC_008769.1 3104699 3105187 D hypothetical protein 3104699..3105187 Mycobacterium bovis BCG str. Pasteur 1173P2 4698135 YP_978949.1 CDS proS NC_008769.1 3105188 3106936 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(3105188..3106936) Mycobacterium bovis BCG str. Pasteur 1173P2 4699164 YP_978950.1 CDS efpA NC_008769.1 3107025 3108617 R Differs from Rv2846c by 1aa, R15T; integral membrane efflux protein efpA complement(3107025..3108617) Mycobacterium bovis BCG str. Pasteur 1173P2 4696515 YP_978951.1 CDS cysG NC_008769.1 3108640 3109857 R multifunctional enzyme siroheme synthase cysG: uroporphyrin-III c-methyltransferase + precorrin-2 oxidase + ferrochelatase complement(3108640..3109857) Mycobacterium bovis BCG str. Pasteur 1173P2 4695779 YP_978952.1 CDS cobB NC_008769.1 3110134 3111507 R responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid; cobyrinic acid a,c-diamide synthase complement(3110134..3111507) Mycobacterium bovis BCG str. Pasteur 1173P2 4697918 YP_978953.1 CDS cobO NC_008769.1 3111507 3112130 R catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase complement(3111507..3112130) Mycobacterium bovis BCG str. Pasteur 1173P2 4698658 YP_978954.1 CDS BCG_2870c NC_008769.1 3112151 3114040 R Differs from Rv2850c by 2aa, Q273R, S446G; magnesium chelatase complement(3112151..3114040) Mycobacterium bovis BCG str. Pasteur 1173P2 4697938 YP_978955.1 CDS BCG_2871c NC_008769.1 3114037 3114507 R hypothetical protein complement(3114037..3114507) Mycobacterium bovis BCG str. Pasteur 1173P2 4699370 YP_978956.1 CDS mqo NC_008769.1 3114566 3116047 R malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase complement(3114566..3116047) Mycobacterium bovis BCG str. Pasteur 1173P2 4698212 YP_978957.1 CDS PE_PGRS48 NC_008769.1 3116254 3118047 D Differs from Rv2853 by 3aa, N227K, G228R, D232G, and 18aa deletion, and from Mb2878 by 1aa, D184G, and same 18aa deletion; PE-PGRS family protein 3116254..3118047 Mycobacterium bovis BCG str. Pasteur 1173P2 4698095 YP_978958.1 CDS BCG_2874 NC_008769.1 3118084 3119124 D hypothetical protein 3118084..3119124 Mycobacterium bovis BCG str. Pasteur 1173P2 4695717 YP_978959.1 CDS mtr NC_008769.1 3119137 3120516 D catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide; mycothione reductase 3119137..3120516 Mycobacterium bovis BCG str. Pasteur 1173P2 4699358 YP_978960.1 CDS nicT NC_008769.1 3120616 3121734 D nickel-transport integral membrane protein nicT 3120616..3121734 Mycobacterium bovis BCG str. Pasteur 1173P2 4699148 YP_978961.1 CDS BCG_2877 NC_008769.1 3121800 3122132 D hypothetical protein 3121800..3122132 Mycobacterium bovis BCG str. Pasteur 1173P2 4699204 YP_978962.1 CDS BCG_2878 NC_008769.1 3122144 3122359 D hypothetical protein 3122144..3122359 Mycobacterium bovis BCG str. Pasteur 1173P2 4698219 YP_978963.1 CDS BCG_2879c NC_008769.1 3122515 3123291 R short chain dehydrogenase complement(3122515..3123291) Mycobacterium bovis BCG str. Pasteur 1173P2 4699235 YP_978964.1 CDS aldC NC_008769.1 3123288 3124655 R aldehyde dehydrogenase aldC complement(3123288..3124655) Mycobacterium bovis BCG str. Pasteur 1173P2 4698471 YP_978965.1 CDS BCG_2881c NC_008769.1 3124652 3125578 R amidotransferase complement(3124652..3125578) Mycobacterium bovis BCG str. Pasteur 1173P2 4696737 YP_978966.1 CDS glnA4 NC_008769.1 3125559 3126932 R glutamine synthetase complement(3125559..3126932) Mycobacterium bovis BCG str. Pasteur 1173P2 4698322 YP_978967.1 CDS mapB NC_008769.1 3127092 3127949 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential; methionine aminopeptidase complement(3127092..3127949) Mycobacterium bovis BCG str. Pasteur 1173P2 4696212 YP_978968.1 CDS BCG_2884c NC_008769.1 3127991 3128575 R Differs from Rv2862c by 2aa, P18R, R50C; hypothetical protein complement(3127991..3128575) Mycobacterium bovis BCG str. Pasteur 1173P2 4698662 YP_978969.1 CDS BCG_2885 NC_008769.1 3128924 3129304 D hypothetical protein 3128924..3129304 Mycobacterium bovis BCG str. Pasteur 1173P2 4699232 YP_978970.1 CDS BCG_2886c NC_008769.1 3129386 3131197 R penicillin-binding lipoprotein complement(3129386..3131197) Mycobacterium bovis BCG str. Pasteur 1173P2 4698222 YP_978971.1 CDS BCG_2887 NC_008769.1 3131469 3131750 D hypothetical protein 3131469..3131750 Mycobacterium bovis BCG str. Pasteur 1173P2 4699364 YP_978972.1 CDS BCG_2888 NC_008769.1 3131754 3132017 D hypothetical protein 3131754..3132017 Mycobacterium bovis BCG str. Pasteur 1173P2 4698477 YP_978973.1 CDS BCG_2889c NC_008769.1 3132390 3133244 R hypothetical protein complement(3132390..3133244) Mycobacterium bovis BCG str. Pasteur 1173P2 4698991 YP_978974.1 CDS ispG NC_008769.1 3133300 3134463 R catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(3133300..3134463) Mycobacterium bovis BCG str. Pasteur 1173P2 4699179 YP_978975.1 CDS BCG_2891c NC_008769.1 3134480 3135694 R Differs from Mb2894c by 1aa, T330A, and from Rv2869c by 2aa, F259V, T330A; hypothetical protein complement(3134480..3135694) Mycobacterium bovis BCG str. Pasteur 1173P2 4696530 YP_978976.1 CDS dxr NC_008769.1 3135702 3136943 R catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase complement(3135702..3136943) Mycobacterium bovis BCG str. Pasteur 1173P2 4698567 YP_978977.1 CDS BCG_2893 NC_008769.1 3137070 3137327 D hypothetical protein 3137070..3137327 Mycobacterium bovis BCG str. Pasteur 1173P2 4697006 YP_978978.1 CDS BCG_2894 NC_008769.1 3137314 3137757 D Differs from Rv2872 and Mb2897 by 1aa, T72A; hypothetical protein 3137314..3137757 Mycobacterium bovis BCG str. Pasteur 1173P2 4698899 YP_978979.1 CDS mpb83 NC_008769.1 3137837 3138499 D cell surface lipoprotein mpb83 3137837..3138499 Mycobacterium bovis BCG str. Pasteur 1173P2 4699266 YP_978980.1 CDS dipZ NC_008769.1 3138779 3140866 D Differs from Rv2874 by 1aa, D672Y; integral membrane C-type cytochrome biogenesis protein dipZ 3138779..3140866 Mycobacterium bovis BCG str. Pasteur 1173P2 4696125 YP_978981.1 CDS mpb70 NC_008769.1 3140962 3141543 D hypothetical protein 3140962..3141543 Mycobacterium bovis BCG str. Pasteur 1173P2 4696775 YP_978982.1 CDS BCG_2898 NC_008769.1 3141595 3141909 D Differs from Mb2901 by 1aa, D101G, and from Rv2876 by 2aa, R44W, D101G; hypothetical protein 3141595..3141909 Mycobacterium bovis BCG str. Pasteur 1173P2 4696124 YP_978983.1 CDS BCG_2899c NC_008769.1 3141940 3142803 R Differs from Rv2877c by 1aa, H35Y; integral membrane protein complement(3141940..3142803) Mycobacterium bovis BCG str. Pasteur 1173P2 4698224 YP_978984.1 CDS mpb53 NC_008769.1 3142808 3143329 R hypothetical protein complement(3142808..3143329) Mycobacterium bovis BCG str. Pasteur 1173P2 4699363 YP_978985.1 CDS BCG_2901c NC_008769.1 3143515 3144609 R 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N complement(3143515..3144609) Mycobacterium bovis BCG str. Pasteur 1173P2 4696123 YP_978986.1 CDS cdsA NC_008769.1 3144632 3145552 R integral membrane phosphatidate cytidylyltransferase cdsA complement(3144632..3145552) Mycobacterium bovis BCG str. Pasteur 1173P2 4698206 YP_978987.1 CDS frr NC_008769.1 3145575 3146132 R Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor complement(3145575..3146132) Mycobacterium bovis BCG str. Pasteur 1173P2 4697650 YP_978988.1 CDS pyrH NC_008769.1 3146304 3147089 R Catalyzes the phosphorylation of UMP to UDP; uridylate kinase complement(3146304..3147089) Mycobacterium bovis BCG str. Pasteur 1173P2 4695820 YP_978989.1 CDS BCG_2905 NC_008769.1 3147324 3148082 D transcriptional regulatory protein 3147324..3148082 Mycobacterium bovis BCG str. Pasteur 1173P2 4697787 YP_978990.1 CDS BCG_2906c NC_008769.1 3148161 3149480 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-c) leads to a truncation resulting in a shorter product compared to its homolog in Mycobacterium tuberculosis stain H37Rv (439 aa versus 460 aa); transposase complement(3148161..3149480) Mycobacterium bovis BCG str. Pasteur 1173P2 4698168 YP_978991.1 CDS BCG_2907c NC_008769.1 3149477 3150364 R resolvase complement(3149477..3150364) Mycobacterium bovis BCG str. Pasteur 1173P2 4699195 YP_978992.1 CDS BCG_2908 NC_008769.1 3150363 3150782 D transcriptional regulatory protein 3150363..3150782 Mycobacterium bovis BCG str. Pasteur 1173P2 4699283 YP_978993.1 CDS amiC NC_008769.1 3150796 3152217 R catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase complement(3150796..3152217) Mycobacterium bovis BCG str. Pasteur 1173P2 4698195 YP_978994.1 CDS tsf NC_008769.1 3152224 3153039 R EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts complement(3152224..3153039) Mycobacterium bovis BCG str. Pasteur 1173P2 4697868 YP_978995.1 CDS rpsB NC_008769.1 3153051 3153914 R one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 complement(3153051..3153914) Mycobacterium bovis BCG str. Pasteur 1173P2 4697089 YP_978996.1 CDS BCG_2912 NC_008769.1 3154198 3154947 D hypothetical protein 3154198..3154947 Mycobacterium bovis BCG str. Pasteur 1173P2 4697296 YP_978997.1 CDS PPE45 NC_008769.1 3154726 3155952 R PPE family protein complement(3154726..3155952) Mycobacterium bovis BCG str. Pasteur 1173P2 4698691 YP_978998.1 CDS BCG_2914 NC_008769.1 3156352 3157329 D oxidoreductase 3156352..3157329 Mycobacterium bovis BCG str. Pasteur 1173P2 4696405 YP_978999.1 CDS xerC NC_008769.1 3157326 3158222 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC complement(3157326..3158222) Mycobacterium bovis BCG str. Pasteur 1173P2 4698624 YP_979000.1 CDS viuB NC_008769.1 3158313 3159164 R mycobactin utilization protein viuB complement(3158313..3159164) Mycobacterium bovis BCG str. Pasteur 1173P2 4697554 YP_979001.1 CDS BCG_2917c NC_008769.1 3159197 3160366 R Differs from Rv2896c by 2aa, G57E, A153S; hypothetical protein complement(3159197..3160366) Mycobacterium bovis BCG str. Pasteur 1173P2 4697887 YP_979002.1 CDS BCG_2918c NC_008769.1 3160363 3161874 R hypothetical protein complement(3160363..3161874) Mycobacterium bovis BCG str. Pasteur 1173P2 4698275 YP_979003.1 CDS BCG_2919c NC_008769.1 3161874 3162260 R hypothetical protein complement(3161874..3162260) Mycobacterium bovis BCG str. Pasteur 1173P2 4698073 YP_979004.1 CDS fdhD NC_008769.1 3162508 3163338 R involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein complement(3162508..3163338) Mycobacterium bovis BCG str. Pasteur 1173P2 4698357 YP_979005.1 CDS fdhF NC_008769.1 3163338 3165677 R formate dehydrogenase H fdhF complement(3163338..3165677) Mycobacterium bovis BCG str. Pasteur 1173P2 4696524 YP_979006.1 CDS BCG_2922c NC_008769.1 3165735 3166040 R hypothetical protein complement(3165735..3166040) Mycobacterium bovis BCG str. Pasteur 1173P2 4696525 YP_979007.1 CDS rnhB NC_008769.1 3166094 3166888 R RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII complement(3166094..3166888) Mycobacterium bovis BCG str. Pasteur 1173P2 4698220 YP_979008.1 CDS lepB NC_008769.1 3166902 3167786 R Differs from Rv2903c by 1aa, N2564D; signal peptidase I lepB complement(3166902..3167786) Mycobacterium bovis BCG str. Pasteur 1173P2 4697608 YP_979009.1 CDS rplS NC_008769.1 3167844 3168185 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(3167844..3168185) Mycobacterium bovis BCG str. Pasteur 1173P2 4695957 YP_979010.1 CDS lppW NC_008769.1 3168560 3169504 D alanine rich lipoprotein lppW 3168560..3169504 Mycobacterium bovis BCG str. Pasteur 1173P2 4695879 YP_979011.1 CDS trmD NC_008769.1 3169597 3170289 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(3169597..3170289) Mycobacterium bovis BCG str. Pasteur 1173P2 4698580 YP_979012.1 CDS rimM NC_008769.1 3170293 3170823 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(3170293..3170823) Mycobacterium bovis BCG str. Pasteur 1173P2 4697329 YP_979013.1 CDS BCG_2929c NC_008769.1 3170837 3171079 R hypothetical protein complement(3170837..3171079) Mycobacterium bovis BCG str. Pasteur 1173P2 4695582 YP_979014.1 CDS rpsP NC_008769.1 3171087 3171575 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(3171087..3171575) Mycobacterium bovis BCG str. Pasteur 1173P2 4698383 YP_979015.1 CDS BCG_2931c NC_008769.1 3171759 3172202 R hypothetical protein complement(3171759..3172202) Mycobacterium bovis BCG str. Pasteur 1173P2 4695805 YP_979016.1 CDS dacB2 NC_008769.1 3172271 3173146 D D-alanyl-D-alanine carboxypeptidase 3172271..3173146 Mycobacterium bovis BCG str. Pasteur 1173P2 4699374 YP_979017.1 CDS BCG_2933c NC_008769.1 3173206 3173793 R TetR family transcriptional regulator complement(3173206..3173793) Mycobacterium bovis BCG str. Pasteur 1173P2 4695939 YP_979018.1 CDS BCG_2934c NC_008769.1 3173795 3175630 R D-amino acid aminohydrolase complement(3173795..3175630) Mycobacterium bovis BCG str. Pasteur 1173P2 4699357 YP_979019.1 CDS pknI NC_008769.1 3175699 3177456 R transmembrane serine/threonine-protein kinase I pknI complement(3175699..3177456) Mycobacterium bovis BCG str. Pasteur 1173P2 4699286 YP_979020.1 CDS BCG_2936c NC_008769.1 3177500 3178612 R hypothetical protein complement(3177500..3178612) Mycobacterium bovis BCG str. Pasteur 1173P2 4697524 YP_979021.1 CDS ffh NC_008769.1 3178640 3180217 R signal recognition particle protein ffh complement(3178640..3180217) Mycobacterium bovis BCG str. Pasteur 1173P2 4699180 YP_979022.1 CDS BCG_2938 NC_008769.1 3180295 3182175 D Differs from Rv2917 by 1aa, L594R; hypothetical protein 3180295..3182175 Mycobacterium bovis BCG str. Pasteur 1173P2 4695364 YP_979023.1 CDS glnD NC_008769.1 3182186 3184612 R catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; also involved in adenylylating and deadelnylyating GlnK; PII uridylyl-transferase complement(3182186..3184612) Mycobacterium bovis BCG str. Pasteur 1173P2 4698068 YP_979024.1 CDS glnB NC_008769.1 3184670 3185008 R nitrogen regulatory protein P-II glnB complement(3184670..3185008) Mycobacterium bovis BCG str. Pasteur 1173P2 4697945 YP_979025.1 CDS amt NC_008769.1 3185005 3186438 R ammonium-transport integral membrane protein amt complement(3185005..3186438) Mycobacterium bovis BCG str. Pasteur 1173P2 4697944 YP_979026.1 CDS ftsY NC_008769.1 3186915 3188183 R cell division protein ftsY complement(3186915..3188183) Mycobacterium bovis BCG str. Pasteur 1173P2 4698243 YP_979027.1 CDS smc NC_008769.1 3188233 3191850 R Differs from Rv2922c by 2aa, R364L, G698R; chromosome partition protein smc complement(3188233..3191850) Mycobacterium bovis BCG str. Pasteur 1173P2 4698534 YP_979028.1 CDS acyP NC_008769.1 3191862 3192143 R catalyzes the hydrolysis of acylphosphate; acylphosphatase complement(3191862..3192143) Mycobacterium bovis BCG str. Pasteur 1173P2 4697291 YP_979029.1 CDS BCG_2945c NC_008769.1 3192130 3192543 R hypothetical protein complement(3192130..3192543) Mycobacterium bovis BCG str. Pasteur 1173P2 4697487 YP_979030.1 CDS fpg NC_008769.1 3192645 3193514 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(3192645..3193514) Mycobacterium bovis BCG str. Pasteur 1173P2 4698820 YP_979031.1 CDS rnc NC_008769.1 3193818 3194540 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(3193818..3194540) Mycobacterium bovis BCG str. Pasteur 1173P2 4695630 YP_979032.1 CDS BCG_2948c NC_008769.1 3194537 3195160 R hypothetical protein complement(3194537..3195160) Mycobacterium bovis BCG str. Pasteur 1173P2 4697606 YP_979033.1 CDS BCG_2949c NC_008769.1 3195211 3195948 R hypothetical protein complement(3195211..3195948) Mycobacterium bovis BCG str. Pasteur 1173P2 4698455 YP_979034.1 CDS tesA NC_008769.1 3196187 3196972 D thioesterase tesA 3196187..3196972 Mycobacterium bovis BCG str. Pasteur 1173P2 4698552 YP_979035.1 CDS BCG_2951 NC_008769.1 3196959 3197270 D hypothetical protein 3196959..3197270 Mycobacterium bovis BCG str. Pasteur 1173P2 4696849 YP_979036.1 CDS fadD26 NC_008769.1 3197686 3199437 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3197686..3199437 Mycobacterium bovis BCG str. Pasteur 1173P2 4699366 YP_979037.1 CDS ppsA NC_008769.1 3199434 3205064 D Differs from Rv2931 at several positions; phenolpthiocerol synthesis type-I polyketide synthase ppsA 3199434..3205064 Mycobacterium bovis BCG str. Pasteur 1173P2 4696810 YP_979038.1 CDS ppsB NC_008769.1 3205061 3209677 D Differs from Mb2957 and Rv2932 at several positions; phenolpthiocerol synthesis type-I polyketide synthase ppsB 3205061..3209677 Mycobacterium bovis BCG str. Pasteur 1173P2 4696369 YP_979039.1 CDS ppsC NC_008769.1 3209674 3216240 D phenolpthiocerol synthesis type-I polyketide synthase ppsC 3209674..3216240 Mycobacterium bovis BCG str. Pasteur 1173P2 4696370 YP_979040.1 CDS ppsD NC_008769.1 3216237 3221720 D Differs from Rv2934 at several positions; phenolpthiocerol synthesis type-I polyketide synthase ppsD 3216237..3221720 Mycobacterium bovis BCG str. Pasteur 1173P2 4696371 YP_979041.1 CDS ppsE NC_008769.1 3221726 3226192 D Differs from Rv2935 at several positions; phenolpthiocerol synthesis type-I polyketide synthase ppsE 3221726..3226192 Mycobacterium bovis BCG str. Pasteur 1173P2 4696372 YP_979042.1 CDS drrA NC_008769.1 3226203 3227198 D Differs from Rv2936 by 1aa, D309H; daunorubicin-DIM-transport ATP-binding protein ABC transporter drrA 3226203..3227198 Mycobacterium bovis BCG str. Pasteur 1173P2 4696488 YP_979043.1 CDS drrB NC_008769.1 3227195 3228064 D daunorubicin-DIM-transport integral membrane protein ABC transporter drrB 3227195..3228064 Mycobacterium bovis BCG str. Pasteur 1173P2 4697913 YP_979044.1 CDS drrC NC_008769.1 3228061 3228891 D daunorubicin-DIM-transport integral membrane protein ABC transporter drrC 3228061..3228891 Mycobacterium bovis BCG str. Pasteur 1173P2 4695804 YP_979045.1 CDS papA5 NC_008769.1 3228938 3230206 D required for PDIM synthesis; phthiocerol and phthiodiolone dimycocerosate esters are scaffolds used for virulence-enhancing lipids; proposed to catalyze diesterification of phthiocerol and phthiodolone with mycocerosate; functions in polyketide synthesis; acyltransferase 3228938..3230206 Mycobacterium bovis BCG str. Pasteur 1173P2 4698462 YP_979046.1 CDS mas NC_008769.1 3230369 3236704 R multifunctional mycocerosic acid synthase membrane-associated mas complement(3230369..3236704) Mycobacterium bovis BCG str. Pasteur 1173P2 4697547 YP_979047.1 CDS fadD28 NC_008769.1 3237324 3239066 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3237324..3239066 Mycobacterium bovis BCG str. Pasteur 1173P2 4698663 YP_979048.1 CDS mmpL7 NC_008769.1 3239059 3241821 D transmembrane transport protein mmpL7 3239059..3241821 Mycobacterium bovis BCG str. Pasteur 1173P2 4697440 YP_979049.1 CDS BCG_2965 NC_008769.1 3242453 3243694 D transposase for insertion sequence element IS1533 3242453..3243694 Mycobacterium bovis BCG str. Pasteur 1173P2 4696173 YP_979050.1 CDS BCG_2966 NC_008769.1 3243694 3244224 D transposase 3243694..3244224 Mycobacterium bovis BCG str. Pasteur 1173P2 4699139 YP_979051.1 CDS lppX NC_008769.1 3244613 3245314 R lipoprotein lppX complement(3244613..3245314) Mycobacterium bovis BCG str. Pasteur 1173P2 4698622 YP_979052.1 CDS pks1 NC_008769.1 3245663 3252001 R In Mycobacterium tuberculosis H37Rv, pks1 and pks15 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-g) results in a single product that is more similar to pks1. Differs from Rv2946c by 2aa, G1779V, V1859A, and from Rv2947c by 2aa, A333V, R374G; polyketide synthase pks1 complement(3245663..3252001) Mycobacterium bovis BCG str. Pasteur 1173P2 4698613 YP_979053.1 CDS fadD22 NC_008769.1 3251998 3254115 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(3251998..3254115) Mycobacterium bovis BCG str. Pasteur 1173P2 4696189 YP_979054.1 CDS BCG_2970c NC_008769.1 3254132 3254731 R hypothetical protein complement(3254132..3254731) Mycobacterium bovis BCG str. Pasteur 1173P2 4697263 YP_979055.1 CDS fadD29 NC_008769.1 3254757 3256616 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(3254757..3256616) Mycobacterium bovis BCG str. Pasteur 1173P2 4699144 YP_979056.1 CDS BCG_2972c NC_008769.1 3257264 3258409 R oxidoreductase complement(3257264..3258409) Mycobacterium bovis BCG str. Pasteur 1173P2 4698078 YP_979057.1 CDS BCG_2973 NC_008769.1 3258602 3259414 D methyltransferase 3258602..3259414 Mycobacterium bovis BCG str. Pasteur 1173P2 4698612 YP_979058.1 CDS BCG_2974 NC_008769.1 3259440 3260696 D hypothetical protein 3259440..3260696 Mycobacterium bovis BCG str. Pasteur 1173P2 4698602 YP_979059.1 CDS BCG_2975c NC_008769.1 3260827 3261552 R Differs from Rv2954c and Mb2978c by 1aa, Q194R; hypothetical protein complement(3260827..3261552) Mycobacterium bovis BCG str. Pasteur 1173P2 4698582 YP_979060.1 CDS BCG_2976c NC_008769.1 3261741 3262706 R Differs from Rv2955c by 1aa, H27R; hypothetical protein complement(3261741..3262706) Mycobacterium bovis BCG str. Pasteur 1173P2 4698501 YP_979061.1 CDS BCG_2977 NC_008769.1 3262829 3263560 D Differs from Rv2956 by 1aa, T237I; hypothetical protein 3262829..3263560 Mycobacterium bovis BCG str. Pasteur 1173P2 4699372 YP_979062.1 CDS BCG_2978 NC_008769.1 3263631 3264458 D glycosyl transferase family protein 3263631..3264458 Mycobacterium bovis BCG str. Pasteur 1173P2 4699132 YP_979063.1 CDS BCG_2979c NC_008769.1 3265062 3266162 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; glycosyl transferase family protein complement(3265062..3266162) Mycobacterium bovis BCG str. Pasteur 1173P2 4699360 YP_979064.1 CDS BCG_2980c NC_008769.1 3266263 3267000 R methyltransferase complement(3266263..3267000) Mycobacterium bovis BCG str. Pasteur 1173P2 4699276 YP_979065.1 CDS BCG_2981c NC_008769.1 3267115 3267363 R hypothetical protein complement(3267115..3267363) Mycobacterium bovis BCG str. Pasteur 1173P2 4698451 YP_979066.1 CDS BCG_2982 NC_008769.1 3267445 3267834 D transposase 3267445..3267834 Mycobacterium bovis BCG str. Pasteur 1173P2 4699036 YP_979067.1 CDS BCG_2983c NC_008769.1 3267935 3269284 R glycosyl transferase family protein complement(3267935..3269284) Mycobacterium bovis BCG str. Pasteur 1173P2 4698528 YP_979068.1 CDS BCG_2984 NC_008769.1 3269398 3270618 D integral membrane protein 3269398..3270618 Mycobacterium bovis BCG str. Pasteur 1173P2 4699354 YP_979069.1 CDS purU NC_008769.1 3270691 3271623 D produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 3270691..3271623 Mycobacterium bovis BCG str. Pasteur 1173P2 4697912 YP_979070.1 CDS coaD NC_008769.1 3272492 3272977 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(3272492..3272977) Mycobacterium bovis BCG str. Pasteur 1173P2 4696060 YP_979071.1 CDS BCG_2987c NC_008769.1 3273063 3273629 R methyltransferase complement(3273063..3273629) Mycobacterium bovis BCG str. Pasteur 1173P2 4696454 YP_979072.1 CDS pca NC_008769.1 3273825 3277208 R biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate; pyruvate carboxylase complement(3273825..3277208) Mycobacterium bovis BCG str. Pasteur 1173P2 4698328 YP_979073.1 CDS BCG_2989c NC_008769.1 3277233 3277865 R integral membrane protein complement(3277233..3277865) Mycobacterium bovis BCG str. Pasteur 1173P2 4698835 YP_979074.1 CDS BCG_2990c NC_008769.1 3277871 3278638 R membrane or hypothetical protein complement(3277871..3278638) Mycobacterium bovis BCG str. Pasteur 1173P2 4696395 YP_979075.1 CDS lipN NC_008769.1 3278735 3279865 R lipase/esterase lipN complement(3278735..3279865) Mycobacterium bovis BCG str. Pasteur 1173P2 4698333 YP_979076.1 CDS BCG_2992 NC_008769.1 3280096 3280266 D hypothetical protein 3280096..3280266 Mycobacterium bovis BCG str. Pasteur 1173P2 4698635 YP_979077.1 CDS BCG_2993 NC_008769.1 3280263 3281111 D Differs from Rv2971 by 1aa, H152N; oxidoreductase 3280263..3281111 Mycobacterium bovis BCG str. Pasteur 1173P2 4698228 YP_979078.1 CDS BCG_2994c NC_008769.1 3281185 3281898 R hypothetical protein complement(3281185..3281898) Mycobacterium bovis BCG str. Pasteur 1173P2 4698611 YP_979079.1 CDS recG NC_008769.1 3281895 3284108 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(3281895..3284108) Mycobacterium bovis BCG str. Pasteur 1173P2 4698230 YP_979080.1 CDS BCG_2996c NC_008769.1 3284111 3285772 R In Mycobacterium tuberculosis H37Rv, Rv2975c and Rv2974c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 2 bp deletion (cg-*) results in a single product that is more similar to Rv2974c; hypothetical protein complement(3284111..3285772) Mycobacterium bovis BCG str. Pasteur 1173P2 4695838 YP_979081.1 CDS ung NC_008769.1 3286231 3286914 R Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase complement(3286231..3286914) Mycobacterium bovis BCG str. Pasteur 1173P2 4698022 YP_979082.1 CDS thiL NC_008769.1 3286947 3287948 R catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase complement(3286947..3287948) Mycobacterium bovis BCG str. Pasteur 1173P2 4696501 YP_979083.1 CDS BCG_2999c NC_008769.1 3287945 3289324 R transposase complement(3287945..3289324) Mycobacterium bovis BCG str. Pasteur 1173P2 4695453 YP_979084.1 CDS BCG_3000c NC_008769.1 3289324 3289908 R Differs from Rv2979c by 3aa, R14P, A79T, G151D; resolvase complement(3289324..3289908) Mycobacterium bovis BCG str. Pasteur 1173P2 4699361 YP_979085.1 CDS BCG_3001 NC_008769.1 3290120 3290665 D hypothetical protein 3290120..3290665 Mycobacterium bovis BCG str. Pasteur 1173P2 4698293 YP_979086.1 CDS ddl NC_008769.1 3291310 3292431 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(3291310..3292431) Mycobacterium bovis BCG str. Pasteur 1173P2 4698165 YP_979087.1 CDS gpsA NC_008769.1 3292509 3293513 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(3292509..3293513) Mycobacterium bovis BCG str. Pasteur 1173P2 4697648 YP_979088.1 CDS BCG_3004 NC_008769.1 3293632 3294276 D hypothetical protein 3293632..3294276 Mycobacterium bovis BCG str. Pasteur 1173P2 4697625 YP_979089.1 CDS ppk NC_008769.1 3294368 3296596 D catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 3294368..3296596 Mycobacterium bovis BCG str. Pasteur 1173P2 4699068 YP_979090.1 CDS mutT1 NC_008769.1 3296679 3297632 D hydrolase mutT1 3296679..3297632 Mycobacterium bovis BCG str. Pasteur 1173P2 4698102 YP_979091.1 CDS hupB NC_008769.1 3297690 3298307 R Differs from Rv2986c and Mb3010c by 9aa deletion at position 137; DNA-binding protein HU hupB complement(3297690..3298307) Mycobacterium bovis BCG str. Pasteur 1173P2 4697973 YP_979092.1 CDS leuD NC_008769.1 3298520 3299116 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(3298520..3299116) Mycobacterium bovis BCG str. Pasteur 1173P2 4697264 YP_979093.1 CDS leuC NC_008769.1 3299141 3300562 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(3299141..3300562) Mycobacterium bovis BCG str. Pasteur 1173P2 4697484 YP_979094.1 CDS BCG_3010 NC_008769.1 3300634 3301335 D transcriptional regulatory protein 3300634..3301335 Mycobacterium bovis BCG str. Pasteur 1173P2 4697483 YP_979095.1 CDS BCG_3011c NC_008769.1 3301346 3302206 R Differs from Mb3014c by 1aa, A217E; hypothetical protein complement(3301346..3302206) Mycobacterium bovis BCG str. Pasteur 1173P2 4698651 YP_979096.1 CDS BCG_3012 NC_008769.1 3302469 3302960 D Differs from Rv2991 by 1aa, T93A; hypothetical protein 3302469..3302960 Mycobacterium bovis BCG str. Pasteur 1173P2 4698376 YP_979097.1 CDS gltX NC_008769.1 3303292 3304764 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(3303292..3304764) Mycobacterium bovis BCG str. Pasteur 1173P2 4696853 YP_979098.1 CDS BCG_3014c NC_008769.1 3304761 3305480 R 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase complement(3304761..3305480) Mycobacterium bovis BCG str. Pasteur 1173P2 4697845 YP_979099.1 CDS BCG_3015 NC_008769.1 3305756 3307093 D integral membrane protein 3305756..3307093 Mycobacterium bovis BCG str. Pasteur 1173P2 4699349 YP_979100.1 CDS leuB NC_008769.1 3306945 3307955 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(3306945..3307955) Mycobacterium bovis BCG str. Pasteur 1173P2 4698609 YP_979101.1 CDS serA1 NC_008769.1 3307970 3309556 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(3307970..3309556) Mycobacterium bovis BCG str. Pasteur 1173P2 4697482 YP_979102.1 CDS BCG_3018 NC_008769.1 3309586 3311028 D Differs from Rv2997 by 1aa S108C; alanine rich dehydrogenase 3309586..3311028 Mycobacterium bovis BCG str. Pasteur 1173P2 4697883 YP_979103.1 CDS BCG_3019 NC_008769.1 3311302 3311763 D hypothetical protein 3311302..3311763 Mycobacterium bovis BCG str. Pasteur 1173P2 4698173 YP_979104.1 CDS BCG_3020c NC_008769.1 3311712 3311915 R hypothetical protein complement(3311712..3311915) Mycobacterium bovis BCG str. Pasteur 1173P2 4699381 YP_979105.1 CDS lppY NC_008769.1 3312089 3313054 D Differs from Rv2999 by 1aa, L212M; lipoprotein lppY 3312089..3313054 Mycobacterium bovis BCG str. Pasteur 1173P2 4699367 YP_979106.1 CDS BCG_3022 NC_008769.1 3313099 3313758 D hypothetical protein 3313099..3313758 Mycobacterium bovis BCG str. Pasteur 1173P2 4698614 YP_979107.1 CDS ilvC NC_008769.1 3314072 3315073 R catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase complement(3314072..3315073) Mycobacterium bovis BCG str. Pasteur 1173P2 4698160 YP_979108.1 CDS ilvH NC_008769.1 3315111 3315617 R with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit complement(3315111..3315617) Mycobacterium bovis BCG str. Pasteur 1173P2 4699340 YP_979109.1 CDS ilvB1 NC_008769.1 3315617 3317473 R acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 1 catalytic subunit complement(3315617..3317473) Mycobacterium bovis BCG str. Pasteur 1173P2 4698974 YP_979110.1 CDS cfp6 NC_008769.1 3317835 3318173 D low molecular weight protein antigen 6 cfp6 3317835..3318173 Mycobacterium bovis BCG str. Pasteur 1173P2 4699338 YP_979111.1 CDS BCG_3027c NC_008769.1 3318180 3319019 R hypothetical protein complement(3318180..3319019) Mycobacterium bovis BCG str. Pasteur 1173P2 4697041 YP_979112.1 CDS lppZ NC_008769.1 3319196 3320317 D Differs from Rv3006 by 1aa, D219G; lipoprotein lppZ 3319196..3320317 Mycobacterium bovis BCG str. Pasteur 1173P2 4698897 YP_979113.1 CDS BCG_3029c NC_008769.1 3320323 3320937 R oxidoreductase complement(3320323..3320937) Mycobacterium bovis BCG str. Pasteur 1173P2 4698615 YP_979114.1 CDS BCG_3030 NC_008769.1 3321131 3321754 D hypothetical protein 3321131..3321754 Mycobacterium bovis BCG str. Pasteur 1173P2 4698277 YP_979115.1 CDS gatB NC_008769.1 3321751 3323280 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(3321751..3323280) Mycobacterium bovis BCG str. Pasteur 1173P2 4699219 YP_979116.1 CDS pfkA NC_008769.1 3323310 3324341 R catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase complement(3323310..3324341) Mycobacterium bovis BCG str. Pasteur 1173P2 4695748 YP_979117.1 CDS gatA NC_008769.1 3324437 3325921 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(3324437..3325921) Mycobacterium bovis BCG str. Pasteur 1173P2 4698542 YP_979118.1 CDS gatC NC_008769.1 3325918 3326217 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C complement(3325918..3326217) Mycobacterium bovis BCG str. Pasteur 1173P2 4695747 YP_979119.1 CDS BCG_3035 NC_008769.1 3326302 3326958 D hypothetical protein 3326302..3326958 Mycobacterium bovis BCG str. Pasteur 1173P2 4695749 YP_979120.1 CDS ligA NC_008769.1 3327032 3329107 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(3327032..3329107) Mycobacterium bovis BCG str. Pasteur 1173P2 4698197 YP_979121.1 CDS BCG_3037c NC_008769.1 3329138 3330151 R hypothetical protein complement(3329138..3330151) Mycobacterium bovis BCG str. Pasteur 1173P2 4697272 YP_979122.1 CDS lpqA NC_008769.1 3330245 3330874 D lipoprotein lpqA 3330245..3330874 Mycobacterium bovis BCG str. Pasteur 1173P2 4698339 YP_979123.1 CDS esxQ NC_008769.1 3330977 3331339 R ESAT-6 like protein 8 esxQ complement(3330977..3331339) Mycobacterium bovis BCG str. Pasteur 1173P2 4698616 YP_979124.1 CDS PPE46 NC_008769.1 3331426 3332739 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 56 bp deletion leads to a product slightly different at the Nh2-terminus part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (434 aa versus 437 aa). Differs from Rv3018c by 1aa, A53V, and Mb3043c by 1aa, L328V; PPE family protein complement(3331426..3332739) Mycobacterium bovis BCG str. Pasteur 1173P2 4697503 YP_979126.1 CDS esxR NC_008769.1 3333142 3333432 R ESAT-6 like protein 9 esxR complement(3333142..3333432) Mycobacterium bovis BCG str. Pasteur 1173P2 4697128 YP_979127.1 CDS esxS NC_008769.1 3333467 3333760 R PE family protein complement(3333467..3333760) Mycobacterium bovis BCG str. Pasteur 1173P2 4696143 YP_979128.1 CDS PPE47 NC_008769.1 3333807 3335114 R In Mycobacterium Mycobacterium tuberculosis H37Rv, PPE47 and PPE48 exist as 2 separate genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-g) leads to a single product; PPE family protein complement(3333807..3335114) Mycobacterium bovis BCG str. Pasteur 1173P2 4696291 YP_979129.1 CDS PE29 NC_008769.1 3335111 3335425 R PE family protein complement(3335111..3335425) Mycobacterium bovis BCG str. Pasteur 1173P2 4696407 YP_979130.1 CDS BCG_3046c NC_008769.1 3335807 3337054 R Differs from Rv3023c by 1aa T9A; transposase complement(3335807..3337054) Mycobacterium bovis BCG str. Pasteur 1173P2 4697129 YP_979131.1 CDS mnmA NC_008769.1 3337217 3338320 R catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA complement(3337217..3338320) Mycobacterium bovis BCG str. Pasteur 1173P2 4698236 YP_979132.1 CDS iscS NC_008769.1 3338317 3339498 R cysteine desulfurase iscS complement(3338317..3339498) Mycobacterium bovis BCG str. Pasteur 1173P2 4697330 YP_979133.1 CDS BCG_3049c NC_008769.1 3339595 3340509 R hypothetical protein complement(3339595..3340509) Mycobacterium bovis BCG str. Pasteur 1173P2 4697434 YP_979134.1 CDS BCG_3050c NC_008769.1 3340506 3341246 R hypothetical protein complement(3340506..3341246) Mycobacterium bovis BCG str. Pasteur 1173P2 4698512 YP_979135.1 CDS fixB NC_008769.1 3341507 3342463 R Differs from Rv3028c by 1aa, V312A; electron transfer flavoprotein (alpha-subunit) fixB complement(3341507..3342463) Mycobacterium bovis BCG str. Pasteur 1173P2 4696482 YP_979136.1 CDS fixA NC_008769.1 3342502 3343302 R electron transfer flavoprotein (beta-subunit) fixA complement(3342502..3343302) Mycobacterium bovis BCG str. Pasteur 1173P2 4695797 YP_979137.1 CDS BCG_3053 NC_008769.1 3343533 3344357 D hypothetical protein 3343533..3344357 Mycobacterium bovis BCG str. Pasteur 1173P2 4695796 YP_979138.1 CDS BCG_3054 NC_008769.1 3344354 3345934 D hypothetical protein 3344354..3345934 Mycobacterium bovis BCG str. Pasteur 1173P2 4697615 YP_979139.1 CDS BCG_3055 NC_008769.1 3345966 3347210 D Differs from Rv3032 and Mb3058 by 1aa, P380Q; transferase 3345966..3347210 Mycobacterium bovis BCG str. Pasteur 1173P2 4698985 YP_979140.1 CDS BCG_3056 NC_008769.1 3347244 3347633 D hypothetical protein 3347244..3347633 Mycobacterium bovis BCG str. Pasteur 1173P2 4696061 YP_979141.1 CDS BCG_3057 NC_008769.1 3347812 3348360 D hypothetical protein 3347812..3348360 Mycobacterium bovis BCG str. Pasteur 1173P2 4699087 YP_979142.1 CDS BCG_3058c NC_008769.1 3348451 3349353 R transferase complement(3348451..3349353) Mycobacterium bovis BCG str. Pasteur 1173P2 4698604 YP_979143.1 CDS BCG_3059 NC_008769.1 3349811 3350893 D hypothetical protein 3349811..3350893 Mycobacterium bovis BCG str. Pasteur 1173P2 4695705 YP_979144.1 CDS TB22.2 NC_008769.1 3350890 3351573 R Differs from Mb3062c by 1aa, Q63R; hypothetical protein complement(3350890..3351573) Mycobacterium bovis BCG str. Pasteur 1173P2 4698149 YP_979145.1 CDS BCG_3061c NC_008769.1 3351646 3352722 R Differs from Rv3037c by 1aa, A7D; hypothetical protein complement(3351646..3352722) Mycobacterium bovis BCG str. Pasteur 1173P2 4697563 YP_979146.1 CDS BCG_3062c NC_008769.1 3352857 3353840 R hypothetical protein complement(3352857..3353840) Mycobacterium bovis BCG str. Pasteur 1173P2 4699369 YP_979147.1 CDS echA17 NC_008769.1 3353851 3354615 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(3353851..3354615) Mycobacterium bovis BCG str. Pasteur 1173P2 4699010 YP_979148.1 CDS BCG_3064c NC_008769.1 3354624 3355490 R hypothetical protein complement(3354624..3355490) Mycobacterium bovis BCG str. Pasteur 1173P2 4695778 YP_979149.1 CDS BCG_3065c NC_008769.1 3355487 3356350 R ABC transporter ATP-binding protein complement(3355487..3356350) Mycobacterium bovis BCG str. Pasteur 1173P2 4698104 YP_979150.1 CDS serB2 NC_008769.1 3356365 3357594 R Differs from Rv3042c by 2aa, S70A, E116G; phosphoserine phosphatase serB2 complement(3356365..3357594) Mycobacterium bovis BCG str. Pasteur 1173P2 4699373 YP_979151.1 CDS ctaD NC_008769.1 3357632 3359353 R cytochrome C oxidase polypeptide I ctaD complement(3357632..3359353) Mycobacterium bovis BCG str. Pasteur 1173P2 4696250 YP_979152.1 CDS fecB NC_008769.1 3359568 3360647 D FeIII-dicitrate-binding periplasmic lipoprotein fecB 3359568..3360647 Mycobacterium bovis BCG str. Pasteur 1173P2 4698123 YP_979153.1 CDS adhC NC_008769.1 3360717 3361757 D NADP-dependent alcohol dehydrogenase adhC 3360717..3361757 Mycobacterium bovis BCG str. Pasteur 1173P2 4695363 YP_979154.1 CDS BCG_3070c NC_008769.1 3361746 3362120 R hypothetical protein complement(3361746..3362120) Mycobacterium bovis BCG str. Pasteur 1173P2 4696512 YP_979155.1 CDS BCG_3071c NC_008769.1 3362454 3362738 R hypothetical protein complement(3362454..3362738) Mycobacterium bovis BCG str. Pasteur 1173P2 4697966 YP_979156.1 CDS nrdF NC_008769.1 3362836 3363810 R B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta complement(3362836..3363810) Mycobacterium bovis BCG str. Pasteur 1173P2 4696111 YP_979157.1 CDS BCG_3073c NC_008769.1 3363941 3365515 R monooxygenase complement(3363941..3365515) Mycobacterium bovis BCG str. Pasteur 1173P2 4698715 YP_979158.1 CDS BCG_3074c NC_008769.1 3365649 3366389 R AsnC family transcriptional regulator complement(3365649..3366389) Mycobacterium bovis BCG str. Pasteur 1173P2 4698105 YP_979159.1 CDS nrdE NC_008769.1 3366517 3368598 R Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha complement(3366517..3368598) Mycobacterium bovis BCG str. Pasteur 1173P2 4697914 YP_979160.1 CDS nrdI NC_008769.1 3368664 3369116 R in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein complement(3368664..3369116) Mycobacterium bovis BCG str. Pasteur 1173P2 4698714 YP_979161.1 CDS nrdH NC_008769.1 3369151 3369390 R glutaredoxin electron transport component of nrdEF (glutaredoxin-like protein) nrdH complement(3369151..3369390) Mycobacterium bovis BCG str. Pasteur 1173P2 4698717 YP_979162.1 CDS BCG_3078c NC_008769.1 3369368 3369736 R hypothetical protein complement(3369368..3369736) Mycobacterium bovis BCG str. Pasteur 1173P2 4698716 YP_979163.1 CDS BCG_3079c NC_008769.1 3369853 3370407 R hypothetical protein complement(3369853..3370407) Mycobacterium bovis BCG str. Pasteur 1173P2 4697903 YP_979164.1 CDS BCG_3080 NC_008769.1 3370499 3371113 D TetR family transcriptional regulator 3370499..3371113 Mycobacterium bovis BCG str. Pasteur 1173P2 4697980 YP_979165.1 CDS dinP NC_008769.1 3371123 3372163 D involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 3371123..3372163 Mycobacterium bovis BCG str. Pasteur 1173P2 4697981 YP_979166.1 CDS BCG_3082c NC_008769.1 3372217 3373080 R short chain dehydrogenase complement(3372217..3373080) Mycobacterium bovis BCG str. Pasteur 1173P2 4696052 YP_979167.1 CDS BCG_3083c NC_008769.1 3373144 3373794 R TetR family transcriptional regulator complement(3373144..3373794) Mycobacterium bovis BCG str. Pasteur 1173P2 4698077 YP_979168.1 CDS cyp136 NC_008769.1 3373910 3375388 D Differs from Mb3085 by 1aa, E44K and Rv3059 by 2aa, E44K, G445D; cytochrome P450 136 cyp136 3373910..3375388 Mycobacterium bovis BCG str. Pasteur 1173P2 4697976 YP_979169.1 CDS BCG_3085c NC_008769.1 3376159 3377631 R GntR family transcriptional regulator complement(3376159..3377631) Mycobacterium bovis BCG str. Pasteur 1173P2 4698529 YP_979170.1 CDS fadE22 NC_008769.1 3377748 3379913 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium tuberculosis strain H37Rv, fadE22 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-c) splits fadE22 into 2 parts, fadE22a and fadE22b. Differs from Mb3087c and from Rv3061c by 2aa, E488K, C497S; acyl-CoA dehydrogenase fadE22 complement(3377748..3379913) Mycobacterium bovis BCG str. Pasteur 1173P2 4697991 YP_979171.1 CDS ligB NC_008769.1 3380070 3381593 D catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; ATP-dependent DNA ligase 3380070..3381593 Mycobacterium bovis BCG str. Pasteur 1173P2 4699121 YP_979172.1 CDS cstA NC_008769.1 3381729 3384005 D Differs from Rv3063 by 3aa, C402G, S559R, P600L; carbon starvation protein A cstA 3381729..3384005 Mycobacterium bovis BCG str. Pasteur 1173P2 4697273 YP_979173.1 CDS BCG_3089c NC_008769.1 3384311 3384736 R integral membrane protein complement(3384311..3384736) Mycobacterium bovis BCG str. Pasteur 1173P2 4697932 YP_979174.1 CDS mmr NC_008769.1 3384873 3385196 D multidrugs-transport integral membrane protein mmr 3384873..3385196 Mycobacterium bovis BCG str. Pasteur 1173P2 4697994 YP_979175.1 CDS BCG_3091 NC_008769.1 3385193 3385801 D DeoR family transcriptional regulator 3385193..3385801 Mycobacterium bovis BCG str. Pasteur 1173P2 4697599 YP_979176.1 CDS BCG_3092 NC_008769.1 3385914 3386324 D Differs from Rv3067 and Mb3094 by 1aa A3T; hypothetical protein 3385914..3386324 Mycobacterium bovis BCG str. Pasteur 1173P2 4697982 YP_979177.1 CDS pgmA NC_008769.1 3386465 3388108 R catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase complement(3386465..3388108) Mycobacterium bovis BCG str. Pasteur 1173P2 4697080 YP_979178.1 CDS BCG_3094 NC_008769.1 3388178 3388576 D may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 3388178..3388576 Mycobacterium bovis BCG str. Pasteur 1173P2 4698855 YP_979179.1 CDS BCG_3095 NC_008769.1 3388573 3388953 D may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 3388573..3388953 Mycobacterium bovis BCG str. Pasteur 1173P2 4697995 YP_979180.1 CDS BCG_3096 NC_008769.1 3388950 3390059 D hypothetical protein 3388950..3390059 Mycobacterium bovis BCG str. Pasteur 1173P2 4696534 YP_979181.1 CDS BCG_3097c NC_008769.1 3390284 3390808 R hypothetical protein complement(3390284..3390808) Mycobacterium bovis BCG str. Pasteur 1173P2 4698777 YP_979182.1 CDS BCG_3098c NC_008769.1 3390815 3391171 R hypothetical protein complement(3390815..3391171) Mycobacterium bovis BCG str. Pasteur 1173P2 4696731 YP_979183.1 CDS BCG_3099 NC_008769.1 3391265 3392539 D hypothetical protein 3391265..3392539 Mycobacterium bovis BCG str. Pasteur 1173P2 4698058 YP_979184.1 CDS BCG_3100c NC_008769.1 3392536 3393459 R hypothetical protein complement(3392536..3393459) Mycobacterium bovis BCG str. Pasteur 1173P2 4698912 YP_979185.1 CDS BCG_3101 NC_008769.1 3393558 3394034 D hypothetical protein 3393558..3394034 Mycobacterium bovis BCG str. Pasteur 1173P2 4698732 YP_979186.1 CDS BCG_3102 NC_008769.1 3394027 3395838 D Differs from Rv3077 by 1aa R311G; hydrolase 3394027..3395838 Mycobacterium bovis BCG str. Pasteur 1173P2 4698690 YP_979187.1 CDS hab NC_008769.1 3395839 3396240 D hydroxylaminobenzene mutase hab 3395839..3396240 Mycobacterium bovis BCG str. Pasteur 1173P2 4698718 YP_979188.1 CDS BCG_3104c NC_008769.1 3396256 3397083 R hypothetical protein complement(3396256..3397083) Mycobacterium bovis BCG str. Pasteur 1173P2 4695479 YP_979189.1 CDS pknK NC_008769.1 3397142 3400474 R Differs from Rv3080c by 1aa, V217A; serine/threonine-protein kinase transcriptional regulatory protein pknK complement(3397142..3400474) Mycobacterium bovis BCG str. Pasteur 1173P2 4698735 YP_979190.1 CDS BCG_3106 NC_008769.1 3400526 3401764 D Differs from Rv3081 and Mb3108 by 1aa, A108V; hypothetical protein 3400526..3401764 Mycobacterium bovis BCG str. Pasteur 1173P2 4697526 YP_979191.1 CDS virS NC_008769.1 3401890 3402912 R Differs from Rv3082c by 1aa, C322R; virulence-regulating transcriptional regulator VirS complement(3401890..3402912) Mycobacterium bovis BCG str. Pasteur 1173P2 4698733 YP_979192.1 CDS BCG_3108 NC_008769.1 3402990 3404477 D Differs from Mb3110 by 1aa, S81I and from Rv3083 by 2aa, S81I, I94V; monooxygenase 3402990..3404477 Mycobacterium bovis BCG str. Pasteur 1173P2 4697232 YP_979193.1 CDS lipR NC_008769.1 3404483 3405409 D Differs from Rv3084 and Mb3111 by 1aa, G276S; acetyl-hydrolase/esterase lipR 3404483..3405409 Mycobacterium bovis BCG str. Pasteur 1173P2 4698744 YP_979194.1 CDS BCG_3110 NC_008769.1 3405406 3406236 D short-chain type dehydrogenase/reductase 3405406..3406236 Mycobacterium bovis BCG str. Pasteur 1173P2 4696904 YP_979195.1 CDS adhD NC_008769.1 3406267 3407373 D zinc-type alcohol dehydrogenase adhD 3406267..3407373 Mycobacterium bovis BCG str. Pasteur 1173P2 4698740 YP_979196.1 CDS BCG_3112 NC_008769.1 3407411 3408829 D Differs from Rv3087 by 1aa, V447L, and from Mb3114 by 1aa, T158A; hypothetical protein 3407411..3408829 Mycobacterium bovis BCG str. Pasteur 1173P2 4695601 YP_979197.1 CDS BCG_3113 NC_008769.1 3408826 3410250 D hypothetical protein 3408826..3410250 Mycobacterium bovis BCG str. Pasteur 1173P2 4698742 YP_979198.1 CDS fadD13 NC_008769.1 3410247 3411758 D chain-fatty-acid-CoA ligase fadD13 3410247..3411758 Mycobacterium bovis BCG str. Pasteur 1173P2 4698712 YP_979199.1 CDS BCG_3115 NC_008769.1 3412697 3413584 D hypothetical protein 3412697..3413584 Mycobacterium bovis BCG str. Pasteur 1173P2 4695381 YP_979200.1 CDS BCG_3116 NC_008769.1 3413602 3415293 D hypothetical protein 3413602..3415293 Mycobacterium bovis BCG str. Pasteur 1173P2 4698728 YP_979201.1 CDS BCG_3117c NC_008769.1 3415300 3416220 R Differs from Mb3119c by 1 aa, I237M; integral membrane protein complement(3415300..3416220) Mycobacterium bovis BCG str. Pasteur 1173P2 4698739 YP_979202.1 CDS BCG_3118c NC_008769.1 3416246 3417250 R Differs from Rv3093c by 1aa W210C; oxidoreductase complement(3416246..3417250) Mycobacterium bovis BCG str. Pasteur 1173P2 4698734 YP_979203.1 CDS BCG_3119c NC_008769.1 3417247 3418377 R hypothetical protein complement(3417247..3418377) Mycobacterium bovis BCG str. Pasteur 1173P2 4698731 YP_979204.1 CDS BCG_3120 NC_008769.1 3418459 3418935 D transcriptional regulator 3418459..3418935 Mycobacterium bovis BCG str. Pasteur 1173P2 4698753 YP_979205.1 CDS BCG_3121 NC_008769.1 3419033 3420172 D Differs from Rv3097 by 1aa G28E; hypothetical protein 3419033..3420172 Mycobacterium bovis BCG str. Pasteur 1173P2 4698736 YP_979206.1 CDS PE_PGRS63 NC_008769.1 3420264 3421577 R Differs from Rv3097c by 1aa A58G; hypothetical protein complement(3420264..3421577) Mycobacterium bovis BCG str. Pasteur 1173P2 4698748 YP_979207.1 CDS BCG_3123c NC_008769.1 3421696 3422148 R Differs from Rv3098c by 1aa E117D; hypothetical protein complement(3421696..3422148) Mycobacterium bovis BCG str. Pasteur 1173P2 4699255 YP_979208.1 CDS BCG_3124c NC_008769.1 3422899 3423750 R hypothetical protein complement(3422899..3423750) Mycobacterium bovis BCG str. Pasteur 1173P2 4698655 YP_979209.1 CDS smpB NC_008769.1 3423787 3424269 R binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein complement(3423787..3424269) Mycobacterium bovis BCG str. Pasteur 1173P2 4698752 YP_979210.1 CDS ftsX NC_008769.1 3424272 3425165 R Differs from Rv3101c by 1aa, S171N; cell division protein ftsX complement(3424272..3425165) Mycobacterium bovis BCG str. Pasteur 1173P2 4697292 YP_979211.1 CDS ftsE NC_008769.1 3425166 3425855 R cell division ATP-binding protein ftsE complement(3425166..3425855) Mycobacterium bovis BCG str. Pasteur 1173P2 4698533 YP_979212.1 CDS BCG_3128c NC_008769.1 3425899 3426336 R hypothetical protein complement(3425899..3426336) Mycobacterium bovis BCG str. Pasteur 1173P2 4695821 YP_979213.1 CDS BCG_3129c NC_008769.1 3426338 3427264 R hypothetical protein complement(3426338..3427264) Mycobacterium bovis BCG str. Pasteur 1173P2 4698108 YP_979214.1 CDS prfB NC_008769.1 3427254 3428390 R recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 complement(3427254..3428390) Mycobacterium bovis BCG str. Pasteur 1173P2 4698722 YP_979215.1 CDS fprA NC_008769.1 3428494 3429864 D Differs from Rv3106 by 2aa, I141V, D385N; NADPH:adrenodoxin oxidoreductase fprA 3428494..3429864 Mycobacterium bovis BCG str. Pasteur 1173P2 4697853 YP_979216.1 CDS agpS NC_008769.1 3429865 3431448 R alkyldihydroxyacetonephosphate synthase agpS complement(3429865..3431448) Mycobacterium bovis BCG str. Pasteur 1173P2 4697655 YP_979217.1 CDS BCG_3133 NC_008769.1 3431547 3431987 D Differs from Mb3135 by 1aa I145V; hypothetical protein 3431547..3431987 Mycobacterium bovis BCG str. Pasteur 1173P2 4695494 YP_979218.1 CDS moaA1 NC_008769.1 3432136 3433215 D Differs from Mb3136 by 1aa, T324A; molybdenum cofactor biosynthesis protein A moaA1 3432136..3433215 Mycobacterium bovis BCG str. Pasteur 1173P2 4698745 YP_979219.1 CDS moaB1 NC_008769.1 3433266 3433661 D pterin-4-alpha-carbinolamine dehydratase moaB1 3433266..3433661 Mycobacterium bovis BCG str. Pasteur 1173P2 4698506 YP_979220.1 CDS moaC NC_008769.1 3433658 3434170 D MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 3433658..3434170 Mycobacterium bovis BCG str. Pasteur 1173P2 4695602 YP_979221.1 CDS moaD1 NC_008769.1 3434187 3434438 D molybdenum cofactor biosynthesis protein MoaD 3434187..3434438 Mycobacterium bovis BCG str. Pasteur 1173P2 4695605 YP_979222.1 CDS BCG_3138 NC_008769.1 3434560 3435228 D Differs from Rv3113 by 3aa, C11W, E134G, R191L; phosphatase 3434560..3435228 Mycobacterium bovis BCG str. Pasteur 1173P2 4698494 YP_979223.1 CDS BCG_3139 NC_008769.1 3435245 3435775 D Differs from Rv3114 by 1aa, P11S; hypothetical protein 3435245..3435775 Mycobacterium bovis BCG str. Pasteur 1173P2 4698759 YP_979224.1 CDS BCG_3140 NC_008769.1 3435937 3437184 D transposase 3435937..3437184 Mycobacterium bovis BCG str. Pasteur 1173P2 4698761 YP_979225.1 CDS moeB2 NC_008769.1 3437262 3438431 D molybdenum cofactor biosynthesis protein moeB2 3437262..3438431 Mycobacterium bovis BCG str. Pasteur 1173P2 4698766 YP_979226.1 CDS cysA3 NC_008769.1 3438460 3439422 D In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a large deletion of 2775 bp (RD12) leads to the loss of the COOH part of cysA3, the following CDSs, sseC1, moaE1, Rv3120 and a large part of cyp141 except the COOH end, compared to the homolog in Mycobacterium tuberculosis strain H37Rv; thiosulfate sulfurtransferase cysA3 3438460..3439422 Mycobacterium bovis BCG str. Pasteur 1173P2 4697173 YP_979227.1 CDS BCG_3143 NC_008769.1 3439800 3440270 D Differs from Rv3122 by 1aa, S156R; hypothetical protein 3439800..3440270 Mycobacterium bovis BCG str. Pasteur 1173P2 4696712 YP_979228.1 CDS BCG_3144 NC_008769.1 3440280 3440774 D Differs from Rv3123 by 1aa, Q40R; hypothetical protein 3440280..3440774 Mycobacterium bovis BCG str. Pasteur 1173P2 4698750 YP_979229.1 CDS BCG_3145 NC_008769.1 3441217 3442086 D Differs from Rv3124 and Mb3147 by 1aa, G159E; transcriptional regulatory protein 3441217..3442086 Mycobacterium bovis BCG str. Pasteur 1173P2 4698767 YP_979230.1 CDS PPE49b NC_008769.1 3442187 3442501 R In Mycobacterium bovis BCG Pasteur, PPE49 has incurred a single base deletion in codon 272 compared to Rv3125c and Mb3148c leading to frameshift, and two products of 282 and 104 aa, compared to 391 in others; PPE family protein complement(3442187..3442501) Mycobacterium bovis BCG str. Pasteur 1173P2 4698773 YP_979231.1 CDS PPE49a NC_008769.1 3442513 3443361 R In Mycobacterium bovis BCG Pasteur, PPE49 has incurred a single base deletion in codon 272 compared to Rv3125c and Mb3148c leading to frameshift, and two products of 282 and 104 aa, compared to 391 in others. Differs from Rv3125c by 1aa, V38A; PPE family protein complement(3442513..3443361) Mycobacterium bovis BCG str. Pasteur 1173P2 4696409 YP_979232.1 CDS BCG_3148c NC_008769.1 3443518 3443832 R hypothetical protein complement(3443518..3443832) Mycobacterium bovis BCG str. Pasteur 1173P2 4696408 YP_979233.1 CDS BCG_3149 NC_008769.1 3443857 3444891 D Differs from Rv3127 by 1aa, C95F; hypothetical protein 3443857..3444891 Mycobacterium bovis BCG str. Pasteur 1173P2 4698751 YP_979234.1 CDS BCG_3150c NC_008769.1 3444878 3445228 R In Mycobacterium tuberculosis strain H37Rv, Rv3128c exists as a single gene with an in-frame amber stop codon. In Mycobacterium bovis, Rv3128c is split into 2, Mb3151c and Mb3152c; hypothetical protein complement(3444878..3445228) Mycobacterium bovis BCG str. Pasteur 1173P2 4698772 YP_979235.1 CDS BCG_3151c NC_008769.1 3445310 3445891 R In Mycobacterium tuberculosis strain H37Rv, Rv3128c exists as a single gene with an in-frame amber stop codon. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, Rv3128c is split into 2 genes; Differs from Mb3152c by 1aa, V166G; hypothetical protein complement(3445310..3445891) Mycobacterium bovis BCG str. Pasteur 1173P2 4698770 YP_979236.1 CDS BCG_3152 NC_008769.1 3446370 3446702 D hypothetical protein 3446370..3446702 Mycobacterium bovis BCG str. Pasteur 1173P2 4698783 YP_979237.1 CDS BCG_3153c NC_008769.1 3446685 3448076 R hypothetical protein complement(3446685..3448076) Mycobacterium bovis BCG str. Pasteur 1173P2 4698774 YP_979238.1 CDS BCG_3154 NC_008769.1 3448261 3449259 D hypothetical protein 3448261..3449259 Mycobacterium bovis BCG str. Pasteur 1173P2 4698776 YP_979239.1 CDS devS NC_008769.1 3449239 3450975 R Differs from Rv3132c by 1aa, T283I; two component sensor histidine kinase devS complement(3449239..3450975) Mycobacterium bovis BCG str. Pasteur 1173P2 4698764 YP_979240.1 CDS devR NC_008769.1 3450972 3451625 R two component transcriptional regulatory protein DevR complement(3450972..3451625) Mycobacterium bovis BCG str. Pasteur 1173P2 4696781 YP_979241.1 CDS BCG_3157c NC_008769.1 3451653 3452459 R hypothetical protein complement(3451653..3452459) Mycobacterium bovis BCG str. Pasteur 1173P2 4698170 YP_979242.1 CDS PPE50 NC_008769.1 3453044 3454189 D In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a large 1337 bp insertion (I-RD08) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (381 aa versus 132 aa). Differs from Mb3159 by 1aa, K213E; PPE family protein 3453044..3454189 Mycobacterium bovis BCG str. Pasteur 1173P2 4698789 YP_979243.1 CDS PPE51 NC_008769.1 3454841 3455983 D PPE family protein 3454841..3455983 Mycobacterium bovis BCG str. Pasteur 1173P2 4696877 YP_979244.1 CDS BCG_3160 NC_008769.1 3456440 3457222 D Differs from Rv3137 by 1aa, L168P; monophosphatase 3456440..3457222 Mycobacterium bovis BCG str. Pasteur 1173P2 4696878 YP_979245.1 CDS pflA NC_008769.1 3457242 3458330 D Differs from Rv3138 by 2aa, N110S, P271T, and from Mb3162 by 2aa, F257S, P270L; pyruvate formate lyase activating protein pflA 3457242..3458330 Mycobacterium bovis BCG str. Pasteur 1173P2 4698804 YP_979246.1 CDS fadE24 NC_008769.1 3458410 3459816 D acyl-CoA dehydrogenase fadE24 3458410..3459816 Mycobacterium bovis BCG str. Pasteur 1173P2 4698544 YP_979247.1 CDS fadE23 NC_008769.1 3459837 3461042 D acyl-CoA dehydrogenase fadE23 3459837..3461042 Mycobacterium bovis BCG str. Pasteur 1173P2 4697412 YP_979248.1 CDS fadB4 NC_008769.1 3461142 3462113 D NADPH quinone oxidoreductase fadB4 3461142..3462113 Mycobacterium bovis BCG str. Pasteur 1173P2 4697411 YP_979249.1 CDS BCG_3165c NC_008769.1 3462165 3462593 R Differs from Mb3166c by 1aa, H133Q; hypothetical protein complement(3462165..3462593) Mycobacterium bovis BCG str. Pasteur 1173P2 4697223 YP_979250.1 CDS BCG_3166 NC_008769.1 3462701 3463102 D response regulator 3462701..3463102 Mycobacterium bovis BCG str. Pasteur 1173P2 4698640 YP_979251.1 CDS PPE52 NC_008769.1 3463135 3464364 R Differs from Rv3144c by 1aa, G226S; PPE family protein complement(3463135..3464364) Mycobacterium bovis BCG str. Pasteur 1173P2 4697904 YP_979252.1 CDS nuoA NC_008769.1 3464729 3465115 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 3464729..3465115 Mycobacterium bovis BCG str. Pasteur 1173P2 4696879 YP_979253.1 CDS nuoB NC_008769.1 3465124 3465678 D The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 3465124..3465678 Mycobacterium bovis BCG str. Pasteur 1173P2 4699186 YP_979254.1 CDS nuoC NC_008769.1 3465675 3466385 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit C 3465675..3466385 Mycobacterium bovis BCG str. Pasteur 1173P2 4696399 YP_979255.1 CDS nuoD NC_008769.1 3466385 3467707 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 3466385..3467707 Mycobacterium bovis BCG str. Pasteur 1173P2 4696400 YP_979256.1 CDS nuoE NC_008769.1 3467704 3468462 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 3467704..3468462 Mycobacterium bovis BCG str. Pasteur 1173P2 4696401 YP_979257.1 CDS nuoF NC_008769.1 3468459 3469796 D NADH dehydrogenase I subunit F 3468459..3469796 Mycobacterium bovis BCG str. Pasteur 1173P2 4696402 YP_979258.1 CDS nuoG NC_008769.1 3469793 3472213 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 3469793..3472213 Mycobacterium bovis BCG str. Pasteur 1173P2 4696403 YP_979259.1 CDS nuoH NC_008769.1 3472329 3473561 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 3472329..3473561 Mycobacterium bovis BCG str. Pasteur 1173P2 4696594 YP_979260.1 CDS nuoI NC_008769.1 3473554 3474189 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 3473554..3474189 Mycobacterium bovis BCG str. Pasteur 1173P2 4696595 YP_979261.1 CDS nuoJ NC_008769.1 3474186 3474974 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 3474186..3474974 Mycobacterium bovis BCG str. Pasteur 1173P2 4696596 YP_979262.1 CDS nuoK NC_008769.1 3474971 3475270 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 3474971..3475270 Mycobacterium bovis BCG str. Pasteur 1173P2 4696597 YP_979263.1 CDS nuoL NC_008769.1 3475281 3477182 D Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 3475281..3477182 Mycobacterium bovis BCG str. Pasteur 1173P2 4696598 YP_979264.1 CDS nuoM NC_008769.1 3477179 3478840 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 3477179..3478840 Mycobacterium bovis BCG str. Pasteur 1173P2 4697202 YP_979265.1 CDS nuoN NC_008769.1 3478837 3480432 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 3478837..3480432 Mycobacterium bovis BCG str. Pasteur 1173P2 4697203 YP_979266.1 CDS PPE53 NC_008769.1 3480438 3482207 R In Mycobacterium bovis BCG pasteur and Mycobacterium bovis, albeit a 2146 bp insertion occurs overlapping the NH2-terminal part, this leads to an equivalent product, compared to its homolog in Mycobacterium tuberculosis strain H37Rv; Differs from Rv3159c by 2aa, deletion of A64, V87A, and from Mb3183c by 1aa, V87A; PPE family protein complement(3480438..3482207) Mycobacterium bovis BCG str. Pasteur 1173P2 4697204 YP_979267.1 CDS PPE70 NC_008769.1 3482455 3484356 R In Mycobacterium bovis BCG pasteur and Mycobacterium bovis, an insertion of 2146 bp exists between PPE53 and Rv3160c compared to Mycobacterium tuberculosis strain H37Rv. This leads to an additional gene, PPE70 equivalent to MT3248 from Mycobacterium tuberculosis strain CDC1551. Differs from Mb3184c by 1aa, deletion of A64; PPE family protein complement(3482455..3484356) Mycobacterium bovis BCG str. Pasteur 1173P2 4696880 YP_979268.1 CDS BCG_3184c NC_008769.1 3484531 3485172 R TetR family transcriptional regulator complement(3484531..3485172) Mycobacterium bovis BCG str. Pasteur 1173P2 4696415 YP_979269.1 CDS BCG_3185c NC_008769.1 3485183 3486331 R Differs from Rv3161c by 1aa, L62V; dioxygenase complement(3485183..3486331) Mycobacterium bovis BCG str. Pasteur 1173P2 4698756 YP_979270.1 CDS BCG_3186c NC_008769.1 3486247 3486837 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (t-*), leads to a longer product with different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; integral membrane protein complement(3486247..3486837) Mycobacterium bovis BCG str. Pasteur 1173P2 4698799 YP_979271.1 CDS BCG_3187c NC_008769.1 3486834 3488105 R Differs from Mb3188c by 1aa, D341E; hypothetical protein complement(3486834..3488105) Mycobacterium bovis BCG str. Pasteur 1173P2 4698801 YP_979272.1 CDS moxR3 NC_008769.1 3488135 3489097 R Differs from Mb3189c by 1aa, E20G; methanol dehydrogenase transcriptional regulatory protein moxR3 complement(3488135..3489097) Mycobacterium bovis BCG str. Pasteur 1173P2 4698795 YP_979273.1 CDS BCG_3189c NC_008769.1 3489105 3489587 R hypothetical protein complement(3489105..3489587) Mycobacterium bovis BCG str. Pasteur 1173P2 4698910 YP_979274.1 CDS BCG_3190c NC_008769.1 3489584 3490543 R Differs from Rv3166c and Mb3191c by 1aa, A202S; hypothetical protein complement(3489584..3490543) Mycobacterium bovis BCG str. Pasteur 1173P2 4698787 YP_979275.1 CDS BCG_3191c NC_008769.1 3490623 3491249 R TetR family transcriptional regulator complement(3490623..3491249) Mycobacterium bovis BCG str. Pasteur 1173P2 4698797 YP_979276.1 CDS BCG_3192 NC_008769.1 3491294 3492430 D Differs from Mb3193 by 1aa, W65R; hypothetical protein 3491294..3492430 Mycobacterium bovis BCG str. Pasteur 1173P2 4698813 YP_979277.1 CDS BCG_3193 NC_008769.1 3492430 3493554 D hypothetical protein 3492430..3493554 Mycobacterium bovis BCG str. Pasteur 1173P2 4698150 YP_979278.1 CDS aofH NC_008769.1 3493697 3495043 D flavin-containing monoamine oxidase AofH 3493697..3495043 Mycobacterium bovis BCG str. Pasteur 1173P2 4698807 YP_979279.1 CDS hpx NC_008769.1 3495038 3495937 R Differs from Rv3171c by 1aa, M201T; non-heme haloperoxidase hpx complement(3495038..3495937) Mycobacterium bovis BCG str. Pasteur 1173P2 4696663 YP_979280.1 CDS BCG_3196c NC_008769.1 3496074 3496556 R hypothetical protein complement(3496074..3496556) Mycobacterium bovis BCG str. Pasteur 1173P2 4696103 YP_979281.1 CDS BCG_3197c NC_008769.1 3496635 3497237 R TetR family transcriptional regulator complement(3496635..3497237) Mycobacterium bovis BCG str. Pasteur 1173P2 4698828 YP_979282.1 CDS BCG_3198 NC_008769.1 3497330 3498037 D Differs from Rv3174 by 1aa, A9V; short chain dehydrogenase 3497330..3498037 Mycobacterium bovis BCG str. Pasteur 1173P2 4698821 YP_979283.1 CDS BCG_3199 NC_008769.1 3498052 3499539 D catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 3498052..3499539 Mycobacterium bovis BCG str. Pasteur 1173P2 4698822 YP_979284.1 CDS mesTb NC_008769.1 3499536 3499853 R In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mesT into 2 parts, mesTa and mesTb; epoxide hydrolase mesTb complement(3499536..3499853) Mycobacterium bovis BCG str. Pasteur 1173P2 4697905 YP_979285.1 CDS mesTa NC_008769.1 3499865 3500491 R In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) splits mesT into 2 parts, mesTa and mesTb; epoxide hydrolase mesTa complement(3499865..3500491) Mycobacterium bovis BCG str. Pasteur 1173P2 4698207 YP_979286.1 CDS BCG_3202 NC_008769.1 3500638 3501498 D peroxidase 3500638..3501498 Mycobacterium bovis BCG str. Pasteur 1173P2 4696116 YP_979287.1 CDS BCG_3203 NC_008769.1 3501629 3501988 D hypothetical protein 3501629..3501988 Mycobacterium bovis BCG str. Pasteur 1173P2 4698826 YP_979288.1 CDS BCG_3204 NC_008769.1 3502228 3502521 D hypothetical protein 3502228..3502521 Mycobacterium bovis BCG str. Pasteur 1173P2 4698816 YP_979289.1 CDS BCG_3205 NC_008769.1 3502809 3504098 D hypothetical protein 3502809..3504098 Mycobacterium bovis BCG str. Pasteur 1173P2 4698824 YP_979290.1 CDS BCG_3206c NC_008769.1 3504445 3504879 R hypothetical protein complement(3504445..3504879) Mycobacterium bovis BCG str. Pasteur 1173P2 4698845 YP_979291.1 CDS BCG_3207c NC_008769.1 3504882 3505334 R hypothetical protein complement(3504882..3505334) Mycobacterium bovis BCG str. Pasteur 1173P2 4698866 YP_979292.1 CDS BCG_3208 NC_008769.1 3505565 3505909 D hypothetical protein 3505565..3505909 Mycobacterium bovis BCG str. Pasteur 1173P2 4698838 YP_979293.1 CDS BCG_3209 NC_008769.1 3505906 3506235 D transcriptional regulatory protein 3505906..3506235 Mycobacterium bovis BCG str. Pasteur 1173P2 4698868 YP_979294.1 CDS BCG_3210 NC_008769.1 3506773 3507120 D hypothetical protein 3506773..3507120 Mycobacterium bovis BCG str. Pasteur 1173P2 4698113 YP_979295.1 CDS BCG_3211 NC_008769.1 3507117 3507737 D hypothetical protein 3507117..3507737 Mycobacterium bovis BCG str. Pasteur 1173P2 4698872 YP_979296.1 CDS BCG_3212c NC_008769.1 3507897 3509162 R Differs from Rv3190c by 2aa, P138L, A330V; hypothetical protein complement(3507897..3509162) Mycobacterium bovis BCG str. Pasteur 1173P2 4698832 YP_979297.1 CDS BCG_3213c NC_008769.1 3509786 3510820 R transposase complement(3509786..3510820) Mycobacterium bovis BCG str. Pasteur 1173P2 4698886 YP_979298.1 CDS BCG_3214 NC_008769.1 3512035 3512496 D hypothetical protein 3512035..3512496 Mycobacterium bovis BCG str. Pasteur 1173P2 4697285 YP_979299.1 CDS BCG_3215c NC_008769.1 3512666 3515644 R Differs from Rv3193c by 2aa, E356Q, Q843R, and from Mb3215c by 1aa, E356Q; hypothetical protein complement(3512666..3515644) Mycobacterium bovis BCG str. Pasteur 1173P2 4698885 YP_979300.1 CDS BCG_3216c NC_008769.1 3515736 3516758 R hypothetical protein complement(3515736..3516758) Mycobacterium bovis BCG str. Pasteur 1173P2 4698877 YP_979301.1 CDS BCG_3217 NC_008769.1 3516836 3518254 D hypothetical protein 3516836..3518254 Mycobacterium bovis BCG str. Pasteur 1173P2 4698913 YP_979302.1 CDS BCG_3218 NC_008769.1 3518260 3519159 D hypothetical protein 3518260..3519159 Mycobacterium bovis BCG str. Pasteur 1173P2 4698914 YP_979303.1 CDS BCG_3219c NC_008769.1 3519168 3519368 R hypothetical protein complement(3519168..3519368) Mycobacterium bovis BCG str. Pasteur 1173P2 4698880 YP_979304.1 CDS BCG_3220 NC_008769.1 3519506 3520849 D ABC transporter ATP-binding protein 3519506..3520849 Mycobacterium bovis BCG str. Pasteur 1173P2 4698780 YP_979305.1 CDS whiB7 NC_008769.1 3520883 3521161 R transcriptional regulatory protein whiB-like whiB7 complement(3520883..3521161) Mycobacterium bovis BCG str. Pasteur 1173P2 4699274 YP_979306.1 CDS UvrD2 NC_008769.1 3521591 3523693 R DNA helicase II complement(3521591..3523693) Mycobacterium bovis BCG str. Pasteur 1173P2 4697346 YP_979307.1 CDS BCG_3223 NC_008769.1 3523817 3524071 D glutaredoxin protein 3523817..3524071 Mycobacterium bovis BCG str. Pasteur 1173P2 4697230 YP_979308.1 CDS nudC NC_008769.1 3524084 3525025 R can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase complement(3524084..3525025) Mycobacterium bovis BCG str. Pasteur 1173P2 4698241 YP_979309.1 CDS BCG_3225c NC_008769.1 3525084 3526151 R Differs from Rv3200c by 1aa, D12N; transmembrane cation transporter complement(3525084..3526151) Mycobacterium bovis BCG str. Pasteur 1173P2 4699185 YP_979310.1 CDS BCG_3226c NC_008769.1 3526213 3529518 R ATP-dependent DNA helicase complement(3526213..3529518) Mycobacterium bovis BCG str. Pasteur 1173P2 4698860 YP_979311.1 CDS BCG_3227c NC_008769.1 3529515 3532682 R Differs from Rv3202c by 1aa, A748V; ATP-dependent DNA helicase complement(3529515..3532682) Mycobacterium bovis BCG str. Pasteur 1173P2 4698870 YP_979312.1 CDS BCG_3228 NC_008769.1 3532759 3532977 D hypothetical protein 3532759..3532977 Mycobacterium bovis BCG str. Pasteur 1173P2 4698831 YP_979313.1 CDS lipV NC_008769.1 3533119 3533793 D lipase lipV 3533119..3533793 Mycobacterium bovis BCG str. Pasteur 1173P2 4699043 YP_979314.1 CDS BCG_3230 NC_008769.1 3533796 3534101 D Differs from Rv3204 by 1aa, A34T; DNA-methyltransferase 3533796..3534101 Mycobacterium bovis BCG str. Pasteur 1173P2 4695783 YP_979315.1 CDS BCG_3231c NC_008769.1 3534108 3534986 R hypothetical protein complement(3534108..3534986) Mycobacterium bovis BCG str. Pasteur 1173P2 4699356 YP_979316.1 CDS moeB1 NC_008769.1 3535013 3536191 R The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; molybdopterin biosynthesis-like protein MoeZ complement(3535013..3536191) Mycobacterium bovis BCG str. Pasteur 1173P2 4699322 YP_979317.1 CDS BCG_3233c NC_008769.1 3536282 3537139 R Differs from Rv3207c by 1aa, N157D; hypothetical protein complement(3536282..3537139) Mycobacterium bovis BCG str. Pasteur 1173P2 4697172 YP_979318.1 CDS BCG_3234 NC_008769.1 3537485 3538171 D TetR family transcriptional regulator 3537485..3538171 Mycobacterium bovis BCG str. Pasteur 1173P2 4698942 YP_979319.1 CDS TB9.4 NC_008769.1 3538158 3538430 R hypothetical protein complement(3538158..3538430) Mycobacterium bovis BCG str. Pasteur 1173P2 4699128 YP_979320.1 CDS BCG_3236 NC_008769.1 3538755 3539315 D hypothetical protein 3538755..3539315 Mycobacterium bovis BCG str. Pasteur 1173P2 4696847 YP_979321.1 CDS BCG_3237c NC_008769.1 3539325 3540020 R hypothetical protein complement(3539325..3540020) Mycobacterium bovis BCG str. Pasteur 1173P2 4699020 YP_979322.1 CDS rhlE NC_008769.1 3540279 3541862 D Differs from Mb3237 by 1aa, V17A; ATP-dependent RNA helicase rhlE 3540279..3541862 Mycobacterium bovis BCG str. Pasteur 1173P2 4698996 YP_979323.1 CDS BCG_3239 NC_008769.1 3541875 3543098 D Differs from Mb3238 by 1aa, G225D, and from Rv3212 by 2aa, G225D, A250V; hypothetical protein 3541875..3543098 Mycobacterium bovis BCG str. Pasteur 1173P2 4696799 YP_979324.1 CDS BCG_3240c NC_008769.1 3543174 3543974 R Differs from Rv3213c by 1aa, E144K; soj/parA-related protein complement(3543174..3543974) Mycobacterium bovis BCG str. Pasteur 1173P2 4698246 YP_979325.1 CDS gpm2_1 NC_008769.1 3544128 3544739 D forms a homodimer in Mycobacterium tuberculosis; belongs to the dPGM superfamily; acid phosphatase 3544128..3544739 Mycobacterium bovis BCG str. Pasteur 1173P2 4698231 YP_979326.1 CDS entC_1 NC_008769.1 3544736 3545854 D isochorismate synthase entC 3544736..3545854 Mycobacterium bovis BCG str. Pasteur 1173P2 4697841 YP_979327.1 CDS BCG_3243 NC_008769.1 3546002 3546334 D acetyltransferase 3546002..3546334 Mycobacterium bovis BCG str. Pasteur 1173P2 4697924 YP_979328.1 CDS BCG_3244c NC_008769.1 3546286 3546717 R integral membrane protein complement(3546286..3546717) Mycobacterium bovis BCG str. Pasteur 1173P2 4698887 YP_979329.1 CDS BCG_3245 NC_008769.1 3546950 3547915 D hypothetical protein 3546950..3547915 Mycobacterium bovis BCG str. Pasteur 1173P2 4698247 YP_979330.1 CDS whiB1_1 NC_008769.1 3548195 3548449 D transcriptional regulatory protein whiB-like whiB1 3548195..3548449 Mycobacterium bovis BCG str. Pasteur 1173P2 4698039 YP_979331.1 CDS BCG_3247c NC_008769.1 3548511 3550016 R Differs from Rv3220c by 1aa, N47D; two component sensor kinase complement(3548511..3550016) Mycobacterium bovis BCG str. Pasteur 1173P2 4695497 YP_979332.1 CDS TB7.3_1 NC_008769.1 3550033 3550248 R acetyl-CoA carboxylase biotin carboxyl carrier protein subunit complement(3550033..3550248) Mycobacterium bovis BCG str. Pasteur 1173P2 4698146 YP_979333.1 CDS BCG_3249c NC_008769.1 3550533 3550838 R anti-sigma factor complement(3550533..3550838) Mycobacterium bovis BCG str. Pasteur 1173P2 4696425 YP_979334.1 CDS BCG_3250c NC_008769.1 3550835 3551386 R hypothetical protein complement(3550835..3551386) Mycobacterium bovis BCG str. Pasteur 1173P2 4698125 YP_979335.1 CDS sigH_1 NC_008769.1 3551383 3552033 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE complement(3551383..3552033) Mycobacterium bovis BCG str. Pasteur 1173P2 4698266 YP_979336.1 CDS BCG_3252 NC_008769.1 3552333 3553181 D short chain dehydrogenase 3552333..3553181 Mycobacterium bovis BCG str. Pasteur 1173P2 4695355 YP_979337.1 CDS BCG_3253 NC_008769.1 3553117 3553305 D hypothetical protein 3553117..3553305 Mycobacterium bovis BCG str. Pasteur 1173P2 4698380 YP_979338.1 CDS BCG_3254 NC_008769.1 3553283 3553501 D hypothetical protein 3553283..3553501 Mycobacterium bovis BCG str. Pasteur 1173P2 4699265 YP_979339.1 CDS BCG_3255c NC_008769.1 3553498 3554922 R Differs from Rv3225c by 1aa T306A; transferase complement(3553498..3554922) Mycobacterium bovis BCG str. Pasteur 1173P2 4698200 YP_979340.1 CDS BCG_3256c NC_008769.1 3555046 3555804 R hypothetical protein complement(3555046..3555804) Mycobacterium bovis BCG str. Pasteur 1173P2 4699348 YP_979341.1 CDS aroA_1 NC_008769.1 3555859 3557211 D catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 3555859..3557211 Mycobacterium bovis BCG str. Pasteur 1173P2 4698762 YP_979342.1 CDS BCG_3258 NC_008769.1 3557208 3558200 D Differs from Rv3228, Mb3257 and BCG_3351 by 1aa, D169G; hypothetical protein 3557208..3558200 Mycobacterium bovis BCG str. Pasteur 1173P2 4698765 YP_979343.1 CDS desA3_1 NC_008769.1 3558233 3559516 R linoleoyl-CoA desaturase complement(3558233..3559516) Mycobacterium bovis BCG str. Pasteur 1173P2 4699317 YP_979344.1 CDS BCG_3260c NC_008769.1 3559594 3560736 R Differs from Rv3230c by 1aa, C105R; oxidoreductase complement(3559594..3560736) Mycobacterium bovis BCG str. Pasteur 1173P2 4696176 YP_979345.1 CDS BCG_3261c NC_008769.1 3560846 3561355 R IN DU2, the second copy (BCG_3355c) is truncated; hypothetical protein complement(3560846..3561355) Mycobacterium bovis BCG str. Pasteur 1173P2 4698625 YP_979346.1 CDS pvdS NC_008769.1 3561352 3562239 R transcriptional regulatory protein pvdS complement(3561352..3562239) Mycobacterium bovis BCG str. Pasteur 1173P2 4699187 YP_979347.1 CDS BCG_3263c NC_008769.1 3562263 3563672 R In Mycobacterium tuberculosis H37Rv, Rv3234c and Rv3233c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-g) leads to a single product that is more similar to Rv3234c; hypothetical protein complement(3562263..3563672) Mycobacterium bovis BCG str. Pasteur 1173P2 4696881 YP_979348.1 CDS BCG_3264 NC_008769.1 3563783 3564424 D hypothetical protein 3563783..3564424 Mycobacterium bovis BCG str. Pasteur 1173P2 4698677 YP_979349.1 CDS BCG_3265c NC_008769.1 3564442 3565599 R integral membrane transport protein complement(3564442..3565599) Mycobacterium bovis BCG str. Pasteur 1173P2 4698989 YP_979350.1 CDS BCG_3266c NC_008769.1 3565604 3566086 R hypothetical protein complement(3565604..3566086) Mycobacterium bovis BCG str. Pasteur 1173P2 4698341 YP_979351.1 CDS BCG_3267c NC_008769.1 3566147 3566881 R integral membrane protein complement(3566147..3566881) Mycobacterium bovis BCG str. Pasteur 1173P2 4699025 YP_979352.1 CDS BCG_3268c NC_008769.1 3566940 3570086 R Differs from Mb3267c by 1aa, R867H; transmembrane transport protein complement(3566940..3570086) Mycobacterium bovis BCG str. Pasteur 1173P2 4698984 YP_979353.1 CDS secA1 NC_008769.1 3570165 3573014 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(3570165..3573014) Mycobacterium bovis BCG str. Pasteur 1173P2 4698500 YP_979354.1 CDS BCG_3270c NC_008769.1 3573093 3573737 R hypothetical protein complement(3573093..3573737) Mycobacterium bovis BCG str. Pasteur 1173P2 4697250 YP_979355.1 CDS BCG_3271c NC_008769.1 3574053 3574694 R Differs from Rv3242c and Mb3270c by 1aa, S89L; hypothetical protein complement(3574053..3574694) Mycobacterium bovis BCG str. Pasteur 1173P2 4699061 YP_979356.1 CDS BCG_3272c NC_008769.1 3574732 3575574 R hypothetical protein complement(3574732..3575574) Mycobacterium bovis BCG str. Pasteur 1173P2 4698515 YP_979357.1 CDS lpqB NC_008769.1 3575642 3577393 R Differs from Rv3244c by 2aa, G142D, L394S; lipoprotein LpqB complement(3575642..3577393) Mycobacterium bovis BCG str. Pasteur 1173P2 4699297 YP_979358.1 CDS mtrB NC_008769.1 3577393 3579096 R Differs from Rv3245c by 1aa, L517M; two component sensory transduction histidine kinase mtrB complement(3577393..3579096) Mycobacterium bovis BCG str. Pasteur 1173P2 4698617 YP_979359.1 CDS mtrA NC_008769.1 3579146 3579832 R two component sensory transduction transcriptional regulatory protein mtrA complement(3579146..3579832) Mycobacterium bovis BCG str. Pasteur 1173P2 4699150 YP_979360.1 CDS tmk NC_008769.1 3579902 3580546 R catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase complement(3579902..3580546) Mycobacterium bovis BCG str. Pasteur 1173P2 4699149 YP_979361.1 CDS sahH NC_008769.1 3580643 3582130 R catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase complement(3580643..3582130) Mycobacterium bovis BCG str. Pasteur 1173P2 4696387 YP_979362.1 CDS BCG_3278c NC_008769.1 3582235 3582870 R TetR family transcriptional regulator complement(3582235..3582870) Mycobacterium bovis BCG str. Pasteur 1173P2 4697894 YP_979363.1 CDS BCG_3279c NC_008769.1 3582867 3583049 R rubredoxin rubB complement(3582867..3583049) Mycobacterium bovis BCG str. Pasteur 1173P2 4698475 YP_979364.1 CDS BCG_3280c NC_008769.1 3583054 3583221 R rubredoxin rubA complement(3583054..3583221) Mycobacterium bovis BCG str. Pasteur 1173P2 4698965 YP_979365.1 CDS alkB NC_008769.1 3583221 3584471 R transmembrane alkane 1-monooxygenase alkB complement(3583221..3584471) Mycobacterium bovis BCG str. Pasteur 1173P2 4698539 YP_979366.1 CDS BCG_3282c NC_008769.1 3584580 3586067 R cationic amino acid transport integral membrane protein complement(3584580..3586067) Mycobacterium bovis BCG str. Pasteur 1173P2 4696195 YP_979367.1 CDS BCG_3283 NC_008769.1 3586158 3587546 D hypothetical protein 3586158..3587546 Mycobacterium bovis BCG str. Pasteur 1173P2 4698876 YP_979368.1 CDS manA NC_008769.1 3587524 3588750 R mannose-6-phosphate isomerase manA complement(3587524..3588750) Mycobacterium bovis BCG str. Pasteur 1173P2 4698815 YP_979369.1 CDS BCG_3285c NC_008769.1 3588758 3589798 R hypothetical protein complement(3588758..3589798) Mycobacterium bovis BCG str. Pasteur 1173P2 4698308 YP_979370.1 CDS manB NC_008769.1 3589795 3591192 R converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells; phosphomannomutase complement(3589795..3591192) Mycobacterium bovis BCG str. Pasteur 1173P2 4698271 YP_979371.1 CDS BCG_3287c NC_008769.1 3591294 3591785 R hypothetical protein complement(3591294..3591785) Mycobacterium bovis BCG str. Pasteur 1173P2 4698309 YP_979372.1 CDS BCG_3288 NC_008769.1 3591908 3592327 D hypothetical protein 3591908..3592327 Mycobacterium bovis BCG str. Pasteur 1173P2 4698235 YP_979373.1 CDS whiB2 NC_008769.1 3592355 3592624 R transcriptional regulatory protein whiB-like whiB2 complement(3592355..3592624) Mycobacterium bovis BCG str. Pasteur 1173P2 4698199 YP_979374.1 CDS fbiA NC_008769.1 3593026 3594021 D catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); LPPG:FO 2-phospho-L-lactate transferase 3593026..3594021 Mycobacterium bovis BCG str. Pasteur 1173P2 4695499 YP_979375.1 CDS fbiB NC_008769.1 3594018 3595364 D catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0); F420-0--gamma-glutamyl ligase 3594018..3595364 Mycobacterium bovis BCG str. Pasteur 1173P2 4696561 YP_979376.1 CDS BCG_3292 NC_008769.1 3595660 3597321 D DNA methylase 3595660..3597321 Mycobacterium bovis BCG str. Pasteur 1173P2 4696562 YP_979377.1 CDS manC NC_008769.1 3597381 3598460 R mannose-1-phosphate guanyltransferase manC complement(3597381..3598460) Mycobacterium bovis BCG str. Pasteur 1173P2 4696035 YP_979378.1 CDS wbbL1 NC_008769.1 3598462 3599355 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, an in-frame deletion of 12 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (297 aa versus 301 aa); dTDP-RHA:A-D-GlcNAc-diphosphoryl polyprenol, A-3-L-rhamnosyl transferase wbbL1 complement(3598462..3599355) Mycobacterium bovis BCG str. Pasteur 1173P2 4698310 YP_979379.1 CDS rmld NC_008769.1 3599366 3600280 R Differs from Rv3266c by 1aa, P257S; dTDP-rhamnose modification protein rmlD complement(3599366..3600280) Mycobacterium bovis BCG str. Pasteur 1173P2 4697891 YP_979380.1 CDS BCG_3296 NC_008769.1 3600356 3601852 D hypothetical protein 3600356..3601852 Mycobacterium bovis BCG str. Pasteur 1173P2 4697605 YP_979381.1 CDS BCG_3297 NC_008769.1 3601891 3602580 D hypothetical protein 3601891..3602580 Mycobacterium bovis BCG str. Pasteur 1173P2 4698490 YP_979382.1 CDS BCG_3298 NC_008769.1 3602705 3602986 D hypothetical protein 3602705..3602986 Mycobacterium bovis BCG str. Pasteur 1173P2 4698710 YP_979383.1 CDS ctpC NC_008769.1 3602997 3605153 D metal cation-transporting P-type atpase C ctpC 3602997..3605153 Mycobacterium bovis BCG str. Pasteur 1173P2 4699346 YP_979384.1 CDS BCG_3300c NC_008769.1 3605150 3605818 R integral membrane protein complement(3605150..3605818) Mycobacterium bovis BCG str. Pasteur 1173P2 4697501 YP_979385.1 CDS BCG_3301 NC_008769.1 3605919 3607103 D Differs from Mb3300 by 1aa, R259G, and from Rv3272 by 2aa, R259G, S347N; hypothetical protein 3605919..3607103 Mycobacterium bovis BCG str. Pasteur 1173P2 4698970 YP_979386.1 CDS BCG_3302 NC_008769.1 3607108 3609402 D transmembrane carbonic anhydrase 3607108..3609402 Mycobacterium bovis BCG str. Pasteur 1173P2 4699109 YP_979387.1 CDS fadE25 NC_008769.1 3609391 3610560 R acyl-CoA dehydrogenase fadE25 complement(3609391..3610560) Mycobacterium bovis BCG str. Pasteur 1173P2 4698979 YP_979388.1 CDS purE NC_008769.1 3610585 3611109 R Differs from Rv3275c by 1aa, R125G; phosphoribosylaminoimidazole carboxylase catalytic subunit purE complement(3610585..3611109) Mycobacterium bovis BCG str. Pasteur 1173P2 4697413 YP_979389.1 CDS purK NC_008769.1 3611106 3612395 R With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit complement(3611106..3612395) Mycobacterium bovis BCG str. Pasteur 1173P2 4696431 YP_979390.1 CDS BCG_3306 NC_008769.1 3612349 3613167 D Differs from Rv3277 by 1 aa, L272S; hypothetical protein 3612349..3613167 Mycobacterium bovis BCG str. Pasteur 1173P2 4696434 YP_979391.1 CDS BCG_3307c NC_008769.1 3613122 3613640 R Differs from Rv3278c by 1aa, K160E; hypothetical protein complement(3613122..3613640) Mycobacterium bovis BCG str. Pasteur 1173P2 4698407 YP_979392.1 CDS birA NC_008769.1 3613683 3614483 R Differs from Rv3279c by 1aa, N211D; bifunctional protein birA: biotin operon repressor + biotin--[acetyl-coa-carboxylase] synthetase complement(3613683..3614483) Mycobacterium bovis BCG str. Pasteur 1173P2 4698074 YP_979393.1 CDS accD5 NC_008769.1 3614533 3616179 D Differs from Rv3280 by 1aa, A448V; propionyl-CoA carboxylase beta chain 5 accD5 3614533..3616179 Mycobacterium bovis BCG str. Pasteur 1173P2 4696128 YP_979394.1 CDS BCG_3310 NC_008769.1 3616160 3616630 D In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, an in-frame deletion of 63 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (156 aa versus 177 aa). Loss of tandem repeat SRVSGTNEVSDGNETNNPAPV; hypothetical protein 3616160..3616630 Mycobacterium bovis BCG str. Pasteur 1173P2 4698862 YP_979395.1 CDS BCG_3311 NC_008769.1 3616627 3617295 D Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 3616627..3617295 Mycobacterium bovis BCG str. Pasteur 1173P2 4698263 YP_979396.1 CDS sseA NC_008769.1 3617336 3618229 D Differs from Mb3311 by 1aa, G170D; thiosulfate sulfurtransferase sseA 3617336..3618229 Mycobacterium bovis BCG str. Pasteur 1173P2 4699030 YP_979397.1 CDS BCG_3313 NC_008769.1 3618226 3618657 D hypothetical protein 3618226..3618657 Mycobacterium bovis BCG str. Pasteur 1173P2 4696753 YP_979398.1 CDS accA3 NC_008769.1 3618765 3620567 D bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (alpha chain) accA3: biotin carboxylase + biotin carboxyl carrier protein 3618765..3620567 Mycobacterium bovis BCG str. Pasteur 1173P2 4699098 YP_979399.1 CDS sigF NC_008769.1 3620577 3621362 R Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is a general stress response regulator; expressed in stationary phase and under nitrogen depletion and cold shock; RNA polymerase sigma factor SigF complement(3620577..3621362) Mycobacterium bovis BCG str. Pasteur 1173P2 4698702 YP_979400.1 CDS rsbW NC_008769.1 3621359 3621796 R anti-sigma factor rsbW complement(3621359..3621796) Mycobacterium bovis BCG str. Pasteur 1173P2 4695818 YP_979401.1 CDS usfY NC_008769.1 3621994 3622407 R protein usfY complement(3621994..3622407) Mycobacterium bovis BCG str. Pasteur 1173P2 4697805 YP_979402.1 CDS BCG_3318c NC_008769.1 3622442 3622819 R hypothetical protein complement(3622442..3622819) Mycobacterium bovis BCG str. Pasteur 1173P2 4695769 YP_979403.1 CDS lat NC_008769.1 3622853 3624202 R catalyzes the formation of 2-aminoadipate 6-semiladehyde and glutamate from lysine and 2-oxoglutarate; L-lysine aminotransferase complement(3622853..3624202) Mycobacterium bovis BCG str. Pasteur 1173P2 4698878 YP_979404.1 CDS BCG_3320c NC_008769.1 3624253 3624705 R Differs from Rv3291c by 1aa, V22A; AsnC family transcriptional regulator complement(3624253..3624705) Mycobacterium bovis BCG str. Pasteur 1173P2 4695954 YP_979405.1 CDS BCG_3321 NC_008769.1 3624736 3625983 D hypothetical protein 3624736..3625983 Mycobacterium bovis BCG str. Pasteur 1173P2 4698957 YP_979406.1 CDS pcd_1 NC_008769.1 3626010 3627494 D Differs from Rv3293 by 1aa, C273G; piperideine-6-carboxilic acid dehydrogenase pcd 3626010..3627494 Mycobacterium bovis BCG str. Pasteur 1173P2 4698806 YP_979407.1 CDS BCG_3323c NC_008769.1 3627594 3628403 R hypothetical protein complement(3627594..3628403) Mycobacterium bovis BCG str. Pasteur 1173P2 4698837 YP_979408.1 CDS BCG_3324 NC_008769.1 3628474 3629139 D TetR family transcriptional regulator 3628474..3629139 Mycobacterium bovis BCG str. Pasteur 1173P2 4698667 YP_979409.1 CDS lhr_1 NC_008769.1 3629183 3633724 D Differs from Rv3296 by 3aa, M719V, N818D, E1059K; ATP-dependent helicase lhr 3629183..3633724 Mycobacterium bovis BCG str. Pasteur 1173P2 4699268 YP_979410.1 CDS nei_1 NC_008769.1 3633728 3634495 D endonuclease VIII nei 3633728..3634495 Mycobacterium bovis BCG str. Pasteur 1173P2 4697270 YP_979411.1 CDS lpqC_1 NC_008769.1 3634518 3635432 R esterase lipoprotein lpqC complement(3634518..3635432) Mycobacterium bovis BCG str. Pasteur 1173P2 4696140 YP_979412.1 CDS atsB NC_008769.1 3635459 3638371 R Differs from Rv3299c by 1aa, S204G; arylsulfatase atsB complement(3635459..3638371) Mycobacterium bovis BCG str. Pasteur 1173P2 4696105 YP_979413.1 CDS BCG_3329c NC_008769.1 3638391 3639308 R Differs from Mb3328c by 1aa, D52N; hypothetical protein complement(3638391..3639308) Mycobacterium bovis BCG str. Pasteur 1173P2 4698657 YP_979414.1 CDS phoY1_1 NC_008769.1 3639320 3639985 R Differs from Rv3301c and Mb3329c by 1aa, S74A; phosphate-transport system transcriptional regulatory protein phoU 1 phoY1 complement(3639320..3639985) Mycobacterium bovis BCG str. Pasteur 1173P2 4699211 YP_979415.1 CDS glpD2_1 NC_008769.1 3640093 3641850 R glycerol-3-phosphate dehydrogenase glpD2 complement(3640093..3641850) Mycobacterium bovis BCG str. Pasteur 1173P2 4698181 YP_979416.1 CDS BCG_3333c NC_008769.1 3642530 3643126 R In Mycobacterium bovis BCG Pasteur, Mb3333c is truncated compared to its homologs in Mycobacterium tuberculosis strain H37Rv (Rv3213c) and Mycobacterium bovis AF2122/97 (Mb3239c). It contains one endpoint of BCG-specific tandem duplication region, DU2. Differs from Rv3213c by 2aa, E144K and P198L; soj/parA-related protein complement(3642530..3643126) Mycobacterium bovis BCG str. Pasteur 1173P2 4698637 YP_979417.1 CDS gpm2_2 NC_008769.1 3643280 3643891 D forms a homodimer in Mycobacterium tuberculosis; belongs to the dPGM superfamily; acid phosphatase 3643280..3643891 Mycobacterium bovis BCG str. Pasteur 1173P2 4698360 YP_979418.1 CDS entC_2 NC_008769.1 3643888 3645006 D isochorismate synthase entC 3643888..3645006 Mycobacterium bovis BCG str. Pasteur 1173P2 4697842 YP_979419.1 CDS BCG_3336 NC_008769.1 3645154 3645486 D acetyltransferase 3645154..3645486 Mycobacterium bovis BCG str. Pasteur 1173P2 4699016 YP_979420.1 CDS BCG_3337c NC_008769.1 3645438 3645869 R integral membrane protein complement(3645438..3645869) Mycobacterium bovis BCG str. Pasteur 1173P2 4698510 YP_979421.1 CDS BCG_3338 NC_008769.1 3646102 3647067 D hypothetical protein 3646102..3647067 Mycobacterium bovis BCG str. Pasteur 1173P2 4698694 YP_979422.1 CDS whiB1_2 NC_008769.1 3647347 3647601 D transcriptional regulatory protein whiB-like whiB1 3647347..3647601 Mycobacterium bovis BCG str. Pasteur 1173P2 4698449 YP_979423.1 CDS BCG_3340c NC_008769.1 3647663 3649168 R Differs from Rv3220c by 1aa, N47D; two component sensor kinase complement(3647663..3649168) Mycobacterium bovis BCG str. Pasteur 1173P2 4695498 YP_979424.1 CDS TB7.3_2 NC_008769.1 3649185 3649400 R acetyl-CoA carboxylase biotin carboxyl carrier protein subunit complement(3649185..3649400) Mycobacterium bovis BCG str. Pasteur 1173P2 4698186 YP_979425.1 CDS BCG_3342c NC_008769.1 3649685 3649990 R anti-sigma factor complement(3649685..3649990) Mycobacterium bovis BCG str. Pasteur 1173P2 4696426 YP_979426.1 CDS BCG_3343c NC_008769.1 3649987 3650538 R hypothetical protein complement(3649987..3650538) Mycobacterium bovis BCG str. Pasteur 1173P2 4699053 YP_979427.1 CDS sigH_2 NC_008769.1 3650535 3651185 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE complement(3650535..3651185) Mycobacterium bovis BCG str. Pasteur 1173P2 4698719 YP_979428.1 CDS BCG_3345 NC_008769.1 3651485 3652333 D short chain dehydrogenase 3651485..3652333 Mycobacterium bovis BCG str. Pasteur 1173P2 4695356 YP_979429.1 CDS BCG_3346 NC_008769.1 3652269 3652457 D hypothetical protein 3652269..3652457 Mycobacterium bovis BCG str. Pasteur 1173P2 4698516 YP_979430.1 CDS BCG_3347 NC_008769.1 3652435 3652653 D hypothetical protein 3652435..3652653 Mycobacterium bovis BCG str. Pasteur 1173P2 4699258 YP_979431.1 CDS BCG_3348c NC_008769.1 3652650 3654074 R Differs from Rv3225c by 1aa, T305A; transferase complement(3652650..3654074) Mycobacterium bovis BCG str. Pasteur 1173P2 4699023 YP_979432.1 CDS BCG_3349c NC_008769.1 3654198 3654956 R hypothetical protein complement(3654198..3654956) Mycobacterium bovis BCG str. Pasteur 1173P2 4698314 YP_979433.1 CDS aroA_2 NC_008769.1 3655011 3656363 D catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 3655011..3656363 Mycobacterium bovis BCG str. Pasteur 1173P2 4698554 YP_979434.1 CDS BCG_3351 NC_008769.1 3656360 3657352 D Differs from BCG_3258 by 1aa, G169D; hypothetical protein 3656360..3657352 Mycobacterium bovis BCG str. Pasteur 1173P2 4695659 YP_979435.1 CDS desA3_2 NC_008769.1 3657385 3658668 R linoleoyl-CoA desaturase desA3 complement(3657385..3658668) Mycobacterium bovis BCG str. Pasteur 1173P2 4698918 YP_979436.1 CDS BCG_3353c NC_008769.1 3658746 3659888 R Differs from Rv3230c by 1aa, C105R; oxidoreductase complement(3658746..3659888) Mycobacterium bovis BCG str. Pasteur 1173P2 4698005 YP_979437.1 CDS lat' NC_008769.1 3659943 3660365 R Internal deletion of DU2 leads to a truncated copy of Rv3231c and of Rv3290c; L-lysine-epsilon aminotransferase lat' complement(3659943..3660365) Mycobacterium bovis BCG str. Pasteur 1173P2 4699046 YP_979438.1 CDS BCG_3356c NC_008769.1 3660416 3660868 R Differs from Rv3291c by 1aa, V22A; AsnC family transcriptional regulator complement(3660416..3660868) Mycobacterium bovis BCG str. Pasteur 1173P2 4695955 YP_979439.1 CDS BCG_3357 NC_008769.1 3660899 3662146 D hypothetical protein 3660899..3662146 Mycobacterium bovis BCG str. Pasteur 1173P2 4699332 YP_979440.1 CDS pcd_2 NC_008769.1 3662173 3663657 D Differs from Rv3293 by 1aa, C273G; piperideine-6-carboxilic acid dehydrogenase pcd 3662173..3663657 Mycobacterium bovis BCG str. Pasteur 1173P2 4699282 YP_979441.1 CDS BCG_3359c NC_008769.1 3663757 3664566 R hypothetical protein complement(3663757..3664566) Mycobacterium bovis BCG str. Pasteur 1173P2 4698417 YP_979442.1 CDS BCG_3360 NC_008769.1 3664637 3665302 D TetR family transcriptional regulator 3664637..3665302 Mycobacterium bovis BCG str. Pasteur 1173P2 4698378 YP_979443.1 CDS lhr_2 NC_008769.1 3665346 3669887 D Differs from Rv3296 by 3aa, M719V, N818D, E1059K; atp-dependent helicase lhr 3665346..3669887 Mycobacterium bovis BCG str. Pasteur 1173P2 4698521 YP_979444.1 CDS nei_2 NC_008769.1 3669891 3670658 D endonuclease VIII nei 3669891..3670658 Mycobacterium bovis BCG str. Pasteur 1173P2 4697271 YP_979445.1 CDS lpqC_2 NC_008769.1 3670681 3671595 R esterase lipoprotein lpqC complement(3670681..3671595) Mycobacterium bovis BCG str. Pasteur 1173P2 4699203 YP_979446.1 CDS atsB_2 NC_008769.1 3671622 3674534 R Differs from Rv3299c by 1aa, S204G; arylsulfatase atsB complement(3671622..3674534) Mycobacterium bovis BCG str. Pasteur 1173P2 4696106 YP_979447.1 CDS BCG_3365c NC_008769.1 3674554 3675471 R Differs from Mb3328c by 1aa, D52N; hypothetical protein complement(3674554..3675471) Mycobacterium bovis BCG str. Pasteur 1173P2 4695704 YP_979448.1 CDS phoY1_2 NC_008769.1 3675483 3676148 R Differs from Rv3301c and Mb3329c by 1aa, S74A; phosphate-transport system transcriptional regulatory protein phoU 1 phoY1 complement(3675483..3676148) Mycobacterium bovis BCG str. Pasteur 1173P2 4699156 YP_979449.1 CDS glpD2_2 NC_008769.1 3676256 3678013 R glycerol-3-phosphate dehydrogenase glpD2 complement(3676256..3678013) Mycobacterium bovis BCG str. Pasteur 1173P2 4698182 YP_979450.1 CDS lpdA NC_008769.1 3678094 3679509 R catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; flavoprotein disulfide reductase complement(3678094..3679509) Mycobacterium bovis BCG str. Pasteur 1173P2 4697770 YP_979451.1 CDS BCG_3369 NC_008769.1 3679712 3680191 D hypothetical protein 3679712..3680191 Mycobacterium bovis BCG str. Pasteur 1173P2 4699198 YP_979452.1 CDS amiA1 NC_008769.1 3680210 3681379 R N-acyl-L-amino acid amidohydrolase amiA1 complement(3680210..3681379) Mycobacterium bovis BCG str. Pasteur 1173P2 4699033 YP_979453.1 CDS amiB1 NC_008769.1 3681376 3682560 R amidase amiB1 complement(3681376..3682560) Mycobacterium bovis BCG str. Pasteur 1173P2 4696149 YP_979454.1 CDS deoD NC_008769.1 3682625 3683431 D catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 3682625..3683431 Mycobacterium bovis BCG str. Pasteur 1173P2 4696234 YP_979455.1 CDS pmmB NC_008769.1 3683435 3685039 D Differs from Rv3308 by 1aa, G440S; phosphomannomutase pmmB 3683435..3685039 Mycobacterium bovis BCG str. Pasteur 1173P2 4698848 YP_979456.1 CDS upp NC_008769.1 3685041 3685664 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(3685041..3685664) Mycobacterium bovis BCG str. Pasteur 1173P2 4696814 YP_979457.1 CDS sapM NC_008769.1 3685769 3686668 D Differs from Rv3310 by 1aa, A171T; acid phosphatase 3685769..3686668 Mycobacterium bovis BCG str. Pasteur 1173P2 4696502 YP_979458.1 CDS BCG_3376 NC_008769.1 3686692 3687954 D hypothetical protein 3686692..3687954 Mycobacterium bovis BCG str. Pasteur 1173P2 4697895 YP_979459.1 CDS BCG_3377c NC_008769.1 3687975 3688901 R hypothetical protein complement(3687975..3688901) Mycobacterium bovis BCG str. Pasteur 1173P2 4699032 YP_979460.1 CDS BCG_3378c NC_008769.1 3689276 3689587 R hypothetical protein complement(3689276..3689587) Mycobacterium bovis BCG str. Pasteur 1173P2 4698338 YP_979461.1 CDS add NC_008769.1 3689658 3690755 R catalyzes the formation of inosine from adenosine; adenosine deaminase complement(3689658..3690755) Mycobacterium bovis BCG str. Pasteur 1173P2 4698245 YP_979462.1 CDS deoA NC_008769.1 3690755 3692038 R Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase complement(3690755..3692038) Mycobacterium bovis BCG str. Pasteur 1173P2 4697885 YP_979463.1 CDS cdd NC_008769.1 3692035 3692436 R Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase complement(3692035..3692436) Mycobacterium bovis BCG str. Pasteur 1173P2 4696742 YP_979464.1 CDS sdhC NC_008769.1 3692673 3693011 D succinate dehydrogenase (cytochrome B-556 subunit) SDHC 3692673..3693011 Mycobacterium bovis BCG str. Pasteur 1173P2 4697614 YP_979465.1 CDS sdhD NC_008769.1 3693008 3693442 D Differs from Rv3317 by 1aa, L54V; succinate dehydrogenase (hydrophobic membrane anchor subunit) sdhD 3693008..3693442 Mycobacterium bovis BCG str. Pasteur 1173P2 4697248 YP_979466.1 CDS sdhA NC_008769.1 3693571 3695343 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 3693571..3695343 Mycobacterium bovis BCG str. Pasteur 1173P2 4697249 YP_979467.1 CDS sdhB NC_008769.1 3695343 3696134 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 3695343..3696134 Mycobacterium bovis BCG str. Pasteur 1173P2 4697246 YP_979468.1 CDS BCG_3386c NC_008769.1 3696213 3696641 R hypothetical protein complement(3696213..3696641) Mycobacterium bovis BCG str. Pasteur 1173P2 4697247 YP_979469.1 CDS BCG_3387c NC_008769.1 3696645 3696887 R hypothetical protein complement(3696645..3696887) Mycobacterium bovis BCG str. Pasteur 1173P2 4698894 YP_979470.1 CDS BCG_3388c NC_008769.1 3697009 3697623 R methyltransferase complement(3697009..3697623) Mycobacterium bovis BCG str. Pasteur 1173P2 4698034 YP_979471.1 CDS moaX NC_008769.1 3697620 3698285 R moaD-moaE fusion protein moaX complement(3697620..3698285) Mycobacterium bovis BCG str. Pasteur 1173P2 4698884 YP_979472.1 CDS moaC NC_008769.1 3698286 3698819 R MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC complement(3698286..3698819) Mycobacterium bovis BCG str. Pasteur 1173P2 4698497 YP_979473.1 CDS moaB3 NC_008769.1 3698816 3699190 R Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv; pterin-4-alpha-carbinolamine dehydratase moaB3 complement(3698816..3699190) Mycobacterium bovis BCG str. Pasteur 1173P2 4698493 YP_979474.1 CDS moaA3 NC_008769.1 3699287 3700351 R Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv; molybdenum cofactor biosynthesis protein A moaA1 complement(3699287..3700351) Mycobacterium bovis BCG str. Pasteur 1173P2 4695604 YP_979475.1 CDS BCG_3393 NC_008769.1 3700406 3700756 D Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv but present in CDC1551 (CDS not annotated); hypothetical protein 3700406..3700756 Mycobacterium bovis BCG str. Pasteur 1173P2 4698508 YP_979476.1 CDS BCG_3394 NC_008769.1 3700734 3701120 D Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv but present in CDC1551 (CDS not annotated); hypothetical protein 3700734..3701120 Mycobacterium bovis BCG str. Pasteur 1173P2 4698599 YP_979477.1 CDS embR2 NC_008769.1 3700996 3702141 D Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv; transcriptional regulatory protein embR2 3700996..3702141 Mycobacterium bovis BCG str. Pasteur 1173P2 4699240 YP_979478.1 CDS BCG_3396c NC_008769.1 3702236 3702880 R Belongs to the RvD5 region. Absent from Mycobacterium tuberculosis strain H37Rv; hypothetical protein complement(3702236..3702880) Mycobacterium bovis BCG str. Pasteur 1173P2 4697917 YP_979479.1 CDS BCG_3397 NC_008769.1 3703047 3704759 D transposase fusion protein 3703047..3704759 Mycobacterium bovis BCG str. Pasteur 1173P2 4698172 YP_979480.1 CDS sigJ NC_008769.1 3704692 3705630 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigJ complement(3704692..3705630) Mycobacterium bovis BCG str. Pasteur 1173P2 4698147 YP_979481.1 CDS BCG_3399 NC_008769.1 3705690 3707006 D Differs from Rv3329 by 1aa, H122Q; hypothetical protein 3705690..3707006 Mycobacterium bovis BCG str. Pasteur 1173P2 4695358 YP_979482.1 CDS dacB1 NC_008769.1 3707075 3708292 D penicillin-binding protein dacB1 3707075..3708292 Mycobacterium bovis BCG str. Pasteur 1173P2 4698538 YP_979483.1 CDS sugI NC_008769.1 3708388 3709881 D Differs from Mb3364 by 5aa in-frame deletion at position 465, and from Rv3331 by same deletion and 1aa, L423P; sugar-transport integral membrane protein sugI 3708388..3709881 Mycobacterium bovis BCG str. Pasteur 1173P2 4698666 YP_979484.1 CDS nagA NC_008769.1 3709878 3711029 D N-acetylglucosamine-6-phosphate deacetylase nagA 3709878..3711029 Mycobacterium bovis BCG str. Pasteur 1173P2 4696335 YP_979485.1 CDS BCG_3403c NC_008769.1 3711220 3712065 R hypothetical protein complement(3711220..3712065) Mycobacterium bovis BCG str. Pasteur 1173P2 4696617 YP_979486.1 CDS BCG_3404 NC_008769.1 3712210 3712521 D hypothetical protein 3712210..3712521 Mycobacterium bovis BCG str. Pasteur 1173P2 4699100 YP_979487.1 CDS BCG_3405 NC_008769.1 3712540 3712980 D MerR family transcriptional regulator 3712540..3712980 Mycobacterium bovis BCG str. Pasteur 1173P2 4698244 YP_979488.1 CDS BCG_3406c NC_008769.1 3713014 3713883 R Differs from Rv3335c and Mb3368c by 1aa, V86A; integral membrane protein complement(3713014..3713883) Mycobacterium bovis BCG str. Pasteur 1173P2 4698618 YP_979489.1 CDS trpS NC_008769.1 3713904 3714914 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(3713904..3714914) Mycobacterium bovis BCG str. Pasteur 1173P2 4699067 YP_979490.1 CDS BCG_3408 NC_008769.1 3714939 3715832 D In Mycobacterium tuberculosis strain H37Rv, Rv3337 and Rv3338 exist as 2 genes with an overlap region between them. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base insertion (*-t) leads to a single product; hypothetical protein 3714939..3715832 Mycobacterium bovis BCG str. Pasteur 1173P2 4695830 YP_979491.1 CDS icd1 NC_008769.1 3715899 3717128 R Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase complement(3715899..3717128) Mycobacterium bovis BCG str. Pasteur 1173P2 4699019 YP_979492.1 CDS metC NC_008769.1 3717411 3718760 D catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; O-acetylhomoserine aminocarboxypropyltransferase 3717411..3718760 Mycobacterium bovis BCG str. Pasteur 1173P2 4699213 YP_979493.1 CDS metX NC_008769.1 3718772 3719911 D Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase 3718772..3719911 Mycobacterium bovis BCG str. Pasteur 1173P2 4698210 YP_979494.1 CDS BCG_3412 NC_008769.1 3719908 3720639 D methyltransferase 3719908..3720639 Mycobacterium bovis BCG str. Pasteur 1173P2 4698208 YP_979495.1 CDS PPE54 NC_008769.1 3720648 3724664 R In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a 3555 bp in-frame deletion (RD19) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Mb3375c by 1aa A514V and from Rv3343c by several transitions; PPE family protein complement(3720648..3724664) Mycobacterium bovis BCG str. Pasteur 1173P2 4698272 YP_979496.1 CDS PE_PGRS50 NC_008769.1 3724713 3730343 R In Mycobacterium tuberculosis strain H37Rv, PE_PGRS50 and PE_PGRS49 exists as a single gene. In Mycobacterium bovis, a single base deletion (g-*) splits PE_PGRS50 into 2 parts, PE_PGRS50a and PE_PGRS50b and a single base deletion (c-*) leads to PE_PGRS49 and PE_PGRS50b existing as a single product. In Mycobacterium bovis BCG Pasteur, the first deletion is absent leading to an uniq single gene comprising PE_PGRS50 and PE_PGRS49; hypothetical protein complement(3724713..3730343) Mycobacterium bovis BCG str. Pasteur 1173P2 4697663 YP_979497.1 CDS BCG_3415c NC_008769.1 3730767 3731024 R hypothetical protein complement(3730767..3731024) Mycobacterium bovis BCG str. Pasteur 1173P2 4695719 YP_979498.1 CDS PPE55a NC_008769.1 3734462 3740752 R In Mycobacterium tuberculosis strain H37Rv, PPE55 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits PPE55 into 2 parts, PPE55a and PPE55b. Differs from Rv3347c by many aa substitutions and from Mb3380c by 1 aa, P1089S; PPE family protein complement(3734462..3740752) Mycobacterium bovis BCG str. Pasteur 1173P2 4697665 YP_979499.1 CDS BCG_3418 NC_008769.1 3741332 3741823 D transposase 3741332..3741823 Mycobacterium bovis BCG str. Pasteur 1173P2 4697664 YP_979500.1 CDS BCG_3419c NC_008769.1 3741860 3742600 R transposase complement(3741860..3742600) Mycobacterium bovis BCG str. Pasteur 1173P2 4698610 YP_979501.1 CDS PPE56a NC_008769.1 3753359 3754657 R In Mycobacterium tuberculosis strain H37Rv, PPE56 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, 2 frameshifts due to single base transversion (c-a) and a single base deletion (g-*) splits PPE56 into 3 parts, PPE56a, PPE56b and PPE56d; Differs from Rv3350c and Mb3385c by 2aa deletion at position 291; PPE family protein complement(3753359..3754657) Mycobacterium bovis BCG str. Pasteur 1173P2 4697667 YP_979502.1 CDS BCG_3423c NC_008769.1 3754901 3755695 R hypothetical protein complement(3754901..3755695) Mycobacterium bovis BCG str. Pasteur 1173P2 4697666 YP_979503.1 CDS BCG_3424c NC_008769.1 3755777 3756148 R oxidoreductase complement(3755777..3756148) Mycobacterium bovis BCG str. Pasteur 1173P2 4699137 YP_979504.1 CDS BCG_3425c NC_008769.1 3756291 3756551 R hypothetical protein complement(3756291..3756551) Mycobacterium bovis BCG str. Pasteur 1173P2 4699343 YP_979505.1 CDS BCG_3426 NC_008769.1 3756666 3757055 D Differs from Rv3354 by 1aa, A112V; hypothetical protein 3756666..3757055 Mycobacterium bovis BCG str. Pasteur 1173P2 4699209 YP_979506.1 CDS BCG_3427c NC_008769.1 3757069 3757362 R hypothetical protein complement(3757069..3757362) Mycobacterium bovis BCG str. Pasteur 1173P2 4699021 YP_979507.1 CDS folD NC_008769.1 3757359 3758204 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(3757359..3758204) Mycobacterium bovis BCG str. Pasteur 1173P2 4698595 YP_979508.1 CDS BCG_3429 NC_008769.1 3758328 3758603 D hypothetical protein 3758328..3758603 Mycobacterium bovis BCG str. Pasteur 1173P2 4697988 YP_979509.1 CDS BCG_3430 NC_008769.1 3758600 3758857 D hypothetical protein 3758600..3758857 Mycobacterium bovis BCG str. Pasteur 1173P2 4698990 YP_979510.1 CDS BCG_3431 NC_008769.1 3758899 3760089 D oxidoreductase 3758899..3760089 Mycobacterium bovis BCG str. Pasteur 1173P2 4698498 YP_979511.1 CDS BCG_3432 NC_008769.1 3760206 3760574 D hypothetical protein 3760206..3760574 Mycobacterium bovis BCG str. Pasteur 1173P2 4698153 YP_979512.1 CDS BCG_3433c NC_008769.1 3760571 3761122 R hypothetical protein complement(3760571..3761122) Mycobacterium bovis BCG str. Pasteur 1173P2 4698865 YP_979513.1 CDS BCG_3434c NC_008769.1 3761129 3761710 R ATP/GTP-binding protein complement(3761129..3761710) Mycobacterium bovis BCG str. Pasteur 1173P2 4698994 YP_979514.1 CDS BCG_3435c NC_008769.1 3761691 3762059 R hypothetical protein complement(3761691..3762059) Mycobacterium bovis BCG str. Pasteur 1173P2 4699196 YP_979515.1 CDS BCG_3436c NC_008769.1 3762037 3762429 R Differs from Rv3364c and Mb3399c, by 1aa, L22P; hypothetical protein complement(3762037..3762429) Mycobacterium bovis BCG str. Pasteur 1173P2 4699154 YP_979516.1 CDS BCG_3437c NC_008769.1 3762426 3765056 R hypothetical protein complement(3762426..3765056) Mycobacterium bovis BCG str. Pasteur 1173P2 4698130 YP_979517.1 CDS spoU NC_008769.1 3765292 3765756 D tRNA/rRNA methylase spoU 3765292..3765756 Mycobacterium bovis BCG str. Pasteur 1173P2 4698810 YP_979518.1 CDS PE_PGRS51 NC_008769.1 3766123 3767898 D In Mycobacterium bovis, insertions of 105 bp and of 9 bp (*-ggcagcggt) lead to longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (626 aa versus 588 aa). In Mycobacterium bovis BCG Pasteur, there is no 105 bp insertion but the 9 bp insertion is present at codon 404. Differs also from Rv3367 by 1aa, S412G; PE-PGRS family protein 3766123..3767898 Mycobacterium bovis BCG str. Pasteur 1173P2 4695623 YP_979519.1 CDS BCG_3440c NC_008769.1 3767899 3768543 R oxidoreductase complement(3767899..3768543) Mycobacterium bovis BCG str. Pasteur 1173P2 4695720 YP_979520.1 CDS BCG_3441 NC_008769.1 3768542 3768976 D hypothetical protein 3768542..3768976 Mycobacterium bovis BCG str. Pasteur 1173P2 4698594 YP_979521.1 CDS dnaE2 NC_008769.1 3769065 3772304 R DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase.; error-prone DNA polymerase complement(3769065..3772304) Mycobacterium bovis BCG str. Pasteur 1173P2 4698238 YP_979522.1 CDS BCG_3443 NC_008769.1 3772496 3773836 D Differs from Rv3371 by 2aa, G339R, V368I; hypothetical protein 3772496..3773836 Mycobacterium bovis BCG str. Pasteur 1173P2 4697937 YP_979523.1 CDS otsB2 NC_008769.1 3773878 3775053 D trehalose 6-phosphate phosphatase otsB2 3773878..3775053 Mycobacterium bovis BCG str. Pasteur 1173P2 4698978 YP_979524.1 CDS echA18 NC_008769.1 3775290 3776180 D In Mycobacterium tuberculosis H37Rv, echA18 and echA18' exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transversion (t-g) leads to a single product; enoyl-CoA hydratase echA18 3775290..3776180 Mycobacterium bovis BCG str. Pasteur 1173P2 4698924 YP_979525.1 CDS amiD NC_008769.1 3776185 3777612 D amidase amiD 3776185..3777612 Mycobacterium bovis BCG str. Pasteur 1173P2 4697827 YP_979526.1 CDS BCG_3447 NC_008769.1 3777720 3778373 D hypothetical protein 3777720..3778373 Mycobacterium bovis BCG str. Pasteur 1173P2 4697301 YP_979527.1 CDS BCG_3448c NC_008769.1 3778465 3779916 R In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, a frameshift due to a 4 bp to 3 bp substitution (caat-aac) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; cyclase complement(3778465..3779916) Mycobacterium bovis BCG str. Pasteur 1173P2 4699095 YP_979528.1 CDS BCG_3449c NC_008769.1 3779921 3780811 R Differs from Rv3378c and Mb3412c by 1aa, A137V; hypothetical protein complement(3779921..3780811) Mycobacterium bovis BCG str. Pasteur 1173P2 4698445 YP_979529.2 CDS dxs2 NC_008769.1 3780820 3782658 R catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase complement(3780820..3782658) Mycobacterium bovis BCG str. Pasteur 1173P2 4699334 YP_979530.1 CDS lytB1 NC_008769.1 3782655 3783644 R lytB-related protein lytB1 complement(3782655..3783644) Mycobacterium bovis BCG str. Pasteur 1173P2 4696508 YP_979531.1 CDS idsB NC_008769.1 3783644 3784696 R Differs from Rv3383c by 1aa, G132V; polyprenyl synthetase idsB complement(3783644..3784696) Mycobacterium bovis BCG str. Pasteur 1173P2 4697180 YP_979532.1 CDS BCG_3453c NC_008769.1 3785450 3785842 R hypothetical protein complement(3785450..3785842) Mycobacterium bovis BCG str. Pasteur 1173P2 4696223 YP_979533.1 CDS BCG_3454c NC_008769.1 3785842 3786150 R hypothetical protein complement(3785842..3786150) Mycobacterium bovis BCG str. Pasteur 1173P2 4698563 YP_979534.1 CDS BCG_3455 NC_008769.1 3786299 3787003 D transposase 3786299..3787003 Mycobacterium bovis BCG str. Pasteur 1173P2 4698867 YP_979535.1 CDS BCG_3456 NC_008769.1 3786993 3787670 D transposase 3786993..3787670 Mycobacterium bovis BCG str. Pasteur 1173P2 4698917 YP_979536.1 CDS PE_PGRS52 NC_008769.1 3787860 3790112 D In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, insertions of 60 bp and 78 bp, and deletions of 75 bp and 9 bp (cggcggcgc-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (750 aa and 749 aa versus 731 aa). Differs from Mb3420 by 1aa insertion, A205; PE-PGRS family protein 3787860..3790112 Mycobacterium bovis BCG str. Pasteur 1173P2 4699142 YP_979537.1 CDS BCG_3458c NC_008769.1 3790183 3791055 R Differs from Mb3421c by 1aa, P172L; dehydrogenase complement(3790183..3791055) Mycobacterium bovis BCG str. Pasteur 1173P2 4695721 YP_979538.1 CDS lpqD NC_008769.1 3791129 3791839 D lipoprotein lpqD 3791129..3791839 Mycobacterium bovis BCG str. Pasteur 1173P2 4696628 YP_979539.1 CDS acrA1 NC_008769.1 3791885 3793837 D short chain dehydrogenase 3791885..3793837 Mycobacterium bovis BCG str. Pasteur 1173P2 4696107 YP_979540.1 CDS cmaA1 NC_008769.1 3793838 3794701 R Differs from Rv3392c by 1aa, S112N; cyclopropane-fatty-acyl-phospholipid synthase 1 cmaA1 complement(3793838..3794701) Mycobacterium bovis BCG str. Pasteur 1173P2 4696511 YP_979541.1 CDS iunH NC_008769.1 3794725 3795651 D nucleoside hydrolase iunH 3794725..3795651 Mycobacterium bovis BCG str. Pasteur 1173P2 4698492 YP_979542.1 CDS BCG_3463c NC_008769.1 3795706 3797289 R hypothetical protein complement(3795706..3797289) Mycobacterium bovis BCG str. Pasteur 1173P2 4697348 YP_979543.1 CDS BCG_3464c NC_008769.1 3797286 3797900 R Differs from Rv3395c by 2aa, V3A, M104V; hypothetical protein complement(3797286..3797900) Mycobacterium bovis BCG str. Pasteur 1173P2 4698491 YP_979544.1 CDS BCG_3465 NC_008769.1 3797983 3798609 D hypothetical protein 3797983..3798609 Mycobacterium bovis BCG str. Pasteur 1173P2 4699220 YP_979545.1 CDS guaA NC_008769.1 3798765 3800342 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(3798765..3800342) Mycobacterium bovis BCG str. Pasteur 1173P2 4698540 YP_979546.1 CDS phyA NC_008769.1 3800354 3801262 R phytoene synthase phyA complement(3800354..3801262) Mycobacterium bovis BCG str. Pasteur 1173P2 4697814 YP_979547.1 CDS idsA1 NC_008769.1 3801291 3802370 R multifunctional geranylgeranyl pyrophosphate synthetase idsA1 complement(3801291..3802370) Mycobacterium bovis BCG str. Pasteur 1173P2 4697038 YP_979548.1 CDS BCG_3469 NC_008769.1 3802393 3803439 D Differs from Rv3399 by 1aa, E330A; hypothetical protein 3802393..3803439 Mycobacterium bovis BCG str. Pasteur 1173P2 4696221 YP_979549.1 CDS BCG_3470 NC_008769.1 3803503 3804291 D hydrolase 3803503..3804291 Mycobacterium bovis BCG str. Pasteur 1173P2 4698786 YP_979550.1 CDS BCG_3471 NC_008769.1 3804306 3806666 D Differs from Mb3434 by 1aa, R658H; hypothetical protein 3804306..3806666 Mycobacterium bovis BCG str. Pasteur 1173P2 4698382 YP_979551.1 CDS BCG_3472c NC_008769.1 3807341 3808393 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transversion (c-g) leads to a shorter product. Differs from Mb3436c by 1aa, R154C; hypothetical protein complement(3807341..3808393) Mycobacterium bovis BCG str. Pasteur 1173P2 4698183 YP_979552.1 CDS BCG_3473c NC_008769.1 3808764 3810365 R hypothetical protein complement(3808764..3810365) Mycobacterium bovis BCG str. Pasteur 1173P2 4698934 YP_979553.1 CDS BCG_3474c NC_008769.1 3810382 3811086 R hypothetical protein complement(3810382..3811086) Mycobacterium bovis BCG str. Pasteur 1173P2 4699012 YP_979554.1 CDS BCG_3475c NC_008769.1 3811204 3811770 R transcriptional regulatory protein complement(3811204..3811770) Mycobacterium bovis BCG str. Pasteur 1173P2 4698583 YP_979555.1 CDS BCG_3476 NC_008769.1 3811832 3812719 D dioxygenase 3811832..3812719 Mycobacterium bovis BCG str. Pasteur 1173P2 4698010 YP_979556.1 CDS BCG_3477 NC_008769.1 3812754 3813053 D hypothetical protein 3812754..3813053 Mycobacterium bovis BCG str. Pasteur 1173P2 4698519 YP_979557.1 CDS BCG_3478 NC_008769.1 3813050 3813460 D Differs from Rv3408 by 1aa, L46S; hypothetical protein 3813050..3813460 Mycobacterium bovis BCG str. Pasteur 1173P2 4698945 YP_979558.1 CDS choD NC_008769.1 3813493 3815229 R cholesterol oxidase precursor choD complement(3813493..3815229) Mycobacterium bovis BCG str. Pasteur 1173P2 4698864 YP_979559.1 CDS guaB3 NC_008769.1 3815285 3816412 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase complement(3815285..3816412) Mycobacterium bovis BCG str. Pasteur 1173P2 4696697 YP_979560.1 CDS guaB2 NC_008769.1 3816432 3818021 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(3816432..3818021) Mycobacterium bovis BCG str. Pasteur 1173P2 4695439 YP_979561.1 CDS BCG_3482 NC_008769.1 3818228 3818638 D hypothetical protein 3818228..3818638 Mycobacterium bovis BCG str. Pasteur 1173P2 4697816 YP_979562.1 CDS BCG_3483c NC_008769.1 3818648 3819547 R hypothetical protein complement(3818648..3819547) Mycobacterium bovis BCG str. Pasteur 1173P2 4699273 YP_979563.1 CDS sigD NC_008769.1 3819540 3820178 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase; RNA polymerase sigma factor SigD complement(3819540..3820178) Mycobacterium bovis BCG str. Pasteur 1173P2 4698371 YP_979564.1 CDS BCG_3485c NC_008769.1 3820196 3821023 R hypothetical protein complement(3820196..3821023) Mycobacterium bovis BCG str. Pasteur 1173P2 4695816 YP_979565.1 CDS whiB3 NC_008769.1 3821394 3821702 D transcriptional regulatory protein whiB-like whib3 3821394..3821702 Mycobacterium bovis BCG str. Pasteur 1173P2 4695415 YP_979566.1 CDS groEL NC_008769.1 3821774 3823393 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth; chaperonin GroEL complement(3821774..3823393) Mycobacterium bovis BCG str. Pasteur 1173P2 4697342 YP_979567.1 CDS groES NC_008769.1 3823488 3823790 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(3823488..3823790) Mycobacterium bovis BCG str. Pasteur 1173P2 4698394 YP_979568.1 CDS gcp NC_008769.1 3824057 3825091 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease complement(3824057..3825091) Mycobacterium bovis BCG str. Pasteur 1173P2 4698396 YP_979569.1 CDS rimI NC_008769.1 3825088 3825564 R ribosomal-protein-alanine acetyltransferase rimI complement(3825088..3825564) Mycobacterium bovis BCG str. Pasteur 1173P2 4696529 YP_979570.1 CDS BCG_3491c NC_008769.1 3825561 3826196 R hypothetical protein complement(3825561..3826196) Mycobacterium bovis BCG str. Pasteur 1173P2 4695904 YP_979571.1 CDS BCG_3492c NC_008769.1 3826193 3826699 R hypothetical protein complement(3826193..3826699) Mycobacterium bovis BCG str. Pasteur 1173P2 4698273 YP_979572.1 CDS alr NC_008769.1 3826696 3827922 R converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase complement(3826696..3827922) Mycobacterium bovis BCG str. Pasteur 1173P2 4698550 YP_979573.1 CDS BCG_3494c NC_008769.1 3828216 3828578 R hypothetical protein complement(3828216..3828578) Mycobacterium bovis BCG str. Pasteur 1173P2 4698623 YP_979574.1 CDS PPE57 NC_008769.1 3828741 3829277 D In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a large deletion of 4926 bp (RD6) leads to the loss of the COOH part of PPE57, and the following CDSs, PPE58, Rv3427c, Rv3428c and the NH2-part of PPE59 compared to Mycobacterium tuberculosis strain H37Rv; PPE family protein 3828741..3829277 Mycobacterium bovis BCG str. Pasteur 1173P2 4699327 YP_979575.1 CDS BCG_3496c NC_008769.1 3829218 3830381 R Differs from Mb3460c by 1aa, R233H; transposase complement(3829218..3830381) Mycobacterium bovis BCG str. Pasteur 1173P2 4698214 YP_979576.1 CDS BCG_3497c NC_008769.1 3830870 3831715 R transposase complement(3830870..3831715) Mycobacterium bovis BCG str. Pasteur 1173P2 4698593 YP_979577.1 CDS gadB NC_008769.1 3831948 3833330 R glutamate decarboxylase gadB complement(3831948..3833330) Mycobacterium bovis BCG str. Pasteur 1173P2 4698524 YP_979578.1 CDS BCG_3499c NC_008769.1 3833368 3834786 R Differs from Mb3463c by 1aa, A436 deleted, and from Rv3433c by 2aa, A436 deleted, A442S; hypothetical protein complement(3833368..3834786) Mycobacterium bovis BCG str. Pasteur 1173P2 4695552 YP_979579.1 CDS BCG_3500c NC_008769.1 3834788 3835501 R Differs from Mb3464c by 1aa, A193T; hypothetical protein complement(3834788..3835501) Mycobacterium bovis BCG str. Pasteur 1173P2 4698755 YP_979580.1 CDS BCG_3501c NC_008769.1 3835512 3836366 R hypothetical protein complement(3835512..3836366) Mycobacterium bovis BCG str. Pasteur 1173P2 4699135 YP_979581.1 CDS glmS NC_008769.1 3836588 3838462 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(3836588..3838462) Mycobacterium bovis BCG str. Pasteur 1173P2 4698443 YP_979582.1 CDS BCG_3503 NC_008769.1 3838484 3838960 D Differs from Rv3437 by 1aa P84L; hypothetical protein 3838484..3838960 Mycobacterium bovis BCG str. Pasteur 1173P2 4696645 YP_979583.1 CDS BCG_3504 NC_008769.1 3838970 3839812 D hypothetical protein 3838970..3839812 Mycobacterium bovis BCG str. Pasteur 1173P2 4698812 YP_979584.1 CDS BCG_3505c NC_008769.1 3839832 3841235 R hypothetical protein complement(3839832..3841235) Mycobacterium bovis BCG str. Pasteur 1173P2 4698036 YP_979585.1 CDS BCG_3506c NC_008769.1 3841238 3841549 R hypothetical protein complement(3841238..3841549) Mycobacterium bovis BCG str. Pasteur 1173P2 4698754 YP_979586.1 CDS glmM NC_008769.1 3841597 3842943 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(3841597..3842943) Mycobacterium bovis BCG str. Pasteur 1173P2 4697009 YP_979587.1 CDS rpsI NC_008769.1 3843068 3843523 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(3843068..3843523) Mycobacterium bovis BCG str. Pasteur 1173P2 4698098 YP_979588.1 CDS rplM NC_008769.1 3843520 3843963 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(3843520..3843963) Mycobacterium bovis BCG str. Pasteur 1173P2 4695756 YP_979589.1 CDS esxT NC_008769.1 3844196 3844498 R hypothetical protein complement(3844196..3844498) Mycobacterium bovis BCG str. Pasteur 1173P2 4695928 YP_979590.1 CDS esxU NC_008769.1 3844519 3844896 R hypothetical protein complement(3844519..3844896) Mycobacterium bovis BCG str. Pasteur 1173P2 4695613 YP_979591.1 CDS BCG_3512c NC_008769.1 3844889 3846103 R hypothetical protein complement(3844889..3846103) Mycobacterium bovis BCG str. Pasteur 1173P2 4696842 YP_979592.1 CDS BCG_3513c NC_008769.1 3846100 3849810 R Differs from Rv3444c by 1 aa, G1082S and Mb3477c by 1 aa G1159S; hypothetical protein complement(3846100..3849810) Mycobacterium bovis BCG str. Pasteur 1173P2 4699031 YP_979593.1 CDS BCG_3514 NC_008769.1 3849924 3851327 D Differs from Mb3478 by 1aa A265D; integral membrane protein 3849924..3851327 Mycobacterium bovis BCG str. Pasteur 1173P2 4698388 YP_979594.1 CDS BCG_3515 NC_008769.1 3851324 3852691 D serine protease 3851324..3852691 Mycobacterium bovis BCG str. Pasteur 1173P2 4699136 YP_979595.1 CDS BCG_3516c NC_008769.1 3852656 3854068 R hypothetical protein complement(3852656..3854068) Mycobacterium bovis BCG str. Pasteur 1173P2 4698895 YP_979596.1 CDS cut3 NC_008769.1 3854189 3854974 D Differs from Rv3451 and Mb3481 by deletion of 1aa, 262R; cutinase precursor cut3 3854189..3854974 Mycobacterium bovis BCG str. Pasteur 1173P2 4698969 YP_979597.1 CDS cut4 NC_008769.1 3855021 3855701 D cutinase precursor cut4 3855021..3855701 Mycobacterium bovis BCG str. Pasteur 1173P2 4695733 YP_979598.1 CDS BCG_3519 NC_008769.1 3855973 3857658 D In Mycobacterium tuberculosis H37Rv, Rv3453 and Rv3454 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (t-*) results in a single product that is more similar to Rv3454. Differs from Mb3483 by 1aa, V328I; hypothetical protein 3855973..3857658 Mycobacterium bovis BCG str. Pasteur 1173P2 4695612 YP_979599.1 CDS truA NC_008769.1 3857620 3858390 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(3857620..3858390) Mycobacterium bovis BCG str. Pasteur 1173P2 4698408 YP_979600.1 CDS rplQ NC_008769.1 3858458 3859000 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(3858458..3859000) Mycobacterium bovis BCG str. Pasteur 1173P2 4695831 YP_979601.1 CDS rpoA NC_008769.1 3859032 3860075 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(3859032..3860075) Mycobacterium bovis BCG str. Pasteur 1173P2 4695892 YP_979602.1 CDS rpsD NC_008769.1 3860226 3860831 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(3860226..3860831) Mycobacterium bovis BCG str. Pasteur 1173P2 4696374 YP_979603.1 CDS rpsK NC_008769.1 3860840 3861259 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(3860840..3861259) Mycobacterium bovis BCG str. Pasteur 1173P2 4697298 YP_979604.1 CDS rpsM NC_008769.1 3861263 3861637 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(3861263..3861637) Mycobacterium bovis BCG str. Pasteur 1173P2 4695758 YP_979605.1 CDS rpmJ NC_008769.1 3861853 3861966 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 complement(3861853..3861966) Mycobacterium bovis BCG str. Pasteur 1173P2 4698850 YP_979606.1 CDS infA NC_008769.1 3861999 3862220 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(3861999..3862220) Mycobacterium bovis BCG str. Pasteur 1173P2 4695801 YP_979607.1 CDS BCG_3528 NC_008769.1 3862474 3863331 D hypothetical protein 3862474..3863331 Mycobacterium bovis BCG str. Pasteur 1173P2 4698977 YP_979608.1 CDS rmlB1 NC_008769.1 3863404 3864399 D dTDP-glucose 4,6-dehydratase rmlB1 3863404..3864399 Mycobacterium bovis BCG str. Pasteur 1173P2 4698485 YP_979609.1 CDS rmlC NC_008769.1 3864401 3865009 D dTDP-4-dehydrorhamnose 3,5-epimerase rmlC 3864401..3865009 Mycobacterium bovis BCG str. Pasteur 1173P2 4695584 YP_979610.1 CDS BCG_3531 NC_008769.1 3865092 3865760 D Differs from Rv3466 by 4aa, T56A, T63A, L91R, I131V; hypothetical protein 3865092..3865760 Mycobacterium bovis BCG str. Pasteur 1173P2 4695586 YP_979611.1 CDS BCG_3532 NC_008769.1 3865531 3866484 D Differs from Rv3467 by 6aa, E134K, G245A, D262G, R275H, K276N, E315K; hypothetical protein 3865531..3866484 Mycobacterium bovis BCG str. Pasteur 1173P2 4698050 YP_979612.1 CDS rmlB2 NC_008769.1 3866542 3867636 R Differs from Rv3468c by 1aa, V62I; dTDP-glucose 4,6-dehydratase rmlB2 complement(3866542..3867636) Mycobacterium bovis BCG str. Pasteur 1173P2 4698265 YP_979613.1 CDS mhpE NC_008769.1 3867640 3868650 R catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase complement(3867640..3868650) Mycobacterium bovis BCG str. Pasteur 1173P2 4695585 YP_979614.1 CDS ilvB2 NC_008769.1 3868711 3870369 R Differs from Mb3499c by 1aa, G421E; acetolactate synthase large subunit IlvB complement(3868711..3870369) Mycobacterium bovis BCG str. Pasteur 1173P2 4699001 YP_979615.1 CDS BCG_3536c NC_008769.1 3870375 3870908 R Differs from Mb3500c by 1aa, C155W; hypothetical protein complement(3870375..3870908) Mycobacterium bovis BCG str. Pasteur 1173P2 4699339 YP_979616.1 CDS BCG_3537 NC_008769.1 3870929 3871435 D hypothetical protein 3870929..3871435 Mycobacterium bovis BCG str. Pasteur 1173P2 4698267 YP_979617.1 CDS bpoA NC_008769.1 3871515 3872300 R peroxidase bpoA complement(3871515..3872300) Mycobacterium bovis BCG str. Pasteur 1173P2 4699324 YP_979618.1 CDS kgtP NC_008769.1 3872580 3873929 R Differs from Rv3476c by 2aa, F81L, V144A; dicarboxylic acid transport integral membrane protein kgtP complement(3872580..3873929) Mycobacterium bovis BCG str. Pasteur 1173P2 4695553 YP_979619.1 CDS PE31 NC_008769.1 3874302 3874598 D Differs from Rv3477 by 1aa, A26V; PE family protein 3874302..3874598 Mycobacterium bovis BCG str. Pasteur 1173P2 4696456 YP_979620.1 CDS PPE60 NC_008769.1 3874635 3875816 D PE family protein 3874635..3875816 Mycobacterium bovis BCG str. Pasteur 1173P2 4698938 YP_979621.1 CDS BCG_3542 NC_008769.1 3876029 3877330 D In Mycobacterium tuberculosis strain H37Rv, Rv3479 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a 713 bp deletion(RD18) splits Rv3479 into 2 parts, Mb3507 and Mb3508. Differs from Rv3479 by 1aa, R174L; hypothetical protein 3876029..3877330 Mycobacterium bovis BCG str. Pasteur 1173P2 4698216 YP_979622.1 CDS BCG_3543 NC_008769.1 3877335 3878381 D In Mycobacterium tuberculosis strain H37Rv, Rv3479 exists as a single gene. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a 713 bp deletion (RD18) splits Rv3479 into 2 parts, Mb3507 and Mb3508. Differs from Rv3479 by 1aa, N344T; hypothetical protein 3877335..3878381 Mycobacterium bovis BCG str. Pasteur 1173P2 4698775 YP_979623.1 CDS BCG_3544c NC_008769.1 3878405 3879898 R In Mycobacterium tuberculosis strain H37Rv, Rv3480c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (gt-*) splits Rv3480c into 2 parts, Mb3509c and Mb3510c. Differs from Rv3480c and Mb3510c by 1aa, N205D; hypothetical protein complement(3878405..3879898) Mycobacterium bovis BCG str. Pasteur 1173P2 4698259 YP_979624.1 CDS BCG_3545c NC_008769.1 3879989 3880678 R integral membrane protein complement(3879989..3880678) Mycobacterium bovis BCG str. Pasteur 1173P2 4698873 YP_979625.1 CDS BCG_3546c NC_008769.1 3880113 3881603 R BCG_3546c; In Mycobacterium bovis BCG Pasteur, a single base insertion (C) at position equivalent to Mycobacterium tuberculosis H37Rv position 3901442-3901443 leads to frameshift and longer product of 496 aa compared to Rv3482c, len: 260 aa; hypothetical protein complement(3880113..3881603) Mycobacterium bovis BCG str. Pasteur 1173P2 4699160 YP_979626.1 CDS BCG_3547c NC_008769.1 3881647 3882309 R hypothetical protein complement(3881647..3882309) Mycobacterium bovis BCG str. Pasteur 1173P2 4699022 YP_979627.1 CDS cpsA NC_008769.1 3882575 3884113 D protein cpsA 3882575..3884113 Mycobacterium bovis BCG str. Pasteur 1173P2 4698729 YP_979628.1 CDS BCG_3549c NC_008769.1 3884119 3885063 R short chain dehydrogenase complement(3884119..3885063) Mycobacterium bovis BCG str. Pasteur 1173P2 4697923 YP_979629.1 CDS BCG_3550 NC_008769.1 3885269 3885718 D hypothetical protein 3885269..3885718 Mycobacterium bovis BCG str. Pasteur 1173P2 4698513 YP_979630.1 CDS lipF NC_008769.1 3885671 3886504 R esterase/lipase lipF complement(3885671..3886504) Mycobacterium bovis BCG str. Pasteur 1173P2 4698963 YP_979631.1 CDS BCG_3552 NC_008769.1 3887164 3887487 D Differs from Rv3488 by 1aa, R98G; hypothetical protein 3887164..3887487 Mycobacterium bovis BCG str. Pasteur 1173P2 4698085 YP_979632.1 CDS BCG_3553 NC_008769.1 3887569 3887733 D hypothetical protein 3887569..3887733 Mycobacterium bovis BCG str. Pasteur 1173P2 4699245 YP_979633.1 CDS otsA NC_008769.1 3887733 3889235 D Differs from Rv3490 by 1aa, L334V; alpha, alpha-trehalose-phosphate synthase OtsA 3887733..3889235 Mycobacterium bovis BCG str. Pasteur 1173P2 4698947 YP_979634.1 CDS BCG_3555 NC_008769.1 3889387 3889965 D hypothetical protein 3889387..3889965 Mycobacterium bovis BCG str. Pasteur 1173P2 4698922 YP_979635.1 CDS BCG_3556c NC_008769.1 3889962 3890444 R Mce-associated protein complement(3889962..3890444) Mycobacterium bovis BCG str. Pasteur 1173P2 4699090 YP_979636.1 CDS BCG_3557c NC_008769.1 3890444 3891172 R Mce-associated protein complement(3890444..3891172) Mycobacterium bovis BCG str. Pasteur 1173P2 4699292 YP_979637.1 CDS mce4F NC_008769.1 3891172 3892866 R Differs from Rv3494c by 1aa, G245D; Mce-family protein mce4F complement(3891172..3892866) Mycobacterium bovis BCG str. Pasteur 1173P2 4697965 YP_979638.1 CDS lprN NC_008769.1 3892877 3894031 R mce family lipoprotein LprN complement(3892877..3894031) Mycobacterium bovis BCG str. Pasteur 1173P2 4697638 YP_979639.1 CDS mce4D NC_008769.1 3894028 3895383 R Mce-family protein mce4D complement(3894028..3895383) Mycobacterium bovis BCG str. Pasteur 1173P2 4698590 YP_979640.1 CDS mce4C NC_008769.1 3895380 3896453 R Differs from Mb3527c and Rv3497c by 1aa, P46T; Mce-family protein mce4C complement(3895380..3896453) Mycobacterium bovis BCG str. Pasteur 1173P2 4697637 YP_979641.1 CDS mce4B NC_008769.1 3896443 3897495 R Mce-family protein mce4B complement(3896443..3897495) Mycobacterium bovis BCG str. Pasteur 1173P2 4697636 YP_979642.1 CDS mce4A NC_008769.1 3897495 3898697 R Mce-family protein mce4A complement(3897495..3898697) Mycobacterium bovis BCG str. Pasteur 1173P2 4697635 YP_979643.1 CDS yrbE4B NC_008769.1 3898717 3899559 R integral membrane protein YrbE4b complement(3898717..3899559) Mycobacterium bovis BCG str. Pasteur 1173P2 4695888 YP_979644.1 CDS yrbE4A NC_008769.1 3899594 3900358 R integral membrane protein YrbE4a complement(3899594..3900358) Mycobacterium bovis BCG str. Pasteur 1173P2 4695515 YP_979645.1 CDS fabG NC_008769.1 3900584 3901537 R Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(3900584..3901537) Mycobacterium bovis BCG str. Pasteur 1173P2 4695514 YP_979646.1 CDS fdxD NC_008769.1 3901562 3901753 R ferredoxin fdxD complement(3901562..3901753) Mycobacterium bovis BCG str. Pasteur 1173P2 4699015 YP_979647.1 CDS fadE26 NC_008769.1 3901968 3903170 D acyl-CoA dehydrogenase fadE26 3901968..3903170 Mycobacterium bovis BCG str. Pasteur 1173P2 4695362 YP_979648.1 CDS fadE27 NC_008769.1 3903195 3904316 D Differs from Rv3505 by 1aa V218A; acyl-CoA dehydrogenase fadE27 3903195..3904316 Mycobacterium bovis BCG str. Pasteur 1173P2 4697414 YP_979649.1 CDS fadD17 NC_008769.1 3904387 3905895 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3904387..3905895 Mycobacterium bovis BCG str. Pasteur 1173P2 4697415 YP_979650.1 CDS PE_PGRS53 NC_008769.1 3906066 3910184 D In Mycobacterium bovis , insertions of 18 bp, 72 bp and 9 bp (*-cggcggcac), and deletions of 90 bp, 54 bp and 18 bp, and Mycobacterium bovis BCG Pasteur, insertions of 18 bp, 81 bp and 9 bp (*-cggcggcac), and deletions of 90 bp, 27 bp and 18 bp, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1360 aa and 1372 aa versus 1381 aa). Differs from Mb3537 by 2 insertions of 9aa and 3aa and by 1aa, N599D. Differs from Rv3507 by several insertions, deletions and by 2aa, N599D, G742D; PE-PGRS family protein 3906066..3910184 Mycobacterium bovis BCG str. Pasteur 1173P2 4698964 YP_979651.1 CDS PE_PGRS54 NC_008769.1 3910475 3916759 D In Mycobacterium bovis BCG Pasteur several insertions lead to a longer product compared to its homolog in Mycobacterium bovis (2094 aa versus 1460 aa); PE-PGRS family protein 3910475..3916759 Mycobacterium bovis BCG str. Pasteur 1173P2 4697028 YP_979652.1 CDS ilvX NC_008769.1 3916926 3918473 R thiamine-pyrophosphate requiring enzyme; hypothetical protein complement(3916926..3918473) Mycobacterium bovis BCG str. Pasteur 1173P2 4697029 YP_979653.1 CDS BCG_3574c NC_008769.1 3918470 3919306 R hypothetical protein complement(3918470..3919306) Mycobacterium bovis BCG str. Pasteur 1173P2 4698975 YP_979654.1 CDS PE_PGRS55 NC_008769.1 3919666 3925098 D In Mycobacterium tuberculosis H37Rv, PE_PGRS55 and PE_PGRS56 exist as 2 genes. In Mycobacterium bovis, a 344 bp insertion results in a single product which is more similar to PE_PGRS55. In Mycobacterium bovis BCG Pasteur two deletions of 138bp and 246 bp lead to a shorter product compared to its homolog Mycobacterium bovis (1810 aa versus 1938 aa). Also differs from Mb3541 by 3aa, D628A, D743A and D857A; PE-PGRS family protein 3919666..3925098 Mycobacterium bovis BCG str. Pasteur 1173P2 4698242 YP_979655.1 CDS fadD18 NC_008769.1 3925227 3925883 R fatty-acid-CoA ligase fadD18 complement(3925227..3925883) Mycobacterium bovis BCG str. Pasteur 1173P2 4697030 YP_979656.1 CDS PE_PGRS57 NC_008769.1 3925929 3929156 D In Mycobacterium bovis BCG Pasteur a deletion of 111 bp and an insertion of 360 bp lead to a longer product compared to its homolog Mycobacterium bovis. Also differs from Mb3543 by 2aa, S80L and T93A; PE-PGRS family protein 3925929..3929156 Mycobacterium bovis BCG str. Pasteur 1173P2 4698983 YP_979657.1 CDS fadD19 NC_008769.1 3929717 3931363 R activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence; acyl-CoA synthetase complement(3929717..3931363) Mycobacterium bovis BCG str. Pasteur 1173P2 4697031 YP_979658.1 CDS echA19 NC_008769.1 3931437 3932228 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 3931437..3932228 Mycobacterium bovis BCG str. Pasteur 1173P2 4698641 YP_979659.1 CDS BCG_3580 NC_008769.1 3932324 3933163 D hypothetical protein 3932324..3933163 Mycobacterium bovis BCG str. Pasteur 1173P2 4696809 YP_979660.1 CDS cyp142b NC_008769.1 3933218 3933799 R In Mycobacterium tuberculosis strain H37Rv, cyp142 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (c-*) splits cyp142 into 2 parts, cyp142a and cyp142b; cytochrome P450 monooxygenase 142 cyp142b complement(3933218..3933799) Mycobacterium bovis BCG str. Pasteur 1173P2 4698671 YP_979661.1 CDS cyp142a NC_008769.1 3933796 3934413 R In Mycobacterium tuberculosis strain H37Rv, cyp142 exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base deletion (c-*) splits cyp142 into 2 parts, cyp142a and cyp142b; cytochrome P450 monooxygenase 142 cyp142a complement(3933796..3934413) Mycobacterium bovis BCG str. Pasteur 1173P2 4695561 YP_979662.1 CDS BCG_3583 NC_008769.1 3934442 3935152 D hypothetical protein 3934442..3935152 Mycobacterium bovis BCG str. Pasteur 1173P2 4695545 YP_979663.1 CDS BCG_3584c NC_008769.1 3935217 3936260 R coenzyme F420-dependent oxidoreductase complement(3935217..3936260) Mycobacterium bovis BCG str. Pasteur 1173P2 4698198 YP_979664.1 CDS BCG_3585 NC_008769.1 3936413 3937324 D Differs from Rv3521 by 1aa D295N; hypothetical protein 3936413..3937324 Mycobacterium bovis BCG str. Pasteur 1173P2 4698413 YP_979665.1 CDS BCG_3586 NC_008769.1 3937340 3938404 D Differs from Rv3522 by 1aa I324T; lipid-transfer protein 3937340..3938404 Mycobacterium bovis BCG str. Pasteur 1173P2 4698503 YP_979666.1 CDS BCG_3587 NC_008769.1 3938421 3939605 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 3938421..3939605 Mycobacterium bovis BCG str. Pasteur 1173P2 4698854 YP_979667.1 CDS BCG_3588 NC_008769.1 3939647 3940678 D hypothetical protein 3939647..3940678 Mycobacterium bovis BCG str. Pasteur 1173P2 4698842 YP_979668.1 CDS BCG_3589c NC_008769.1 3940692 3941216 R siderophore-binding protein complement(3940692..3941216) Mycobacterium bovis BCG str. Pasteur 1173P2 4699264 YP_979669.1 CDS BCG_3590 NC_008769.1 3941331 3942491 D oxidoreductase 3941331..3942491 Mycobacterium bovis BCG str. Pasteur 1173P2 4698325 YP_979670.1 CDS BCG_3591 NC_008769.1 3942497 3942946 D hypothetical protein 3942497..3942946 Mycobacterium bovis BCG str. Pasteur 1173P2 4698329 YP_979671.1 CDS BCG_3592c NC_008769.1 3943371 3944084 R hypothetical protein complement(3943371..3944084) Mycobacterium bovis BCG str. Pasteur 1173P2 4699014 YP_979672.1 CDS BCG_3593c NC_008769.1 3944776 3945930 R hypothetical protein complement(3944776..3945930) Mycobacterium bovis BCG str. Pasteur 1173P2 4698891 YP_979673.1 CDS BCG_3594c NC_008769.1 3945930 3946712 R short chain dehydrogenase complement(3945930..3946712) Mycobacterium bovis BCG str. Pasteur 1173P2 4699099 YP_979674.1 CDS BCG_3595c NC_008769.1 3946709 3947836 R hypothetical protein complement(3946709..3947836) Mycobacterium bovis BCG str. Pasteur 1173P2 4698240 YP_979675.1 CDS PPE61 NC_008769.1 3948235 3949455 D PPE family protein 3948235..3949455 Mycobacterium bovis BCG str. Pasteur 1173P2 4699097 YP_979676.1 CDS PPE62 NC_008769.1 3949597 3951345 R PPE family protein complement(3949597..3951345) Mycobacterium bovis BCG str. Pasteur 1173P2 4698217 YP_979677.1 CDS BCG_3598c NC_008769.1 3951444 3952484 R catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase complement(3951444..3952484) Mycobacterium bovis BCG str. Pasteur 1173P2 4697696 YP_979678.1 CDS BCG_3599c NC_008769.1 3952481 3953392 R catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase complement(3952481..3953392) Mycobacterium bovis BCG str. Pasteur 1173P2 4699101 YP_979679.1 CDS BCG_3600c NC_008769.1 3953403 3954188 R hydratase complement(3953403..3954188) Mycobacterium bovis BCG str. Pasteur 1173P2 4698760 YP_979680.1 CDS BCG_3601 NC_008769.1 3954261 3955952 D initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione; 3-ketosteroid-delta-1-dehydrogenase 3954261..3955952 Mycobacterium bovis BCG str. Pasteur 1173P2 4698453 YP_979681.1 CDS BCG_3602 NC_008769.1 3955954 3956814 D dehydrogenase 3955954..3956814 Mycobacterium bovis BCG str. Pasteur 1173P2 4698846 YP_979682.1 CDS PPE63 NC_008769.1 3956951 3958390 D PPE family protein 3956951..3958390 Mycobacterium bovis BCG str. Pasteur 1173P2 4698778 YP_979683.1 CDS ltp2 NC_008769.1 3958391 3959551 R lipid-transfer protein complement(3958391..3959551) Mycobacterium bovis BCG str. Pasteur 1173P2 4697697 YP_979684.1 CDS BCG_3605c NC_008769.1 3959551 3959940 R hypothetical protein complement(3959551..3959940) Mycobacterium bovis BCG str. Pasteur 1173P2 4697176 YP_979685.1 CDS BCG_3606c NC_008769.1 3959937 3960872 R hypothetical protein complement(3959937..3960872) Mycobacterium bovis BCG str. Pasteur 1173P2 4698171 YP_979686.1 CDS fadE29 NC_008769.1 3960869 3962032 R acyl-CoA dehydrogenase fadE29 complement(3960869..3962032) Mycobacterium bovis BCG str. Pasteur 1173P2 4698558 YP_979687.1 CDS fadE28 NC_008769.1 3962017 3963036 R acyl-CoA dehydrogenase fadE28 complement(3962017..3963036) Mycobacterium bovis BCG str. Pasteur 1173P2 4697578 YP_979688.1 CDS cyp125 NC_008769.1 3963036 3964337 R cytochrome P450 125 cyp125 complement(3963036..3964337) Mycobacterium bovis BCG str. Pasteur 1173P2 4697577 YP_979689.1 CDS fadA5 NC_008769.1 3964449 3965624 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 3964449..3965624 Mycobacterium bovis BCG str. Pasteur 1173P2 4696436 YP_979690.1 CDS BCG_3611 NC_008769.1 3965736 3966191 D hypothetical protein 3965736..3966191 Mycobacterium bovis BCG str. Pasteur 1173P2 4699134 YP_979691.1 CDS BCG_3612c NC_008769.1 3966274 3967188 R Differs from Rv3548c by 1aa V218M; short chain dehydrogenase complement(3966274..3967188) Mycobacterium bovis BCG str. Pasteur 1173P2 4699314 YP_979692.1 CDS BCG_3613c NC_008769.1 3967211 3967990 R short chain dehydrogenase complement(3967211..3967990) Mycobacterium bovis BCG str. Pasteur 1173P2 4699221 YP_979693.1 CDS echA20 NC_008769.1 3968045 3968788 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 3968045..3968788 Mycobacterium bovis BCG str. Pasteur 1173P2 4698274 YP_979694.1 CDS BCG_3615 NC_008769.1 3968788 3969666 D Differs from Rv3551 by 1aa, S7A; CoA-transferase subunit alpha 3968788..3969666 Mycobacterium bovis BCG str. Pasteur 1173P2 4697920 YP_979695.1 CDS BCG_3616 NC_008769.1 3969663 3970415 D CoA-transferase subunit beta 3969663..3970415 Mycobacterium bovis BCG str. Pasteur 1173P2 4699075 YP_979696.1 CDS BCG_3617 NC_008769.1 3970513 3971580 D oxidoreductase 3970513..3971580 Mycobacterium bovis BCG str. Pasteur 1173P2 4698257 YP_979697.1 CDS fdxB NC_008769.1 3971577 3973634 D electron transfer protein fdxB 3971577..3973634 Mycobacterium bovis BCG str. Pasteur 1173P2 4699085 YP_979698.1 CDS BCG_3619c NC_008769.1 3973722 3974591 R Differs from Rv3555c by 1aa R268W; hypothetical protein complement(3973722..3974591) Mycobacterium bovis BCG str. Pasteur 1173P2 4695360 YP_979699.1 CDS fadA6 NC_008769.1 3974696 3975856 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(3974696..3975856) Mycobacterium bovis BCG str. Pasteur 1173P2 4696146 YP_979700.1 CDS BCG_3621c NC_008769.1 3975921 3976523 R TetR family transcriptional regulator complement(3975921..3976523) Mycobacterium bovis BCG str. Pasteur 1173P2 4696708 YP_979701.1 CDS PPE64 NC_008769.1 3976872 3978530 D PPE family protein 3976872..3978530 Mycobacterium bovis BCG str. Pasteur 1173P2 4698861 YP_979702.1 CDS BCG_3623c NC_008769.1 3978539 3979327 R Differs from Rv3559c by 1aa V222A; short chain dehydrogenase complement(3978539..3979327) Mycobacterium bovis BCG str. Pasteur 1173P2 4697698 YP_979703.1 CDS fadE30 NC_008769.1 3979324 3980481 R acyl-CoA dehydrogenase fadE30 complement(3979324..3980481) Mycobacterium bovis BCG str. Pasteur 1173P2 4698011 YP_979704.1 CDS fadD3 NC_008769.1 3980529 3982052 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 3980529..3982052 Mycobacterium bovis BCG str. Pasteur 1173P2 4697580 YP_979705.1 CDS fadE31 NC_008769.1 3982053 3983186 D acyl-CoA dehydrogenase fadE31 3982053..3983186 Mycobacterium bovis BCG str. Pasteur 1173P2 4699011 YP_979706.1 CDS fadE32 NC_008769.1 3983183 3984142 D Differs from Rv3563 by 2aa R105Q and S275W; acyl-CoA dehydrogenase fadE32 3983183..3984142 Mycobacterium bovis BCG str. Pasteur 1173P2 4697581 YP_979707.1 CDS fadE33 NC_008769.1 3984139 3985095 D acyl-CoA dehydrogenase fadE33 3984139..3985095 Mycobacterium bovis BCG str. Pasteur 1173P2 4695631 YP_979708.1 CDS aspB NC_008769.1 3985092 3986258 D catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 3985092..3986258 Mycobacterium bovis BCG str. Pasteur 1173P2 4695632 YP_979709.1 CDS nat NC_008769.1 3986223 3987074 R arylamine n-acetyltransferase nat complement(3986223..3987074) Mycobacterium bovis BCG str. Pasteur 1173P2 4695836 YP_979710.1 CDS BCG_3631c NC_008769.1 3987059 3987325 R hypothetical protein complement(3987059..3987325) Mycobacterium bovis BCG str. Pasteur 1173P2 4696136 YP_979711.1 CDS BCG_3632c NC_008769.1 3987611 3988174 R Differs from Rv3567c by 1aa T179I; oxidoreductase complement(3987611..3988174) Mycobacterium bovis BCG str. Pasteur 1173P2 4699092 YP_979712.1 CDS bphC NC_008769.1 3988189 3989091 R Differs from Mb3599c by 1aa Q177R; biphenyl-2,3-diol 1,2-dioxygenase bphC complement(3988189..3989091) Mycobacterium bovis BCG str. Pasteur 1173P2 4699277 YP_979713.1 CDS bphD NC_008769.1 3989088 3989963 R 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase complement(3989088..3989963) Mycobacterium bovis BCG str. Pasteur 1173P2 4697051 YP_979714.1 CDS BCG_3635c NC_008769.1 3989978 3991162 R Differs from Rv3570c by 1aa D18N; oxidoreductase complement(3989978..3991162) Mycobacterium bovis BCG str. Pasteur 1173P2 4697113 YP_979715.1 CDS hmp NC_008769.1 3991309 3992385 D hemoglobine-related protein hmp 3991309..3992385 Mycobacterium bovis BCG str. Pasteur 1173P2 4698586 YP_979716.1 CDS BCG_3637 NC_008769.1 3992403 3992933 D hypothetical protein 3992403..3992933 Mycobacterium bovis BCG str. Pasteur 1173P2 4696100 YP_979717.1 CDS fadE34 NC_008769.1 3992969 3995104 R acyl-CoA dehydrogenase fadE34 complement(3992969..3995104) Mycobacterium bovis BCG str. Pasteur 1173P2 4698233 YP_979718.1 CDS BCG_3639 NC_008769.1 3995376 3995975 D TetR family transcriptional regulator 3995376..3995975 Mycobacterium bovis BCG str. Pasteur 1173P2 4695633 YP_979719.1 CDS BCG_3640c NC_008769.1 3995981 3997060 R LacI family transcriptional regulator complement(3995981..3997060) Mycobacterium bovis BCG str. Pasteur 1173P2 4699230 YP_979720.1 CDS lppH NC_008769.1 3997250 3997963 D Differs from Rv3576 by 1aa N118D; lipoprotein lppH 3997250..3997963 Mycobacterium bovis BCG str. Pasteur 1173P2 4698792 YP_979721.1 CDS BCG_3642 NC_008769.1 3998154 3999020 D hypothetical protein 3998154..3999020 Mycobacterium bovis BCG str. Pasteur 1173P2 4696497 YP_979722.1 CDS arsB2 NC_008769.1 3999034 4000275 D Differs from Rv3578 by 1aa S319A; arsenical pump integral membrane protein arsB2 3999034..4000275 Mycobacterium bovis BCG str. Pasteur 1173P2 4698279 YP_979723.1 CDS BCG_3644c NC_008769.1 4000317 4001285 R Differs from Rv3579c by 1aa, A302E. Mb3610c is longer due to frameshift and differs by 1aa V178M; tRNA/rRNA methyltransferase complement(4000317..4001285) Mycobacterium bovis BCG str. Pasteur 1173P2 4695813 YP_979724.1 CDS cysS NC_008769.1 4001286 4002695 R catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase complement(4001286..4002695) Mycobacterium bovis BCG str. Pasteur 1173P2 4699126 YP_979725.1 CDS ispF NC_008769.1 4002760 4003239 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(4002760..4003239) Mycobacterium bovis BCG str. Pasteur 1173P2 4696145 YP_979726.1 CDS ispD NC_008769.1 4003236 4003931 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(4003236..4003931) Mycobacterium bovis BCG str. Pasteur 1173P2 4697347 YP_979727.1 CDS BCG_3648c NC_008769.1 4003948 4004436 R transcription factor complement(4003948..4004436) Mycobacterium bovis BCG str. Pasteur 1173P2 4697435 YP_979728.1 CDS lpqE NC_008769.1 4004721 4005269 D lipoprotein lpqE 4004721..4005269 Mycobacterium bovis BCG str. Pasteur 1173P2 4699218 YP_979729.1 CDS radA NC_008769.1 4005335 4006777 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 4005335..4006777 Mycobacterium bovis BCG str. Pasteur 1173P2 4696108 YP_979730.1 CDS BCG_3651 NC_008769.1 4006782 4007858 D non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair; DNA integrity scanning protein DisA 4006782..4007858 Mycobacterium bovis BCG str. Pasteur 1173P2 4695436 YP_979731.1 CDS BCG_3652c NC_008769.1 4007859 4008650 R Shorter than Rv3587c and Mb3618c by 1aa, P at 240; hypothetical protein complement(4007859..4008650) Mycobacterium bovis BCG str. Pasteur 1173P2 4698218 YP_979732.1 CDS canB NC_008769.1 4008759 4009382 R Differs from Mb3619c by 1aa I79T; carbonic anhydrase complement(4008759..4009382) Mycobacterium bovis BCG str. Pasteur 1173P2 4698358 YP_979733.1 CDS mutY NC_008769.1 4009381 4010295 D adenine glycosylase 4009381..4010295 Mycobacterium bovis BCG str. Pasteur 1173P2 4695777 YP_979734.1 CDS PE_PGRS58 NC_008769.1 4010292 4012046 R PE-PGRS family protein complement(4010292..4012046) Mycobacterium bovis BCG str. Pasteur 1173P2 4695712 YP_979735.1 CDS BCG_3656c NC_008769.1 4012157 4012930 R hydrolase complement(4012157..4012930) Mycobacterium bovis BCG str. Pasteur 1173P2 4697032 YP_979736.1 CDS TB11.2 NC_008769.1 4012945 4013262 D hypothetical protein 4012945..4013262 Mycobacterium bovis BCG str. Pasteur 1173P2 4698261 YP_979737.1 CDS lpqF NC_008769.1 4013240 4014598 D Differs from Rv3593 by 2 aa, V159A, S186N; lipoprotein lpqF 4013240..4014598 Mycobacterium bovis BCG str. Pasteur 1173P2 4697793 YP_979738.1 CDS BCG_3659 NC_008769.1 4014745 4015572 D hypothetical protein 4014745..4015572 Mycobacterium bovis BCG str. Pasteur 1173P2 4696109 YP_979739.1 CDS PE_PGRS59 NC_008769.1 4015486 4016964 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (a-*) and a 27 bp insertion (*-gcgcgccggggccaccgtttccgccgg), lead to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (492 aa versus 439 aa); PE-PGRS family protein complement(4015486..4016964) Mycobacterium bovis BCG str. Pasteur 1173P2 4698949 YP_979740.1 CDS clpC NC_008769.1 4017072 4019618 R ATP-dependent Clp protease ATP-binding subunit clpC complement(4017072..4019618) Mycobacterium bovis BCG str. Pasteur 1173P2 4699251 YP_979741.1 CDS lsr2 NC_008769.1 4019895 4020233 R lsr2 protein precursor complement(4019895..4020233) Mycobacterium bovis BCG str. Pasteur 1173P2 4698474 YP_979742.1 CDS lysS NC_008769.1 4020337 4021854 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(4020337..4021854) Mycobacterium bovis BCG str. Pasteur 1173P2 4697260 YP_979743.1 CDS BCG_3664c NC_008769.1 4021955 4022773 R type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase complement(4021955..4022773) Mycobacterium bovis BCG str. Pasteur 1173P2 4697178 YP_979744.1 CDS panD NC_008769.1 4022776 4023195 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(4022776..4023195) Mycobacterium bovis BCG str. Pasteur 1173P2 4699169 YP_979745.1 CDS panC NC_008769.1 4023195 4024124 R catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase complement(4023195..4024124) Mycobacterium bovis BCG str. Pasteur 1173P2 4698053 YP_979746.1 CDS BCG_3667c NC_008769.1 4024121 4025032 R hypothetical protein complement(4024121..4025032) Mycobacterium bovis BCG str. Pasteur 1173P2 4695408 YP_979747.1 CDS BCG_3668c NC_008769.1 4025217 4026410 R Differs from Rv3604c by G153V; transmembrane protein rich in alanine and arginine and proline complement(4025217..4026410) Mycobacterium bovis BCG str. Pasteur 1173P2 4698768 YP_979748.1 CDS BCG_3669c NC_008769.1 4026619 4027095 R hypothetical protein complement(4026619..4027095) Mycobacterium bovis BCG str. Pasteur 1173P2 4699077 YP_979749.1 CDS folK NC_008769.1 4027095 4027661 R 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase complement(4027095..4027661) Mycobacterium bovis BCG str. Pasteur 1173P2 4698844 YP_979750.1 CDS folB NC_008769.1 4027658 4028059 R dihydroneopterin aldolase folB complement(4027658..4028059) Mycobacterium bovis BCG str. Pasteur 1173P2 4695627 YP_979751.1 CDS folP1 NC_008769.1 4028052 4028894 R dihydropteroate synthase complement(4028052..4028894) Mycobacterium bovis BCG str. Pasteur 1173P2 4697986 YP_979752.1 CDS folE NC_008769.1 4028891 4029499 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(4028891..4029499) Mycobacterium bovis BCG str. Pasteur 1173P2 4695628 YP_979753.1 CDS ftsH NC_008769.1 4029515 4031797 R membrane-bound protease ftsH complement(4029515..4031797) Mycobacterium bovis BCG str. Pasteur 1173P2 4695626 YP_979754.1 CDS BCG_3675 NC_008769.1 4031864 4032517 D Identical to Rv3611. In Mycobacterium bovis, a 111 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis (180 aa versus 217 aa); hypothetical protein 4031864..4032517 Mycobacterium bovis BCG str. Pasteur 1173P2 4695822 YP_979755.1 CDS BCG_3676c NC_008769.1 4032432 4032761 R hypothetical protein complement(4032432..4032761) Mycobacterium bovis BCG str. Pasteur 1173P2 4698520 YP_979756.1 CDS BCG_3677c NC_008769.1 4032795 4032956 R hypothetical protein complement(4032795..4032956) Mycobacterium bovis BCG str. Pasteur 1173P2 4698584 YP_979757.1 CDS BCG_3678c NC_008769.1 4033056 4033610 R hypothetical protein complement(4033056..4033610) Mycobacterium bovis BCG str. Pasteur 1173P2 4698944 YP_979758.1 CDS BCG_3679c NC_008769.1 4033726 4034037 R hypothetical protein complement(4033726..4034037) Mycobacterium bovis BCG str. Pasteur 1173P2 4699279 YP_979759.1 CDS BCG_3680c NC_008769.1 4034111 4035289 R Differs from Rv3616c by 2aa, V4A, I192T and Mb3646c by 2aa, V4A, V153A; hypothetical protein complement(4034111..4035289) Mycobacterium bovis BCG str. Pasteur 1173P2 4699212 YP_979760.1 CDS lpqG NC_008769.1 4035755 4036270 D In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a large 5894 bp deletion (RD8) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (171 aa versus 240 aa); lipoprotein lpqG 4035755..4036270 Mycobacterium bovis BCG str. Pasteur 1173P2 4698264 YP_979761.1 CDS hpt NC_008769.1 4036275 4036925 R Differs by 2 aa from Rv3624c et Mb3648c A111T, N122D; hypoxanthine-guanine phosphoribosyltransferase hpt complement(4036275..4036925) Mycobacterium bovis BCG str. Pasteur 1173P2 4698154 YP_979762.1 CDS mesJ NC_008769.1 4036922 4037893 R cell cycle protein mesJ complement(4036922..4037893) Mycobacterium bovis BCG str. Pasteur 1173P2 4696102 YP_979763.1 CDS BCG_3684c NC_008769.1 4037872 4038924 R hypothetical protein complement(4037872..4038924) Mycobacterium bovis BCG str. Pasteur 1173P2 4696115 YP_979764.1 CDS BCG_3685c NC_008769.1 4038921 4040306 R Differs from Rv3627c by 2 aa, V45A, V81A; hypothetical protein complement(4038921..4040306) Mycobacterium bovis BCG str. Pasteur 1173P2 4698621 YP_979765.1 CDS ppa NC_008769.1 4040444 4040932 D inorganic pyrophosphatase ppa 4040444..4040932 Mycobacterium bovis BCG str. Pasteur 1173P2 4699299 YP_979766.1 CDS BCG_3687c NC_008769.1 4040978 4042075 R hypothetical protein complement(4040978..4042075) Mycobacterium bovis BCG str. Pasteur 1173P2 4696281 YP_979767.1 CDS BCG_3688 NC_008769.1 4042196 4043491 D Differs from Rv3630 by 1aa, T40A; integral membrane protein 4042196..4043491 Mycobacterium bovis BCG str. Pasteur 1173P2 4699088 YP_979768.1 CDS BCG_3689 NC_008769.1 4043535 4044260 D transferase 4043535..4044260 Mycobacterium bovis BCG str. Pasteur 1173P2 4698518 YP_979769.1 CDS BCG_3690 NC_008769.1 4044257 4044601 D hypothetical protein 4044257..4044601 Mycobacterium bovis BCG str. Pasteur 1173P2 4699296 YP_979770.1 CDS BCG_3691 NC_008769.1 4044812 4045687 D hypothetical protein 4044812..4045687 Mycobacterium bovis BCG str. Pasteur 1173P2 4698226 YP_979771.1 CDS galE1 NC_008769.1 4045688 4046632 R UDP-glucose 4-epimerase complement(4045688..4046632) Mycobacterium bovis BCG str. Pasteur 1173P2 4698843 YP_979772.1 CDS BCG_3693 NC_008769.1 4046655 4048430 D hypothetical protein 4046655..4048430 Mycobacterium bovis BCG str. Pasteur 1173P2 4695530 YP_979773.1 CDS BCG_3694 NC_008769.1 4048773 4049120 D transposase 4048773..4049120 Mycobacterium bovis BCG str. Pasteur 1173P2 4698385 YP_979774.1 CDS BCG_3695 NC_008769.1 4049505 4050005 D transposase 4049505..4050005 Mycobacterium bovis BCG str. Pasteur 1173P2 4698738 YP_979775.1 CDS BCG_3696 NC_008769.1 4050005 4050751 D transposase 4050005..4050751 Mycobacterium bovis BCG str. Pasteur 1173P2 4698551 YP_979776.1 CDS BCG_3697c NC_008769.1 4050905 4051471 R Differs from Rv3639c by 1 aa, N53K; hypothetical protein complement(4050905..4051471) Mycobacterium bovis BCG str. Pasteur 1173P2 4698928 YP_979777.1 CDS BCG_3698c NC_008769.1 4051541 4052770 R Differs from Rv3640c by 1aa, E296G; transposase complement(4051541..4052770) Mycobacterium bovis BCG str. Pasteur 1173P2 4699238 YP_979778.1 CDS fic NC_008769.1 4052946 4053581 R cell filamentation protein fic complement(4052946..4053581) Mycobacterium bovis BCG str. Pasteur 1173P2 4698793 YP_979779.1 CDS BCG_3700c NC_008769.1 4053592 4053786 R hypothetical protein complement(4053592..4053786) Mycobacterium bovis BCG str. Pasteur 1173P2 4695795 YP_979780.1 CDS BCG_3701 NC_008769.1 4054181 4054372 D hypothetical protein 4054181..4054372 Mycobacterium bovis BCG str. Pasteur 1173P2 4698384 YP_979781.1 CDS BCG_3702c NC_008769.1 4054537 4055742 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' complement(4054537..4055742) Mycobacterium bovis BCG str. Pasteur 1173P2 4698406 YP_979782.1 CDS BCG_3703 NC_008769.1 4055828 4057477 D hypothetical protein 4055828..4057477 Mycobacterium bovis BCG str. Pasteur 1173P2 4699236 YP_979783.1 CDS topA NC_008769.1 4057474 4060278 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I complement(4057474..4060278) Mycobacterium bovis BCG str. Pasteur 1173P2 4698825 YP_979784.1 CDS BCG_3705c NC_008769.1 4060631 4061209 R hypothetical protein complement(4060631..4061209) Mycobacterium bovis BCG str. Pasteur 1173P2 4696388 YP_979785.1 CDS cspA NC_008769.1 4061349 4061552 R cold shock protein A cspA complement(4061349..4061552) Mycobacterium bovis BCG str. Pasteur 1173P2 4698444 YP_979786.1 CDS BCG_3707 NC_008769.1 4061802 4064117 D Differs from Rv3649 by 2aa, P93L, D677G, and from Mb3673 by D677G; helicase 4061802..4064117 Mycobacterium bovis BCG str. Pasteur 1173P2 4697990 YP_979787.1 CDS PE33 NC_008769.1 4064254 4064538 D PE family protein 4064254..4064538 Mycobacterium bovis BCG str. Pasteur 1173P2 4699044 YP_979788.1 CDS BCG_3709 NC_008769.1 4064862 4065899 D hypothetical protein 4064862..4065899 Mycobacterium bovis BCG str. Pasteur 1173P2 4698939 YP_979789.1 CDS PE_PGRS60 NC_008769.1 4066653 4066967 D PE-PGRS family protein 4066653..4066967 Mycobacterium bovis BCG str. Pasteur 1173P2 4698896 YP_979790.1 CDS PE_PGRS61 NC_008769.1 4066961 4067656 D In Mycobacterium tuberculosis strain H37Rv, a frameshift due to an in-frame insertion of 126 bp leads to a longer product than in Mycobacterium bovis, and in Mycobacterium bovis BCG Pasteur. Shorter than Mb3677 due to 18 bp in-frame deletion, removes 6 codons; PE-PGRS family protein 4066961..4067656 Mycobacterium bovis BCG str. Pasteur 1173P2 4699252 YP_979791.1 CDS BCG_3712c NC_008769.1 4067773 4068027 R hypothetical protein complement(4067773..4068027) Mycobacterium bovis BCG str. Pasteur 1173P2 4699253 YP_979792.1 CDS BCG_3713c NC_008769.1 4068113 4068412 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base deletion (c-*) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (99 aa versus 125 aa); hypothetical protein complement(4068113..4068412) Mycobacterium bovis BCG str. Pasteur 1173P2 4698076 YP_979793.1 CDS BCG_3714c NC_008769.1 4068436 4068642 R hypothetical protein complement(4068436..4068642) Mycobacterium bovis BCG str. Pasteur 1173P2 4698805 YP_979794.1 CDS BCG_3715c NC_008769.1 4068652 4069227 R alanine rich membrane protein complement(4068652..4069227) Mycobacterium bovis BCG str. Pasteur 1173P2 4699194 YP_979795.1 CDS BCG_3716c NC_008769.1 4069251 4070051 R hypothetical protein complement(4069251..4070051) Mycobacterium bovis BCG str. Pasteur 1173P2 4699173 YP_979796.1 CDS BCG_3717c NC_008769.1 4070048 4071106 R hypothetical protein complement(4070048..4071106) Mycobacterium bovis BCG str. Pasteur 1173P2 4698318 YP_979797.1 CDS BCG_3718c NC_008769.1 4071208 4072260 R Differs from Rv3660c by 1aa, L30P; hypothetical protein complement(4071208..4072260) Mycobacterium bovis BCG str. Pasteur 1173P2 4699192 YP_979798.1 CDS BCG_3719 NC_008769.1 4072760 4073623 D Differs from Rv3661 by 1aa, P40S; hypothetical protein 4072760..4073623 Mycobacterium bovis BCG str. Pasteur 1173P2 4698484 YP_979799.1 CDS BCG_3720c NC_008769.1 4074378 4075148 R Differs from Rv3662c by 1aa, T34A; hypothetical protein complement(4074378..4075148) Mycobacterium bovis BCG str. Pasteur 1173P2 4698916 YP_979800.1 CDS dppD NC_008769.1 4075145 4076791 R dipeptide-transport ATP-binding protein ABC transporter dppD complement(4075145..4076791) Mycobacterium bovis BCG str. Pasteur 1173P2 4698898 YP_979801.1 CDS dppC NC_008769.1 4076788 4077588 R dipeptide-transport integral membrane protein ABC transporter dppC complement(4076788..4077588) Mycobacterium bovis BCG str. Pasteur 1173P2 4698802 YP_979802.1 CDS dppB NC_008769.1 4077644 4078570 R dipeptide-transport integral membrane protein ABC transporter dppB complement(4077644..4078570) Mycobacterium bovis BCG str. Pasteur 1173P2 4696481 YP_979803.1 CDS dppA NC_008769.1 4078572 4080197 R Differs from Rv3666c by 2aa, R4Q, Q443R and to Mb3690c by 1aa, E451G; periplasmic dipeptide-binding lipoprotein dppA complement(4078572..4080197) Mycobacterium bovis BCG str. Pasteur 1173P2 4697939 YP_979804.1 CDS acs NC_008769.1 4080905 4082860 D Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 4080905..4082860 Mycobacterium bovis BCG str. Pasteur 1173P2 4698601 YP_979805.1 CDS BCG_3726c NC_008769.1 4082896 4083594 R protease complement(4082896..4083594) Mycobacterium bovis BCG str. Pasteur 1173P2 4695637 YP_979806.1 CDS BCG_3727 NC_008769.1 4083940 4084458 D hypothetical protein 4083940..4084458 Mycobacterium bovis BCG str. Pasteur 1173P2 4698522 YP_979807.1 CDS ephE NC_008769.1 4084459 4085442 D epoxide hydrolase ephE 4084459..4085442 Mycobacterium bovis BCG str. Pasteur 1173P2 4698769 YP_979808.1 CDS BCG_3729c NC_008769.1 4085435 4086628 R Differs from Rv3671c by 3aa, T165N, L359F, V363I and from Mb3695c by 3aa, T165N and L359F; membrane-associated serine protease complement(4085435..4086628) Mycobacterium bovis BCG str. Pasteur 1173P2 4695460 YP_979809.1 CDS BCG_3730c NC_008769.1 4086634 4087455 R hypothetical protein complement(4086634..4087455) Mycobacterium bovis BCG str. Pasteur 1173P2 4697404 YP_979810.1 CDS BCG_3731c NC_008769.1 4087587 4088270 R membrane-anchored thioredoxin-like protein complement(4087587..4088270) Mycobacterium bovis BCG str. Pasteur 1173P2 4698365 YP_979811.1 CDS nth NC_008769.1 4088270 4089007 R endonuclease III nth complement(4088270..4089007) Mycobacterium bovis BCG str. Pasteur 1173P2 4698863 YP_979812.1 CDS BCG_3733 NC_008769.1 4089115 4089492 D hypothetical protein 4089115..4089492 Mycobacterium bovis BCG str. Pasteur 1173P2 4699184 YP_979813.1 CDS BCG_3734 NC_008769.1 4089591 4090265 D Differs from Rv3676 and Mb 3700 by 2aa, P47L, K178E; CRP/FNR family transcriptional regulator 4089591..4090265 Mycobacterium bovis BCG str. Pasteur 1173P2 4698730 YP_979814.1 CDS BCG_3735c NC_008769.1 4090371 4091165 R hydrolase complement(4090371..4091165) Mycobacterium bovis BCG str. Pasteur 1173P2 4699042 YP_979815.1 CDS BCG_3736c NC_008769.1 4091172 4091627 R hypothetical protein complement(4091172..4091627) Mycobacterium bovis BCG str. Pasteur 1173P2 4699280 YP_979816.1 CDS BCG_3737c NC_008769.1 4091643 4091804 R hypothetical protein complement(4091643..4091804) Mycobacterium bovis BCG str. Pasteur 1173P2 4699315 YP_979817.1 CDS BCG_3738 NC_008769.1 4091889 4092911 D anion transporter atpase 4091889..4092911 Mycobacterium bovis BCG str. Pasteur 1173P2 4699311 YP_979818.1 CDS BCG_3739 NC_008769.1 4092908 4094068 D anion transporter atpase 4092908..4094068 Mycobacterium bovis BCG str. Pasteur 1173P2 4699291 YP_979819.1 CDS whiB4 NC_008769.1 4094311 4094667 R transcriptional regulatory protein whiB-like whiB4 complement(4094311..4094667) Mycobacterium bovis BCG str. Pasteur 1173P2 4699288 YP_979820.1 CDS ponA2 NC_008769.1 4095029 4097461 D bifunctional membrane-associated penicillin-binding protein 1A/1B ponA2 4095029..4097461 Mycobacterium bovis BCG str. Pasteur 1173P2 4697343 YP_979821.1 CDS BCG_3742 NC_008769.1 4097530 4098489 D hypothetical protein 4097530..4098489 Mycobacterium bovis BCG str. Pasteur 1173P2 4696280 YP_979822.1 CDS BCG_3743 NC_008769.1 4098552 4099592 D lyase 4098552..4099592 Mycobacterium bovis BCG str. Pasteur 1173P2 4699318 YP_979823.1 CDS cyp137 NC_008769.1 4100408 4101838 R Differs from Rv3685c by 1aa, Q136E; cytochrome P450 137 cyp137 complement(4100408..4101838) Mycobacterium bovis BCG str. Pasteur 1173P2 4695950 YP_979824.1 CDS BCG_3745c NC_008769.1 4101864 4102196 R hypothetical protein complement(4101864..4102196) Mycobacterium bovis BCG str. Pasteur 1173P2 4697464 YP_979825.1 CDS BCG_3746c NC_008769.1 4102436 4102681 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, truncation at the 5' start due to a single base transversion (g-t) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (81 aa versus 122 aa); hypothetical protein complement(4102436..4102681) Mycobacterium bovis BCG str. Pasteur 1173P2 4698668 YP_979826.1 CDS BCG_3747c NC_008769.1 4103006 4103470 R hypothetical protein complement(4103006..4103470) Mycobacterium bovis BCG str. Pasteur 1173P2 4698117 YP_979827.1 CDS BCG_3748 NC_008769.1 4103470 4104825 D Differs from Rv3689 by 1aa, L119V; hypothetical protein 4103470..4104825 Mycobacterium bovis BCG str. Pasteur 1173P2 4698401 YP_979828.1 CDS BCG_3749 NC_008769.1 4104852 4105505 D hypothetical protein 4104852..4105505 Mycobacterium bovis BCG str. Pasteur 1173P2 4698431 YP_979829.1 CDS BCG_3750 NC_008769.1 4105631 4106632 D hypothetical protein 4105631..4106632 Mycobacterium bovis BCG str. Pasteur 1173P2 4698416 YP_979830.1 CDS moxR2 NC_008769.1 4106629 4107705 D methanol dehydrogenase transcriptional regulatory protein moxR2 4106629..4107705 Mycobacterium bovis BCG str. Pasteur 1173P2 4698409 YP_979831.1 CDS BCG_3752 NC_008769.1 4107839 4109161 D hypothetical protein 4107839..4109161 Mycobacterium bovis BCG str. Pasteur 1173P2 4698909 YP_979832.1 CDS BCG_3753c NC_008769.1 4109235 4110227 R hypothetical protein complement(4109235..4110227) Mycobacterium bovis BCG str. Pasteur 1173P2 4698400 YP_979833.1 CDS BCG_3754 NC_008769.1 4110319 4111251 D hypothetical protein 4110319..4111251 Mycobacterium bovis BCG str. Pasteur 1173P2 4698397 YP_979834.1 CDS glpK NC_008769.1 4111315 4112871 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(4111315..4112871) Mycobacterium bovis BCG str. Pasteur 1173P2 4698362 YP_979835.1 CDS BCG_3756c NC_008769.1 4112921 4113358 R Differs from Rv3697c by 1aa, R34G; hypothetical protein complement(4112921..4113358) Mycobacterium bovis BCG str. Pasteur 1173P2 4697771 YP_979836.1 CDS BCG_3756A NC_008769.1 4113355 4113579 R antitoxin complement(4113355..4113579) Mycobacterium bovis BCG str. Pasteur 1173P2 4697978 YP_979837.1 CDS BCG_3757 NC_008769.1 4113609 4115138 D Differs from Rv3698 by 3aa, I66M, R233P, A288V and from Mb3724 by 1aa, A288V; hypothetical protein 4113609..4115138 Mycobacterium bovis BCG str. Pasteur 1173P2 4698391 YP_979838.1 CDS BCG_3758 NC_008769.1 4115160 4115861 D hypothetical protein 4115160..4115861 Mycobacterium bovis BCG str. Pasteur 1173P2 4698410 YP_979839.1 CDS BCG_3759c NC_008769.1 4115864 4117036 R hypothetical protein complement(4115864..4117036) Mycobacterium bovis BCG str. Pasteur 1173P2 4698386 YP_979840.1 CDS BCG_3760c NC_008769.1 4117067 4118032 R hypothetical protein complement(4117067..4118032) Mycobacterium bovis BCG str. Pasteur 1173P2 4698042 YP_979841.1 CDS BCG_3761c NC_008769.1 4118029 4118730 R hypothetical protein complement(4118029..4118730) Mycobacterium bovis BCG str. Pasteur 1173P2 4698387 YP_979842.1 CDS BCG_3762c NC_008769.1 4118730 4120007 R hypothetical protein complement(4118730..4120007) Mycobacterium bovis BCG str. Pasteur 1173P2 4698390 YP_979843.1 CDS gshA NC_008769.1 4120004 4121302 R glutamate--cysteine ligase complement(4120004..4121302) Mycobacterium bovis BCG str. Pasteur 1173P2 4698389 YP_979844.1 CDS BCG_3764c NC_008769.1 4121434 4122078 R hypothetical protein complement(4121434..4122078) Mycobacterium bovis BCG str. Pasteur 1173P2 4697813 YP_979845.1 CDS BCG_3765c NC_008769.1 4122207 4122596 R hypothetical protein complement(4122207..4122596) Mycobacterium bovis BCG str. Pasteur 1173P2 4698089 YP_979846.1 CDS BCG_3766c NC_008769.1 4122707 4123027 R hypothetical protein complement(4122707..4123027) Mycobacterium bovis BCG str. Pasteur 1173P2 4698204 YP_979847.1 CDS BCG_3767c NC_008769.1 4123146 4124156 R hypothetical protein complement(4123146..4124156) Mycobacterium bovis BCG str. Pasteur 1173P2 4698369 YP_979848.1 CDS asd NC_008769.1 4124296 4125333 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(4124296..4125333) Mycobacterium bovis BCG str. Pasteur 1173P2 4698017 YP_979849.1 CDS ask NC_008769.1 4125334 4126599 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase complement(4125334..4126599) Mycobacterium bovis BCG str. Pasteur 1173P2 4697830 YP_979850.1 CDS leuA NC_008769.1 4126856 4129360 D Protein is 190 aa longer than Rv3710, and 57 aa longer than Mb3737 due to differences in copy number of 19 codon repeat at 3'-end; 2-isopropylmalate synthase 4126856..4129360 Mycobacterium bovis BCG str. Pasteur 1173P2 4698566 YP_979851.1 CDS dnaQ NC_008769.1 4129426 4130415 R 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon complement(4129426..4130415) Mycobacterium bovis BCG str. Pasteur 1173P2 4695958 YP_979852.1 CDS BCG_3772 NC_008769.1 4130549 4131790 D Differs from Rv3712 by 2aa, S200G, T351K; ligase 4130549..4131790 Mycobacterium bovis BCG str. Pasteur 1173P2 4699060 YP_979853.1 CDS cobQ2 NC_008769.1 4131795 4132490 D cobyric acid synthase cobQ2 4131795..4132490 Mycobacterium bovis BCG str. Pasteur 1173P2 4698018 YP_979854.1 CDS BCG_3774c NC_008769.1 4132499 4133389 R hypothetical protein complement(4132499..4133389) Mycobacterium bovis BCG str. Pasteur 1173P2 4699359 YP_979855.1 CDS recR NC_008769.1 4133457 4134068 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(4133457..4134068) Mycobacterium bovis BCG str. Pasteur 1173P2 4698177 YP_979856.1 CDS BCG_3776c NC_008769.1 4134080 4134481 R hypothetical protein complement(4134080..4134481) Mycobacterium bovis BCG str. Pasteur 1173P2 4695840 YP_979857.1 CDS BCG_3777 NC_008769.1 4134616 4135341 D hypothetical protein 4134616..4135341 Mycobacterium bovis BCG str. Pasteur 1173P2 4698374 YP_979858.1 CDS BCG_3778c NC_008769.1 4135383 4135826 R hypothetical protein complement(4135383..4135826) Mycobacterium bovis BCG str. Pasteur 1173P2 4698375 YP_979859.1 CDS BCG_3779 NC_008769.1 4135874 4137286 D Differs from Rv3719 by 1aa, A12T; hypothetical protein 4135874..4137286 Mycobacterium bovis BCG str. Pasteur 1173P2 4698377 YP_979860.1 CDS BCG_3780 NC_008769.1 4137304 4138566 D fatty acid synthase 4137304..4138566 Mycobacterium bovis BCG str. Pasteur 1173P2 4698372 YP_979861.1 CDS dnaZX NC_008769.1 4138563 4140299 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau complement(4138563..4140299) Mycobacterium bovis BCG str. Pasteur 1173P2 4698367 YP_979862.1 CDS BCG_3782c NC_008769.1 4140389 4141696 R Differs from Rv3722c and Mb3749c by 1aa, Y314H; hypothetical protein complement(4140389..4141696) Mycobacterium bovis BCG str. Pasteur 1173P2 4696771 YP_979863.1 CDS BCG_3783 NC_008769.1 4142104 4142868 D hypothetical protein 4142104..4142868 Mycobacterium bovis BCG str. Pasteur 1173P2 4698403 YP_979864.1 CDS cut5 NC_008769.1 4143035 4143736 D In Mycobacterium tuberculosis, Rv3724A and Rv3724B exist as 2 genes with an overlap region between them. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a single base deletion (t-*) leads to a single product; cutinase precursor cut5 4143035..4143736 Mycobacterium bovis BCG str. Pasteur 1173P2 4698370 YP_979865.1 CDS BCG_3785 NC_008769.1 4143781 4144782 D In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a single base insertion (*-a) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (333 aa versus 309 aa); oxidoreductase 4143781..4144782 Mycobacterium bovis BCG str. Pasteur 1173P2 4695572 YP_979866.1 CDS BCG_3786 NC_008769.1 4144989 4146182 D Differs from Rv3726 by 1aa, S251R; dehydrogenase 4144989..4146182 Mycobacterium bovis BCG str. Pasteur 1173P2 4698361 YP_979867.1 CDS BCG_3787 NC_008769.1 4146523 4148331 D Differs from Rv3727 by 1aa, M86V; oxidoreductase 4146523..4148331 Mycobacterium bovis BCG str. Pasteur 1173P2 4698354 YP_979868.1 CDS BCG_3788 NC_008769.1 4148441 4151638 D Differs from Rv3728 by 1aa, R464G; hypothetical protein 4148441..4151638 Mycobacterium bovis BCG str. Pasteur 1173P2 4698359 YP_979869.1 CDS BCG_3789 NC_008769.1 4151853 4154183 D Differs from Rv3729 by 2aa, I170V, S269P; transferase 4151853..4154183 Mycobacterium bovis BCG str. Pasteur 1173P2 4698353 YP_979870.1 CDS BCG_3790c NC_008769.1 4154248 4155288 R hypothetical protein complement(4154248..4155288) Mycobacterium bovis BCG str. Pasteur 1173P2 4698356 YP_979871.1 CDS ligC NC_008769.1 4155326 4156402 D catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth; ATP-dependent DNA ligase 4155326..4156402 Mycobacterium bovis BCG str. Pasteur 1173P2 4698355 YP_979872.1 CDS BCG_3792 NC_008769.1 4156502 4157560 D hypothetical protein 4156502..4157560 Mycobacterium bovis BCG str. Pasteur 1173P2 4698685 YP_979873.1 CDS BCG_3793c NC_008769.1 4157580 4158080 R hypothetical protein complement(4157580..4158080) Mycobacterium bovis BCG str. Pasteur 1173P2 4698346 YP_979874.1 CDS BCG_3794c NC_008769.1 4158094 4159458 R hypothetical protein complement(4158094..4159458) Mycobacterium bovis BCG str. Pasteur 1173P2 4698336 YP_979875.1 CDS BCG_3795 NC_008769.1 4159657 4160145 D hypothetical protein 4159657..4160145 Mycobacterium bovis BCG str. Pasteur 1173P2 4698352 YP_979876.1 CDS BCG_3796 NC_008769.1 4160202 4161263 D Differs from Rv3736 and Mb3763 by 1aa, K76E; AraC family transcriptional regulator 4160202..4161263 Mycobacterium bovis BCG str. Pasteur 1173P2 4698381 YP_979877.1 CDS BCG_3797 NC_008769.1 4161267 4162856 D Differs from Rv3737 by 1aa, G40D; hypothetical protein 4161267..4162856 Mycobacterium bovis BCG str. Pasteur 1173P2 4698351 YP_979878.1 CDS BCG_3799c NC_008769.1 4163235 4164581 R Differs from Rv3740c by 1aa, C422R; hypothetical protein complement(4163235..4164581) Mycobacterium bovis BCG str. Pasteur 1173P2 4697699 YP_979879.1 CDS BCG_3800c NC_008769.1 4164581 4165255 R oxidoreductase complement(4164581..4165255) Mycobacterium bovis BCG str. Pasteur 1173P2 4698343 YP_979880.1 CDS BCG_3801c NC_008769.1 4165252 4165647 R oxidoreductase complement(4165252..4165647) Mycobacterium bovis BCG str. Pasteur 1173P2 4698337 YP_979881.1 CDS ctpJ NC_008769.1 4165793 4167775 R cation transporter P-type atpase ctpJ complement(4165793..4167775) Mycobacterium bovis BCG str. Pasteur 1173P2 4698093 YP_979882.1 CDS BCG_3803 NC_008769.1 4167842 4168204 D ArsR family transcriptional regulator 4167842..4168204 Mycobacterium bovis BCG str. Pasteur 1173P2 4696477 YP_979883.1 CDS BCG_3804c NC_008769.1 4168288 4168500 R hypothetical protein complement(4168288..4168500) Mycobacterium bovis BCG str. Pasteur 1173P2 4698332 YP_979884.1 CDS PE34 NC_008769.1 4168573 4168908 R PE family protein complement(4168573..4168908) Mycobacterium bovis BCG str. Pasteur 1173P2 4698331 YP_979885.1 CDS BCG_3806 NC_008769.1 4169126 4169509 D hypothetical protein 4169126..4169509 Mycobacterium bovis BCG str. Pasteur 1173P2 4698940 YP_979886.1 CDS BCG_3807 NC_008769.1 4169639 4169998 D Differs from Rv3748 by 1aa, D107G; hypothetical protein 4169639..4169998 Mycobacterium bovis BCG str. Pasteur 1173P2 4698330 YP_979887.1 CDS BCG_3808c NC_008769.1 4170031 4170540 R hypothetical protein complement(4170031..4170540) Mycobacterium bovis BCG str. Pasteur 1173P2 4698334 YP_979888.1 CDS BCG_3809c NC_008769.1 4170608 4171000 R excisionase complement(4170608..4171000) Mycobacterium bovis BCG str. Pasteur 1173P2 4698137 YP_979889.1 CDS BCG_3810 NC_008769.1 4171276 4171491 D integrase 4171276..4171491 Mycobacterium bovis BCG str. Pasteur 1173P2 4698324 YP_979890.1 CDS BCG_3811c NC_008769.1 4171649 4172107 R cytidine/deoxycytidylate deaminase complement(4171649..4172107) Mycobacterium bovis BCG str. Pasteur 1173P2 4698404 YP_979891.1 CDS BCG_3812c NC_008769.1 4172123 4172644 R In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a single base transition (t-c) leads to a longer product with a different 5' start compared to its homolog in Mycobacterium tuberculosis strain H37Rv (173 aa versus 166 aa); hypothetical protein complement(4172123..4172644) Mycobacterium bovis BCG str. Pasteur 1173P2 4698321 YP_979892.1 CDS tyrA NC_008769.1 4172823 4173728 D catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 4172823..4173728 Mycobacterium bovis BCG str. Pasteur 1173P2 4698304 YP_979893.1 CDS BCG_3814c NC_008769.1 4173691 4174290 R hypothetical protein complement(4173691..4174290) Mycobacterium bovis BCG str. Pasteur 1173P2 4696863 YP_979894.1 CDS proZ NC_008769.1 4174296 4175015 R osmoprotectant (glycine betaine/carnitine/choline/l-proline) transport integral membrane protein ABC transporter proZ complement(4174296..4175015) Mycobacterium bovis BCG str. Pasteur 1173P2 4698305 YP_979895.1 CDS proW NC_008769.1 4175012 4175701 R osmoprotectant (glycine betaine/carnitine/choline/l-proline) transport integral membrane protein ABC transporter proW complement(4175012..4175701) Mycobacterium bovis BCG str. Pasteur 1173P2 4697275 YP_979896.1 CDS proV NC_008769.1 4175689 4176819 R osmoprotectant (glycine betaine/carnitine/choline/l-proline) transport ATP-binding protein ABC transporter proV complement(4175689..4176819) Mycobacterium bovis BCG str. Pasteur 1173P2 4696517 YP_979897.1 CDS proX NC_008769.1 4176828 4177775 R Differs from Rv3759c by 2aa, P85L, V176A; osmoprotectant (glycine betaine/carnitine/choline/l-proline) binding lipoprotein proX complement(4176828..4177775) Mycobacterium bovis BCG str. Pasteur 1173P2 4696516 YP_979898.1 CDS BCG_3819 NC_008769.1 4177940 4178242 D hypothetical protein 4177940..4178242 Mycobacterium bovis BCG str. Pasteur 1173P2 4696518 YP_979899.1 CDS fadE36 NC_008769.1 4178264 4179319 R acyl-CoA dehydrogenase fadE36 complement(4178264..4179319) Mycobacterium bovis BCG str. Pasteur 1173P2 4698311 YP_979900.1 CDS BCG_3821c NC_008769.1 4179398 4181278 R Differs from Rv3762c by 1aa, H345Y and from Mb3788c by 1aa, V161G; hydrolase complement(4179398..4181278) Mycobacterium bovis BCG str. Pasteur 1173P2 4695635 YP_979901.1 CDS lpqH NC_008769.1 4181449 4181928 D 19 kDa lipoprotein antigen precursor lpqH 4181449..4181928 Mycobacterium bovis BCG str. Pasteur 1173P2 4698020 YP_979902.1 CDS BCG_3823c NC_008769.1 4181984 4183411 R Differs from Rv3764c by 2aa, R45H, R246C; two component sensor kinase complement(4181984..4183411) Mycobacterium bovis BCG str. Pasteur 1173P2 4698155 YP_979903.1 CDS BCG_3824c NC_008769.1 4183482 4184186 R two component transcriptional regulator complement(4183482..4184186) Mycobacterium bovis BCG str. Pasteur 1173P2 4698301 YP_979904.1 CDS BCG_3825 NC_008769.1 4184695 4185384 D hypothetical protein 4184695..4185384 Mycobacterium bovis BCG str. Pasteur 1173P2 4698292 YP_979905.1 CDS BCG_3826c NC_008769.1 4185398 4186342 R hypothetical protein complement(4185398..4186342) Mycobacterium bovis BCG str. Pasteur 1173P2 4698297 YP_979906.1 CDS BCG_3827 NC_008769.1 4186472 4186831 D hypothetical protein 4186472..4186831 Mycobacterium bovis BCG str. Pasteur 1173P2 4698300 YP_979907.1 CDS BCG_3828 NC_008769.1 4187017 4187289 D hypothetical protein 4187017..4187289 Mycobacterium bovis BCG str. Pasteur 1173P2 4698302 YP_979908.1 CDS BCG_3829c NC_008769.1 4187602 4188177 R Differs from Rv3770c by 1aa, A98P; hypothetical protein complement(4187602..4188177) Mycobacterium bovis BCG str. Pasteur 1173P2 4698298 YP_979909.1 CDS BCG_3830c NC_008769.1 4188283 4188465 R remnant of a transposase complement(4188283..4188465) Mycobacterium bovis BCG str. Pasteur 1173P2 4698285 YP_979910.1 CDS BCG_3831c NC_008769.1 4188480 4188671 R remnant of a transposase complement(4188480..4188671) Mycobacterium bovis BCG str. Pasteur 1173P2 4698288 YP_979911.1 CDS BCG_3832c NC_008769.1 4188806 4189132 R hypothetical protein complement(4188806..4189132) Mycobacterium bovis BCG str. Pasteur 1173P2 4698287 YP_979912.1 CDS hisC2 NC_008769.1 4189536 4190597 D Differs from Rv3772 by 1aa, A142T; aminotransferase 4189536..4190597 Mycobacterium bovis BCG str. Pasteur 1173P2 4695951 YP_979913.1 CDS BCG_3834c NC_008769.1 4190643 4190987 R In Mycobacterium tuberculosis Rv3773c exists as a single gene. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-a) splits Rv3773c in two parts; hypothetical protein complement(4190643..4190987) Mycobacterium bovis BCG str. Pasteur 1173P2 4696167 YP_979914.1 CDS BCG_3835c NC_008769.1 4190992 4191228 R In Mycobacterium tuberculosis strain H37Rv, Rv3773c exists as a single gene. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-a) splits Rv3773c into 2 parts; hypothetical protein complement(4190992..4191228) Mycobacterium bovis BCG str. Pasteur 1173P2 4698176 YP_979915.1 CDS echA21 NC_008769.1 4191252 4192076 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 4191252..4192076 Mycobacterium bovis BCG str. Pasteur 1173P2 4698295 YP_979916.1 CDS lipE NC_008769.1 4192088 4193335 D lipase lipE 4192088..4193335 Mycobacterium bovis BCG str. Pasteur 1173P2 4697251 YP_979917.1 CDS BCG_3838 NC_008769.1 4193492 4195051 D Differs from Rv3776 by 1aa, V329M; hypothetical protein 4193492..4195051 Mycobacterium bovis BCG str. Pasteur 1173P2 4698084 YP_979918.1 CDS BCG_3839 NC_008769.1 4195097 4196083 D Differs from Rv3777 by 1aa, A160V; oxidoreductase 4195097..4196083 Mycobacterium bovis BCG str. Pasteur 1173P2 4698402 YP_979919.1 CDS BCG_3840c NC_008769.1 4196102 4197298 R aminotransferase complement(4196102..4197298) Mycobacterium bovis BCG str. Pasteur 1173P2 4698282 YP_979920.1 CDS BCG_3841 NC_008769.1 4197388 4199388 D transmembrane protein alanine and leucine rich 4197388..4199388 Mycobacterium bovis BCG str. Pasteur 1173P2 4698291 YP_979921.1 CDS BCG_3842 NC_008769.1 4199392 4199928 D hypothetical protein 4199392..4199928 Mycobacterium bovis BCG str. Pasteur 1173P2 4698673 YP_979922.1 CDS rbfE NC_008769.1 4199932 4200753 D O-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter rfbE 4199932..4200753 Mycobacterium bovis BCG str. Pasteur 1173P2 4698296 YP_979923.1 CDS BCG_3844 NC_008769.1 4200750 4201664 D L-rhamnosyltransferase 4200750..4201664 Mycobacterium bovis BCG str. Pasteur 1173P2 4697307 YP_979924.1 CDS rfbD NC_008769.1 4201661 4202503 D O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter rfbD 4201661..4202503 Mycobacterium bovis BCG str. Pasteur 1173P2 4698159 YP_979925.1 CDS rfbB NC_008769.1 4202659 4203639 D dTDP-glucose 4,6-dehydratase rfbB 4202659..4203639 Mycobacterium bovis BCG str. Pasteur 1173P2 4696797 YP_979926.1 CDS BCG_3847 NC_008769.1 4203723 4204796 D hypothetical protein 4203723..4204796 Mycobacterium bovis BCG str. Pasteur 1173P2 4696796 YP_979927.1 CDS BCG_3848c NC_008769.1 4204777 4206000 R hypothetical protein complement(4204777..4206000) Mycobacterium bovis BCG str. Pasteur 1173P2 4698270 YP_979928.1 CDS BCG_3849c NC_008769.1 4206013 4206939 R hypothetical protein complement(4206013..4206939) Mycobacterium bovis BCG str. Pasteur 1173P2 4698283 YP_979929.1 CDS BCG_3850 NC_008769.1 4207183 4207668 D Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 4207183..4207668 Mycobacterium bovis BCG str. Pasteur 1173P2 4698286 YP_979930.1 CDS BCG_3851 NC_008769.1 4207777 4208142 D hypothetical protein 4207777..4208142 Mycobacterium bovis BCG str. Pasteur 1173P2 4698278 YP_979931.1 CDS BCG_3852 NC_008769.1 4208182 4209567 D oxidoreductase 4208182..4209567 Mycobacterium bovis BCG str. Pasteur 1173P2 4698083 YP_979932.1 CDS BCG_3853 NC_008769.1 4209568 4210332 D short chain dehydrogenase 4209568..4210332 Mycobacterium bovis BCG str. Pasteur 1173P2 4698118 YP_979933.1 CDS BCG_3854 NC_008769.1 4210335 4212266 D hypothetical protein 4210335..4212266 Mycobacterium bovis BCG str. Pasteur 1173P2 4698115 YP_979934.1 CDS embC NC_008769.1 4212266 4215550 D Differs from Rv3793 by 1aa, I270T; integral membrane indolylacetylinositol arabinosyltransferase embC 4212266..4215550 Mycobacterium bovis BCG str. Pasteur 1173P2 4698561 YP_979935.1 CDS embA NC_008769.1 4215636 4218920 D integral membrane indolylacetylinositol arabinosyltransferase embA 4215636..4218920 Mycobacterium bovis BCG str. Pasteur 1173P2 4697214 YP_979936.1 CDS embB NC_008769.1 4218917 4222213 D Differs from Rv3795 by 2aa, S13N, A378E; integral membrane indolylacetylinositol arabinosyltransferase embB 4218917..4222213 Mycobacterium bovis BCG str. Pasteur 1173P2 4697919 YP_979937.1 CDS BCG_3858 NC_008769.1 4222281 4223408 D Differs from Rv3796 by 1aa, I320T; hypothetical protein 4222281..4223408 Mycobacterium bovis BCG str. Pasteur 1173P2 4695907 YP_979938.1 CDS fadE35 NC_008769.1 4223488 4225269 D acyl-CoA dehydrogenase fadE35 4223488..4225269 Mycobacterium bovis BCG str. Pasteur 1173P2 4698276 YP_979939.1 CDS BCG_3860 NC_008769.1 4225396 4226730 D In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur, BCG_3860 and Rv3798 exist as a single gene. In Mycobacterium bovis, a frameshift due to a 11 bp deletion splits Rv3798 into 2 parts, Mb3827 and Mb3828; In Mycobacterium bovis, a frameshift due to a 11 bp deletion splits Rv3798 into 2 parts, Mb3827 and Mb3828; transposase 4225396..4226730 Mycobacterium bovis BCG str. Pasteur 1173P2 4695634 YP_979940.1 CDS accD4 NC_008769.1 4226783 4228351 R propionyl-CoA carboxylase beta chain 4 accD4 complement(4226783..4228351) Mycobacterium bovis BCG str. Pasteur 1173P2 4698603 YP_979941.1 CDS pks13 NC_008769.1 4228348 4233549 R Differs from Rv3800c by 2aa, G523A, N650S and from Mb3829c by 1aa, N650S; polyketide synthase complement(4228348..4233549) Mycobacterium bovis BCG str. Pasteur 1173P2 4698784 YP_979942.1 CDS fadD32 NC_008769.1 4233556 4235469 R activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(4233556..4235469) Mycobacterium bovis BCG str. Pasteur 1173P2 4698457 YP_979943.1 CDS BCG_3864c NC_008769.1 4235758 4236768 R hypothetical protein complement(4235758..4236768) Mycobacterium bovis BCG str. Pasteur 1173P2 4698948 YP_979944.1 CDS fbpD NC_008769.1 4236966 4237865 R hypothetical protein complement(4236966..4237865) Mycobacterium bovis BCG str. Pasteur 1173P2 4698569 YP_979945.1 CDS fbpA NC_008769.1 4238045 4239061 R hypothetical protein complement(4238045..4239061) Mycobacterium bovis BCG str. Pasteur 1173P2 4696523 YP_979946.1 CDS BCG_3867c NC_008769.1 4239356 4241239 R Differs from Rv3805c by 1aa, V327I; hypothetical protein complement(4239356..4241239) Mycobacterium bovis BCG str. Pasteur 1173P2 4696564 YP_979947.1 CDS BCG_3868c NC_008769.1 4241328 4242236 R catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate; phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase complement(4241328..4242236) Mycobacterium bovis BCG str. Pasteur 1173P2 4698675 YP_979948.1 CDS BCG_3869c NC_008769.1 4242243 4242740 R hypothetical protein complement(4242243..4242740) Mycobacterium bovis BCG str. Pasteur 1173P2 4698606 YP_979949.1 CDS BCG_3870c NC_008769.1 4242769 4244682 R galactofuranosyl transferase complement(4242769..4244682) Mycobacterium bovis BCG str. Pasteur 1173P2 4699166 YP_979950.1 CDS glf NC_008769.1 4244679 4245878 R UDP-galactopyranose mutase complement(4244679..4245878) Mycobacterium bovis BCG str. Pasteur 1173P2 4696780 YP_979951.1 CDS pirG NC_008769.1 4246142 4246996 D hypothetical protein 4246142..4246996 Mycobacterium bovis BCG str. Pasteur 1173P2 4697399 YP_979952.1 CDS BCG_3873 NC_008769.1 4247201 4248820 D hypothetical protein 4247201..4248820 Mycobacterium bovis BCG str. Pasteur 1173P2 4699305 YP_979953.1 CDS PE_PGRS62 NC_008769.1 4248974 4250488 D PE-PGRS family protein 4248974..4250488 Mycobacterium bovis BCG str. Pasteur 1173P2 4699336 YP_979954.1 CDS BCG_3875c NC_008769.1 4250797 4251618 R Differs from Rv3813c by 1aa, T83M; hypothetical protein complement(4250797..4251618) Mycobacterium bovis BCG str. Pasteur 1173P2 4699254 YP_979955.1 CDS BCG_3876c NC_008769.1 4251633 4252418 R acyltransferase complement(4251633..4252418) Mycobacterium bovis BCG str. Pasteur 1173P2 4699269 YP_979956.1 CDS BCG_3877c NC_008769.1 4252436 4253191 R acyltransferase complement(4252436..4253191) Mycobacterium bovis BCG str. Pasteur 1173P2 4698695 YP_979957.1 CDS BCG_3878c NC_008769.1 4253195 4253974 R acyltransferase complement(4253195..4253974) Mycobacterium bovis BCG str. Pasteur 1173P2 4696537 YP_979958.1 CDS BCG_3879 NC_008769.1 4254050 4254805 D phosphotransferase 4254050..4254805 Mycobacterium bovis BCG str. Pasteur 1173P2 4699024 YP_979959.1 CDS BCG_3880 NC_008769.1 4254852 4256402 D hypothetical protein 4254852..4256402 Mycobacterium bovis BCG str. Pasteur 1173P2 4697921 YP_979960.1 CDS BCG_3881 NC_008769.1 4256399 4256734 D hypothetical protein 4256399..4256734 Mycobacterium bovis BCG str. Pasteur 1173P2 4698164 YP_979961.1 CDS papA2 NC_008769.1 4256822 4258228 R Differs from Rv3820c by 1aa, I463T; polyketide synthase associated protein papA2 complement(4256822..4258228) Mycobacterium bovis BCG str. Pasteur 1173P2 4698002 YP_979962.1 CDS BCG_3883 NC_008769.1 4258376 4259089 D Differs from Rv3821 by 2aa, N106D, T120A; integral membrane protein 4258376..4259089 Mycobacterium bovis BCG str. Pasteur 1173P2 4698055 YP_979963.1 CDS BCG_3884 NC_008769.1 4259124 4259492 D Corresponds to Rv3822/Mb3852 but is missing 1bp after codon 122. Differs from Rv3822 by 2aa, Y55C, T103N, in first part (and by 1aa , V92A, in the second part); hypothetical protein 4259124..4259492 Mycobacterium bovis BCG str. Pasteur 1173P2 4698082 YP_979964.1 CDS BCG_3885 NC_008769.1 4259489 4260337 D Corresponds to 3'-part of Rv3822/Mb3852 due to missing bp after codon 122. Differs from Rv3822 by 1aa, V92A (and by 2aa, Y55C, T105N, in first part; hypothetical protein 4259489..4260337 Mycobacterium bovis BCG str. Pasteur 1173P2 4698148 YP_979965.1 CDS mmpL8 NC_008769.1 4260662 4263931 R Differs from Rv3823c by 2aa, R235G, A526V; integral membrane transport protein mmpL8 complement(4260662..4263931) Mycobacterium bovis BCG str. Pasteur 1173P2 4698033 YP_979966.1 CDS papA1 NC_008769.1 4264041 4265576 R polyketide synthase associated protein papA1 complement(4264041..4265576) Mycobacterium bovis BCG str. Pasteur 1173P2 4696174 YP_979967.1 CDS pks2 NC_008769.1 4265627 4272007 R Differs from Rv3825c and Mb3855c by 1aa, G829V; polyketide synthase complement(4265627..4272007) Mycobacterium bovis BCG str. Pasteur 1173P2 4698054 YP_979968.1 CDS fadD23 NC_008769.1 4272214 4273968 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 4272214..4273968 Mycobacterium bovis BCG str. Pasteur 1173P2 4698460 YP_979969.1 CDS BCG_3890c NC_008769.1 4273965 4275191 R Differs from Rv3827c by 1aa, A251T; transposase complement(4273965..4275191) Mycobacterium bovis BCG str. Pasteur 1173P2 4695672 YP_979970.1 CDS BCG_3891c NC_008769.1 4275188 4275799 R resolvase complement(4275188..4275799) Mycobacterium bovis BCG str. Pasteur 1173P2 4698676 YP_979971.1 CDS BCG_3892c NC_008769.1 4275800 4277410 R Differs from Rv3829c by 1aa, D54E; dehydrogenase complement(4275800..4277410) Mycobacterium bovis BCG str. Pasteur 1173P2 4698080 YP_979972.1 CDS BCG_3893c NC_008769.1 4277458 4278087 R TetR family transcriptional regulator complement(4277458..4278087) Mycobacterium bovis BCG str. Pasteur 1173P2 4698071 YP_979973.1 CDS BCG_3894 NC_008769.1 4278159 4278641 D hypothetical protein 4278159..4278641 Mycobacterium bovis BCG str. Pasteur 1173P2 4698081 YP_979974.1 CDS BCG_3895c NC_008769.1 4278638 4279213 R hypothetical protein complement(4278638..4279213) Mycobacterium bovis BCG str. Pasteur 1173P2 4698045 YP_979975.1 CDS BCG_3896 NC_008769.1 4279269 4280060 D Differs from Rv3833 by 1aa, I105V; AraC family transcriptional regulator 4279269..4280060 Mycobacterium bovis BCG str. Pasteur 1173P2 4698026 YP_979976.1 CDS serS NC_008769.1 4280057 4281316 R catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase complement(4280057..4281316) Mycobacterium bovis BCG str. Pasteur 1173P2 4698062 YP_979977.1 CDS BCG_3898 NC_008769.1 4281449 4282807 D Differs from Rv3835 and Mb3865 by 1 aa, Y79N, and frameshift due to extra C in C-string that changes C-terminus; hypothetical protein 4281449..4282807 Mycobacterium bovis BCG str. Pasteur 1173P2 4696252 YP_979978.1 CDS BCG_3899 NC_008769.1 4282804 4283154 D In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a single base insertion (*-g) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (116 aa versus 137 aa); hypothetical protein 4282804..4283154 Mycobacterium bovis BCG str. Pasteur 1173P2 4698061 YP_979979.1 CDS BCG_3900c NC_008769.1 4283413 4284111 R phosphoglycerate mutase complement(4283413..4284111) Mycobacterium bovis BCG str. Pasteur 1173P2 4698032 YP_979980.1 CDS pheA NC_008769.1 4284108 4285073 R catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase complement(4284108..4285073) Mycobacterium bovis BCG str. Pasteur 1173P2 4698041 YP_979981.1 CDS BCG_3902 NC_008769.1 4285169 4285945 D Differs from Rv3839 by 1aa, S122P; hypothetical protein 4285169..4285945 Mycobacterium bovis BCG str. Pasteur 1173P2 4698859 YP_979982.1 CDS BCG_3903 NC_008769.1 4285971 4286384 D transcriptional regulatory protein 4285971..4286384 Mycobacterium bovis BCG str. Pasteur 1173P2 4698019 YP_979983.1 CDS bfrB NC_008769.1 4286582 4287127 D bacterioferritin bfrB 4286582..4287127 Mycobacterium bovis BCG str. Pasteur 1173P2 4698038 YP_979984.1 CDS glpQ1 NC_008769.1 4287142 4287966 R glycerophosphoryl diester phosphodiesterase glpQ1 complement(4287142..4287966) Mycobacterium bovis BCG str. Pasteur 1173P2 4696666 YP_979985.1 CDS BCG_3906c NC_008769.1 4287972 4289000 R Differs from Rv3843c by 2aa, R11G, H92R; hypothetical protein complement(4287972..4289000) Mycobacterium bovis BCG str. Pasteur 1173P2 4697772 YP_979986.1 CDS BCG_3907 NC_008769.1 4291178 4291669 D transposase 4291178..4291669 Mycobacterium bovis BCG str. Pasteur 1173P2 4698007 YP_979987.1 CDS BCG_3908 NC_008769.1 4291684 4292043 D hypothetical protein 4291684..4292043 Mycobacterium bovis BCG str. Pasteur 1173P2 4698012 YP_979988.1 CDS sodA NC_008769.1 4293107 4293730 D Differs from Rv3846 by 1aa, T205I; superoxide dismutase [Fe] sodA 4293107..4293730 Mycobacterium bovis BCG str. Pasteur 1173P2 4697999 YP_979989.1 CDS BCG_3910 NC_008769.1 4293941 4294474 D hypothetical protein 4293941..4294474 Mycobacterium bovis BCG str. Pasteur 1173P2 4697293 YP_979990.1 CDS BCG_3911 NC_008769.1 4294729 4295637 D Differs from Rv3848 by 1aa, I194V; hypothetical protein 4294729..4295637 Mycobacterium bovis BCG str. Pasteur 1173P2 4698004 YP_979991.1 CDS BCG_3912 NC_008769.1 4295902 4296300 D hypothetical protein 4295902..4296300 Mycobacterium bovis BCG str. Pasteur 1173P2 4697975 YP_979992.1 CDS BCG_3913 NC_008769.1 4296418 4297074 D hypothetical protein 4296418..4297074 Mycobacterium bovis BCG str. Pasteur 1173P2 4697906 YP_979993.1 CDS BCG_3914 NC_008769.1 4297086 4297370 D hypothetical protein 4297086..4297370 Mycobacterium bovis BCG str. Pasteur 1173P2 4695458 YP_979994.1 CDS hns NC_008769.1 4297477 4297881 D histone-like protein hns 4297477..4297881 Mycobacterium bovis BCG str. Pasteur 1173P2 4699355 YP_979995.1 CDS menG NC_008769.1 4297898 4298371 D regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 4297898..4298371 Mycobacterium bovis BCG str. Pasteur 1173P2 4696101 YP_979996.1 CDS ethA NC_008769.1 4298407 4299876 R monooxygenase ethA complement(4298407..4299876) Mycobacterium bovis BCG str. Pasteur 1173P2 4696113 YP_979997.1 CDS ethR NC_008769.1 4299952 4300602 D TetR family transcriptional regulator 4299952..4300602 Mycobacterium bovis BCG str. Pasteur 1173P2 4696340 YP_979998.1 CDS BCG_3919c NC_008769.1 4300804 4301811 R hypothetical protein complement(4300804..4301811) Mycobacterium bovis BCG str. Pasteur 1173P2 4696363 YP_979999.1 CDS BCG_3920c NC_008769.1 4301820 4302017 R hypothetical protein complement(4301820..4302017) Mycobacterium bovis BCG str. Pasteur 1173P2 4699337 YP_980000.1 CDS gltD NC_008769.1 4302442 4303908 R glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta complement(4302442..4303908) Mycobacterium bovis BCG str. Pasteur 1173P2 4699323 YP_980001.1 CDS gltB NC_008769.1 4303901 4308484 R Differs from Rv3859c by 1aa, E553Q; ferredoxin-dependent glutamate synthase large subunit GltB complement(4303901..4308484) Mycobacterium bovis BCG str. Pasteur 1173P2 4696572 YP_980002.1 CDS BCG_3923 NC_008769.1 4309180 4310241 D In Mycobacterium bovis BCG Pasteur, a single base deletion leads to a shorter product compared to its homologs in Mycobacterium tuberculosis and Mycobacterium bovis; hypothetical protein 4309180..4310241 Mycobacterium bovis BCG str. Pasteur 1173P2 4696571 YP_980003.1 CDS BCG_3924 NC_008769.1 4310348 4310674 D hypothetical protein 4310348..4310674 Mycobacterium bovis BCG str. Pasteur 1173P2 4699320 YP_980004.1 CDS whiB6 NC_008769.1 4310573 4310923 R transcriptional regulatory protein whiB-like whiB6 complement(4310573..4310923) Mycobacterium bovis BCG str. Pasteur 1173P2 4699285 YP_980005.1 CDS BCG_3926 NC_008769.1 4311250 4312428 D hypothetical protein 4311250..4312428 Mycobacterium bovis BCG str. Pasteur 1173P2 4697345 YP_980006.1 CDS BCG_3927 NC_008769.1 4312671 4313927 D In Mycobacterium bovis BCG Pasteur, and in Mycobacterium bovis, two in-frame insertion of 36 and 12 bp, leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (418 aa versus 402 aa); hypothetical protein 4312671..4313927 Mycobacterium bovis BCG str. Pasteur 1173P2 4699278 YP_980007.1 CDS BCG_3928 NC_008769.1 4314015 4314326 D hypothetical protein 4314015..4314326 Mycobacterium bovis BCG str. Pasteur 1173P2 4699289 YP_980008.1 CDS BCG_3929 NC_008769.1 4314329 4315180 D hypothetical protein 4314329..4315180 Mycobacterium bovis BCG str. Pasteur 1173P2 4699310 YP_980009.1 CDS BCG_3930 NC_008769.1 4315219 4315770 D hypothetical protein 4315219..4315770 Mycobacterium bovis BCG str. Pasteur 1173P2 4699287 YP_980010.1 CDS BCG_3931 NC_008769.1 4315763 4317484 D Differs from Rv3868 by 1aa, V243A; hypothetical protein 4315763..4317484 Mycobacterium bovis BCG str. Pasteur 1173P2 4699301 YP_980011.1 CDS BCG_3932 NC_008769.1 4317488 4318930 D hypothetical protein 4317488..4318930 Mycobacterium bovis BCG str. Pasteur 1173P2 4699272 YP_980012.1 CDS BCG_3933 NC_008769.1 4318930 4321173 D hypothetical protein 4318930..4321173 Mycobacterium bovis BCG str. Pasteur 1173P2 4699250 YP_980013.1 CDS BCG_3934 NC_008769.1 4321276 4322748 D Differs from Rv3871 and Mb3901 by deletion of 101 codons after codon 480 due to BCG-specific RD1 deletion; hypothetical protein 4321276..4322748 Mycobacterium bovis BCG str. Pasteur 1173P2 4699246 YP_980014.1 CDS BCG_3935c NC_008769.1 4323191 4323538 R hypothetical protein complement(4323191..4323538) Mycobacterium bovis BCG str. Pasteur 1173P2 4699247 YP_980015.1 CDS BCG_3936c NC_008769.1 4323535 4324917 R Differs from Rv3881c by 7 codon stretch due to 1bp deletion and 1 bp insertion; hypothetical protein complement(4323535..4324917) Mycobacterium bovis BCG str. Pasteur 1173P2 4699243 YP_980016.1 CDS BCG_3937c NC_008769.1 4325024 4326412 R hypothetical protein complement(4325024..4326412) Mycobacterium bovis BCG str. Pasteur 1173P2 4699127 YP_980017.1 CDS BCG_3938c NC_008769.1 4326409 4327749 R Differs from Rv3883c by 1aa, A37T; protease complement(4326409..4327749) Mycobacterium bovis BCG str. Pasteur 1173P2 4699188 YP_980018.1 CDS BCG_3939c NC_008769.1 4327971 4329830 R Differs from Rv3884c by 1aa, G215E; hypothetical protein complement(4327971..4329830) Mycobacterium bovis BCG str. Pasteur 1173P2 4699102 YP_980019.1 CDS BCG_3940c NC_008769.1 4329900 4331513 R Differs from Rv3885c by 1aa, P133L; hypothetical protein complement(4329900..4331513) Mycobacterium bovis BCG str. Pasteur 1173P2 4699116 YP_980020.1 CDS BCG_3941c NC_008769.1 4331510 4333162 R hypothetical protein complement(4331510..4333162) Mycobacterium bovis BCG str. Pasteur 1173P2 4699074 YP_980021.1 CDS BCG_3942c NC_008769.1 4333147 4334676 R In Mycobacterium bovis, a deletion of 2406 bp (RDpan) leads to the loss of the NH2 part of Rv3887c, the entire Rv3888c and the COOH part of Rv3889c compared to Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur. Differs from Mb3917c by 1aa D346G; hypothetical protein complement(4333147..4334676) Mycobacterium bovis BCG str. Pasteur 1173P2 4699093 YP_980022.1 CDS BCG_3943c NC_008769.1 4334673 4335335 R Has no counterpart in Mycobacterium bovis owing to deletion of 2405bp between positions 4307384..4307385; hypothetical protein complement(4334673..4335335) Mycobacterium bovis BCG str. Pasteur 1173P2 4699071 YP_980023.1 CDS BCG_3944c NC_008769.1 4335332 4335697 R Has no counterpart in Mycobacterium bovis owing to deletion of 2405bp between positions 364165-364166; hypothetical protein complement(4335332..4335697) Mycobacterium bovis BCG str. Pasteur 1173P2 4699058 YP_980024.1 CDS BCG_3945c NC_008769.1 4335791 4336621 R In Mycobacterium bovis, a deletion of 2406 bases leads to the loss of the NH2 part of Rv3887c, the entire Rv3888c and the COOH part of Rv3889c compared to Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur; hypothetical protein complement(4335791..4336621) Mycobacterium bovis BCG str. Pasteur 1173P2 4699056 YP_980025.1 CDS esxC NC_008769.1 4336629 4337003 R In Mycobacterium bovis BCG Pasteur, and in Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (124 aa versus 95 aa); ESAT-6 like protein 11 esxC complement(4336629..4337003) Mycobacterium bovis BCG str. Pasteur 1173P2 4699365 YP_980026.1 CDS esxD NC_008769.1 4337039 4337362 R Differs from Rv3891c by 1aa, A49T; hypothetical protein complement(4337039..4337362) Mycobacterium bovis BCG str. Pasteur 1173P2 4696382 YP_980027.1 CDS PPE69 NC_008769.1 4337473 4338672 R Differs from Rv3892c by 2aa, K19T, I206M and from Mb3921c by 1aa I206M; PPE family protein complement(4337473..4338672) Mycobacterium bovis BCG str. Pasteur 1173P2 4695418 YP_980028.1 CDS PE36 NC_008769.1 4338751 4338984 R PE family protein complement(4338751..4338984) Mycobacterium bovis BCG str. Pasteur 1173P2 4697700 YP_980029.1 CDS BCG_3950c NC_008769.1 4339251 4340936 R In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-c), splits Rv3894c into 2 parts; hypothetical protein complement(4339251..4340936) Mycobacterium bovis BCG str. Pasteur 1173P2 4698941 YP_980030.1 CDS BCG_3951c NC_008769.1 4340941 4343442 R In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a single base insertion (*-c), splits Rv3894c into 2 parts. Differs from first part of Rv3984c by 1aa, P258R; hypothetical protein complement(4340941..4343442) Mycobacterium bovis BCG str. Pasteur 1173P2 4698517 YP_980031.1 CDS BCG_3952c NC_008769.1 4343443 4344930 R Differs from Rv3895c by 1aa, G356D; hypothetical protein complement(4343443..4344930) Mycobacterium bovis BCG str. Pasteur 1173P2 4698237 YP_980032.1 CDS BCG_3953c NC_008769.1 4344974 4345840 R Differs from Rv3896c by 3aa, G83D, V186I, K193Q, and by frameshift due to 1bp deletion leading to shorter product (288aa versus 302aa); hypothetical protein complement(4344974..4345840) Mycobacterium bovis BCG str. Pasteur 1173P2 4699262 YP_980033.1 CDS BCG_3954c NC_008769.1 4345990 4346979 R In Mycobacterium tuberculosis, Rv3898c and Rv3897c exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur, a single base transition (t-c) leads to a single product; hypothetical protein complement(4345990..4346979) Mycobacterium bovis BCG str. Pasteur 1173P2 4699284 YP_980034.1 CDS BCG_3955c NC_008769.1 4347141 4348022 R In Mycobacterium tuberculosis, Rv3899c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur a frameshift due to a single base deletion (c-*) splits Rv3899c into 2 parts, Mb3928c and Mb3929c with the former being the more likely product; hypothetical protein complement(4347141..4348022) Mycobacterium bovis BCG str. Pasteur 1173P2 4698234 YP_980035.1 CDS BCG_3957c NC_008769.1 4348366 4349301 R Differs from Rv3900c by 1aa, A18P; hypothetical protein complement(4348366..4349301) Mycobacterium bovis BCG str. Pasteur 1173P2 4698132 YP_980036.1 CDS BCG_3958c NC_008769.1 4349410 4349805 R Differs from Rv3901c by 1aa, W21L, and frameshift due to 2bp deletion at 3'-end, and from Mb3931c by frameshift only; hypothetical protein complement(4349410..4349805) Mycobacterium bovis BCG str. Pasteur 1173P2 4698366 YP_980037.1 CDS BCG_3959c NC_008769.1 4350356 4350886 R hypothetical protein complement(4350356..4350886) Mycobacterium bovis BCG str. Pasteur 1173P2 4699193 YP_980038.1 CDS BCG_3960c NC_008769.1 4350883 4353423 R hypothetical protein complement(4350883..4353423) Mycobacterium bovis BCG str. Pasteur 1173P2 4698509 YP_980039.1 CDS esxE NC_008769.1 4353428 4353700 R Differs from Rv3904c by 1aa, V82M; ESAT-6 like protein 12 esxE complement(4353428..4353700) Mycobacterium bovis BCG str. Pasteur 1173P2 4699350 YP_980040.1 CDS esxF NC_008769.1 4353849 4354022 R In Mycobacterium bovis, and M.bovis BCG Pasteur, a single base transition (g-a) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (57 aa versus 103 aa); ESAT-6 like protein 13 esxF complement(4353849..4354022) Mycobacterium bovis BCG str. Pasteur 1173P2 4695412 YP_980041.1 CDS BCG_3963c NC_008769.1 4354088 4354597 R hypothetical protein complement(4354088..4354597) Mycobacterium bovis BCG str. Pasteur 1173P2 4697926 YP_980042.1 CDS pcnA NC_008769.1 4354622 4356064 R poly(A) polymerase complement(4354622..4356064) Mycobacterium bovis BCG str. Pasteur 1173P2 4699371 YP_980043.1 CDS BCG_3965 NC_008769.1 4356440 4357186 D hypothetical protein 4356440..4357186 Mycobacterium bovis BCG str. Pasteur 1173P2 4698419 YP_980044.1 CDS BCG_3966 NC_008769.1 4357183 4359591 D Differs from Rv3909 by 3aa, R7G, S399N, V538A and from Mb3939 by 1aa G25A; hypothetical protein 4357183..4359591 Mycobacterium bovis BCG str. Pasteur 1173P2 4698463 YP_980045.1 CDS BCG_3967 NC_008769.1 4359588 4363142 D Differs from Rv3910 by 1aa, A480V; hypothetical protein 4359588..4363142 Mycobacterium bovis BCG str. Pasteur 1173P2 4698553 YP_980046.1 CDS sigMa_1 NC_008769.1 4363177 4363767 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase; RNA polymerase sigma factor SigM 4363177..4363767 Mycobacterium bovis BCG str. Pasteur 1173P2 4698556 YP_980047.1 CDS BCG_3970 NC_008769.1 4363860 4364624 D hypothetical protein 4363860..4364624 Mycobacterium bovis BCG str. Pasteur 1173P2 4696447 YP_980048.1 CDS trxB2_1 NC_008769.1 4364718 4365725 D Differs from Rv3913 by 1aa, G57D; thioredoxin reductase trxB2 4364718..4365725 Mycobacterium bovis BCG str. Pasteur 1173P2 4698549 YP_980049.1 CDS trxC_1 NC_008769.1 4365722 4366072 D thioredoxin trxC 4365722..4366072 Mycobacterium bovis BCG str. Pasteur 1173P2 4696833 YP_980050.1 CDS BCG_3973 NC_008769.1 4366182 4367402 D hydrolase 4366182..4367402 Mycobacterium bovis BCG str. Pasteur 1173P2 4697087 YP_980051.1 CDS BCG_3974c NC_008769.1 4367423 4368157 R hypothetical protein complement(4367423..4368157) Mycobacterium bovis BCG str. Pasteur 1173P2 4698559 YP_980052.1 CDS parB_1 NC_008769.1 4368447 4369481 R chromosome partitioning protein parB complement(4368447..4369481) Mycobacterium bovis BCG str. Pasteur 1173P2 4698570 YP_980053.1 CDS parA_1 NC_008769.1 4369478 4370521 R chromosome partitioning protein parA complement(4369478..4370521) Mycobacterium bovis BCG str. Pasteur 1173P2 4697550 YP_980054.1 CDS gidB NC_008769.1 4370518 4371192 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(4370518..4371192) Mycobacterium bovis BCG str. Pasteur 1173P2 4697548 YP_980055.1 CDS BCG_3978c NC_008769.1 4371324 4371887 R Differs from Rv3920c by 1aa, W110R; hypothetical protein complement(4371324..4371887) Mycobacterium bovis BCG str. Pasteur 1173P2 4698649 YP_980056.1 CDS BCG_3979c NC_008769.1 4371959 4373059 R functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC complement(4371959..4373059) Mycobacterium bovis BCG str. Pasteur 1173P2 4698562 YP_980057.1 CDS BCG_3980c NC_008769.1 4373043 4373405 R hypothetical protein complement(4373043..4373405) Mycobacterium bovis BCG str. Pasteur 1173P2 4698575 YP_980058.1 CDS rnpA NC_008769.1 4373402 4373779 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(4373402..4373779) Mycobacterium bovis BCG str. Pasteur 1173P2 4698573 YP_980059.1 CDS rpmH NC_008769.1 4373776 4373919 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(4373776..4373919) Mycobacterium bovis BCG str. Pasteur 1173P2 4697609 BCG_ileT_1 tRNA tRNA-Ile NC_008769.1 10887 10960 D tRNA-Ile 10887..10960 Mycobacterium bovis BCG str. Pasteur 1173P2 4696536 BCG_alaT_1 tRNA tRNA-Ala NC_008769.1 11112 11184 D tRNA-Ala 11112..11184 Mycobacterium bovis BCG str. Pasteur 1173P2 4696332 BCG_ileT_2 tRNA tRNA-Ile NC_008769.1 40554 40627 D tRNA-Ile 40554..40627 Mycobacterium bovis BCG str. Pasteur 1173P2 4697762 BCG_alaT_2 tRNA tRNA-Ala NC_008769.1 40779 40851 D tRNA-Ala 40779..40851 Mycobacterium bovis BCG str. Pasteur 1173P2 4696333 BCG_t01 tRNA tRNA-Leu NC_008769.1 55292 55374 D tRNA-Leu 55292..55374 Mycobacterium bovis BCG str. Pasteur 1173P2 4696424 BCG_t02 tRNA tRNA-Gly NC_008769.1 417131 417201 R tRNA-Gly complement(417131..417201) Mycobacterium bovis BCG str. Pasteur 1173P2 4696568 BCG_t03 tRNA tRNA-Tyr NC_008769.1 689000 689080 D tRNA-Tyr 689000..689080 Mycobacterium bovis BCG str. Pasteur 1173P2 4695971 BCG_t04 tRNA tRNA-Thr NC_008769.1 762370 762442 D tRNA-Thr 762370..762442 Mycobacterium bovis BCG str. Pasteur 1173P2 4697359 BCG_t05 tRNA tRNA-Met NC_008769.1 762479 762552 D tRNA-Met 762479..762552 Mycobacterium bovis BCG str. Pasteur 1173P2 4698405 BCG_t06 tRNA tRNA-Trp NC_008769.1 764400 764472 D tRNA-Trp 764400..764472 Mycobacterium bovis BCG str. Pasteur 1173P2 4697378 BCG_t07 tRNA tRNA-Thr NC_008769.1 882425 882496 R tRNA-Thr complement(882425..882496) Mycobacterium bovis BCG str. Pasteur 1173P2 4696004 BCG_t08 tRNA tRNA-Lys NC_008769.1 954224 954296 R tRNA-Lys complement(954224..954296) Mycobacterium bovis BCG str. Pasteur 1173P2 4695411 BCG_t09 tRNA tRNA-Glu NC_008769.1 954420 954493 D tRNA-Glu 954420..954493 Mycobacterium bovis BCG str. Pasteur 1173P2 4697282 BCG_t10 tRNA tRNA-Asp NC_008769.1 954531 954604 D tRNA-Asp 954531..954604 Mycobacterium bovis BCG str. Pasteur 1173P2 4696854 BCG_t11 tRNA tRNA-Phe NC_008769.1 954634 954707 D tRNA-Phe 954634..954707 Mycobacterium bovis BCG str. Pasteur 1173P2 4697862 BCG_t12 tRNA tRNA-Arg NC_008769.1 1055796 1055868 R tRNA-Arg complement(1055796..1055868) Mycobacterium bovis BCG str. Pasteur 1173P2 4697675 BCG_t13 tRNA tRNA-Ala NC_008769.1 1144000 1144072 D tRNA-Ala 1144000..1144072 Mycobacterium bovis BCG str. Pasteur 1173P2 4696199 BCG_t14 tRNA tRNA-Gln NC_008769.1 1168561 1168632 R tRNA-Gln complement(1168561..1168632) Mycobacterium bovis BCG str. Pasteur 1173P2 4696208 BCG_t15 tRNA tRNA-Leu NC_008769.1 1207882 1207955 D tRNA-Leu 1207882..1207955 Mycobacterium bovis BCG str. Pasteur 1173P2 4695973 BCG_t16 tRNA tRNA-Arg NC_008769.1 1472720 1472792 R tRNA-Arg complement(1472720..1472792) Mycobacterium bovis BCG str. Pasteur 1173P2 4699309 BCG_t20 tRNA tRNA-Leu NC_008769.1 1539242 1539325 D tRNA-Leu 1539242..1539325 Mycobacterium bovis BCG str. Pasteur 1173P2 4697505 BCG_t21 tRNA tRNA-Leu NC_008769.1 1833262 1833335 R tRNA-Leu complement(1833262..1833335) Mycobacterium bovis BCG str. Pasteur 1173P2 4695389 BCG_t22 tRNA tRNA-Pro NC_008769.1 1951829 1951902 D tRNA-Pro 1951829..1951902 Mycobacterium bovis BCG str. Pasteur 1173P2 4695876 BCG_t23 tRNA tRNA-Leu NC_008769.1 2381997 2382082 D tRNA-Leu 2381997..2382082 Mycobacterium bovis BCG str. Pasteur 1173P2 4698129 BCG_t25 tRNA tRNA-Val NC_008769.1 2489243 2489314 R tRNA-Val complement(2489243..2489314) Mycobacterium bovis BCG str. Pasteur 1173P2 4697715 BCG_t26 tRNA tRNA-Met NC_008769.1 2558859 2558932 R tRNA-Met complement(2558859..2558932) Mycobacterium bovis BCG str. Pasteur 1173P2 4696187 BCG_t27 tRNA tRNA-Asn NC_008769.1 2596504 2596576 R tRNA-Asn complement(2596504..2596576) Mycobacterium bovis BCG str. Pasteur 1173P2 4698709 BCG_t28 tRNA tRNA-Pro NC_008769.1 2730501 2730574 R tRNA-Pro complement(2730501..2730574) Mycobacterium bovis BCG str. Pasteur 1173P2 4695912 BCG_t29 tRNA tRNA-Gly NC_008769.1 2730711 2730781 D tRNA-Gly 2730711..2730781 Mycobacterium bovis BCG str. Pasteur 1173P2 4695949 BCG_t30 tRNA tRNA-Arg NC_008769.1 2757985 2758058 D tRNA-Arg 2757985..2758058 Mycobacterium bovis BCG str. Pasteur 1173P2 4696903 BCG_t31 tRNA tRNA-His NC_008769.1 2791650 2791722 D tRNA-His 2791650..2791722 Mycobacterium bovis BCG str. Pasteur 1173P2 4698921 BCG_t32 tRNA tRNA-Lys NC_008769.1 2799290 2799362 D tRNA-Lys 2799290..2799362 Mycobacterium bovis BCG str. Pasteur 1173P2 4698576 BCG_t33 tRNA tRNA-Val NC_008769.1 2934007 2934078 R tRNA-Val complement(2934007..2934078) Mycobacterium bovis BCG str. Pasteur 1173P2 4698368 BCG_t34 tRNA tRNA-Gly NC_008769.1 2934263 2934335 D tRNA-Gly 2934263..2934335 Mycobacterium bovis BCG str. Pasteur 1173P2 4695655 BCG_t35 tRNA tRNA-Cys NC_008769.1 2934365 2934435 D tRNA-Cys 2934365..2934435 Mycobacterium bovis BCG str. Pasteur 1173P2 4696856 BCG_t36 tRNA tRNA-Val NC_008769.1 2934452 2934523 D tRNA-Val 2934452..2934523 Mycobacterium bovis BCG str. Pasteur 1173P2 4697863 BCG_t37 tRNA tRNA-Glu NC_008769.1 3303034 3303106 R tRNA-Glu complement(3303034..3303106) Mycobacterium bovis BCG str. Pasteur 1173P2 4698260 BCG_t38 tRNA tRNA-Gln NC_008769.1 3303146 3303217 R tRNA-Gln complement(3303146..3303217) Mycobacterium bovis BCG str. Pasteur 1173P2 4696855 BCG_t39 tRNA tRNA-Ala NC_008769.1 3386326 3386398 R tRNA-Ala complement(3386326..3386398) Mycobacterium bovis BCG str. Pasteur 1173P2 4698063 BCG_t41 tRNA tRNA-Met NC_008769.1 3511842 3511915 R tRNA-Met complement(3511842..3511915) Mycobacterium bovis BCG str. Pasteur 1173P2 4698070 BCG_t42 tRNA tRNA-Thr NC_008769.1 4054386 4054458 R tRNA-Thr complement(4054386..4054458) Mycobacterium bovis BCG str. Pasteur 1173P2 4699295 BCG_t43 tRNA tRNA-Pro NC_008769.1 4099654 4099727 D tRNA-Pro 4099654..4099727 Mycobacterium bovis BCG str. Pasteur 1173P2 4699300 BCG_t44 tRNA tRNA-Ser NC_008769.1 4141913 4141998 D tRNA-Ser 4141913..4141998 Mycobacterium bovis BCG str. Pasteur 1173P2 4698373 BCG_t45 tRNA tRNA-Ser NC_008769.1 4171533 4171619 R tRNA-Ser complement(4171533..4171619) Mycobacterium bovis BCG str. Pasteur 1173P2 4698319 BCG_t46 tRNA tRNA-Arg NC_008769.1 4189267 4189339 R tRNA-Arg complement(4189267..4189339) Mycobacterium bovis BCG str. Pasteur 1173P2 4698289 BCG_t47 tRNA tRNA-Ser NC_008769.1 4189370 4189458 R tRNA-Ser complement(4189370..4189458) Mycobacterium bovis BCG str. Pasteur 1173P2 4697083 BCG_t48 tRNA tRNA-Ser NC_008769.1 4194984 4195070 R tRNA-Ser complement(4194984..4195070) Mycobacterium bovis BCG str. Pasteur 1173P2 4698281 BCG_r17 rRNA 16S_rRNA NC_008769.1 1498360 1499896 D 16S ribosomal RNA 1498360..1499896 Mycobacterium bovis BCG str. Pasteur 1173P2 4699151 BCG_r18 rRNA 23S_rRNA NC_008769.1 1500175 1503305 D 23S ribosomal RNA join(1500175..1501762,1501804..1503305) Mycobacterium bovis BCG str. Pasteur 1173P2 4698697 BCG_r19 rRNA 5S_rRNA NC_008769.1 1503413 1503527 D 5S ribosomal RNA 1503413..1503527 Mycobacterium bovis BCG str. Pasteur 1173P2 4698678