-- dump date 20140619_151524 -- class Genbank::misc_feature -- table misc_feature_note -- id note 410289000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 410289000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289000003 Walker A motif; other site 410289000004 ATP binding site [chemical binding]; other site 410289000005 Walker B motif; other site 410289000006 arginine finger; other site 410289000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 410289000008 DnaA box-binding interface [nucleotide binding]; other site 410289000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 410289000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 410289000011 putative DNA binding surface [nucleotide binding]; other site 410289000012 dimer interface [polypeptide binding]; other site 410289000013 beta-clamp/clamp loader binding surface; other site 410289000014 beta-clamp/translesion DNA polymerase binding surface; other site 410289000015 recF protein; Region: recf; TIGR00611 410289000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 410289000017 Walker A/P-loop; other site 410289000018 ATP binding site [chemical binding]; other site 410289000019 Q-loop/lid; other site 410289000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289000021 ABC transporter signature motif; other site 410289000022 Walker B; other site 410289000023 D-loop; other site 410289000024 H-loop/switch region; other site 410289000025 hypothetical protein; Provisional; Region: PRK03195 410289000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 410289000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 410289000028 Mg2+ binding site [ion binding]; other site 410289000029 G-X-G motif; other site 410289000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 410289000031 anchoring element; other site 410289000032 dimer interface [polypeptide binding]; other site 410289000033 ATP binding site [chemical binding]; other site 410289000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 410289000035 active site 410289000036 putative metal-binding site [ion binding]; other site 410289000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 410289000038 DNA gyrase subunit A; Validated; Region: PRK05560 410289000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 410289000040 CAP-like domain; other site 410289000041 active site 410289000042 primary dimer interface [polypeptide binding]; other site 410289000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 410289000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 410289000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 410289000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 410289000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 410289000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 410289000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 410289000050 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 410289000051 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 410289000052 active site 410289000053 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 410289000054 putative septation inhibitor protein; Reviewed; Region: PRK00159 410289000055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 410289000056 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 410289000057 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 410289000058 Glutamine amidotransferase class-I; Region: GATase; pfam00117 410289000059 glutamine binding [chemical binding]; other site 410289000060 catalytic triad [active] 410289000061 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 410289000062 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 410289000063 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 410289000064 DNA binding residues [nucleotide binding] 410289000065 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 410289000066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 410289000067 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 410289000068 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 410289000069 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 410289000070 catalytic residues [active] 410289000071 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 410289000072 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 410289000073 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 410289000074 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 410289000075 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 410289000076 active site 410289000077 metal binding site [ion binding]; metal-binding site 410289000078 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 410289000079 ParB-like nuclease domain; Region: ParB; smart00470 410289000080 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 410289000081 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 410289000082 P-loop; other site 410289000083 Magnesium ion binding site [ion binding]; other site 410289000084 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 410289000085 Magnesium ion binding site [ion binding]; other site 410289000086 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 410289000087 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 410289000088 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 410289000089 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 410289000090 G-X-X-G motif; other site 410289000091 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 410289000092 RxxxH motif; other site 410289000093 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 410289000094 Uncharacterized conserved protein [Function unknown]; Region: COG0759 410289000095 ribonuclease P; Reviewed; Region: rnpA; PRK00588 410289000096 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 410289000097 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 410289000098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289000099 Walker A motif; other site 410289000100 ATP binding site [chemical binding]; other site 410289000101 Walker B motif; other site 410289000102 arginine finger; other site 410289000103 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 410289000104 DnaA box-binding interface [nucleotide binding]; other site 410289000105 DNA polymerase III subunit beta; Validated; Region: PRK07761 410289000106 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 410289000107 putative DNA binding surface [nucleotide binding]; other site 410289000108 dimer interface [polypeptide binding]; other site 410289000109 beta-clamp/clamp loader binding surface; other site 410289000110 beta-clamp/translesion DNA polymerase binding surface; other site 410289000111 recF protein; Region: recf; TIGR00611 410289000112 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 410289000113 Walker A/P-loop; other site 410289000114 ATP binding site [chemical binding]; other site 410289000115 Q-loop/lid; other site 410289000116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289000117 ABC transporter signature motif; other site 410289000118 Walker B; other site 410289000119 D-loop; other site 410289000120 H-loop/switch region; other site 410289000121 hypothetical protein; Provisional; Region: PRK03195 410289000122 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 410289000123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 410289000124 Mg2+ binding site [ion binding]; other site 410289000125 G-X-G motif; other site 410289000126 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 410289000127 anchoring element; other site 410289000128 dimer interface [polypeptide binding]; other site 410289000129 ATP binding site [chemical binding]; other site 410289000130 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 410289000131 active site 410289000132 putative metal-binding site [ion binding]; other site 410289000133 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 410289000134 DNA gyrase subunit A; Validated; Region: PRK05560 410289000135 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 410289000136 CAP-like domain; other site 410289000137 active site 410289000138 primary dimer interface [polypeptide binding]; other site 410289000139 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 410289000140 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 410289000141 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 410289000142 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 410289000143 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 410289000144 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 410289000145 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 410289000146 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 410289000147 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 410289000148 active site 410289000149 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 410289000150 putative septation inhibitor protein; Reviewed; Region: PRK00159 410289000151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 410289000152 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 410289000153 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 410289000154 Glutamine amidotransferase class-I; Region: GATase; pfam00117 410289000155 glutamine binding [chemical binding]; other site 410289000156 catalytic triad [active] 410289000157 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 410289000158 Catalytic domain of Protein Kinases; Region: PKc; cd00180 410289000159 active site 410289000160 ATP binding site [chemical binding]; other site 410289000161 substrate binding site [chemical binding]; other site 410289000162 activation loop (A-loop); other site 410289000163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 410289000164 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 410289000165 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 410289000166 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 410289000167 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 410289000168 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 410289000169 Catalytic domain of Protein Kinases; Region: PKc; cd00180 410289000170 active site 410289000171 ATP binding site [chemical binding]; other site 410289000172 substrate binding site [chemical binding]; other site 410289000173 activation loop (A-loop); other site 410289000174 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 410289000175 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 410289000176 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 410289000177 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 410289000178 active site 410289000179 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 410289000180 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 410289000181 phosphopeptide binding site; other site 410289000182 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 410289000183 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 410289000184 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 410289000185 phosphopeptide binding site; other site 410289000186 Nitronate monooxygenase; Region: NMO; pfam03060 410289000187 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 410289000188 FMN binding site [chemical binding]; other site 410289000189 substrate binding site [chemical binding]; other site 410289000190 putative catalytic residue [active] 410289000191 Transcription factor WhiB; Region: Whib; pfam02467 410289000192 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 410289000193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 410289000194 non-specific DNA binding site [nucleotide binding]; other site 410289000195 salt bridge; other site 410289000196 sequence-specific DNA binding site [nucleotide binding]; other site 410289000197 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 410289000198 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 410289000199 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 410289000200 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 410289000201 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 410289000202 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 410289000203 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 410289000204 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 410289000205 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 410289000206 catalytic residue [active] 410289000207 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 410289000208 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 410289000209 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 410289000210 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 410289000211 acyl-activating enzyme (AAE) consensus motif; other site 410289000212 active site 410289000213 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 410289000214 H+ Antiporter protein; Region: 2A0121; TIGR00900 410289000215 hypothetical protein; Validated; Region: PRK00228 410289000216 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 410289000217 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 410289000218 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 410289000219 active site 410289000220 HIGH motif; other site 410289000221 nucleotide binding site [chemical binding]; other site 410289000222 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 410289000223 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 410289000224 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 410289000225 active site 410289000226 KMSKS motif; other site 410289000227 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 410289000228 tRNA binding surface [nucleotide binding]; other site 410289000229 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 410289000230 MarR family; Region: MarR; pfam01047 410289000231 Transcriptional regulators [Transcription]; Region: FadR; COG2186 410289000232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 410289000233 DNA-binding site [nucleotide binding]; DNA binding site 410289000234 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 410289000235 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 410289000236 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 410289000237 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 410289000238 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 410289000239 Predicted transcriptional regulators [Transcription]; Region: COG1695 410289000240 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 410289000241 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 410289000242 Transglycosylase; Region: Transgly; pfam00912 410289000243 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 410289000244 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 410289000245 Predicted integral membrane protein [Function unknown]; Region: COG5650 410289000246 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 410289000247 conserved cys residue [active] 410289000248 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 410289000249 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 410289000250 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 410289000251 dimer interface [polypeptide binding]; other site 410289000252 ssDNA binding site [nucleotide binding]; other site 410289000253 tetramer (dimer of dimers) interface [polypeptide binding]; other site 410289000254 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 410289000255 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 410289000256 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 410289000257 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 410289000258 replicative DNA helicase; Validated; Region: PRK07773 410289000259 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 410289000260 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 410289000261 Walker A motif; other site 410289000262 ATP binding site [chemical binding]; other site 410289000263 Walker B motif; other site 410289000264 DNA binding loops [nucleotide binding] 410289000265 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 410289000266 protein-splicing catalytic site; other site 410289000267 thioester formation/cholesterol transfer; other site 410289000268 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 410289000269 protein-splicing catalytic site; other site 410289000270 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 410289000271 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 410289000272 ADP-ribose binding site [chemical binding]; other site 410289000273 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 410289000274 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 410289000275 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 410289000276 FAD binding domain; Region: FAD_binding_4; pfam01565 410289000277 Berberine and berberine like; Region: BBE; pfam08031 410289000278 hypothetical protein; Provisional; Region: PRK12438 410289000279 hypothetical protein; Validated; Region: PRK00068 410289000280 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 410289000281 homotetrameric interface [polypeptide binding]; other site 410289000282 putative active site [active] 410289000283 metal binding site [ion binding]; metal-binding site 410289000284 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 410289000285 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 410289000286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289000287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289000288 short chain dehydrogenase; Provisional; Region: PRK06197 410289000289 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 410289000290 putative NAD(P) binding site [chemical binding]; other site 410289000291 active site 410289000292 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 410289000293 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 410289000294 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 410289000295 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 410289000296 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 410289000297 dimer interface [polypeptide binding]; other site 410289000298 active site 410289000299 glycine-pyridoxal phosphate binding site [chemical binding]; other site 410289000300 folate binding site [chemical binding]; other site 410289000301 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 410289000302 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 410289000303 putative NTP binding site [chemical binding]; other site 410289000304 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 410289000305 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 410289000306 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 410289000307 Walker A/P-loop; other site 410289000308 ATP binding site [chemical binding]; other site 410289000309 Q-loop/lid; other site 410289000310 ABC transporter signature motif; other site 410289000311 Walker B; other site 410289000312 D-loop; other site 410289000313 H-loop/switch region; other site 410289000314 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 410289000315 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 410289000316 ligand binding site [chemical binding]; other site 410289000317 flexible hinge region; other site 410289000318 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 410289000319 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 410289000320 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 410289000321 active site 410289000322 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 410289000323 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 410289000324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289000325 homodimer interface [polypeptide binding]; other site 410289000326 catalytic residue [active] 410289000327 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 410289000328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289000329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289000330 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 410289000331 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 410289000332 dimerization interface [polypeptide binding]; other site 410289000333 putative DNA binding site [nucleotide binding]; other site 410289000334 putative Zn2+ binding site [ion binding]; other site 410289000335 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 410289000336 hydrogenase 4 subunit B; Validated; Region: PRK06521 410289000337 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 410289000338 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 410289000339 NADH dehydrogenase; Region: NADHdh; cl00469 410289000340 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 410289000341 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 410289000342 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 410289000343 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 410289000344 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 410289000345 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 410289000346 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 410289000347 putative hydrophobic ligand binding site [chemical binding]; other site 410289000348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289000349 S-adenosylmethionine binding site [chemical binding]; other site 410289000350 Predicted membrane protein [Function unknown]; Region: COG3305 410289000351 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 410289000352 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 410289000353 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 410289000354 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 410289000355 metal-binding site [ion binding] 410289000356 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 410289000357 Soluble P-type ATPase [General function prediction only]; Region: COG4087 410289000358 Predicted integral membrane protein [Function unknown]; Region: COG5660 410289000359 Putative zinc-finger; Region: zf-HC2; pfam13490 410289000360 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289000361 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289000362 active site 410289000363 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289000364 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289000365 PPE family; Region: PPE; pfam00823 410289000366 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 410289000367 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 410289000368 FcoT-like thioesterase domain; Region: FcoT; pfam10862 410289000369 acyl-CoA synthetase; Validated; Region: PRK05857 410289000370 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289000371 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 410289000372 acyl-activating enzyme (AAE) consensus motif; other site 410289000373 acyl-activating enzyme (AAE) consensus motif; other site 410289000374 AMP binding site [chemical binding]; other site 410289000375 active site 410289000376 CoA binding site [chemical binding]; other site 410289000377 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 410289000378 AMP-binding enzyme; Region: AMP-binding; pfam00501 410289000379 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289000380 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289000381 acyl-activating enzyme (AAE) consensus motif; other site 410289000382 acyl-activating enzyme (AAE) consensus motif; other site 410289000383 active site 410289000384 AMP binding site [chemical binding]; other site 410289000385 CoA binding site [chemical binding]; other site 410289000386 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 410289000387 Condensation domain; Region: Condensation; pfam00668 410289000388 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 410289000389 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 410289000390 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 410289000391 acyl-activating enzyme (AAE) consensus motif; other site 410289000392 AMP binding site [chemical binding]; other site 410289000393 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 410289000394 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 410289000395 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 410289000396 putative NAD(P) binding site [chemical binding]; other site 410289000397 active site 410289000398 putative substrate binding site [chemical binding]; other site 410289000399 Predicted membrane protein [Function unknown]; Region: COG3336 410289000400 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 410289000401 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 410289000402 metal-binding site [ion binding] 410289000403 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 410289000404 Soluble P-type ATPase [General function prediction only]; Region: COG4087 410289000405 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 410289000406 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 410289000407 ligand binding site [chemical binding]; other site 410289000408 flexible hinge region; other site 410289000409 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 410289000410 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 410289000411 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 410289000412 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 410289000413 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 410289000414 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 410289000415 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 410289000416 motif II; other site 410289000417 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 410289000418 PE family; Region: PE; pfam00934 410289000419 Rhomboid family; Region: Rhomboid; pfam01694 410289000420 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 410289000421 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 410289000422 active site 410289000423 catalytic triad [active] 410289000424 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 410289000425 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 410289000426 NADP-binding site; other site 410289000427 homotetramer interface [polypeptide binding]; other site 410289000428 substrate binding site [chemical binding]; other site 410289000429 homodimer interface [polypeptide binding]; other site 410289000430 active site 410289000431 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 410289000432 dimer interface [polypeptide binding]; other site 410289000433 active site 410289000434 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 410289000435 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 410289000436 active site 410289000437 motif I; other site 410289000438 motif II; other site 410289000439 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 410289000440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 410289000441 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 410289000442 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 410289000443 Transcriptional regulator [Transcription]; Region: LysR; COG0583 410289000444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 410289000445 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 410289000446 dimerization interface [polypeptide binding]; other site 410289000447 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 410289000448 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 410289000449 PYR/PP interface [polypeptide binding]; other site 410289000450 dimer interface [polypeptide binding]; other site 410289000451 TPP binding site [chemical binding]; other site 410289000452 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 410289000453 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 410289000454 TPP-binding site; other site 410289000455 dimer interface [polypeptide binding]; other site 410289000456 acyl-CoA synthetase; Validated; Region: PRK05852 410289000457 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289000458 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 410289000459 acyl-activating enzyme (AAE) consensus motif; other site 410289000460 acyl-activating enzyme (AAE) consensus motif; other site 410289000461 putative AMP binding site [chemical binding]; other site 410289000462 putative active site [active] 410289000463 putative CoA binding site [chemical binding]; other site 410289000464 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 410289000465 elongation factor G; Reviewed; Region: PRK12740 410289000466 G1 box; other site 410289000467 putative GEF interaction site [polypeptide binding]; other site 410289000468 GTP/Mg2+ binding site [chemical binding]; other site 410289000469 Switch I region; other site 410289000470 G2 box; other site 410289000471 G3 box; other site 410289000472 Switch II region; other site 410289000473 G4 box; other site 410289000474 G5 box; other site 410289000475 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 410289000476 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 410289000477 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 410289000478 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 410289000479 PE family; Region: PE; pfam00934 410289000480 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 410289000481 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 410289000482 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 410289000483 trehalose synthase; Region: treS_nterm; TIGR02456 410289000484 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 410289000485 active site 410289000486 catalytic site [active] 410289000487 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 410289000488 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 410289000489 Predicted membrane protein [Function unknown]; Region: COG3619 410289000490 Predicted esterase [General function prediction only]; Region: COG0627 410289000491 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 410289000492 putative active site [active] 410289000493 putative catalytic site [active] 410289000494 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289000495 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289000496 active site 410289000497 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 410289000498 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 410289000499 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 410289000500 Coenzyme A binding pocket [chemical binding]; other site 410289000503 differs from Mb0139-3 by 1aa, G16R 410289000504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289000505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289000506 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289000507 Cytochrome P450; Region: p450; cl12078 410289000508 methionine sulfoxide reductase A; Provisional; Region: PRK14054 410289000509 SnoaL-like domain; Region: SnoaL_2; pfam12680 410289000510 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 410289000511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289000512 NAD(P) binding site [chemical binding]; other site 410289000513 active site 410289000514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 410289000515 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 410289000516 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 410289000517 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 410289000518 minor groove reading motif; other site 410289000519 helix-hairpin-helix signature motif; other site 410289000520 active site 410289000521 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 410289000522 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 410289000523 Cl- selectivity filter; other site 410289000524 Cl- binding residues [ion binding]; other site 410289000525 pore gating glutamate residue; other site 410289000526 dimer interface [polypeptide binding]; other site 410289000527 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289000528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289000529 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 410289000530 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 410289000531 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 410289000532 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 410289000533 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 410289000534 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 410289000535 NAD(P) binding site [chemical binding]; other site 410289000536 catalytic residues [active] 410289000537 short chain dehydrogenase; Provisional; Region: PRK07791 410289000538 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 410289000539 NAD binding site [chemical binding]; other site 410289000540 homodimer interface [polypeptide binding]; other site 410289000541 active site 410289000542 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 410289000543 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 410289000544 NAD(P) binding site [chemical binding]; other site 410289000545 PE family; Region: PE; pfam00934 410289000546 PE-PPE domain; Region: PE-PPE; pfam08237 410289000547 PE-PPE domain; Region: PE-PPE; pfam08237 410289000548 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 410289000549 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 410289000550 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 410289000551 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 410289000552 FAD binding site [chemical binding]; other site 410289000553 substrate binding site [chemical binding]; other site 410289000554 catalytic base [active] 410289000555 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 410289000556 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 410289000557 ligand binding site [chemical binding]; other site 410289000558 homodimer interface [polypeptide binding]; other site 410289000559 NAD(P) binding site [chemical binding]; other site 410289000560 trimer interface B [polypeptide binding]; other site 410289000561 trimer interface A [polypeptide binding]; other site 410289000562 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 410289000563 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 410289000564 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 410289000565 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 410289000566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289000567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289000568 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 410289000569 PE family; Region: PE; pfam00934 410289000570 PE-PPE domain; Region: PE-PPE; pfam08237 410289000571 PE family; Region: PE; pfam00934 410289000572 PE-PPE domain; Region: PE-PPE; pfam08237 410289000573 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 410289000574 FAD binding domain; Region: FAD_binding_4; pfam01565 410289000575 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 410289000576 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 410289000577 NAD(P) binding site [chemical binding]; other site 410289000578 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 410289000579 active site 410289000580 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 410289000581 putative hydrophobic ligand binding site [chemical binding]; other site 410289000582 Transcriptional regulators [Transcription]; Region: GntR; COG1802 410289000583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 410289000584 DNA-binding site [nucleotide binding]; DNA binding site 410289000585 FCD domain; Region: FCD; pfam07729 410289000586 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 410289000587 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289000588 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 410289000589 acyl-activating enzyme (AAE) consensus motif; other site 410289000590 acyl-activating enzyme (AAE) consensus motif; other site 410289000591 putative AMP binding site [chemical binding]; other site 410289000592 putative active site [active] 410289000593 putative CoA binding site [chemical binding]; other site 410289000594 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 410289000595 Permease; Region: Permease; pfam02405 410289000596 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 410289000597 Permease; Region: Permease; pfam02405 410289000598 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289000599 mce related protein; Region: MCE; pfam02470 410289000600 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 410289000601 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289000602 mce related protein; Region: MCE; pfam02470 410289000603 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 410289000604 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289000605 mce related protein; Region: MCE; pfam02470 410289000606 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289000607 mce related protein; Region: MCE; pfam02470 410289000608 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289000609 mce related protein; Region: MCE; pfam02470 410289000610 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289000611 mce related protein; Region: MCE; pfam02470 410289000612 RDD family; Region: RDD; pfam06271 410289000613 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 410289000614 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 410289000615 Predicted membrane protein [Function unknown]; Region: COG1511 410289000616 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 410289000617 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 410289000618 Pirin-related protein [General function prediction only]; Region: COG1741 410289000619 Pirin; Region: Pirin; pfam02678 410289000620 RNA polymerase factor sigma-70; Validated; Region: PRK08241 410289000621 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 410289000622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 410289000623 DNA binding residues [nucleotide binding] 410289000624 SnoaL-like domain; Region: SnoaL_2; pfam12680 410289000625 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 410289000626 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 410289000627 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 410289000628 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 410289000629 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 410289000630 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 410289000631 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 410289000632 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 410289000633 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 410289000634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289000635 S-adenosylmethionine binding site [chemical binding]; other site 410289000636 SPW repeat; Region: SPW; pfam03779 410289000637 SPW repeat; Region: SPW; pfam03779 410289000638 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 410289000639 6-phosphogluconate dehydratase; Region: edd; TIGR01196 410289000640 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 410289000641 putative homodimer interface [polypeptide binding]; other site 410289000642 putative homotetramer interface [polypeptide binding]; other site 410289000643 putative allosteric switch controlling residues; other site 410289000644 putative metal binding site [ion binding]; other site 410289000645 putative homodimer-homodimer interface [polypeptide binding]; other site 410289000646 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 410289000647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289000648 putative substrate translocation pore; other site 410289000649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 410289000650 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 410289000651 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 410289000652 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 410289000653 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 410289000654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289000655 Walker A/P-loop; other site 410289000656 ATP binding site [chemical binding]; other site 410289000657 Q-loop/lid; other site 410289000658 ABC transporter signature motif; other site 410289000659 Walker B; other site 410289000660 D-loop; other site 410289000661 H-loop/switch region; other site 410289000662 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 410289000663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289000664 Walker A/P-loop; other site 410289000665 ATP binding site [chemical binding]; other site 410289000666 Q-loop/lid; other site 410289000667 ABC transporter signature motif; other site 410289000668 Walker B; other site 410289000669 D-loop; other site 410289000670 H-loop/switch region; other site 410289000671 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 410289000672 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 410289000673 dimerization interface [polypeptide binding]; other site 410289000674 DNA binding residues [nucleotide binding] 410289000675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289000676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289000677 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 410289000678 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 410289000679 putative [Fe4-S4] binding site [ion binding]; other site 410289000680 putative molybdopterin cofactor binding site [chemical binding]; other site 410289000681 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 410289000682 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 410289000683 putative molybdopterin cofactor binding site; other site 410289000684 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 410289000685 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 410289000686 active site 410289000687 Zn binding site [ion binding]; other site 410289000688 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 410289000689 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 410289000690 Predicted integral membrane protein [Function unknown]; Region: COG0392 410289000691 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 410289000692 Domain of unknown function DUF20; Region: UPF0118; pfam01594 410289000693 MMPL family; Region: MMPL; pfam03176 410289000694 MMPL family; Region: MMPL; pfam03176 410289000695 LabA_like proteins; Region: LabA_like; cd06167 410289000696 putative metal binding site [ion binding]; other site 410289000697 Putative methyltransferase; Region: Methyltransf_4; pfam02390 410289000698 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 410289000699 active site 410289000700 substrate-binding site [chemical binding]; other site 410289000701 metal-binding site [ion binding] 410289000702 GTP binding site [chemical binding]; other site 410289000703 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 410289000704 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 410289000705 active site 410289000706 (T/H)XGH motif; other site 410289000707 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 410289000708 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 410289000709 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 410289000710 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 410289000711 FeS/SAM binding site; other site 410289000712 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 410289000713 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289000714 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 410289000715 acyl-activating enzyme (AAE) consensus motif; other site 410289000716 acyl-activating enzyme (AAE) consensus motif; other site 410289000717 putative AMP binding site [chemical binding]; other site 410289000718 putative active site [active] 410289000719 putative CoA binding site [chemical binding]; other site 410289000720 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289000721 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289000722 active site 410289000723 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 410289000724 putative active site [active] 410289000725 putative catalytic site [active] 410289000726 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 410289000727 active site 2 [active] 410289000728 active site 1 [active] 410289000729 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 410289000730 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 410289000731 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 410289000732 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 410289000733 Moco binding site; other site 410289000734 metal coordination site [ion binding]; other site 410289000735 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 410289000736 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 410289000737 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 410289000738 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 410289000739 NAD(P) binding site [chemical binding]; other site 410289000740 catalytic residues [active] 410289000741 RD10, 1902 bp. Region of Difference RD10, deleted region in Mycobacterium bovis BCG Pasteur (position 294686..294687) and Mycobacterium bovis AF2122/97 (position 264979..264980) compared to Mycobacterium tuberculosis H37Rv2 (position: 264755..266656, 1902bp). Removes gene Rv0222 and truncates genes Rv0221 and Rv0223 410289000742 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 410289000743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289000744 S-adenosylmethionine binding site [chemical binding]; other site 410289000745 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 410289000746 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 410289000747 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 410289000748 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 410289000749 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 410289000750 putative active site [active] 410289000751 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 410289000752 active site 410289000753 substrate binding pocket [chemical binding]; other site 410289000754 homodimer interaction site [polypeptide binding]; other site 410289000755 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289000756 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 410289000757 active site 410289000758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289000759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289000760 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 410289000761 active site 410289000762 diiron metal binding site [ion binding]; other site 410289000763 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 410289000764 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 410289000765 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 410289000766 NAD(P) binding site [chemical binding]; other site 410289000767 catalytic residues [active] 410289000768 Lipase maturation factor; Region: LMF1; pfam06762 410289000769 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 410289000770 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 410289000771 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 410289000772 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 410289000773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289000774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289000775 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 410289000776 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 410289000777 MaoC like domain; Region: MaoC_dehydratas; pfam01575 410289000778 active site 2 [active] 410289000779 active site 1 [active] 410289000780 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 410289000781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289000782 NAD(P) binding site [chemical binding]; other site 410289000783 active site 410289000784 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 410289000785 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 410289000786 dimer interface [polypeptide binding]; other site 410289000787 active site 410289000788 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 410289000789 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 410289000790 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 410289000791 FAD binding site [chemical binding]; other site 410289000792 substrate binding site [chemical binding]; other site 410289000793 catalytic residues [active] 410289000794 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 410289000795 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 410289000796 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 410289000797 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 410289000798 catalytic loop [active] 410289000799 iron binding site [ion binding]; other site 410289000800 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 410289000801 L-aspartate oxidase; Provisional; Region: PRK06175 410289000802 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 410289000803 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 410289000804 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 410289000805 putative dimer interface [polypeptide binding]; other site 410289000806 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 410289000807 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 410289000808 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 410289000809 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 410289000810 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 410289000811 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 410289000812 homotrimer interface [polypeptide binding]; other site 410289000813 Walker A motif; other site 410289000814 GTP binding site [chemical binding]; other site 410289000815 Walker B motif; other site 410289000816 cobyric acid synthase; Provisional; Region: PRK00784 410289000817 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 410289000818 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 410289000819 catalytic triad [active] 410289000820 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289000821 PPE family; Region: PPE; pfam00823 410289000822 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 410289000823 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 410289000824 putative active site [active] 410289000825 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 410289000826 putative active site [active] 410289000827 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 410289000828 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 410289000829 active site 410289000830 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 410289000831 DNA binding site [nucleotide binding] 410289000832 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 410289000833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 410289000834 Coenzyme A binding pocket [chemical binding]; other site 410289000835 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 410289000836 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 410289000837 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 410289000838 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 410289000839 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 410289000840 intersubunit interface [polypeptide binding]; other site 410289000841 5-oxoprolinase; Region: PLN02666 410289000842 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 410289000843 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 410289000844 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 410289000845 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 410289000846 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 410289000847 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 410289000848 nucleotide binding site [chemical binding]; other site 410289000849 acyl-CoA synthetase; Validated; Region: PRK07788 410289000850 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289000851 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289000852 active site 410289000853 CoA binding site [chemical binding]; other site 410289000854 AMP binding site [chemical binding]; other site 410289000855 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289000856 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289000857 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 410289000858 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289000859 FAD binding site [chemical binding]; other site 410289000860 substrate binding site [chemical binding]; other site 410289000861 catalytic base [active] 410289000862 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 410289000863 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289000864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289000865 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 410289000866 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 410289000867 Zn binding site [ion binding]; other site 410289000868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 410289000869 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 410289000870 putative active site [active] 410289000871 PE family; Region: PE; pfam00934 410289000872 I-RD01, 2924 bp. Region of Difference I-RDXXXX, inserted region in Mycobacterium bovis BCG Pasteur (position 362672..365595, 2924bp) and Mycobacterium bovis AF2122/97 (position 332966..335745, 2780 bp) compared to Mycobacterium tuberculosis H37Rv2 (position: 334641..334642). Duplicates PE_PGRS3 410289000873 PE family; Region: PE; pfam00934 410289000874 PE family; Region: PE; pfam00934 410289000875 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289000876 PPE family; Region: PPE; pfam00823 410289000877 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289000878 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 410289000879 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 410289000880 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 410289000881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289000882 Walker A motif; other site 410289000883 ATP binding site [chemical binding]; other site 410289000884 Walker B motif; other site 410289000885 arginine finger; other site 410289000886 Protein of unknown function (DUF690); Region: DUF690; pfam05108 410289000887 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 410289000888 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 410289000889 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 410289000890 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 410289000891 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 410289000892 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289000893 PPE family; Region: PPE; pfam00823 410289000894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 410289000895 EspG family; Region: ESX-1_EspG; pfam14011 410289000896 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 410289000897 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 410289000898 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 410289000899 active site 410289000900 catalytic residues [active] 410289000901 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 410289000902 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 410289000903 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 410289000904 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 410289000905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289000906 S-adenosylmethionine binding site [chemical binding]; other site 410289000907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 410289000908 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 410289000909 Sulfatase; Region: Sulfatase; cl17466 410289000910 hypothetical protein; Region: PHA01748 410289000911 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 410289000912 putative active site [active] 410289000913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289000914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289000915 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 410289000916 protochlorophyllide reductase; Region: PLN00015 410289000917 putative NAD(P) binding site [chemical binding]; other site 410289000918 active site 410289000919 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289000920 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289000921 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289000922 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289000923 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289000924 PPE family; Region: PPE; pfam00823 410289000925 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289000926 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289000927 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289000928 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289000929 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289000930 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289000931 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289000932 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289000933 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289000934 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289000935 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 410289000936 putative FMN binding site [chemical binding]; other site 410289000937 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 410289000938 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 410289000939 active site 410289000940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 410289000941 SnoaL-like domain; Region: SnoaL_4; pfam13577 410289000942 SnoaL-like domain; Region: SnoaL_3; pfam13474 410289000943 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 410289000944 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 410289000945 nucleotide binding site [chemical binding]; other site 410289000946 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 410289000947 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 410289000948 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 410289000949 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 410289000950 active site 410289000951 catalytic residues [active] 410289000952 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 410289000953 Muconolactone delta-isomerase; Region: MIase; cl01992 410289000954 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 410289000955 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 410289000956 putative active site [active] 410289000957 catalytic site [active] 410289000958 putative metal binding site [ion binding]; other site 410289000959 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 410289000960 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 410289000961 putative substrate binding pocket [chemical binding]; other site 410289000962 AC domain interface; other site 410289000963 catalytic triad [active] 410289000964 AB domain interface; other site 410289000965 interchain disulfide; other site 410289000966 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 410289000967 trimer interface [polypeptide binding]; other site 410289000968 active site 410289000969 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 410289000970 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 410289000971 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 410289000972 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 410289000973 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 410289000974 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 410289000975 dimerization interface [polypeptide binding]; other site 410289000976 putative DNA binding site [nucleotide binding]; other site 410289000977 putative Zn2+ binding site [ion binding]; other site 410289000978 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 410289000979 active site residue [active] 410289000980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289000981 S-adenosylmethionine binding site [chemical binding]; other site 410289000982 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289000983 Cytochrome P450; Region: p450; cl12078 410289000984 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 410289000985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289000986 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 410289000987 Methyltransferase domain; Region: Methyltransf_23; pfam13489 410289000988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289000989 S-adenosylmethionine binding site [chemical binding]; other site 410289000990 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289000991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289000992 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 410289000993 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 410289000994 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 410289000995 SnoaL-like domain; Region: SnoaL_2; pfam12680 410289000996 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 410289000997 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 410289000998 substrate binding site; other site 410289000999 tetramer interface; other site 410289001000 PE family; Region: PE; pfam00934 410289001001 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289001002 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289001003 active site 410289001004 aminotransferase AlaT; Validated; Region: PRK09265 410289001005 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 410289001006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289001007 homodimer interface [polypeptide binding]; other site 410289001008 catalytic residue [active] 410289001009 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 410289001010 4Fe-4S binding domain; Region: Fer4; pfam00037 410289001011 Cysteine-rich domain; Region: CCG; pfam02754 410289001012 Cysteine-rich domain; Region: CCG; pfam02754 410289001013 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 410289001014 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 410289001015 DNA binding residues [nucleotide binding] 410289001016 dimerization interface [polypeptide binding]; other site 410289001017 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 410289001018 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 410289001019 G3 box; other site 410289001020 Switch II region; other site 410289001021 GTP/Mg2+ binding site [chemical binding]; other site 410289001022 G4 box; other site 410289001023 G5 box; other site 410289001024 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 410289001025 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 410289001026 G1 box; other site 410289001027 GTP/Mg2+ binding site [chemical binding]; other site 410289001028 G2 box; other site 410289001029 Switch I region; other site 410289001030 G3 box; other site 410289001031 Switch II region; other site 410289001032 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 410289001033 active site 410289001034 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 410289001035 TIGR04255 family protein; Region: sporadTIGR04255 410289001036 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 410289001037 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 410289001038 nucleotide binding site [chemical binding]; other site 410289001039 NEF interaction site [polypeptide binding]; other site 410289001040 SBD interface [polypeptide binding]; other site 410289001041 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 410289001042 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 410289001043 dimer interface [polypeptide binding]; other site 410289001044 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 410289001045 chaperone protein DnaJ; Provisional; Region: PRK14279 410289001046 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 410289001047 HSP70 interaction site [polypeptide binding]; other site 410289001048 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 410289001049 Zn binding sites [ion binding]; other site 410289001050 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 410289001051 dimer interface [polypeptide binding]; other site 410289001052 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 410289001053 DNA binding residues [nucleotide binding] 410289001054 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 410289001055 putative dimer interface [polypeptide binding]; other site 410289001056 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289001057 PPE family; Region: PPE; pfam00823 410289001058 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289001059 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289001060 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289001061 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289001062 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289001063 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289001064 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289001065 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289001066 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289001067 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 410289001068 CoenzymeA binding site [chemical binding]; other site 410289001069 subunit interaction site [polypeptide binding]; other site 410289001070 PHB binding site; other site 410289001071 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 410289001072 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 410289001073 GDP-binding site [chemical binding]; other site 410289001074 ACT binding site; other site 410289001075 IMP binding site; other site 410289001076 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 410289001077 Peptidase family M50; Region: Peptidase_M50; pfam02163 410289001078 active site 410289001079 putative substrate binding region [chemical binding]; other site 410289001080 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 410289001081 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 410289001082 MgtE intracellular N domain; Region: MgtE_N; pfam03448 410289001083 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 410289001084 Divalent cation transporter; Region: MgtE; pfam01769 410289001085 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 410289001086 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 410289001087 active site 410289001088 intersubunit interface [polypeptide binding]; other site 410289001089 zinc binding site [ion binding]; other site 410289001090 Na+ binding site [ion binding]; other site 410289001091 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 410289001092 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 410289001093 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 410289001094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 410289001095 AAA domain; Region: AAA_33; pfam13671 410289001096 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 410289001097 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 410289001098 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 410289001099 metal ion-dependent adhesion site (MIDAS); other site 410289001100 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 410289001101 putative hydrophobic ligand binding site [chemical binding]; other site 410289001102 MoxR-like ATPases [General function prediction only]; Region: COG0714 410289001103 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 410289001104 Ligand binding site; other site 410289001105 metal-binding site 410289001106 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 410289001107 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 410289001108 XdhC Rossmann domain; Region: XdhC_C; pfam13478 410289001109 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 410289001110 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 410289001111 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 410289001112 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 410289001113 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 410289001114 catalytic loop [active] 410289001115 iron binding site [ion binding]; other site 410289001116 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 410289001117 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 410289001118 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 410289001119 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 410289001120 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 410289001121 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 410289001122 XdhC Rossmann domain; Region: XdhC_C; pfam13478 410289001123 Transcriptional regulator [Transcription]; Region: LysR; COG0583 410289001124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 410289001125 LysR substrate binding domain; Region: LysR_substrate; pfam03466 410289001126 dimerization interface [polypeptide binding]; other site 410289001127 Uncharacterized conserved protein [Function unknown]; Region: COG3360 410289001128 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 410289001129 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 410289001130 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 410289001131 active site 410289001132 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 410289001133 Clp amino terminal domain; Region: Clp_N; pfam02861 410289001134 Clp amino terminal domain; Region: Clp_N; pfam02861 410289001135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289001136 Walker A motif; other site 410289001137 ATP binding site [chemical binding]; other site 410289001138 Walker B motif; other site 410289001139 arginine finger; other site 410289001140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289001141 Walker A motif; other site 410289001142 ATP binding site [chemical binding]; other site 410289001143 Walker B motif; other site 410289001144 arginine finger; other site 410289001145 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 410289001146 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 410289001147 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 410289001148 heme-binding site [chemical binding]; other site 410289001149 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 410289001150 FAD binding pocket [chemical binding]; other site 410289001151 FAD binding motif [chemical binding]; other site 410289001152 phosphate binding motif [ion binding]; other site 410289001153 beta-alpha-beta structure motif; other site 410289001154 NAD binding pocket [chemical binding]; other site 410289001155 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 410289001156 cyclase homology domain; Region: CHD; cd07302 410289001157 nucleotidyl binding site; other site 410289001158 metal binding site [ion binding]; metal-binding site 410289001159 dimer interface [polypeptide binding]; other site 410289001160 Predicted ATPase [General function prediction only]; Region: COG3903 410289001161 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 410289001162 Walker A motif; other site 410289001163 ATP binding site [chemical binding]; other site 410289001164 Walker B motif; other site 410289001165 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 410289001166 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 410289001167 DNA binding residues [nucleotide binding] 410289001168 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289001169 PPE family; Region: PPE; pfam00823 410289001170 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 410289001171 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 410289001172 ATP-grasp domain; Region: ATP-grasp_4; cl17255 410289001173 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 410289001174 active site residue [active] 410289001175 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 410289001176 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 410289001177 homodimer interface [polypeptide binding]; other site 410289001178 substrate-cofactor binding pocket; other site 410289001179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289001180 catalytic residue [active] 410289001181 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 410289001182 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 410289001183 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 410289001184 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289001185 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289001186 active site 410289001187 PLD-like domain; Region: PLDc_2; pfam13091 410289001188 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 410289001189 Beta-lactamase; Region: Beta-lactamase; pfam00144 410289001190 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 410289001191 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289001192 FAD binding site [chemical binding]; other site 410289001193 substrate binding pocket [chemical binding]; other site 410289001194 catalytic base [active] 410289001195 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 410289001196 MMPL family; Region: MMPL; pfam03176 410289001197 MMPL family; Region: MMPL; pfam03176 410289001198 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 410289001199 acyl-CoA synthetase; Validated; Region: PRK05850 410289001200 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 410289001201 acyl-activating enzyme (AAE) consensus motif; other site 410289001202 active site 410289001203 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 410289001204 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 410289001205 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289001206 active site 410289001207 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 410289001208 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 410289001209 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 410289001210 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289001211 Thioesterase; Region: PKS_TE; smart00824 410289001212 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 410289001213 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 410289001214 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 410289001215 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 410289001216 phosphate acetyltransferase; Reviewed; Region: PRK05632 410289001217 DRTGG domain; Region: DRTGG; pfam07085 410289001218 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 410289001219 propionate/acetate kinase; Provisional; Region: PRK12379 410289001220 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 410289001221 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 410289001222 Catalytic domain of Protein Kinases; Region: PKc; cd00180 410289001223 active site 410289001224 ATP binding site [chemical binding]; other site 410289001225 substrate binding site [chemical binding]; other site 410289001226 activation loop (A-loop); other site 410289001227 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 410289001228 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 410289001229 substrate binding pocket [chemical binding]; other site 410289001230 membrane-bound complex binding site; other site 410289001231 hinge residues; other site 410289001232 NUDIX domain; Region: NUDIX; pfam00293 410289001233 nudix motif; other site 410289001234 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 410289001235 thiamine phosphate binding site [chemical binding]; other site 410289001236 active site 410289001237 pyrophosphate binding site [ion binding]; other site 410289001238 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 410289001239 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 410289001240 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 410289001241 thiS-thiF/thiG interaction site; other site 410289001242 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 410289001243 ThiS interaction site; other site 410289001244 putative active site [active] 410289001245 tetramer interface [polypeptide binding]; other site 410289001246 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 410289001247 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 410289001248 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 410289001249 PA/protease or protease-like domain interface [polypeptide binding]; other site 410289001250 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 410289001251 active site 410289001252 metal binding site [ion binding]; metal-binding site 410289001253 Predicted metalloprotease [General function prediction only]; Region: COG2321 410289001254 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 410289001255 Zn binding site [ion binding]; other site 410289001256 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 410289001257 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 410289001258 dimer interface [polypeptide binding]; other site 410289001259 substrate binding site [chemical binding]; other site 410289001260 ATP binding site [chemical binding]; other site 410289001261 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 410289001262 ThiC-associated domain; Region: ThiC-associated; pfam13667 410289001263 ThiC family; Region: ThiC; pfam01964 410289001264 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 410289001265 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 410289001266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 410289001267 motif II; other site 410289001268 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 410289001269 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 410289001270 putative catalytic site [active] 410289001271 putative phosphate binding site [ion binding]; other site 410289001272 active site 410289001273 metal binding site A [ion binding]; metal-binding site 410289001274 DNA binding site [nucleotide binding] 410289001275 putative AP binding site [nucleotide binding]; other site 410289001276 putative metal binding site B [ion binding]; other site 410289001277 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 410289001278 active site 410289001279 catalytic residues [active] 410289001280 metal binding site [ion binding]; metal-binding site 410289001281 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 410289001282 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 410289001283 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 410289001284 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 410289001285 E-class dimer interface [polypeptide binding]; other site 410289001286 P-class dimer interface [polypeptide binding]; other site 410289001287 active site 410289001288 Cu2+ binding site [ion binding]; other site 410289001289 Zn2+ binding site [ion binding]; other site 410289001290 carboxylate-amine ligase; Provisional; Region: PRK13517 410289001291 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 410289001292 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 410289001293 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 410289001294 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 410289001295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289001296 Walker A motif; other site 410289001297 ATP binding site [chemical binding]; other site 410289001298 Walker B motif; other site 410289001299 arginine finger; other site 410289001300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289001301 Walker A motif; other site 410289001302 ATP binding site [chemical binding]; other site 410289001303 Walker B motif; other site 410289001304 arginine finger; other site 410289001305 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 410289001306 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 410289001307 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 410289001308 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 410289001309 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 410289001310 dimer interface [polypeptide binding]; other site 410289001311 putative functional site; other site 410289001312 putative MPT binding site; other site 410289001313 short chain dehydrogenase; Provisional; Region: PRK06197 410289001314 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 410289001315 putative NAD(P) binding site [chemical binding]; other site 410289001316 active site 410289001317 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 410289001318 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 410289001319 ring oligomerisation interface [polypeptide binding]; other site 410289001320 ATP/Mg binding site [chemical binding]; other site 410289001321 stacking interactions; other site 410289001322 hinge regions; other site 410289001323 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289001324 PPE family; Region: PPE; pfam00823 410289001325 Protein of unknown function (DUF664); Region: DUF664; pfam04978 410289001326 DinB superfamily; Region: DinB_2; pfam12867 410289001327 putative anti-sigmaE protein; Provisional; Region: PRK13920 410289001328 Anti-sigma-K factor rskA; Region: RskA; pfam10099 410289001329 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 410289001330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 410289001331 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 410289001332 DNA binding residues [nucleotide binding] 410289001333 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 410289001334 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 410289001335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289001336 S-adenosylmethionine binding site [chemical binding]; other site 410289001337 Uncharacterized conserved protein [Function unknown]; Region: COG3496 410289001338 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 410289001339 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 410289001340 dimer interface [polypeptide binding]; other site 410289001341 Transport protein; Region: actII; TIGR00833 410289001342 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 410289001343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289001344 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289001345 PPE family; Region: PPE; pfam00823 410289001346 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289001347 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 410289001348 enoyl-CoA hydratase; Provisional; Region: PRK12478 410289001349 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289001350 substrate binding site [chemical binding]; other site 410289001351 oxyanion hole (OAH) forming residues; other site 410289001352 trimer interface [polypeptide binding]; other site 410289001353 PemK-like protein; Region: PemK; pfam02452 410289001354 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 410289001355 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 410289001356 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 410289001357 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 410289001358 NAD(P) binding site [chemical binding]; other site 410289001359 catalytic residues [active] 410289001360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 410289001361 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 410289001362 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 410289001363 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 410289001364 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 410289001365 Uncharacterized conserved protein [Function unknown]; Region: COG2128 410289001366 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 410289001367 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 410289001368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 410289001369 non-specific DNA binding site [nucleotide binding]; other site 410289001370 salt bridge; other site 410289001371 sequence-specific DNA binding site [nucleotide binding]; other site 410289001372 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 410289001373 Domain of unknown function (DUF955); Region: DUF955; pfam06114 410289001374 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 410289001375 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 410289001376 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 410289001377 active site 410289001378 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 410289001379 active site 2 [active] 410289001380 isocitrate lyase; Provisional; Region: PRK15063 410289001381 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 410289001382 oligomerization interface [polypeptide binding]; other site 410289001383 active site 410289001384 metal binding site [ion binding]; metal-binding site 410289001385 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 410289001386 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 410289001387 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 410289001388 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 410289001389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289001390 S-adenosylmethionine binding site [chemical binding]; other site 410289001391 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 410289001392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 410289001393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289001394 S-adenosylmethionine binding site [chemical binding]; other site 410289001395 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 410289001396 UbiA prenyltransferase family; Region: UbiA; pfam01040 410289001397 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289001398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289001399 Predicted membrane protein [Function unknown]; Region: COG2733 410289001400 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 410289001401 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 410289001402 non-specific DNA binding site [nucleotide binding]; other site 410289001403 salt bridge; other site 410289001404 sequence-specific DNA binding site [nucleotide binding]; other site 410289001405 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 410289001406 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 410289001407 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 410289001408 intersubunit interface [polypeptide binding]; other site 410289001409 active site 410289001410 catalytic residue [active] 410289001411 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 410289001412 Predicted amidohydrolase [General function prediction only]; Region: COG0388 410289001413 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 410289001414 putative active site [active] 410289001415 catalytic triad [active] 410289001416 putative dimer interface [polypeptide binding]; other site 410289001417 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 410289001418 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 410289001419 FAD binding domain; Region: FAD_binding_4; pfam01565 410289001420 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 410289001421 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 410289001422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 410289001423 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 410289001424 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 410289001425 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 410289001426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289001427 NAD(P) binding site [chemical binding]; other site 410289001428 active site 410289001429 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 410289001430 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 410289001431 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 410289001432 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 410289001433 putative ADP-binding pocket [chemical binding]; other site 410289001434 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 410289001435 L-lysine exporter; Region: 2a75; TIGR00948 410289001436 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 410289001437 catalytic core [active] 410289001438 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 410289001439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 410289001440 dimer interface [polypeptide binding]; other site 410289001441 phosphorylation site [posttranslational modification] 410289001442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 410289001443 ATP binding site [chemical binding]; other site 410289001444 Mg2+ binding site [ion binding]; other site 410289001445 G-X-G motif; other site 410289001446 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 410289001447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 410289001448 active site 410289001449 phosphorylation site [posttranslational modification] 410289001450 intermolecular recognition site; other site 410289001451 dimerization interface [polypeptide binding]; other site 410289001452 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 410289001453 DNA binding site [nucleotide binding] 410289001454 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 410289001455 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 410289001456 Transcriptional regulators [Transcription]; Region: FadR; COG2186 410289001457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 410289001458 DNA-binding site [nucleotide binding]; DNA binding site 410289001459 FCD domain; Region: FCD; pfam07729 410289001460 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 410289001461 exopolyphosphatase; Region: exo_poly_only; TIGR03706 410289001462 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 410289001463 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 410289001464 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 410289001465 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 410289001466 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 410289001467 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 410289001468 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 410289001469 DNA binding domain, excisionase family; Region: excise; TIGR01764 410289001470 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 410289001471 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 410289001472 putative NAD(P) binding site [chemical binding]; other site 410289001473 active site 410289001474 putative substrate binding site [chemical binding]; other site 410289001475 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 410289001476 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 410289001477 putative acyl-acceptor binding pocket; other site 410289001478 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 410289001479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 410289001480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289001481 S-adenosylmethionine binding site [chemical binding]; other site 410289001482 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 410289001483 active site 410289001484 catalytic site [active] 410289001485 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 410289001486 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 410289001487 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 410289001488 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 410289001489 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 410289001490 glutamyl-tRNA reductase; Region: hemA; TIGR01035 410289001491 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 410289001492 tRNA; other site 410289001493 putative tRNA binding site [nucleotide binding]; other site 410289001494 putative NADP binding site [chemical binding]; other site 410289001495 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 410289001496 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 410289001497 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 410289001498 domain interfaces; other site 410289001499 active site 410289001500 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 410289001501 active site 410289001502 homodimer interface [polypeptide binding]; other site 410289001503 SAM binding site [chemical binding]; other site 410289001504 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 410289001505 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 410289001506 active site 410289001507 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 410289001508 dimer interface [polypeptide binding]; other site 410289001509 active site 410289001510 Schiff base residues; other site 410289001511 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289001512 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289001513 active site 410289001514 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 410289001515 anti sigma factor interaction site; other site 410289001516 regulatory phosphorylation site [posttranslational modification]; other site 410289001517 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 410289001518 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 410289001519 active site 410289001520 catalytic triad [active] 410289001521 oxyanion hole [active] 410289001522 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 410289001523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289001524 Methyltransferase domain; Region: Methyltransf_31; pfam13847 410289001525 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 410289001526 Domain of unknown function (DUF385); Region: DUF385; pfam04075 410289001527 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 410289001528 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 410289001529 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 410289001530 catalytic residue [active] 410289001531 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 410289001532 catalytic core [active] 410289001533 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 410289001534 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 410289001535 catalytic residues [active] 410289001536 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 410289001537 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 410289001538 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 410289001539 ResB-like family; Region: ResB; pfam05140 410289001540 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 410289001541 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 410289001542 AAA domain; Region: AAA_31; pfam13614 410289001543 P-loop; other site 410289001544 Magnesium ion binding site [ion binding]; other site 410289001545 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 410289001546 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 410289001547 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 410289001548 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 410289001549 dimer interface [polypeptide binding]; other site 410289001550 active site 410289001551 CoA binding pocket [chemical binding]; other site 410289001552 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 410289001553 UbiA prenyltransferase family; Region: UbiA; pfam01040 410289001554 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 410289001555 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 410289001556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289001557 NAD(P) binding site [chemical binding]; other site 410289001558 active site 410289001559 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 410289001560 Ligand binding site; other site 410289001561 Putative Catalytic site; other site 410289001562 DXD motif; other site 410289001563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 410289001564 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 410289001565 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289001566 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289001567 acyl-activating enzyme (AAE) consensus motif; other site 410289001568 acyl-activating enzyme (AAE) consensus motif; other site 410289001569 AMP binding site [chemical binding]; other site 410289001570 active site 410289001571 CoA binding site [chemical binding]; other site 410289001572 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 410289001573 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 410289001574 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 410289001575 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 410289001576 active site 410289001577 short chain dehydrogenase; Provisional; Region: PRK05866 410289001578 classical (c) SDRs; Region: SDR_c; cd05233 410289001579 NAD(P) binding site [chemical binding]; other site 410289001580 active site 410289001581 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289001582 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 410289001583 substrate binding site [chemical binding]; other site 410289001584 oxyanion hole (OAH) forming residues; other site 410289001585 trimer interface [polypeptide binding]; other site 410289001586 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 410289001587 putative active site [active] 410289001588 homotetrameric interface [polypeptide binding]; other site 410289001589 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 410289001590 acyl-CoA synthetase; Validated; Region: PRK06188 410289001591 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 410289001592 putative active site [active] 410289001593 putative CoA binding site [chemical binding]; other site 410289001594 putative AMP binding site [chemical binding]; other site 410289001595 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 410289001596 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 410289001597 active site 410289001598 O-succinylbenzoate synthase; Provisional; Region: PRK02901 410289001599 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 410289001600 active site 410289001601 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 410289001602 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 410289001603 TAP-like protein; Region: Abhydrolase_4; pfam08386 410289001604 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 410289001605 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 410289001606 dimer interface [polypeptide binding]; other site 410289001607 tetramer interface [polypeptide binding]; other site 410289001608 PYR/PP interface [polypeptide binding]; other site 410289001609 TPP binding site [chemical binding]; other site 410289001610 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 410289001611 TPP-binding site; other site 410289001612 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 410289001613 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 410289001614 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 410289001615 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 410289001616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289001617 S-adenosylmethionine binding site [chemical binding]; other site 410289001618 Protein of unknown function (DUF732); Region: DUF732; pfam05305 410289001619 Methyltransferase domain; Region: Methyltransf_23; pfam13489 410289001620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289001621 S-adenosylmethionine binding site [chemical binding]; other site 410289001622 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 410289001623 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 410289001624 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 410289001625 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 410289001626 substrate binding pocket [chemical binding]; other site 410289001627 chain length determination region; other site 410289001628 substrate-Mg2+ binding site; other site 410289001629 catalytic residues [active] 410289001630 aspartate-rich region 1; other site 410289001631 active site lid residues [active] 410289001632 aspartate-rich region 2; other site 410289001633 heat shock protein HtpX; Provisional; Region: PRK03072 410289001634 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 410289001635 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 410289001636 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 410289001637 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 410289001638 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 410289001639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 410289001640 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 410289001641 O-methyltransferase; Region: Methyltransf_2; pfam00891 410289001642 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289001643 Cytochrome P450; Region: p450; cl12078 410289001644 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 410289001645 ATP cone domain; Region: ATP-cone; pfam03477 410289001646 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 410289001647 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 410289001648 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 410289001649 active site 410289001650 dimer interface [polypeptide binding]; other site 410289001651 effector binding site; other site 410289001652 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 410289001653 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 410289001654 active site 410289001655 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 410289001656 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 410289001657 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 410289001658 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 410289001659 active site 410289001660 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 410289001661 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 410289001662 putative active site [active] 410289001663 putative metal binding site [ion binding]; other site 410289001664 hypothetical protein; Provisional; Region: PRK07588 410289001665 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 410289001666 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 410289001667 dimerization interface [polypeptide binding]; other site 410289001668 putative DNA binding site [nucleotide binding]; other site 410289001669 putative Zn2+ binding site [ion binding]; other site 410289001670 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 410289001671 putative hydrophobic ligand binding site [chemical binding]; other site 410289001672 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 410289001673 TIGR03086 family protein; Region: TIGR03086 410289001674 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 410289001675 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 410289001676 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 410289001677 PE family; Region: PE; pfam00934 410289001678 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 410289001679 Uncharacterized conserved protein [Function unknown]; Region: COG1656 410289001680 Protein of unknown function DUF82; Region: DUF82; pfam01927 410289001681 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 410289001682 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 410289001683 putative active site [active] 410289001684 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 410289001685 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 410289001686 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 410289001687 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 410289001688 Transcriptional regulators [Transcription]; Region: FadR; COG2186 410289001689 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 410289001690 DNA-binding site [nucleotide binding]; DNA binding site 410289001691 FCD domain; Region: FCD; pfam07729 410289001692 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 410289001693 Permease; Region: Permease; pfam02405 410289001694 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 410289001695 Permease; Region: Permease; pfam02405 410289001696 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289001697 mce related protein; Region: MCE; pfam02470 410289001698 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 410289001699 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 410289001700 mce related protein; Region: MCE; pfam02470 410289001701 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 410289001702 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289001703 mce related protein; Region: MCE; pfam02470 410289001704 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289001705 mce related protein; Region: MCE; pfam02470 410289001706 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 410289001707 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289001708 mce related protein; Region: MCE; pfam02470 410289001709 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289001710 mce related protein; Region: MCE; pfam02470 410289001711 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 410289001712 oligomeric interface; other site 410289001713 putative active site [active] 410289001714 homodimer interface [polypeptide binding]; other site 410289001715 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 410289001716 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 410289001717 AAA domain; Region: AAA_14; pfam13173 410289001718 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 410289001719 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 410289001720 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 410289001721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 410289001722 ATP binding site [chemical binding]; other site 410289001723 Mg2+ binding site [ion binding]; other site 410289001724 G-X-G motif; other site 410289001725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 410289001726 dimerization interface [polypeptide binding]; other site 410289001727 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 410289001728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 410289001729 active site 410289001730 phosphorylation site [posttranslational modification] 410289001731 intermolecular recognition site; other site 410289001732 dimerization interface [polypeptide binding]; other site 410289001733 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 410289001734 DNA binding site [nucleotide binding] 410289001735 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 410289001736 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 410289001737 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 410289001738 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 410289001739 catalytic residues [active] 410289001740 catalytic nucleophile [active] 410289001741 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 410289001742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 410289001743 Probable transposase; Region: OrfB_IS605; pfam01385 410289001744 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 410289001745 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 410289001746 putative active site [active] 410289001747 SEC-C motif; Region: SEC-C; pfam02810 410289001748 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 410289001749 putative active site [active] 410289001750 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 410289001751 dimer interface [polypeptide binding]; other site 410289001752 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 410289001753 active site 410289001754 galactokinase; Provisional; Region: PRK00555 410289001755 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 410289001756 Protein of unknown function (DUF732); Region: DUF732; pfam05305 410289001757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 410289001758 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 410289001759 putative active site [active] 410289001760 Uncharacterized conserved protein [Function unknown]; Region: COG0398 410289001761 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 410289001762 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 410289001763 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 410289001764 oligomeric interface; other site 410289001765 putative active site [active] 410289001766 homodimer interface [polypeptide binding]; other site 410289001767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 410289001768 FIST N domain; Region: FIST; pfam08495 410289001769 FIST C domain; Region: FIST_C; pfam10442 410289001770 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 410289001771 AAA domain; Region: AAA_30; pfam13604 410289001772 Family description; Region: UvrD_C_2; pfam13538 410289001773 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 410289001774 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 410289001775 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 410289001776 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 410289001777 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 410289001778 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289001779 substrate binding site [chemical binding]; other site 410289001780 oxyanion hole (OAH) forming residues; other site 410289001781 trimer interface [polypeptide binding]; other site 410289001782 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 410289001783 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 410289001784 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 410289001785 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 410289001786 active site 410289001787 catalytic site [active] 410289001788 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 410289001789 active site 410289001790 catalytic site [active] 410289001791 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 410289001792 active site 410289001793 catalytic site [active] 410289001794 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 410289001795 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 410289001796 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 410289001797 putative homodimer interface [polypeptide binding]; other site 410289001798 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 410289001799 heterodimer interface [polypeptide binding]; other site 410289001800 homodimer interface [polypeptide binding]; other site 410289001801 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 410289001802 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 410289001803 23S rRNA interface [nucleotide binding]; other site 410289001804 L7/L12 interface [polypeptide binding]; other site 410289001805 putative thiostrepton binding site; other site 410289001806 L25 interface [polypeptide binding]; other site 410289001807 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 410289001808 mRNA/rRNA interface [nucleotide binding]; other site 410289001809 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 410289001810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289001811 S-adenosylmethionine binding site [chemical binding]; other site 410289001812 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 410289001813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 410289001814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289001815 S-adenosylmethionine binding site [chemical binding]; other site 410289001816 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 410289001817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 410289001818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289001819 S-adenosylmethionine binding site [chemical binding]; other site 410289001820 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 410289001821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 410289001822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289001823 S-adenosylmethionine binding site [chemical binding]; other site 410289001824 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 410289001825 TAP-like protein; Region: Abhydrolase_4; pfam08386 410289001826 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 410289001827 ABC1 family; Region: ABC1; cl17513 410289001828 RvD6, 533 bp. Region of Difference RvD6, inserted region in Mycobacterium bovis BCG Pasteur (position 773511..774043, 533bp) and Mycobacterium bovis AF2122/97 (position 743871..744403, 533bp) compared to Mycobacterium tuberculosis H37Rv2 (position: 742634..742635) where this sequence has been deleted. Also present in Mycobacterium tuberculosis CDC1551. Leads to BCG_0697 being longer at N-terminus than Rv0648 by 183 aa 410289001829 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 410289001830 active site 410289001831 catalytic site [active] 410289001832 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 410289001833 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 410289001834 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 410289001835 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 410289001836 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 410289001837 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 410289001838 23S rRNA interface [nucleotide binding]; other site 410289001839 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 410289001840 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 410289001841 core dimer interface [polypeptide binding]; other site 410289001842 peripheral dimer interface [polypeptide binding]; other site 410289001843 L10 interface [polypeptide binding]; other site 410289001844 L11 interface [polypeptide binding]; other site 410289001845 putative EF-Tu interaction site [polypeptide binding]; other site 410289001846 putative EF-G interaction site [polypeptide binding]; other site 410289001847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289001848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289001849 WHG domain; Region: WHG; pfam13305 410289001850 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 410289001851 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 410289001852 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 410289001853 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 410289001854 Walker A/P-loop; other site 410289001855 ATP binding site [chemical binding]; other site 410289001856 Q-loop/lid; other site 410289001857 ABC transporter signature motif; other site 410289001858 Walker B; other site 410289001859 D-loop; other site 410289001860 H-loop/switch region; other site 410289001861 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 410289001862 putative active site [active] 410289001863 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 410289001864 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 410289001865 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 410289001866 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 410289001867 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 410289001868 Sulfatase; Region: Sulfatase; pfam00884 410289001869 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 410289001870 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 410289001871 putative active site [active] 410289001872 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 410289001873 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 410289001874 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 410289001875 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 410289001876 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 410289001877 RPB10 interaction site [polypeptide binding]; other site 410289001878 RPB1 interaction site [polypeptide binding]; other site 410289001879 RPB11 interaction site [polypeptide binding]; other site 410289001880 RPB3 interaction site [polypeptide binding]; other site 410289001881 RPB12 interaction site [polypeptide binding]; other site 410289001882 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 410289001883 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 410289001884 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 410289001885 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 410289001886 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 410289001887 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 410289001888 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 410289001889 G-loop; other site 410289001890 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 410289001891 DNA binding site [nucleotide binding] 410289001892 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 410289001893 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 410289001894 endonuclease IV; Provisional; Region: PRK01060 410289001895 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 410289001896 AP (apurinic/apyrimidinic) site pocket; other site 410289001897 DNA interaction; other site 410289001898 Metal-binding active site; metal-binding site 410289001899 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 410289001900 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 410289001901 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 410289001902 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289001903 active site 410289001904 enoyl-CoA hydratase; Provisional; Region: PRK12478 410289001905 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289001906 substrate binding site [chemical binding]; other site 410289001907 oxyanion hole (OAH) forming residues; other site 410289001908 trimer interface [polypeptide binding]; other site 410289001909 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 410289001910 PaaX-like protein; Region: PaaX; pfam07848 410289001911 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 410289001912 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 410289001913 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289001914 substrate binding site [chemical binding]; other site 410289001915 oxyanion hole (OAH) forming residues; other site 410289001916 trimer interface [polypeptide binding]; other site 410289001917 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 410289001918 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 410289001919 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 410289001920 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 410289001921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289001922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289001923 WHG domain; Region: WHG; pfam13305 410289001924 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 410289001925 S17 interaction site [polypeptide binding]; other site 410289001926 S8 interaction site; other site 410289001927 16S rRNA interaction site [nucleotide binding]; other site 410289001928 streptomycin interaction site [chemical binding]; other site 410289001929 23S rRNA interaction site [nucleotide binding]; other site 410289001930 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 410289001931 30S ribosomal protein S7; Validated; Region: PRK05302 410289001932 elongation factor G; Reviewed; Region: PRK00007 410289001933 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 410289001934 G1 box; other site 410289001935 putative GEF interaction site [polypeptide binding]; other site 410289001936 GTP/Mg2+ binding site [chemical binding]; other site 410289001937 Switch I region; other site 410289001938 G2 box; other site 410289001939 G3 box; other site 410289001940 Switch II region; other site 410289001941 G4 box; other site 410289001942 G5 box; other site 410289001943 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 410289001944 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 410289001945 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 410289001946 elongation factor Tu; Reviewed; Region: PRK00049 410289001947 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 410289001948 G1 box; other site 410289001949 GEF interaction site [polypeptide binding]; other site 410289001950 GTP/Mg2+ binding site [chemical binding]; other site 410289001951 Switch I region; other site 410289001952 G2 box; other site 410289001953 G3 box; other site 410289001954 Switch II region; other site 410289001955 G4 box; other site 410289001956 G5 box; other site 410289001957 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 410289001958 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 410289001959 Antibiotic Binding Site [chemical binding]; other site 410289001960 Short C-terminal domain; Region: SHOCT; pfam09851 410289001961 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 410289001962 classical (c) SDRs; Region: SDR_c; cd05233 410289001963 NAD(P) binding site [chemical binding]; other site 410289001964 active site 410289001965 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 410289001966 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 410289001967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 410289001968 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 410289001969 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289001970 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 410289001971 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 410289001972 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 410289001973 FeS/SAM binding site; other site 410289001974 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 410289001975 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 410289001976 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 410289001977 phosphate binding site [ion binding]; other site 410289001978 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 410289001979 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 410289001980 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 410289001981 Probable Catalytic site; other site 410289001982 metal-binding site 410289001983 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 410289001984 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 410289001985 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 410289001986 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 410289001987 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 410289001988 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 410289001989 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 410289001990 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 410289001991 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 410289001992 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 410289001993 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 410289001994 putative translocon binding site; other site 410289001995 protein-rRNA interface [nucleotide binding]; other site 410289001996 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 410289001997 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 410289001998 G-X-X-G motif; other site 410289001999 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 410289002000 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 410289002001 23S rRNA interface [nucleotide binding]; other site 410289002002 5S rRNA interface [nucleotide binding]; other site 410289002003 putative antibiotic binding site [chemical binding]; other site 410289002004 L25 interface [polypeptide binding]; other site 410289002005 L27 interface [polypeptide binding]; other site 410289002006 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 410289002007 putative translocon interaction site; other site 410289002008 23S rRNA interface [nucleotide binding]; other site 410289002009 signal recognition particle (SRP54) interaction site; other site 410289002010 L23 interface [polypeptide binding]; other site 410289002011 trigger factor interaction site; other site 410289002012 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 410289002013 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 410289002014 Sulfatase; Region: Sulfatase; pfam00884 410289002015 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 410289002016 Uncharacterized conserved protein [Function unknown]; Region: COG1262 410289002017 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 410289002018 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 410289002019 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 410289002020 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 410289002021 RNA binding site [nucleotide binding]; other site 410289002022 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 410289002023 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 410289002024 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 410289002025 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 410289002026 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 410289002027 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 410289002028 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 410289002029 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 410289002030 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 410289002031 5S rRNA interface [nucleotide binding]; other site 410289002032 23S rRNA interface [nucleotide binding]; other site 410289002033 L5 interface [polypeptide binding]; other site 410289002034 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 410289002035 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 410289002036 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 410289002037 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 410289002038 23S rRNA binding site [nucleotide binding]; other site 410289002039 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 410289002040 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 410289002041 tandem repeat interface [polypeptide binding]; other site 410289002042 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 410289002043 oligomer interface [polypeptide binding]; other site 410289002044 active site residues [active] 410289002045 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 410289002046 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 410289002047 tandem repeat interface [polypeptide binding]; other site 410289002048 oligomer interface [polypeptide binding]; other site 410289002049 active site residues [active] 410289002050 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 410289002051 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 410289002052 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 410289002053 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 410289002054 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 410289002055 intersubunit interface [polypeptide binding]; other site 410289002056 active site 410289002057 Zn2+ binding site [ion binding]; other site 410289002058 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 410289002059 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 410289002060 NAD binding site [chemical binding]; other site 410289002061 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 410289002062 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 410289002063 nucleotide binding site [chemical binding]; other site 410289002064 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 410289002065 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 410289002066 Coenzyme A binding pocket [chemical binding]; other site 410289002067 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 410289002068 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 410289002069 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 410289002070 SecY translocase; Region: SecY; pfam00344 410289002071 adenylate kinase; Reviewed; Region: adk; PRK00279 410289002072 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 410289002073 AMP-binding site [chemical binding]; other site 410289002074 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 410289002075 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 410289002076 active site 410289002077 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 410289002078 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 410289002079 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 410289002080 DNA binding residues [nucleotide binding] 410289002081 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 410289002082 Putative zinc-finger; Region: zf-HC2; pfam13490 410289002083 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 410289002084 MarR family; Region: MarR; pfam01047 410289002085 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 410289002086 TIGR03086 family protein; Region: TIGR03086 410289002087 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 410289002088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 410289002089 Transposase; Region: DDE_Tnp_ISL3; pfam01610 410289002090 Helix-turn-helix domain; Region: HTH_17; pfam12728 410289002091 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 410289002092 PE family; Region: PE; pfam00934 410289002093 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 410289002094 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 410289002095 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 410289002096 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 410289002097 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289002098 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 410289002099 substrate binding pocket [chemical binding]; other site 410289002100 FAD binding site [chemical binding]; other site 410289002101 catalytic base [active] 410289002102 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 410289002103 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 410289002104 tetrameric interface [polypeptide binding]; other site 410289002105 NAD binding site [chemical binding]; other site 410289002106 catalytic residues [active] 410289002107 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 410289002108 catalytic core [active] 410289002109 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289002110 PPE family; Region: PPE; pfam00823 410289002111 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289002112 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289002113 Helix-turn-helix domain; Region: HTH_28; pfam13518 410289002114 Winged helix-turn helix; Region: HTH_29; pfam13551 410289002115 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 410289002116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 410289002117 active site 410289002118 phosphorylation site [posttranslational modification] 410289002119 intermolecular recognition site; other site 410289002120 dimerization interface [polypeptide binding]; other site 410289002121 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 410289002122 DNA binding site [nucleotide binding] 410289002123 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 410289002124 dimerization interface [polypeptide binding]; other site 410289002125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 410289002126 dimer interface [polypeptide binding]; other site 410289002127 phosphorylation site [posttranslational modification] 410289002128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 410289002129 ATP binding site [chemical binding]; other site 410289002130 Mg2+ binding site [ion binding]; other site 410289002131 G-X-G motif; other site 410289002132 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 410289002133 nucleotide binding site/active site [active] 410289002134 HIT family signature motif; other site 410289002135 catalytic residue [active] 410289002136 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 410289002137 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 410289002138 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 410289002139 NAD binding site [chemical binding]; other site 410289002140 catalytic Zn binding site [ion binding]; other site 410289002141 substrate binding site [chemical binding]; other site 410289002142 structural Zn binding site [ion binding]; other site 410289002143 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 410289002144 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 410289002145 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 410289002146 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289002147 Cytochrome P450; Region: p450; cl12078 410289002148 short chain dehydrogenase; Provisional; Region: PRK07775 410289002149 classical (c) SDRs; Region: SDR_c; cd05233 410289002150 NAD(P) binding site [chemical binding]; other site 410289002151 active site 410289002152 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289002153 Cytochrome P450; Region: p450; cl12078 410289002154 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289002155 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 410289002156 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 410289002157 NAD binding site [chemical binding]; other site 410289002158 catalytic residues [active] 410289002159 short chain dehydrogenase; Provisional; Region: PRK07774 410289002160 classical (c) SDRs; Region: SDR_c; cd05233 410289002161 NAD(P) binding site [chemical binding]; other site 410289002162 active site 410289002163 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 410289002164 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 410289002165 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 410289002166 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 410289002167 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 410289002168 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 410289002169 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 410289002170 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 410289002171 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 410289002172 Predicted esterase [General function prediction only]; Region: COG0627 410289002173 S-formylglutathione hydrolase; Region: PLN02442 410289002174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 410289002175 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 410289002176 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 410289002177 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 410289002178 tetramer interface [polypeptide binding]; other site 410289002179 active site 410289002180 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289002181 Cytochrome P450; Region: p450; cl12078 410289002182 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 410289002183 ATP binding site [chemical binding]; other site 410289002184 active site 410289002185 substrate binding site [chemical binding]; other site 410289002186 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 410289002187 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 410289002188 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 410289002189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289002190 putative substrate translocation pore; other site 410289002191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289002192 Predicted deacetylase [General function prediction only]; Region: COG3233 410289002193 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 410289002194 putative active site [active] 410289002195 putative Zn binding site [ion binding]; other site 410289002196 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 410289002197 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 410289002198 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 410289002199 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 410289002200 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 410289002201 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 410289002202 putative active site [active] 410289002203 catalytic triad [active] 410289002204 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 410289002205 Transglutaminase/protease-like homologues; Region: TGc; smart00460 410289002206 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 410289002207 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 410289002208 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 410289002209 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 410289002210 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 410289002211 DNA-binding site [nucleotide binding]; DNA binding site 410289002212 UTRA domain; Region: UTRA; pfam07702 410289002213 Uncharacterized conserved protein [Function unknown]; Region: COG1359 410289002214 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 410289002215 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 410289002216 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 410289002217 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 410289002218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 410289002219 Transposase; Region: DEDD_Tnp_IS110; pfam01548 410289002220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 410289002221 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 410289002222 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 410289002223 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 410289002224 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 410289002225 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 410289002226 active site 410289002227 metal binding site [ion binding]; metal-binding site 410289002228 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 410289002229 active site 410289002230 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 410289002231 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 410289002232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 410289002233 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 410289002234 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 410289002235 dimerization interface [polypeptide binding]; other site 410289002236 ATP binding site [chemical binding]; other site 410289002237 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 410289002238 dimerization interface [polypeptide binding]; other site 410289002239 ATP binding site [chemical binding]; other site 410289002240 CAAX protease self-immunity; Region: Abi; pfam02517 410289002241 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 410289002242 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 410289002243 active site 410289002244 metal binding site [ion binding]; metal-binding site 410289002245 hexamer interface [polypeptide binding]; other site 410289002246 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 410289002247 amidophosphoribosyltransferase; Provisional; Region: PRK07847 410289002248 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 410289002249 active site 410289002250 tetramer interface [polypeptide binding]; other site 410289002251 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 410289002252 active site 410289002253 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 410289002254 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 410289002255 dimerization interface [polypeptide binding]; other site 410289002256 putative ATP binding site [chemical binding]; other site 410289002257 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 410289002258 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 410289002259 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 410289002260 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 410289002261 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 410289002262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289002263 catalytic residue [active] 410289002264 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 410289002265 heme-binding site [chemical binding]; other site 410289002266 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 410289002267 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 410289002268 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 410289002269 active site residue [active] 410289002270 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 410289002271 active site residue [active] 410289002272 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 410289002273 catalytic residues [active] 410289002274 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 410289002275 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 410289002276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 410289002277 DNA binding site [nucleotide binding] 410289002278 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 410289002279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 410289002280 Coenzyme A binding pocket [chemical binding]; other site 410289002281 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 410289002282 Walker A/P-loop; other site 410289002283 ATP binding site [chemical binding]; other site 410289002284 Q-loop/lid; other site 410289002285 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 410289002286 PhoU domain; Region: PhoU; pfam01895 410289002287 PhoU domain; Region: PhoU; pfam01895 410289002288 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 410289002289 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 410289002290 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 410289002291 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 410289002292 FMN binding site [chemical binding]; other site 410289002293 active site 410289002294 catalytic residues [active] 410289002295 substrate binding site [chemical binding]; other site 410289002296 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 410289002297 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 410289002298 homodimer interface [polypeptide binding]; other site 410289002299 putative substrate binding pocket [chemical binding]; other site 410289002300 diiron center [ion binding]; other site 410289002301 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289002302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 410289002303 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 410289002304 dimerization interface [polypeptide binding]; other site 410289002305 putative DNA binding site [nucleotide binding]; other site 410289002306 putative Zn2+ binding site [ion binding]; other site 410289002307 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 410289002308 dimer interface [polypeptide binding]; other site 410289002309 catalytic motif [active] 410289002310 nucleoside/Zn binding site; other site 410289002311 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 410289002312 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 410289002313 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 410289002314 TIGR04255 family protein; Region: sporadTIGR04255 410289002315 PE family; Region: PE; pfam00934 410289002316 PE family; Region: PE; pfam00934 410289002317 PknH-like extracellular domain; Region: PknH_C; pfam14032 410289002318 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 410289002319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 410289002320 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 410289002321 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 410289002322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289002323 S-adenosylmethionine binding site [chemical binding]; other site 410289002324 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 410289002325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289002326 putative substrate translocation pore; other site 410289002327 Major Facilitator Superfamily; Region: MFS_1; pfam07690 410289002328 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 410289002329 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 410289002330 tetramer interface [polypeptide binding]; other site 410289002331 TPP-binding site [chemical binding]; other site 410289002332 heterodimer interface [polypeptide binding]; other site 410289002333 phosphorylation loop region [posttranslational modification] 410289002334 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 410289002335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 410289002336 active site 410289002337 phosphorylation site [posttranslational modification] 410289002338 intermolecular recognition site; other site 410289002339 dimerization interface [polypeptide binding]; other site 410289002340 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 410289002341 DNA binding residues [nucleotide binding] 410289002342 dimerization interface [polypeptide binding]; other site 410289002343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 410289002344 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 410289002345 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 410289002346 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 410289002347 Multicopper oxidase; Region: Cu-oxidase; pfam00394 410289002348 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 410289002349 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 410289002350 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 410289002351 dimer interface [polypeptide binding]; other site 410289002352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289002353 catalytic residue [active] 410289002354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289002355 multidrug resistance protein MdtH; Provisional; Region: PRK11646 410289002356 putative substrate translocation pore; other site 410289002357 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 410289002358 short chain dehydrogenase; Provisional; Region: PRK05876 410289002359 classical (c) SDRs; Region: SDR_c; cd05233 410289002360 NAD(P) binding site [chemical binding]; other site 410289002361 active site 410289002362 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289002363 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 410289002364 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 410289002365 dimer interface [polypeptide binding]; other site 410289002366 PYR/PP interface [polypeptide binding]; other site 410289002367 TPP binding site [chemical binding]; other site 410289002368 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 410289002369 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 410289002370 TPP-binding site [chemical binding]; other site 410289002371 dimer interface [polypeptide binding]; other site 410289002372 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 410289002373 putative hydrophobic ligand binding site [chemical binding]; other site 410289002374 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 410289002375 CoA-transferase family III; Region: CoA_transf_3; pfam02515 410289002376 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 410289002377 putative hydrophobic ligand binding site [chemical binding]; other site 410289002378 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 410289002379 putative hydrophobic ligand binding site [chemical binding]; other site 410289002380 aminotransferase; Validated; Region: PRK07777 410289002381 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 410289002382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289002383 homodimer interface [polypeptide binding]; other site 410289002384 catalytic residue [active] 410289002385 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 410289002386 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 410289002387 dimer interface [polypeptide binding]; other site 410289002388 active site 410289002389 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 410289002390 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289002391 substrate binding site [chemical binding]; other site 410289002392 oxyanion hole (OAH) forming residues; other site 410289002393 trimer interface [polypeptide binding]; other site 410289002394 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 410289002395 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 410289002396 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 410289002397 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 410289002398 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 410289002399 ATP binding site [chemical binding]; other site 410289002400 putative Mg++ binding site [ion binding]; other site 410289002401 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 410289002402 nucleotide binding region [chemical binding]; other site 410289002403 ATP-binding site [chemical binding]; other site 410289002404 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 410289002405 WYL domain; Region: WYL; pfam13280 410289002406 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 410289002407 trimer interface [polypeptide binding]; other site 410289002408 dimer interface [polypeptide binding]; other site 410289002409 putative active site [active] 410289002410 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 410289002411 MPT binding site; other site 410289002412 trimer interface [polypeptide binding]; other site 410289002413 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 410289002414 MoaE homodimer interface [polypeptide binding]; other site 410289002415 MoaD interaction [polypeptide binding]; other site 410289002416 active site residues [active] 410289002417 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 410289002418 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 410289002419 MoaE interaction surface [polypeptide binding]; other site 410289002420 MoeB interaction surface [polypeptide binding]; other site 410289002421 thiocarboxylated glycine; other site 410289002422 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 410289002423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 410289002424 FeS/SAM binding site; other site 410289002425 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 410289002426 hypothetical protein; Provisional; Region: PRK11770 410289002427 Domain of unknown function (DUF307); Region: DUF307; pfam03733 410289002428 Domain of unknown function (DUF307); Region: DUF307; pfam03733 410289002429 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 410289002430 DNA-binding site [nucleotide binding]; DNA binding site 410289002431 RNA-binding motif; other site 410289002432 PE family; Region: PE; pfam00934 410289002433 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289002434 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289002435 active site 410289002436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 410289002437 FIST N domain; Region: FIST; pfam08495 410289002438 FIST C domain; Region: FIST_C; pfam10442 410289002439 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 410289002440 H+ Antiporter protein; Region: 2A0121; TIGR00900 410289002441 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 410289002442 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289002443 PPE family; Region: PPE; pfam00823 410289002444 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289002445 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289002446 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 410289002447 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 410289002448 MarR family; Region: MarR; pfam01047 410289002449 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 410289002450 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 410289002451 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 410289002452 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 410289002453 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 410289002454 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 410289002455 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 410289002456 catalytic residue [active] 410289002457 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 410289002458 Ferredoxin [Energy production and conversion]; Region: COG1146 410289002459 4Fe-4S binding domain; Region: Fer4; pfam00037 410289002460 ferredoxin-NADP+ reductase; Region: PLN02852 410289002461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 410289002462 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 410289002463 putative dimer interface [polypeptide binding]; other site 410289002464 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 410289002465 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 410289002466 putative catalytic site [active] 410289002467 putative phosphate binding site [ion binding]; other site 410289002468 putative metal binding site [ion binding]; other site 410289002469 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 410289002470 dimer interface [polypeptide binding]; other site 410289002471 Citrate synthase; Region: Citrate_synt; pfam00285 410289002472 active site 410289002473 citrylCoA binding site [chemical binding]; other site 410289002474 oxalacetate/citrate binding site [chemical binding]; other site 410289002475 coenzyme A binding site [chemical binding]; other site 410289002476 catalytic triad [active] 410289002477 Predicted ATPase [General function prediction only]; Region: COG3903 410289002478 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 410289002479 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 410289002480 DNA binding residues [nucleotide binding] 410289002481 dimerization interface [polypeptide binding]; other site 410289002482 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 410289002483 cyclase homology domain; Region: CHD; cd07302 410289002484 nucleotidyl binding site; other site 410289002485 metal binding site [ion binding]; metal-binding site 410289002486 dimer interface [polypeptide binding]; other site 410289002487 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 410289002488 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 410289002489 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 410289002490 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 410289002491 AAA ATPase domain; Region: AAA_16; pfam13191 410289002492 Predicted ATPase [General function prediction only]; Region: COG3903 410289002493 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 410289002494 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 410289002495 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 410289002496 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 410289002497 dimer interface [polypeptide binding]; other site 410289002498 active site 410289002499 citrylCoA binding site [chemical binding]; other site 410289002500 NADH binding [chemical binding]; other site 410289002501 cationic pore residues; other site 410289002502 oxalacetate/citrate binding site [chemical binding]; other site 410289002503 coenzyme A binding site [chemical binding]; other site 410289002504 catalytic triad [active] 410289002505 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 410289002506 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 410289002507 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 410289002508 BON domain; Region: BON; pfam04972 410289002509 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 410289002510 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 410289002511 ligand binding site [chemical binding]; other site 410289002512 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 410289002513 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 410289002514 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 410289002515 dimerization interface [polypeptide binding]; other site 410289002516 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 410289002517 dimer interface [polypeptide binding]; other site 410289002518 phosphorylation site [posttranslational modification] 410289002519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 410289002520 Mg2+ binding site [ion binding]; other site 410289002521 G-X-G motif; other site 410289002522 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 410289002523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 410289002524 active site 410289002525 phosphorylation site [posttranslational modification] 410289002526 intermolecular recognition site; other site 410289002527 dimerization interface [polypeptide binding]; other site 410289002528 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 410289002529 DNA binding site [nucleotide binding] 410289002530 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 410289002531 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 410289002532 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 410289002533 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289002534 substrate binding site [chemical binding]; other site 410289002535 oxyanion hole (OAH) forming residues; other site 410289002536 trimer interface [polypeptide binding]; other site 410289002537 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 410289002538 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 410289002539 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 410289002540 Beta-lactamase; Region: Beta-lactamase; pfam00144 410289002541 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 410289002542 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 410289002543 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 410289002544 Soluble P-type ATPase [General function prediction only]; Region: COG4087 410289002545 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 410289002546 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 410289002547 hydrophobic ligand binding site; other site 410289002548 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 410289002549 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 410289002550 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 410289002551 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 410289002552 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 410289002553 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 410289002554 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 410289002555 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 410289002556 active site 410289002557 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289002558 PPE family; Region: PPE; pfam00823 410289002559 PE family; Region: PE; pfam00934 410289002560 BCCT family transporter; Region: BCCT; pfam02028 410289002561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 410289002562 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 410289002563 Coenzyme A binding pocket [chemical binding]; other site 410289002564 Transposase, Mutator family; Region: Transposase_mut; pfam00872 410289002565 MULE transposase domain; Region: MULE; pfam10551 410289002566 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 410289002567 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 410289002568 catalytic residues [active] 410289002569 catalytic nucleophile [active] 410289002570 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 410289002571 Probable transposase; Region: OrfB_IS605; pfam01385 410289002572 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 410289002573 putative active site pocket [active] 410289002574 dimerization interface [polypeptide binding]; other site 410289002575 putative catalytic residue [active] 410289002576 Phage-related replication protein [General function prediction only]; Region: COG4195 410289002577 manganese transport protein MntH; Reviewed; Region: PRK00701 410289002578 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 410289002579 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 410289002580 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 410289002581 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 410289002582 short chain dehydrogenase; Provisional; Region: PRK07814 410289002583 classical (c) SDRs; Region: SDR_c; cd05233 410289002584 NAD(P) binding site [chemical binding]; other site 410289002585 active site 410289002586 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 410289002587 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 410289002588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289002589 dimer interface [polypeptide binding]; other site 410289002590 conserved gate region; other site 410289002591 putative PBP binding loops; other site 410289002592 ABC-ATPase subunit interface; other site 410289002593 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 410289002594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289002595 dimer interface [polypeptide binding]; other site 410289002596 conserved gate region; other site 410289002597 putative PBP binding loops; other site 410289002598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 410289002599 ABC-ATPase subunit interface; other site 410289002600 Uncharacterized conserved protein [Function unknown]; Region: COG3391 410289002601 NHL repeat; Region: NHL; pfam01436 410289002602 NHL repeat; Region: NHL; pfam01436 410289002603 NHL repeat; Region: NHL; pfam01436 410289002604 NHL repeat; Region: NHL; pfam01436 410289002605 NHL repeat; Region: NHL; pfam01436 410289002606 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 410289002607 Catalytic domain of Protein Kinases; Region: PKc; cd00180 410289002608 active site 410289002609 ATP binding site [chemical binding]; other site 410289002610 substrate binding site [chemical binding]; other site 410289002611 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 410289002612 substrate binding site [chemical binding]; other site 410289002613 activation loop (A-loop); other site 410289002614 activation loop (A-loop); other site 410289002615 PBP superfamily domain; Region: PBP_like_2; cl17296 410289002616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289002617 Walker A/P-loop; other site 410289002618 ATP binding site [chemical binding]; other site 410289002619 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 410289002620 Q-loop/lid; other site 410289002621 ABC transporter signature motif; other site 410289002622 Walker B; other site 410289002623 D-loop; other site 410289002624 H-loop/switch region; other site 410289002625 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 410289002626 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 410289002627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289002628 dimer interface [polypeptide binding]; other site 410289002629 conserved gate region; other site 410289002630 putative PBP binding loops; other site 410289002631 ABC-ATPase subunit interface; other site 410289002632 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 410289002633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289002634 dimer interface [polypeptide binding]; other site 410289002635 conserved gate region; other site 410289002636 putative PBP binding loops; other site 410289002637 ABC-ATPase subunit interface; other site 410289002638 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 410289002639 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 410289002640 putative DNA binding site [nucleotide binding]; other site 410289002641 putative homodimer interface [polypeptide binding]; other site 410289002642 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 410289002643 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 410289002644 nucleotide binding site [chemical binding]; other site 410289002645 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 410289002646 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 410289002647 active site 410289002648 DNA binding site [nucleotide binding] 410289002649 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 410289002650 DNA binding site [nucleotide binding] 410289002651 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 410289002652 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 410289002653 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 410289002654 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 410289002655 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 410289002656 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 410289002657 anti sigma factor interaction site; other site 410289002658 regulatory phosphorylation site [posttranslational modification]; other site 410289002659 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 410289002660 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 410289002661 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 410289002662 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 410289002663 short chain dehydrogenase; Provisional; Region: PRK08251 410289002664 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 410289002665 putative NAD(P) binding site [chemical binding]; other site 410289002666 active site 410289002667 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 410289002668 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 410289002669 active site 410289002670 dimer interface [polypeptide binding]; other site 410289002671 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 410289002672 dimer interface [polypeptide binding]; other site 410289002673 active site 410289002674 hypothetical protein; Provisional; Region: PRK07857 410289002675 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 410289002676 Part of AAA domain; Region: AAA_19; pfam13245 410289002677 Family description; Region: UvrD_C_2; pfam13538 410289002678 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 410289002679 Peptidase family M23; Region: Peptidase_M23; pfam01551 410289002680 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 410289002681 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 410289002682 CoA-ligase; Region: Ligase_CoA; pfam00549 410289002683 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 410289002684 CoA binding domain; Region: CoA_binding; smart00881 410289002685 CoA-ligase; Region: Ligase_CoA; pfam00549 410289002686 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 410289002687 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 410289002688 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 410289002689 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 410289002690 active site 410289002691 substrate binding site [chemical binding]; other site 410289002692 cosubstrate binding site; other site 410289002693 catalytic site [active] 410289002694 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 410289002695 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 410289002696 purine monophosphate binding site [chemical binding]; other site 410289002697 dimer interface [polypeptide binding]; other site 410289002698 putative catalytic residues [active] 410289002699 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 410289002700 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 410289002701 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 410289002702 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 410289002703 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 410289002704 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 410289002705 metal ion-dependent adhesion site (MIDAS); other site 410289002706 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 410289002707 homotetrameric interface [polypeptide binding]; other site 410289002708 putative active site [active] 410289002709 metal binding site [ion binding]; metal-binding site 410289002710 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 410289002711 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 410289002712 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 410289002713 putative homodimer interface [polypeptide binding]; other site 410289002714 putative homotetramer interface [polypeptide binding]; other site 410289002715 allosteric switch controlling residues; other site 410289002716 putative metal binding site [ion binding]; other site 410289002717 putative homodimer-homodimer interface [polypeptide binding]; other site 410289002718 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 410289002719 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 410289002720 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 410289002721 Soluble P-type ATPase [General function prediction only]; Region: COG4087 410289002722 enoyl-CoA hydratase; Provisional; Region: PRK07827 410289002723 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289002724 substrate binding site [chemical binding]; other site 410289002725 oxyanion hole (OAH) forming residues; other site 410289002726 trimer interface [polypeptide binding]; other site 410289002727 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289002728 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 410289002729 active site 410289002730 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 410289002731 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 410289002732 ATP-grasp domain; Region: ATP-grasp_4; cl17255 410289002733 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 410289002734 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 410289002735 carboxyltransferase (CT) interaction site; other site 410289002736 biotinylation site [posttranslational modification]; other site 410289002737 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 410289002738 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 410289002739 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289002740 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289002741 active site 410289002742 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 410289002743 PE family; Region: PE; pfam00934 410289002744 PE family; Region: PE; pfam00934 410289002745 Uncharacterized conserved protein [Function unknown]; Region: COG3391 410289002746 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 410289002747 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 410289002748 PE family; Region: PE; pfam00934 410289002749 Uncharacterized conserved protein [Function unknown]; Region: COG3391 410289002750 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 410289002751 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 410289002752 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 410289002753 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 410289002754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 410289002755 active site 410289002756 phosphorylation site [posttranslational modification] 410289002757 intermolecular recognition site; other site 410289002758 dimerization interface [polypeptide binding]; other site 410289002759 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 410289002760 DNA binding site [nucleotide binding] 410289002761 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 410289002762 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 410289002763 dimerization interface [polypeptide binding]; other site 410289002764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 410289002765 dimer interface [polypeptide binding]; other site 410289002766 phosphorylation site [posttranslational modification] 410289002767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 410289002768 ATP binding site [chemical binding]; other site 410289002769 Mg2+ binding site [ion binding]; other site 410289002770 G-X-G motif; other site 410289002771 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 410289002772 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 410289002773 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 410289002774 MPT binding site; other site 410289002775 trimer interface [polypeptide binding]; other site 410289002776 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 410289002777 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 410289002778 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 410289002779 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 410289002780 Walker A/P-loop; other site 410289002781 ATP binding site [chemical binding]; other site 410289002782 Q-loop/lid; other site 410289002783 ABC transporter signature motif; other site 410289002784 Walker B; other site 410289002785 D-loop; other site 410289002786 H-loop/switch region; other site 410289002787 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 410289002788 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 410289002789 FtsX-like permease family; Region: FtsX; pfam02687 410289002790 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 410289002791 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 410289002792 FtsX-like permease family; Region: FtsX; pfam02687 410289002793 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 410289002794 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 410289002795 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 410289002796 substrate binding pocket [chemical binding]; other site 410289002797 chain length determination region; other site 410289002798 substrate-Mg2+ binding site; other site 410289002799 catalytic residues [active] 410289002800 aspartate-rich region 1; other site 410289002801 active site lid residues [active] 410289002802 aspartate-rich region 2; other site 410289002803 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 410289002804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 410289002805 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 410289002806 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 410289002807 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 410289002808 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 410289002809 active site 410289002810 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 410289002811 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 410289002812 dimer interface [polypeptide binding]; other site 410289002813 putative functional site; other site 410289002814 putative MPT binding site; other site 410289002815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 410289002816 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 410289002817 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 410289002818 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 410289002819 ligand binding site [chemical binding]; other site 410289002820 flexible hinge region; other site 410289002821 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 410289002822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 410289002823 Coenzyme A binding pocket [chemical binding]; other site 410289002824 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 410289002825 arginine deiminase; Provisional; Region: PRK01388 410289002826 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 410289002827 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 410289002828 Predicted methyltransferases [General function prediction only]; Region: COG0313 410289002829 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 410289002830 putative SAM binding site [chemical binding]; other site 410289002831 putative homodimer interface [polypeptide binding]; other site 410289002832 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 410289002833 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 410289002834 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 410289002835 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 410289002836 active site 410289002837 HIGH motif; other site 410289002838 KMSKS motif; other site 410289002839 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 410289002840 tRNA binding surface [nucleotide binding]; other site 410289002841 anticodon binding site; other site 410289002842 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 410289002843 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 410289002844 active site 410289002845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 410289002846 Domain of unknown function (DUF348); Region: DUF348; pfam03990 410289002847 Domain of unknown function (DUF348); Region: DUF348; pfam03990 410289002848 G5 domain; Region: G5; pfam07501 410289002849 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 410289002850 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 410289002851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289002852 S-adenosylmethionine binding site [chemical binding]; other site 410289002853 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 410289002854 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 410289002855 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 410289002856 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 410289002857 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289002858 acyl-activating enzyme (AAE) consensus motif; other site 410289002859 AMP binding site [chemical binding]; other site 410289002860 active site 410289002861 CoA binding site [chemical binding]; other site 410289002862 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 410289002863 putative active site [active] 410289002864 catalytic residue [active] 410289002865 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 410289002866 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 410289002867 5S rRNA interface [nucleotide binding]; other site 410289002868 CTC domain interface [polypeptide binding]; other site 410289002869 L16 interface [polypeptide binding]; other site 410289002870 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 410289002871 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 410289002872 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 410289002873 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 410289002874 active site 410289002875 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 410289002876 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 410289002877 Substrate binding site; other site 410289002878 Mg++ binding site; other site 410289002879 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 410289002880 active site 410289002881 substrate binding site [chemical binding]; other site 410289002882 CoA binding site [chemical binding]; other site 410289002883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289002884 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289002885 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 410289002886 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 410289002887 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 410289002888 ATP binding site [chemical binding]; other site 410289002889 putative Mg++ binding site [ion binding]; other site 410289002890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 410289002891 nucleotide binding region [chemical binding]; other site 410289002892 ATP-binding site [chemical binding]; other site 410289002893 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 410289002894 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 410289002895 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 410289002896 homodimer interface [polypeptide binding]; other site 410289002897 metal binding site [ion binding]; metal-binding site 410289002898 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 410289002899 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 410289002900 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 410289002901 N-acetyl-D-glucosamine binding site [chemical binding]; other site 410289002902 enolase; Provisional; Region: eno; PRK00077 410289002903 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 410289002904 dimer interface [polypeptide binding]; other site 410289002905 metal binding site [ion binding]; metal-binding site 410289002906 substrate binding pocket [chemical binding]; other site 410289002907 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 410289002908 Septum formation initiator; Region: DivIC; pfam04977 410289002909 Uncharacterized conserved protein [Function unknown]; Region: COG1507 410289002910 exopolyphosphatase; Region: exo_poly_only; TIGR03706 410289002911 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 410289002912 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 410289002913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 410289002914 active site 410289002915 phosphorylation site [posttranslational modification] 410289002916 intermolecular recognition site; other site 410289002917 dimerization interface [polypeptide binding]; other site 410289002918 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 410289002919 DNA binding site [nucleotide binding] 410289002920 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 410289002921 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 410289002922 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 410289002923 Ligand Binding Site [chemical binding]; other site 410289002924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 410289002925 dimer interface [polypeptide binding]; other site 410289002926 phosphorylation site [posttranslational modification] 410289002927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 410289002928 ATP binding site [chemical binding]; other site 410289002929 Mg2+ binding site [ion binding]; other site 410289002930 G-X-G motif; other site 410289002931 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 410289002932 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 410289002933 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 410289002934 Soluble P-type ATPase [General function prediction only]; Region: COG4087 410289002935 potassium-transporting ATPase subunit C; Provisional; Region: PRK14001 410289002936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 410289002937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 410289002938 dimer interface [polypeptide binding]; other site 410289002939 phosphorylation site [posttranslational modification] 410289002940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 410289002941 ATP binding site [chemical binding]; other site 410289002942 Mg2+ binding site [ion binding]; other site 410289002943 G-X-G motif; other site 410289002944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 410289002945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 410289002946 active site 410289002947 phosphorylation site [posttranslational modification] 410289002948 intermolecular recognition site; other site 410289002949 dimerization interface [polypeptide binding]; other site 410289002950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 410289002951 DNA binding site [nucleotide binding] 410289002952 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 410289002953 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 410289002954 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 410289002955 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 410289002956 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 410289002957 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289002958 PPE family; Region: PPE; pfam00823 410289002959 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 410289002960 PE family; Region: PE; pfam00934 410289002961 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 410289002962 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 410289002963 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 410289002964 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 410289002965 Predicted transcriptional regulator [Transcription]; Region: COG5340 410289002966 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 410289002967 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 410289002968 Transposase, Mutator family; Region: Transposase_mut; pfam00872 410289002969 MULE transposase domain; Region: MULE; pfam10551 410289002970 Transcriptional regulators [Transcription]; Region: MarR; COG1846 410289002971 MarR family; Region: MarR_2; pfam12802 410289002972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289002973 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 410289002974 NAD(P) binding site [chemical binding]; other site 410289002975 active site 410289002976 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 410289002977 Helix-turn-helix domain; Region: HTH_17; pfam12728 410289002978 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 410289002979 Domain of unknown function (DUF427); Region: DUF427; cl00998 410289002980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 410289002981 Uncharacterized conserved protein [Function unknown]; Region: COG3391 410289002982 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 410289002983 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 410289002984 dimer interface [polypeptide binding]; other site 410289002985 acyl-activating enzyme (AAE) consensus motif; other site 410289002986 putative active site [active] 410289002987 AMP binding site [chemical binding]; other site 410289002988 putative CoA binding site [chemical binding]; other site 410289002989 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 410289002990 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 410289002991 hydrophobic ligand binding site; other site 410289002992 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 410289002993 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 410289002994 putative active site [active] 410289002995 putative dimer interface [polypeptide binding]; other site 410289002996 Patatin-like phospholipase; Region: Patatin; pfam01734 410289002997 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 410289002998 nucleophile elbow; other site 410289002999 hypothetical protein; Provisional; Region: PRK10279 410289003000 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 410289003001 active site 410289003002 nucleophile elbow; other site 410289003003 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 410289003004 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 410289003005 active site residue [active] 410289003006 PE family; Region: PE; pfam00934 410289003007 PE family; Region: PE; pfam00934 410289003008 I-RD02, 717 bp. Region of Difference I-RD02, inserted region in Mycobacterium bovis BCG Pasteur (position 1221856..1222572, 717bp) and Mycobacterium bovis AF2122/97 (position 1191818..1192534, 717bp) compared to Mycobacterium tuberculosis H37Rv2 (position: 1191366..1191367). In-frame insertion in PE_PGRS20 gene (Rv1068c) 410289003009 Predicted membrane protein [Function unknown]; Region: COG4425 410289003010 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 410289003011 enoyl-CoA hydratase; Provisional; Region: PRK05862 410289003012 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289003013 substrate binding site [chemical binding]; other site 410289003014 oxyanion hole (OAH) forming residues; other site 410289003015 trimer interface [polypeptide binding]; other site 410289003016 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 410289003017 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289003018 substrate binding site [chemical binding]; other site 410289003019 oxyanion hole (OAH) forming residues; other site 410289003020 trimer interface [polypeptide binding]; other site 410289003021 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 410289003022 Predicted membrane protein [Function unknown]; Region: COG4760 410289003023 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 410289003024 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 410289003025 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 410289003026 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 410289003027 dimer interface [polypeptide binding]; other site 410289003028 active site 410289003029 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 410289003030 active site 410289003031 catalytic triad [active] 410289003032 oxyanion hole [active] 410289003033 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 410289003034 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 410289003035 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 410289003036 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 410289003037 dimer interface [polypeptide binding]; other site 410289003038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289003039 catalytic residue [active] 410289003040 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 410289003041 RDD family; Region: RDD; pfam06271 410289003042 cystathionine gamma-synthase; Provisional; Region: PRK07811 410289003043 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 410289003044 homodimer interface [polypeptide binding]; other site 410289003045 substrate-cofactor binding pocket; other site 410289003046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289003047 catalytic residue [active] 410289003048 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 410289003049 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 410289003050 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 410289003051 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 410289003052 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 410289003053 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 410289003054 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 410289003055 catalytic residues [active] 410289003056 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 410289003057 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 410289003058 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 410289003059 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 410289003060 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 410289003061 catalytic residue [active] 410289003062 putative FPP diphosphate binding site; other site 410289003063 putative FPP binding hydrophobic cleft; other site 410289003064 dimer interface [polypeptide binding]; other site 410289003065 putative IPP diphosphate binding site; other site 410289003066 PE family; Region: PE; pfam00934 410289003067 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 410289003068 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 410289003069 putative IPP diphosphate binding site; other site 410289003070 PE family; Region: PE; pfam00934 410289003071 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 410289003072 PE family; Region: PE; pfam00934 410289003073 pantothenate kinase; Provisional; Region: PRK05439 410289003074 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 410289003075 ATP-binding site [chemical binding]; other site 410289003076 CoA-binding site [chemical binding]; other site 410289003077 Mg2+-binding site [ion binding]; other site 410289003078 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 410289003079 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 410289003080 dimer interface [polypeptide binding]; other site 410289003081 active site 410289003082 glycine-pyridoxal phosphate binding site [chemical binding]; other site 410289003083 folate binding site [chemical binding]; other site 410289003084 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 410289003085 dinuclear metal binding motif [ion binding]; other site 410289003086 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 410289003087 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 410289003088 putative active site [active] 410289003089 PhoH-like protein; Region: PhoH; pfam02562 410289003090 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 410289003091 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 410289003092 NodB motif; other site 410289003093 active site 410289003094 catalytic site [active] 410289003095 metal binding site [ion binding]; metal-binding site 410289003096 fumarate hydratase; Reviewed; Region: fumC; PRK00485 410289003097 Class II fumarases; Region: Fumarase_classII; cd01362 410289003098 active site 410289003099 tetramer interface [polypeptide binding]; other site 410289003100 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 410289003101 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 410289003102 putative active site [active] 410289003103 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 410289003104 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 410289003105 Domain of unknown function DUF20; Region: UPF0118; pfam01594 410289003106 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 410289003107 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 410289003108 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 410289003109 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 410289003110 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 410289003111 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 410289003112 putative NAD(P) binding site [chemical binding]; other site 410289003113 active site 410289003114 putative substrate binding site [chemical binding]; other site 410289003115 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 410289003116 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 410289003117 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 410289003118 generic binding surface II; other site 410289003119 generic binding surface I; other site 410289003120 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 410289003121 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 410289003122 Yip1 domain; Region: Yip1; pfam04893 410289003123 GTP-binding protein YchF; Reviewed; Region: PRK09601 410289003124 YchF GTPase; Region: YchF; cd01900 410289003125 G1 box; other site 410289003126 GTP/Mg2+ binding site [chemical binding]; other site 410289003127 Switch I region; other site 410289003128 G2 box; other site 410289003129 Switch II region; other site 410289003130 G3 box; other site 410289003131 G4 box; other site 410289003132 G5 box; other site 410289003133 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 410289003134 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 410289003135 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 410289003136 putative active site [active] 410289003137 Uncharacterized conserved protein [Function unknown]; Region: COG1359 410289003138 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 410289003139 cyclase homology domain; Region: CHD; cd07302 410289003140 nucleotidyl binding site; other site 410289003141 metal binding site [ion binding]; metal-binding site 410289003142 dimer interface [polypeptide binding]; other site 410289003143 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 410289003144 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 410289003145 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 410289003146 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 410289003147 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 410289003148 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 410289003149 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 410289003150 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 410289003151 pyruvate phosphate dikinase; Provisional; Region: PRK05878 410289003152 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 410289003153 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 410289003154 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289003155 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289003156 active site 410289003157 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 410289003158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 410289003159 non-specific DNA binding site [nucleotide binding]; other site 410289003160 salt bridge; other site 410289003161 sequence-specific DNA binding site [nucleotide binding]; other site 410289003162 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 410289003163 Domain of unknown function (DUF955); Region: DUF955; pfam06114 410289003164 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 410289003165 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 410289003166 citrate synthase; Provisional; Region: PRK14033 410289003167 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 410289003168 oxalacetate binding site [chemical binding]; other site 410289003169 citrylCoA binding site [chemical binding]; other site 410289003170 coenzyme A binding site [chemical binding]; other site 410289003171 catalytic triad [active] 410289003172 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 410289003173 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 410289003174 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 410289003175 THF binding site; other site 410289003176 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 410289003177 substrate binding site [chemical binding]; other site 410289003178 THF binding site; other site 410289003179 zinc-binding site [ion binding]; other site 410289003180 PPE family; Region: PPE; pfam00823 410289003181 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 410289003182 active site 410289003183 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 410289003184 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289003185 substrate binding site [chemical binding]; other site 410289003186 oxyanion hole (OAH) forming residues; other site 410289003187 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 410289003188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 410289003189 CAAX protease self-immunity; Region: Abi; pfam02517 410289003190 enoyl-CoA hydratase; Provisional; Region: PRK06688 410289003191 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 410289003192 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289003193 trimer interface [polypeptide binding]; other site 410289003194 enoyl-CoA hydratase; Provisional; Region: PRK06688 410289003195 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289003196 substrate binding site [chemical binding]; other site 410289003197 oxyanion hole (OAH) forming residues; other site 410289003198 trimer interface [polypeptide binding]; other site 410289003199 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 410289003200 CoA-transferase family III; Region: CoA_transf_3; pfam02515 410289003201 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 410289003202 NAD binding site [chemical binding]; other site 410289003203 homodimer interface [polypeptide binding]; other site 410289003204 homotetramer interface [polypeptide binding]; other site 410289003205 active site 410289003206 MMPL family; Region: MMPL; pfam03176 410289003207 MMPL family; Region: MMPL; pfam03176 410289003208 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289003209 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289003210 active site 410289003211 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 410289003212 NAD-dependent deacetylase; Provisional; Region: PRK00481 410289003213 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 410289003214 NAD+ binding site [chemical binding]; other site 410289003215 substrate binding site [chemical binding]; other site 410289003216 Zn binding site [ion binding]; other site 410289003217 Predicted transcriptional regulators [Transcription]; Region: COG1725 410289003218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 410289003219 DNA-binding site [nucleotide binding]; DNA binding site 410289003220 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 410289003221 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 410289003222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 410289003223 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 410289003224 uncharacterized HhH-GPD family protein; Region: TIGR03252 410289003225 minor groove reading motif; other site 410289003226 helix-hairpin-helix signature motif; other site 410289003227 mannosyltransferase; Provisional; Region: pimE; PRK13375 410289003228 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 410289003229 aromatic arch; other site 410289003230 DCoH dimer interaction site [polypeptide binding]; other site 410289003231 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 410289003232 DCoH tetramer interaction site [polypeptide binding]; other site 410289003233 substrate binding site [chemical binding]; other site 410289003234 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 410289003235 active site 410289003236 8-oxo-dGMP binding site [chemical binding]; other site 410289003237 nudix motif; other site 410289003238 metal binding site [ion binding]; metal-binding site 410289003239 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 410289003240 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 410289003241 [4Fe-4S] binding site [ion binding]; other site 410289003242 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 410289003243 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 410289003244 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 410289003245 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 410289003246 molybdopterin cofactor binding site; other site 410289003247 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 410289003248 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 410289003249 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 410289003250 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 410289003251 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 410289003252 G1 box; other site 410289003253 putative GEF interaction site [polypeptide binding]; other site 410289003254 GTP/Mg2+ binding site [chemical binding]; other site 410289003255 Switch I region; other site 410289003256 G2 box; other site 410289003257 G3 box; other site 410289003258 Switch II region; other site 410289003259 G4 box; other site 410289003260 G5 box; other site 410289003261 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 410289003262 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 410289003263 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 410289003264 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 410289003265 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 410289003266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289003267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289003268 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289003269 PPE family; Region: PPE; pfam00823 410289003270 PE family; Region: PE; pfam00934 410289003271 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 410289003272 PE family; Region: PE; pfam00934 410289003273 FO synthase; Reviewed; Region: fbiC; PRK09234 410289003274 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 410289003275 FeS/SAM binding site; other site 410289003276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 410289003277 FeS/SAM binding site; other site 410289003278 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 410289003279 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 410289003280 active site 410289003281 FMN binding site [chemical binding]; other site 410289003282 2,4-decadienoyl-CoA binding site; other site 410289003283 catalytic residue [active] 410289003284 4Fe-4S cluster binding site [ion binding]; other site 410289003285 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 410289003286 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 410289003287 Predicted transcriptional regulators [Transcription]; Region: COG1695 410289003288 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 410289003289 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 410289003290 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 410289003291 4Fe-4S binding domain; Region: Fer4; pfam00037 410289003292 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 410289003293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 410289003294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289003295 homodimer interface [polypeptide binding]; other site 410289003296 catalytic residue [active] 410289003297 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 410289003298 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 410289003299 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 410289003300 ATP binding site [chemical binding]; other site 410289003301 putative Mg++ binding site [ion binding]; other site 410289003302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 410289003303 ATP-binding site [chemical binding]; other site 410289003304 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 410289003305 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289003306 active site 410289003307 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 410289003308 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 410289003309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289003310 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 410289003311 Enoylreductase; Region: PKS_ER; smart00829 410289003312 NAD(P) binding site [chemical binding]; other site 410289003313 KR domain; Region: KR; pfam08659 410289003314 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 410289003315 putative NADP binding site [chemical binding]; other site 410289003316 active site 410289003317 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289003318 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 410289003319 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 410289003320 PE-PPE domain; Region: PE-PPE; pfam08237 410289003321 acyl-CoA synthetase; Validated; Region: PRK05850 410289003322 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 410289003323 acyl-activating enzyme (AAE) consensus motif; other site 410289003324 active site 410289003325 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 410289003326 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 410289003327 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 410289003328 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 410289003329 Glutamate binding site [chemical binding]; other site 410289003330 NAD binding site [chemical binding]; other site 410289003331 catalytic residues [active] 410289003332 Proline dehydrogenase; Region: Pro_dh; pfam01619 410289003333 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 410289003334 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 410289003335 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 410289003336 DNA binding residues [nucleotide binding] 410289003337 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 410289003338 N-RD18, 1548 bp. Region of Difference N-RD18, deleted region in Mycobacterium bovis BCG (position 1364204..1364205) Pasteur compared to Mycobacterium tuberculosis H37Rv2 (position: 1332921..1334468, 1548bp) and Mycobacterium bovis AF2122/97 (position 1334171..1335718). Removes gene Rv1190 and merges truncated genes Rv1189 and Rv1191 410289003339 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 410289003340 PGAP1-like protein; Region: PGAP1; pfam07819 410289003341 acyl-CoA synthetase; Validated; Region: PRK07787 410289003342 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289003343 acyl-activating enzyme (AAE) consensus motif; other site 410289003344 AMP binding site [chemical binding]; other site 410289003345 active site 410289003346 CoA binding site [chemical binding]; other site 410289003347 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 410289003348 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 410289003349 PE family; Region: PE; pfam00934 410289003350 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289003351 PPE family; Region: PPE; pfam00823 410289003352 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 410289003353 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 410289003354 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 410289003355 Transposase, Mutator family; Region: Transposase_mut; pfam00872 410289003356 MULE transposase domain; Region: MULE; pfam10551 410289003357 metabolite-proton symporter; Region: 2A0106; TIGR00883 410289003358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289003359 putative substrate translocation pore; other site 410289003360 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 410289003361 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 410289003362 putative trimer interface [polypeptide binding]; other site 410289003363 putative CoA binding site [chemical binding]; other site 410289003364 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 410289003365 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 410289003366 metal binding site [ion binding]; metal-binding site 410289003367 putative dimer interface [polypeptide binding]; other site 410289003368 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 410289003369 TIGR00730 family protein; Region: TIGR00730 410289003370 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 410289003371 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 410289003372 acyl-activating enzyme (AAE) consensus motif; other site 410289003373 putative AMP binding site [chemical binding]; other site 410289003374 putative active site [active] 410289003375 putative CoA binding site [chemical binding]; other site 410289003376 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 410289003377 dihydropteroate synthase; Region: DHPS; TIGR01496 410289003378 substrate binding pocket [chemical binding]; other site 410289003379 dimer interface [polypeptide binding]; other site 410289003380 inhibitor binding site; inhibition site 410289003381 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 410289003382 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 410289003383 DivIVA domain; Region: DivI1A_domain; TIGR03544 410289003384 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 410289003385 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 410289003386 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 410289003387 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 410289003388 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 410289003389 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 410289003390 ligand binding site; other site 410289003391 oligomer interface; other site 410289003392 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 410289003393 dimer interface [polypeptide binding]; other site 410289003394 N-terminal domain interface [polypeptide binding]; other site 410289003395 sulfate 1 binding site; other site 410289003396 PE family; Region: PE; pfam00934 410289003397 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 410289003398 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 410289003399 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 410289003400 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 410289003401 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 410289003402 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 410289003403 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 410289003404 Walker A/P-loop; other site 410289003405 ATP binding site [chemical binding]; other site 410289003406 Q-loop/lid; other site 410289003407 ABC transporter signature motif; other site 410289003408 Walker B; other site 410289003409 D-loop; other site 410289003410 H-loop/switch region; other site 410289003411 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 410289003412 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289003413 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 410289003414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289003415 S-adenosylmethionine binding site [chemical binding]; other site 410289003416 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 410289003417 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 410289003418 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 410289003419 DNA binding residues [nucleotide binding] 410289003420 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 410289003421 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 410289003422 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 410289003423 protein binding site [polypeptide binding]; other site 410289003424 sec-independent translocase; Provisional; Region: PRK03100 410289003425 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 410289003426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 410289003427 active site 410289003428 motif I; other site 410289003429 motif II; other site 410289003430 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 410289003431 Predicted membrane protein [Function unknown]; Region: COG3428 410289003432 Bacterial PH domain; Region: DUF304; pfam03703 410289003433 Uncharacterized conserved protein [Function unknown]; Region: COG3402 410289003434 Domain of unknown function DUF59; Region: DUF59; cl00941 410289003435 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 410289003436 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 410289003437 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 410289003438 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 410289003439 N-acetyl-D-glucosamine binding site [chemical binding]; other site 410289003440 catalytic residue [active] 410289003441 Predicted membrane protein [Function unknown]; Region: COG4420 410289003442 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 410289003443 MgtE intracellular N domain; Region: MgtE_N; smart00924 410289003444 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 410289003445 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 410289003446 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 410289003447 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 410289003448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289003449 dimer interface [polypeptide binding]; other site 410289003450 conserved gate region; other site 410289003451 putative PBP binding loops; other site 410289003452 ABC-ATPase subunit interface; other site 410289003453 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 410289003454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289003455 dimer interface [polypeptide binding]; other site 410289003456 conserved gate region; other site 410289003457 ABC-ATPase subunit interface; other site 410289003458 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 410289003459 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 410289003460 Walker A/P-loop; other site 410289003461 ATP binding site [chemical binding]; other site 410289003462 Q-loop/lid; other site 410289003463 ABC transporter signature motif; other site 410289003464 Walker B; other site 410289003465 D-loop; other site 410289003466 H-loop/switch region; other site 410289003467 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 410289003468 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 410289003469 oligomer interface [polypeptide binding]; other site 410289003470 metal binding site [ion binding]; metal-binding site 410289003471 metal binding site [ion binding]; metal-binding site 410289003472 putative Cl binding site [ion binding]; other site 410289003473 basic sphincter; other site 410289003474 hydrophobic gate; other site 410289003475 periplasmic entrance; other site 410289003476 malate dehydrogenase; Provisional; Region: PRK05442 410289003477 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 410289003478 NAD(P) binding site [chemical binding]; other site 410289003479 dimer interface [polypeptide binding]; other site 410289003480 malate binding site [chemical binding]; other site 410289003481 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 410289003482 PE family; Region: PE; pfam00934 410289003483 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 410289003484 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 410289003485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289003486 NAD(P) binding site [chemical binding]; other site 410289003487 active site 410289003488 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 410289003489 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 410289003490 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 410289003491 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 410289003492 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 410289003493 TPP-binding site [chemical binding]; other site 410289003494 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 410289003495 dimer interface [polypeptide binding]; other site 410289003496 PYR/PP interface [polypeptide binding]; other site 410289003497 TPP binding site [chemical binding]; other site 410289003498 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 410289003499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289003500 putative substrate translocation pore; other site 410289003501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289003502 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 410289003503 RNase_H superfamily; Region: RNase_H_2; pfam13482 410289003504 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 410289003505 Part of AAA domain; Region: AAA_19; pfam13245 410289003506 AAA domain; Region: AAA_12; pfam13087 410289003507 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 410289003508 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 410289003509 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 410289003510 ATP binding site [chemical binding]; other site 410289003511 Mg++ binding site [ion binding]; other site 410289003512 motif III; other site 410289003513 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 410289003514 nucleotide binding region [chemical binding]; other site 410289003515 ATP-binding site [chemical binding]; other site 410289003516 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 410289003517 putative RNA binding site [nucleotide binding]; other site 410289003518 Acyltransferase family; Region: Acyl_transf_3; pfam01757 410289003519 RD13, 3007 bp. Region of Difference RD13, deleted region in Mycobacterium bovis BCG Pasteur (position 1432652..1432653) and Mycobacterium bovis AF2122/97 (position 1404174..1404175) compared to Mycobacterium tuberculosis H37Rv2 (position: 1402931..1405937). Removes gene Rv1256c and merges truncated genes Rv1257c and Rv1255c 410289003520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289003521 H+ Antiporter protein; Region: 2A0121; TIGR00900 410289003522 putative substrate translocation pore; other site 410289003523 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 410289003524 Fe-S cluster binding site [ion binding]; other site 410289003525 DNA binding site [nucleotide binding] 410289003526 active site 410289003527 hypothetical protein; Provisional; Region: PRK07236 410289003528 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 410289003529 Domain of unknown function (DUF385); Region: DUF385; pfam04075 410289003530 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 410289003531 HIT family signature motif; other site 410289003532 catalytic residue [active] 410289003533 amidase; Provisional; Region: PRK12470 410289003534 Amidase; Region: Amidase; pfam01425 410289003535 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 410289003536 cyclase homology domain; Region: CHD; cd07302 410289003537 nucleotidyl binding site; other site 410289003538 metal binding site [ion binding]; metal-binding site 410289003539 dimer interface [polypeptide binding]; other site 410289003540 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 410289003541 Catalytic domain of Protein Kinases; Region: PKc; cd00180 410289003542 active site 410289003543 ATP binding site [chemical binding]; other site 410289003544 substrate binding site [chemical binding]; other site 410289003545 activation loop (A-loop); other site 410289003546 PknH-like extracellular domain; Region: PknH_C; pfam14032 410289003547 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 410289003548 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 410289003549 DNA binding site [nucleotide binding] 410289003550 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 410289003551 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 410289003552 phosphopeptide binding site; other site 410289003553 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 410289003554 putative active site [active] 410289003555 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 410289003556 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 410289003557 Protein of unknown function (DUF732); Region: DUF732; pfam05305 410289003558 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 410289003559 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 410289003560 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 410289003561 Walker A/P-loop; other site 410289003562 ATP binding site [chemical binding]; other site 410289003563 Q-loop/lid; other site 410289003564 ABC transporter signature motif; other site 410289003565 Walker B; other site 410289003566 D-loop; other site 410289003567 H-loop/switch region; other site 410289003568 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 410289003569 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 410289003570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289003571 Walker A/P-loop; other site 410289003572 ATP binding site [chemical binding]; other site 410289003573 Q-loop/lid; other site 410289003574 ABC transporter signature motif; other site 410289003575 Walker B; other site 410289003576 D-loop; other site 410289003577 H-loop/switch region; other site 410289003578 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 410289003579 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 410289003580 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 410289003581 catalytic core [active] 410289003582 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 410289003583 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 410289003584 active site 410289003585 metal binding site [ion binding]; metal-binding site 410289003586 DNA binding site [nucleotide binding] 410289003587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289003588 Walker A/P-loop; other site 410289003589 ATP binding site [chemical binding]; other site 410289003590 choline dehydrogenase; Validated; Region: PRK02106 410289003591 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 410289003592 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 410289003593 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 410289003594 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 410289003595 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 410289003596 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 410289003597 Walker A/P-loop; other site 410289003598 ATP binding site [chemical binding]; other site 410289003599 Q-loop/lid; other site 410289003600 ABC transporter signature motif; other site 410289003601 Walker B; other site 410289003602 D-loop; other site 410289003603 H-loop/switch region; other site 410289003604 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 410289003605 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 410289003606 Walker A/P-loop; other site 410289003607 ATP binding site [chemical binding]; other site 410289003608 Q-loop/lid; other site 410289003609 ABC transporter signature motif; other site 410289003610 Walker B; other site 410289003611 D-loop; other site 410289003612 H-loop/switch region; other site 410289003613 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 410289003614 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 410289003615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289003616 dimer interface [polypeptide binding]; other site 410289003617 conserved gate region; other site 410289003618 putative PBP binding loops; other site 410289003619 ABC-ATPase subunit interface; other site 410289003620 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 410289003621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289003622 dimer interface [polypeptide binding]; other site 410289003623 conserved gate region; other site 410289003624 putative PBP binding loops; other site 410289003625 ABC-ATPase subunit interface; other site 410289003626 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 410289003627 active site clefts [active] 410289003628 zinc binding site [ion binding]; other site 410289003629 dimer interface [polypeptide binding]; other site 410289003630 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 410289003631 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 410289003632 Active Sites [active] 410289003633 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 410289003634 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 410289003635 CysD dimerization site [polypeptide binding]; other site 410289003636 G1 box; other site 410289003637 putative GEF interaction site [polypeptide binding]; other site 410289003638 GTP/Mg2+ binding site [chemical binding]; other site 410289003639 Switch I region; other site 410289003640 G2 box; other site 410289003641 G3 box; other site 410289003642 Switch II region; other site 410289003643 G4 box; other site 410289003644 G5 box; other site 410289003645 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 410289003646 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 410289003647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289003648 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 410289003649 Walker A/P-loop; other site 410289003650 ligand-binding site [chemical binding]; other site 410289003651 ATP binding site [chemical binding]; other site 410289003652 Rrf2 family protein; Region: rrf2_super; TIGR00738 410289003653 Transcriptional regulator; Region: Rrf2; pfam02082 410289003654 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 410289003655 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 410289003656 Putative esterase; Region: Esterase; pfam00756 410289003657 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 410289003658 Predicted membrane protein [Function unknown]; Region: COG4325 410289003659 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 410289003660 Protein of unknown function (DUF732); Region: DUF732; pfam05305 410289003661 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 410289003662 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 410289003663 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 410289003664 active site 410289003665 HIGH motif; other site 410289003666 KMSK motif region; other site 410289003667 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 410289003668 tRNA binding surface [nucleotide binding]; other site 410289003669 anticodon binding site; other site 410289003670 diaminopimelate decarboxylase; Region: lysA; TIGR01048 410289003671 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 410289003672 active site 410289003673 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 410289003674 substrate binding site [chemical binding]; other site 410289003675 catalytic residues [active] 410289003676 dimer interface [polypeptide binding]; other site 410289003677 homoserine dehydrogenase; Provisional; Region: PRK06349 410289003678 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 410289003679 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 410289003680 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 410289003681 threonine synthase; Reviewed; Region: PRK06721 410289003682 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 410289003683 homodimer interface [polypeptide binding]; other site 410289003684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289003685 catalytic residue [active] 410289003686 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 410289003687 transcription termination factor Rho; Provisional; Region: PRK12678 410289003688 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 410289003689 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 410289003690 RNA binding site [nucleotide binding]; other site 410289003691 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 410289003692 multimer interface [polypeptide binding]; other site 410289003693 Walker A motif; other site 410289003694 ATP binding site [chemical binding]; other site 410289003695 Walker B motif; other site 410289003696 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 410289003697 peptide chain release factor 1; Region: prfA; TIGR00019 410289003698 This domain is found in peptide chain release factors; Region: PCRF; smart00937 410289003699 RF-1 domain; Region: RF-1; pfam00472 410289003700 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 410289003701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289003702 S-adenosylmethionine binding site [chemical binding]; other site 410289003703 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 410289003704 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 410289003705 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 410289003706 Mg++ binding site [ion binding]; other site 410289003707 putative catalytic motif [active] 410289003708 substrate binding site [chemical binding]; other site 410289003709 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 410289003710 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 410289003711 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 410289003712 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 410289003713 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 410289003714 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 410289003715 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 410289003716 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 410289003717 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 410289003718 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 410289003719 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 410289003720 Walker A motif; other site 410289003721 ATP binding site [chemical binding]; other site 410289003722 Walker B motif; other site 410289003723 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 410289003724 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 410289003725 core domain interface [polypeptide binding]; other site 410289003726 delta subunit interface [polypeptide binding]; other site 410289003727 epsilon subunit interface [polypeptide binding]; other site 410289003728 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 410289003729 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 410289003730 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 410289003731 alpha subunit interaction interface [polypeptide binding]; other site 410289003732 Walker A motif; other site 410289003733 ATP binding site [chemical binding]; other site 410289003734 Walker B motif; other site 410289003735 inhibitor binding site; inhibition site 410289003736 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 410289003737 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 410289003738 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 410289003739 gamma subunit interface [polypeptide binding]; other site 410289003740 epsilon subunit interface [polypeptide binding]; other site 410289003741 LBP interface [polypeptide binding]; other site 410289003742 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 410289003743 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 410289003744 Transposase; Region: DDE_Tnp_ISL3; pfam01610 410289003745 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 410289003746 Transposase; Region: DDE_Tnp_ISL3; pfam01610 410289003747 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 410289003748 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 410289003749 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 410289003750 hinge; other site 410289003751 active site 410289003752 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 410289003753 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 410289003754 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 410289003755 DNA binding site [nucleotide binding] 410289003756 active site 410289003757 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 410289003758 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 410289003759 AlkA N-terminal domain; Region: AlkA_N; pfam06029 410289003760 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 410289003761 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 410289003762 minor groove reading motif; other site 410289003763 helix-hairpin-helix signature motif; other site 410289003764 substrate binding pocket [chemical binding]; other site 410289003765 active site 410289003766 HAMP domain; Region: HAMP; pfam00672 410289003767 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 410289003768 cyclase homology domain; Region: CHD; cd07302 410289003769 nucleotidyl binding site; other site 410289003770 metal binding site [ion binding]; metal-binding site 410289003771 dimer interface [polypeptide binding]; other site 410289003772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 410289003773 dimerization interface [polypeptide binding]; other site 410289003774 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 410289003775 cyclase homology domain; Region: CHD; cd07302 410289003776 nucleotidyl binding site; other site 410289003777 metal binding site [ion binding]; metal-binding site 410289003778 dimer interface [polypeptide binding]; other site 410289003779 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 410289003780 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 410289003781 dimerization interface [polypeptide binding]; other site 410289003782 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 410289003783 cyclase homology domain; Region: CHD; cd07302 410289003784 nucleotidyl binding site; other site 410289003785 metal binding site [ion binding]; metal-binding site 410289003786 dimer interface [polypeptide binding]; other site 410289003787 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 410289003788 hypothetical protein; Provisional; Region: PRK03298 410289003789 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 410289003790 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 410289003791 dimer interface [polypeptide binding]; other site 410289003792 substrate binding site [chemical binding]; other site 410289003793 metal binding site [ion binding]; metal-binding site 410289003794 putative acyltransferase; Provisional; Region: PRK05790 410289003795 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 410289003796 dimer interface [polypeptide binding]; other site 410289003797 active site 410289003798 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 410289003799 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 410289003800 PE family; Region: PE; pfam00934 410289003801 glycogen branching enzyme; Provisional; Region: PRK05402 410289003802 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 410289003803 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 410289003804 active site 410289003805 catalytic site [active] 410289003806 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 410289003807 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 410289003808 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 410289003809 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 410289003810 active site 410289003811 homodimer interface [polypeptide binding]; other site 410289003812 catalytic site [active] 410289003813 acceptor binding site [chemical binding]; other site 410289003814 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 410289003815 putative homodimer interface [polypeptide binding]; other site 410289003816 putative active site pocket [active] 410289003817 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 410289003818 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 410289003819 DEAD/DEAH box helicase; Region: DEAD; pfam00270 410289003820 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 410289003821 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 410289003822 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 410289003823 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 410289003824 active site 410289003825 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 410289003826 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 410289003827 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 410289003828 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 410289003829 putative active site pocket [active] 410289003830 cleavage site 410289003831 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 410289003832 MPN+ (JAMM) motif; other site 410289003833 Zinc-binding site [ion binding]; other site 410289003834 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 410289003835 MoaE interaction surface [polypeptide binding]; other site 410289003836 MoeB interaction surface [polypeptide binding]; other site 410289003837 thiocarboxylated glycine; other site 410289003838 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 410289003839 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 410289003840 dimer interface [polypeptide binding]; other site 410289003841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289003842 catalytic residue [active] 410289003843 Rhomboid family; Region: Rhomboid; pfam01694 410289003844 glutamate racemase; Provisional; Region: PRK00865 410289003845 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 410289003846 ribonuclease PH; Reviewed; Region: rph; PRK00173 410289003847 Ribonuclease PH; Region: RNase_PH_bact; cd11362 410289003848 hexamer interface [polypeptide binding]; other site 410289003849 active site 410289003850 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 410289003851 active site 410289003852 dimerization interface [polypeptide binding]; other site 410289003853 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 410289003854 Glucitol operon activator [Transcription]; Region: GutM; COG4578 410289003855 acyl carrier protein; Validated; Region: PRK05883 410289003856 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 410289003857 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 410289003858 acyl-activating enzyme (AAE) consensus motif; other site 410289003859 active site 410289003860 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289003861 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289003862 active site 410289003863 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 410289003864 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 410289003865 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 410289003866 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 410289003867 FAD binding pocket [chemical binding]; other site 410289003868 FAD binding motif [chemical binding]; other site 410289003869 phosphate binding motif [ion binding]; other site 410289003870 NAD binding pocket [chemical binding]; other site 410289003871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289003872 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 410289003873 Walker A/P-loop; other site 410289003874 ATP binding site [chemical binding]; other site 410289003875 Q-loop/lid; other site 410289003876 ABC transporter signature motif; other site 410289003877 Walker B; other site 410289003878 D-loop; other site 410289003879 H-loop/switch region; other site 410289003880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289003881 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 410289003882 Walker A/P-loop; other site 410289003883 ATP binding site [chemical binding]; other site 410289003884 Q-loop/lid; other site 410289003885 ABC transporter signature motif; other site 410289003886 Walker B; other site 410289003887 D-loop; other site 410289003888 H-loop/switch region; other site 410289003889 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 410289003890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289003891 NAD(P) binding site [chemical binding]; other site 410289003892 active site 410289003893 tetracycline repressor protein TetR; Provisional; Region: PRK13756 410289003894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289003895 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 410289003896 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 410289003897 GAF domain; Region: GAF; pfam01590 410289003898 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 410289003899 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 410289003900 metal binding site [ion binding]; metal-binding site 410289003901 active site 410289003902 I-site; other site 410289003903 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 410289003904 hypothetical protein; Provisional; Region: PRK07877 410289003905 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 410289003906 ATP binding site [chemical binding]; other site 410289003907 substrate interface [chemical binding]; other site 410289003908 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 410289003909 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 410289003910 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 410289003911 cyclase homology domain; Region: CHD; cd07302 410289003912 nucleotidyl binding site; other site 410289003913 dimer interface [polypeptide binding]; other site 410289003914 metal binding site [ion binding]; metal-binding site 410289003915 AAA ATPase domain; Region: AAA_16; pfam13191 410289003916 Predicted ATPase [General function prediction only]; Region: COG3903 410289003917 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 410289003918 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 410289003919 DNA binding residues [nucleotide binding] 410289003920 dimerization interface [polypeptide binding]; other site 410289003921 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 410289003922 cyclase homology domain; Region: CHD; cd07302 410289003923 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 410289003924 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 410289003925 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289003926 PPE family; Region: PPE; pfam00823 410289003927 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 410289003928 PAS fold; Region: PAS_4; pfam08448 410289003929 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 410289003930 putative active site [active] 410289003931 heme pocket [chemical binding]; other site 410289003932 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 410289003933 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 410289003934 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 410289003935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 410289003936 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 410289003937 anti sigma factor interaction site; other site 410289003938 regulatory phosphorylation site [posttranslational modification]; other site 410289003939 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 410289003940 anti sigma factor interaction site; other site 410289003941 regulatory phosphorylation site [posttranslational modification]; other site 410289003942 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 410289003943 synthetase active site [active] 410289003944 NTP binding site [chemical binding]; other site 410289003945 metal binding site [ion binding]; metal-binding site 410289003946 Beta-lactamase; Region: Beta-lactamase; pfam00144 410289003947 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 410289003948 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 410289003949 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 410289003950 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 410289003951 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 410289003952 putative di-iron ligands [ion binding]; other site 410289003953 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 410289003954 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 410289003955 malonyl-CoA binding site [chemical binding]; other site 410289003956 dimer interface [polypeptide binding]; other site 410289003957 active site 410289003958 product binding site; other site 410289003959 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 410289003960 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 410289003961 uncharacterized domain; Region: TIGR00702 410289003962 YcaO-like family; Region: YcaO; pfam02624 410289003963 Uncharacterized conserved protein [Function unknown]; Region: COG3482 410289003964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289003965 S-adenosylmethionine binding site [chemical binding]; other site 410289003966 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289003967 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289003968 active site 410289003969 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 410289003970 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 410289003971 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 410289003972 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 410289003973 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 410289003974 dihydroorotase; Validated; Region: pyrC; PRK09357 410289003975 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 410289003976 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 410289003977 active site 410289003978 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 410289003979 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 410289003980 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 410289003981 catalytic site [active] 410289003982 subunit interface [polypeptide binding]; other site 410289003983 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 410289003984 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 410289003985 ATP-grasp domain; Region: ATP-grasp_4; cl17255 410289003986 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 410289003987 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 410289003988 ATP-grasp domain; Region: ATP-grasp_4; cl17255 410289003989 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 410289003990 IMP binding site; other site 410289003991 dimer interface [polypeptide binding]; other site 410289003992 interdomain contacts; other site 410289003993 partial ornithine binding site; other site 410289003994 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 410289003995 active site 410289003996 dimer interface [polypeptide binding]; other site 410289003997 PE family; Region: PE; pfam00934 410289003998 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289003999 PPE family; Region: PPE; pfam00823 410289004000 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 410289004001 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 410289004002 catalytic site [active] 410289004003 G-X2-G-X-G-K; other site 410289004004 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 410289004005 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 410289004006 Flavoprotein; Region: Flavoprotein; pfam02441 410289004007 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 410289004008 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 410289004009 S-adenosylmethionine synthetase; Validated; Region: PRK05250 410289004010 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 410289004011 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 410289004012 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 410289004013 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 410289004014 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289004015 Cytochrome P450; Region: p450; cl12078 410289004016 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 410289004017 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 410289004018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 410289004019 PE family; Region: PE; pfam00934 410289004020 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 410289004021 oligomeric interface; other site 410289004022 putative active site [active] 410289004023 homodimer interface [polypeptide binding]; other site 410289004024 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 410289004025 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 410289004026 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 410289004027 substrate binding pocket [chemical binding]; other site 410289004028 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 410289004029 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 410289004030 substrate binding pocket [chemical binding]; other site 410289004031 Predicted membrane protein [Function unknown]; Region: COG3714 410289004032 primosome assembly protein PriA; Provisional; Region: PRK14873 410289004033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289004034 S-adenosylmethionine binding site [chemical binding]; other site 410289004035 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 410289004036 MarR family; Region: MarR; pfam01047 410289004037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289004038 S-adenosylmethionine binding site [chemical binding]; other site 410289004039 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 410289004040 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 410289004041 putative active site [active] 410289004042 substrate binding site [chemical binding]; other site 410289004043 putative cosubstrate binding site; other site 410289004044 catalytic site [active] 410289004045 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 410289004046 substrate binding site [chemical binding]; other site 410289004047 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 410289004048 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 410289004049 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 410289004050 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 410289004051 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 410289004052 substrate binding site [chemical binding]; other site 410289004053 hexamer interface [polypeptide binding]; other site 410289004054 metal binding site [ion binding]; metal-binding site 410289004055 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 410289004056 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 410289004057 catalytic motif [active] 410289004058 Zn binding site [ion binding]; other site 410289004059 RibD C-terminal domain; Region: RibD_C; pfam01872 410289004060 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 410289004061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289004062 putative substrate translocation pore; other site 410289004063 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 410289004064 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 410289004065 Lumazine binding domain; Region: Lum_binding; pfam00677 410289004066 Lumazine binding domain; Region: Lum_binding; pfam00677 410289004067 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 410289004068 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 410289004069 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 410289004070 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 410289004071 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 410289004072 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 410289004073 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 410289004074 dimerization interface [polypeptide binding]; other site 410289004075 active site 410289004076 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 410289004077 homopentamer interface [polypeptide binding]; other site 410289004078 active site 410289004079 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 410289004080 PknH-like extracellular domain; Region: PknH_C; pfam14032 410289004081 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 410289004082 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 410289004083 putative sugar binding sites [chemical binding]; other site 410289004084 Q-X-W motif; other site 410289004085 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 410289004086 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 410289004087 GIY-YIG motif/motif A; other site 410289004088 active site 410289004089 catalytic site [active] 410289004090 putative DNA binding site [nucleotide binding]; other site 410289004091 metal binding site [ion binding]; metal-binding site 410289004092 UvrB/uvrC motif; Region: UVR; pfam02151 410289004093 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 410289004094 Helix-hairpin-helix motif; Region: HHH; pfam00633 410289004095 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 410289004096 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 410289004097 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 410289004098 phosphate binding site [ion binding]; other site 410289004099 putative substrate binding pocket [chemical binding]; other site 410289004100 dimer interface [polypeptide binding]; other site 410289004101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 410289004102 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 410289004103 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 410289004104 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 410289004105 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 410289004106 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 410289004107 acyl-CoA synthetase; Provisional; Region: PRK13382 410289004108 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 410289004109 acyl-activating enzyme (AAE) consensus motif; other site 410289004110 putative AMP binding site [chemical binding]; other site 410289004111 putative active site [active] 410289004112 putative CoA binding site [chemical binding]; other site 410289004113 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 410289004114 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 410289004115 putative acyl-acceptor binding pocket; other site 410289004116 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 410289004117 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 410289004118 PE family; Region: PE; pfam00934 410289004119 PE-PPE domain; Region: PE-PPE; pfam08237 410289004120 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 410289004121 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 410289004122 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 410289004123 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 410289004124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 410289004125 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 410289004126 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 410289004127 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 410289004128 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 410289004129 Phosphoglycerate kinase; Region: PGK; pfam00162 410289004130 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 410289004131 substrate binding site [chemical binding]; other site 410289004132 hinge regions; other site 410289004133 ADP binding site [chemical binding]; other site 410289004134 catalytic site [active] 410289004135 triosephosphate isomerase; Provisional; Region: PRK14567 410289004136 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 410289004137 substrate binding site [chemical binding]; other site 410289004138 dimer interface [polypeptide binding]; other site 410289004139 catalytic triad [active] 410289004140 SnoaL-like domain; Region: SnoaL_2; pfam12680 410289004141 Preprotein translocase SecG subunit; Region: SecG; cl09123 410289004142 PE family; Region: PE; pfam00934 410289004143 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 410289004144 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 410289004145 molybdopterin cofactor binding site [chemical binding]; other site 410289004146 substrate binding site [chemical binding]; other site 410289004147 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 410289004148 molybdopterin cofactor binding site; other site 410289004149 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 410289004150 hydrophobic ligand binding site; other site 410289004151 Proteins of 100 residues with WXG; Region: WXG100; cl02005 410289004152 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 410289004153 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 410289004154 putative active site [active] 410289004155 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 410289004156 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 410289004157 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 410289004158 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 410289004159 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 410289004160 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 410289004161 putative active site [active] 410289004162 transaldolase; Provisional; Region: PRK03903 410289004163 catalytic residue [active] 410289004164 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 410289004165 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 410289004166 TPP-binding site [chemical binding]; other site 410289004167 dimer interface [polypeptide binding]; other site 410289004168 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 410289004169 PYR/PP interface [polypeptide binding]; other site 410289004170 dimer interface [polypeptide binding]; other site 410289004171 TPP binding site [chemical binding]; other site 410289004172 PE family; Region: PE; pfam00934 410289004173 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 410289004174 UbiA prenyltransferase family; Region: UbiA; pfam01040 410289004175 PE family; Region: PE; pfam00934 410289004176 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 410289004177 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 410289004178 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 410289004179 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 410289004180 NADP binding site [chemical binding]; other site 410289004181 dimer interface [polypeptide binding]; other site 410289004182 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 410289004183 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 410289004184 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 410289004185 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 410289004186 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 410289004187 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 410289004188 Walker A/P-loop; other site 410289004189 ATP binding site [chemical binding]; other site 410289004190 Q-loop/lid; other site 410289004191 ABC transporter signature motif; other site 410289004192 Walker B; other site 410289004193 D-loop; other site 410289004194 H-loop/switch region; other site 410289004195 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 410289004196 Predicted transcriptional regulator [Transcription]; Region: COG2345 410289004197 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 410289004198 putative DNA binding site [nucleotide binding]; other site 410289004199 putative Zn2+ binding site [ion binding]; other site 410289004200 Transcriptional regulator PadR-like family; Region: PadR; cl17335 410289004201 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 410289004202 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 410289004203 protein-splicing catalytic site; other site 410289004204 thioester formation/cholesterol transfer; other site 410289004205 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 410289004206 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 410289004207 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 410289004208 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 410289004209 FeS assembly protein SufD; Region: sufD; TIGR01981 410289004210 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 410289004211 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 410289004212 Walker A/P-loop; other site 410289004213 ATP binding site [chemical binding]; other site 410289004214 Q-loop/lid; other site 410289004215 ABC transporter signature motif; other site 410289004216 Walker B; other site 410289004217 D-loop; other site 410289004218 H-loop/switch region; other site 410289004219 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 410289004220 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 410289004221 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 410289004222 catalytic residue [active] 410289004223 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 410289004224 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 410289004225 trimerization site [polypeptide binding]; other site 410289004226 active site 410289004227 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 410289004228 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 410289004229 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 410289004230 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289004231 active site 410289004232 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 410289004233 PE family; Region: PE; pfam00934 410289004234 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 410289004235 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 410289004236 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 410289004237 catalytic residues [active] 410289004238 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 410289004239 catalytic residues [active] 410289004240 enoyl-CoA hydratase; Provisional; Region: PRK05864 410289004241 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289004242 substrate binding site [chemical binding]; other site 410289004243 oxyanion hole (OAH) forming residues; other site 410289004244 trimer interface [polypeptide binding]; other site 410289004245 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 410289004246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289004247 Walker A/P-loop; other site 410289004248 ATP binding site [chemical binding]; other site 410289004249 Q-loop/lid; other site 410289004250 ABC transporter signature motif; other site 410289004251 Walker B; other site 410289004252 D-loop; other site 410289004253 H-loop/switch region; other site 410289004254 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 410289004255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289004256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289004257 aconitate hydratase; Validated; Region: PRK09277 410289004258 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 410289004259 substrate binding site [chemical binding]; other site 410289004260 ligand binding site [chemical binding]; other site 410289004261 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 410289004262 substrate binding site [chemical binding]; other site 410289004263 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 410289004264 NlpC/P60 family; Region: NLPC_P60; pfam00877 410289004265 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 410289004266 NlpC/P60 family; Region: NLPC_P60; pfam00877 410289004267 MoxR-like ATPases [General function prediction only]; Region: COG0714 410289004268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289004269 Walker A motif; other site 410289004270 ATP binding site [chemical binding]; other site 410289004271 Walker B motif; other site 410289004272 arginine finger; other site 410289004273 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 410289004274 Protein of unknown function DUF58; Region: DUF58; pfam01882 410289004275 hypothetical protein; Provisional; Region: PRK13685 410289004276 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 410289004277 metal ion-dependent adhesion site (MIDAS); other site 410289004278 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 410289004279 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 410289004280 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 410289004281 NAD(P) binding site [chemical binding]; other site 410289004282 homotetramer interface [polypeptide binding]; other site 410289004283 homodimer interface [polypeptide binding]; other site 410289004284 active site 410289004285 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 410289004286 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 410289004287 NAD binding site [chemical binding]; other site 410289004288 homotetramer interface [polypeptide binding]; other site 410289004289 homodimer interface [polypeptide binding]; other site 410289004290 substrate binding site [chemical binding]; other site 410289004291 active site 410289004292 ferrochelatase; Reviewed; Region: hemH; PRK00035 410289004293 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 410289004294 C-terminal domain interface [polypeptide binding]; other site 410289004295 active site 410289004296 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 410289004297 active site 410289004298 N-terminal domain interface [polypeptide binding]; other site 410289004299 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 410289004300 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 410289004301 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 410289004302 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 410289004303 Uncharacterized conserved protein [Function unknown]; Region: COG0398 410289004304 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 410289004305 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 410289004306 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 410289004307 heterodimer interface [polypeptide binding]; other site 410289004308 substrate interaction site [chemical binding]; other site 410289004309 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 410289004310 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 410289004311 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 410289004312 active site 410289004313 substrate binding site [chemical binding]; other site 410289004314 coenzyme B12 binding site [chemical binding]; other site 410289004315 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 410289004316 B12 binding site [chemical binding]; other site 410289004317 cobalt ligand [ion binding]; other site 410289004318 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 410289004319 membrane ATPase/protein kinase; Provisional; Region: PRK09435 410289004320 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 410289004321 Walker A; other site 410289004322 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 410289004323 Beta-lactamase; Region: Beta-lactamase; pfam00144 410289004324 Methyltransferase domain; Region: Methyltransf_31; pfam13847 410289004325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289004326 S-adenosylmethionine binding site [chemical binding]; other site 410289004327 Dodecin; Region: Dodecin; pfam07311 410289004328 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 410289004329 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 410289004330 Ligand binding site; other site 410289004331 Putative Catalytic site; other site 410289004332 DXD motif; other site 410289004333 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 410289004334 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 410289004335 active site 410289004336 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 410289004337 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 410289004338 inhibitor-cofactor binding pocket; inhibition site 410289004339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289004340 catalytic residue [active] 410289004341 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 410289004342 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 410289004343 putative trimer interface [polypeptide binding]; other site 410289004344 putative CoA binding site [chemical binding]; other site 410289004345 RD4, 12732 bp. Region of Difference RD4, deleted region in Mycobacterium bovis BCG Pasteur (position 1721089-1721090) and Mycobacterium bovis AF2122/97 (position 1692761..1692762) compared to Mycobacterium tuberculosis H37Rv2 (position: 1696017..1708748). Removes genes Rv1506-Rv1516 410289004346 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 410289004347 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 410289004348 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 410289004349 active site 410289004350 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 410289004351 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 410289004352 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 410289004353 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 410289004354 active site 410289004355 acyl-CoA synthetase; Validated; Region: PRK05850 410289004356 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 410289004357 acyl-activating enzyme (AAE) consensus motif; other site 410289004358 active site 410289004359 Transport protein; Region: actII; TIGR00833 410289004360 Methyltransferase domain; Region: Methyltransf_23; pfam13489 410289004361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289004362 S-adenosylmethionine binding site [chemical binding]; other site 410289004363 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 410289004364 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 410289004365 homodimer interface [polypeptide binding]; other site 410289004366 active site 410289004367 TDP-binding site; other site 410289004368 acceptor substrate-binding pocket; other site 410289004369 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 410289004370 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 410289004371 Probable Catalytic site; other site 410289004372 metal-binding site 410289004373 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 410289004374 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 410289004375 homodimer interface [polypeptide binding]; other site 410289004376 active site 410289004377 TDP-binding site; other site 410289004378 acceptor substrate-binding pocket; other site 410289004379 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 410289004380 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289004381 active site 410289004382 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 410289004383 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 410289004384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289004385 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 410289004386 Enoylreductase; Region: PKS_ER; smart00829 410289004387 NAD(P) binding site [chemical binding]; other site 410289004388 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 410289004389 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 410289004390 putative NADP binding site [chemical binding]; other site 410289004391 active site 410289004392 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289004393 acyl-CoA synthetase; Validated; Region: PRK05850 410289004394 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 410289004395 acyl-activating enzyme (AAE) consensus motif; other site 410289004396 active site 410289004397 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 410289004398 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 410289004399 NAD(P) binding site [chemical binding]; other site 410289004400 Uncharacterized conserved protein [Function unknown]; Region: COG2128 410289004401 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 410289004402 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 410289004403 CoenzymeA binding site [chemical binding]; other site 410289004404 subunit interaction site [polypeptide binding]; other site 410289004405 PHB binding site; other site 410289004406 Nitronate monooxygenase; Region: NMO; pfam03060 410289004407 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 410289004408 FMN binding site [chemical binding]; other site 410289004409 substrate binding site [chemical binding]; other site 410289004410 putative catalytic residue [active] 410289004411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289004412 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 410289004413 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 410289004414 HIGH motif; other site 410289004415 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 410289004416 active site 410289004417 KMSKS motif; other site 410289004418 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 410289004419 tRNA binding surface [nucleotide binding]; other site 410289004420 anticodon binding site; other site 410289004421 DNA polymerase IV; Provisional; Region: PRK03348 410289004422 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 410289004423 active site 410289004424 DNA binding site [nucleotide binding] 410289004425 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 410289004426 active site 410289004427 homodimer interface [polypeptide binding]; other site 410289004428 homotetramer interface [polypeptide binding]; other site 410289004429 lipoprotein signal peptidase; Provisional; Region: PRK14764 410289004430 lipoprotein signal peptidase; Provisional; Region: PRK14787 410289004431 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 410289004432 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 410289004433 active site 410289004434 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 410289004435 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 410289004436 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 410289004437 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 410289004438 apolar tunnel; other site 410289004439 heme binding site [chemical binding]; other site 410289004440 dimerization interface [polypeptide binding]; other site 410289004441 short chain dehydrogenase; Provisional; Region: PRK05866 410289004442 classical (c) SDRs; Region: SDR_c; cd05233 410289004443 NAD(P) binding site [chemical binding]; other site 410289004444 active site 410289004445 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 410289004446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289004447 NAD(P) binding site [chemical binding]; other site 410289004448 active site 410289004449 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 410289004450 hydrophobic ligand binding site; other site 410289004451 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 410289004452 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 410289004453 active site 410289004454 PHP Thumb interface [polypeptide binding]; other site 410289004455 metal binding site [ion binding]; metal-binding site 410289004456 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 410289004457 generic binding surface II; other site 410289004458 generic binding surface I; other site 410289004459 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289004460 PPE family; Region: PPE; pfam00823 410289004461 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289004462 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289004463 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 410289004464 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 410289004465 acyl-activating enzyme (AAE) consensus motif; other site 410289004466 putative AMP binding site [chemical binding]; other site 410289004467 putative active site [active] 410289004468 putative CoA binding site [chemical binding]; other site 410289004469 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 410289004470 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 410289004471 putative acyl-acceptor binding pocket; other site 410289004472 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 410289004473 L-aspartate oxidase; Provisional; Region: PRK06175 410289004474 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 410289004475 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 410289004476 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 410289004477 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 410289004478 D-subunit interface [polypeptide binding]; other site 410289004479 Iron-sulfur protein interface; other site 410289004480 proximal quinone binding site [chemical binding]; other site 410289004481 distal quinone binding site [chemical binding]; other site 410289004482 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 410289004483 Iron-sulfur protein interface; other site 410289004484 proximal quinone binding site [chemical binding]; other site 410289004485 C-subunit interface; other site 410289004486 distal quinone binding site; other site 410289004487 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289004488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289004489 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 410289004490 TbD1, 2153 bp. Region of Difference TbD1, inserted region in Mycobacterium bovis BCG Pasteur (position 1774132..1776284, 2153bp) and Mycobacterium bovis AF2122/97 (position 1745809..1747961, 2153bp) compared to Mycobacterium tuberculosis H37Rv2 (position: 1761789..1761790). This deletion in Mycobacterium tuberculosis modern strains,e.g. H37Rv, merges truncated genes mmpS6 and mmpL6 in an uniq gene, mmpL6 (Rv1557) 410289004491 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 410289004492 Domain of unknown function (DUF385); Region: DUF385; pfam04075 410289004493 threonine dehydratase; Validated; Region: PRK08639 410289004494 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 410289004495 tetramer interface [polypeptide binding]; other site 410289004496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289004497 catalytic residue [active] 410289004498 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 410289004499 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 410289004500 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 410289004501 putative active site [active] 410289004502 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 410289004503 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 410289004504 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 410289004505 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 410289004506 catalytic site [active] 410289004507 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 410289004508 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 410289004509 active site 410289004510 catalytic site [active] 410289004511 RD17, 806bp. Region of Difference RD17, deleted region in Mycobacterium bovis AF2122/97 (position: 1754245..1754246) compared to Mycobacterium tuberculosis H37Rv2 (position: 1768074..1768879, 806bp) and Mycobacterium bovis BCG Pasteur (position: 1782568..1783373, 806bp). This deletion, in Mycobacterium bovis AF2122/97, splits treY in 2 genes treYa and treYb 410289004512 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 410289004513 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 410289004514 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 410289004515 active site 410289004516 catalytic site [active] 410289004517 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 410289004518 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 410289004519 NlpC/P60 family; Region: NLPC_P60; pfam00877 410289004520 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 410289004521 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 410289004522 inhibitor-cofactor binding pocket; inhibition site 410289004523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289004524 catalytic residue [active] 410289004525 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 410289004526 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 410289004527 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 410289004528 catalytic residue [active] 410289004529 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 410289004530 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 410289004531 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289004532 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289004533 active site 410289004534 RD3, 9247 bp. Region of Difference RD3 (phiRv1), deleted region in Mycobacterium bovis BCG Pasteur (position 1793772..1793773) compared to Mycobacterium tuberculosis H37Rv2 (position: 1779279..1788525) and Mycobacterium bovis AF2122/97 (position 1764645..1773891). Removes genes Rv1573c-Rv1586c and merges truncated genes Rv1587c and Rv1572c 410289004535 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289004536 biotin synthase; Validated; Region: PRK06256 410289004537 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 410289004538 FeS/SAM binding site; other site 410289004539 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 410289004540 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 410289004541 Secretory lipase; Region: LIP; pfam03583 410289004542 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 410289004543 nudix motif; other site 410289004544 quinolinate synthetase; Provisional; Region: PRK09375 410289004545 L-aspartate oxidase; Provisional; Region: PRK07804 410289004546 L-aspartate oxidase; Provisional; Region: PRK06175 410289004547 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 410289004548 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 410289004549 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 410289004550 dimerization interface [polypeptide binding]; other site 410289004551 active site 410289004552 Methyltransferase domain; Region: Methyltransf_11; pfam08241 410289004553 S-adenosylmethionine binding site [chemical binding]; other site 410289004554 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 410289004555 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 410289004556 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 410289004557 NAD binding site [chemical binding]; other site 410289004558 dimerization interface [polypeptide binding]; other site 410289004559 product binding site; other site 410289004560 substrate binding site [chemical binding]; other site 410289004561 zinc binding site [ion binding]; other site 410289004562 catalytic residues [active] 410289004563 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 410289004564 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 410289004565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289004566 homodimer interface [polypeptide binding]; other site 410289004567 catalytic residue [active] 410289004568 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 410289004569 4-fold oligomerization interface [polypeptide binding]; other site 410289004570 putative active site pocket [active] 410289004571 metal binding residues [ion binding]; metal-binding site 410289004572 3-fold/trimer interface [polypeptide binding]; other site 410289004573 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 410289004574 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 410289004575 putative active site [active] 410289004576 oxyanion strand; other site 410289004577 catalytic triad [active] 410289004578 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 410289004579 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 410289004580 catalytic residues [active] 410289004581 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 410289004582 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 410289004583 active site 410289004584 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 410289004585 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 410289004586 substrate binding site [chemical binding]; other site 410289004587 glutamase interaction surface [polypeptide binding]; other site 410289004588 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 410289004589 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 410289004590 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 410289004591 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 410289004592 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 410289004593 catalytic triad [active] 410289004594 anthranilate synthase component I; Provisional; Region: PRK13571 410289004595 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 410289004596 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 410289004597 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 410289004598 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 410289004599 active site 410289004600 ribulose/triose binding site [chemical binding]; other site 410289004601 phosphate binding site [ion binding]; other site 410289004602 substrate (anthranilate) binding pocket [chemical binding]; other site 410289004603 product (indole) binding pocket [chemical binding]; other site 410289004604 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 410289004605 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 410289004606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289004607 catalytic residue [active] 410289004608 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 410289004609 substrate binding site [chemical binding]; other site 410289004610 active site 410289004611 catalytic residues [active] 410289004612 heterodimer interface [polypeptide binding]; other site 410289004613 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 410289004614 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 410289004615 TM2 domain; Region: TM2; pfam05154 410289004616 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 410289004617 pyruvate kinase; Provisional; Region: PRK06247 410289004618 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 410289004619 domain interfaces; other site 410289004620 active site 410289004621 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 410289004622 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 410289004623 active site 410289004624 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 410289004625 catalytic triad [active] 410289004626 dimer interface [polypeptide binding]; other site 410289004627 Uncharacterized conserved protein [Function unknown]; Region: COG2898 410289004628 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 410289004629 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 410289004630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289004631 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 410289004632 Walker A/P-loop; other site 410289004633 Walker A/P-loop; other site 410289004634 ATP binding site [chemical binding]; other site 410289004635 ATP binding site [chemical binding]; other site 410289004636 Q-loop/lid; other site 410289004637 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 410289004638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289004639 Walker A/P-loop; other site 410289004640 ATP binding site [chemical binding]; other site 410289004641 Q-loop/lid; other site 410289004642 ABC transporter signature motif; other site 410289004643 Walker B; other site 410289004644 D-loop; other site 410289004645 H-loop/switch region; other site 410289004646 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 410289004647 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 410289004648 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 410289004649 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 410289004650 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 410289004651 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 410289004652 cyclase homology domain; Region: CHD; cd07302 410289004653 nucleotidyl binding site; other site 410289004654 metal binding site [ion binding]; metal-binding site 410289004655 dimer interface [polypeptide binding]; other site 410289004656 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 410289004657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 410289004658 active site 410289004659 phosphorylation site [posttranslational modification] 410289004660 intermolecular recognition site; other site 410289004661 dimerization interface [polypeptide binding]; other site 410289004662 ANTAR domain; Region: ANTAR; pfam03861 410289004663 lipid-transfer protein; Provisional; Region: PRK06059 410289004664 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 410289004665 active site 410289004666 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 410289004667 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 410289004668 DUF35 OB-fold domain; Region: DUF35; pfam01796 410289004669 DNA polymerase I; Provisional; Region: PRK05755 410289004670 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 410289004671 active site 410289004672 metal binding site 1 [ion binding]; metal-binding site 410289004673 putative 5' ssDNA interaction site; other site 410289004674 metal binding site 3; metal-binding site 410289004675 metal binding site 2 [ion binding]; metal-binding site 410289004676 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 410289004677 putative DNA binding site [nucleotide binding]; other site 410289004678 putative metal binding site [ion binding]; other site 410289004679 3'-5' exonuclease; Region: 35EXOc; smart00474 410289004680 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 410289004681 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 410289004682 active site 410289004683 DNA binding site [nucleotide binding] 410289004684 catalytic site [active] 410289004685 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 410289004686 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 410289004687 RNA binding site [nucleotide binding]; other site 410289004688 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 410289004689 RNA binding site [nucleotide binding]; other site 410289004690 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 410289004691 RNA binding site [nucleotide binding]; other site 410289004692 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 410289004693 RNA binding site [nucleotide binding]; other site 410289004694 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 410289004695 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 410289004696 CoA-binding site [chemical binding]; other site 410289004697 ATP-binding [chemical binding]; other site 410289004698 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 410289004699 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 410289004700 excinuclease ABC subunit B; Provisional; Region: PRK05298 410289004701 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 410289004702 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 410289004703 nucleotide binding region [chemical binding]; other site 410289004704 ATP-binding site [chemical binding]; other site 410289004705 Ultra-violet resistance protein B; Region: UvrB; pfam12344 410289004706 UvrB/uvrC motif; Region: UVR; pfam02151 410289004707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289004708 Major Facilitator Superfamily; Region: MFS_1; pfam07690 410289004709 putative substrate translocation pore; other site 410289004710 Predicted membrane protein [Function unknown]; Region: COG5305 410289004711 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 410289004712 Ligand Binding Site [chemical binding]; other site 410289004713 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 410289004714 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 410289004715 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 410289004716 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 410289004717 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 410289004718 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 410289004719 Predicted esterase [General function prediction only]; Region: COG0627 410289004720 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 410289004721 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 410289004722 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 410289004723 dimer interface [polypeptide binding]; other site 410289004724 putative anticodon binding site; other site 410289004725 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 410289004726 motif 1; other site 410289004727 dimer interface [polypeptide binding]; other site 410289004728 active site 410289004729 motif 2; other site 410289004730 motif 3; other site 410289004731 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 410289004732 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 410289004733 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 410289004734 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 410289004735 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 410289004736 23S rRNA binding site [nucleotide binding]; other site 410289004737 L21 binding site [polypeptide binding]; other site 410289004738 L13 binding site [polypeptide binding]; other site 410289004739 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 410289004740 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 410289004741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 410289004742 PE family; Region: PE; pfam00934 410289004743 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 410289004744 cyclase homology domain; Region: CHD; cd07302 410289004745 nucleotidyl binding site; other site 410289004746 metal binding site [ion binding]; metal-binding site 410289004747 dimer interface [polypeptide binding]; other site 410289004748 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 410289004749 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 410289004750 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 410289004751 dimer interface [polypeptide binding]; other site 410289004752 motif 1; other site 410289004753 active site 410289004754 motif 2; other site 410289004755 motif 3; other site 410289004756 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 410289004757 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 410289004758 putative tRNA-binding site [nucleotide binding]; other site 410289004759 B3/4 domain; Region: B3_4; pfam03483 410289004760 tRNA synthetase B5 domain; Region: B5; smart00874 410289004761 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 410289004762 dimer interface [polypeptide binding]; other site 410289004763 motif 1; other site 410289004764 motif 3; other site 410289004765 motif 2; other site 410289004766 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 410289004767 PE family; Region: PE; pfam00934 410289004768 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 410289004769 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 410289004770 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 410289004771 heterotetramer interface [polypeptide binding]; other site 410289004772 active site pocket [active] 410289004773 cleavage site 410289004774 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 410289004775 feedback inhibition sensing region; other site 410289004776 homohexameric interface [polypeptide binding]; other site 410289004777 nucleotide binding site [chemical binding]; other site 410289004778 N-acetyl-L-glutamate binding site [chemical binding]; other site 410289004779 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 410289004780 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 410289004781 inhibitor-cofactor binding pocket; inhibition site 410289004782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289004783 catalytic residue [active] 410289004784 ornithine carbamoyltransferase; Provisional; Region: PRK00779 410289004785 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 410289004786 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 410289004787 arginine repressor; Provisional; Region: PRK03341 410289004788 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 410289004789 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 410289004790 argininosuccinate synthase; Provisional; Region: PRK13820 410289004791 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 410289004792 ANP binding site [chemical binding]; other site 410289004793 Substrate Binding Site II [chemical binding]; other site 410289004794 Substrate Binding Site I [chemical binding]; other site 410289004795 argininosuccinate lyase; Provisional; Region: PRK00855 410289004796 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 410289004797 active sites [active] 410289004798 tetramer interface [polypeptide binding]; other site 410289004799 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 410289004800 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 410289004801 malonyl-CoA binding site [chemical binding]; other site 410289004802 dimer interface [polypeptide binding]; other site 410289004803 active site 410289004804 product binding site; other site 410289004805 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 410289004806 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289004807 active site 410289004808 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 410289004809 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 410289004810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289004811 Enoylreductase; Region: PKS_ER; smart00829 410289004812 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 410289004813 NAD(P) binding site [chemical binding]; other site 410289004814 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 410289004815 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 410289004816 putative NADP binding site [chemical binding]; other site 410289004817 active site 410289004818 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289004819 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 410289004820 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289004821 active site 410289004822 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 410289004823 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 410289004824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289004825 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 410289004826 Enoylreductase; Region: PKS_ER; smart00829 410289004827 NAD(P) binding site [chemical binding]; other site 410289004828 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 410289004829 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 410289004830 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 410289004831 putative NADP binding site [chemical binding]; other site 410289004832 active site 410289004833 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289004834 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 410289004835 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289004836 active site 410289004837 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 410289004838 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 410289004839 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289004840 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 410289004841 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 410289004842 malonyl-CoA binding site [chemical binding]; other site 410289004843 dimer interface [polypeptide binding]; other site 410289004844 active site 410289004845 product binding site; other site 410289004846 Cytochrome P450; Region: p450; cl12078 410289004847 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289004848 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 410289004849 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 410289004850 ABC transporter; Region: ABC_tran_2; pfam12848 410289004851 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 410289004852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 410289004853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289004854 putative substrate translocation pore; other site 410289004855 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 410289004856 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 410289004857 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 410289004858 dimerization interface [polypeptide binding]; other site 410289004859 putative DNA binding site [nucleotide binding]; other site 410289004860 putative Zn2+ binding site [ion binding]; other site 410289004861 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 410289004862 active site residue [active] 410289004863 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 410289004864 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 410289004865 ligand binding site [chemical binding]; other site 410289004866 flexible hinge region; other site 410289004867 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 410289004868 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 410289004869 putative catalytic residues [active] 410289004870 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 410289004871 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 410289004872 catalytic residues [active] 410289004873 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289004874 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289004875 active site 410289004876 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 410289004877 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 410289004878 substrate binding pocket [chemical binding]; other site 410289004879 membrane-bound complex binding site; other site 410289004880 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 410289004881 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 410289004882 FeS/SAM binding site; other site 410289004883 DivIVA protein; Region: DivIVA; pfam05103 410289004884 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 410289004885 acyl-CoA synthetase; Validated; Region: PRK07868 410289004886 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 410289004887 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289004888 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289004889 acyl-activating enzyme (AAE) consensus motif; other site 410289004890 AMP binding site [chemical binding]; other site 410289004891 active site 410289004892 CoA binding site [chemical binding]; other site 410289004893 Uncharacterized conserved protein [Function unknown]; Region: COG2835 410289004894 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289004895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289004896 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 410289004897 ABC-2 type transporter; Region: ABC2_membrane; cl17235 410289004898 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 410289004899 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 410289004900 Walker A/P-loop; other site 410289004901 ATP binding site [chemical binding]; other site 410289004902 Q-loop/lid; other site 410289004903 ABC transporter signature motif; other site 410289004904 Walker B; other site 410289004905 D-loop; other site 410289004906 H-loop/switch region; other site 410289004907 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 410289004908 active site 410289004909 DNA binding site [nucleotide binding] 410289004910 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 410289004911 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 410289004912 active site 410289004913 HIGH motif; other site 410289004914 dimer interface [polypeptide binding]; other site 410289004915 KMSKS motif; other site 410289004916 S4 RNA-binding domain; Region: S4; smart00363 410289004917 RNA binding surface [nucleotide binding]; other site 410289004918 Protein of unknown function (DUF732); Region: DUF732; pfam05305 410289004919 Tetratrico peptide repeat; Region: TPR_5; pfam12688 410289004920 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 410289004921 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 410289004922 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 410289004923 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 410289004924 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 410289004925 RNA binding surface [nucleotide binding]; other site 410289004926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289004927 S-adenosylmethionine binding site [chemical binding]; other site 410289004928 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 410289004929 ATP-NAD kinase; Region: NAD_kinase; pfam01513 410289004930 DNA repair protein RecN; Region: recN; TIGR00634 410289004931 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 410289004932 Walker A/P-loop; other site 410289004933 ATP binding site [chemical binding]; other site 410289004934 Q-loop/lid; other site 410289004935 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 410289004936 ABC transporter signature motif; other site 410289004937 Walker B; other site 410289004938 D-loop; other site 410289004939 H-loop/switch region; other site 410289004940 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 410289004941 Thiamine pyrophosphokinase; Region: TPK; cl08415 410289004942 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 410289004943 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 410289004944 CTP synthetase; Validated; Region: pyrG; PRK05380 410289004945 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 410289004946 Catalytic site [active] 410289004947 active site 410289004948 UTP binding site [chemical binding]; other site 410289004949 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 410289004950 active site 410289004951 putative oxyanion hole; other site 410289004952 catalytic triad [active] 410289004953 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 410289004954 dimer interface [polypeptide binding]; other site 410289004955 ADP-ribose binding site [chemical binding]; other site 410289004956 active site 410289004957 nudix motif; other site 410289004958 metal binding site [ion binding]; metal-binding site 410289004959 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 410289004960 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 410289004961 active site 410289004962 DNA binding site [nucleotide binding] 410289004963 Int/Topo IB signature motif; other site 410289004964 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289004965 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289004966 active site 410289004967 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 410289004968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289004969 S-adenosylmethionine binding site [chemical binding]; other site 410289004970 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 410289004971 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289004972 PPE family; Region: PPE; pfam00823 410289004973 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 410289004974 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289004975 PPE family; Region: PPE; pfam00823 410289004976 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 410289004977 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 410289004978 Sulfate transporter family; Region: Sulfate_transp; pfam00916 410289004979 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 410289004980 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 410289004981 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 410289004982 P-loop; other site 410289004983 Magnesium ion binding site [ion binding]; other site 410289004984 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 410289004985 Magnesium ion binding site [ion binding]; other site 410289004986 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 410289004987 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 410289004988 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 410289004989 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 410289004990 RNA binding surface [nucleotide binding]; other site 410289004991 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 410289004992 active site 410289004993 cytidylate kinase; Provisional; Region: cmk; PRK00023 410289004994 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 410289004995 CMP-binding site; other site 410289004996 The sites determining sugar specificity; other site 410289004997 GTP-binding protein Der; Reviewed; Region: PRK03003 410289004998 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 410289004999 GTP/Mg2+ binding site [chemical binding]; other site 410289005000 Switch I region; other site 410289005001 G2 box; other site 410289005002 Switch II region; other site 410289005003 G3 box; other site 410289005004 G4 box; other site 410289005005 G5 box; other site 410289005006 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 410289005007 G1 box; other site 410289005008 GTP/Mg2+ binding site [chemical binding]; other site 410289005009 Switch I region; other site 410289005010 G2 box; other site 410289005011 G3 box; other site 410289005012 Switch II region; other site 410289005013 G4 box; other site 410289005014 G5 box; other site 410289005015 short chain dehydrogenase; Provisional; Region: PRK07060 410289005016 classical (c) SDRs; Region: SDR_c; cd05233 410289005017 NAD(P) binding site [chemical binding]; other site 410289005018 active site 410289005019 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 410289005020 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 410289005021 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 410289005022 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 410289005023 Cupin domain; Region: Cupin_2; pfam07883 410289005024 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 410289005025 Transcriptional regulator [Transcription]; Region: IclR; COG1414 410289005026 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 410289005027 putative switch regulator; other site 410289005028 non-specific DNA interactions [nucleotide binding]; other site 410289005029 DNA binding site [nucleotide binding] 410289005030 sequence specific DNA binding site [nucleotide binding]; other site 410289005031 putative cAMP binding site [chemical binding]; other site 410289005032 Bacterial transcriptional regulator; Region: IclR; pfam01614 410289005033 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 410289005034 putative active site [active] 410289005035 homotetrameric interface [polypeptide binding]; other site 410289005036 metal binding site [ion binding]; metal-binding site 410289005037 biotin carboxylase-like protein; Validated; Region: PRK06524 410289005038 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 410289005039 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 410289005040 Beta-lactamase; Region: Beta-lactamase; pfam00144 410289005041 Predicted transcriptional regulators [Transcription]; Region: COG1733 410289005042 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 410289005043 dimerization interface [polypeptide binding]; other site 410289005044 putative DNA binding site [nucleotide binding]; other site 410289005045 putative Zn2+ binding site [ion binding]; other site 410289005046 Predicted transcriptional regulators [Transcription]; Region: COG1733 410289005047 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 410289005048 FAD binding domain; Region: FAD_binding_4; pfam01565 410289005049 Berberine and berberine like; Region: BBE; pfam08031 410289005050 TIGR03086 family protein; Region: TIGR03086 410289005051 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 410289005052 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 410289005053 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 410289005054 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 410289005055 Beta-lactamase; Region: Beta-lactamase; pfam00144 410289005056 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 410289005057 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 410289005058 NAD(P) binding site [chemical binding]; other site 410289005059 catalytic residues [active] 410289005060 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 410289005061 putative catalytic residue [active] 410289005062 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 410289005063 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 410289005064 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 410289005065 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 410289005066 gating phenylalanine in ion channel; other site 410289005067 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 410289005068 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 410289005069 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 410289005070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289005071 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 410289005072 putative substrate translocation pore; other site 410289005073 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 410289005074 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 410289005075 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 410289005076 Sulfate transporter family; Region: Sulfate_transp; pfam00916 410289005077 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 410289005078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 410289005079 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 410289005080 putative active site [active] 410289005081 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 410289005082 Catalytic domain of Protein Kinases; Region: PKc; cd00180 410289005083 active site 410289005084 ATP binding site [chemical binding]; other site 410289005085 substrate binding site [chemical binding]; other site 410289005086 activation loop (A-loop); other site 410289005087 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 410289005088 Thioredoxin; Region: Thioredoxin_4; cl17273 410289005089 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 410289005090 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 410289005091 active site 410289005092 metal binding site [ion binding]; metal-binding site 410289005093 nudix motif; other site 410289005094 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 410289005095 Catalytic domain of Protein Kinases; Region: PKc; cd00180 410289005096 active site 410289005097 ATP binding site [chemical binding]; other site 410289005098 substrate binding site [chemical binding]; other site 410289005099 activation loop (A-loop); other site 410289005100 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 410289005101 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 410289005102 phosphopeptide binding site; other site 410289005103 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 410289005104 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 410289005105 phosphopeptide binding site; other site 410289005106 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 410289005107 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 410289005108 Walker A/P-loop; other site 410289005109 ATP binding site [chemical binding]; other site 410289005110 Q-loop/lid; other site 410289005111 ABC transporter signature motif; other site 410289005112 Walker B; other site 410289005113 D-loop; other site 410289005114 H-loop/switch region; other site 410289005115 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 410289005116 acyl-CoA synthetase; Provisional; Region: PRK13388 410289005117 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289005118 acyl-activating enzyme (AAE) consensus motif; other site 410289005119 AMP binding site [chemical binding]; other site 410289005120 active site 410289005121 CoA binding site [chemical binding]; other site 410289005122 hypothetical protein; Provisional; Region: PRK06185 410289005123 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 410289005124 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 410289005125 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 410289005126 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289005127 PPE family; Region: PPE; pfam00823 410289005128 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289005129 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289005130 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 410289005131 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 410289005132 Phosphoesterase family; Region: Phosphoesterase; pfam04185 410289005133 RvD2, 6804 bp. Region of Difference RvD2, substituted region in Mycobacterium bovis BCG Pasteur (position 1992782..1999585, 6804bp) and Mycobacterium bovis AF2122/97 (position 1973095..1979898, 6804bp ) compared to Mycobacterium tuberculosis H37Rv2 (position: 1987703..1989057, 1355bp). In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis AF2122/97, this region encodes genes equivalent to Mycobacterium tuberculosis strain CDC1551, MT1800-MT1802 and complete gene for plcD and cut1. In Mycobacterium tuberculosis strain H37Rv, insertion of an IS6110 element (encoding genes Rv1756c and Rv1757c) removes genes MT1800-MT1802 and truncates plcD(Rv1555c) and cut1(Rv1758) 410289005134 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 410289005135 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 410289005136 sulfite oxidase; Provisional; Region: PLN00177 410289005137 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 410289005138 Moco binding site; other site 410289005139 metal coordination site [ion binding]; other site 410289005140 dimerization interface [polypeptide binding]; other site 410289005141 Transport protein; Region: actII; TIGR00833 410289005142 Cutinase; Region: Cutinase; pfam01083 410289005143 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 410289005144 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 410289005145 Uncharacterized conserved protein [Function unknown]; Region: COG0393 410289005146 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 410289005147 RvD3, 953 bp/1352 bp. Region of difference RvD3, substituted region in Mycobacterium bovis BCG Pasteur (position 2006573..2007525, 953 bp), and Mycobacterium bovis AF2122/97 (position 1986940..1987892, 953bp) compared to Mycobacterium tuberculosis strain H37Rv (position 1996101..1997452, 1352bp). In Mycobacterium tuberculosis strain H37Rv, this region bears a copy of IS6110 while in Mycobacterium bovis BCG Pasteur and Mycobacterium bovis AF2122/97, this region encodes 2 genes, also found in Mycobacterium tuberculosis strain CDC1551, MT1812 and MT1813 410289005148 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 410289005149 Transcriptional regulator [Transcription]; Region: IclR; COG1414 410289005150 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289005151 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289005152 active site 410289005153 RD14, 9068 bp. Region of Difference RD14, deleted region in Mycobacterium bovis BCG Pasteur (position 2008298..2008299) compared to Mycobacterium tuberculosis H37Rv2 (position: 1998226..2007293) and Mycobacterium bovis AF2122/97 (position 1988666..1997751). Removes genes Rv1765A-Rv1772 and merges truncated genes Rv1773c and Rv1765c 410289005154 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 410289005155 FAD binding domain; Region: FAD_binding_4; pfam01565 410289005156 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289005157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289005158 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289005159 Cytochrome P450; Region: p450; cl12078 410289005160 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 410289005161 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 410289005162 Protein of unknown function (DUF690); Region: DUF690; pfam05108 410289005163 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 410289005164 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 410289005165 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 410289005166 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 410289005167 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289005168 Cytochrome P450; Region: p450; cl12078 410289005169 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 410289005170 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289005171 PPE family; Region: PPE; pfam00823 410289005172 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 410289005173 PE family; Region: PE; pfam00934 410289005174 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289005175 PPE family; Region: PPE; pfam00823 410289005176 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 410289005177 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289005178 PPE family; Region: PPE; pfam00823 410289005179 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 410289005180 PE family; Region: PE; pfam00934 410289005181 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 410289005182 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 410289005183 EspG family; Region: ESX-1_EspG; pfam14011 410289005184 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 410289005185 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 410289005186 catalytic residues [active] 410289005187 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 410289005188 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 410289005189 active site 410289005190 catalytic residues [active] 410289005191 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 410289005192 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 410289005193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289005194 Walker A motif; other site 410289005195 ATP binding site [chemical binding]; other site 410289005196 Walker B motif; other site 410289005197 arginine finger; other site 410289005198 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289005199 PPE family; Region: PPE; pfam00823 410289005200 PE-PPE domain; Region: PE-PPE; pfam08237 410289005201 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289005202 PPE family; Region: PPE; pfam00823 410289005203 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289005204 PPE family; Region: PPE; pfam00823 410289005205 PE family; Region: PE; pfam00934 410289005206 Protein of unknown function (DUF732); Region: DUF732; pfam05305 410289005207 PE family; Region: PE; pfam00934 410289005208 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289005209 PPE family; Region: PPE; pfam00823 410289005210 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289005211 PPE family; Region: PPE; pfam00823 410289005212 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289005213 PPE family; Region: PPE; pfam00823 410289005214 Protein of unknown function (DUF732); Region: DUF732; pfam05305 410289005215 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 410289005216 MgtC family; Region: MgtC; pfam02308 410289005217 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 410289005218 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 410289005219 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 410289005220 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 410289005221 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 410289005222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289005223 similar to hypothetical protein 410289005224 hypothetical protein; Validated; Region: PRK07121 410289005225 PE family; Region: PE; pfam00934 410289005226 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 410289005227 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 410289005228 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 410289005229 hypothetical protein; Provisional; Region: PRK05858 410289005230 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 410289005231 PYR/PP interface [polypeptide binding]; other site 410289005232 dimer interface [polypeptide binding]; other site 410289005233 TPP binding site [chemical binding]; other site 410289005234 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 410289005235 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 410289005236 TPP-binding site; other site 410289005237 dimer interface [polypeptide binding]; other site 410289005238 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 410289005239 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 410289005240 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 410289005241 nucleotide binding region [chemical binding]; other site 410289005242 ATP-binding site [chemical binding]; other site 410289005243 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 410289005244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 410289005245 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 410289005246 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 410289005247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 410289005248 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 410289005249 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 410289005250 lipoyl attachment site [posttranslational modification]; other site 410289005251 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 410289005252 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 410289005253 phosphopeptide binding site; other site 410289005254 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 410289005255 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 410289005256 DNA binding residues [nucleotide binding] 410289005257 Bifunctional nuclease; Region: DNase-RNase; pfam02577 410289005258 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 410289005259 DNA binding residues [nucleotide binding] 410289005260 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 410289005261 putative dimer interface [polypeptide binding]; other site 410289005262 glycine dehydrogenase; Provisional; Region: PRK05367 410289005263 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 410289005264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289005265 tetramer interface [polypeptide binding]; other site 410289005266 catalytic residue [active] 410289005267 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 410289005268 tetramer interface [polypeptide binding]; other site 410289005269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289005270 catalytic residue [active] 410289005271 haloalkane dehalogenase; Provisional; Region: PRK03204 410289005272 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 410289005273 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 410289005274 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 410289005275 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 410289005276 metal ion-dependent adhesion site (MIDAS); other site 410289005277 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 410289005278 active site 410289005279 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 410289005280 putative active site [active] 410289005281 Domain of unknown function DUF21; Region: DUF21; pfam01595 410289005282 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 410289005283 FOG: CBS domain [General function prediction only]; Region: COG0517 410289005284 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 410289005285 Domain of unknown function DUF21; Region: DUF21; pfam01595 410289005286 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 410289005287 Transporter associated domain; Region: CorC_HlyC; smart01091 410289005288 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 410289005289 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 410289005290 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 410289005291 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 410289005292 active site 410289005293 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 410289005294 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 410289005295 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 410289005296 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 410289005297 Predicted transcriptional regulator [Transcription]; Region: COG3682 410289005298 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 410289005299 CoenzymeA binding site [chemical binding]; other site 410289005300 subunit interaction site [polypeptide binding]; other site 410289005301 PHB binding site; other site 410289005302 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 410289005303 alpha-gamma subunit interface [polypeptide binding]; other site 410289005304 beta-gamma subunit interface [polypeptide binding]; other site 410289005305 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 410289005306 gamma-beta subunit interface [polypeptide binding]; other site 410289005307 alpha-beta subunit interface [polypeptide binding]; other site 410289005308 urease subunit alpha; Reviewed; Region: ureC; PRK13206 410289005309 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 410289005310 subunit interactions [polypeptide binding]; other site 410289005311 active site 410289005312 flap region; other site 410289005313 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 410289005314 UreF; Region: UreF; pfam01730 410289005315 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 410289005316 UreD urease accessory protein; Region: UreD; cl00530 410289005317 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 410289005318 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 410289005319 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 410289005320 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 410289005321 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 410289005322 classical (c) SDRs; Region: SDR_c; cd05233 410289005323 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 410289005324 NAD(P) binding site [chemical binding]; other site 410289005325 active site 410289005326 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 410289005327 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 410289005328 sulfate transport protein; Provisional; Region: cysT; CHL00187 410289005329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289005330 dimer interface [polypeptide binding]; other site 410289005331 conserved gate region; other site 410289005332 putative PBP binding loops; other site 410289005333 ABC-ATPase subunit interface; other site 410289005334 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 410289005335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289005336 Walker A/P-loop; other site 410289005337 ATP binding site [chemical binding]; other site 410289005338 Q-loop/lid; other site 410289005339 ABC transporter signature motif; other site 410289005340 Walker B; other site 410289005341 D-loop; other site 410289005342 H-loop/switch region; other site 410289005343 TOBE domain; Region: TOBE; pfam03459 410289005344 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 410289005345 Predicted membrane protein [Function unknown]; Region: COG2261 410289005346 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 410289005347 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 410289005348 putative NAD(P) binding site [chemical binding]; other site 410289005349 putative substrate binding site [chemical binding]; other site 410289005350 catalytic Zn binding site [ion binding]; other site 410289005351 structural Zn binding site [ion binding]; other site 410289005352 CAAX protease self-immunity; Region: Abi; pfam02517 410289005353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 410289005354 MOSC domain; Region: MOSC; pfam03473 410289005355 short chain dehydrogenase; Provisional; Region: PRK07825 410289005356 classical (c) SDRs; Region: SDR_c; cd05233 410289005357 NAD(P) binding site [chemical binding]; other site 410289005358 active site 410289005359 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 410289005360 CoA-transferase family III; Region: CoA_transf_3; pfam02515 410289005361 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 410289005362 CoA-transferase family III; Region: CoA_transf_3; pfam02515 410289005363 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 410289005364 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 410289005365 active site 410289005366 hypothetical protein; Provisional; Region: PRK12320 410289005367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289005368 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 410289005369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 410289005370 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 410289005371 Domain of unknown function (DUF385); Region: DUF385; pfam04075 410289005372 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 410289005373 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 410289005374 active site 410289005375 substrate binding site [chemical binding]; other site 410289005376 FMN binding site [chemical binding]; other site 410289005377 putative catalytic residues [active] 410289005378 Uncharacterized conserved protein [Function unknown]; Region: COG5579 410289005379 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 410289005380 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 410289005381 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 410289005382 heme binding site [chemical binding]; other site 410289005383 ferroxidase pore; other site 410289005384 ferroxidase diiron center [ion binding]; other site 410289005385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289005386 putative substrate translocation pore; other site 410289005387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289005388 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 410289005389 23S rRNA interface [nucleotide binding]; other site 410289005390 L3 interface [polypeptide binding]; other site 410289005391 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 410289005392 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 410289005393 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 410289005394 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 410289005395 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289005396 Cytochrome P450; Region: p450; cl12078 410289005397 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 410289005398 short chain dehydrogenase; Provisional; Region: PRK08267 410289005399 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 410289005400 putative NAD(P) binding site [chemical binding]; other site 410289005401 active site 410289005402 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 410289005403 hydrophobic ligand binding site; other site 410289005404 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 410289005405 chorismate mutase; Provisional; Region: PRK09269 410289005406 chorismate mutase, putative; Region: CM_mono2; TIGR01806 410289005407 Putative esterase; Region: Esterase; pfam00756 410289005408 Leucine carboxyl methyltransferase; Region: LCM; cl01306 410289005409 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 410289005410 Leucine carboxyl methyltransferase; Region: LCM; cl01306 410289005411 Uncharacterized conserved protein [Function unknown]; Region: COG2353 410289005412 Nitronate monooxygenase; Region: NMO; pfam03060 410289005413 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 410289005414 FMN binding site [chemical binding]; other site 410289005415 substrate binding site [chemical binding]; other site 410289005416 putative catalytic residue [active] 410289005417 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 410289005418 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 410289005419 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 410289005420 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 410289005421 NAD(P) binding site [chemical binding]; other site 410289005422 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 410289005423 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 410289005424 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 410289005425 putative active site [active] 410289005426 dimerization interface [polypeptide binding]; other site 410289005427 putative tRNAtyr binding site [nucleotide binding]; other site 410289005428 Domain of unknown function DUF77; Region: DUF77; pfam01910 410289005429 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 410289005430 putative ADP-ribose binding site [chemical binding]; other site 410289005431 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 410289005432 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 410289005433 cyclase homology domain; Region: CHD; cd07302 410289005434 nucleotidyl binding site; other site 410289005435 metal binding site [ion binding]; metal-binding site 410289005436 dimer interface [polypeptide binding]; other site 410289005437 competence damage-inducible protein A; Provisional; Region: PRK00549 410289005438 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 410289005439 putative MPT binding site; other site 410289005440 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 410289005441 putative sialic acid transporter; Region: 2A0112; TIGR00891 410289005442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289005443 putative substrate translocation pore; other site 410289005444 Predicted membrane protein [Function unknown]; Region: COG1950 410289005445 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 410289005446 anti sigma factor interaction site; other site 410289005447 regulatory phosphorylation site [posttranslational modification]; other site 410289005448 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 410289005449 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 410289005450 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 410289005451 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 410289005452 dimer interface [polypeptide binding]; other site 410289005453 active site 410289005454 heme binding site [chemical binding]; other site 410289005455 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 410289005456 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 410289005457 metal binding site 2 [ion binding]; metal-binding site 410289005458 putative DNA binding helix; other site 410289005459 metal binding site 1 [ion binding]; metal-binding site 410289005460 dimer interface [polypeptide binding]; other site 410289005461 structural Zn2+ binding site [ion binding]; other site 410289005462 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 410289005463 substrate binding site [chemical binding]; other site 410289005464 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 410289005465 substrate binding site [chemical binding]; other site 410289005466 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 410289005467 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 410289005468 putative NAD(P) binding site [chemical binding]; other site 410289005469 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 410289005470 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 410289005471 tetramer interface [polypeptide binding]; other site 410289005472 active site 410289005473 Mg2+/Mn2+ binding site [ion binding]; other site 410289005474 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 410289005475 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289005476 PPE family; Region: PPE; pfam00823 410289005477 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289005478 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289005479 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289005480 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289005481 I-RD03, 552 bp. Region of Difference I-RD03, inserted region in Mycobacterium bovis BCG Pasteur (position 2164395..2164946, 552bp) and Mycobacterium bovis AF2122/97 (position 2153645..2154127, 483bp) compared to Mycobacterium tuberculosis H37Rv2 (position: 2163375..2163376). In-frame insertion in PPE34 gene 410289005482 S-RD04, 628 bp. Region of Difference S-RD04, inserted region in Mycobacterium bovis BCG Pasteur (position 2167434..2168061, 628bp) and Mycobacterium bovis AF2122/97 (position 2156909..2157536, 628bp) compared to Mycobacterium tuberculosis H37Rv2 (position: 2165851-2165902, 52bp). In-frame insertion in PPE34 gene 410289005483 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289005484 PPE family; Region: PPE; pfam00823 410289005485 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289005486 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289005487 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 410289005488 putative hydrophobic ligand binding site [chemical binding]; other site 410289005489 protein interface [polypeptide binding]; other site 410289005490 gate; other site 410289005491 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 410289005492 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 410289005493 putative acyl-acceptor binding pocket; other site 410289005494 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 410289005495 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 410289005496 Beta-lactamase; Region: Beta-lactamase; pfam00144 410289005497 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 410289005498 Beta-lactamase; Region: Beta-lactamase; pfam00144 410289005499 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 410289005500 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 410289005501 acyl-activating enzyme (AAE) consensus motif; other site 410289005502 active site 410289005503 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 410289005504 Uncharacterized conserved protein [Function unknown]; Region: COG3361 410289005505 short chain dehydrogenase; Provisional; Region: PRK05867 410289005506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289005507 NAD(P) binding site [chemical binding]; other site 410289005508 active site 410289005509 TIGR03085 family protein; Region: TIGR03085 410289005510 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 410289005511 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 410289005512 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 410289005513 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 410289005514 conserved cys residue [active] 410289005515 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 410289005516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 410289005517 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 410289005518 dimer interface [polypeptide binding]; other site 410289005519 catalytic triad [active] 410289005520 peroxidatic and resolving cysteines [active] 410289005521 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289005522 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 410289005523 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 410289005524 active site 410289005525 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289005526 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 410289005527 FAD binding site [chemical binding]; other site 410289005528 substrate binding site [chemical binding]; other site 410289005529 catalytic base [active] 410289005530 enoyl-CoA hydratase; Provisional; Region: PRK08290 410289005531 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289005532 substrate binding site [chemical binding]; other site 410289005533 oxyanion hole (OAH) forming residues; other site 410289005534 trimer interface [polypeptide binding]; other site 410289005535 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 410289005536 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 410289005537 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 410289005538 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 410289005539 catalytic loop [active] 410289005540 iron binding site [ion binding]; other site 410289005541 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 410289005542 FAD binding pocket [chemical binding]; other site 410289005543 FAD binding motif [chemical binding]; other site 410289005544 phosphate binding motif [ion binding]; other site 410289005545 beta-alpha-beta structure motif; other site 410289005546 NAD binding pocket [chemical binding]; other site 410289005547 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 410289005548 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 410289005549 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 410289005550 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 410289005551 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 410289005552 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 410289005553 dimerization interface [polypeptide binding]; other site 410289005554 active site 410289005555 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 410289005556 putative NAD(P) binding site [chemical binding]; other site 410289005557 active site 410289005558 homodimer interface [polypeptide binding]; other site 410289005559 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 410289005560 SEC-C motif; Region: SEC-C; pfam02810 410289005561 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289005562 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289005563 active site 410289005564 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 410289005565 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 410289005566 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 410289005567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 410289005568 non-specific DNA binding site [nucleotide binding]; other site 410289005569 salt bridge; other site 410289005570 sequence-specific DNA binding site [nucleotide binding]; other site 410289005571 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 410289005572 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 410289005573 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 410289005574 putative active site [active] 410289005575 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 410289005576 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289005577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289005578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289005579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289005580 Permease; Region: Permease; cl00510 410289005581 RD7, 12719 bp. Region of Difference RD7, deleted region in Mycobacterium bovis BCG Pasteur (position 2210166..2210167) and Mycobacterium bovis AF2122/97 (position 2199640..2199641) compared to Mycobacterium tuberculosis H37Rv2 (position: 2208006..2220724) . Removes genes Rv1965-Rv1977 and truncates genes Rv1964 and Rv1978. Immediatly followed, in Mycobacterium bovis BCG Pasteur (position 2210500..2210501), by a second deletion of 10787bp, RD2 region, which removes genes Rv1979c-Rv1787 and merges truncated genes Rv1978 and Rv1988 410289005582 Ribosomal RNA adenine dimethylases; Region: rADc; smart00650 410289005583 RD2, 10787 bp. Region of Difference RD2, deleted region in Mycobacterium bovis BCG Pasteur (position 2210500..2210501) compared to Mycobacterium tuberculosis H37Rv2 (position: 2221059..2231845) and Mycobacterium bovis AF2122/97 (position 2199975..2210761). Removes genes Rv1979-Rv1987, and merges truncated part of Rv1978 and Rv1988. This region is downstream of a previous deletion of 12719bp, RD7 region, specific to Mycobacterium bovis BCG Pasteur which removes genes Rv1965-Rv1977 and truncates Rv1964 and Rv1978 410289005584 Uncharacterized conserved protein [Function unknown]; Region: COG5654 410289005585 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 410289005586 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 410289005587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289005588 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 410289005589 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 410289005590 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 410289005591 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 410289005592 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 410289005593 dimerization interface [polypeptide binding]; other site 410289005594 putative DNA binding site [nucleotide binding]; other site 410289005595 putative Zn2+ binding site [ion binding]; other site 410289005596 Hemerythrin-like domain; Region: Hr-like; cd12108 410289005597 Fe binding site [ion binding]; other site 410289005598 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 410289005599 Ligand Binding Site [chemical binding]; other site 410289005600 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 410289005601 Ligand Binding Site [chemical binding]; other site 410289005602 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 410289005603 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 410289005604 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 410289005605 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 410289005606 Soluble P-type ATPase [General function prediction only]; Region: COG4087 410289005607 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 410289005608 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 410289005609 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 410289005610 tetramer interface [polypeptide binding]; other site 410289005611 active site 410289005612 Mg2+/Mn2+ binding site [ion binding]; other site 410289005613 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 410289005614 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 410289005615 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 410289005616 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 410289005617 homotetramer interface [polypeptide binding]; other site 410289005618 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 410289005619 NAD binding site [chemical binding]; other site 410289005620 homodimer interface [polypeptide binding]; other site 410289005621 active site 410289005622 Methyltransferase domain; Region: Methyltransf_23; pfam13489 410289005623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289005624 S-adenosylmethionine binding site [chemical binding]; other site 410289005625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 410289005626 Predicted kinase [General function prediction only]; Region: COG0645 410289005627 AAA domain; Region: AAA_17; pfam13207 410289005628 Universal stress protein family; Region: Usp; pfam00582 410289005629 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 410289005630 Ligand Binding Site [chemical binding]; other site 410289005631 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 410289005632 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 410289005633 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 410289005634 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 410289005635 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 410289005636 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 410289005637 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 410289005638 Ferredoxin [Energy production and conversion]; Region: COG1146 410289005639 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 410289005640 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 410289005641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289005642 Walker A motif; other site 410289005643 ATP binding site [chemical binding]; other site 410289005644 Walker B motif; other site 410289005645 arginine finger; other site 410289005646 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 410289005647 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 410289005648 putative active site [active] 410289005649 Transcriptional regulators [Transcription]; Region: MarR; COG1846 410289005650 MarR family; Region: MarR_2; pfam12802 410289005651 Phage envelope protein [General function prediction only]; Region: COG5562 410289005652 Transposase; Region: DEDD_Tnp_IS110; pfam01548 410289005653 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 410289005654 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 410289005655 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 410289005656 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289005657 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289005658 active site 410289005659 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 410289005660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 410289005661 non-specific DNA binding site [nucleotide binding]; other site 410289005662 salt bridge; other site 410289005663 sequence-specific DNA binding site [nucleotide binding]; other site 410289005664 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 410289005665 Uncharacterized conserved protein [Function unknown]; Region: COG2442 410289005666 Predicted helicase [General function prediction only]; Region: COG4889 410289005667 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 410289005668 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 410289005669 non-specific DNA binding site [nucleotide binding]; other site 410289005670 salt bridge; other site 410289005671 sequence-specific DNA binding site [nucleotide binding]; other site 410289005672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 410289005673 RvD1, 5000 bp. Region of Difference RvD1, inserted region in Mycobacterium bovis BCG Pasteur (position 2247374..2252373, 5000bp) and Mycobacterium bovis AF2122/97 (position 2247638..2252637, 5000bp) compared to Mycobacterium tuberculosis H37Rv2 (position: 2268721..2268722). Leads to 2 extra genes, Mb2046c and Mb2047c and a longer one, Rv2024c 410289005674 Predicted helicase [General function prediction only]; Region: COG4889 410289005675 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 410289005676 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 410289005677 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 410289005678 ATP binding site [chemical binding]; other site 410289005679 putative Mg++ binding site [ion binding]; other site 410289005680 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 410289005681 ATP-binding site [chemical binding]; other site 410289005682 Methyltransferase domain; Region: Methyltransf_26; pfam13659 410289005683 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 410289005684 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 410289005685 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 410289005686 Ligand Binding Site [chemical binding]; other site 410289005687 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 410289005688 Ligand Binding Site [chemical binding]; other site 410289005689 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 410289005690 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 410289005691 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 410289005692 Histidine kinase; Region: HisKA_3; pfam07730 410289005693 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 410289005694 Ligand Binding Site [chemical binding]; other site 410289005695 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 410289005696 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 410289005697 putative substrate binding site [chemical binding]; other site 410289005698 putative ATP binding site [chemical binding]; other site 410289005699 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 410289005700 active site 410289005701 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 410289005702 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 410289005703 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 410289005704 putative dimer interface [polypeptide binding]; other site 410289005705 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 410289005706 dimer interface [polypeptide binding]; other site 410289005707 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 410289005708 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 410289005709 putative DNA binding site [nucleotide binding]; other site 410289005710 dimerization interface [polypeptide binding]; other site 410289005711 putative Zn2+ binding site [ion binding]; other site 410289005712 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 410289005713 putative hydrophobic ligand binding site [chemical binding]; other site 410289005714 CLM binding site; other site 410289005715 L1 loop; other site 410289005716 DNA binding site [nucleotide binding] 410289005717 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 410289005718 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 410289005719 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 410289005720 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 410289005721 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 410289005722 nucleophile elbow; other site 410289005723 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 410289005724 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 410289005725 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 410289005726 Walker A/P-loop; other site 410289005727 ATP binding site [chemical binding]; other site 410289005728 Q-loop/lid; other site 410289005729 ABC transporter signature motif; other site 410289005730 Walker B; other site 410289005731 D-loop; other site 410289005732 H-loop/switch region; other site 410289005733 TOBE domain; Region: TOBE_2; pfam08402 410289005734 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 410289005735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289005736 dimer interface [polypeptide binding]; other site 410289005737 conserved gate region; other site 410289005738 putative PBP binding loops; other site 410289005739 ABC-ATPase subunit interface; other site 410289005740 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 410289005741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289005742 dimer interface [polypeptide binding]; other site 410289005743 conserved gate region; other site 410289005744 putative PBP binding loops; other site 410289005745 ABC-ATPase subunit interface; other site 410289005746 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 410289005747 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 410289005748 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 410289005749 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 410289005750 Isochorismatase family; Region: Isochorismatase; pfam00857 410289005751 catalytic triad [active] 410289005752 metal binding site [ion binding]; metal-binding site 410289005753 conserved cis-peptide bond; other site 410289005754 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 410289005755 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 410289005756 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 410289005757 substrate binding pocket [chemical binding]; other site 410289005758 catalytic triad [active] 410289005759 hypothetical protein; Provisional; Region: PRK05865 410289005760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289005761 NAD(P) binding site [chemical binding]; other site 410289005762 active site 410289005763 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 410289005764 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 410289005765 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289005766 active site 410289005767 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 410289005768 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 410289005769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289005770 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 410289005771 Enoylreductase; Region: PKS_ER; smart00829 410289005772 NAD(P) binding site [chemical binding]; other site 410289005773 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 410289005774 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 410289005775 putative NADP binding site [chemical binding]; other site 410289005776 active site 410289005777 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289005778 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 410289005779 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289005780 active site 410289005781 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 410289005782 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 410289005783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289005784 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 410289005785 Enoylreductase; Region: PKS_ER; smart00829 410289005786 NAD(P) binding site [chemical binding]; other site 410289005787 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 410289005788 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 410289005789 putative NADP binding site [chemical binding]; other site 410289005790 active site 410289005791 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289005792 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 410289005793 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 410289005794 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 410289005795 putative active site [active] 410289005796 catalytic triad [active] 410289005797 putative dimer interface [polypeptide binding]; other site 410289005798 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 410289005799 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 410289005800 Ligand binding site; other site 410289005801 Putative Catalytic site; other site 410289005802 DXD motif; other site 410289005803 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 410289005804 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 410289005805 active site 410289005806 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 410289005807 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 410289005808 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 410289005809 30S ribosomal protein S18; Provisional; Region: PRK13401 410289005810 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 410289005811 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 410289005812 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 410289005813 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 410289005814 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 410289005815 intersubunit interface [polypeptide binding]; other site 410289005816 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 410289005817 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 410289005818 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 410289005819 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 410289005820 precorrin-3B synthase; Region: CobG; TIGR02435 410289005821 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 410289005822 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 410289005823 Precorrin-8X methylmutase; Region: CbiC; pfam02570 410289005824 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 410289005825 active site 410289005826 SAM binding site [chemical binding]; other site 410289005827 homodimer interface [polypeptide binding]; other site 410289005828 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 410289005829 active site 410289005830 SAM binding site [chemical binding]; other site 410289005831 homodimer interface [polypeptide binding]; other site 410289005832 Methyltransferase domain; Region: Methyltransf_31; pfam13847 410289005833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289005834 S-adenosylmethionine binding site [chemical binding]; other site 410289005835 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 410289005836 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 410289005837 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 410289005838 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 410289005839 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 410289005840 DNA binding residues [nucleotide binding] 410289005841 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 410289005842 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 410289005843 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 410289005844 active site 410289005845 SAM binding site [chemical binding]; other site 410289005846 homodimer interface [polypeptide binding]; other site 410289005847 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 410289005848 active site 410289005849 SAM binding site [chemical binding]; other site 410289005850 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 410289005851 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 410289005852 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 410289005853 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 410289005854 active site 410289005855 catalytic site [active] 410289005856 RD9, 2029 bp. Region of Difference RD9, deleted region in Mycobacterium bovis BCG Pasteur (position 2313726..2313727) and Mycobacterium bovis AF2122/97 (position 2313987..2313988) compared to Mycobacterium tuberculosis H37Rv2 (position: 2330073..2332101). Removes genes Rv2073-Rv2074 and truncates Rv2075c 410289005857 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 410289005858 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 410289005859 putative transposase OrfB; Reviewed; Region: PHA02517 410289005860 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 410289005861 Catalytic domain of Protein Kinases; Region: PKc; cd00180 410289005862 active site 410289005863 ATP binding site [chemical binding]; other site 410289005864 substrate binding site [chemical binding]; other site 410289005865 activation loop (A-loop); other site 410289005866 PknH-like extracellular domain; Region: PknH_C; pfam14032 410289005867 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 410289005868 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 410289005869 active site 410289005870 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 410289005871 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 410289005872 active site 410289005873 metal binding site 1 [ion binding]; metal-binding site 410289005874 putative 5' ssDNA interaction site; other site 410289005875 metal binding site 3; metal-binding site 410289005876 metal binding site 2 [ion binding]; metal-binding site 410289005877 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 410289005878 putative DNA binding site [nucleotide binding]; other site 410289005879 putative metal binding site [ion binding]; other site 410289005880 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 410289005881 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 410289005882 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 410289005883 ATP binding site [chemical binding]; other site 410289005884 putative Mg++ binding site [ion binding]; other site 410289005885 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 410289005886 nucleotide binding region [chemical binding]; other site 410289005887 ATP-binding site [chemical binding]; other site 410289005888 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 410289005889 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 410289005890 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 410289005891 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 410289005892 Predicted transcriptional regulator [Transcription]; Region: COG2378 410289005893 WYL domain; Region: WYL; pfam13280 410289005894 Predicted transcriptional regulator [Transcription]; Region: COG2378 410289005895 WYL domain; Region: WYL; pfam13280 410289005896 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 410289005897 PE family; Region: PE; pfam00934 410289005898 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289005899 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289005900 active site 410289005901 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 410289005902 SNF2 Helicase protein; Region: DUF3670; pfam12419 410289005903 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 410289005904 ATP binding site [chemical binding]; other site 410289005905 putative Mg++ binding site [ion binding]; other site 410289005906 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 410289005907 nucleotide binding region [chemical binding]; other site 410289005908 ATP-binding site [chemical binding]; other site 410289005909 Uncharacterized conserved protein [Function unknown]; Region: COG4279 410289005910 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 410289005911 putative active site [active] 410289005912 PE family; Region: PE; pfam00934 410289005913 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289005914 PPE family; Region: PPE; pfam00823 410289005915 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 410289005916 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 410289005917 active site 410289005918 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 410289005919 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 410289005920 active site 410289005921 Pup-like protein; Region: Pup; pfam05639 410289005922 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 410289005923 proteasome ATPase; Region: pup_AAA; TIGR03689 410289005924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289005925 Walker A motif; other site 410289005926 ATP binding site [chemical binding]; other site 410289005927 Walker B motif; other site 410289005928 arginine finger; other site 410289005929 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 410289005930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 410289005931 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 410289005932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289005933 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 410289005934 Predicted membrane protein [Function unknown]; Region: COG3918 410289005935 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 410289005936 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 410289005937 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 410289005938 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 410289005939 homodimer interface [polypeptide binding]; other site 410289005940 putative metal binding site [ion binding]; other site 410289005941 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289005942 PPE family; Region: PPE; pfam00823 410289005943 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 410289005944 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 410289005945 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 410289005946 substrate binding pocket [chemical binding]; other site 410289005947 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 410289005948 B12 binding site [chemical binding]; other site 410289005949 cobalt ligand [ion binding]; other site 410289005950 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 410289005951 PAC2 family; Region: PAC2; pfam09754 410289005952 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 410289005953 short chain dehydrogenase; Provisional; Region: PRK05872 410289005954 classical (c) SDRs; Region: SDR_c; cd05233 410289005955 NAD(P) binding site [chemical binding]; other site 410289005956 active site 410289005957 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 410289005958 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 410289005959 active site 410289005960 HIGH motif; other site 410289005961 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 410289005962 active site 410289005963 KMSKS motif; other site 410289005964 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 410289005965 putative tRNA binding surface [nucleotide binding]; other site 410289005966 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 410289005967 active site 410289005968 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 410289005969 conserved hypothetical protein; Region: TIGR03843 410289005970 conserved hypothetical protein; Region: TIGR03847 410289005971 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 410289005972 catalytic core [active] 410289005973 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 410289005974 dihydroorotate dehydrogenase, subfamily 2; Region: pyrD_sub2; TIGR01036 410289005975 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 410289005976 quinone interaction residues [chemical binding]; other site 410289005977 active site 410289005978 catalytic residues [active] 410289005979 FMN binding site [chemical binding]; other site 410289005980 substrate binding site [chemical binding]; other site 410289005981 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 410289005982 substrate binding site [chemical binding]; other site 410289005983 hypothetical protein; Provisional; Region: PRK07906 410289005984 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 410289005985 putative metal binding site [ion binding]; other site 410289005986 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 410289005987 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 410289005988 active site 410289005989 DivIVA domain; Region: DivI1A_domain; TIGR03544 410289005990 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 410289005991 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 410289005992 Predicted integral membrane protein [Function unknown]; Region: COG0762 410289005993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 410289005994 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 410289005995 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 410289005996 catalytic residue [active] 410289005997 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 410289005998 uncharacterized protein, YfiH family; Region: TIGR00726 410289005999 cell division protein FtsZ; Validated; Region: PRK09330 410289006000 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 410289006001 nucleotide binding site [chemical binding]; other site 410289006002 SulA interaction site; other site 410289006003 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 410289006004 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 410289006005 Cell division protein FtsQ; Region: FtsQ; pfam03799 410289006006 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 410289006007 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 410289006008 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 410289006009 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 410289006010 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 410289006011 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 410289006012 active site 410289006013 homodimer interface [polypeptide binding]; other site 410289006014 cell division protein FtsW; Region: ftsW; TIGR02614 410289006015 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 410289006016 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 410289006017 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 410289006018 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 410289006019 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 410289006020 Mg++ binding site [ion binding]; other site 410289006021 putative catalytic motif [active] 410289006022 putative substrate binding site [chemical binding]; other site 410289006023 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 410289006024 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 410289006025 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 410289006026 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 410289006027 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 410289006028 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 410289006029 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 410289006030 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289006031 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289006032 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 410289006033 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 410289006034 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 410289006035 PE family; Region: PE; pfam00934 410289006036 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 410289006037 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 410289006038 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 410289006039 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 410289006040 MraW methylase family; Region: Methyltransf_5; pfam01795 410289006041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 410289006042 MraZ protein; Region: MraZ; pfam02381 410289006043 MraZ protein; Region: MraZ; pfam02381 410289006044 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 410289006045 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 410289006046 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 410289006047 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 410289006048 substrate binding pocket [chemical binding]; other site 410289006049 chain length determination region; other site 410289006050 substrate-Mg2+ binding site; other site 410289006051 catalytic residues [active] 410289006052 aspartate-rich region 1; other site 410289006053 active site lid residues [active] 410289006054 aspartate-rich region 2; other site 410289006055 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 410289006056 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 410289006057 Catalytic domain of Protein Kinases; Region: PKc; cd00180 410289006058 active site 410289006059 ATP binding site [chemical binding]; other site 410289006060 substrate binding site [chemical binding]; other site 410289006061 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 410289006062 substrate binding site [chemical binding]; other site 410289006063 activation loop (A-loop); other site 410289006064 activation loop (A-loop); other site 410289006065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 410289006066 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 410289006067 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 410289006068 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 410289006069 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 410289006070 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 410289006071 putative acyl-acceptor binding pocket; other site 410289006072 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 410289006073 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 410289006074 DTAP/Switch II; other site 410289006075 Switch I; other site 410289006076 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 410289006077 putative hydrophobic ligand binding site [chemical binding]; other site 410289006078 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289006079 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 410289006080 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 410289006081 acyl-activating enzyme (AAE) consensus motif; other site 410289006082 putative AMP binding site [chemical binding]; other site 410289006083 putative active site [active] 410289006084 putative CoA binding site [chemical binding]; other site 410289006085 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 410289006086 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 410289006087 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 410289006088 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 410289006089 NlpC/P60 family; Region: NLPC_P60; pfam00877 410289006090 hypothetical protein; Validated; Region: PRK07883 410289006091 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 410289006092 active site 410289006093 catalytic site [active] 410289006094 substrate binding site [chemical binding]; other site 410289006095 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 410289006096 GIY-YIG motif/motif A; other site 410289006097 active site 410289006098 catalytic site [active] 410289006099 putative DNA binding site [nucleotide binding]; other site 410289006100 metal binding site [ion binding]; metal-binding site 410289006101 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 410289006102 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 410289006103 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 410289006104 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 410289006105 Subunit I/III interface [polypeptide binding]; other site 410289006106 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 410289006107 Cytochrome c; Region: Cytochrom_C; pfam00034 410289006108 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 410289006109 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 410289006110 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 410289006111 iron-sulfur cluster [ion binding]; other site 410289006112 [2Fe-2S] cluster binding site [ion binding]; other site 410289006113 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 410289006114 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 410289006115 heme bH binding site [chemical binding]; other site 410289006116 intrachain domain interface; other site 410289006117 heme bL binding site [chemical binding]; other site 410289006118 interchain domain interface [polypeptide binding]; other site 410289006119 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 410289006120 Qo binding site; other site 410289006121 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 410289006122 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 410289006123 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 410289006124 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 410289006125 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 410289006126 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 410289006127 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 410289006128 dimer interface [polypeptide binding]; other site 410289006129 active site 410289006130 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 410289006131 Ligand Binding Site [chemical binding]; other site 410289006132 Molecular Tunnel; other site 410289006133 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 410289006134 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 410289006135 substrate binding site [chemical binding]; other site 410289006136 ATP binding site [chemical binding]; other site 410289006137 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 410289006138 Glycerate kinase family; Region: Gly_kinase; pfam02595 410289006139 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 410289006140 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 410289006141 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 410289006142 putative dimer interface [polypeptide binding]; other site 410289006143 active site pocket [active] 410289006144 putative cataytic base [active] 410289006145 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 410289006146 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 410289006147 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 410289006148 homodimer interface [polypeptide binding]; other site 410289006149 substrate-cofactor binding pocket; other site 410289006150 catalytic residue [active] 410289006151 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 410289006152 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 410289006153 cyclase homology domain; Region: CHD; cd07302 410289006154 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 410289006155 nucleotidyl binding site; other site 410289006156 metal binding site [ion binding]; metal-binding site 410289006157 dimer interface [polypeptide binding]; other site 410289006158 multifunctional aminopeptidase A; Provisional; Region: PRK00913 410289006159 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 410289006160 interface (dimer of trimers) [polypeptide binding]; other site 410289006161 Substrate-binding/catalytic site; other site 410289006162 Zn-binding sites [ion binding]; other site 410289006163 short chain dehydrogenase; Validated; Region: PRK05855 410289006164 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 410289006165 classical (c) SDRs; Region: SDR_c; cd05233 410289006166 NAD(P) binding site [chemical binding]; other site 410289006167 active site 410289006168 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 410289006169 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 410289006170 E3 interaction surface; other site 410289006171 lipoyl attachment site [posttranslational modification]; other site 410289006172 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 410289006173 E3 interaction surface; other site 410289006174 lipoyl attachment site [posttranslational modification]; other site 410289006175 e3 binding domain; Region: E3_binding; pfam02817 410289006176 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 410289006177 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 410289006178 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 410289006179 putative NAD(P) binding site [chemical binding]; other site 410289006180 putative active site [active] 410289006181 lipoate-protein ligase B; Provisional; Region: PRK14345 410289006182 lipoyl synthase; Provisional; Region: PRK05481 410289006183 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 410289006184 FeS/SAM binding site; other site 410289006185 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 410289006186 RDD family; Region: RDD; pfam06271 410289006187 glutamine synthetase, type I; Region: GlnA; TIGR00653 410289006188 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 410289006189 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 410289006190 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 410289006191 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 410289006192 metal binding triad; other site 410289006193 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 410289006194 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 410289006195 metal binding triad; other site 410289006196 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 410289006197 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 410289006198 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 410289006199 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 410289006200 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 410289006201 TAP-like protein; Region: Abhydrolase_4; pfam08386 410289006202 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 410289006203 TAP-like protein; Region: Abhydrolase_4; pfam08386 410289006204 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 410289006205 oligomerization interface [polypeptide binding]; other site 410289006206 active site 410289006207 metal binding site [ion binding]; metal-binding site 410289006208 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 410289006209 putative active site; other site 410289006210 putative metal binding residues [ion binding]; other site 410289006211 signature motif; other site 410289006212 putative triphosphate binding site [ion binding]; other site 410289006213 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 410289006214 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl17606 410289006215 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 410289006216 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 410289006217 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 410289006218 RNA/DNA hybrid binding site [nucleotide binding]; other site 410289006219 active site 410289006220 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 410289006221 catalytic core [active] 410289006222 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 410289006223 Putative zinc ribbon domain; Region: DUF164; pfam02591 410289006224 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 410289006225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 410289006226 Uncharacterized conserved protein [Function unknown]; Region: COG0327 410289006227 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 410289006228 hypothetical protein; Provisional; Region: PRK07908 410289006229 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 410289006230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289006231 homodimer interface [polypeptide binding]; other site 410289006232 catalytic residue [active] 410289006233 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 410289006234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 410289006235 active site 410289006236 motif I; other site 410289006237 motif II; other site 410289006238 Low molecular weight phosphatase family; Region: LMWPc; cd00115 410289006239 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 410289006240 active site 410289006241 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 410289006242 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 410289006243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 410289006244 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 410289006245 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 410289006246 dimer interface [polypeptide binding]; other site 410289006247 catalytic triad [active] 410289006248 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 410289006249 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 410289006250 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 410289006251 dimer interface [polypeptide binding]; other site 410289006252 TPP-binding site [chemical binding]; other site 410289006253 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 410289006254 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 410289006255 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 410289006256 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 410289006257 acyl carrier protein; Provisional; Region: acpP; PRK00982 410289006258 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 410289006259 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 410289006260 dimer interface [polypeptide binding]; other site 410289006261 active site 410289006262 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 410289006263 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 410289006264 dimer interface [polypeptide binding]; other site 410289006265 active site 410289006266 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 410289006267 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 410289006268 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 410289006269 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 410289006270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289006271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289006272 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 410289006273 FAD binding domain; Region: FAD_binding_4; pfam01565 410289006274 diacylglycerol kinase; Reviewed; Region: PRK11914 410289006275 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 410289006276 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 410289006277 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 410289006278 Beta-lactamase; Region: Beta-lactamase; pfam00144 410289006279 Methyltransferase domain; Region: Methyltransf_31; pfam13847 410289006280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289006281 S-adenosylmethionine binding site [chemical binding]; other site 410289006282 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 410289006283 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 410289006284 NAD binding site [chemical binding]; other site 410289006285 catalytic Zn binding site [ion binding]; other site 410289006286 substrate binding site [chemical binding]; other site 410289006287 structural Zn binding site [ion binding]; other site 410289006288 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 410289006289 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 410289006290 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 410289006291 putative active site [active] 410289006292 catalytic triad [active] 410289006293 putative dimer interface [polypeptide binding]; other site 410289006294 short chain dehydrogenase; Provisional; Region: PRK05854 410289006295 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 410289006296 putative NAD(P) binding site [chemical binding]; other site 410289006297 active site 410289006298 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 410289006299 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 410289006300 nucleotide binding site [chemical binding]; other site 410289006301 Major Facilitator Superfamily; Region: MFS_1; pfam07690 410289006302 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289006303 Cytochrome P450; Region: p450; cl12078 410289006304 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 410289006305 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289006306 Cytochrome P450; Region: p450; cl12078 410289006307 Septum formation; Region: Septum_form; pfam13845 410289006308 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 410289006309 Predicted membrane protein [Function unknown]; Region: COG2149 410289006310 Domain of unknown function (DUF202); Region: DUF202; pfam02656 410289006311 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289006312 Cytochrome P450; Region: p450; cl12078 410289006313 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 410289006314 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 410289006315 putative active site [active] 410289006316 catalytic site [active] 410289006317 putative metal binding site [ion binding]; other site 410289006318 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 410289006319 FAD binding domain; Region: FAD_binding_4; pfam01565 410289006320 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 410289006321 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 410289006322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 410289006323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 410289006324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 410289006325 dimerization interface [polypeptide binding]; other site 410289006326 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 410289006327 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 410289006328 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 410289006329 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 410289006330 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 410289006331 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 410289006332 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 410289006333 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 410289006334 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 410289006335 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 410289006336 active site residue [active] 410289006337 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 410289006338 active site residue [active] 410289006339 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 410289006340 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 410289006341 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 410289006342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289006343 homodimer interface [polypeptide binding]; other site 410289006344 catalytic residue [active] 410289006345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 410289006346 haloalkane dehalogenase; Provisional; Region: PRK00870 410289006347 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 410289006348 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 410289006349 active site 410289006350 catalytic tetrad [active] 410289006351 heat shock protein 90; Provisional; Region: PRK05218 410289006352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 410289006353 ATP binding site [chemical binding]; other site 410289006354 Mg2+ binding site [ion binding]; other site 410289006355 G-X-G motif; other site 410289006356 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 410289006357 Cutinase; Region: Cutinase; pfam01083 410289006358 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 410289006359 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 410289006360 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 410289006361 Uncharacterized conserved protein [Function unknown]; Region: COG0398 410289006362 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 410289006363 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 410289006364 Uncharacterized conserved protein [Function unknown]; Region: COG2442 410289006365 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 410289006366 DNA binding site [nucleotide binding] 410289006367 active site 410289006368 Int/Topo IB signature motif; other site 410289006369 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 410289006370 DNA binding residues [nucleotide binding] 410289006371 Family description; Region: UvrD_C_2; pfam13538 410289006372 Uncharacterized conserved protein [Function unknown]; Region: COG2128 410289006373 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 410289006374 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 410289006375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289006376 putative PBP binding loops; other site 410289006377 ABC-ATPase subunit interface; other site 410289006378 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 410289006379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289006380 dimer interface [polypeptide binding]; other site 410289006381 conserved gate region; other site 410289006382 putative PBP binding loops; other site 410289006383 ABC-ATPase subunit interface; other site 410289006384 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 410289006385 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 410289006386 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 410289006387 Ligand Binding Site [chemical binding]; other site 410289006388 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 410289006389 Ligand Binding Site [chemical binding]; other site 410289006390 amino acid transporter; Region: 2A0306; TIGR00909 410289006391 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 410289006392 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 410289006393 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 410289006394 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 410289006395 catalytic residue [active] 410289006396 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 410289006397 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 410289006398 Amidinotransferase; Region: Amidinotransf; pfam02274 410289006399 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 410289006400 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 410289006401 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 410289006402 putative DNA binding site [nucleotide binding]; other site 410289006403 putative Zn2+ binding site [ion binding]; other site 410289006404 AsnC family; Region: AsnC_trans_reg; pfam01037 410289006405 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 410289006406 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 410289006407 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 410289006408 Walker A/P-loop; other site 410289006409 ATP binding site [chemical binding]; other site 410289006410 Q-loop/lid; other site 410289006411 ABC transporter signature motif; other site 410289006412 Walker B; other site 410289006413 D-loop; other site 410289006414 H-loop/switch region; other site 410289006415 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 410289006416 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 410289006417 Walker A/P-loop; other site 410289006418 ATP binding site [chemical binding]; other site 410289006419 Q-loop/lid; other site 410289006420 ABC transporter signature motif; other site 410289006421 Walker B; other site 410289006422 D-loop; other site 410289006423 H-loop/switch region; other site 410289006424 MarR family; Region: MarR; pfam01047 410289006425 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 410289006426 PE family; Region: PE; pfam00934 410289006427 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 410289006428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289006429 putative substrate translocation pore; other site 410289006430 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 410289006431 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 410289006432 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 410289006433 malate dehydrogenase; Provisional; Region: PRK13529 410289006434 Malic enzyme, N-terminal domain; Region: malic; pfam00390 410289006435 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 410289006436 NAD(P) binding site [chemical binding]; other site 410289006437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289006438 Major Facilitator Superfamily; Region: MFS_1; pfam07690 410289006439 putative substrate translocation pore; other site 410289006440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289006441 putative substrate translocation pore; other site 410289006442 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 410289006443 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 410289006444 dimer interface [polypeptide binding]; other site 410289006445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289006446 catalytic residue [active] 410289006447 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 410289006448 serine O-acetyltransferase; Region: cysE; TIGR01172 410289006449 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 410289006450 trimer interface [polypeptide binding]; other site 410289006451 active site 410289006452 substrate binding site [chemical binding]; other site 410289006453 CoA binding site [chemical binding]; other site 410289006454 hypothetical protein; Provisional; Region: PRK14851 410289006455 hypothetical protein; Validated; Region: PRK08223 410289006456 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 410289006457 ATP binding site [chemical binding]; other site 410289006458 substrate interface [chemical binding]; other site 410289006459 MMPL family; Region: MMPL; pfam03176 410289006460 MMPL family; Region: MMPL; pfam03176 410289006461 Transport protein; Region: actII; TIGR00833 410289006462 PE family; Region: PE; pfam00934 410289006463 DNA primase; Validated; Region: dnaG; PRK05667 410289006464 CHC2 zinc finger; Region: zf-CHC2; pfam01807 410289006465 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 410289006466 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 410289006467 active site 410289006468 metal binding site [ion binding]; metal-binding site 410289006469 interdomain interaction site; other site 410289006470 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 410289006471 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 410289006472 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 410289006473 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 410289006474 Zn2+ binding site [ion binding]; other site 410289006475 Mg2+ binding site [ion binding]; other site 410289006476 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 410289006477 Repair protein; Region: Repair_PSII; pfam04536 410289006478 Proteins of 100 residues with WXG; Region: WXG100; cl02005 410289006479 PPE family; Region: PPE; pfam00823 410289006480 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289006481 PPE family; Region: PPE; pfam00823 410289006482 RD5, 8963 bp. Region of Difference RD5, deleted region in Mycobacterium bovis BCG Pasteur (position 2603164..2603165) and Mycobacterium bovis AF2122/97 (position 2603664..2603665) compared to Mycobacterium tuberculosis H37Rv2 (position: 2626068..2635030). Removes genes Rv2347c-Rv2352c and truncates genes Rv2346c and Rv2353c. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, additional recombination events occurred: -1-the loss of a copy of IS6110 which leads to the loss of Rv2354 and Rv2355. -2- Recombination between PPE39(Rv2353c) and PPE40(Rv2356c) resulting, for Mycobacterium bovis AF2122/97, in two genes, PPE71 and PPE40, and for Mycobacterium bovis BCG Pasteur in only one gene, PPE71 410289006483 N-RD5, 3298 bp. Region of Difference N-RD5, deleted region in Mycobacterium bovis BCG Pasteur (position 2603740..2603741) and Mycobacterium bovis AF2122/97 (position 2604210..2604211) compared to Mycobacterium tuberculosis H37Rv2 (position: 2635577..2638874). In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, additional recombination events occurred: -1-the loss of a copy of IS6110 which lead to the loss of Rv2354 and Rv2355. -2- Recombination between PPE39 and PPE40 resulting, in Mycobacterium bovis AF2122/97, in two genes, PPE71 and PPE40. In Mycobacterium bovis BCG Pasteur, there has been a 2579bp bp deletion (position 2604022..2604023) equivalent to M. bovis position 2604493..2607071, this has resulted in an in-frame fusion of the 5'-end of PPE40 with the 3'-end of PPE71 probably due to a homologous recombination event between codons 68 and 174 of PPE40 as the PPE40 and PPE71 genes have identical 5'-ends (first 535 bp) 410289006484 NN-RD5, 2579 bp. Region of Difference NN-RD5. Compared to Mycobacterium bovis, there has been a 2579bp deletion (position 2604022..2604023) equivalent to M. bovis position 2604493..2607071, this has resulted in an in-frame fusion of the 5'-end of PPE40 with the 3'-end of PPE71 probably due to a homologous recombination event between codons 68 and 174 of PPE40 as the PPE40 and PPE71 genes have identical 5'-ends (first 535 bp). Differs from Mb2376c (PPE71) by extra 11aa, insertion of A at position 68 due to 3bp insertion (present in PPE40) and STNVGSGNIG at position 307 due to 30 bp insertion. M. bovis BCG Pasteur thus has three copies of tandem repeat STNVGSGNIG compared to two in Mb2376c. The 3'-end of PPE71 of M. bovis BCG Pasteur has also been truncated as a result of the same deletion described in Mycobacterium bovis, 8963 bp deletion (RD5) 410289006485 glycyl-tRNA synthetase; Provisional; Region: PRK04173 410289006486 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 410289006487 motif 1; other site 410289006488 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 410289006489 active site 410289006490 motif 2; other site 410289006491 motif 3; other site 410289006492 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 410289006493 anticodon binding site; other site 410289006494 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 410289006495 dimerization interface [polypeptide binding]; other site 410289006496 putative DNA binding site [nucleotide binding]; other site 410289006497 putative Zn2+ binding site [ion binding]; other site 410289006498 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 410289006499 metal binding site 2 [ion binding]; metal-binding site 410289006500 putative DNA binding helix; other site 410289006501 metal binding site 1 [ion binding]; metal-binding site 410289006502 dimer interface [polypeptide binding]; other site 410289006503 structural Zn2+ binding site [ion binding]; other site 410289006504 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 410289006505 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 410289006506 catalytic residue [active] 410289006507 putative FPP diphosphate binding site; other site 410289006508 putative FPP binding hydrophobic cleft; other site 410289006509 dimer interface [polypeptide binding]; other site 410289006510 putative IPP diphosphate binding site; other site 410289006511 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 410289006512 Recombination protein O N terminal; Region: RecO_N; pfam11967 410289006513 Recombination protein O C terminal; Region: RecO_C; pfam02565 410289006514 amidase; Provisional; Region: PRK06061 410289006515 Amidase; Region: Amidase; pfam01425 410289006516 GTPase Era; Reviewed; Region: era; PRK00089 410289006517 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 410289006518 G1 box; other site 410289006519 GTP/Mg2+ binding site [chemical binding]; other site 410289006520 Switch I region; other site 410289006521 G2 box; other site 410289006522 Switch II region; other site 410289006523 G3 box; other site 410289006524 G4 box; other site 410289006525 G5 box; other site 410289006526 KH domain; Region: KH_2; pfam07650 410289006527 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 410289006528 Domain of unknown function DUF21; Region: DUF21; pfam01595 410289006529 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 410289006530 Transporter associated domain; Region: CorC_HlyC; smart01091 410289006531 metal-binding heat shock protein; Provisional; Region: PRK00016 410289006532 K homology RNA-binding domain; Region: KH; smart00322 410289006533 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 410289006534 PhoH-like protein; Region: PhoH; pfam02562 410289006535 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 410289006536 PE family; Region: PE; pfam00934 410289006537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 410289006538 RNA methyltransferase, RsmE family; Region: TIGR00046 410289006539 chaperone protein DnaJ; Provisional; Region: PRK14278 410289006540 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 410289006541 HSP70 interaction site [polypeptide binding]; other site 410289006542 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 410289006543 Zn binding sites [ion binding]; other site 410289006544 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 410289006545 dimer interface [polypeptide binding]; other site 410289006546 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 410289006547 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 410289006548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 410289006549 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 410289006550 Condensation domain; Region: Condensation; pfam00668 410289006551 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 410289006552 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 410289006553 acyl-activating enzyme (AAE) consensus motif; other site 410289006554 AMP binding site [chemical binding]; other site 410289006555 Condensation domain; Region: Condensation; pfam00668 410289006556 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 410289006557 Condensation domain; Region: Condensation; pfam00668 410289006558 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 410289006559 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 410289006560 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 410289006561 acyl-activating enzyme (AAE) consensus motif; other site 410289006562 AMP binding site [chemical binding]; other site 410289006563 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 410289006564 Condensation domain; Region: Condensation; pfam00668 410289006565 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 410289006566 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 410289006567 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289006568 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 410289006569 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 410289006570 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 410289006571 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 410289006572 NADP binding site [chemical binding]; other site 410289006573 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 410289006574 active site 410289006575 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289006576 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289006577 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 410289006578 active site 410289006579 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 410289006580 Condensation domain; Region: Condensation; pfam00668 410289006581 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 410289006582 Nonribosomal peptide synthase; Region: NRPS; pfam08415 410289006583 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 410289006584 acyl-activating enzyme (AAE) consensus motif; other site 410289006585 AMP binding site [chemical binding]; other site 410289006586 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 410289006587 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 410289006588 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 410289006589 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 410289006590 acyl-activating enzyme (AAE) consensus motif; other site 410289006591 active site 410289006592 AMP binding site [chemical binding]; other site 410289006593 substrate binding site [chemical binding]; other site 410289006594 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 410289006595 salicylate synthase MbtI; Reviewed; Region: PRK07912 410289006596 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 410289006597 Predicted permease [General function prediction only]; Region: COG3329 410289006598 coproporphyrinogen III oxidase; Validated; Region: PRK05628 410289006599 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 410289006600 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 410289006601 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 410289006602 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 410289006603 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 410289006604 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 410289006605 Active Sites [active] 410289006606 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 410289006607 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 410289006608 putative active site [active] 410289006609 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 410289006610 putative active site [active] 410289006611 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 410289006612 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 410289006613 OPT oligopeptide transporter protein; Region: OPT; cl14607 410289006614 OPT oligopeptide transporter protein; Region: OPT; cl14607 410289006615 PE family; Region: PE; pfam00934 410289006616 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 410289006617 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 410289006618 Walker A/P-loop; other site 410289006619 ATP binding site [chemical binding]; other site 410289006620 Q-loop/lid; other site 410289006621 ABC transporter signature motif; other site 410289006622 Walker B; other site 410289006623 D-loop; other site 410289006624 H-loop/switch region; other site 410289006625 sulfate transport protein; Provisional; Region: cysT; CHL00187 410289006626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289006627 dimer interface [polypeptide binding]; other site 410289006628 conserved gate region; other site 410289006629 putative PBP binding loops; other site 410289006630 ABC-ATPase subunit interface; other site 410289006631 sulfate transport protein; Provisional; Region: cysT; CHL00187 410289006632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289006633 dimer interface [polypeptide binding]; other site 410289006634 conserved gate region; other site 410289006635 putative PBP binding loops; other site 410289006636 ABC-ATPase subunit interface; other site 410289006637 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 410289006638 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 410289006639 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 410289006640 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 410289006641 PknH-like extracellular domain; Region: PknH_C; pfam14032 410289006642 GTP-binding protein LepA; Provisional; Region: PRK05433 410289006643 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 410289006644 G1 box; other site 410289006645 putative GEF interaction site [polypeptide binding]; other site 410289006646 GTP/Mg2+ binding site [chemical binding]; other site 410289006647 Switch I region; other site 410289006648 G2 box; other site 410289006649 G3 box; other site 410289006650 Switch II region; other site 410289006651 G4 box; other site 410289006652 G5 box; other site 410289006653 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 410289006654 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 410289006655 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 410289006656 PemK-like protein; Region: PemK; pfam02452 410289006657 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 410289006658 FOG: CBS domain [General function prediction only]; Region: COG0517 410289006659 ribonuclease Z; Reviewed; Region: PRK00055 410289006660 PE family; Region: PE; pfam00934 410289006661 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 410289006662 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 410289006663 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 410289006664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 410289006665 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 410289006666 Uncharacterized conserved protein [Function unknown]; Region: COG2308 410289006667 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 410289006668 hypothetical protein; Reviewed; Region: PRK07914 410289006669 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 410289006670 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 410289006671 Competence protein; Region: Competence; pfam03772 410289006672 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 410289006673 Helix-hairpin-helix motif; Region: HHH; pfam00633 410289006674 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 410289006675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 410289006676 Coenzyme A binding pocket [chemical binding]; other site 410289006677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 410289006678 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 410289006679 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 410289006680 active site 410289006681 catalytic triad [active] 410289006682 oxyanion hole [active] 410289006683 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 410289006684 catalytic core [active] 410289006685 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 410289006686 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 410289006687 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 410289006688 active site 410289006689 (T/H)XGH motif; other site 410289006690 Methyltransferase domain; Region: Methyltransf_23; pfam13489 410289006691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289006692 S-adenosylmethionine binding site [chemical binding]; other site 410289006693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 410289006694 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 410289006695 Transposase; Region: DEDD_Tnp_IS110; pfam01548 410289006696 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 410289006697 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 410289006698 metal ion-dependent adhesion site (MIDAS); other site 410289006699 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 410289006700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289006701 Walker A motif; other site 410289006702 ATP binding site [chemical binding]; other site 410289006703 Walker B motif; other site 410289006704 arginine finger; other site 410289006705 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 410289006706 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 410289006707 putative catalytic cysteine [active] 410289006710 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 410289006711 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 410289006712 dimer interface [polypeptide binding]; other site 410289006713 decamer (pentamer of dimers) interface [polypeptide binding]; other site 410289006714 catalytic triad [active] 410289006715 peroxidatic and resolving cysteines [active] 410289006716 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 410289006717 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 410289006718 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289006719 PPE family; Region: PPE; pfam00823 410289006720 PE family; Region: PE; pfam00934 410289006721 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 410289006722 Mechanosensitive ion channel; Region: MS_channel; pfam00924 410289006723 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 410289006724 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 410289006725 ligand binding site [chemical binding]; other site 410289006726 flexible hinge region; other site 410289006727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 410289006728 dimerization interface [polypeptide binding]; other site 410289006729 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 410289006730 cyclase homology domain; Region: CHD; cd07302 410289006731 nucleotidyl binding site; other site 410289006732 metal binding site [ion binding]; metal-binding site 410289006733 dimer interface [polypeptide binding]; other site 410289006734 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 410289006735 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 410289006736 substrate binding site [chemical binding]; other site 410289006737 dimer interface [polypeptide binding]; other site 410289006738 ATP binding site [chemical binding]; other site 410289006739 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 410289006740 NAD synthetase; Reviewed; Region: nadE; PRK02628 410289006741 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 410289006742 multimer interface [polypeptide binding]; other site 410289006743 active site 410289006744 catalytic triad [active] 410289006745 protein interface 1 [polypeptide binding]; other site 410289006746 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 410289006747 homodimer interface [polypeptide binding]; other site 410289006748 NAD binding pocket [chemical binding]; other site 410289006749 ATP binding pocket [chemical binding]; other site 410289006750 Mg binding site [ion binding]; other site 410289006751 active-site loop [active] 410289006752 gamma-glutamyl kinase; Provisional; Region: PRK05429 410289006753 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 410289006754 nucleotide binding site [chemical binding]; other site 410289006755 homotetrameric interface [polypeptide binding]; other site 410289006756 putative phosphate binding site [ion binding]; other site 410289006757 putative allosteric binding site; other site 410289006758 PUA domain; Region: PUA; pfam01472 410289006759 GTPase CgtA; Reviewed; Region: obgE; PRK12296 410289006760 GTP1/OBG; Region: GTP1_OBG; pfam01018 410289006761 Obg GTPase; Region: Obg; cd01898 410289006762 G1 box; other site 410289006763 GTP/Mg2+ binding site [chemical binding]; other site 410289006764 Switch I region; other site 410289006765 G2 box; other site 410289006766 G3 box; other site 410289006767 Switch II region; other site 410289006768 G4 box; other site 410289006769 G5 box; other site 410289006770 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 410289006771 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 410289006772 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 410289006773 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 410289006774 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 410289006775 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 410289006776 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 410289006777 homodimer interface [polypeptide binding]; other site 410289006778 oligonucleotide binding site [chemical binding]; other site 410289006779 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 410289006780 active site 410289006781 multimer interface [polypeptide binding]; other site 410289006782 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 410289006783 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 410289006784 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 410289006785 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 410289006786 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 410289006787 active site 410289006788 HIGH motif; other site 410289006789 nucleotide binding site [chemical binding]; other site 410289006790 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 410289006791 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 410289006792 active site 410289006793 KMSKS motif; other site 410289006794 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 410289006795 tRNA binding surface [nucleotide binding]; other site 410289006796 anticodon binding site; other site 410289006797 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 410289006798 Uncharacterized conserved protein [Function unknown]; Region: COG3268 410289006799 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 410289006800 NAD(P) binding pocket [chemical binding]; other site 410289006801 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 410289006802 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 410289006803 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 410289006804 GTP binding site; other site 410289006805 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 410289006806 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 410289006807 TPP-binding site [chemical binding]; other site 410289006808 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 410289006809 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 410289006810 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 410289006811 dimer interface [polypeptide binding]; other site 410289006812 PYR/PP interface [polypeptide binding]; other site 410289006813 TPP binding site [chemical binding]; other site 410289006814 substrate binding site [chemical binding]; other site 410289006815 Major Facilitator Superfamily; Region: MFS_1; pfam07690 410289006816 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 410289006817 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 410289006818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289006819 Walker A motif; other site 410289006820 ATP binding site [chemical binding]; other site 410289006821 Walker B motif; other site 410289006822 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 410289006823 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 410289006824 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 410289006825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289006826 Major Facilitator Superfamily; Region: MFS_1; pfam07690 410289006827 putative substrate translocation pore; other site 410289006828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289006829 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 410289006830 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 410289006831 oligomer interface [polypeptide binding]; other site 410289006832 active site residues [active] 410289006833 Clp protease; Region: CLP_protease; pfam00574 410289006834 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 410289006835 oligomer interface [polypeptide binding]; other site 410289006836 active site residues [active] 410289006837 trigger factor; Provisional; Region: tig; PRK01490 410289006838 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 410289006839 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 410289006840 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 410289006841 Beta-lactamase; Region: Beta-lactamase; pfam00144 410289006842 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 410289006843 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 410289006844 putative DNA binding site [nucleotide binding]; other site 410289006845 catalytic residue [active] 410289006846 putative H2TH interface [polypeptide binding]; other site 410289006847 putative catalytic residues [active] 410289006848 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 410289006849 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 410289006850 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 410289006851 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 410289006852 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 410289006853 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 410289006854 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 410289006855 Zn binding site [ion binding]; other site 410289006856 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 410289006857 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289006858 active site 410289006859 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 410289006860 apolar tunnel; other site 410289006861 heme binding site [chemical binding]; other site 410289006862 dimerization interface [polypeptide binding]; other site 410289006863 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 410289006864 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 410289006865 active site 410289006866 catalytic site [active] 410289006867 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 410289006868 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 410289006869 active site 410289006870 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 410289006871 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 410289006872 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 410289006873 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 410289006874 ABC transporter; Region: ABC_tran_2; pfam12848 410289006875 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 410289006876 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 410289006877 dimer interface [polypeptide binding]; other site 410289006878 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 410289006879 ssDNA binding site [nucleotide binding]; other site 410289006880 tetramer (dimer of dimers) interface [polypeptide binding]; other site 410289006881 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 410289006882 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 410289006883 putative acyl-acceptor binding pocket; other site 410289006884 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 410289006885 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 410289006886 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 410289006887 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 410289006888 putative acyl-acceptor binding pocket; other site 410289006889 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 410289006890 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 410289006891 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 410289006892 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 410289006893 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 410289006894 enoyl-CoA hydratase; Provisional; Region: PRK05870 410289006895 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289006896 substrate binding site [chemical binding]; other site 410289006897 oxyanion hole (OAH) forming residues; other site 410289006898 trimer interface [polypeptide binding]; other site 410289006899 PE family; Region: PE; pfam00934 410289006900 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 410289006901 cyclase homology domain; Region: CHD; cd07302 410289006902 nucleotidyl binding site; other site 410289006903 metal binding site [ion binding]; metal-binding site 410289006904 dimer interface [polypeptide binding]; other site 410289006905 Predicted ATPase [General function prediction only]; Region: COG3903 410289006906 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 410289006907 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 410289006908 DNA binding residues [nucleotide binding] 410289006909 dimerization interface [polypeptide binding]; other site 410289006910 PE family; Region: PE; pfam00934 410289006911 TIGR00725 family protein; Region: TIGR00725 410289006912 thymidylate synthase; Provisional; Region: thyA; PRK00956 410289006913 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 410289006914 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 410289006915 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 410289006916 E3 interaction surface; other site 410289006917 lipoyl attachment site [posttranslational modification]; other site 410289006918 e3 binding domain; Region: E3_binding; pfam02817 410289006919 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 410289006920 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 410289006921 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 410289006922 alpha subunit interface [polypeptide binding]; other site 410289006923 TPP binding site [chemical binding]; other site 410289006924 heterodimer interface [polypeptide binding]; other site 410289006925 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 410289006926 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 410289006927 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 410289006928 tetramer interface [polypeptide binding]; other site 410289006929 TPP-binding site [chemical binding]; other site 410289006930 heterodimer interface [polypeptide binding]; other site 410289006931 phosphorylation loop region [posttranslational modification] 410289006932 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 410289006933 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 410289006934 putative active site [active] 410289006935 putative catalytic site [active] 410289006936 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289006937 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289006938 active site 410289006939 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 410289006940 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 410289006941 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 410289006942 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 410289006943 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 410289006944 carboxyltransferase (CT) interaction site; other site 410289006945 biotinylation site [posttranslational modification]; other site 410289006946 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 410289006947 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 410289006948 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 410289006949 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 410289006950 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 410289006951 AMP-binding domain protein; Validated; Region: PRK08315 410289006952 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289006953 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 410289006954 acyl-activating enzyme (AAE) consensus motif; other site 410289006955 acyl-activating enzyme (AAE) consensus motif; other site 410289006956 putative AMP binding site [chemical binding]; other site 410289006957 putative active site [active] 410289006958 putative CoA binding site [chemical binding]; other site 410289006959 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289006960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289006961 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 410289006962 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 410289006963 classical (c) SDRs; Region: SDR_c; cd05233 410289006964 NAD(P) binding site [chemical binding]; other site 410289006965 active site 410289006966 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 410289006967 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 410289006968 catalytic site [active] 410289006969 putative active site [active] 410289006970 putative substrate binding site [chemical binding]; other site 410289006971 dimer interface [polypeptide binding]; other site 410289006972 Transposase, Mutator family; Region: Transposase_mut; pfam00872 410289006973 MULE transposase domain; Region: MULE; pfam10551 410289006974 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 410289006975 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 410289006976 non-specific DNA binding site [nucleotide binding]; other site 410289006977 salt bridge; other site 410289006978 sequence-specific DNA binding site [nucleotide binding]; other site 410289006979 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 410289006980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 410289006981 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 410289006982 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 410289006983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 410289006984 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 410289006985 PE family; Region: PE; pfam00934 410289006986 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 410289006987 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 410289006988 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 410289006989 catalytic triad [active] 410289006990 hypothetical protein; Provisional; Region: PRK07907 410289006991 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 410289006992 active site 410289006993 metal binding site [ion binding]; metal-binding site 410289006994 dimer interface [polypeptide binding]; other site 410289006995 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 410289006996 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 410289006997 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 410289006998 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 410289006999 phosphate binding site [ion binding]; other site 410289007000 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 410289007001 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 410289007002 putative active site [active] 410289007003 putative catalytic site [active] 410289007004 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 410289007005 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 410289007006 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 410289007007 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 410289007008 putative NAD(P) binding site [chemical binding]; other site 410289007009 active site 410289007010 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 410289007011 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 410289007012 active site 410289007013 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 410289007014 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 410289007015 putative active site [active] 410289007016 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 410289007017 Mrr N-terminal domain; Region: Mrr_N; pfam14338 410289007018 Restriction endonuclease; Region: Mrr_cat; pfam04471 410289007019 ERCC4 domain; Region: ERCC4; pfam02732 410289007020 Lsr2; Region: Lsr2; pfam11774 410289007021 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 410289007022 putative active site [active] 410289007023 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 410289007024 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 410289007025 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 410289007026 catalytic residue [active] 410289007027 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 410289007028 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 410289007029 putative RNA binding site [nucleotide binding]; other site 410289007030 elongation factor P; Validated; Region: PRK00529 410289007031 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 410289007032 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 410289007033 RNA binding site [nucleotide binding]; other site 410289007034 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 410289007035 RNA binding site [nucleotide binding]; other site 410289007036 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 410289007037 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 410289007038 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 410289007039 active site 410289007040 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 410289007041 Dehydroquinase class II; Region: DHquinase_II; pfam01220 410289007042 trimer interface [polypeptide binding]; other site 410289007043 active site 410289007044 dimer interface [polypeptide binding]; other site 410289007045 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 410289007046 active site 410289007047 dimer interface [polypeptide binding]; other site 410289007048 metal binding site [ion binding]; metal-binding site 410289007049 shikimate kinase; Reviewed; Region: aroK; PRK00131 410289007050 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 410289007051 ADP binding site [chemical binding]; other site 410289007052 magnesium binding site [ion binding]; other site 410289007053 putative shikimate binding site; other site 410289007054 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 410289007055 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 410289007056 Tetramer interface [polypeptide binding]; other site 410289007057 active site 410289007058 FMN-binding site [chemical binding]; other site 410289007059 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 410289007060 I-RD05, 656 bp. Region of Difference I-RD05, inserted region in Mycobacterium bovis BCG Pasteur (position 2830679..2831334, 656bp) and Mycobacterium bovis AF2122/97 (position 2833680..2834335, 656bp) compared to Mycobacterium tuberculosis H37Rv2 (position: 2866882..2866883). Leads to extra gene, lprR, similar to adjacent lppA and lppB 410289007061 digalactosyldiacylglycerol synthase; Region: PLN02846 410289007062 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 410289007063 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 410289007064 putative active site [active] 410289007065 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 410289007066 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 410289007067 oligomeric interface; other site 410289007068 putative active site [active] 410289007069 homodimer interface [polypeptide binding]; other site 410289007070 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 410289007071 putative active site [active] 410289007072 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 410289007073 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 410289007074 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 410289007075 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 410289007076 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 410289007077 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 410289007078 NAD(P) binding site [chemical binding]; other site 410289007079 shikimate binding site; other site 410289007080 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 410289007081 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 410289007082 dimerization interface [polypeptide binding]; other site 410289007083 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 410289007084 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 410289007085 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 410289007086 motif 1; other site 410289007087 active site 410289007088 motif 2; other site 410289007089 motif 3; other site 410289007090 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 410289007091 DHHA1 domain; Region: DHHA1; pfam02272 410289007092 Uncharacterized conserved protein [Function unknown]; Region: COG0432 410289007093 recombination factor protein RarA; Reviewed; Region: PRK13342 410289007094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289007095 Walker A motif; other site 410289007096 ATP binding site [chemical binding]; other site 410289007097 Walker B motif; other site 410289007098 arginine finger; other site 410289007099 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 410289007100 Predicted integral membrane protein [Function unknown]; Region: COG5473 410289007101 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 410289007102 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 410289007103 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 410289007104 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 410289007105 Walker A/P-loop; other site 410289007106 ATP binding site [chemical binding]; other site 410289007107 Q-loop/lid; other site 410289007108 ABC transporter signature motif; other site 410289007109 Walker B; other site 410289007110 D-loop; other site 410289007111 H-loop/switch region; other site 410289007112 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 410289007113 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 410289007114 ligand binding site [chemical binding]; other site 410289007115 flexible hinge region; other site 410289007116 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 410289007117 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 410289007118 ligand binding site [chemical binding]; other site 410289007119 flexible hinge region; other site 410289007120 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 410289007121 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 410289007122 active site 410289007123 nucleophile elbow; other site 410289007124 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 410289007125 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 410289007126 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 410289007127 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 410289007128 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 410289007129 Uncharacterized conserved protein [Function unknown]; Region: COG2308 410289007130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 410289007131 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 410289007132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 410289007133 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 410289007134 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 410289007135 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 410289007136 Transglutaminase/protease-like homologues; Region: TGc; smart00460 410289007137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 410289007138 Predicted membrane protein [Function unknown]; Region: COG4129 410289007139 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 410289007140 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 410289007141 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 410289007142 dimer interface [polypeptide binding]; other site 410289007143 anticodon binding site; other site 410289007144 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 410289007145 homodimer interface [polypeptide binding]; other site 410289007146 motif 1; other site 410289007147 active site 410289007148 motif 2; other site 410289007149 GAD domain; Region: GAD; pfam02938 410289007150 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 410289007151 active site 410289007152 motif 3; other site 410289007153 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 410289007154 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 410289007155 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 410289007156 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 410289007157 putative hydrophobic ligand binding site [chemical binding]; other site 410289007158 protein interface [polypeptide binding]; other site 410289007159 gate; other site 410289007160 Predicted metalloprotease [General function prediction only]; Region: COG2321 410289007161 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 410289007162 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 410289007163 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 410289007164 active site 410289007165 metal binding site [ion binding]; metal-binding site 410289007166 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 410289007167 haloalkane dehalogenase; Provisional; Region: PRK03592 410289007168 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 410289007169 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 410289007170 dimer interface [polypeptide binding]; other site 410289007171 motif 1; other site 410289007172 active site 410289007173 motif 2; other site 410289007174 motif 3; other site 410289007175 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 410289007176 anticodon binding site; other site 410289007177 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 410289007178 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 410289007179 active site 410289007180 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 410289007181 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 410289007182 Zn2+ binding site [ion binding]; other site 410289007183 Mg2+ binding site [ion binding]; other site 410289007184 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 410289007185 synthetase active site [active] 410289007186 NTP binding site [chemical binding]; other site 410289007187 metal binding site [ion binding]; metal-binding site 410289007188 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 410289007189 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 410289007190 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 410289007191 active site 410289007192 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 410289007193 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 410289007194 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 410289007195 Protein export membrane protein; Region: SecD_SecF; pfam02355 410289007196 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 410289007197 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 410289007198 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 410289007199 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 410289007200 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 410289007201 inhibitor-cofactor binding pocket; inhibition site 410289007202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289007203 catalytic residue [active] 410289007204 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 410289007205 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289007206 acyl-activating enzyme (AAE) consensus motif; other site 410289007207 AMP binding site [chemical binding]; other site 410289007208 active site 410289007209 CoA binding site [chemical binding]; other site 410289007210 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 410289007211 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 410289007212 putative NAD(P) binding site [chemical binding]; other site 410289007213 active site 410289007214 putative substrate binding site [chemical binding]; other site 410289007215 PE family; Region: PE; pfam00934 410289007216 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 410289007217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289007218 Walker A motif; other site 410289007219 ATP binding site [chemical binding]; other site 410289007220 Walker B motif; other site 410289007221 arginine finger; other site 410289007222 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 410289007223 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 410289007224 RuvA N terminal domain; Region: RuvA_N; pfam01330 410289007225 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 410289007226 active site 410289007227 putative DNA-binding cleft [nucleotide binding]; other site 410289007228 dimer interface [polypeptide binding]; other site 410289007229 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 410289007230 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 410289007231 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 410289007232 putative active site [active] 410289007233 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 410289007234 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 410289007235 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 410289007236 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 410289007237 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 410289007238 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 410289007239 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 410289007240 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 410289007241 hypothetical protein; Validated; Region: PRK00110 410289007242 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 410289007243 predicted active site [active] 410289007244 catalytic triad [active] 410289007245 acyl-CoA thioesterase II; Region: tesB; TIGR00189 410289007246 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 410289007247 active site 410289007248 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 410289007249 catalytic triad [active] 410289007250 dimer interface [polypeptide binding]; other site 410289007251 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 410289007252 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 410289007253 active site 410289007254 multimer interface [polypeptide binding]; other site 410289007255 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 410289007256 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 410289007257 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 410289007258 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289007259 PPE family; Region: PPE; pfam00823 410289007260 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289007261 PE-PPE domain; Region: PE-PPE; pfam08237 410289007262 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 410289007263 nudix motif; other site 410289007264 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 410289007265 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 410289007266 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 410289007267 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 410289007268 putative acyl-acceptor binding pocket; other site 410289007269 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 410289007270 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 410289007271 nucleotide binding site/active site [active] 410289007272 HIT family signature motif; other site 410289007273 catalytic residue [active] 410289007274 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 410289007275 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 410289007276 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 410289007277 active site 410289007278 dimer interface [polypeptide binding]; other site 410289007279 motif 1; other site 410289007280 motif 2; other site 410289007281 motif 3; other site 410289007282 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 410289007283 anticodon binding site; other site 410289007284 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 410289007285 phosphate binding site [ion binding]; other site 410289007286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 410289007287 Predicted transcriptional regulator [Transcription]; Region: COG2345 410289007288 Helix-turn-helix domain; Region: HTH_20; pfam12840 410289007289 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 410289007290 Predicted transcriptional regulator [Transcription]; Region: COG2345 410289007291 Helix-turn-helix domain; Region: HTH_20; pfam12840 410289007292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289007293 S-adenosylmethionine binding site [chemical binding]; other site 410289007294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 410289007295 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 410289007296 Ligand Binding Site [chemical binding]; other site 410289007297 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 410289007298 Ligand Binding Site [chemical binding]; other site 410289007299 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 410289007300 Ligand Binding Site [chemical binding]; other site 410289007301 Universal stress protein family; Region: Usp; pfam00582 410289007302 Ligand Binding Site [chemical binding]; other site 410289007303 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 410289007304 active site 410289007305 Peptidase family M50; Region: Peptidase_M50; pfam02163 410289007306 putative substrate binding region [chemical binding]; other site 410289007307 FOG: CBS domain [General function prediction only]; Region: COG0517 410289007308 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 410289007309 FOG: CBS domain [General function prediction only]; Region: COG0517 410289007310 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 410289007311 peptide chain release factor 1; Provisional; Region: PRK04011 410289007312 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 410289007313 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 410289007314 hypothetical protein; Reviewed; Region: PRK09588 410289007315 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 410289007316 Hemerythrin-like domain; Region: Hr-like; cd12108 410289007317 Fe binding site [ion binding]; other site 410289007318 PE family; Region: PE; pfam00934 410289007319 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 410289007320 P-loop motif; other site 410289007321 ATP binding site [chemical binding]; other site 410289007322 Chloramphenicol (Cm) binding site [chemical binding]; other site 410289007323 catalytic residue [active] 410289007324 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 410289007325 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 410289007326 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 410289007327 anti sigma factor interaction site; other site 410289007328 regulatory phosphorylation site [posttranslational modification]; other site 410289007329 hypothetical protein; Provisional; Region: PRK02237 410289007330 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 410289007331 Transcriptional regulators [Transcription]; Region: MarR; COG1846 410289007332 putative DNA binding site [nucleotide binding]; other site 410289007333 putative Zn2+ binding site [ion binding]; other site 410289007334 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 410289007335 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 410289007336 putative metal binding site [ion binding]; other site 410289007337 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 410289007338 dimerization interface [polypeptide binding]; other site 410289007339 putative DNA binding site [nucleotide binding]; other site 410289007340 putative Zn2+ binding site [ion binding]; other site 410289007341 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 410289007342 arsenical-resistance protein; Region: acr3; TIGR00832 410289007343 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 410289007344 Low molecular weight phosphatase family; Region: LMWPc; cd00115 410289007345 active site 410289007346 RD11, 10982 bp. Region of Difference RD11, phiRv2, deleted region in Mycobacterium bovis BCG Pasteur (position 2934526..2934527) and Mycobacterium bovis AF2122/97 (position 2937478..2937479) compared to Mycobacterium tuberculosis H37Rv2 (position: 2970017-2980998). Removes genes Rv2645-Rv2659c. The region comprises a copy of IS6110 and the phiRv2 prophage 410289007347 Transposase, Mutator family; Region: Transposase_mut; pfam00872 410289007348 MULE transposase domain; Region: MULE; pfam10551 410289007349 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 410289007350 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 410289007351 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 410289007352 Coenzyme A binding pocket [chemical binding]; other site 410289007353 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 410289007354 hypothetical protein; Provisional; Region: PRK14059 410289007355 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 410289007356 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 410289007357 TAP-like protein; Region: Abhydrolase_4; pfam08386 410289007358 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 410289007359 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 410289007360 SelR domain; Region: SelR; pfam01641 410289007361 Methyltransferase domain; Region: Methyltransf_31; pfam13847 410289007362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289007363 S-adenosylmethionine binding site [chemical binding]; other site 410289007364 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 410289007365 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 410289007366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 410289007367 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 410289007368 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 410289007369 substrate binding site [chemical binding]; other site 410289007370 active site 410289007371 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289007372 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 410289007373 substrate binding site [chemical binding]; other site 410289007374 oxyanion hole (OAH) forming residues; other site 410289007375 trimer interface [polypeptide binding]; other site 410289007376 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 410289007377 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 410289007378 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 410289007379 catalytic site [active] 410289007380 putative active site [active] 410289007381 putative substrate binding site [chemical binding]; other site 410289007382 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 410289007383 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 410289007384 TPP-binding site; other site 410289007385 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 410289007386 PYR/PP interface [polypeptide binding]; other site 410289007387 dimer interface [polypeptide binding]; other site 410289007388 TPP binding site [chemical binding]; other site 410289007389 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 410289007390 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 410289007391 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 410289007392 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 410289007393 transmembrane helices; other site 410289007394 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 410289007395 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 410289007396 transmembrane helices; other site 410289007397 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 410289007398 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 410289007399 Walker A/P-loop; other site 410289007400 ATP binding site [chemical binding]; other site 410289007401 Q-loop/lid; other site 410289007402 ABC transporter signature motif; other site 410289007403 Walker B; other site 410289007404 D-loop; other site 410289007405 H-loop/switch region; other site 410289007406 TRAM domain; Region: TRAM; cl01282 410289007407 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 410289007408 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 410289007409 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 410289007410 TrkA-N domain; Region: TrkA_N; pfam02254 410289007411 TrkA-C domain; Region: TrkA_C; pfam02080 410289007412 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 410289007413 TrkA-N domain; Region: TrkA_N; pfam02254 410289007414 TrkA-C domain; Region: TrkA_C; pfam02080 410289007415 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 410289007416 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 410289007417 generic binding surface II; other site 410289007418 ssDNA binding site; other site 410289007419 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 410289007420 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 410289007421 trimer interface [polypeptide binding]; other site 410289007422 active site 410289007423 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 410289007424 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 410289007425 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 410289007426 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 410289007427 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 410289007428 active site 410289007429 dimerization interface [polypeptide binding]; other site 410289007430 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 410289007431 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 410289007432 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 410289007433 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 410289007434 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 410289007435 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 410289007436 DNA binding residues [nucleotide binding] 410289007437 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 410289007438 homotrimer interaction site [polypeptide binding]; other site 410289007439 putative active site [active] 410289007440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 410289007441 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 410289007442 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 410289007443 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 410289007444 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 410289007445 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 410289007446 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 410289007447 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 410289007448 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 410289007449 DNA binding residues [nucleotide binding] 410289007450 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 410289007451 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 410289007452 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 410289007453 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 410289007454 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 410289007455 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 410289007456 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 410289007457 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 410289007458 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 410289007459 PAC2 family; Region: PAC2; pfam09754 410289007460 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 410289007461 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 410289007462 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 410289007463 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 410289007464 heme-binding site [chemical binding]; other site 410289007465 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 410289007466 ATP cone domain; Region: ATP-cone; pfam03477 410289007467 LysM domain; Region: LysM; pfam01476 410289007468 LexA repressor; Validated; Region: PRK00215 410289007469 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 410289007470 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 410289007471 Catalytic site [active] 410289007472 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 410289007473 LGFP repeat; Region: LGFP; pfam08310 410289007474 LGFP repeat; Region: LGFP; pfam08310 410289007475 LGFP repeat; Region: LGFP; pfam08310 410289007476 LGFP repeat; Region: LGFP; pfam08310 410289007477 LGFP repeat; Region: LGFP; pfam08310 410289007478 Integral membrane protein TerC family; Region: TerC; cl10468 410289007479 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289007480 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289007481 active site 410289007482 GTPases [General function prediction only]; Region: HflX; COG2262 410289007483 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 410289007484 HflX GTPase family; Region: HflX; cd01878 410289007485 G1 box; other site 410289007486 GTP/Mg2+ binding site [chemical binding]; other site 410289007487 Switch I region; other site 410289007488 G2 box; other site 410289007489 G3 box; other site 410289007490 Switch II region; other site 410289007491 G4 box; other site 410289007492 G5 box; other site 410289007493 diaminopimelate epimerase; Region: DapF; TIGR00652 410289007494 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 410289007495 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 410289007496 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 410289007497 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 410289007498 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 410289007499 active site 410289007500 metal binding site [ion binding]; metal-binding site 410289007501 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 410289007502 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 410289007503 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 410289007504 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 410289007505 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 410289007506 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 410289007507 FeS/SAM binding site; other site 410289007508 TRAM domain; Region: TRAM; cl01282 410289007509 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 410289007510 FeS/SAM binding site; other site 410289007511 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 410289007512 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 410289007513 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 410289007514 hexamer interface [polypeptide binding]; other site 410289007515 Walker A motif; other site 410289007516 ATP binding site [chemical binding]; other site 410289007517 Walker B motif; other site 410289007518 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 410289007519 protein-splicing catalytic site; other site 410289007520 thioester formation/cholesterol transfer; other site 410289007521 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 410289007522 recA bacterial DNA recombination protein; Region: RecA; cl17211 410289007523 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 410289007524 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 410289007525 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 410289007526 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 410289007527 Limonene-1,2-epoxide hydrolase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LimA; COG4308 410289007528 similar to PE-PGRS family protein; In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis, deletions of a single base (t-*) leads to frameshifted products PE_PGRS47a (10 aa) and PE_PGRS47b (424 aa), respectively 410289007529 PE family; Region: PE; pfam00934 410289007530 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 410289007531 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 410289007532 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 410289007533 non-specific DNA binding site [nucleotide binding]; other site 410289007534 salt bridge; other site 410289007535 sequence-specific DNA binding site [nucleotide binding]; other site 410289007536 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 410289007537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 410289007538 Coenzyme A binding pocket [chemical binding]; other site 410289007539 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 410289007540 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 410289007541 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 410289007542 Uncharacterized conserved protein [Function unknown]; Region: COG1359 410289007543 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 410289007544 classical (c) SDRs; Region: SDR_c; cd05233 410289007545 NAD(P) binding site [chemical binding]; other site 410289007546 active site 410289007547 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 410289007548 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 410289007549 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 410289007550 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 410289007551 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 410289007552 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 410289007553 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 410289007554 dimer interface [polypeptide binding]; other site 410289007555 active site 410289007556 catalytic residue [active] 410289007557 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 410289007558 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 410289007559 HsdM N-terminal domain; Region: HsdM_N; pfam12161 410289007560 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 410289007561 Methyltransferase domain; Region: Methyltransf_26; pfam13659 410289007562 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 410289007563 putative active site [active] 410289007564 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 410289007565 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 410289007566 putative active site [active] 410289007567 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 410289007568 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 410289007569 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 410289007570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 410289007571 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 410289007572 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 410289007573 folate binding site [chemical binding]; other site 410289007574 NADP+ binding site [chemical binding]; other site 410289007575 thymidylate synthase; Reviewed; Region: thyA; PRK01827 410289007576 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 410289007577 dimerization interface [polypeptide binding]; other site 410289007578 active site 410289007579 Dienelactone hydrolase family; Region: DLH; pfam01738 410289007580 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 410289007581 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 410289007582 classical (c) SDRs; Region: SDR_c; cd05233 410289007583 NAD(P) binding site [chemical binding]; other site 410289007584 active site 410289007585 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289007586 PPE family; Region: PPE; pfam00823 410289007587 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 410289007588 PE family; Region: PE; pfam00934 410289007589 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 410289007590 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289007591 PPE family; Region: PPE; pfam00823 410289007592 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 410289007593 dihydrodipicolinate reductase; Provisional; Region: PRK00048 410289007594 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 410289007595 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 410289007596 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 410289007597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 410289007598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 410289007599 Coenzyme A binding pocket [chemical binding]; other site 410289007600 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 410289007601 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 410289007602 FMN-binding pocket [chemical binding]; other site 410289007603 flavin binding motif; other site 410289007604 phosphate binding motif [ion binding]; other site 410289007605 beta-alpha-beta structure motif; other site 410289007606 NAD binding pocket [chemical binding]; other site 410289007607 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 410289007608 catalytic loop [active] 410289007609 iron binding site [ion binding]; other site 410289007610 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 410289007611 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 410289007612 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 410289007613 hydrophobic ligand binding site; other site 410289007614 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 410289007615 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 410289007616 putative DNA binding site [nucleotide binding]; other site 410289007617 putative Zn2+ binding site [ion binding]; other site 410289007618 AsnC family; Region: AsnC_trans_reg; pfam01037 410289007619 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 410289007620 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 410289007621 NAD binding site [chemical binding]; other site 410289007622 Nitronate monooxygenase; Region: NMO; pfam03060 410289007623 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 410289007624 FMN binding site [chemical binding]; other site 410289007625 substrate binding site [chemical binding]; other site 410289007626 putative catalytic residue [active] 410289007627 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 410289007628 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 410289007629 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 410289007630 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 410289007631 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 410289007632 oligomer interface [polypeptide binding]; other site 410289007633 RNA binding site [nucleotide binding]; other site 410289007634 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 410289007635 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 410289007636 RNase E interface [polypeptide binding]; other site 410289007637 trimer interface [polypeptide binding]; other site 410289007638 active site 410289007639 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 410289007640 putative nucleic acid binding region [nucleotide binding]; other site 410289007641 G-X-X-G motif; other site 410289007642 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 410289007643 RNA binding site [nucleotide binding]; other site 410289007644 domain interface; other site 410289007645 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 410289007646 16S/18S rRNA binding site [nucleotide binding]; other site 410289007647 S13e-L30e interaction site [polypeptide binding]; other site 410289007648 25S rRNA binding site [nucleotide binding]; other site 410289007649 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 410289007650 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 410289007651 active site 410289007652 Riboflavin kinase; Region: Flavokinase; pfam01687 410289007653 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 410289007654 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 410289007655 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 410289007656 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 410289007657 putative DNA binding site [nucleotide binding]; other site 410289007658 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 410289007659 FeoA domain; Region: FeoA; pfam04023 410289007660 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289007661 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289007662 active site 410289007663 lipid-transfer protein; Provisional; Region: PRK08256 410289007664 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 410289007665 active site 410289007666 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 410289007667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 410289007668 Probable transposase; Region: OrfB_IS605; pfam01385 410289007669 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 410289007670 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 410289007671 catalytic residues [active] 410289007672 catalytic nucleophile [active] 410289007673 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 410289007674 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 410289007675 RNA binding site [nucleotide binding]; other site 410289007676 active site 410289007677 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 410289007678 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 410289007679 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 410289007680 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 410289007681 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 410289007682 active site 410289007683 metal binding site [ion binding]; metal-binding site 410289007684 Uncharacterized conserved protein [Function unknown]; Region: COG4717 410289007685 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 410289007686 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 410289007687 Predicted acyl esterases [General function prediction only]; Region: COG2936 410289007688 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 410289007689 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 410289007690 Uncharacterized conserved protein [Function unknown]; Region: COG5586 410289007691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 410289007692 Integrase core domain; Region: rve; pfam00665 410289007693 Helix-turn-helix domain; Region: HTH_28; pfam13518 410289007694 Winged helix-turn helix; Region: HTH_29; pfam13551 410289007695 Integrase core domain; Region: rve; pfam00665 410289007696 Integrase core domain; Region: rve_3; pfam13683 410289007697 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 410289007698 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 410289007699 S-RD06, 4921 bp, Region of Difference S-RD06. The DR region is composed of near-perfect tandem direct repeats of 36 bases pairs (GTCGTCAGACCCAAAACCCCGAGAGGGGACGGAAAC), separated in 2 stretches by the insertion of an IS6110 element inside one copy. In Mycobacterium bovis BCG Pasteur (position 3072633..3077553, 4921bp), it is composed of 49 copies (19.5 and 29.5) , compared to 42 copies (17.5 and 24.5) in Mycobacterium bovis AF (position 3075735..3080138, 4404bp) and 42 copies (18.5 and 23.5) in Mycobacterium tuberculosis strain H37Rv (position 3119185..3123576, 4392bp) 410289007700 putative transposase OrfB; Reviewed; Region: PHA02517 410289007701 HTH-like domain; Region: HTH_21; pfam13276 410289007702 Integrase core domain; Region: rve; pfam00665 410289007703 Integrase core domain; Region: rve_3; pfam13683 410289007704 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 410289007705 Transposase; Region: HTH_Tnp_1; cl17663 410289007706 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 410289007707 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 410289007708 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 410289007709 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cd09662 410289007710 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cd09663 410289007711 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 410289007712 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 410289007713 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 410289007714 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 410289007715 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 410289007716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 410289007717 Uncharacterized conserved protein [Function unknown]; Region: COG2253 410289007718 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 410289007719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 410289007720 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 410289007721 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 410289007722 putative active site [active] 410289007723 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 410289007724 enoyl-CoA hydratase; Provisional; Region: PRK06190 410289007725 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289007726 substrate binding site [chemical binding]; other site 410289007727 oxyanion hole (OAH) forming residues; other site 410289007728 trimer interface [polypeptide binding]; other site 410289007729 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 410289007730 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 410289007731 Walker A/P-loop; other site 410289007732 ATP binding site [chemical binding]; other site 410289007733 Q-loop/lid; other site 410289007734 ABC transporter signature motif; other site 410289007735 Walker B; other site 410289007736 D-loop; other site 410289007737 H-loop/switch region; other site 410289007738 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 410289007739 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 410289007740 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 410289007741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289007742 dimer interface [polypeptide binding]; other site 410289007743 conserved gate region; other site 410289007744 putative PBP binding loops; other site 410289007745 ABC-ATPase subunit interface; other site 410289007746 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 410289007747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289007748 dimer interface [polypeptide binding]; other site 410289007749 conserved gate region; other site 410289007750 putative PBP binding loops; other site 410289007751 ABC-ATPase subunit interface; other site 410289007752 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 410289007753 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 410289007754 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 410289007755 DHH family; Region: DHH; pfam01368 410289007756 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 410289007757 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 410289007758 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 410289007759 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 410289007760 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 410289007761 G1 box; other site 410289007762 putative GEF interaction site [polypeptide binding]; other site 410289007763 GTP/Mg2+ binding site [chemical binding]; other site 410289007764 Switch I region; other site 410289007765 G2 box; other site 410289007766 G3 box; other site 410289007767 Switch II region; other site 410289007768 G4 box; other site 410289007769 G5 box; other site 410289007770 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 410289007771 Translation-initiation factor 2; Region: IF-2; pfam11987 410289007772 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 410289007773 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 410289007774 putative RNA binding cleft [nucleotide binding]; other site 410289007775 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 410289007776 NusA N-terminal domain; Region: NusA_N; pfam08529 410289007777 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 410289007778 RNA binding site [nucleotide binding]; other site 410289007779 homodimer interface [polypeptide binding]; other site 410289007780 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 410289007781 G-X-X-G motif; other site 410289007782 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 410289007783 G-X-X-G motif; other site 410289007784 ribosome maturation protein RimP; Reviewed; Region: PRK00092 410289007785 Sm and related proteins; Region: Sm_like; cl00259 410289007786 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 410289007787 putative oligomer interface [polypeptide binding]; other site 410289007788 putative RNA binding site [nucleotide binding]; other site 410289007789 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 410289007790 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 410289007791 dinuclear metal binding motif [ion binding]; other site 410289007792 prolyl-tRNA synthetase; Provisional; Region: PRK09194 410289007793 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 410289007794 dimer interface [polypeptide binding]; other site 410289007795 motif 1; other site 410289007796 active site 410289007797 motif 2; other site 410289007798 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 410289007799 putative deacylase active site [active] 410289007800 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 410289007801 active site 410289007802 motif 3; other site 410289007803 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 410289007804 anticodon binding site; other site 410289007805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289007806 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 410289007807 putative substrate translocation pore; other site 410289007808 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 410289007809 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 410289007810 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 410289007811 homodimer interface [polypeptide binding]; other site 410289007812 active site 410289007813 SAM binding site [chemical binding]; other site 410289007814 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 410289007815 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 410289007816 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 410289007817 catalytic triad [active] 410289007818 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 410289007819 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 410289007820 homodimer interface [polypeptide binding]; other site 410289007821 Walker A motif; other site 410289007822 ATP binding site [chemical binding]; other site 410289007823 hydroxycobalamin binding site [chemical binding]; other site 410289007824 Walker B motif; other site 410289007825 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 410289007826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289007827 Walker A motif; other site 410289007828 ATP binding site [chemical binding]; other site 410289007829 Walker B motif; other site 410289007830 arginine finger; other site 410289007831 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 410289007832 metal ion-dependent adhesion site (MIDAS); other site 410289007833 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 410289007834 malate:quinone oxidoreductase; Validated; Region: PRK05257 410289007835 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 410289007836 PE family; Region: PE; pfam00934 410289007837 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 410289007838 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 410289007839 mycothione reductase; Reviewed; Region: PRK07846 410289007840 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 410289007841 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 410289007842 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 410289007843 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 410289007844 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 410289007845 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 410289007846 short chain dehydrogenase; Provisional; Region: PRK06057 410289007847 classical (c) SDRs; Region: SDR_c; cd05233 410289007848 NAD(P) binding site [chemical binding]; other site 410289007849 active site 410289007850 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 410289007851 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 410289007852 NAD(P) binding site [chemical binding]; other site 410289007853 catalytic residues [active] 410289007854 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 410289007855 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 410289007856 catalytic triad [active] 410289007857 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 410289007858 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 410289007859 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 410289007860 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 410289007861 active site 410289007862 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 410289007863 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 410289007864 putative active site [active] 410289007865 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 410289007866 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 410289007867 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 410289007868 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 410289007869 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 410289007870 Predicted acetyltransferase [General function prediction only]; Region: COG3393 410289007871 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 410289007872 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 410289007873 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 410289007874 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 410289007875 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 410289007876 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 410289007877 active site 410289007878 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 410289007879 protein binding site [polypeptide binding]; other site 410289007880 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 410289007881 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 410289007882 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 410289007883 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 410289007884 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 410289007885 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 410289007886 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 410289007887 Fasciclin domain; Region: Fasciclin; pfam02469 410289007888 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 410289007889 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 410289007890 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 410289007891 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 410289007892 catalytic residues [active] 410289007893 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 410289007894 Fasciclin domain; Region: Fasciclin; pfam02469 410289007895 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 410289007896 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 410289007897 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 410289007898 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 410289007899 catalytic residues [active] 410289007900 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 410289007901 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 410289007902 FeS/SAM binding site; other site 410289007903 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 410289007904 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 410289007905 ribosome recycling factor; Reviewed; Region: frr; PRK00083 410289007906 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 410289007907 hinge region; other site 410289007908 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 410289007909 putative nucleotide binding site [chemical binding]; other site 410289007910 uridine monophosphate binding site [chemical binding]; other site 410289007911 homohexameric interface [polypeptide binding]; other site 410289007912 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 410289007913 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 410289007914 DNA binding site [nucleotide binding] 410289007915 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 410289007916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 410289007917 Probable transposase; Region: OrfB_IS605; pfam01385 410289007918 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 410289007919 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 410289007920 catalytic residues [active] 410289007921 catalytic nucleophile [active] 410289007922 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 410289007923 MarR family; Region: MarR; pfam01047 410289007924 amidase; Provisional; Region: PRK07869 410289007925 Amidase; Region: Amidase; pfam01425 410289007926 elongation factor Ts; Provisional; Region: tsf; PRK09377 410289007927 UBA/TS-N domain; Region: UBA; pfam00627 410289007928 Elongation factor TS; Region: EF_TS; pfam00889 410289007929 Elongation factor TS; Region: EF_TS; pfam00889 410289007930 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 410289007931 rRNA interaction site [nucleotide binding]; other site 410289007932 S8 interaction site; other site 410289007933 putative laminin-1 binding site; other site 410289007934 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 410289007935 Peptidase family M23; Region: Peptidase_M23; pfam01551 410289007936 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289007937 PPE family; Region: PPE; pfam00823 410289007938 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 410289007939 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 410289007940 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 410289007941 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 410289007942 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 410289007943 active site 410289007944 DNA binding site [nucleotide binding] 410289007945 Int/Topo IB signature motif; other site 410289007946 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 410289007947 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 410289007948 FAD binding pocket [chemical binding]; other site 410289007949 FAD binding motif [chemical binding]; other site 410289007950 phosphate binding motif [ion binding]; other site 410289007951 NAD binding pocket [chemical binding]; other site 410289007952 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 410289007953 DNA protecting protein DprA; Region: dprA; TIGR00732 410289007954 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 410289007955 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 410289007956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289007957 Walker A motif; other site 410289007958 ATP binding site [chemical binding]; other site 410289007959 Walker B motif; other site 410289007960 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 410289007961 hypothetical protein; Reviewed; Region: PRK12497 410289007962 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 410289007963 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 410289007964 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 410289007965 putative molybdopterin cofactor binding site [chemical binding]; other site 410289007966 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 410289007967 putative molybdopterin cofactor binding site; other site 410289007968 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 410289007969 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 410289007970 RNA/DNA hybrid binding site [nucleotide binding]; other site 410289007971 active site 410289007972 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 410289007973 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 410289007974 Catalytic site [active] 410289007975 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 410289007976 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 410289007977 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 410289007978 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 410289007979 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 410289007980 RimM N-terminal domain; Region: RimM; pfam01782 410289007981 hypothetical protein; Provisional; Region: PRK02821 410289007982 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 410289007983 G-X-X-G motif; other site 410289007984 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 410289007985 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 410289007986 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 410289007987 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 410289007988 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289007989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289007990 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 410289007991 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 410289007992 active site 410289007993 putative substrate binding pocket [chemical binding]; other site 410289007994 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 410289007995 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 410289007996 Catalytic domain of Protein Kinases; Region: PKc; cd00180 410289007997 active site 410289007998 ATP binding site [chemical binding]; other site 410289007999 substrate binding site [chemical binding]; other site 410289008000 activation loop (A-loop); other site 410289008001 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 410289008002 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 410289008003 active site 410289008004 signal recognition particle protein; Provisional; Region: PRK10867 410289008005 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 410289008006 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 410289008007 P loop; other site 410289008008 GTP binding site [chemical binding]; other site 410289008009 Signal peptide binding domain; Region: SRP_SPB; pfam02978 410289008010 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 410289008011 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 410289008012 ATP binding site [chemical binding]; other site 410289008013 putative Mg++ binding site [ion binding]; other site 410289008014 PII uridylyl-transferase; Provisional; Region: PRK03381 410289008015 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 410289008016 metal binding triad; other site 410289008017 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 410289008018 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 410289008019 Zn2+ binding site [ion binding]; other site 410289008020 Mg2+ binding site [ion binding]; other site 410289008021 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 410289008022 Nitrogen regulatory protein P-II; Region: P-II; smart00938 410289008023 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 410289008024 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 410289008025 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 410289008026 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 410289008027 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 410289008028 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 410289008029 Walker A/P-loop; other site 410289008030 ATP binding site [chemical binding]; other site 410289008031 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 410289008032 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 410289008033 ABC transporter signature motif; other site 410289008034 Walker B; other site 410289008035 D-loop; other site 410289008036 H-loop/switch region; other site 410289008037 acylphosphatase; Provisional; Region: PRK14422 410289008038 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 410289008039 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 410289008040 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 410289008041 DNA binding site [nucleotide binding] 410289008042 catalytic residue [active] 410289008043 H2TH interface [polypeptide binding]; other site 410289008044 putative catalytic residues [active] 410289008045 turnover-facilitating residue; other site 410289008046 intercalation triad [nucleotide binding]; other site 410289008047 8OG recognition residue [nucleotide binding]; other site 410289008048 putative reading head residues; other site 410289008049 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 410289008050 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 410289008051 ribonuclease III; Reviewed; Region: rnc; PRK00102 410289008052 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 410289008053 dimerization interface [polypeptide binding]; other site 410289008054 active site 410289008055 metal binding site [ion binding]; metal-binding site 410289008056 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 410289008057 dsRNA binding site [nucleotide binding]; other site 410289008058 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 410289008059 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 410289008060 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 410289008061 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 410289008062 acyl-CoA synthetase; Validated; Region: PRK05850 410289008063 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 410289008064 acyl-activating enzyme (AAE) consensus motif; other site 410289008065 active site 410289008066 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 410289008067 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 410289008068 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289008069 active site 410289008070 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 410289008071 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 410289008072 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 410289008073 NADP binding site [chemical binding]; other site 410289008074 KR domain; Region: KR; pfam08659 410289008075 active site 410289008076 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289008077 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289008078 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 410289008079 active site 410289008080 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 410289008081 Acyl transferase domain; Region: Acyl_transf_1; cl08282 410289008082 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 410289008083 KR domain; Region: KR; pfam08659 410289008084 NADP binding site [chemical binding]; other site 410289008085 active site 410289008086 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289008087 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 410289008088 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289008089 active site 410289008090 Acyl transferase domain; Region: Acyl_transf_1; cl08282 410289008091 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 410289008092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289008093 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 410289008094 Enoylreductase; Region: PKS_ER; smart00829 410289008095 NAD(P) binding site [chemical binding]; other site 410289008096 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 410289008097 KR domain; Region: KR; pfam08659 410289008098 putative NADP binding site [chemical binding]; other site 410289008099 active site 410289008100 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289008101 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 410289008102 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289008103 active site 410289008104 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 410289008105 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 410289008106 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 410289008107 KR domain; Region: KR; pfam08659 410289008108 putative NADP binding site [chemical binding]; other site 410289008109 active site 410289008110 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289008111 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 410289008112 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289008113 active site 410289008114 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 410289008115 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 410289008116 Condensation domain; Region: Condensation; pfam00668 410289008117 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 410289008118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289008119 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 410289008120 Walker A/P-loop; other site 410289008121 ATP binding site [chemical binding]; other site 410289008122 Q-loop/lid; other site 410289008123 ABC transporter signature motif; other site 410289008124 Walker B; other site 410289008125 D-loop; other site 410289008126 H-loop/switch region; other site 410289008127 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 410289008128 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 410289008129 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 410289008130 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 410289008131 acyltransferase PapA5; Provisional; Region: PRK09294 410289008132 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 410289008133 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289008134 active site 410289008135 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 410289008136 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 410289008137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289008138 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 410289008139 Enoylreductase; Region: PKS_ER; smart00829 410289008140 NAD(P) binding site [chemical binding]; other site 410289008141 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 410289008142 KR domain; Region: KR; pfam08659 410289008143 putative NADP binding site [chemical binding]; other site 410289008144 active site 410289008145 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289008146 acyl-CoA synthetase; Validated; Region: PRK05850 410289008147 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 410289008148 acyl-activating enzyme (AAE) consensus motif; other site 410289008149 active site 410289008150 MMPL family; Region: MMPL; pfam03176 410289008151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 410289008152 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 410289008153 Integrase core domain; Region: rve; pfam00665 410289008154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 410289008155 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 410289008156 Erythronolide synthase docking; Region: Docking; pfam08990 410289008157 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 410289008158 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289008159 active site 410289008160 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 410289008161 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 410289008162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289008163 Enoylreductase; Region: PKS_ER; smart00829 410289008164 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 410289008165 NAD(P) binding site [chemical binding]; other site 410289008166 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 410289008167 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 410289008168 putative NADP binding site [chemical binding]; other site 410289008169 active site 410289008170 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289008171 acyl-CoA synthetase; Validated; Region: PRK06060 410289008172 Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; Region: BCL_like; cd05919 410289008173 dimer interface [polypeptide binding]; other site 410289008174 acyl-activating enzyme (AAE) consensus motif; other site 410289008175 putative active site [active] 410289008176 putative AMP binding site [chemical binding]; other site 410289008177 putative CoA binding site [chemical binding]; other site 410289008178 chemical substrate binding site [chemical binding]; other site 410289008179 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289008180 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 410289008181 acyl-CoA synthetase; Validated; Region: PRK05850 410289008182 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 410289008183 acyl-activating enzyme (AAE) consensus motif; other site 410289008184 active site 410289008185 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 410289008186 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 410289008187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289008188 S-adenosylmethionine binding site [chemical binding]; other site 410289008189 Uncharacterized conserved protein [Function unknown]; Region: COG3268 410289008190 Methyltransferase domain; Region: Methyltransf_23; pfam13489 410289008191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289008192 S-adenosylmethionine binding site [chemical binding]; other site 410289008193 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 410289008194 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 410289008195 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 410289008196 metal-binding site 410289008197 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 410289008198 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 410289008199 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 410289008200 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 410289008201 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 410289008202 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 410289008203 active site 410289008204 TDP-binding site; other site 410289008205 acceptor substrate-binding pocket; other site 410289008206 Predicted permease; Region: DUF318; pfam03773 410289008207 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 410289008208 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 410289008209 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 410289008210 putative active site [active] 410289008211 putative substrate binding site [chemical binding]; other site 410289008212 putative cosubstrate binding site; other site 410289008213 catalytic site [active] 410289008214 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 410289008215 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 410289008216 active site 410289008217 (T/H)XGH motif; other site 410289008218 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 410289008219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289008220 S-adenosylmethionine binding site [chemical binding]; other site 410289008221 pyruvate carboxylase; Reviewed; Region: PRK12999 410289008222 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 410289008223 ATP-grasp domain; Region: ATP-grasp_4; cl17255 410289008224 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 410289008225 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 410289008226 active site 410289008227 catalytic residues [active] 410289008228 metal binding site [ion binding]; metal-binding site 410289008229 homodimer binding site [polypeptide binding]; other site 410289008230 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 410289008231 carboxyltransferase (CT) interaction site; other site 410289008232 biotinylation site [posttranslational modification]; other site 410289008233 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 410289008234 putative active site [active] 410289008235 redox center [active] 410289008236 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 410289008237 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 410289008238 catalytic residues [active] 410289008239 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 410289008240 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 410289008241 substrate binding pocket [chemical binding]; other site 410289008242 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 410289008243 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 410289008244 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 410289008245 active site 410289008246 catalytic tetrad [active] 410289008247 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 410289008248 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 410289008249 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 410289008250 generic binding surface II; other site 410289008251 ssDNA binding site; other site 410289008252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 410289008253 ATP binding site [chemical binding]; other site 410289008254 putative Mg++ binding site [ion binding]; other site 410289008255 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 410289008256 nucleotide binding region [chemical binding]; other site 410289008257 ATP-binding site [chemical binding]; other site 410289008258 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 410289008259 DAK2 domain; Region: Dak2; cl03685 410289008260 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 410289008261 ligand binding site [chemical binding]; other site 410289008262 active site 410289008263 UGI interface [polypeptide binding]; other site 410289008264 catalytic site [active] 410289008265 thiamine monophosphate kinase; Provisional; Region: PRK05731 410289008266 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 410289008267 ATP binding site [chemical binding]; other site 410289008268 dimerization interface [polypeptide binding]; other site 410289008269 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 410289008270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 410289008271 Probable transposase; Region: OrfB_IS605; pfam01385 410289008272 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 410289008273 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 410289008274 catalytic residues [active] 410289008275 catalytic nucleophile [active] 410289008276 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 410289008277 I-RD07, 354 bp. Region of Difference I-RD07, inserted region of 354bp (position 3290865..3291218, 354bp), in Mycobacterium bovis BCG Pasteur, compared to Mycobacterium tuberculosis H37Rv2 (position: 3336704..3336705) and of 472bp (position 3290806..3291277, 472bp) compared to Mycobacterium bovis AF2122/97 (position 3293332..3293333). Intergenic region 410289008278 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 410289008279 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 410289008280 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 410289008281 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 410289008282 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 410289008283 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 410289008284 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 410289008285 polyphosphate kinase; Provisional; Region: PRK05443 410289008286 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 410289008287 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 410289008288 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 410289008289 putative domain interface [polypeptide binding]; other site 410289008290 putative active site [active] 410289008291 catalytic site [active] 410289008292 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 410289008293 putative domain interface [polypeptide binding]; other site 410289008294 putative active site [active] 410289008295 catalytic site [active] 410289008296 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 410289008297 active site 410289008298 Ap6A binding site [chemical binding]; other site 410289008299 nudix motif; other site 410289008300 metal binding site [ion binding]; metal-binding site 410289008301 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 410289008302 catalytic core [active] 410289008303 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 410289008304 IHF - DNA interface [nucleotide binding]; other site 410289008305 IHF dimer interface [polypeptide binding]; other site 410289008306 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 410289008307 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 410289008308 substrate binding site [chemical binding]; other site 410289008309 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 410289008310 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 410289008311 substrate binding site [chemical binding]; other site 410289008312 ligand binding site [chemical binding]; other site 410289008313 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 410289008314 Transcriptional regulator [Transcription]; Region: IclR; COG1414 410289008315 Bacterial transcriptional regulator; Region: IclR; pfam01614 410289008316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289008317 S-adenosylmethionine binding site [chemical binding]; other site 410289008318 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 410289008319 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 410289008320 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 410289008321 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 410289008322 active site 410289008323 HIGH motif; other site 410289008324 nucleotide binding site [chemical binding]; other site 410289008325 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 410289008326 active site 410289008327 KMSKS motif; other site 410289008328 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 410289008329 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 410289008330 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 410289008331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289008332 Major Facilitator Superfamily; Region: MFS_1; pfam07690 410289008333 putative substrate translocation pore; other site 410289008334 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 410289008335 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 410289008336 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 410289008337 ligand binding site [chemical binding]; other site 410289008338 NAD binding site [chemical binding]; other site 410289008339 dimerization interface [polypeptide binding]; other site 410289008340 catalytic site [active] 410289008341 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 410289008342 putative L-serine binding site [chemical binding]; other site 410289008343 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 410289008344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 410289008345 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 410289008346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 410289008347 phosphorylation site [posttranslational modification] 410289008348 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 410289008349 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 410289008350 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 410289008351 ketol-acid reductoisomerase; Provisional; Region: PRK05479 410289008352 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 410289008353 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 410289008354 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 410289008355 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 410289008356 putative valine binding site [chemical binding]; other site 410289008357 dimer interface [polypeptide binding]; other site 410289008358 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 410289008359 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 410289008360 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 410289008361 PYR/PP interface [polypeptide binding]; other site 410289008362 dimer interface [polypeptide binding]; other site 410289008363 TPP binding site [chemical binding]; other site 410289008364 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 410289008365 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 410289008366 TPP-binding site [chemical binding]; other site 410289008367 dimer interface [polypeptide binding]; other site 410289008368 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 410289008369 Predicted membrane protein [Function unknown]; Region: COG2259 410289008370 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 410289008371 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 410289008372 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 410289008373 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 410289008374 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 410289008375 GatB domain; Region: GatB_Yqey; smart00845 410289008376 6-phosphofructokinase; Provisional; Region: PRK03202 410289008377 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 410289008378 active site 410289008379 ADP/pyrophosphate binding site [chemical binding]; other site 410289008380 dimerization interface [polypeptide binding]; other site 410289008381 allosteric effector site; other site 410289008382 fructose-1,6-bisphosphate binding site; other site 410289008383 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 410289008384 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 410289008385 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 410289008386 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 410289008387 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 410289008388 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 410289008389 nucleotide binding pocket [chemical binding]; other site 410289008390 K-X-D-G motif; other site 410289008391 catalytic site [active] 410289008392 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 410289008393 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 410289008394 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 410289008395 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 410289008396 Dimer interface [polypeptide binding]; other site 410289008397 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 410289008398 PknH-like extracellular domain; Region: PknH_C; pfam14032 410289008399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 410289008400 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289008401 PPE family; Region: PPE; pfam00823 410289008402 similar to PE family protein 410289008403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 410289008404 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289008405 PPE family; Region: PPE; pfam00823 410289008406 Transposase, Mutator family; Region: Transposase_mut; pfam00872 410289008407 MULE transposase domain; Region: MULE; pfam10551 410289008408 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 410289008409 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 410289008410 Ligand Binding Site [chemical binding]; other site 410289008411 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 410289008412 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 410289008413 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 410289008414 catalytic residue [active] 410289008415 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 410289008416 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 410289008417 putative acyl-acceptor binding pocket; other site 410289008418 Putative hemolysin [General function prediction only]; Region: COG3176 410289008419 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 410289008420 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 410289008421 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 410289008422 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 410289008423 Ligand binding site [chemical binding]; other site 410289008424 Electron transfer flavoprotein domain; Region: ETF; pfam01012 410289008425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289008426 S-adenosylmethionine binding site [chemical binding]; other site 410289008427 Uncharacterized conserved protein [Function unknown]; Region: COG1543 410289008428 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 410289008429 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 410289008430 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 410289008431 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 410289008432 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 410289008433 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 410289008434 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 410289008435 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 410289008436 trimer interface [polypeptide binding]; other site 410289008437 active site 410289008438 substrate binding site [chemical binding]; other site 410289008439 CoA binding site [chemical binding]; other site 410289008440 FOG: WD40-like repeat [Function unknown]; Region: COG1520 410289008441 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 410289008442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289008443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289008444 S-adenosylmethionine binding site [chemical binding]; other site 410289008445 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289008446 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 410289008447 substrate binding site [chemical binding]; other site 410289008448 oxyanion hole (OAH) forming residues; other site 410289008449 trimer interface [polypeptide binding]; other site 410289008450 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 410289008451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289008452 Walker A/P-loop; other site 410289008453 ATP binding site [chemical binding]; other site 410289008454 Q-loop/lid; other site 410289008455 ABC transporter signature motif; other site 410289008456 Walker B; other site 410289008457 D-loop; other site 410289008458 H-loop/switch region; other site 410289008459 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 410289008460 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 410289008461 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 410289008462 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 410289008463 motif II; other site 410289008464 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 410289008465 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 410289008466 D-pathway; other site 410289008467 Putative ubiquinol binding site [chemical binding]; other site 410289008468 Low-spin heme (heme b) binding site [chemical binding]; other site 410289008469 Putative water exit pathway; other site 410289008470 Binuclear center (heme o3/CuB) [ion binding]; other site 410289008471 K-pathway; other site 410289008472 Putative proton exit pathway; other site 410289008473 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 410289008474 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 410289008475 siderophore binding site; other site 410289008476 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 410289008477 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 410289008478 putative NAD(P) binding site [chemical binding]; other site 410289008479 putative substrate binding site [chemical binding]; other site 410289008480 catalytic Zn binding site [ion binding]; other site 410289008481 structural Zn binding site [ion binding]; other site 410289008482 dimer interface [polypeptide binding]; other site 410289008483 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 410289008484 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 410289008485 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 410289008486 dimer interface [polypeptide binding]; other site 410289008487 putative radical transfer pathway; other site 410289008488 diiron center [ion binding]; other site 410289008489 tyrosyl radical; other site 410289008490 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 410289008491 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 410289008492 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289008493 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289008494 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 410289008495 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 410289008496 Class I ribonucleotide reductase; Region: RNR_I; cd01679 410289008497 active site 410289008498 dimer interface [polypeptide binding]; other site 410289008499 catalytic residues [active] 410289008500 effector binding site; other site 410289008501 R2 peptide binding site; other site 410289008502 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 410289008503 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 410289008504 catalytic residues [active] 410289008505 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 410289008506 Predicted flavoprotein [General function prediction only]; Region: COG0431 410289008507 DNA polymerase IV; Validated; Region: PRK03352 410289008508 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 410289008509 active site 410289008510 DNA binding site [nucleotide binding] 410289008511 short chain dehydrogenase; Provisional; Region: PRK07832 410289008512 classical (c) SDRs; Region: SDR_c; cd05233 410289008513 NAD(P) binding site [chemical binding]; other site 410289008514 active site 410289008515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289008516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289008517 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289008518 Cytochrome P450; Region: p450; cl12078 410289008519 Transcriptional regulators [Transcription]; Region: FadR; COG2186 410289008520 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 410289008521 DNA-binding site [nucleotide binding]; DNA binding site 410289008522 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 410289008523 Transcriptional regulators [Transcription]; Region: FadR; COG2186 410289008524 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 410289008525 DNA-binding site [nucleotide binding]; DNA binding site 410289008526 FCD domain; Region: FCD; pfam07729 410289008527 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289008528 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 410289008529 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289008530 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289008531 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289008532 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289008533 active site 410289008534 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 410289008535 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 410289008536 active site 410289008537 DNA binding site [nucleotide binding] 410289008538 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 410289008539 DNA binding site [nucleotide binding] 410289008540 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 410289008541 Carbon starvation protein CstA; Region: CstA; pfam02554 410289008542 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 410289008543 Predicted membrane protein [Function unknown]; Region: COG2259 410289008544 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 410289008545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 410289008546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289008547 Protein of unknown function (DUF732); Region: DUF732; pfam05305 410289008548 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 410289008549 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 410289008550 active site 410289008551 substrate binding site [chemical binding]; other site 410289008552 metal binding site [ion binding]; metal-binding site 410289008553 camphor resistance protein CrcB; Provisional; Region: PRK14216 410289008554 camphor resistance protein CrcB; Provisional; Region: PRK14228 410289008555 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 410289008556 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 410289008557 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 410289008558 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 410289008559 Uncharacterized conserved protein [Function unknown]; Region: COG3189 410289008560 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289008561 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289008562 active site 410289008563 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 410289008564 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 410289008565 putative hydrophobic ligand binding site [chemical binding]; other site 410289008566 protein interface [polypeptide binding]; other site 410289008567 gate; other site 410289008568 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 410289008569 Sulfatase; Region: Sulfatase; pfam00884 410289008570 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 410289008571 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 410289008572 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 410289008573 Catalytic domain of Protein Kinases; Region: PKc; cd00180 410289008574 active site 410289008575 ATP binding site [chemical binding]; other site 410289008576 substrate binding site [chemical binding]; other site 410289008577 activation loop (A-loop); other site 410289008578 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 410289008579 AAA ATPase domain; Region: AAA_16; pfam13191 410289008580 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 410289008581 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 410289008582 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 410289008583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 410289008584 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 410289008585 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 410289008586 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 410289008587 short chain dehydrogenase; Provisional; Region: PRK07832 410289008588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289008589 NAD(P) binding site [chemical binding]; other site 410289008590 active site 410289008591 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 410289008592 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 410289008593 NAD binding site [chemical binding]; other site 410289008594 catalytic Zn binding site [ion binding]; other site 410289008595 substrate binding site [chemical binding]; other site 410289008596 structural Zn binding site [ion binding]; other site 410289008597 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 410289008598 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 410289008599 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 410289008600 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 410289008601 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 410289008602 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 410289008603 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289008604 acyl-activating enzyme (AAE) consensus motif; other site 410289008605 AMP binding site [chemical binding]; other site 410289008606 active site 410289008607 CoA binding site [chemical binding]; other site 410289008608 SPFH domain / Band 7 family; Region: Band_7; pfam01145 410289008609 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 410289008610 Patatin-like phospholipase; Region: Patatin; pfam01734 410289008611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 410289008612 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 410289008613 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 410289008614 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289008615 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289008616 active site 410289008617 Predicted transcriptional regulators [Transcription]; Region: COG1733 410289008618 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 410289008619 dimerization interface [polypeptide binding]; other site 410289008620 putative DNA binding site [nucleotide binding]; other site 410289008621 putative Zn2+ binding site [ion binding]; other site 410289008622 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 410289008623 PE family; Region: PE; pfam00934 410289008624 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 410289008625 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 410289008626 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 410289008627 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 410289008628 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 410289008629 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 410289008630 SmpB-tmRNA interface; other site 410289008631 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 410289008632 FtsX-like permease family; Region: FtsX; pfam02687 410289008633 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 410289008634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 410289008635 Walker A/P-loop; other site 410289008636 ATP binding site [chemical binding]; other site 410289008637 Q-loop/lid; other site 410289008638 ABC transporter signature motif; other site 410289008639 Walker B; other site 410289008640 D-loop; other site 410289008641 H-loop/switch region; other site 410289008642 Mechanosensitive ion channel; Region: MS_channel; pfam00924 410289008643 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 410289008644 peptide chain release factor 2; Validated; Region: prfB; PRK00578 410289008645 This domain is found in peptide chain release factors; Region: PCRF; smart00937 410289008646 RF-1 domain; Region: RF-1; pfam00472 410289008647 ferredoxin-NADP+ reductase; Region: PLN02852 410289008648 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 410289008649 FAD binding domain; Region: FAD_binding_4; pfam01565 410289008650 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 410289008651 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 410289008652 FeS/SAM binding site; other site 410289008653 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 410289008654 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 410289008655 aromatic arch; other site 410289008656 DCoH dimer interaction site [polypeptide binding]; other site 410289008657 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 410289008658 DCoH tetramer interaction site [polypeptide binding]; other site 410289008659 substrate binding site [chemical binding]; other site 410289008660 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 410289008661 trimer interface [polypeptide binding]; other site 410289008662 dimer interface [polypeptide binding]; other site 410289008663 putative active site [active] 410289008664 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 410289008665 MoaE interaction surface [polypeptide binding]; other site 410289008666 MoeB interaction surface [polypeptide binding]; other site 410289008667 thiocarboxylated glycine; other site 410289008668 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 410289008669 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 410289008670 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 410289008671 nucleoside/Zn binding site; other site 410289008672 dimer interface [polypeptide binding]; other site 410289008673 catalytic motif [active] 410289008674 Transposase, Mutator family; Region: Transposase_mut; pfam00872 410289008675 MULE transposase domain; Region: MULE; pfam10551 410289008676 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 410289008677 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 410289008678 ATP binding site [chemical binding]; other site 410289008679 substrate interface [chemical binding]; other site 410289008680 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 410289008681 active site residue [active] 410289008682 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 410289008683 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 410289008684 active site residue [active] 410289008685 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 410289008686 active site residue [active] 410289008687 RD12, 2775 bp. Region of Difference RD12, deleted region in Mycobacterium bovis BCG Pasteur (position 3439226..3439227) and Mycobacterium bovis AF2122/97 (position 3441287..3441288) compared to Mycobacterium tuberculosis H37Rv2 (position: 3484741..3487515) . Removes genes Rv3118-Rv3120 and merges truncated genes Rv3117 and Rv3121 410289008688 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 410289008689 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 410289008690 DNA binding site [nucleotide binding] 410289008691 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289008692 PPE family; Region: PPE; pfam00823 410289008693 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 410289008694 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 410289008695 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 410289008696 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 410289008697 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 410289008698 dimer interface [polypeptide binding]; other site 410289008699 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 410289008700 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 410289008701 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 410289008702 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 410289008703 Histidine kinase; Region: HisKA_3; pfam07730 410289008704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 410289008705 ATP binding site [chemical binding]; other site 410289008706 Mg2+ binding site [ion binding]; other site 410289008707 G-X-G motif; other site 410289008708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 410289008709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 410289008710 active site 410289008711 phosphorylation site [posttranslational modification] 410289008712 intermolecular recognition site; other site 410289008713 dimerization interface [polypeptide binding]; other site 410289008714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 410289008715 DNA binding residues [nucleotide binding] 410289008716 dimerization interface [polypeptide binding]; other site 410289008717 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 410289008718 Ligand Binding Site [chemical binding]; other site 410289008719 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289008720 PPE family; Region: PPE; pfam00823 410289008721 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 410289008722 I-RD08, 1337 bp. Region of Difference I-RD08, inserted region in Mycobacterium bovis BCG Pasteur (position 3453376..3454712, 1337bp) and Mycobacterium bovis AF2122/97 (position 3455438..3456774, 1337bp) compared to Mycobacterium tuberculosis H37Rv2 (position: 3501665..3501666). Leads to a longer PPE50 gene 410289008723 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289008724 PPE family; Region: PPE; pfam00823 410289008725 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 410289008726 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 410289008727 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 410289008728 active site 410289008729 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 410289008730 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 410289008731 FeS/SAM binding site; other site 410289008732 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289008733 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289008734 active site 410289008735 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289008736 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289008737 active site 410289008738 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 410289008739 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 410289008740 NAD(P) binding site [chemical binding]; other site 410289008741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 410289008742 active site 410289008743 phosphorylation site [posttranslational modification] 410289008744 intermolecular recognition site; other site 410289008745 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289008746 PPE family; Region: PPE; pfam00823 410289008747 NADH dehydrogenase subunit A; Validated; Region: PRK07928 410289008748 NADH dehydrogenase subunit B; Validated; Region: PRK06411 410289008749 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 410289008750 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 410289008751 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 410289008752 NADH dehydrogenase subunit D; Validated; Region: PRK06075 410289008753 NADH dehydrogenase subunit E; Validated; Region: PRK07539 410289008754 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 410289008755 putative dimer interface [polypeptide binding]; other site 410289008756 [2Fe-2S] cluster binding site [ion binding]; other site 410289008757 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 410289008758 SLBB domain; Region: SLBB; pfam10531 410289008759 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 410289008760 NADH dehydrogenase subunit G; Validated; Region: PRK07860 410289008761 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 410289008762 catalytic loop [active] 410289008763 iron binding site [ion binding]; other site 410289008764 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 410289008765 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 410289008766 [4Fe-4S] binding site [ion binding]; other site 410289008767 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 410289008768 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 410289008769 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 410289008770 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 410289008771 4Fe-4S binding domain; Region: Fer4; pfam00037 410289008772 4Fe-4S binding domain; Region: Fer4; pfam00037 410289008773 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 410289008774 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 410289008775 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 410289008776 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 410289008777 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 410289008778 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 410289008779 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 410289008780 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 410289008781 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 410289008782 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289008783 PPE family; Region: PPE; pfam00823 410289008784 I-RD09, 2146 bp. Region of Difference I-RD09, inserted region in Mycobacterium bovis BCG Pasteur (position 3481722..3483867, 2146bp) and Mycobacterium bovis AF2122/97 (position 3483784..3485929, 2146bp) compared to Mycobacterium tuberculosis H37Rv2 (position: 3528674..3528675). Leads to an additional gene, PPE70 410289008785 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289008786 PPE family; Region: PPE; pfam00823 410289008787 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 410289008788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289008789 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 410289008790 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 410289008791 [2Fe-2S] cluster binding site [ion binding]; other site 410289008792 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 410289008793 putative alpha subunit interface [polypeptide binding]; other site 410289008794 putative active site [active] 410289008795 putative substrate binding site [chemical binding]; other site 410289008796 Fe binding site [ion binding]; other site 410289008797 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 410289008798 Protein of unknown function DUF58; Region: DUF58; pfam01882 410289008799 MoxR-like ATPases [General function prediction only]; Region: COG0714 410289008800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289008801 Walker A motif; other site 410289008802 ATP binding site [chemical binding]; other site 410289008803 Walker B motif; other site 410289008804 arginine finger; other site 410289008805 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 410289008806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289008807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289008808 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 410289008809 putative active site [active] 410289008810 putative substrate binding site [chemical binding]; other site 410289008811 ATP binding site [chemical binding]; other site 410289008812 Phosphotransferase enzyme family; Region: APH; pfam01636 410289008813 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 410289008814 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 410289008815 hydroxyglutarate oxidase; Provisional; Region: PRK11728 410289008816 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 410289008817 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 410289008818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289008819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289008820 short chain dehydrogenase; Validated; Region: PRK08264 410289008821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289008822 NAD(P) binding site [chemical binding]; other site 410289008823 active site 410289008824 amidase; Provisional; Region: PRK06170 410289008825 Amidase; Region: Amidase; pfam01425 410289008826 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 410289008827 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 410289008828 TAP-like protein; Region: Abhydrolase_4; pfam08386 410289008829 Domain of unknown function (DUF385); Region: DUF385; pfam04075 410289008830 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 410289008831 AAA domain; Region: AAA_14; pfam13173 410289008832 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 410289008833 putative active site [active] 410289008834 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 410289008835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 410289008836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 410289008837 non-specific DNA binding site [nucleotide binding]; other site 410289008838 salt bridge; other site 410289008839 sequence-specific DNA binding site [nucleotide binding]; other site 410289008840 RES domain; Region: RES; pfam08808 410289008841 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 410289008842 Helix-turn-helix domain; Region: HTH_38; pfam13936 410289008843 Integrase core domain; Region: rve; pfam00665 410289008844 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 410289008845 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 410289008846 hypothetical protein; Validated; Region: PRK00068 410289008847 Uncharacterized conserved protein [Function unknown]; Region: COG1615 410289008848 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 410289008849 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 410289008850 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 410289008851 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 410289008852 Uncharacterized conserved protein [Function unknown]; Region: COG5282 410289008853 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 410289008854 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 410289008855 ABC1 family; Region: ABC1; pfam03109 410289008856 Phosphotransferase enzyme family; Region: APH; pfam01636 410289008857 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 410289008858 active site 410289008859 ATP binding site [chemical binding]; other site 410289008860 Transcription factor WhiB; Region: Whib; pfam02467 410289008861 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 410289008862 Part of AAA domain; Region: AAA_19; pfam13245 410289008863 Family description; Region: UvrD_C_2; pfam13538 410289008864 HRDC domain; Region: HRDC; pfam00570 410289008865 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 410289008866 catalytic residues [active] 410289008867 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 410289008868 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 410289008869 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 410289008870 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 410289008871 putative NADH binding site [chemical binding]; other site 410289008872 putative active site [active] 410289008873 nudix motif; other site 410289008874 putative metal binding site [ion binding]; other site 410289008875 Ion channel; Region: Ion_trans_2; pfam07885 410289008876 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 410289008877 TrkA-N domain; Region: TrkA_N; pfam02254 410289008878 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 410289008879 Part of AAA domain; Region: AAA_19; pfam13245 410289008880 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 410289008881 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 410289008882 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 410289008883 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 410289008884 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 410289008885 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 410289008886 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 410289008887 active site 410289008888 DNA binding site [nucleotide binding] 410289008889 TIGR02569 family protein; Region: TIGR02569_actnb 410289008890 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 410289008891 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 410289008892 ATP binding site [chemical binding]; other site 410289008893 substrate interface [chemical binding]; other site 410289008894 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 410289008895 active site residue [active] 410289008896 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 410289008897 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289008898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289008899 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 410289008900 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 410289008901 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 410289008902 DEAD-like helicases superfamily; Region: DEXDc; smart00487 410289008903 ATP binding site [chemical binding]; other site 410289008904 Mg++ binding site [ion binding]; other site 410289008905 motif III; other site 410289008906 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 410289008907 nucleotide binding region [chemical binding]; other site 410289008908 ATP-binding site [chemical binding]; other site 410289008909 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 410289008910 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 410289008911 P-loop; other site 410289008912 Magnesium ion binding site [ion binding]; other site 410289008913 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 410289008914 Magnesium ion binding site [ion binding]; other site 410289008915 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 410289008916 catalytic core [active] 410289008917 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 410289008918 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 410289008919 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 410289008920 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 410289008921 Transcription factor WhiB; Region: Whib; pfam02467 410289008922 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 410289008923 PAS domain S-box; Region: sensory_box; TIGR00229 410289008924 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 410289008925 Histidine kinase; Region: HisKA_2; pfam07568 410289008926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 410289008927 ATP binding site [chemical binding]; other site 410289008928 Mg2+ binding site [ion binding]; other site 410289008929 G-X-G motif; other site 410289008930 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 410289008931 carboxyltransferase (CT) interaction site; other site 410289008932 biotinylation site [posttranslational modification]; other site 410289008933 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 410289008934 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 410289008935 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 410289008936 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 410289008937 DNA binding residues [nucleotide binding] 410289008938 short chain dehydrogenase; Provisional; Region: PRK08278 410289008939 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 410289008940 NAD(P) binding site [chemical binding]; other site 410289008941 homodimer interface [polypeptide binding]; other site 410289008942 active site 410289008943 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 410289008944 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 410289008945 putative deacylase active site [active] 410289008946 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 410289008947 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 410289008948 Coenzyme A binding pocket [chemical binding]; other site 410289008949 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 410289008950 Phosphotransferase enzyme family; Region: APH; pfam01636 410289008951 putative active site [active] 410289008952 putative substrate binding site [chemical binding]; other site 410289008953 ATP binding site [chemical binding]; other site 410289008954 Uncharacterized conserved protein [Function unknown]; Region: COG2135 410289008955 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 410289008956 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 410289008957 hinge; other site 410289008958 active site 410289008959 Predicted GTPases [General function prediction only]; Region: COG1162 410289008960 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 410289008961 GTPase/Zn-binding domain interface [polypeptide binding]; other site 410289008962 GTP/Mg2+ binding site [chemical binding]; other site 410289008963 G4 box; other site 410289008964 G5 box; other site 410289008965 G1 box; other site 410289008966 Switch I region; other site 410289008967 G2 box; other site 410289008968 G3 box; other site 410289008969 Switch II region; other site 410289008970 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 410289008971 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 410289008972 putative di-iron ligands [ion binding]; other site 410289008973 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 410289008974 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 410289008975 FAD binding pocket [chemical binding]; other site 410289008976 FAD binding motif [chemical binding]; other site 410289008977 phosphate binding motif [ion binding]; other site 410289008978 beta-alpha-beta structure motif; other site 410289008979 NAD binding pocket [chemical binding]; other site 410289008980 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 410289008981 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 410289008982 catalytic loop [active] 410289008983 iron binding site [ion binding]; other site 410289008984 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 410289008985 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 410289008986 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 410289008987 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 410289008988 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 410289008989 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 410289008990 TrkA-C domain; Region: TrkA_C; pfam02080 410289008991 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 410289008992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289008993 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 410289008994 putative substrate translocation pore; other site 410289008995 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 410289008996 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 410289008997 ligand binding site [chemical binding]; other site 410289008998 flexible hinge region; other site 410289008999 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 410289009000 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 410289009001 nucleophile elbow; other site 410289009002 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 410289009003 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 410289009004 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 410289009005 30S subunit binding site; other site 410289009006 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 410289009007 active site 410289009008 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 410289009009 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 410289009010 lipoprotein LpqB; Provisional; Region: PRK13616 410289009011 Sporulation and spore germination; Region: Germane; pfam10646 410289009012 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 410289009013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 410289009014 dimerization interface [polypeptide binding]; other site 410289009015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 410289009016 dimer interface [polypeptide binding]; other site 410289009017 phosphorylation site [posttranslational modification] 410289009018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 410289009019 ATP binding site [chemical binding]; other site 410289009020 Mg2+ binding site [ion binding]; other site 410289009021 G-X-G motif; other site 410289009022 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 410289009023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 410289009024 active site 410289009025 phosphorylation site [posttranslational modification] 410289009026 intermolecular recognition site; other site 410289009027 dimerization interface [polypeptide binding]; other site 410289009028 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 410289009029 DNA binding site [nucleotide binding] 410289009030 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 410289009031 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 410289009032 TMP-binding site; other site 410289009033 ATP-binding site [chemical binding]; other site 410289009034 Adenosylhomocysteinase; Provisional; Region: PTZ00075 410289009035 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 410289009036 homotetramer interface [polypeptide binding]; other site 410289009037 ligand binding site [chemical binding]; other site 410289009038 catalytic site [active] 410289009039 NAD binding site [chemical binding]; other site 410289009040 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289009041 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 410289009042 Rubredoxin [Energy production and conversion]; Region: COG1773 410289009043 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 410289009044 iron binding site [ion binding]; other site 410289009045 Rubredoxin [Energy production and conversion]; Region: COG1773 410289009046 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 410289009047 iron binding site [ion binding]; other site 410289009048 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 410289009049 Fatty acid desaturase; Region: FA_desaturase; pfam00487 410289009050 Di-iron ligands [ion binding]; other site 410289009051 amino acid transporter; Region: 2A0306; TIGR00909 410289009052 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 410289009053 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 410289009054 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 410289009055 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 410289009056 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 410289009057 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 410289009058 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 410289009059 active site 410289009060 substrate binding site [chemical binding]; other site 410289009061 metal binding site [ion binding]; metal-binding site 410289009062 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 410289009063 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 410289009064 Transcription factor WhiB; Region: Whib; pfam02467 410289009065 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 410289009066 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 410289009067 phosphate binding site [ion binding]; other site 410289009068 dimer interface [polypeptide binding]; other site 410289009069 substrate binding site [chemical binding]; other site 410289009070 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 410289009071 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 410289009072 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 410289009073 putative FMN binding site [chemical binding]; other site 410289009074 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 410289009075 Methyltransferase domain; Region: Methyltransf_26; pfam13659 410289009076 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 410289009077 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 410289009078 active site 410289009079 Substrate binding site; other site 410289009080 Mg++ binding site; other site 410289009081 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 410289009082 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 410289009083 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 410289009084 Probable Catalytic site; other site 410289009085 metal-binding site 410289009086 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 410289009087 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 410289009088 NADP binding site [chemical binding]; other site 410289009089 active site 410289009090 putative substrate binding site [chemical binding]; other site 410289009091 Transcriptional regulator [Transcription]; Region: LytR; COG1316 410289009092 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 410289009093 TIGR03089 family protein; Region: TIGR03089 410289009094 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 410289009095 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 410289009096 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 410289009097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 410289009098 active site 410289009099 motif I; other site 410289009100 motif II; other site 410289009101 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 410289009102 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 410289009103 CoA-transferase family III; Region: CoA_transf_3; pfam02515 410289009104 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 410289009105 Sulfate transporter family; Region: Sulfate_transp; pfam00916 410289009106 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 410289009107 active site clefts [active] 410289009108 zinc binding site [ion binding]; other site 410289009109 dimer interface [polypeptide binding]; other site 410289009110 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289009111 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 410289009112 FAD binding site [chemical binding]; other site 410289009113 homotetramer interface [polypeptide binding]; other site 410289009114 substrate binding pocket [chemical binding]; other site 410289009115 catalytic base [active] 410289009116 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 410289009117 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 410289009118 ATP-grasp domain; Region: ATP-grasp; pfam02222 410289009119 Predicted membrane protein [Function unknown]; Region: COG2246 410289009120 GtrA-like protein; Region: GtrA; pfam04138 410289009121 Bacterial PH domain; Region: DUF304; pfam03703 410289009122 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 410289009123 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 410289009124 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 410289009125 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 410289009126 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 410289009127 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 410289009128 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 410289009129 Maf-like protein; Region: Maf; pfam02545 410289009130 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 410289009131 active site 410289009132 dimer interface [polypeptide binding]; other site 410289009133 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 410289009134 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 410289009135 active site residue [active] 410289009136 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 410289009137 active site residue [active] 410289009138 Fe-S metabolism associated domain; Region: SufE; pfam02657 410289009139 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 410289009140 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 410289009141 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 410289009142 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 410289009143 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 410289009144 carboxyltransferase (CT) interaction site; other site 410289009145 biotinylation site [posttranslational modification]; other site 410289009146 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 410289009147 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 410289009148 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 410289009149 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 410289009150 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 410289009151 L-lysine aminotransferase; Provisional; Region: PRK08297 410289009152 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 410289009153 inhibitor-cofactor binding pocket; inhibition site 410289009154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289009155 catalytic residue [active] 410289009156 putative DNA binding site [nucleotide binding]; other site 410289009157 dimerization interface [polypeptide binding]; other site 410289009158 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 410289009159 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 410289009160 putative Zn2+ binding site [ion binding]; other site 410289009161 AsnC family; Region: AsnC_trans_reg; pfam01037 410289009162 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 410289009163 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 410289009164 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 410289009165 tetrameric interface [polypeptide binding]; other site 410289009166 NAD binding site [chemical binding]; other site 410289009167 catalytic residues [active] 410289009168 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 410289009169 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289009170 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289009171 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 410289009172 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 410289009173 ATP binding site [chemical binding]; other site 410289009174 putative Mg++ binding site [ion binding]; other site 410289009175 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 410289009176 nucleotide binding region [chemical binding]; other site 410289009177 ATP-binding site [chemical binding]; other site 410289009178 DEAD/H associated; Region: DEAD_assoc; pfam08494 410289009179 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 410289009180 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 410289009181 putative DNA binding site [nucleotide binding]; other site 410289009182 catalytic residue [active] 410289009183 putative H2TH interface [polypeptide binding]; other site 410289009184 putative catalytic residues [active] 410289009185 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 410289009186 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 410289009187 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 410289009188 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 410289009189 Sulfatase; Region: Sulfatase; pfam00884 410289009190 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 410289009191 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 410289009192 probable active site [active] 410289009193 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 410289009194 PhoU domain; Region: PhoU; pfam01895 410289009195 PhoU domain; Region: PhoU; pfam01895 410289009196 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 410289009197 AAA domain; Region: AAA_31; pfam13614 410289009198 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 410289009199 P-loop; other site 410289009200 Magnesium ion binding site [ion binding]; other site 410289009201 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 410289009202 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 410289009203 Magnesium ion binding site [ion binding]; other site 410289009204 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 410289009205 catalytic core [active] 410289009206 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 410289009207 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 410289009208 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 410289009209 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 410289009210 Transcription factor WhiB; Region: Whib; pfam02467 410289009211 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 410289009212 PAS domain S-box; Region: sensory_box; TIGR00229 410289009213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 410289009214 Histidine kinase; Region: HisKA_2; pfam07568 410289009215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 410289009216 ATP binding site [chemical binding]; other site 410289009217 Mg2+ binding site [ion binding]; other site 410289009218 G-X-G motif; other site 410289009219 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 410289009220 carboxyltransferase (CT) interaction site; other site 410289009221 biotinylation site [posttranslational modification]; other site 410289009222 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 410289009223 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 410289009224 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 410289009225 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 410289009226 DNA binding residues [nucleotide binding] 410289009227 short chain dehydrogenase; Provisional; Region: PRK08278 410289009228 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 410289009229 NAD(P) binding site [chemical binding]; other site 410289009230 homodimer interface [polypeptide binding]; other site 410289009231 active site 410289009232 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 410289009233 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 410289009234 putative deacylase active site [active] 410289009235 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 410289009236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 410289009237 Coenzyme A binding pocket [chemical binding]; other site 410289009238 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 410289009239 Phosphotransferase enzyme family; Region: APH; pfam01636 410289009240 putative active site [active] 410289009241 putative substrate binding site [chemical binding]; other site 410289009242 ATP binding site [chemical binding]; other site 410289009243 Uncharacterized conserved protein [Function unknown]; Region: COG2135 410289009244 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 410289009245 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 410289009246 hinge; other site 410289009247 active site 410289009248 Predicted GTPases [General function prediction only]; Region: COG1162 410289009249 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 410289009250 GTPase/Zn-binding domain interface [polypeptide binding]; other site 410289009251 GTP/Mg2+ binding site [chemical binding]; other site 410289009252 G4 box; other site 410289009253 G5 box; other site 410289009254 G1 box; other site 410289009255 Switch I region; other site 410289009256 G2 box; other site 410289009257 G3 box; other site 410289009258 Switch II region; other site 410289009259 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 410289009260 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 410289009261 putative di-iron ligands [ion binding]; other site 410289009262 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 410289009263 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 410289009264 FAD binding pocket [chemical binding]; other site 410289009265 FAD binding motif [chemical binding]; other site 410289009266 phosphate binding motif [ion binding]; other site 410289009267 beta-alpha-beta structure motif; other site 410289009268 NAD binding pocket [chemical binding]; other site 410289009269 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 410289009270 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 410289009271 catalytic loop [active] 410289009272 iron binding site [ion binding]; other site 410289009273 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 410289009274 putative DNA binding site [nucleotide binding]; other site 410289009275 dimerization interface [polypeptide binding]; other site 410289009276 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 410289009277 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 410289009278 putative Zn2+ binding site [ion binding]; other site 410289009279 AsnC family; Region: AsnC_trans_reg; pfam01037 410289009280 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 410289009281 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 410289009282 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 410289009283 tetrameric interface [polypeptide binding]; other site 410289009284 NAD binding site [chemical binding]; other site 410289009285 catalytic residues [active] 410289009286 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 410289009287 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289009288 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289009289 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 410289009290 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 410289009291 ATP binding site [chemical binding]; other site 410289009292 putative Mg++ binding site [ion binding]; other site 410289009293 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 410289009294 nucleotide binding region [chemical binding]; other site 410289009295 ATP-binding site [chemical binding]; other site 410289009296 DEAD/H associated; Region: DEAD_assoc; pfam08494 410289009297 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 410289009298 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 410289009299 putative DNA binding site [nucleotide binding]; other site 410289009300 catalytic residue [active] 410289009301 putative H2TH interface [polypeptide binding]; other site 410289009302 putative catalytic residues [active] 410289009303 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 410289009304 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 410289009305 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 410289009306 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 410289009307 Sulfatase; Region: Sulfatase; pfam00884 410289009308 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 410289009309 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 410289009310 probable active site [active] 410289009311 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 410289009312 PhoU domain; Region: PhoU; pfam01895 410289009313 PhoU domain; Region: PhoU; pfam01895 410289009314 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 410289009315 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 410289009316 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 410289009317 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 410289009318 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 410289009319 putative active site pocket [active] 410289009320 dimerization interface [polypeptide binding]; other site 410289009321 putative catalytic residue [active] 410289009322 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 410289009323 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 410289009324 metal binding site [ion binding]; metal-binding site 410289009325 putative dimer interface [polypeptide binding]; other site 410289009326 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 410289009327 amidohydrolase; Region: amidohydrolases; TIGR01891 410289009328 metal binding site [ion binding]; metal-binding site 410289009329 purine nucleoside phosphorylase; Provisional; Region: PRK08202 410289009330 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 410289009331 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 410289009332 active site 410289009333 substrate binding site [chemical binding]; other site 410289009334 metal binding site [ion binding]; metal-binding site 410289009335 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 410289009336 active site 410289009337 Phosphoesterase family; Region: Phosphoesterase; pfam04185 410289009338 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 410289009339 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 410289009340 adenosine deaminase; Provisional; Region: PRK09358 410289009341 active site 410289009342 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 410289009343 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 410289009344 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 410289009345 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 410289009346 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 410289009347 active site 410289009348 catalytic motif [active] 410289009349 Zn binding site [ion binding]; other site 410289009350 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 410289009351 putative Iron-sulfur protein interface [polypeptide binding]; other site 410289009352 putative proximal heme binding site [chemical binding]; other site 410289009353 putative SdhD-like interface [polypeptide binding]; other site 410289009354 putative distal heme binding site [chemical binding]; other site 410289009355 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 410289009356 putative Iron-sulfur protein interface [polypeptide binding]; other site 410289009357 putative proximal heme binding site [chemical binding]; other site 410289009358 putative SdhC-like subunit interface [polypeptide binding]; other site 410289009359 putative distal heme binding site [chemical binding]; other site 410289009360 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 410289009361 L-aspartate oxidase; Provisional; Region: PRK06175 410289009362 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 410289009363 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 410289009364 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 410289009365 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 410289009366 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 410289009367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289009368 S-adenosylmethionine binding site [chemical binding]; other site 410289009369 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 410289009370 MoaE interaction surface [polypeptide binding]; other site 410289009371 MoeB interaction surface [polypeptide binding]; other site 410289009372 thiocarboxylated glycine; other site 410289009373 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 410289009374 MoaE homodimer interface [polypeptide binding]; other site 410289009375 MoaD interaction [polypeptide binding]; other site 410289009376 active site residues [active] 410289009377 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 410289009378 trimer interface [polypeptide binding]; other site 410289009379 dimer interface [polypeptide binding]; other site 410289009380 putative active site [active] 410289009381 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 410289009382 aromatic arch; other site 410289009383 DCoH dimer interaction site [polypeptide binding]; other site 410289009384 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 410289009385 DCoH tetramer interaction site [polypeptide binding]; other site 410289009386 substrate binding site [chemical binding]; other site 410289009387 RvD5, 4082 bp. Region of Difference RvD5, substituted region in Mycobacterium bovis BCG Pasteur (position 3698953..3703034, 4082bp) and Mycobacterium bovis AF2122/97 (position 3664904..3668985, 4082bp ) compared to Mycobacterium tuberculosis H37Rv2 (position: 3710382..3711736, 1355bp). In Mycobacterium bovis BCG Pasteur and Mycobacterium bovis AF2122/97, this region encodes genes equivalent to Mycobacterium tuberculosis strain CDC1551, MT3426-MT3429. In Mycobacterium tuberculosis strain H37Rv, insertion of an IS6110 element (encoding genes Rv3325 and Rv3326) removes genes MT3426-MT3429 410289009388 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 410289009389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 410289009390 FeS/SAM binding site; other site 410289009391 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 410289009392 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 410289009393 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 410289009394 DNA binding site [nucleotide binding] 410289009395 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 410289009396 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 410289009397 phosphopeptide binding site; other site 410289009398 Condensation domain; Region: Condensation; pfam00668 410289009399 Transposase; Region: DEDD_Tnp_IS110; pfam01548 410289009400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 410289009401 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 410289009402 Uncharacterized conserved protein [Function unknown]; Region: COG2128 410289009403 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 410289009404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 410289009405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 410289009406 DNA binding residues [nucleotide binding] 410289009407 SnoaL-like domain; Region: SnoaL_2; pfam12680 410289009408 hypothetical protein; Provisional; Region: PRK06541 410289009409 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 410289009410 inhibitor-cofactor binding pocket; inhibition site 410289009411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289009412 catalytic residue [active] 410289009413 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 410289009414 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 410289009415 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 410289009416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289009417 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 410289009418 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 410289009419 active site 410289009420 dimer interface [polypeptide binding]; other site 410289009421 Protein of unknown function (DUF732); Region: DUF732; pfam05305 410289009422 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 410289009423 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 410289009424 DNA binding residues [nucleotide binding] 410289009425 dimer interface [polypeptide binding]; other site 410289009426 metal binding site [ion binding]; metal-binding site 410289009427 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 410289009428 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 410289009429 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 410289009430 active site 410289009431 HIGH motif; other site 410289009432 dimer interface [polypeptide binding]; other site 410289009433 KMSKS motif; other site 410289009434 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 410289009435 isocitrate dehydrogenase; Validated; Region: PRK08299 410289009436 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 410289009437 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 410289009438 homodimer interface [polypeptide binding]; other site 410289009439 substrate-cofactor binding pocket; other site 410289009440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289009441 catalytic residue [active] 410289009442 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 410289009443 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 410289009444 Methyltransferase domain; Region: Methyltransf_23; pfam13489 410289009445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289009446 S-adenosylmethionine binding site [chemical binding]; other site 410289009447 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289009448 PPE family; Region: PPE; pfam00823 410289009449 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289009450 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289009451 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289009452 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289009453 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289009454 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289009455 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289009456 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289009457 RD19, 3555 bp. Region of Difference RD19, deleted region in Mycobacterium bovis BCG Pasteur (position 3723542..3723543) and Mycobacterium bovis AF2122/97 (position 3689508..3689509) compared to Mycobacterium tuberculosis H37Rv2 (position: 3732259..3735813). Internal in-frame deletion of PPE54, Rv3343c 410289009458 PE family; Region: PE; pfam00934 410289009459 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 410289009460 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289009461 PPE family; Region: PPE; pfam00823 410289009462 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289009463 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289009464 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289009465 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289009466 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289009467 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289009468 Transposase; Region: DEDD_Tnp_IS110; pfam01548 410289009469 Transposase; Region: DDE_Tnp_ISL3; pfam01610 410289009470 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289009471 PPE family; Region: PPE; pfam00823 410289009472 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289009473 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289009474 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289009475 Berberine and berberine like; Region: BBE; pfam08031 410289009476 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 410289009477 Protein of unknown function (DUF732); Region: DUF732; pfam05305 410289009478 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 410289009479 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 410289009480 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 410289009481 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 410289009482 homodimer interface [polypeptide binding]; other site 410289009483 NADP binding site [chemical binding]; other site 410289009484 substrate binding site [chemical binding]; other site 410289009485 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 410289009486 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 410289009487 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 410289009488 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 410289009489 active site 410289009490 FMN binding site [chemical binding]; other site 410289009491 substrate binding site [chemical binding]; other site 410289009492 putative catalytic residue [active] 410289009493 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 410289009494 phosphate binding site [ion binding]; other site 410289009495 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 410289009496 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 410289009497 phosphopeptide binding site; other site 410289009498 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 410289009499 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 410289009500 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 410289009501 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 410289009502 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 410289009503 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 410289009504 G1 box; other site 410289009505 GTP/Mg2+ binding site [chemical binding]; other site 410289009506 G2 box; other site 410289009507 Switch I region; other site 410289009508 G3 box; other site 410289009509 Switch II region; other site 410289009510 G4 box; other site 410289009511 G5 box; other site 410289009512 Protein of unknown function (DUF742); Region: DUF742; pfam05331 410289009513 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 410289009514 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 410289009515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 410289009516 ATP binding site [chemical binding]; other site 410289009517 Mg2+ binding site [ion binding]; other site 410289009518 G-X-G motif; other site 410289009519 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 410289009520 PE family; Region: PE; pfam00934 410289009521 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 410289009522 FMN binding site [chemical binding]; other site 410289009523 dimer interface [polypeptide binding]; other site 410289009524 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 410289009525 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 410289009526 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 410289009527 active site 410289009528 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 410289009529 generic binding surface II; other site 410289009530 generic binding surface I; other site 410289009531 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 410289009532 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 410289009533 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 410289009534 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 410289009535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 410289009536 active site 410289009537 motif I; other site 410289009538 motif II; other site 410289009539 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 410289009540 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289009541 substrate binding site [chemical binding]; other site 410289009542 oxyanion hole (OAH) forming residues; other site 410289009543 trimer interface [polypeptide binding]; other site 410289009544 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 410289009545 Amidase; Region: Amidase; pfam01425 410289009546 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 410289009547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 410289009548 motif II; other site 410289009549 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 410289009550 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 410289009551 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 410289009552 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 410289009553 TPP-binding site; other site 410289009554 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 410289009555 PYR/PP interface [polypeptide binding]; other site 410289009556 dimer interface [polypeptide binding]; other site 410289009557 TPP binding site [chemical binding]; other site 410289009558 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 410289009559 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 410289009560 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 410289009561 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 410289009562 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 410289009563 substrate binding pocket [chemical binding]; other site 410289009564 chain length determination region; other site 410289009565 substrate-Mg2+ binding site; other site 410289009566 catalytic residues [active] 410289009567 aspartate-rich region 1; other site 410289009568 active site lid residues [active] 410289009569 aspartate-rich region 2; other site 410289009570 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 410289009571 putative active site [active] 410289009572 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 410289009573 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 410289009574 Transposase domain (DUF772); Region: DUF772; pfam05598 410289009575 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 410289009576 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 410289009577 PE family; Region: PE; pfam00934 410289009578 enoyl-CoA hydratase; Region: PLN02864 410289009579 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 410289009580 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 410289009581 dimer interaction site [polypeptide binding]; other site 410289009582 substrate-binding tunnel; other site 410289009583 active site 410289009584 catalytic site [active] 410289009585 substrate binding site [chemical binding]; other site 410289009586 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 410289009587 short chain dehydrogenase; Provisional; Region: PRK07201 410289009588 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 410289009589 putative NAD(P) binding site [chemical binding]; other site 410289009590 active site 410289009591 putative substrate binding site [chemical binding]; other site 410289009592 classical (c) SDRs; Region: SDR_c; cd05233 410289009593 NAD(P) binding site [chemical binding]; other site 410289009594 active site 410289009595 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 410289009596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289009597 S-adenosylmethionine binding site [chemical binding]; other site 410289009598 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 410289009599 active site 410289009600 DNA Polymerase Y-family; Region: PolY_like; cd03468 410289009601 DNA binding site [nucleotide binding] 410289009602 GMP synthase; Reviewed; Region: guaA; PRK00074 410289009603 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 410289009604 AMP/PPi binding site [chemical binding]; other site 410289009605 candidate oxyanion hole; other site 410289009606 catalytic triad [active] 410289009607 potential glutamine specificity residues [chemical binding]; other site 410289009608 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 410289009609 ATP Binding subdomain [chemical binding]; other site 410289009610 Ligand Binding sites [chemical binding]; other site 410289009611 Dimerization subdomain; other site 410289009612 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 410289009613 active site lid residues [active] 410289009614 substrate binding pocket [chemical binding]; other site 410289009615 catalytic residues [active] 410289009616 substrate-Mg2+ binding site; other site 410289009617 aspartate-rich region 1; other site 410289009618 aspartate-rich region 2; other site 410289009619 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 410289009620 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 410289009621 substrate binding pocket [chemical binding]; other site 410289009622 chain length determination region; other site 410289009623 substrate-Mg2+ binding site; other site 410289009624 catalytic residues [active] 410289009625 aspartate-rich region 1; other site 410289009626 active site lid residues [active] 410289009627 aspartate-rich region 2; other site 410289009628 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 410289009629 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 410289009630 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 410289009631 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 410289009632 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 410289009633 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 410289009634 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 410289009635 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 410289009636 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 410289009637 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 410289009638 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 410289009639 catalytic residue [active] 410289009640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 410289009641 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 410289009642 hypothetical protein; Provisional; Region: PRK07579 410289009643 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 410289009644 active site 410289009645 cosubstrate binding site; other site 410289009646 substrate binding site [chemical binding]; other site 410289009647 catalytic site [active] 410289009648 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289009649 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289009650 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 410289009651 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 410289009652 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 410289009653 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 410289009654 putative active site [active] 410289009655 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 410289009656 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 410289009657 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 410289009658 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 410289009659 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 410289009660 phosphate binding site [ion binding]; other site 410289009661 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 410289009662 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 410289009663 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 410289009664 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 410289009665 active site 410289009666 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 410289009667 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 410289009668 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 410289009669 DNA binding residues [nucleotide binding] 410289009670 Transcription factor WhiB; Region: Whib; pfam02467 410289009671 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 410289009672 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 410289009673 ring oligomerisation interface [polypeptide binding]; other site 410289009674 ATP/Mg binding site [chemical binding]; other site 410289009675 stacking interactions; other site 410289009676 hinge regions; other site 410289009677 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 410289009678 oligomerisation interface [polypeptide binding]; other site 410289009679 mobile loop; other site 410289009680 roof hairpin; other site 410289009681 UGMP family protein; Validated; Region: PRK09604 410289009682 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 410289009683 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 410289009684 Coenzyme A binding pocket [chemical binding]; other site 410289009685 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 410289009686 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 410289009687 alanine racemase; Reviewed; Region: alr; PRK00053 410289009688 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 410289009689 active site 410289009690 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 410289009691 dimer interface [polypeptide binding]; other site 410289009692 substrate binding site [chemical binding]; other site 410289009693 catalytic residues [active] 410289009694 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289009695 PPE family; Region: PPE; pfam00823 410289009696 RD6, 4926 bp. Region of Difference RD6, deleted region in Mycobacterium bovis BCG Pasteur (position 3829069..3829070) and Mycobacterium bovis AF2122/97 (position 3795195..3795196) compared to Mycobacterium tuberculosis H37Rv2 (position: 3842568..3847493) . Removes genes Rv3426-Rv3428 and merges truncated genes Rv3425 and Rv3429 410289009697 Integrase core domain; Region: rve; pfam00665 410289009698 Integrase core domain; Region: rve_3; pfam13683 410289009699 Transposase, Mutator family; Region: Transposase_mut; pfam00872 410289009700 MULE transposase domain; Region: MULE; pfam10551 410289009701 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 410289009702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289009703 catalytic residue [active] 410289009704 Uncharacterized conserved protein [Function unknown]; Region: COG0062 410289009705 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 410289009706 putative substrate binding site [chemical binding]; other site 410289009707 putative ATP binding site [chemical binding]; other site 410289009708 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 410289009709 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 410289009710 glutaminase active site [active] 410289009711 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 410289009712 dimer interface [polypeptide binding]; other site 410289009713 active site 410289009714 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 410289009715 dimer interface [polypeptide binding]; other site 410289009716 active site 410289009717 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 410289009718 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 410289009719 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 410289009720 active site 410289009721 substrate binding site [chemical binding]; other site 410289009722 metal binding site [ion binding]; metal-binding site 410289009723 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 410289009724 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 410289009725 23S rRNA interface [nucleotide binding]; other site 410289009726 L3 interface [polypeptide binding]; other site 410289009727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 410289009728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 410289009729 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 410289009730 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 410289009731 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 410289009732 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 410289009733 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 410289009734 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 410289009735 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 410289009736 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 410289009737 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 410289009738 active site 410289009739 catalytic residues [active] 410289009740 Protein of unknown function (DUF690); Region: DUF690; pfam05108 410289009741 Cutinase; Region: Cutinase; pfam01083 410289009742 Cutinase; Region: Cutinase; pfam01083 410289009743 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 410289009744 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 410289009745 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 410289009746 active site 410289009747 dimerization interface 3.5A [polypeptide binding]; other site 410289009748 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 410289009749 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 410289009750 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 410289009751 alphaNTD - beta interaction site [polypeptide binding]; other site 410289009752 alphaNTD homodimer interface [polypeptide binding]; other site 410289009753 alphaNTD - beta' interaction site [polypeptide binding]; other site 410289009754 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 410289009755 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 410289009756 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 410289009757 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 410289009758 RNA binding surface [nucleotide binding]; other site 410289009759 30S ribosomal protein S11; Validated; Region: PRK05309 410289009760 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 410289009761 30S ribosomal protein S13; Region: bact_S13; TIGR03631 410289009762 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 410289009763 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 410289009764 rRNA binding site [nucleotide binding]; other site 410289009765 predicted 30S ribosome binding site; other site 410289009766 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 410289009767 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 410289009768 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 410289009769 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 410289009770 NAD binding site [chemical binding]; other site 410289009771 substrate binding site [chemical binding]; other site 410289009772 homodimer interface [polypeptide binding]; other site 410289009773 active site 410289009774 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 410289009775 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289009776 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289009777 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289009778 active site 410289009779 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 410289009780 extended (e) SDRs; Region: SDR_e; cd08946 410289009781 NAD(P) binding site [chemical binding]; other site 410289009782 active site 410289009783 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 410289009784 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 410289009785 active site 410289009786 catalytic residues [active] 410289009787 metal binding site [ion binding]; metal-binding site 410289009788 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 410289009789 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 410289009790 PYR/PP interface [polypeptide binding]; other site 410289009791 dimer interface [polypeptide binding]; other site 410289009792 TPP binding site [chemical binding]; other site 410289009793 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 410289009794 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 410289009795 TPP-binding site [chemical binding]; other site 410289009796 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 410289009797 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 410289009798 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 410289009799 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 410289009800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289009801 metabolite-proton symporter; Region: 2A0106; TIGR00883 410289009802 putative substrate translocation pore; other site 410289009803 PE family; Region: PE; pfam00934 410289009804 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289009805 PPE family; Region: PPE; pfam00823 410289009806 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 410289009807 patatin-related protein; Region: TIGR03607 410289009808 RD18, 713 bp. Region of Difference RD18, deleted region in Mycobacterium bovis BCG Pasteur (position 3877283..3877284) and Mycobacterium bovis AF2122/97 (position 3843412..3843413) compared to Mycobacterium tuberculosis H37Rv2 (position: 3897075-3897787). Breaks Rv3479 into 2 genes 410289009809 Protein of unknown function (DUF3376); Region: DUF3376; pfam11856 410289009810 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 410289009811 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 410289009812 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 410289009813 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 410289009814 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 410289009815 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 410289009816 Transcriptional regulator [Transcription]; Region: LytR; COG1316 410289009817 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 410289009818 short chain dehydrogenase; Provisional; Region: PRK05875 410289009819 classical (c) SDRs; Region: SDR_c; cd05233 410289009820 NAD(P) binding site [chemical binding]; other site 410289009821 active site 410289009822 Predicted membrane protein [Function unknown]; Region: COG2259 410289009823 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 410289009824 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 410289009825 Predicted transcriptional regulators [Transcription]; Region: COG1695 410289009826 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 410289009827 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 410289009828 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 410289009829 active site 410289009830 homotetramer interface [polypeptide binding]; other site 410289009831 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289009832 mce related protein; Region: MCE; pfam02470 410289009833 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289009834 mce related protein; Region: MCE; pfam02470 410289009835 mce related protein; Region: MCE; pfam02470 410289009836 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289009837 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 410289009838 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289009839 mce related protein; Region: MCE; pfam02470 410289009840 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289009841 mce related protein; Region: MCE; pfam02470 410289009842 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 410289009843 mce related protein; Region: MCE; pfam02470 410289009844 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 410289009845 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 410289009846 Permease; Region: Permease; pfam02405 410289009847 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 410289009848 Permease; Region: Permease; pfam02405 410289009849 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 410289009850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289009851 NAD(P) binding site [chemical binding]; other site 410289009852 active site 410289009853 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 410289009854 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 410289009855 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289009856 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 410289009857 FAD binding site [chemical binding]; other site 410289009858 substrate binding site [chemical binding]; other site 410289009859 catalytic base [active] 410289009860 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289009861 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289009862 active site 410289009863 acyl-CoA synthetase; Validated; Region: PRK07867 410289009864 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 410289009865 acyl-activating enzyme (AAE) consensus motif; other site 410289009866 putative AMP binding site [chemical binding]; other site 410289009867 putative active site [active] 410289009868 putative CoA binding site [chemical binding]; other site 410289009869 PE family; Region: PE; pfam00934 410289009870 PE family; Region: PE; pfam00934 410289009871 RD20, 603 bp. Region of Difference RD20, deleted region in Mycobacterium bovis BCG Pasteur (position 3913496..3913497) and Mycobacterium bovis AF2122/97 (position 3879493..3879494) compared to Mycobacterium tuberculosis H37Rv2 (position: 3933940..3934542). In-frame deletion in PE_PGRS54 gene 410289009872 I-RD10, 1152 bp. Region of Difference I-RD10, inserted region of 1152bp (position 3915236..3916387, 1152bp), in Mycobacterium bovis BCG Pasteur, compared to Mycobacterium tuberculosis H37Rv2 (position: 3936338..3936339) and of 1827bp (position 3914354..3916180, 1827bp) compared to Mycobacterium bovis AF2122/97 (position 3880368..3880369). In-frame insertion in PE_PGRS54 gene 410289009873 hypothetical protein; Validated; Region: PRK07586 410289009874 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 410289009875 PYR/PP interface [polypeptide binding]; other site 410289009876 dimer interface [polypeptide binding]; other site 410289009877 TPP binding site [chemical binding]; other site 410289009878 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 410289009879 TPP-binding site [chemical binding]; other site 410289009880 dimer interface [polypeptide binding]; other site 410289009881 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 410289009882 PE family; Region: PE; pfam00934 410289009883 I-RD11, 344 bp. Region of Difference I-RD11, inserted region in Mycobacterium bovis BCG Pasteur (position 3921785..3922128, 344bp) and Mycobacterium bovis AF2122/97 (position 3885973..3886316, 344bp) compared to Mycobacterium tuberculosis H37Rv2 (position: 3941726..3941727). Merges PE_PGRS55(Rv3511) and PE_PGRS56(Rv3512) in a single gene, PE_PGRS55 410289009884 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289009885 CoA binding site [chemical binding]; other site 410289009886 PE family; Region: PE; pfam00934 410289009887 S-RD12, 925 bp. Region of Difference S-RD12, substituted region in Mycobacterium bovis BCG Pasteur (position 3927720..3928644, 925bp) and Mycobacterium bovis AF2122/97 (position 3892403..3892967, 565bp) compared to Mycobacterium tuberculosis H37Rv2 (position 3947672..3949750, 2079bp). In Mycobacterium bovis BCG Pasteur, an in-frame insertion of 360bp in PE_PGRS57 gene leads to a longer product compared to Mycobacterium bovis AF2122/97 ones 410289009888 acyl-CoA synthetase; Validated; Region: PRK07798 410289009889 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289009890 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 410289009891 acyl-activating enzyme (AAE) consensus motif; other site 410289009892 acyl-activating enzyme (AAE) consensus motif; other site 410289009893 putative AMP binding site [chemical binding]; other site 410289009894 putative active site [active] 410289009895 putative CoA binding site [chemical binding]; other site 410289009896 enoyl-CoA hydratase; Provisional; Region: PRK07799 410289009897 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289009898 substrate binding site [chemical binding]; other site 410289009899 oxyanion hole (OAH) forming residues; other site 410289009900 trimer interface [polypeptide binding]; other site 410289009901 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 410289009902 Cytochrome P450; Region: p450; cl12078 410289009903 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289009904 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289009905 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 410289009906 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 410289009907 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 410289009908 DUF35 OB-fold domain; Region: DUF35; pfam01796 410289009909 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 410289009910 DUF35 OB-fold domain; Region: DUF35; pfam01796 410289009911 lipid-transfer protein; Provisional; Region: PRK07937 410289009912 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 410289009913 active site 410289009914 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 410289009915 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 410289009916 active site 410289009917 NHL repeat; Region: NHL; pfam01436 410289009918 Uncharacterized conserved protein [Function unknown]; Region: COG3391 410289009919 NHL repeat; Region: NHL; pfam01436 410289009920 NHL repeat; Region: NHL; pfam01436 410289009921 NHL repeat; Region: NHL; pfam01436 410289009922 NHL repeat; Region: NHL; pfam01436 410289009923 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 410289009924 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 410289009925 trimer interface [polypeptide binding]; other site 410289009926 putative metal binding site [ion binding]; other site 410289009927 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 410289009928 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 410289009929 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 410289009930 short chain dehydrogenase; Provisional; Region: PRK07890 410289009931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289009932 NAD(P) binding site [chemical binding]; other site 410289009933 active site 410289009934 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289009935 PPE family; Region: PPE; pfam00823 410289009936 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 410289009937 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289009938 PPE family; Region: PPE; pfam00823 410289009939 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289009940 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 410289009941 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 410289009942 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 410289009943 active site 410289009944 catalytic residues [active] 410289009945 metal binding site [ion binding]; metal-binding site 410289009946 DmpG-like communication domain; Region: DmpG_comm; pfam07836 410289009947 acetaldehyde dehydrogenase; Validated; Region: PRK08300 410289009948 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 410289009949 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 410289009950 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 410289009951 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 410289009952 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 410289009953 enoyl-CoA hydratase; Region: PLN02864 410289009954 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 410289009955 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 410289009956 dimer interaction site [polypeptide binding]; other site 410289009957 substrate-binding tunnel; other site 410289009958 active site 410289009959 catalytic site [active] 410289009960 substrate binding site [chemical binding]; other site 410289009961 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289009962 PPE family; Region: PPE; pfam00823 410289009963 PE-PPE domain; Region: PE-PPE; pfam08237 410289009964 lipid-transfer protein; Provisional; Region: PRK07855 410289009965 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 410289009966 active site 410289009967 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 410289009968 putative active site [active] 410289009969 putative catalytic site [active] 410289009970 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 410289009971 active site 410289009972 catalytic site [active] 410289009973 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 410289009974 DUF35 OB-fold domain; Region: DUF35; pfam01796 410289009975 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289009976 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289009977 active site 410289009978 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289009979 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 410289009980 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289009981 active site 410289009982 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289009983 Cytochrome P450; Region: p450; cl12078 410289009984 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 410289009985 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 410289009986 dimer interface [polypeptide binding]; other site 410289009987 active site 410289009988 Domain of unknown function (DUF385); Region: DUF385; pfam04075 410289009989 short chain dehydrogenase; Provisional; Region: PRK07791 410289009990 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 410289009991 homodimer interface [polypeptide binding]; other site 410289009992 NAD binding site [chemical binding]; other site 410289009993 active site 410289009994 short chain dehydrogenase; Provisional; Region: PRK07856 410289009995 classical (c) SDRs; Region: SDR_c; cd05233 410289009996 NAD(P) binding site [chemical binding]; other site 410289009997 active site 410289009998 enoyl-CoA hydratase; Provisional; Region: PRK06495 410289009999 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289010000 substrate binding site [chemical binding]; other site 410289010001 oxyanion hole (OAH) forming residues; other site 410289010002 trimer interface [polypeptide binding]; other site 410289010003 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 410289010004 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 410289010005 Nitronate monooxygenase; Region: NMO; pfam03060 410289010006 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 410289010007 FMN binding site [chemical binding]; other site 410289010008 substrate binding site [chemical binding]; other site 410289010009 putative catalytic residue [active] 410289010010 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 410289010011 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 410289010012 putative di-iron ligands [ion binding]; other site 410289010013 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 410289010014 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 410289010015 FAD binding pocket [chemical binding]; other site 410289010016 FAD binding motif [chemical binding]; other site 410289010017 phosphate binding motif [ion binding]; other site 410289010018 beta-alpha-beta structure motif; other site 410289010019 NAD(p) ribose binding residues [chemical binding]; other site 410289010020 NAD binding pocket [chemical binding]; other site 410289010021 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 410289010022 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 410289010023 catalytic loop [active] 410289010024 iron binding site [ion binding]; other site 410289010025 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 410289010026 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 410289010027 putative active site [active] 410289010028 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 410289010029 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 410289010030 dimer interface [polypeptide binding]; other site 410289010031 active site 410289010032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289010033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289010034 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 410289010035 PPE family; Region: PPE; pfam00823 410289010036 short chain dehydrogenase; Provisional; Region: PRK07831 410289010037 classical (c) SDRs; Region: SDR_c; cd05233 410289010038 NAD(P) binding site [chemical binding]; other site 410289010039 active site 410289010040 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289010041 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289010042 active site 410289010043 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 410289010044 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 410289010045 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 410289010046 acyl-activating enzyme (AAE) consensus motif; other site 410289010047 putative AMP binding site [chemical binding]; other site 410289010048 putative active site [active] 410289010049 putative CoA binding site [chemical binding]; other site 410289010050 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289010051 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289010052 active site 410289010053 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289010054 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 410289010055 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289010056 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289010057 active site 410289010058 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289010059 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 410289010060 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289010061 active site 410289010062 aspartate aminotransferase; Provisional; Region: PRK05764 410289010063 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 410289010064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289010065 homodimer interface [polypeptide binding]; other site 410289010066 catalytic residue [active] 410289010067 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 410289010068 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 410289010069 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 410289010070 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 410289010071 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 410289010072 active site 410289010073 Fe binding site [ion binding]; other site 410289010074 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 410289010075 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289010076 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 410289010077 Flavin binding site [chemical binding]; other site 410289010078 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 410289010079 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 410289010080 FAD binding pocket [chemical binding]; other site 410289010081 FAD binding motif [chemical binding]; other site 410289010082 phosphate binding motif [ion binding]; other site 410289010083 beta-alpha-beta structure motif; other site 410289010084 NAD(p) ribose binding residues [chemical binding]; other site 410289010085 NAD binding pocket [chemical binding]; other site 410289010086 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 410289010087 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 410289010088 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 410289010089 catalytic loop [active] 410289010090 iron binding site [ion binding]; other site 410289010091 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289010092 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289010093 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 410289010094 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289010095 active site 410289010096 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289010097 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289010098 Transcriptional regulators [Transcription]; Region: PurR; COG1609 410289010099 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 410289010100 DNA binding site [nucleotide binding] 410289010101 domain linker motif; other site 410289010102 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 410289010103 putative dimerization interface [polypeptide binding]; other site 410289010104 putative ligand binding site [chemical binding]; other site 410289010105 PknH-like extracellular domain; Region: PknH_C; pfam14032 410289010106 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 410289010107 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 410289010108 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 410289010109 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 410289010110 transmembrane helices; other site 410289010111 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 410289010112 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 410289010113 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 410289010114 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 410289010115 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 410289010116 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 410289010117 active site 410289010118 HIGH motif; other site 410289010119 nucleotide binding site [chemical binding]; other site 410289010120 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 410289010121 KMSKS motif; other site 410289010122 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 410289010123 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 410289010124 homotrimer interaction site [polypeptide binding]; other site 410289010125 zinc binding site [ion binding]; other site 410289010126 CDP-binding sites; other site 410289010127 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 410289010128 substrate binding site; other site 410289010129 dimer interface; other site 410289010130 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 410289010131 DNA repair protein RadA; Provisional; Region: PRK11823 410289010132 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 410289010133 Walker A motif/ATP binding site; other site 410289010134 ATP binding site [chemical binding]; other site 410289010135 Walker B motif; other site 410289010136 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 410289010137 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 410289010138 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 410289010139 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 410289010140 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 410289010141 active site clefts [active] 410289010142 zinc binding site [ion binding]; other site 410289010143 dimer interface [polypeptide binding]; other site 410289010144 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 410289010145 endonuclease III; Region: ENDO3c; smart00478 410289010146 minor groove reading motif; other site 410289010147 helix-hairpin-helix signature motif; other site 410289010148 substrate binding pocket [chemical binding]; other site 410289010149 active site 410289010150 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 410289010151 PE family; Region: PE; pfam00934 410289010152 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 410289010153 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 410289010154 catalytic site [active] 410289010155 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 410289010156 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 410289010157 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 410289010158 Ami_2 domain; Region: Ami_2; smart00644 410289010159 amidase catalytic site [active] 410289010160 Zn binding residues [ion binding]; other site 410289010161 substrate binding site [chemical binding]; other site 410289010162 PE family; Region: PE; pfam00934 410289010163 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 410289010164 Clp amino terminal domain; Region: Clp_N; pfam02861 410289010165 Clp amino terminal domain; Region: Clp_N; pfam02861 410289010166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289010167 Walker A motif; other site 410289010168 ATP binding site [chemical binding]; other site 410289010169 Walker B motif; other site 410289010170 arginine finger; other site 410289010171 UvrB/uvrC motif; Region: UVR; pfam02151 410289010172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289010173 Walker A motif; other site 410289010174 ATP binding site [chemical binding]; other site 410289010175 Walker B motif; other site 410289010176 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 410289010177 Lsr2; Region: Lsr2; pfam11774 410289010178 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 410289010179 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 410289010180 dimer interface [polypeptide binding]; other site 410289010181 putative anticodon binding site; other site 410289010182 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 410289010183 motif 1; other site 410289010184 dimer interface [polypeptide binding]; other site 410289010185 active site 410289010186 motif 2; other site 410289010187 motif 3; other site 410289010188 pantothenate kinase; Reviewed; Region: PRK13318 410289010189 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 410289010190 tetramerization interface [polypeptide binding]; other site 410289010191 active site 410289010192 Pantoate-beta-alanine ligase; Region: PanC; cd00560 410289010193 pantoate--beta-alanine ligase; Region: panC; TIGR00018 410289010194 active site 410289010195 ATP-binding site [chemical binding]; other site 410289010196 pantoate-binding site; other site 410289010197 HXXH motif; other site 410289010198 Rossmann-like domain; Region: Rossmann-like; pfam10727 410289010199 Uncharacterized conserved protein [Function unknown]; Region: COG5495 410289010200 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 410289010201 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 410289010202 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 410289010203 catalytic center binding site [active] 410289010204 ATP binding site [chemical binding]; other site 410289010205 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 410289010206 homooctamer interface [polypeptide binding]; other site 410289010207 active site 410289010208 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 410289010209 dihydropteroate synthase; Region: DHPS; TIGR01496 410289010210 substrate binding pocket [chemical binding]; other site 410289010211 dimer interface [polypeptide binding]; other site 410289010212 inhibitor binding site; inhibition site 410289010213 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 410289010214 homodecamer interface [polypeptide binding]; other site 410289010215 GTP cyclohydrolase I; Provisional; Region: PLN03044 410289010216 active site 410289010217 putative catalytic site residues [active] 410289010218 zinc binding site [ion binding]; other site 410289010219 GTP-CH-I/GFRP interaction surface; other site 410289010220 FtsH Extracellular; Region: FtsH_ext; pfam06480 410289010221 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 410289010222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289010223 Walker A motif; other site 410289010224 ATP binding site [chemical binding]; other site 410289010225 Walker B motif; other site 410289010226 arginine finger; other site 410289010227 Peptidase family M41; Region: Peptidase_M41; pfam01434 410289010228 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 410289010229 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 410289010230 RD8, 5894 bp. Region of Difference RD8, deleted region in Mycobacterium bovis BCG Pasteur (position 4035754..4035755) and Mycobacterium bovis AF2122/97 (position 3999970..3999971) compared to Mycobacterium tuberculosis H37Rv2 (position: 4056840..4062733). Removes genes Rv3617-Rv3622c and truncates Rv3623 410289010231 Uncharacterized conserved protein [Function unknown]; Region: COG2968 410289010232 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 410289010233 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 410289010234 active site 410289010235 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 410289010236 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 410289010237 Ligand Binding Site [chemical binding]; other site 410289010238 Uncharacterized conserved protein [Function unknown]; Region: COG5282 410289010239 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 410289010240 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 410289010241 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 410289010242 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 410289010243 dimer interface [polypeptide binding]; other site 410289010244 substrate binding site [chemical binding]; other site 410289010245 metal binding sites [ion binding]; metal-binding site 410289010246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 410289010247 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 410289010248 Ligand binding site; other site 410289010249 Putative Catalytic site; other site 410289010250 DXD motif; other site 410289010251 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 410289010252 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 410289010253 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 410289010254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289010255 NAD(P) binding site [chemical binding]; other site 410289010256 active site 410289010257 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 410289010258 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 410289010259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 410289010260 transposase; Provisional; Region: PRK06526 410289010261 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 410289010262 Walker B motif; other site 410289010263 Transposase, Mutator family; Region: Transposase_mut; pfam00872 410289010264 MULE transposase domain; Region: MULE; pfam10551 410289010265 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 410289010266 Fic/DOC family; Region: Fic; cl00960 410289010267 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 410289010268 DNA polymerase III subunit delta'; Validated; Region: PRK07940 410289010269 DNA polymerase III subunit delta'; Validated; Region: PRK08485 410289010270 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 410289010271 dimerization interface [polypeptide binding]; other site 410289010272 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 410289010273 cyclase homology domain; Region: CHD; cd07302 410289010274 nucleotidyl binding site; other site 410289010275 metal binding site [ion binding]; metal-binding site 410289010276 dimer interface [polypeptide binding]; other site 410289010277 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 410289010278 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 410289010279 active site 410289010280 interdomain interaction site; other site 410289010281 putative metal-binding site [ion binding]; other site 410289010282 nucleotide binding site [chemical binding]; other site 410289010283 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 410289010284 domain I; other site 410289010285 phosphate binding site [ion binding]; other site 410289010286 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 410289010287 domain II; other site 410289010288 domain III; other site 410289010289 nucleotide binding site [chemical binding]; other site 410289010290 DNA binding groove [nucleotide binding] 410289010291 catalytic site [active] 410289010292 domain IV; other site 410289010293 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 410289010294 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 410289010295 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 410289010296 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 410289010297 DNA-binding site [nucleotide binding]; DNA binding site 410289010298 RNA-binding motif; other site 410289010299 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 410289010300 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 410289010301 ATP binding site [chemical binding]; other site 410289010302 putative Mg++ binding site [ion binding]; other site 410289010303 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 410289010304 nucleotide binding region [chemical binding]; other site 410289010305 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 410289010306 PE family; Region: PE; pfam00934 410289010307 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 410289010308 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 410289010309 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 410289010310 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 410289010311 Walker A motif; other site 410289010312 hexamer interface [polypeptide binding]; other site 410289010313 ATP binding site [chemical binding]; other site 410289010314 Walker B motif; other site 410289010315 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 410289010316 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 410289010317 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 410289010318 motif II; other site 410289010319 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 410289010320 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 410289010321 Walker A/P-loop; other site 410289010322 ATP binding site [chemical binding]; other site 410289010323 Q-loop/lid; other site 410289010324 ABC transporter signature motif; other site 410289010325 Walker B; other site 410289010326 D-loop; other site 410289010327 H-loop/switch region; other site 410289010328 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 410289010329 Walker A/P-loop; other site 410289010330 ATP binding site [chemical binding]; other site 410289010331 Q-loop/lid; other site 410289010332 ABC transporter signature motif; other site 410289010333 Walker B; other site 410289010334 D-loop; other site 410289010335 H-loop/switch region; other site 410289010336 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 410289010337 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 410289010338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289010339 ABC-ATPase subunit interface; other site 410289010340 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 410289010341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289010342 dimer interface [polypeptide binding]; other site 410289010343 conserved gate region; other site 410289010344 ABC-ATPase subunit interface; other site 410289010345 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 410289010346 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 410289010347 acetyl-CoA synthetase; Provisional; Region: PRK00174 410289010348 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 410289010349 active site 410289010350 CoA binding site [chemical binding]; other site 410289010351 acyl-activating enzyme (AAE) consensus motif; other site 410289010352 AMP binding site [chemical binding]; other site 410289010353 acetate binding site [chemical binding]; other site 410289010354 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 410289010355 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 410289010356 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 410289010357 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 410289010358 putative active site [active] 410289010359 putative CoA binding site [chemical binding]; other site 410289010360 nudix motif; other site 410289010361 metal binding site [ion binding]; metal-binding site 410289010362 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 410289010363 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 410289010364 catalytic residues [active] 410289010365 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 410289010366 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 410289010367 minor groove reading motif; other site 410289010368 helix-hairpin-helix signature motif; other site 410289010369 substrate binding pocket [chemical binding]; other site 410289010370 active site 410289010371 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 410289010372 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 410289010373 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 410289010374 ligand binding site [chemical binding]; other site 410289010375 flexible hinge region; other site 410289010376 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 410289010377 putative switch regulator; other site 410289010378 non-specific DNA interactions [nucleotide binding]; other site 410289010379 DNA binding site [nucleotide binding] 410289010380 sequence specific DNA binding site [nucleotide binding]; other site 410289010381 putative cAMP binding site [chemical binding]; other site 410289010382 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 410289010383 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 410289010384 homotrimer interaction site [polypeptide binding]; other site 410289010385 putative active site [active] 410289010386 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 410289010387 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 410289010388 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 410289010389 P loop; other site 410289010390 Nucleotide binding site [chemical binding]; other site 410289010391 DTAP/Switch II; other site 410289010392 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 410289010393 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 410289010394 DTAP/Switch II; other site 410289010395 Switch I; other site 410289010396 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 410289010397 Transcription factor WhiB; Region: Whib; pfam02467 410289010398 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 410289010399 Transglycosylase; Region: Transgly; pfam00912 410289010400 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 410289010401 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 410289010402 phosphodiesterase YaeI; Provisional; Region: PRK11340 410289010403 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 410289010404 putative active site [active] 410289010405 putative metal binding site [ion binding]; other site 410289010406 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 410289010407 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 410289010408 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 410289010409 catalytic residue [active] 410289010410 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 410289010411 Cytochrome P450; Region: p450; cl12078 410289010412 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 410289010413 anti sigma factor interaction site; other site 410289010414 regulatory phosphorylation site [posttranslational modification]; other site 410289010415 Uncharacterized conserved protein [Function unknown]; Region: COG1610 410289010416 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 410289010417 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 410289010418 MoxR-like ATPases [General function prediction only]; Region: COG0714 410289010419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289010420 Walker A motif; other site 410289010421 ATP binding site [chemical binding]; other site 410289010422 Walker B motif; other site 410289010423 arginine finger; other site 410289010424 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 410289010425 Protein of unknown function DUF58; Region: DUF58; pfam01882 410289010426 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 410289010427 Predicted membrane protein/domain [Function unknown]; Region: COG1714 410289010428 glycerol kinase; Provisional; Region: glpK; PRK00047 410289010429 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 410289010430 nucleotide binding site [chemical binding]; other site 410289010431 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 410289010432 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 410289010433 Methyltransferase domain; Region: Methyltransf_23; pfam13489 410289010434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289010435 S-adenosylmethionine binding site [chemical binding]; other site 410289010436 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 410289010437 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 410289010438 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 410289010439 catalytic residue [active] 410289010440 Uncharacterized conserved protein [Function unknown]; Region: COG4301 410289010441 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 410289010442 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 410289010443 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 410289010444 putative active site [active] 410289010445 putative dimer interface [polypeptide binding]; other site 410289010446 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 410289010447 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 410289010448 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 410289010449 PknH-like extracellular domain; Region: PknH_C; pfam14032 410289010450 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 410289010451 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 410289010452 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 410289010453 aspartate kinase; Reviewed; Region: PRK06635 410289010454 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 410289010455 putative nucleotide binding site [chemical binding]; other site 410289010456 putative catalytic residues [active] 410289010457 putative Mg ion binding site [ion binding]; other site 410289010458 putative aspartate binding site [chemical binding]; other site 410289010459 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 410289010460 putative allosteric regulatory site; other site 410289010461 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 410289010462 putative allosteric regulatory residue; other site 410289010463 2-isopropylmalate synthase; Validated; Region: PRK03739 410289010464 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 410289010465 active site 410289010466 catalytic residues [active] 410289010467 metal binding site [ion binding]; metal-binding site 410289010468 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 410289010469 S-RD13, 684 bp. Region of Difference S-RD13, repeated region in leuA composed of tandem repeat of 57bp (tcgcgagcccggcgcagccgggcgaagcgggtcggcacgcatcggaccccgtgacga ) . 12 copies have been found in Mycobacterium bovis BCG Pasteur (position 4128585..4129268, 684bp) compared to 2 copies in Mycobacterium tuberculosis strain H37Rv (position 4155469..4155582, 114bp) and 5 copies in Mycobacterium bovis AF2122/97 (position 4092817..4093101, 285bp) 410289010470 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 410289010471 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 410289010472 active site 410289010473 catalytic site [active] 410289010474 substrate binding site [chemical binding]; other site 410289010475 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 410289010476 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 410289010477 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 410289010478 catalytic triad [active] 410289010479 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 410289010480 putative active site [active] 410289010481 recombination protein RecR; Reviewed; Region: recR; PRK00076 410289010482 RecR protein; Region: RecR; pfam02132 410289010483 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 410289010484 putative active site [active] 410289010485 putative metal-binding site [ion binding]; other site 410289010486 tetramer interface [polypeptide binding]; other site 410289010487 hypothetical protein; Validated; Region: PRK00153 410289010488 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 410289010489 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 410289010490 active site 410289010491 metal binding site [ion binding]; metal-binding site 410289010492 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 410289010493 hydrophobic ligand binding site; other site 410289010494 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 410289010495 FAD binding domain; Region: FAD_binding_4; pfam01565 410289010496 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 410289010497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289010498 S-adenosylmethionine binding site [chemical binding]; other site 410289010499 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 410289010500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289010501 Walker A motif; other site 410289010502 ATP binding site [chemical binding]; other site 410289010503 Walker B motif; other site 410289010504 arginine finger; other site 410289010505 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 410289010506 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 410289010507 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 410289010508 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 410289010509 catalytic residue [active] 410289010510 Cutinase; Region: Cutinase; pfam01083 410289010511 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 410289010512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289010513 NAD(P) binding site [chemical binding]; other site 410289010514 active site 410289010515 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 410289010516 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 410289010517 putative NAD(P) binding site [chemical binding]; other site 410289010518 catalytic Zn binding site [ion binding]; other site 410289010519 Uncharacterized conserved protein [Function unknown]; Region: COG3349 410289010520 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 410289010521 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 410289010522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 410289010523 putative substrate translocation pore; other site 410289010524 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 410289010525 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 410289010526 ligand binding site [chemical binding]; other site 410289010527 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 410289010528 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 410289010529 active site 410289010530 nucleophile elbow; other site 410289010531 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 410289010532 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 410289010533 FeS/SAM binding site; other site 410289010534 Methyltransferase domain; Region: Methyltransf_31; pfam13847 410289010535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289010536 S-adenosylmethionine binding site [chemical binding]; other site 410289010537 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 410289010538 nucleotide binding site [chemical binding]; other site 410289010539 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 410289010540 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 410289010541 active site 410289010542 DNA binding site [nucleotide binding] 410289010543 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 410289010544 DNA binding site [nucleotide binding] 410289010545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 410289010546 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 410289010547 nudix motif; other site 410289010548 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 410289010549 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 410289010550 Uncharacterized conserved protein [Function unknown]; Region: COG1839 410289010551 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 410289010552 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 410289010553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 410289010554 Uncharacterized conserved protein [Function unknown]; Region: COG2966 410289010555 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 410289010556 Uncharacterized conserved protein [Function unknown]; Region: COG3610 410289010557 N-RD25, 1166 bp. Region of Difference N-RD25, deleted region in Mycobacterium bovis BCG Pasteur (position 4163162..4163163) and Mycobacterium bovis AF2122/97 (position 4127054..4127055) compared to Mycobacterium tuberculosis H37Rv2 (position: 4189595..4190760). Removes gene Rv3739c(PPE67) and truncates Rv3738c(PPE66) 410289010558 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 410289010559 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 410289010560 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 410289010561 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 410289010562 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 410289010563 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 410289010564 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 410289010565 Soluble P-type ATPase [General function prediction only]; Region: COG4087 410289010566 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 410289010567 dimerization interface [polypeptide binding]; other site 410289010568 putative DNA binding site [nucleotide binding]; other site 410289010569 putative Zn2+ binding site [ion binding]; other site 410289010570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3651 410289010571 DNA binding domain, excisionase family; Region: excise; TIGR01764 410289010572 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 410289010573 active site 410289010574 Int/Topo IB signature motif; other site 410289010575 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 410289010576 nucleoside/Zn binding site; other site 410289010577 dimer interface [polypeptide binding]; other site 410289010578 catalytic motif [active] 410289010579 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 410289010580 prephenate dehydrogenase; Validated; Region: PRK06545 410289010581 prephenate dehydrogenase; Validated; Region: PRK08507 410289010582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554 410289010583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 410289010584 ABC-ATPase subunit interface; other site 410289010585 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 410289010586 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 410289010587 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 410289010588 Walker A/P-loop; other site 410289010589 ATP binding site [chemical binding]; other site 410289010590 Q-loop/lid; other site 410289010591 ABC transporter signature motif; other site 410289010592 Walker B; other site 410289010593 D-loop; other site 410289010594 H-loop/switch region; other site 410289010595 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 410289010596 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 410289010597 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 410289010598 putative active site [active] 410289010599 putative substrate binding site [chemical binding]; other site 410289010600 ATP binding site [chemical binding]; other site 410289010601 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 410289010602 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 410289010603 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 410289010604 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 410289010605 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 410289010606 dimerization interface [polypeptide binding]; other site 410289010607 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 410289010608 dimer interface [polypeptide binding]; other site 410289010609 phosphorylation site [posttranslational modification] 410289010610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 410289010611 ATP binding site [chemical binding]; other site 410289010612 Mg2+ binding site [ion binding]; other site 410289010613 G-X-G motif; other site 410289010614 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 410289010615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 410289010616 active site 410289010617 phosphorylation site [posttranslational modification] 410289010618 intermolecular recognition site; other site 410289010619 dimerization interface [polypeptide binding]; other site 410289010620 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 410289010621 DNA binding site [nucleotide binding] 410289010622 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 410289010623 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 410289010624 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 410289010625 SnoaL-like domain; Region: SnoaL_2; pfam12680 410289010626 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 410289010627 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 410289010628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 410289010629 homodimer interface [polypeptide binding]; other site 410289010630 catalytic residue [active] 410289010631 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 410289010632 TIGR03086 family protein; Region: TIGR03086 410289010633 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 410289010634 enoyl-CoA hydratase; Provisional; Region: PRK06142 410289010635 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 410289010636 substrate binding site [chemical binding]; other site 410289010637 oxyanion hole (OAH) forming residues; other site 410289010638 trimer interface [polypeptide binding]; other site 410289010639 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 410289010640 Beta-lactamase; Region: Beta-lactamase; pfam00144 410289010641 Domain of unknown function (DUF222); Region: DUF222; pfam02720 410289010642 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 410289010643 active site 410289010644 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 410289010645 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 410289010646 NAD(P) binding site [chemical binding]; other site 410289010647 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 410289010648 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 410289010649 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 410289010650 catalytic residue [active] 410289010651 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 410289010652 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 410289010653 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 410289010654 Walker A/P-loop; other site 410289010655 ATP binding site [chemical binding]; other site 410289010656 Q-loop/lid; other site 410289010657 ABC transporter signature motif; other site 410289010658 Walker B; other site 410289010659 D-loop; other site 410289010660 H-loop/switch region; other site 410289010661 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 410289010662 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 410289010663 active site 410289010664 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 410289010665 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 410289010666 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 410289010667 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 410289010668 NAD binding site [chemical binding]; other site 410289010669 substrate binding site [chemical binding]; other site 410289010670 active site 410289010671 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 410289010672 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 410289010673 active site 410289010674 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 410289010675 Peptidase family M23; Region: Peptidase_M23; pfam01551 410289010676 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 410289010677 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 410289010678 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 410289010679 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 410289010680 Predicted membrane protein [Function unknown]; Region: COG2246 410289010681 GtrA-like protein; Region: GtrA; pfam04138 410289010682 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 410289010683 FAD binding domain; Region: FAD_binding_4; pfam01565 410289010684 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 410289010685 short chain dehydrogenase; Provisional; Region: PRK07904 410289010686 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 410289010687 NAD(P) binding site [chemical binding]; other site 410289010688 active site 410289010689 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 410289010690 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 410289010691 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 410289010692 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 410289010693 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 410289010694 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 410289010695 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 410289010696 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 410289010697 FAD binding site [chemical binding]; other site 410289010698 substrate binding site [chemical binding]; other site 410289010699 catalytic residues [active] 410289010700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 410289010701 Transposase; Region: DDE_Tnp_ISL3; pfam01610 410289010702 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 410289010703 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 410289010704 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 410289010705 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289010706 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289010707 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 410289010708 active site 410289010709 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 410289010710 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 410289010711 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289010712 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 410289010713 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 410289010714 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 410289010715 acyl-activating enzyme (AAE) consensus motif; other site 410289010716 active site 410289010717 Cutinase; Region: Cutinase; pfam01083 410289010718 Predicted esterase [General function prediction only]; Region: COG0627 410289010719 Putative esterase; Region: Esterase; pfam00756 410289010720 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 410289010721 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 410289010722 active site 410289010723 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 410289010724 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 410289010725 active site 410289010726 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 410289010727 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 410289010728 UDP-galactopyranose mutase; Region: GLF; pfam03275 410289010729 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 410289010730 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 410289010731 amidase catalytic site [active] 410289010732 Zn binding residues [ion binding]; other site 410289010733 substrate binding site [chemical binding]; other site 410289010734 LGFP repeat; Region: LGFP; pfam08310 410289010735 PE family; Region: PE; pfam00934 410289010736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 410289010737 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 410289010738 active site 410289010739 motif I; other site 410289010740 motif II; other site 410289010741 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 410289010742 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 410289010743 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 410289010744 putative acyl-acceptor binding pocket; other site 410289010745 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 410289010746 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 410289010747 putative acyl-acceptor binding pocket; other site 410289010748 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 410289010749 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 410289010750 putative acyl-acceptor binding pocket; other site 410289010751 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 410289010752 Phosphotransferase enzyme family; Region: APH; pfam01636 410289010753 active site 410289010754 ATP binding site [chemical binding]; other site 410289010755 antibiotic binding site [chemical binding]; other site 410289010756 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 410289010757 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 410289010758 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 410289010759 iron-sulfur cluster [ion binding]; other site 410289010760 [2Fe-2S] cluster binding site [ion binding]; other site 410289010761 Condensation domain; Region: Condensation; pfam00668 410289010762 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 410289010763 PE-PPE domain; Region: PE-PPE; pfam08237 410289010764 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 410289010765 Condensation domain; Region: Condensation; pfam00668 410289010766 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 410289010767 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 410289010768 active site 410289010769 Acyl transferase domain; Region: Acyl_transf_1; cl08282 410289010770 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 410289010771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 410289010772 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 410289010773 Enoylreductase; Region: PKS_ER; smart00829 410289010774 NAD(P) binding site [chemical binding]; other site 410289010775 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 410289010776 KR domain; Region: KR; pfam08659 410289010777 putative NADP binding site [chemical binding]; other site 410289010778 active site 410289010779 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 410289010780 acyl-CoA synthetase; Validated; Region: PRK05850 410289010781 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 410289010782 acyl-activating enzyme (AAE) consensus motif; other site 410289010783 active site 410289010784 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 410289010785 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 410289010786 Probable transposase; Region: OrfB_IS605; pfam01385 410289010787 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 410289010788 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 410289010789 catalytic residues [active] 410289010790 catalytic nucleophile [active] 410289010791 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 410289010792 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 410289010793 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 410289010794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289010795 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 410289010796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 410289010797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 410289010798 Cupin domain; Region: Cupin_2; cl17218 410289010799 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 410289010800 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 410289010801 seryl-tRNA synthetase; Provisional; Region: PRK05431 410289010802 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 410289010803 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 410289010804 dimer interface [polypeptide binding]; other site 410289010805 active site 410289010806 motif 1; other site 410289010807 motif 2; other site 410289010808 motif 3; other site 410289010809 Septum formation; Region: Septum_form; pfam13845 410289010810 Septum formation; Region: Septum_form; pfam13845 410289010811 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 410289010812 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 410289010813 catalytic core [active] 410289010814 prephenate dehydratase; Provisional; Region: PRK11898 410289010815 Prephenate dehydratase; Region: PDT; pfam00800 410289010816 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 410289010817 putative L-Phe binding site [chemical binding]; other site 410289010818 Transcriptional regulator [Transcription]; Region: LytR; COG1316 410289010819 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 410289010820 Ferritin-like domain; Region: Ferritin; pfam00210 410289010821 ferroxidase diiron center [ion binding]; other site 410289010822 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 410289010823 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 410289010824 putative active site [active] 410289010825 catalytic site [active] 410289010826 putative metal binding site [ion binding]; other site 410289010827 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 410289010828 Transposase; Region: DEDD_Tnp_IS110; pfam01548 410289010829 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 410289010830 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 410289010831 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 410289010832 Predicted membrane protein [Function unknown]; Region: COG2119 410289010833 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 410289010834 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 410289010835 Fimbrial protein; Region: Fimbrial; cl01416 410289010836 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 410289010837 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 410289010838 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 410289010839 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 410289010840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 410289010841 hypothetical protein; Provisional; Region: PRK07945 410289010842 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 410289010843 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 410289010844 active site 410289010845 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 410289010846 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 410289010847 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 410289010848 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 410289010849 active site 410289010850 dimer interface [polypeptide binding]; other site 410289010851 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 410289010852 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 410289010853 active site 410289010854 FMN binding site [chemical binding]; other site 410289010855 substrate binding site [chemical binding]; other site 410289010856 3Fe-4S cluster binding site [ion binding]; other site 410289010857 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 410289010858 domain interface; other site 410289010859 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 410289010860 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 410289010861 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 410289010862 EspG family; Region: ESX-1_EspG; pfam14011 410289010863 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 410289010864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289010865 Walker A motif; other site 410289010866 ATP binding site [chemical binding]; other site 410289010867 Walker B motif; other site 410289010868 arginine finger; other site 410289010869 Protein of unknown function (DUF690); Region: DUF690; pfam05108 410289010870 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 410289010871 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 410289010872 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 410289010873 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 410289010874 RD1, 9457 bp. Region of Difference RD1, deleted region in Mycobacterium bovis BCG Pasteur (position 4322714..4322715) compared to Mycobacterium tuberculosis H37Rv2 (position: 4350266-4359722) and Mycobacterium bovis AF2122/97 (position 4286586..4296087). Removes genes Rv3872-Rv3879c 410289010875 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 410289010876 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 410289010877 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 410289010878 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 410289010879 active site 410289010880 catalytic residues [active] 410289010881 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 410289010882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 410289010883 Walker A motif; other site 410289010884 ATP binding site [chemical binding]; other site 410289010885 Walker B motif; other site 410289010886 arginine finger; other site 410289010887 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 410289010888 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 410289010889 catalytic residues [active] 410289010890 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 410289010891 active site 410289010892 catalytic residues [active] 410289010893 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 410289010894 RDpan, 2405 bp. Region of Difference RDpan, deleted region in Mycobacterium bovis AF2122/97 (position 4307384..4307385) compared to Mycobacterium tuberculosis H37Rv2 (position: 4371020..4373425, 2406bp) and Mycobacterium bovis BCG Pasteur (position 4334012..4336416, 2405bp). Removes genes Rv3888c (BCG_3943c-BCG_3944c), and truncates Rv3887c and Rv3889c (BCG_3942c and BCG_3945c). One base deletion in Mycobacterium bovis BCG Pasteur compared to Mycobacterium tuberculosis strain H37Rv2 (position: 4372564) splits Rv3888c in two genes, BCG_3944c and BCG_3943c 410289010895 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 410289010896 EspG family; Region: ESX-1_EspG; pfam14011 410289010897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 410289010898 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 410289010899 PPE family; Region: PPE; pfam00823 410289010900 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 410289010901 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 410289010902 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 410289010903 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 410289010904 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 410289010905 Protein of unknown function (DUF690); Region: DUF690; pfam05108 410289010906 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 410289010907 catalytic residue [active] 410289010908 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 410289010909 Proteins of 100 residues with WXG; Region: WXG100; cl02005 410289010910 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 410289010911 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 410289010912 active site 410289010913 NTP binding site [chemical binding]; other site 410289010914 metal binding triad [ion binding]; metal-binding site 410289010915 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 410289010916 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 410289010917 Zn2+ binding site [ion binding]; other site 410289010918 Mg2+ binding site [ion binding]; other site 410289010919 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 410289010920 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 410289010921 active site 410289010922 Ap6A binding site [chemical binding]; other site 410289010923 nudix motif; other site 410289010924 metal binding site [ion binding]; metal-binding site 410289010925 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 410289010926 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 410289010927 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 410289010928 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 410289010929 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 410289010930 DNA binding residues [nucleotide binding] 410289010931 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 410289010932 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 410289010933 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 410289010934 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 410289010935 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 410289010936 catalytic residues [active] 410289010937 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 410289010938 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 410289010939 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 410289010940 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 410289010941 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 410289010942 active site 410289010943 metal binding site [ion binding]; metal-binding site 410289010944 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 410289010945 ParB-like nuclease domain; Region: ParB; smart00470 410289010946 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 410289010947 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 410289010948 P-loop; other site 410289010949 Magnesium ion binding site [ion binding]; other site 410289010950 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 410289010951 Magnesium ion binding site [ion binding]; other site 410289010952 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 410289010953 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 410289010954 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 410289010955 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 410289010956 G-X-X-G motif; other site 410289010957 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 410289010958 RxxxH motif; other site 410289010959 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 410289010960 Uncharacterized conserved protein [Function unknown]; Region: COG0759 410289010961 ribonuclease P; Reviewed; Region: rnpA; PRK00588 410289010962 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399