-- dump date 20140619_151607 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_002643051.1 224988384 7561459 1..1524 1 NC_012207.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1524 dnaA 7561459 dnaA Mycobacterium bovis BCG str. Tokyo 172 chromosomal replication initiation protein YP_002643051.1 1 D 561275 CDS YP_002643052.1 224988385 7561499 2052..3260 1 NC_012207.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 3260 dnaN 7561499 dnaN Mycobacterium bovis BCG str. Tokyo 172 DNA polymerase III subunit beta YP_002643052.1 2052 D 561275 CDS YP_002643053.1 224988386 7561507 3280..4437 1 NC_012207.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 4437 recF 7561507 recF Mycobacterium bovis BCG str. Tokyo 172 recombination protein F YP_002643053.1 3280 D 561275 CDS YP_002643054.1 224988387 7561558 4434..4997 1 NC_012207.1 Differs from Mb0004 by 1aa, S16L in BCG Pasteur and BCG Tokyo; hypothetical protein 4997 7561558 JTY_0004 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643054.1 4434 D 561275 CDS YP_002643055.1 224988388 7560958 5123..7267 1 NC_012207.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 7267 gyrB 7560958 gyrB Mycobacterium bovis BCG str. Tokyo 172 DNA gyrase subunit B YP_002643055.1 5123 D 561275 CDS YP_002643056.1 224988389 7563292 7302..9818 1 NC_012207.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 9818 gyrA 7563292 gyrA Mycobacterium bovis BCG str. Tokyo 172 DNA gyrase subunit A YP_002643056.1 7302 D 561275 CDS YP_002643057.1 224988390 7563291 9914..10828 1 NC_012207.1 Differs from Mb0007 by 1aa, I272V in BCG Pasteur and BCG Tokyo; hypothetical protein 10828 7563291 JTY_0007 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643057.1 9914 D 561275 CDS YP_002643058.1 224988391 7563955 complement(11874..12311) 1 NC_012207.1 Differs from Rv0008c by 1aa, P145S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 12311 7563955 JTY_0008 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643058.1 11874 R 561275 CDS YP_002643059.1 224988392 7560960 12468..13016 1 NC_012207.1 iron-regulated peptidyl-prolyl cis-trans isomerase A 13016 ppiA 7560960 ppiA Mycobacterium bovis BCG str. Tokyo 172 iron-regulated peptidyl-prolyl cis-trans isomerase A YP_002643059.1 12468 D 561275 CDS YP_002643060.1 224988393 7560806 complement(13222..13557) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur and BCG Tokyo, and Mycobacterium bovis, a single base deletion (g-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (111 aa versus 141 aa); hypothetical protein 13557 7560806 JTY_0010 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643060.1 13222 R 561275 CDS YP_002643061.1 224988394 7560961 complement(13713..13994) 1 NC_012207.1 integral membrane protein involved in inhibition of the Z-ring formation; septation inhibitor protein 13994 7560961 JTY_0011 Mycobacterium bovis BCG str. Tokyo 172 septation inhibitor protein YP_002643061.1 13713 R 561275 CDS YP_002643062.1 224988395 7560962 14088..14876 1 NC_012207.1 Differs from Rv0012 by 2aa, E105K, R233C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 14876 7560962 JTY_0012 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643062.1 14088 D 561275 CDS YP_002643063.1 224988396 7560963 14913..15611 1 NC_012207.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 15611 trpG 7560963 trpG Mycobacterium bovis BCG str. Tokyo 172 para-aminobenzoate synthase component II YP_002643063.1 14913 D 561275 CDS YP_002643064.1 224988397 7561633 complement(15589..17469) 1 NC_012207.1 transmembrane serine/threonine-protein kinase B 17469 pknB 7561633 pknB Mycobacterium bovis BCG str. Tokyo 172 transmembrane serine/threonine-protein kinase B YP_002643064.1 15589 R 561275 CDS YP_002643065.1 224988398 7562429 complement(17466..18761) 1 NC_012207.1 transmembrane serine/threonine-protein kinase A 18761 pknA 7562429 pknA Mycobacterium bovis BCG str. Tokyo 172 transmembrane serine/threonine-protein kinase A YP_002643065.1 17466 R 561275 CDS YP_002643066.1 224988399 7562428 complement(18758..20233) 1 NC_012207.1 penicillin-binding protein 20233 pbpA 7562428 pbpA Mycobacterium bovis BCG str. Tokyo 172 penicillin-binding protein YP_002643066.1 18758 R 561275 CDS YP_002643067.1 224988400 7562518 complement(20230..21639) 1 NC_012207.1 cell division protein 21639 rodA 7562518 rodA Mycobacterium bovis BCG str. Tokyo 172 cell division protein YP_002643067.1 20230 R 561275 CDS YP_002643068.1 224988401 7561594 complement(21636..23180) 1 NC_012207.1 Differs from Rv0018c by 3aa, L3R, A455S, S463P in Mcobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; serine/threonine phosphatase 23180 ppp 7561594 ppp Mycobacterium bovis BCG str. Tokyo 172 serine/threonine phosphatase YP_002643068.1 21636 R 561275 CDS YP_002643069.1 224988402 7560811 complement(23269..23736) 1 NC_012207.1 hypothetical protein 23736 7560811 JTY_0019 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643069.1 23269 R 561275 CDS YP_002643070.1 224988403 7560964 complement(23860..25425) 1 NC_012207.1 Differs from Mb0020c by 2aa, G47R, Y250H, and from Rv0020c by 3aa, G222D, C298Y, Q378R, and deletion of 6aa (EQRGYP) at position 246 in BCG Pasteur and BCG Tokyo; hypothetical protein 25425 TB39.8 7560964 TB39.8 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643070.1 23860 R 561275 CDS YP_002643071.1 224988404 7562818 complement(25894..26862) 1 NC_012207.1 Differs from Rv0021c by 1aa, P277A in Mcobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 26862 7562818 JTY_0021 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643071.1 25894 R 561275 CDS YP_002643072.1 224988405 7560965 complement(27004..27423) 1 NC_012207.1 transcriptional regulator whiB-like 27423 whiB5 7560965 whiB5 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulator whiB-like YP_002643072.1 27004 R 561275 CDS YP_002643073.1 224988406 7561693 27576..28346 1 NC_012207.1 transcriptional regulatory protein 28346 7561693 JTY_0023 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643073.1 27576 D 561275 CDS YP_002643074.1 224988407 7560966 28343..29176 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, and other mycobacteria, Rv0024 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (C-*) splits Rv0024 into 2 parts; hypothetical protein P60-related protein 29176 7560966 JTY_0024 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein P60-related protein YP_002643074.1 28343 D 561275 CDS YP_002643075.1 224988408 7560968 29225..29587 1 NC_012207.1 Differs from Rv0025 by 1aa, L73P in Mcobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 29587 7560968 JTY_0026 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643075.1 29225 D 561275 CDS YP_002643076.1 224988409 7560969 29702..31135 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 4 bp insertion (*-ATCG) leads to a longer protein with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (477 aa versus 448 aa). Differs from Rv0026 by 1aa, P93Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 31135 7560969 JTY_0027 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643076.1 29702 D 561275 CDS YP_002643077.1 224988410 7560970 31173..31490 1 NC_012207.1 hypothetical protein 31490 7560970 JTY_0028 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643077.1 31173 D 561275 CDS YP_002643078.1 224988411 7560971 31498..31803 1 NC_012207.1 hypothetical protein 31803 7560971 JTY_0029 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643078.1 31498 D 561275 CDS YP_002643079.1 224988412 7560972 32041..33138 1 NC_012207.1 Differs from Rv0029 by 1aa, N190H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 33138 7560972 JTY_0030 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643079.1 32041 D 561275 CDS YP_002643080.1 224988413 7560973 33208..33537 1 NC_012207.1 hypothetical protein 33537 7560973 JTY_0031 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643080.1 33208 D 561275 CDS YP_002643081.1 224988414 7560974 33566..33778 1 NC_012207.1 remnant of a transposase 33778 7560974 JTY_0032 Mycobacterium bovis BCG str. Tokyo 172 remnant of a transposase YP_002643081.1 33566 D 561275 CDS YP_002643082.1 224988415 7560975 34279..36594 1 NC_012207.1 8-amino-7-oxononanoate synthase 36594 bioF2 7560975 bioF2 Mycobacterium bovis BCG str. Tokyo 172 8-amino-7-oxononanoate synthase YP_002643082.1 34279 D 561275 CDS YP_002643083.1 224988416 7562070 36591..36854 1 NC_012207.1 acyl carrier protein 36854 acpA 7562070 acpA Mycobacterium bovis BCG str. Tokyo 172 acyl carrier protein YP_002643083.1 36591 D 561275 CDS YP_002643084.1 224988417 7563931 36851..37246 1 NC_012207.1 hypothetical protein 37246 7563931 JTY_0035 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643084.1 36851 D 561275 CDS YP_002643085.1 224988418 7560976 37243..38931 1 NC_012207.1 fatty-acid-CoA synthetase, fatty-acid-CoA synthase; fatty-acid-CoA ligase 38931 fadD34 7560976 fadD34 Mycobacterium bovis BCG str. Tokyo 172 fatty-acid-CoA ligase YP_002643085.1 37243 D 561275 CDS YP_002643086.1 224988419 7563350 complement(39132..39812) 1 NC_012207.1 Differs from Mb0037c and Rv0036c by 1aa in BCG Pasteur and BCG Tokyo, L186P in BCG Pasteur, and at C-terminal end due to frameshift resulting from 1 bp deletion at position equivalent to Mycobacterium tuberculosis H37Rv, 39228-39228, after codon 202 in BCG Pasteur and Tokyo.; hypothetical protein 39812 7563350 JTY_0037 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643086.1 39132 R 561275 CDS YP_002643087.1 224988420 7560977 complement(39860..41185) 1 NC_012207.1 integral membrane protein 41185 7560977 JTY_0038 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002643087.1 39860 R 561275 CDS YP_002643088.1 224988421 7560978 41287..41895 1 NC_012207.1 hypothetical protein 41895 7560978 JTY_0039 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643088.1 41287 D 561275 CDS YP_002643089.1 224988422 7560979 complement(41987..42334) 1 NC_012207.1 Differs from Rv0039c by 1aa, F24C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 42334 7560979 JTY_0040 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643089.1 41987 R 561275 CDS YP_002643090.1 224988423 7560980 complement(42416..43348) 1 NC_012207.1 proline rich 28 kDa antigen; proline rich protein 43348 mtc28 7560980 mtc28 Mycobacterium bovis BCG str. Tokyo 172 proline rich protein YP_002643090.1 42416 R 561275 CDS YP_002643091.1 224988424 7563566 43545..46454 1 NC_012207.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 46454 leuS 7563566 leuS Mycobacterium bovis BCG str. Tokyo 172 leucyl-tRNA synthetase YP_002643091.1 43545 D 561275 CDS YP_002643092.1 224988425 7562817 complement(46564..47190) 1 NC_012207.1 MarR-FAMILY; transcriptional regulatory protein 47190 7562817 JTY_0043 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643092.1 46564 R 561275 CDS YP_002643093.1 224988426 7560981 complement(47349..48083) 1 NC_012207.1 probably GntR-family; transcriptional regulatory protein 48083 7560981 JTY_0044 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643093.1 47349 R 561275 CDS YP_002643094.1 224988427 7560982 complement(48216..49010) 1 NC_012207.1 oxidoreductase 49010 7560982 JTY_0045 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002643094.1 48216 R 561275 CDS YP_002643095.1 224988428 7560983 complement(49026..49922) 1 NC_012207.1 hydrolase 49922 7560983 JTY_0046 Mycobacterium bovis BCG str. Tokyo 172 hydrolase YP_002643095.1 49026 R 561275 CDS YP_002643096.1 224988429 7560984 complement(50004..51107) 1 NC_012207.1 Differs from Mb0047c by 1aa, T120I, and from Rv0046c by 2aa, T120I, G190R; myo-inositol-1-phosphate synthase 51107 ino1 7560984 ino1 Mycobacterium bovis BCG str. Tokyo 172 myo-inositol-1-phosphate synthase YP_002643096.1 50004 R 561275 CDS YP_002643097.1 224988430 7562792 complement(51168..51710) 1 NC_012207.1 hypothetical protein 51710 7562792 JTY_0048 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643097.1 51168 R 561275 CDS YP_002643098.1 224988431 7560985 complement(51811..52680) 1 NC_012207.1 Differs from Rv0048c by 1aa, A250V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 52680 7560985 JTY_0049 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643098.1 51811 R 561275 CDS YP_002643099.1 224988432 7560986 52814..53227 1 NC_012207.1 hypothetical protein 53227 7560986 JTY_0050 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643099.1 52814 D 561275 CDS YP_002643100.1 224988433 7560987 53646..55691 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur and BCG Tokyo, insertion of 3 codons after position 632 leads to a slightly longer product compared to its homologs in Mycobacterium tuberculosis strain H37Rv (681 aa versus 678 aa) and Mycobacterium bovis AF2122/97 (681 aa versus 680 aa). In addition, differs from Rv0050 by 1aa, L6P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; bifunctional penicillin-binding protein 1A/1B 55691 ponA1 7560987 ponA1 Mycobacterium bovis BCG str. Tokyo 172 bifunctional penicillin-binding protein 1A/1B YP_002643100.1 53646 D 561275 CDS YP_002643101.1 224988434 7562140 55688..57370 1 NC_012207.1 transmembrane protein 57370 7562140 JTY_0052 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643101.1 55688 D 561275 CDS YP_002643102.1 224988435 7560988 57402..57965 1 NC_012207.1 hypothetical protein 57965 7560988 JTY_0053 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643102.1 57402 D 561275 CDS YP_002643103.1 224988436 7560989 58184..58474 1 NC_012207.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 58474 rpsF 7560989 rpsF Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S6 YP_002643103.1 58184 D 561275 CDS YP_002643104.1 224988437 7560733 58578..59072 1 NC_012207.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 59072 ssb 7560733 ssb Mycobacterium bovis BCG str. Tokyo 172 single-stranded DNA-binding protein YP_002643104.1 58578 D 561275 CDS YP_002643105.1 224988438 7561807 59114..59368 1 NC_012207.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 59368 rpsR 7561807 rpsR Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S18 YP_002643105.1 59114 D 561275 CDS YP_002643106.1 224988439 7560746 59401..59859 1 NC_012207.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 59859 rplI 7560746 rplI Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L9 YP_002643106.1 59401 D 561275 CDS YP_002643107.1 224988440 7561609 59888..60409 1 NC_012207.1 hypothetical protein 60409 7561609 JTY_0058 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643107.1 59888 D 561275 CDS YP_002643108.1 224988441 7560990 60388..63012 1 NC_012207.1 unwinds double stranded DNA; these Mycobacterial enzymes appear to contain inteins; replicative DNA helicase 63012 dnaB 7560990 dnaB Mycobacterium bovis BCG str. Tokyo 172 replicative DNA helicase YP_002643108.1 60388 D 561275 CDS YP_002643109.1 224988442 7561500 63192..63884 1 NC_012207.1 hypothetical protein 63884 7561500 JTY_0060 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643109.1 63192 D 561275 CDS YP_002643110.1 224988443 7560991 63901..64959 1 NC_012207.1 hypothetical protein 64959 7560991 JTY_0061 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643110.1 63901 D 561275 CDS YP_002643131.1 224988444 7560992 64983..65408 1 NC_012207.1 hypothetical protein 65408 7560992 JTY_0062 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643131.1 64983 D 561275 CDS YP_002643132.1 224988445 7560993 65544..66686 1 NC_012207.1 Differs from Mb0063 by 1aa, A72D, and from Rv0062 by 2aa, A72D, V106I in BCG Pasteur and BCG Tokyo; endoglucanase; cellulase 66686 celA1 7560993 celA1 Mycobacterium bovis BCG str. Tokyo 172 cellulase YP_002643132.1 65544 D 561275 CDS YP_002643133.1 224988446 7562092 66915..68354 1 NC_012207.1 oxidoreductase 68354 7562092 JTY_0064 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002643133.1 66915 D 561275 CDS YP_002643134.1 224988447 7560994 68612..71551 1 NC_012207.1 Differs from Mb0065 by 1aa, T435I, and from Rv0064 by 4aa, T435I, D457G, F550V, P906R in BCG Pasteur and BCG Tokyo; hypothetical protein 71551 7560994 JTY_0065 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643134.1 68612 D 561275 CDS YP_002643135.1 224988448 7560995 71618..71857 1 NC_012207.1 Differs from Rv0064A by 1aa, V48A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; antitoxin 71857 7560995 JTY_0066 Mycobacterium bovis BCG str. Tokyo 172 antitoxin YP_002643135.1 71618 D 561275 CDS YP_002643136.1 224988449 7560996 71850..72251 1 NC_012207.1 hypothetical protein 72251 7560996 JTY_0067 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643136.1 71850 D 561275 CDS YP_002643137.1 224988450 7560997 complement(72303..74540) 1 NC_012207.1 Differs from Rv0066c by 1aa, N117K in in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; isocitrate dehydrogenase 74540 icd2 7560997 icd2 Mycobacterium bovis BCG str. Tokyo 172 isocitrate dehydrogenase YP_002643137.1 72303 R 561275 CDS YP_002643138.1 224988451 7563340 complement(74658..75227) 1 NC_012207.1 possibly TetR-family; transcriptional regulatory protein 75227 7563340 JTY_0069 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643138.1 74658 R 561275 CDS YP_002643139.1 224988452 7560998 75330..76241 1 NC_012207.1 Differs from Rv0068 by 1aa, L214V in Mycobacterium bovis, Mycobacterium tuberculosis CDC1551, BCG Pasteur, and BCG Tokyo.; short chain dehydrogenase 76241 7560998 JTY_0070 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002643139.1 75330 D 561275 CDS YP_002643140.1 224988453 7560999 complement(76266..77651) 1 NC_012207.1 L-serine dehydratase 77651 sdaA 7560999 sdaA Mycobacterium bovis BCG str. Tokyo 172 L-serine dehydratase YP_002643140.1 76266 R 561275 CDS YP_002643141.1 224988454 7560760 complement(77648..78925) 1 NC_012207.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 78925 glyA 7560760 glyA Mycobacterium bovis BCG str. Tokyo 172 serine hydroxymethyltransferase YP_002643141.1 77648 R 561275 CDS YP_002643142.1 224988455 7561953 79515..80267 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 45 bp insertion (5 copies of VDP repeat) leads to longer products compared to its homologs in Mycobacterium tuberculosis strain H37Rv (250 aa versus 235 aa) and Mycobacterium bovis (250 aa versus 238 aa); maturase 80267 7561953 JTY_0073 Mycobacterium bovis BCG str. Tokyo 172 maturase YP_002643142.1 79515 D 561275 CDS YP_002643143.1 224988456 7561000 80698..81747 1 NC_012207.1 glutamine-transport transmembrane protein ABC transporter 81747 7561000 JTY_0074 Mycobacterium bovis BCG str. Tokyo 172 glutamine-transport transmembrane protein ABC transporter YP_002643143.1 80698 D 561275 CDS YP_002643144.1 224988457 7561001 81750..82742 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv0073 exists as a single gene as in Mycobacterium bovis BCG Pasteur and BCG Tokyo. In Mycobacterium bovis, a frameshift due to a single base deletion (A-*) splits Rv0073 into 2 parts, Mb0074 and Mb0075; glutamine-transport ATP-binding protein ABC transporter 82742 7561001 JTY_0075 Mycobacterium bovis BCG str. Tokyo 172 glutamine-transport ATP-binding protein ABC transporter YP_002643144.1 81750 D 561275 CDS YP_002643145.1 224988458 7561002 82822..84057 1 NC_012207.1 hypothetical protein 84057 7561002 JTY_0076 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643145.1 82822 D 561275 CDS YP_002643146.1 224988459 7561003 84070..85242 1 NC_012207.1 Differs from Rv0075 and Mb0077 by 1aa, G326D in BCG Pasteur and BCG Tokyo; aminotransferase 85242 7561003 JTY_0077 Mycobacterium bovis BCG str. Tokyo 172 aminotransferase YP_002643146.1 84070 D 561275 CDS YP_002643147.1 224988460 7561004 complement(85257..85646) 1 NC_012207.1 hypothetical protein 85646 7561004 JTY_0078 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643147.1 85257 R 561275 CDS YP_002643148.1 224988461 7561005 complement(85710..86540) 1 NC_012207.1 oxidoreductase 86540 7561005 JTY_0079 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002643148.1 85710 R 561275 CDS YP_002643149.1 224988462 7561006 86602..87207 1 NC_012207.1 Differs from Rv0078 by 1aa, V113I in BCG Pasteur and BCG Tokyo; transcriptional regulatory protein 87207 7561006 JTY_0080 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643149.1 86602 D 561275 CDS YP_002643150.1 224988463 7561007 complement(87282..87875) 1 NC_012207.1 hypothetical protein 87875 7561007 JTY_0081 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643150.1 87282 R 561275 CDS YP_002643151.1 224988464 7561008 complement(87872..88084) 1 NC_012207.1 hypothetical protein 88084 7561008 JTY_0082 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643151.1 87872 R 561275 CDS YP_002643152.1 224988465 7561009 88278..89099 1 NC_012207.1 hypothetical protein 89099 7561009 JTY_0083 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643152.1 88278 D 561275 CDS YP_002643153.1 224988466 7561010 89096..89554 1 NC_012207.1 Differs from Mb0083 by 1aa, C35R, and from Rv0080 by 2aa, C35R, V60G in BCG Pasteur. Differs from Rv0080 by 1aa, V60G in BCG Tokyo. without qualifier; hypothetical protein 89554 7561010 JTY_0084 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643153.1 89096 D 561275 CDS YP_002643154.1 224988467 7561011 89649..89993 1 NC_012207.1 transcriptional regulatory protein 89993 7561011 JTY_0085 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643154.1 89649 D 561275 CDS YP_002643155.1 224988468 7561012 89998..90477 1 NC_012207.1 Differs from Rv0082 by 1aa, R74Q in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 90477 7561012 JTY_0086 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002643155.1 89998 D 561275 CDS YP_002643156.1 224988469 7561013 90474..92402 1 NC_012207.1 In Mycobacterium bovis, a single base transversion (a-t) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (642 aa versus 640 aa). Differs from Mb0086 by 1aa, A177V in BCG Pasteur and BCG Tokyo.; oxidoreductase 92402 7561013 JTY_0087 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002643156.1 90474 D 561275 CDS YP_002643157.1 224988470 7561014 92402..93352 1 NC_012207.1 formate hydrogenlyase 93352 hycD 7561014 hycD Mycobacterium bovis BCG str. Tokyo 172 formate hydrogenlyase YP_002643157.1 92402 D 561275 CDS YP_002643158.1 224988471 7563335 93363..94025 1 NC_012207.1 hydrogenase 94025 hycP 7563335 hycP Mycobacterium bovis BCG str. Tokyo 172 hydrogenase YP_002643158.1 93363 D 561275 CDS YP_002643159.1 224988472 7563337 94025..95491 1 NC_012207.1 Differs from Rv0086 by 1aa, T118M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrogenase 95491 hycQ 7563337 hycQ Mycobacterium bovis BCG str. Tokyo 172 hydrogenase YP_002643159.1 94025 D 561275 CDS YP_002643160.1 224988473 7563338 95488..96966 1 NC_012207.1 Differs from Rv0087 by 1aa, I230V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; formate hydrogenase 96966 hycE 7563338 hycE Mycobacterium bovis BCG str. Tokyo 172 formate hydrogenase YP_002643160.1 95488 D 561275 CDS YP_002643161.1 224988474 7563336 97001..97675 1 NC_012207.1 hypothetical protein 97675 7563336 JTY_0092 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643161.1 97001 D 561275 CDS YP_002643162.1 224988475 7561015 97832..98425 1 NC_012207.1 methyltransferase/methylase 98425 7561015 JTY_0093 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase/methylase YP_002643162.1 97832 D 561275 CDS YP_002643163.1 224988476 7561016 98554..99324 1 NC_012207.1 hypothetical protein 99324 7561016 JTY_0094 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643163.1 98554 D 561275 CDS YP_002643164.1 224988477 7561017 99758..100525 1 NC_012207.1 bifunctional MTA/SAH nucleosidase 100525 mtn 7561017 mtn Mycobacterium bovis BCG str. Tokyo 172 bifunctional MTA/SAH nucleosidase YP_002643164.1 99758 D 561275 CDS YP_002643165.1 224988478 7563567 100657..102942 1 NC_012207.1 Differs from Rv0092 by 1aa, A3T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cation transporter p-type ATPase A 102942 ctpA 7563567 ctpA Mycobacterium bovis BCG str. Tokyo 172 cation transporter p-type ATPase A YP_002643165.1 100657 D 561275 CDS YP_002643166.1 224988479 7563131 complement(102889..103737) 1 NC_012207.1 Differs from Rv0093c by 1aa, R22C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 103737 7563131 JTY_0097 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643166.1 102889 R 561275 CDS YP_002643167.1 224988480 7561018 complement(103784..104737) 1 NC_012207.1 Differs from Rv0094c by 3aa, D256E, W296R, K315E in BCG Pasteur and BCG Tokyo; hypothetical protein 104737 7561018 JTY_0098 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643167.1 103784 R 561275 CDS YP_002643168.1 224988481 7561019 complement(104508..105290) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv0095c and Rv1588 exist as separate genes in their respective positions. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 73 bp substitution leads to a single combined gene. Differs from Rv0095c by 5aa, E57D, T70S, V85A, V91G, A92Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 105290 7561019 JTY_0099 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643168.1 104508 R 561275 CDS YP_002643169.1 224988482 7561020 105399..106790 1 NC_012207.1 Differs from Rv0096 by 1aa, W182R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PPE family protein 106790 PPE1 7561020 PPE1 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002643169.1 105399 D 561275 CDS YP_002643170.1 224988483 7562144 106809..107678 1 NC_012207.1 oxidoreductase 107678 7562144 JTY_0101 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002643170.1 106809 D 561275 CDS YP_002643171.1 224988484 7561021 107675..108226 1 NC_012207.1 hypothetical protein 108226 7561021 JTY_0102 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643171.1 107675 D 561275 CDS YP_002643172.1 224988485 7561022 108231..109853 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 109853 fadD10 7561022 fadD10 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002643172.1 108231 D 561275 CDS YP_002643173.1 224988486 7562916 109858..110094 1 NC_012207.1 hypothetical protein 110094 7562916 JTY_0104 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643173.1 109858 D 561275 CDS YP_002643174.1 224988487 7561023 110076..117614 1 NC_012207.1 peptide synthetase 117614 nrp 7561023 nrp Mycobacterium bovis BCG str. Tokyo 172 peptide synthetase YP_002643174.1 110076 D 561275 CDS YP_002643175.1 224988488 7562471 117789..119774 1 NC_012207.1 integral membrane protein 119774 7562471 JTY_0106 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002643175.1 117789 D 561275 CDS YP_002643176.1 224988489 7561024 complement(119990..122248) 1 NC_012207.1 Differs from Rv0103c by 1aa, S22L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cation-transporter P-type ATPase B 122248 ctpB 7561024 ctpB Mycobacterium bovis BCG str. Tokyo 172 cation-transporter P-type ATPase B YP_002643176.1 119990 R 561275 CDS YP_002643177.1 224988490 7563132 122392..123906 1 NC_012207.1 hypothetical protein 123906 7563132 JTY_0108 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643177.1 122392 D 561275 CDS YP_002643178.1 224988491 7561025 complement(124055..124339) 1 NC_012207.1 required for 70S ribosome assembly; 50S ribosomal protein L28 124339 rpmB 7561025 rpmB Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L28 YP_002643178.1 124055 R 561275 CDS YP_002643179.1 224988492 7560714 124449..125645 1 NC_012207.1 hypothetical protein 125645 7560714 JTY_0110 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643179.1 124449 D 561275 CDS YP_002643180.1 224988493 7561026 complement(125740..130617) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-T) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv differs from Rv0107c by 3aa, V136A, P1247S, S1327A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cation-transporter ATPase I 130617 ctpI 7561026 ctpI Mycobacterium bovis BCG str. Tokyo 172 cation-transporter ATPase I YP_002643180.1 125740 R 561275 CDS YP_002643181.1 224988494 7563139 complement(130971..131180) 1 NC_012207.1 hypothetical protein 131180 7563139 JTY_0112 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643181.1 130971 R 561275 CDS YP_002643182.1 224988495 7561027 131459..132949 1 NC_012207.1 Differs from Rv0109 by 1aa, G346R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PE-PGRS family protein 132949 PE_PGRS1 7561027 PE_PGRS1 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002643182.1 131459 D 561275 CDS YP_002643183.1 224988496 7561748 133097..133846 1 NC_012207.1 integral membrane protein 133846 7561748 JTY_0114 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002643183.1 133097 D 561275 CDS YP_002643184.1 224988497 7561028 134027..136084 1 NC_012207.1 transmembrane acyltransferase 136084 7561028 JTY_0115 Mycobacterium bovis BCG str. Tokyo 172 transmembrane acyltransferase YP_002643184.1 134027 D 561275 CDS YP_002643185.1 224988498 7561029 136366..137322 1 NC_012207.1 gdp-mannose 4,6-dehydratase 137322 gca 7561029 gca Mycobacterium bovis BCG str. Tokyo 172 gdp-mannose 4,6-dehydratase YP_002643185.1 136366 D 561275 CDS YP_002643186.1 224988499 7561906 137396..137986 1 NC_012207.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 137986 gmhA 7561906 gmhA Mycobacterium bovis BCG str. Tokyo 172 phosphoheptose isomerase YP_002643186.1 137396 D 561275 CDS YP_002643187.1 224988500 7563270 138018..138590 1 NC_012207.1 Differs from Rv0114 by 1aa, R121G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; dehydratase 138590 7563270 JTY_0118 Mycobacterium bovis BCG str. Tokyo 172 dehydratase YP_002643187.1 138018 D 561275 CDS YP_002643188.1 224988501 7561030 138590..139657 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-c) equivalent to Mycobacterium tuberculosis H37Rv position 139559, leads to shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. In addition, in Mycobacterium bovis, a single base insertion, at position equivalent to 138823, leads to a different NH2 part; sugar kinase 139657 7561030 JTY_0119 Mycobacterium bovis BCG str. Tokyo 172 sugar kinase YP_002643188.1 138590 D 561275 CDS YP_002643189.1 224988502 7561031 complement(140345..141100) 1 NC_012207.1 hypothetical protein 141100 7561031 JTY_0120 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643189.1 140345 R 561275 CDS YP_002643190.1 224988503 7561032 141278..142222 1 NC_012207.1 oxidative stress response regulatory protein 142222 oxyS 7561032 oxyS Mycobacterium bovis BCG str. Tokyo 172 oxidative stress response regulatory protein YP_002643190.1 141278 D 561275 CDS YP_002643191.1 224988504 7562506 complement(142206..143954) 1 NC_012207.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase 143954 oxcA 7562506 oxcA Mycobacterium bovis BCG str. Tokyo 172 oxalyl-CoA decarboxylase YP_002643191.1 142206 R 561275 CDS YP_002643192.1 224988505 7562505 144127..145704 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 145704 fadD7 7562505 fadD7 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002643192.1 144127 D 561275 CDS YP_002643193.1 224988506 7563355 complement(145705..147849) 1 NC_012207.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 147849 fusA2b 7563355 fusA2b Mycobacterium bovis BCG str. Tokyo 172 elongation factor G YP_002643193.1 145705 R 561275 CDS YP_002643194.1 224988507 7561889 complement(147985..148419) 1 NC_012207.1 hypothetical protein 148419 7561889 JTY_0125 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643194.1 147985 R 561275 CDS YP_002643195.1 224988508 7561033 148568..148936 1 NC_012207.1 hypothetical protein 148936 7561033 JTY_0126 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643195.1 148568 D 561275 CDS YP_002643196.1 224988509 7561034 148933..149301 1 NC_012207.1 hypothetical protein 149301 7561034 JTY_0127 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643196.1 148933 D 561275 CDS YP_002643197.1 224988510 7561035 149610..151226 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 180 bp insertion leads to a longer product in the 3' direction compared to its homolog in Mycobacterium tuberculosis strain H37Rv (538 aa versus 487 aa); PE-PGRS family protein 151226 PE_PGRS2 7561035 PE_PGRS2 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002643197.1 149610 D 561275 CDS YP_002643198.1 224988511 7561759 151378..152445 1 NC_012207.1 serine protease 152445 pepA 7561759 pepA Mycobacterium bovis BCG str. Tokyo 172 serine protease YP_002643198.1 151378 D 561275 CDS YP_002643199.1 224988512 7561741 152554..154359 1 NC_012207.1 trehalose synthase 154359 treS 7561741 treS Mycobacterium bovis BCG str. Tokyo 172 trehalose synthase YP_002643199.1 152554 D 561275 CDS YP_002643200.1 224988513 7561868 154462..155829 1 NC_012207.1 Differs from Rv0127 by 1aa, P18S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 155829 7561868 JTY_0131 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643200.1 154462 D 561275 CDS YP_002643201.1 224988514 7561036 155897..156676 1 NC_012207.1 transmembrane protein 156676 7561036 JTY_0132 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643201.1 155897 D 561275 CDS YP_002643202.1 224988515 7561037 complement(156808..157830) 1 NC_012207.1 antigen 85-C 157830 fbpC 7561037 fbpC Mycobacterium bovis BCG str. Tokyo 172 antigen 85-C YP_002643202.1 156808 R 561275 CDS YP_002643203.1 224988516 7563402 158077..158532 1 NC_012207.1 hypothetical protein 158532 7563402 JTY_0134 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643203.1 158077 D 561275 CDS YP_002643204.1 224988517 7561038 complement(158545..159888) 1 NC_012207.1 acyl-CoA dehydrogenase 159888 fadE1 7561038 fadE1 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002643204.1 158545 R 561275 CDS YP_002643205.1 224988518 7563358 complement(159930..161012) 1 NC_012207.1 Differs from Mb0137c by 1aa, E147K in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; F420-dependent glucose-6-phosphate dehydrogenase 161012 fgd2 7563358 fgd2 Mycobacterium bovis BCG str. Tokyo 172 F420-dependent glucose-6-phosphate dehydrogenase YP_002643205.1 159930 R 561275 CDS YP_002643206.1 224988519 7563413 161099..161581 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis AF2122/97, codon 161 is TAC and in Mycobacterium bovis BCG Pasteur and BCG Tokyo, TAA; acetyltransferase 161581 7563413 JTY_0137 Mycobacterium bovis BCG str. Tokyo 172 acetyltransferase YP_002643206.1 161099 D 561275 CDS YP_002643207.1 224988520 7564171 complement(162874..163479) 1 NC_012207.1 transcriptional regulatory protein 163479 7564171 JTY_0141 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643207.1 162874 R 561275 CDS YP_002643208.1 224988521 7564172 163596..164921 1 NC_012207.1 cytochrome p450 138 164921 cyp138 7564172 cyp138 Mycobacterium bovis BCG str. Tokyo 172 cytochrome p450 138 YP_002643208.1 163596 D 561275 CDS YP_002643209.1 224988522 7563164 complement(164942..165490) 1 NC_012207.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 165490 msrA 7563164 msrA Mycobacterium bovis BCG str. Tokyo 172 methionine sulfoxide reductase A YP_002643209.1 164942 R 561275 CDS YP_002643210.1 224988523 7563565 165553..166056 1 NC_012207.1 Differs from Mb0143 by 1aa, D96G in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 166056 7563565 JTY_0144 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643210.1 165553 D 561275 CDS YP_002643211.1 224988524 7564173 166057..167079 1 NC_012207.1 Differs from Mb0144 by 1aa, R227H in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 167079 7564173 JTY_0145 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002643211.1 166057 D 561275 CDS YP_002643212.1 224988525 7564174 167140..167520 1 NC_012207.1 hypothetical protein 167520 7564174 JTY_0146 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643212.1 167140 D 561275 CDS YP_002643213.1 224988526 7564175 complement(167501..167911) 1 NC_012207.1 hypothetical protein 167911 7564175 JTY_0147 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643213.1 167501 R 561275 CDS YP_002643214.1 224988527 7564176 167941..168867 1 NC_012207.1 hypothetical protein 168867 7564176 JTY_0148 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643214.1 167941 D 561275 CDS YP_002643215.1 224988528 7564177 complement(168934..170412) 1 NC_012207.1 Differs from Rv0143c by 1aa, L34F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 170412 7564177 JTY_0149 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643215.1 168934 R 561275 CDS YP_002643216.1 224988529 7564178 170514..171356 1 NC_012207.1 possibly TetR-family; transcriptional regulatory protein 171356 7564178 JTY_0150 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643216.1 170514 D 561275 CDS YP_002643217.1 224988530 7564179 171445..172398 1 NC_012207.1 hypothetical protein 172398 7564179 JTY_0151 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643217.1 171445 D 561275 CDS YP_002643218.1 224988531 7564180 172441..173373 1 NC_012207.1 hypothetical protein 173373 7564180 JTY_0152 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643218.1 172441 D 561275 CDS YP_002643219.1 224988532 7564181 173468..174988 1 NC_012207.1 aldehyde dehydrogenase 174988 7564181 JTY_0153 Mycobacterium bovis BCG str. Tokyo 172 aldehyde dehydrogenase YP_002643219.1 173468 D 561275 CDS YP_002643220.1 224988533 7564182 175063..175923 1 NC_012207.1 short-chain type dehydrogenase/reductase 175923 7564182 JTY_0154 Mycobacterium bovis BCG str. Tokyo 172 short-chain type dehydrogenase/reductase YP_002643220.1 175063 D 561275 CDS YP_002643221.1 224988534 7564183 175930..176898 1 NC_012207.1 quinone oxidoreductase 176898 7564183 JTY_0155 Mycobacterium bovis BCG str. Tokyo 172 quinone oxidoreductase YP_002643221.1 175930 D 561275 CDS YP_002643222.1 224988535 7564184 complement(176895..177182) 1 NC_012207.1 hypothetical protein 177182 7564184 JTY_0156 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643222.1 176895 R 561275 CDS YP_002643223.1 224988536 7564185 complement(177773..179539) 1 NC_012207.1 Differs from Rv0151c by 1aa, R26G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PE family protein 179539 PE1 7564185 PE1 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002643223.1 177773 R 561275 CDS YP_002643224.1 224988537 7561709 complement(179549..181126) 1 NC_012207.1 PE family protein 181126 PE2 7561709 PE2 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002643224.1 179549 R 561275 CDS YP_002643225.1 224988538 7561720 complement(181385..182215) 1 NC_012207.1 Differs from Rv0153c by 1aa, G105D in BCG Pasteur and BCG Tokyo; phosphotyrosine protein phosphatase 182215 ptbB 7561720 ptbB Mycobacterium bovis BCG str. Tokyo 172 phosphotyrosine protein phosphatase YP_002643225.1 181385 R 561275 CDS YP_002643226.1 224988539 7560850 complement(182217..183428) 1 NC_012207.1 acyl-CoA dehydrogenase 183428 fadE2 7560850 fadE2 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002643226.1 182217 R 561275 CDS YP_002643227.1 224988540 7563368 183852..184952 1 NC_012207.1 NAD(P) transhydrogenase subunit alpha 184952 pntAa 7563368 pntAa Mycobacterium bovis BCG str. Tokyo 172 NAD(P) transhydrogenase subunit alpha YP_002643227.1 183852 D 561275 CDS YP_002643228.1 224988541 7562136 184953..185285 1 NC_012207.1 Differs from Rv0156 by 1aa, C2Y in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; NAD(P) transhydrogenase subunit alpha 185285 pntAb 7562136 pntAb Mycobacterium bovis BCG str. Tokyo 172 NAD(P) transhydrogenase subunit alpha YP_002643228.1 184953 D 561275 CDS YP_002643229.1 224988542 7562137 185282..186709 1 NC_012207.1 NAD(P) transhydrogenase subunit beta 186709 pntB 7562137 pntB Mycobacterium bovis BCG str. Tokyo 172 NAD(P) transhydrogenase subunit beta YP_002643229.1 185282 D 561275 CDS YP_002643230.1 224988543 7562138 187015..187659 1 NC_012207.1 possibly TetR-family; transcriptional regulatory protein 187659 7562138 JTY_0164 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643230.1 187015 D 561275 CDS YP_002643231.1 224988544 7564186 complement(187663..189069) 1 NC_012207.1 Differs from Rv0159c by 1aa, T255P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PE family protein 189069 PE3 7564186 PE3 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002643231.1 187663 R 561275 CDS YP_002643232.1 224988545 7561730 complement(189161..190669) 1 NC_012207.1 Differs from Rv0160c by 2aa, T116A, T211A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PE family protein 190669 PE4 7561730 PE4 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002643232.1 189161 R 561275 CDS YP_002643233.1 224988546 7561735 190837..192186 1 NC_012207.1 oxidoreductase 192186 7561735 JTY_0167 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002643233.1 190837 D 561275 CDS YP_002643234.1 224988547 7564187 complement(192214..193365) 1 NC_012207.1 Differs from Rv0162c and Mb0167c by 1aa, R41H in BCG Pasteur and BCG Tokyo; zinc-type alcohol dehydrogenase e subunit 193365 adhE1 7564187 adhE1 Mycobacterium bovis BCG str. Tokyo 172 zinc-type alcohol dehydrogenase e subunit YP_002643234.1 192214 R 561275 CDS YP_002643235.1 224988548 7563945 193347..193802 1 NC_012207.1 hypothetical protein 193802 7563945 JTY_0169 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643235.1 193347 D 561275 CDS YP_002643236.1 224988549 7564188 193856..194341 1 NC_012207.1 hypothetical protein 194341 TB18.5 7564188 TB18.5 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643236.1 193856 D 561275 CDS YP_002643237.1 224988550 7561830 complement(194355..195170) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv0165c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a 2bp insertion (*-CC) leads to a product with a different COOH terminus; probably GntR-family; transcriptional regulatory protein 195170 7561830 JTY_0171 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643237.1 194355 R 561275 CDS YP_002643238.1 224988551 7564189 195225..196889 1 NC_012207.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 196889 fadD5 7564189 fadD5 Mycobacterium bovis BCG str. Tokyo 172 long-chain-fatty-acid--CoA ligase YP_002643238.1 195225 D 561275 CDS YP_002643239.1 224988552 7563353 197093..197890 1 NC_012207.1 hypothetical protein 197890 yrbE1A 7563353 yrbE1A Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643239.1 197093 D 561275 CDS YP_002643240.1 224988553 7561706 197892..198761 1 NC_012207.1 hypothetical protein 198761 yrbE1B 7561706 yrbE1B Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643240.1 197892 D 561275 CDS YP_002643241.1 224988554 7561451 198766..200130 1 NC_012207.1 Differs from Rv0169 by 2aa, A313S, S359P. Differs from Rv0169 by 2aa, A313S, S359P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; MCE-family protein 200130 mce1A 7561451 mce1A Mycobacterium bovis BCG str. Tokyo 172 MCE-family protein YP_002643241.1 198766 D 561275 CDS YP_002643242.1 224988555 7564432 200127..201167 1 NC_012207.1 Differs from Rv0170 by 1aa, T179I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; MCE-family protein 201167 mce1B 7564432 mce1B Mycobacterium bovis BCG str. Tokyo 172 MCE-family protein YP_002643242.1 200127 D 561275 CDS YP_002643243.1 224988556 7564433 201164..202711 1 NC_012207.1 Differs from Rv0171 by 1aa, D212E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; MCE-family protein 202711 mce1C 7564433 mce1C Mycobacterium bovis BCG str. Tokyo 172 MCE-family protein YP_002643243.1 201164 D 561275 CDS YP_002643244.1 224988557 7564434 202708..204300 1 NC_012207.1 MCE-family protein 204300 mce1D 7564434 mce1D Mycobacterium bovis BCG str. Tokyo 172 MCE-family protein YP_002643244.1 202708 D 561275 CDS YP_002643245.1 224988558 7564435 204297..205469 1 NC_012207.1 MCE-family lipoprotein mce1E 205469 lprK 7564435 lprK Mycobacterium bovis BCG str. Tokyo 172 MCE-family lipoprotein mce1E YP_002643245.1 204297 D 561275 CDS YP_002643246.1 224988559 7560529 205463..207010 1 NC_012207.1 Differs from Rv0174 by 1aa, P370L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; MCE-family protein 207010 mce1F 7560529 mce1F Mycobacterium bovis BCG str. Tokyo 172 MCE-family protein YP_002643246.1 205463 D 561275 CDS YP_002643247.1 224988560 7564436 207046..207687 1 NC_012207.1 MCE associated membrane protein 207687 7564436 JTY_0181 Mycobacterium bovis BCG str. Tokyo 172 MCE associated membrane protein YP_002643247.1 207046 D 561275 CDS YP_002643248.1 224988561 7564190 207684..208652 1 NC_012207.1 Differs from Mb0182 by 1aa, S285N, and from Rv0176 by 3aa, S285N, S290Q, A291S in BCG Pasteur and BCG Tokyo; MCE associated transmembrane protein 208652 7564190 JTY_0182 Mycobacterium bovis BCG str. Tokyo 172 MCE associated transmembrane protein YP_002643248.1 207684 D 561275 CDS YP_002643249.1 224988562 7564191 208649..209203 1 NC_012207.1 MCE associated protein 209203 7564191 JTY_0183 Mycobacterium bovis BCG str. Tokyo 172 MCE associated protein YP_002643249.1 208649 D 561275 CDS YP_002643250.1 224988563 7564192 209170..209904 1 NC_012207.1 MCE associated membrane protein 209904 7564192 JTY_0184 Mycobacterium bovis BCG str. Tokyo 172 MCE associated membrane protein YP_002643250.1 209170 D 561275 CDS YP_002643251.1 224988564 7564193 complement(209935..211044) 1 NC_012207.1 Differs from Rv0179c by 1aa, H124R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 211044 lprO 7564193 lprO Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002643251.1 209935 R 561275 CDS YP_002643252.1 224988565 7560532 complement(211124..212482) 1 NC_012207.1 transmembrane protein 212482 7560532 JTY_0186 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643252.1 211124 R 561275 CDS YP_002643253.1 224988566 7564194 complement(212509..213243) 1 NC_012207.1 hypothetical protein 213243 7564194 JTY_0187 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643253.1 212509 R 561275 CDS YP_002643254.1 224988567 7564195 complement(213260..214372) 1 NC_012207.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; RNA polymerase factor sigma-70 214372 sigG 7564195 sigG Mycobacterium bovis BCG str. Tokyo 172 RNA polymerase factor sigma-70 YP_002643254.1 213260 R 561275 CDS YP_002643255.1 224988568 7561791 214320..215159 1 NC_012207.1 lysophospholipase 215159 7561791 JTY_0189 Mycobacterium bovis BCG str. Tokyo 172 lysophospholipase YP_002643255.1 214320 D 561275 CDS YP_002643256.1 224988569 7564196 215201..215950 1 NC_012207.1 hypothetical protein 215950 7564196 JTY_0190 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643256.1 215201 D 561275 CDS YP_002643257.1 224988570 7564197 215947..216456 1 NC_012207.1 hypothetical protein 216456 7564197 JTY_0191 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643257.1 215947 D 561275 CDS YP_002643258.1 224988571 7564198 216501..218576 1 NC_012207.1 Differs from Mb0192 by 1aa, S504I, and from Rv0186 by 2aa, S504I, R532P in BCG Pasteur and BCG Tokyo; beta-glucosidase 218576 bglS 7564198 bglS Mycobacterium bovis BCG str. Tokyo 172 beta-glucosidase YP_002643258.1 216501 D 561275 CDS YP_002643259.1 224988572 7562065 218937..219599 1 NC_012207.1 Differs from Rv0187 and Mb0193 by 1aa, V147A in BCG Pasteur and BCG Tokyo; O-methyltransferase 219599 7562065 JTY_0193 Mycobacterium bovis BCG str. Tokyo 172 O-methyltransferase YP_002643259.1 218937 D 561275 CDS YP_002643260.1 224988573 7564199 219718..220149 1 NC_012207.1 transmembrane protein 220149 7564199 JTY_0194 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643260.1 219718 D 561275 CDS YP_002643261.1 224988574 7564200 complement(220228..221955) 1 NC_012207.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 221955 ilvD 7564200 ilvD Mycobacterium bovis BCG str. Tokyo 172 dihydroxy-acid dehydratase YP_002643261.1 220228 R 561275 CDS YP_002643262.1 224988575 7562779 222103..222393 1 NC_012207.1 hypothetical protein 222393 7562779 JTY_0196 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643262.1 222103 D 561275 CDS YP_002643263.1 224988576 7564201 222521..223762 1 NC_012207.1 integral membrane protein 223762 7564201 JTY_0197 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002643263.1 222521 D 561275 CDS YP_002643264.1 224988577 7564202 223839..224897 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv0192 and Rv0192A exist as 2 genes with an overlap region. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-g) leads to a single product. Differs from Mb0198 by 1aa, A279V and from Rv0192 by 2aa, P113S, A279V in BCG Pasteur and BCG Tokyo; hypothetical protein 224897 7564202 JTY_0198 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643264.1 223839 D 561275 CDS YP_002643265.1 224988578 7564203 complement(224957..226804) 1 NC_012207.1 Differs from Rv0193c and Mb0199c by 1aa, E417K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 226804 7564203 JTY_0199 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643265.1 224957 R 561275 CDS YP_002643266.1 224988579 7564204 227111..230695 1 NC_012207.1 Differs from Mb0200 by 1aa, I49V, and from Rv0194 by 2aa, T74M, M223T in BCG Pasteur and BCG Tokyo; drugs-transport transmembrane ATP-binding protein ABC transporter 230695 7564204 JTY_0200 Mycobacterium bovis BCG str. Tokyo 172 drugs-transport transmembrane ATP-binding protein ABC transporter YP_002643266.1 227111 D 561275 CDS YP_002643267.1 224988580 7564205 231133..231768 1 NC_012207.1 probably LuxR-family; two component transcriptional regulatory protein 231768 7564205 JTY_0201 Mycobacterium bovis BCG str. Tokyo 172 two component transcriptional regulatory protein YP_002643267.1 231133 D 561275 CDS YP_002643268.1 224988581 7564206 231881..232465 1 NC_012207.1 transcriptional regulatory protein 232465 7564206 JTY_0202 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643268.1 231881 D 561275 CDS YP_002643269.1 224988582 7564207 232465..234711 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transversion (T-G) introduces a stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (748 aa versus 762 aa). Differs from Rv0197 by 1aa, S378R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 234711 7564207 JTY_0203 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002643269.1 232465 D 561275 CDS YP_002643270.1 224988583 7564208 complement(234752..236743) 1 NC_012207.1 zinc metalloprotease 236743 7564208 JTY_0204 Mycobacterium bovis BCG str. Tokyo 172 zinc metalloprotease YP_002643270.1 234752 R 561275 CDS YP_002643271.1 224988584 7564209 236786..237445 1 NC_012207.1 hypothetical protein 237445 7564209 JTY_0205 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643271.1 236786 D 561275 CDS YP_002643272.1 224988585 7564210 237442..238131 1 NC_012207.1 transmembrane protein 238131 7564210 JTY_0206 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643272.1 237442 D 561275 CDS YP_002643273.1 224988586 7564211 complement(238128..238631) 1 NC_012207.1 hypothetical protein 238631 7564211 JTY_0207 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643273.1 238128 R 561275 CDS YP_002643274.1 224988587 7564212 complement(238628..241528) 1 NC_012207.1 transmembrane transport protein 241528 mmpL11 7564212 mmpL11 Mycobacterium bovis BCG str. Tokyo 172 transmembrane transport protein YP_002643274.1 238628 R 561275 CDS YP_002643275.1 224988588 7564481 241750..242160 1 NC_012207.1 Differs from Rv0203 and Mb0209 by 1aa, T88K in BCG Pasteur and BCG Tokyo; hypothetical protein 242160 7564481 JTY_0209 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643275.1 241750 D 561275 CDS YP_002643276.1 224988589 7564213 complement(242212..243495) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, the presence of a more likely start codon leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (427 aa versus 412 aa). Differs from Rv0204c by 1aa, L321V in BCG Pasteur and BCG Tokyo; transmembrane protein 243495 7564213 JTY_0210 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643276.1 242212 R 561275 CDS YP_002643277.1 224988590 7564214 243620..244723 1 NC_012207.1 Differs from Rv0205 by 1aa, R72H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; transmembrane protein 244723 7564214 JTY_0211 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643277.1 243620 D 561275 CDS YP_002643278.1 224988591 7564215 complement(244720..247554) 1 NC_012207.1 Differs from Rv0206c by 2aa, I384F, E466D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; conserved transmembrane transport protein 247554 mmpL3 7564215 mmpL3 Mycobacterium bovis BCG str. Tokyo 172 conserved transmembrane transport protein YP_002643278.1 244720 R 561275 CDS YP_002643279.1 224988592 7564488 complement(247620..248348) 1 NC_012207.1 hypothetical protein 248348 7564488 JTY_0213 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643279.1 247620 R 561275 CDS YP_002643280.1 224988593 7564216 complement(248351..249142) 1 NC_012207.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 249142 trmB 7564216 trmB Mycobacterium bovis BCG str. Tokyo 172 tRNA (guanine-N(7)-)-methyltransferase YP_002643280.1 248351 R 561275 CDS YP_002643281.1 224988594 7564217 249274..250359 1 NC_012207.1 Differs from Rv0209 by 1aa, A162V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 250359 7564217 JTY_0215 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643281.1 249274 D 561275 CDS YP_002643282.1 224988595 7564218 250356..251834 1 NC_012207.1 Differs from Rv0210 by 1aa, T486A in Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 251834 7564218 JTY_0216 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643282.1 250356 D 561275 CDS YP_002643283.1 224988596 7564219 252018..253838 1 NC_012207.1 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP; phosphoenolpyruvate carboxykinase 253838 pckA 7564219 pckA Mycobacterium bovis BCG str. Tokyo 172 phosphoenolpyruvate carboxykinase YP_002643283.1 252018 D 561275 CDS YP_002643284.1 224988597 7562523 complement(253905..254876) 1 NC_012207.1 probably AsnC-family; transcriptional regulatory protein 254876 nadR 7562523 nadR Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643284.1 253905 R 561275 CDS YP_002643285.1 224988598 7563590 complement(254873..256186) 1 NC_012207.1 methyltransferase 256186 7563590 JTY_0219 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase YP_002643285.1 254873 R 561275 CDS YP_002643286.1 224988599 7564220 256300..257913 1 NC_012207.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 257913 fadD4 7564220 fadD4 Mycobacterium bovis BCG str. Tokyo 172 long-chain-fatty-acid--CoA ligase YP_002643286.1 256300 D 561275 CDS YP_002643287.1 224988600 7563352 complement(257955..259121) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 29 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (388 aa versus 357 aa). Differs from Mb0221c by 1aa, S361A in BCG Pasteur and BCG Tokyo; acyl-CoA dehydrogenase 259121 fadE3 7563352 fadE3 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002643287.1 257955 R 561275 CDS YP_002643288.1 224988601 7563379 259178..260191 1 NC_012207.1 hypothetical protein 260191 7563379 JTY_0222 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643288.1 259178 D 561275 CDS YP_002643289.1 224988602 7564221 complement(260188..261096) 1 NC_012207.1 Differs from Rv0217c by 1aa T184P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; esterase 261096 lipW 7564221 lipW Mycobacterium bovis BCG str. Tokyo 172 esterase YP_002643289.1 260188 R 561275 CDS YP_002643290.1 224988603 7562849 261189..262517 1 NC_012207.1 Differs from Rv0218 by 2aa, R316C, N413D; transmembrane protein 262517 7562849 JTY_0224 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643290.1 261189 D 561275 CDS YP_002643291.1 224988604 7564222 262519..263067 1 NC_012207.1 transmembrane protein 263067 7564222 JTY_0225 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643291.1 262519 D 561275 CDS YP_002643292.1 224988605 7564223 263077..264318 1 NC_012207.1 esterase 264318 lipC 7564223 lipC Mycobacterium bovis BCG str. Tokyo 172 esterase YP_002643292.1 263077 D 561275 CDS YP_002643293.1 224988606 7562831 264332..265105 1 NC_012207.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, and BCG Tokyo, RD10, a 1902 bp deletion leads to a shorter product with a different COOH part, compared to its homolog in Mycobacterium tuberculosis strain H37Rv (257 aa versus 469 aa). It also leads to the deletion of the next protein, echA1 (Rv0222) in BCG Pasteur and BCG Tokyo; hypothetical protein 265105 7562831 JTY_0227 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643293.1 264332 D 561275 CDS YP_002643294.1 224988607 7564224 complement(264971..265780) 1 NC_012207.1 In mycobacterium bovis strain AF2122/97, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, RD10, a 1902 bp deletion, compared to Mycobacterium tuberculosis H37Rv, truncates Rv0221c and Rv0223c and removes Rv0222c. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base deletion at position equivalent to Mycobacterium tuberculosis H37Rv 267419-267419 (*-C) splits gene into two parts compared to its homologs in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis AF2122/97 (116 aa and 269 aa, versus 487 aa and 385 aa, respectively. Also has same 1 bp insertion, as Mycobacterium bovis AF2122/97, at position equivalent to Mycobacterium tuberculosis H37Rv base 266743. Deletion in Mycobacterium bovis, bovis BCG Pasteur, and BCG Tokyo of region RD10 leads to a different COOH part compared to Mycobacterium tuberculosis strain H37Rv. Maybe pseudogene.; aldehyde dehydrogenase 265780 7564224 JTY_0228 Mycobacterium bovis BCG str. Tokyo 172 aldehyde dehydrogenase YP_002643294.1 264971 R 561275 CDS YP_002643295.1 224988608 7564225 complement(265777..266127) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base deletion at position equivalent to Mycobacterium tuberculosis H37Rv2 267419-267419 (*-C) splits gene into two parts compared to its homologs in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis AF2122/97 (116 aa and 269 aa, versus 487 aa and 385 aa, respectively. Also has same 1 bp insertion, as Mycobacterium bovis AF2122/97, at position equivalent to Mycobacterium tuberculosis H37Rv2 base 266743. May be pseudogene; aldehyde dehydrogenase 266127 7564225 JTY_0229 Mycobacterium bovis BCG str. Tokyo 172 aldehyde dehydrogenase YP_002643295.1 265777 R 561275 CDS YP_002643296.1 224988609 7564226 complement(266226..266990) 1 NC_012207.1 Differs from Rv0224c by 1aa, L117F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methyltransferase 266990 7564226 JTY_0230 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase YP_002643296.1 266226 R 561275 CDS YP_002643297.1 224988610 7564227 267026..268180 1 NC_012207.1 hypothetical protein 268180 7564227 JTY_0231 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643297.1 267026 D 561275 CDS YP_002643298.1 224988611 7564228 complement(268197..269927) 1 NC_012207.1 transmembrane protein 269927 7564228 JTY_0232 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643298.1 268197 R 561275 CDS YP_002643299.1 224988612 7564229 complement(269937..271202) 1 NC_012207.1 Differs from Rv0227c by 1aa, R29S, and from Mb0232c by 1aa, S392N in BCG Pasteur and BCG Tokyo; hypothetical protein 271202 7564229 JTY_0233 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643299.1 269937 R 561275 CDS YP_002643300.1 224988613 7564230 271418..272641 1 NC_012207.1 integral membrane acyltransferase 272641 7564230 JTY_0234 Mycobacterium bovis BCG str. Tokyo 172 integral membrane acyltransferase YP_002643300.1 271418 D 561275 CDS YP_002643301.1 224988614 7564231 complement(272669..273349) 1 NC_012207.1 hypothetical protein 273349 7564231 JTY_0235 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643301.1 272669 R 561275 CDS YP_002643302.1 224988615 7564232 complement(273346..274326) 1 NC_012207.1 Differs from Rv0230c by 1aa, E199D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; phosphotriesterase 274326 php 7564232 php Mycobacterium bovis BCG str. Tokyo 172 phosphotriesterase YP_002643302.1 273346 R 561275 CDS YP_002643303.1 224988616 7562419 274421..276127 1 NC_012207.1 acyl-CoA dehydrogenase 276127 fadE4 7562419 fadE4 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002643303.1 274421 D 561275 CDS YP_002643304.1 224988617 7563387 276262..276951 1 NC_012207.1 probably TetR/AcrR-family; transcriptional regulatory protein 276951 7563387 JTY_0238 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643304.1 276262 D 561275 CDS YP_002643305.1 224988618 7564233 276948..277892 1 NC_012207.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit beta 277892 nrdB 7564233 nrdB Mycobacterium bovis BCG str. Tokyo 172 ribonucleotide-diphosphate reductase subunit beta YP_002643305.1 276948 D 561275 CDS YP_002643306.1 224988619 7562464 complement(277968..279503) 1 NC_012207.1 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinic semialdehyde dehydrogenase 279503 gabD1 7562464 gabD1 Mycobacterium bovis BCG str. Tokyo 172 succinic semialdehyde dehydrogenase YP_002643306.1 277968 R 561275 CDS YP_002643307.1 224988620 7561891 complement(279529..280977) 1 NC_012207.1 transmembrane protein 280977 7561891 JTY_0241 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643307.1 279529 R 561275 CDS YP_002643308.1 224988621 7564234 complement(281012..285214) 1 NC_012207.1 Differs from Rv0236c by 3aa, V412M, A990T, G1080S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 285214 7564234 JTY_0242 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643308.1 281012 R 561275 CDS YP_002643309.1 224988622 7564235 complement(285261..285434) 1 NC_012207.1 hypothetical protein 285434 7564235 JTY_0243 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643309.1 285261 R 561275 CDS YP_002643310.1 224988623 7564236 285549..286715 1 NC_012207.1 Differs from Rv0237 by 1aa, L129V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 286715 lpqI 7564236 lpqI Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002643310.1 285549 D 561275 CDS YP_002643311.1 224988624 7560501 286791..287405 1 NC_012207.1 probably TetR-family; transcriptional regulatory protein 287405 7560501 JTY_0245 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643311.1 286791 D 561275 CDS YP_002643312.1 224988625 7564237 287467..287700 1 NC_012207.1 hypothetical protein 287700 7564237 JTY_0246 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643312.1 287467 D 561275 CDS YP_002643313.1 224988626 7564238 287708..288145 1 NC_012207.1 Differs from Rv0240 by 1aa, S31A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 288145 7564238 JTY_0247 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643313.1 287708 D 561275 CDS YP_002643314.1 224988627 7564239 complement(288175..289017) 1 NC_012207.1 hypothetical protein 289017 7564239 JTY_0248 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643314.1 288175 R 561275 CDS YP_002643315.1 224988628 7564240 complement(289028..290392) 1 NC_012207.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 290392 fabG 7564240 fabG Mycobacterium bovis BCG str. Tokyo 172 3-ketoacyl-ACP reductase YP_002643315.1 289028 R 561275 CDS YP_002643316.1 224988629 7562902 290534..291856 1 NC_012207.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 291856 fadA2 7562902 fadA2 Mycobacterium bovis BCG str. Tokyo 172 acetyl-CoA acetyltransferase YP_002643316.1 290534 D 561275 CDS YP_002643317.1 224988630 7562905 complement(292162..293997) 1 NC_012207.1 Differs from Mb0250c by 1aa, N503D and from Rv0244c by 3aa, R394K, A479E, N503D in BCG Pasteur and BCG Tokyo; acyl-CoA dehydrogenase 293997 fadE5 7562905 fadE5 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002643317.1 292162 R 561275 CDS YP_002643318.1 224988631 7563388 294369..294857 1 NC_012207.1 oxidoreductase 294857 7563388 JTY_0252 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002643318.1 294369 D 561275 CDS YP_002643319.1 224988632 7564241 295173..296483 1 NC_012207.1 Differs from Mb0252 by 1aa, A129V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein 296483 7564241 JTY_0253 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002643319.1 295173 D 561275 CDS YP_002643320.1 224988633 7564242 complement(296480..297226) 1 NC_012207.1 catalyzes the fumarate and succinate interconversion; fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source; fumarate reductase iron-sulfur subunit 297226 7564242 JTY_0254 Mycobacterium bovis BCG str. Tokyo 172 fumarate reductase iron-sulfur subunit YP_002643320.1 296480 R 561275 CDS YP_002643321.1 224988634 7564243 complement(297227..299167) 1 NC_012207.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 299167 sdhA 7564243 sdhA Mycobacterium bovis BCG str. Tokyo 172 succinate dehydrogenase flavoprotein subunit YP_002643321.1 297227 R 561275 CDS YP_002643322.1 224988635 7560761 complement(299198..300019) 1 NC_012207.1 succinate dehydrogenase membrane anchor subunit 300019 7560761 JTY_0256 Mycobacterium bovis BCG str. Tokyo 172 succinate dehydrogenase membrane anchor subunit YP_002643322.1 299198 R 561275 CDS YP_002643323.1 224988636 7564244 complement(300099..300392) 1 NC_012207.1 hypothetical protein 300392 7564244 JTY_0257 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643323.1 300099 R 561275 CDS YP_002643324.1 224988637 7564245 complement(300537..301016) 1 NC_012207.1 heat shock protein 301016 hsp 7564245 hsp Mycobacterium bovis BCG str. Tokyo 172 heat shock protein YP_002643324.1 300537 R 561275 CDS YP_002643325.1 224988638 7563328 301230..303791 1 NC_012207.1 fad flavoprotein; nitrite reductase [NAD(P)H] large subunit 303791 nirB 7563328 nirB Mycobacterium bovis BCG str. Tokyo 172 nitrite reductase [NAD(P)H] large subunit YP_002643325.1 301230 D 561275 CDS YP_002643326.1 224988639 7562462 303817..304173 1 NC_012207.1 nitrite reductase [NAD(P)H] small subunit 304173 nirD 7562462 nirD Mycobacterium bovis BCG str. Tokyo 172 nitrite reductase [NAD(P)H] small subunit YP_002643326.1 303817 D 561275 CDS YP_002643327.1 224988640 7562463 complement(304189..304713) 1 NC_012207.1 cobinamide kinase, cobinamide phosphate guanylyltransferase; cobalamin biosynthesis protein 304713 cobU 7562463 cobU Mycobacterium bovis BCG str. Tokyo 172 cobalamin biosynthesis protein YP_002643327.1 304189 R 561275 CDS YP_002643328.1 224988641 7563119 complement(304738..306222) 1 NC_012207.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation; cobyric acid synthase 306222 cobQ1 7563119 cobQ1 Mycobacterium bovis BCG str. Tokyo 172 cobyric acid synthase YP_002643328.1 304738 R 561275 CDS YP_002643329.1 224988642 7563115 complement(306241..307911) 1 NC_012207.1 PPE family protein 307911 PPE2 7563115 PPE2 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002643329.1 306241 R 561275 CDS YP_002643330.1 224988643 7562156 308219..308437 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (C-T) leads to a truncated product in the 5' direction compared to Mycobacterium tuberculosis strain H37Rv (72 aa versus 124 aa); hypothetical protein 308437 7562156 JTY_0264 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643330.1 308219 D 561275 CDS YP_002643331.1 224988644 7564246 complement(308658..309113) 1 NC_012207.1 hypothetical protein 309113 7564246 JTY_0265 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643331.1 308658 R 561275 CDS YP_002643332.1 224988645 7564247 complement(309138..309881) 1 NC_012207.1 Differs from Rv0259c by 1aa, V182A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 309881 7564247 JTY_0266 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643332.1 309138 R 561275 CDS YP_002643333.1 224988646 7564248 complement(309878..311023) 1 NC_012207.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; bifunctional uroporphyrinogen-III synthetase/response regulator domain protein 311023 7564248 JTY_0267 Mycobacterium bovis BCG str. Tokyo 172 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein YP_002643333.1 309878 R 561275 CDS YP_002643334.1 224988647 7564249 complement(311123..312532) 1 NC_012207.1 integral membrane nitrite extrusion protein 312532 narK3 7564249 narK3 Mycobacterium bovis BCG str. Tokyo 172 integral membrane nitrite extrusion protein YP_002643334.1 311123 R 561275 CDS YP_002643335.1 224988648 7562451 complement(312673..313218) 1 NC_012207.1 aminoglycoside 2'-N-acetyltransferase 313218 aac 7562451 aac Mycobacterium bovis BCG str. Tokyo 172 aminoglycoside 2'-N-acetyltransferase YP_002643335.1 312673 R 561275 CDS YP_002643336.1 224988649 7564327 complement(313228..314130) 1 NC_012207.1 hypothetical protein 314130 7564327 JTY_0270 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643336.1 313228 R 561275 CDS YP_002643337.1 224988650 7564250 complement(314147..314779) 1 NC_012207.1 hypothetical protein 314779 7564250 JTY_0271 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643337.1 314147 R 561275 CDS YP_002643338.1 224988651 7563020 complement(314875..315867) 1 NC_012207.1 Differs from Rv0265c and Mb0271c by 1aa, C313Y in BCG Pasteur and BCG Tokyo; periplasmic iron-transport lipoprotein 315867 7563020 JTY_0272 Mycobacterium bovis BCG str. Tokyo 172 periplasmic iron-transport lipoprotein YP_002643338.1 314875 R 561275 CDS YP_002643339.1 224988652 7563021 complement(315889..319518) 1 NC_012207.1 5-oxoprolinase 319518 oplA 7563021 oplA Mycobacterium bovis BCG str. Tokyo 172 5-oxoprolinase YP_002643339.1 315889 R 561275 CDS YP_002643340.1 224988653 7562496 319695..321086 1 NC_012207.1 integral membrane nitrite extrusion protein 321086 narU 7562496 narU Mycobacterium bovis BCG str. Tokyo 172 integral membrane nitrite extrusion protein YP_002643340.1 319695 D 561275 CDS YP_002643341.1 224988654 7562453 complement(321128..321637) 1 NC_012207.1 hypothetical protein 321637 7562453 JTY_0275 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643341.1 321128 R 561275 CDS YP_002643342.1 224988655 7563022 complement(321702..322895) 1 NC_012207.1 hypothetical protein 322895 7563022 JTY_0276 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643342.1 321702 R 561275 CDS YP_002643343.1 224988656 7563023 322931..324613 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 324613 fadD2 7563023 fadD2 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002643343.1 322931 D 561275 CDS YP_002643344.1 224988657 7562926 complement(324630..326825) 1 NC_012207.1 acyl-CoA dehydrogenase 326825 fadE6 7562926 fadE6 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002643344.1 324630 R 561275 CDS YP_002643345.1 224988658 7563389 complement(326939..328072) 1 NC_012207.1 Differs from Mb0278c by 1aa, P164L in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 328072 7563389 JTY_0279 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643345.1 326939 R 561275 CDS YP_002643346.1 224988659 7563024 complement(328069..328689) 1 NC_012207.1 transcriptional regulatory protein 328689 7563024 JTY_0280 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643346.1 328069 R 561275 CDS YP_002643347.1 224988660 7563025 328786..329367 1 NC_012207.1 hypothetical protein 329367 7563025 JTY_0281 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643347.1 328786 D 561275 CDS YP_002643348.1 224988661 7563026 complement(329297..330022) 1 NC_012207.1 Differs from Rv0275c by 1aa, L24S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; possibly TetR-family; transcriptional regulatory protein 330022 7563026 JTY_0282 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643348.1 329297 R 561275 CDS YP_002643349.1 224988662 7563027 330112..331032 1 NC_012207.1 hypothetical protein 331032 7563027 JTY_0283 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643349.1 330112 D 561275 CDS YP_002643350.1 224988663 7563028 complement(331072..331500) 1 NC_012207.1 hypothetical protein 331500 7563028 JTY_0284 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643350.1 331072 R 561275 CDS YP_002643351.1 224988664 7563029 complement(331524..331781) 1 NC_012207.1 Differs by 1 aa, Q24* from Rv0227A and Mb0351A in BCG Pasteur and BCG Tokyo; antitoxin 331781 7563029 JTY_0285 Mycobacterium bovis BCG str. Tokyo 172 antitoxin YP_002643351.1 331524 R 561275 CDS YP_002643352.1 224988665 7561785 complement(331866..334616) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS3 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovs BCG Pasteur and BCG Tokyo, a large insertion leads to an extra copy of PE_PGRS3. Also, a frameshift due to single base deletion (T-*), splits this extra copy of PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b. Also differs from Mb0285c by an insertion of 144bp.; PE-PGRS family protein 334616 PE_PGRS3a 7561785 PE_PGRS3a Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002643352.1 331866 R 561275 CDS YP_002643353.1 224988666 7561784 complement(334880..337579) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a insertion of 66 bp lead to a longer product than to the homolog Mycobacterium bovis (899 aa versus 877 aa). In Mycobacterium bovis, 2 deletions, one of 18 bp and the other of 66 bp, and part of a 2780 bp insertion , leads to a shorter product with a different 3' end compared to its homolog in Mycobacterium tuberculosis strain H37Rv (877 aa versus 957 aa); PE-PGRS family protein 337579 PE_PGRS3 7561784 PE_PGRS3 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002643353.1 334880 R 561275 CDS YP_002643354.1 224988667 7561771 complement(337829..340333) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, and BCG Tokyo, 2 insertionseach of 9 bp and a deletion of 9 bp, lead to a longer product compared to its homolog in Mycobacterium bovis (834 aa versus 831 aa). In Mycobacterium bovis, 2 deletions each of 9 bp (CCGCCGGCG-* and CCCGCCGGC-*), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (831 aa versus 837 aa); PE-PGRS family protein 340333 PE_PGRS4 7561771 PE_PGRS4 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002643354.1 337829 R 561275 CDS YP_002643355.1 224988668 7561786 340624..342234 1 NC_012207.1 Differs from Rv0280 by 1 aa P337S in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; PPE family protein 342234 PPE3 7561786 PPE3 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002643355.1 340624 D 561275 CDS YP_002643356.1 224988669 7562167 342258..343166 1 NC_012207.1 hypothetical protein 343166 7562167 JTY_0291 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643356.1 342258 D 561275 CDS YP_002643357.1 224988670 7563031 343390..345285 1 NC_012207.1 Differs from Rv0282 by 1aa, A6E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein 345285 7563031 JTY_0292 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643357.1 343390 D 561275 CDS YP_002643358.1 224988671 7563032 345282..346898 1 NC_012207.1 hypothetical protein 346898 7563032 JTY_0293 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643358.1 345282 D 561275 CDS YP_002643359.1 224988672 7563033 346895..350887 1 NC_012207.1 Differs from Mb0292 by 1aa, A134T, and from Rv0284 by 2aa, A134T, R214P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 350887 7563033 JTY_0294 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643359.1 346895 D 561275 CDS YP_002643360.1 224988673 7563034 350884..351192 1 NC_012207.1 PE family protein 351192 PE5 7563034 PE5 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002643360.1 350884 D 561275 CDS YP_002643361.1 224988674 7561736 351195..352736 1 NC_012207.1 PPE family protein 352736 PPE4 7561736 PPE4 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002643361.1 351195 D 561275 CDS YP_002643362.1 224988675 7562178 352785..353078 1 NC_012207.1 hypothetical protein 353078 esxG 7562178 esxG Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643362.1 352785 D 561275 CDS YP_002643363.1 224988676 7562878 353108..353398 1 NC_012207.1 low molecular weight protein antigen 7 353398 esxH 7562878 esxH Mycobacterium bovis BCG str. Tokyo 172 low molecular weight protein antigen 7 YP_002643363.1 353108 D 561275 CDS YP_002643364.1 224988677 7562879 353409..354296 1 NC_012207.1 hypothetical protein 354296 7562879 JTY_0299 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643364.1 353409 D 561275 CDS YP_002643365.1 224988678 7563035 354343..355761 1 NC_012207.1 Differs from Rv0290 by 1aa, T400A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 355761 7563035 JTY_0300 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643365.1 354343 D 561275 CDS YP_002643366.1 224988679 7563036 355758..357143 1 NC_012207.1 protease precursor 357143 7563036 JTY_0301 Mycobacterium bovis BCG str. Tokyo 172 protease precursor YP_002643366.1 355758 D 561275 CDS YP_002643367.1 224988680 7563037 357140..358135 1 NC_012207.1 Differs from Rv0292 by 1aa, D217N in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 358135 7563037 JTY_0302 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643367.1 357140 D 561275 CDS YP_002643368.1 224988681 7563038 complement(358122..359324) 1 NC_012207.1 Differs from Rv0293c and Mb0301c by 1aa, S263G in BCG Pasteur and BCG Tokyo; hypothetical protein 359324 7563038 JTY_0303 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643368.1 358122 R 561275 CDS YP_002643369.1 224988682 7563039 359431..360216 1 NC_012207.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 360216 tam 7563039 tam Mycobacterium bovis BCG str. Tokyo 172 trans-aconitate 2-methyltransferase YP_002643369.1 359431 D 561275 CDS YP_002643370.1 224988683 7561822 complement(360205..361008) 1 NC_012207.1 hypothetical protein 361008 7561822 JTY_0305 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643370.1 360205 R 561275 CDS YP_002643371.1 224988684 7563040 complement(361018..362415) 1 NC_012207.1 sulfatase 362415 7563040 JTY_0306 Mycobacterium bovis BCG str. Tokyo 172 sulfatase YP_002643371.1 361018 R 561275 CDS YP_002643372.1 224988685 7563041 362594..364414 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (606 aa versus 591 aa); PE-PGRS family protein 364414 PE_PGRS5 7563041 PE_PGRS5 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002643372.1 362594 D 561275 CDS YP_002643373.1 224988686 7562375 364557..364784 1 NC_012207.1 hypothetical protein 364784 7562375 JTY_0308 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643373.1 364557 D 561275 CDS YP_002643374.1 224988687 7563042 364781..365083 1 NC_012207.1 Differs from Mb0307 by 1aa, S13N in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 365083 7563042 JTY_0309 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643374.1 364781 D 561275 CDS YP_002643375.1 224988688 7563043 365131..365352 1 NC_012207.1 hypothetical protein 365352 7563043 JTY_0310 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643375.1 365131 D 561275 CDS YP_002643376.1 224988689 7563044 365349..365774 1 NC_012207.1 hypothetical protein 365774 7563044 JTY_0311 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643376.1 365349 D 561275 CDS YP_002643377.1 224988690 7563045 365911..366543 1 NC_012207.1 Differs from Mb0310 by 1aa A124V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably TetR/AcrR-family; transcriptional regulatory protein 366543 7563045 JTY_0312 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643377.1 365911 D 561275 CDS YP_002643378.1 224988691 7563046 366540..367448 1 NC_012207.1 dehydrogenase/reductase 367448 7563046 JTY_0313 Mycobacterium bovis BCG str. Tokyo 172 dehydrogenase/reductase YP_002643378.1 366540 D 561275 CDS YP_002643379.1 224988692 7563047 complement(367456..370899) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (G-*) leads to a shorter CDS (Mycobacterium bovis, BCG Pasteur, and BCG Tokyo) equivalent to the 3' end of Rv0304c/PPE5. Differs from Rv0304c by 3aa, S481G, F708S, A955T, and 5 codon in-frame deletion at position 503 in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; PPE family protein 370899 PPE5 7563047 PPE5 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002643379.1 367456 R 561275 CDS YP_002643380.1 224988693 7562188 complement(371043..376970) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base deletion (T-*) resulting in the absence of a stop codon leads to a longer product. The second part of this CDS shares homology with the 5' end of Rv0304c/PPE5. Differs from Mb0313c by in-frame deletion of 10 codons in BCG Pasteur and BCG Tokyo.; PPE family protein 376970 PPE6 7562188 PPE6 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002643380.1 371043 R 561275 CDS YP_002643381.1 224988694 7561542 377173..377844 1 NC_012207.1 oxidoreductase 377844 7561542 JTY_0316 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002643381.1 377173 D 561275 CDS YP_002643382.1 224988695 7563048 complement(377832..378314) 1 NC_012207.1 hypothetical protein 378314 7563048 JTY_0317 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643382.1 377832 R 561275 CDS YP_002643383.1 224988696 7563049 378372..379088 1 NC_012207.1 integral membrane protein 379088 7563049 JTY_0318 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002643383.1 378372 D 561275 CDS YP_002643384.1 224988697 7563050 379190..379846 1 NC_012207.1 hypothetical protein 379846 7563050 JTY_0319 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643384.1 379190 D 561275 CDS YP_002643385.1 224988698 7563051 complement(379916..380407) 1 NC_012207.1 hypothetical protein 380407 7563051 JTY_0320 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643385.1 379916 R 561275 CDS YP_002643386.1 224988699 7563052 380431..381660 1 NC_012207.1 hypothetical protein 381660 7563052 JTY_0321 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643386.1 380431 D 561275 CDS YP_002643387.1 224988700 7563053 381815..383677 1 NC_012207.1 Differs from Rv0312 by 2aa, G159S, L563P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 383677 7563053 JTY_0322 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643387.1 381815 D 561275 CDS YP_002643388.1 224988701 7563054 383749..384135 1 NC_012207.1 hypothetical protein 384135 7563054 JTY_0323 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643388.1 383749 D 561275 CDS YP_002643389.1 224988702 7563055 complement(384138..384800) 1 NC_012207.1 Differs from Rv0314c by 1aa, A184V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 384800 7563055 JTY_0324 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643389.1 384138 R 561275 CDS YP_002643390.1 224988703 7563056 384861..385745 1 NC_012207.1 Differs from Rv0315 by 1aa, T260K in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; beta-1,3-glucanase precursor 385745 7563056 JTY_0325 Mycobacterium bovis BCG str. Tokyo 172 beta-1,3-glucanase precursor YP_002643390.1 384861 D 561275 CDS YP_002643391.1 224988704 7563057 385794..386408 1 NC_012207.1 muconolactone isomerase 386408 7563057 JTY_0326 Mycobacterium bovis BCG str. Tokyo 172 muconolactone isomerase YP_002643391.1 385794 D 561275 CDS YP_002643392.1 224988705 7563058 complement(386432..387202) 1 NC_012207.1 glycerophosphoryl diester phosphodiesterase 387202 glpQ2 7563058 glpQ2 Mycobacterium bovis BCG str. Tokyo 172 glycerophosphoryl diester phosphodiesterase YP_002643392.1 386432 R 561275 CDS YP_002643393.1 224988706 7563268 complement(387564..388358) 1 NC_012207.1 Differs from Rv0318c by 1aa, A223G in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein 388358 7563268 JTY_0328 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002643393.1 387564 R 561275 CDS YP_002643394.1 224988707 7563059 388407..389075 1 NC_012207.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 389075 pcp 7563059 pcp Mycobacterium bovis BCG str. Tokyo 172 pyrrolidone-carboxylate peptidase YP_002643394.1 388407 D 561275 CDS YP_002643395.1 224988708 7562525 389147..389809 1 NC_012207.1 hypothetical protein 389809 7562525 JTY_0330 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643395.1 389147 D 561275 CDS YP_002643396.1 224988709 7563060 389841..390413 1 NC_012207.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 390413 dcd 7563060 dcd Mycobacterium bovis BCG str. Tokyo 172 deoxycytidine triphosphate deaminase YP_002643396.1 389841 D 561275 CDS YP_002643397.1 224988710 7561470 390519..391850 1 NC_012207.1 UDP-glucose 6-dehydrogenase 391850 udgA 7561470 udgA Mycobacterium bovis BCG str. Tokyo 172 UDP-glucose 6-dehydrogenase YP_002643397.1 390519 D 561275 CDS YP_002643398.1 224988711 7561650 complement(391839..392510) 1 NC_012207.1 Differs from Rv0323c by 1aa, G142S in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein 392510 7561650 JTY_0333 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643398.1 391839 R 561275 CDS YP_002643399.1 224988712 7563061 392611..393291 1 NC_012207.1 Differs from Rv0324 by 1aa, A168T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; possibly ArsR-family; transcriptional regulatory protein 393291 7563061 JTY_0334 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643399.1 392611 D 561275 CDS YP_002643400.1 224988713 7563062 393298..393987 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv0325 and Rv0326 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, the absence of a stop codon between Rv0325 and Rv0326 due to a single base transition (T-C) leads to single product; hypothetical protein 393987 7563062 JTY_0335 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643400.1 393298 D 561275 CDS YP_002643401.1 224988714 7563063 complement(393955..395304) 1 NC_012207.1 Differs from Rv0327c by 1aa, Y100H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; cytochrome P450 135A1 395304 cyp135A1 7563063 cyp135A1 Mycobacterium bovis BCG str. Tokyo 172 cytochrome P450 135A1 YP_002643401.1 393955 R 561275 CDS YP_002643402.1 224988715 7563160 395370..395972 1 NC_012207.1 possibly TetR/AcrR-family; transcriptional regulatory protein 395972 7563160 JTY_0337 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643402.1 395370 D 561275 CDS YP_002643403.1 224988716 7563064 complement(395953..396579) 1 NC_012207.1 Differs from Rv0329c by 1aa, S129W in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 396579 7563064 JTY_0338 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643403.1 395953 R 561275 CDS YP_002643404.1 224988717 7563065 complement(396606..397346) 1 NC_012207.1 hypothetical protein 397346 7563065 JTY_0339 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643404.1 396606 R 561275 CDS YP_002643405.1 224988718 7563066 397460..398626 1 NC_012207.1 dehydrogenase/reductase 398626 7563066 JTY_0340 Mycobacterium bovis BCG str. Tokyo 172 dehydrogenase/reductase YP_002643405.1 397460 D 561275 CDS YP_002643406.1 224988719 7563067 398701..399486 1 NC_012207.1 Differs from Rv0332 by 1aa, G198E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 399486 7563067 JTY_0341 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643406.1 398701 D 561275 CDS YP_002643407.1 224988720 7563068 399513..399887 1 NC_012207.1 hypothetical protein 399887 7563068 JTY_0342 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643407.1 399513 D 561275 CDS YP_002643408.1 224988721 7563069 399917..400783 1 NC_012207.1 glucose-1-phosphate thymidylyltransferase 400783 rmlA 7563069 rmlA Mycobacterium bovis BCG str. Tokyo 172 glucose-1-phosphate thymidylyltransferase YP_002643408.1 399917 D 561275 CDS YP_002643409.1 224988722 7561581 complement(400794..401309) 1 NC_012207.1 Differs from Rv0335c and Mb0340 by 1aa P131T in BCG Pasteur and BCG Tokyo; PE family protein 401309 PE6 7561581 PE6 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002643409.1 400794 R 561275 CDS YP_002643410.1 224988723 7563070 complement(403133..404422) 1 NC_012207.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 404422 aspC 7563070 aspC Mycobacterium bovis BCG str. Tokyo 172 aminotransferase YP_002643410.1 403133 R 561275 CDS YP_002643411.1 224988724 7562044 complement(404453..407101) 1 NC_012207.1 Differs from Rv0338c by 2aa, G506R, V621A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; iron-sulfur-binding reductase 407101 7562044 JTY_0347 Mycobacterium bovis BCG str. Tokyo 172 iron-sulfur-binding reductase YP_002643411.1 404453 R 561275 CDS YP_002643412.1 224988725 7563071 complement(407210..409708) 1 NC_012207.1 transcriptional regulatory protein 409708 7563071 JTY_0348 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643412.1 407210 R 561275 CDS YP_002643413.1 224988726 7563072 409894..410433 1 NC_012207.1 hypothetical protein 410433 7563072 JTY_0349 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643413.1 409894 D 561275 CDS YP_002643414.1 224988727 7563073 410622..412061 1 NC_012207.1 isoniazid inductible gene protein 412061 iniB 7563073 iniB Mycobacterium bovis BCG str. Tokyo 172 isoniazid inductible gene protein YP_002643414.1 410622 D 561275 CDS YP_002643415.1 224988728 7562790 412098..414020 1 NC_012207.1 Differs from by 2aa, S88N, Q481H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; isoniazid inductible gene protein 414020 iniA 7562790 iniA Mycobacterium bovis BCG str. Tokyo 172 isoniazid inductible gene protein YP_002643415.1 412098 D 561275 CDS YP_002643416.1 224988729 7562789 414017..415498 1 NC_012207.1 isoniazid inductible gene protein 415498 iniC 7562789 iniC Mycobacterium bovis BCG str. Tokyo 172 isoniazid inductible gene protein YP_002643416.1 414017 D 561275 CDS YP_002643417.1 224988730 7562791 complement(415641..416201) 1 NC_012207.1 lipoprotein 416201 lpqJ 7562791 lpqJ Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002643417.1 415641 R 561275 CDS YP_002643418.1 224988731 7560502 416310..416720 1 NC_012207.1 In Mycobacterium bovis, a frameshift due to a single base deletion (A-*) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv in Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 416720 7560502 JTY_0354 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643418.1 416310 D 561275 CDS YP_002643419.1 224988732 7563074 complement(416762..418225) 1 NC_012207.1 L-asparagine permease 418225 ansP2 7563074 ansP2 Mycobacterium bovis BCG str. Tokyo 172 L-asparagine permease YP_002643419.1 416762 R 561275 CDS YP_002643420.1 224988733 7563978 418564..419550 1 NC_012207.1 hypothetical protein 419550 7563978 JTY_0356 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643420.1 418564 D 561275 CDS YP_002643421.1 224988734 7563075 419553..420206 1 NC_012207.1 transcriptional regulatory protein 420206 7563075 JTY_0357 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643421.1 419553 D 561275 CDS YP_002643422.1 224988735 7563076 420209..420868 1 NC_012207.1 hypothetical protein 420868 7563076 JTY_0358 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643422.1 420209 D 561275 CDS YP_002643423.1 224988736 7563077 421095..422972 1 NC_012207.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 422972 dnaK 7563077 dnaK Mycobacterium bovis BCG str. Tokyo 172 molecular chaperone DnaK YP_002643423.1 421095 D 561275 CDS YP_002643424.1 224988737 7561506 422969..423676 1 NC_012207.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 423676 grpE 7561506 grpE Mycobacterium bovis BCG str. Tokyo 172 heat shock protein GrpE YP_002643424.1 422969 D 561275 CDS YP_002643425.1 224988738 7563285 423712..424899 1 NC_012207.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 424899 dnaJ1 7563285 dnaJ1 Mycobacterium bovis BCG str. Tokyo 172 molecular chaperone DnaJ YP_002643425.1 423712 D 561275 CDS YP_002643426.1 224988739 7561504 424899..425279 1 NC_012207.1 MerR family; heat shock protein transcriptional regulator 425279 hspR 7561504 hspR Mycobacterium bovis BCG str. Tokyo 172 heat shock protein transcriptional regulator YP_002643426.1 424899 D 561275 CDS YP_002643427.1 224988740 7563329 complement(425302..435825) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PPE7 and PPE8 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 2 bp insertion (*-TA) resulting in the absence of a stop codon between the 2 genes, leads to a single product, and an altered C-terminus; PPE family protein 435825 PPE8 7563329 PPE8 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002643427.1 425302 R 561275 CDS YP_002643428.1 224988741 7560803 complement(435976..436620) 1 NC_012207.1 hypothetical protein 436620 7560803 JTY_0364 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643428.1 435976 R 561275 CDS YP_002643429.1 224988742 7563078 complement(436617..437915) 1 NC_012207.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 437915 purA 7563078 purA Mycobacterium bovis BCG str. Tokyo 172 adenylosuccinate synthetase YP_002643429.1 436617 R 561275 CDS YP_002643430.1 224988743 7560854 438006..438653 1 NC_012207.1 hypothetical protein 438653 7560854 JTY_0366 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643430.1 438006 D 561275 CDS YP_002643431.1 224988744 7563079 438664..439443 1 NC_012207.1 Differs from Rv0359 by 1aa, T252A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein 439443 7563079 JTY_0367 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002643431.1 438664 D 561275 CDS YP_002643432.1 224988745 7563080 complement(439448..439885) 1 NC_012207.1 hypothetical protein 439885 7563080 JTY_0368 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643432.1 439448 R 561275 CDS YP_002643433.1 224988746 7563081 439968..440795 1 NC_012207.1 hypothetical protein 440795 7563081 JTY_0369 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643433.1 439968 D 561275 CDS YP_002643434.1 224988747 7563082 441017..442399 1 NC_012207.1 Differs from Mb0362 by 1aa, V292A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; Mg2+ transport transmembrane protein 442399 mgtE 7563082 mgtE Mycobacterium bovis BCG str. Tokyo 172 Mg2+ transport transmembrane protein YP_002643434.1 441017 D 561275 CDS YP_002643435.1 224988748 7564471 complement(442411..443445) 1 NC_012207.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 443445 fba 7564471 fba Mycobacterium bovis BCG str. Tokyo 172 fructose-bisphosphate aldolase YP_002643435.1 442411 R 561275 CDS YP_002643436.1 224988749 7563396 443541..444224 1 NC_012207.1 Differs from Rv0364 by 1aa, L193I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 444224 7563396 JTY_0372 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643436.1 443541 D 561275 CDS YP_002643437.1 224988750 7563083 complement(444213..445343) 1 NC_012207.1 hypothetical protein 445343 7563083 JTY_0373 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643437.1 444213 R 561275 CDS YP_002643438.1 224988751 7563084 complement(445368..445961) 1 NC_012207.1 hypothetical protein 445961 7563084 JTY_0374 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643438.1 445368 R 561275 CDS YP_002643439.1 224988752 7563085 complement(445990..446379) 1 NC_012207.1 hypothetical protein 446379 7563085 JTY_0375 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643439.1 445990 R 561275 CDS YP_002643440.1 224988753 7563086 complement(446460..447671) 1 NC_012207.1 Differs from Rv0368c by 1aa, H249R, and from Mb0375c by 1aa, G371S in BCG Pasteur and BCG Tokyo; hypothetical protein 447671 7563086 JTY_0376 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643440.1 446460 R 561275 CDS YP_002643441.1 224988754 7563087 complement(447677..448192) 1 NC_012207.1 membrane oxidoreductase 448192 7563087 JTY_0377 Mycobacterium bovis BCG str. Tokyo 172 membrane oxidoreductase YP_002643441.1 447677 R 561275 CDS YP_002643442.1 224988755 7563088 complement(448293..449189) 1 NC_012207.1 Differs from Rv0370c by 1aa, E201G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 449189 7563088 JTY_0378 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002643442.1 448293 R 561275 CDS YP_002643443.1 224988756 7563089 complement(449186..449779) 1 NC_012207.1 hypothetical protein 449779 7563089 JTY_0379 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643443.1 449186 R 561275 CDS YP_002643444.1 224988757 7563090 complement(449776..450531) 1 NC_012207.1 Differs from Mb0379c by 1aa, G161S in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein 450531 7563090 JTY_0380 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643444.1 449776 R 561275 CDS YP_002643445.1 224988758 7563091 complement(450550..452949) 1 NC_012207.1 Differs from Rv0373c by 1aa, S122F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; carbon monoxide dehydrogenase large chain 452949 7563091 JTY_0381 Mycobacterium bovis BCG str. Tokyo 172 carbon monoxide dehydrogenase large chain YP_002643445.1 450550 R 561275 CDS YP_002643446.1 224988759 7563092 complement(452946..453425) 1 NC_012207.1 carbon monoxide dehydrogenase small chain 453425 7563092 JTY_0382 Mycobacterium bovis BCG str. Tokyo 172 carbon monoxide dehydrogenase small chain YP_002643446.1 452946 R 561275 CDS YP_002643447.1 224988760 7563093 complement(453440..454300) 1 NC_012207.1 carbon monoxide dehydrogenase medium chain 454300 7563093 JTY_0383 Mycobacterium bovis BCG str. Tokyo 172 carbon monoxide dehydrogenase medium chain YP_002643447.1 453440 R 561275 CDS YP_002643448.1 224988761 7563094 complement(454376..455518) 1 NC_012207.1 hypothetical protein 455518 7563094 JTY_0384 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643448.1 454376 R 561275 CDS YP_002643449.1 224988762 7563095 455567..456532 1 NC_012207.1 Differs from Rv0377 by 1aa, R302P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably LysR-family; transcriptional regulatory protein 456532 7563095 JTY_0385 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643449.1 455567 D 561275 CDS YP_002643450.1 224988763 7563096 456783..457004 1 NC_012207.1 hypothetical glycine rich protein 457004 7563096 JTY_0386 Mycobacterium bovis BCG str. Tokyo 172 hypothetical glycine rich protein YP_002643450.1 456783 D 561275 CDS YP_002643451.1 224988764 7563097 457123..457338 1 NC_012207.1 protein transport protein 457338 secE2 7563097 secE2 Mycobacterium bovis BCG str. Tokyo 172 protein transport protein YP_002643451.1 457123 D 561275 CDS YP_002643452.1 224988765 7560774 complement(457414..457965) 1 NC_012207.1 RNA methyltransferase 457965 7560774 JTY_0388 Mycobacterium bovis BCG str. Tokyo 172 RNA methyltransferase YP_002643452.1 457414 R 561275 CDS YP_002643453.1 224988766 7563098 complement(458061..458969) 1 NC_012207.1 hypothetical protein 458969 7563098 JTY_0389 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643453.1 458061 R 561275 CDS YP_002643454.1 224988767 7563099 complement(458987..459526) 1 NC_012207.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 459526 pyrE 7563099 pyrE Mycobacterium bovis BCG str. Tokyo 172 orotate phosphoribosyltransferase YP_002643454.1 458987 R 561275 CDS YP_002643455.1 224988768 7560873 complement(459607..460461) 1 NC_012207.1 hypothetical protein 460461 7560873 JTY_0391 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643455.1 459607 R 561275 CDS YP_002643456.1 224988769 7563100 complement(460602..463148) 1 NC_012207.1 endopeptidase ATP binding protein chain b 463148 clpB 7563100 clpB Mycobacterium bovis BCG str. Tokyo 172 endopeptidase ATP binding protein chain b YP_002643456.1 460602 R 561275 CDS YP_002643457.1 224988770 7562107 463281..464453 1 NC_012207.1 monooxygenase 464453 7562107 JTY_0393 Mycobacterium bovis BCG str. Tokyo 172 monooxygenase YP_002643457.1 463281 D 561275 CDS YP_002643458.1 224988771 7563101 464557..467814 1 NC_012207.1 Differs from Mb0393 by 1aa, D902A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably LuxR/UhpA-family; transcriptional regulatory protein 467814 7563101 JTY_0394 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643458.1 464557 D 561275 CDS YP_002643459.1 224988772 7561122 complement(467818..469149) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv0388c and Rv0387c exist as 2 separate genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, 3 different base substitutions, the first of 14 bases, the second of 8 bases (TCTACAGT-GCTACAGG), and lastly of 28 bases, leads to a longer single product. Differs from Mb0394c by 1aa, T361A in BCG Pasteur and BCG Tokyo.; PPE family protein 469149 PPE9 7561122 PPE9 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002643459.1 467818 R 561275 CDS YP_002643460.1 224988773 7560804 469483..470742 1 NC_012207.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 470742 purT 7560804 purT Mycobacterium bovis BCG str. Tokyo 172 phosphoribosylglycinamide formyltransferase 2 YP_002643460.1 469483 D 561275 CDS YP_002643461.1 224988774 7560866 470739..471161 1 NC_012207.1 hypothetical protein 471161 7560866 JTY_0397 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643461.1 470739 D 561275 CDS YP_002643462.1 224988775 7561123 471158..472378 1 NC_012207.1 O-succinylhomoserine sulfhydrylase 472378 metZ 7561123 metZ Mycobacterium bovis BCG str. Tokyo 172 O-succinylhomoserine sulfhydrylase YP_002643462.1 471158 D 561275 CDS YP_002643463.1 224988776 7564468 complement(472375..473787) 1 NC_012207.1 Differs from Rv0392c by 1aa, A241V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; membrane NADH dehydrogenase 473787 ndhA 7564468 ndhA Mycobacterium bovis BCG str. Tokyo 172 membrane NADH dehydrogenase YP_002643463.1 472375 R 561275 CDS YP_002643464.1 224988777 7562457 473929..475254 1 NC_012207.1 conserved 13E12 repeat family protein 475254 7562457 JTY_0400 Mycobacterium bovis BCG str. Tokyo 172 conserved 13E12 repeat family protein YP_002643464.1 473929 D 561275 CDS YP_002643465.1 224988778 7561124 complement(475270..475989) 1 NC_012207.1 hypothetical protein 475989 7561124 JTY_0401 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643465.1 475270 R 561275 CDS YP_002643466.1 224988779 7561125 476088..476492 1 NC_012207.1 Differs from Rv0395 by 1aa, A80V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein 476492 7561125 JTY_0402 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643466.1 476088 D 561275 CDS YP_002643467.1 224988780 7561126 476498..476890 1 NC_012207.1 hypothetical protein 476890 7561126 JTY_0403 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643467.1 476498 D 561275 CDS YP_002643468.1 224988781 7561127 476964..477332 1 NC_012207.1 conserved 13E12 repeat family protein 477332 7561127 JTY_0404 Mycobacterium bovis BCG str. Tokyo 172 conserved 13E12 repeat family protein YP_002643468.1 476964 D 561275 CDS YP_002643469.1 224988782 7561128 complement(477827..478468) 1 NC_012207.1 hypothetical protein 478468 7561128 JTY_0405 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643469.1 477827 R 561275 CDS YP_002643470.1 224988783 7561129 complement(478475..479704) 1 NC_012207.1 lipoprotein 479704 lpqK 7561129 lpqK Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002643470.1 478475 R 561275 CDS YP_002643471.1 224988784 7560503 complement(479714..480901) 1 NC_012207.1 acyl-CoA dehydrogenase 480901 fadE7 7560503 fadE7 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002643471.1 479714 R 561275 CDS YP_002643472.1 224988785 7563390 480937..481308 1 NC_012207.1 transmembrane protein 481308 7563390 JTY_0408 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643472.1 480937 D 561275 CDS YP_002643473.1 224988786 7561130 complement(481503..482606) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (C-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b; transmembrane transport protein 482606 mmpL1b 7561130 mmpL1b Mycobacterium bovis BCG str. Tokyo 172 transmembrane transport protein YP_002643473.1 481503 R 561275 CDS YP_002643474.1 224988787 7564486 complement(482603..484378) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (C-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b. Differs from Rv0402c by 1aa, P451L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane transport protein 484378 mmpL1a 7564486 mmpL1a Mycobacterium bovis BCG str. Tokyo 172 transmembrane transport protein YP_002643474.1 482603 R 561275 CDS YP_002643475.1 224988788 7564485 complement(484375..484803) 1 NC_012207.1 hypothetical protein 484803 mmpS1 7564485 mmpS1 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643475.1 484375 R 561275 CDS YP_002643476.1 224988789 7564496 485124..486881 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 486881 fadD30 7564496 fadD30 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002643476.1 485124 D 561275 CDS YP_002643477.1 224988790 7562936 486878..488260 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to single base insertion (*-G) splits pks6 into 2 parts,pks6a and pks6b; membrane bound polyketide synthase 488260 pks6a 7562936 pks6a Mycobacterium bovis BCG str. Tokyo 172 membrane bound polyketide synthase YP_002643477.1 486878 D 561275 CDS YP_002643478.1 224988791 7562122 488247..491087 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis, a frameshift due to single base insertion (*-G), splits pks6 into 2 parts, pks6a and pks6b. Differs from Mb0413 by 1aa, M921V in BCG Pasteur and BCG Tokyo; membrane bound polyketide synthase 491087 pks6b 7562122 pks6b Mycobacterium bovis BCG str. Tokyo 172 membrane bound polyketide synthase YP_002643478.1 488247 D 561275 CDS YP_002643479.1 224988792 7562123 complement(491035..491853) 1 NC_012207.1 beta lactamase like protein 491853 7562123 JTY_0415 Mycobacterium bovis BCG str. Tokyo 172 beta lactamase like protein YP_002643479.1 491035 R 561275 CDS YP_002643480.1 224988793 7561131 491931..492941 1 NC_012207.1 F420-dependent glucose-6-phosphate dehydrogenase 492941 fgd1 7561131 fgd1 Mycobacterium bovis BCG str. Tokyo 172 F420-dependent glucose-6-phosphate dehydrogenase YP_002643480.1 491931 D 561275 CDS YP_002643481.1 224988794 7563412 492934..495006 1 NC_012207.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 495006 pta 7563412 pta Mycobacterium bovis BCG str. Tokyo 172 phosphate acetyltransferase YP_002643481.1 492934 D 561275 CDS YP_002643482.1 224988795 7560849 494999..496156 1 NC_012207.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 496156 ackA 7560849 ackA Mycobacterium bovis BCG str. Tokyo 172 acetate kinase YP_002643482.1 494999 D 561275 CDS YP_002643483.1 224988796 7563929 complement(496210..498462) 1 NC_012207.1 serine/threonine-protein kinase 498462 pknG 7563929 pknG Mycobacterium bovis BCG str. Tokyo 172 serine/threonine-protein kinase YP_002643483.1 496210 R 561275 CDS YP_002643484.1 224988797 7562434 complement(498462..499448) 1 NC_012207.1 glutamine-binding lipoprotein 499448 glnH 7562434 glnH Mycobacterium bovis BCG str. Tokyo 172 glutamine-binding lipoprotein YP_002643484.1 498462 R 561275 CDS YP_002643485.1 224988798 7561933 complement(499448..500767) 1 NC_012207.1 Differs from Rv0412c by 1aa, Y355D in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 500767 7561933 JTY_0421 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643485.1 499448 R 561275 CDS YP_002643486.1 224988799 7561132 500861..501514 1 NC_012207.1 7,8-dihydro-8-oxoguanine-triphosphatase, 8-oxo-dGTPase, dGTP pyrophosphohydrolase; mutator protein 501514 mutT3 7561132 mutT3 Mycobacterium bovis BCG str. Tokyo 172 mutator protein YP_002643486.1 500861 D 561275 CDS YP_002643487.1 224988800 7563583 complement(501498..502166) 1 NC_012207.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 502166 thiE 7563583 thiE Mycobacterium bovis BCG str. Tokyo 172 thiamine-phosphate pyrophosphorylase YP_002643487.1 501498 R 561275 CDS YP_002643488.1 224988801 7561844 502296..503318 1 NC_012207.1 Differs from Mb0423 by 1aa, A158V in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; thiamine biosynthesis oxidoreductase 503318 thiO 7561844 thiO Mycobacterium bovis BCG str. Tokyo 172 thiamine biosynthesis oxidoreductase YP_002643488.1 502296 D 561275 CDS YP_002643489.1 224988802 7561847 503315..503521 1 NC_012207.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 503521 thiS 7561847 thiS Mycobacterium bovis BCG str. Tokyo 172 sulfur carrier protein ThiS YP_002643489.1 503315 D 561275 CDS YP_002643490.1 224988803 7561848 503514..504272 1 NC_012207.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 504272 thiG 7561848 thiG Mycobacterium bovis BCG str. Tokyo 172 thiazole synthase YP_002643490.1 503514 D 561275 CDS YP_002643491.1 224988804 7561845 504644..506146 1 NC_012207.1 lipoprotein aminopeptidase 506146 lpqL 7561845 lpqL Mycobacterium bovis BCG str. Tokyo 172 lipoprotein aminopeptidase YP_002643491.1 504644 D 561275 CDS YP_002643492.1 224988805 7560504 506234..507730 1 NC_012207.1 Differs from Rv0419 by 2aa, T73A, T297A, and from Mb0427 by 1aa, T73A in BCG Pasteur and BCG Tokyo; lipoprotein peptidase 507730 lpqM 7560504 lpqM Mycobacterium bovis BCG str. Tokyo 172 lipoprotein peptidase YP_002643492.1 506234 D 561275 CDS YP_002643493.1 224988806 7560505 complement(507709..508119) 1 NC_012207.1 Differs from Mb0428c by 1aa, G21E in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; transmembrane protein 508119 7560505 JTY_0429 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643493.1 507709 R 561275 CDS YP_002643494.1 224988807 7561133 complement(508280..508909) 1 NC_012207.1 hypothetical protein 508909 7561133 JTY_0430 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643494.1 508280 R 561275 CDS YP_002643495.1 224988808 7561134 complement(508906..509703) 1 NC_012207.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 509703 thiD 7561134 thiD Mycobacterium bovis BCG str. Tokyo 172 phosphomethylpyrimidine kinase YP_002643495.1 508906 R 561275 CDS YP_002643496.1 224988809 7561843 complement(509730..511373) 1 NC_012207.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 511373 thiC 7561843 thiC Mycobacterium bovis BCG str. Tokyo 172 thiamine biosynthesis protein ThiC YP_002643496.1 509730 R 561275 CDS YP_002643497.1 224988810 7561842 complement(511525..511800) 1 NC_012207.1 hypothetical protein 511800 7561842 JTY_0433 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643497.1 511525 R 561275 CDS YP_002643498.1 224988811 7561135 complement(511850..516469) 1 NC_012207.1 Differs from Rv0425c by 1aa, A222E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; metal cation transporting P-type ATPase 516469 ctpH 7561135 ctpH Mycobacterium bovis BCG str. Tokyo 172 metal cation transporting P-type ATPase YP_002643498.1 511850 R 561275 CDS YP_002643499.1 224988812 7563138 complement(516521..516964) 1 NC_012207.1 transmembrane protein 516964 7563138 JTY_0435 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643499.1 516521 R 561275 CDS YP_002643500.1 224988813 7561136 complement(517165..518040) 1 NC_012207.1 exodeoxyribonuclease III protein 518040 xthA 7561136 xthA Mycobacterium bovis BCG str. Tokyo 172 exodeoxyribonuclease III protein YP_002643500.1 517165 R 561275 CDS YP_002643501.1 224988814 7561700 complement(518043..518951) 1 NC_012207.1 Differs from Rv0428c by 1aa G149D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein 518951 7561700 JTY_0437 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643501.1 518043 R 561275 CDS YP_002643502.1 224988815 7561137 complement(518951..519544) 1 NC_012207.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 519544 def 7561137 def Mycobacterium bovis BCG str. Tokyo 172 peptide deformylase YP_002643502.1 518951 R 561275 CDS YP_002643503.1 224988816 7561475 519881..520189 1 NC_012207.1 hypothetical protein 520189 7561475 JTY_0439 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643503.1 519881 D 561275 CDS YP_002643504.1 224988817 7561138 520221..520715 1 NC_012207.1 Differs from Rv0431 by 2aa, G38V, A87T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; tuberculin related peptide 520715 7561138 JTY_0440 Mycobacterium bovis BCG str. Tokyo 172 tuberculin related peptide YP_002643504.1 520221 D 561275 CDS YP_002643505.1 224988818 7561139 520748..521470 1 NC_012207.1 periplasmic Cu-Zn-superoxide dismutase 521470 sodC 7561139 sodC Mycobacterium bovis BCG str. Tokyo 172 periplasmic Cu-Zn-superoxide dismutase YP_002643505.1 520748 D 561275 CDS YP_002643506.1 224988819 7561803 521472..522602 1 NC_012207.1 ATP-dependent carboxylate-amine ligase; carboxylate-amine ligase 522602 7561803 JTY_0442 Mycobacterium bovis BCG str. Tokyo 172 carboxylate-amine ligase YP_002643506.1 521472 D 561275 CDS YP_002643507.1 224988820 7561140 522662..523315 1 NC_012207.1 Differs from Rv0434 by 1aa, A190T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein 523315 7561140 JTY_0443 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643507.1 522662 D 561275 CDS YP_002643508.1 224988821 7561141 complement(523495..525681) 1 NC_012207.1 ATPase 525681 7561141 JTY_0444 Mycobacterium bovis BCG str. Tokyo 172 ATPase YP_002643508.1 523495 R 561275 CDS YP_002643509.1 224988822 7561142 complement(525678..526538) 1 NC_012207.1 Differs from Rv0436c by 1aa, V167G in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis BCG Pasteur, and BCVG Tokyo; CDP-diacylglycerol--serine O-phosphatidyltransferase 526538 pssA 7561142 pssA Mycobacterium bovis BCG str. Tokyo 172 CDP-diacylglycerol--serine O-phosphatidyltransferase YP_002643509.1 525678 R 561275 CDS YP_002643510.1 224988823 7560839 complement(526535..527230) 1 NC_012207.1 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase 527230 psd 7560839 psd Mycobacterium bovis BCG str. Tokyo 172 phosphatidylserine decarboxylase YP_002643510.1 526535 R 561275 CDS YP_002643511.1 224988824 7560838 complement(527291..528508) 1 NC_012207.1 Differs from Rv0438c by 1aa, I15M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; molybdopterin biosynthesis protein 528508 moeA2 7560838 moeA2 Mycobacterium bovis BCG str. Tokyo 172 molybdopterin biosynthesis protein YP_002643511.1 527291 R 561275 CDS YP_002643512.1 224988825 7563540 complement(528527..529462) 1 NC_012207.1 short chain dehydrogenase 529462 7563540 JTY_0448 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002643512.1 528527 R 561275 CDS YP_002643513.1 224988826 7561143 529756..531378 1 NC_012207.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 531378 groEL 7561143 groEL Mycobacterium bovis BCG str. Tokyo 172 molecular chaperone GroEL YP_002643513.1 529756 D 561275 CDS YP_002643514.1 224988827 7563282 complement(531444..531872) 1 NC_012207.1 hypothetical protein 531872 7563282 JTY_0450 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643514.1 531444 R 561275 CDS YP_002643515.1 224988828 7561144 complement(531899..533338) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (G-A) creates an in-frame stop at codon 8, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (479 aa versus 487 aa). Differs from Mb0450c by 1aa, T214K, and from Rv0442c by 2aa, E23K, T214K in BCG Pasteur and BCG Tokyo.; PPE family protein 533338 PPE10 7561144 PPE10 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002643515.1 531899 R 561275 CDS YP_002643516.1 224988829 7562145 533544..534059 1 NC_012207.1 hypothetical protein 534059 7562145 JTY_0452 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643516.1 533544 D 561275 CDS YP_002643517.1 224988830 7561145 complement(534239..534937) 1 NC_012207.1 Differs from Rv0444c by 2aa, D107G, E184G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein 534937 7561145 JTY_0453 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643517.1 534239 R 561275 CDS YP_002643518.1 224988831 7561146 complement(534981..535544) 1 NC_012207.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins; RNA polymerase sigma factor SigK 535544 sigK 7561146 sigK Mycobacterium bovis BCG str. Tokyo 172 RNA polymerase sigma factor SigK YP_002643518.1 534981 R 561275 CDS YP_002643519.1 224988832 7561795 complement(535593..536363) 1 NC_012207.1 transmembrane protein 536363 7561795 JTY_0455 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643519.1 535593 R 561275 CDS YP_002643520.1 224988833 7561147 complement(536372..537655) 1 NC_012207.1 cyclopropane-fatty-acyl-phospholipid synthase 537655 ufaA1 7561147 ufaA1 Mycobacterium bovis BCG str. Tokyo 172 cyclopropane-fatty-acyl-phospholipid synthase YP_002643520.1 536372 R 561275 CDS YP_002643521.1 224988834 7561651 complement(537652..538317) 1 NC_012207.1 hypothetical protein 538317 7561651 JTY_0457 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643521.1 537652 R 561275 CDS YP_002643522.1 224988835 7561148 complement(538377..539696) 1 NC_012207.1 hypothetical protein 539696 7561148 JTY_0458 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643522.1 538377 R 561275 CDS YP_002643523.1 224988836 7561149 complement(539736..542639) 1 NC_012207.1 Differs from Mb0458c by 1aa, A314T in BCG Pasteur and BCG Tokyo; transmembrane transport protein 542639 mmpL4 7561149 mmpL4 Mycobacterium bovis BCG str. Tokyo 172 transmembrane transport protein YP_002643523.1 539736 R 561275 CDS YP_002643524.1 224988837 7564489 complement(542636..543058) 1 NC_012207.1 hypothetical protein 543058 mmpS4 7564489 mmpS4 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643524.1 542636 R 561275 CDS YP_002643525.1 224988838 7563514 543290..544000 1 NC_012207.1 transcriptional regulatory protein 544000 7563514 JTY_0461 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643525.1 543290 D 561275 CDS YP_002643526.1 224988839 7561150 544322..545878 1 NC_012207.1 PPE family protein 545878 PPE11 7561150 PPE11 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002643526.1 544322 D 561275 CDS YP_002643527.1 224988840 7562146 545983..546333 1 NC_012207.1 hypothetical protein 546333 7562146 JTY_0463 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643527.1 545983 D 561275 CDS YP_002643528.1 224988841 7561151 complement(546523..546969) 1 NC_012207.1 hypothetical protein 546969 7561151 JTY_0464 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643528.1 546523 R 561275 CDS YP_002643529.1 224988842 7561152 complement(547037..547951) 1 NC_012207.1 catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 547951 echA2 7561152 echA2 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002643529.1 547037 R 561275 CDS YP_002643530.1 224988843 7561531 complement(548224..548505) 1 NC_012207.1 hypothetical protein 548505 7561531 JTY_0466 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643530.1 548224 R 561275 CDS YP_002643531.1 224988844 7561153 complement(548734..550764) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a possible RBS upstream leads to an earlier start resulting in a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (676 aa versus 673 aa); peptidase 550764 7561153 JTY_0467 Mycobacterium bovis BCG str. Tokyo 172 peptidase YP_002643531.1 548734 R 561275 CDS YP_002643532.1 224988845 7561154 550823..552346 1 NC_012207.1 aldehyde dehydrogenase 552346 7561154 JTY_0468 Mycobacterium bovis BCG str. Tokyo 172 aldehyde dehydrogenase YP_002643532.1 550823 D 561275 CDS YP_002643533.1 224988846 7561155 552346..552837 1 NC_012207.1 hypothetical protein 552837 7561155 JTY_0469 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643533.1 552346 D 561275 CDS YP_002643534.1 224988847 7561156 552897..553136 1 NC_012207.1 conserved hydrophobic protein 553136 7561156 JTY_0470 Mycobacterium bovis BCG str. Tokyo 172 conserved hydrophobic protein YP_002643534.1 552897 D 561275 CDS YP_002643535.1 224988848 7561157 553174..553698 1 NC_012207.1 transmembrane protein 553698 7561157 JTY_0471 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643535.1 553174 D 561275 CDS YP_002643536.1 224988849 7561158 553762..555156 1 NC_012207.1 E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; dihydrolipoamide dehydrogenase 555156 lpd 7561158 lpd Mycobacterium bovis BCG str. Tokyo 172 dihydrolipoamide dehydrogenase YP_002643536.1 553762 D 561275 CDS YP_002643537.1 224988850 7562852 555164..555457 1 NC_012207.1 hypothetical protein 555457 7562852 JTY_0473 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643537.1 555164 D 561275 CDS YP_002643538.1 224988851 7561159 complement(555461..556033) 1 NC_012207.1 hypothetical protein 556033 7561159 JTY_0474 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643538.1 555461 R 561275 CDS YP_002643539.1 224988852 7561160 complement(556030..557454) 1 NC_012207.1 Differs from Rv0465c by 2aa, D36N, R106C, and from Mb0474c by 1aa, R326Q in BCG Pasteur and BCG Tokyo; transcriptional regulatory protein 557454 7561160 JTY_0475 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643539.1 556030 R 561275 CDS YP_002643540.1 224988853 7561161 557606..558400 1 NC_012207.1 hypothetical protein 558400 7561161 JTY_0476 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643540.1 557606 D 561275 CDS YP_002643541.1 224988854 7561162 558675..559961 1 NC_012207.1 isocitrate lyase 559961 icl 7561162 icl Mycobacterium bovis BCG str. Tokyo 172 isocitrate lyase YP_002643541.1 558675 D 561275 CDS YP_002643542.1 224988855 7563341 560043..560903 1 NC_012207.1 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase 560903 fadB2 7563341 fadB2 Mycobacterium bovis BCG str. Tokyo 172 3-hydroxybutyryl-CoA dehydrogenase YP_002643542.1 560043 D 561275 CDS YP_002643543.1 224988856 7562911 561036..561896 1 NC_012207.1 mycolic acid synthase 561896 umaA1 7562911 umaA1 Mycobacterium bovis BCG str. Tokyo 172 mycolic acid synthase YP_002643543.1 561036 D 561275 CDS YP_002643544.1 224988857 7561657 complement(561996..562859) 1 NC_012207.1 Differs from Rv0470c, Mb0479c by 1aa, P154T in Mycobacterium bovis BCG Tokyo.; mycolic acid synthase 562859 pcaA 7561657 pcaA Mycobacterium bovis BCG str. Tokyo 172 mycolic acid synthase YP_002643544.1 561996 R 561275 CDS YP_002643545.1 224988858 7562521 complement(563002..563442) 1 NC_012207.1 hypothetical protein 563442 7562521 JTY_0481 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643545.1 563002 R 561275 CDS YP_002643546.1 224988859 7561163 complement(563373..563861) 1 NC_012207.1 hypothetical protein 563861 7561163 JTY_0482 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643546.1 563373 R 561275 CDS YP_002643547.1 224988860 7561164 complement(563871..564575) 1 NC_012207.1 Differs from Rv0472c and Mb0482c by 1aa, D162G in BCG Pasteur and BCG Tokyo; possibly TetR-family; transcriptional regulatory protein 564575 7561164 JTY_0483 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643547.1 563871 R 561275 CDS YP_002643548.1 224988861 7561165 564712..566082 1 NC_012207.1 Differs from Rv0473 by 1aa, R5K in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 566082 7561165 JTY_0484 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643548.1 564712 D 561275 CDS YP_002643549.1 224988862 7561166 566169..566591 1 NC_012207.1 transcriptional regulatory protein 566591 7561166 JTY_0485 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643549.1 566169 D 561275 CDS YP_002643550.1 224988863 7561167 566945..567544 1 NC_012207.1 heparin binding hemagglutinin 567544 hbhA 7561167 hbhA Mycobacterium bovis BCG str. Tokyo 172 heparin binding hemagglutinin YP_002643550.1 566945 D 561275 CDS YP_002643551.1 224988864 7563294 567656..567919 1 NC_012207.1 transmembrane protein 567919 7563294 JTY_0487 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643551.1 567656 D 561275 CDS YP_002643552.1 224988865 7561168 567924..568370 1 NC_012207.1 hypothetical protein 568370 7561168 JTY_0488 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643552.1 567924 D 561275 CDS YP_002643553.1 224988866 7561169 568370..569044 1 NC_012207.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 569044 deoC 7561169 deoC Mycobacterium bovis BCG str. Tokyo 172 deoxyribose-phosphate aldolase YP_002643553.1 568370 D 561275 CDS YP_002643554.1 224988867 7561479 complement(569069..570115) 1 NC_012207.1 hypothetical protein 570115 7561479 JTY_0490 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643554.1 569069 R 561275 CDS YP_002643555.1 224988868 7561170 complement(570112..571047) 1 NC_012207.1 In Mycobacterium bovis, a 56 bp deletion results in a different NH2 part and leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (311 aa versus 340 aa); hypothetical protein 571047 7561170 JTY_0491 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643555.1 570112 R 561275 CDS YP_002643556.1 224988869 7561171 complement(571080..571604) 1 NC_012207.1 hypothetical protein 571604 7561171 JTY_0492 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643556.1 571080 R 561275 CDS YP_002643557.1 224988870 7561172 571631..572740 1 NC_012207.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 572740 murB 7561172 murB Mycobacterium bovis BCG str. Tokyo 172 UDP-N-acetylenolpyruvoylglucosamine reductase YP_002643557.1 571631 D 561275 CDS YP_002643558.1 224988871 7563572 572802..574157 1 NC_012207.1 lipoprotein 574157 lprQ 7563572 lprQ Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002643558.1 572802 D 561275 CDS YP_002643559.1 224988872 7560534 complement(574138..574893) 1 NC_012207.1 Differs from Rv0484c by 1aa, L140I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; short-chain type oxidoreductase 574893 7560534 JTY_0495 Mycobacterium bovis BCG str. Tokyo 172 short-chain type oxidoreductase YP_002643559.1 574138 R 561275 CDS YP_002643560.1 224988873 7561173 575076..576392 1 NC_012207.1 transcriptional regulatory protein 576392 7561173 JTY_0496 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643560.1 575076 D 561275 CDS YP_002643561.1 224988874 7561174 576440..577882 1 NC_012207.1 mannosyltransferase 577882 7561174 JTY_0497 Mycobacterium bovis BCG str. Tokyo 172 mannosyltransferase YP_002643561.1 576440 D 561275 CDS YP_002643562.1 224988875 7561175 577879..578430 1 NC_012207.1 hypothetical protein 578430 7561175 JTY_0498 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643562.1 577879 D 561275 CDS YP_002643563.1 224988876 7561176 578814..579419 1 NC_012207.1 integral membrane protein 579419 7561176 JTY_0499 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002643563.1 578814 D 561275 CDS YP_002643564.1 224988877 7561177 579576..580325 1 NC_012207.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 580325 gpmA 7561177 gpmA Mycobacterium bovis BCG str. Tokyo 172 phosphoglyceromutase YP_002643564.1 579576 D 561275 CDS YP_002643565.1 224988878 7563275 580499..581731 1 NC_012207.1 Differs from Rv0490 and Mb0500 by 1aa, S109F; two component sensor histidine kinase 581731 senX3 7563275 senX3 Mycobacterium bovis BCG str. Tokyo 172 two component sensor histidine kinase YP_002643565.1 580499 D 561275 CDS YP_002643566.1 224988879 7560778 581959..582642 1 NC_012207.1 Differs from Rv0491 and Mb0501 by 1aa, T18A in BCG Pasteur, by 2aa, T18A, C219R in BCG Tokyo.; probably LuxR-family; two component sensory transduction protein 582642 regX3 7560778 regX3 Mycobacterium bovis BCG str. Tokyo 172 two component sensory transduction protein YP_002643566.1 581959 D 561275 CDS YP_002643567.1 224988880 7561564 complement(582639..584528) 1 NC_012207.1 Differs from Rv0492c by 1aa, F520L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase GMC-type 584528 7561564 JTY_0503 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase GMC-type YP_002643567.1 582639 R 561275 CDS YP_002643568.1 224988881 7561178 complement(584525..584854) 1 NC_012207.1 hypothetical protein 584854 7561178 JTY_0504 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643568.1 584525 R 561275 CDS YP_002643569.1 224988882 7561179 complement(584851..585840) 1 NC_012207.1 Differs from Rv0493c by 1aa, G174S in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 585840 7561179 JTY_0505 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643569.1 584851 R 561275 CDS YP_002643570.1 224988883 7561180 585845..586573 1 NC_012207.1 probably GntR-family; transcriptional regulatory protein 586573 7561180 JTY_0506 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643570.1 585845 D 561275 CDS YP_002643571.1 224988884 7561181 complement(586574..587464) 1 NC_012207.1 hypothetical protein 587464 7561181 JTY_0507 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643571.1 586574 R 561275 CDS YP_002643572.1 224988885 7561182 587544..588530 1 NC_012207.1 hypothetical protein 588530 7561182 JTY_0508 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643572.1 587544 D 561275 CDS YP_002643573.1 224988886 7561183 588527..589459 1 NC_012207.1 transmembrane protein 589459 7561183 JTY_0509 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643573.1 588527 D 561275 CDS YP_002643574.1 224988887 7561184 589475..590317 1 NC_012207.1 hypothetical protein 590317 7561184 JTY_0510 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643574.1 589475 D 561275 CDS YP_002643575.1 224988888 7561185 590333..591208 1 NC_012207.1 hypothetical protein 591208 7561185 JTY_0511 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643575.1 590333 D 561275 CDS YP_002643576.1 224988889 7561186 591233..592120 1 NC_012207.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 592120 proC 7561186 proC Mycobacterium bovis BCG str. Tokyo 172 pyrroline-5-carboxylate reductase YP_002643576.1 591233 D 561275 CDS YP_002643577.1 224988890 7560826 592261..592497 1 NC_012207.1 hypothetical protein 592497 7560826 JTY_0513 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643577.1 592261 D 561275 CDS YP_002643578.1 224988891 7561187 592804..593934 1 NC_012207.1 UDP-glucose 4-epimerase 593934 galE2 7561187 galE2 Mycobacterium bovis BCG str. Tokyo 172 UDP-glucose 4-epimerase YP_002643578.1 592804 D 561275 CDS YP_002643579.1 224988892 7561897 593941..595017 1 NC_012207.1 hypothetical protein 595017 7561897 JTY_0515 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643579.1 593941 D 561275 CDS YP_002643580.1 224988893 7561188 complement(595021..595929) 1 NC_012207.1 cyclopropane-fatty-acyl-phospholipid synthase 2 595929 cmaA2 7561188 cmaA2 Mycobacterium bovis BCG str. Tokyo 172 cyclopropane-fatty-acyl-phospholipid synthase 2 YP_002643580.1 595021 R 561275 CDS YP_002643581.1 224988894 7562115 complement(595952..596452) 1 NC_012207.1 hypothetical protein 596452 7562115 JTY_0517 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643581.1 595952 R 561275 CDS YP_002643582.1 224988895 7561189 complement(596614..597735) 1 NC_012207.1 phosphoserine phosphatase 597735 serB1 7561189 serB1 Mycobacterium bovis BCG str. Tokyo 172 phosphoserine phosphatase YP_002643582.1 596614 R 561275 CDS YP_002643583.1 224988896 7560781 597909..598352 1 NC_012207.1 hypothetical protein 598352 mmpS2 7560781 mmpS2 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643583.1 597909 D 561275 CDS YP_002643584.1 224988897 7563512 598349..601255 1 NC_012207.1 Differs from Mb0519 by 1aa, D119H, and from Rv0507 by 3aa, H426R, Y509D, C722S in BCG Pasteur and BCG Tokyo; transmembrane transport protein 601255 mmpL2 7563512 mmpL2 Mycobacterium bovis BCG str. Tokyo 172 transmembrane transport protein YP_002643584.1 598349 D 561275 CDS YP_002643585.1 224988898 7564487 601248..601541 1 NC_012207.1 hypothetical protein 601541 7564487 JTY_0521 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643585.1 601248 D 561275 CDS YP_002643586.1 224988899 7561190 601591..602997 1 NC_012207.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 602997 hemA 7561190 hemA Mycobacterium bovis BCG str. Tokyo 172 glutamyl-tRNA reductase YP_002643586.1 601591 D 561275 CDS YP_002643587.1 224988900 7563297 603007..603936 1 NC_012207.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 603936 hemC 7563297 hemC Mycobacterium bovis BCG str. Tokyo 172 porphobilinogen deaminase YP_002643587.1 603007 D 561275 CDS YP_002643588.1 224988901 7563299 603969..605666 1 NC_012207.1 uroporphyrin-III C-methyltransferase 605666 hemD 7563299 hemD Mycobacterium bovis BCG str. Tokyo 172 uroporphyrin-III C-methyltransferase YP_002643588.1 603969 D 561275 CDS YP_002643589.1 224988902 7563300 605752..606741 1 NC_012207.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 606741 hemB 7563300 hemB Mycobacterium bovis BCG str. Tokyo 172 delta-aminolevulinic acid dehydratase YP_002643589.1 605752 D 561275 CDS YP_002643590.1 224988903 7563298 606754..607302 1 NC_012207.1 transmembrane protein 607302 7563298 JTY_0526 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643590.1 606754 D 561275 CDS YP_002643591.1 224988904 7561191 607299..607598 1 NC_012207.1 Differs from Mb0527 and Rv0514 by 1aa, G23A in BCG Pasteur and BCG Tokyo; transmembrane protein 607598 7561191 JTY_0527 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643591.1 607299 D 561275 CDS YP_002643592.1 224988905 7561192 607701..609212 1 NC_012207.1 conserved 13E12 repeat family protein 609212 7561192 JTY_0528 Mycobacterium bovis BCG str. Tokyo 172 conserved 13E12 repeat family protein YP_002643592.1 607701 D 561275 CDS YP_002643593.1 224988906 7561193 complement(609209..609685) 1 NC_012207.1 hypothetical protein 609685 7561193 JTY_0529 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643593.1 609209 R 561275 CDS YP_002643594.1 224988907 7561194 609896..611206 1 NC_012207.1 Differs from Rv0517 by 1aa, G394D in BCG Pasteur and BCG Tokyo; membrane acyltransferase 611206 7561194 JTY_0530 Mycobacterium bovis BCG str. Tokyo 172 membrane acyltransferase YP_002643594.1 609896 D 561275 CDS YP_002643595.1 224988908 7561195 611338..612033 1 NC_012207.1 hypothetical protein 612033 7561195 JTY_0531 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643595.1 611338 D 561275 CDS YP_002643596.1 224988909 7561196 complement(612322..613224) 1 NC_012207.1 hypothetical protein 613224 7561196 JTY_0532 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643596.1 612322 R 561275 CDS YP_002643597.1 224988910 7561197 613405..613755 1 NC_012207.1 methyltransferase/methylase 613755 7561197 JTY_0533 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase/methylase YP_002643597.1 613405 D 561275 CDS YP_002643598.1 224988911 7561198 613748..614053 1 NC_012207.1 methyltransferase/methylase 614053 7561198 JTY_0534 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase/methylase YP_002643598.1 613748 D 561275 CDS YP_002643599.1 224988912 7561199 614188..615492 1 NC_012207.1 4-amino butyrate transport carrier; GabA permease 615492 gabP 7561199 gabP Mycobacterium bovis BCG str. Tokyo 172 GabA permease YP_002643599.1 614188 D 561275 CDS YP_002643600.1 224988913 7561893 complement(615476..615871) 1 NC_012207.1 hypothetical protein 615871 7561893 JTY_0536 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643600.1 615476 R 561275 CDS YP_002643601.1 224988914 7561200 615985..617373 1 NC_012207.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 617373 hemL 7561200 hemL Mycobacterium bovis BCG str. Tokyo 172 glutamate-1-semialdehyde aminotransferase YP_002643601.1 615985 D 561275 CDS YP_002643602.1 224988915 7563303 617373..617981 1 NC_012207.1 hypothetical protein 617981 7563303 JTY_0538 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643602.1 617373 D 561275 CDS YP_002643603.1 224988916 7561201 617996..618646 1 NC_012207.1 thioredoxin protein 618646 7561201 JTY_0539 Mycobacterium bovis BCG str. Tokyo 172 thioredoxin protein YP_002643603.1 617996 D 561275 CDS YP_002643604.1 224988917 7561202 618643..619422 1 NC_012207.1 cytochrome c-type biogenesis protein 619422 ccdA 7561202 ccdA Mycobacterium bovis BCG str. Tokyo 172 cytochrome c-type biogenesis protein YP_002643604.1 618643 D 561275 CDS YP_002643605.1 224988918 7562085 619455..621044 1 NC_012207.1 transmembrane protein 621044 7562085 JTY_0541 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643605.1 619455 D 561275 CDS YP_002643606.1 224988919 7561203 621041..622015 1 NC_012207.1 cytochrome c-type biogenesis protein 622015 ccsA 7561203 ccsA Mycobacterium bovis BCG str. Tokyo 172 cytochrome c-type biogenesis protein YP_002643606.1 621041 D 561275 CDS YP_002643607.1 224988920 7562086 622057..623274 1 NC_012207.1 hypothetical protein 623274 7562086 JTY_0543 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643607.1 622057 D 561275 CDS YP_002643608.1 224988921 7564086 623479..623796 1 NC_012207.1 hypothetical protein 623796 7564086 JTY_0544 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643608.1 623479 D 561275 CDS YP_002643609.1 224988922 7564087 623943..625688 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS6 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-T) splits PE_PGRS6 into 2 parts, PE_PGRS6a and PE_PGRS6b, resulting in PE_PGRS6a having a different COOH part. There is also a 84 bp and a 9 bp (*-cggggccgg) insertion in PE_PGRS6a; PE-PGRS family protein 625688 PE_PGRS6a 7564087 PE_PGRS6a Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002643609.1 623943 D 561275 CDS YP_002643610.1 224988923 7562391 complement(625717..626724) 1 NC_012207.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 626724 fabH 7562391 fabH Mycobacterium bovis BCG str. Tokyo 172 3-oxoacyl-ACP synthase YP_002643610.1 625717 R 561275 CDS YP_002643611.1 224988924 7562903 complement(626806..627684) 1 NC_012207.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 627684 menA 7562903 menA Mycobacterium bovis BCG str. Tokyo 172 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_002643611.1 626806 R 561275 CDS YP_002643612.1 224988925 7564449 627701..628495 1 NC_012207.1 Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate; 5'-methylthioadenosine phosphorylase 628495 pnp 7564449 pnp Mycobacterium bovis BCG str. Tokyo 172 5'-methylthioadenosine phosphorylase YP_002643612.1 627701 D 561275 CDS YP_002643613.1 224988926 7562135 628492..629532 1 NC_012207.1 UDP-glucose 4-epimerase 629532 galE3 7562135 galE3 Mycobacterium bovis BCG str. Tokyo 172 UDP-glucose 4-epimerase YP_002643613.1 628492 D 561275 CDS YP_002643614.1 224988927 7561898 complement(629542..630975) 1 NC_012207.1 integral membrane protein 630975 7561898 JTY_0551 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002643614.1 629542 R 561275 CDS YP_002643615.1 224988928 7564088 631284..632930 1 NC_012207.1 Differs from Rv0538 by 1aa, P228R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 632930 7564088 JTY_0552 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643615.1 631284 D 561275 CDS YP_002643616.1 224988929 7564089 632987..633619 1 NC_012207.1 dolichyl-phosphate sugar synthase 633619 7564089 JTY_0553 Mycobacterium bovis BCG str. Tokyo 172 dolichyl-phosphate sugar synthase YP_002643616.1 632987 D 561275 CDS YP_002643617.1 224988930 7564090 633616..634278 1 NC_012207.1 hypothetical protein 634278 7564090 JTY_0554 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643617.1 633616 D 561275 CDS YP_002643618.1 224988931 7564091 complement(634299..635648) 1 NC_012207.1 Differs from Rv0541c by 1aa, V226I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein 635648 7564091 JTY_0555 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002643618.1 634299 R 561275 CDS YP_002643619.1 224988932 7564092 complement(635660..636748) 1 NC_012207.1 O-succinylbenzoic acid--CoA ligase 636748 menE 7564092 menE Mycobacterium bovis BCG str. Tokyo 172 O-succinylbenzoic acid--CoA ligase YP_002643619.1 635660 R 561275 CDS YP_002643620.1 224988933 7564453 complement(636817..637119) 1 NC_012207.1 hypothetical protein 637119 7564453 JTY_0557 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643620.1 636817 R 561275 CDS YP_002643621.1 224988934 7564093 complement(637179..637457) 1 NC_012207.1 transmembrane protein 637457 7564093 JTY_0558 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643621.1 637179 R 561275 CDS YP_002643622.1 224988935 7564094 complement(637454..638707) 1 NC_012207.1 Differs from Rv0545c by 1aa, S49P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; low-affinity inorganic phosphate transporter integral membrane protein 638707 pitA 7564094 pitA Mycobacterium bovis BCG str. Tokyo 172 low-affinity inorganic phosphate transporter integral membrane protein YP_002643622.1 637454 R 561275 CDS YP_002643623.1 224988936 7562426 complement(638827..639213) 1 NC_012207.1 hypothetical protein 639213 7562426 JTY_0560 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643623.1 638827 R 561275 CDS YP_002643624.1 224988937 7564095 complement(639276..640160) 1 NC_012207.1 short chain dehydrogenase 640160 7564095 JTY_0561 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002643624.1 639276 R 561275 CDS YP_002643625.1 224988938 7564096 complement(640256..641200) 1 NC_012207.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 641200 menB 7564096 menB Mycobacterium bovis BCG str. Tokyo 172 naphthoate synthase YP_002643625.1 640256 R 561275 CDS YP_002643626.1 224988939 7564097 complement(641576..641884) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv0549c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (T-*), splits Rv0549c into 2 parts; hypothetical protein 641884 7564097 JTY_0564 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643626.1 641576 R 561275 CDS YP_002643627.1 224988940 7564098 complement(641881..642147) 1 NC_012207.1 hypothetical protein 642147 7564098 JTY_0565 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643627.1 641881 R 561275 CDS YP_002643628.1 224988941 7564099 complement(642339..644054) 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 644054 fadD8 7564099 fadD8 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002643628.1 642339 R 561275 CDS YP_002643629.1 224988942 7563356 644132..645736 1 NC_012207.1 Differs from Rv0552 and Mb0567 by 1aa, T144I in Mycobacterium bovis BCG Pasteur; hypothetical protein 645736 7563356 JTY_0567 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643629.1 644132 D 561275 CDS YP_002643630.1 224988943 7564100 645733..646713 1 NC_012207.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 646713 menC 7564100 menC Mycobacterium bovis BCG str. Tokyo 172 O-succinylbenzoate synthase YP_002643630.1 645733 D 561275 CDS YP_002643631.1 224988944 7564451 646710..647498 1 NC_012207.1 non-haem peroxidase; peroxidase 647498 bpoC 7564451 bpoC Mycobacterium bovis BCG str. Tokyo 172 peroxidase YP_002643631.1 646710 D 561275 CDS YP_002643632.1 224988945 7562078 647541..649205 1 NC_012207.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 649205 menD 7562078 menD Mycobacterium bovis BCG str. Tokyo 172 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_002643632.1 647541 D 561275 CDS YP_002643633.1 224988946 7564452 649202..649717 1 NC_012207.1 Differs from Rv0556 by 1aa, R15L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 649717 7564452 JTY_0571 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643633.1 649202 D 561275 CDS YP_002643634.1 224988947 7564101 649779..650915 1 NC_012207.1 mannosyltransferase 650915 pimB 7564101 pimB Mycobacterium bovis BCG str. Tokyo 172 mannosyltransferase YP_002643634.1 649779 D 561275 CDS YP_002643635.1 224988948 7562422 650932..651636 1 NC_012207.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 651636 ubiE 7562422 ubiE Mycobacterium bovis BCG str. Tokyo 172 ubiquinone/menaquinone biosynthesis methyltransferase YP_002643635.1 650932 D 561275 CDS YP_002643636.1 224988949 7561649 complement(651650..651988) 1 NC_012207.1 hypothetical protein 651988 7561649 JTY_0574 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643636.1 651650 R 561275 CDS YP_002643637.1 224988950 7564102 complement(652022..652747) 1 NC_012207.1 benzoquinone methyltransferase 652747 7564102 JTY_0575 Mycobacterium bovis BCG str. Tokyo 172 benzoquinone methyltransferase YP_002643637.1 652022 R 561275 CDS YP_002643638.1 224988951 7564103 complement(652772..653998) 1 NC_012207.1 oxidoreductase 653998 7564103 JTY_0576 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002643638.1 652772 R 561275 CDS YP_002643639.1 224988952 7564104 654014..655021 1 NC_012207.1 polyprenyl-diphosphate synthase 655021 grcC1 7564104 grcC1 Mycobacterium bovis BCG str. Tokyo 172 polyprenyl-diphosphate synthase YP_002643639.1 654014 D 561275 CDS YP_002643640.1 224988953 7563279 655122..655982 1 NC_012207.1 metalloprotease; heat shock protein HtpX 655982 htpX 7563279 htpX Mycobacterium bovis BCG str. Tokyo 172 heat shock protein HtpX YP_002643640.1 655122 D 561275 CDS YP_002643641.1 224988954 7563332 complement(656167..657192) 1 NC_012207.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 657192 gpdA1 7563332 gpdA1 Mycobacterium bovis BCG str. Tokyo 172 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_002643641.1 656167 R 561275 CDS YP_002643642.1 224988955 7563274 complement(657253..658713) 1 NC_012207.1 monooxygenase 658713 7563274 JTY_0580 Mycobacterium bovis BCG str. Tokyo 172 monooxygenase YP_002643642.1 657253 R 561275 CDS YP_002643643.1 224988956 7564105 complement(658791..659282) 1 NC_012207.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 659282 7564105 JTY_0581 Mycobacterium bovis BCG str. Tokyo 172 nucleotide-binding protein YP_002643643.1 658791 R 561275 CDS YP_002643644.1 224988957 7561648 659564..660583 1 NC_012207.1 Differs from Rv0567 by 1aa, L201F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methyltransferase/methylase 660583 7561648 JTY_0582 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase/methylase YP_002643644.1 659564 D 561275 CDS YP_002643645.1 224988958 7564107 660693..662111 1 NC_012207.1 Differs from Rv0568 and Mb0583 by 1aa, E120G in BCG Pasteur and BCG Tokyo; cytochrome p450 135b1 662111 cyp135B1 7564107 cyp135B1 Mycobacterium bovis BCG str. Tokyo 172 cytochrome p450 135b1 YP_002643645.1 660693 D 561275 CDS YP_002643646.1 224988959 7563161 662246..662512 1 NC_012207.1 hypothetical protein 662512 7563161 JTY_0584 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643646.1 662246 D 561275 CDS YP_002643647.1 224988960 7564108 662538..664670 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (C-*) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; ribonucleoside-diphosphate reductase large subunit 664670 nrdZ 7564108 nrdZ Mycobacterium bovis BCG str. Tokyo 172 ribonucleoside-diphosphate reductase large subunit YP_002643647.1 662538 D 561275 CDS YP_002643648.1 224988961 7562470 complement(664729..666060) 1 NC_012207.1 Differs from Rv0571c and Mb0586c by 1aa, L258F in BCG Pasteur and BCG Tokyo; hypothetical protein 666060 7562470 JTY_0586 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643648.1 664729 R 561275 CDS YP_002643649.1 224988962 7564109 complement(666284..666625) 1 NC_012207.1 Differs from Rv0572c by 1aa, L31F in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 666625 7564109 JTY_0587 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643649.1 666284 R 561275 CDS YP_002643650.1 224988963 7564110 complement(667093..668484) 1 NC_012207.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 668484 7564110 JTY_0588 Mycobacterium bovis BCG str. Tokyo 172 nicotinate phosphoribosyltransferase YP_002643650.1 667093 R 561275 CDS YP_002643651.1 224988964 7564111 complement(668494..669636) 1 NC_012207.1 Differs from Rv0574c by 1aa, K4N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 669636 7564111 JTY_0589 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643651.1 668494 R 561275 CDS YP_002643652.1 224988965 7564112 complement(669852..670988) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-C) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; hypothetical protein 670988 7564112 JTY_0590 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643652.1 669852 R 561275 CDS YP_002643653.1 224988966 7564113 671091..672395 1 NC_012207.1 Differs from Rv0576 by 1aa, H233R in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; possibly ArsR-family; transcriptional regulatory protein 672395 7564113 JTY_0591 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643653.1 671091 D 561275 CDS YP_002643654.1 224988967 7564114 672409..673194 1 NC_012207.1 hypothetical protein 673194 TB27.3 7564114 TB27.3 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643654.1 672409 D 561275 CDS YP_002643655.1 224988968 7561833 complement(673239..677159) 1 NC_012207.1 Differs from Rv0578c and from Mb0593c by 3aa, there are deleted in Mycobacterium bovis BCG Pasteur.; PE-PGRS family protein 677159 PE_PGRS7 7561833 PE_PGRS7 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002643655.1 673239 R 561275 CDS YP_002643656.1 224988969 7562392 677481..678239 1 NC_012207.1 hypothetical protein 678239 7562392 JTY_0594 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643656.1 677481 D 561275 CDS YP_002643657.1 224988970 7564115 complement(678368..678859) 1 NC_012207.1 hypothetical protein 678859 7564115 JTY_0595 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643657.1 678368 R 561275 CDS YP_002643658.1 224988971 7564116 678953..679168 1 NC_012207.1 hypothetical protein 679168 7564116 JTY_0596 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643658.1 678953 D 561275 CDS YP_002643659.1 224988972 7564117 679165..679572 1 NC_012207.1 hypothetical protein 679572 7564117 JTY_0597 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643659.1 679165 D 561275 CDS YP_002643660.1 224988973 7564118 complement(679632..680318) 1 NC_012207.1 lipoprotein 680318 lpqN 7564118 lpqN Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002643660.1 679632 R 561275 CDS YP_002643661.1 224988974 7560506 680472..683105 1 NC_012207.1 Differs from Rv0584 by 1aa G90D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 683105 7560506 JTY_0599 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643661.1 680472 D 561275 CDS YP_002643662.1 224988975 7564119 complement(683128..685515) 1 NC_012207.1 Differs from Rv0585c by 1aa V438I and from Mb0600c by 2aa M150I and V438I in BCG Pasteur and BCG Tokyo; integral membrane protein 685515 7564119 JTY_0600 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002643662.1 683128 R 561275 CDS YP_002643663.1 224988976 7564120 685653..686375 1 NC_012207.1 GntR-family; transcriptional regulatory protein 686375 7564120 JTY_0601 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643663.1 685653 D 561275 CDS YP_002643664.1 224988977 7564121 686372..687169 1 NC_012207.1 hypothetical protein 687169 yrbE2A 7564121 yrbE2A Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643664.1 686372 D 561275 CDS YP_002643665.1 224988978 7561452 687171..688058 1 NC_012207.1 hypothetical protein 688058 yrbE2B 7561452 yrbE2B Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643665.1 687171 D 561275 CDS YP_002643666.1 224988979 7561453 688064..689278 1 NC_012207.1 Differs from Rv0589 by 1aa S51F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; MCE-family protein 689278 mce2A 7561453 mce2A Mycobacterium bovis BCG str. Tokyo 172 MCE-family protein YP_002643666.1 688064 D 561275 CDS YP_002643667.1 224988980 7564437 689275..690306 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, mce2B and Rv0590A are 2 genes, most likely to be linked. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, an in-frame insertion of a single base (*-G) leads to a single product; MCE-family protein 690306 mce2B 7564437 mce2B Mycobacterium bovis BCG str. Tokyo 172 MCE-family protein YP_002643667.1 689275 D 561275 CDS YP_002643668.1 224988981 7564438 690303..691748 1 NC_012207.1 Differs from Rv0591 by 2aa M49T and N398T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; MCE-family protein 691748 mce2C 7564438 mce2C Mycobacterium bovis BCG str. Tokyo 172 MCE-family protein YP_002643668.1 690303 D 561275 CDS YP_002643669.1 224988982 7564439 691745..693295 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, mce2D exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a frameshift occurs in a strech of C (7 for H37Rv, 8 for Mycobactrium bovis and 9 for Mycobacterium bovis BCG). This leads to mceDa genes with different COOH parts and a remnant mc2Db pseudogene; MCE-family protein 693295 mce2Da 7564439 mce2Da Mycobacterium bovis BCG str. Tokyo 172 MCE-family protein YP_002643669.1 691745 D 561275 CDS YP_002643670.1 224988983 7564440 693270..694478 1 NC_012207.1 In Mycobacterium bovis, a single base transition (C-T) introducing a stop codon, leads to the formation of a truncated product compared to its homolog in Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (188 aa versus 402 aa); MCE-family lipoprotein 694478 lprL 7564440 lprL Mycobacterium bovis BCG str. Tokyo 172 MCE-family lipoprotein YP_002643670.1 693270 D 561275 CDS YP_002643671.1 224988984 7560530 694483..696033 1 NC_012207.1 MCE-family protein 696033 mce2F 7560530 mce2F Mycobacterium bovis BCG str. Tokyo 172 MCE-family protein YP_002643671.1 694483 D 561275 CDS YP_002643672.1 224988985 7564441 complement(696085..696477) 1 NC_012207.1 hypothetical protein 696477 7564441 JTY_0610 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643672.1 696085 R 561275 CDS YP_002643673.1 224988986 7564122 complement(696474..696731) 1 NC_012207.1 hypothetical protein 696731 7564122 JTY_0611 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643673.1 696474 R 561275 CDS YP_002643674.1 224988987 7564123 complement(696914..698149) 1 NC_012207.1 hypothetical protein 698149 7564123 JTY_0612 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643674.1 696914 R 561275 CDS YP_002643675.1 224988988 7564124 complement(698400..698813) 1 NC_012207.1 hypothetical protein 698813 7564124 JTY_0613 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643675.1 698400 R 561275 CDS YP_002643676.1 224988989 7564125 complement(698810..699046) 1 NC_012207.1 hypothetical protein 699046 7564125 JTY_0614 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643676.1 698810 R 561275 CDS YP_002643677.1 224988990 7564126 complement(699150..699656) 1 NC_012207.1 two component sensor kinase 699656 7564126 JTY_0615 Mycobacterium bovis BCG str. Tokyo 172 two component sensor kinase YP_002643677.1 699150 R 561275 CDS YP_002643678.1 224988991 7564127 complement(699770..700240) 1 NC_012207.1 first part; two component sensor kinase 700240 7564127 JTY_0616 Mycobacterium bovis BCG str. Tokyo 172 two component sensor kinase YP_002643678.1 699770 R 561275 CDS YP_002643679.1 224988992 7564128 complement(700284..701045) 1 NC_012207.1 Differs from Rv0602c by 1aa I28V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; two component DNA binding transcriptional regulatory protein 701045 tcrA 7564128 tcrA Mycobacterium bovis BCG str. Tokyo 172 two component DNA binding transcriptional regulatory protein YP_002643679.1 700284 R 561275 CDS YP_002643680.1 224988993 7561838 701102..701413 1 NC_012207.1 Differs from Mb0619 by 2aa P77A and E96K in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; hypothetical protein 701413 7561838 JTY_0618 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643680.1 701102 D 561275 CDS YP_002643681.1 224988994 7564129 701485..702435 1 NC_012207.1 Differs from Rv0604 by 1aa P180S in BCG Pasteur and BCG Tokyo; lipoprotein 702435 lpqO 7564129 lpqO Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002643681.1 701485 D 561275 CDS YP_002643682.1 224988995 7560507 702652..703260 1 NC_012207.1 resolvase 703260 7560507 JTY_0620 Mycobacterium bovis BCG str. Tokyo 172 resolvase YP_002643682.1 702652 D 561275 CDS YP_002643683.1 224988996 7564130 703262..704005 1 NC_012207.1 transposase 704005 7564130 JTY_0621 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002643683.1 703262 D 561275 CDS YP_002643684.1 224988997 7564131 704059..704445 1 NC_012207.1 hypothetical protein 704445 7564131 JTY_0622 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643684.1 704059 D 561275 CDS YP_002643685.1 224988998 7564132 704490..704735 1 NC_012207.1 hypothetical protein 704735 7564132 JTY_0623 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643685.1 704490 D 561275 CDS YP_002643686.1 224988999 7564133 704732..705133 1 NC_012207.1 hypothetical protein 705133 7564133 JTY_0624 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643686.1 704732 D 561275 CDS YP_002643687.1 224989000 7564134 705076..705303 1 NC_012207.1 hypothetical protein 705303 7564134 JTY_0625 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643687.1 705076 D 561275 CDS YP_002643688.1 224989001 7564135 complement(705998..707155) 1 NC_012207.1 Differs from Rv0610c by 1aa S103N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 707155 7564135 JTY_0626 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643688.1 705998 R 561275 CDS YP_002643689.1 224989002 7564136 complement(707207..707590) 1 NC_012207.1 hypothetical protein 707590 7564136 JTY_0627 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643689.1 707207 R 561275 CDS YP_002643690.1 224989003 7564137 707570..708175 1 NC_012207.1 hypothetical protein 708175 7564137 JTY_0628 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643690.1 707570 D 561275 CDS YP_002643691.1 224989004 7564138 complement(708194..710761) 1 NC_012207.1 hypothetical protein 710761 7564138 JTY_0629 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643691.1 708194 R 561275 CDS YP_002643692.1 224989005 7564139 710602..711594 1 NC_012207.1 hypothetical protein 711594 7564139 JTY_0630 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643692.1 710602 D 561275 CDS YP_002643693.1 224989006 7564140 711591..711833 1 NC_012207.1 integral membrane protein 711833 7564140 JTY_0631 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002643693.1 711591 D 561275 CDS YP_002643694.1 224989007 7564141 complement(711830..712096) 1 NC_012207.1 hypothetical protein 712096 7564141 JTY_0632 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643694.1 711830 R 561275 CDS YP_002643695.1 224989008 7564142 712028..712255 1 NC_012207.1 antitoxin 712255 7564142 JTY_0633 Mycobacterium bovis BCG str. Tokyo 172 antitoxin YP_002643695.1 712028 D 561275 CDS YP_002643696.1 224989009 7564143 712252..712653 1 NC_012207.1 hypothetical protein 712653 7564143 JTY_0634 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643696.1 712252 D 561275 CDS YP_002643697.1 224989010 7564144 712782..713966 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, galT is split into 2 parts, galT' and 'galT. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, an in-frame insertion of a single base (*-A) leads to a single product. Differs from Mb0635 by 1aa R183G and from Rv0619 by 1aa A397T in BCG Pasteur and BCG Tokyo; galactose-1-phosphate uridylyltransferase 713966 galT 7564144 galT Mycobacterium bovis BCG str. Tokyo 172 galactose-1-phosphate uridylyltransferase YP_002643697.1 712782 D 561275 CDS YP_002643698.1 224989011 7561900 713963..715054 1 NC_012207.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 715054 galK 7561900 galK Mycobacterium bovis BCG str. Tokyo 172 galactokinase YP_002643698.1 713963 D 561275 CDS YP_002643699.1 224989012 7561899 715449..716606 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (A-G) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (385 aa versus 354 aa); hypothetical protein 716606 7561899 JTY_0637 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643699.1 715449 D 561275 CDS YP_002643700.1 224989013 7564145 716617..717564 1 NC_012207.1 hypothetical protein 717564 7564145 JTY_0638 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643700.1 716617 D 561275 CDS YP_002643701.1 224989014 7564146 717657..717911 1 NC_012207.1 hypothetical protein 717911 7564146 JTY_0639 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643701.1 717657 D 561275 CDS YP_002643702.1 224989015 7564147 717911..718306 1 NC_012207.1 hypothetical protein 718306 7564147 JTY_0640 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643702.1 717911 D 561275 CDS YP_002643703.1 224989016 7564148 complement(718400..719140) 1 NC_012207.1 transmembrane protein 719140 7564148 JTY_0641 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643703.1 718400 R 561275 CDS YP_002643704.1 224989017 7564149 719272..719532 1 NC_012207.1 hypothetical protein 719532 7564149 JTY_0642 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643704.1 719272 D 561275 CDS YP_002643705.1 224989018 7564150 719529..719936 1 NC_012207.1 hypothetical protein 719936 7564150 JTY_0643 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643705.1 719529 D 561275 CDS YP_002643706.1 224989019 7564151 complement(720008..721159) 1 NC_012207.1 hypothetical protein 721159 7564151 JTY_0644 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643706.1 720008 R 561275 CDS YP_002643707.1 224989020 7564152 complement(721252..722979) 1 NC_012207.1 Differs from Rv0629c by 1aa A536T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; exonuclease V alpha chain 722979 recD 7564152 recD Mycobacterium bovis BCG str. Tokyo 172 exonuclease V alpha chain YP_002643707.1 721252 R 561275 CDS YP_002643708.1 224989021 7561555 complement(723566..726259) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, recB exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (G-*) splits recB into 2 parts, recBa and recBb. Differs from Mb0647c by 1aa H514R and from Rv0630c by 3aa L74V, H514R and F811V in BCG Pasteur and BCG Tokyo; exonuclease V subunit beta 726259 recBa 7561555 recBa Mycobacterium bovis BCG str. Tokyo 172 exonuclease V subunit beta YP_002643708.1 723566 R 561275 CDS YP_002643709.1 224989022 7561554 complement(726259..729552) 1 NC_012207.1 Differs from Rv0631c by 1aa E329G and from Mb0648c by 1aa P858L in BCG Pasteur and BCG Tokyo; exonuclease V gamma chain 729552 recC 7561554 recC Mycobacterium bovis BCG str. Tokyo 172 exonuclease V gamma chain YP_002643709.1 726259 R 561275 CDS YP_002643710.1 224989023 7561556 complement(729829..730524) 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 730524 echA3 7561556 echA3 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002643710.1 729829 R 561275 CDS YP_002643711.1 224989024 7561534 complement(730573..731403) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 9 bp deletion (CGGGTGCGC-*) leads to shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (Rv0633c) (276 aa versus 279 aa); hypothetical protein 731403 7561534 JTY_0650 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643711.1 730573 R 561275 CDS YP_002643712.1 224989025 7564153 complement(731557..732270) 1 NC_012207.1 glyoxalase II 732270 7564153 JTY_0651 Mycobacterium bovis BCG str. Tokyo 172 glyoxalase II YP_002643712.1 731557 R 561275 CDS YP_002643713.1 224989026 7564154 732350..732601 1 NC_012207.1 hypothetical protein 732601 7564154 JTY_0652 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643713.1 732350 D 561275 CDS YP_002643714.1 224989027 7564464 732949..733116 1 NC_012207.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 733116 rpmG 7564464 rpmG Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L33 YP_002643714.1 732949 D 561275 CDS YP_002643715.1 224989028 7560721 733167..733643 1 NC_012207.1 functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadA 733643 7560721 JTY_0654 Mycobacterium bovis BCG str. Tokyo 172 (3R)-hydroxyacyl-ACP dehydratase subunit HadA YP_002643715.1 733167 D 561275 CDS YP_002643716.1 224989029 7564156 733630..734058 1 NC_012207.1 functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadB 734058 7564156 JTY_0655 Mycobacterium bovis BCG str. Tokyo 172 (3R)-hydroxyacyl-ACP dehydratase subunit HadB YP_002643716.1 733630 D 561275 CDS YP_002643717.1 224989030 7564157 734062..734562 1 NC_012207.1 functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadC 734562 7564157 JTY_0656 Mycobacterium bovis BCG str. Tokyo 172 (3R)-hydroxyacyl-ACP dehydratase subunit HadC YP_002643717.1 734062 D 561275 CDS YP_002643718.1 224989031 7561635 734974..735459 1 NC_012207.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 735459 secE 7561635 secE Mycobacterium bovis BCG str. Tokyo 172 preprotein translocase subunit SecE YP_002643718.1 734974 D 561275 CDS YP_002643719.1 224989032 7560773 735491..736207 1 NC_012207.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 736207 nusG 7560773 nusG Mycobacterium bovis BCG str. Tokyo 172 transcription antitermination protein NusG YP_002643719.1 735491 D 561275 CDS YP_002643720.1 224989033 7562490 736259..736687 1 NC_012207.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 736687 rplK 7562490 rplK Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L11 YP_002643720.1 736259 D 561275 CDS YP_002643721.1 224989034 7561611 736754..737461 1 NC_012207.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 737461 rplA 7561611 rplA Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L1 YP_002643721.1 736754 D 561275 CDS YP_002643722.1 224989035 7561603 complement(737535..738440) 1 NC_012207.1 Differs from Rv0642c by 1aa L95F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methoxy mycolic acid synthase 4 738440 mmaA4 7561603 mmaA4 Mycobacterium bovis BCG str. Tokyo 172 methoxy mycolic acid synthase 4 YP_002643722.1 737535 R 561275 CDS YP_002643723.1 224989036 7564479 complement(738505..739386) 1 NC_012207.1 Differ from Rv0643c by 1aa, D98G in BCG Pasteur.; methoxy mycolic acid synthase 3 739386 mmaA3 7564479 mmaA3 Mycobacterium bovis BCG str. Tokyo 172 methoxy mycolic acid synthase 3 YP_002643723.1 738505 R 561275 CDS YP_002643724.1 224989037 7564478 complement(739534..740397) 1 NC_012207.1 Differs from Rv0644c by 1aa L114R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methoxy mycolic acid synthase 2 740397 mmaA2 7564478 mmaA2 Mycobacterium bovis BCG str. Tokyo 172 methoxy mycolic acid synthase 2 YP_002643724.1 739534 R 561275 CDS YP_002643725.1 224989038 7564477 complement(740564..741424) 1 NC_012207.1 methoxy mycolic acid synthase 1 741424 mmaA1 7564477 mmaA1 Mycobacterium bovis BCG str. Tokyo 172 methoxy mycolic acid synthase 1 YP_002643725.1 740564 R 561275 CDS YP_002643726.1 224989039 7564476 complement(741471..742376) 1 NC_012207.1 lipase/esterase 742376 lipG 7564476 lipG Mycobacterium bovis BCG str. Tokyo 172 lipase/esterase YP_002643726.1 741471 R 561275 CDS YP_002643727.1 224989040 7562835 complement(742388..743854) 1 NC_012207.1 Differs from Rv0647c by 1aa T293A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 743854 7562835 JTY_0666 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643727.1 742388 R 561275 CDS YP_002643728.1 224989041 7564159 743940..748136 1 NC_012207.1 Differs from Rv0648 by 1aa L200S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; alpha-mannosidase 748136 7564159 JTY_0667 Mycobacterium bovis BCG str. Tokyo 172 alpha-mannosidase YP_002643728.1 743940 D 561275 CDS YP_002643729.1 224989042 7564160 748133..748807 1 NC_012207.1 malonyl CoA-acyl carrier protein transacylase 748807 fabD2 7564160 fabD2 Mycobacterium bovis BCG str. Tokyo 172 malonyl CoA-acyl carrier protein transacylase YP_002643729.1 748133 D 561275 CDS YP_002643730.1 224989043 7562895 748807..749715 1 NC_012207.1 sugar kinase 749715 7562895 JTY_0669 Mycobacterium bovis BCG str. Tokyo 172 sugar kinase YP_002643730.1 748807 D 561275 CDS YP_002643731.1 224989044 7564161 750046..750582 1 NC_012207.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 750582 rplJ 7564161 rplJ Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L10 YP_002643731.1 750046 D 561275 CDS YP_002643732.1 224989045 7561610 750619..751011 1 NC_012207.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 751011 rplL 7561610 rplL Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L7/L12 YP_002643732.1 750619 D 561275 CDS YP_002643733.1 224989046 7561612 complement(751004..751699) 1 NC_012207.1 probably TetR-family; transcriptional regulatory protein 751699 7561612 JTY_0672 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643733.1 751004 R 561275 CDS YP_002643734.1 224989047 7564162 751770..753275 1 NC_012207.1 dioxygenase 753275 7564162 JTY_0673 Mycobacterium bovis BCG str. Tokyo 172 dioxygenase YP_002643734.1 751770 D 561275 CDS YP_002643735.1 224989048 7564163 753287..754366 1 NC_012207.1 ribonucleotide-transport ATP-binding protein ABC transporter 754366 mkl 7564163 mkl Mycobacterium bovis BCG str. Tokyo 172 ribonucleotide-transport ATP-binding protein ABC transporter YP_002643735.1 753287 D 561275 CDS YP_002643736.1 224989049 7564475 complement(754754..755137) 1 NC_012207.1 hypothetical protein 755137 7564475 JTY_0675 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643736.1 754754 R 561275 CDS YP_002643737.1 224989050 7564164 complement(755232..755387) 1 NC_012207.1 hypothetical protein 755387 7564164 JTY_0676 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643737.1 755232 R 561275 CDS YP_002643738.1 224989051 7564165 complement(755463..756179) 1 NC_012207.1 Differs from Rv0658c by 1aa P75L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; integral membrane protein 756179 7564165 JTY_0677 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002643738.1 755463 R 561275 CDS YP_002643739.1 224989052 7564166 complement(756455..756763) 1 NC_012207.1 hypothetical protein 756763 7564166 JTY_0678 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643739.1 756455 R 561275 CDS YP_002643740.1 224989053 7564167 complement(756750..756995) 1 NC_012207.1 hypothetical protein 756995 7564167 JTY_0679 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643740.1 756750 R 561275 CDS YP_002643741.1 224989054 7561040 complement(757105..757542) 1 NC_012207.1 hypothetical protein 757542 7561040 JTY_0680 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643741.1 757105 R 561275 CDS YP_002643742.1 224989055 7561041 complement(757539..757907) 1 NC_012207.1 hypothetical protein 757907 7561041 JTY_0681 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643742.1 757539 R 561275 CDS YP_002643743.1 224989056 7561042 757907..760270 1 NC_012207.1 Differs from Rv0663 by 1aa G349D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; arylsulfatase 760270 atsD 7561042 atsD Mycobacterium bovis BCG str. Tokyo 172 arylsulfatase YP_002643743.1 757907 D 561275 CDS YP_002643744.1 224989057 7562059 760302..760574 1 NC_012207.1 hypothetical protein 760574 7562059 JTY_0683 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643744.1 760302 D 561275 CDS YP_002643745.1 224989058 7561043 760571..760909 1 NC_012207.1 hypothetical protein 760909 7561043 JTY_0684 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643745.1 760571 D 561275 CDS YP_002643746.1 224989059 7561044 760906..761079 1 NC_012207.1 hypothetical protein 761079 7561044 JTY_0685 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643746.1 760906 D 561275 CDS YP_002643747.1 224989060 7561045 761577..765095 1 NC_012207.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 765095 rpoB 7561045 rpoB Mycobacterium bovis BCG str. Tokyo 172 DNA-directed RNA polymerase subunit beta YP_002643747.1 761577 D 561275 CDS YP_002643748.1 224989061 7560725 765140..769090 1 NC_012207.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 769090 rpoC 7560725 rpoC Mycobacterium bovis BCG str. Tokyo 172 DNA-directed RNA polymerase subunit beta' YP_002643748.1 765140 D 561275 CDS YP_002643749.1 224989062 7560726 complement(769454..771367) 1 NC_012207.1 Differs from Rv0669c by 1aa P146S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrolase 771367 7560726 JTY_0688 Mycobacterium bovis BCG str. Tokyo 172 hydrolase YP_002643749.1 769454 R 561275 CDS YP_002643750.1 224989063 7561046 771562..772320 1 NC_012207.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 772320 end 7561046 end Mycobacterium bovis BCG str. Tokyo 172 endonuclease IV YP_002643750.1 771562 D 561275 CDS YP_002643751.1 224989064 7562863 772352..773194 1 NC_012207.1 lipoprotein 773194 lpqP 7562863 lpqP Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002643751.1 772352 D 561275 CDS YP_002643752.1 224989065 7560508 773254..774882 1 NC_012207.1 acyl-CoA dehydrogenase 774882 fadE8 7560508 fadE8 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002643752.1 773254 D 561275 CDS YP_002643753.1 224989066 7563391 774893..775831 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 775831 echA4 7563391 echA4 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002643753.1 774893 D 561275 CDS YP_002643754.1 224989067 7561535 775834..776556 1 NC_012207.1 hypothetical protein 776556 7561535 JTY_0693 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643754.1 775834 D 561275 CDS YP_002643755.1 224989068 7561047 776553..777344 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 777344 echA5 7561047 echA5 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002643755.1 776553 D 561275 CDS YP_002643756.1 224989069 7561536 complement(777356..780250) 1 NC_012207.1 Differs from Rv0676c by 2aa I794T and V948I in Mycobacterium bovis BCG Pasteur, by 3aa I794T, I906V, V948I in Mycobacterium bovis BCG Tokyo.; transmembrane transport protein 780250 mmpL5 7561536 mmpL5 Mycobacterium bovis BCG str. Tokyo 172 transmembrane transport protein YP_002643756.1 777356 R 561275 CDS YP_002643757.1 224989070 7564490 complement(780247..780675) 1 NC_012207.1 membrane protein mmpS5 780675 mmpS5 7564490 mmpS5 Mycobacterium bovis BCG str. Tokyo 172 membrane protein mmpS5 YP_002643757.1 780247 R 561275 CDS YP_002643758.1 224989071 7563515 780760..781257 1 NC_012207.1 hypothetical protein 781257 7563515 JTY_0697 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643758.1 780760 D 561275 CDS YP_002643759.1 224989072 7561048 complement(781313..781810) 1 NC_012207.1 hypothetical threonine rich protein 781810 7561048 JTY_0698 Mycobacterium bovis BCG str. Tokyo 172 hypothetical threonine rich protein YP_002643759.1 781313 R 561275 CDS YP_002643760.1 224989073 7561049 complement(781812..782186) 1 NC_012207.1 transmembrane protein 782186 7561049 JTY_0699 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643760.1 781812 R 561275 CDS YP_002643761.1 224989074 7561050 782491..783081 1 NC_012207.1 possibly TetR-family; transcriptional regulatory protein 783081 7561050 JTY_0700 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643761.1 782491 D 561275 CDS YP_002643762.1 224989075 7561051 783330..783704 1 NC_012207.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 783704 rpsL 7561051 rpsL Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S12 YP_002643762.1 783330 D 561275 CDS YP_002643763.1 224989076 7560739 783704..784174 1 NC_012207.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 784174 rpsG 7560739 rpsG Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S7 YP_002643763.1 783704 D 561275 CDS YP_002643764.1 224989077 7560734 784255..786360 1 NC_012207.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 786360 fusA1 7560734 fusA1 Mycobacterium bovis BCG str. Tokyo 172 elongation factor G YP_002643764.1 784255 D 561275 CDS YP_002643765.1 224989078 7561888 786591..787781 1 NC_012207.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 787781 tuf 7561888 tuf Mycobacterium bovis BCG str. Tokyo 172 elongation factor Tu YP_002643765.1 786591 D 561275 CDS YP_002643766.1 224989079 7561644 787919..788716 1 NC_012207.1 Differs from Rv0686 by 1aa S82I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 788716 7561644 JTY_0705 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643766.1 787919 D 561275 CDS YP_002643767.1 224989080 7561052 788869..789696 1 NC_012207.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 789696 fabG 7561052 fabG Mycobacterium bovis BCG str. Tokyo 172 3-ketoacyl-ACP reductase YP_002643767.1 788869 D 561275 CDS YP_002643768.1 224989081 7562896 789710..790930 1 NC_012207.1 ferredoxin reductase 790930 7562896 JTY_0707 Mycobacterium bovis BCG str. Tokyo 172 ferredoxin reductase YP_002643768.1 789710 D 561275 CDS YP_002643769.1 224989082 7561053 complement(790927..791181) 1 NC_012207.1 hypothetical protein 791181 7561053 JTY_0708 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643769.1 790927 R 561275 CDS YP_002643770.1 224989083 7561054 complement(791794..792843) 1 NC_012207.1 hypothetical protein 792843 7561054 JTY_0709 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643770.1 791794 R 561275 CDS YP_002643771.1 224989084 7561055 complement(792840..793436) 1 NC_012207.1 transcriptional regulatory protein 793436 7561055 JTY_0710 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643771.1 792840 R 561275 CDS YP_002643772.1 224989085 7561056 793601..793930 1 NC_012207.1 hypothetical protein 793930 7561056 JTY_0711 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643772.1 793601 D 561275 CDS YP_002643773.1 224989086 7561057 793927..795102 1 NC_012207.1 coenzyme pqq synthesis protein E 795102 pqqE 7561057 pqqE Mycobacterium bovis BCG str. Tokyo 172 coenzyme pqq synthesis protein E YP_002643773.1 793927 D 561275 CDS YP_002643774.1 224989087 7560817 795105..796295 1 NC_012207.1 cytochrome; L-lactate dehydrogenase 796295 lldD1 7560817 lldD1 Mycobacterium bovis BCG str. Tokyo 172 L-lactate dehydrogenase YP_002643774.1 795105 D 561275 CDS YP_002643775.1 224989088 7562850 796485..797240 1 NC_012207.1 hypothetical protein 797240 7562850 JTY_0714 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643775.1 796485 D 561275 CDS YP_002643776.1 224989089 7561058 797289..798701 1 NC_012207.1 membrane sugar transferase 798701 7561058 JTY_0715 Mycobacterium bovis BCG str. Tokyo 172 membrane sugar transferase YP_002643776.1 797289 D 561275 CDS YP_002643777.1 224989090 7561059 798703..800142 1 NC_012207.1 dehydrogenase 800142 7561059 JTY_0716 Mycobacterium bovis BCG str. Tokyo 172 dehydrogenase YP_002643777.1 798703 D 561275 CDS YP_002643778.1 224989091 7561060 800603..800932 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718; hypothetical protein 800932 7561060 JTY_0717 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643778.1 800603 D 561275 CDS YP_002643779.1 224989092 7561061 800980..801213 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718; hypothetical protein 801213 7561061 JTY_0718 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643779.1 800980 D 561275 CDS YP_002643780.1 224989093 7561062 801398..801619 1 NC_012207.1 hypothetical protein 801619 7561062 JTY_0719 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643780.1 801398 D 561275 CDS YP_002643781.1 224989094 7561063 802256..802561 1 NC_012207.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 802561 rpsJ 7561063 rpsJ Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S10 YP_002643781.1 802256 D 561275 CDS YP_002643782.1 224989095 7560737 802578..803231 1 NC_012207.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 803231 rplC 7560737 rplC Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L3 YP_002643782.1 802578 D 561275 CDS YP_002643783.1 224989096 7561605 803231..803902 1 NC_012207.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 803902 rplD 7561605 rplD Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L4 YP_002643783.1 803231 D 561275 CDS YP_002643784.1 224989097 7561606 803902..804204 1 NC_012207.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 804204 rplW 7561606 rplW Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L23 YP_002643784.1 803902 D 561275 CDS YP_002643785.1 224989098 7561623 804351..805193 1 NC_012207.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 805193 rplB 7561623 rplB Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L2 YP_002643785.1 804351 D 561275 CDS YP_002643786.1 224989099 7561604 805234..805515 1 NC_012207.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 805515 rpsS 7561604 rpsS Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S19 YP_002643786.1 805234 D 561275 CDS YP_002643787.1 224989100 7560748 805512..806105 1 NC_012207.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 806105 rplV 7560748 rplV Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L22 YP_002643787.1 805512 D 561275 CDS YP_002643788.1 224989101 7561622 806105..806929 1 NC_012207.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 806929 rpsC 7561622 rpsC Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S3 YP_002643788.1 806105 D 561275 CDS YP_002643789.1 224989102 7560730 806933..807349 1 NC_012207.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 807349 rplP 7560730 rplP Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L16 YP_002643789.1 806933 D 561275 CDS YP_002643790.1 224989103 7561616 807349..807582 1 NC_012207.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 807582 rpmC 7561616 rpmC Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L29 YP_002643790.1 807349 D 561275 CDS YP_002643791.1 224989104 7560716 807579..807989 1 NC_012207.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 807989 rpsQ 7560716 rpsQ Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S17 YP_002643791.1 807579 D 561275 CDS YP_002643792.1 224989105 7560745 808158..810521 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, atsA exists as a single gene. In Mycobacterium bovis, a single base transversion (G-T), introducing a stop codon, splits atsA into 2 parts, atsAa and atsAb; arylsulfatase 810521 atsA 7560745 atsA Mycobacterium bovis BCG str. Tokyo 172 arylsulfatase YP_002643792.1 808158 D 561275 CDS YP_002643793.1 224989106 7562055 810569..811468 1 NC_012207.1 hypothetical protein 811468 7562055 JTY_0732 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643793.1 810569 D 561275 CDS YP_002643794.1 224989107 7561064 811769..812710 1 NC_012207.1 transmembrane protein 812710 7561064 JTY_0733 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643794.1 811769 D 561275 CDS YP_002643795.1 224989108 7561065 813196..813564 1 NC_012207.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 813564 rplN 7561065 rplN Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L14 YP_002643795.1 813196 D 561275 CDS YP_002643796.1 224989109 7561614 813565..813882 1 NC_012207.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 813882 rplX 7561614 rplX Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L24 YP_002643796.1 813565 D 561275 CDS YP_002643797.1 224989110 7561624 813882..814445 1 NC_012207.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 814445 rplE 7561624 rplE Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L5 YP_002643797.1 813882 D 561275 CDS YP_002643798.1 224989111 7561607 814450..814635 1 NC_012207.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 814635 rpsN 7561607 rpsN Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S14 YP_002643798.1 814450 D 561275 CDS YP_002643799.1 224989112 7560741 814799..815197 1 NC_012207.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 815197 rpsH 7560741 rpsH Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S8 YP_002643799.1 814799 D 561275 CDS YP_002643800.1 224989113 7560735 815221..815760 1 NC_012207.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 815760 rplF 7560735 rplF Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L6 YP_002643800.1 815221 D 561275 CDS YP_002643801.1 224989114 7561608 815763..816131 1 NC_012207.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 816131 rplR 7561608 rplR Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L18 YP_002643801.1 815763 D 561275 CDS YP_002643802.1 224989115 7561618 816151..816813 1 NC_012207.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 816813 rpsE 7561618 rpsE Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S5 YP_002643802.1 816151 D 561275 CDS YP_002643803.1 224989116 7560732 816816..817013 1 NC_012207.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 817013 rpmD 7560732 rpmD Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L30 YP_002643803.1 816816 D 561275 CDS YP_002643804.1 224989117 7560717 817013..817453 1 NC_012207.1 late assembly protein; 50S ribosomal protein L15 817453 rplO 7560717 rplO Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L15 YP_002643804.1 817013 D 561275 CDS YP_002643805.1 224989118 7561615 817486..819357 1 NC_012207.1 endopeptidase IV; protease IV 819357 sppA 7561615 sppA Mycobacterium bovis BCG str. Tokyo 172 protease IV YP_002643805.1 817486 D 561275 CDS YP_002643806.1 224989119 7561806 complement(819362..820267) 1 NC_012207.1 hypothetical protein 820267 7561806 JTY_0745 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643806.1 819362 R 561275 CDS YP_002643807.1 224989120 7561066 complement(820360..821463) 1 NC_012207.1 hypothetical protein 821463 7561066 JTY_0746 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643807.1 820360 R 561275 CDS YP_002643808.1 224989121 7561067 complement(821666..822322) 1 NC_012207.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose-phosphate aldolase 822322 fucA 7561067 fucA Mycobacterium bovis BCG str. Tokyo 172 L-fuculose-phosphate aldolase YP_002643808.1 821666 R 561275 CDS YP_002643809.1 224989122 7561884 complement(822319..823299) 1 NC_012207.1 Differs from Rv0728c by 1aa H242R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; D-3-phosphoglycerate dehydrogenase 823299 serA2 7561884 serA2 Mycobacterium bovis BCG str. Tokyo 172 D-3-phosphoglycerate dehydrogenase YP_002643809.1 822319 R 561275 CDS YP_002643810.1 224989123 7560780 823330..824676 1 NC_012207.1 Differs from Rv0729 by 2aa P134L and S439 in Mycobacterium bovis BCG Pasteur and BCG Tokyo; D-xylulose kinase 824676 xylB 7560780 xylB Mycobacterium bovis BCG str. Tokyo 172 D-xylulose kinase YP_002643810.1 823330 D 561275 CDS YP_002643811.1 224989124 7561701 824689..825417 1 NC_012207.1 hypothetical protein 825417 7561701 JTY_0750 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643811.1 824689 D 561275 CDS YP_002643812.1 224989125 7561068 complement(825506..826462) 1 NC_012207.1 hypothetical protein 826462 7561068 JTY_0751 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643812.1 825506 R 561275 CDS YP_002643813.1 224989126 7561069 826623..827948 1 NC_012207.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 827948 secY 7561069 secY Mycobacterium bovis BCG str. Tokyo 172 preprotein translocase subunit SecY YP_002643813.1 826623 D 561275 CDS YP_002643814.1 224989127 7560777 827945..828490 1 NC_012207.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 828490 adk 7560777 adk Mycobacterium bovis BCG str. Tokyo 172 adenylate kinase YP_002643814.1 827945 D 561275 CDS YP_002643815.1 224989128 7563947 828493..829293 1 NC_012207.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 829293 mapA 7563947 mapA Mycobacterium bovis BCG str. Tokyo 172 methionine aminopeptidase YP_002643815.1 828493 D 561275 CDS YP_002643816.1 224989129 7564418 829366..829899 1 NC_012207.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein regulates polyketide synthases and or membrane proteins; RNA polymerase sigma factor SigL 829899 sigL 7564418 sigL Mycobacterium bovis BCG str. Tokyo 172 RNA polymerase sigma factor SigL YP_002643816.1 829366 D 561275 CDS YP_002643817.1 224989130 7561796 829963..830715 1 NC_012207.1 hypothetical protein 830715 7561796 JTY_0756 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643817.1 829963 D 561275 CDS YP_002643818.1 224989131 7561070 831030..831527 1 NC_012207.1 transcriptional regulatory protein 831527 7561070 JTY_0757 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643818.1 831030 D 561275 CDS YP_002643819.1 224989132 7561071 831885..832433 1 NC_012207.1 hypothetical protein 832433 7561071 JTY_0758 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643819.1 831885 D 561275 CDS YP_002643820.1 224989133 7561072 832638..833486 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 2 bp insertion (*-CG) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (282 aa versus 268 aa); hypothetical protein 833486 7561072 JTY_0759 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643820.1 832638 D 561275 CDS YP_002643821.1 224989134 7561073 833601..834128 1 NC_012207.1 hypothetical protein 834128 7561073 JTY_0760 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643821.1 833601 D 561275 CDS YP_002643822.1 224989135 7561074 834359..834673 1 NC_012207.1 transposase 834673 7561074 JTY_0761 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002643822.1 834359 D 561275 CDS YP_002643823.1 224989136 7561075 834815..835333 1 NC_012207.1 PE-PGRS family protein 835333 PE_PGRS8 7561075 PE_PGRS8 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002643823.1 834815 D 561275 CDS YP_002643824.1 224989137 7562393 complement(835711..836268) 1 NC_012207.1 hypothetical protein 836268 7562393 JTY_0763 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643824.1 835711 R 561275 CDS YP_002643825.1 224989138 7561076 complement(836265..836771) 1 NC_012207.1 transcriptional regulatory protein 836771 7561076 JTY_0764 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643825.1 836265 R 561275 CDS YP_002643826.1 224989139 7561077 836979..837506 1 NC_012207.1 hypothetical protein 837506 7561077 JTY_0765 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643826.1 836979 D 561275 CDS YP_002643827.1 224989140 7561078 837526..839919 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, two 48 bp deletions, and a 138 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (797 aa versus 783 aa). Differs from Mb0767 by 1aa S597N in BCG Pasteur and BCG Tokyo; PE-PGRS family protein 839919 PE_PGRS9 7561078 PE_PGRS9 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002643827.1 837526 D 561275 CDS YP_002643828.1 224989141 7562394 840318..842999 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, insertions of 168 bp and 105 bp, a 11 bp for 71 bp substitution, and a 9 bp deletion (CGGCAACGG-*), leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (909 aa and 893 aa versus 801 aa). In addition, in Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 48 bp deletion compared to Mycobacterium bovis and Mycobacterium tuberculosis strain H37Rv. occurs; PE-PGRS family protein 842999 PE_PGRS10 7562394 PE_PGRS10 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002643828.1 840318 D 561275 CDS YP_002643829.1 224989142 7561749 843090..843347 1 NC_012207.1 hypothetical protein 843347 7561749 JTY_0768 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643829.1 843090 D 561275 CDS YP_002643830.1 224989143 7561079 843371..843799 1 NC_012207.1 hypothetical protein 843799 7561079 JTY_0769 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643830.1 843371 D 561275 CDS YP_002643831.1 224989144 7561080 complement(843880..844017) 1 NC_012207.1 hypothetical protein 844017 7561080 JTY_0770 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643831.1 843880 R 561275 CDS YP_002643832.1 224989145 7561081 844176..844421 1 NC_012207.1 hypothetical protein 844421 7561081 JTY_0771 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643832.1 844176 D 561275 CDS YP_002643833.1 224989146 7561082 complement(844490..845374) 1 NC_012207.1 3-hydroxyisobutyrate dehydrogenase 845374 mmsB 7561082 mmsB Mycobacterium bovis BCG str. Tokyo 172 3-hydroxyisobutyrate dehydrogenase YP_002643833.1 844490 R 561275 CDS YP_002643834.1 224989147 7563519 complement(845385..846557) 1 NC_012207.1 Differs from Rv0752c by 2aa A69V and V186I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acyl-CoA dehydrogenase 846557 fadE9 7563519 fadE9 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002643834.1 845385 R 561275 CDS YP_002643835.1 224989148 7563392 complement(846564..848096) 1 NC_012207.1 Differs from Mb0775c by 1aa V442G in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methylmalonate-semialdehyde dehydrogenase 848096 mmsA 7563392 mmsA Mycobacterium bovis BCG str. Tokyo 172 methylmalonate-semialdehyde dehydrogenase YP_002643835.1 846564 R 561275 CDS YP_002643836.1 224989149 7563518 848302..850056 1 NC_012207.1 PE-PGRS family protein 850056 PE_PGRS11 7563518 PE_PGRS11 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002643836.1 848302 D 561275 CDS YP_002643837.1 224989150 7561750 complement(850246..852183) 1 NC_012207.1 Differs from Rv0755c by 1aa K545R in BCG Pasteur and BCG Tokyo; PPE family protein 852183 PPE12 7561750 PPE12 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002643837.1 850246 R 561275 CDS YP_002643838.1 224989151 7562147 complement(852485..852670) 1 NC_012207.1 transposase 852670 7562147 JTY_0777 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002643838.1 852485 R 561275 CDS YP_002643839.1 224989152 7561856 complement(852884..853609) 1 NC_012207.1 hypothetical protein 853609 7561856 JTY_0778 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643839.1 852884 R 561275 CDS YP_002643840.1 224989153 7561084 855109..855852 1 NC_012207.1 two component system response transcriptional positive regulator 855852 phoP 7561084 phoP Mycobacterium bovis BCG str. Tokyo 172 two component system response transcriptional positive regulator YP_002643840.1 855109 D 561275 CDS YP_002643841.1 224989154 7562411 855897..857354 1 NC_012207.1 Differs from Rv0755c by 2aa I71G, L172P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; two component system response sensor kinase membrane associated 857354 phoR 7562411 phoR Mycobacterium bovis BCG str. Tokyo 172 two component system response sensor kinase membrane associated YP_002643841.1 855897 D 561275 CDS YP_002643842.1 224989155 7562412 complement(857326..857658) 1 NC_012207.1 hypothetical protein 857658 7562412 JTY_0781 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643842.1 857326 R 561275 CDS YP_002643843.1 224989156 7561085 complement(857767..858186) 1 NC_012207.1 hypothetical protein 858186 7561085 JTY_0782 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643843.1 857767 R 561275 CDS YP_002643844.1 224989157 7561086 complement(858199..859326) 1 NC_012207.1 zinc-containing alcohol dehydrogenase 859326 adhB 7561086 adhB Mycobacterium bovis BCG str. Tokyo 172 zinc-containing alcohol dehydrogenase YP_002643844.1 858199 R 561275 CDS YP_002643845.1 224989158 7563942 complement(859425..859970) 1 NC_012207.1 hypothetical protein 859970 7563942 JTY_0784 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643845.1 859425 R 561275 CDS YP_002643846.1 224989159 7561087 complement(859973..860179) 1 NC_012207.1 ferredoxin 860179 7561087 JTY_0785 Mycobacterium bovis BCG str. Tokyo 172 ferredoxin YP_002643846.1 859973 R 561275 CDS YP_002643847.1 224989160 7561088 complement(860182..861537) 1 NC_012207.1 cytochrome P450 51 861537 cyp51 7561088 cyp51 Mycobacterium bovis BCG str. Tokyo 172 cytochrome P450 51 YP_002643847.1 860182 R 561275 CDS YP_002643848.1 224989161 7563171 complement(861537..862364) 1 NC_012207.1 short chain dehydrogenase 862364 7563171 JTY_0787 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002643848.1 861537 R 561275 CDS YP_002643849.1 224989162 7561089 complement(861946..863571) 1 NC_012207.1 cytochrome P450 123 863571 cyp123 7561089 cyp123 Mycobacterium bovis BCG str. Tokyo 172 cytochrome P450 123 YP_002643849.1 861946 R 561275 CDS YP_002643850.1 224989163 7563154 complement(863568..864209) 1 NC_012207.1 hypothetical protein 864209 7563154 JTY_0789 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643850.1 863568 R 561275 CDS YP_002643851.1 224989164 7561090 864411..865880 1 NC_012207.1 aldehyde dehydrogenase 865880 aldA 7561090 aldA Mycobacterium bovis BCG str. Tokyo 172 aldehyde dehydrogenase YP_002643851.1 864411 D 561275 CDS YP_002643852.1 224989165 7563958 865911..866657 1 NC_012207.1 Differs from Rv0769 by 1aa V55A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; short chain dehydrogenase 866657 7563958 JTY_0791 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002643852.1 865911 D 561275 CDS YP_002643853.1 224989166 7561091 866755..867642 1 NC_012207.1 Differs from Mb0793 by 1aa V126G in BCG Pasteur and BCG Tokyo; dehydrogenase/reductase 867642 7561091 JTY_0792 Mycobacterium bovis BCG str. Tokyo 172 dehydrogenase/reductase YP_002643853.1 866755 D 561275 CDS YP_002643854.1 224989167 7561092 867639..868073 1 NC_012207.1 4-carboxymuconolactone decarboxylase 868073 7561092 JTY_0793 Mycobacterium bovis BCG str. Tokyo 172 4-carboxymuconolactone decarboxylase YP_002643854.1 867639 D 561275 CDS YP_002643855.1 224989168 7561093 868085..869353 1 NC_012207.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 869353 purD 7561093 purD Mycobacterium bovis BCG str. Tokyo 172 phosphoribosylamine--glycine ligase YP_002643855.1 868085 D 561275 CDS YP_002643856.1 224989169 7560857 complement(869350..870888) 1 NC_012207.1 gamma-glutamyltranspeptidase; cephalosporin acylase 870888 ggtA 7560857 ggtA Mycobacterium bovis BCG str. Tokyo 172 cephalosporin acylase YP_002643856.1 869350 R 561275 CDS YP_002643857.1 224989170 7561913 complement(870939..871850) 1 NC_012207.1 Differs from Rv0774c by 1aa A219S and from Mb0797c by 1aa D142A in BCG Pasteur and BCG Tokyo; hypothetical protein 871850 7561913 JTY_0796 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643857.1 870939 R 561275 CDS YP_002643858.1 224989171 7561094 871906..872529 1 NC_012207.1 hypothetical protein 872529 7561094 JTY_0797 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643858.1 871906 D 561275 CDS YP_002643859.1 224989172 7561095 complement(872483..873262) 1 NC_012207.1 hypothetical protein 873262 7561095 JTY_0798 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643859.1 872483 R 561275 CDS YP_002643860.1 224989173 7561096 873507..874925 1 NC_012207.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 874925 purB 7561096 purB Mycobacterium bovis BCG str. Tokyo 172 adenylosuccinate lyase YP_002643860.1 873507 D 561275 CDS YP_002643861.1 224989174 7560855 874930..876174 1 NC_012207.1 cytochrome P450 126 876174 cyp126 7560855 cyp126 Mycobacterium bovis BCG str. Tokyo 172 cytochrome P450 126 YP_002643861.1 874930 D 561275 CDS YP_002643862.1 224989175 7563157 complement(876171..876791) 1 NC_012207.1 transmembrane protein 876791 7563157 JTY_0801 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643862.1 876171 R 561275 CDS YP_002643863.1 224989176 7561097 876842..877735 1 NC_012207.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 877735 purC 7561097 purC Mycobacterium bovis BCG str. Tokyo 172 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_002643863.1 876842 D 561275 CDS YP_002643864.1 224989177 7560856 877732..879891 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, ptrB is split into 2 genes, ptrBa and ptrBb, due to a frameshift. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 2 bp insertion (*-gc) leads to a single product; oligopeptidase B; protease II 879891 ptrB 7560856 ptrB Mycobacterium bovis BCG str. Tokyo 172 protease II YP_002643864.1 877732 D 561275 CDS YP_002643865.1 224989178 7560853 complement(880319..881941) 1 NC_012207.1 multidrug resistance integral membrane efflux protein 881941 emrB 7560853 emrB Mycobacterium bovis BCG str. Tokyo 172 multidrug resistance integral membrane efflux protein YP_002643865.1 880319 R 561275 CDS YP_002643866.1 224989179 7562862 882139..882825 1 NC_012207.1 hypothetical protein 882825 7562862 JTY_0805 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643866.1 882139 D 561275 CDS YP_002643867.1 224989180 7561098 882841..883416 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (T-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808; hypothetical protein 883416 7561098 JTY_0806 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643867.1 882841 D 561275 CDS YP_002643868.1 224989181 7561099 883434..884540 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo, a frameshift due to a single base deletion (T-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808; hypothetical protein 884540 7561099 JTY_0807 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643868.1 883434 D 561275 CDS YP_002643869.1 224989182 7561100 complement(884575..884964) 1 NC_012207.1 hypothetical protein 884964 7561100 JTY_0808 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643869.1 884575 R 561275 CDS YP_002643870.1 224989183 7561101 884959..885918 1 NC_012207.1 Differs from Rv0787 by 1aa H269Y in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 885918 7561101 JTY_0809 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643870.1 884959 D 561275 CDS YP_002643871.1 224989184 7561102 886024..886263 1 NC_012207.1 With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway; phosphoribosylformylglycinamidine synthase subunit PurS 886263 7561102 JTY_0810 Mycobacterium bovis BCG str. Tokyo 172 phosphoribosylformylglycinamidine synthase subunit PurS YP_002643871.1 886024 D 561275 CDS YP_002643872.1 224989185 7561103 886260..886934 1 NC_012207.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I 886934 purQ 7561103 purQ Mycobacterium bovis BCG str. Tokyo 172 phosphoribosylformylglycinamidine synthase I YP_002643872.1 886260 D 561275 CDS YP_002643873.1 224989186 7560865 complement(886951..887550) 1 NC_012207.1 hypothetical protein 887550 7560865 JTY_0812 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643873.1 886951 R 561275 CDS YP_002643874.1 224989187 7561104 complement(887572..888300) 1 NC_012207.1 hypothetical protein 888300 7561104 JTY_0813 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643874.1 887572 R 561275 CDS YP_002643875.1 224989188 7561105 complement(888297..889340) 1 NC_012207.1 hypothetical protein 889340 7561105 JTY_0814 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643875.1 888297 R 561275 CDS YP_002643876.1 224989189 7561106 complement(889337..890146) 1 NC_012207.1 probably GntR-family; transcriptional regulatory protein 890146 7561106 JTY_0815 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643876.1 889337 R 561275 CDS YP_002643877.1 224989190 7561107 890219..890524 1 NC_012207.1 hypothetical protein 890524 7561107 JTY_0816 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643877.1 890219 D 561275 CDS YP_002643878.1 224989191 7561108 complement(890637..891248) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (a-*) splits Rv0794c into 2 parts; oxidoreductase 891248 7561108 JTY_0817 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002643878.1 890637 R 561275 CDS YP_002643879.1 224989192 7561109 complement(891236..892135) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (a-*) splits Rv0794c into 2 parts; oxidoreductase 892135 7561109 JTY_0818 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002643879.1 891236 R 561275 CDS YP_002643880.1 224989193 7561111 complement(893611..894408) 1 NC_012207.1 hypothetical protein 894408 cfp29 7561111 cfp29 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643880.1 893611 R 561275 CDS YP_002643881.1 224989194 7562100 complement(894405..895412) 1 NC_012207.1 hypothetical protein 895412 7562100 JTY_0821 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643881.1 894405 R 561275 CDS YP_002643882.1 224989195 7561112 895457..896758 1 NC_012207.1 catalyzes the removal of amino acids from the N termini of peptides; aminopeptidase 2 896758 pepC 7561112 pepC Mycobacterium bovis BCG str. Tokyo 172 aminopeptidase 2 YP_002643882.1 895457 D 561275 CDS YP_002643883.1 224989196 7561743 896770..897117 1 NC_012207.1 hypothetical protein 897117 7561743 JTY_0823 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643883.1 896770 D 561275 CDS YP_002643884.1 224989197 7561113 complement(897111..897767) 1 NC_012207.1 hypothetical protein 897767 7561113 JTY_0824 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643884.1 897111 R 561275 CDS YP_002643885.1 224989198 7561114 897959..900223 1 NC_012207.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II 900223 purL 7561114 purL Mycobacterium bovis BCG str. Tokyo 172 phosphoribosylformylglycinamidine synthase II YP_002643885.1 897959 D 561275 CDS YP_002643886.1 224989199 7560862 900220..900849 1 NC_012207.1 hypothetical protein 900849 7560862 JTY_0826 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643886.1 900220 D 561275 CDS YP_002643887.1 224989200 7561115 900970..901926 1 NC_012207.1 hypothetical protein 901926 7561115 JTY_0827 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643887.1 900970 D 561275 CDS YP_002643888.1 224989201 7561116 complement(901871..903469) 1 NC_012207.1 UDP-glucose-4-epimerase 903469 cpsY 7561116 cpsY Mycobacterium bovis BCG str. Tokyo 172 UDP-glucose-4-epimerase YP_002643888.1 901871 R 561275 CDS YP_002643889.1 224989202 7563122 903774..904163 1 NC_012207.1 hypothetical protein 904163 7563122 JTY_0829 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643889.1 903774 D 561275 CDS YP_002643890.1 224989203 7561117 904250..905833 1 NC_012207.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 905833 purF 7561117 purF Mycobacterium bovis BCG str. Tokyo 172 amidophosphoribosyltransferase YP_002643890.1 904250 D 561275 CDS YP_002643891.1 224989204 7560859 905864..906958 1 NC_012207.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 906958 purM 7560859 purM Mycobacterium bovis BCG str. Tokyo 172 phosphoribosylaminoimidazole synthetase YP_002643891.1 905864 D 561275 CDS YP_002643892.1 224989205 7560863 complement(907044..907226) 1 NC_012207.1 hypothetical protein 907226 7560863 JTY_0832 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643892.1 907044 R 561275 CDS YP_002643893.1 224989206 7561118 complement(907373..908479) 1 NC_012207.1 hypothetical protein 908479 7561118 JTY_0833 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643893.1 907373 R 561275 CDS YP_002643894.1 224989207 7561119 908562..909431 1 NC_012207.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 909431 7561119 JTY_0834 Mycobacterium bovis BCG str. Tokyo 172 4-amino-4-deoxychorismate lyase YP_002643894.1 908562 D 561275 CDS YP_002643895.1 224989208 7561120 complement(909477..910157) 1 NC_012207.1 hypothetical protein 910157 7561120 JTY_0835 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643895.1 909477 R 561275 CDS YP_002643896.1 224989209 7561121 complement(910320..910622) 1 NC_012207.1 hypothetical protein 910622 sseC2 7561121 sseC2 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643896.1 910320 R 561275 CDS YP_002643897.1 224989210 7561810 complement(910624..911457) 1 NC_012207.1 thiosulfate sulfurtransferase 911457 cysA2 7561810 cysA2 Mycobacterium bovis BCG str. Tokyo 172 thiosulfate sulfurtransferase YP_002643897.1 910624 R 561275 CDS YP_002643898.1 224989211 7563173 complement(911750..912172) 1 NC_012207.1 thioredoxin 912172 thiX 7563173 thiX Mycobacterium bovis BCG str. Tokyo 172 thioredoxin YP_002643898.1 911750 R 561275 CDS YP_002643899.1 224989212 7561849 complement(912169..912981) 1 NC_012207.1 hypothetical protein 912981 7561849 JTY_0839 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643899.1 912169 R 561275 CDS YP_002643900.1 224989213 7561954 913111..913878 1 NC_012207.1 Differs from Rv0818 by 1aa P97L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional regulatory protein 913878 7561954 JTY_0840 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643900.1 913111 D 561275 CDS YP_002643901.1 224989214 7561955 913875..914822 1 NC_012207.1 hypothetical protein 914822 7561955 JTY_0841 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643901.1 913875 D 561275 CDS YP_002643902.1 224989215 7561956 914865..915377 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis phoT exists as a single gene. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a frameshift due to a single base deletion (G-*), splits phoT into two parts phoTa and phoTb. Differs from Rv0820 by 1aa L35F in BCG Pasteur and BCG Tokyo; phosphate-transport ATP-binding protein ABC transporter 915377 phoTa 7561956 phoTa Mycobacterium bovis BCG str. Tokyo 172 phosphate-transport ATP-binding protein ABC transporter YP_002643902.1 914865 D 561275 CDS YP_002643903.1 224989216 7562414 complement(915696..916337) 1 NC_012207.1 phosphate-transport system transcriptional regulatory protein 916337 phoY2 7562414 phoY2 Mycobacterium bovis BCG str. Tokyo 172 phosphate-transport system transcriptional regulatory protein YP_002643903.1 915696 R 561275 CDS YP_002643904.1 224989217 7562418 complement(916395..918449) 1 NC_012207.1 Differs from Rv0822c by 1aa P89H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 918449 7562418 JTY_0845 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643904.1 916395 R 561275 CDS YP_002643905.1 224989218 7561957 complement(918615..919784) 1 NC_012207.1 Differs from Rv0823c by 2aa C130G and L330F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional regulatory protein 919784 7561957 JTY_0846 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643905.1 918615 R 561275 CDS YP_002643906.1 224989219 7561958 complement(919872..920888) 1 NC_012207.1 acyl-ACP desaturase 920888 desA1 7561958 desA1 Mycobacterium bovis BCG str. Tokyo 172 acyl-ACP desaturase YP_002643906.1 919872 R 561275 CDS YP_002643907.1 224989220 7561483 complement(921050..921691) 1 NC_012207.1 hypothetical protein 921691 7561483 JTY_0848 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643907.1 921050 R 561275 CDS YP_002643908.1 224989221 7561959 921772..922827 1 NC_012207.1 Differs from Rv0826 by 1aa Q294R and Mb0849 by 1aaE97G in BCG Pasteur and BCG Tokyo; hypothetical protein 922827 7561959 JTY_0849 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643908.1 921772 D 561275 CDS YP_002643909.1 224989222 7561960 complement(922879..923271) 1 NC_012207.1 transcriptional regulatory protein 923271 7561960 JTY_0850 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643909.1 922879 R 561275 CDS YP_002643910.1 224989223 7561961 complement(923329..923751) 1 NC_012207.1 deaminase 923751 7561961 JTY_0851 Mycobacterium bovis BCG str. Tokyo 172 deaminase YP_002643910.1 923329 R 561275 CDS YP_002643911.1 224989224 7561962 923713..924003 1 NC_012207.1 Differs from Rv0829 by 1aa G80A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transposase 924003 7561962 JTY_0852 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002643911.1 923713 D 561275 CDS YP_002643912.1 224989225 7561963 924108..925013 1 NC_012207.1 hypothetical protein 925013 7561963 JTY_0853 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643912.1 924108 D 561275 CDS YP_002643913.1 224989226 7561964 complement(925032..925847) 1 NC_012207.1 hypothetical protein 925847 7561964 JTY_0854 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643913.1 925032 R 561275 CDS YP_002643914.1 224989227 7562407 927089..929821 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur and BCG Tokyo, PE-PGRS13 exist as a single gene. In Mycobacterium tuberculosis and Mycobacterium bovis, it is splitted in 2 genes PE-PGRS12 and PE-PGRS13; PE-PGRS family protein 929821 PE_PGRS13 7562407 PE_PGRS13 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002643914.1 927089 D 561275 CDS YP_002643915.1 224989228 7561751 complement(930048..932696) 1 NC_012207.1 In Mycobacterium bovis, deletions of 143 bp and 9 bp (cgccgttgc-*), leads to a shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (831 aa versus 882 aa); PE-PGRS family protein 932696 PE_PGRS14 7561751 PE_PGRS14 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002643915.1 930048 R 561275 CDS YP_002643916.1 224989229 7561752 933164..933808 1 NC_012207.1 Differs from Rv0835 by 1aa G162D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 933808 lpqQ 7561752 lpqQ Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002643916.1 933164 D 561275 CDS YP_002643917.1 224989230 7560509 complement(934421..935143) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (a-g) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (240 aa versus 217 aa); hypothetical protein 935143 7560509 JTY_0858 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643917.1 934421 R 561275 CDS YP_002643918.1 224989231 7561966 complement(935214..936242) 1 NC_012207.1 hypothetical protein 936242 7561966 JTY_0859 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643918.1 935214 R 561275 CDS YP_002643919.1 224989232 7561967 936931..937713 1 NC_012207.1 In Mycobacterium bovis, a 6bp insertion (*-CGGCCC) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (258 aa versus 256 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 12bp insertion (compared to its homolog in Mycobacterium tuberculosis strain H37Rv) and a 6bp insertion (compared to its homolog in Mycobacterium bovis) leads to an even longer product (260 aa); lipoprotein 937713 lpqR 7561967 lpqR Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002643919.1 936931 D 561275 CDS YP_002643920.1 224989233 7560510 937800..938612 1 NC_012207.1 hypothetical protein 938612 7560510 JTY_0861 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643920.1 937800 D 561275 CDS YP_002643921.1 224989234 7561968 complement(938680..939540) 1 NC_012207.1 proline iminopeptidase 939540 pip 7561968 pip Mycobacterium bovis BCG str. Tokyo 172 proline iminopeptidase YP_002643921.1 938680 R 561275 CDS YP_002643922.1 224989235 7562424 939816..940058 1 NC_012207.1 Differs from Rv0841 by 1aa F29V in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; transmembrane protein 940058 7562424 JTY_0863 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643922.1 939816 D 561275 CDS YP_002643923.1 224989236 7561969 940335..941627 1 NC_012207.1 integral membrane protein 941627 7561969 JTY_0864 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002643923.1 940335 D 561275 CDS YP_002643924.1 224989237 7561970 941611..942615 1 NC_012207.1 Differs from Rv0843 by 1aa G191D and from Mb0866 by 1aa A309D in BCG Pasteur and BCG Tokyo; dehydrogenase 942615 7561970 JTY_0865 Mycobacterium bovis BCG str. Tokyo 172 dehydrogenase YP_002643924.1 941611 D 561275 CDS YP_002643925.1 224989238 7561971 complement(942679..943329) 1 NC_012207.1 Differs from Mb0867c by 1aa A73P in BCG Pasteur and BCG Tokyo; nitrate/nitrite response transcriptional regulatory protein 943329 narL 7561971 narL Mycobacterium bovis BCG str. Tokyo 172 nitrate/nitrite response transcriptional regulatory protein YP_002643925.1 942679 R 561275 CDS YP_002643926.1 224989239 7562452 943413..944690 1 NC_012207.1 Differs from Rv0845 by 1aa E219A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; two component sensor kinase 944690 7562452 JTY_0867 Mycobacterium bovis BCG str. Tokyo 172 two component sensor kinase YP_002643926.1 943413 D 561275 CDS YP_002643927.1 224989240 7561972 complement(944903..946417) 1 NC_012207.1 Differs from Mb0869c by 1aa Y411H in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidase 946417 7561972 JTY_0868 Mycobacterium bovis BCG str. Tokyo 172 oxidase YP_002643927.1 944903 R 561275 CDS YP_002643928.1 224989241 7561973 946566..946958 1 NC_012207.1 Differs from Rv0847 by 1aa V128A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 946958 lpqS 7561973 lpqS Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002643928.1 946566 D 561275 CDS YP_002643929.1 224989242 7560511 947161..948279 1 NC_012207.1 Differs from Rv0848 by 1aa S93G, and from Mb0871 by 1aa V137G in BCG Pasteur and BCG Tokyo; cysteine synthase A 948279 cysK2 7560511 cysK2 Mycobacterium bovis BCG str. Tokyo 172 cysteine synthase A YP_002643929.1 947161 D 561275 CDS YP_002643930.1 224989243 7563179 948279..949538 1 NC_012207.1 integral membrane transport protein 949538 7563179 JTY_0871 Mycobacterium bovis BCG str. Tokyo 172 integral membrane transport protein YP_002643930.1 948279 D 561275 CDS YP_002643931.1 224989244 7561974 949535..949867 1 NC_012207.1 transposase 949867 7561974 JTY_0872 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002643931.1 949535 D 561275 CDS YP_002643932.1 224989245 7561975 complement(949864..950691) 1 NC_012207.1 Differs from Rv0851c by 1aa G59S and from Mb0874c by 1aa V84F in BCG Pasteur and BCG Tokyo; short chain dehydrogenase 950691 7561975 JTY_0873 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002643932.1 949864 R 561275 CDS YP_002643933.1 224989246 7561976 950782..951618 1 NC_012207.1 fatty-acid-CoA ligase 951618 fadD16 7561976 fadD16 Mycobacterium bovis BCG str. Tokyo 172 fatty-acid-CoA ligase YP_002643933.1 950782 D 561275 CDS YP_002643934.1 224989247 7562922 complement(951659..953341) 1 NC_012207.1 pyruvate or indole-3-pyruvate decarboxylase 953341 pdc 7562922 pdc Mycobacterium bovis BCG str. Tokyo 172 pyruvate or indole-3-pyruvate decarboxylase YP_002643934.1 951659 R 561275 CDS YP_002643935.1 224989248 7562526 953406..953849 1 NC_012207.1 hypothetical protein 953849 7562526 JTY_0876 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643935.1 953406 D 561275 CDS YP_002643936.1 224989249 7561977 953855..954934 1 NC_012207.1 fatty-acid-CoA racemase 954934 far 7561977 far Mycobacterium bovis BCG str. Tokyo 172 fatty-acid-CoA racemase YP_002643936.1 953855 D 561275 CDS YP_002643937.1 224989250 7563394 955047..955451 1 NC_012207.1 hypothetical protein 955451 7563394 JTY_0878 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643937.1 955047 D 561275 CDS YP_002643938.1 224989251 7561978 955479..955952 1 NC_012207.1 hypothetical protein 955952 7561978 JTY_0879 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643938.1 955479 D 561275 CDS YP_002643939.1 224989252 7561979 complement(955949..957142) 1 NC_012207.1 aminotransferase 957142 7561979 JTY_0880 Mycobacterium bovis BCG str. Tokyo 172 aminotransferase YP_002643939.1 955949 R 561275 CDS YP_002643940.1 224989253 7561980 957299..958510 1 NC_012207.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 958510 fadA 7561980 fadA Mycobacterium bovis BCG str. Tokyo 172 acetyl-CoA acetyltransferase YP_002643940.1 957299 D 561275 CDS YP_002643941.1 224989254 7562904 958515..960677 1 NC_012207.1 Differs from Rv0860 by 1aa T701A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; fatty oxidation protein 960677 fadB 7562904 fadB Mycobacterium bovis BCG str. Tokyo 172 fatty oxidation protein YP_002643941.1 958515 D 561275 CDS YP_002643942.1 224989255 7562910 complement(960745..962373) 1 NC_012207.1 Differs from Rv0861c by 1aa A258V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; DNA helicase 962373 7562910 JTY_0883 Mycobacterium bovis BCG str. Tokyo 172 DNA helicase YP_002643942.1 960745 R 561275 CDS YP_002643943.1 224989256 7561981 complement(962511..964781) 1 NC_012207.1 Differs from Rv0862c by 2aa F224L and S749L, and from Mb0885c by 1aa F224L in BCG Pasteur and BCG Tokyo; hypothetical protein 964781 7561981 JTY_0884 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643943.1 962511 R 561275 CDS YP_002643944.1 224989257 7561982 964768..965049 1 NC_012207.1 hypothetical protein 965049 7561982 JTY_0885 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643944.1 964768 D 561275 CDS YP_002643945.1 224989258 7561983 965133..965561 1 NC_012207.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 965561 moaC 7561983 moaC Mycobacterium bovis BCG str. Tokyo 172 molybdenum cofactor biosynthesis protein MoaC YP_002643945.1 965133 D 561275 CDS YP_002643946.1 224989259 7563530 965558..966040 1 NC_012207.1 molybdopterin biosynthesis protein 966040 mog 7563530 mog Mycobacterium bovis BCG str. Tokyo 172 molybdopterin biosynthesis protein YP_002643946.1 965558 D 561275 CDS YP_002643947.1 224989260 7563546 966037..966462 1 NC_012207.1 molybdenum cofactor biosynthesis protein E2 966462 moaE2 7563546 moaE2 Mycobacterium bovis BCG str. Tokyo 172 molybdenum cofactor biosynthesis protein E2 YP_002643947.1 966037 D 561275 CDS YP_002643948.1 224989261 7563533 complement(966480..967703) 1 NC_012207.1 In Mycobacterium bovis, a 240 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (327 aa versus 407 aa). Differs from Rv0867c by 1aa E235D in BCG Pasteur and BCG Tokyo.; resuscitation-promoting factor 967703 rpfA 7563533 rpfA Mycobacterium bovis BCG str. Tokyo 172 resuscitation-promoting factor YP_002643948.1 966480 R 561275 CDS YP_002643949.1 224989262 7561596 complement(968151..968429) 1 NC_012207.1 molybdenum cofactor biosynthesis protein D 2 968429 moaD2 7561596 moaD2 Mycobacterium bovis BCG str. Tokyo 172 molybdenum cofactor biosynthesis protein D 2 YP_002643949.1 968151 R 561275 CDS YP_002643950.1 224989263 7563532 complement(968433..969515) 1 NC_012207.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 969515 moaA 7563532 moaA Mycobacterium bovis BCG str. Tokyo 172 molybdenum cofactor biosynthesis protein A YP_002643950.1 968433 R 561275 CDS YP_002643951.1 224989264 7563522 complement(969512..969901) 1 NC_012207.1 Differs from Mb0894c by 1aa G29S; hypothetical protein 969901 7563522 JTY_0892 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643951.1 969512 R 561275 CDS YP_002643952.1 224989265 7561984 970066..970473 1 NC_012207.1 cold shock-like protein B 970473 cspB 7561984 cspB Mycobacterium bovis BCG str. Tokyo 172 cold shock-like protein B YP_002643952.1 970066 D 561275 CDS YP_002643953.1 224989266 7563125 complement(970592..972421) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 9 bp in-frame insertion (compared to Mycobacterium tuberculosis strain H37Rv), leads to a lightly longer product (609 aa versus 606 aa). In Mycobacterium bovis, an additional 3 bp in-frame deletion (compared to Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur and BCG Tokyo) leads to a product of 608 aa; PE-PGRS family protein 972421 PE_PGRS15 7563125 PE_PGRS15 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002643953.1 970592 R 561275 CDS YP_002643954.1 224989267 7561753 972682..974634 1 NC_012207.1 acyl-CoA dehydrogenase 974634 fadE10 7561753 fadE10 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002643954.1 972682 D 561275 CDS YP_002643955.1 224989268 7563359 complement(974723..975883) 1 NC_012207.1 hypothetical protein 975883 7563359 JTY_0896 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643955.1 974723 R 561275 CDS YP_002643956.1 224989269 7561985 complement(975983..976471) 1 NC_012207.1 hypothetical protein 976471 7561985 JTY_0897 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643956.1 975983 R 561275 CDS YP_002643957.1 224989270 7561986 complement(976468..978114) 1 NC_012207.1 Differs from Mb0900c by 1aa D26G in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 978114 7561986 JTY_0898 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643957.1 976468 R 561275 CDS YP_002643958.1 224989271 7561987 978252..979040 1 NC_012207.1 hypothetical protein 979040 7561987 JTY_0899 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643958.1 978252 D 561275 CDS YP_002643959.1 224989272 7561988 complement(979049..980377) 1 NC_012207.1 In Mycobacterium bovis, Mycobaterium bovis BCG Pasteur, and BCG Tokyo, a single base deletion (A-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (438 aa versus 443 aa). Differs from Rv0878c and Mb0902c by 1aa K436Q in BCG Pasteur and BCG Tokyo; PPE family protein 980377 PPE13 7561988 PPE13 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002643959.1 979049 R 561275 CDS YP_002643960.1 224989273 7562148 complement(980655..980930) 1 NC_012207.1 transmembrane protein 980930 7562148 JTY_0901 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643960.1 980655 R 561275 CDS YP_002643961.1 224989274 7561989 981108..981539 1 NC_012207.1 possibly MarR-family; transcriptional regulatory protein 981539 7561989 JTY_0902 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643961.1 981108 D 561275 CDS YP_002643962.1 224989275 7561990 981536..982402 1 NC_012207.1 rRNA methyltransferase 982402 7561990 JTY_0903 Mycobacterium bovis BCG str. Tokyo 172 rRNA methyltransferase YP_002643962.1 981536 D 561275 CDS YP_002643963.1 224989276 7561991 982399..982683 1 NC_012207.1 transmembrane protein 982683 7561991 JTY_0904 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643963.1 982399 D 561275 CDS YP_002643964.1 224989277 7561992 complement(982680..983441) 1 NC_012207.1 hypothetical protein 983441 7561992 JTY_0905 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643964.1 982680 R 561275 CDS YP_002643965.1 224989278 7561993 complement(983598..984728) 1 NC_012207.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase 984728 serC 7561993 serC Mycobacterium bovis BCG str. Tokyo 172 phosphoserine aminotransferase YP_002643965.1 983598 R 561275 CDS YP_002643966.1 224989279 7560783 984936..985958 1 NC_012207.1 hypothetical protein 985958 7560783 JTY_0907 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643966.1 984936 D 561275 CDS YP_002643967.1 224989280 7561994 985977..987704 1 NC_012207.1 NADPH:adrenodoxin oxidoreductase 987704 fprB 7561994 fprB Mycobacterium bovis BCG str. Tokyo 172 NADPH:adrenodoxin oxidoreductase YP_002643967.1 985977 D 561275 CDS YP_002643968.1 224989281 7563428 complement(987687..988145) 1 NC_012207.1 hypothetical protein 988145 7563428 JTY_0909 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643968.1 987687 R 561275 CDS YP_002643969.1 224989282 7561995 989407..990879 1 NC_012207.1 hypothetical protein 990879 7561995 JTY_0910 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643969.1 989407 D 561275 CDS YP_002643970.1 224989283 7561996 complement(990914..992035) 1 NC_012207.1 forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; citrate synthase 2 992035 citA 7561996 citA Mycobacterium bovis BCG str. Tokyo 172 citrate synthase 2 YP_002643970.1 990914 R 561275 CDS YP_002643971.1 224989284 7562105 complement(992122..994770) 1 NC_012207.1 Differs from Rv0890c by 1aa A866P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably LuxR-family; transcriptional regulatory protein 994770 7562105 JTY_0912 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643971.1 992122 R 561275 CDS YP_002643972.1 224989285 7561997 complement(994772..995629) 1 NC_012207.1 Differs from Rv0891c by 1aa G37V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional regulatory protein 995629 7561997 JTY_0913 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643972.1 994772 R 561275 CDS YP_002643973.1 224989286 7561998 996027..997514 1 NC_012207.1 monooxygenase 997514 7561998 JTY_0914 Mycobacterium bovis BCG str. Tokyo 172 monooxygenase YP_002643973.1 996027 D 561275 CDS YP_002643974.1 224989287 7561999 complement(997492..998469) 1 NC_012207.1 hypothetical protein 998469 7561999 JTY_0915 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643974.1 997492 R 561275 CDS YP_002643975.1 224989288 7562000 998698..999879 1 NC_012207.1 possibly LuxR-family; transcriptional regulatory protein 999879 7562000 JTY_0916 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002643975.1 998698 D 561275 CDS YP_002643976.1 224989289 7562001 999956..1001473 1 NC_012207.1 hypothetical protein 1001473 7562001 JTY_0917 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643976.1 999956 D 561275 CDS YP_002643977.1 224989290 7562002 1001663..1002958 1 NC_012207.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 1002958 gltA 7562002 gltA Mycobacterium bovis BCG str. Tokyo 172 type II citrate synthase YP_002643977.1 1001663 D 561275 CDS YP_002643978.1 224989291 7561945 complement(1002999..1004606) 1 NC_012207.1 oxidoreductase 1004606 7561945 JTY_0919 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002643978.1 1002999 R 561275 CDS YP_002643979.1 224989292 7562003 complement(1004632..1004895) 1 NC_012207.1 hypothetical protein 1004895 7562003 JTY_0920 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643979.1 1004632 R 561275 CDS YP_002643980.1 224989293 7562004 1005003..1005983 1 NC_012207.1 outer membrane protein A 1005983 ompA 7562004 ompA Mycobacterium bovis BCG str. Tokyo 172 outer membrane protein A YP_002643980.1 1005003 D 561275 CDS YP_002643981.1 224989294 7562493 1005996..1006148 1 NC_012207.1 hypothetical protein 1006148 7562493 JTY_0922 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643981.1 1005996 D 561275 CDS YP_002643982.1 224989295 7562005 1006148..1006675 1 NC_012207.1 exported or membrane protein 1006675 7562005 JTY_0923 Mycobacterium bovis BCG str. Tokyo 172 exported or membrane protein YP_002643982.1 1006148 D 561275 CDS YP_002643983.1 224989296 7562006 complement(1006692..1008032) 1 NC_012207.1 two component sensor histidine kinase 1008032 prrB 7562006 prrB Mycobacterium bovis BCG str. Tokyo 172 two component sensor histidine kinase YP_002643983.1 1006692 R 561275 CDS YP_002643984.1 224989297 7560836 complement(1008043..1008753) 1 NC_012207.1 two component response transcriptional regulatory protein 1008753 prrA 7560836 prrA Mycobacterium bovis BCG str. Tokyo 172 two component response transcriptional regulatory protein YP_002643984.1 1008043 R 561275 CDS YP_002643985.1 224989298 7560835 complement(1008884..1010371) 1 NC_012207.1 acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 1010371 accD3 7560835 accD3 Mycobacterium bovis BCG str. Tokyo 172 acetyl-coenzyme A carboxylase carboxyl transferase subunit beta YP_002643985.1 1008884 R 561275 CDS YP_002643986.1 224989299 7563923 1010398..1011129 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1011129 echA6 7563923 echA6 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002643986.1 1010398 D 561275 CDS YP_002643987.1 224989300 7561537 1011135..1012253 1 NC_012207.1 hypothetical protein 1012253 7561537 JTY_0928 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643987.1 1011135 D 561275 CDS YP_002643988.1 224989301 7562007 1012346..1013926 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-G) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Rv0907 by 1aa, L322P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1013926 7562007 JTY_0929 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643988.1 1012346 D 561275 CDS YP_002643989.1 224989302 7562008 1013923..1016316 1 NC_012207.1 metal cation transporter ATPase P-type 1016316 ctpE 7562008 ctpE Mycobacterium bovis BCG str. Tokyo 172 metal cation transporter ATPase P-type YP_002643989.1 1013923 D 561275 CDS YP_002643990.1 224989303 7563135 1016873..1017052 1 NC_012207.1 Differs from Rv0909 by 1aa, Q45H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1017052 7563135 JTY_0931 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643990.1 1016873 D 561275 CDS YP_002643991.1 224989304 7562009 1017058..1017492 1 NC_012207.1 hypothetical protein 1017492 7562009 JTY_0932 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643991.1 1017058 D 561275 CDS YP_002643992.1 224989305 7562010 1017590..1018363 1 NC_012207.1 hypothetical protein 1018363 7562010 JTY_0933 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643992.1 1017590 D 561275 CDS YP_002643993.1 224989306 7562011 1018428..1018877 1 NC_012207.1 transmembrane protein 1018877 7562011 JTY_0934 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002643993.1 1018428 D 561275 CDS YP_002643994.1 224989307 7562012 complement(1019409..1020917) 1 NC_012207.1 Differs from Mb0937c by 1aa P233L in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; dioxygenase 1020917 7562012 JTY_0935 Mycobacterium bovis BCG str. Tokyo 172 dioxygenase YP_002643994.1 1019409 R 561275 CDS YP_002643995.1 224989308 7562013 complement(1020919..1022157) 1 NC_012207.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 1022157 7562013 JTY_0936 Mycobacterium bovis BCG str. Tokyo 172 acetyl-CoA acetyltransferase YP_002643995.1 1020919 R 561275 CDS YP_002643996.1 224989309 7562014 complement(1022250..1023521) 1 NC_012207.1 PPE family protein 1023521 PPE14 7562014 PPE14 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002643996.1 1022250 R 561275 CDS YP_002643997.1 224989310 7562149 complement(1023536..1023835) 1 NC_012207.1 PE family protein 1023835 PE7 7562149 PE7 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002643997.1 1023536 R 561275 CDS YP_002643998.1 224989311 7561738 1024279..1026060 1 NC_012207.1 glycine betaine transport integral membrane protein 1026060 betP 7561738 betP Mycobacterium bovis BCG str. Tokyo 172 glycine betaine transport integral membrane protein YP_002643998.1 1024279 D 561275 CDS YP_002643999.1 224989312 7562062 1026403..1026879 1 NC_012207.1 Differs from Rv0918 by 1aa, G46S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1026879 7562062 JTY_0940 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002643999.1 1026403 D 561275 CDS YP_002644000.1 224989313 7562015 1026876..1027376 1 NC_012207.1 hypothetical protein 1027376 7562015 JTY_0941 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644000.1 1026876 D 561275 CDS YP_002644001.1 224989314 7563992 complement(1027689..1029008) 1 NC_012207.1 Differs from Rv0920c by 1aa, E249D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transposase 1029008 7563992 JTY_0942 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002644001.1 1027689 R 561275 CDS YP_002644002.1 224989315 7562017 1029296..1029877 1 NC_012207.1 resolvase 1029877 7562017 JTY_0943 Mycobacterium bovis BCG str. Tokyo 172 resolvase YP_002644002.1 1029296 D 561275 CDS YP_002644003.1 224989316 7562018 1029877..1031529 1 NC_012207.1 transposase 1031529 7562018 JTY_0944 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002644003.1 1029877 D 561275 CDS YP_002644004.1 224989317 7562019 complement(1031705..1032769) 1 NC_012207.1 hypothetical protein 1032769 7562019 JTY_0945 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644004.1 1031705 R 561275 CDS YP_002644005.1 224989318 7562020 complement(1032770..1034056) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, Rv0924c and Rv0925c exist as 2 genes. In Mycobacterium bovis, a single base deletion (T-*) leads to a single product, Mb0948c. Differs from Rv0924c by 1aa, A216P in BCG Pasteur and BCG Tokyo; manganese transport protein MntH 1034056 mntH 7562020 mntH Mycobacterium bovis BCG str. Tokyo 172 manganese transport protein MntH YP_002644005.1 1032770 R 561275 CDS YP_002644006.1 224989319 7563521 complement(1034088..1034825) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, Rv0924c and Rv0925c exist as 2 genes. In Mycobacterium bovis, a single base deletion (t-*) leads to a single product, Mb0948c; Nramp; Mramp; divalent cation-transport integral membrane protein 1034825 7563521 JTY_0947 Mycobacterium bovis BCG str. Tokyo 172 divalent cation-transport integral membrane protein YP_002644006.1 1034088 R 561275 CDS YP_002644007.1 224989320 7562021 complement(1034902..1035978) 1 NC_012207.1 hypothetical protein 1035978 7562021 JTY_0948 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644007.1 1034902 R 561275 CDS YP_002644008.1 224989321 7562022 complement(1036032..1036823) 1 NC_012207.1 short chain dehydrogenase 1036823 7562022 JTY_0949 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002644008.1 1036032 R 561275 CDS YP_002644009.1 224989322 7562023 1037095..1038207 1 NC_012207.1 periplasmic phosphate-binding lipoprotein 1038207 pstS3 7562023 pstS3 Mycobacterium bovis BCG str. Tokyo 172 periplasmic phosphate-binding lipoprotein YP_002644009.1 1037095 D 561275 CDS YP_002644010.1 224989323 7560848 1038220..1039194 1 NC_012207.1 phosphate ABC transporter permease 1039194 pstC2 7560848 pstC2 Mycobacterium bovis BCG str. Tokyo 172 phosphate ABC transporter permease YP_002644010.1 1038220 D 561275 CDS YP_002644011.1 224989324 7560845 1039191..1040105 1 NC_012207.1 Differs from Rv0930 by 1aa, T5M in Mycobacterium CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; phosphate-transport integral membrane ABC transporter 1040105 pstA1 7560845 pstA1 Mycobacterium bovis BCG str. Tokyo 172 phosphate-transport integral membrane ABC transporter YP_002644011.1 1039191 D 561275 CDS YP_002644012.1 224989325 7560840 complement(1040112..1041221) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-T) splits pknD into 2 parts,pknDa and pknDb; hypothetical protein 1041221 pknDb 7560840 pknDb Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644012.1 1040112 R 561275 CDS YP_002644013.1 224989326 7562431 complement(1041232..1042107) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-T) splits pknD into 2 parts,pknDa and pknDb; transmembrane serine/threonine-protein kinase 1042107 pknDa 7562431 pknDa Mycobacterium bovis BCG str. Tokyo 172 transmembrane serine/threonine-protein kinase YP_002644013.1 1041232 R 561275 CDS YP_002644014.1 224989327 7562430 complement(1042129..1043241) 1 NC_012207.1 Differs from Rv0932c by 1aa, A115S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; periplasmic phosphate-binding lipoprotein 1043241 pstS2 7562430 pstS2 Mycobacterium bovis BCG str. Tokyo 172 periplasmic phosphate-binding lipoprotein YP_002644014.1 1042129 R 561275 CDS YP_002644015.1 224989328 7560847 1043457..1043672 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-T, position 1041448-1041449) splits pstB into 2 parts, pstBa and pstBb; phosphate-transport protein ABC transporter 1043672 pstBa 7560847 pstBa Mycobacterium bovis BCG str. Tokyo 172 phosphate-transport protein ABC transporter YP_002644015.1 1043457 D 561275 CDS YP_002644016.1 224989329 7560842 1043647..1044288 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-T, position 1041448-1041449) splits pstB into 2 parts, pstBa and pstBb; phosphate-transport protein ABC transporter 1044288 pstBb 7560842 pstBb Mycobacterium bovis BCG str. Tokyo 172 phosphate-transport protein ABC transporter YP_002644016.1 1043647 D 561275 CDS YP_002644017.1 224989330 7560843 1044309..1045433 1 NC_012207.1 Differs from Rv0934 by 1aa, A352V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; periplasmic phosphate-binding lipoprotein 1045433 pstS1 7560843 pstS1 Mycobacterium bovis BCG str. Tokyo 172 periplasmic phosphate-binding lipoprotein YP_002644017.1 1044309 D 561275 CDS YP_002644018.1 224989331 7560846 1045493..1046509 1 NC_012207.1 phosphate ABC transporter permease 1046509 pstC1 7560846 pstC1 Mycobacterium bovis BCG str. Tokyo 172 phosphate ABC transporter permease YP_002644018.1 1045493 D 561275 CDS YP_002644019.1 224989332 7560844 1046511..1047416 1 NC_012207.1 phosphate ABC transporter permease 1047416 pstA2 7560844 pstA2 Mycobacterium bovis BCG str. Tokyo 172 phosphate ABC transporter permease YP_002644019.1 1046511 D 561275 CDS YP_002644020.1 224989333 7560841 complement(1047393..1048214) 1 NC_012207.1 hypothetical protein 1048214 7560841 JTY_0961 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644020.1 1047393 R 561275 CDS YP_002644021.1 224989334 7562024 1048330..1050609 1 NC_012207.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA and has been shown to have polymerase activity; ATP-dependent DNA ligase 1050609 7562024 JTY_0962 Mycobacterium bovis BCG str. Tokyo 172 ATP-dependent DNA ligase YP_002644021.1 1048330 D 561275 CDS YP_002644022.1 224989335 7562025 1050606..1052540 1 NC_012207.1 cyclase/dehydrase; 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase 1052540 7562025 JTY_0963 Mycobacterium bovis BCG str. Tokyo 172 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase YP_002644022.1 1050606 D 561275 CDS YP_002644023.1 224989336 7562026 complement(1052787..1053653) 1 NC_012207.1 oxidoreductase 1053653 7562026 JTY_0964 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002644023.1 1052787 R 561275 CDS YP_002644024.1 224989337 7562027 complement(1053738..1054511) 1 NC_012207.1 hypothetical protein 1054511 7562027 JTY_0965 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644024.1 1053738 R 561275 CDS YP_002644025.1 224989338 7562028 1054554..1054832 1 NC_012207.1 hypothetical protein 1054832 7562028 JTY_0966 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644025.1 1054554 D 561275 CDS YP_002644026.1 224989339 7562029 complement(1054890..1055930) 1 NC_012207.1 monooxygenase 1055930 7562029 JTY_0967 Mycobacterium bovis BCG str. Tokyo 172 monooxygenase YP_002644026.1 1054890 R 561275 CDS YP_002644027.1 224989340 7562030 1055959..1056435 1 NC_012207.1 formamidopyrimidine-DNA glycosylase 1056435 7562030 JTY_0968 Mycobacterium bovis BCG str. Tokyo 172 formamidopyrimidine-DNA glycosylase YP_002644027.1 1055959 D 561275 CDS YP_002644028.1 224989341 7562031 1056441..1057202 1 NC_012207.1 Differs from Rv0945 by 1aa, G180R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; short chain dehydrogenase 1057202 7562031 JTY_0969 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002644028.1 1056441 D 561275 CDS YP_002644029.1 224989342 7562032 complement(1057218..1058879) 1 NC_012207.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1058879 pgi 7562032 pgi Mycobacterium bovis BCG str. Tokyo 172 glucose-6-phosphate isomerase YP_002644029.1 1057218 R 561275 CDS YP_002644030.1 224989343 7562398 complement(1059494..1059724) 1 NC_012207.1 mycolyl transferase 1059724 7562398 JTY_0971 Mycobacterium bovis BCG str. Tokyo 172 mycolyl transferase YP_002644030.1 1059494 R 561275 CDS YP_002644031.1 224989344 7562033 complement(1059840..1060157) 1 NC_012207.1 hypothetical protein 1060157 7562033 JTY_0972 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644031.1 1059840 R 561275 CDS YP_002644032.1 224989345 7562034 1060454..1062769 1 NC_012207.1 ATP dependent dna helicase 1062769 uvrD1 7562034 uvrD1 Mycobacterium bovis BCG str. Tokyo 172 ATP dependent dna helicase YP_002644032.1 1060454 D 561275 CDS YP_002644033.1 224989346 7561675 complement(1062850..1063848) 1 NC_012207.1 hypothetical protein 1063848 7561675 JTY_0974 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644033.1 1062850 R 561275 CDS YP_002644034.1 224989347 7562035 1064158..1065321 1 NC_012207.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1065321 sucC 7562035 sucC Mycobacterium bovis BCG str. Tokyo 172 succinyl-CoA synthetase subunit beta YP_002644034.1 1064158 D 561275 CDS YP_002644035.1 224989348 7561813 1065334..1066245 1 NC_012207.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 1066245 sucD 7561813 sucD Mycobacterium bovis BCG str. Tokyo 172 succinyl-CoA synthetase subunit alpha YP_002644035.1 1065334 D 561275 CDS YP_002644036.1 224989349 7561814 complement(1066242..1067099) 1 NC_012207.1 Differs from Rv0953c and Mb0978c by 1aa, A50T in Mycobacterium bovis BCG Pasteur and BCG Tokyo; oxidoreductase 1067099 7561814 JTY_0977 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002644036.1 1066242 R 561275 CDS YP_002644037.1 224989350 7563430 1067264..1068175 1 NC_012207.1 transmembrane protein 1068175 7563430 JTY_0978 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002644037.1 1067264 D 561275 CDS YP_002644038.1 224989351 7563431 1068215..1069582 1 NC_012207.1 integral membrane protein 1069582 7563431 JTY_0979 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002644038.1 1068215 D 561275 CDS YP_002644039.1 224989352 7563432 1069698..1070345 1 NC_012207.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 1070345 purN 7563432 purN Mycobacterium bovis BCG str. Tokyo 172 phosphoribosylglycinamide formyltransferase YP_002644039.1 1069698 D 561275 CDS YP_002644040.1 224989353 7560864 1070342..1071913 1 NC_012207.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1071913 purH 7560864 purH Mycobacterium bovis BCG str. Tokyo 172 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_002644040.1 1070342 D 561275 CDS YP_002644041.1 224989354 7560860 1072020..1073399 1 NC_012207.1 Differs from Rv0958 by 1aa, P274S in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; magnesium chelatase 1073399 7560860 JTY_0982 Mycobacterium bovis BCG str. Tokyo 172 magnesium chelatase YP_002644041.1 1072020 D 561275 CDS YP_002644042.1 224989355 7563433 1073392..1075410 1 NC_012207.1 hypothetical protein 1075410 7563433 JTY_0983 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644042.1 1073392 D 561275 CDS YP_002644043.1 224989356 7563434 1075464..1075685 1 NC_012207.1 antitoxin 1075685 7563434 JTY_0984 Mycobacterium bovis BCG str. Tokyo 172 antitoxin YP_002644043.1 1075464 D 561275 CDS YP_002644044.1 224989357 7563435 1075682..1076065 1 NC_012207.1 hypothetical protein 1076065 7563435 JTY_0985 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644044.1 1075682 D 561275 CDS YP_002644045.1 224989358 7563436 1076211..1076558 1 NC_012207.1 hypothetical protein 1076558 7563436 JTY_0986 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644045.1 1076211 D 561275 CDS YP_002644046.1 224989359 7563437 complement(1076577..1077251) 1 NC_012207.1 Differs from Rv0962c by 1aa, L186P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 1077251 lprP 7563437 lprP Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644046.1 1076577 R 561275 CDS YP_002644047.1 224989360 7560533 complement(1077434..1078234) 1 NC_012207.1 Differs from Rv0963c and Mb0988c by 1aa, S258G in BCG Pasteur and BCG Tokyo; hypothetical protein 1078234 7560533 JTY_0988 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644047.1 1077434 R 561275 CDS YP_002644048.1 224989361 7563438 complement(1078333..1078815) 1 NC_012207.1 Differs from Rv0964c by 1aa, T124P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1078815 7563438 JTY_0989 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644048.1 1078333 R 561275 CDS YP_002644049.1 224989362 7563439 complement(1078915..1079334) 1 NC_012207.1 Differs from Rv0965c by 1aa, H94R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1079334 7563439 JTY_0990 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644049.1 1078915 R 561275 CDS YP_002644050.1 224989363 7563440 complement(1079370..1079972) 1 NC_012207.1 Differs from Rv0966c by 2aa, A175V, G186W in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1079972 7563440 JTY_0991 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644050.1 1079370 R 561275 CDS YP_002644051.1 224989364 7563441 1080111..1080470 1 NC_012207.1 hypothetical protein 1080470 7563441 JTY_0992 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644051.1 1080111 D 561275 CDS YP_002644052.1 224989365 7563442 1080527..1080823 1 NC_012207.1 hypothetical protein 1080823 7563442 JTY_0993 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644052.1 1080527 D 561275 CDS YP_002644053.1 224989366 7563443 1080879..1083191 1 NC_012207.1 Differs from Rv0969 by 1aa, N484D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; metal cation transporter P-type ATPase 1083191 ctpV 7563443 ctpV Mycobacterium bovis BCG str. Tokyo 172 metal cation transporter P-type ATPase YP_002644053.1 1080879 D 561275 CDS YP_002644054.1 224989367 7563141 1083188..1083820 1 NC_012207.1 integral membrane protein 1083820 7563141 JTY_0995 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002644054.1 1083188 D 561275 CDS YP_002644055.1 224989368 7563444 complement(1083911..1084720) 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1084720 echA7 7563444 echA7 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002644055.1 1083911 R 561275 CDS YP_002644056.1 224989369 7561538 complement(1084720..1085886) 1 NC_012207.1 Differs from Rv0972c by 1aa, H236Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acyl-CoA dehydrogenase 1085886 fadE12 7561538 fadE12 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002644056.1 1084720 R 561275 CDS YP_002644057.1 224989370 7563360 complement(1085883..1087886) 1 NC_012207.1 Differs from Rv0973c by 1aa, F220I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acetyl-/propionyl-coenzyme A carboxylase alpha chain subunit alpha 1087886 accA2 7563360 accA2 Mycobacterium bovis BCG str. Tokyo 172 acetyl-/propionyl-coenzyme A carboxylase alpha chain subunit alpha YP_002644057.1 1085883 R 561275 CDS YP_002644058.1 224989371 7564330 complement(1087892..1089481) 1 NC_012207.1 Differs from Rv0974c by 1aa, K51N in Mycobacteium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo; acetyl-/propionyl-coa carboxylase subunit beta 1089481 accD2 7564330 accD2 Mycobacterium bovis BCG str. Tokyo 172 acetyl-/propionyl-coa carboxylase subunit beta YP_002644058.1 1087892 R 561275 CDS YP_002644059.1 224989372 7563922 complement(1089484..1090632) 1 NC_012207.1 In Mycobacterium bovis, a frameshift due to a single base deletion (T-*) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG pasteur, and BCG Tokyo; acyl-CoA dehydrogenase 1090632 fadE13 7563922 fadE13 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002644059.1 1089484 R 561275 CDS YP_002644060.1 224989373 7563361 complement(1090629..1092311) 1 NC_012207.1 hypothetical protein 1092311 7563361 JTY_1001 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644060.1 1090629 R 561275 CDS YP_002644061.1 224989374 7563445 1092510..1094003 1 NC_012207.1 PE-PGRS family protein 1094003 PE_PGRS16 7563445 PE_PGRS16 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644061.1 1092510 D 561275 CDS YP_002644062.1 224989375 7561754 1093960..1095282 1 NC_012207.1 PE-PGRS family protein 1095282 PE_PGRS16 7561754 PE_PGRS16 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644062.1 1093960 D 561275 CDS YP_002644063.1 224989376 7561755 complement(1095499..1096506) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterim bovis BCG Pasteur, and BCG Tokyo, a 115 bp to 127 bp substitution leads to as lightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (335 aa versus 331aa); PE-PGRS family protein 1096506 PE_PGRS17 7561755 PE_PGRS17 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644063.1 1095499 R 561275 CDS YP_002644064.1 224989377 7561756 complement(1096820..1097014) 1 NC_012207.1 hypothetical protein 1097014 7561756 JTY_1005 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644064.1 1096820 R 561275 CDS YP_002644065.1 224989378 7563446 1097036..1097209 1 NC_012207.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1097209 rpmF 7563446 rpmF Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L32 YP_002644065.1 1097036 D 561275 CDS YP_002644066.1 224989379 7560719 complement(1097228..1098601) 1 NC_012207.1 Differs from Rv0980c by 1aa, Q43H, and from Mb1006c by 1aa, A270T in Mycobacteium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo; PE-PGRS family protein 1098601 PE_PGRS18 7560719 PE_PGRS18 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644066.1 1097228 R 561275 CDS YP_002644067.1 224989380 7561757 1098966..1099658 1 NC_012207.1 Differs from Rv0981 by 1aa, S70G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo; persistence regulator MprA 1099658 mprA 7561757 mprA Mycobacterium bovis BCG str. Tokyo 172 persistence regulator MprA YP_002644067.1 1098966 D 561275 CDS YP_002644068.1 224989381 7563553 1099658..1101172 1 NC_012207.1 Differs from Rv0982 by 1aa, H339L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo; two component sensor kinase 1101172 mprB 7563553 mprB Mycobacterium bovis BCG str. Tokyo 172 two component sensor kinase YP_002644068.1 1099658 D 561275 CDS YP_002644069.1 224989382 7563554 1101216..1102610 1 NC_012207.1 Differs from Rv0983 by 1aa, P390L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo; serine protease 1102610 7563554 JTY_1010 Mycobacterium bovis BCG str. Tokyo 172 serine protease YP_002644069.1 1101216 D 561275 CDS YP_002644070.1 224989383 7563447 1102610..1103155 1 NC_012207.1 pterin-4-alpha-carbinolamine dehydratase 1103155 moaB2 7563447 moaB2 Mycobacterium bovis BCG str. Tokyo 172 pterin-4-alpha-carbinolamine dehydratase YP_002644070.1 1102610 D 561275 CDS YP_002644071.1 224989384 7563526 complement(1103175..1103630) 1 NC_012207.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 1103630 mscL 7563526 mscL Mycobacterium bovis BCG str. Tokyo 172 large-conductance mechanosensitive channel YP_002644071.1 1103175 R 561275 CDS YP_002644072.1 224989385 7563563 1103953..1104699 1 NC_012207.1 Differs from Rv0986 by 1aa, L228V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo; adhesion component transport ATP-binding protein ABC transporter 1104699 7563563 JTY_1013 Mycobacterium bovis BCG str. Tokyo 172 adhesion component transport ATP-binding protein ABC transporter YP_002644072.1 1103953 D 561275 CDS YP_002644073.1 224989386 7563448 1104692..1107259 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, Rv0987 exists as a single gene. In Mycobacterium bovis, a single base transition (G-A) introduces a stop codon that splits Rv0987 in two parts, Mb1013 and Mb1014. Differs from Rv0987 by 1aa, V717F in BCG Pasteur and BCG Tokyo; adhesion component transport transmembrane protein ABC transporter 1107259 7563448 JTY_1014 Mycobacterium bovis BCG str. Tokyo 172 adhesion component transport transmembrane protein ABC transporter YP_002644073.1 1104692 D 561275 CDS YP_002644074.1 224989387 7563449 1107266..1108426 1 NC_012207.1 Differs from Rv0988 by 2aa, I57V, D135Y in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; hypothetical protein 1108426 7563449 JTY_1015 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644074.1 1107266 D 561275 CDS YP_002644075.1 224989388 7563450 complement(1108555..1109532) 1 NC_012207.1 Differs from Rv0989c by 1aa, V321I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo; polyprenyl-diphosphate synthase 1109532 grcC2 7563450 grcC2 Mycobacterium bovis BCG str. Tokyo 172 polyprenyl-diphosphate synthase YP_002644075.1 1108555 R 561275 CDS YP_002644076.1 224989389 7563280 complement(1109593..1110249) 1 NC_012207.1 Differs from Rv0990c by 1aa, A54S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; hypothetical protein 1110249 7563280 JTY_1017 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644076.1 1109593 R 561275 CDS YP_002644077.1 224989390 7563451 complement(1110322..1110654) 1 NC_012207.1 hypothetical protein 1110654 7563451 JTY_1018 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644077.1 1110322 R 561275 CDS YP_002644078.1 224989391 7563452 complement(1110728..1111321) 1 NC_012207.1 Differs from Rv0992c by 2aa, I3M, S135G, and from Mb1019c by 1aa, S135G in BCG Pasteur and BCG Tokyo; hypothetical protein 1111321 7563452 JTY_1019 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644078.1 1110728 R 561275 CDS YP_002644079.1 224989392 7563453 1111422..1112342 1 NC_012207.1 Differs from Rv0993 by 1aa, R235Q in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; UTP--glucose-1-phosphate uridylyltransferase 1112342 galU 7563453 galU Mycobacterium bovis BCG str. Tokyo 172 UTP--glucose-1-phosphate uridylyltransferase YP_002644079.1 1111422 D 561275 CDS YP_002644080.1 224989393 7561901 1112419..1113699 1 NC_012207.1 Differs from Rv0994 by 1aa, G230C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; molybdopterin biosynthesis protein 1113699 moeA1 7561901 moeA1 Mycobacterium bovis BCG str. Tokyo 172 molybdopterin biosynthesis protein YP_002644080.1 1112419 D 561275 CDS YP_002644081.1 224989394 7563539 1113762..1114373 1 NC_012207.1 ribosomal-protein-alanine acetyltransferase 1114373 rimJ 7563539 rimJ Mycobacterium bovis BCG str. Tokyo 172 ribosomal-protein-alanine acetyltransferase YP_002644081.1 1113762 D 561275 CDS YP_002644082.1 224989395 7561579 1114534..1115610 1 NC_012207.1 Differs from Rv0996 by 1aa, D92G, and from Mb1023 by 1aa, D92G in BCG Pasteur, and BCG Tokyo; transmembrane protein 1115610 7561579 JTY_1023 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002644082.1 1114534 D 561275 CDS YP_002644083.1 224989396 7563957 1115784..1116014 1 NC_012207.1 hypothetical protein 1116014 7563957 JTY_1024 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644083.1 1115784 D 561275 CDS YP_002644084.1 224989397 7563455 1116011..1116262 1 NC_012207.1 hypothetical protein 1116262 7563455 JTY_1025 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644084.1 1116011 D 561275 CDS YP_002644085.1 224989398 7563456 1116443..1116874 1 NC_012207.1 hypothetical protein 1116874 7563456 JTY_1026 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644085.1 1116443 D 561275 CDS YP_002644086.1 224989399 7563457 1116898..1117899 1 NC_012207.1 hypothetical protein 1117899 7563457 JTY_1027 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644086.1 1116898 D 561275 CDS YP_002644087.1 224989400 7563458 1117917..1118675 1 NC_012207.1 hypothetical protein 1118675 7563458 JTY_1028 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644087.1 1117917 D 561275 CDS YP_002644088.1 224989401 7563459 complement(1118681..1119298) 1 NC_012207.1 hypothetical protein 1119298 7563459 JTY_1029 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644088.1 1118681 R 561275 CDS YP_002644089.1 224989402 7563460 1119335..1120543 1 NC_012207.1 catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 1120543 arcA 7563460 arcA Mycobacterium bovis BCG str. Tokyo 172 arginine deiminase YP_002644089.1 1119335 D 561275 CDS YP_002644090.1 224989403 7563982 complement(1120578..1122089) 1 NC_012207.1 Differs from Rv1002c by 1aa, L115V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; hypothetical protein 1122089 7563982 JTY_1031 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644090.1 1120578 R 561275 CDS YP_002644091.1 224989404 7563461 1122172..1123029 1 NC_012207.1 hypothetical protein 1123029 7563461 JTY_1032 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644091.1 1122172 D 561275 CDS YP_002644092.1 224989405 7563462 complement(1123039..1124298) 1 NC_012207.1 hypothetical protein 1124298 7563462 JTY_1033 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644092.1 1123039 R 561275 CDS YP_002644093.1 224989406 7563463 complement(1124372..1125808) 1 NC_012207.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; aminodeoxychorismate synthase component I 1125808 pabB 7563463 pabB Mycobacterium bovis BCG str. Tokyo 172 aminodeoxychorismate synthase component I YP_002644093.1 1124372 R 561275 CDS YP_002644094.1 224989407 7562507 1125864..1127567 1 NC_012207.1 Differs from Rv1006 by 1aa, S535P, and from Mb1033 by 1aa, N25S in BCG Pasteur and BCG Tokyo; hypothetical protein 1127567 7562507 JTY_1035 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644094.1 1125864 D 561275 CDS YP_002644095.1 224989408 7563464 complement(1127594..1129153) 1 NC_012207.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 1129153 metS 7563464 metS Mycobacterium bovis BCG str. Tokyo 172 methionyl-tRNA synthetase YP_002644095.1 1127594 R 561275 CDS YP_002644096.1 224989409 7564463 1129239..1130033 1 NC_012207.1 Differs from Rv1008 by 1aa, N186T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; YjjV protein; deoxyribonuclease 1130033 tatD 7564463 tatD Mycobacterium bovis BCG str. Tokyo 172 deoxyribonuclease YP_002644096.1 1129239 D 561275 CDS YP_002644097.1 224989410 7561826 1130241..1131329 1 NC_012207.1 Differs from Rv1009 by 2aa, E282G, V357A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; resuscitation-promoting factor 1131329 rpfB 7561826 rpfB Mycobacterium bovis BCG str. Tokyo 172 resuscitation-promoting factor YP_002644097.1 1130241 D 561275 CDS YP_002644098.1 224989411 7561597 1131302..1132255 1 NC_012207.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1132255 ksgA 7561597 ksgA Mycobacterium bovis BCG str. Tokyo 172 dimethyladenosine transferase YP_002644098.1 1131302 D 561275 CDS YP_002644099.1 224989412 7562809 1132341..1133261 1 NC_012207.1 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1133261 ispE 7562809 ispE Mycobacterium bovis BCG str. Tokyo 172 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_002644099.1 1132341 D 561275 CDS YP_002644100.1 224989413 7562795 1133258..1133572 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1012 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-G) leads to a different NH2 terminus. Differs from Rv1012 by 1aa, N65S; hypothetical protein 1133572 7562795 JTY_1041 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644100.1 1133258 D 561275 CDS YP_002644101.1 224989414 7563465 1133776..1135410 1 NC_012207.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1135410 pks16 7563465 pks16 Mycobacterium bovis BCG str. Tokyo 172 long-chain-fatty-acid--CoA ligase YP_002644101.1 1133776 D 561275 CDS YP_002644102.1 224989415 7562445 complement(1135484..1136059) 1 NC_012207.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1136059 pth 7562445 pth Mycobacterium bovis BCG str. Tokyo 172 peptidyl-tRNA hydrolase YP_002644102.1 1135484 R 561275 CDS YP_002644103.1 224989416 7560851 complement(1136072..1136719) 1 NC_012207.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 1136719 rplY 7560851 rplY Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L25 YP_002644103.1 1136072 R 561275 CDS YP_002644104.1 224989417 7560712 complement(1136853..1137611) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a 5 bp deletion (CACGC-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; lipoprotein 1137611 lpqT 7560712 lpqT Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644104.1 1136853 R 561275 CDS YP_002644105.1 224989418 7560512 complement(1137647..1138627) 1 NC_012207.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1138627 prsA 7560512 prsA Mycobacterium bovis BCG str. Tokyo 172 ribose-phosphate pyrophosphokinase YP_002644105.1 1137647 R 561275 CDS YP_002644106.1 224989419 7560837 complement(1138719..1140206) 1 NC_012207.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 1140206 glmU 7560837 glmU Mycobacterium bovis BCG str. Tokyo 172 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_002644106.1 1138719 R 561275 CDS YP_002644107.1 224989420 7561935 1140461..1141054 1 NC_012207.1 probably TetR-family; transcriptional regulatory protein 1141054 7561935 JTY_1048 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644107.1 1140461 D 561275 CDS YP_002644108.1 224989421 7563466 1141113..1144817 1 NC_012207.1 transcription-repair coupling factor 1144817 mfd 7563466 mfd Mycobacterium bovis BCG str. Tokyo 172 transcription-repair coupling factor YP_002644108.1 1141113 D 561275 CDS YP_002644109.1 224989422 7564470 1144817..1145794 1 NC_012207.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 1145794 7564470 JTY_1050 Mycobacterium bovis BCG str. Tokyo 172 nucleoside triphosphate pyrophosphohydrolase YP_002644109.1 1144817 D 561275 CDS YP_002644110.1 224989423 7563467 1145882..1146613 1 NC_012207.1 Differs from Rv1022 by 1aa, P33T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 1146613 lpqU 7563467 lpqU Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644110.1 1145882 D 561275 CDS YP_002644111.1 224989424 7560513 1146710..1147999 1 NC_012207.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1147999 eno 7560513 eno Mycobacterium bovis BCG str. Tokyo 172 phosphopyruvate hydratase YP_002644111.1 1146710 D 561275 CDS YP_002644112.1 224989425 7562865 1148004..1148690 1 NC_012207.1 hypothetical protein 1148690 7562865 JTY_1053 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644112.1 1148004 D 561275 CDS YP_002644113.1 224989426 7563468 1148707..1149174 1 NC_012207.1 hypothetical protein 1149174 7563468 JTY_1054 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644113.1 1148707 D 561275 CDS YP_002644114.1 224989427 7563469 1149165..1150124 1 NC_012207.1 hypothetical protein 1150124 7563469 JTY_1055 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644114.1 1149165 D 561275 CDS YP_002644115.1 224989428 7563470 complement(1150573..1151253) 1 NC_012207.1 transcriptional regulatory protein 1151253 kdpE 7563470 kdpE Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644115.1 1150573 R 561275 CDS YP_002644116.1 224989429 7562805 complement(1151250..1153832) 1 NC_012207.1 Differs from Rv1028c by 3aa, S83P, D295G, S368P, and from Mb1056c by 1aa, S83P in BCG Pasteur and BCG Tokyo; sensor protein 1153832 kdpD 7562805 kdpD Mycobacterium bovis BCG str. Tokyo 172 sensor protein YP_002644116.1 1151250 R 561275 CDS YP_002644117.1 224989430 7562804 1154066..1154158 1 NC_012207.1 hypothetical protein 1154158 kdpF 7562804 kdpF Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644117.1 1154066 D 561275 CDS YP_002644118.1 224989431 7562806 1154158..1155873 1 NC_012207.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 1155873 kdpA 7562806 kdpA Mycobacterium bovis BCG str. Tokyo 172 potassium-transporting ATPase subunit A YP_002644118.1 1154158 D 561275 CDS YP_002644119.1 224989432 7562801 1155870..1157999 1 NC_012207.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 1157999 kdpB 7562801 kdpB Mycobacterium bovis BCG str. Tokyo 172 potassium-transporting ATPase subunit B YP_002644119.1 1155870 D 561275 CDS YP_002644120.1 224989433 7562802 1157999..1158568 1 NC_012207.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 1158568 kdpC 7562802 kdpC Mycobacterium bovis BCG str. Tokyo 172 potassium-transporting ATPase subunit C YP_002644120.1 1157999 D 561275 CDS YP_002644121.1 224989434 7562803 complement(1158572..1160101) 1 NC_012207.1 two component sensor histidine kinase 1160101 trcS 7562803 trcS Mycobacterium bovis BCG str. Tokyo 172 two component sensor histidine kinase YP_002644121.1 1158572 R 561275 CDS YP_002644122.1 224989435 7561867 complement(1160109..1160882) 1 NC_012207.1 two component transcriptional regulator 1160882 trcR 7561867 trcR Mycobacterium bovis BCG str. Tokyo 172 two component transcriptional regulator YP_002644122.1 1160109 R 561275 CDS YP_002644123.1 224989436 7561866 complement(1161064..1161453) 1 NC_012207.1 transposase 1161453 7561866 JTY_1064 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002644123.1 1161064 R 561275 CDS YP_002644124.1 224989437 7563471 complement(1161521..1162207) 1 NC_012207.1 transposase 1162207 7563471 JTY_1065 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002644124.1 1161521 R 561275 CDS YP_002644125.1 224989438 7563472 complement(1162241..1162579) 1 NC_012207.1 IS1560 transposase 1162579 7563472 JTY_1066 Mycobacterium bovis BCG str. Tokyo 172 IS1560 transposase YP_002644125.1 1162241 R 561275 CDS YP_002644126.1 224989439 7563473 complement(1162690..1162974) 1 NC_012207.1 Differs from Rv1037c by 1aa, L20Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; EsaT-6 like protein 1 1162974 esxI 7563473 esxI Mycobacterium bovis BCG str. Tokyo 172 EsaT-6 like protein 1 YP_002644126.1 1162690 R 561275 CDS YP_002644127.1 224989440 7562880 complement(1163001..1163297) 1 NC_012207.1 EsaT-6 like protein 2 1163297 esxJ 7562880 esxJ Mycobacterium bovis BCG str. Tokyo 172 EsaT-6 like protein 2 YP_002644127.1 1163001 R 561275 CDS YP_002644128.1 224989441 7562881 complement(1163443..1164618) 1 NC_012207.1 Differs from Rv1039c and Mb1068c by 1aa, K175N in BCG Pasteur and BCG Tokyo; PPE family protein 1164618 PPE15 7562881 PPE15 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644128.1 1163443 R 561275 CDS YP_002644129.1 224989442 7562150 complement(1164695..1165522) 1 NC_012207.1 PE family protein 1165522 PE8 7562150 PE8 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002644129.1 1164695 R 561275 CDS YP_002644130.1 224989443 7563474 complement(1167238..1167645) 1 NC_012207.1 Differs from Rv1042c by 1aa, E129G in Mycobacterium bovis and BCG Pasteur. Differs from Mb1070c by G129E in Mycobacterium tuberculosis and Mycobacterium bovis BCG Tokyo; IS like-2 transposase 1167645 7563474 JTY_1072 Mycobacterium bovis BCG str. Tokyo 172 IS like-2 transposase YP_002644130.1 1167238 R 561275 CDS YP_002644131.1 224989444 7563475 complement(1167928..1168953) 1 NC_012207.1 Differs from Rv1043c by 1aa, T99A, and from Mb1072c by 1aa, G263C in BCG Pasteur and BCG Tokyo; hypothetical protein 1168953 7563475 JTY_1073 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644131.1 1167928 R 561275 CDS YP_002644132.1 224989445 7563476 1169200..1169823 1 NC_012207.1 hypothetical protein 1169823 7563476 JTY_1074 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644132.1 1169200 D 561275 CDS YP_002644133.1 224989446 7563477 1169820..1170701 1 NC_012207.1 Differs from Mb1074 by 1aa, W104G in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein 1170701 7563477 JTY_1075 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644133.1 1169820 D 561275 CDS YP_002644134.1 224989447 7563478 complement(1170783..1171376) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 1bp insertion, compared to Mycobacterium tuberculosis strains H37Rv, leads to different C-terminus; hypothetical protein 1171376 7563478 JTY_1076 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644134.1 1170783 R 561275 CDS YP_002644135.1 224989448 7563479 1171571..1172818 1 NC_012207.1 IS1081 transposase 1172818 7563479 JTY_1077 Mycobacterium bovis BCG str. Tokyo 172 IS1081 transposase YP_002644135.1 1171571 D 561275 CDS YP_002644136.1 224989449 7563480 complement(1173186..1174301) 1 NC_012207.1 Differs from Rv1048c and Mb1077c by 2aa, A37D, T173A in BCG Pasteur and BCG Tokyo.; hypothetical protein 1174301 7563480 JTY_1078 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644136.1 1173186 R 561275 CDS YP_002644137.1 224989450 7563481 1174534..1174980 1 NC_012207.1 transcriptional repressor protein 1174980 7563481 JTY_1079 Mycobacterium bovis BCG str. Tokyo 172 transcriptional repressor protein YP_002644137.1 1174534 D 561275 CDS YP_002644138.1 224989451 7563482 1175028..1175933 1 NC_012207.1 oxidoreductase 1175933 7563482 JTY_1080 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002644138.1 1175028 D 561275 CDS YP_002644139.1 224989452 7563483 complement(1176092..1176847) 1 NC_012207.1 hypothetical protein 1176847 7563483 JTY_1081 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644139.1 1176092 R 561275 CDS YP_002644140.1 224989453 7563484 1177870..1178259 1 NC_012207.1 hypothetical protein 1178259 7563484 JTY_1082 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644140.1 1177870 D 561275 CDS YP_002644141.1 224989454 7563485 complement(1178158..1178433) 1 NC_012207.1 hypothetical protein 1178433 7563485 JTY_1083 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644141.1 1178158 R 561275 CDS YP_002644142.1 224989455 7563486 1179075..1179389 1 NC_012207.1 integrase 1179389 7563486 JTY_1084 Mycobacterium bovis BCG str. Tokyo 172 integrase YP_002644142.1 1179075 D 561275 CDS YP_002644143.1 224989456 7563487 1179386..1179520 1 NC_012207.1 integrase 1179520 7563487 JTY_1085 Mycobacterium bovis BCG str. Tokyo 172 integrase YP_002644143.1 1179386 D 561275 CDS YP_002644144.1 224989457 7562822 1179775..1180539 1 NC_012207.1 hypothetical protein 1180539 7562822 JTY_1086 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644144.1 1179775 D 561275 CDS YP_002644145.1 224989458 7563489 1181543..1182724 1 NC_012207.1 hypothetical protein 1182724 7563489 JTY_1087 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644145.1 1181543 D 561275 CDS YP_002644146.1 224989459 7563490 1182831..1184462 1 NC_012207.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1184462 fadD14 7563490 fadD14 Mycobacterium bovis BCG str. Tokyo 172 long-chain-fatty-acid--CoA ligase YP_002644146.1 1182831 D 561275 CDS YP_002644147.1 224989460 7562920 1184538..1185602 1 NC_012207.1 hypothetical protein 1185602 7562920 JTY_1089 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644147.1 1184538 D 561275 CDS YP_002644148.1 224989461 7563491 1185655..1186128 1 NC_012207.1 hypothetical protein 1186128 7563491 JTY_1090 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644148.1 1185655 D 561275 CDS YP_002644149.1 224989462 7563492 1186162..1187025 1 NC_012207.1 hypothetical protein 1187025 7563492 JTY_1091 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644149.1 1186162 D 561275 CDS YP_002644150.1 224989463 7563493 1187030..1187887 1 NC_012207.1 hypothetical protein 1187887 7563493 JTY_1092 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644150.1 1187030 D 561275 CDS YP_002644151.1 224989464 7563494 complement(1187888..1188970) 1 NC_012207.1 hypothetical protein 1188970 7563494 JTY_1093 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644151.1 1187888 R 561275 CDS YP_002644152.1 224989465 7563495 complement(1189051..1189470) 1 NC_012207.1 lipoprotein 1189470 lpqV 7563495 lpqV Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644152.1 1189051 R 561275 CDS YP_002644153.1 224989466 7560514 1189582..1190148 1 NC_012207.1 hypothetical protein 1190148 7560514 JTY_1095 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644153.1 1189582 D 561275 CDS YP_002644154.1 224989467 7563496 1190145..1190540 1 NC_012207.1 hypothetical protein 1190540 7563496 JTY_1096 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644154.1 1190145 D 561275 CDS YP_002644155.1 224989468 7563497 complement(1190568..1192583) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, 2 deletions each of 3 bp (CCG-* and CGC-*) and a 18 bp insertion leads to a longer product compared to their homolog in Mycobacterium tuberculosis strain H37Rv (671 aa versus 667 aa); PE-PGRS family protein 1192583 PE_PGRS19 7563497 PE_PGRS19 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644155.1 1190568 R 561275 CDS YP_002644156.1 224989469 7561758 complement(1192916..1193530) 1 NC_012207.1 In Mycobacterium bovis, insertions of 717 bp and 192 bp, and a 9 bp (TCCGCTGCC-*) deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (763 aa versus 463 aa). In Mycobacterium bovis BCG Pasteur a deletion of 99 bp leads to a smaller product compared to the homolog in Mycobacterium bovis (730 aa versus 763 aa). Mycobacterium bovis BCG Tokyo a deletion of 323 bp from BCG Pasteur leads to two products (204 aa, 401 aa); PE-PGRS family protein 1193530 PE_PGRS20.1 7561758 PE_PGRS20.1 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644156.1 1192916 R 561275 CDS YP_002644157.1 224989470 7561760 complement(1193553..1194758) 1 NC_012207.1 In Mycobacterium bovis, insertions of 717 bp and 192 bp, and a 9 bp (tccgctgcc-*) deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (763 aa versus 463 aa). In Mycobacterium bovis BCG Pasteur a deletion of 99 bp leads to a smaller product compared to the homolog in Mycobacterium bovis (730 aa versus 763 aa). Mycobacterium bovis BCG Tokyo a deletion of 323 bp from BCG Pasteur leads to two products (204 aa, 401 aa); PE-PGRS family protein 1194758 PE_PGRS20.2 7561760 PE_PGRS20.2 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644157.1 1193553 R 561275 CDS YP_002644158.1 224989471 7561761 complement(1195147..1196910) 1 NC_012207.1 Differs from Rv1069c and from Mb1098c by 1aa L481P in BCG Pasteur and BCG Tokyo.; hypothetical protein 1196910 7561761 JTY_1100 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644158.1 1195147 R 561275 CDS YP_002644159.1 224989472 7563498 complement(1196907..1197680) 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1197680 echA8 7563498 echA8 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002644159.1 1196907 R 561275 CDS YP_002644160.1 224989473 7561539 complement(1197692..1198729) 1 NC_012207.1 catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; 3-hydroxyisobutyryl-CoA hydrolase 1198729 echA9 7561539 echA9 Mycobacterium bovis BCG str. Tokyo 172 3-hydroxyisobutyryl-CoA hydrolase YP_002644160.1 1197692 R 561275 CDS YP_002644161.1 224989474 7561540 1198916..1199752 1 NC_012207.1 transmembrane protein 1199752 7561540 JTY_1103 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002644161.1 1198916 D 561275 CDS YP_002644162.1 224989475 7563499 1199868..1200719 1 NC_012207.1 hypothetical protein 1200719 7563499 JTY_1104 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644162.1 1199868 D 561275 CDS YP_002644163.1 224989476 7563500 complement(1200793..1202010) 1 NC_012207.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 1202010 fadA3 7563500 fadA3 Mycobacterium bovis BCG str. Tokyo 172 acetyl-CoA acetyltransferase YP_002644163.1 1200793 R 561275 CDS YP_002644164.1 224989477 7562906 complement(1202063..1203007) 1 NC_012207.1 conserved exported protein 1203007 7562906 JTY_1106 Mycobacterium bovis BCG str. Tokyo 172 conserved exported protein YP_002644164.1 1202063 R 561275 CDS YP_002644165.1 224989478 7563501 1203404..1204297 1 NC_012207.1 lipase 1204297 lipU 7563501 lipU Mycobacterium bovis BCG str. Tokyo 172 lipase YP_002644165.1 1203404 D 561275 CDS YP_002644166.1 224989479 7562847 1204354..1205748 1 NC_012207.1 cystathionine beta-synthase 1205748 cbs 7562847 cbs Mycobacterium bovis BCG str. Tokyo 172 cystathionine beta-synthase YP_002644166.1 1204354 D 561275 CDS YP_002644167.1 224989480 7562084 1205950..1206672 1 NC_012207.1 Differs from Rv1078 by 1aa T171I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; proline-rich antigen homolog 1206672 pra 7562084 pra Mycobacterium bovis BCG str. Tokyo 172 proline-rich antigen homolog YP_002644167.1 1205950 D 561275 CDS YP_002644168.1 224989481 7560818 1206704..1207870 1 NC_012207.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 1207870 metB 7560818 metB Mycobacterium bovis BCG str. Tokyo 172 cystathionine gamma-synthase YP_002644168.1 1206704 D 561275 CDS YP_002644169.1 224989482 7564458 complement(1207941..1208435) 1 NC_012207.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1208435 greA 7564458 greA Mycobacterium bovis BCG str. Tokyo 172 transcription elongation factor GreA YP_002644169.1 1207941 R 561275 CDS YP_002644170.1 224989483 7563281 complement(1208621..1209055) 1 NC_012207.1 hypothetical protein 1209055 7563281 JTY_1112 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644170.1 1208621 R 561275 CDS YP_002644171.1 224989484 7563502 1209157..1210023 1 NC_012207.1 mycothiol conjugate amidase 1210023 mca 7563502 mca Mycobacterium bovis BCG str. Tokyo 172 mycothiol conjugate amidase YP_002644171.1 1209157 D 561275 CDS YP_002644172.1 224989485 7564431 1210020..1210286 1 NC_012207.1 hypothetical protein 1210286 7564431 JTY_1114 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644172.1 1210020 D 561275 CDS YP_002644173.1 224989486 7563503 1210273..1212294 1 NC_012207.1 hypothetical protein 1212294 7563503 JTY_1115 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644173.1 1210273 D 561275 CDS YP_002644174.1 224989487 7563504 complement(1212393..1213121) 1 NC_012207.1 hemolysin-like protein 1213121 7563504 JTY_1116 Mycobacterium bovis BCG str. Tokyo 172 hemolysin-like protein YP_002644174.1 1212393 R 561275 CDS YP_002644175.1 224989488 7563505 1213232..1214020 1 NC_012207.1 short (C15) chain Z-isoprenyl diphosphate synthase 1214020 7563505 JTY_1117 Mycobacterium bovis BCG str. Tokyo 172 short (C15) chain Z-isoprenyl diphosphate synthase YP_002644175.1 1213232 D 561275 CDS YP_002644176.1 224989489 7563506 1214197..1216626 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur and Tokyo, insertions of 144 bp and 3 bp, and deletion of 42 bp, lead to a longer product compared to the homolog in Mycobacterium bovis (809 aa versus 774 aa). In Mycobacterium bovis, insertions of 3 bp (*-GCG) and 45 bp, and deletions of 18 bp and 9 bp (GGTGGGGCC-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (774 aa versus 767 aa); PE-PGRS family protein 1216626 PE_PGRS21 7563506 PE_PGRS21 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644176.1 1214197 D 561275 CDS YP_002644177.1 224989490 7561762 1216803..1217123 1 NC_012207.1 hypothetical protein 1217123 7561762 JTY_1119 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644177.1 1216803 D 561275 CDS YP_002644178.1 224989491 7563507 1217276..1217710 1 NC_012207.1 PE family protein 1217710 PE9 7563507 PE9 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002644178.1 1217276 D 561275 CDS YP_002644179.1 224989492 7561740 1217589..1217894 1 NC_012207.1 Differs from Rv1089 and Mb1118 by 1 aa N84T in BCG Pasteur and BCG Tokyo; PE family protein 1217894 PE10 7561740 PE10 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002644179.1 1217589 D 561275 CDS YP_002644180.1 224989493 7561710 1218280..1218384 1 NC_012207.1 cellulase 1218384 celA2a 7561710 celA2a Mycobacterium bovis BCG str. Tokyo 172 cellulase YP_002644180.1 1218280 D 561275 CDS YP_002644181.1 224989494 7562093 1218362..1218817 1 NC_012207.1 cellulase 1218817 celA2b 7562093 celA2b Mycobacterium bovis BCG str. Tokyo 172 cellulase YP_002644181.1 1218362 D 561275 CDS YP_002644182.1 224989495 7562094 1219232..1221784 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 9 bp deletion (CCGGCGGCA-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (850 aa versus 853 aa); PE-PGRS family protein 1221784 PE_PGRS22 7562094 PE_PGRS22 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644182.1 1219232 D 561275 CDS YP_002644183.1 224989496 7561763 complement(1222002..1222940) 1 NC_012207.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 1222940 coaA 7561763 coaA Mycobacterium bovis BCG str. Tokyo 172 pantothenate kinase YP_002644183.1 1222002 R 561275 CDS YP_002644184.1 224989497 7562117 1223328..1224608 1 NC_012207.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 1224608 glyA 7562117 glyA Mycobacterium bovis BCG str. Tokyo 172 serine hydroxymethyltransferase YP_002644184.1 1223328 D 561275 CDS YP_002644185.1 224989498 7561952 1224713..1225540 1 NC_012207.1 acyl-ACP desaturase 1225540 desA2 7561952 desA2 Mycobacterium bovis BCG str. Tokyo 172 acyl-ACP desaturase YP_002644185.1 1224713 D 561275 CDS YP_002644186.1 224989499 7561484 1225751..1227052 1 NC_012207.1 phoH-like protein 1227052 phoH2 7561484 phoH2 Mycobacterium bovis BCG str. Tokyo 172 phoH-like protein YP_002644186.1 1225751 D 561275 CDS YP_002644187.1 224989500 7562410 1227139..1228014 1 NC_012207.1 Differs from Rv1096 by 1aa, S272P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; glycosyl hydrolase 1228014 7562410 JTY_1129 Mycobacterium bovis BCG str. Tokyo 172 glycosyl hydrolase YP_002644187.1 1227139 D 561275 CDS YP_002644188.1 224989501 7563508 complement(1228017..1228898) 1 NC_012207.1 Differs from Rv1097c by 1aa, L23P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; membrane glycine and proline rich protein 1228898 7563508 JTY_1130 Mycobacterium bovis BCG str. Tokyo 172 membrane glycine and proline rich protein YP_002644188.1 1228017 R 561275 CDS YP_002644189.1 224989502 7563509 complement(1228895..1230319) 1 NC_012207.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1230319 fumC 7563509 fumC Mycobacterium bovis BCG str. Tokyo 172 fumarate hydratase YP_002644189.1 1228895 R 561275 CDS YP_002644190.1 224989503 7561885 complement(1230350..1231336) 1 NC_012207.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 1231336 glpX 7561885 glpX Mycobacterium bovis BCG str. Tokyo 172 fructose 1,6-bisphosphatase II YP_002644190.1 1230350 R 561275 CDS YP_002644191.1 224989504 7561944 1231437..1232138 1 NC_012207.1 Differs from Rv1100 and Mb1130 by 1aa, P21T in BCG Pasteur and BCG Tokyo; hypothetical protein 1232138 7561944 JTY_1133 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644191.1 1231437 D 561275 CDS YP_002644192.1 224989505 7563510 complement(1232145..1233173) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (T-*) leads to a shorter product with a different amino part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Mb1131c by 1 aa, E315D in BCG Pasteur and BCG Tokyo; hypothetical protein 1233173 7563510 JTY_1134 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644192.1 1232145 R 561275 CDS YP_002644193.1 224989506 7563511 complement(1233413..1233724) 1 NC_012207.1 Differs from Rv1102c by 1aa, I65T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1233724 7563511 JTY_1135 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644193.1 1233413 R 561275 CDS YP_002644194.1 224989507 7562528 complement(1233724..1234044) 1 NC_012207.1 hypothetical protein 1234044 7562528 JTY_1136 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644194.1 1233724 R 561275 CDS YP_002644195.1 224989508 7562529 1234054..1234743 1 NC_012207.1 para-nitrobenzyl esterase 1234743 7562529 JTY_1137 Mycobacterium bovis BCG str. Tokyo 172 para-nitrobenzyl esterase YP_002644195.1 1234054 D 561275 CDS YP_002644196.1 224989509 7562530 1235064..1235579 1 NC_012207.1 para-nitrobenzyl esterase 1235579 7562530 JTY_1138 Mycobacterium bovis BCG str. Tokyo 172 para-nitrobenzyl esterase YP_002644196.1 1235064 D 561275 CDS YP_002644197.1 224989510 7562531 complement(1235597..1236709) 1 NC_012207.1 cholesterol dehydrogenase 1236709 7562531 JTY_1139 Mycobacterium bovis BCG str. Tokyo 172 cholesterol dehydrogenase YP_002644197.1 1235597 R 561275 CDS YP_002644198.1 224989511 7562532 complement(1236719..1236976) 1 NC_012207.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 1236976 xseB 7562532 xseB Mycobacterium bovis BCG str. Tokyo 172 exodeoxyribonuclease VII small subunit YP_002644198.1 1236719 R 561275 CDS YP_002644199.1 224989512 7561699 complement(1236966..1238213) 1 NC_012207.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 1238213 xseA 7561699 xseA Mycobacterium bovis BCG str. Tokyo 172 exodeoxyribonuclease VII large subunit YP_002644199.1 1236966 R 561275 CDS YP_002644200.1 224989513 7561698 complement(1238210..1238848) 1 NC_012207.1 Differs from Rv1109c and Mb1139c by 1aa, T147A in BCG Pasteur and BCG Tokyo; hypothetical protein 1238848 7561698 JTY_1142 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644200.1 1238210 R 561275 CDS YP_002644201.1 224989514 7562533 1238938..1239945 1 NC_012207.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1239945 ispH 7562533 ispH Mycobacterium bovis BCG str. Tokyo 172 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_002644201.1 1238938 D 561275 CDS YP_002644202.1 224989515 7560545 complement(1239962..1240945) 1 NC_012207.1 hypothetical protein 1240945 7560545 JTY_1144 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644202.1 1239962 R 561275 CDS YP_002644203.1 224989516 7562534 1241008..1242081 1 NC_012207.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1242081 ychF 7562534 ychF Mycobacterium bovis BCG str. Tokyo 172 GTP-dependent nucleic acid-binding protein EngD YP_002644203.1 1241008 D 561275 CDS YP_002644204.1 224989517 7561703 1242169..1242366 1 NC_012207.1 hypothetical protein 1242366 7561703 JTY_1146 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644204.1 1242169 D 561275 CDS YP_002644205.1 224989518 7562535 1242363..1242737 1 NC_012207.1 hypothetical protein 1242737 7562535 JTY_1147 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644205.1 1242363 D 561275 CDS YP_002644206.1 224989519 7562536 1242940..1243638 1 NC_012207.1 Differs from Rv1115 by 1aa, P19S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1243638 7562536 JTY_1148 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644206.1 1242940 D 561275 CDS YP_002644207.1 224989520 7562537 1243756..1243941 1 NC_012207.1 hypothetical protein 1243941 7562537 JTY_1149 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644207.1 1243756 D 561275 CDS YP_002644208.1 224989521 7562538 complement(1243868..1244143) 1 NC_012207.1 hypothetical protein 1244143 7562538 JTY_1150 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644208.1 1243868 R 561275 CDS YP_002644209.1 224989522 7562539 1244386..1244709 1 NC_012207.1 hypothetical protein 1244709 7562539 JTY_1151 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644209.1 1244386 D 561275 CDS YP_002644210.1 224989523 7562540 complement(1244724..1245584) 1 NC_012207.1 hypothetical protein 1245584 7562540 JTY_1152 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644210.1 1244724 R 561275 CDS YP_002644211.1 224989524 7562541 complement(1245617..1245766) 1 NC_012207.1 hypothetical protein 1245766 7562541 JTY_1153 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644211.1 1245617 R 561275 CDS YP_002644212.1 224989525 7562542 complement(1245763..1246257) 1 NC_012207.1 Differs from Mb1151c by 1aa, G53A in BCG Pasteur and BCG Tokyo; hypothetical protein 1246257 7562542 JTY_1154 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644212.1 1245763 R 561275 CDS YP_002644213.1 224989526 7562543 1246460..1247860 1 NC_012207.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1247860 zwf1 7562543 zwf1 Mycobacterium bovis BCG str. Tokyo 172 glucose-6-phosphate 1-dehydrogenase YP_002644213.1 1246460 D 561275 CDS YP_002644214.1 224989527 7561457 1247882..1248904 1 NC_012207.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; 6-phosphogluconate dehydrogenase 1248904 gnd2 7561457 gnd2 Mycobacterium bovis BCG str. Tokyo 172 6-phosphogluconate dehydrogenase YP_002644214.1 1247882 D 561275 CDS YP_002644215.1 224989528 7563273 complement(1248897..1249805) 1 NC_012207.1 non-haem peroxidase; peroxidase 1249805 bpoB 7563273 bpoB Mycobacterium bovis BCG str. Tokyo 172 peroxidase YP_002644215.1 1248897 R 561275 CDS YP_002644216.1 224989529 7562077 1249880..1250830 1 NC_012207.1 epoxide hydrolase 1250830 ephC 7562077 ephC Mycobacterium bovis BCG str. Tokyo 172 epoxide hydrolase YP_002644216.1 1249880 D 561275 CDS YP_002644217.1 224989530 7562868 1250835..1252079 1 NC_012207.1 Differs from Rv1125 by 1aa, G101S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1252079 7562868 JTY_1159 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644217.1 1250835 D 561275 CDS YP_002644218.1 224989531 7562544 complement(1252083..1252688) 1 NC_012207.1 hypothetical protein 1252688 7562544 JTY_1160 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644218.1 1252083 R 561275 CDS YP_002644219.1 224989532 7562545 complement(1252685..1254157) 1 NC_012207.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 1254157 ppdK 7562545 ppdK Mycobacterium bovis BCG str. Tokyo 172 pyruvate phosphate dikinase YP_002644219.1 1252685 R 561275 CDS YP_002644220.1 224989533 7562143 complement(1254370..1255725) 1 NC_012207.1 Differs from Rv1128c by 1aa, G270E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1255725 7562143 JTY_1162 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644220.1 1254370 R 561275 CDS YP_002644221.1 224989534 7562546 complement(1255827..1257287) 1 NC_012207.1 transcriptional regulator protein 1257287 7562546 JTY_1163 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulator protein YP_002644221.1 1255827 R 561275 CDS YP_002644222.1 224989535 7562547 1257308..1258888 1 NC_012207.1 Differs from Rv1130 by 2aa, G3D, L10F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1258888 7562547 JTY_1164 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644222.1 1257308 D 561275 CDS YP_002644223.1 224989536 7562548 1258885..1260066 1 NC_012207.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; citrate synthase 1260066 gltA1 7562548 gltA1 Mycobacterium bovis BCG str. Tokyo 172 citrate synthase YP_002644223.1 1258885 D 561275 CDS YP_002644224.1 224989537 7561946 1260078..1261808 1 NC_012207.1 Differs from Mb1163 by 1aa, T176M in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1261808 7561946 JTY_1166 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644224.1 1260078 D 561275 CDS YP_002644225.1 224989538 7562549 complement(1261820..1264099) 1 NC_012207.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 1264099 metE 7562549 metE Mycobacterium bovis BCG str. Tokyo 172 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase YP_002644225.1 1261820 R 561275 CDS YP_002644226.1 224989539 7564460 1264675..1264911 1 NC_012207.1 hypothetical protein 1264911 7564460 JTY_1168 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644226.1 1264675 D 561275 CDS YP_002644227.1 224989540 7562550 complement(1265025..1266881) 1 NC_012207.1 PPE family protein 1266881 PPE16 7562550 PPE16 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644227.1 1265025 R 561275 CDS YP_002644228.1 224989541 7562151 1267067..1267309 1 NC_012207.1 acetyl-CoA acetyltransferase 1267309 7562151 JTY_1170 Mycobacterium bovis BCG str. Tokyo 172 acetyl-CoA acetyltransferase YP_002644228.1 1267067 D 561275 CDS YP_002644229.1 224989542 7562551 1267359..1267700 1 NC_012207.1 enoyl-CoA hydratase 1267700 7562551 JTY_1171 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002644229.1 1267359 D 561275 CDS YP_002644230.1 224989543 7562552 complement(1267840..1268208) 1 NC_012207.1 hypothetical protein 1268208 7562552 JTY_1172 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644230.1 1267840 R 561275 CDS YP_002644231.1 224989544 7562553 complement(1268225..1269241) 1 NC_012207.1 oxidoreductase 1269241 7562553 JTY_1173 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002644231.1 1268225 R 561275 CDS YP_002644232.1 224989545 7562554 complement(1269238..1269738) 1 NC_012207.1 hypothetical protein 1269738 7562554 JTY_1174 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644232.1 1269238 R 561275 CDS YP_002644233.1 224989546 7562555 1270100..1270948 1 NC_012207.1 integral membrane protein 1270948 7562555 JTY_1175 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002644233.1 1270100 D 561275 CDS YP_002644234.1 224989547 7562556 complement(1270956..1271762) 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1271762 echA11 7562556 echA11 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002644234.1 1270956 R 561275 CDS YP_002644235.1 224989548 7561523 complement(1271905..1272711) 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1272711 echA10 7561523 echA10 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002644235.1 1271905 R 561275 CDS YP_002644236.1 224989549 7561522 1272815..1273897 1 NC_012207.1 alpha-methylacyl-CoA racemase 1273897 mcr 7561522 mcr Mycobacterium bovis BCG str. Tokyo 172 alpha-methylacyl-CoA racemase YP_002644236.1 1272815 D 561275 CDS YP_002644237.1 224989550 7564447 1273909..1274661 1 NC_012207.1 short-chain type dehydrogenase/reductase 1274661 7564447 JTY_1179 Mycobacterium bovis BCG str. Tokyo 172 short-chain type dehydrogenase/reductase YP_002644237.1 1273909 D 561275 CDS YP_002644238.1 224989551 7562557 1275176..1277521 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1145 and Rv1146 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-A) at H37Rv position 1273250-1273251 leads to a single product; transmembrane transport protein 1277521 mmpL13 7562557 mmpL13 Mycobacterium bovis BCG str. Tokyo 172 transmembrane transport protein YP_002644238.1 1275176 D 561275 CDS YP_002644239.1 224989552 7564483 1277654..1278304 1 NC_012207.1 hypothetical protein 1278304 7564483 JTY_1181 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644239.1 1277654 D 561275 CDS YP_002644240.1 224989553 7562558 complement(1279054..1280502) 1 NC_012207.1 Differs from Rv1148c and Mb1179c by 1aa, N354H in BCG Pasteur and BCG Tokyo; hypothetical protein 1280502 7562558 JTY_1182 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644240.1 1279054 R 561275 CDS YP_002644241.1 224989554 7562559 1280647..1281054 1 NC_012207.1 transposase 1281054 7562559 JTY_1183 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002644241.1 1280647 D 561275 CDS YP_002644242.1 224989555 7562561 complement(1281658..1282371) 1 NC_012207.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1282371 7562561 JTY_1185 Mycobacterium bovis BCG str. Tokyo 172 NAD-dependent deacetylase YP_002644242.1 1281658 R 561275 CDS YP_002644243.1 224989556 7562562 1282409..1282774 1 NC_012207.1 transcriptional regulatory protein 1282774 7562562 JTY_1186 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644243.1 1282409 D 561275 CDS YP_002644244.1 224989557 7562563 complement(1282752..1283600) 1 NC_012207.1 Differs from Rv1153c by 2aa, T36A, G53D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; O-methyltransferase 1283600 omt 7562563 omt Mycobacterium bovis BCG str. Tokyo 172 O-methyltransferase YP_002644244.1 1282752 R 561275 CDS YP_002644245.1 224989558 7562494 complement(1283597..1284238) 1 NC_012207.1 Differs from Rv1154c by 1aa, A123T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1284238 7562494 JTY_1188 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644245.1 1283597 R 561275 CDS YP_002644246.1 224989559 7562564 1284183..1284626 1 NC_012207.1 Differs from Rv1155 by 1aa, P115S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1284626 7562564 JTY_1189 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644246.1 1284183 D 561275 CDS YP_002644247.1 224989560 7562565 1285060..1285647 1 NC_012207.1 hypothetical protein 1285647 7562565 JTY_1190 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644247.1 1285060 D 561275 CDS YP_002644248.1 224989561 7562566 complement(1285810..1286853) 1 NC_012207.1 Is 24 codons shorter than Rv1157c and Mb1188c due to 72bp deletion at position equivalent to H37Rv, 1283458-1283529. After codon 214; hypothetical ala-, pro-rich protein 1286853 7562566 JTY_1191 Mycobacterium bovis BCG str. Tokyo 172 hypothetical ala-, pro-rich protein YP_002644248.1 1285810 R 561275 CDS YP_002644249.1 224989562 7562567 complement(1286861..1287544) 1 NC_012207.1 hypothetical ala-, pro-rich protein 1287544 7562567 JTY_1192 Mycobacterium bovis BCG str. Tokyo 172 hypothetical ala-, pro-rich protein YP_002644249.1 1286861 R 561275 CDS YP_002644250.1 224989563 7562568 1287674..1288969 1 NC_012207.1 involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis; mannosyltransferase 1288969 pimE 7562568 pimE Mycobacterium bovis BCG str. Tokyo 172 mannosyltransferase YP_002644250.1 1287674 D 561275 CDS YP_002644251.1 224989564 7562423 complement(1288966..1289250) 1 NC_012207.1 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction; pterin-4-alpha-carbinolamine dehydratase 1289250 phhB 7562423 phhB Mycobacterium bovis BCG str. Tokyo 172 pterin-4-alpha-carbinolamine dehydratase YP_002644251.1 1288966 R 561275 CDS YP_002644252.1 224989565 7562408 1289277..1289702 1 NC_012207.1 mutator protein 1289702 mutT2 7562408 mutT2 Mycobacterium bovis BCG str. Tokyo 172 mutator protein YP_002644252.1 1289277 D 561275 CDS YP_002644253.1 224989566 7563582 1290010..1293708 1 NC_012207.1 Differs from Rv1161 by 2aa, L458V, G821D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; respiratory nitrate reductase alpha chain 1293708 narG 7563582 narG Mycobacterium bovis BCG str. Tokyo 172 respiratory nitrate reductase alpha chain YP_002644253.1 1290010 D 561275 CDS YP_002644254.1 224989567 7563593 1293747..1295423 1 NC_012207.1 respiratory nitrate reductase subunit beta 1295423 narH 7563593 narH Mycobacterium bovis BCG str. Tokyo 172 respiratory nitrate reductase subunit beta YP_002644254.1 1293747 D 561275 CDS YP_002644255.1 224989568 7562446 1295480..1296085 1 NC_012207.1 Differs from Rv1163 and Mb1195 by 1aa, L106P in Mycobacterium bovis BCG Pasteur.; respiratory nitrate reductase delta chain 1296085 narJ 7562446 narJ Mycobacterium bovis BCG str. Tokyo 172 respiratory nitrate reductase delta chain YP_002644255.1 1295480 D 561275 CDS YP_002644256.1 224989569 7562448 1296088..1296828 1 NC_012207.1 Differs from Rv1164 by 1aa, V200A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; respiratory nitrate reductase gamma chain 1296828 narI 7562448 narI Mycobacterium bovis BCG str. Tokyo 172 respiratory nitrate reductase gamma chain YP_002644256.1 1296088 D 561275 CDS YP_002644257.1 224989570 7562447 1296850..1298736 1 NC_012207.1 Differs from Rv1165, Mb1197 by 1aa L98V in Mycobacterium bovis BCG Tokyo.; GTP-binding translation elongation factor 1298736 typA 7562447 typA Mycobacterium bovis BCG str. Tokyo 172 GTP-binding translation elongation factor YP_002644257.1 1296850 D 561275 CDS YP_002644258.1 224989571 7561645 1298834..1300741 1 NC_012207.1 lipoprotein 1300741 lpqW 7561645 lpqW Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644258.1 1298834 D 561275 CDS YP_002644259.1 224989572 7560515 complement(1300769..1301374) 1 NC_012207.1 transcriptional regulatory protein 1301374 7560515 JTY_1202 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644259.1 1300769 R 561275 CDS YP_002644260.1 224989573 7562153 complement(1301945..1302487) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PPE17 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-C) splits PPE17 into 2 parts, PPE17a and PPE17b; PPE Family protein 1302487 PPE17a 7562153 PPE17a Mycobacterium bovis BCG str. Tokyo 172 PPE Family protein YP_002644260.1 1301945 R 561275 CDS YP_002644261.1 224989574 7562152 complement(1302505..1302807) 1 NC_012207.1 PE family protein 1302807 PE11 7562152 PE11 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002644261.1 1302505 R 561275 CDS YP_002644262.1 224989575 7561711 1302987..1303898 1 NC_012207.1 N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha- D-Glucopyranoside deacetylase 1303898 mshB 7561711 mshB Mycobacterium bovis BCG str. Tokyo 172 N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha- D-Glucopyranoside deacetylase YP_002644262.1 1302987 D 561275 CDS YP_002644263.1 224989576 7563564 1303990..1304430 1 NC_012207.1 hypothetical protein 1304430 7563564 JTY_1207 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644263.1 1303990 D 561275 CDS YP_002644264.1 224989577 7562570 complement(1304438..1305364) 1 NC_012207.1 Differs from Rv1172c by 1aa, H133Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PE family protein 1305364 PE12 7562570 PE12 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002644264.1 1304438 R 561275 CDS YP_002644265.1 224989578 7561712 1305614..1308184 1 NC_012207.1 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; FO synthase 1308184 fbiC 7561712 fbiC Mycobacterium bovis BCG str. Tokyo 172 FO synthase YP_002644265.1 1305614 D 561275 CDS YP_002644266.1 224989579 7563399 complement(1308290..1308622) 1 NC_012207.1 hypothetical protein 1308622 7563399 JTY_1210 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644266.1 1308290 R 561275 CDS YP_002644267.1 224989580 7562571 complement(1308823..1310847) 1 NC_012207.1 Differs from Rv1175c by 3aa, N90T, S210T, S649I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; NADPH dependent 2,4-dienoyl-CoA reductase 1310847 fadH 7562571 fadH Mycobacterium bovis BCG str. Tokyo 172 NADPH dependent 2,4-dienoyl-CoA reductase YP_002644267.1 1308823 R 561275 CDS YP_002644268.1 224989581 7563393 complement(1310844..1311413) 1 NC_012207.1 hypothetical protein 1311413 7563393 JTY_1212 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644268.1 1310844 R 561275 CDS YP_002644269.1 224989582 7562572 1311626..1311952 1 NC_012207.1 ferredoxin 1311952 fdxC 7562572 fdxC Mycobacterium bovis BCG str. Tokyo 172 ferredoxin YP_002644269.1 1311626 D 561275 CDS YP_002644270.1 224989583 7563408 1311985..1313073 1 NC_012207.1 catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; N-succinyldiaminopimelate aminotransferase 1313073 7563408 JTY_1214 Mycobacterium bovis BCG str. Tokyo 172 N-succinyldiaminopimelate aminotransferase YP_002644270.1 1311985 D 561275 CDS YP_002644271.1 224989584 7562573 complement(1313101..1315920) 1 NC_012207.1 hypothetical protein 1315920 7562573 JTY_1215 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644271.1 1313101 R 561275 CDS YP_002644272.1 224989585 7562574 1316347..1322604 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1180 and Rv1181 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transversion (A-C) leads to a single product (similar to other organisms). Differs from Rv1181 by 2aa, A1068D, P1423A in BCG Pasteur and BCG Tokyo; polyketide beta-ketoacyl synthase 1322604 pks3 7562574 pks3 Mycobacterium bovis BCG str. Tokyo 172 polyketide beta-ketoacyl synthase YP_002644272.1 1316347 D 561275 CDS YP_002644273.1 224989586 7562120 1322657..1324075 1 NC_012207.1 polyketide synthase associated protein 1324075 papA3 7562120 papA3 Mycobacterium bovis BCG str. Tokyo 172 polyketide synthase associated protein YP_002644273.1 1322657 D 561275 CDS YP_002644274.1 224989587 7562513 1324142..1327150 1 NC_012207.1 transmembrane transport protein 1327150 mmpL10 7562513 mmpL10 Mycobacterium bovis BCG str. Tokyo 172 transmembrane transport protein YP_002644274.1 1324142 D 561275 CDS YP_002644275.1 224989588 7564480 complement(1327154..1328233) 1 NC_012207.1 hypothetical protein 1328233 7564480 JTY_1219 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644275.1 1327154 R 561275 CDS YP_002644276.1 224989589 7562575 complement(1328398..1330134) 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1330134 fadD21 7562575 fadD21 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002644276.1 1328398 R 561275 CDS YP_002644277.1 224989590 7562927 complement(1330311..1331927) 1 NC_012207.1 Differs from Rv1186c by 1aa, A207P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1331927 7562927 JTY_1221 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644277.1 1330311 R 561275 CDS YP_002644278.1 224989591 7562576 1332012..1333643 1 NC_012207.1 pyrroline-5-carboxylate dehydrogenase 1333643 rocA 7562576 rocA Mycobacterium bovis BCG str. Tokyo 172 pyrroline-5-carboxylate dehydrogenase YP_002644278.1 1332012 D 561275 CDS YP_002644279.1 224989592 7561590 1333643..1334632 1 NC_012207.1 proline dehydrogenase 1334632 7561590 JTY_1223 Mycobacterium bovis BCG str. Tokyo 172 proline dehydrogenase YP_002644279.1 1333643 D 561275 CDS YP_002644280.1 224989593 7562577 1334714..1335586 1 NC_012207.1 member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigI 1335586 sigI 7562577 sigI Mycobacterium bovis BCG str. Tokyo 172 RNA polymerase sigma factor SigI YP_002644280.1 1334714 D 561275 CDS YP_002644281.1 224989594 7561793 1335602..1336480 1 NC_012207.1 hypothetical protein 1336480 7561793 JTY_1225 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644281.1 1335602 D 561275 CDS YP_002644282.1 224989595 7562578 1336553..1337467 1 NC_012207.1 hypothetical protein 1337467 7562578 JTY_1226 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644282.1 1336553 D 561275 CDS YP_002644283.1 224989596 7562579 1337549..1338376 1 NC_012207.1 hypothetical protein 1338376 7562579 JTY_1227 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644283.1 1337549 D 561275 CDS YP_002644284.1 224989597 7562580 1338416..1339837 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1339837 7562580 JTY_1228 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002644284.1 1338416 D 561275 CDS YP_002644285.1 224989598 7562581 complement(1339870..1341135) 1 NC_012207.1 hypothetical protein 1341135 7562581 JTY_1229 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644285.1 1339870 R 561275 CDS YP_002644286.1 224989599 7562582 1341611..1341910 1 NC_012207.1 PE family protein 1341910 PE13 7562582 PE13 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002644286.1 1341611 D 561275 CDS YP_002644287.1 224989600 7561713 1341957..1343129 1 NC_012207.1 In Mycobacterium bovis, a 14 bp to 11 bp substitution leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (390 aa versus 391 aa). Differs extensively from orthologs Mb1228 and Rv1196 due to numerous substitutions and transitions. Region from aa 210 - 260 shows most difference; PPE family protein 1343129 PPE18 7561713 PPE18 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644287.1 1341957 D 561275 CDS YP_002644288.1 224989601 7562154 1343264..1343560 1 NC_012207.1 Differs from Mb1229 by 1aa, A58T in BCG Pasteur and BCG Tokyo; EsaT-6 like protein 3 1343560 esxK 7562154 esxK Mycobacterium bovis BCG str. Tokyo 172 EsaT-6 like protein 3 YP_002644288.1 1343264 D 561275 CDS YP_002644289.1 224989602 7562882 1343611..1343895 1 NC_012207.1 Differs from Rv1198 by 1aa, D12A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; EsaT-6 like protein 4 1343895 esxL 7562882 esxL Mycobacterium bovis BCG str. Tokyo 172 EsaT-6 like protein 4 YP_002644289.1 1343611 D 561275 CDS YP_002644290.1 224989603 7562883 complement(1343963..1345210) 1 NC_012207.1 Differs from Rv1199c and Mb1231c by 1aa, G90D in Mycobacterium bovis BCG Pasteur and BCG Tokyo; transposase 1345210 7562883 JTY_1234 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002644290.1 1343963 R 561275 CDS YP_002644291.1 224989604 7562583 1345547..1346824 1 NC_012207.1 integral membrane transport protein 1346824 7562583 JTY_1235 Mycobacterium bovis BCG str. Tokyo 172 integral membrane transport protein YP_002644291.1 1345547 D 561275 CDS YP_002644292.1 224989605 7562584 complement(1346821..1347774) 1 NC_012207.1 transferase 1347774 7562584 JTY_1236 Mycobacterium bovis BCG str. Tokyo 172 transferase YP_002644292.1 1346821 R 561275 CDS YP_002644293.1 224989606 7562585 1347865..1348929 1 NC_012207.1 catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; succinyl-diaminopimelate desuccinylase 1348929 dapE 7562585 dapE Mycobacterium bovis BCG str. Tokyo 172 succinyl-diaminopimelate desuccinylase YP_002644293.1 1347865 D 561275 CDS YP_002644294.1 224989607 7561468 complement(1348926..1349510) 1 NC_012207.1 hypothetical protein 1349510 7561468 JTY_1238 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644294.1 1348926 R 561275 CDS YP_002644295.1 224989608 7562586 complement(1349541..1351229) 1 NC_012207.1 hypothetical protein 1351229 7562586 JTY_1239 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644295.1 1349541 R 561275 CDS YP_002644296.1 224989609 7562587 1351324..1351887 1 NC_012207.1 hypothetical protein 1351887 7562587 JTY_1240 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644296.1 1351324 D 561275 CDS YP_002644297.1 224989610 7562588 1351937..1353730 1 NC_012207.1 activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization; long-chain-acyl-CoA synthetase 1353730 fadD6 7562588 fadD6 Mycobacterium bovis BCG str. Tokyo 172 long-chain-acyl-CoA synthetase YP_002644297.1 1351937 D 561275 CDS YP_002644298.1 224989611 7563354 1353796..1354752 1 NC_012207.1 dihydropteroate synthase 2 1354752 folP2 7563354 folP2 Mycobacterium bovis BCG str. Tokyo 172 dihydropteroate synthase 2 YP_002644298.1 1353796 D 561275 CDS YP_002644299.1 224989612 7563425 1354749..1355723 1 NC_012207.1 glucosyl-3-phosphoglycerate synthase 1355723 7563425 JTY_1243 Mycobacterium bovis BCG str. Tokyo 172 glucosyl-3-phosphoglycerate synthase YP_002644299.1 1354749 D 561275 CDS YP_002644300.1 224989613 7562589 1355762..1356130 1 NC_012207.1 hypothetical protein 1356130 7562589 JTY_1244 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644300.1 1355762 D 561275 CDS YP_002644301.1 224989614 7562590 1356127..1356741 1 NC_012207.1 DNA-3-methyladenine glycosylase I 1356741 tagA 7562590 tagA Mycobacterium bovis BCG str. Tokyo 172 DNA-3-methyladenine glycosylase I YP_002644301.1 1356127 D 561275 CDS YP_002644302.1 224989615 7561820 1356848..1357075 1 NC_012207.1 hypothetical protein 1357075 7561820 JTY_1246 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644302.1 1356848 D 561275 CDS YP_002644303.1 224989616 7562591 complement(1357103..1358266) 1 NC_012207.1 Differs from Rv1212c by 2aa, I105V, W340L and from Mb1244c by 1aa, W340L in BCG Pasteur and BCG Tokyo; glycosyl transferase 1358266 7562591 JTY_1247 Mycobacterium bovis BCG str. Tokyo 172 glycosyl transferase YP_002644303.1 1357103 R 561275 CDS YP_002644304.1 224989617 7562592 1358441..1359655 1 NC_012207.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1359655 glgC 7562592 glgC Mycobacterium bovis BCG str. Tokyo 172 glucose-1-phosphate adenylyltransferase YP_002644304.1 1358441 D 561275 CDS YP_002644305.1 224989618 7561921 complement(1359898..1360230) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, PE14 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 5 bp deletion (cttgt-*) leads to a diffferent COOH terminus; PE family protein 1360230 PE14 7561921 PE14 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002644305.1 1359898 R 561275 CDS YP_002644306.1 224989619 7561714 complement(1360364..1362049) 1 NC_012207.1 Differs from Rv1215c by 1aa, S169A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1362049 7561714 JTY_1250 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644306.1 1360364 R 561275 CDS YP_002644307.1 224989620 7562593 complement(1362077..1362751) 1 NC_012207.1 integral membrane protein 1362751 7562593 JTY_1251 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002644307.1 1362077 R 561275 CDS YP_002644308.1 224989621 7562594 complement(1362760..1364406) 1 NC_012207.1 Differs from Mb1249c by 1aa, A143T in BCG Pasteur and BCG Tokyo; tetronasin-transport integral membrane protein ABC transporter 1364406 7562594 JTY_1252 Mycobacterium bovis BCG str. Tokyo 172 tetronasin-transport integral membrane protein ABC transporter YP_002644308.1 1362760 R 561275 CDS YP_002644309.1 224989622 7562595 complement(1364403..1365338) 1 NC_012207.1 Differs from Rv1218c by 1aa, R243Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; tetronasin-transport ATP-binding protein ABC transporter 1365338 7562595 JTY_1253 Mycobacterium bovis BCG str. Tokyo 172 tetronasin-transport ATP-binding protein ABC transporter YP_002644309.1 1364403 R 561275 CDS YP_002644310.1 224989623 7562596 complement(1365328..1365966) 1 NC_012207.1 Differs from Rv1219c and Mb1251c by 1aa, C113W in BCG Pasteur and BCG Tokyo; transcriptional regulatory protein 1365966 7562596 JTY_1254 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644310.1 1365328 R 561275 CDS YP_002644311.1 224989624 7562597 complement(1366108..1366755) 1 NC_012207.1 methyltransferase 1366755 7562597 JTY_1255 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase YP_002644311.1 1366108 R 561275 CDS YP_002644312.1 224989625 7562598 1367018..1367791 1 NC_012207.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence; RNA polymerase sigma factor SigE 1367791 sigE 7562598 sigE Mycobacterium bovis BCG str. Tokyo 172 RNA polymerase sigma factor SigE YP_002644312.1 1367018 D 561275 CDS YP_002644313.1 224989626 7560793 1367949..1368413 1 NC_012207.1 hypothetical protein 1368413 7560793 JTY_1257 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644313.1 1367949 D 561275 CDS YP_002644314.1 224989627 7562599 1368482..1370068 1 NC_012207.1 Differs from Rv1223 by 2aa, L288F, N445S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; serine protease 1370068 htrA 7562599 htrA Mycobacterium bovis BCG str. Tokyo 172 serine protease YP_002644314.1 1368482 D 561275 CDS YP_002644315.1 224989628 7563333 1370070..1370465 1 NC_012207.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 1370465 tatB 7563333 tatB Mycobacterium bovis BCG str. Tokyo 172 sec-independent translocase YP_002644315.1 1370070 D 561275 CDS YP_002644316.1 224989629 7561824 complement(1370498..1371328) 1 NC_012207.1 hypothetical protein 1371328 7561824 JTY_1260 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644316.1 1370498 R 561275 CDS YP_002644317.1 224989630 7562600 complement(1371439..1372902) 1 NC_012207.1 Differs from Rv1226c by 1aa, A450V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 1372902 7562600 JTY_1261 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002644317.1 1371439 R 561275 CDS YP_002644318.1 224989631 7562601 complement(1372899..1373432) 1 NC_012207.1 transmembrane protein 1373432 7562601 JTY_1262 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002644318.1 1372899 R 561275 CDS YP_002644319.1 224989632 7562602 1373527..1374084 1 NC_012207.1 lipoprotein 1374084 lpqX 7562602 lpqX Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644319.1 1373527 D 561275 CDS YP_002644320.1 224989633 7560516 complement(1374384..1375556) 1 NC_012207.1 MRP-related protein 1375556 mrp 7560516 mrp Mycobacterium bovis BCG str. Tokyo 172 MRP-related protein YP_002644320.1 1374384 R 561275 CDS YP_002644321.1 224989634 7563560 complement(1375569..1376804) 1 NC_012207.1 Differs from Rv1230c by 2aa, G45S, P97S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1376804 7563560 JTY_1265 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644321.1 1375569 R 561275 CDS YP_002644322.1 224989635 7562603 complement(1376929..1377471) 1 NC_012207.1 hypothetical protein 1377471 7562603 JTY_1266 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644322.1 1376929 R 561275 CDS YP_002644323.1 224989636 7562604 complement(1377468..1378775) 1 NC_012207.1 Differs from Rv1232c by 1aa, G149C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1378775 7562604 JTY_1267 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644323.1 1377468 R 561275 CDS YP_002644324.1 224989637 7562605 complement(1378837..1379433) 1 NC_012207.1 Differs from Rv1233c by 1aa, D46N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1379433 7562605 JTY_1268 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644324.1 1378837 R 561275 CDS YP_002644325.1 224989638 7562606 1379583..1380110 1 NC_012207.1 transmembrane protein 1380110 7562606 JTY_1269 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002644325.1 1379583 D 561275 CDS YP_002644326.1 224989639 7562607 1380131..1381537 1 NC_012207.1 sugar-binding lipoprotein 1381537 lpqY 7562607 lpqY Mycobacterium bovis BCG str. Tokyo 172 sugar-binding lipoprotein YP_002644326.1 1380131 D 561275 CDS YP_002644327.1 224989640 7560517 1381534..1382457 1 NC_012207.1 sugar-transport integral membrane protein ABC transporter 1382457 sugA 7560517 sugA Mycobacterium bovis BCG str. Tokyo 172 sugar-transport integral membrane protein ABC transporter YP_002644327.1 1381534 D 561275 CDS YP_002644328.1 224989641 7561815 1382462..1383286 1 NC_012207.1 sugar-transport integral membrane protein ABC transporter 1383286 sugB 7561815 sugB Mycobacterium bovis BCG str. Tokyo 172 sugar-transport integral membrane protein ABC transporter YP_002644328.1 1382462 D 561275 CDS YP_002644329.1 224989642 7561816 1383291..1384472 1 NC_012207.1 sugar-transport ATP-binding protein ABC transporter 1384472 sugC 7561816 sugC Mycobacterium bovis BCG str. Tokyo 172 sugar-transport ATP-binding protein ABC transporter YP_002644329.1 1383291 D 561275 CDS YP_002644330.1 224989643 7561817 complement(1384549..1385649) 1 NC_012207.1 Differs from Rv1239c by 1aa, E139K, and from Mb1271c by 1aa, H195R in BCG Pasteur and BCG Tokyo; magnesium and cobalt transport transmembrane protein 1385649 corA 7561817 corA Mycobacterium bovis BCG str. Tokyo 172 magnesium and cobalt transport transmembrane protein YP_002644330.1 1384549 R 561275 CDS YP_002644331.1 224989644 7563120 1385820..1386809 1 NC_012207.1 catalyzes the oxidation of malate to oxaloacetate; malate dehydrogenase 1386809 mdh 7563120 mdh Mycobacterium bovis BCG str. Tokyo 172 malate dehydrogenase YP_002644331.1 1385820 D 561275 CDS YP_002644332.1 224989645 7564448 1386885..1387145 1 NC_012207.1 hypothetical protein 1387145 7564448 JTY_1276 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644332.1 1386885 D 561275 CDS YP_002644333.1 224989646 7562608 1387142..1387573 1 NC_012207.1 hypothetical protein 1387573 7562608 JTY_1277 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644333.1 1387142 D 561275 CDS YP_002644334.1 224989647 7562609 complement(1387596..1389284) 1 NC_012207.1 PE-PGRS family protein 1389284 PE_PGRS23 7562609 PE_PGRS23 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644334.1 1387596 R 561275 CDS YP_002644335.1 224989648 7561764 1389464..1390324 1 NC_012207.1 Differs from Rv1244 by 1aa, K242Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 1390324 lpqZ 7561764 lpqZ Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644335.1 1389464 D 561275 CDS YP_002644336.1 224989649 7560518 complement(1390405..1391235) 1 NC_012207.1 short-chain type dehydrogenase/reductase 1391235 7560518 JTY_1280 Mycobacterium bovis BCG str. Tokyo 172 short-chain type dehydrogenase/reductase YP_002644336.1 1390405 R 561275 CDS YP_002644337.1 224989650 7563594 complement(1391292..1391585) 1 NC_012207.1 hypothetical protein 1391585 7563594 JTY_1281 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644337.1 1391292 R 561275 CDS YP_002644338.1 224989651 7563595 complement(1391582..1391851) 1 NC_012207.1 hypothetical protein 1391851 7563595 JTY_1282 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644338.1 1391582 R 561275 CDS YP_002644339.1 224989652 7563596 complement(1391964..1395608) 1 NC_012207.1 kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; alpha-ketoglutarate decarboxylase 1395608 kgd 7563596 kgd Mycobacterium bovis BCG str. Tokyo 172 alpha-ketoglutarate decarboxylase YP_002644339.1 1391964 R 561275 CDS YP_002644340.1 224989653 7562807 complement(1395801..1396589) 1 NC_012207.1 Differs from Rv1249c by 1aa, T95A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1396589 7562807 JTY_1284 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644340.1 1395801 R 561275 CDS YP_002644341.1 224989654 7563597 1396786..1398525 1 NC_012207.1 Differs from Rv1250 by 1aa, G278R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; drug-transport integral membrane protein 1398525 7563597 JTY_1285 Mycobacterium bovis BCG str. Tokyo 172 drug-transport integral membrane protein YP_002644341.1 1396786 D 561275 CDS YP_002644342.1 224989655 7563598 complement(1398428..1401847) 1 NC_012207.1 hypothetical protein 1401847 7563598 JTY_1286 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644342.1 1398428 R 561275 CDS YP_002644343.1 224989656 7563599 complement(1401903..1402511) 1 NC_012207.1 lipoprotein 1402511 lprE 7563599 lprE Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644343.1 1401903 R 561275 CDS YP_002644344.1 224989657 7560523 1402577..1404268 1 NC_012207.1 Differs from Rv1253 by 1aa, V143M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cold-shock dead-box protein a homolog 1404268 deaD 7560523 deaD Mycobacterium bovis BCG str. Tokyo 172 cold-shock dead-box protein a homolog YP_002644344.1 1402577 D 561275 CDS YP_002644345.1 224989658 7561473 1404265..1405416 1 NC_012207.1 acyltransferase 1405416 7561473 JTY_1289 Mycobacterium bovis BCG str. Tokyo 172 acyltransferase YP_002644345.1 1404265 D 561275 CDS YP_002644346.1 224989659 7563600 complement(1405385..1405684) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 3007 bp deletion (RD13) leads to the fusion of Rv1257c and Rv1255c, and the deletion of Rv1256c, compared to Mycobacterium tuberculosis strain H37Rv; hypothetical protein 1405684 7563600 JTY_1290 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644346.1 1405385 R 561275 CDS YP_002644347.1 224989660 7563601 complement(1405681..1406940) 1 NC_012207.1 integral membrane transport protein 1406940 7563601 JTY_1291 Mycobacterium bovis BCG str. Tokyo 172 integral membrane transport protein YP_002644347.1 1405681 R 561275 CDS YP_002644348.1 224989661 7563602 1406939..1407838 1 NC_012207.1 hypothetical protein 1407838 7563602 JTY_1292 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644348.1 1406939 D 561275 CDS YP_002644349.1 224989662 7563603 1407840..1408664 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv1260 into 2 parts; oxidoreductase 1408664 7563603 JTY_1293 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002644349.1 1407840 D 561275 CDS YP_002644350.1 224989663 7563604 1408649..1408957 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv1260 into 2 parts; oxidoreductase 1408957 7563604 JTY_1294 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002644350.1 1408649 D 561275 CDS YP_002644351.1 224989664 7563605 complement(1409083..1409532) 1 NC_012207.1 hypothetical protein 1409532 7563605 JTY_1295 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644351.1 1409083 R 561275 CDS YP_002644352.1 224989665 7563606 complement(1409537..1409971) 1 NC_012207.1 Differs from Rv1262c by 1aa, R104P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical HIT-like protein 1409971 7563606 JTY_1296 Mycobacterium bovis BCG str. Tokyo 172 hypothetical HIT-like protein YP_002644352.1 1409537 R 561275 CDS YP_002644353.1 224989666 7563607 1410030..1411418 1 NC_012207.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 1411418 amiB2 7563607 amiB2 Mycobacterium bovis BCG str. Tokyo 172 amidase YP_002644353.1 1410030 D 561275 CDS YP_002644354.1 224989667 7563972 1411493..1412686 1 NC_012207.1 Differs from Rv1264 by 1aa, C204R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; adenylyl cyclase 1412686 7563972 JTY_1298 Mycobacterium bovis BCG str. Tokyo 172 adenylyl cyclase YP_002644354.1 1411493 D 561275 CDS YP_002644355.1 224989668 7563608 1412859..1413539 1 NC_012207.1 hypothetical protein 1413539 7563608 JTY_1299 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644355.1 1412859 D 561275 CDS YP_002644356.1 224989669 7563609 complement(1413559..1415349) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, the pknH gene contains several substitutions, transitions and transversions compared to Mycobacterium tuberculosis strain H37Rv. The most significant difference results from a 127 bp to 24 bp substitution that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (596 aa versus 626 aa). Differs from Mb1297c by 2aa, F374L, I396N in BCG Pasteur and BCG Tokyo; transmembrane serine/threonine-protein kinase H 1415349 pknH 7563609 pknH Mycobacterium bovis BCG str. Tokyo 172 transmembrane serine/threonine-protein kinase H YP_002644356.1 1413559 R 561275 CDS YP_002644357.1 224989670 7562435 complement(1415690..1416856) 1 NC_012207.1 transcriptional regulatory protein 1416856 embR 7562435 embR Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644357.1 1415690 R 561275 CDS YP_002644358.1 224989671 7562860 complement(1417167..1417865) 1 NC_012207.1 hypothetical protein 1417865 7562860 JTY_1302 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644358.1 1417167 R 561275 CDS YP_002644359.1 224989672 7563610 complement(1418088..1418462) 1 NC_012207.1 hypothetical protein 1418462 7563610 JTY_1303 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644359.1 1418088 R 561275 CDS YP_002644360.1 224989673 7563611 complement(1418523..1419257) 1 NC_012207.1 Differs from Mb1301c by 1aa, A134T in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 1419257 lprA 7563611 lprA Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644360.1 1418523 R 561275 CDS YP_002644361.1 224989674 7560519 complement(1419470..1419811) 1 NC_012207.1 hypothetical protein 1419811 7560519 JTY_1305 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644361.1 1419470 R 561275 CDS YP_002644362.1 224989675 7563612 complement(1419919..1421814) 1 NC_012207.1 drugs-transport transmembrane ATP-binding protein ABC transporter 1421814 7563612 JTY_1306 Mycobacterium bovis BCG str. Tokyo 172 drugs-transport transmembrane ATP-binding protein ABC transporter YP_002644362.1 1419919 R 561275 CDS YP_002644363.1 224989676 7563613 complement(1421811..1423559) 1 NC_012207.1 drugs-transport transmembrane ATP-binding protein ABC transporter 1423559 7563613 JTY_1307 Mycobacterium bovis BCG str. Tokyo 172 drugs-transport transmembrane ATP-binding protein ABC transporter YP_002644363.1 1421811 R 561275 CDS YP_002644364.1 224989677 7563614 1423706..1424263 1 NC_012207.1 Differs from Rv1274 by 1aa, P168L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 1424263 lprB 7563614 lprB Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644364.1 1423706 D 561275 CDS YP_002644365.1 224989678 7560520 1424260..1424802 1 NC_012207.1 lipoprotein 1424802 lprC 7560520 lprC Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644365.1 1424260 D 561275 CDS YP_002644366.1 224989679 7560521 complement(1424947..1425423) 1 NC_012207.1 Differs from Rv1276c by 1aa, S92T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1425423 7560521 JTY_1310 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644366.1 1424947 R 561275 CDS YP_002644367.1 224989680 7563615 1425673..1426926 1 NC_012207.1 hypothetical protein 1426926 7563615 JTY_1311 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644367.1 1425673 D 561275 CDS YP_002644368.1 224989681 7563616 1426923..1429550 1 NC_012207.1 hypothetical protein 1429550 7563616 JTY_1312 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644368.1 1426923 D 561275 CDS YP_002644369.1 224989682 7563617 1429571..1431157 1 NC_012207.1 dehydrogenase FAD flavoprotein gmc oxidoreductase 1431157 7563617 JTY_1313 Mycobacterium bovis BCG str. Tokyo 172 dehydrogenase FAD flavoprotein gmc oxidoreductase YP_002644369.1 1429571 D 561275 CDS YP_002644370.1 224989683 7563618 complement(1431174..1432949) 1 NC_012207.1 periplasmic oligopeptide-binding lipoprotein 1432949 oppA 7563618 oppA Mycobacterium bovis BCG str. Tokyo 172 periplasmic oligopeptide-binding lipoprotein YP_002644370.1 1431174 R 561275 CDS YP_002644371.1 224989684 7562497 complement(1432942..1434780) 1 NC_012207.1 oligopeptide-transport ATP-binding protein ABC transporter 1434780 oppD 7562497 oppD Mycobacterium bovis BCG str. Tokyo 172 oligopeptide-transport ATP-binding protein ABC transporter YP_002644371.1 1432942 R 561275 CDS YP_002644372.1 224989685 7562500 complement(1434777..1435652) 1 NC_012207.1 oligopeptide-transport integral membrane protein ABC transporter 1435652 oppC 7562500 oppC Mycobacterium bovis BCG str. Tokyo 172 oligopeptide-transport integral membrane protein ABC transporter YP_002644372.1 1434777 R 561275 CDS YP_002644373.1 224989686 7562499 complement(1435649..1436626) 1 NC_012207.1 oligopeptide-transport integral membrane protein ABC transporter 1436626 oppB 7562499 oppB Mycobacterium bovis BCG str. Tokyo 172 oligopeptide-transport integral membrane protein ABC transporter YP_002644373.1 1435649 R 561275 CDS YP_002644374.1 224989687 7562498 1436833..1437324 1 NC_012207.1 beta-carbonic anhydrase 1437324 canA 7562498 canA Mycobacterium bovis BCG str. Tokyo 172 beta-carbonic anhydrase YP_002644374.1 1436833 D 561275 CDS YP_002644375.1 224989688 7562080 1437418..1438416 1 NC_012207.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 1438416 cysD 7562080 cysD Mycobacterium bovis BCG str. Tokyo 172 sulfate adenylyltransferase subunit 2 YP_002644375.1 1437418 D 561275 CDS YP_002644376.1 224989689 7563175 1438416..1440260 1 NC_012207.1 in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis; bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein 1440260 cysN 7563175 cysN Mycobacterium bovis BCG str. Tokyo 172 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein YP_002644376.1 1438416 D 561275 CDS YP_002644377.1 224989690 7563181 1440314..1440799 1 NC_012207.1 hypothetical protein 1440799 7563181 JTY_1321 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644377.1 1440314 D 561275 CDS YP_002644378.1 224989691 7563619 1440857..1442074 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 153 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (405 aa versus 456 aa); hypothetical protein 1442074 7563619 JTY_1322 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644378.1 1440857 D 561275 CDS YP_002644379.1 224989692 7563620 1442123..1442755 1 NC_012207.1 hypothetical protein 1442755 7563620 JTY_1323 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644379.1 1442123 D 561275 CDS YP_002644380.1 224989693 7563621 complement(1442894..1444459) 1 NC_012207.1 hypothetical protein 1444459 7563621 JTY_1324 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644380.1 1442894 R 561275 CDS YP_002644381.1 224989694 7563622 1444470..1444784 1 NC_012207.1 hypothetical protein 1444784 7563622 JTY_1325 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644381.1 1444470 D 561275 CDS YP_002644382.1 224989695 7563623 complement(1444911..1445246) 1 NC_012207.1 hypothetical protein 1445246 7563623 JTY_1326 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644382.1 1444911 R 561275 CDS YP_002644383.1 224989696 7563994 1445791..1447443 1 NC_012207.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1447443 argS 7563994 argS Mycobacterium bovis BCG str. Tokyo 172 arginyl-tRNA synthetase YP_002644383.1 1445791 D 561275 CDS YP_002644384.1 224989697 7563991 1447440..1448783 1 NC_012207.1 diaminopimelate decarboxylase 1448783 lysA 7563991 lysA Mycobacterium bovis BCG str. Tokyo 172 diaminopimelate decarboxylase YP_002644384.1 1447440 D 561275 CDS YP_002644385.1 224989698 7560540 1448787..1450112 1 NC_012207.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1450112 thrA 7560540 thrA Mycobacterium bovis BCG str. Tokyo 172 homoserine dehydrogenase YP_002644385.1 1448787 D 561275 CDS YP_002644386.1 224989699 7561850 1450109..1451191 1 NC_012207.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1451191 thrC 7561850 thrC Mycobacterium bovis BCG str. Tokyo 172 threonine synthase YP_002644386.1 1450109 D 561275 CDS YP_002644387.1 224989700 7561852 1451409..1452359 1 NC_012207.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1452359 thrB 7561852 thrB Mycobacterium bovis BCG str. Tokyo 172 homoserine kinase YP_002644387.1 1451409 D 561275 CDS YP_002644388.1 224989701 7561851 1452616..1454424 1 NC_012207.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 1454424 rho 7561851 rho Mycobacterium bovis BCG str. Tokyo 172 transcription termination factor Rho YP_002644388.1 1452616 D 561275 CDS YP_002644389.1 224989702 7561570 1454575..1454817 1 NC_012207.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1454817 rpmE 7561570 rpmE Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L31 YP_002644389.1 1454575 D 561275 CDS YP_002644390.1 224989703 7560718 1454907..1455980 1 NC_012207.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1455980 prfA 7560718 prfA Mycobacterium bovis BCG str. Tokyo 172 peptide chain release factor 1 YP_002644390.1 1454907 D 561275 CDS YP_002644391.1 224989704 7560821 1455977..1456954 1 NC_012207.1 Differs from Mb1332 by 1aa, G121A, and from Rv1300by 2aa, G121A, C194R in Mycobacterium bovis BCG Pasteur and BCG Tokyo; HemK protein homolog 1456954 hemK 7560821 hemK Mycobacterium bovis BCG str. Tokyo 172 HemK protein homolog YP_002644391.1 1455977 D 561275 CDS YP_002644392.1 224989705 7563302 1456970..1457623 1 NC_012207.1 Differs from Rv1301 by 1aa, Q196P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein 1457623 7563302 JTY_1336 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644392.1 1456970 D 561275 CDS YP_002644393.1 224989706 7563625 1457707..1458921 1 NC_012207.1 Differs from Rv1302 by 1aa, G357V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase 1458921 rfe 7563625 rfe Mycobacterium bovis BCG str. Tokyo 172 undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase YP_002644393.1 1457707 D 561275 CDS YP_002644394.1 224989707 7561568 1459178..1459663 1 NC_012207.1 hypothetical protein 1459663 7561568 JTY_1338 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644394.1 1459178 D 561275 CDS YP_002644395.1 224989708 7563626 1459656..1460408 1 NC_012207.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 1460408 atpB 7563626 atpB Mycobacterium bovis BCG str. Tokyo 172 ATP synthase F0F1 subunit A YP_002644395.1 1459656 D 561275 CDS YP_002644396.1 224989709 7562048 1460457..1460702 1 NC_012207.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 1460702 atpE 7562048 atpE Mycobacterium bovis BCG str. Tokyo 172 ATP synthase F0F1 subunit C YP_002644396.1 1460457 D 561275 CDS YP_002644397.1 224989710 7562051 1460733..1461248 1 NC_012207.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 1461248 atpF 7562051 atpF Mycobacterium bovis BCG str. Tokyo 172 ATP synthase F0F1 subunit B YP_002644397.1 1460733 D 561275 CDS YP_002644398.1 224989711 7562052 1461255..1462595 1 NC_012207.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 1462595 atpH 7562052 atpH Mycobacterium bovis BCG str. Tokyo 172 ATP synthase F0F1 subunit delta YP_002644398.1 1461255 D 561275 CDS YP_002644399.1 224989712 7562054 1462640..1464289 1 NC_012207.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 1464289 atpA 7562054 atpA Mycobacterium bovis BCG str. Tokyo 172 ATP synthase F0F1 subunit alpha YP_002644399.1 1462640 D 561275 CDS YP_002644400.1 224989713 7562047 1464296..1465213 1 NC_012207.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 1465213 atpG 7562047 atpG Mycobacterium bovis BCG str. Tokyo 172 ATP synthase F0F1 subunit gamma YP_002644400.1 1464296 D 561275 CDS YP_002644401.1 224989714 7562053 1465253..1466713 1 NC_012207.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 1466713 atpD 7562053 atpD Mycobacterium bovis BCG str. Tokyo 172 ATP synthase F0F1 subunit beta YP_002644401.1 1465253 D 561275 CDS YP_002644402.1 224989715 7562050 1466727..1467092 1 NC_012207.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 1467092 atpC 7562050 atpC Mycobacterium bovis BCG str. Tokyo 172 ATP synthase F0F1 subunit epsilon YP_002644402.1 1466727 D 561275 CDS YP_002644403.1 224989716 7562049 1467100..1467534 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 2 bp deletion (CG-*) at the 3' end leads to a slightly shorter product compared to Mycobacterium tuberculosis strain H37Rv (144 aa versus 147 aa). Also differs from Rv1312 by 1aa, V3A in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 1467534 7562049 JTY_1347 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644403.1 1467100 D 561275 CDS YP_002644404.1 224989717 7563627 complement(1467581..1468915) 1 NC_012207.1 Equivalent to Rv1313c (IS1557) in BCG Tokyo. Equivalent to Mb1345c and Mb1346c in BCG Pasteur (BCG_1373c and BCG_1374c). In Mycobacterium tuberculosis strain H37Rv, Rv1313c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a 12 bp to 1bp substitution (CTTGTCGTGGCC-T) splits Rv1313c into 2 parts; transposase 1468915 7563627 JTY_1348 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002644404.1 1467581 R 561275 CDS YP_002644405.1 224989718 7563628 complement(1469081..1469662) 1 NC_012207.1 hypothetical protein 1469662 7563628 JTY_1349 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644405.1 1469081 R 561275 CDS YP_002644406.1 224989719 7563629 1469731..1470987 1 NC_012207.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1470987 murA 7563629 murA Mycobacterium bovis BCG str. Tokyo 172 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_002644406.1 1469731 D 561275 CDS YP_002644407.1 224989720 7564326 complement(1476544..1477041) 1 NC_012207.1 methylated-DNA--protein-cysteine methyltransferase 1477041 ogt 7564326 ogt Mycobacterium bovis BCG str. Tokyo 172 methylated-DNA--protein-cysteine methyltransferase YP_002644407.1 1476544 R 561275 CDS YP_002644408.1 224989721 7562492 complement(1477038..1478528) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, alkA exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a premature stop codon that splits alkA into 2 parts, alkAa and alkAb; ada regulatory protein 1478528 alkA 7562492 alkA Mycobacterium bovis BCG str. Tokyo 172 ada regulatory protein YP_002644408.1 1477038 R 561275 CDS YP_002644409.1 224989722 7563962 complement(1478609..1480234) 1 NC_012207.1 adenylate cyclase 1480234 7563962 JTY_1353 Mycobacterium bovis BCG str. Tokyo 172 adenylate cyclase YP_002644409.1 1478609 R 561275 CDS YP_002644410.1 224989723 7563630 complement(1480304..1481911) 1 NC_012207.1 adenylate cyclase 1481911 7563630 JTY_1354 Mycobacterium bovis BCG str. Tokyo 172 adenylate cyclase YP_002644410.1 1480304 R 561275 CDS YP_002644411.1 224989724 7563631 complement(1481924..1483627) 1 NC_012207.1 Differs from Rv1320c by 1aa, A531T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; adenylate cyclase 1483627 7563631 JTY_1355 Mycobacterium bovis BCG str. Tokyo 172 adenylate cyclase YP_002644411.1 1481924 R 561275 CDS YP_002644412.1 224989725 7563632 1483689..1484369 1 NC_012207.1 Differs from Rv1321 by 1aa, R144S in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1484369 7563632 JTY_1356 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644412.1 1483689 D 561275 CDS YP_002644413.1 224989726 7563633 1484392..1484688 1 NC_012207.1 hypothetical protein 1484688 7563633 JTY_1357 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644413.1 1484392 D 561275 CDS YP_002644414.1 224989727 7563634 complement(1484723..1485181) 1 NC_012207.1 hypothetical protein 1485181 7563634 JTY_1358 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644414.1 1484723 R 561275 CDS YP_002644415.1 224989728 7563635 1485272..1486441 1 NC_012207.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 1486441 fadA4 7563635 fadA4 Mycobacterium bovis BCG str. Tokyo 172 acetyl-CoA acetyltransferase YP_002644415.1 1485272 D 561275 CDS YP_002644416.1 224989729 7562907 1486571..1487485 1 NC_012207.1 thioredoxin 1487485 7562907 JTY_1360 Mycobacterium bovis BCG str. Tokyo 172 thioredoxin YP_002644416.1 1486571 D 561275 CDS YP_002644417.1 224989730 7563636 complement(1487564..1489366) 1 NC_012207.1 Differs from Rv1325c by 3aa:AGG, there are deleted in Mycobacterium bovis BCG Tokyo.; PE-PGRS family protein 1489366 PE_PGRS24 7563636 PE_PGRS24 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644417.1 1487564 R 561275 CDS YP_002644418.1 224989731 7561765 complement(1489518..1491713) 1 NC_012207.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 1491713 glgB 7561765 glgB Mycobacterium bovis BCG str. Tokyo 172 glycogen branching enzyme YP_002644418.1 1489518 R 561275 CDS YP_002644419.1 224989732 7561920 complement(1491721..1493826) 1 NC_012207.1 glucanase 1493826 glgE 7561920 glgE Mycobacterium bovis BCG str. Tokyo 172 glucanase YP_002644419.1 1491721 R 561275 CDS YP_002644420.1 224989733 7561922 1493965..1496556 1 NC_012207.1 Differs from Rv1328 by 3aa, G532D, F576V, S801A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; glycogen phosphorylase 1496556 glgP 7561922 glgP Mycobacterium bovis BCG str. Tokyo 172 glycogen phosphorylase YP_002644420.1 1493965 D 561275 CDS YP_002644421.1 224989734 7561923 complement(1496596..1498590) 1 NC_012207.1 ATP-dependent helicase DinG homolog 1498590 dinG 7561923 dinG Mycobacterium bovis BCG str. Tokyo 172 ATP-dependent helicase DinG homolog YP_002644421.1 1496596 R 561275 CDS YP_002644422.1 224989735 7561494 complement(1498614..1499960) 1 NC_012207.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1499960 7561494 JTY_1366 Mycobacterium bovis BCG str. Tokyo 172 nicotinate phosphoribosyltransferase YP_002644422.1 1498614 R 561275 CDS YP_002644423.1 224989736 7563637 1500062..1500367 1 NC_012207.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 1500367 clpS 7563637 clpS Mycobacterium bovis BCG str. Tokyo 172 ATP-dependent Clp protease adaptor protein ClpS YP_002644423.1 1500062 D 561275 CDS YP_002644424.1 224989737 7562111 1500327..1500983 1 NC_012207.1 transcriptional regulatory protein 1500983 7562111 JTY_1368 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644424.1 1500327 D 561275 CDS YP_002644425.1 224989738 7563638 1501000..1502034 1 NC_012207.1 hydrolase 1502034 7563638 JTY_1369 Mycobacterium bovis BCG str. Tokyo 172 hydrolase YP_002644425.1 1501000 D 561275 CDS YP_002644426.1 224989739 7563639 1502042..1502482 1 NC_012207.1 hypothetical protein 1502482 7563639 JTY_1370 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644426.1 1502042 D 561275 CDS YP_002644427.1 224989740 7563640 1502504..1502785 1 NC_012207.1 hypothetical protein 1502785 7563640 JTY_1371 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644427.1 1502504 D 561275 CDS YP_002644428.1 224989741 7563641 1502795..1503766 1 NC_012207.1 cysteine synthase B 1503766 cysM 7563641 cysM Mycobacterium bovis BCG str. Tokyo 172 cysteine synthase B YP_002644428.1 1502795 D 561275 CDS YP_002644429.1 224989742 7563180 1503757..1504479 1 NC_012207.1 integral membrane protein 1504479 7563180 JTY_1373 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002644429.1 1503757 D 561275 CDS YP_002644430.1 224989743 7563642 1504476..1505291 1 NC_012207.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1505291 murI 7563642 murI Mycobacterium bovis BCG str. Tokyo 172 glutamate racemase YP_002644430.1 1504476 D 561275 CDS YP_002644431.1 224989744 7563578 1505318..1506139 1 NC_012207.1 hypothetical protein 1506139 7563578 JTY_1375 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644431.1 1505318 D 561275 CDS YP_002644432.1 224989745 7563643 1506156..1506935 1 NC_012207.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 1506935 rph 7563643 rph Mycobacterium bovis BCG str. Tokyo 172 ribonuclease PH YP_002644432.1 1506156 D 561275 CDS YP_002644433.1 224989746 7561601 1506974..1507588 1 NC_012207.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 1507588 7561601 JTY_1377 Mycobacterium bovis BCG str. Tokyo 172 deoxyribonucleotide triphosphate pyrophosphatase YP_002644433.1 1506974 D 561275 CDS YP_002644434.1 224989747 7563644 complement(1507585..1507947) 1 NC_012207.1 hypothetical protein 1507947 7563644 JTY_1378 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644434.1 1507585 R 561275 CDS YP_002644435.1 224989748 7563645 complement(1507944..1508324) 1 NC_012207.1 Differs from Rv1343c by 1aa, A81E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 1508324 lprD 7563645 lprD Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644435.1 1507944 R 561275 CDS YP_002644436.1 224989749 7560522 1508369..1508689 1 NC_012207.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1508689 7560522 JTY_1380 Mycobacterium bovis BCG str. Tokyo 172 acyl carrier protein YP_002644436.1 1508369 D 561275 CDS YP_002644437.1 224989750 7563646 1508682..1510247 1 NC_012207.1 converts medium- to long-chain aliphatic fatty acids into acyl adenylate; involved in mycobactin synthesis; long-chain fatty acid--ACP ligase 1510247 fadD33 7563646 fadD33 Mycobacterium bovis BCG str. Tokyo 172 long-chain fatty acid--ACP ligase YP_002644437.1 1508682 D 561275 CDS YP_002644438.1 224989751 7563349 1510247..1511407 1 NC_012207.1 acyl-CoA dehydrogenase 1511407 fadE14 7563349 fadE14 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002644438.1 1510247 D 561275 CDS YP_002644439.1 224989752 7563362 complement(1511374..1512006) 1 NC_012207.1 hypothetical protein 1512006 7563362 JTY_1383 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644439.1 1511374 R 561275 CDS YP_002644440.1 224989753 7562821 1512448..1515027 1 NC_012207.1 drugs-transport transmembrane ATP-binding protein ABC transporter 1515027 7562821 JTY_1384 Mycobacterium bovis BCG str. Tokyo 172 drugs-transport transmembrane ATP-binding protein ABC transporter YP_002644440.1 1512448 D 561275 CDS YP_002644441.1 224989754 7563648 1515024..1516763 1 NC_012207.1 drugs-transport transmembrane ATP-binding protein ABC transporter 1516763 7563648 JTY_1385 Mycobacterium bovis BCG str. Tokyo 172 drugs-transport transmembrane ATP-binding protein ABC transporter YP_002644441.1 1515024 D 561275 CDS YP_002644442.1 224989755 7563649 1516892..1517635 1 NC_012207.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1517635 fabG 7563649 fabG Mycobacterium bovis BCG str. Tokyo 172 3-ketoacyl-ACP reductase YP_002644442.1 1516892 D 561275 CDS YP_002644443.1 224989756 7562897 1517632..1517961 1 NC_012207.1 hypothetical protein 1517961 7562897 JTY_1387 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644443.1 1517632 D 561275 CDS YP_002644444.1 224989757 7563650 1518164..1518535 1 NC_012207.1 hypothetical protein 1518535 7563650 JTY_1388 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644444.1 1518164 D 561275 CDS YP_002644445.1 224989758 7563651 complement(1518601..1519386) 1 NC_012207.1 transcriptional regulatory protein 1519386 7563651 JTY_1389 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644445.1 1518601 R 561275 CDS YP_002644446.1 224989759 7563652 complement(1519406..1521277) 1 NC_012207.1 hypothetical protein 1521277 7563652 JTY_1390 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644446.1 1519406 R 561275 CDS YP_002644447.1 224989760 7563653 complement(1521286..1523433) 1 NC_012207.1 Differs from Rv1355c by 1aa (P81L) in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1523433 moeY 7563653 moeY Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644447.1 1521286 R 561275 CDS YP_002644448.1 224989761 7563545 complement(1523430..1524221) 1 NC_012207.1 hypothetical protein 1524221 7563545 JTY_1392 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644448.1 1523430 R 561275 CDS YP_002644449.1 224989762 7563654 complement(1524694..1525617) 1 NC_012207.1 Differs from Rv1357c and Mb1392c by 1aa, S276T in BCG Pasteur and BCG Tokyo; hypothetical protein 1525617 7563654 JTY_1393 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644449.1 1524694 R 561275 CDS YP_002644450.1 224989763 7563655 1526013..1529492 1 NC_012207.1 Differs from Rv1358 by 1aa A442D, and from Mb1393 by 1aa, G31V in BCG Pasteur and BCG Tokyo; transcriptional regulatory protein 1529492 7563655 JTY_1394 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644450.1 1526013 D 561275 CDS YP_002644451.1 224989764 7563656 1529574..1530326 1 NC_012207.1 Differs from Mb1394 by 1aa, G187R in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional regulatory protein 1530326 7563656 JTY_1395 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644451.1 1529574 D 561275 CDS YP_002644452.1 224989765 7563657 1530749..1531771 1 NC_012207.1 oxidoreductase 1531771 7563657 JTY_1396 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002644452.1 1530749 D 561275 CDS YP_002644453.1 224989766 7563658 complement(1531844..1533034) 1 NC_012207.1 Differs from Rv1361c by 3aa, Q30K, V55T, P325Q in BCG Pasteur and BCG Tokyo, and more extensively from Mb1396c due to several substitutions, transitions and transversions between codons 158-260; PPE family protein 1533034 PPE19 7563658 PPE19 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644453.1 1531844 R 561275 CDS YP_002644454.1 224989767 7562155 complement(1533349..1534011) 1 NC_012207.1 Differs from Rv1362c by 1aa, G103V Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1534011 7562155 JTY_1398 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644454.1 1533349 R 561275 CDS YP_002644455.1 224989768 7563659 complement(1534008..1534793) 1 NC_012207.1 Difefrs from Mb1398c by 1aa, T155N in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1534793 7563659 JTY_1399 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644455.1 1534008 R 561275 CDS YP_002644456.1 224989769 7563660 complement(1535084..1537045) 1 NC_012207.1 Differs from Rv1364c by 2aa, T236A, E465A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1537045 7563660 JTY_1400 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644456.1 1535084 R 561275 CDS YP_002644457.1 224989770 7563661 complement(1537184..1537570) 1 NC_012207.1 Differs from Rv1365c by 1aa, K82E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1537570 7563661 JTY_1401 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644457.1 1537184 R 561275 CDS YP_002644458.1 224989771 7563662 1537791..1538612 1 NC_012207.1 hypothetical protein 1538612 7563662 JTY_1402 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644458.1 1537791 D 561275 CDS YP_002644459.1 224989772 7563663 complement(1538913..1540046) 1 NC_012207.1 Differs from Rv1367c by 1aa, V169I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1540046 7563663 JTY_1403 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644459.1 1538913 R 561275 CDS YP_002644460.1 224989773 7563664 1540421..1541206 1 NC_012207.1 lipoprotein 1541206 lprF 7563664 lprF Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644460.1 1540421 D 561275 CDS YP_002644461.1 224989774 7560524 1541402..1542355 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-A) splits Rv1371 into 2 parts, with the latter being the more likely product; hypothetical protein 1542355 7560524 JTY_1405 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644461.1 1541402 D 561275 CDS YP_002644462.1 224989775 7563665 1541877..1542872 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-A) splits Rv1371 into 2 parts, with the latter being the more likely product. Differs from both Mb1405 and Rv1371 by 1aa, V210I in Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 1542872 7563665 JTY_1406 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644462.1 1541877 D 561275 CDS YP_002644463.1 224989776 7563666 1542869..1544050 1 NC_012207.1 Differs from Rv1372 and Mb1406 by 2aa, N75K, A101T in Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 1544050 7563666 JTY_1407 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644463.1 1542869 D 561275 CDS YP_002644464.1 224989777 7563667 1544056..1544604 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1373 exists as a single gene as is the case in Mycobacterium bovis BCG Pasteur. In Mycobacterium bovis, a frameshift due to a single base insertion (*-C) splits Rv1373 into 2 parts, Mb1407 and Mb1408. Differs from Rv1373 by 2aa, additional P, P155, and L232P in BCG Pasteur. In Mycobacterium bovis BCG Tokyo, a frameshift due to two base insertions (*-cc) splits Rv1373 into 2 parts (182 aa, 155 aa). 9Cs in BCG Tokyo, 10Cs in BCG Pasteur.; glycolipid sulfotransferase 1544604 7563667 JTY_1408 Mycobacterium bovis BCG str. Tokyo 172 glycolipid sulfotransferase YP_002644464.1 1544056 D 561275 CDS YP_002644465.1 224989778 7563668 1544571..1545038 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1373 exists as a single gene as is the case in Mycobacterium bovis BCG Pasteur. In Mycobacterium bovis, a frameshift due to a single base insertion (*-) splits Rv1373 into 2 parts, Mb1407 and Mb1408. Differs from Rv1373 by 2aa, additional P, P155, and L232P in BCG Pasteur. In Mycobacterium bovis BCG Tokyo, a frameshift due to two base insertions (*-CC) splits Rv1373 into 2 parts (182 aa, 155 aa).; glycolipid sulfotransferase 1545038 7563668 JTY_1409 Mycobacterium bovis BCG str. Tokyo 172 glycolipid sulfotransferase YP_002644465.1 1544571 D 561275 CDS YP_002644466.1 224989779 7563669 complement(1545118..1545576) 1 NC_012207.1 Differs from Rv1374c by 1aa, A136T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1545576 7563669 JTY_1410 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644466.1 1545118 R 561275 CDS YP_002644467.1 224989780 7563670 1545878..1547197 1 NC_012207.1 Differs from Rv1375 by 1aa, R86G, and from Mb1410by 1aa, R322P in Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 1547197 7563670 JTY_1411 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644467.1 1545878 D 561275 CDS YP_002644468.1 224989781 7563671 1547194..1548687 1 NC_012207.1 Differs from Rv1376 by 1aa, P236R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1548687 7563671 JTY_1412 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644468.1 1547194 D 561275 CDS YP_002644469.1 224989782 7563672 complement(1548625..1549263) 1 NC_012207.1 transferase 1549263 7563672 JTY_1413 Mycobacterium bovis BCG str. Tokyo 172 transferase YP_002644469.1 1548625 R 561275 CDS YP_002644470.1 224989783 7563673 complement(1549274..1550701) 1 NC_012207.1 Differs from Rv1378c by 1aa, W37R, and from Mb1413c by 1aa, R9H in BCG Pasteur and BCG Tokyo; hypothetical protein 1550701 7563673 JTY_1414 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644470.1 1549274 R 561275 CDS YP_002644471.1 224989784 7563674 1550700..1551281 1 NC_012207.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase 1551281 pyrR 7563674 pyrR Mycobacterium bovis BCG str. Tokyo 172 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase YP_002644471.1 1550700 D 561275 CDS YP_002644472.1 224989785 7561544 1551278..1552237 1 NC_012207.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 1552237 pyrB 7561544 pyrB Mycobacterium bovis BCG str. Tokyo 172 aspartate carbamoyltransferase YP_002644472.1 1551278 D 561275 CDS YP_002644473.1 224989786 7560870 1552234..1553526 1 NC_012207.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1553526 pyrC 7560870 pyrC Mycobacterium bovis BCG str. Tokyo 172 dihydroorotase YP_002644473.1 1552234 D 561275 CDS YP_002644474.1 224989787 7560871 1553523..1554020 1 NC_012207.1 export or membrane protein 1554020 7560871 JTY_1418 Mycobacterium bovis BCG str. Tokyo 172 export or membrane protein YP_002644474.1 1553523 D 561275 CDS YP_002644475.1 224989788 7563675 1554017..1555147 1 NC_012207.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1555147 carA 7563675 carA Mycobacterium bovis BCG str. Tokyo 172 carbamoyl phosphate synthase small subunit YP_002644475.1 1554017 D 561275 CDS YP_002644476.1 224989789 7562082 1555147..1558494 1 NC_012207.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1558494 carB 7562082 carB Mycobacterium bovis BCG str. Tokyo 172 carbamoyl phosphate synthase large subunit YP_002644476.1 1555147 D 561275 CDS YP_002644477.1 224989790 7562083 1558491..1559315 1 NC_012207.1 type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1559315 pyrF 7562083 pyrF Mycobacterium bovis BCG str. Tokyo 172 orotidine 5'-phosphate decarboxylase YP_002644477.1 1558491 D 561275 CDS YP_002644478.1 224989791 7560874 1559510..1559818 1 NC_012207.1 PE family protein 1559818 PE15 7560874 PE15 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002644478.1 1559510 D 561275 CDS YP_002644479.1 224989792 7561715 1559815..1561434 1 NC_012207.1 Differs from Rv1387 by 1aa, A94V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PPE family protein 1561434 PPE20 7561715 PPE20 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644479.1 1559815 D 561275 CDS YP_002644480.1 224989793 7562157 1561740..1562312 1 NC_012207.1 integration host factor 1562312 mihF 7562157 mihF Mycobacterium bovis BCG str. Tokyo 172 integration host factor YP_002644480.1 1561740 D 561275 CDS YP_002644481.1 224989794 7564474 1562447..1563073 1 NC_012207.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1563073 gmk 7564474 gmk Mycobacterium bovis BCG str. Tokyo 172 guanylate kinase YP_002644481.1 1562447 D 561275 CDS YP_002644482.1 224989795 7563271 1563139..1563471 1 NC_012207.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1563471 rpoZ 7563271 rpoZ Mycobacterium bovis BCG str. Tokyo 172 DNA-directed RNA polymerase subunit omega YP_002644482.1 1563139 D 561275 CDS YP_002644483.1 224989796 7560727 1563487..1564743 1 NC_012207.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 1564743 dfp 7560727 dfp Mycobacterium bovis BCG str. Tokyo 172 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_002644483.1 1563487 D 561275 CDS YP_002644484.1 224989797 7561489 1564871..1566082 1 NC_012207.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1566082 metK 7561489 metK Mycobacterium bovis BCG str. Tokyo 172 S-adenosylmethionine synthetase YP_002644484.1 1564871 D 561275 CDS YP_002644485.1 224989798 7564462 complement(1566155..1567633) 1 NC_012207.1 monooxygenase 1567633 7564462 JTY_1429 Mycobacterium bovis BCG str. Tokyo 172 monooxygenase YP_002644485.1 1566155 R 561275 CDS YP_002644486.1 224989799 7562200 complement(1567630..1569015) 1 NC_012207.1 Differs from Rv1394c by 1aa, L135R in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cytochrome P450 132 1569015 cyp132 7562200 cyp132 Mycobacterium bovis BCG str. Tokyo 172 cytochrome P450 132 YP_002644486.1 1567630 R 561275 CDS YP_002644487.1 224989800 7563159 1569093..1570127 1 NC_012207.1 transcriptional regulatory protein 1570127 7563159 JTY_1431 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644487.1 1569093 D 561275 CDS YP_002644488.1 224989801 7562201 complement(1570173..1571531) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 372 bp deletion leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (452 aa versus 576 aa). Differs from Rv1396c by 2 aa, S66R, H300R in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; PE-PGRS family protein 1571531 PE_PGRS25 7562201 PE_PGRS25 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644488.1 1570173 R 561275 CDS YP_002644489.1 224989802 7561766 complement(1571786..1572187) 1 NC_012207.1 Differs from Rv1397c by 1aa, G103D in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 1572187 7561766 JTY_1433 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644489.1 1571786 R 561275 CDS YP_002644490.1 224989803 7562202 complement(1572184..1572441) 1 NC_012207.1 hypothetical protein 1572441 7562202 JTY_1434 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644490.1 1572184 R 561275 CDS YP_002644491.1 224989804 7562203 complement(1572524..1573483) 1 NC_012207.1 Differs from Rv1399c and Mb1434c by 1aa, A46P in BCG Pasteur and BCG Tokyo; lipase 1573483 lipH 7562203 lipH Mycobacterium bovis BCG str. Tokyo 172 lipase YP_002644491.1 1572524 R 561275 CDS YP_002644492.1 224989805 7562836 complement(1573508..1574470) 1 NC_012207.1 lipase 1574470 lipI 7562836 lipI Mycobacterium bovis BCG str. Tokyo 172 lipase YP_002644492.1 1573508 R 561275 CDS YP_002644493.1 224989806 7562837 1574604..1575206 1 NC_012207.1 hypothetical protein 1575206 7562837 JTY_1437 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644493.1 1574604 D 561275 CDS YP_002644494.1 224989807 7562204 1575287..1577254 1 NC_012207.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 1577254 priA 7562204 priA Mycobacterium bovis BCG str. Tokyo 172 primosome assembly protein PriA YP_002644494.1 1575287 D 561275 CDS YP_002644495.1 224989808 7560823 complement(1577272..1578096) 1 NC_012207.1 methyltransferase 1578096 7560823 JTY_1439 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase YP_002644495.1 1577272 R 561275 CDS YP_002644496.1 224989809 7562205 1578265..1578747 1 NC_012207.1 transcriptional regulatory protein 1578747 7562205 JTY_1440 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644496.1 1578265 D 561275 CDS YP_002644497.1 224989810 7562206 complement(1578819..1579643) 1 NC_012207.1 methyltransferase 1579643 7562206 JTY_1441 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase YP_002644497.1 1578819 R 561275 CDS YP_002644498.1 224989811 7562207 1579840..1580778 1 NC_012207.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1580778 fmt 7562207 fmt Mycobacterium bovis BCG str. Tokyo 172 methionyl-tRNA formyltransferase YP_002644498.1 1579840 D 561275 CDS YP_002644499.1 224989812 7563417 1580775..1582148 1 NC_012207.1 Differs from Rv1407 by 1aa, L427I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; fmu protein 1582148 fmu 7563417 fmu Mycobacterium bovis BCG str. Tokyo 172 fmu protein YP_002644499.1 1580775 D 561275 CDS YP_002644500.1 224989813 7563418 1582173..1582871 1 NC_012207.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 1582871 rpe 7563418 rpe Mycobacterium bovis BCG str. Tokyo 172 ribulose-phosphate 3-epimerase YP_002644500.1 1582173 D 561275 CDS YP_002644501.1 224989814 7561595 1582868..1583887 1 NC_012207.1 Differs from Rv1409 by 2aa, N30K, T71A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; diaminohydroxyphosphoribosylaminopyrimidine deaminase, 5-amino-6-(5-phosphoribosylamino) uracil reductase; riboflavin biosynthesis protein 1583887 ribG 7561595 ribG Mycobacterium bovis BCG str. Tokyo 172 riboflavin biosynthesis protein YP_002644501.1 1582868 D 561275 CDS YP_002644502.1 224989815 7561576 complement(1583884..1585440) 1 NC_012207.1 P55; aminoglycosides/tetracycline-transport integral membrane protein 1585440 7561576 JTY_1446 Mycobacterium bovis BCG str. Tokyo 172 aminoglycosides/tetracycline-transport integral membrane protein YP_002644502.1 1583884 R 561275 CDS YP_002644503.1 224989816 7562208 complement(1585446..1586156) 1 NC_012207.1 lipoprotein 1586156 lprG 7562208 lprG Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644503.1 1585446 R 561275 CDS YP_002644504.1 224989817 7560525 1586241..1586846 1 NC_012207.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1586846 ribC 7560525 ribC Mycobacterium bovis BCG str. Tokyo 172 riboflavin synthase subunit alpha YP_002644504.1 1586241 D 561275 CDS YP_002644505.1 224989818 7561573 1587060..1587575 1 NC_012207.1 hypothetical protein 1587575 7561573 JTY_1449 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644505.1 1587060 D 561275 CDS YP_002644506.1 224989819 7562209 1587565..1587966 1 NC_012207.1 hypothetical protein 1587966 7562209 JTY_1450 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644506.1 1587565 D 561275 CDS YP_002644507.1 224989820 7562210 1588071..1589348 1 NC_012207.1 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein 1589348 ribA2 7562210 ribA2 Mycobacterium bovis BCG str. Tokyo 172 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein YP_002644507.1 1588071 D 561275 CDS YP_002644508.1 224989821 7561572 1589363..1589827 1 NC_012207.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 1589827 ribH 7561572 ribH Mycobacterium bovis BCG str. Tokyo 172 6,7-dimethyl-8-ribityllumazine synthase YP_002644508.1 1589363 D 561275 CDS YP_002644509.1 224989822 7561577 1589824..1590288 1 NC_012207.1 hypothetical protein 1590288 7561577 JTY_1453 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644509.1 1589824 D 561275 CDS YP_002644510.1 224989823 7562211 1590313..1590999 1 NC_012207.1 lipoprotein 1590999 lprH 7562211 lprH Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644510.1 1590313 D 561275 CDS YP_002644511.1 224989824 7560526 1591179..1591652 1 NC_012207.1 hypothetical protein 1591652 7560526 JTY_1455 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644511.1 1591179 D 561275 CDS YP_002644512.1 224989825 7562212 1591716..1593656 1 NC_012207.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1593656 uvrC 7562212 uvrC Mycobacterium bovis BCG str. Tokyo 172 excinuclease ABC subunit C YP_002644512.1 1591716 D 561275 CDS YP_002644513.1 224989826 7561674 1593653..1594558 1 NC_012207.1 hypothetical protein 1594558 7561674 JTY_1457 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644513.1 1593653 D 561275 CDS YP_002644514.1 224989827 7562213 1594555..1595583 1 NC_012207.1 Differs from Mb1457 by 1aa, A86V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1595583 7562213 JTY_1458 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644514.1 1594555 D 561275 CDS YP_002644515.1 224989828 7562214 1595580..1596557 1 NC_012207.1 transcriptional regulatory protein 1596557 whiA 7562214 whiA Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644515.1 1595580 D 561275 CDS YP_002644516.1 224989829 7561688 complement(1596567..1597328) 1 NC_012207.1 hypothetical protein 1597328 7561688 JTY_1460 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644516.1 1596567 R 561275 CDS YP_002644517.1 224989830 7562215 1597332..1598711 1 NC_012207.1 Differs from Rv1425 by 1aa, L343P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1598711 7562215 JTY_1461 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644517.1 1597332 D 561275 CDS YP_002644518.1 224989831 7562216 complement(1598733..1599995) 1 NC_012207.1 esterase 1599995 lipO 7562216 lipO Mycobacterium bovis BCG str. Tokyo 172 esterase YP_002644518.1 1598733 R 561275 CDS YP_002644519.1 224989832 7562842 complement(1599995..1601602) 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1601602 fadD12 7562842 fadD12 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002644519.1 1599995 R 561275 CDS YP_002644520.1 224989833 7562918 complement(1601606..1602433) 1 NC_012207.1 hypothetical protein 1602433 7562918 JTY_1464 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644520.1 1601606 R 561275 CDS YP_002644521.1 224989834 7562217 1602552..1603820 1 NC_012207.1 hypothetical protein 1603820 7562217 JTY_1465 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644521.1 1602552 D 561275 CDS YP_002644522.1 224989835 7562218 1604060..1605646 1 NC_012207.1 PE family protein 1605646 PE16 7562218 PE16 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002644522.1 1604060 D 561275 CDS YP_002644523.1 224989836 7561716 1605757..1607526 1 NC_012207.1 Differs from Rv1431 by 2aa, T65N, Q455K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1607526 7561716 JTY_1467 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644523.1 1605757 D 561275 CDS YP_002644524.1 224989837 7562219 1607523..1608944 1 NC_012207.1 dehydrogenase 1608944 7562219 JTY_1468 Mycobacterium bovis BCG str. Tokyo 172 dehydrogenase YP_002644524.1 1607523 D 561275 CDS YP_002644525.1 224989838 7562220 1609108..1609929 1 NC_012207.1 Differs from Rv1433 and Mb1468 at C-terminal end due to 1bp deletion at position equivalent to H37Rv 1612222-1612222 in Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 1609929 7562220 JTY_1469 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644525.1 1609108 D 561275 CDS YP_002644526.1 224989839 7562221 1609929..1610066 1 NC_012207.1 hypothetical protein 1610066 7562221 JTY_1470 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644526.1 1609929 D 561275 CDS YP_002644527.1 224989840 7562222 complement(1610015..1610644) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, an in-frame insertion of 21 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (209 aa versus 202 aa). Differs from Rv1435c by 1aa, T67A in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; proline, glycine, valine-rich hypothetical protein 1610644 7562222 JTY_1471 Mycobacterium bovis BCG str. Tokyo 172 proline, glycine, valine-rich hypothetical protein YP_002644527.1 1610015 R 561275 CDS YP_002644528.1 224989841 7562223 1611001..1612020 1 NC_012207.1 glyceraldehyde 3-phosphate dehydrogenase 1612020 gap 7562223 gap Mycobacterium bovis BCG str. Tokyo 172 glyceraldehyde 3-phosphate dehydrogenase YP_002644528.1 1611001 D 561275 CDS YP_002644529.1 224989842 7561902 1612023..1613261 1 NC_012207.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 1613261 pgk 7561902 pgk Mycobacterium bovis BCG str. Tokyo 172 phosphoglycerate kinase YP_002644529.1 1612023 D 561275 CDS YP_002644530.1 224989843 7562399 1613258..1614043 1 NC_012207.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1614043 tpiA 7562399 tpiA Mycobacterium bovis BCG str. Tokyo 172 triosephosphate isomerase YP_002644530.1 1613258 D 561275 CDS YP_002644531.1 224989844 7561864 complement(1614655..1615080) 1 NC_012207.1 hypothetical protein 1615080 7561864 JTY_1475 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644531.1 1614655 R 561275 CDS YP_002644532.1 224989845 7562224 1615531..1615764 1 NC_012207.1 preprotein translocase subunit SecG 1615764 secG 7562224 secG Mycobacterium bovis BCG str. Tokyo 172 preprotein translocase subunit SecG YP_002644532.1 1615531 D 561275 CDS YP_002644533.1 224989846 7560776 complement(1615903..1617378) 1 NC_012207.1 Differs from Rv1441c by 1aa G236D and from Mb1476c by 1aa T354N in BCG Pasteur and BCG Tokyo; PE-PGRS family protein 1617378 PE_PGRS26 7560776 PE_PGRS26 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644533.1 1615903 R 561275 CDS YP_002644534.1 224989847 7561767 1617485..1619785 1 NC_012207.1 biotin sulfoxide reductase 1619785 bisC 7561767 bisC Mycobacterium bovis BCG str. Tokyo 172 biotin sulfoxide reductase YP_002644534.1 1617485 D 561275 CDS YP_002644535.1 224989848 7562072 complement(1619901..1620386) 1 NC_012207.1 hypothetical protein 1620386 7562072 JTY_1479 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644535.1 1619901 R 561275 CDS YP_002644536.1 224989849 7562225 complement(1620993..1621403) 1 NC_012207.1 hypothetical protein 1621403 7562225 JTY_1480 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644536.1 1620993 R 561275 CDS YP_002644537.1 224989850 7562226 complement(1621420..1622163) 1 NC_012207.1 6-phosphogluconolactonase 1622163 devB 7562226 devB Mycobacterium bovis BCG str. Tokyo 172 6-phosphogluconolactonase YP_002644537.1 1621420 R 561275 CDS YP_002644538.1 224989851 7561486 complement(1622160..1623071) 1 NC_012207.1 Differs from Rv1446v by 1aa P192R in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; OxpP cycle protein 1623071 opcA 7561486 opcA Mycobacterium bovis BCG str. Tokyo 172 OxpP cycle protein YP_002644538.1 1622160 R 561275 CDS YP_002644539.1 224989852 7562495 complement(1623124..1624668) 1 NC_012207.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1624668 zwf2 7562495 zwf2 Mycobacterium bovis BCG str. Tokyo 172 glucose-6-phosphate 1-dehydrogenase YP_002644539.1 1623124 R 561275 CDS YP_002644540.1 224989853 7561458 complement(1624665..1625786) 1 NC_012207.1 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase 1625786 tal 7561458 tal Mycobacterium bovis BCG str. Tokyo 172 transaldolase YP_002644540.1 1624665 R 561275 CDS YP_002644541.1 224989854 7561821 complement(1625803..1627905) 1 NC_012207.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1627905 tkt 7561821 tkt Mycobacterium bovis BCG str. Tokyo 172 transketolase YP_002644541.1 1625803 R 561275 CDS YP_002644542.1 224989855 7561860 complement(1628344..1632543) 1 NC_012207.1 In Mycobacterium bovis, insertions of 27 bp, 207 bpand 27 bp, substitutions of 60 bp to 63 bp and 11 bp, and a 27 bp deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (1408 aa versus 1329 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, one 27bp-insertion is missing, leading to a product of 1399 aa; PE-PGRS family protein 1632543 PE_PGRS27 7561860 PE_PGRS27 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644542.1 1628344 R 561275 CDS YP_002644543.1 224989856 7561768 1632945..1633871 1 NC_012207.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 1633871 ctaB 7561768 ctaB Mycobacterium bovis BCG str. Tokyo 172 protoheme IX farnesyltransferase YP_002644543.1 1632945 D 561275 CDS YP_002644544.1 224989857 7563127 complement(1633920..1636142) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur and Tokyo, a insertion of 51 bp, several substitutions and a deletion of 207 bp, lead to a smaller product compared to its homolog Mycobacterium bovis (740 aa versus 795 aa). Differs from BCG_1513c by 5aa, G647D, G648I, D649I, G650V, T651A in BCG Tokyo.; PE-PGRS family protein 1636142 PE_PGRS28 7563127 PE_PGRS28 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644544.1 1633920 R 561275 CDS YP_002644545.1 224989858 7561769 1636294..1637559 1 NC_012207.1 Differs from Rv1453 by 1aa Q405P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional activator protein 1637559 7561769 JTY_1489 Mycobacterium bovis BCG str. Tokyo 172 transcriptional activator protein YP_002644545.1 1636294 D 561275 CDS YP_002644546.1 224989859 7562227 complement(1637587..1638573) 1 NC_012207.1 quinone reductase 1638573 qor 7562227 qor Mycobacterium bovis BCG str. Tokyo 172 quinone reductase YP_002644546.1 1637587 R 561275 CDS YP_002644547.1 224989860 7561548 1638593..1639456 1 NC_012207.1 hypothetical protein 1639456 7561548 JTY_1491 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644547.1 1638593 D 561275 CDS YP_002644548.1 224989861 7562228 complement(1639406..1640338) 1 NC_012207.1 unidentified antibiotic-transport integral membrane ABC transporter 1640338 7562228 JTY_1492 Mycobacterium bovis BCG str. Tokyo 172 unidentified antibiotic-transport integral membrane ABC transporter YP_002644548.1 1639406 R 561275 CDS YP_002644549.1 224989862 7562229 complement(1640450..1641235) 1 NC_012207.1 unidentified antibiotic-transport integral membrane ABC transporter 1641235 7562229 JTY_1493 Mycobacterium bovis BCG str. Tokyo 172 unidentified antibiotic-transport integral membrane ABC transporter YP_002644549.1 1640450 R 561275 CDS YP_002644550.1 224989863 7562230 complement(1641232..1642173) 1 NC_012207.1 unidentified antibiotic-transport ATP-binding protein ABC transporter 1642173 7562230 JTY_1494 Mycobacterium bovis BCG str. Tokyo 172 unidentified antibiotic-transport ATP-binding protein ABC transporter YP_002644550.1 1641232 R 561275 CDS YP_002644551.1 224989864 7562231 complement(1642329..1644104) 1 NC_012207.1 Differs from Rv1459c by 1aa, E113K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 1644104 7562231 JTY_1495 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002644551.1 1642329 R 561275 CDS YP_002644552.1 224989865 7562232 1644152..1644958 1 NC_012207.1 Differs from Rv1460 by 2aa, F198I, V265 and from Mb1495 by 1aa, F198I in BCG Paasteur and BCG Tokyo; transcriptional regulatory protein 1644958 7562232 JTY_1496 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644552.1 1644152 D 561275 CDS YP_002644553.1 224989866 7562233 1644955..1647495 1 NC_012207.1 hypothetical protein 1647495 7562233 JTY_1497 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644553.1 1644955 D 561275 CDS YP_002644554.1 224989867 7562234 1647492..1648685 1 NC_012207.1 Differs from Rv1462 by 1aa, D183N in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1648685 7562234 JTY_1498 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644554.1 1647492 D 561275 CDS YP_002644555.1 224989868 7562235 1648682..1649482 1 NC_012207.1 ATP-binding protein ABC transporter 1649482 7562235 JTY_1499 Mycobacterium bovis BCG str. Tokyo 172 ATP-binding protein ABC transporter YP_002644555.1 1648682 D 561275 CDS YP_002644556.1 224989869 7562236 1649484..1650737 1 NC_012207.1 cysteine desulfurase 1650737 csd 7562236 csd Mycobacterium bovis BCG str. Tokyo 172 cysteine desulfurase YP_002644556.1 1649484 D 561275 CDS YP_002644557.1 224989870 7563123 1650734..1651222 1 NC_012207.1 nitrogen fixation related protein 1651222 7563123 JTY_1501 Mycobacterium bovis BCG str. Tokyo 172 nitrogen fixation related protein YP_002644557.1 1650734 D 561275 CDS YP_002644558.1 224989871 7562237 1651197..1651544 1 NC_012207.1 hypothetical protein 1651544 7562237 JTY_1502 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644558.1 1651197 D 561275 CDS YP_002644559.1 224989872 7562238 complement(1651639..1653468) 1 NC_012207.1 acyl-CoA dehydrogenase 1653468 fadE15 7562238 fadE15 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002644559.1 1651639 R 561275 CDS YP_002644560.1 224989873 7563363 complement(1653575..1654687) 1 NC_012207.1 PE-PGRS family protein 1654687 PE_PGRS29 7563363 PE_PGRS29 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644560.1 1653575 R 561275 CDS YP_002644561.1 224989874 7561770 1654929..1656902 1 NC_012207.1 cation transporter P-type ATPase D 1656902 ctpD 7561770 ctpD Mycobacterium bovis BCG str. Tokyo 172 cation transporter P-type ATPase D YP_002644561.1 1654929 D 561275 CDS YP_002644562.1 224989875 7563134 1656946..1657320 1 NC_012207.1 thioredoxin 1657320 trxA 7563134 trxA Mycobacterium bovis BCG str. Tokyo 172 thioredoxin YP_002644562.1 1656946 D 561275 CDS YP_002644563.1 224989876 7561638 1657336..1657707 1 NC_012207.1 thioredoxin 1657707 trxB1 7561638 trxB1 Mycobacterium bovis BCG str. Tokyo 172 thioredoxin YP_002644563.1 1657336 D 561275 CDS YP_002644564.1 224989877 7561639 1657729..1658586 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1658586 echA12 7561639 echA12 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002644564.1 1657729 D 561275 CDS YP_002644565.1 224989878 7561524 1658622..1660250 1 NC_012207.1 macrolide-transport ATP-binding protein ABC transporter 1660250 7561524 JTY_1509 Mycobacterium bovis BCG str. Tokyo 172 macrolide-transport ATP-binding protein ABC transporter YP_002644565.1 1658622 D 561275 CDS YP_002644566.1 224989879 7562239 1660347..1660538 1 NC_012207.1 Differs from Rv1473A by 1aa, P60S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional regulatory protein 1660538 7562239 JTY_1510 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644566.1 1660347 D 561275 CDS YP_002644567.1 224989880 7562240 complement(1660607..1661170) 1 NC_012207.1 transcriptional regulatory protein 1661170 7562240 JTY_1511 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644567.1 1660607 R 561275 CDS YP_002644568.1 224989881 7562241 complement(1661181..1664012) 1 NC_012207.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1664012 acn 7562241 acn Mycobacterium bovis BCG str. Tokyo 172 aconitate hydratase YP_002644568.1 1661181 R 561275 CDS YP_002644569.1 224989882 7563930 1664170..1664730 1 NC_012207.1 hypothetical protein 1664730 7563930 JTY_1513 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644569.1 1664170 D 561275 CDS YP_002644570.1 224989883 7562242 1664956..1666374 1 NC_012207.1 hypothetical invasion protein 1666374 7562242 JTY_1514 Mycobacterium bovis BCG str. Tokyo 172 hypothetical invasion protein YP_002644570.1 1664956 D 561275 CDS YP_002644571.1 224989884 7562243 1666385..1667110 1 NC_012207.1 hypothetical invasion protein 1667110 7562243 JTY_1515 Mycobacterium bovis BCG str. Tokyo 172 hypothetical invasion protein YP_002644571.1 1666385 D 561275 CDS YP_002644572.1 224989885 7562244 1667249..1668382 1 NC_012207.1 transcriptional regulatory protein 1668382 moxR1 7562244 moxR1 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644572.1 1667249 D 561275 CDS YP_002644573.1 224989886 7563547 1668379..1669332 1 NC_012207.1 hypothetical protein 1669332 7563547 JTY_1517 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644573.1 1668379 D 561275 CDS YP_002644574.1 224989887 7562245 1669343..1670350 1 NC_012207.1 Differs from Rv1481 and Mb1517 by 1aa, D254N in BCG Pasteur and BCG Tokyo; hypothetical protein 1670350 7562245 JTY_1518 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644574.1 1669343 D 561275 CDS YP_002644575.1 224989888 7562246 complement(1670423..1671265) 1 NC_012207.1 hypothetical protein 1671265 7562246 JTY_1519 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644575.1 1670423 R 561275 CDS YP_002644576.1 224989889 7562247 1671406..1672149 1 NC_012207.1 3-oxoacyl-ACP reductase 1672149 fabG1 7562247 fabG1 Mycobacterium bovis BCG str. Tokyo 172 3-oxoacyl-ACP reductase YP_002644576.1 1671406 D 561275 CDS YP_002644577.1 224989890 7562900 1672168..1672977 1 NC_012207.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 1672977 inhA 7562900 inhA Mycobacterium bovis BCG str. Tokyo 172 enoyl-(acyl carrier protein) reductase YP_002644577.1 1672168 D 561275 CDS YP_002644578.1 224989891 7562788 1672983..1674017 1 NC_012207.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 1674017 hemH 7562788 hemH Mycobacterium bovis BCG str. Tokyo 172 ferrochelatase YP_002644578.1 1672983 D 561275 CDS YP_002644579.1 224989892 7563306 complement(1673983..1674849) 1 NC_012207.1 First 270 aa identical to Mb1522c and Rv1486c (but differs by 1aa, N198K), then frameshifts due to extra base, g, at position equivalent to Mycobacterium tuberculosis strain H37Rv position 1676073-1676074. 2GC in BCG Tokyo, 1GC in BCG Pasteur.; hypothetical protein 1674849 7563306 JTY_1523 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644579.1 1673983 R 561275 CDS YP_002644580.1 224989893 7562248 1674907..1675341 1 NC_012207.1 hypothetical protein 1675341 7562248 JTY_1524 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644580.1 1674907 D 561275 CDS YP_002644581.1 224989894 7562249 1675363..1676508 1 NC_012207.1 exported conserved protein 1676508 7562249 JTY_1525 Mycobacterium bovis BCG str. Tokyo 172 exported conserved protein YP_002644581.1 1675363 D 561275 CDS YP_002644582.1 224989895 7562250 1676518..1676874 1 NC_012207.1 hypothetical protein 1676874 7562250 JTY_1526 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644582.1 1676518 D 561275 CDS YP_002644583.1 224989896 7562251 1676908..1677138 1 NC_012207.1 hypothetical protein 1677138 7562251 JTY_1527 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644583.1 1676908 D 561275 CDS YP_002644584.1 224989897 7562252 1677288..1678595 1 NC_012207.1 hypothetical protein 1678595 7562252 JTY_1528 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644584.1 1677288 D 561275 CDS YP_002644585.1 224989898 7562253 complement(1679174..1679932) 1 NC_012207.1 hypothetical protein 1679932 7562253 JTY_1529 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644585.1 1679174 R 561275 CDS YP_002644586.1 224989899 7562254 1680123..1681970 1 NC_012207.1 methylmalonyl-CoA mutase small subunit 1681970 mutA 7562254 mutA Mycobacterium bovis BCG str. Tokyo 172 methylmalonyl-CoA mutase small subunit YP_002644586.1 1680123 D 561275 CDS YP_002644587.1 224989900 7563579 1681971..1684223 1 NC_012207.1 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 1684223 mutB 7563579 mutB Mycobacterium bovis BCG str. Tokyo 172 methylmalonyl-CoA mutase YP_002644587.1 1681971 D 561275 CDS YP_002644588.1 224989901 7563580 1684237..1684539 1 NC_012207.1 Differs from Rv1494 and Mb1531 by 1aa, L12S in BCG Pasteur and BCG Tokyo; hypothetical protein 1684539 7563580 JTY_1532 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644588.1 1684237 D 561275 CDS YP_002644589.1 224989902 7562255 1684536..1684853 1 NC_012207.1 hypothetical protein 1684853 7562255 JTY_1533 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644589.1 1684536 D 561275 CDS YP_002644590.1 224989903 7562256 1684850..1685854 1 NC_012207.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 1685854 7562256 JTY_1534 Mycobacterium bovis BCG str. Tokyo 172 arginine/ornithine transport system ATPase YP_002644590.1 1684850 D 561275 CDS YP_002644591.1 224989904 7562257 1685907..1687196 1 NC_012207.1 esterase 1687196 lipL 7562257 lipL Mycobacterium bovis BCG str. Tokyo 172 esterase YP_002644591.1 1685907 D 561275 CDS YP_002644592.1 224989905 7562839 complement(1687269..1687886) 1 NC_012207.1 Differs from Rv1498c by 1aa, H191R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methyltransferase 1687886 7562839 JTY_1536 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase YP_002644592.1 1687269 R 561275 CDS YP_002644593.1 224989906 7562258 complement(1688100..1688291) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (a-g) at the 5' start leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (63 aa versus 70 aa); hypothetical protein 1688291 7562258 JTY_1537 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644593.1 1688100 R 561275 CDS YP_002644594.1 224989907 7562259 1688373..1688771 1 NC_012207.1 hypothetical protein 1688771 7562259 JTY_1538 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644594.1 1688373 D 561275 CDS YP_002644595.1 224989908 7562260 1688816..1689844 1 NC_012207.1 Differs from Rv1500 and Mb1538 by 1aa, E45D in BCG Pasteur and BCG Tokyo; glycosyltransferase 1689844 7562260 JTY_1539 Mycobacterium bovis BCG str. Tokyo 172 glycosyltransferase YP_002644595.1 1688816 D 561275 CDS YP_002644596.1 224989909 7562261 1689856..1690677 1 NC_012207.1 hypothetical protein 1690677 7562261 JTY_1540 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644596.1 1689856 D 561275 CDS YP_002644597.1 224989910 7562262 1690890..1691789 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, Rv1502 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (T-*), splits Rv1502 into 2 parts, Mb1540 and Mb1541. Differs from Rv1502 by 1aa, C213Y in BCG Pasteur and BCG Tokyo; hypothetical protein 1691789 7562262 JTY_1541 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644597.1 1690890 D 561275 CDS YP_002644598.1 224989911 7562263 complement(1691962..1693110) 1 NC_012207.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 1693110 7562263 JTY_1542 Mycobacterium bovis BCG str. Tokyo 172 TDP-4-oxo-6-deoxy-D-glucose transaminase YP_002644598.1 1691962 R 561275 CDS YP_002644599.1 224989912 7562264 complement(1693247..1693912) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1503c and Rv1504c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transversion (T-G) leads to a single product. Differs from Rv1503c by 1aa, K316E in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 1693912 7562264 JTY_1543 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644599.1 1693247 R 561275 CDS YP_002644600.1 224989913 7562265 1694105..1694869 1 NC_012207.1 Differs from Rv1517 by 1aa, F188L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1694869 7562265 JTY_1544 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644600.1 1694105 D 561275 CDS YP_002644601.1 224989914 7562266 1694878..1695837 1 NC_012207.1 Differs from Rv1518 by 2aa, R266S, L317M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1695837 7562266 JTY_1545 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644601.1 1694878 D 561275 CDS YP_002644602.1 224989915 7562267 1695967..1696236 1 NC_012207.1 hypothetical protein 1696236 7562267 JTY_1546 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644602.1 1695967 D 561275 CDS YP_002644603.1 224989916 7562268 1696262..1697302 1 NC_012207.1 sugar transferase 1697302 7562268 JTY_1547 Mycobacterium bovis BCG str. Tokyo 172 sugar transferase YP_002644603.1 1696262 D 561275 CDS YP_002644604.1 224989917 7562269 1697536..1699287 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1699287 fadD25 7562269 fadD25 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002644604.1 1697536 D 561275 CDS YP_002644605.1 224989918 7562931 complement(1699523..1702846) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transversion (C-A) creating a stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1107 aa versus 1146 aa). Differs from Rv1522c (1146 aa) by 1aa, P381S, and from Mb1549c, (1107 aa) by 2aa, T204A, S947N in BCG Pasteur and BCG Tokyo; transmembrane transport protein 1702846 mmpL12 7562931 mmpL12 Mycobacterium bovis BCG str. Tokyo 172 transmembrane transport protein YP_002644605.1 1699523 R 561275 CDS YP_002644606.1 224989919 7564482 1702887..1703930 1 NC_012207.1 methyltransferase 1703930 7564482 JTY_1550 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase YP_002644606.1 1702887 D 561275 CDS YP_002644607.1 224989920 7562270 1703960..1705204 1 NC_012207.1 glycosyltransferase 1705204 7562270 JTY_1551 Mycobacterium bovis BCG str. Tokyo 172 glycosyltransferase YP_002644607.1 1703960 D 561275 CDS YP_002644608.1 224989921 7562271 1705251..1706036 1 NC_012207.1 rhamnosyl transferase 1706036 wbbL2 7562271 wbbL2 Mycobacterium bovis BCG str. Tokyo 172 rhamnosyl transferase YP_002644608.1 1705251 D 561275 CDS YP_002644609.1 224989922 7561687 complement(1706014..1707294) 1 NC_012207.1 glycosyltransferase 1707294 7561687 JTY_1553 Mycobacterium bovis BCG str. Tokyo 172 glycosyltransferase YP_002644609.1 1706014 R 561275 CDS YP_002644610.1 224989923 7562272 complement(1707317..1713643) 1 NC_012207.1 Differs from Rv1527c by 2aa, T532P, L1439F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; polyketide synthase 1713643 pks5 7562272 pks5 Mycobacterium bovis BCG str. Tokyo 172 polyketide synthase YP_002644610.1 1707317 R 561275 CDS YP_002644611.1 224989924 7562121 complement(1714187..1714684) 1 NC_012207.1 polyketide synthase associated protein 1714684 papA4 7562121 papA4 Mycobacterium bovis BCG str. Tokyo 172 polyketide synthase associated protein YP_002644611.1 1714187 R 561275 CDS YP_002644612.1 224989925 7562514 1714736..1716490 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1716490 fadD24 7562514 fadD24 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002644612.1 1714736 D 561275 CDS YP_002644613.1 224989926 7562930 1716607..1717710 1 NC_012207.1 Differs from Rv1530 and Mb1557 by 1aa, L330P in BCG Pasteur and BCG Tokyo; alcohol dehydrogenase 1717710 adh 7562930 adh Mycobacterium bovis BCG str. Tokyo 172 alcohol dehydrogenase YP_002644613.1 1716607 D 561275 CDS YP_002644614.1 224989927 7563940 1717707..1718273 1 NC_012207.1 hypothetical protein 1718273 7563940 JTY_1558 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644614.1 1717707 D 561275 CDS YP_002644615.1 224989928 7562273 complement(1718350..1718784) 1 NC_012207.1 hypothetical protein 1718784 7562273 JTY_1559 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644615.1 1718350 R 561275 CDS YP_002644616.1 224989929 7562274 1718844..1719971 1 NC_012207.1 hypothetical protein 1719971 7562274 JTY_1560 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644616.1 1718844 D 561275 CDS YP_002644617.1 224989930 7562275 1719968..1720645 1 NC_012207.1 transcriptional regulator 1720645 7562275 JTY_1561 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulator YP_002644617.1 1719968 D 561275 CDS YP_002644618.1 224989931 7562276 1721210..1721446 1 NC_012207.1 hypothetical protein 1721446 7562276 JTY_1562 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644618.1 1721210 D 561275 CDS YP_002644619.1 224989932 7562277 1721753..1724878 1 NC_012207.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase 1724878 ileS 7562277 ileS Mycobacterium bovis BCG str. Tokyo 172 isoleucyl-tRNA synthetase YP_002644619.1 1721753 D 561275 CDS YP_002644620.1 224989933 7563347 1725090..1726481 1 NC_012207.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 1726481 dinX 7563347 dinX Mycobacterium bovis BCG str. Tokyo 172 DNA polymerase IV YP_002644620.1 1725090 D 561275 CDS YP_002644621.1 224989934 7561496 complement(1726446..1727426) 1 NC_012207.1 L-aparaginase 1727426 ansA 7561496 ansA Mycobacterium bovis BCG str. Tokyo 172 L-aparaginase YP_002644621.1 1726446 R 561275 CDS YP_002644622.1 224989935 7563976 1727478..1728086 1 NC_012207.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1728086 lspA 7563976 lspA Mycobacterium bovis BCG str. Tokyo 172 lipoprotein signal peptidase YP_002644622.1 1727478 D 561275 CDS YP_002644623.1 224989936 7560536 1728079..1729005 1 NC_012207.1 hypothetical protein 1729005 7560536 JTY_1567 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644623.1 1728079 D 561275 CDS YP_002644624.1 224989937 7562278 complement(1729012..1729605) 1 NC_012207.1 lipoprotein 1729605 lprI 7562278 lprI Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644624.1 1729012 R 561275 CDS YP_002644625.1 224989938 7560527 complement(1729660..1730070) 1 NC_012207.1 hemoglobin 1730070 glbN 7560527 glbN Mycobacterium bovis BCG str. Tokyo 172 hemoglobin YP_002644625.1 1729660 R 561275 CDS YP_002644626.1 224989939 7561916 1730298..1731323 1 NC_012207.1 fatty acyl-CoA reductase 1731323 7561916 JTY_1570 Mycobacterium bovis BCG str. Tokyo 172 fatty acyl-CoA reductase YP_002644626.1 1730298 D 561275 CDS YP_002644627.1 224989940 7562279 1731328..1732131 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, Rv1544 and Mb1571 exist as a single gene. In BCG Tokyo exists same as Rv1544 and Mb1571. In Mycobacterium bovis BCG Pasteur, two genes exist as a result of a 10 bp deletion that has occurred at a position equivalent to H37Rv position 1746147-1746156I; ketoacyl reductase 1732131 7562279 JTY_1571 Mycobacterium bovis BCG str. Tokyo 172 ketoacyl reductase YP_002644627.1 1731328 D 561275 CDS YP_002644628.1 224989941 7562280 1732153..1732380 1 NC_012207.1 hypothetical protein 1732380 7562280 JTY_1572 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644628.1 1732153 D 561275 CDS YP_002644629.1 224989942 7562281 1732429..1732860 1 NC_012207.1 hypothetical protein 1732860 7562281 JTY_1573 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644629.1 1732429 D 561275 CDS YP_002644630.1 224989943 7560548 1732928..1736482 1 NC_012207.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 1736482 dnaE 7560548 dnaE Mycobacterium bovis BCG str. Tokyo 172 DNA polymerase III subunit alpha YP_002644630.1 1732928 D 561275 CDS YP_002644631.1 224989944 7561501 complement(1736531..1738567) 1 NC_012207.1 Differs from Rv1548c by 1aa, G258D, and from Mb1575c by 1aa, V68A in BCG Pasteur and BCG Tokyo; PPE family protein 1738567 PPE21 7561501 PPE21 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644631.1 1736531 R 561275 CDS YP_002644632.1 224989945 7562158 1738724..1740667 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1549 and Rv1550 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, two single base insertions (*-C and *-C) lead to a single product. Differs from Rv1550 by 1aa, S362L in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; fatty-acid-CoA ligase 1740667 fadD11 7562158 fadD11 Mycobacterium bovis BCG str. Tokyo 172 fatty-acid-CoA ligase YP_002644632.1 1738724 D 561275 CDS YP_002644633.1 224989946 7562917 1740681..1742546 1 NC_012207.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 1742546 plsB1 7562917 plsB1 Mycobacterium bovis BCG str. Tokyo 172 glycerol-3-phosphate acyltransferase YP_002644633.1 1740681 D 561275 CDS YP_002644634.1 224989947 7562128 1742916..1744667 1 NC_012207.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 1744667 frdA 7562128 frdA Mycobacterium bovis BCG str. Tokyo 172 fumarate reductase flavoprotein subunit YP_002644634.1 1742916 D 561275 CDS YP_002644635.1 224989948 7563429 1744670..1745422 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1553 and Rv1554 exist as 2 genes. In Mycobacterium bovis (Mb1579), a 4bp insertion (*-GGGG) leads to a single product and in Mycobacterium bovis BCG Pasteur a 10 bp insertion at position equivalent to H37Rv 1760171-1760172 leads to insertion of two additional Gly codons. In Mycobacterium bovis BCG Tokyo, a 9 bp insertion at position equivalent to H37Rv 1760171-1760172 leads to insertion of three additional Gly codons. 16Gs in BCG Tokyo, 17Gs in BCG Pasteur.; iron-sulfur subunit frdB; fumarate reductase 1745422 frdB 7563429 frdB Mycobacterium bovis BCG str. Tokyo 172 fumarate reductase YP_002644635.1 1744670 D 561275 CDS YP_002644636.1 224989949 7561872 1745485..1745799 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1553 and Rv1554 exist as 2 genes. In Mycobacterium bovis, a 4bp insertion (*-GGGG) leads to a single product and in Mycobacterium bovis BCG Pasteur a 10 bp insertion at position equivalent to H37Rv 1760171-1760172 leads to insertion of two additional Gly codons. In Mycobacterium bovis BCG Tokyo, a 9 bp insertion at position equivalent to H37Rv 1760171-1760172 leads to insertion of three additional Gly codons.; membrane anchor subunit; fumarate reductase 1745799 frdC 7561872 frdC Mycobacterium bovis BCG str. Tokyo 172 fumarate reductase YP_002644636.1 1745485 D 561275 CDS YP_002644637.1 224989950 7561873 1745796..1746173 1 NC_012207.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 1746173 frdD 7561873 frdD Mycobacterium bovis BCG str. Tokyo 172 fumarate reductase subunit D YP_002644637.1 1745796 D 561275 CDS YP_002644638.1 224989951 7561874 1746241..1746849 1 NC_012207.1 regulatory protein 1746849 7561874 JTY_1582 Mycobacterium bovis BCG str. Tokyo 172 regulatory protein YP_002644638.1 1746241 D 561275 CDS YP_002644639.1 224989952 7560549 1746988..1747434 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 2153 bp insertion leads to a new protein with no equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to the TbD1 region; hypothetical protein 1747434 mmpS6 7560549 mmpS6 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644639.1 1746988 D 561275 CDS YP_002644640.1 224989953 7563516 1747431..1750334 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 2153 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Belongs to the TbD1 region; transmembrane transport protein 1750334 mmpL6 7563516 mmpL6 Mycobacterium bovis BCG str. Tokyo 172 transmembrane transport protein YP_002644640.1 1747431 D 561275 CDS YP_002644641.1 224989954 7564491 1750344..1750790 1 NC_012207.1 hypothetical protein 1750790 7564491 JTY_1585 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644641.1 1750344 D 561275 CDS YP_002644642.1 224989955 7560550 1750825..1752114 1 NC_012207.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 1752114 ilvA 7560550 ilvA Mycobacterium bovis BCG str. Tokyo 172 threonine dehydratase YP_002644642.1 1750825 D 561275 CDS YP_002644643.1 224989956 7562775 1752152..1752370 1 NC_012207.1 hypothetical protein 1752370 7562775 JTY_1587 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644643.1 1752152 D 561275 CDS YP_002644644.1 224989957 7560551 1752376..1752780 1 NC_012207.1 hypothetical protein 1752780 7560551 JTY_1588 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644644.1 1752376 D 561275 CDS YP_002644645.1 224989958 7560552 complement(1752797..1753357) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, treZa and treZb exist as a single gene, treZ. In Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base deletion at position equivalent to H37Rv 1766233-1766233 leads to frameshift and two genes, treZa and treZb; maltooligosyltrehalose trehalohydrolase 1753357 treZb 7560552 treZb Mycobacterium bovis BCG str. Tokyo 172 maltooligosyltrehalose trehalohydrolase YP_002644645.1 1752797 R 561275 CDS YP_002644646.1 224989959 7561625 complement(1753354..1754538) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, treZa and treZb exist as a single gene, treZ. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, a single base deletion at position equivalent to H37Rv 1766233-1766233 leads to frameshift and two genes, treZa and treZb; maltooligosyltrehalose trehalohydrolase 1754538 treZa 7561625 treZa Mycobacterium bovis BCG str. Tokyo 172 maltooligosyltrehalose trehalohydrolase YP_002644646.1 1753354 R 561275 CDS YP_002644647.1 224989960 7561871 complement(1754531..1756828) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and in Mycobacterium tuberculosis strain H37Rv, treY exists as a single gene. In Mycobacterium bovis, a large deletion of 806 bp, RD17, splits Rv1563c into two parts, treYa and treYb; maltooligosyltrehalose synthase 1756828 treY 7561871 treY Mycobacterium bovis BCG str. Tokyo 172 maltooligosyltrehalose synthase YP_002644647.1 1754531 R 561275 CDS YP_002644648.1 224989961 7561870 complement(1756832..1758997) 1 NC_012207.1 maltooligosyltrehalose synthase 1758997 treX 7561870 treX Mycobacterium bovis BCG str. Tokyo 172 maltooligosyltrehalose synthase YP_002644648.1 1756832 R 561275 CDS YP_002644649.1 224989962 7561869 complement(1759036..1761225) 1 NC_012207.1 hypothetical protein 1761225 7561869 JTY_1593 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644649.1 1759036 R 561275 CDS YP_002644650.1 224989963 7560553 complement(1761324..1762016) 1 NC_012207.1 inv protein 1762016 7560553 JTY_1594 Mycobacterium bovis BCG str. Tokyo 172 inv protein YP_002644650.1 1761324 R 561275 CDS YP_002644651.1 224989964 7560554 complement(1762256..1762540) 1 NC_012207.1 hypothetical protein 1762540 7560554 JTY_1595 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644651.1 1762256 R 561275 CDS YP_002644652.1 224989965 7560555 1762788..1764101 1 NC_012207.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1764101 bioA 7560555 bioA Mycobacterium bovis BCG str. Tokyo 172 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_002644652.1 1762788 D 561275 CDS YP_002644653.1 224989966 7562066 1764098..1765258 1 NC_012207.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 1765258 bioF1 7562066 bioF1 Mycobacterium bovis BCG str. Tokyo 172 8-amino-7-oxononanoate synthase YP_002644653.1 1764098 D 561275 CDS YP_002644654.1 224989967 7562069 1765255..1765935 1 NC_012207.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1765935 bioD 7562069 bioD Mycobacterium bovis BCG str. Tokyo 172 dithiobiotin synthetase YP_002644654.1 1765255 D 561275 CDS YP_002644655.1 224989968 7562068 1765935..1766444 1 NC_012207.1 hypothetical protein 1766444 7562068 JTY_1599 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644655.1 1765935 D 561275 CDS YP_002644656.1 224989969 7560556 complement(1766590..1767546) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis, Rv1587c possibly exists as a pseudogene that has been disrupted when the phage entered. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, the prophage is absent and the C-terminal part of protein differs accordingly; partial REP13E12 repeat protein 1767546 7560556 JTY_1600 Mycobacterium bovis BCG str. Tokyo 172 partial REP13E12 repeat protein YP_002644656.1 1766590 R 561275 CDS YP_002644657.1 224989970 7560557 complement(1767317..1767985) 1 NC_012207.1 Differs from Rv1588c by 3aa, T63A, L91R, I131V; partial REP13E12 repeat protein 1767985 7560557 JTY_1601 Mycobacterium bovis BCG str. Tokyo 172 partial REP13E12 repeat protein YP_002644657.1 1767317 R 561275 CDS YP_002644658.1 224989971 7560558 1768433..1769482 1 NC_012207.1 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase 1769482 bioB 7560558 bioB Mycobacterium bovis BCG str. Tokyo 172 biotin synthase YP_002644658.1 1768433 D 561275 CDS YP_002644659.1 224989972 7562067 1769483..1769722 1 NC_012207.1 hypothetical protein 1769722 7562067 JTY_1603 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644659.1 1769483 D 561275 CDS YP_002644660.1 224989973 7560559 1769719..1770384 1 NC_012207.1 transmembrane protein 1770384 7560559 JTY_1604 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002644660.1 1769719 D 561275 CDS YP_002644661.1 224989974 7560560 complement(1770549..1771889) 1 NC_012207.1 Differs from Rv1592c by 1aa, V322I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1771889 7560560 JTY_1605 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644661.1 1770549 R 561275 CDS YP_002644662.1 224989975 7560561 complement(1772146..1772856) 1 NC_012207.1 hypothetical protein 1772856 7560561 JTY_1606 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644662.1 1772146 R 561275 CDS YP_002644663.1 224989976 7560562 1772905..1773954 1 NC_012207.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 1773954 nadA 7560562 nadA Mycobacterium bovis BCG str. Tokyo 172 quinolinate synthetase YP_002644663.1 1772905 D 561275 CDS YP_002644664.1 224989977 7563585 1773954..1775537 1 NC_012207.1 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 1775537 nadB 7563585 nadB Mycobacterium bovis BCG str. Tokyo 172 L-aspartate oxidase YP_002644664.1 1773954 D 561275 CDS YP_002644665.1 224989978 7563586 1775537..1776394 1 NC_012207.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 1776394 nadC 7563586 nadC Mycobacterium bovis BCG str. Tokyo 172 nicotinate-nucleotide pyrophosphorylase YP_002644665.1 1775537 D 561275 CDS YP_002644666.1 224989979 7563587 1776443..1777201 1 NC_012207.1 Differs from Rv1597 by 2aa, D21G, M93L, and from Mb1623 by 1aa, M93L in BCG Pasteur and BCG Tokyo; hypothetical protein 1777201 7563587 JTY_1610 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644666.1 1776443 D 561275 CDS YP_002644667.1 224989980 7560563 complement(1777222..1777632) 1 NC_012207.1 hypothetical protein 1777632 7560563 JTY_1611 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644667.1 1777222 R 561275 CDS YP_002644668.1 224989981 7560564 1777732..1779048 1 NC_012207.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1779048 hisD 7560564 hisD Mycobacterium bovis BCG str. Tokyo 172 histidinol dehydrogenase YP_002644668.1 1777732 D 561275 CDS YP_002644669.1 224989982 7563312 1779045..1780187 1 NC_012207.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1780187 hisC1 7563312 hisC1 Mycobacterium bovis BCG str. Tokyo 172 histidinol-phosphate aminotransferase YP_002644669.1 1779045 D 561275 CDS YP_002644670.1 224989983 7563310 1780184..1780816 1 NC_012207.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 1780816 hisB 7563310 hisB Mycobacterium bovis BCG str. Tokyo 172 imidazoleglycerol-phosphate dehydratase YP_002644670.1 1780184 D 561275 CDS YP_002644671.1 224989984 7563309 1780813..1781433 1 NC_012207.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1781433 hisH 7563309 hisH Mycobacterium bovis BCG str. Tokyo 172 imidazole glycerol phosphate synthase subunit HisH YP_002644671.1 1780813 D 561275 CDS YP_002644672.1 224989985 7563316 1781443..1782180 1 NC_012207.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; phosphoribosyl isomerase A 1782180 hisA 7563316 hisA Mycobacterium bovis BCG str. Tokyo 172 phosphoribosyl isomerase A YP_002644672.1 1781443 D 561275 CDS YP_002644673.1 224989986 7563308 1782188..1783000 1 NC_012207.1 Differs from Rv1604 by 3aa, H93Y, Q124P, L251P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; inositol-monophosphatase 1783000 impA 7563308 impA Mycobacterium bovis BCG str. Tokyo 172 inositol-monophosphatase YP_002644673.1 1782188 D 561275 CDS YP_002644674.1 224989987 7562784 1783002..1783805 1 NC_012207.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 1783805 hisF 7562784 hisF Mycobacterium bovis BCG str. Tokyo 172 imidazole glycerol phosphate synthase subunit HisF YP_002644674.1 1783002 D 561275 CDS YP_002644675.1 224989988 7563314 1783802..1784149 1 NC_012207.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase 1784149 hisI 7563314 hisI Mycobacterium bovis BCG str. Tokyo 172 phosphoribosyl-AMP cyclohydrolase YP_002644675.1 1783802 D 561275 CDS YP_002644676.1 224989989 7563317 1784330..1785412 1 NC_012207.1 ionic transporter integral membrane protein 1785412 chaA 7563317 chaA Mycobacterium bovis BCG str. Tokyo 172 ionic transporter integral membrane protein YP_002644676.1 1784330 D 561275 CDS YP_002644677.1 224989990 7562102 complement(1785447..1785911) 1 NC_012207.1 peroxidoxin 1785911 bcpB 7562102 bcpB Mycobacterium bovis BCG str. Tokyo 172 peroxidoxin YP_002644677.1 1785447 R 561275 CDS YP_002644678.1 224989991 7562061 1786052..1787602 1 NC_012207.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1787602 trpE 7562061 trpE Mycobacterium bovis BCG str. Tokyo 172 anthranilate synthase component I YP_002644678.1 1786052 D 561275 CDS YP_002644679.1 224989992 7561632 1787592..1788299 1 NC_012207.1 hypothetical protein 1788299 7561632 JTY_1623 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644679.1 1787592 D 561275 CDS YP_002644680.1 224989993 7560565 1788389..1789207 1 NC_012207.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol phosphate synthase 1789207 trpC 7560565 trpC Mycobacterium bovis BCG str. Tokyo 172 indole-3-glycerol phosphate synthase YP_002644680.1 1788389 D 561275 CDS YP_002644681.1 224989994 7561630 1789276..1790508 1 NC_012207.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1790508 trpB 7561630 trpB Mycobacterium bovis BCG str. Tokyo 172 tryptophan synthase subunit beta YP_002644681.1 1789276 D 561275 CDS YP_002644682.1 224989995 7561629 1790508..1791320 1 NC_012207.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1791320 trpA 7561629 trpA Mycobacterium bovis BCG str. Tokyo 172 tryptophan synthase subunit alpha YP_002644682.1 1790508 D 561275 CDS YP_002644683.1 224989996 7561628 1791320..1792726 1 NC_012207.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1792726 lgt 7561628 lgt Mycobacterium bovis BCG str. Tokyo 172 prolipoprotein diacylglyceryl transferase YP_002644683.1 1791320 D 561275 CDS YP_002644684.1 224989997 7562824 1793402..1793842 1 NC_012207.1 hypothetical protein 1793842 7562824 JTY_1628 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644684.1 1793402 D 561275 CDS YP_002644685.1 224989998 7560566 1793832..1794230 1 NC_012207.1 hypothetical protein 1794230 7560566 JTY_1629 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644685.1 1793832 D 561275 CDS YP_002644686.1 224989999 7560567 1794338..1795756 1 NC_012207.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1795756 pykA 7560567 pykA Mycobacterium bovis BCG str. Tokyo 172 pyruvate kinase YP_002644686.1 1794338 D 561275 CDS YP_002644687.1 224990000 7560869 1795764..1796666 1 NC_012207.1 Differs from Rv1618 by 1aa, L121H in Mycobacterium tuberculosis CDC1331, Mycobacteoium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acyl-CoA thioesterase 1796666 tesB1 7560869 tesB1 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA thioesterase YP_002644687.1 1795764 D 561275 CDS YP_002644688.1 224990001 7561840 1796724..1798178 1 NC_012207.1 hypothetical protein 1798178 7561840 JTY_1632 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644688.1 1796724 D 561275 CDS YP_002644689.1 224990002 7560568 complement(1798112..1799842) 1 NC_012207.1 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein; ABC transporter 1799842 cydC 7560568 cydC Mycobacterium bovis BCG str. Tokyo 172 ABC transporter YP_002644689.1 1798112 R 561275 CDS YP_002644690.1 224990003 7563151 complement(1799839..1801422) 1 NC_012207.1 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein; ABC transporter 1801422 cydD 7563151 cydD Mycobacterium bovis BCG str. Tokyo 172 ABC transporter YP_002644690.1 1799839 R 561275 CDS YP_002644691.1 224990004 7563152 complement(1801509..1802549) 1 NC_012207.1 integral membrane cytochrome d ubiquinol oxidase subunit II 1802549 cydB 7563152 cydB Mycobacterium bovis BCG str. Tokyo 172 integral membrane cytochrome d ubiquinol oxidase subunit II YP_002644691.1 1801509 R 561275 CDS YP_002644692.1 224990005 7563150 complement(1802579..1804036) 1 NC_012207.1 integral membrane cytochrome d ubiquinol oxidase subunit I 1804036 cydA 7563150 cydA Mycobacterium bovis BCG str. Tokyo 172 integral membrane cytochrome d ubiquinol oxidase subunit I YP_002644692.1 1802579 R 561275 CDS YP_002644693.1 224990006 7563149 complement(1804147..1804734) 1 NC_012207.1 Differs from Rv1624c by 1aa, A178T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1804734 7563149 JTY_1637 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644693.1 1804147 R 561275 CDS YP_002644694.1 224990007 7560569 complement(1804763..1806019) 1 NC_012207.1 membrane-anchored adenylyl cyclase 1806019 cya 7560569 cya Mycobacterium bovis BCG str. Tokyo 172 membrane-anchored adenylyl cyclase YP_002644694.1 1804763 R 561275 CDS YP_002644695.1 224990008 7562820 1806329..1806946 1 NC_012207.1 two-component system transcriptional regulator 1806946 7562820 JTY_1639 Mycobacterium bovis BCG str. Tokyo 172 two-component system transcriptional regulator YP_002644695.1 1806329 D 561275 CDS YP_002644696.1 224990009 7560570 complement(1807014..1808222) 1 NC_012207.1 lipid-transfer protein 1808222 7560570 JTY_1640 Mycobacterium bovis BCG str. Tokyo 172 lipid-transfer protein YP_002644696.1 1807014 R 561275 CDS YP_002644697.1 224990010 7560571 complement(1808219..1808710) 1 NC_012207.1 Differs from Rv1628c and Mb1654c by 1aa, V93A in BCG Pasteur and BCG Tokyo; hypothetical protein 1808710 7560571 JTY_1641 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644697.1 1808219 R 561275 CDS YP_002644698.1 224990011 7560572 1808814..1811528 1 NC_012207.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 1811528 polA 7560572 polA Mycobacterium bovis BCG str. Tokyo 172 DNA polymerase I YP_002644698.1 1808814 D 561275 CDS YP_002644699.1 224990012 7562139 1811691..1813136 1 NC_012207.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1813136 rpsA 7562139 rpsA Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S1 YP_002644699.1 1811691 D 561275 CDS YP_002644700.1 224990013 7560728 1813162..1814385 1 NC_012207.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain; dephospho-CoA kinase/protein folding accessory domain-containing protein 1814385 coaE 7560728 coaE Mycobacterium bovis BCG str. Tokyo 172 dephospho-CoA kinase/protein folding accessory domain-containing protein YP_002644700.1 1813162 D 561275 CDS YP_002644701.1 224990014 7563102 complement(1814536..1814979) 1 NC_012207.1 hypothetical protein 1814979 7563102 JTY_1645 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644701.1 1814536 R 561275 CDS YP_002644702.1 224990015 7560573 1815224..1817320 1 NC_012207.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1817320 uvrB 7560573 uvrB Mycobacterium bovis BCG str. Tokyo 172 excinuclease ABC subunit B YP_002644702.1 1815224 D 561275 CDS YP_002644703.1 224990016 7561673 1817317..1818732 1 NC_012207.1 Differs from Rv1634 by 2aa, Q13E, R198G, and from Mb1660 by 1aa, Q13E in BCG Pasteur and BCG Tokyo; drug efflux membrane protein 1818732 7561673 JTY_1647 Mycobacterium bovis BCG str. Tokyo 172 drug efflux membrane protein YP_002644703.1 1817317 D 561275 CDS YP_002644704.1 224990017 7560574 complement(1818721..1820391) 1 NC_012207.1 hypothetical protein 1820391 7560574 JTY_1648 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644704.1 1818721 R 561275 CDS YP_002644705.1 224990018 7560575 1820600..1821040 1 NC_012207.1 hypothetical protein 1821040 TB15.3 7560575 TB15.3 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644705.1 1820600 D 561275 CDS YP_002644706.1 224990019 7561828 complement(1821047..1821841) 1 NC_012207.1 hypothetical protein 1821841 7561828 JTY_1650 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644706.1 1821047 R 561275 CDS YP_002644707.1 224990020 7560576 1821890..1824808 1 NC_012207.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 1824808 uvrA 7560576 uvrA Mycobacterium bovis BCG str. Tokyo 172 excinuclease ABC subunit A YP_002644707.1 1821890 D 561275 CDS YP_002644708.1 224990021 7561672 complement(1824865..1825122) 1 NC_012207.1 hypothetical protein 1825122 7561672 JTY_1652 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644708.1 1824865 R 561275 CDS YP_002644709.1 224990022 7560577 complement(1825138..1826607) 1 NC_012207.1 hypothetical protein 1826607 7560577 JTY_1653 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644709.1 1825138 R 561275 CDS YP_002644710.1 224990023 7560578 complement(1826666..1830184) 1 NC_012207.1 catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 1830184 lysS 7560578 lysS Mycobacterium bovis BCG str. Tokyo 172 lysyl-tRNA synthetase YP_002644710.1 1826666 R 561275 CDS YP_002644711.1 224990024 7560541 1830421..1831026 1 NC_012207.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1831026 infC 7560541 infC Mycobacterium bovis BCG str. Tokyo 172 translation initiation factor IF-3 YP_002644711.1 1830421 D 561275 CDS YP_002644712.1 224990025 7562787 1831076..1831270 1 NC_012207.1 50S ribosomal protein L35 1831270 rpmI 7562787 rpmI Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L35 YP_002644712.1 1831076 D 561275 CDS YP_002644713.1 224990026 7560722 1831332..1831721 1 NC_012207.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1831721 rplT 7560722 rplT Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L20 YP_002644713.1 1831332 D 561275 CDS YP_002644714.1 224990027 7561620 1831754..1832536 1 NC_012207.1 Differs from Rv1644 by 1aa, P232L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; 23S rRNA methyltransferase 1832536 tsnR 7561620 tsnR Mycobacterium bovis BCG str. Tokyo 172 23S rRNA methyltransferase YP_002644714.1 1831754 D 561275 CDS YP_002644715.1 224990028 7561643 complement(1832547..1833602) 1 NC_012207.1 hypothetical protein 1833602 7561643 JTY_1659 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644715.1 1832547 R 561275 CDS YP_002644716.1 224990029 7560579 1833912..1834844 1 NC_012207.1 PE family protein 1834844 PE17 7560579 PE17 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002644716.1 1833912 D 561275 CDS YP_002644717.1 224990030 7561717 1834922..1835872 1 NC_012207.1 Differs from Rv1647 by 1aa, P2A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 1835872 7561717 JTY_1661 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644717.1 1834922 D 561275 CDS YP_002644718.1 224990031 7560580 1835879..1836685 1 NC_012207.1 transmembrane protein 1836685 7560580 JTY_1662 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002644718.1 1835879 D 561275 CDS YP_002644719.1 224990032 7560581 1836881..1837906 1 NC_012207.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1837906 pheS 7560581 pheS Mycobacterium bovis BCG str. Tokyo 172 phenylalanyl-tRNA synthetase subunit alpha YP_002644719.1 1836881 D 561275 CDS YP_002644720.1 224990033 7562405 1837906..1840401 1 NC_012207.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1840401 pheT 7562405 pheT Mycobacterium bovis BCG str. Tokyo 172 phenylalanyl-tRNA synthetase subunit beta YP_002644720.1 1837906 D 561275 CDS YP_002644721.1 224990034 7562406 complement(1840495..1843551) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, an in-frame insertion of 21 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1018 aa versus 1011 aa). Differs from Rv1651c by insertion of 7aa at position 152 and by 1aa, V179A in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; PE-PGRS family protein 1843551 PE_PGRS30 7562406 PE_PGRS30 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644721.1 1840495 R 561275 CDS YP_002644722.1 224990035 7561772 1843745..1844803 1 NC_012207.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 1844803 argC 7561772 argC Mycobacterium bovis BCG str. Tokyo 172 N-acetyl-gamma-glutamyl-phosphate reductase YP_002644722.1 1843745 D 561275 CDS YP_002644723.1 224990036 7563984 1844800..1846014 1 NC_012207.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein 1846014 argJ 7563984 argJ Mycobacterium bovis BCG str. Tokyo 172 bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein YP_002644723.1 1844800 D 561275 CDS YP_002644724.1 224990037 7563989 1846011..1846895 1 NC_012207.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 1846895 argB 7563989 argB Mycobacterium bovis BCG str. Tokyo 172 acetylglutamate kinase YP_002644724.1 1846011 D 561275 CDS YP_002644725.1 224990038 7563983 1846892..1848094 1 NC_012207.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase 1848094 argD 7563983 argD Mycobacterium bovis BCG str. Tokyo 172 acetylornithine aminotransferase YP_002644725.1 1846892 D 561275 CDS YP_002644726.1 224990039 7563985 1848091..1849014 1 NC_012207.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 1849014 argF 7563985 argF Mycobacterium bovis BCG str. Tokyo 172 ornithine carbamoyltransferase YP_002644726.1 1848091 D 561275 CDS YP_002644727.1 224990040 7563986 1849011..1849523 1 NC_012207.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 1849523 argR 7563986 argR Mycobacterium bovis BCG str. Tokyo 172 arginine repressor ArgR YP_002644727.1 1849011 D 561275 CDS YP_002644728.1 224990041 7563990 1849532..1850728 1 NC_012207.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 1850728 argG 7563990 argG Mycobacterium bovis BCG str. Tokyo 172 argininosuccinate synthase YP_002644728.1 1849532 D 561275 CDS YP_002644729.1 224990042 7563987 1850808..1852220 1 NC_012207.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 1852220 argH 7563987 argH Mycobacterium bovis BCG str. Tokyo 172 argininosuccinate lyase YP_002644729.1 1850808 D 561275 CDS YP_002644730.1 224990043 7563988 1852329..1853390 1 NC_012207.1 chalcone synthase 1853390 pks10 7563988 pks10 Mycobacterium bovis BCG str. Tokyo 172 chalcone synthase YP_002644730.1 1852329 D 561275 CDS YP_002644731.1 224990044 7562441 1853473..1859853 1 NC_012207.1 Differs from Rv1661 by 2aa, W670R, P1176S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; polyketide synthase 1859853 pks7 7562441 pks7 Mycobacterium bovis BCG str. Tokyo 172 polyketide synthase YP_002644731.1 1853473 D 561275 CDS YP_002644732.1 224990045 7562124 1859873..1864678 1 NC_012207.1 Differs from Rv1662 by 6aa, Y78D, deletion of V692, V807A, G1260R, T1356A, C1468Y, and from Mb1690 by 1aa, deletion of V692 in BCG Pasteur and BCG Tokyo; polyketide synthase 1864678 pks8 7562124 pks8 Mycobacterium bovis BCG str. Tokyo 172 polyketide synthase YP_002644732.1 1859873 D 561275 CDS YP_002644733.1 224990046 7562125 1864678..1866186 1 NC_012207.1 polyketide synthase 1866186 pks17 7562125 pks17 Mycobacterium bovis BCG str. Tokyo 172 polyketide synthase YP_002644733.1 1864678 D 561275 CDS YP_002644734.1 224990047 7562118 1866192..1869245 1 NC_012207.1 Differs from Rv1664 by 2aa, T36A, P350A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; polyketide synthase 1869245 pks9 7562118 pks9 Mycobacterium bovis BCG str. Tokyo 172 polyketide synthase YP_002644734.1 1866192 D 561275 CDS YP_002644735.1 224990048 7562126 1869392..1870453 1 NC_012207.1 chalcone synthase 1870453 pks11 7562126 pks11 Mycobacterium bovis BCG str. Tokyo 172 chalcone synthase YP_002644735.1 1869392 D 561275 CDS YP_002644736.1 224990049 7562442 complement(1870436..1871728) 1 NC_012207.1 cytochrome P450 139 1871728 cyp139 7562442 cyp139 Mycobacterium bovis BCG str. Tokyo 172 cytochrome P450 139 YP_002644736.1 1870436 R 561275 CDS YP_002644737.1 224990050 7563165 complement(1871743..1873518) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1668c and Rv1667c exist as 2 genes with a small overlap between them. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 10 bp insertion (*-TCTTGCCGCG) leads to a single product; macrolide-transport ATP-binding protein ABC transporter 1873518 7563165 JTY_1681 Mycobacterium bovis BCG str. Tokyo 172 macrolide-transport ATP-binding protein ABC transporter YP_002644737.1 1871743 R 561275 CDS YP_002644738.1 224990051 7560582 1873901..1874263 1 NC_012207.1 hypothetical protein 1874263 7560582 JTY_1682 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644738.1 1873901 D 561275 CDS YP_002644739.1 224990052 7560583 1874296..1874643 1 NC_012207.1 hypothetical protein 1874643 7560583 JTY_1683 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644739.1 1874296 D 561275 CDS YP_002644740.1 224990053 7560584 1874651..1875043 1 NC_012207.1 hypothetical protein 1875043 7560584 JTY_1684 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644740.1 1874651 D 561275 CDS YP_002644741.1 224990054 7560585 complement(1875052..1876383) 1 NC_012207.1 integral membrane transport protein 1876383 7560585 JTY_1685 Mycobacterium bovis BCG str. Tokyo 172 integral membrane transport protein YP_002644741.1 1875052 R 561275 CDS YP_002644742.1 224990055 7560586 complement(1876476..1877408) 1 NC_012207.1 hypothetical protein 1877408 7560586 JTY_1686 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644742.1 1876476 R 561275 CDS YP_002644743.1 224990056 7560587 complement(1877436..1878092) 1 NC_012207.1 transcriptional regulatory protein 1878092 7560587 JTY_1687 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644743.1 1877436 R 561275 CDS YP_002644744.1 224990057 7560588 complement(1878417..1879151) 1 NC_012207.1 Differs from Rv1675c by 1aa, A59V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional regulatory protein 1879151 7560588 JTY_1688 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644744.1 1878417 R 561275 CDS YP_002644745.1 224990058 7560589 1879223..1879927 1 NC_012207.1 hypothetical protein 1879927 7560589 JTY_1689 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644745.1 1879223 D 561275 CDS YP_002644746.1 224990059 7560590 1879924..1880472 1 NC_012207.1 lipoprotein 1880472 dsbF 7560590 dsbF Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644746.1 1879924 D 561275 CDS YP_002644747.1 224990060 7561517 1880573..1881475 1 NC_012207.1 hypothetical protein 1881475 7561517 JTY_1691 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644747.1 1880573 D 561275 CDS YP_002644748.1 224990061 7560591 1881475..1882596 1 NC_012207.1 acyl-CoA dehydrogenase 1882596 fadE16 7560591 fadE16 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002644748.1 1881475 D 561275 CDS YP_002644749.1 224990062 7563364 1882605..1883429 1 NC_012207.1 Differs from Mb1707 by 1aa, A230G in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1883429 7563364 JTY_1693 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644749.1 1882605 D 561275 CDS YP_002644750.1 224990063 7560592 1883426..1884418 1 NC_012207.1 molybdopterin biosynthesis protein 1884418 moeX 7560592 moeX Mycobacterium bovis BCG str. Tokyo 172 molybdopterin biosynthesis protein YP_002644750.1 1883426 D 561275 CDS YP_002644751.1 224990064 7563544 1884579..1885496 1 NC_012207.1 coiled-coil structural protein 1885496 7563544 JTY_1695 Mycobacterium bovis BCG str. Tokyo 172 coiled-coil structural protein YP_002644751.1 1884579 D 561275 CDS YP_002644752.1 224990065 7560593 1885759..1888713 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1888713 7560593 JTY_1696 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002644752.1 1885759 D 561275 CDS YP_002644753.1 224990066 7560594 1888706..1888930 1 NC_012207.1 hypothetical protein 1888930 7560594 JTY_1697 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644753.1 1888706 D 561275 CDS YP_002644754.1 224990067 7560595 complement(1888896..1889519) 1 NC_012207.1 hypothetical protein 1889519 7560595 JTY_1698 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644754.1 1888896 R 561275 CDS YP_002644755.1 224990068 7560596 complement(1889521..1890201) 1 NC_012207.1 Differs from Rv1686c by 1aa, F20V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein ABC transporter 1890201 7560596 JTY_1699 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein ABC transporter YP_002644755.1 1889521 R 561275 CDS YP_002644756.1 224990069 7560597 complement(1890273..1891040) 1 NC_012207.1 ATP-binding protein ABC transporter 1891040 7560597 JTY_1700 Mycobacterium bovis BCG str. Tokyo 172 ATP-binding protein ABC transporter YP_002644756.1 1890273 R 561275 CDS YP_002644757.1 224990070 7560598 1891099..1891710 1 NC_012207.1 responsible for recognizing base lesions in the genome and initiating base excision DNA repair; 3-methyladenine DNA glycosylase 1891710 7560598 JTY_1701 Mycobacterium bovis BCG str. Tokyo 172 3-methyladenine DNA glycosylase YP_002644757.1 1891099 D 561275 CDS YP_002644758.1 224990071 7560599 1891722..1892996 1 NC_012207.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1892996 tyrS 7560599 tyrS Mycobacterium bovis BCG str. Tokyo 172 tyrosyl-tRNA synthetase YP_002644758.1 1891722 D 561275 CDS YP_002644759.1 224990072 7561647 1893647..1894030 1 NC_012207.1 In Mycobacterium bovis, a 2 bp insertion (*-AC) at the 5' end, leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG Pasteur and BCG Tokyo (139 aa versus 127 aa); lipoprotein 1894030 lprJ 7561647 lprJ Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644759.1 1893647 D 561275 CDS YP_002644760.1 224990073 7560528 1894069..1894821 1 NC_012207.1 hypothetical protein 1894821 7560528 JTY_1704 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644760.1 1894069 D 561275 CDS YP_002644761.1 224990074 7560600 1894818..1895879 1 NC_012207.1 phosphatase 1895879 7560600 JTY_1705 Mycobacterium bovis BCG str. Tokyo 172 phosphatase YP_002644761.1 1894818 D 561275 CDS YP_002644762.1 224990075 7560601 1895876..1896052 1 NC_012207.1 hypothetical protein 1896052 7560601 JTY_1706 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644762.1 1895876 D 561275 CDS YP_002644763.1 224990076 7560602 1896060..1896866 1 NC_012207.1 cytotoxin/hemolysin 1896866 tlyA 7560602 tlyA Mycobacterium bovis BCG str. Tokyo 172 cytotoxin/hemolysin YP_002644763.1 1896060 D 561275 CDS YP_002644764.1 224990077 7561861 1896866..1897789 1 NC_012207.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1897789 ppnK 7561861 ppnK Mycobacterium bovis BCG str. Tokyo 172 inorganic polyphosphate/ATP-NAD kinase YP_002644764.1 1896866 D 561275 CDS YP_002644765.1 224990078 7560810 1897803..1899566 1 NC_012207.1 DNA repair protein 1899566 recN 7560810 recN Mycobacterium bovis BCG str. Tokyo 172 DNA repair protein YP_002644765.1 1897803 D 561275 CDS YP_002644766.1 224990079 7561560 1899662..1900843 1 NC_012207.1 hypothetical protein 1900843 7561560 JTY_1710 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644766.1 1899662 D 561275 CDS YP_002644767.1 224990080 7560603 1900865..1901809 1 NC_012207.1 hypothetical protein 1901809 7560603 JTY_1711 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644767.1 1900865 D 561275 CDS YP_002644768.1 224990081 7560604 1901949..1903709 1 NC_012207.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1903709 pyrG 7560604 pyrG Mycobacterium bovis BCG str. Tokyo 172 CTP synthetase YP_002644768.1 1901949 D 561275 CDS YP_002644769.1 224990082 7560875 1903702..1904325 1 NC_012207.1 Differs from Mb1726 by 2aa, F43L, A202T in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1904325 7560875 JTY_1713 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644769.1 1903702 D 561275 CDS YP_002644770.1 224990083 7560605 1904322..1905257 1 NC_012207.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 1905257 xerD 7560605 xerD Mycobacterium bovis BCG str. Tokyo 172 site-specific tyrosine recombinase XerD YP_002644770.1 1904322 D 561275 CDS YP_002644771.1 224990084 7561697 complement(1905331..1906695) 1 NC_012207.1 hypothetical protein 1906695 7561697 JTY_1715 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644771.1 1905331 R 561275 CDS YP_002644772.1 224990085 7560606 complement(1907250..1907840) 1 NC_012207.1 Differs from Rv1703c and Mb1729c by 1aa, S48G in BCG Pasteur and BCG Tokyo; catechol-O-methyltransferase 1907840 7560606 JTY_1716 Mycobacterium bovis BCG str. Tokyo 172 catechol-O-methyltransferase YP_002644772.1 1907250 R 561275 CDS YP_002644773.1 224990086 7560607 complement(1907905..1909575) 1 NC_012207.1 Differs from Rv1704c by 2aa, L93R, S122G, and from Mb1730c by 1aa, S122G in BCG Pasteur and BCG Tokyo; D-serine/alanine/glycine transporter protein 1909575 cycA 7560607 cycA Mycobacterium bovis BCG str. Tokyo 172 D-serine/alanine/glycine transporter protein YP_002644773.1 1907905 R 561275 CDS YP_002644774.1 224990087 7563148 complement(1909616..1910773) 1 NC_012207.1 Differs from Rv1705c by 2aa, A2D, V313L, and from Mb1731c by 1aa, A2D in BCG Pasteur. Differs from Rv1705c by 1aa, V313L in BCG Tokyo.; PPE family protein 1910773 PPE22 7563148 PPE22 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644774.1 1909616 R 561275 CDS YP_002644775.1 224990088 7562159 complement(1910813..1911997) 1 NC_012207.1 PPE family protein 1911997 PPE23 7562159 PPE23 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644775.1 1910813 R 561275 CDS YP_002644776.1 224990089 7562160 complement(1912601..1912768) 1 NC_012207.1 hypothetical protein 1912768 7562160 JTY_1720 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644776.1 1912601 R 561275 CDS YP_002644777.1 224990090 7560608 1913001..1914461 1 NC_012207.1 Differs from Rv1707 by 1aa, Q438R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 1914461 7560608 JTY_1721 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002644777.1 1913001 D 561275 CDS YP_002644778.1 224990091 7560609 1914479..1915435 1 NC_012207.1 Differs from Rv1708 by 1a, a T56A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; initiation inhibitor protein 1915435 7560609 JTY_1722 Mycobacterium bovis BCG str. Tokyo 172 initiation inhibitor protein YP_002644778.1 1914479 D 561275 CDS YP_002644779.1 224990092 7560610 1915432..1916268 1 NC_012207.1 hypothetical protein 1916268 7560610 JTY_1723 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644779.1 1915432 D 561275 CDS YP_002644780.1 224990093 7560611 1916265..1916960 1 NC_012207.1 hypothetical protein 1916960 7560611 JTY_1724 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644780.1 1916265 D 561275 CDS YP_002644781.1 224990094 7560612 1916957..1917721 1 NC_012207.1 hypothetical protein 1917721 7560612 JTY_1725 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644781.1 1916957 D 561275 CDS YP_002644782.1 224990095 7560613 1917718..1918410 1 NC_012207.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1918410 cmk 7560613 cmk Mycobacterium bovis BCG str. Tokyo 172 cytidylate kinase YP_002644782.1 1917718 D 561275 CDS YP_002644783.1 224990096 7562116 1918407..1919798 1 NC_012207.1 synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1919798 engA 7562116 engA Mycobacterium bovis BCG str. Tokyo 172 GTP-binding protein EngA YP_002644783.1 1918407 D 561275 CDS YP_002644784.1 224990097 7562864 1919972..1920784 1 NC_012207.1 oxidoreductase 1920784 7562864 JTY_1728 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002644784.1 1919972 D 561275 CDS YP_002644785.1 224990098 7560614 1920778..1921692 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, Rv1715/fadB3 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) splits fadB3 into 2 parts, fadB3a and fadB3b; 3-hydroxybutyryl-CoA dehydrogenase 1921692 fadB3 7560614 fadB3 Mycobacterium bovis BCG str. Tokyo 172 3-hydroxybutyryl-CoA dehydrogenase YP_002644785.1 1920778 D 561275 CDS YP_002644786.1 224990099 7562912 1921695..1922525 1 NC_012207.1 Differs from Rv1716 by 2aa, G178S, A276V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 1922525 7562912 JTY_1730 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644786.1 1921695 D 561275 CDS YP_002644787.1 224990100 7560615 1922525..1922875 1 NC_012207.1 hypothetical protein 1922875 7560615 JTY_1731 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644787.1 1922525 D 561275 CDS YP_002644788.1 224990101 7560616 1922928..1923551 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, exists as a single gene. In Mycobacterium bovis AF2122/97, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base deletion (C-*) leads to a shorter product with a different COOH terminus; hypothetical protein 1923551 7560616 JTY_1732 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644788.1 1922928 D 561275 CDS YP_002644789.1 224990102 7560617 1923759..1924538 1 NC_012207.1 transcriptional regulatory protein 1924538 7560617 JTY_1733 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644789.1 1923759 D 561275 CDS YP_002644790.1 224990103 7560828 complement(1925148..1925537) 1 NC_012207.1 hypothetical protein 1925537 7560828 JTY_1734 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644790.1 1925148 R 561275 CDS YP_002644791.1 224990104 7560619 complement(1925534..1925761) 1 NC_012207.1 hypothetical protein 1925761 7560619 JTY_1735 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644791.1 1925534 R 561275 CDS YP_002644792.1 224990105 7560620 1925979..1927463 1 NC_012207.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; biotin carboxylase-like protein 1927463 7560620 JTY_1736 Mycobacterium bovis BCG str. Tokyo 172 biotin carboxylase-like protein YP_002644792.1 1925979 D 561275 CDS YP_002644793.1 224990106 7560621 1927460..1928707 1 NC_012207.1 hydrolase 1928707 7560621 JTY_1737 Mycobacterium bovis BCG str. Tokyo 172 hydrolase YP_002644793.1 1927460 D 561275 CDS YP_002644794.1 224990107 7560622 complement(1928750..1929169) 1 NC_012207.1 hypothetical protein 1929169 7560622 JTY_1738 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644794.1 1928750 R 561275 CDS YP_002644795.1 224990108 7560623 complement(1929159..1929869) 1 NC_012207.1 hypothetical protein 1929869 7560623 JTY_1739 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644795.1 1929159 R 561275 CDS YP_002644796.1 224990109 7560624 1929970..1931355 1 NC_012207.1 Differs from Rv1726 by 1aa, Y326H, and from Mb1755 by 1aa, A61P in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; oxidoreductase 1931355 7560624 JTY_1740 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002644796.1 1929970 D 561275 CDS YP_002644797.1 224990110 7560625 1931388..1931957 1 NC_012207.1 Differs from Rv1727 and Mb1756 by 1aa, D22E in BCG Pasteur and BCG Tokyo; hypothetical protein 1931957 7560625 JTY_1741 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644797.1 1931388 D 561275 CDS YP_002644798.1 224990111 7560626 complement(1931982..1932752) 1 NC_012207.1 hypothetical protein 1932752 7560626 JTY_1742 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644798.1 1931982 R 561275 CDS YP_002644799.1 224990112 7560627 complement(1932749..1933687) 1 NC_012207.1 hypothetical protein 1933687 7560627 JTY_1743 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644799.1 1932749 R 561275 CDS YP_002644800.1 224990113 7560628 complement(1933753..1935306) 1 NC_012207.1 penicillin-binding protein 1935306 7560628 JTY_1744 Mycobacterium bovis BCG str. Tokyo 172 penicillin-binding protein YP_002644800.1 1933753 R 561275 CDS YP_002644801.1 224990114 7560629 1935738..1937294 1 NC_012207.1 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinic semialdehyde dehydrogenase 1937294 gabD2 7560629 gabD2 Mycobacterium bovis BCG str. Tokyo 172 succinic semialdehyde dehydrogenase YP_002644801.1 1935738 D 561275 CDS YP_002644802.1 224990115 7561892 complement(1937304..1937852) 1 NC_012207.1 hypothetical protein 1937852 7561892 JTY_1746 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644802.1 1937304 R 561275 CDS YP_002644803.1 224990116 7563184 complement(1937916..1938548) 1 NC_012207.1 Differs from Rv1733c by 1aa, H68Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 1938548 7563184 JTY_1747 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002644803.1 1937916 R 561275 CDS YP_002644804.1 224990117 7563185 complement(1938835..1939077) 1 NC_012207.1 Differs from Mb1763c by 1aa, T79A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1939077 7563185 JTY_1748 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644804.1 1938835 R 561275 CDS YP_002644805.1 224990118 7563186 complement(1939352..1939849) 1 NC_012207.1 hypothetical protein 1939849 7563186 JTY_1749 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644805.1 1939352 R 561275 CDS YP_002644806.1 224990119 7563187 complement(1940289..1942247) 1 NC_012207.1 Diffesr from Rv1736c by 2aa, H53D, G77D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; nitrate reductase 1942247 narX 7563187 narX Mycobacterium bovis BCG str. Tokyo 172 nitrate reductase YP_002644806.1 1940289 R 561275 CDS YP_002644807.1 224990120 7562454 complement(1942244..1943431) 1 NC_012207.1 nitrate/nitrite transporter 1943431 narK2 7562454 narK2 Mycobacterium bovis BCG str. Tokyo 172 nitrate/nitrite transporter YP_002644807.1 1942244 R 561275 CDS YP_002644808.1 224990121 7562450 1943718..1944002 1 NC_012207.1 hypothetical protein 1944002 7562450 JTY_1752 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644808.1 1943718 D 561275 CDS YP_002644809.1 224990122 7563188 complement(1944016..1945698) 1 NC_012207.1 Differs from Rv1739c by 1aa, L134R in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; sulphate-transport transmembrane protein ABC transporter 1945698 7563188 JTY_1753 Mycobacterium bovis BCG str. Tokyo 172 sulphate-transport transmembrane protein ABC transporter YP_002644809.1 1944016 R 561275 CDS YP_002644810.1 224990123 7563189 1945766..1945978 1 NC_012207.1 hypothetical protein 1945978 7563189 JTY_1754 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644810.1 1945766 D 561275 CDS YP_002644811.1 224990124 7563190 1945978..1946226 1 NC_012207.1 Differs from Rv1741 by 1aa, T67K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1946226 7563190 JTY_1755 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644811.1 1945978 D 561275 CDS YP_002644812.1 224990125 7563191 1946307..1946972 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-C) leads to shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; hypothetical protein 1946972 7563191 JTY_1756 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644812.1 1946307 D 561275 CDS YP_002644813.1 224990126 7563192 1947066..1948766 1 NC_012207.1 Differs from Mb1772 by 1aa, V56D in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; transmembrane serine/threonine-protein kinase E 1948766 pknE 7563192 pknE Mycobacterium bovis BCG str. Tokyo 172 transmembrane serine/threonine-protein kinase E YP_002644813.1 1947066 D 561275 CDS YP_002644814.1 224990127 7562432 complement(1949051..1949452) 1 NC_012207.1 Differs from Rv1744c by 1aa, Q121R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1949452 7562432 JTY_1758 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644814.1 1949051 R 561275 CDS YP_002644815.1 224990128 7563193 complement(1949523..1950053) 1 NC_012207.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 1950053 idi 7563193 idi Mycobacterium bovis BCG str. Tokyo 172 isopentenyl-diphosphate delta-isomerase YP_002644815.1 1949523 R 561275 CDS YP_002644816.1 224990129 7563343 1950200..1951630 1 NC_012207.1 Differs from Rv1746 by 1aa, T325A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; anchored-membrane serine/threonine-protein kinase 1951630 pknF 7563343 pknF Mycobacterium bovis BCG str. Tokyo 172 anchored-membrane serine/threonine-protein kinase YP_002644816.1 1950200 D 561275 CDS YP_002644817.1 224990130 7562433 1951692..1954289 1 NC_012207.1 transmembrane ATP-binding protein ABC transporter 1954289 7562433 JTY_1761 Mycobacterium bovis BCG str. Tokyo 172 transmembrane ATP-binding protein ABC transporter YP_002644817.1 1951692 D 561275 CDS YP_002644818.1 224990131 7563194 1954662..1955393 1 NC_012207.1 hypothetical protein 1955393 7563194 JTY_1762 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644818.1 1954662 D 561275 CDS YP_002644819.1 224990132 7563195 complement(1955390..1955947) 1 NC_012207.1 integral membrane protein 1955947 7563195 JTY_1763 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002644819.1 1955390 R 561275 CDS YP_002644820.1 224990133 7563196 complement(1956031..1957629) 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1957629 fadD1 7563196 fadD1 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002644820.1 1956031 R 561275 CDS YP_002644821.1 224990134 7562915 1957683..1959065 1 NC_012207.1 Differs from Rv1751 by 2aa, T311M, L439V, and from Mb1780 by 1aa, T311M in BCG Pasteur and BCG Tokyo; hypothetical protein 1959065 7562915 JTY_1765 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644821.1 1957683 D 561275 CDS YP_002644822.1 224990135 7563197 1959192..1959641 1 NC_012207.1 hypothetical protein 1959641 7563197 JTY_1766 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644822.1 1959192 D 561275 CDS YP_002644823.1 224990136 7563198 complement(1959676..1962756) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, PPE24 differs in the 26 aa tandem repeat region, two copies less (in-frame deletion of 156 bp), and in the 25 aa repeat region, 2 and one more copies (in-frame insertion of 150bp and 75bp), respectively, compared to their homolog in Mycobacterium tuberculosis strain H37Rv; PPE family protein 1962756 PPE24 7563198 PPE24 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644823.1 1959676 R 561275 CDS YP_002644824.1 224990137 7562161 complement(1962960..1964651) 1 NC_012207.1 Differs from Rv1754c and Mb1783c by 1aa, S546N in BCG Pasteur and BCG Tokyo; hypothetical protein 1964651 7562161 JTY_1768 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644824.1 1962960 R 561275 CDS YP_002644825.1 224990138 7563199 complement(1964835..1966379) 1 NC_012207.1 Truncated by RvD2 deletion (6804bp) in Mycobacterium tuberculosis strain H37Rv; phospholipase C 4 1966379 plcD 7563199 plcD Mycobacterium bovis BCG str. Tokyo 172 phospholipase C 4 YP_002644825.1 1964835 R 561275 CDS YP_002644826.1 224990139 7562127 complement(1966508..1967692) 1 NC_012207.1 No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to the RvD2 region; hypothetical protein 1967692 7562127 JTY_1770 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644826.1 1966508 R 561275 CDS YP_002644827.1 224990140 7563200 1967842..1968981 1 NC_012207.1 No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to RvD2 region; sulfite oxidase 1968981 7563200 JTY_1771 Mycobacterium bovis BCG str. Tokyo 172 sulfite oxidase YP_002644827.1 1967842 D 561275 CDS YP_002644828.1 224990141 7563201 1969182..1972019 1 NC_012207.1 No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to RvD2 region; transmembrane transport protein 1972019 mmpL14 7563201 mmpL14 Mycobacterium bovis BCG str. Tokyo 172 transmembrane transport protein YP_002644828.1 1969182 D 561275 CDS YP_002644829.1 224990142 7564484 1972340..1972996 1 NC_012207.1 Belongs to the RvD2 region. In Mycobacterium tuberculosis strain H37Rv, Rv1758 is interrupted by IS6110 insertion element and the 5'-end is deleted; cutinase 1972996 cut1 7564484 cut1 Mycobacterium bovis BCG str. Tokyo 172 cutinase YP_002644829.1 1972340 D 561275 CDS YP_002644830.1 224990143 7563142 complement(1973263..1975674) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as a single gene. In Mycobacterium bovis BCG Pasteur and Tokyo, and Mycobacterium bovis, a single base deletion (C-*) splits wag22 into 2 parts, wag22a and wag22b. Differs from Mb1789c and Rv1759c by three deletions R129 replaced by AG, 5aa deletion at position 739 and 12aa deletion at position 777 making protein smaller (802 aa versus 820 aa) in BCG Pasteur. 5aa deletion at position 739 and 12aa deletion at position 777 making protein smaller (803 aa versus 820 aa) in BCG Tokyo.; PE-PGRS family protein 1975674 wag22b 7563142 wag22b Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644830.1 1973263 R 561275 CDS YP_002644831.1 224990144 7561684 complement(1975671..1975955) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as a single gene. In Mycobacterium bovis BCG Pasteur and Tokyo, and Mycobacterium bovis, a single base deletion (C-*) splits wag22 into 2 parts, wag22a and wag22b. Differs from Mb1789c and Rv1759c by three deletions R129 replaced by AG, 5aa deletion at position 739 and 12aa deletion at position 777 making protein smaller (802 aa versus 820 aa) in BCG Pasteur. 5aa deletion at position 739 and 12aa deletion at position 777 making protein smaller (803 aa versus 820 aa) in BCG Tokyo.; PE-PGRS family protein 1975955 wag22a 7561684 wag22a Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644831.1 1975671 R 561275 CDS YP_002644832.1 224990145 7561683 1976531..1978060 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Also differs from Rv1760 by 1aa, V219E; hypothetical protein 1978060 7561683 JTY_1776 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644832.1 1976531 D 561275 CDS YP_002644833.1 224990146 7563202 complement(1978048..1978431) 1 NC_012207.1 hypothetical protein 1978431 7563202 JTY_1777 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644833.1 1978048 R 561275 CDS YP_002644834.1 224990147 7563203 complement(1978431..1979219) 1 NC_012207.1 hypothetical protein 1979219 7563203 JTY_1778 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644834.1 1978431 R 561275 CDS YP_002644835.1 224990148 7563204 complement(1979359..1979826) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv this region is occupied by IS6110 which interrupts the gene and appears to have deleted sequences downstream. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, there is an 848bp sequence that has replaced a 121bp sequence corresponding to H37Rv positions 1997332-1997452; hypothetical protein 1979826 7563204 JTY_1779 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644835.1 1979359 R 561275 CDS YP_002644836.1 224990149 7563205 complement(1979924..1980076) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv this region is occupied by IS6110 which appears to have deleted sequences downstream. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, there is an 848bp sequence that has replaced a 121bp sequence corresponding to H37Rv positions 1997332-1997452; hypothetical protein 1980076 7563205 JTY_1780 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644836.1 1979924 R 561275 CDS YP_002644837.1 224990150 7563206 complement(1980237..1981493) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, deletion of 9068 bp (region of difference RD14), compared to Mycobacterium tuberculosis H37Rv (position: 1998226..2007293, 9068bp), Mycobacterium bovis AF2122/97 (position 1988666..1997751, 9086bp), and BCG Tokyo (position 1981204..1990289, 9086bp), removes genes Rv1765A-Rv1772 and merges truncated genes Rv1773c and Rv1765c in BCG Pasteur. Mycobacterium bovis (Mb1794c) and BCG Tokyo have a longer products to its homolg in Mycobacterium tuberculosis H37Rv (Rv1765c, 418 aa versus 365 aa).; hypothetical protein 1981493 7563206 JTY_1781 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644837.1 1980237 R 561275 CDS YP_002644838.1 224990151 7563207 complement(1982120..1982335) 1 NC_012207.1 Equivqlent to Mycobacterium bovis (Mb1975c) and Mycobavterium tuberculosis H37Rv (Rv1765A) in Mycobacterium bovis BCG Tokyo; hypothetical protein 1982335 7563207 JTY_1782 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644838.1 1982120 R 561275 CDS YP_002644839.1 224990152 7563208 1982715..1982984 1 NC_012207.1 Equivqlent to Mycobacterium bovis (Mb1975A) and Mycobavterium tuberculosis H37Rv (Rv1766) in Mycobacterium bovis BCG Tokyo; transposase 1982984 7563208 JTY_1783 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002644839.1 1982715 D 561275 CDS YP_002644840.1 224990153 7563209 1983052..1983411 1 NC_012207.1 Equivqlent to Mycobacterium bovis (Mb1796) and Mycobavterium tuberculosis H37Rv (Rv1767) in Mycobacterium bovis BCG Tokyo; hypothetical protein 1983411 7563209 JTY_1784 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644840.1 1983052 D 561275 CDS YP_002644841.1 224990154 7563210 1983592..1985466 1 NC_012207.1 In Mycobacterium bovis and Mycobacterium BCG Tokyo, a 18bp insertion, leads to a longer product compared to its homolog in Mycobacterium tuberculosis H37Rv (624 aa versus 618 aa).; PE-PGRS family protein 1985466 PE_PGRS31 7563210 PE_PGRS31 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644841.1 1983592 D 561275 CDS YP_002644842.1 224990155 7561773 1985622..1986866 1 NC_012207.1 Equivqlent to Mycobacterium bovis (Mb1798) and Mycobavterium tuberculosis H37Rv (Rv1769) in Mycobacterium bovis BCG Tokyo; hypothetical protein 1986866 7561773 JTY_1786 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644842.1 1985622 D 561275 CDS YP_002644843.1 224990156 7563211 1986874..1988160 1 NC_012207.1 Equivqlent to Mycobacterium bovis (Mb1799) and Mycobavterium tuberculosis H37Rv (Rv1770) in Mycobacterium bovis BCG Tokyo; hypothetical protein 1988160 7563211 JTY_1787 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644843.1 1986874 D 561275 CDS YP_002644844.1 224990157 7563212 1988157..1989443 1 NC_012207.1 Equivqlent to Mycobacterium bovis (Mb1800) and Mycobavterium tuberculosis H37Rv (Rv1771) in Mycobacterium bovis BCG Tokyo; oxidoreductase 1989443 7563212 JTY_1788 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002644844.1 1988157 D 561275 CDS YP_002644845.1 224990158 7563213 1989632..1989943 1 NC_012207.1 Equivqlent to Mycobacterium bovis (Mb1801) and Mycobavterium tuberculosis H37Rv (Rv1772) in Mycobacterium bovis BCG Tokyo; hypothetical protein 1989943 7563213 JTY_1789 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644845.1 1989632 D 561275 CDS YP_002644846.1 224990159 7563214 complement(1990016..1990762) 1 NC_012207.1 Equivqlent to Mycobacterium bovis (Mb1802c) and Mycobavterium tuberculosis H37Rv (Rv1773c) in Mycobacterium bovis BCG Tokyo; transcriptional regulatory protein 1990762 7563214 JTY_1790 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644846.1 1990016 R 561275 CDS YP_002644847.1 224990160 7563215 1990828..1992168 1 NC_012207.1 oxidoreductase 1992168 7563215 JTY_1791 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002644847.1 1990828 D 561275 CDS YP_002644848.1 224990161 7563216 1992168..1992986 1 NC_012207.1 hypothetical protein 1992986 7563216 JTY_1792 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644848.1 1992168 D 561275 CDS YP_002644849.1 224990162 7563217 complement(1992991..1993551) 1 NC_012207.1 transcriptional regulatory protein 1993551 7563217 JTY_1793 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644849.1 1992991 R 561275 CDS YP_002644850.1 224990163 7563218 1993652..1994956 1 NC_012207.1 Differs from Rv1777 by 1aa Q325H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cytochrome p450 144 1994956 cyp144 7563218 cyp144 Mycobacterium bovis BCG str. Tokyo 172 cytochrome p450 144 YP_002644850.1 1993652 D 561275 CDS YP_002644851.1 224990164 7563170 complement(1995077..1995526) 1 NC_012207.1 Differs from Mb1807c by 1aa T32R in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1995526 7563170 JTY_1795 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644851.1 1995077 R 561275 CDS YP_002644852.1 224990165 7563219 complement(1995682..1997475) 1 NC_012207.1 hypothetical protein 1997475 7563219 JTY_1796 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644852.1 1995682 R 561275 CDS YP_002644853.1 224990166 7563220 1997695..1998258 1 NC_012207.1 hypothetical protein 1998258 7563220 JTY_1797 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644853.1 1997695 D 561275 CDS YP_002644854.1 224990167 7563221 complement(1998298..2000472) 1 NC_012207.1 Differs from Rv1781c and Mb1810c by 1aa, T12A in BCG Pasteur and BCG Tokyo; 4-alpha-glucanotransferase 2000472 malQ 7563221 malQ Mycobacterium bovis BCG str. Tokyo 172 4-alpha-glucanotransferase YP_002644854.1 1998298 R 561275 CDS YP_002644855.1 224990168 7560547 2000736..2002256 1 NC_012207.1 Differs from Rv1782 by 1aa H41R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2002256 7560547 JTY_1799 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644855.1 2000736 D 561275 CDS YP_002644856.1 224990169 7563222 2002253..2006428 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1783 and Rv1784 exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base transversion (a-t) leads to a single product. Differs from Rv1783 and Mb1812 by 1aa, V692A in BCG Pasteur, identical to Rv1784 in BCG Pasteur and Tokyo.; hypothetical protein 2006428 7563222 JTY_1800 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644856.1 2002253 D 561275 CDS YP_002644857.1 224990170 7563223 complement(2006443..2007624) 1 NC_012207.1 cytochrome P450 143 2007624 cyp143 7563223 cyp143 Mycobacterium bovis BCG str. Tokyo 172 cytochrome P450 143 YP_002644857.1 2006443 R 561275 CDS YP_002644858.1 224990171 7563169 2007824..2008027 1 NC_012207.1 ferredoxin 2008027 7563169 JTY_1802 Mycobacterium bovis BCG str. Tokyo 172 ferredoxin YP_002644858.1 2007824 D 561275 CDS YP_002644859.1 224990172 7563224 2008297..2009391 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 8 bp to 5 bp substitution (AGCCCGGT-CCGGG), leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (364 aa versus 365 aa). Identical to Mb1815; PPE family protein 2009391 PPE25 7563224 PPE25 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644859.1 2008297 D 561275 CDS YP_002644860.1 224990173 7562162 2009470..2009769 1 NC_012207.1 PE family protein 2009769 PE18 7562162 PE18 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002644860.1 2009470 D 561275 CDS YP_002644861.1 224990174 7561718 2009783..2010964 1 NC_012207.1 Differs from Mb1817 by 1aa, S274A, identical to Rv1789 in BCG Pasteur and BCG Tokyo; PPE family protein 2010964 PPE26 7561718 PPE26 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644861.1 2009783 D 561275 CDS YP_002644862.1 224990175 7562163 2011418..2012470 1 NC_012207.1 Identical to Rv1790 differs from Mb1818 by 1aa, P190S in BCG Pasteur and BCG Tokyo; PPE family protein 2012470 PPE27 7562163 PPE27 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644862.1 2011418 D 561275 CDS YP_002644863.1 224990176 7562164 2012897..2013196 1 NC_012207.1 PE family protein 2013196 PE19 7562164 PE19 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002644863.1 2012897 D 561275 CDS YP_002644864.1 224990177 7561719 2013340..2013636 1 NC_012207.1 Differs from Rv1792 by 1aa Q48M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2013636 esxM 7561719 esxM Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644864.1 2013340 D 561275 CDS YP_002644865.1 224990178 7562884 2013687..2013971 1 NC_012207.1 EsaT-6 like protein 5 2013971 esxN 7562884 esxN Mycobacterium bovis BCG str. Tokyo 172 EsaT-6 like protein 5 YP_002644865.1 2013687 D 561275 CDS YP_002644866.1 224990179 7562885 2014059..2014961 1 NC_012207.1 hypothetical protein 2014961 7562885 JTY_1810 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644866.1 2014059 D 561275 CDS YP_002644867.1 224990180 7563225 2015233..2016744 1 NC_012207.1 Differs from Mb1823 and Rv1795 by 1aa, T256A and D261G, respectively, in BCG Pasteur and BCG Tokyo; hypothetical protein 2016744 7563225 JTY_1811 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644867.1 2015233 D 561275 CDS YP_002644868.1 224990181 7563226 2016722..2018479 1 NC_012207.1 hypothetical pro-rich protease 2018479 7563226 JTY_1812 Mycobacterium bovis BCG str. Tokyo 172 hypothetical pro-rich protease YP_002644868.1 2016722 D 561275 CDS YP_002644869.1 224990182 7563227 2018476..2019696 1 NC_012207.1 hypothetical protein 2019696 7563227 JTY_1813 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644869.1 2018476 D 561275 CDS YP_002644870.1 224990183 7563228 2019693..2021525 1 NC_012207.1 hypothetical protein 2021525 7563228 JTY_1814 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644870.1 2019693 D 561275 CDS YP_002644871.1 224990184 7563229 2022152..2022343 1 NC_012207.1 lipoprotein 2022343 lppT 7563229 lppT Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644871.1 2022152 D 561275 CDS YP_002644872.1 224990185 7560486 2022446..2024413 1 NC_012207.1 Differs from Rv1800 by 3aa, W144C, V253F, V432I, and from Mb1828 by 1aa, V432I in BCG Pasteur and BCG Tokyo; PPE family protein 2024413 PPE28 7560486 PPE28 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644872.1 2022446 D 561275 CDS YP_002644873.1 224990186 7562165 2024994..2026265 1 NC_012207.1 PPE family protein 2026265 PPE29 7562165 PPE29 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644873.1 2024994 D 561275 CDS YP_002644874.1 224990187 7562166 2026377..2027768 1 NC_012207.1 PPE family protein 2027768 PPE30 7562166 PPE30 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644874.1 2026377 D 561275 CDS YP_002644875.1 224990188 7562168 complement(2027916..2029538) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS32 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base transition (C-T) splits PE_PGRS32 into 2 parts, PE_PGRS32a and PE_PGRS32b; PE-PGRS family protein 2029538 PE_PGRS32b 7562168 PE_PGRS32b Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644875.1 2027916 R 561275 CDS YP_002644876.1 224990189 7561775 complement(2029572..2029835) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS32 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base transition (C-T) splits PE_PGRS32 into 2 parts, PE_PGRS32a and PE_PGRS32b; PE-PGRS family protein 2029835 PE_PGRS32a 7561775 PE_PGRS32a Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644876.1 2029572 R 561275 CDS YP_002644877.1 224990190 7561774 complement(2030016..2030342) 1 NC_012207.1 hypothetical protein 2030342 7561774 JTY_1821 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644877.1 2030016 R 561275 CDS YP_002644878.1 224990191 7563230 complement(2030680..2031027) 1 NC_012207.1 hypothetical protein 2031027 7563230 JTY_1822 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644878.1 2030680 R 561275 CDS YP_002644879.1 224990192 7563231 2031065..2031364 1 NC_012207.1 PE family protein 2031364 PE20 7563231 PE20 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002644879.1 2031065 D 561275 CDS YP_002644880.1 224990193 7561721 2031379..2032590 1 NC_012207.1 Differs from Rv1807 by 2aa, S223F, L234V. Identicalto Mb1836 in BCG Pasteur and BCG Tokyo; PPE family protein 2032590 PPE31 7561721 PPE31 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644880.1 2031379 D 561275 CDS YP_002644881.1 224990194 7562169 2032914..2034143 1 NC_012207.1 Differs from Rv1808 by 1aa, A301G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PPE family protein 2034143 PPE32 7562169 PPE32 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644881.1 2032914 D 561275 CDS YP_002644882.1 224990195 7562170 2034275..2034838 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PPE33 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base transition (C-T) splits PPE33 into 2 parts, PPE33a and PPE33b; PPE Family protein 2034838 PPE33a 7562170 PPE33a Mycobacterium bovis BCG str. Tokyo 172 PPE Family protein YP_002644882.1 2034275 D 561275 CDS YP_002644883.1 224990196 7562172 2035926..2036282 1 NC_012207.1 hypothetical protein 2036282 7562172 JTY_1828 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644883.1 2035926 D 561275 CDS YP_002644884.1 224990197 7563232 2036436..2037140 1 NC_012207.1 MgtC; Mg2+ transport P-type ATPase C 2037140 7563232 JTY_1829 Mycobacterium bovis BCG str. Tokyo 172 Mg2+ transport P-type ATPase C YP_002644884.1 2036436 D 561275 CDS YP_002644885.1 224990198 7563233 complement(2037150..2038352) 1 NC_012207.1 Differs from Rv1812c by 1aa, P30L in Mycobacteium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; dehydrogenase 2038352 7563233 JTY_1830 Mycobacterium bovis BCG str. Tokyo 172 dehydrogenase YP_002644885.1 2037150 R 561275 CDS YP_002644886.1 224990199 7563234 complement(2038674..2039105) 1 NC_012207.1 hypothetical protein 2039105 7563234 JTY_1831 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644886.1 2038674 R 561275 CDS YP_002644887.1 224990200 7563235 2039514..2040416 1 NC_012207.1 membrane-bound C-5 sterol desaturase 2040416 erg3 7563235 erg3 Mycobacterium bovis BCG str. Tokyo 172 membrane-bound C-5 sterol desaturase YP_002644887.1 2039514 D 561275 CDS YP_002644888.1 224990201 7562873 2040521..2041186 1 NC_012207.1 Differs from Rv1815 by 1aa, F83I in Mycobacteium tuberculosis CDC1551, Mycobacteium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 2041186 7562873 JTY_1833 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644888.1 2040521 D 561275 CDS YP_002644889.1 224990202 7563236 2041249..2041953 1 NC_012207.1 transcriptional regulatory protein 2041953 7563236 JTY_1834 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644889.1 2041249 D 561275 CDS YP_002644891.1 224990204 7563238 2042588..2044051 1 NC_012207.1 hypothetical protein 2044051 7563238 JTY_1836 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644891.1 2042588 D 561275 CDS YP_002644892.1 224990205 7563239 complement(2044171..2045676) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 9 bp insertion (*-GCCGCCGGC), leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (501 aa versus 498 aa). Differs from Rv1818c by 4aa, S233G, and deletion of 3aa near C-terminus. Identical to Mb1849c; PE-PGRS family protein 2045676 PE_PGRS33 7563239 PE_PGRS33 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644892.1 2044171 R 561275 CDS YP_002644893.1 224990206 7561776 complement(2045811..2047730) 1 NC_012207.1 Differs from Rv1819c by 1aa, V603I in BCG Pasteur and BCG Tokyo; drugs-transport transmembrane ATP-binding protein ABC transporter 2047730 7561776 JTY_1838 Mycobacterium bovis BCG str. Tokyo 172 drugs-transport transmembrane ATP-binding protein ABC transporter YP_002644893.1 2045811 R 561275 CDS YP_002644894.1 224990207 7563240 2047801..2049444 1 NC_012207.1 hypothetical protein 2049444 ilvG 7563240 ilvG Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644894.1 2047801 D 561275 CDS YP_002644895.1 224990208 7562781 2049459..2051885 1 NC_012207.1 SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 2051885 secA2 7562781 secA2 Mycobacterium bovis BCG str. Tokyo 172 preprotein translocase subunit SecA YP_002644895.1 2049459 D 561275 CDS YP_002644896.1 224990209 7560771 2052082..2052711 1 NC_012207.1 CDP-diacylglycerol--glycerol-3- phosphate 3-phosphatidyltransferase 2052711 pgsA2 7560771 pgsA2 Mycobacterium bovis BCG str. Tokyo 172 CDP-diacylglycerol--glycerol-3- phosphate 3-phosphatidyltransferase YP_002644896.1 2052082 D 561275 CDS YP_002644897.1 224990210 7562402 2052704..2053627 1 NC_012207.1 hypothetical protein 2053627 7562402 JTY_1842 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644897.1 2052704 D 561275 CDS YP_002644898.1 224990211 7563241 2053656..2054021 1 NC_012207.1 hypothetical protein 2054021 7563241 JTY_1843 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644898.1 2053656 D 561275 CDS YP_002644899.1 224990212 7563242 2054038..2054916 1 NC_012207.1 hypothetical protein 2054916 7563242 JTY_1844 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644899.1 2054038 D 561275 CDS YP_002644900.1 224990213 7563243 2054954..2055358 1 NC_012207.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 2055358 gcvH 7563243 gcvH Mycobacterium bovis BCG str. Tokyo 172 glycine cleavage system protein H YP_002644900.1 2054954 D 561275 CDS YP_002644901.1 224990214 7561910 2055598..2056086 1 NC_012207.1 hypothetical protein 2056086 cfp17 7561910 cfp17 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644901.1 2055598 D 561275 CDS YP_002644902.1 224990215 7562097 2056083..2056826 1 NC_012207.1 hypothetical protein 2056826 7562097 JTY_1847 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644902.1 2056083 D 561275 CDS YP_002644903.1 224990216 7563244 2056945..2057439 1 NC_012207.1 Differs from Mb1860 by 1aa R93C in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 2057439 7563244 JTY_1848 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644903.1 2056945 D 561275 CDS YP_002644904.1 224990217 7563245 2057787..2058464 1 NC_012207.1 hypothetical protein 2058464 7563245 JTY_1849 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644904.1 2057787 D 561275 CDS YP_002644905.1 224990218 7563246 2058517..2058774 1 NC_012207.1 hypothetical protein 2058774 7563246 JTY_1850 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644905.1 2058517 D 561275 CDS YP_002644906.1 224990219 7563247 2058823..2061648 1 NC_012207.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 2061648 gcvB 7563247 gcvB Mycobacterium bovis BCG str. Tokyo 172 glycine dehydrogenase YP_002644906.1 2058823 D 561275 CDS YP_002644907.1 224990220 7561909 complement(2061875..2062735) 1 NC_012207.1 haloalkane dehalogenase 2062735 7561909 JTY_1852 Mycobacterium bovis BCG str. Tokyo 172 haloalkane dehalogenase YP_002644907.1 2061875 R 561275 CDS YP_002644908.1 224990221 7563248 2062776..2063642 1 NC_012207.1 Differs from Mb1865 by 1aa, V272A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrolase 2063642 7563248 JTY_1853 Mycobacterium bovis BCG str. Tokyo 172 hydrolase YP_002644908.1 2062776 D 561275 CDS YP_002644909.1 224990222 7563249 complement(2063647..2065533) 1 NC_012207.1 hypothetical protein 2065533 7563249 JTY_1854 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644909.1 2063647 R 561275 CDS YP_002644910.1 224990223 7563250 complement(2065549..2067582) 1 NC_012207.1 Differs from Rv1836c by 2aa, C137R, H591R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2067582 7563250 JTY_1855 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644910.1 2065549 R 561275 CDS YP_002644911.1 224990224 7563251 complement(2067702..2069927) 1 NC_012207.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 2069927 glcB 7563251 glcB Mycobacterium bovis BCG str. Tokyo 172 malate synthase G YP_002644911.1 2067702 R 561275 CDS YP_002644912.1 224990225 7561918 complement(2070203..2070598) 1 NC_012207.1 hypothetical protein 2070598 7561918 JTY_1857 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644912.1 2070203 R 561275 CDS YP_002644913.1 224990226 7563252 complement(2070595..2070858) 1 NC_012207.1 hypothetical protein 2070858 7563252 JTY_1858 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644913.1 2070595 R 561275 CDS YP_002644914.1 224990227 7561778 complement(2071645..2072463) 1 NC_012207.1 In Mycobacterium bovis, an in-frame deletion of 147bp leads to a shorter protein compared to its homolog in Mycobacterium tuberculosis strain H37Rv (466 aa versus 518 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a deletion of 1bp, splits PPE34 into 2 parts, PPE34a and PPE34b; PE-PGRS family protein 2072463 PE_PGRS34a 7561778 PE_PGRS34a Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002644914.1 2071645 R 561275 CDS YP_002644915.1 224990228 7561777 complement(2072626..2073675) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 12 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (349 aa versus 345 aa); hypothetical protein 2073675 7561777 JTY_1861 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644915.1 2072626 R 561275 CDS YP_002644916.1 224990229 7563254 complement(2073675..2075042) 1 NC_012207.1 Differs from Rv1842c by 1aa, S437L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2075042 7563254 JTY_1862 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644916.1 2073675 R 561275 CDS YP_002644917.1 224990230 7563255 complement(2075216..2076655) 1 NC_012207.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 2076655 guaB1 7563255 guaB1 Mycobacterium bovis BCG str. Tokyo 172 inosine 5-monophosphate dehydrogenase YP_002644917.1 2075216 R 561275 CDS YP_002644918.1 224990231 7563288 complement(2076021..2078078) 1 NC_012207.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2078078 gnd1 7563288 gnd1 Mycobacterium bovis BCG str. Tokyo 172 6-phosphogluconate dehydrogenase YP_002644918.1 2076021 R 561275 CDS YP_002644919.1 224990232 7563272 complement(2078168..2079118) 1 NC_012207.1 Differs from Rv1845c and Mb1876c by 1aa, A222V in BCG Pasteur and BCG Tokyo; hypothetical protein 2079118 7563272 JTY_1865 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644919.1 2078168 R 561275 CDS YP_002644920.1 224990233 7563256 complement(2079133..2079549) 1 NC_012207.1 Differs from Rv1846c by 1aa, Y92D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional regulatory protein 2079549 7563256 JTY_1866 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002644920.1 2079133 R 561275 CDS YP_002644921.1 224990234 7563257 2079827..2080249 1 NC_012207.1 Differs from Rv1847 by 1aa, L90V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2080249 7563257 JTY_1867 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644921.1 2079827 D 561275 CDS YP_002644922.1 224990235 7563258 2080298..2080600 1 NC_012207.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 2080600 ureA 7563258 ureA Mycobacterium bovis BCG str. Tokyo 172 urease subunit gamma YP_002644922.1 2080298 D 561275 CDS YP_002644923.1 224990236 7561662 2080597..2080911 1 NC_012207.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); urease subunit beta 2080911 ureB 7561662 ureB Mycobacterium bovis BCG str. Tokyo 172 urease subunit beta YP_002644923.1 2080597 D 561275 CDS YP_002644924.1 224990237 7561663 2080911..2082644 1 NC_012207.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 2082644 ureC 7561663 ureC Mycobacterium bovis BCG str. Tokyo 172 urease subunit alpha YP_002644924.1 2080911 D 561275 CDS YP_002644925.1 224990238 7561664 2082644..2083279 1 NC_012207.1 Differs from Rv1851 by 1aa, L34V in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; urease accessory protein 2083279 ureF 7561664 ureF Mycobacterium bovis BCG str. Tokyo 172 urease accessory protein YP_002644925.1 2082644 D 561275 CDS YP_002644926.1 224990239 7561666 2083290..2083964 1 NC_012207.1 urease accessory protein 2083964 ureG 7561666 ureG Mycobacterium bovis BCG str. Tokyo 172 urease accessory protein YP_002644926.1 2083290 D 561275 CDS YP_002644927.1 224990240 7561667 2083972..2084598 1 NC_012207.1 urease accessory protein 2084598 ureD 7561667 ureD Mycobacterium bovis BCG str. Tokyo 172 urease accessory protein YP_002644927.1 2083972 D 561275 CDS YP_002644928.1 224990241 7561665 complement(2084601..2085992) 1 NC_012207.1 Differs from Rv1854c by 1aa, R313G, and Mb1885c by 2aa, R284W, R313G in BCG Pasteur and BCG Tokyo; NADH dehydrogenase 2085992 ndh 7561665 ndh Mycobacterium bovis BCG str. Tokyo 172 NADH dehydrogenase YP_002644928.1 2084601 R 561275 CDS YP_002644929.1 224990242 7562456 complement(2086133..2087056) 1 NC_012207.1 oxidoreductase 2087056 7562456 JTY_1875 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002644929.1 2086133 R 561275 CDS YP_002644930.1 224990243 7563259 complement(2087095..2087772) 1 NC_012207.1 Differs from Rv1856c by 1aa, H185R in BCG Pasteur and BCG Tokyo; short chain dehydrogenase 2087772 7563259 JTY_1876 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002644930.1 2087095 R 561275 CDS YP_002644931.1 224990244 7563260 2087934..2088719 1 NC_012207.1 molybdate-binding lipoprotein 2088719 modA 7563260 modA Mycobacterium bovis BCG str. Tokyo 172 molybdate-binding lipoprotein YP_002644931.1 2087934 D 561275 CDS YP_002644932.1 224990245 7563536 2088722..2089516 1 NC_012207.1 molbdenum-transport integral membrane protein ABC transporter 2089516 modB 7563536 modB Mycobacterium bovis BCG str. Tokyo 172 molbdenum-transport integral membrane protein ABC transporter YP_002644932.1 2088722 D 561275 CDS YP_002644933.1 224990246 7563537 2089523..2090632 1 NC_012207.1 Differs from Rv1859 by 1aa, M313T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; molybdenum-transport ATP-binding protein ABC transporter 2090632 modC 7563537 modC Mycobacterium bovis BCG str. Tokyo 172 molybdenum-transport ATP-binding protein ABC transporter YP_002644933.1 2089523 D 561275 CDS YP_002644934.1 224990247 7563538 2090685..2091662 1 NC_012207.1 Differs from Rv1860 by 1aa, L136F in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2091662 apa 7563538 apa Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644934.1 2090685 D 561275 CDS YP_002644935.1 224990248 7563980 2092114..2092419 1 NC_012207.1 transmembrane protein 2092419 7563980 JTY_1881 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002644935.1 2092114 D 561275 CDS YP_002644936.1 224990249 7563261 2092494..2093534 1 NC_012207.1 alcohol dehydrogenase 2093534 adhA 7563261 adhA Mycobacterium bovis BCG str. Tokyo 172 alcohol dehydrogenase YP_002644936.1 2092494 D 561275 CDS YP_002644937.1 224990250 7563941 complement(2093541..2094311) 1 NC_012207.1 hypothetical protein 2094311 7563941 JTY_1883 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644937.1 2093541 R 561275 CDS YP_002644938.1 224990251 7563262 complement(2094304..2095059) 1 NC_012207.1 hypothetical protein 2095059 7563262 JTY_1884 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644938.1 2094304 R 561275 CDS YP_002644939.1 224990252 7563263 complement(2095056..2095916) 1 NC_012207.1 short chain dehydrogenase 2095916 7563263 JTY_1885 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002644939.1 2095056 R 561275 CDS YP_002644940.1 224990253 7563264 2096090..2098426 1 NC_012207.1 Differs from Rv1866 by 1aa, Q17E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2098426 7563264 JTY_1886 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644940.1 2096090 D 561275 CDS YP_002644941.1 224990254 7563265 2098714..2100198 1 NC_012207.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 2100198 7563265 JTY_1887 Mycobacterium bovis BCG str. Tokyo 172 acetyl-CoA acetyltransferase YP_002644941.1 2098714 D 561275 CDS YP_002644942.1 224990255 7560630 2100297..2102396 1 NC_012207.1 Differs from Rv1868 and Mb1899 by 1aa, G621D in BCG Pasteur and BCG Tokyo; hypothetical protein 2102396 7560630 JTY_1888 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644942.1 2100297 D 561275 CDS YP_002644943.1 224990256 7560631 complement(2102410..2103645) 1 NC_012207.1 Differs from Mb1900c and Rv1869c by 1aa, P4S in BCG Pasteur and BCG Tokyo; reductase 2103645 7560631 JTY_1889 Mycobacterium bovis BCG str. Tokyo 172 reductase YP_002644943.1 2102410 R 561275 CDS YP_002644944.1 224990257 7560632 complement(2103712..2104380) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transversion (T-A) and a single base transition (C-T) lead to a slightly longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (222 aa versus 211 aa); hypothetical protein 2104380 7560632 JTY_1890 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644944.1 2103712 R 561275 CDS YP_002644945.1 224990258 7560633 complement(2104445..2104834) 1 NC_012207.1 hypothetical protein 2104834 7560633 JTY_1891 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644945.1 2104445 R 561275 CDS YP_002644946.1 224990259 7560634 complement(2104857..2106101) 1 NC_012207.1 Differs from Rv1872c by 2aa, A59G, A176V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cytochrome; L-lactate dehydrogenase 2106101 lldD2 7560634 lldD2 Mycobacterium bovis BCG str. Tokyo 172 L-lactate dehydrogenase YP_002644946.1 2104857 R 561275 CDS YP_002644947.1 224990260 7562851 2106124..2106561 1 NC_012207.1 Differs from Mb1904 by 1aa, D102N in BCG Pasteur and BCG Tokyo; hypothetical protein 2106561 7562851 JTY_1893 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644947.1 2106124 D 561275 CDS YP_002644948.1 224990261 7560635 2106634..2107320 1 NC_012207.1 hypothetical protein 2107320 7560635 JTY_1894 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644948.1 2106634 D 561275 CDS YP_002644949.1 224990262 7560636 2107331..2107774 1 NC_012207.1 hypothetical protein 2107774 7560636 JTY_1895 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644949.1 2107331 D 561275 CDS YP_002644950.1 224990263 7560637 2108290..2108769 1 NC_012207.1 bacterioferritin 2108769 bfrA 7560637 bfrA Mycobacterium bovis BCG str. Tokyo 172 bacterioferritin YP_002644950.1 2108290 D 561275 CDS YP_002644951.1 224990264 7562063 2108854..2110389 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-C), splits Rv1877 into 2 parts; integral membrane protein 2110389 7562063 JTY_1897 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002644951.1 2108854 D 561275 CDS YP_002644952.1 224990265 7560638 2109704..2110918 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-C), splits Rv1877 into 2 parts; integral membrane protein 2110918 7560638 JTY_1898 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002644952.1 2109704 D 561275 CDS YP_002644953.1 224990266 7560639 2110973..2112325 1 NC_012207.1 Identical to Rv1878, differs from Mb1910 by 1aa, A275T in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; glutamine synthetase 2112325 glnA3 7560639 glnA3 Mycobacterium bovis BCG str. Tokyo 172 glutamine synthetase YP_002644953.1 2110973 D 561275 CDS YP_002644954.1 224990267 7561928 2112328..2113464 1 NC_012207.1 hypothetical protein 2113464 7561928 JTY_1900 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644954.1 2112328 D 561275 CDS YP_002644955.1 224990268 7560640 complement(2113492..2114808) 1 NC_012207.1 cytochrome p450 140 2114808 cyp140 7560640 cyp140 Mycobacterium bovis BCG str. Tokyo 172 cytochrome p450 140 YP_002644955.1 2113492 R 561275 CDS YP_002644956.1 224990269 7563166 complement(2114858..2115280) 1 NC_012207.1 lipoprotein 2115280 lppE 7563166 lppE Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644956.1 2114858 R 561275 CDS YP_002644957.1 224990270 7560470 complement(2115321..2116154) 1 NC_012207.1 short chain dehydrogenase 2116154 7560470 JTY_1903 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002644957.1 2115321 R 561275 CDS YP_002644958.1 224990271 7560641 complement(2116182..2116658) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 15 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (158 aa versus 153 aa); hypothetical protein 2116658 7560641 JTY_1904 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644958.1 2116182 R 561275 CDS YP_002644959.1 224990272 7560642 complement(2116697..2117227) 1 NC_012207.1 resuscitation-promoting factor 2117227 rpfC 7560642 rpfC Mycobacterium bovis BCG str. Tokyo 172 resuscitation-promoting factor YP_002644959.1 2116697 R 561275 CDS YP_002644960.1 224990273 7561598 complement(2117239..2117838) 1 NC_012207.1 catalyzes the interconversion of chorismate to prephenate; chorismate mutase 2117838 7561598 JTY_1906 Mycobacterium bovis BCG str. Tokyo 172 chorismate mutase YP_002644960.1 2117239 R 561275 CDS YP_002644961.1 224990274 7560643 complement(2117856..2118833) 1 NC_012207.1 Differs from Rv1886c and Mb1918c by 1aa, L140F; antigen 85-B 2118833 fbpB 7560643 fbpB Mycobacterium bovis BCG str. Tokyo 172 antigen 85-B YP_002644961.1 2117856 R 561275 CDS YP_002644962.1 224990275 7563401 2119224..2120366 1 NC_012207.1 Differs from Rv1887 and Mb1919 by 1aa, C121Y in BCG Pasteur and BCG Tokyo; hypothetical protein 2120366 7563401 JTY_1908 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644962.1 2119224 D 561275 CDS YP_002644963.1 224990276 7560644 complement(2120336..2121055) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 10 bp insertion (*-TCCGATCACC) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv (239 aa versus 186 aa); transmembrane protein 2121055 7560644 JTY_1909 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002644963.1 2120336 R 561275 CDS YP_002644964.1 224990277 7560645 complement(2121420..2121593) 1 NC_012207.1 hypothetical protein 2121593 7560645 JTY_1910 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644964.1 2121420 R 561275 CDS YP_002644965.1 224990278 7560646 complement(2121637..2121993) 1 NC_012207.1 hypothetical protein 2121993 7560646 JTY_1911 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644965.1 2121637 R 561275 CDS YP_002644966.1 224990279 7560647 complement(2122052..2122663) 1 NC_012207.1 hypothetical protein 2122663 7560647 JTY_1912 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644966.1 2122052 R 561275 CDS YP_002644967.1 224990280 7560648 2122717..2123124 1 NC_012207.1 hypothetical protein 2123124 7560648 JTY_1913 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644967.1 2122717 D 561275 CDS YP_002644968.1 224990281 7560649 2123141..2123452 1 NC_012207.1 hypothetical protein 2123452 7560649 JTY_1914 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644968.1 2123141 D 561275 CDS YP_002644969.1 224990282 7560650 2123462..2123680 1 NC_012207.1 hypothetical protein 2123680 7560650 JTY_1915 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644969.1 2123462 D 561275 CDS YP_002644970.1 224990283 7560651 complement(2123715..2124845) 1 NC_012207.1 hypothetical protein 2124845 7560651 JTY_1916 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644970.1 2123715 R 561275 CDS YP_002644971.1 224990284 7560652 2125497..2125820 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1895 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, two frameshifts due to a single base deletion (A-*) and a single base insertion (*-T), consecutively, splits Rv1895 into 2 main parts, Mb1928 and Mb1929; dehydrogenase 2125820 7560652 JTY_1917 Mycobacterium bovis BCG str. Tokyo 172 dehydrogenase YP_002644971.1 2125497 D 561275 CDS YP_002644972.1 224990285 7560653 2125817..2126521 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv1895 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, two frameshifts due to a single base deletion (A-*) and a single base insertion (*-T), consecutively, splits Rv1895 into 2 main parts, Mb1928 and Mb1929; dehydrogenase 2126521 7560653 JTY_1918 Mycobacterium bovis BCG str. Tokyo 172 dehydrogenase YP_002644972.1 2125817 D 561275 CDS YP_002644973.1 224990286 7560654 complement(2126511..2127422) 1 NC_012207.1 hypothetical protein 2127422 7560654 JTY_1919 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644973.1 2126511 R 561275 CDS YP_002644974.1 224990287 7560655 complement(2127427..2127858) 1 NC_012207.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 2127858 7560655 JTY_1920 Mycobacterium bovis BCG str. Tokyo 172 D-tyrosyl-tRNA(Tyr) deacylase YP_002644974.1 2127427 R 561275 CDS YP_002644975.1 224990288 7560656 2127916..2128224 1 NC_012207.1 hypothetical protein 2128224 7560656 JTY_1921 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644975.1 2127916 D 561275 CDS YP_002644976.1 224990289 7560657 complement(2128190..2129266) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (358 aa versus 343 aa); lipoprotein 2129266 lppD 7560657 lppD Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644976.1 2128190 R 561275 CDS YP_002644977.1 224990290 7560469 complement(2129266..2130654) 1 NC_012207.1 Differs from Rv1900c and Mb1935c by 1aa, M204I and R170Q, respectively, in BCG Pasteur and BCG Tokyo; lignin peroxidase 2130654 lipJ 7560469 lipJ Mycobacterium bovis BCG str. Tokyo 172 lignin peroxidase YP_002644977.1 2129266 R 561275 CDS YP_002644978.1 224990291 7562838 2130683..2131975 1 NC_012207.1 competence damage-inducible protein A 2131975 cinA 7562838 cinA Mycobacterium bovis BCG str. Tokyo 172 competence damage-inducible protein A YP_002644978.1 2130683 D 561275 CDS YP_002644979.1 224990292 7562104 complement(2132027..2133295) 1 NC_012207.1 sialic acid-transport integral membrane protein 2133295 nanT 7562104 nanT Mycobacterium bovis BCG str. Tokyo 172 sialic acid-transport integral membrane protein YP_002644979.1 2132027 R 561275 CDS YP_002644980.1 224990293 7563592 2133385..2133789 1 NC_012207.1 hypothetical protein 2133789 7563592 JTY_1926 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644980.1 2133385 D 561275 CDS YP_002644981.1 224990294 7560658 2133975..2134406 1 NC_012207.1 Differs from Rv1904 by 1aa, M130T in BCG Pasteur and BCG Tokyo; hypothetical protein 2134406 7560658 JTY_1927 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644981.1 2133975 D 561275 CDS YP_002644982.1 224990295 7560659 complement(2134454..2135416) 1 NC_012207.1 Differs from Rv1905c by 1aa, T240P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; D-amino acid oxidase 2135416 aao 7560659 aao Mycobacterium bovis BCG str. Tokyo 172 D-amino acid oxidase YP_002644982.1 2134454 R 561275 CDS YP_002644983.1 224990296 7564328 complement(2135446..2135916) 1 NC_012207.1 hypothetical protein 2135916 7564328 JTY_1929 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644983.1 2135446 R 561275 CDS YP_002644984.1 224990297 7560660 complement(2136256..2136903) 1 NC_012207.1 hypothetical protein 2136903 7560660 JTY_1930 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644984.1 2136256 R 561275 CDS YP_002644985.1 224990298 7560661 complement(2136910..2139132) 1 NC_012207.1 Differs from Rv1908c by 1aa, L463R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; catalase-peroxidase-peroxynitritase T 2139132 katG 7560661 katG Mycobacterium bovis BCG str. Tokyo 172 catalase-peroxidase-peroxynitritase T YP_002644985.1 2136910 R 561275 CDS YP_002644986.1 224990299 7562800 complement(2139170..2139622) 1 NC_012207.1 Differs from Rv1909c and Mb1944c by 1aa, V46A in BCG Pasteur and BCG Tokyo; ferric uptake regulation protein 2139622 furA 7562800 furA Mycobacterium bovis BCG str. Tokyo 172 ferric uptake regulation protein YP_002644986.1 2139170 R 561275 CDS YP_002644987.1 224990300 7561886 complement(2139727..2140320) 1 NC_012207.1 hypothetical protein 2140320 7561886 JTY_1933 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644987.1 2139727 R 561275 CDS YP_002644988.1 224990301 7560662 complement(2140403..2141008) 1 NC_012207.1 lipoprotein 2141008 lppC 7560662 lppC Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644988.1 2140403 R 561275 CDS YP_002644989.1 224990302 7560468 complement(2141108..2142112) 1 NC_012207.1 Differs from Rv1912c by 1aa, G328D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 2142112 fadB5 7560468 fadB5 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002644989.1 2141108 R 561275 CDS YP_002644990.1 224990303 7562914 2142212..2142964 1 NC_012207.1 Differs from Rv1913 and Mb1948 by 1aa, C7R in BCG Pasteur and BCG Tokyo; hypothetical protein 2142964 7562914 JTY_1936 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644990.1 2142212 D 561275 CDS YP_002644991.1 224990304 7560663 complement(2142942..2143349) 1 NC_012207.1 hypothetical protein 2143349 7560663 JTY_1937 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644991.1 2142942 R 561275 CDS YP_002644992.1 224990305 7560664 2143484..2145784 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, aceAa and aceAb exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base insertion (*-T) leads to a single product; isocitrate lyase 2145784 aceA 7560664 aceA Mycobacterium bovis BCG str. Tokyo 172 isocitrate lyase YP_002644992.1 2143484 D 561275 CDS YP_002644993.1 224990306 7563927 complement(2145954..2151461) 1 NC_012207.1 Equivalent to Mb1951c and Rv1917c but differs by several in-frame insertion and deletion events. Differs from Mb1951c by 69 bp insertion, 69 bp deletion and 225 bp deletion. Differs from Rv1917c by deletions of 12 and 138 bp, insertions of 552 and 150 bp, and substitution of 52bp by 628 bp in BCG Pasteur and BCG Tokyo; PPE family protein 2151461 PPE34 7563927 PPE34 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644993.1 2145954 R 561275 CDS YP_002644994.1 224990307 7562175 complement(2152886..2154763) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PPE35 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-T) splits PPE35 into 2 parts, PPE35a and PPE35b. Differs from Mb1953c by 1aa, F565V in Mycobacterium bovis BCG Pasteur and BCG Tokyo.; PPE family protein 2154763 PPE35a 7562175 PPE35a Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002644994.1 2152886 R 561275 CDS YP_002644995.1 224990308 7562174 complement(2155212..2155676) 1 NC_012207.1 hypothetical protein 2155676 7562174 JTY_1942 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644995.1 2155212 R 561275 CDS YP_002644996.1 224990309 7560665 2155774..2156637 1 NC_012207.1 Differs from Rv1920 by 1aa, I130M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2156637 7560665 JTY_1943 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002644996.1 2155774 D 561275 CDS YP_002644997.1 224990310 7560666 complement(2156675..2157946) 1 NC_012207.1 lipoprotein 2157946 lppF 7560666 lppF Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644997.1 2156675 R 561275 CDS YP_002644998.1 224990311 7560471 2158218..2159333 1 NC_012207.1 lipoprotein 2159333 7560471 JTY_1945 Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002644998.1 2158218 D 561275 CDS YP_002644999.1 224990312 7560667 2159324..2160664 1 NC_012207.1 Differs from Rv1923 by 2aa, D73G, N181D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteyr, and BCG Tokyo; lipase 2160664 lipD 7560667 lipD Mycobacterium bovis BCG str. Tokyo 172 lipase YP_002644999.1 2159324 D 561275 CDS YP_002645000.1 224990313 7562832 complement(2160701..2161081) 1 NC_012207.1 hypothetical protein 2161081 7562832 JTY_1947 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645000.1 2160701 R 561275 CDS YP_002645001.1 224990314 7560668 2161238..2163100 1 NC_012207.1 activates fatty acids by binding to coenzyme A; fatty-acid--CoA ligase 2163100 fadD31 7560668 fadD31 Mycobacterium bovis BCG str. Tokyo 172 fatty-acid--CoA ligase YP_002645001.1 2161238 D 561275 CDS YP_002645002.1 224990315 7562937 complement(2163108..2163587) 1 NC_012207.1 hypothetical protein 2163587 mpt63 7562937 mpt63 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645002.1 2163108 R 561275 CDS YP_002645003.1 224990316 7563555 2163824..2164597 1 NC_012207.1 hypothetical protein 2164597 7563555 JTY_1950 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645003.1 2163824 D 561275 CDS YP_002645004.1 224990317 7560669 complement(2164601..2165368) 1 NC_012207.1 short chain dehydrogenase 2165368 7560669 JTY_1951 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002645004.1 2164601 R 561275 CDS YP_002645005.1 224990318 7560670 complement(2165413..2166057) 1 NC_012207.1 hypothetical protein 2166057 7560670 JTY_1952 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645005.1 2165413 R 561275 CDS YP_002645006.1 224990319 7560671 complement(2166069..2166593) 1 NC_012207.1 hypothetical protein 2166593 7560671 JTY_1953 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645006.1 2166069 R 561275 CDS YP_002645007.1 224990320 7560672 complement(2166611..2167390) 1 NC_012207.1 transcriptional regulatory protein 2167390 7560672 JTY_1954 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645007.1 2166611 R 561275 CDS YP_002645008.1 224990321 7560673 2167523..2168020 1 NC_012207.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 2168020 tpx 7560673 tpx Mycobacterium bovis BCG str. Tokyo 172 thiol peroxidase YP_002645008.1 2167523 D 561275 CDS YP_002645009.1 224990322 7561865 complement(2168017..2169108) 1 NC_012207.1 acyl-CoA dehydrogenase 2169108 fadE18 7561865 fadE18 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002645009.1 2168017 R 561275 CDS YP_002645010.1 224990323 7563366 complement(2169110..2170339) 1 NC_012207.1 acyl-CoA dehydrogenase 2170339 fadE17 7563366 fadE17 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002645010.1 2169110 R 561275 CDS YP_002645011.1 224990324 7563365 complement(2170354..2171310) 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2171310 echA13 7563365 echA13 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002645011.1 2170354 R 561275 CDS YP_002645012.1 224990325 7561525 2171535..2172644 1 NC_012207.1 monooxygenase 2172644 7561525 JTY_1959 Mycobacterium bovis BCG str. Tokyo 172 monooxygenase YP_002645012.1 2171535 D 561275 CDS YP_002645013.1 224990326 7560674 2172647..2175166 1 NC_012207.1 oxygenase 2175166 7560674 JTY_1960 Mycobacterium bovis BCG str. Tokyo 172 oxygenase YP_002645013.1 2172647 D 561275 CDS YP_002645014.1 224990327 7560675 2175178..2176248 1 NC_012207.1 epoxide hydrolase 2176248 ephB 7560675 ephB Mycobacterium bovis BCG str. Tokyo 172 epoxide hydrolase YP_002645014.1 2175178 D 561275 CDS YP_002645015.1 224990328 7562867 2176245..2176760 1 NC_012207.1 In Mycobacterium bovis, a single base deletion (T-*) leads to a longer product with a different COOH part compared to its homologs in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (244 aa versus 171 aa); oxidoreductase 2176760 7562867 JTY_1962 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002645015.1 2176245 D 561275 CDS YP_002645016.1 224990329 7560676 2176757..2177818 1 NC_012207.1 GTP cyclohydrolase II; riboflavin biosynthesis protein 2177818 ribA1 7560676 ribA1 Mycobacterium bovis BCG str. Tokyo 172 riboflavin biosynthesis protein YP_002645016.1 2176757 D 561275 CDS YP_002645017.1 224990330 7561571 2177815..2178585 1 NC_012207.1 short-chain type dehydrogenase/reductase 2178585 7561571 JTY_1964 Mycobacterium bovis BCG str. Tokyo 172 short-chain type dehydrogenase/reductase YP_002645017.1 2177815 D 561275 CDS YP_002645018.1 224990331 7560677 complement(2178795..2179124) 1 NC_012207.1 hypothetical protein 2179124 7560677 JTY_1965 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645018.1 2178795 R 561275 CDS YP_002645019.1 224990332 7560678 complement(2179121..2179498) 1 NC_012207.1 hypothetical protein 2179498 7560678 JTY_1966 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645019.1 2179121 R 561275 CDS YP_002645020.1 224990333 7560679 complement(2179495..2180085) 1 NC_012207.1 Differs from Rv1944c and Mb1979c by 2aa, E4D, A5T, due to 2 bp substitution ta-cc in BCG Pasteur and BCG Tokyo; hypothetical protein 2180085 7560679 JTY_1967 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645020.1 2179495 R 561275 CDS YP_002645021.1 224990334 7564322 2180140..2181504 1 NC_012207.1 Differs from Mb1980 and Rv1945 by substitutions of 44, 29, 2, 10 and 34 bp, or 44, 29, 4, 2, 10 and 34 bp, respectively. Corresponding to 10 aa from Rv1945, L242V, N264H, A267G, F268L, A271G, K285R, I291V, N328H, H417K and P426A, and to 9 aa from Mb1980, N264H, A267G, F268L, A271G, K285R, I291V, N328H, H417K and P426A in BCG Pasteur and BCG Tokyo; hypothetical protein 2181504 7564322 JTY_1968 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645021.1 2180140 D 561275 CDS YP_002645022.1 224990335 7560680 complement(2181659..2182111) 1 NC_012207.1 Differs from Rv1946c by 1aa, T98A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 2182111 lppG 7560680 lppG Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645022.1 2181659 R 561275 CDS YP_002645023.1 224990336 7560472 2182175..2182576 1 NC_012207.1 hypothetical protein 2182576 7560472 JTY_1970 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645023.1 2182175 D 561275 CDS YP_002645024.1 224990337 7560681 complement(2182865..2183215) 1 NC_012207.1 Differs from Rv1948c by 1aa, R5G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2183215 7560681 JTY_1971 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645024.1 2182865 R 561275 CDS YP_002645025.1 224990338 7560682 complement(2183226..2184128) 1 NC_012207.1 Differs from Rv1949c by 1aa, L188F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2184128 7560682 JTY_1972 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645025.1 2183226 R 561275 CDS YP_002645026.1 224990339 7560683 complement(2184149..2184340) 1 NC_012207.1 hypothetical protein 2184340 7560683 JTY_1973 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645026.1 2184149 R 561275 CDS YP_002645027.1 224990340 7560684 complement(2184341..2184637) 1 NC_012207.1 hypothetical protein 2184637 7560684 JTY_1974 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645027.1 2184341 R 561275 CDS YP_002645028.1 224990341 7560685 2184877..2185092 1 NC_012207.1 hypothetical protein 2185092 7560685 JTY_1975 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645028.1 2184877 D 561275 CDS YP_002645029.1 224990342 7560686 2185089..2185400 1 NC_012207.1 hypothetical protein 2185400 7560686 JTY_1976 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645029.1 2185089 D 561275 CDS YP_002645030.1 224990343 7560687 complement(2185374..2185895) 1 NC_012207.1 Differs from Rv1954c by 1aa, R150H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2185895 7560687 JTY_1977 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645030.1 2185374 R 561275 CDS YP_002645031.1 224990344 7560688 2185735..2186247 1 NC_012207.1 hypothetical protein 2186247 7560688 JTY_1978 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645031.1 2185735 D 561275 CDS YP_002645032.1 224990345 7560689 2186289..2186738 1 NC_012207.1 transcriptional regulatory protein 2186738 7560689 JTY_1979 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645032.1 2186289 D 561275 CDS YP_002645033.1 224990346 7560690 2186735..2187280 1 NC_012207.1 hypothetical protein 2187280 7560690 JTY_1980 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645033.1 2186735 D 561275 CDS YP_002645034.1 224990347 7560691 complement(2187169..2187783) 1 NC_012207.1 hypothetical protein 2187783 7560691 JTY_1981 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645034.1 2187169 R 561275 CDS YP_002645035.1 224990348 7560692 complement(2187832..2188128) 1 NC_012207.1 hypothetical protein 2188128 7560692 JTY_1982 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645035.1 2187832 R 561275 CDS YP_002645036.1 224990349 7560693 complement(2188125..2188376) 1 NC_012207.1 hypothetical protein 2188376 7560693 JTY_1983 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645036.1 2188125 R 561275 CDS YP_002645037.1 224990350 7560694 2188363..2188857 1 NC_012207.1 hypothetical protein 2188857 7560694 JTY_1984 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645037.1 2188363 D 561275 CDS YP_002645038.1 224990351 7560695 complement(2189017..2189424) 1 NC_012207.1 hypothetical protein 2189424 7560695 JTY_1985 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645038.1 2189017 R 561275 CDS YP_002645039.1 224990352 7560696 complement(2189428..2189700) 1 NC_012207.1 antitoxin 2189700 7560696 JTY_1986 Mycobacterium bovis BCG str. Tokyo 172 antitoxin YP_002645039.1 2189428 R 561275 CDS YP_002645040.1 224990353 7560697 complement(2189733..2190953) 1 NC_012207.1 transcriptional regulatory protein 2190953 7560697 JTY_1987 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645040.1 2189733 R 561275 CDS YP_002645041.1 224990354 7560698 2191852..2192256 1 NC_012207.1 In Mycobacterium bovis Mycobacterium bovis BCG Pasteur and BCG Tokyo, a large deletion of 12719 bp (RD7) leads to the loss of the COOH part of Rv1964|yrbE3A, the entire mce3 operon and the following genes up to Rv1978, compared to Mycobacterium tuberculosis strain H37Rv. Follow by a second deletion of 10287bp, RD2 region (only in Mycobacterium bovis BCG Pasteur), which removes genes Rv1979c-Rv1787 and merges truncated part of Rv1978 and Rv1988 compared to Mycobacterium tuberculosis strain H37Rv; hypothetical protein 2192256 yrbE3A 7560698 yrbE3A Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645041.1 2191852 D 561275 CDS YP_002645042.1 224990355 7561454 2192341..2193189 1 NC_012207.1 hypothetical protein 2193189 7561454 JTY_1989 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645042.1 2192341 D 561275 CDS YP_002645043.1 224990356 7560699 complement(2193152..2194597) 1 NC_012207.1 Differ from Rv1979c by 2aa, G286D, I457V in Mycobacterium bovis and Mycobacterium bovis BCG Tokyo.; permease 2194597 7560699 JTY_1990 Mycobacterium bovis BCG str. Tokyo 172 permease YP_002645043.1 2193152 R 561275 CDS YP_002645044.1 224990357 7560700 complement(2194776..2195462) 1 NC_012207.1 Equivalent to Mycobacterium bovis (Mb2002c) and Mycobacterium tuberculosis H37Rv (Rv1980c) in Mycobacterium bovis BCG Tokyo.; antigen MPT64/MPB64; hypothetical protein 2195462 mpt64 7560700 mpt64 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645044.1 2194776 R 561275 CDS YP_002645045.1 224990358 7563556 complement(2195653..2196621) 1 NC_012207.1 Differ from Rv1981c by 1aa, R5L in Mycobacterium bovis and Mycobacterium bovis BCG Tokyo.; ribonucleotide-diphosphate reductase subunit beta 2196621 nrdF1 7563556 nrdF1 Mycobacterium bovis BCG str. Tokyo 172 ribonucleotide-diphosphate reductase subunit beta YP_002645045.1 2195653 R 561275 CDS YP_002645046.1 224990359 7562466 complement(2196846..2197265) 1 NC_012207.1 Equivalent to Mycobacterium bovis (Mb2004c) and Mycobacterium tuberculosis H37Rv (Rv1982c) in Mycobacterium bovis BCG Tokyo; hypothetical protein 2197265 7562466 JTY_1993 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645046.1 2196846 R 561275 CDS YP_002645047.1 224990360 7560701 2197677..2199353 1 NC_012207.1 Differ from Rv1983 by 1aa, T220A in Mycobacterium bovis and Mycobacterium bovis BCG Tokyo.; PE-PGRS family protein 2199353 PE_PGRS35 7560701 PE_PGRS35 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002645047.1 2197677 D 561275 CDS YP_002645048.1 224990361 7561779 complement(2199341..2199994) 1 NC_012207.1 Equivalent to Mycobacterium bovis (Mb2006c) and Mycobacterium tuberculosis H37Rv (Rv1984c) in Mycobacterium bovis BCG Tokyo; cutinase precursor 2199994 cfp21 7561779 cfp21 Mycobacterium bovis BCG str. Tokyo 172 cutinase precursor YP_002645048.1 2199341 R 561275 CDS YP_002645049.1 224990362 7562099 complement(2200424..2201335) 1 NC_012207.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 2201335 7562099 JTY_1996 Mycobacterium bovis BCG str. Tokyo 172 chromosome replication initiation inhibitor protein YP_002645049.1 2200424 R 561275 CDS YP_002645050.1 224990363 7560702 2201444..2202043 1 NC_012207.1 Equivalent to Mycobacterium bovis (Mb2008) and Mycobacterium tuberculosis H37Rv (Rv1986) in Mycobacterium bovis BCG Tokyo; hypothetical protein 2202043 7560702 JTY_1997 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645050.1 2201444 D 561275 CDS YP_002645051.1 224990364 7560703 2202459..2202887 1 NC_012207.1 Equivalent to Mycobacterium bovis (Mb2009) and Mycobacterium tuberculosis H37Rv (Rv1987) in Mycobacterium bovis BCG Tokyo; chitinase 2202887 7560703 JTY_1998 Mycobacterium bovis BCG str. Tokyo 172 chitinase YP_002645051.1 2202459 D 561275 CDS YP_002645052.1 224990365 7560704 2203113..2203652 1 NC_012207.1 Equivalent to Mycobacterium bovis (Mb2010) and Mycobacterium tuberculosis H37Rv (Rv1988)in Mycobacterium bovis BCG Tokyo; methyltransferase 2203652 7560704 JTY_1999 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase YP_002645052.1 2203113 D 561275 CDS YP_002645053.1 224990366 7560705 complement(2204172..2204732) 1 NC_012207.1 hypothetical protein 2204732 7560705 JTY_2000 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645053.1 2204172 R 561275 CDS YP_002645054.1 224990367 7560706 complement(2204729..2205070) 1 NC_012207.1 transcriptional regulatory protein 2205070 7560706 JTY_2001 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645054.1 2204729 R 561275 CDS YP_002645055.1 224990368 7560707 complement(2205314..2205649) 1 NC_012207.1 dehydrogenase 2205649 7560707 JTY_2002 Mycobacterium bovis BCG str. Tokyo 172 dehydrogenase YP_002645055.1 2205314 R 561275 CDS YP_002645056.1 224990369 7560708 complement(2205738..2206082) 1 NC_012207.1 hypothetical protein 2206082 7560708 JTY_2003 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645056.1 2205738 R 561275 CDS YP_002645057.1 224990370 7560709 complement(2206424..2208739) 1 NC_012207.1 metal cation transporter P-type ATPase G 2208739 ctpG 7560709 ctpG Mycobacterium bovis BCG str. Tokyo 172 metal cation transporter P-type ATPase G YP_002645057.1 2206424 R 561275 CDS YP_002645058.1 224990371 7563137 complement(2208736..2209008) 1 NC_012207.1 hypothetical protein 2209008 7563137 JTY_2005 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645058.1 2208736 R 561275 CDS YP_002645059.1 224990372 7560710 complement(2209061..2209417) 1 NC_012207.1 transcriptional regulatory protein 2209417 7560710 JTY_2006 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645059.1 2209061 R 561275 CDS YP_002645060.1 224990373 7560711 2209574..2210341 1 NC_012207.1 hypothetical protein 2210341 7560711 JTY_2007 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645060.1 2209574 D 561275 CDS YP_002645061.1 224990374 7561204 2210437..2211390 1 NC_012207.1 hypothetical protein 2211390 7561204 JTY_2008 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645061.1 2210437 D 561275 CDS YP_002645062.1 224990375 7561205 2211592..2214309 1 NC_012207.1 Differs from Rv1997 and Mb2020 by 1aa, D138E in BCG Pasteur and BCG Tokyo; metal cation transporter P-type ATPase A 2214309 ctpF 7561205 ctpF Mycobacterium bovis BCG str. Tokyo 172 metal cation transporter P-type ATPase A YP_002645062.1 2211592 D 561275 CDS YP_002645063.1 224990376 7563136 complement(2214378..2215154) 1 NC_012207.1 Differs from Rv1998c by 1aa, R230S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2215154 7563136 JTY_2010 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645063.1 2214378 R 561275 CDS YP_002645064.1 224990377 7561206 complement(2215249..2216571) 1 NC_012207.1 integral membrane protein 2216571 7561206 JTY_2011 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002645064.1 2215249 R 561275 CDS YP_002645065.1 224990378 7561207 2216642..2218255 1 NC_012207.1 hypothetical protein 2218255 7561207 JTY_2012 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645065.1 2216642 D 561275 CDS YP_002645066.1 224990379 7561208 2218265..2219017 1 NC_012207.1 Differs from Rv2001 by 1aa, H113R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2219017 7561208 JTY_2013 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645066.1 2218265 D 561275 CDS YP_002645067.1 224990380 7561209 2219093..2219875 1 NC_012207.1 20-beta-hydroxysteroid dehydrogenase 2219875 fabG3 7561209 fabG3 Mycobacterium bovis BCG str. Tokyo 172 20-beta-hydroxysteroid dehydrogenase YP_002645067.1 2219093 D 561275 CDS YP_002645068.1 224990381 7562901 complement(2219996..2220853) 1 NC_012207.1 hypothetical protein 2220853 7562901 JTY_2015 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645068.1 2219996 R 561275 CDS YP_002645069.1 224990382 7561210 complement(2220911..2222407) 1 NC_012207.1 hypothetical protein 2222407 7561210 JTY_2016 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645069.1 2220911 R 561275 CDS YP_002645070.1 224990383 7561211 complement(2222429..2223316) 1 NC_012207.1 hypothetical protein 2223316 7561211 JTY_2017 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645070.1 2222429 R 561275 CDS YP_002645071.1 224990384 7561212 2223435..2227418 1 NC_012207.1 Differs from Rv2006 and Mb2029 by 1aa, S80G and L1245P, respectively, in BCG Pasteur and BCG Tokyo; trehalose-6-phosphate phosphatase 2227418 otsB1 7561212 otsB1 Mycobacterium bovis BCG str. Tokyo 172 trehalose-6-phosphate phosphatase YP_002645071.1 2223435 D 561275 CDS YP_002645072.1 224990385 7562503 complement(2227517..2227861) 1 NC_012207.1 ferredoxin 2227861 fdxA 7562503 fdxA Mycobacterium bovis BCG str. Tokyo 172 ferredoxin YP_002645072.1 2227517 R 561275 CDS YP_002645073.1 224990386 7563406 complement(2228050..2229375) 1 NC_012207.1 hypothetical protein 2229375 7563406 JTY_2020 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645073.1 2228050 R 561275 CDS YP_002645074.1 224990387 7561213 2229463..2229705 1 NC_012207.1 hypothetical protein 2229705 7561213 JTY_2021 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645074.1 2229463 D 561275 CDS YP_002645075.1 224990388 7561214 2229706..2230104 1 NC_012207.1 hypothetical protein 2230104 7561214 JTY_2022 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645075.1 2229706 D 561275 CDS YP_002645076.1 224990389 7561215 complement(2230287..2230718) 1 NC_012207.1 hypothetical protein 2230718 7561215 JTY_2023 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645076.1 2230287 R 561275 CDS YP_002645077.1 224990390 7561216 2230759..2231253 1 NC_012207.1 hypothetical protein 2231253 7561216 JTY_2024 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645077.1 2230759 D 561275 CDS YP_002645078.1 224990391 7561217 2231957..2232574 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (c-t) at the 5' start, leads to a longer product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (206 aa versus 159 aa); transposase 2232574 7561217 JTY_2025 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002645078.1 2231957 D 561275 CDS YP_002645079.1 224990392 7561218 2232528..2233118 1 NC_012207.1 Identical to Mb2037 including extra 5 aa at C-terminus compared to Rv2014 in Mycobacterium bovis BCG Pasteur and BCG Tokyo; transposase 2233118 7561218 JTY_2026 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002645079.1 2232528 D 561275 CDS YP_002645080.1 224990393 7561219 complement(2233246..2234502) 1 NC_012207.1 Differs from Mb2038c by 1aa S59L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2234502 7561219 JTY_2027 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645080.1 2233246 R 561275 CDS YP_002645081.1 224990394 7561220 2234856..2235431 1 NC_012207.1 hypothetical protein 2235431 7561220 JTY_2028 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645081.1 2234856 D 561275 CDS YP_002645082.1 224990395 7561221 2235428..2236468 1 NC_012207.1 Differs from Rv2017 by 1aa, E262A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical regulatory protein 2236468 7561221 JTY_2029 Mycobacterium bovis BCG str. Tokyo 172 hypothetical regulatory protein YP_002645082.1 2235428 D 561275 CDS YP_002645083.1 224990396 7561222 2236710..2237429 1 NC_012207.1 Differs from Rv2018 by 1aa, G116D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2237429 7561222 JTY_2030 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645083.1 2236710 D 561275 CDS YP_002645084.1 224990397 7561223 2237419..2237835 1 NC_012207.1 hypothetical protein 2237835 7561223 JTY_2031 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645084.1 2237419 D 561275 CDS YP_002645085.1 224990398 7561224 complement(2237851..2238150) 1 NC_012207.1 hypothetical protein 2238150 7561224 JTY_2032 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645085.1 2237851 R 561275 CDS YP_002645086.1 224990399 7561225 complement(2238235..2238540) 1 NC_012207.1 hypothetical protein 2238540 7561225 JTY_2033 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645086.1 2238235 R 561275 CDS YP_002645087.1 224990400 7561226 complement(2238549..2239154) 1 NC_012207.1 hypothetical protein 2239154 7561226 JTY_2034 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645087.1 2238549 R 561275 CDS YP_002645088.1 224990401 7561227 complement(2239179..2239538) 1 NC_012207.1 hypothetical protein 2239538 7561227 JTY_2035 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645088.1 2239179 R 561275 CDS YP_002645089.1 224990402 7561228 complement(2239698..2240375) 1 NC_012207.1 Belongs to the RvD1 region. Absent in Mycobacterium tuberculosis strain H37Rv; hypothetical protein 2240375 7561228 JTY_2036 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645089.1 2239698 R 561275 CDS YP_002645090.1 224990403 7561229 complement(2240770..2241666) 1 NC_012207.1 Belongs to the RvD1 region. Absent in Mycobacterium tuberculosis strain H37Rv. Differs from Mb2048c by 1aa, E139K in Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 2241666 7561229 JTY_2037 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645090.1 2240770 R 561275 CDS YP_002645091.1 224990404 7561230 complement(2241850..2246670) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, a large deletion region (RvD1) exists in between Rv2023 and Rv2024. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 5000 bp insertion at this region results in Mb2049c being a much larger product with a different COOH part (1606 aa versus 515 aa), and in 2 extra genes, Mb2046c and Mb2047c. Differs from N-terminal part of Rv2024c (truncated by RvD1) by 3aa, R47W, G154D, C289R and Mb2049c by 1aa, F341V in BCG Pasteur and BCG Tokyo; hypothetical protein 2246670 7561230 JTY_2038 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645091.1 2241850 R 561275 CDS YP_002645092.1 224990405 7561231 complement(2247180..2248178) 1 NC_012207.1 hypothetical protein 2248178 7561231 JTY_2039 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645092.1 2247180 R 561275 CDS YP_002645093.1 224990406 7561232 complement(2248293..2249177) 1 NC_012207.1 hypothetical protein 2249177 7561232 JTY_2040 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645093.1 2248293 R 561275 CDS YP_002645094.1 224990407 7561233 complement(2249217..2250938) 1 NC_012207.1 Differs from Rv2027c by 1aa, V15L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; histidine kinase response regulator 2250938 7561233 JTY_2041 Mycobacterium bovis BCG str. Tokyo 172 histidine kinase response regulator YP_002645094.1 2249217 R 561275 CDS YP_002645095.1 224990408 7561234 complement(2250999..2251838) 1 NC_012207.1 hypothetical protein 2251838 7561234 JTY_2042 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645095.1 2250999 R 561275 CDS YP_002645096.1 224990409 7561235 complement(2251835..2252854) 1 NC_012207.1 phosphofructokinase 2252854 pfkB 7561235 pfkB Mycobacterium bovis BCG str. Tokyo 172 phosphofructokinase YP_002645096.1 2251835 R 561275 CDS YP_002645097.1 224990410 7562396 complement(2252871..2254916) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, Rv2030c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (G-*) splits Rv2030c into 2 parts, Mb2055c and Mb2056c; hypothetical protein 2254916 7562396 JTY_2044 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645097.1 2252871 R 561275 CDS YP_002645098.1 224990411 7561236 complement(2254928..2255362) 1 NC_012207.1 heat shock protein 2255362 hspX 7561236 hspX Mycobacterium bovis BCG str. Tokyo 172 heat shock protein YP_002645098.1 2254928 R 561275 CDS YP_002645099.1 224990412 7563330 2255559..2256554 1 NC_012207.1 Differs from Rv2032 by 1aa, L318P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2256554 7563330 JTY_2046 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645099.1 2255559 D 561275 CDS YP_002645100.1 224990413 7561237 complement(2256670..2257512) 1 NC_012207.1 hypothetical protein 2257512 7561237 JTY_2047 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645100.1 2256670 R 561275 CDS YP_002645101.1 224990414 7561238 2257724..2258047 1 NC_012207.1 ArsR-type repressor protein 2258047 7561238 JTY_2048 Mycobacterium bovis BCG str. Tokyo 172 ArsR-type repressor protein YP_002645101.1 2257724 D 561275 CDS YP_002645102.1 224990415 7561239 2258044..2258532 1 NC_012207.1 hypothetical protein 2258532 7561239 JTY_2049 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645102.1 2258044 D 561275 CDS YP_002645103.1 224990416 7561240 2258529..2259170 1 NC_012207.1 Differs from Rv2036 by 1aa, V93A due to 2bp substitution cc-tt in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2259170 7561240 JTY_2050 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645103.1 2258529 D 561275 CDS YP_002645104.1 224990417 7561241 complement(2259177..2260151) 1 NC_012207.1 Differs from Rv2037c by 1aa, Y312C in Mycobacterium tuberclosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 2260151 7561241 JTY_2051 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645104.1 2259177 R 561275 CDS YP_002645105.1 224990418 7561242 complement(2260153..2261226) 1 NC_012207.1 sugar-transport ATP-binding protein ABC transporter 2261226 7561242 JTY_2052 Mycobacterium bovis BCG str. Tokyo 172 sugar-transport ATP-binding protein ABC transporter YP_002645105.1 2260153 R 561275 CDS YP_002645106.1 224990419 7561243 complement(2261229..2262071) 1 NC_012207.1 Differs from Rv2039c by 1aa, F131V in Mycobacterium tuberclosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; sugar-transport integral membrane protein ABC transporter 2262071 7561243 JTY_2053 Mycobacterium bovis BCG str. Tokyo 172 sugar-transport integral membrane protein ABC transporter YP_002645106.1 2261229 R 561275 CDS YP_002645107.1 224990420 7561244 complement(2262058..2262960) 1 NC_012207.1 sugar-transport integral membrane protein ABC transporter 2262960 7561244 JTY_2054 Mycobacterium bovis BCG str. Tokyo 172 sugar-transport integral membrane protein ABC transporter YP_002645107.1 2262058 R 561275 CDS YP_002645108.1 224990421 7561245 complement(2262957..2264276) 1 NC_012207.1 sugar-binding lipoprotein 2264276 7561245 JTY_2055 Mycobacterium bovis BCG str. Tokyo 172 sugar-binding lipoprotein YP_002645108.1 2262957 R 561275 CDS YP_002645109.1 224990422 7561246 complement(2264314..2265111) 1 NC_012207.1 hypothetical protein 2265111 7561246 JTY_2056 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645109.1 2264314 R 561275 CDS YP_002645110.1 224990423 7561247 complement(2265111..2265671) 1 NC_012207.1 Differs from Rv2043c by 1aa, D57H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; pyrazinamidase/nicotinamidase 2265671 pncA 7561247 pncA Mycobacterium bovis BCG str. Tokyo 172 pyrazinamidase/nicotinamidase YP_002645110.1 2265111 R 561275 CDS YP_002645111.1 224990424 7562134 complement(2265712..2266029) 1 NC_012207.1 hypothetical protein 2266029 7562134 JTY_2058 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645111.1 2265712 R 561275 CDS YP_002645112.1 224990425 7561248 complement(2266115..2267650) 1 NC_012207.1 carboxylesterase 2267650 lipT 7561248 lipT Mycobacterium bovis BCG str. Tokyo 172 carboxylesterase YP_002645112.1 2266115 R 561275 CDS YP_002645113.1 224990426 7562846 2267699..2268355 1 NC_012207.1 Differs from Rv2046 by 1aa, P17S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 2268355 lppI 7562846 lppI Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645113.1 2267699 D 561275 CDS YP_002645114.1 224990427 7560474 complement(2268392..2270956) 1 NC_012207.1 hypothetical protein 2270956 7560474 JTY_2061 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645114.1 2268392 R 561275 CDS YP_002645115.1 224990428 7561249 complement(2270961..2283416) 1 NC_012207.1 Differs from Mb2074c and Rv2048c in several positions due to various substitutions, transitions and transversions in BCG Pasteur and BCG Tokyo; polyketide synthase 2283416 pks12 7561249 pks12 Mycobacterium bovis BCG str. Tokyo 172 polyketide synthase YP_002645115.1 2270961 R 561275 CDS YP_002645116.1 224990429 7562443 complement(2283723..2283947) 1 NC_012207.1 hypothetical protein 2283947 7562443 JTY_2063 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645116.1 2283723 R 561275 CDS YP_002645117.1 224990430 7561250 2284251..2284586 1 NC_012207.1 hypothetical protein 2284586 7561250 JTY_2064 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645117.1 2284251 D 561275 CDS YP_002645118.1 224990431 7561251 complement(2284561..2287185) 1 NC_012207.1 polyprenol-monophosphomannose synthase 2287185 ppm1 7561251 ppm1 Mycobacterium bovis BCG str. Tokyo 172 polyprenol-monophosphomannose synthase YP_002645118.1 2284561 R 561275 CDS YP_002645119.1 224990432 7560809 complement(2287343..2288947) 1 NC_012207.1 hypothetical protein 2288947 7560809 JTY_2066 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645119.1 2287343 R 561275 CDS YP_002645120.1 224990433 7561252 complement(2288952..2289479) 1 NC_012207.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA 2289479 fxsA 7561252 fxsA Mycobacterium bovis BCG str. Tokyo 172 FxsA YP_002645120.1 2288952 R 561275 CDS YP_002645121.1 224990434 7561890 2289555..2290268 1 NC_012207.1 hypothetical protein 2290268 7561890 JTY_2068 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645121.1 2289555 D 561275 CDS YP_002645122.1 224990435 7561253 complement(2290517..2290783) 1 NC_012207.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 2290783 rpsR2 7561253 rpsR2 Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S18 YP_002645122.1 2290517 R 561275 CDS YP_002645123.1 224990436 7560747 complement(2290784..2291089) 1 NC_012207.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 2291089 rpsN 7560747 rpsN Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S14 YP_002645123.1 2290784 R 561275 CDS YP_002645124.1 224990437 7560742 complement(2291091..2291255) 1 NC_012207.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 2291255 rpmG 7560742 rpmG Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L33 YP_002645124.1 2291091 R 561275 CDS YP_002645125.1 224990438 7560720 complement(2291255..2291491) 1 NC_012207.1 required for 70S ribosome assembly; 50S ribosomal protein L28 2291491 rpmB 7560720 rpmB Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L28 YP_002645125.1 2291255 R 561275 CDS YP_002645126.1 224990439 7560715 2291604..2293139 1 NC_012207.1 hypothetical protein 2293139 7560715 JTY_2073 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645126.1 2291604 D 561275 CDS YP_002645127.1 224990440 7561254 complement(2293111..2293515) 1 NC_012207.1 hypothetical protein 2293515 7561254 JTY_2074 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645127.1 2293111 R 561275 CDS YP_002645128.1 224990441 7561255 complement(2293599..2297183) 1 NC_012207.1 with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism; cobaltochelatase subunit CobN 2297183 cobN 7561255 cobN Mycobacterium bovis BCG str. Tokyo 172 cobaltochelatase subunit CobN YP_002645128.1 2293599 R 561275 CDS YP_002645129.1 224990442 7563113 2297261..2297494 1 NC_012207.1 hypothetical protein 2297494 7563113 JTY_2076 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645129.1 2297261 D 561275 CDS YP_002645130.1 224990443 7561256 2297881..2298972 1 NC_012207.1 cobalamin biosynthesis protein 2298972 cobG 7561256 cobG Mycobacterium bovis BCG str. Tokyo 172 cobalamin biosynthesis protein YP_002645130.1 2297881 D 561275 CDS YP_002645131.1 224990444 7563106 2298982..2299608 1 NC_012207.1 catalyzes the interconversion of precorrin-8X and hydrogenobyrinate; precorrin-8X methylmutase 2299608 cobH 7563106 cobH Mycobacterium bovis BCG str. Tokyo 172 precorrin-8X methylmutase YP_002645131.1 2298982 D 561275 CDS YP_002645132.1 224990445 7563107 2299605..2301131 1 NC_012207.1 S-adenosyl-L-methionine-precorrin-2 methyl transferase, precorrin-3 methylase; CobI-CobJ fusion protein 2301131 cobI 7563107 cobI Mycobacterium bovis BCG str. Tokyo 172 CobI-CobJ fusion protein YP_002645132.1 2299605 D 561275 CDS YP_002645133.1 224990446 7563108 complement(2301077..2302300) 1 NC_012207.1 hypothetical protein 2302300 7563108 JTY_2080 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645133.1 2301077 R 561275 CDS YP_002645134.1 224990447 7561257 complement(2302316..2303239) 1 NC_012207.1 class A beta-lactamase 2303239 blaC 7561257 blaC Mycobacterium bovis BCG str. Tokyo 172 class A beta-lactamase YP_002645134.1 2302316 R 561275 CDS YP_002645135.1 224990448 7562073 2303374..2303931 1 NC_012207.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigC 2303931 sigC 7562073 sigC Mycobacterium bovis BCG str. Tokyo 172 RNA polymerase sigma factor SigC YP_002645135.1 2303374 D 561275 CDS YP_002645136.1 224990449 7560791 complement(2303921..2304616) 1 NC_012207.1 CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; cobalt-precorrin-6x reductase 2304616 cobK 7560791 cobK Mycobacterium bovis BCG str. Tokyo 172 cobalt-precorrin-6x reductase YP_002645136.1 2303921 R 561275 CDS YP_002645137.1 224990450 7563109 complement(2304653..2305408) 1 NC_012207.1 Differs from Rv2071c by 1aa, M145I in BCG Pasteur and BCG Tokyo; precorrin-4 C11-methyltransferase 2305408 cobM 7563109 cobM Mycobacterium bovis BCG str. Tokyo 172 precorrin-4 C11-methyltransferase YP_002645137.1 2304653 R 561275 CDS YP_002645138.1 224990451 7563112 complement(2305405..2306289) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 2029 bp deletion (H37Rv.2330073-2332101-*)(RD9) leads to the loss of the NH2 part of cobL, the entire Rv2073 and Rv2074, and the COOH part of Mb2100c. In addition, while cobL exists as a single gene in Mycobacterium tuberculosis strain H37Rv, in Mycobacterium bovis a frameshift due to a single base insertion (*-T) splits cobL into 2 parts, cobLa and cobLb; precorrin-6y methyltransferase 2306289 cobLb 7563112 cobLb Mycobacterium bovis BCG str. Tokyo 172 precorrin-6y methyltransferase YP_002645138.1 2305405 R 561275 CDS YP_002645139.1 224990452 7563111 complement(2306231..2306419) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 2029 bp deletion (H37Rv.2330073-2332101-*)(RD9) leads to the loss of the NH2 part of cobL, the entire Rv2073 and Rv2074, and the COOH part of Mb2100c. In addition, while cobL exists as a single gene in Mycobacterium tuberculosis strain H37Rv, in Mycobacterium bovis a frameshift due to a single base insertion (*-T) splits cobL into 2 parts, cobLa and cobLb; precorrin-6y methyltransferase 2306419 cobLa 7563111 cobLa Mycobacterium bovis BCG str. Tokyo 172 precorrin-6y methyltransferase YP_002645139.1 2306231 R 561275 CDS YP_002645140.1 224990453 7563110 complement(2306494..2307282) 1 NC_012207.1 In Mycobacterium bovis AF2122/97, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 2029 bp deletion(RD9) leads to the loss of the COOH part of Mb2100c, the entire Rv2074 and Rv2073, and the NH2 part of cobL compared to its homolog in Mycobacterium tuberculosis strain H37Rv; hypothetical protein 2307282 7563110 JTY_2087 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645140.1 2306494 R 561275 CDS YP_002645141.1 224990454 7561258 complement(2307440..2307691) 1 NC_012207.1 hypothetical protein 2307691 7561258 JTY_2088 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645141.1 2307440 R 561275 CDS YP_002645142.1 224990455 7561259 complement(2307726..2308697) 1 NC_012207.1 transmembrane protein 2308697 7561259 JTY_2089 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645142.1 2307726 R 561275 CDS YP_002645143.1 224990456 7561260 complement(2308698..2308997) 1 NC_012207.1 hypothetical protein 2308997 7561260 JTY_2090 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645143.1 2308698 R 561275 CDS YP_002645144.1 224990457 7561261 2309462..2309776 1 NC_012207.1 Differs from Rv2078 by 1aa, G6E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2309776 7561261 JTY_2091 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645144.1 2309462 D 561275 CDS YP_002645145.1 224990458 7561262 2309758..2311728 1 NC_012207.1 Differs from Rv2079 by 2aa, C47Y, L216P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2311728 7561262 JTY_2092 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645145.1 2309758 D 561275 CDS YP_002645146.1 224990459 7561263 2311709..2312272 1 NC_012207.1 Differs from Rv2080 by 1aa, A23V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 2312272 lppJ 7561263 lppJ Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645146.1 2311709 D 561275 CDS YP_002645147.1 224990460 7560475 complement(2312468..2312914) 1 NC_012207.1 In Mycobacterium bovis BCG Tokyo, insertion 5bp or 2bp compared to its homologs in Mycobacterium tuberculosis strain H37Rv or Mycobacterium bovis leads to a product with different C-terminal part. 5bp:GGGGG insertion in BCG Tokyo after 311:G of Mycobacterium bovis or Mycobacterium tuberculosis H37Rv(Rv2081c), 11bp:GGGGGGGGGGG insertion in BCG Pasteur after 311:G of Mycobacterium tuberculosis H37Rv. In Mycobacterium bovis, a 3 bp in-frame insertion (*-GGG) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (147 aa versus 146 aa).; transmembrane protein 2312914 7560475 JTY_2094 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645147.1 2312468 R 561275 CDS YP_002645148.1 224990461 7561264 2313118..2315205 1 NC_012207.1 Differs from Mb2108 (721 aa) and from Rv2082 (721aa) by 26 codon in-frame deletion and from Rv2082 by 2aa, A183T, R612L in BCG Pasteur and BCG Tokyo; hypothetical protein 2315205 7561264 JTY_2095 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645148.1 2313118 D 561275 CDS YP_002645149.1 224990462 7561265 2315202..2316146 1 NC_012207.1 Differs from Rv2083 by 1aa, V256L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2316146 7561265 JTY_2096 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645149.1 2315202 D 561275 CDS YP_002645150.1 224990463 7561266 2316139..2317134 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2084 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo, a frameshift due to an 11bp insertion (*-GGCGTACACAC), splits Rv2084 into 2 parts; hypothetical protein 2317134 7561266 JTY_2097 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645150.1 2316139 D 561275 CDS YP_002645151.1 224990464 7561268 2317369..2317674 1 NC_012207.1 hypothetical protein 2317674 7561268 JTY_2099 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645151.1 2317369 D 561275 CDS YP_002645152.1 224990465 7561269 2317653..2318258 1 NC_012207.1 hypothetical protein 2318258 7561269 JTY_2100 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645152.1 2317653 D 561275 CDS YP_002645153.1 224990466 7561270 2318336..2318566 1 NC_012207.1 hypothetical protein 2318566 7561270 JTY_2101 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645153.1 2318336 D 561275 CDS YP_002645154.1 224990467 7561271 2318753..2320522 1 NC_012207.1 transmembrane serine/threonine-protein kinase J 2320522 pknJ 7561271 pknJ Mycobacterium bovis BCG str. Tokyo 172 transmembrane serine/threonine-protein kinase J YP_002645154.1 2318753 D 561275 CDS YP_002645155.1 224990468 7562437 complement(2320539..2321666) 1 NC_012207.1 dipeptidase 2321666 pepE 7562437 pepE Mycobacterium bovis BCG str. Tokyo 172 dipeptidase YP_002645155.1 2320539 R 561275 CDS YP_002645156.1 224990469 7561744 2321715..2322782 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 114 bp in-frame deletion leads to a shorter product compared to its ortholog in Mycobacterium tuberculosis strain H37Rv (355 aa versus 393 aa) and a 57 bp in-frame deletion leads to a shorter product compared to its ortholog in Mycobacterium bovis (355 aa versus 374 aa). Difference is due to copy number of tandem motif: DPTSGDPLHPAPPRLRSPL (or variant there of) near N-terminus. Also differs from Rv2090 by 1aa, L320F in BCG Pasteur and BCG Tokyo; 5'-3' exonuclease 2322782 7561744 JTY_2104 Mycobacterium bovis BCG str. Tokyo 172 5'-3' exonuclease YP_002645156.1 2321715 D 561275 CDS YP_002645157.1 224990470 7561272 complement(2322786..2323520) 1 NC_012207.1 hypothetical protein 2323520 7561272 JTY_2105 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645157.1 2322786 R 561275 CDS YP_002645158.1 224990471 7561273 complement(2323562..2326282) 1 NC_012207.1 Differs from Rv2092c by 1aa, M178T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; ATP-dependent DNA helicase 2326282 helY 7561273 helY Mycobacterium bovis BCG str. Tokyo 172 ATP-dependent DNA helicase YP_002645158.1 2323562 R 561275 CDS YP_002645159.1 224990472 7563295 complement(2326331..2327257) 1 NC_012207.1 sec-independent protein translocase transmembrane protein 2327257 tatC 7563295 tatC Mycobacterium bovis BCG str. Tokyo 172 sec-independent protein translocase transmembrane protein YP_002645159.1 2326331 R 561275 CDS YP_002645160.1 224990473 7561825 complement(2327274..2327525) 1 NC_012207.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 2327525 tatA 7561825 tatA Mycobacterium bovis BCG str. Tokyo 172 twin arginine translocase protein A YP_002645160.1 2327274 R 561275 CDS YP_002645161.1 224990474 7561823 complement(2327593..2328543) 1 NC_012207.1 Differs from Mb2122c by 1aa, A267V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2328543 7561823 JTY_2109 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645161.1 2327593 R 561275 CDS YP_002645162.1 224990475 7561274 complement(2328540..2329538) 1 NC_012207.1 hypothetical protein 2329538 7561274 JTY_2110 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645162.1 2328540 R 561275 CDS YP_002645163.1 224990476 7561275 complement(2329547..2330905) 1 NC_012207.1 hypothetical protein 2330905 7561275 JTY_2111 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645163.1 2329547 R 561275 CDS YP_002645164.1 224990477 7561276 complement(2330957..2332432) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS36 and PE21 exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base insertion (*-c) leads to a single product more similar to PE_PGRS36. There is also a 3 bp in-frame deletion (GGC-*); PE-PGRS family protein 2332432 PE_PGRS36 7561276 PE_PGRS36 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002645164.1 2330957 R 561275 CDS YP_002645165.1 224990478 7561780 2332615..2334267 1 NC_012207.1 hypothetical protein 2334267 7561780 JTY_2113 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645165.1 2332615 D 561275 CDS YP_002645166.1 224990479 7561277 2334466..2337507 1 NC_012207.1 Differs from Rv2101 by 3aa, L462M, Q601P, S652A in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; helicase 2337507 helZ 7561277 helZ Mycobacterium bovis BCG str. Tokyo 172 helicase YP_002645166.1 2334466 D 561275 CDS YP_002645167.1 224990480 7563296 2337617..2338333 1 NC_012207.1 hypothetical protein 2338333 7563296 JTY_2115 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645167.1 2337617 D 561275 CDS YP_002645168.1 224990481 7561278 complement(2338312..2338746) 1 NC_012207.1 hypothetical protein 2338746 7561278 JTY_2116 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645168.1 2338312 R 561275 CDS YP_002645169.1 224990482 7561279 complement(2338753..2339007) 1 NC_012207.1 hypothetical protein 2339007 7561279 JTY_2117 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645169.1 2338753 R 561275 CDS YP_002645170.1 224990483 7561280 2340227..2340523 1 NC_012207.1 PE family protein 2340523 PE22 7561280 PE22 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002645170.1 2340227 D 561275 CDS YP_002645171.1 224990484 7561722 2340579..2341310 1 NC_012207.1 PPE family protein 2341310 PPE36 7561722 PPE36 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002645171.1 2340579 D 561275 CDS YP_002645172.1 224990485 7562176 complement(2341850..2342596) 1 NC_012207.1 Differs from Rv2109c by 2aa, P135R, G182R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; proteasome subunit alpha 2342596 prcA 7562176 prcA Mycobacterium bovis BCG str. Tokyo 172 proteasome subunit alpha YP_002645172.1 2341850 R 561275 CDS YP_002645173.1 224990486 7560819 complement(2342593..2343468) 1 NC_012207.1 proteasome subunit beta 2343468 prcB 7560819 prcB Mycobacterium bovis BCG str. Tokyo 172 proteasome subunit beta YP_002645173.1 2342593 R 561275 CDS YP_002645174.1 224990487 7560820 complement(2343465..2343659) 1 NC_012207.1 hypothetical protein 2343659 7560820 JTY_2122 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645174.1 2343465 R 561275 CDS YP_002645175.1 224990488 7561281 complement(2343772..2345379) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 57 bp in-frame deletion at the NH2 part, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (535 aa versus 554 aa); hypothetical protein 2345379 7561281 JTY_2123 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645175.1 2343772 R 561275 CDS YP_002645176.1 224990489 7561282 2345440..2346633 1 NC_012207.1 Differs from Mb2137 by 1aa, S278L, and from Rv2113 by 1aa, P207T in BCG Pasteur and BCG Tokyo; integral membrane protein 2346633 7561282 JTY_2124 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002645176.1 2345440 D 561275 CDS YP_002645177.1 224990490 7561283 2346644..2347267 1 NC_012207.1 hypothetical protein 2347267 7561283 JTY_2125 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645177.1 2346644 D 561275 CDS YP_002645178.1 224990491 7561284 complement(2347271..2349100) 1 NC_012207.1 ATPase 2349100 7561284 JTY_2126 Mycobacterium bovis BCG str. Tokyo 172 ATPase YP_002645178.1 2347271 R 561275 CDS YP_002645179.1 224990492 7561285 2349381..2349950 1 NC_012207.1 lipoprotein 2349950 lppK 7561285 lppK Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645179.1 2349381 D 561275 CDS YP_002645180.1 224990493 7560476 2349958..2350251 1 NC_012207.1 hypothetical protein 2350251 7560476 JTY_2128 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645180.1 2349958 D 561275 CDS YP_002645181.1 224990494 7564333 complement(2350280..2351122) 1 NC_012207.1 RNA methyltransferase 2351122 7564333 JTY_2129 Mycobacterium bovis BCG str. Tokyo 172 RNA methyltransferase YP_002645181.1 2350280 R 561275 CDS YP_002645182.1 224990495 7564334 2351196..2352032 1 NC_012207.1 hypothetical protein 2352032 7564334 JTY_2130 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645182.1 2351196 D 561275 CDS YP_002645183.1 224990496 7564335 complement(2352055..2352537) 1 NC_012207.1 integral membrane protein 2352537 7564335 JTY_2131 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002645183.1 2352055 R 561275 CDS YP_002645184.1 224990497 7564336 complement(2352616..2353470) 1 NC_012207.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2353470 hisG 7564336 hisG Mycobacterium bovis BCG str. Tokyo 172 ATP phosphoribosyltransferase YP_002645184.1 2352616 R 561275 CDS YP_002645185.1 224990498 7563315 complement(2353473..2353754) 1 NC_012207.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase 2353754 hisE 7563315 hisE Mycobacterium bovis BCG str. Tokyo 172 phosphoribosyl-ATP pyrophosphatase YP_002645185.1 2353473 R 561275 CDS YP_002645186.1 224990499 7563313 2353881..2355275 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 27 bp in-frame deletion leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 473 aa); PPE family protein 2355275 PPE37 7563313 PPE37 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002645186.1 2353881 D 561275 CDS YP_002645187.1 224990500 7562177 complement(2355272..2358850) 1 NC_012207.1 Differs from Rv2124c by 1aa, V752I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methionine synthase, vitamin-B12 dependent isozyme, MS; 5-methyltetrahydrofolate--homocysteine methyltransferase 2358850 metH 7562177 metH Mycobacterium bovis BCG str. Tokyo 172 5-methyltetrahydrofolate--homocysteine methyltransferase YP_002645187.1 2355272 R 561275 CDS YP_002645188.1 224990501 7564461 2359076..2359954 1 NC_012207.1 Differs from Rv2125 by 1aa, S33G in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2359954 7564461 JTY_2136 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645188.1 2359076 D 561275 CDS YP_002645189.1 224990502 7564337 complement(2359985..2360755) 1 NC_012207.1 PE-PGRS family protein 2360755 PE_PGRS37 7564337 PE_PGRS37 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002645189.1 2359985 R 561275 CDS YP_002645190.1 224990503 7561781 2361399..2362868 1 NC_012207.1 Differs from Rv2127 by 2aa, D9G, S44G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; L-asparagine permease 2362868 ansP1 7561781 ansP1 Mycobacterium bovis BCG str. Tokyo 172 L-asparagine permease YP_002645190.1 2361399 D 561275 CDS YP_002645191.1 224990504 7563977 2362868..2363071 1 NC_012207.1 transmembrane protein 2363071 7563977 JTY_2139 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645191.1 2362868 D 561275 CDS YP_002645192.1 224990505 7564338 complement(2363091..2363972) 1 NC_012207.1 short chain dehydrogenase 2363972 7564338 JTY_2140 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002645192.1 2363091 R 561275 CDS YP_002645193.1 224990506 7564339 complement(2363998..2365242) 1 NC_012207.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 2365242 cysS2 7564339 cysS2 Mycobacterium bovis BCG str. Tokyo 172 cysteinyl-tRNA synthetase YP_002645193.1 2363998 R 561275 CDS YP_002645194.1 224990507 7561460 complement(2365300..2366103) 1 NC_012207.1 hypothetical protein 2366103 cysQ 7561460 cysQ Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645194.1 2365300 R 561275 CDS YP_002645195.1 224990508 7563182 2366194..2366424 1 NC_012207.1 hypothetical protein 2366424 7563182 JTY_2143 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645195.1 2366194 D 561275 CDS YP_002645196.1 224990509 7564340 complement(2366634..2367422) 1 NC_012207.1 hypothetical protein 2367422 7564340 JTY_2144 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645196.1 2366634 R 561275 CDS YP_002645197.1 224990510 7564341 complement(2367433..2368020) 1 NC_012207.1 hypothetical protein 2368020 7564341 JTY_2145 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645197.1 2367433 R 561275 CDS YP_002645198.1 224990511 7564342 complement(2368084..2368794) 1 NC_012207.1 hypothetical protein 2368794 7564342 JTY_2146 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645198.1 2368084 R 561275 CDS YP_002645199.1 224990512 7564343 complement(2368791..2369621) 1 NC_012207.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 2369621 7564343 JTY_2147 Mycobacterium bovis BCG str. Tokyo 172 UDP pyrophosphate phosphatase YP_002645199.1 2368791 R 561275 CDS YP_002645200.1 224990513 7564344 complement(2369685..2370098) 1 NC_012207.1 hypothetical protein 2370098 7564344 JTY_2148 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645200.1 2369685 R 561275 CDS YP_002645201.1 224990514 7564345 2370113..2371189 1 NC_012207.1 Differs from Mb2162 by 3aa, VQV348-350SRF, due to 7bp substitution in latter, tccaggt-gtccagg in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 2371189 lppL 7564345 lppL Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645201.1 2370113 D 561275 CDS YP_002645202.1 224990515 7560477 2371503..2372576 1 NC_012207.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 2372576 pyrD 7560477 pyrD Mycobacterium bovis BCG str. Tokyo 172 dihydroorotate dehydrogenase 2 YP_002645202.1 2371503 D 561275 CDS YP_002645203.1 224990516 7560872 complement(2372581..2373111) 1 NC_012207.1 hypothetical protein 2373111 TB18.6 7560872 TB18.6 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645203.1 2372581 R 561275 CDS YP_002645204.1 224990517 7561831 complement(2373159..2374505) 1 NC_012207.1 hypothetical protein 2374505 7561831 JTY_2152 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645204.1 2373159 R 561275 CDS YP_002645205.1 224990518 7562819 complement(2374976..2375293) 1 NC_012207.1 hypothetical protein 2375293 7562819 JTY_2153 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645205.1 2374976 R 561275 CDS YP_002645206.1 224990519 7564347 2375760..2376818 1 NC_012207.1 hypothetical protein 2376818 7564347 JTY_2154 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645206.1 2375760 D 561275 CDS YP_002645207.1 224990520 7564348 complement(2376948..2377304) 1 NC_012207.1 transmembrane protein 2377304 7564348 JTY_2155 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645207.1 2376948 R 561275 CDS YP_002645208.1 224990521 7564349 complement(2377399..2378181) 1 NC_012207.1 hypothetical protein 2378181 wag31 7564349 wag31 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645208.1 2377399 R 561275 CDS YP_002645209.1 224990522 7561685 complement(2378449..2378739) 1 NC_012207.1 transmembrane protein 2378739 7561685 JTY_2157 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645209.1 2378449 R 561275 CDS YP_002645210.1 224990523 7564350 complement(2378901..2379626) 1 NC_012207.1 hypothetical protein 2379626 7564350 JTY_2158 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645210.1 2378901 R 561275 CDS YP_002645211.1 224990524 7564351 complement(2379623..2380399) 1 NC_012207.1 hypothetical protein 2380399 7564351 JTY_2159 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645211.1 2379623 R 561275 CDS YP_002645212.1 224990525 7564352 complement(2380405..2381157) 1 NC_012207.1 hypothetical protein 2381157 yfiH 7564352 yfiH Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645212.1 2380405 R 561275 CDS YP_002645213.1 224990526 7561704 complement(2381168..2382307) 1 NC_012207.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 2382307 ftsZ 7561704 ftsZ Mycobacterium bovis BCG str. Tokyo 172 cell division protein FtsZ YP_002645213.1 2381168 R 561275 CDS YP_002645214.1 224990527 7561883 complement(2382480..2383424) 1 NC_012207.1 cell division protein 2383424 ftsQ 7561883 ftsQ Mycobacterium bovis BCG str. Tokyo 172 cell division protein YP_002645214.1 2382480 R 561275 CDS YP_002645215.1 224990528 7561879 complement(2383421..2384905) 1 NC_012207.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 2384905 murC 7561879 murC Mycobacterium bovis BCG str. Tokyo 172 UDP-N-acetylmuramate--L-alanine ligase YP_002645215.1 2383421 R 561275 CDS YP_002645216.1 224990529 7563573 complement(2384902..2386134) 1 NC_012207.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDP diphospho-muramoyl pentapeptide beta-N acetylglucosaminyl transferase 2386134 murG 7563573 murG Mycobacterium bovis BCG str. Tokyo 172 UDP diphospho-muramoyl pentapeptide beta-N acetylglucosaminyl transferase YP_002645216.1 2384902 R 561275 CDS YP_002645217.1 224990530 7563577 complement(2386034..2387704) 1 NC_012207.1 In Mycobacterium bovis BCG Tokyo, 1bp deletion at 1402:C of Mycobacterium tuberculosis, Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, leads to a shortly larger product compared with its homolog in Mycobacterium tuberculosis (Rv2154c), Mycobacterium bovis, and BCG Pasteur (553aa vs 524aa) and leads to product with different C-terminal part.; FtsW-like protein 2387704 ftsW 7563577 ftsW Mycobacterium bovis BCG str. Tokyo 172 FtsW-like protein YP_002645217.1 2386034 R 561275 CDS YP_002645218.1 224990531 7561880 complement(2387716..2389176) 1 NC_012207.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 2389176 murD 7561880 murD Mycobacterium bovis BCG str. Tokyo 172 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_002645218.1 2387716 R 561275 CDS YP_002645219.1 224990532 7563574 complement(2389178..2390257) 1 NC_012207.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 2390257 mraY 7563574 mraY Mycobacterium bovis BCG str. Tokyo 172 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_002645219.1 2389178 R 561275 CDS YP_002645220.1 224990533 7563559 complement(2390254..2391786) 1 NC_012207.1 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase 2391786 murF 7563559 murF Mycobacterium bovis BCG str. Tokyo 172 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase YP_002645220.1 2390254 R 561275 CDS YP_002645221.1 224990534 7563576 complement(2391783..2393390) 1 NC_012207.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 2393390 murE 7563576 murE Mycobacterium bovis BCG str. Tokyo 172 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_002645221.1 2391783 R 561275 CDS YP_002645222.1 224990535 7563575 complement(2393413..2394447) 1 NC_012207.1 hypothetical protein 2394447 7563575 JTY_2170 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645222.1 2393413 R 561275 CDS YP_002645223.1 224990536 7564353 complement(2394444..2395064) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2160A and Rv2160c exist as 2 genes with an overlap region between them. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 4 bp insertion (*-GGAA) leads to a single product; hypothetical protein 2395064 7564353 JTY_2171 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645223.1 2394444 R 561275 CDS YP_002645224.1 224990537 7564354 complement(2395057..2395923) 1 NC_012207.1 hypothetical protein 2395923 7564354 JTY_2172 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645224.1 2395057 R 561275 CDS YP_002645225.1 224990538 7564355 complement(2396026..2397498) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, in-frame deletions of 108 bp and 18 bp leads to a shorter product than in Mycobacterium tuberculosis strain H37Rv (490 aa versus 532 aa); PE-PGRS family protein 2397498 PE_PGRS38 7564355 PE_PGRS38 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002645225.1 2396026 R 561275 CDS YP_002645226.1 224990539 7561782 complement(2397708..2399747) 1 NC_012207.1 penicillin-binding membrane protein 2399747 pbpB 7561782 pbpB Mycobacterium bovis BCG str. Tokyo 172 penicillin-binding membrane protein YP_002645226.1 2397708 R 561275 CDS YP_002645227.1 224990540 7562519 complement(2399744..2400898) 1 NC_012207.1 Differs from Mb2188c by 1aa, V202A in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; proline rich membrane protein 2400898 7562519 JTY_2175 Mycobacterium bovis BCG str. Tokyo 172 proline rich membrane protein YP_002645227.1 2399744 R 561275 CDS YP_002645228.1 224990541 7564356 complement(2400895..2402085) 1 NC_012207.1 S-adenosyl-methyltransferase MraW 2402085 mraW 7564356 mraW Mycobacterium bovis BCG str. Tokyo 172 S-adenosyl-methyltransferase MraW YP_002645228.1 2400895 R 561275 CDS YP_002645229.1 224990542 7563558 complement(2402087..2402518) 1 NC_012207.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 2402518 7563558 JTY_2177 Mycobacterium bovis BCG str. Tokyo 172 cell division protein MraZ YP_002645229.1 2402087 R 561275 CDS YP_002645230.1 224990543 7564357 complement(2402867..2403271) 1 NC_012207.1 transmembrane protein 2403271 7564357 JTY_2178 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645230.1 2402867 R 561275 CDS YP_002645231.1 224990544 7564358 2403537..2404157 1 NC_012207.1 hypothetical protein 2404157 7564358 JTY_2179 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645231.1 2403537 D 561275 CDS YP_002645232.1 224990545 7564359 2404253..2404936 1 NC_012207.1 lipoprotein 2404936 lppM 7564359 lppM Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645232.1 2404253 D 561275 CDS YP_002645233.1 224990546 7560478 complement(2404933..2405838) 1 NC_012207.1 hypothetical protein 2405838 7560478 JTY_2181 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645233.1 2404933 R 561275 CDS YP_002645234.1 224990547 7564360 2406149..2407207 1 NC_012207.1 geranylgeranyl pyrophosphate synthetase 2407207 idsA2 7564360 idsA2 Mycobacterium bovis BCG str. Tokyo 172 geranylgeranyl pyrophosphate synthetase YP_002645234.1 2406149 D 561275 CDS YP_002645235.1 224990548 7563345 2407211..2408914 1 NC_012207.1 Differs from Rv2174 and Mb2196 at 3'-end owing to frameshift due to 1 bp insertion (T) at position corresponding to H37Rv coordinates 2437401-2437402, and from Rv2174 by 1aa, S451A in BCG Pasteur and BCG Tokyo; transmembrane protein 2408914 7563345 JTY_2183 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645235.1 2407211 D 561275 CDS YP_002645236.1 224990549 7564361 complement(2408749..2409189) 1 NC_012207.1 Differs from Rv2175c by 1aa, L17P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical regulatory protein 2409189 7564361 JTY_2184 Mycobacterium bovis BCG str. Tokyo 172 hypothetical regulatory protein YP_002645236.1 2408749 R 561275 CDS YP_002645237.1 224990550 7564362 2409244..2410443 1 NC_012207.1 Differs from Rv2176 by 1aa, A52S in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; transmembrane serine/threonine-protein kinase L 2410443 pknL 7564362 pknL Mycobacterium bovis BCG str. Tokyo 172 transmembrane serine/threonine-protein kinase L YP_002645237.1 2409244 D 561275 CDS YP_002645238.1 224990551 7562439 complement(2410585..2411250) 1 NC_012207.1 Differs from Rv2177c by 1aa, K115T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transposase 2411250 7562439 JTY_2186 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002645238.1 2410585 R 561275 CDS YP_002645239.1 224990552 7564363 complement(2411635..2413023) 1 NC_012207.1 Differs from Rv2178c by 1aa, E265D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; 3-deoxy-D-arabino-heptulosonate7- phosphate synthase 2413023 aroG 7564363 aroG Mycobacterium bovis BCG str. Tokyo 172 3-deoxy-D-arabino-heptulosonate7- phosphate synthase YP_002645239.1 2411635 R 561275 CDS YP_002645240.1 224990553 7564001 complement(2413114..2413620) 1 NC_012207.1 hypothetical protein 2413620 7564001 JTY_2188 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645240.1 2413114 R 561275 CDS YP_002645241.1 224990554 7564364 complement(2413630..2414517) 1 NC_012207.1 Differs from Rv2180c by 1aa, T156P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein 2414517 7564364 JTY_2189 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002645241.1 2413630 R 561275 CDS YP_002645242.1 224990555 7564365 2414605..2415888 1 NC_012207.1 integral membrane protein 2415888 7564365 JTY_2190 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002645242.1 2414605 D 561275 CDS YP_002645243.1 224990556 7564366 complement(2415889..2416632) 1 NC_012207.1 1-acylglycerol-3-phosphate O-acyltransferase 2416632 7564366 JTY_2191 Mycobacterium bovis BCG str. Tokyo 172 1-acylglycerol-3-phosphate O-acyltransferase YP_002645243.1 2415889 R 561275 CDS YP_002645244.1 224990557 7564367 complement(2416718..2417113) 1 NC_012207.1 hypothetical protein 2417113 7564367 JTY_2192 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645244.1 2416718 R 561275 CDS YP_002645245.1 224990558 7564368 complement(2417110..2418249) 1 NC_012207.1 hypothetical protein 2418249 7564368 JTY_2193 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645245.1 2417110 R 561275 CDS YP_002645246.1 224990559 7564369 complement(2418369..2418803) 1 NC_012207.1 hypothetical protein 2418803 TB16.3 7564369 TB16.3 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645246.1 2418369 R 561275 CDS YP_002645247.1 224990560 7561829 complement(2418908..2419297) 1 NC_012207.1 hypothetical protein 2419297 7561829 JTY_2195 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645247.1 2418908 R 561275 CDS YP_002645248.1 224990561 7564370 2419463..2419975 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, fadD15 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to single base deletion (T-*) splits fadD15 into 2 parts.; hypothetical protein 2419975 7564370 JTY_2196 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645248.1 2419463 D 561275 CDS YP_002645249.1 224990562 7564371 2419738..2421264 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, fadD15 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to single base deletion (T-*) splits fadD15 into 2 parts. Differs from Rv2187 by 2aa, I8T, E287G in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; long-chain-fatty-acid-CoA ligase 2421264 fadD15 7564371 fadD15 Mycobacterium bovis BCG str. Tokyo 172 long-chain-fatty-acid-CoA ligase YP_002645249.1 2419738 D 561275 CDS YP_002645250.1 224990563 7562921 complement(2421295..2422452) 1 NC_012207.1 hypothetical protein 2422452 7562921 JTY_2198 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645250.1 2421295 R 561275 CDS YP_002645251.1 224990564 7564372 complement(2422549..2423322) 1 NC_012207.1 hypothetical protein 2423322 7564372 JTY_2199 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645251.1 2422549 R 561275 CDS YP_002645252.1 224990565 7564373 complement(2423417..2424574) 1 NC_012207.1 hypothetical protein 2424574 7564373 JTY_2200 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645252.1 2423417 R 561275 CDS YP_002645253.1 224990566 7564374 2425121..2427058 1 NC_012207.1 contains 3'-5'exonuclease domain; hypothetical protein 2427058 7564374 JTY_2201 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645253.1 2425121 D 561275 CDS YP_002645254.1 224990567 7564375 complement(2426933..2428045) 1 NC_012207.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 2428045 trpD 7564375 trpD Mycobacterium bovis BCG str. Tokyo 172 anthranilate phosphoribosyltransferase YP_002645254.1 2426933 R 561275 CDS YP_002645255.1 224990568 7561631 2428203..2428814 1 NC_012207.1 cytochrome c oxidase subunit III 2428814 ctaE 7561631 ctaE Mycobacterium bovis BCG str. Tokyo 172 cytochrome c oxidase subunit III YP_002645255.1 2428203 D 561275 CDS YP_002645256.1 224990569 7563130 2428855..2429697 1 NC_012207.1 cytochrome c subunit; ubiquinol-cytochrome c reductase 2429697 qcrC 7563130 qcrC Mycobacterium bovis BCG str. Tokyo 172 ubiquinol-cytochrome c reductase YP_002645256.1 2428855 D 561275 CDS YP_002645257.1 224990570 7561547 2429694..2430983 1 NC_012207.1 Differs from Rv2195 by 1aa, I281M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; Rieske iron-sulfur protein 2430983 qcrA 7561547 qcrA Mycobacterium bovis BCG str. Tokyo 172 Rieske iron-sulfur protein YP_002645257.1 2429694 D 561275 CDS YP_002645258.1 224990571 7561545 2430980..2432629 1 NC_012207.1 cytochrome b subunit; ubiquinol-cytochrome c reductase 2432629 qcrB 7561545 qcrB Mycobacterium bovis BCG str. Tokyo 172 ubiquinol-cytochrome c reductase YP_002645258.1 2430980 D 561275 CDS YP_002645259.1 224990572 7561546 complement(2432920..2433564) 1 NC_012207.1 Differs from Rv2197c by 1aa, S202A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 2433564 7561546 JTY_2207 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645259.1 2432920 R 561275 CDS YP_002645260.1 224990573 7564376 complement(2433564..2434463) 1 NC_012207.1 hypothetical protein 2434463 mmpS3 7564376 mmpS3 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645260.1 2433564 R 561275 CDS YP_002645261.1 224990574 7563513 complement(2434649..2435068) 1 NC_012207.1 transmembrane protein 2435068 7563513 JTY_2209 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645261.1 2434649 R 561275 CDS YP_002645262.1 224990575 7564377 complement(2435076..2436167) 1 NC_012207.1 transmembrane cytochrome c oxidase subunit II 2436167 ctaC 7564377 ctaC Mycobacterium bovis BCG str. Tokyo 172 transmembrane cytochrome c oxidase subunit II YP_002645262.1 2435076 R 561275 CDS YP_002645263.1 224990576 7563128 2436413..2438371 1 NC_012207.1 asparagine synthetase 2438371 asnB 7563128 asnB Mycobacterium bovis BCG str. Tokyo 172 asparagine synthetase YP_002645263.1 2436413 D 561275 CDS YP_002645264.1 224990577 7562041 complement(2438469..2439443) 1 NC_012207.1 adenosine kinase 2439443 adoK 7562041 adoK Mycobacterium bovis BCG str. Tokyo 172 adenosine kinase YP_002645264.1 2438469 R 561275 CDS YP_002645265.1 224990578 7563948 2439647..2440339 1 NC_012207.1 hypothetical protein 2440339 7563948 JTY_2213 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645265.1 2439647 D 561275 CDS YP_002645266.1 224990579 7564378 complement(2440347..2440703) 1 NC_012207.1 hypothetical protein 2440703 7564378 JTY_2214 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645266.1 2440347 R 561275 CDS YP_002645267.1 224990580 7564379 complement(2440803..2441879) 1 NC_012207.1 hypothetical protein 2441879 7564379 JTY_2215 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645267.1 2440803 R 561275 CDS YP_002645268.1 224990581 7564380 2442038..2442748 1 NC_012207.1 transmembrane protein 2442748 7564380 JTY_2216 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645268.1 2442038 D 561275 CDS YP_002645269.1 224990582 7564381 2442827..2443912 1 NC_012207.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2443912 cobT 7564381 cobT Mycobacterium bovis BCG str. Tokyo 172 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase YP_002645269.1 2442827 D 561275 CDS YP_002645270.1 224990583 7563118 2443909..2444658 1 NC_012207.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 2444658 cobS 7563118 cobS Mycobacterium bovis BCG str. Tokyo 172 cobalamin synthase YP_002645270.1 2443909 D 561275 CDS YP_002645271.1 224990584 7563117 2444816..2446354 1 NC_012207.1 integral membrane protein 2446354 7563117 JTY_2219 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002645271.1 2444816 D 561275 CDS YP_002645272.1 224990585 7564382 complement(2446280..2447386) 1 NC_012207.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 2447386 ilvE 7564382 ilvE Mycobacterium bovis BCG str. Tokyo 172 branched-chain amino acid aminotransferase YP_002645272.1 2446280 R 561275 CDS YP_002645273.1 224990586 7562780 complement(2447458..2448597) 1 NC_012207.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 2448597 gcvT 7562780 gcvT Mycobacterium bovis BCG str. Tokyo 172 glycine cleavage system aminomethyltransferase T YP_002645273.1 2447458 R 561275 CDS YP_002645274.1 224990587 7561911 2448606..2449742 1 NC_012207.1 hypothetical protein 2449742 7561911 JTY_2222 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645274.1 2448606 D 561275 CDS YP_002645275.1 224990588 7564383 2449754..2451301 1 NC_012207.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 2451301 pepB 7564383 pepB Mycobacterium bovis BCG str. Tokyo 172 leucyl aminopeptidase YP_002645275.1 2449754 D 561275 CDS YP_002645276.1 224990589 7561742 complement(2451339..2453117) 1 NC_012207.1 short chain dehydrogenase 2453117 ephD 7561742 ephD Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002645276.1 2451339 R 561275 CDS YP_002645277.1 224990590 7562869 2453381..2455042 1 NC_012207.1 Differs from Rv2215 and Mb2238 by 1aa, V517L in BCG Pasteur and BCG Tokyo; dihydrolipoamide acetyltransferase 2455042 dlaT 7562869 dlaT Mycobacterium bovis BCG str. Tokyo 172 dihydrolipoamide acetyltransferase YP_002645277.1 2453381 D 561275 CDS YP_002645278.1 224990591 7561498 2455042..2455947 1 NC_012207.1 hypothetical protein 2455947 7561498 JTY_2226 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645278.1 2455042 D 561275 CDS YP_002645279.1 224990592 7564384 2456000..2456692 1 NC_012207.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 2456692 lipB 7564384 lipB Mycobacterium bovis BCG str. Tokyo 172 lipoate-protein ligase B YP_002645279.1 2456000 D 561275 CDS YP_002645280.1 224990593 7562830 2456689..2457624 1 NC_012207.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 2457624 lipA 7562830 lipA Mycobacterium bovis BCG str. Tokyo 172 lipoyl synthase YP_002645280.1 2456689 D 561275 CDS YP_002645281.1 224990594 7562829 2457651..2458403 1 NC_012207.1 Differs from Rv2219 by 1aa, L74F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 2458403 7562829 JTY_2229 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645281.1 2457651 D 561275 CDS YP_002645282.1 224990595 7564385 complement(2458410..2458832) 1 NC_012207.1 hypothetical protein 2458832 7564385 JTY_2230 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645282.1 2458410 R 561275 CDS YP_002645283.1 224990596 7564386 2459031..2460467 1 NC_012207.1 glutamine synthetase 2460467 glnA1 7564386 glnA1 Mycobacterium bovis BCG str. Tokyo 172 glutamine synthetase YP_002645283.1 2459031 D 561275 CDS YP_002645284.1 224990597 7561926 complement(2460785..2463769) 1 NC_012207.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 2463769 glnE 7561926 glnE Mycobacterium bovis BCG str. Tokyo 172 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_002645284.1 2460785 R 561275 CDS YP_002645285.1 224990598 7561932 complement(2463818..2465158) 1 NC_012207.1 glutamine synthetase 2465158 glnA2 7561932 glnA2 Mycobacterium bovis BCG str. Tokyo 172 glutamine synthetase YP_002645285.1 2463818 R 561275 CDS YP_002645286.1 224990599 7561927 complement(2465253..2466815) 1 NC_012207.1 Differs from Rv2223c and Mb2247c by 1aa, S307A in BCG Pasteur and BCG Tokyo; exported protease 2466815 7561927 JTY_2234 Mycobacterium bovis BCG str. Tokyo 172 exported protease YP_002645286.1 2465253 R 561275 CDS YP_002645287.1 224990600 7564387 complement(2466877..2468439) 1 NC_012207.1 exported protease 2468439 7564387 JTY_2235 Mycobacterium bovis BCG str. Tokyo 172 exported protease YP_002645287.1 2466877 R 561275 CDS YP_002645288.1 224990601 7564388 2469158..2470003 1 NC_012207.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 2470003 panB 7564388 panB Mycobacterium bovis BCG str. Tokyo 172 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_002645288.1 2469158 D 561275 CDS YP_002645289.1 224990602 7562508 2470248..2471789 1 NC_012207.1 Differs from Rv2226 and Mb2250 by 1aa, N299D andG31D, respectively, in BCG Pasteur and BCG Tokyo; hypothetical protein 2471789 7562508 JTY_2237 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645289.1 2470248 D 561275 CDS YP_002645290.1 224990603 7564320 2472347..2472667 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2227 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 1bp to 2bp substitution (T-CC) splits Rv2227 in two parts; hypothetical protein 2472667 7564320 JTY_2238 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645290.1 2472347 D 561275 CDS YP_002645291.1 224990604 7564390 2472675..2473049 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2227 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 1bp to 2bp substitution (T-CC) splits Rv2227 in two parts; hypothetical protein 2473049 7564390 JTY_2239 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645291.1 2472675 D 561275 CDS YP_002645292.1 224990605 7564391 complement(2473061..2474155) 1 NC_012207.1 bifunctional RNase H/acid phosphatase 2474155 7564391 JTY_2240 Mycobacterium bovis BCG str. Tokyo 172 bifunctional RNase H/acid phosphatase YP_002645292.1 2473061 R 561275 CDS YP_002645293.1 224990606 7564392 complement(2474152..2474889) 1 NC_012207.1 Differs from Rv2229c by 1aa, Q239R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2474889 7564392 JTY_2241 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645293.1 2474152 R 561275 CDS YP_002645294.1 224990607 7564393 complement(2474886..2476025) 1 NC_012207.1 hypothetical protein 2476025 7564393 JTY_2242 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645294.1 2474886 R 561275 CDS YP_002645295.1 224990608 7564394 complement(2476022..2477116) 1 NC_012207.1 hypothetical protein 2477116 cobC 7564394 cobC Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645295.1 2476022 R 561275 CDS YP_002645296.1 224990609 7563104 2477695..2478570 1 NC_012207.1 hypothetical protein 2478570 7563104 JTY_2244 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645296.1 2477695 D 561275 CDS YP_002645297.1 224990610 7564395 2478563..2479054 1 NC_012207.1 phosphotyrosine protein phosphatase 2479054 ptpA 7564395 ptpA Mycobacterium bovis BCG str. Tokyo 172 phosphotyrosine protein phosphatase YP_002645297.1 2478563 D 561275 CDS YP_002645298.1 224990611 7560852 2479054..2479869 1 NC_012207.1 transmembrane protein 2479869 7560852 JTY_2246 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645298.1 2479054 D 561275 CDS YP_002645299.1 224990612 7564396 complement(2479851..2480792) 1 NC_012207.1 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group; cobalamin biosynthesis protein 2480792 cobD 7564396 cobD Mycobacterium bovis BCG str. Tokyo 172 cobalamin biosynthesis protein YP_002645299.1 2479851 R 561275 CDS YP_002645300.1 224990613 7563105 2480906..2481673 1 NC_012207.1 hypothetical protein 2481673 7563105 JTY_2248 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645300.1 2480906 D 561275 CDS YP_002645301.1 224990614 7561680 complement(2482132..2482593) 1 NC_012207.1 peroxiredoxin 2482593 ahpE 7561680 ahpE Mycobacterium bovis BCG str. Tokyo 172 peroxiredoxin YP_002645301.1 2482132 R 561275 CDS YP_002645302.1 224990615 7563953 complement(2482593..2483069) 1 NC_012207.1 hypothetical protein 2483069 7563953 JTY_2250 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645302.1 2482593 R 561275 CDS YP_002645303.1 224990616 7564398 complement(2483107..2483904) 1 NC_012207.1 Differs from Rv2240c by 1aa, K259T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2483904 7564398 JTY_2251 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645303.1 2483107 R 561275 CDS YP_002645304.1 224990617 7564399 2483956..2486661 1 NC_012207.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 2486661 aceE 7564399 aceE Mycobacterium bovis BCG str. Tokyo 172 pyruvate dehydrogenase subunit E1 YP_002645304.1 2483956 D 561275 CDS YP_002645305.1 224990618 7563928 2486721..2487965 1 NC_012207.1 Differs from Rv2242 and Mb2266 by 1aa, T363A in BCG Pasteur and BCG Tokyo; hypothetical protein 2487965 7563928 JTY_2253 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645305.1 2486721 D 561275 CDS YP_002645306.1 224990619 7564400 2488204..2489112 1 NC_012207.1 malonyl CoA-acyl carrier protein transacylase 2489112 fabD 7564400 fabD Mycobacterium bovis BCG str. Tokyo 172 malonyl CoA-acyl carrier protein transacylase YP_002645306.1 2488204 D 561275 CDS YP_002645307.1 224990620 7562894 2489188..2489535 1 NC_012207.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 2489535 acpP 7562894 acpP Mycobacterium bovis BCG str. Tokyo 172 acyl carrier protein YP_002645307.1 2489188 D 561275 CDS YP_002645308.1 224990621 7563932 2489532..2490782 1 NC_012207.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 2490782 kasA 7563932 kasA Mycobacterium bovis BCG str. Tokyo 172 3-oxoacyl-ACP synthase YP_002645308.1 2489532 D 561275 CDS YP_002645309.1 224990622 7562798 2490813..2492129 1 NC_012207.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 2492129 kasB 7562798 kasB Mycobacterium bovis BCG str. Tokyo 172 3-oxoacyl-ACP synthase YP_002645309.1 2490813 D 561275 CDS YP_002645310.1 224990623 7562799 2492160..2493581 1 NC_012207.1 acetyl/propionyl-CoA carboxylase subunit beta 2493581 accD6 7562799 accD6 Mycobacterium bovis BCG str. Tokyo 172 acetyl/propionyl-CoA carboxylase subunit beta YP_002645310.1 2492160 D 561275 CDS YP_002645311.1 224990624 7563926 2493689..2494093 1 NC_012207.1 In Mycobacterium bovis and Mycobacterium tuberculosis, Rv2248 and Mb2272 exist as single gene. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, the ortholog is split into two parts owing to single base insertion in G-string (-G) at position equivalent to Mycobacterium tuberculosis position 2522481-2522482; hypothetical protein 2494093 7563926 JTY_2259 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645311.1 2493689 D 561275 CDS YP_002645312.1 224990625 7564401 2493801..2494505 1 NC_012207.1 In Mycobacterium bovis and Mycobacterium tuberculosis, Rv2248 and Mb2272 exist as single gene. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, the ortholog is split into two parts owing to single base insertion in G-string (-G) at position equivalent to Mycobacterium tuberculosis position 2522481-2522482; hypothetical protein 2494505 7564401 JTY_2260 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645312.1 2493801 D 561275 CDS YP_002645313.1 224990626 7564402 complement(2494574..2496124) 1 NC_012207.1 glycerol-3-phosphate dehydrogenase 2496124 glpD1 7564402 glpD1 Mycobacterium bovis BCG str. Tokyo 172 glycerol-3-phosphate dehydrogenase YP_002645313.1 2494574 R 561275 CDS YP_002645314.1 224990627 7561937 complement(2496118..2496687) 1 NC_012207.1 Differs from Mb2274c by 1aa, D68A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional regulatory protein 2496687 7561937 JTY_2262 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645314.1 2496118 R 561275 CDS YP_002645315.1 224990628 7564403 2496735..2498324 1 NC_012207.1 In Mycobacterium tuberculosis H37Rv, Rv2250A and Rv2251 exist as 2 genes with an overlap region between them. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base deletion (G-*) leads to a single product; flavoprotein 2498324 7564403 JTY_2263 Mycobacterium bovis BCG str. Tokyo 172 flavoprotein YP_002645315.1 2496735 D 561275 CDS YP_002645316.1 224990629 7564404 2498321..2499250 1 NC_012207.1 involved in the biosynthesis of phosphatidylinositol mannosides (PIMs); the enzyme from Mycobacterium tuberculosis can phosphorylate a variety of amphipathic lipids; diacylglycerol kinase 2499250 7564404 JTY_2264 Mycobacterium bovis BCG str. Tokyo 172 diacylglycerol kinase YP_002645316.1 2498321 D 561275 CDS YP_002645317.1 224990630 7564405 2499316..2499819 1 NC_012207.1 hypothetical protein 2499819 7564405 JTY_2265 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645317.1 2499316 D 561275 CDS YP_002645318.1 224990631 7564406 complement(2499852..2500307) 1 NC_012207.1 Differs from Rv2254c by 1aa, V68A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein 2500307 7564406 JTY_2266 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002645318.1 2499852 R 561275 CDS YP_002645319.1 224990632 7564407 complement(2500312..2500506) 1 NC_012207.1 hypothetical protein 2500506 7564407 JTY_2267 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645319.1 2500312 R 561275 CDS YP_002645320.1 224990633 7564408 complement(2500673..2501206) 1 NC_012207.1 Differs from Rv2256c by 1aa, G26A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2501206 7564408 JTY_2268 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645320.1 2500673 R 561275 CDS YP_002645321.1 224990634 7564409 complement(2501336..2502154) 1 NC_012207.1 hypothetical protein 2502154 7564409 JTY_2269 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645321.1 2501336 R 561275 CDS YP_002645322.1 224990635 7564410 complement(2502168..2503229) 1 NC_012207.1 transcriptional regulatory protein 2503229 7564410 JTY_2270 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645322.1 2502168 R 561275 CDS YP_002645323.1 224990636 7564411 2503471..2504556 1 NC_012207.1 zinc-dependent alcohol dehydrogenase 2504556 adhE2 7564411 adhE2 Mycobacterium bovis BCG str. Tokyo 172 zinc-dependent alcohol dehydrogenase YP_002645323.1 2503471 D 561275 CDS YP_002645324.1 224990637 7563946 2504556..2505191 1 NC_012207.1 hypothetical protein 2505191 7563946 JTY_2272 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645324.1 2504556 D 561275 CDS YP_002645325.1 224990638 7564412 complement(2505268..2506776) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2262cand Rv2261c exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 2 bp deletion (CT-*) results in a single product; hypothetical protein 2506776 7564412 JTY_2273 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645325.1 2505268 R 561275 CDS YP_002645326.1 224990639 7564413 2506865..2507818 1 NC_012207.1 short chain dehydrogenase 2507818 7564413 JTY_2274 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002645326.1 2506865 D 561275 CDS YP_002645327.1 224990640 7564414 complement(2507796..2509574) 1 NC_012207.1 hypothetical protein 2509574 7564414 JTY_2275 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645327.1 2507796 R 561275 CDS YP_002645328.1 224990641 7562938 2509924..2511153 1 NC_012207.1 transmembrane protein 2511153 7562938 JTY_2276 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645328.1 2509924 D 561275 CDS YP_002645329.1 224990642 7562939 2511328..2512614 1 NC_012207.1 cytochrome P450 124 2512614 cyp124 7562939 cyp124 Mycobacterium bovis BCG str. Tokyo 172 cytochrome P450 124 YP_002645329.1 2511328 D 561275 CDS YP_002645330.1 224990643 7563155 complement(2512868..2514034) 1 NC_012207.1 hypothetical protein 2514034 7563155 JTY_2278 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645330.1 2512868 R 561275 CDS YP_002645331.1 224990644 7562940 complement(2514031..2515500) 1 NC_012207.1 Differs from Rv2268c and Mb2291c by 1aa, F203L in BCG Pasteur and BCG Tokyo; cytochrome P450 128 2515500 cyp128 7562940 cyp128 Mycobacterium bovis BCG str. Tokyo 172 cytochrome P450 128 YP_002645331.1 2514031 R 561275 CDS YP_002645332.1 224990645 7563158 complement(2515513..2515845) 1 NC_012207.1 hypothetical protein 2515845 7563158 JTY_2280 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645332.1 2515513 R 561275 CDS YP_002645333.1 224990646 7562941 2515922..2516449 1 NC_012207.1 Differs from Mb2293 by 1aa, P152L in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 2516449 lppN 7562941 lppN Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645333.1 2515922 D 561275 CDS YP_002645334.1 224990647 7560479 2516556..2516855 1 NC_012207.1 hypothetical protein 2516855 7560479 JTY_2282 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645334.1 2516556 D 561275 CDS YP_002645335.1 224990648 7562942 2516961..2517329 1 NC_012207.1 hypothetical protein 2517329 7562942 JTY_2283 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645335.1 2516961 D 561275 CDS YP_002645336.1 224990649 7562943 2517326..2517655 1 NC_012207.1 transmembrane protein 2517655 7562943 JTY_2284 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645336.1 2517326 D 561275 CDS YP_002645337.1 224990650 7562944 complement(2517712..2518029) 1 NC_012207.1 Differs from Rv2274c by 1aa, M33I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2518029 7562944 JTY_2285 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645337.1 2517712 R 561275 CDS YP_002645338.1 224990651 7562945 2518107..2518976 1 NC_012207.1 Differs from Rv2275 and Mb2298 by 1aa, A261E in BCG Pasteur and BCG Tokyo; hypothetical protein 2518976 7562945 JTY_2286 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645338.1 2518107 D 561275 CDS YP_002645339.1 224990652 7562946 2518973..2520163 1 NC_012207.1 cytochrome P450 121 2520163 cyp121 7562946 cyp121 Mycobacterium bovis BCG str. Tokyo 172 cytochrome P450 121 YP_002645339.1 2518973 D 561275 CDS YP_002645340.1 224990653 7563153 complement(2520348..2521247) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 1358 bp deletion containing an IS6110 sequence, disrupts the 5' start of Rv2277c resulting in a slightly shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (299 aa versus 301 aa). Differs from Mb2300c by 1aa in BCG Pasteur and BCG Tokyo; glycerolphosphodiesterase 2521247 7563153 JTY_2288 Mycobacterium bovis BCG str. Tokyo 172 glycerolphosphodiesterase YP_002645340.1 2520348 R 561275 CDS YP_002645341.1 224990654 7562947 2521426..2522805 1 NC_012207.1 dehydrogenase 2522805 7562947 JTY_2289 Mycobacterium bovis BCG str. Tokyo 172 dehydrogenase YP_002645341.1 2521426 D 561275 CDS YP_002645342.1 224990655 7562948 2523039..2524697 1 NC_012207.1 phosphate-transport permease 2524697 pitB 7562948 pitB Mycobacterium bovis BCG str. Tokyo 172 phosphate-transport permease YP_002645342.1 2523039 D 561275 CDS YP_002645343.1 224990656 7562427 complement(2524804..2525742) 1 NC_012207.1 LysR-family; transcription regulator 2525742 7562427 JTY_2291 Mycobacterium bovis BCG str. Tokyo 172 transcription regulator YP_002645343.1 2524804 R 561275 CDS YP_002645344.1 224990657 7562949 2525807..2526001 1 NC_012207.1 hypothetical protein 2526001 7562949 JTY_2292 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645344.1 2525807 D 561275 CDS YP_002645345.1 224990658 7562950 2526011..2527306 1 NC_012207.1 esterase 2527306 lipM 7562950 lipM Mycobacterium bovis BCG str. Tokyo 172 esterase YP_002645345.1 2526011 D 561275 CDS YP_002645346.1 224990659 7562840 2527339..2528676 1 NC_012207.1 hypothetical protein 2528676 7562840 JTY_2294 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645346.1 2527339 D 561275 CDS YP_002645347.1 224990660 7562951 complement(2528743..2529006) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2286c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, an in-frame stop codon due to a single base transition (C-T) splits Rv2286c into 2 parts; hypothetical protein 2529006 7562951 JTY_2295 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645347.1 2528743 R 561275 CDS YP_002645348.1 224990661 7562952 complement(2529034..2529435) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2286c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, an in-frame stop codon due to a single base transition (C-T) splits Rv2286c into 2 parts; hypothetical protein 2529435 7562952 JTY_2296 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645348.1 2529034 R 561275 CDS YP_002645349.1 224990662 7562953 2529569..2531197 1 NC_012207.1 integral membrane transport protein 2531197 yjcE 7562953 yjcE Mycobacterium bovis BCG str. Tokyo 172 integral membrane transport protein YP_002645349.1 2529569 D 561275 CDS YP_002645350.1 224990663 7561705 2531194..2531571 1 NC_012207.1 hypothetical protein 2531571 7561705 JTY_2298 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645350.1 2531194 D 561275 CDS YP_002645351.1 224990664 7562954 2531541..2532323 1 NC_012207.1 CDP-diacylglycerol pyrophosphatase 2532323 cdh 7562954 cdh Mycobacterium bovis BCG str. Tokyo 172 CDP-diacylglycerol pyrophosphatase YP_002645351.1 2531541 D 561275 CDS YP_002645352.1 224990665 7562090 2532465..2532620 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2290 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*), splits lppO into 2 parts, lppOa and lppOb; lipoprotein 2532620 lppOa 7562090 lppOa Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645352.1 2532465 D 561275 CDS YP_002645353.1 224990666 7560480 2532614..2532979 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2290 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*), splits lppO into 2 parts, lppOa and lppOb; lipoprotein 2532979 lppOb 7560480 lppOb Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645353.1 2532614 D 561275 CDS YP_002645354.1 224990667 7560481 2533039..2533893 1 NC_012207.1 In Mycobacterium bovis, truncation at the 5' start due to a 2 bp deletion (TG-*), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (256 aa versus 284 aa). Differs from Rv2291 by 1aa, A262E; thiosulfate sulfurtransferase 2533893 sseB 7560481 sseB Mycobacterium bovis BCG str. Tokyo 172 thiosulfate sulfurtransferase YP_002645354.1 2533039 D 561275 CDS YP_002645355.1 224990668 7561809 complement(2533894..2534898) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2293c and Rv2292c exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base insertion (*-G) results in a single product; hypothetical protein 2534898 7561809 JTY_2303 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645355.1 2533894 R 561275 CDS YP_002645356.1 224990669 7562955 2535193..2536416 1 NC_012207.1 aminotransferase 2536416 7562955 JTY_2304 Mycobacterium bovis BCG str. Tokyo 172 aminotransferase YP_002645356.1 2535193 D 561275 CDS YP_002645357.1 224990670 7562956 2536639..2537277 1 NC_012207.1 hypothetical protein 2537277 7562956 JTY_2305 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645357.1 2536639 D 561275 CDS YP_002645358.1 224990671 7562957 2537371..2538273 1 NC_012207.1 haloalkane dehalogenase 2538273 7562957 JTY_2306 Mycobacterium bovis BCG str. Tokyo 172 haloalkane dehalogenase YP_002645358.1 2537371 D 561275 CDS YP_002645359.1 224990672 7562958 2538305..2538757 1 NC_012207.1 hypothetical protein 2538757 7562958 JTY_2307 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645359.1 2538305 D 561275 CDS YP_002645360.1 224990673 7562959 2538949..2539920 1 NC_012207.1 hypothetical protein 2539920 7562959 JTY_2308 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645360.1 2538949 D 561275 CDS YP_002645361.1 224990674 7562960 complement(2539926..2541869) 1 NC_012207.1 molecular chaperone; heat shock protein 90 2541869 htpG 7562960 htpG Mycobacterium bovis BCG str. Tokyo 172 heat shock protein 90 YP_002645361.1 2539926 R 561275 CDS YP_002645362.1 224990675 7563331 complement(2541943..2542875) 1 NC_012207.1 hypothetical protein 2542875 7563331 JTY_2310 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645362.1 2541943 R 561275 CDS YP_002645363.1 224990676 7562961 2542882..2543574 1 NC_012207.1 cutinase 2543574 cut2 7562961 cut2 Mycobacterium bovis BCG str. Tokyo 172 cutinase YP_002645363.1 2542882 D 561275 CDS YP_002645364.1 224990677 7563143 2543680..2543922 1 NC_012207.1 hypothetical protein 2543922 7563143 JTY_2312 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645364.1 2543680 D 561275 CDS YP_002645365.1 224990678 7562962 complement(2543963..2544886) 1 NC_012207.1 antibiotic-resistance protein 2544886 7562962 JTY_2313 Mycobacterium bovis BCG str. Tokyo 172 antibiotic-resistance protein YP_002645365.1 2543963 R 561275 CDS YP_002645366.1 224990679 7562963 complement(2544883..2545092) 1 NC_012207.1 hypothetical protein 2545092 7562963 JTY_2314 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645366.1 2544883 R 561275 CDS YP_002645367.1 224990680 7562964 2545676..2546965 1 NC_012207.1 Differs from Rv2305 by 1aa, D148G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2546965 7562964 JTY_2315 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645367.1 2545676 D 561275 CDS YP_002645368.1 224990681 7562965 2546975..2547568 1 NC_012207.1 Differs from Rv2306A by 1aa, V47I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2547568 7562965 JTY_2316 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645368.1 2546975 D 561275 CDS YP_002645369.1 224990682 7562966 2547355..2547789 1 NC_012207.1 hypothetical protein 2547789 7562966 JTY_2317 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645369.1 2547355 D 561275 CDS YP_002645370.1 224990683 7562967 complement(2547718..2548563) 1 NC_012207.1 Differs from Rv2307c by 2aa, T24M, W235R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2548563 7562967 JTY_2318 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645370.1 2547718 R 561275 CDS YP_002645371.1 224990684 7562968 complement(2549095..2549286) 1 NC_012207.1 hypothetical glycine rich protein 2549286 7562968 JTY_2319 Mycobacterium bovis BCG str. Tokyo 172 hypothetical glycine rich protein YP_002645371.1 2549095 R 561275 CDS YP_002645372.1 224990685 7562969 complement(2549371..2549802) 1 NC_012207.1 hypothetical glycine rich protein 2549802 7562969 JTY_2320 Mycobacterium bovis BCG str. Tokyo 172 hypothetical glycine rich protein YP_002645372.1 2549371 R 561275 CDS YP_002645373.1 224990686 7562970 complement(2549895..2550077) 1 NC_012207.1 hypothetical protein 2550077 7562970 JTY_2321 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645373.1 2549895 R 561275 CDS YP_002645374.1 224990687 7562971 2550286..2551002 1 NC_012207.1 Differs from Rv2308 by 1aa, V43G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2551002 7562971 JTY_2322 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645374.1 2550286 D 561275 CDS YP_002645375.1 224990688 7564466 complement(2551710..2552165) 1 NC_012207.1 integrase 2552165 7564466 JTY_2323 Mycobacterium bovis BCG str. Tokyo 172 integrase YP_002645375.1 2551710 R 561275 CDS YP_002645376.1 224990689 7562973 2552912..2553199 1 NC_012207.1 Differs from Rv2309A by 1aa, K53E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2553199 7562973 JTY_2324 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645376.1 2552912 D 561275 CDS YP_002645377.1 224990690 7562974 2553302..2553646 1 NC_012207.1 excisionase 2553646 7562974 JTY_2325 Mycobacterium bovis BCG str. Tokyo 172 excisionase YP_002645377.1 2553302 D 561275 CDS YP_002645378.1 224990691 7562975 2553751..2554275 1 NC_012207.1 hypothetical protein 2554275 7562975 JTY_2326 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645378.1 2553751 D 561275 CDS YP_002645379.1 224990692 7562976 2554353..2554622 1 NC_012207.1 hypothetical protein 2554622 7562976 JTY_2327 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645379.1 2554353 D 561275 CDS YP_002645380.1 224990693 7562977 complement(2554919..2555773) 1 NC_012207.1 hypothetical protein 2555773 7562977 JTY_2328 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645380.1 2554919 R 561275 CDS YP_002645381.1 224990694 7562978 complement(2555784..2557157) 1 NC_012207.1 hypothetical protein 2557157 7562978 JTY_2329 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645381.1 2555784 R 561275 CDS YP_002645382.1 224990695 7562979 complement(2557154..2558671) 1 NC_012207.1 hypothetical protein 2558671 7562979 JTY_2330 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645382.1 2557154 R 561275 CDS YP_002645383.1 224990696 7562980 2558705..2559577 1 NC_012207.1 Differs from Rv2316 by 1aa, L126V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; sugar-transport integral membrane protein ABC transporter 2559577 uspA 7562980 uspA Mycobacterium bovis BCG str. Tokyo 172 sugar-transport integral membrane protein ABC transporter YP_002645383.1 2558705 D 561275 CDS YP_002645384.1 224990697 7561669 2559564..2560388 1 NC_012207.1 sugar-transport integral membrane protein ABC transporter 2560388 uspB 7561669 uspB Mycobacterium bovis BCG str. Tokyo 172 sugar-transport integral membrane protein ABC transporter YP_002645384.1 2559564 D 561275 CDS YP_002645385.1 224990698 7561670 2560385..2561707 1 NC_012207.1 Differs from Rv2318 by 1aa, V354L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; periplasmic sugar-binding lipoprotein 2561707 uspC 7561670 uspC Mycobacterium bovis BCG str. Tokyo 172 periplasmic sugar-binding lipoprotein YP_002645385.1 2560385 D 561275 CDS YP_002645386.1 224990699 7561671 complement(2561715..2562593) 1 NC_012207.1 Differs from Rv2319c and Mb2346c by 1aa, G105E in BCG Pasteur and BCG Tokyo; hypothetical protein 2562593 7561671 JTY_2334 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645386.1 2561715 R 561275 CDS YP_002645387.1 224990700 7562981 complement(2562590..2564020) 1 NC_012207.1 cationic amino acid transport integral membrane protein 2564020 rocE 7562981 rocE Mycobacterium bovis BCG str. Tokyo 172 cationic amino acid transport integral membrane protein YP_002645387.1 2562590 R 561275 CDS YP_002645388.1 224990701 7561593 complement(2564021..2564566) 1 NC_012207.1 C-terminus part; ornithine aminotransferase 2564566 rocD2 7561593 rocD2 Mycobacterium bovis BCG str. Tokyo 172 ornithine aminotransferase YP_002645388.1 2564021 R 561275 CDS YP_002645389.1 224990702 7561592 complement(2564566..2565231) 1 NC_012207.1 N-terminus part; ornithine aminotransferase 2565231 rocD1 7561592 rocD1 Mycobacterium bovis BCG str. Tokyo 172 ornithine aminotransferase YP_002645389.1 2564566 R 561275 CDS YP_002645390.1 224990703 7561591 complement(2565228..2566136) 1 NC_012207.1 Differs from Rv2323c by 1aa, T113A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2566136 7561591 JTY_2338 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645390.1 2565228 R 561275 CDS YP_002645391.1 224990704 7562982 2566201..2566647 1 NC_012207.1 probably AsnC-family; transcriptional regulatory protein 2566647 7562982 JTY_2339 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645391.1 2566201 D 561275 CDS YP_002645392.1 224990705 7562983 complement(2566876..2567724) 1 NC_012207.1 hypothetical protein 2567724 7562983 JTY_2340 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645392.1 2566876 R 561275 CDS YP_002645393.1 224990706 7562984 complement(2567721..2569814) 1 NC_012207.1 transmembrane ATP-binding protein ABC transporter 2569814 7562984 JTY_2341 Mycobacterium bovis BCG str. Tokyo 172 transmembrane ATP-binding protein ABC transporter YP_002645393.1 2567721 R 561275 CDS YP_002645394.1 224990707 7562985 2569855..2570346 1 NC_012207.1 hypothetical protein 2570346 7562985 JTY_2342 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645394.1 2569855 D 561275 CDS YP_002645395.1 224990708 7562986 2570598..2571746 1 NC_012207.1 PE family protein 2571746 PE23 7562986 PE23 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002645395.1 2570598 D 561275 CDS YP_002645396.1 224990709 7561723 complement(2571781..2573328) 1 NC_012207.1 nitrite extrusion protein 1 2573328 narK1 7561723 narK1 Mycobacterium bovis BCG str. Tokyo 172 nitrite extrusion protein 1 YP_002645396.1 2571781 R 561275 CDS YP_002645397.1 224990710 7562449 complement(2573562..2574089) 1 NC_012207.1 Differs from Rv2330c and Mb2357c by 1aa, A97S in BCG Pasteur and BCG Tokyo; lipoprotein 2574089 lppP 7562449 lppP Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645397.1 2573562 R 561275 CDS YP_002645398.1 224990711 7560482 2574164..2574550 1 NC_012207.1 hypothetical protein 2574550 7560482 JTY_2346 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645398.1 2574164 D 561275 CDS YP_002645399.1 224990712 7562987 2574607..2574945 1 NC_012207.1 Differs from Rv2331A by 1aa, L46I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2574945 7562987 JTY_2347 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645399.1 2574607 D 561275 CDS YP_002645400.1 224990713 7562988 2574975..2576621 1 NC_012207.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 2576621 mez 7562988 mez Mycobacterium bovis BCG str. Tokyo 172 malate dehydrogenase YP_002645400.1 2574975 D 561275 CDS YP_002645401.1 224990714 7564469 complement(2576618..2578189) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, single base insertion (*-G) leads to a slightly longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (523 aa versus 537 aa). Also differs from Rv2333c by 2aa, Y69D, Q503H in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; integral membrane transport protein 2578189 7564469 JTY_2349 Mycobacterium bovis BCG str. Tokyo 172 integral membrane transport protein YP_002645401.1 2576618 R 561275 CDS YP_002645402.1 224990715 7562989 2578664..2579596 1 NC_012207.1 cysteine synthase A 2579596 cysK1 7562989 cysK1 Mycobacterium bovis BCG str. Tokyo 172 cysteine synthase A YP_002645402.1 2578664 D 561275 CDS YP_002645403.1 224990716 7563178 2579600..2580289 1 NC_012207.1 serine acetyltransferase 2580289 7563178 JTY_2351 Mycobacterium bovis BCG str. Tokyo 172 serine acetyltransferase YP_002645403.1 2579600 D 561275 CDS YP_002645404.1 224990717 7562990 2580705..2581673 1 NC_012207.1 hypothetical protein 2581673 7562990 JTY_2352 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645404.1 2580705 D 561275 CDS YP_002645405.1 224990718 7562991 complement(2581737..2582855) 1 NC_012207.1 Differs from Rv2337c by 1aa, V119G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2582855 7562991 JTY_2353 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645405.1 2581737 R 561275 CDS YP_002645406.1 224990719 7562992 complement(2582975..2583931) 1 NC_012207.1 hypothetical protein 2583931 moeW 7562992 moeW Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645406.1 2582975 R 561275 CDS YP_002645407.1 224990720 7563543 2584562..2587042 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (G-A) splits mmpL9 into 2 parts, mmpL9a and mmpL9b; transmembrane transport protein 2587042 mmpL9a 7563543 mmpL9a Mycobacterium bovis BCG str. Tokyo 172 transmembrane transport protein YP_002645407.1 2584562 D 561275 CDS YP_002645408.1 224990721 7564494 2587055..2587450 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (G-A) splits mmpL9 into 2 parts, mmpL9a and mmpL9b; transmembrane transport protein 2587450 mmpL9b 7564494 mmpL9b Mycobacterium bovis BCG str. Tokyo 172 transmembrane transport protein YP_002645408.1 2587055 D 561275 CDS YP_002645409.1 224990722 7564495 complement(2587536..2588777) 1 NC_012207.1 Differs from Rv2340c and Mb2369c by 1aa, T222D in BCG Pasteur and BCG Tokyo; PE-PGRS family protein 2588777 PE_PGRS39 7564495 PE_PGRS39 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002645409.1 2587536 R 561275 CDS YP_002645410.1 224990723 7562042 2589466..2589885 1 NC_012207.1 lipoprotein lppQ 2589885 lppQ 7562042 lppQ Mycobacterium bovis BCG str. Tokyo 172 lipoprotein lppQ YP_002645410.1 2589466 D 561275 CDS YP_002645411.1 224990724 7560483 2590141..2590398 1 NC_012207.1 hypothetical protein 2590398 7560483 JTY_2359 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645411.1 2590141 D 561275 CDS YP_002645412.1 224990725 7562993 complement(2590402..2592321) 1 NC_012207.1 synthesizes RNA primers at the replication forks; DNA primase 2592321 dnaG 7562993 dnaG Mycobacterium bovis BCG str. Tokyo 172 DNA primase YP_002645412.1 2590402 R 561275 CDS YP_002645413.1 224990726 7561503 complement(2592326..2593621) 1 NC_012207.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 2593621 dgt 7561503 dgt Mycobacterium bovis BCG str. Tokyo 172 deoxyguanosinetriphosphate triphosphohydrolase-like protein YP_002645413.1 2592326 R 561275 CDS YP_002645414.1 224990727 7561491 2593690..2595672 1 NC_012207.1 transmembrane protein 2595672 7561491 JTY_2362 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645414.1 2593690 D 561275 CDS YP_002645415.1 224990728 7562994 complement(2595757..2595939) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 8963 bp deletion (RD5) leads to the loss of the NH2 part of Rv2346c, and the 9 following CDSs up to Rv2356 including the 3 phospolipases C enzymes plcC, plcB and plcA, compared to the homolog in Mycobacterium tuberculosis H37Rv; EsaT-6 like protein 6 2595939 esxO 7562994 esxO Mycobacterium bovis BCG str. Tokyo 172 EsaT-6 like protein 6 YP_002645415.1 2595757 R 561275 CDS YP_002645416.1 224990729 7562886 complement(2595923..2597329) 1 NC_012207.1 Compared to Mycobacterium bovis, there has been a 2579bp bp deletion at position equivalent to M. bovis 2604493-2607071, this has resulted in an in-frame fusion of the 5'-end of PPE40 with the 3'-end of PPE71 probably due to a homologous recombination event between codons 68 and 174 of PPE40 as the PPE40 and PPE71 genes have identical 5'-ends (first 535 bp). Differs from Mb2376c(PPE71) by extra 11aa, insertion of A at position 68 due to 3bp insertion (present in PPE40) and STNVGSGNIG at position 307 due to 30 bp insertion. M. bovis BCG Pasteur and BCG Tokyo thus has three copies of tandem repeat STNVGSGNIG compared to two in Mb2376c. The 3'-end of PPE71 of M. bovis BCG Pasteur and BCG Tokyo have also been truncated as a result of the same deletion described in In Mycobacterium bovis, 8963 bp deletion (RD5); PPE family protein 2597329 PPE71 7562886 PPE71 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002645416.1 2595923 R 561275 CDS YP_002645417.1 224990730 7560802 complement(2597467..2598858) 1 NC_012207.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase 2598858 glyS 7560802 glyS Mycobacterium bovis BCG str. Tokyo 172 glycyl-tRNA synthetase YP_002645417.1 2597467 R 561275 CDS YP_002645418.1 224990731 7563266 2599040..2599447 1 NC_012207.1 probably ArsR-family; transcriptional regulatory protein 2599447 7563266 JTY_2366 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645418.1 2599040 D 561275 CDS YP_002645419.1 224990732 7562995 2599444..2599836 1 NC_012207.1 Differs from Rv2359 by 1aa, R64H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; ferric uptake regulation protein 2599836 furB 7562995 furB Mycobacterium bovis BCG str. Tokyo 172 ferric uptake regulation protein YP_002645419.1 2599444 D 561275 CDS YP_002645420.1 224990733 7561887 complement(2599944..2600372) 1 NC_012207.1 Differs from Rv2360c by 1aa, T66A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2600372 7561887 JTY_2368 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645420.1 2599944 R 561275 CDS YP_002645421.1 224990734 7562996 complement(2600372..2601262) 1 NC_012207.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; UDP pyrophosphate synthase 2601262 7562996 JTY_2369 Mycobacterium bovis BCG str. Tokyo 172 UDP pyrophosphate synthase YP_002645421.1 2600372 R 561275 CDS YP_002645422.1 224990735 7562997 complement(2601255..2602052) 1 NC_012207.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 2602052 recO 7562997 recO Mycobacterium bovis BCG str. Tokyo 172 DNA repair protein RecO YP_002645422.1 2601255 R 561275 CDS YP_002645423.1 224990736 7561561 2602114..2603568 1 NC_012207.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 2603568 amiA2 7561561 amiA2 Mycobacterium bovis BCG str. Tokyo 172 amidase YP_002645423.1 2602114 D 561275 CDS YP_002645424.1 224990737 7563968 complement(2603565..2604467) 1 NC_012207.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 2604467 era 7563968 era Mycobacterium bovis BCG str. Tokyo 172 GTP-binding protein Era YP_002645424.1 2603565 R 561275 CDS YP_002645425.1 224990738 7562872 complement(2604541..2604882) 1 NC_012207.1 hypothetical protein 2604882 7562872 JTY_2373 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645425.1 2604541 R 561275 CDS YP_002645426.1 224990739 7562998 complement(2604854..2606161) 1 NC_012207.1 transmembrane protein 2606161 7562998 JTY_2374 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645426.1 2604854 R 561275 CDS YP_002645427.1 224990740 7562999 complement(2606158..2606706) 1 NC_012207.1 metalloprotease 2606706 7562999 JTY_2375 Mycobacterium bovis BCG str. Tokyo 172 metalloprotease YP_002645427.1 2606158 R 561275 CDS YP_002645428.1 224990741 7563000 complement(2606710..2607768) 1 NC_012207.1 phoH-like protein 2607768 phoH1 7563000 phoH1 Mycobacterium bovis BCG str. Tokyo 172 phoH-like protein YP_002645428.1 2606710 R 561275 CDS YP_002645429.1 224990742 7562409 complement(2607740..2608042) 1 NC_012207.1 hypothetical protein 2608042 7562409 JTY_2377 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645429.1 2607740 R 561275 CDS YP_002645430.1 224990743 7563001 complement(2608039..2609352) 1 NC_012207.1 hypothetical protein 2609352 7563001 JTY_2378 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645430.1 2608039 R 561275 CDS YP_002645431.1 224990744 7563002 2609547..2609732 1 NC_012207.1 PE-PGRS family protein 2609732 PE_PGRS40 7563002 PE_PGRS40 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002645431.1 2609547 D 561275 CDS YP_002645432.1 224990745 7561787 complement(2609831..2610619) 1 NC_012207.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 2610619 7561787 JTY_2380 Mycobacterium bovis BCG str. Tokyo 172 16S ribosomal RNA methyltransferase RsmE YP_002645432.1 2609831 R 561275 CDS YP_002645433.1 224990746 7563003 complement(2610633..2611781) 1 NC_012207.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 2611781 dnaJ2 7563003 dnaJ2 Mycobacterium bovis BCG str. Tokyo 172 molecular chaperone DnaJ YP_002645433.1 2610633 R 561275 CDS YP_002645434.1 224990747 7561505 complement(2611856..2612887) 1 NC_012207.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 2612887 hrcA 7561505 hrcA Mycobacterium bovis BCG str. Tokyo 172 heat-inducible transcription repressor YP_002645434.1 2611856 R 561275 CDS YP_002645435.1 224990748 7563324 2613059..2613376 1 NC_012207.1 hypothetical protein 2613376 7563324 JTY_2383 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645435.1 2613059 D 561275 CDS YP_002645436.1 224990749 7563004 complement(2613403..2613909) 1 NC_012207.1 low molecular weight antigen 2613909 cfp2 7563004 cfp2 Mycobacterium bovis BCG str. Tokyo 172 low molecular weight antigen YP_002645436.1 2613403 R 561275 CDS YP_002645437.1 224990750 7562098 complement(2614009..2614224) 1 NC_012207.1 Differs from Rv2377c by 1aa, A69V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2614224 mbtH 7562098 mbtH Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645437.1 2614009 R 561275 CDS YP_002645438.1 224990751 7564428 complement(2614202..2615497) 1 NC_012207.1 lysine-N-oxygenase 2615497 mbtG 7564428 mbtG Mycobacterium bovis BCG str. Tokyo 172 lysine-N-oxygenase YP_002645438.1 2614202 R 561275 CDS YP_002645439.1 224990752 7564427 complement(2615494..2619879) 1 NC_012207.1 Differs from Rv2379c by 1aa, D589E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; peptide synthetase 2619879 mbtF 7564427 mbtF Mycobacterium bovis BCG str. Tokyo 172 peptide synthetase YP_002645439.1 2615494 R 561275 CDS YP_002645440.1 224990753 7564426 complement(2619861..2624909) 1 NC_012207.1 peptide synthetase 2624909 mbtE 7564426 mbtE Mycobacterium bovis BCG str. Tokyo 172 peptide synthetase YP_002645440.1 2619861 R 561275 CDS YP_002645441.1 224990754 7564425 complement(2625049..2628063) 1 NC_012207.1 polyketide synthase 2628063 mbtD 7564425 mbtD Mycobacterium bovis BCG str. Tokyo 172 polyketide synthase YP_002645441.1 2625049 R 561275 CDS YP_002645442.1 224990755 7564424 complement(2628063..2629397) 1 NC_012207.1 polyketide synthase 2629397 mbtC 7564424 mbtC Mycobacterium bovis BCG str. Tokyo 172 polyketide synthase YP_002645442.1 2628063 R 561275 CDS YP_002645443.1 224990756 7564423 complement(2629387..2633631) 1 NC_012207.1 Differs from Rv2383c by 2aa, Q264R, P1253T, and from Mb2404c by 1aa, P1253T BCG Pasteur and BCG Tokyo; phenyloxazoline synthase 2633631 mbtB 7564423 mbtB Mycobacterium bovis BCG str. Tokyo 172 phenyloxazoline synthase YP_002645443.1 2629387 R 561275 CDS YP_002645444.1 224990757 7564422 2633730..2635427 1 NC_012207.1 salicyl-S-ArCP synthetase; salicyl-AMP ligase 2635427 mbtA 7564422 mbtA Mycobacterium bovis BCG str. Tokyo 172 salicyl-AMP ligase YP_002645444.1 2633730 D 561275 CDS YP_002645445.1 224990758 7564421 2635523..2636443 1 NC_012207.1 acetyl hydrolase 2636443 mbtJ 7564421 mbtJ Mycobacterium bovis BCG str. Tokyo 172 acetyl hydrolase YP_002645445.1 2635523 D 561275 CDS YP_002645446.1 224990759 7564430 complement(2636447..2637799) 1 NC_012207.1 catalyzes conversion of chorismate to salicylate, in mycobactin siderophore construction; requires Mg(2+) for function; salicylate synthase MbtI 2637799 mbtI 7564430 mbtI Mycobacterium bovis BCG str. Tokyo 172 salicylate synthase MbtI YP_002645446.1 2636447 R 561275 CDS YP_002645447.1 224990760 7564429 2638559..2639812 1 NC_012207.1 hypothetical protein 2639812 7564429 JTY_2395 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645447.1 2638559 D 561275 CDS YP_002645448.1 224990761 7563005 complement(2639809..2640936) 1 NC_012207.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 2640936 hemN 7563005 hemN Mycobacterium bovis BCG str. Tokyo 172 coproporphyrinogen III oxidase YP_002645448.1 2639809 R 561275 CDS YP_002645449.1 224990762 7563304 complement(2641042..2641506) 1 NC_012207.1 resuscitation-promoting factor 2641506 rpfD 7563304 rpfD Mycobacterium bovis BCG str. Tokyo 172 resuscitation-promoting factor YP_002645449.1 2641042 R 561275 CDS YP_002645450.1 224990763 7561599 complement(2641503..2642060) 1 NC_012207.1 Differs from Mb2411c by 1aa, I33T in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; hypothetical protein 2642060 7561599 JTY_2398 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645450.1 2641503 R 561275 CDS YP_002645451.1 224990764 7563006 2642473..2644164 1 NC_012207.1 ferredoxin-dependent nitrite reductase 2644164 nirA 7563006 nirA Mycobacterium bovis BCG str. Tokyo 172 ferredoxin-dependent nitrite reductase YP_002645451.1 2642473 D 561275 CDS YP_002645452.1 224990765 7562461 2644161..2644925 1 NC_012207.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 2644925 cysH 7562461 cysH Mycobacterium bovis BCG str. Tokyo 172 phosphoadenosine phosphosulfate reductase YP_002645452.1 2644161 D 561275 CDS YP_002645453.1 224990766 7563177 2644922..2645821 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur and BCG Tokyo, duplication of 54 bp segment after codon 3 leads to additional 18 aa and two tandem copies of motif PATMQSAAMLRSGAIEAP, compared to its ortholog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis AF2122/97; hypothetical protein 2645821 7563177 JTY_2401 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645453.1 2644922 D 561275 CDS YP_002645454.1 224990767 7563007 2645858..2647789 1 NC_012207.1 Differs from Rv2394 by 1aa Q396R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; gamma-glutamyltranspeptidase precursor 2647789 ggtB 7563007 ggtB Mycobacterium bovis BCG str. Tokyo 172 gamma-glutamyltranspeptidase precursor YP_002645454.1 2645858 D 561275 CDS YP_002645455.1 224990768 7561914 2647920..2648360 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, as in Mycobacterium bovis, a frameshift due to a single base insertion (*-T) splits Rv2395 into 2 parts. The frameshift occurs after the 44th codon; integral membrane protein 2648360 7561914 JTY_2403 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002645455.1 2647920 D 561275 CDS YP_002645456.1 224990769 7563008 2648374..2649924 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-T) splits Rv2395 into 2 parts. BCG_2410 also differs from Rv2395 by 1aa, P396S in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; integral membrane protein 2649924 7563008 JTY_2404 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002645456.1 2648374 D 561275 CDS YP_002645457.1 224990770 7563009 2650648..2651730 1 NC_012207.1 Identical to Mb2418 of Mycobacterium bovis, including 3 bp deletion (GCC-*) that leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (360 aa versus 361 aa) due to deletion of A95 in BCG Pasteur and Tokyo. Also differs from Rv2396 by 2aa, N26S, S324N in BCG Pasteur. Differs from Rv2396 by 3aa, N26S, C218G, S324N in BCG Tokyo.; PE-PGRS family protein 2651730 PE_PGRS41 7563009 PE_PGRS41 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002645457.1 2650648 D 561275 CDS YP_002645458.1 224990771 7561788 complement(2651755..2652810) 1 NC_012207.1 sulfate-transport ATP-binding protein ABC transporter 2652810 cysA1 7561788 cysA1 Mycobacterium bovis BCG str. Tokyo 172 sulfate-transport ATP-binding protein ABC transporter YP_002645458.1 2651755 R 561275 CDS YP_002645459.1 224990772 7563172 complement(2652827..2653645) 1 NC_012207.1 Differs from Rv2398c by 1aa, A141G, and from Mb2420c by 1aa, R264H in BCG Pasteur and BCG Tokyo; sulfate-transport integral membrane protein ABC transporter 2653645 cysW 7563172 cysW Mycobacterium bovis BCG str. Tokyo 172 sulfate-transport integral membrane protein ABC transporter YP_002645459.1 2652827 R 561275 CDS YP_002645460.1 224990773 7561463 complement(2653642..2654493) 1 NC_012207.1 sulfate-transport integral membrane protein ABC transporter 2654493 cysT 7561463 cysT Mycobacterium bovis BCG str. Tokyo 172 sulfate-transport integral membrane protein ABC transporter YP_002645460.1 2653642 R 561275 CDS YP_002645461.1 224990774 7561461 complement(2654490..2655560) 1 NC_012207.1 sulfate-binding lipoprotein 2655560 subI 7561461 subI Mycobacterium bovis BCG str. Tokyo 172 sulfate-binding lipoprotein YP_002645461.1 2654490 R 561275 CDS YP_002645462.1 224990775 7561812 2655574..2655903 1 NC_012207.1 hypothetical protein 2655903 7561812 JTY_2410 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645462.1 2655574 D 561275 CDS YP_002645463.1 224990776 7563010 complement(2655888..2656091) 1 NC_012207.1 hypothetical protein 2656091 7563010 JTY_2411 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645463.1 2655888 R 561275 CDS YP_002645464.1 224990777 7563011 2656375..2658303 1 NC_012207.1 hypothetical protein 2658303 7563011 JTY_2412 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645464.1 2656375 D 561275 CDS YP_002645465.1 224990778 7563012 complement(2658381..2659136) 1 NC_012207.1 Differs from Rv2403c by 1aa, L127V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 2659136 lppR 7563012 lppR Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645465.1 2658381 R 561275 CDS YP_002645466.1 224990779 7560484 complement(2659133..2661094) 1 NC_012207.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 2661094 lepA 7560484 lepA Mycobacterium bovis BCG str. Tokyo 172 GTP-binding protein LepA YP_002645466.1 2659133 R 561275 CDS YP_002645467.1 224990780 7562811 2661115..2661684 1 NC_012207.1 hypothetical protein 2661684 7562811 JTY_2415 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645467.1 2661115 D 561275 CDS YP_002645468.1 224990781 7563013 complement(2661855..2662283) 1 NC_012207.1 hypothetical protein 2662283 7563013 JTY_2416 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645468.1 2661855 R 561275 CDS YP_002645469.1 224990782 7563014 2662543..2663385 1 NC_012207.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2663385 7563014 JTY_2417 Mycobacterium bovis BCG str. Tokyo 172 ribonuclease Z YP_002645469.1 2662543 D 561275 CDS YP_002645470.1 224990783 7563015 2663978..2664697 1 NC_012207.1 PE family-related protein 2664697 PE24 7563015 PE24 Mycobacterium bovis BCG str. Tokyo 172 PE family-related protein YP_002645470.1 2663978 D 561275 CDS YP_002645471.1 224990784 7561724 complement(2664455..2665294) 1 NC_012207.1 hypothetical protein 2665294 7561724 JTY_2419 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645471.1 2664455 R 561275 CDS YP_002645472.1 224990785 7563016 complement(2665294..2666271) 1 NC_012207.1 hypothetical protein 2666271 7563016 JTY_2420 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645472.1 2665294 R 561275 CDS YP_002645473.1 224990786 7563017 complement(2666271..2667926) 1 NC_012207.1 hypothetical protein 2667926 7563017 JTY_2421 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645473.1 2666271 R 561275 CDS YP_002645474.1 224990787 7563018 2668036..2668296 1 NC_012207.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 2668296 rpsT 7563018 rpsT Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S20 YP_002645474.1 2668036 D 561275 CDS YP_002645475.1 224990788 7560749 complement(2668312..2669262) 1 NC_012207.1 hypothetical protein 2669262 7560749 JTY_2423 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645475.1 2668312 R 561275 CDS YP_002645476.1 224990789 7563019 complement(2669293..2670837) 1 NC_012207.1 In Mycobacterium bovis, a single base insertion (*-T) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (523 aa versus 514 aa); hypothetical protein 2670837 7563019 JTY_2424 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645476.1 2669293 R 561275 CDS YP_002645477.1 224990790 7563840 complement(2670852..2671745) 1 NC_012207.1 Differs from Rv2415c by 1aa, L291R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2671745 7563840 JTY_2425 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645477.1 2670852 R 561275 CDS YP_002645478.1 224990791 7563841 complement(2672085..2673311) 1 NC_012207.1 Differs from Mb2439c by 1aa, T76A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2673311 7563841 JTY_2426 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645478.1 2672085 R 561275 CDS YP_002645479.1 224990792 7563842 complement(2673433..2674275) 1 NC_012207.1 hypothetical protein 2674275 7563842 JTY_2427 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645479.1 2673433 R 561275 CDS YP_002645480.1 224990793 7563843 complement(2674356..2675099) 1 NC_012207.1 hypothetical protein 2675099 7563843 JTY_2428 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645480.1 2674356 R 561275 CDS YP_002645481.1 224990794 7563844 complement(2675089..2675760) 1 NC_012207.1 Differs from Mb2442c by 1aa, A165V in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; phosphoglycerate mutase 2675760 7563844 JTY_2429 Mycobacterium bovis BCG str. Tokyo 172 phosphoglycerate mutase YP_002645481.1 2675089 R 561275 CDS YP_002645482.1 224990795 7563845 complement(2675757..2676140) 1 NC_012207.1 Differs from Rv2420c and Mb2443c by insertion of 1aa, Pro, at position 126 due to 3bp insertion (GCG) at position equivalent to Mycobacterium bovis 2685985-2685986 in BCG Pasteur and BCG Tokyo; hypothetical protein 2676140 7563845 JTY_2430 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645482.1 2675757 R 561275 CDS YP_002645483.1 224990796 7563846 complement(2676137..2676772) 1 NC_012207.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 2676772 nadD 7563846 nadD Mycobacterium bovis BCG str. Tokyo 172 nicotinic acid mononucleotide adenylyltransferase YP_002645483.1 2676137 R 561275 CDS YP_002645484.1 224990797 7563588 2677047..2677319 1 NC_012207.1 hypothetical protein 2677319 7563588 JTY_2432 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645484.1 2677047 D 561275 CDS YP_002645485.1 224990798 7563847 2677561..2678607 1 NC_012207.1 hypothetical protein 2678607 7563847 JTY_2433 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645485.1 2677561 D 561275 CDS YP_002645486.1 224990799 7563848 complement(2678740..2679432) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 2bp deletion (GT-*) splits Rv2424c into 2 parts. Differsfrom Rv2424c by 3aa, I172T, A173T and Y192H; transposase 2679432 7563848 JTY_2434 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002645486.1 2678740 R 561275 CDS YP_002645487.1 224990800 7563849 complement(2679446..2679739) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 2bp deletion (GT-*) splits Rv2424c into 2 parts; transposase 2679739 7563849 JTY_2435 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002645487.1 2679446 R 561275 CDS YP_002645488.1 224990801 7563850 complement(2679828..2681270) 1 NC_012207.1 hypothetical protein 2681270 7563850 JTY_2436 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645488.1 2679828 R 561275 CDS YP_002645489.1 224990802 7563851 complement(2681270..2682145) 1 NC_012207.1 Differs from Rv2426c by 1aa, L113F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2682145 7563851 JTY_2437 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645489.1 2681270 R 561275 CDS YP_002645490.1 224990803 7563852 complement(2682172..2683419) 1 NC_012207.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 2683419 proA 7563852 proA Mycobacterium bovis BCG str. Tokyo 172 gamma-glutamyl phosphate reductase YP_002645490.1 2682172 R 561275 CDS YP_002645491.1 224990804 7563854 2684135..2684722 1 NC_012207.1 alkyl hydroperoxide reductase 2684722 ahpC 7563854 ahpC Mycobacterium bovis BCG str. Tokyo 172 alkyl hydroperoxide reductase YP_002645491.1 2684135 D 561275 CDS YP_002645492.1 224990805 7563951 2684748..2685281 1 NC_012207.1 alkyl hydroperoxide reductase 2685281 ahpD 7563951 ahpD Mycobacterium bovis BCG str. Tokyo 172 alkyl hydroperoxide reductase YP_002645492.1 2684748 D 561275 CDS YP_002645493.1 224990806 7563952 complement(2685278..2685862) 1 NC_012207.1 PPE family protein 2685862 PPE41 7563952 PPE41 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002645493.1 2685278 R 561275 CDS YP_002645494.1 224990807 7562179 complement(2685909..2686208) 1 NC_012207.1 PE family protein 2686208 PE25 7562179 PE25 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002645494.1 2685909 R 561275 CDS YP_002645495.1 224990808 7561725 complement(2686379..2686789) 1 NC_012207.1 hypothetical protein 2686789 7561725 JTY_2445 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645495.1 2686379 R 561275 CDS YP_002645496.1 224990809 7563855 complement(2686786..2687076) 1 NC_012207.1 hypothetical protein 2687076 7563855 JTY_2446 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645496.1 2686786 R 561275 CDS YP_002645497.1 224990810 7563856 complement(2687057..2688502) 1 NC_012207.1 transmembrane protein 2688502 7563856 JTY_2447 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645497.1 2687057 R 561275 CDS YP_002645498.1 224990811 7563857 complement(2688499..2690691) 1 NC_012207.1 cyclase 2690691 7563857 JTY_2448 Mycobacterium bovis BCG str. Tokyo 172 cyclase YP_002645498.1 2688499 R 561275 CDS YP_002645499.1 224990812 7563858 2691172..2692086 1 NC_012207.1 Differs from Rv2436 by 2aa, V274A, A282V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; ribokinase 2692086 rbsK 7563858 rbsK Mycobacterium bovis BCG str. Tokyo 172 ribokinase YP_002645499.1 2691172 D 561275 CDS YP_002645500.1 224990813 7561552 2692318..2692737 1 NC_012207.1 hypothetical protein 2692737 7561552 JTY_2450 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645500.1 2692318 D 561275 CDS YP_002645501.1 224990814 7563859 complement(2692734..2694773) 1 NC_012207.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 2694773 nadE 7563859 nadE Mycobacterium bovis BCG str. Tokyo 172 NAD synthetase YP_002645501.1 2692734 R 561275 CDS YP_002645502.1 224990815 7563589 2694651..2694929 1 NC_012207.1 hypothetical protein 2694929 7563589 JTY_2452 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645502.1 2694651 D 561275 CDS YP_002645503.1 224990816 7563860 complement(2695059..2696189) 1 NC_012207.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 2696189 proB 7563860 proB Mycobacterium bovis BCG str. Tokyo 172 gamma-glutamyl kinase YP_002645503.1 2695059 R 561275 CDS YP_002645504.1 224990817 7560825 complement(2696189..2697628) 1 NC_012207.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 2697628 obgE 7560825 obgE Mycobacterium bovis BCG str. Tokyo 172 GTPase ObgE YP_002645504.1 2696189 R 561275 CDS YP_002645505.1 224990818 7562491 complement(2697714..2697974) 1 NC_012207.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 2697974 rpmA 7562491 rpmA Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L27 YP_002645505.1 2697714 R 561275 CDS YP_002645506.1 224990819 7560713 complement(2697989..2698303) 1 NC_012207.1 50S ribosomal protein L21 2698303 rplU 7560713 rplU Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L21 YP_002645506.1 2697989 R 561275 CDS YP_002645507.1 224990820 7561621 2698651..2700126 1 NC_012207.1 C4-dicarboxylate-transport transmembrane protein 2700126 dctA 7561621 dctA Mycobacterium bovis BCG str. Tokyo 172 C4-dicarboxylate-transport transmembrane protein YP_002645507.1 2698651 D 561275 CDS YP_002645508.1 224990821 7561471 complement(2700065..2702926) 1 NC_012207.1 ribonuclease E 2702926 rne 7561471 rne Mycobacterium bovis BCG str. Tokyo 172 ribonuclease E YP_002645508.1 2700065 R 561275 CDS YP_002645509.1 224990822 7561587 complement(2703256..2703666) 1 NC_012207.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 2703666 ndk 7561587 ndk Mycobacterium bovis BCG str. Tokyo 172 nucleoside diphosphate kinase YP_002645509.1 2703256 R 561275 CDS YP_002645510.1 224990823 7562458 complement(2703709..2704080) 1 NC_012207.1 integral membrane protein 2704080 7562458 JTY_2460 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002645510.1 2703709 R 561275 CDS YP_002645511.1 224990824 7563861 complement(2704077..2705540) 1 NC_012207.1 folylpolyglutamate synthase protein 2705540 folC 7563861 folC Mycobacterium bovis BCG str. Tokyo 172 folylpolyglutamate synthase protein YP_002645511.1 2704077 R 561275 CDS YP_002645512.1 224990825 7563420 complement(2705537..2708167) 1 NC_012207.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 2708167 valS 7563420 valS Mycobacterium bovis BCG str. Tokyo 172 valyl-tRNA synthetase YP_002645512.1 2705537 R 561275 CDS YP_002645513.1 224990826 7561677 complement(2708255..2709514) 1 NC_012207.1 Differs from Rv2449c and Mb2476c by 1aa, C273R in BCG Pasteur and BCG Tokyo; hypothetical protein 2709514 7561677 JTY_2463 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645513.1 2708255 R 561275 CDS YP_002645514.1 224990827 7563862 complement(2709525..2710121) 1 NC_012207.1 In Mycobacterum bovis BCG Tokyo, 1bp deletion leads to a shortly longer product compared with its homolog in Mycobacterium tuberculosis H37Rv (Rv2450c), Mycobacterium bovis, and BCG Pasteur (198aa vs 172aa), and leads to a product with different C-terminal part.; resuscitation-promoting factor 2710121 rpfE 7563862 rpfE Mycobacterium bovis BCG str. Tokyo 172 resuscitation-promoting factor YP_002645514.1 2709525 R 561275 CDS YP_002645515.1 224990828 7561600 2710203..2710601 1 NC_012207.1 Differs from Rv2451 by 1aa, D63N in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 2710601 7561600 JTY_2465 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645515.1 2710203 D 561275 CDS YP_002645516.1 224990829 7563863 complement(2710789..2710935) 1 NC_012207.1 hypothetical protein 2710935 7563863 JTY_2466 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645516.1 2710789 R 561275 CDS YP_002645517.1 224990830 7563864 complement(2710959..2711564) 1 NC_012207.1 MobA; links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide; involved in molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein A 2711564 mobA 7563864 mobA Mycobacterium bovis BCG str. Tokyo 172 molybdopterin-guanine dinucleotide biosynthesis protein A YP_002645517.1 2710959 R 561275 CDS YP_002645518.1 224990831 7563535 complement(2711566..2712687) 1 NC_012207.1 catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin; 2-oxoglutarate ferredoxin oxidoreductase subunit beta 2712687 7563535 JTY_2468 Mycobacterium bovis BCG str. Tokyo 172 2-oxoglutarate ferredoxin oxidoreductase subunit beta YP_002645518.1 2711566 R 561275 CDS YP_002645519.1 224990832 7563865 complement(2712684..2714645) 1 NC_012207.1 oxidoreductase subunit alpha 2714645 7563865 JTY_2469 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase subunit alpha YP_002645519.1 2712684 R 561275 CDS YP_002645520.1 224990833 7563866 complement(2714877..2716133) 1 NC_012207.1 integral membrane transport protein 2716133 7563866 JTY_2470 Mycobacterium bovis BCG str. Tokyo 172 integral membrane transport protein YP_002645520.1 2714877 R 561275 CDS YP_002645521.1 224990834 7563867 complement(2716149..2717429) 1 NC_012207.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 2717429 clpX 7563867 clpX Mycobacterium bovis BCG str. Tokyo 172 ATP-dependent protease ATP-binding subunit ClpX YP_002645521.1 2716149 R 561275 CDS YP_002645522.1 224990835 7562112 2717720..2718628 1 NC_012207.1 converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines; homocysteine methyltransferase 2718628 mmuM 7562112 mmuM Mycobacterium bovis BCG str. Tokyo 172 homocysteine methyltransferase YP_002645522.1 2717720 D 561275 CDS YP_002645523.1 224990836 7563520 2718795..2720321 1 NC_012207.1 Differs from Mb2486 by 1aa, M55I in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; integral membrane transport protein 2720321 7563520 JTY_2473 Mycobacterium bovis BCG str. Tokyo 172 integral membrane transport protein YP_002645523.1 2718795 D 561275 CDS YP_002645524.1 224990837 7563868 complement(2720472..2721116) 1 NC_012207.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 2721116 clpP2 7563868 clpP2 Mycobacterium bovis BCG str. Tokyo 172 ATP-dependent Clp protease proteolytic subunit YP_002645524.1 2720472 R 561275 CDS YP_002645525.1 224990838 7562110 complement(2721113..2721715) 1 NC_012207.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 2721715 clpP 7562110 clpP Mycobacterium bovis BCG str. Tokyo 172 ATP-dependent Clp protease proteolytic subunit YP_002645525.1 2721113 R 561275 CDS YP_002645526.1 224990839 7562109 complement(2721832..2723232) 1 NC_012207.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 2723232 tig 7562109 tig Mycobacterium bovis BCG str. Tokyo 172 trigger factor YP_002645526.1 2721832 R 561275 CDS YP_002645527.1 224990840 7563269 2723596..2724780 1 NC_012207.1 esterase/lipase 2724780 lipP 7563269 lipP Mycobacterium bovis BCG str. Tokyo 172 esterase/lipase YP_002645527.1 2723596 D 561275 CDS YP_002645528.1 224990841 7562843 complement(2724800..2725606) 1 NC_012207.1 DNA glycosylase 2725606 7562843 JTY_2478 Mycobacterium bovis BCG str. Tokyo 172 DNA glycosylase YP_002645528.1 2724800 R 561275 CDS YP_002645529.1 224990842 7563869 complement(2725612..2726100) 1 NC_012207.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 2726100 rpiB 7563869 rpiB Mycobacterium bovis BCG str. Tokyo 172 ribose-5-phosphate isomerase B YP_002645529.1 2725612 R 561275 CDS YP_002645530.1 224990843 7561602 complement(2726202..2726825) 1 NC_012207.1 hypothetical protein 2726825 7561602 JTY_2480 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645530.1 2726202 R 561275 CDS YP_002645531.1 224990844 7563870 2726927..2729512 1 NC_012207.1 Differs from Rv2467 and Mb2494 by 1aa, M18I in Mycobacterium bovis BCG Pasteur.; aminopeptidase N 2729512 pepN 7563870 pepN Mycobacterium bovis BCG str. Tokyo 172 aminopeptidase N YP_002645531.1 2726927 D 561275 CDS YP_002645532.1 224990845 7561745 complement(2729585..2730088) 1 NC_012207.1 hypothetical protein 2730088 7561745 JTY_2482 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645532.1 2729585 R 561275 CDS YP_002645533.1 224990846 7563871 complement(2730308..2730976) 1 NC_012207.1 Differs from Rv2469c by 2aa, G28S, S99A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2730976 7563871 JTY_2483 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645533.1 2730308 R 561275 CDS YP_002645534.1 224990847 7563872 2731119..2731505 1 NC_012207.1 oxygen-binding protein; globin 2731505 glbO 7563872 glbO Mycobacterium bovis BCG str. Tokyo 172 globin YP_002645534.1 2731119 D 561275 CDS YP_002645535.1 224990848 7561917 2731505..2733145 1 NC_012207.1 Differs from Rv2471 by 1aa, S206W in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; alpha-glucosidase 2733145 aglA 7561917 aglA Mycobacterium bovis BCG str. Tokyo 172 alpha-glucosidase YP_002645535.1 2731505 D 561275 CDS YP_002645536.1 224990849 7563949 2733213..2733506 1 NC_012207.1 hypothetical protein 2733506 7563949 JTY_2486 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645536.1 2733213 D 561275 CDS YP_002645537.1 224990850 7563873 2733509..2734225 1 NC_012207.1 alanine and proline rich membrane protein 2734225 7563873 JTY_2487 Mycobacterium bovis BCG str. Tokyo 172 alanine and proline rich membrane protein YP_002645537.1 2733509 D 561275 CDS YP_002645538.1 224990851 7563874 complement(2734257..2734910) 1 NC_012207.1 Differs from Mb2501c by 1aa, A30V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2734910 7563874 JTY_2488 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645538.1 2734257 R 561275 CDS YP_002645539.1 224990852 7563875 complement(2734916..2735332) 1 NC_012207.1 hypothetical protein 2735332 7563875 JTY_2489 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645539.1 2734916 R 561275 CDS YP_002645540.1 224990853 7563876 complement(2735329..2740200) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 3 bp deletion (cgg-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1623 aa versus 1624 aa). Differs from Rv2476c by 2aa, loss of A501 due to 3 bp deletion and G1042S; NAD-dependent glutamate dehydrogenase 2740200 gdh 7563876 gdh Mycobacterium bovis BCG str. Tokyo 172 NAD-dependent glutamate dehydrogenase YP_002645540.1 2735329 R 561275 CDS YP_002645541.1 224990854 7561912 complement(2740304..2741980) 1 NC_012207.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 2741980 7561912 JTY_2491 Mycobacterium bovis BCG str. Tokyo 172 ABC transporter ATP-binding protein YP_002645541.1 2740304 R 561275 CDS YP_002645542.1 224990855 7563877 complement(2742061..2742546) 1 NC_012207.1 hypothetical protein 2742546 7563877 JTY_2492 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645542.1 2742061 R 561275 CDS YP_002645543.1 224990856 7563878 complement(2743155..2743478) 1 NC_012207.1 hypothetical protein 2743478 7563878 JTY_2493 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645543.1 2743155 R 561275 CDS YP_002645544.1 224990857 7563879 complement(2743494..2745863) 1 NC_012207.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 2745863 plsB2 7563879 plsB2 Mycobacterium bovis BCG str. Tokyo 172 glycerol-3-phosphate acyltransferase YP_002645544.1 2743494 R 561275 CDS YP_002645545.1 224990858 7562129 complement(2745860..2747602) 1 NC_012207.1 Differs from Rv2483c by 1aa, G189C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; L-3-phosphoserine phosphatase, 1-acyl-sn-glycerol-3-phosphate acyltransferase; transmembrane phospholipid biosynthesis enzyme 2747602 plsC 7562129 plsC Mycobacterium bovis BCG str. Tokyo 172 transmembrane phospholipid biosynthesis enzyme YP_002645545.1 2745860 R 561275 CDS YP_002645546.1 224990859 7562130 complement(2747599..2749074) 1 NC_012207.1 Differs from Rv2484c by 1aa, D466G in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 2749074 7562130 JTY_2496 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645546.1 2747599 R 561275 CDS YP_002645547.1 224990860 7563880 complement(2749303..2750568) 1 NC_012207.1 carboxylesterase 2750568 lipQ 7563880 lipQ Mycobacterium bovis BCG str. Tokyo 172 carboxylesterase YP_002645547.1 2749303 R 561275 CDS YP_002645548.1 224990861 7563995 2750930..2751700 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2751700 echA14 7563995 echA14 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002645548.1 2750930 D 561275 CDS YP_002645549.1 224990862 7562365 complement(2752380..2753963) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts, the first due to a single base insertion (*-C) and the second due to a single base deletion (G-*) splits PE_PGRS42 into 3 parts, PE_PGRS42a and PE_PGRS42b and PE_PGRS42d while in Mycobacterium bovis BCG Pasteur and BCG Tokyo, PE_PGRS42a and PE_GRRS42b are fused; PE-PGRS family protein 2753963 PE_PGRS42ab 7562365 PE_PGRS42ab Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002645549.1 2752380 R 561275 CDS YP_002645550.1 224990863 7562364 complement(2754045..2757458) 1 NC_012207.1 Differs from Rv2488c and Mb2515c by 1aa E535D in BCG Pasteur and BCG Tokyo; LuxR-family; transcriptional regulatory protein 2757458 7562364 JTY_2501 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645550.1 2754045 R 561275 CDS YP_002645551.1 224990864 7563881 complement(2757424..2757723) 1 NC_012207.1 hypothetical alanine rich protein 2757723 7563881 JTY_2502 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine rich protein YP_002645551.1 2757424 R 561275 CDS YP_002645552.1 224990865 7563882 complement(2757960..2761286) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS43 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 8 bp insertion (*-GGGGGGGG ) splits PE_PGRS43 into 2 parts, PE_PGRS43a and PE_PGRS43b while in Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 1bp insertion (equivalent to Mycobacterium tuberculosis H37Rv position 2804942-2804943) causes a different frameshift but at same place, 3bp:GCC deletion in BCG Pasteur after 2409:G of Mycobacterium bovis, 1bp:T deletion in BCG Tokyo at 2931:T of Mycobacterium bovis.; PE-PGRS family protein 2761286 PE_PGRS43b 7563882 PE_PGRS43b Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002645552.1 2757960 R 561275 CDS YP_002645553.1 224990866 7562367 complement(2761378..2762805) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS43 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 8 bp insertion (*-GGGGGGGG ) splits PE_PGRS43 into 2 parts, PE_PGRS43a and PE_PGRS43b while in Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 1 bp insertion (equivalent to Mycobacterium tuberculosis H37Rv position 2804942-2804943) causes a different frameshift but at same place, 3bp:GCC deletion in BCG Pasteur after 2409:G of Mycobacterium bovis, 1bp:T deletion in BCG Tokyo at 2931:T of Mycobacterium bovis.; PE-PGRS family protein 2762805 PE_PGRS43a 7562367 PE_PGRS43a Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002645553.1 2761378 R 561275 CDS YP_002645554.1 224990867 7562366 2763234..2763857 1 NC_012207.1 hypothetical protein 2763857 7562366 JTY_2505 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645554.1 2763234 D 561275 CDS YP_002645555.1 224990868 7563883 2763847..2764599 1 NC_012207.1 Differs from Rv2492 by 1aa, D70A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 2764599 7563883 JTY_2506 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645555.1 2763847 D 561275 CDS YP_002645556.1 224990869 7563884 2764652..2764873 1 NC_012207.1 hypothetical protein 2764873 7563884 JTY_2507 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645556.1 2764652 D 561275 CDS YP_002645557.1 224990870 7563885 2764879..2765304 1 NC_012207.1 hypothetical protein 2765304 7563885 JTY_2508 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645557.1 2764879 D 561275 CDS YP_002645558.1 224990871 7563886 complement(2765327..2766508) 1 NC_012207.1 Differs from Rv2495c by 2aa, A107T, W208R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; branched-chain alpha-keto acid dehydrogenase subunit E2 2766508 pdhC 7563886 pdhC Mycobacterium bovis BCG str. Tokyo 172 branched-chain alpha-keto acid dehydrogenase subunit E2 YP_002645558.1 2765327 R 561275 CDS YP_002645559.1 224990872 7561707 complement(2766505..2767551) 1 NC_012207.1 Differs from Rv2496c by 1aa, S201G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; pyruvate dehydrogenase E1 component subunit beta 2767551 pdhB 7561707 pdhB Mycobacterium bovis BCG str. Tokyo 172 pyruvate dehydrogenase E1 component subunit beta YP_002645559.1 2766505 R 561275 CDS YP_002645560.1 224990873 7561450 complement(2767562..2768665) 1 NC_012207.1 pyruvate dehydrogenase E1 component subunit alpha 2768665 pdhA 7561450 pdhA Mycobacterium bovis BCG str. Tokyo 172 pyruvate dehydrogenase E1 component subunit alpha YP_002645560.1 2767562 R 561275 CDS YP_002645561.1 224990874 7562527 complement(2768924..2769745) 1 NC_012207.1 citrate (pro-3s)-lyase subunit beta 2769745 citE 7562527 citE Mycobacterium bovis BCG str. Tokyo 172 citrate (pro-3s)-lyase subunit beta YP_002645561.1 2768924 R 561275 CDS YP_002645562.1 224990875 7562106 complement(2769742..2770299) 1 NC_012207.1 oxidase regulatory-related protein 2770299 7562106 JTY_2513 Mycobacterium bovis BCG str. Tokyo 172 oxidase regulatory-related protein YP_002645562.1 2769742 R 561275 CDS YP_002645563.1 224990876 7563887 complement(2770296..2771480) 1 NC_012207.1 acyl-CoA dehydrogenase 2771480 fadE19 7563887 fadE19 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002645563.1 2770296 R 561275 CDS YP_002645564.1 224990877 7563367 complement(2771485..2773449) 1 NC_012207.1 acetyl-/propionyl-coenzyme A carboxylase alpha chain subunit alpha 2773449 accA1 7563367 accA1 Mycobacterium bovis BCG str. Tokyo 172 acetyl-/propionyl-coenzyme A carboxylase alpha chain subunit alpha YP_002645564.1 2771485 R 561275 CDS YP_002645565.1 224990878 7564329 complement(2773454..2775043) 1 NC_012207.1 Differs from Rv2502c by 2aa, S77G, L343F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acetyl-/propionyl-coa carboxylase subunit beta 2775043 accD1 7564329 accD1 Mycobacterium bovis BCG str. Tokyo 172 acetyl-/propionyl-coa carboxylase subunit beta YP_002645565.1 2773454 R 561275 CDS YP_002645566.1 224990879 7564332 complement(2775040..2775696) 1 NC_012207.1 succinyl-CoA:3-ketoacid-coenzyme A transferase subunit beta 2775696 scoB 7564332 scoB Mycobacterium bovis BCG str. Tokyo 172 succinyl-CoA:3-ketoacid-coenzyme A transferase subunit beta YP_002645566.1 2775040 R 561275 CDS YP_002645567.1 224990880 7560759 complement(2775693..2776439) 1 NC_012207.1 succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha 2776439 scoA 7560759 scoA Mycobacterium bovis BCG str. Tokyo 172 succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha YP_002645567.1 2775693 R 561275 CDS YP_002645568.1 224990881 7560758 complement(2776522..2778165) 1 NC_012207.1 Differs from Rv2505c and Mb2533c by 1aa, A381T in BCG Pasteur and BCG Tokyo; AMP-binding protein 2778165 fadD35 7560758 fadD35 Mycobacterium bovis BCG str. Tokyo 172 AMP-binding protein YP_002645568.1 2776522 R 561275 CDS YP_002645569.1 224990882 7563351 2778281..2778928 1 NC_012207.1 probably TetR-family; transcriptional regulatory protein 2778928 7563351 JTY_2520 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645569.1 2778281 D 561275 CDS YP_002645570.1 224990883 7563888 2779007..2779828 1 NC_012207.1 proline rich membrane protein 2779828 7563888 JTY_2521 Mycobacterium bovis BCG str. Tokyo 172 proline rich membrane protein YP_002645570.1 2779007 D 561275 CDS YP_002645571.1 224990884 7563889 complement(2779825..2781162) 1 NC_012207.1 integral membrane leucine and alanine rich protein 2781162 7563889 JTY_2522 Mycobacterium bovis BCG str. Tokyo 172 integral membrane leucine and alanine rich protein YP_002645571.1 2779825 R 561275 CDS YP_002645572.1 224990885 7563890 2781247..2782053 1 NC_012207.1 short-chain type dehydrogenase/reductase 2782053 7563890 JTY_2523 Mycobacterium bovis BCG str. Tokyo 172 short-chain type dehydrogenase/reductase YP_002645572.1 2781247 D 561275 CDS YP_002645573.1 224990886 7563891 complement(2782057..2783658) 1 NC_012207.1 hypothetical protein 2783658 7563891 JTY_2524 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645573.1 2782057 R 561275 CDS YP_002645574.1 224990887 7563892 2783726..2784373 1 NC_012207.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 2784373 orn 7563892 orn Mycobacterium bovis BCG str. Tokyo 172 oligoribonuclease YP_002645574.1 2783726 D 561275 CDS YP_002645575.1 224990888 7563319 complement(2785125..2786372) 1 NC_012207.1 transposase for insertion sequence element IS1081 2786372 7563319 JTY_2526 Mycobacterium bovis BCG str. Tokyo 172 transposase for insertion sequence element IS1081 YP_002645575.1 2785125 R 561275 CDS YP_002645576.1 224990889 7563893 2786372..2786509 1 NC_012207.1 hypothetical protein 2786509 7563893 JTY_2527 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645576.1 2786372 D 561275 CDS YP_002645577.1 224990890 7563894 2786730..2787152 1 NC_012207.1 Differs from Rv2513 by 1aa, K122T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2787152 7563894 JTY_2528 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645577.1 2786730 D 561275 CDS YP_002645578.1 224990891 7563895 complement(2787446..2787907) 1 NC_012207.1 hypothetical protein 2787907 7563895 JTY_2529 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645578.1 2787446 R 561275 CDS YP_002645579.1 224990892 7563896 complement(2787913..2789160) 1 NC_012207.1 hypothetical protein 2789160 7563896 JTY_2530 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645579.1 2787913 R 561275 CDS YP_002645580.1 224990893 7563897 complement(2789279..2790082) 1 NC_012207.1 hypothetical protein 2790082 7563897 JTY_2531 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645580.1 2789279 R 561275 CDS YP_002645581.1 224990894 7563898 complement(2790079..2790330) 1 NC_012207.1 hypothetical protein 2790330 7563898 JTY_2532 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645581.1 2790079 R 561275 CDS YP_002645582.1 224990895 7563899 complement(2790678..2791904) 1 NC_012207.1 lipoprotein 2791904 lppS 7563899 lppS Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645582.1 2790678 R 561275 CDS YP_002645583.1 224990896 7560544 2792354..2793832 1 NC_012207.1 Identical to Rv2519 but differs from Mb2548 by 1aa, G173A, due to 2bp substitution at position equivalent to Mycobacterium bovis 2803099-2803100 CC-GG in BCG Pasteur and BCG Tokyo.; PE family protein 2793832 PE26 7560544 PE26 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002645583.1 2792354 D 561275 CDS YP_002645584.1 224990897 7561726 complement(2793957..2794184) 1 NC_012207.1 hypothetical protein 2794184 7561726 JTY_2535 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645584.1 2793957 R 561275 CDS YP_002645585.1 224990898 7563900 2794253..2794726 1 NC_012207.1 Differs from Mb2550 by 1aa, V122M in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; bacterioferritin comigratory protein 2794726 bcp 7563900 bcp Mycobacterium bovis BCG str. Tokyo 172 bacterioferritin comigratory protein YP_002645585.1 2794253 D 561275 CDS YP_002645586.1 224990899 7562060 complement(2794698..2796110) 1 NC_012207.1 hypothetical protein 2796110 7562060 JTY_2537 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645586.1 2794698 R 561275 CDS YP_002645587.1 224990900 7563901 complement(2796107..2796499) 1 NC_012207.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 2796499 acpS 7563901 acpS Mycobacterium bovis BCG str. Tokyo 172 4'-phosphopantetheinyl transferase YP_002645587.1 2796107 R 561275 CDS YP_002645588.1 224990901 7563933 complement(2796692..2805901) 1 NC_012207.1 fatty acid synthase 2805901 fas 7563933 fas Mycobacterium bovis BCG str. Tokyo 172 fatty acid synthase YP_002645588.1 2796692 R 561275 CDS YP_002645589.1 224990902 7563395 complement(2806421..2807143) 1 NC_012207.1 hypothetical protein 2807143 7563395 JTY_2540 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645589.1 2806421 R 561275 CDS YP_002645590.1 224990903 7563902 2807660..2807887 1 NC_012207.1 hypothetical protein 2807887 7563902 JTY_2541 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645590.1 2807660 D 561275 CDS YP_002645591.1 224990904 7563903 2807884..2808285 1 NC_012207.1 hypothetical protein 2808285 7563903 JTY_2542 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645591.1 2807884 D 561275 CDS YP_002645592.1 224990905 7563904 complement(2808320..2809240) 1 NC_012207.1 Differs from Rv2528c by 1aa, L94P, and Mb2557c by 2aa, L94P, E259Q in BCG Pasteur and BCG Tokyo; restriction system protein 2809240 mrr 7563904 mrr Mycobacterium bovis BCG str. Tokyo 172 restriction system protein YP_002645592.1 2808320 R 561275 CDS YP_002645593.1 224990906 7563561 2809444..2810835 1 NC_012207.1 Differs from Mb2558 by 1aa, G94E in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2810835 7563561 JTY_2544 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645593.1 2809444 D 561275 CDS YP_002645594.1 224990907 7563905 complement(2810836..2811255) 1 NC_012207.1 hypothetical protein 2811255 7563905 JTY_2545 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645594.1 2810836 R 561275 CDS YP_002645595.1 224990908 7563906 complement(2811252..2811476) 1 NC_012207.1 hypothetical protein 2811476 7563906 JTY_2546 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645595.1 2811252 R 561275 CDS YP_002645596.1 224990909 7563907 complement(2811507..2814350) 1 NC_012207.1 amino acid decarboxylase 2814350 7563907 JTY_2547 Mycobacterium bovis BCG str. Tokyo 172 amino acid decarboxylase YP_002645596.1 2811507 R 561275 CDS YP_002645597.1 224990910 7563908 complement(2814422..2814823) 1 NC_012207.1 hypothetical protein 2814823 7563908 JTY_2548 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645597.1 2814422 R 561275 CDS YP_002645598.1 224990911 7563909 complement(2814823..2815293) 1 NC_012207.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 2815293 nusB 7563909 nusB Mycobacterium bovis BCG str. Tokyo 172 transcription antitermination protein NusB YP_002645598.1 2814823 R 561275 CDS YP_002645599.1 224990912 7562489 complement(2815296..2815859) 1 NC_012207.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 2815859 efp 7562489 efp Mycobacterium bovis BCG str. Tokyo 172 elongation factor P YP_002645599.1 2815296 R 561275 CDS YP_002645600.1 224990913 7561541 complement(2815869..2816987) 1 NC_012207.1 cytoplasmic peptidase 2816987 pepQ 7561541 pepQ Mycobacterium bovis BCG str. Tokyo 172 cytoplasmic peptidase YP_002645600.1 2815869 R 561275 CDS YP_002645601.1 224990914 7561746 2817021..2817713 1 NC_012207.1 transmembrane protein 2817713 7561746 JTY_2552 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645601.1 2817021 D 561275 CDS YP_002645602.1 224990915 7563910 complement(2817717..2818160) 1 NC_012207.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 2818160 aroD 7563910 aroD Mycobacterium bovis BCG str. Tokyo 172 3-dehydroquinate dehydratase YP_002645602.1 2817717 R 561275 CDS YP_002645603.1 224990916 7563998 complement(2818157..2819245) 1 NC_012207.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 2819245 aroB 7563998 aroB Mycobacterium bovis BCG str. Tokyo 172 3-dehydroquinate synthase YP_002645603.1 2818157 R 561275 CDS YP_002645604.1 224990917 7563997 complement(2819242..2819772) 1 NC_012207.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 2819772 aroK 7563997 aroK Mycobacterium bovis BCG str. Tokyo 172 shikimate kinase YP_002645604.1 2819242 R 561275 CDS YP_002645605.1 224990918 7564002 complement(2819776..2820981) 1 NC_012207.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 2820981 aroF 7564002 aroF Mycobacterium bovis BCG str. Tokyo 172 chorismate synthase YP_002645605.1 2819776 R 561275 CDS YP_002645606.1 224990919 7564000 2820996..2821403 1 NC_012207.1 hypothetical alanine rich protein 2821403 7564000 JTY_2557 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine rich protein YP_002645606.1 2820996 D 561275 CDS YP_002645607.1 224990920 7563911 2821699..2822910 1 NC_012207.1 Differs from Rv2542 by 1aa, A211T in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 2822910 7563911 JTY_2558 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645607.1 2821699 D 561275 CDS YP_002645608.1 224990921 7563912 2823037..2823696 1 NC_012207.1 lipoprotein 2823696 lppA 7563912 lppA Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645608.1 2823037 D 561275 CDS YP_002645609.1 224990922 7560466 2823693..2824352 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovisBCG Pasteur, and BCG Tokyo, there is a 656 bp insertion, relative to Mycobacterium tuberculosis strain H37Rv, which leads to lppR gene, probably by duplication of llpA or lppB; lipoprotein 2824352 lprR 7560466 lprR Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645609.1 2823693 D 561275 CDS YP_002645610.1 224990923 7560535 2824349..2825011 1 NC_012207.1 lipoprotein 2825011 lppB 7560535 lppB Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645610.1 2824349 D 561275 CDS YP_002645611.1 224990924 7560467 2825008..2825286 1 NC_012207.1 hypothetical protein 2825286 7560467 JTY_2562 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645611.1 2825008 D 561275 CDS YP_002645612.1 224990925 7563913 2825379..2825792 1 NC_012207.1 hypothetical protein 2825792 7563913 JTY_2563 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645612.1 2825379 D 561275 CDS YP_002645613.1 224990926 7563914 2825831..2826088 1 NC_012207.1 hypothetical protein 2826088 7563914 JTY_2564 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645613.1 2825831 D 561275 CDS YP_002645614.1 224990927 7563915 2826085..2826462 1 NC_012207.1 hypothetical protein 2826462 7563915 JTY_2565 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645614.1 2826085 D 561275 CDS YP_002645615.1 224990928 7563916 complement(2826952..2827347) 1 NC_012207.1 hypothetical protein 2827347 7563916 JTY_2566 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645615.1 2826952 R 561275 CDS YP_002645616.1 224990929 7563917 complement(2827344..2827589) 1 NC_012207.1 hypothetical protein 2827589 7563917 JTY_2567 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645616.1 2827344 R 561275 CDS YP_002645617.1 224990930 7563918 complement(2828000..2828419) 1 NC_012207.1 hypothetical protein 2828419 7563918 JTY_2568 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645617.1 2828000 R 561275 CDS YP_002645618.1 224990931 7563919 complement(2828431..2829213) 1 NC_012207.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 2829213 aroE 7563919 aroE Mycobacterium bovis BCG str. Tokyo 172 shikimate 5-dehydrogenase YP_002645618.1 2828431 R 561275 CDS YP_002645619.1 224990932 7563999 complement(2829236..2830489) 1 NC_012207.1 hypothetical protein 2830489 7563999 JTY_2570 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645619.1 2829236 R 561275 CDS YP_002645620.1 224990933 7563920 complement(2830482..2830994) 1 NC_012207.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 2830994 7563920 JTY_2571 Mycobacterium bovis BCG str. Tokyo 172 Holliday junction resolvase-like protein YP_002645620.1 2830482 R 561275 CDS YP_002645621.1 224990934 7563921 complement(2830995..2833709) 1 NC_012207.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 2833709 alaS 7563921 alaS Mycobacterium bovis BCG str. Tokyo 172 alanyl-tRNA synthetase YP_002645621.1 2830995 R 561275 CDS YP_002645622.1 224990935 7563954 complement(2833800..2834189) 1 NC_012207.1 hypothetical protein 2834189 7563954 JTY_2573 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645622.1 2833800 R 561275 CDS YP_002645623.1 224990936 7561368 2834296..2834970 1 NC_012207.1 hypothetical protein 2834970 7561368 JTY_2574 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645623.1 2834296 D 561275 CDS YP_002645624.1 224990937 7561369 2835055..2835765 1 NC_012207.1 hypothetical protein 2835765 7561369 JTY_2575 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645624.1 2835055 D 561275 CDS YP_002645625.1 224990938 7561370 complement(2835795..2837153) 1 NC_012207.1 Differs from Rv2559c by 1aa, D317G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; recombination factor protein RarA 2837153 7561370 JTY_2576 Mycobacterium bovis BCG str. Tokyo 172 recombination factor protein RarA YP_002645625.1 2835795 R 561275 CDS YP_002645626.1 224990939 7561371 2837299..2838276 1 NC_012207.1 Differs from Rv2560 by 1aa, L210V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; proline and glycine rich transmembrane protein 2838276 7561371 JTY_2577 Mycobacterium bovis BCG str. Tokyo 172 proline and glycine rich transmembrane protein YP_002645626.1 2837299 D 561275 CDS YP_002645627.1 224990940 7561372 2838633..2839370 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2561 and Rv2562 exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base deletion(g-*) results in a single product which is more similar to Rv2561; hypothetical protein 2839370 7561372 JTY_2578 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645627.1 2838633 D 561275 CDS YP_002645628.1 224990941 7561373 2839513..2840562 1 NC_012207.1 glutamine-transport transmembrane protein ABC transporter 2840562 7561373 JTY_2579 Mycobacterium bovis BCG str. Tokyo 172 glutamine-transport transmembrane protein ABC transporter YP_002645628.1 2839513 D 561275 CDS YP_002645629.1 224990942 7561374 2840565..2841557 1 NC_012207.1 glutamine-transport ATP-binding protein ABC transporter 2841557 glnQ 7561374 glnQ Mycobacterium bovis BCG str. Tokyo 172 glutamine-transport ATP-binding protein ABC transporter YP_002645629.1 2840565 D 561275 CDS YP_002645630.1 224990943 7561934 2841834..2843585 1 NC_012207.1 hypothetical protein 2843585 7561934 JTY_2581 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645630.1 2841834 D 561275 CDS YP_002645631.1 224990944 7561375 2843596..2845197 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 2bp deletion (GC-*) splits Rv2566 into 2 parts. Differs from first part of Rv2566 by 3aa, S10G, S270A, L315V and from Mb2595 by 1aa, L315V in BCG Pasteur and BCG Tokyo; hypothetical protein 2845197 7561375 JTY_2582 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645631.1 2843596 D 561275 CDS YP_002645632.1 224990945 7561376 2845223..2847016 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 2bp deletion (GC-*) splits Rv2566 into 2 parts. Differs from Rv2566 by 2aa, P67L, E326G, and from Mb2596 by 1aa, E326G in BCG Pasteur and BCG Tokyo; hypothetical protein 2847016 7561376 JTY_2583 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645632.1 2845223 D 561275 CDS YP_002645633.1 224990946 7561377 2847016..2849670 1 NC_012207.1 Differs from Rv2567 by 1aa, R645Q in BCG Pasteur and BCG Tokyo; hypothetical alanine and leucine rich protein 2849670 7561377 JTY_2584 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine and leucine rich protein YP_002645633.1 2847016 D 561275 CDS YP_002645634.1 224990947 7561378 complement(2849667..2850692) 1 NC_012207.1 hypothetical protein 2850692 7561378 JTY_2585 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645634.1 2849667 R 561275 CDS YP_002645635.1 224990948 7561379 complement(2850685..2851629) 1 NC_012207.1 hypothetical protein 2851629 7561379 JTY_2586 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645635.1 2850685 R 561275 CDS YP_002645636.1 224990949 7561380 2851733..2852122 1 NC_012207.1 hypothetical protein 2852122 7561380 JTY_2587 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645636.1 2851733 D 561275 CDS YP_002645637.1 224990950 7561381 complement(2852114..2853181) 1 NC_012207.1 Differs from Rv2571c and Mb2601c by 1aa, C68R in Mycobacterium bovis BCG Pasteur.; transmembrane alanine and valine and leucine rich protein 2853181 7561381 JTY_2588 Mycobacterium bovis BCG str. Tokyo 172 transmembrane alanine and valine and leucine rich protein YP_002645637.1 2852114 R 561275 CDS YP_002645638.1 224990951 7561382 complement(2853188..2855023) 1 NC_012207.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 2855023 aspS 7561382 aspS Mycobacterium bovis BCG str. Tokyo 172 aspartyl-tRNA synthetase YP_002645638.1 2853188 R 561275 CDS YP_002645639.1 224990952 7562045 2855263..2856003 1 NC_012207.1 2-dehydropantoate 2-reductase 2856003 7562045 JTY_2590 Mycobacterium bovis BCG str. Tokyo 172 2-dehydropantoate 2-reductase YP_002645639.1 2855263 D 561275 CDS YP_002645640.1 224990953 7561383 2856026..2856529 1 NC_012207.1 hypothetical protein 2856529 7561383 JTY_2591 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645640.1 2856026 D 561275 CDS YP_002645641.1 224990954 7561384 2856559..2857440 1 NC_012207.1 membrane glycine rich protein 2857440 7561384 JTY_2592 Mycobacterium bovis BCG str. Tokyo 172 membrane glycine rich protein YP_002645641.1 2856559 D 561275 CDS YP_002645642.1 224990955 7561385 complement(2857446..2857910) 1 NC_012207.1 hypothetical protein 2857910 7561385 JTY_2593 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645642.1 2857446 R 561275 CDS YP_002645643.1 224990956 7561386 2858138..2859727 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, Rv2577 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (G-A) splits Rv2577 into 2 parts, Mb2607 and Mb2608; hypothetical protein 2859727 7561386 JTY_2594 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645643.1 2858138 D 561275 CDS YP_002645644.1 224990957 7561387 complement(2859729..2860751) 1 NC_012207.1 hypothetical protein 2860751 7561387 JTY_2595 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645644.1 2859729 R 561275 CDS YP_002645645.1 224990958 7561388 2860859..2861761 1 NC_012207.1 catalyzes the cleavage of carbon-halogen bonds in aliphatic compounds forming a primary alcohol and a halide; haloalkane dehalogenase 2861761 dhaA 7561388 dhaA Mycobacterium bovis BCG str. Tokyo 172 haloalkane dehalogenase YP_002645645.1 2860859 D 561275 CDS YP_002645646.1 224990959 7561492 complement(2862041..2863312) 1 NC_012207.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2863312 hisS 7561492 hisS Mycobacterium bovis BCG str. Tokyo 172 histidyl-tRNA synthetase YP_002645646.1 2862041 R 561275 CDS YP_002645647.1 224990960 7563318 complement(2863309..2863983) 1 NC_012207.1 glyoxalase II 2863983 7563318 JTY_2598 Mycobacterium bovis BCG str. Tokyo 172 glyoxalase II YP_002645647.1 2863309 R 561275 CDS YP_002645648.1 224990961 7561389 2864034..2864960 1 NC_012207.1 Differs from Rv2582 by 1aa, F66V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; peptidyl-prolyl cis-trans isomerase B 2864960 ppiB 7561389 ppiB Mycobacterium bovis BCG str. Tokyo 172 peptidyl-prolyl cis-trans isomerase B YP_002645648.1 2864034 D 561275 CDS YP_002645649.1 224990962 7560807 complement(2865046..2867418) 1 NC_012207.1 GTP pyrophosphokinase 2867418 relA 7560807 relA Mycobacterium bovis BCG str. Tokyo 172 GTP pyrophosphokinase YP_002645649.1 2865046 R 561275 CDS YP_002645650.1 224990963 7561565 complement(2867449..2868120) 1 NC_012207.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 2868120 apt 7561565 apt Mycobacterium bovis BCG str. Tokyo 172 adenine phosphoribosyltransferase YP_002645650.1 2867449 R 561275 CDS YP_002645651.1 224990964 7563981 complement(2868224..2869897) 1 NC_012207.1 Differs from Rv2585c by 1aa, S462C; lipoprotein 2869897 7563981 JTY_2602 Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645651.1 2868224 R 561275 CDS YP_002645652.1 224990965 7561390 complement(2869903..2871231) 1 NC_012207.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 2871231 secF 7561390 secF Mycobacterium bovis BCG str. Tokyo 172 preprotein translocase subunit SecF YP_002645652.1 2869903 R 561275 CDS YP_002645653.1 224990966 7560775 complement(2871235..2872956) 1 NC_012207.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 2872956 secD 7560775 secD Mycobacterium bovis BCG str. Tokyo 172 preprotein translocase subunit SecD YP_002645653.1 2871235 R 561275 CDS YP_002645654.1 224990967 7560772 complement(2873066..2873413) 1 NC_012207.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 2873413 yajC 7560772 yajC Mycobacterium bovis BCG str. Tokyo 172 preprotein translocase subunit YajC YP_002645654.1 2873066 R 561275 CDS YP_002645655.1 224990968 7561702 2873580..2874929 1 NC_012207.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2874929 gabT 7561702 gabT Mycobacterium bovis BCG str. Tokyo 172 4-aminobutyrate aminotransferase YP_002645655.1 2873580 D 561275 CDS YP_002645656.1 224990969 7561894 2875091..2878597 1 NC_012207.1 Differs from Rv2590 by 1aa, Y309F, and from Mb2621 by 1aa, A1106T in BCG Pasteur and BCG Tokyo; fatty-acid-CoA ligase 2878597 fadD9 7561894 fadD9 Mycobacterium bovis BCG str. Tokyo 172 fatty-acid-CoA ligase YP_002645656.1 2875091 D 561275 CDS YP_002645657.1 224990970 7563357 2878771..2880411 1 NC_012207.1 Differs from Rv2591 by extra 3 aa resulting from same 9 bp in-frame insertion as in Mycobacterium bovis(*-GGCGGCACC) and by 2aa S415G, D463G in BCG Pasteur and BCG Tokyo; PE-PGRS family protein 2880411 PE_PGRS44 7563357 PE_PGRS44 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002645657.1 2878771 D 561275 CDS YP_002645658.1 224990971 7562368 complement(2880428..2881462) 1 NC_012207.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 2881462 ruvB 7562368 ruvB Mycobacterium bovis BCG str. Tokyo 172 Holliday junction DNA helicase RuvB YP_002645658.1 2880428 R 561275 CDS YP_002645659.1 224990972 7560752 complement(2881459..2882049) 1 NC_012207.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 2882049 ruvA 7560752 ruvA Mycobacterium bovis BCG str. Tokyo 172 Holliday junction DNA helicase RuvA YP_002645659.1 2881459 R 561275 CDS YP_002645660.1 224990973 7560751 complement(2882046..2882612) 1 NC_012207.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 2882612 ruvC 7560751 ruvC Mycobacterium bovis BCG str. Tokyo 172 Holliday junction resolvase YP_002645660.1 2882046 R 561275 CDS YP_002645661.1 224990974 7560753 2882721..2882966 1 NC_012207.1 hypothetical protein 2882966 7560753 JTY_2612 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645661.1 2882721 D 561275 CDS YP_002645662.1 224990975 7561391 2882963..2883367 1 NC_012207.1 Differs from Rv2596 by 1aa, R77C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2883367 7561391 JTY_2613 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645662.1 2882963 D 561275 CDS YP_002645663.1 224990976 7561392 2883584..2884204 1 NC_012207.1 hypothetical protein 2884204 7561392 JTY_2614 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645663.1 2883584 D 561275 CDS YP_002645664.1 224990977 7561393 2884215..2884709 1 NC_012207.1 hypothetical protein 2884709 7561393 JTY_2615 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645664.1 2884215 D 561275 CDS YP_002645665.1 224990978 7561394 2884706..2885137 1 NC_012207.1 Differs from Rv2599 by 1aa, I12S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2885137 7561394 JTY_2616 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645665.1 2884706 D 561275 CDS YP_002645666.1 224990979 7561395 2885219..2885425 1 NC_012207.1 First 64 aa identical to N-terminal part of Rv2600 and Mb2631 but then frameshifts due to 10bp deletion at position equivalent to Mycobacterium bovis coordinates 2895640-2895649. Results in BCG Pasteur and BCG Tokyo orthologs of Mb2631 and Rv2600 being in two parts; integral membrane protein 2885425 7561395 JTY_2617 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002645666.1 2885219 D 561275 CDS YP_002645667.1 224990980 7561396 2885431..2885610 1 NC_012207.1 All 59aa are identical to C-terminal part of Rv2600 and Mb2631 owing to frameshifts due to 10bp deletion at position equivalent to Mycobacterium bovis coordinates 2895640-2895649. Results in BCG Pasteur and BCG Tokyo orthologs of Mb2631 and Rv2600 being in two parts, both of which encode hydrophobic proteins; integral membrane protein 2885610 7561396 JTY_2618 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002645667.1 2885431 D 561275 CDS YP_002645668.1 224990981 7561397 2885607..2887178 1 NC_012207.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 2887178 speE 7561397 speE Mycobacterium bovis BCG str. Tokyo 172 spermidine synthase YP_002645668.1 2885607 D 561275 CDS YP_002645669.1 224990982 7561804 2887289..2887576 1 NC_012207.1 hypothetical protein 2887576 7561804 JTY_2620 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645669.1 2887289 D 561275 CDS YP_002645670.1 224990983 7561398 2887563..2888003 1 NC_012207.1 hypothetical protein 2888003 7561398 JTY_2621 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645670.1 2887563 D 561275 CDS YP_002645671.1 224990984 7561399 complement(2888024..2888779) 1 NC_012207.1 hypothetical protein 2888779 7561399 JTY_2622 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645671.1 2888024 R 561275 CDS YP_002645672.1 224990985 7561400 complement(2888912..2889508) 1 NC_012207.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 2889508 7561400 JTY_2623 Mycobacterium bovis BCG str. Tokyo 172 glutamine amidotransferase subunit PdxT YP_002645672.1 2888912 R 561275 CDS YP_002645673.1 224990986 7561401 complement(2889516..2890361) 1 NC_012207.1 Differs from Rv2605c by 1aa, L85F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acyl-CoA thioesterase II 2890361 tesB2 7561401 tesB2 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA thioesterase II YP_002645673.1 2889516 R 561275 CDS YP_002645674.1 224990987 7561841 complement(2890390..2891289) 1 NC_012207.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 2891289 7561841 JTY_2625 Mycobacterium bovis BCG str. Tokyo 172 pyridoxal biosynthesis lyase PdxS YP_002645674.1 2890390 R 561275 CDS YP_002645675.1 224990988 7561402 2891417..2892091 1 NC_012207.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 2892091 pdxH 7561402 pdxH Mycobacterium bovis BCG str. Tokyo 172 pyridoxamine 5'-phosphate oxidase YP_002645675.1 2891417 D 561275 CDS YP_002645676.1 224990989 7561708 2892265..2894007 1 NC_012207.1 Differs from Rv2608 by 1aa, S281P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PPE family protein 2894007 PPE42 7561708 PPE42 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002645676.1 2892265 D 561275 CDS YP_002645677.1 224990990 7562180 complement(2894029..2895084) 1 NC_012207.1 hypothetical protein 2895084 7562180 JTY_2628 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645677.1 2894029 R 561275 CDS YP_002645678.1 224990991 7561403 complement(2895084..2896220) 1 NC_012207.1 alpha-mannosyltransferase 2896220 pimA 7561403 pimA Mycobacterium bovis BCG str. Tokyo 172 alpha-mannosyltransferase YP_002645678.1 2895084 R 561275 CDS YP_002645679.1 224990992 7562421 complement(2896231..2897181) 1 NC_012207.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 2897181 7562421 JTY_2630 Mycobacterium bovis BCG str. Tokyo 172 lipid A biosynthesis lauroyl acyltransferase YP_002645679.1 2896231 R 561275 CDS YP_002645680.1 224990993 7561404 complement(2897178..2897831) 1 NC_012207.1 phosphatidylinositol synthase 2897831 pgsA1 7561404 pgsA1 Mycobacterium bovis BCG str. Tokyo 172 phosphatidylinositol synthase YP_002645680.1 2897178 R 561275 CDS YP_002645681.1 224990994 7562401 complement(2897828..2898415) 1 NC_012207.1 hypothetical protein 2898415 7562401 JTY_2632 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645681.1 2897828 R 561275 CDS YP_002645682.1 224990995 7561405 complement(2898408..2900486) 1 NC_012207.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 2900486 thrS 7561405 thrS Mycobacterium bovis BCG str. Tokyo 172 threonyl-tRNA synthetase YP_002645682.1 2898408 R 561275 CDS YP_002645683.1 224990996 7561853 2900595..2900822 1 NC_012207.1 Differs from Mb2647 by 1aa, R57H in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; hypothetical protein 2900822 7561853 JTY_2634 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645683.1 2900595 D 561275 CDS YP_002645684.1 224990997 7561406 complement(2900819..2901988) 1 NC_012207.1 In Mycobacterium bovis, a 9 bp in-frame insertion (*-CCGCCGTTT) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 461 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 7bp deletion at position corresponding to M. bovis 2944835-2944841 splits PE_PGRS45 in two parts; PE-PGRS family protein 2901988 PE_PGRS45b 7561406 PE_PGRS45b Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002645684.1 2900819 R 561275 CDS YP_002645685.1 224990998 7562370 complement(2901976..2902206) 1 NC_012207.1 In Mycobacterium bovis, a 9 bp in-frame insertion (*-CCGCCGTTT) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 461 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 7bp deletion at position corresponding to M. bovis 2944835-2944841 splits PE_PGRS45 in two parts. Differs from Rv2615c by 1aa, V40A in BCG Pasteur and BCG Tokyo; PE-PGRS family protein 2902206 PE_PGRS45a 7562370 PE_PGRS45a Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002645685.1 2901976 R 561275 CDS YP_002645686.1 224990999 7562369 2902551..2903051 1 NC_012207.1 Differs from Rv2616 by 1aa, I72V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2903051 7562369 JTY_2637 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645686.1 2902551 D 561275 CDS YP_002645687.1 224991000 7561407 complement(2903068..2903508) 1 NC_012207.1 transmembrane protein 2903508 7561407 JTY_2638 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645687.1 2903068 R 561275 CDS YP_002645688.1 224991001 7561408 2903655..2904332 1 NC_012207.1 hypothetical protein 2904332 7561408 JTY_2639 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645688.1 2903655 D 561275 CDS YP_002645689.1 224991002 7561409 complement(2904317..2904670) 1 NC_012207.1 hypothetical protein 2904670 7561409 JTY_2640 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645689.1 2904317 R 561275 CDS YP_002645690.1 224991003 7561410 complement(2904683..2905108) 1 NC_012207.1 transmembrane protein 2905108 7561410 JTY_2641 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645690.1 2904683 R 561275 CDS YP_002645691.1 224991004 7561411 complement(2905105..2905776) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 3 bp deletion (GGG-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (223 aa versus 224 aa) due to deletion of 1aa after position 194; transcriptional regulatory protein 2905776 7561411 JTY_2642 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645691.1 2905105 R 561275 CDS YP_002645692.1 224991005 7561412 2905854..2906675 1 NC_012207.1 methyltransferase 2906675 7561412 JTY_2643 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase YP_002645692.1 2905854 D 561275 CDS YP_002645693.1 224991006 7561413 2906811..2907704 1 NC_012207.1 hypothetical protein 2907704 TB31.7 7561413 TB31.7 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645693.1 2906811 D 561275 CDS YP_002645694.1 224991007 7561834 complement(2907707..2908525) 1 NC_012207.1 hypothetical protein 2908525 7561834 JTY_2645 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645694.1 2907707 R 561275 CDS YP_002645695.1 224991008 7561414 complement(2908540..2909721) 1 NC_012207.1 transmembrane alanine and leucine rich protein 2909721 7561414 JTY_2646 Mycobacterium bovis BCG str. Tokyo 172 transmembrane alanine and leucine rich protein YP_002645695.1 2908540 R 561275 CDS YP_002645696.1 224991009 7561415 complement(2909780..2910211) 1 NC_012207.1 hypothetical protein 2910211 7561415 JTY_2647 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645696.1 2909780 R 561275 CDS YP_002645697.1 224991010 7561416 complement(2910725..2911966) 1 NC_012207.1 Differs from Rv2627c by 1aa, G104R in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2911966 7561416 JTY_2648 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645697.1 2910725 R 561275 CDS YP_002645698.1 224991011 7561417 2912276..2912638 1 NC_012207.1 Differs from Rv2628 by 1aa, L59S, and from Mb2661 by 1aa, P68R in BCG Pasteur and BCG Tokyo; hypothetical protein 2912638 7561417 JTY_2649 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645698.1 2912276 D 561275 CDS YP_002645699.1 224991012 7561418 2912985..2914109 1 NC_012207.1 hypothetical protein 2914109 7561418 JTY_2650 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645699.1 2912985 D 561275 CDS YP_002645700.1 224991013 7561419 2914111..2914650 1 NC_012207.1 hypothetical protein 2914650 7561419 JTY_2651 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645700.1 2914111 D 561275 CDS YP_002645701.1 224991014 7561420 2914789..2916087 1 NC_012207.1 hypothetical protein 2916087 7561420 JTY_2652 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645701.1 2914789 D 561275 CDS YP_002645702.1 224991015 7561421 complement(2916126..2916407) 1 NC_012207.1 hypothetical protein 2916407 7561421 JTY_2653 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645702.1 2916126 R 561275 CDS YP_002645703.1 224991016 7561422 complement(2916552..2917037) 1 NC_012207.1 hypothetical protein 2917037 7561422 JTY_2654 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645703.1 2916552 R 561275 CDS YP_002645704.1 224991017 7561423 complement(2917322..2919724) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, an in-frame insertion of 66 bp, leads to a longer product compared to Mycobacterium bovis and Mycobacterium tuberculosis strain H37Rv (800 aa versus 778 aa); PE-PGRS family protein 2919724 PE_PGRS46 7561423 PE_PGRS46 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002645704.1 2917322 R 561275 CDS YP_002645705.1 224991018 7562371 2919753..2919995 1 NC_012207.1 hypothetical protein 2919995 7562371 JTY_2656 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645705.1 2919753 D 561275 CDS YP_002645706.1 224991019 7561424 2919996..2920673 1 NC_012207.1 hypothetical protein 2920673 7561424 JTY_2657 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645706.1 2919996 D 561275 CDS YP_002645707.1 224991020 7561425 2920869..2921525 1 NC_012207.1 transmembrane protein 2921525 dedA 7561425 dedA Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645707.1 2920869 D 561275 CDS YP_002645708.1 224991021 7561474 2921688..2922134 1 NC_012207.1 hypothetical protein 2922134 7561474 JTY_2659 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645708.1 2921688 D 561275 CDS YP_002645709.1 224991022 7561426 complement(2922309..2922641) 1 NC_012207.1 hypothetical protein 2922641 7561426 JTY_2660 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645709.1 2922309 R 561275 CDS YP_002645710.1 224991023 7561427 complement(2922761..2923120) 1 NC_012207.1 probably ArsR-family; transcriptional regulatory protein 2923120 7561427 JTY_2661 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645710.1 2922761 R 561275 CDS YP_002645711.1 224991024 7561428 2923222..2923680 1 NC_012207.1 cadmium inducible protein 2923680 cadI 7561428 cadI Mycobacterium bovis BCG str. Tokyo 172 cadmium inducible protein YP_002645711.1 2923222 D 561275 CDS YP_002645712.1 224991025 7562079 2923816..2924196 1 NC_012207.1 probably ArsR-family; transcriptional regulatory protein 2924196 7562079 JTY_2663 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645712.1 2923816 D 561275 CDS YP_002645713.1 224991026 7561429 2924193..2925689 1 NC_012207.1 Differs from Rv2643 by 1 aa A455V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; arsenic-transport integral membrane protein 2925689 arsC 7561429 arsC Mycobacterium bovis BCG str. Tokyo 172 arsenic-transport integral membrane protein YP_002645713.1 2924193 D 561275 CDS YP_002645714.1 224991027 7562038 complement(2925816..2926133) 1 NC_012207.1 hypothetical protein 2926133 7562038 JTY_2665 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645714.1 2925816 R 561275 CDS YP_002645715.1 224991028 7561679 complement(2927270..2927491) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 10982 bp deletion (RD11 region) leads to deletion of genes between Rv2645 and Rv2659c compared to Mycobacterium tuberculosis strain H37Rv; hypothetical protein 2927491 7561679 JTY_2666 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645715.1 2927270 R 561275 CDS YP_002645716.1 224991029 7561431 complement(2927488..2927877) 1 NC_012207.1 hypothetical protein 2927877 7561431 JTY_2667 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645716.1 2927488 R 561275 CDS YP_002645717.1 224991030 7561432 2927783..2928055 1 NC_012207.1 hypothetical protein 2928055 7561432 JTY_2668 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645717.1 2927783 D 561275 CDS YP_002645718.1 224991031 7561433 2928154..2928387 1 NC_012207.1 hypothetical protein 2928387 7561433 JTY_2669 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645718.1 2928154 D 561275 CDS YP_002645719.1 224991032 7561434 2928398..2928652 1 NC_012207.1 hypothetical protein 2928652 7561434 JTY_2670 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645719.1 2928398 D 561275 CDS YP_002645722.1 224991033 7561435 2929372..2930175 1 NC_012207.1 transposase for insertion sequence element IS1081 2930175 7561435 JTY_2673 Mycobacterium bovis BCG str. Tokyo 172 transposase for insertion sequence element IS1081 YP_002645722.1 2929372 D 561275 CDS YP_002645723.1 224991034 7561436 2930197..2930955 1 NC_012207.1 ATP-dependent protease ATP-binding subunit 2930955 clpX' 7561436 clpX' Mycobacterium bovis BCG str. Tokyo 172 ATP-dependent protease ATP-binding subunit YP_002645723.1 2930197 D 561275 CDS YP_002645724.1 224991035 7562113 2931034..2931555 1 NC_012207.1 Differs from Rv2668 by 2aa R3H and K162E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; exported alanine and valine rich protein 2931555 7562113 JTY_2675 Mycobacterium bovis BCG str. Tokyo 172 exported alanine and valine rich protein YP_002645724.1 2931034 D 561275 CDS YP_002645725.1 224991036 7561437 2931584..2932054 1 NC_012207.1 hypothetical protein 2932054 7561437 JTY_2676 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645725.1 2931584 D 561275 CDS YP_002645726.1 224991037 7561438 complement(2932032..2933141) 1 NC_012207.1 hypothetical protein 2933141 7561438 JTY_2677 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645726.1 2932032 R 561275 CDS YP_002645727.1 224991038 7561439 2933140..2933916 1 NC_012207.1 hypothetical protein 2933916 ribD 7561439 ribD Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645727.1 2933140 D 561275 CDS YP_002645728.1 224991039 7561574 2933983..2935569 1 NC_012207.1 Differs from Rv2672 by 1aa D317H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; protease 2935569 7561574 JTY_2679 Mycobacterium bovis BCG str. Tokyo 172 protease YP_002645728.1 2933983 D 561275 CDS YP_002645729.1 224991040 7561440 2935592..2936893 1 NC_012207.1 transmembrane protein 2936893 7561440 JTY_2680 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645729.1 2935592 D 561275 CDS YP_002645730.1 224991041 7561441 2937062..2937472 1 NC_012207.1 hypothetical protein 2937472 7561441 JTY_2681 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645730.1 2937062 D 561275 CDS YP_002645731.1 224991042 7561442 complement(2937540..2938292) 1 NC_012207.1 hypothetical protein 2938292 7561442 JTY_2682 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645731.1 2937540 R 561275 CDS YP_002645732.1 224991043 7561443 complement(2938289..2938984) 1 NC_012207.1 hypothetical protein 2938984 7561443 JTY_2683 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645732.1 2938289 R 561275 CDS YP_002645733.1 224991044 7561444 complement(2938990..2940348) 1 NC_012207.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX; protoporphyrinogen oxidase 2940348 hemY 7561444 hemY Mycobacterium bovis BCG str. Tokyo 172 protoporphyrinogen oxidase YP_002645733.1 2938990 R 561275 CDS YP_002645734.1 224991045 7563305 complement(2940345..2941418) 1 NC_012207.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 2941418 hemE 7563305 hemE Mycobacterium bovis BCG str. Tokyo 172 uroporphyrinogen decarboxylase YP_002645734.1 2940345 R 561275 CDS YP_002645735.1 224991046 7563301 2941471..2942301 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2942301 7563301 JTY_2686 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002645735.1 2941471 D 561275 CDS YP_002645736.1 224991047 7561445 2942563..2943195 1 NC_012207.1 hypothetical protein 2943195 7561445 JTY_2687 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645736.1 2942563 D 561275 CDS YP_002645737.1 224991048 7561446 2943197..2944513 1 NC_012207.1 Differs from Rv2681 by 1aa V196A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical alanine rich protein 2944513 7561446 JTY_2688 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine rich protein YP_002645737.1 2943197 D 561275 CDS YP_002645738.1 224991049 7561447 complement(2944510..2946426) 1 NC_012207.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 2946426 dxs1 7561447 dxs1 Mycobacterium bovis BCG str. Tokyo 172 1-deoxy-D-xylulose-5-phosphate synthase YP_002645738.1 2944510 R 561275 CDS YP_002645739.1 224991050 7561520 2946570..2947067 1 NC_012207.1 Differs from Rv2683 by 1aa, S84L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2947067 7561520 JTY_2690 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645739.1 2946570 D 561275 CDS YP_002645740.1 224991051 7561448 2947072..2948361 1 NC_012207.1 arsenic-transport integral membrane protein 2948361 arsA 7561448 arsA Mycobacterium bovis BCG str. Tokyo 172 arsenic-transport integral membrane protein YP_002645740.1 2947072 D 561275 CDS YP_002645741.1 224991052 7564003 2948441..2949727 1 NC_012207.1 Differs from Rv2685 by 1aa, G378A and Mb2704, by 1aa, G393C in BCG Pasteur and BCG Tokyo; arsenic-transport integral membrane protein 2949727 arsB1 7564003 arsB1 Mycobacterium bovis BCG str. Tokyo 172 arsenic-transport integral membrane protein YP_002645741.1 2948441 D 561275 CDS YP_002645742.1 224991053 7562036 complement(2949738..2950496) 1 NC_012207.1 antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter 2950496 7562036 JTY_2693 Mycobacterium bovis BCG str. Tokyo 172 antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter YP_002645742.1 2949738 R 561275 CDS YP_002645743.1 224991054 7561449 complement(2950493..2951206) 1 NC_012207.1 antibiotic-transport integral membrane leucine and valine rich protein ABC transporter 2951206 7561449 JTY_2694 Mycobacterium bovis BCG str. Tokyo 172 antibiotic-transport integral membrane leucine and valine rich protein ABC transporter YP_002645743.1 2950493 R 561275 CDS YP_002645744.1 224991055 7562282 complement(2951203..2952108) 1 NC_012207.1 Differs from Rv2688c by 1aa, T156P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; antibiotic-transport ATP-binding protein ABC transporter 2952108 7562282 JTY_2695 Mycobacterium bovis BCG str. Tokyo 172 antibiotic-transport ATP-binding protein ABC transporter YP_002645744.1 2951203 R 561275 CDS YP_002645745.1 224991056 7562283 complement(2952303..2953520) 1 NC_012207.1 hypothetical alanine and valine and glycine rich protein 2953520 7562283 JTY_2696 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine and valine and glycine rich protein YP_002645745.1 2952303 R 561275 CDS YP_002645746.1 224991057 7562284 complement(2953676..2955667) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (t-c) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (663 aa versus 657aa); integral membrane alanine and valine and leucine rich protein 2955667 7562284 JTY_2697 Mycobacterium bovis BCG str. Tokyo 172 integral membrane alanine and valine and leucine rich protein YP_002645746.1 2953676 R 561275 CDS YP_002645747.1 224991058 7562285 2955802..2956485 1 NC_012207.1 Differs from Rv2691 by 1aa, A117T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; trk system potassium uptake protein 2956485 ceoB 7562285 ceoB Mycobacterium bovis BCG str. Tokyo 172 trk system potassium uptake protein YP_002645747.1 2955802 D 561275 CDS YP_002645748.1 224991059 7562095 2956482..2957144 1 NC_012207.1 Differs from Rv2692 by 1aa, V133I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; trk system potassium uptake protein 2957144 ceoC 7562095 ceoC Mycobacterium bovis BCG str. Tokyo 172 trk system potassium uptake protein YP_002645748.1 2956482 D 561275 CDS YP_002645749.1 224991060 7562096 complement(2957155..2957826) 1 NC_012207.1 integral membrane alanine and leucine rich protein 2957826 7562096 JTY_2700 Mycobacterium bovis BCG str. Tokyo 172 integral membrane alanine and leucine rich protein YP_002645749.1 2957155 R 561275 CDS YP_002645750.1 224991061 7562286 complement(2957857..2958225) 1 NC_012207.1 Differs from Rv2694c by 1aa, S68R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2958225 7562286 JTY_2701 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645750.1 2957857 R 561275 CDS YP_002645751.1 224991062 7562287 2958374..2959081 1 NC_012207.1 hypothetical alanine rich protein 2959081 7562287 JTY_2702 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine rich protein YP_002645751.1 2958374 D 561275 CDS YP_002645752.1 224991063 7562288 complement(2959287..2960066) 1 NC_012207.1 Differs from Rv2696c by 1aa, N164D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical alanine and glycine and valine rich protein 2960066 7562288 JTY_2703 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine and glycine and valine rich protein YP_002645752.1 2959287 R 561275 CDS YP_002645753.1 224991064 7562289 complement(2960141..2960605) 1 NC_012207.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 2960605 dut 7562289 dut Mycobacterium bovis BCG str. Tokyo 172 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_002645753.1 2960141 R 561275 CDS YP_002645754.1 224991065 7561518 2960631..2961116 1 NC_012207.1 alanine rich transmembrane protein 2961116 7561518 JTY_2705 Mycobacterium bovis BCG str. Tokyo 172 alanine rich transmembrane protein YP_002645754.1 2960631 D 561275 CDS YP_002645755.1 224991066 7562290 complement(2961121..2961423) 1 NC_012207.1 hypothetical protein 2961423 7562290 JTY_2706 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645755.1 2961121 R 561275 CDS YP_002645756.1 224991067 7562291 2961661..2962311 1 NC_012207.1 alanine rich protein 2962311 7562291 JTY_2707 Mycobacterium bovis BCG str. Tokyo 172 alanine rich protein YP_002645756.1 2961661 D 561275 CDS YP_002645757.1 224991068 7562292 complement(2962321..2963193) 1 NC_012207.1 extragenic suppressor protein 2963193 suhB 7562292 suhB Mycobacterium bovis BCG str. Tokyo 172 extragenic suppressor protein YP_002645757.1 2962321 R 561275 CDS YP_002645758.1 224991069 7561819 2963316..2964113 1 NC_012207.1 Differs from Rv2702 by 1aa, T203I in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; polyphosphate glucokinase 2964113 ppgK 7561819 ppgK Mycobacterium bovis BCG str. Tokyo 172 polyphosphate glucokinase YP_002645758.1 2963316 D 561275 CDS YP_002645759.1 224991070 7560805 2964293..2965879 1 NC_012207.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RNA polymerase sigma factor 2965879 sigA 7560805 sigA Mycobacterium bovis BCG str. Tokyo 172 RNA polymerase sigma factor YP_002645759.1 2964293 D 561275 CDS YP_002645760.1 224991071 7560789 2965916..2966344 1 NC_012207.1 hypothetical protein 2966344 7560789 JTY_2711 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645760.1 2965916 D 561275 CDS YP_002645761.1 224991072 7562293 complement(2966272..2966661) 1 NC_012207.1 hypothetical protein 2966661 7562293 JTY_2712 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645761.1 2966272 R 561275 CDS YP_002645762.1 224991073 7562294 complement(2966658..2966915) 1 NC_012207.1 hypothetical protein 2966915 7562294 JTY_2713 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645762.1 2966658 R 561275 CDS YP_002645763.1 224991074 7562295 2967031..2968005 1 NC_012207.1 transmembrane alanine and leucine rich protein 2968005 7562295 JTY_2714 Mycobacterium bovis BCG str. Tokyo 172 transmembrane alanine and leucine rich protein YP_002645763.1 2967031 D 561275 CDS YP_002645764.1 224991075 7562296 complement(2968006..2968254) 1 NC_012207.1 hypothetical protein 2968254 7562296 JTY_2715 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645764.1 2968006 R 561275 CDS YP_002645765.1 224991076 7562297 2968297..2968743 1 NC_012207.1 Differs from Rv2709 by 1aa, S35T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 2968743 7562297 JTY_2716 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645765.1 2968297 D 561275 CDS YP_002645766.1 224991077 7562298 2968919..2969890 1 NC_012207.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase; RNA polymerase sigma factor SigB 2969890 sigB 7562298 sigB Mycobacterium bovis BCG str. Tokyo 172 RNA polymerase sigma factor SigB YP_002645766.1 2968919 D 561275 CDS YP_002645767.1 224991078 7560790 2970023..2970715 1 NC_012207.1 iron-dependent repressor and activator 2970715 ideR 7560790 ideR Mycobacterium bovis BCG str. Tokyo 172 iron-dependent repressor and activator YP_002645767.1 2970023 D 561275 CDS YP_002645768.1 224991079 7563342 complement(2970728..2971786) 1 NC_012207.1 hypothetical protein 2971786 7563342 JTY_2719 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645768.1 2970728 R 561275 CDS YP_002645769.1 224991080 7562299 2971899..2973305 1 NC_012207.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 2973305 sthA 7562299 sthA Mycobacterium bovis BCG str. Tokyo 172 soluble pyridine nucleotide transhydrogenase YP_002645769.1 2971899 D 561275 CDS YP_002645770.1 224991081 7561811 2973523..2974497 1 NC_012207.1 Differs from Rv2714 by 2aa, W181S, A245V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical alanine and leucine rich protein 2974497 7561811 JTY_2721 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine and leucine rich protein YP_002645770.1 2973523 D 561275 CDS YP_002645771.1 224991082 7562300 2974556..2975581 1 NC_012207.1 hydrolase 2975581 7562300 JTY_2722 Mycobacterium bovis BCG str. Tokyo 172 hydrolase YP_002645771.1 2974556 D 561275 CDS YP_002645772.1 224991083 7562301 2975630..2976316 1 NC_012207.1 hypothetical protein 2976316 7562301 JTY_2723 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645772.1 2975630 D 561275 CDS YP_002645773.1 224991084 7562302 complement(2976325..2976819) 1 NC_012207.1 hypothetical protein 2976819 7562302 JTY_2724 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645773.1 2976325 R 561275 CDS YP_002645774.1 224991085 7562303 complement(2976871..2977335) 1 NC_012207.1 transcriptional regulator NrdR 2977335 nrdR 7562303 nrdR Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulator NrdR YP_002645774.1 2976871 R 561275 CDS YP_002645775.1 224991086 7562304 complement(2977498..2977995) 1 NC_012207.1 Differs from Rv2719c by 1aa, H124Y in Mycobacteium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2977995 7562304 JTY_2726 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645775.1 2977498 R 561275 CDS YP_002645776.1 224991087 7562305 2978303..2978956 1 NC_012207.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 2978956 lexA 7562305 lexA Mycobacterium bovis BCG str. Tokyo 172 LexA repressor YP_002645776.1 2978303 D 561275 CDS YP_002645777.1 224991088 7562823 complement(2978978..2981077) 1 NC_012207.1 Differs from Rv2721c and Mb2740c by 2aa, S251G, A326T in BCG Pasteur and BCG Tokyo; transmembrane alanine and glycine rich protein 2981077 7562823 JTY_2728 Mycobacterium bovis BCG str. Tokyo 172 transmembrane alanine and glycine rich protein YP_002645777.1 2978978 R 561275 CDS YP_002645778.1 224991089 7562306 2981093..2981341 1 NC_012207.1 hypothetical protein 2981341 7562306 JTY_2729 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645778.1 2981093 D 561275 CDS YP_002645779.1 224991090 7562307 2981367..2982560 1 NC_012207.1 integral membrane protein 2982560 7562307 JTY_2730 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002645779.1 2981367 D 561275 CDS YP_002645780.1 224991091 7562308 complement(2982589..2983749) 1 NC_012207.1 Differs from Rv2724c by 1aa, T127I, and from Mb2743c by 1aa, P33A in BCG Pasteur and BCG Tokyo; acyl-CoA dehydrogenase 2983749 fadE20 7562308 fadE20 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002645780.1 2982589 R 561275 CDS YP_002645781.1 224991092 7563369 complement(2983885..2985372) 1 NC_012207.1 Differs from Rv2725c and Mb2744c by 1aa, D218G in BCG Pasteur and BCG Tokyo; GTP-binding protein 2985372 hflX 7563369 hflX Mycobacterium bovis BCG str. Tokyo 172 GTP-binding protein YP_002645781.1 2983885 R 561275 CDS YP_002645782.1 224991093 7563307 complement(2985389..2986258) 1 NC_012207.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 2986258 dapF 7563307 dapF Mycobacterium bovis BCG str. Tokyo 172 diaminopimelate epimerase YP_002645782.1 2985389 R 561275 CDS YP_002645783.1 224991094 7561469 complement(2986283..2987227) 1 NC_012207.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 2987227 miaA 7561469 miaA Mycobacterium bovis BCG str. Tokyo 172 tRNA delta(2)-isopentenylpyrophosphate transferase YP_002645783.1 2986283 R 561275 CDS YP_002645784.1 224991095 7564473 complement(2987224..2987919) 1 NC_012207.1 hypothetical alanine rich protein 2987919 7564473 JTY_2735 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine rich protein YP_002645784.1 2987224 R 561275 CDS YP_002645785.1 224991096 7562309 complement(2988028..2988933) 1 NC_012207.1 Differs from Rv2729c by 3aa, L41F, E202A, V266A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane alanine and valine and leucine rich protein 2988933 7562309 JTY_2736 Mycobacterium bovis BCG str. Tokyo 172 integral membrane alanine and valine and leucine rich protein YP_002645785.1 2988028 R 561275 CDS YP_002645786.1 224991097 7562310 2989000..2989476 1 NC_012207.1 hypothetical protein 2989476 7562310 JTY_2737 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645786.1 2989000 D 561275 CDS YP_002645787.1 224991098 7562311 2989484..2990836 1 NC_012207.1 hypothetical alanine and arginine rich protein 2990836 7562311 JTY_2738 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine and arginine rich protein YP_002645787.1 2989484 D 561275 CDS YP_002645788.1 224991099 7562312 complement(2990833..2991447) 1 NC_012207.1 transmembrane protein 2991447 7562312 JTY_2739 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645788.1 2990833 R 561275 CDS YP_002645789.1 224991100 7562313 complement(2991444..2992982) 1 NC_012207.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 2992982 7562313 JTY_2740 Mycobacterium bovis BCG str. Tokyo 172 (dimethylallyl)adenosine tRNA methylthiotransferase YP_002645789.1 2991444 R 561275 CDS YP_002645790.1 224991101 7562314 2993279..2994133 1 NC_012207.1 hypothetical protein 2994133 7562314 JTY_2741 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645790.1 2993279 D 561275 CDS YP_002645791.1 224991102 7562315 complement(2994018..2995010) 1 NC_012207.1 hypothetical protein 2995010 7562315 JTY_2742 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645791.1 2994018 R 561275 CDS YP_002645792.1 224991103 7562316 complement(2995020..2995544) 1 NC_012207.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 2995544 recX 7562316 recX Mycobacterium bovis BCG str. Tokyo 172 recombination regulator RecX YP_002645792.1 2995020 R 561275 CDS YP_002645793.1 224991104 7561563 complement(2995510..2997882) 1 NC_012207.1 these RecA proteins contain inteins; catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; DNA recombination protein RecA 2997882 recA 7561563 recA Mycobacterium bovis BCG str. Tokyo 172 DNA recombination protein RecA YP_002645793.1 2995510 R 561275 CDS YP_002645794.1 224991105 7561553 2998077..2998250 1 NC_012207.1 hypothetical protein 2998250 7561553 JTY_2745 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645794.1 2998077 D 561275 CDS YP_002645795.1 224991106 7562317 complement(2998264..2998470) 1 NC_012207.1 hypothetical protein 2998470 7562317 JTY_2746 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645795.1 2998264 R 561275 CDS YP_002645796.1 224991107 7562318 complement(2998481..2999647) 1 NC_012207.1 alanine rich transferase 2999647 7562318 JTY_2747 Mycobacterium bovis BCG str. Tokyo 172 alanine rich transferase YP_002645796.1 2998481 R 561275 CDS YP_002645797.1 224991108 7562319 2999691..3000140 1 NC_012207.1 epoxide hydrolase 3000140 ephG 7562319 ephG Mycobacterium bovis BCG str. Tokyo 172 epoxide hydrolase YP_002645797.1 2999691 D 561275 CDS YP_002645799.1 224991110 7562373 3000416..3001690 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, deletions of a single base (t-*) and of 84 bp (H37Rv2.3054724-3054807-*) leads to a shorter product with a different 5' start compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Also has lost 174 bp compared to Mb2761; PE-PGRS family protein 3001690 PE_PGRS47 7562373 PE_PGRS47 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002645799.1 3000416 D 561275 CDS YP_002645800.1 224991111 7562372 complement(3001714..3001962) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2742c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a 23bp insertion splits Rv2742c into two parts; hypothetical arginine rich protein 3001962 7562372 JTY_2751 Mycobacterium bovis BCG str. Tokyo 172 hypothetical arginine rich protein YP_002645800.1 3001714 R 561275 CDS YP_002645801.1 224991112 7562320 complement(3001983..3002570) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2742c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a 23bp insertion splits Rv2742c into two parts; hypothetical arginine rich protein 3002570 7562320 JTY_2752 Mycobacterium bovis BCG str. Tokyo 172 hypothetical arginine rich protein YP_002645801.1 3001983 R 561275 CDS YP_002645802.1 224991113 7562321 complement(3002642..3003454) 1 NC_012207.1 membrane alanine rich protein 3003454 7562321 JTY_2753 Mycobacterium bovis BCG str. Tokyo 172 membrane alanine rich protein YP_002645802.1 3002642 R 561275 CDS YP_002645803.1 224991114 7562322 complement(3003473..3004285) 1 NC_012207.1 Differs from Mb2765c by 1aa, K153Q in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; conserved 35 kda alanine rich protein 3004285 35kd_ag 7562322 35kd_ag Mycobacterium bovis BCG str. Tokyo 172 conserved 35 kda alanine rich protein YP_002645803.1 3003473 R 561275 CDS YP_002645804.1 224991115 7564325 complement(3004415..3004753) 1 NC_012207.1 transcriptional regulatory protein 3004753 7564325 JTY_2755 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645804.1 3004415 R 561275 CDS YP_002645805.1 224991116 7562323 complement(3004824..3005453) 1 NC_012207.1 pgp synthase pgsA3 3005453 pgsA3 7562323 pgsA3 Mycobacterium bovis BCG str. Tokyo 172 pgp synthase pgsA3 YP_002645805.1 3004824 R 561275 CDS YP_002645806.1 224991117 7562403 3005484..3006008 1 NC_012207.1 catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis; N-acetylglutamate synthase 3006008 7562403 JTY_2757 Mycobacterium bovis BCG str. Tokyo 172 N-acetylglutamate synthase YP_002645806.1 3005484 D 561275 CDS YP_002645807.1 224991118 7562324 complement(3006077..3008728) 1 NC_012207.1 cell division transmembrane protein 3008728 ftsK 7562324 ftsK Mycobacterium bovis BCG str. Tokyo 172 cell division transmembrane protein YP_002645807.1 3006077 R 561275 CDS YP_002645808.1 224991119 7561878 3008727..3009041 1 NC_012207.1 hypothetical protein 3009041 7561878 JTY_2759 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645808.1 3008727 D 561275 CDS YP_002645809.1 224991120 7562325 3009038..3009856 1 NC_012207.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 3009856 7562325 JTY_2760 Mycobacterium bovis BCG str. Tokyo 172 3-ketoacyl-ACP reductase YP_002645809.1 3009038 D 561275 CDS YP_002645810.1 224991121 7562326 3009860..3010750 1 NC_012207.1 hypothetical protein 3010750 7562326 JTY_2761 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645810.1 3009860 D 561275 CDS YP_002645811.1 224991122 7562327 complement(3010737..3012413) 1 NC_012207.1 hypothetical protein 3012413 7562327 JTY_2762 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645811.1 3010737 R 561275 CDS YP_002645812.1 224991123 7562328 complement(3012444..3013346) 1 NC_012207.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 3013346 dapA 7562328 dapA Mycobacterium bovis BCG str. Tokyo 172 dihydrodipicolinate synthase YP_002645812.1 3012444 R 561275 CDS YP_002645813.1 224991124 7561466 complement(3013415..3014167) 1 NC_012207.1 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase 3014167 thyX 7561466 thyX Mycobacterium bovis BCG str. Tokyo 172 FAD-dependent thymidylate synthase YP_002645813.1 3013415 R 561275 CDS YP_002645814.1 224991125 7561858 complement(3014411..3014686) 1 NC_012207.1 type I restriction/modification system specificity determinant 3014686 hsdS' 7561858 hsdS' Mycobacterium bovis BCG str. Tokyo 172 type I restriction/modification system specificity determinant YP_002645814.1 3014411 R 561275 CDS YP_002645815.1 224991126 7563327 complement(3014683..3016305) 1 NC_012207.1 Differs from Rv2756c by 1aa, P306L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; type I restriction/modification system DNA methylase 3016305 hsdM 7563327 hsdM Mycobacterium bovis BCG str. Tokyo 172 type I restriction/modification system DNA methylase YP_002645815.1 3014683 R 561275 CDS YP_002645816.1 224991127 7563325 complement(3016392..3016808) 1 NC_012207.1 hypothetical protein 3016808 7563325 JTY_2767 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645816.1 3016392 R 561275 CDS YP_002645817.1 224991128 7562329 complement(3016805..3017071) 1 NC_012207.1 hypothetical protein 3017071 7562329 JTY_2768 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645817.1 3016805 R 561275 CDS YP_002645818.1 224991129 7562330 complement(3017097..3017492) 1 NC_012207.1 hypothetical protein 3017492 7562330 JTY_2769 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645818.1 3017097 R 561275 CDS YP_002645819.1 224991130 7562331 complement(3017489..3017758) 1 NC_012207.1 hypothetical protein 3017758 7562331 JTY_2770 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645819.1 3017489 R 561275 CDS YP_002645820.1 224991131 7562332 complement(3017768..3018862) 1 NC_012207.1 type I restriction/modification system specificity determinant 3018862 hsdS 7562332 hsdS Mycobacterium bovis BCG str. Tokyo 172 type I restriction/modification system specificity determinant YP_002645820.1 3017768 R 561275 CDS YP_002645821.1 224991132 7563326 complement(3018859..3019131) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2762c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (C-T) splits Rv2762c into 2 parts; hypothetical protein 3019131 7563326 JTY_2772 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645821.1 3018859 R 561275 CDS YP_002645822.1 224991133 7562333 complement(3019147..3019278) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv2762c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (C-T) splits Rv2762c into 2 parts; hypothetical protein 3019278 7562333 JTY_2773 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645822.1 3019147 R 561275 CDS YP_002645823.1 224991134 7562334 complement(3019352..3019831) 1 NC_012207.1 dihydrofolate reductase 3019831 dfrA 7562334 dfrA Mycobacterium bovis BCG str. Tokyo 172 dihydrofolate reductase YP_002645823.1 3019352 R 561275 CDS YP_002645824.1 224991135 7561490 complement(3019902..3020693) 1 NC_012207.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 3020693 thyA 7561490 thyA Mycobacterium bovis BCG str. Tokyo 172 thymidylate synthase YP_002645824.1 3019902 R 561275 CDS YP_002645825.1 224991136 7561857 3020858..3021595 1 NC_012207.1 Differs from Rv2765 and Mb2787 by 1aa, I129M in BCG Pasteur and BCG Tokyo; alanine rich hydrolase 3021595 7561857 JTY_2776 Mycobacterium bovis BCG str. Tokyo 172 alanine rich hydrolase YP_002645825.1 3020858 D 561275 CDS YP_002645826.1 224991137 7562335 complement(3021810..3022592) 1 NC_012207.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 3022592 fabG 7562335 fabG Mycobacterium bovis BCG str. Tokyo 172 3-ketoacyl-ACP reductase YP_002645826.1 3021810 R 561275 CDS YP_002645827.1 224991138 7562898 complement(3022589..3022942) 1 NC_012207.1 Differs from Rv2767c and Mb2789c by 1aa, L26S in BCG Pasteur and BCG Tokyo; hypothetical protein 3022942 7562898 JTY_2778 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645827.1 3022589 R 561275 CDS YP_002645828.1 224991139 7562336 complement(3023116..3024300) 1 NC_012207.1 Differs from Rv2768c by 1aa, R263P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PPE family protein 3024300 PPE43 7562336 PPE43 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002645828.1 3023116 R 561275 CDS YP_002645829.1 224991140 7562181 complement(3024380..3025207) 1 NC_012207.1 Differs from Rv2769c by 2aa, S54P, M270V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PE family protein 3025207 PE27 7562181 PE27 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002645829.1 3024380 R 561275 CDS YP_002645830.1 224991141 7561727 complement(3025531..3026679) 1 NC_012207.1 Differs from Rv2770c by 1aa, S194F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PPE family protein 3026679 PPE44 7561727 PPE44 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002645830.1 3025531 R 561275 CDS YP_002645831.1 224991142 7562182 complement(3026803..3027255) 1 NC_012207.1 Differs from Rv2771c by 1aa, P80L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 3027255 7562182 JTY_2782 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645831.1 3026803 R 561275 CDS YP_002645832.1 224991143 7562337 complement(3027341..3027814) 1 NC_012207.1 transmembrane protein 3027814 7562337 JTY_2783 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645832.1 3027341 R 561275 CDS YP_002645833.1 224991144 7562338 complement(3027826..3028563) 1 NC_012207.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 3028563 dapB 7562338 dapB Mycobacterium bovis BCG str. Tokyo 172 dihydrodipicolinate reductase YP_002645833.1 3027826 R 561275 CDS YP_002645834.1 224991145 7561467 complement(3028574..3028978) 1 NC_012207.1 hypothetical protein 3028978 7561467 JTY_2785 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645834.1 3028574 R 561275 CDS YP_002645835.1 224991146 7562339 3029131..3029592 1 NC_012207.1 hypothetical protein 3029592 7562339 JTY_2786 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645835.1 3029131 D 561275 CDS YP_002645836.1 224991147 7562340 complement(3029596..3030525) 1 NC_012207.1 oxidoreductase 3030525 7562340 JTY_2787 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002645836.1 3029596 R 561275 CDS YP_002645837.1 224991148 7562341 complement(3030707..3031777) 1 NC_012207.1 hypothetical protein 3031777 7562341 JTY_2788 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645837.1 3030707 R 561275 CDS YP_002645838.1 224991149 7562342 complement(3031935..3032405) 1 NC_012207.1 hypothetical protein 3032405 7562342 JTY_2789 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645838.1 3031935 R 561275 CDS YP_002645839.1 224991150 7562343 complement(3032437..3032976) 1 NC_012207.1 In Mycobacterium bovis, a 24 bp deletion leads to a shorter product compared to its homolog in Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv (171 aa versus 179 aa) Differs from Rv2779c by 1aa, I9M, and 8 aa longer than Mb2801c; probably lrp/AsnC-family; transcriptional regulatory protein 3032976 7562343 JTY_2790 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645839.1 3032437 R 561275 CDS YP_002645840.1 224991151 7562344 3033042..3033440 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and in Mycobacterium bovis, a frameshift due to a single base deletion (A-*) splits ald into 2 parts, alda and aldb; L-alanine dehydrogenase 3033440 ald_a 7562344 ald_a Mycobacterium bovis BCG str. Tokyo 172 L-alanine dehydrogenase YP_002645840.1 3033042 D 561275 CDS YP_002645841.1 224991152 7563961 3033437..3034156 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and in Mycobacterium bovis, a frameshift due to a single base deletion (A-*) splits ald into 2 parts, alda and aldb; L-alanine dehydrogenase 3034156 aldB 7563961 aldB Mycobacterium bovis BCG str. Tokyo 172 L-alanine dehydrogenase YP_002645841.1 3033437 D 561275 CDS YP_002645842.1 224991153 7563959 complement(3034171..3035205) 1 NC_012207.1 alanine rich oxidoreductase 3035205 7563959 JTY_2793 Mycobacterium bovis BCG str. Tokyo 172 alanine rich oxidoreductase YP_002645842.1 3034171 R 561275 CDS YP_002645843.1 224991154 7562345 complement(3035266..3036582) 1 NC_012207.1 zinc protease 3036582 pepR 7562345 pepR Mycobacterium bovis BCG str. Tokyo 172 zinc protease YP_002645843.1 3035266 R 561275 CDS YP_002645844.1 224991155 7561747 complement(3036560..3038818) 1 NC_012207.1 polynucleotide phosphorylase 3038818 gpsI 7561747 gpsI Mycobacterium bovis BCG str. Tokyo 172 polynucleotide phosphorylase YP_002645844.1 3036560 R 561275 CDS YP_002645845.1 224991156 7563278 complement(3039172..3039687) 1 NC_012207.1 lipoprotein 3039687 lppU 7563278 lppU Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645845.1 3039172 R 561275 CDS YP_002645846.1 224991157 7560487 complement(3039700..3039969) 1 NC_012207.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 3039969 rpsO 7560487 rpsO Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S15 YP_002645846.1 3039700 R 561275 CDS YP_002645847.1 224991158 7560743 complement(3040126..3041121) 1 NC_012207.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 3041121 ribF 7560743 ribF Mycobacterium bovis BCG str. Tokyo 172 bifunctional riboflavin kinase/FMN adenylyltransferase YP_002645847.1 3040126 R 561275 CDS YP_002645848.1 224991159 7561575 3041332..3043095 1 NC_012207.1 Differs from Rv2787 and Mb2810 by 1aa, P78T; hypothetical alanine rich protein 3043095 7561575 JTY_2799 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine rich protein YP_002645848.1 3041332 D 561275 CDS YP_002645849.1 224991160 7562346 3043180..3043866 1 NC_012207.1 Differs from Rv2788 by 1aa, A137D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional repressor 3043866 sirR 7562346 sirR Mycobacterium bovis BCG str. Tokyo 172 transcriptional repressor YP_002645849.1 3043180 D 561275 CDS YP_002645850.1 224991161 7561799 complement(3043927..3045159) 1 NC_012207.1 acyl-CoA dehydrogenase 3045159 fadE21 7561799 fadE21 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002645850.1 3043927 R 561275 CDS YP_002645851.1 224991162 7563370 complement(3045185..3046390) 1 NC_012207.1 lipid-transfer protein 3046390 ltp1 7563370 ltp1 Mycobacterium bovis BCG str. Tokyo 172 lipid-transfer protein YP_002645851.1 3045185 R 561275 CDS YP_002645852.1 224991163 7560538 complement(3046423..3047802) 1 NC_012207.1 transposase 3047802 7560538 JTY_2803 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002645852.1 3046423 R 561275 CDS YP_002645853.1 224991164 7562347 complement(3047802..3048383) 1 NC_012207.1 Differs from Mb2815c by 2aa, A17V, T80E in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; resolvase 3048383 7562347 JTY_2804 Mycobacterium bovis BCG str. Tokyo 172 resolvase YP_002645853.1 3047802 R 561275 CDS YP_002645854.1 224991165 7562348 complement(3048585..3049481) 1 NC_012207.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 3049481 truB 7562348 truB Mycobacterium bovis BCG str. Tokyo 172 tRNA pseudouridine synthase B YP_002645854.1 3048585 R 561275 CDS YP_002645855.1 224991166 7561637 complement(3049478..3050161) 1 NC_012207.1 Differs from Rv2794c by 1aa, V87M in Mycobacterium tuberculosis CDC1551 in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3050161 7561637 JTY_2806 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645855.1 3049478 R 561275 CDS YP_002645856.1 224991167 7562349 complement(3050158..3051132) 1 NC_012207.1 hypothetical protein 3051132 7562349 JTY_2807 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645856.1 3050158 R 561275 CDS YP_002645857.1 224991168 7562350 complement(3051277..3051840) 1 NC_012207.1 Differs from Rv2796c by 1aa, F159C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 3051840 lppV 7562350 lppV Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002645857.1 3051277 R 561275 CDS YP_002645858.1 224991169 7560488 complement(3051840..3053528) 1 NC_012207.1 hypothetical protein 3053528 7560488 JTY_2809 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645858.1 3051840 R 561275 CDS YP_002645859.1 224991170 7562351 complement(3053532..3053858) 1 NC_012207.1 hypothetical protein 3053858 7562351 JTY_2810 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645859.1 3053532 R 561275 CDS YP_002645860.1 224991171 7562352 3053989..3054618 1 NC_012207.1 In Mycobacterium bovis, a 3 bp insertion (*-GGT) leads to a slightly longer product compared to its homolog in Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv (210 aa versus 209 aa); hypothetical protein 3054618 7562352 JTY_2811 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645860.1 3053989 D 561275 CDS YP_002645861.1 224991172 7562353 3054637..3056286 1 NC_012207.1 hydrolase 3056286 7562353 JTY_2812 Mycobacterium bovis BCG str. Tokyo 172 hydrolase YP_002645861.1 3054637 D 561275 CDS YP_002645862.1 224991173 7562354 complement(3056388..3056744) 1 NC_012207.1 hypothetical protein 3056744 7562354 JTY_2813 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645862.1 3056388 R 561275 CDS YP_002645863.1 224991174 7562355 complement(3057001..3058044) 1 NC_012207.1 hypothetical arginine and alanine rich protein 3058044 7562355 JTY_2814 Mycobacterium bovis BCG str. Tokyo 172 hypothetical arginine and alanine rich protein YP_002645863.1 3057001 R 561275 CDS YP_002645864.1 224991175 7562356 3058043..3058510 1 NC_012207.1 hypothetical protein 3058510 7562356 JTY_2815 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645864.1 3058043 D 561275 CDS YP_002645865.1 224991176 7562357 complement(3058686..3059315) 1 NC_012207.1 Differs from Rv2804c by 2aa, T58A, V74A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3059315 7562357 JTY_2816 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645865.1 3058686 R 561275 CDS YP_002645866.1 224991177 7562358 3059088..3059492 1 NC_012207.1 Differs from Rv2805 by 1aa, D4G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3059492 7562358 JTY_2817 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645866.1 3059088 D 561275 CDS YP_002645867.1 224991178 7562359 3059489..3059680 1 NC_012207.1 hypothetical protein 3059680 7562359 JTY_2818 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645867.1 3059489 D 561275 CDS YP_002645868.1 224991179 7562360 3059879..3061033 1 NC_012207.1 Differs from Rv2807 by 2aa, V72E, T349M, and from Mb2830 by 1aa, T349M in BCG Pasteur and BCG Tokyo; hypothetical protein 3061033 7562360 JTY_2819 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645868.1 3059879 D 561275 CDS YP_002645869.1 224991180 7562361 3061267..3061524 1 NC_012207.1 hypothetical protein 3061524 7562361 JTY_2820 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645869.1 3061267 D 561275 CDS YP_002645870.1 224991181 7562362 3061629..3061940 1 NC_012207.1 Differs from Rv2809 by 1aa, P46T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3061940 7562362 JTY_2821 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645870.1 3061629 D 561275 CDS YP_002645871.1 224991182 7563758 3062360..3062968 1 NC_012207.1 hypothetical protein 3062968 7563758 JTY_2823 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645871.1 3062360 D 561275 CDS YP_002645872.1 224991183 7563759 3063039..3064448 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, Rv2812 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (TG-*) splits Rv2812 into 2 parts, Mb2835 and Mb2836. Differs from Rv2812 by 1 aa, G395R; transposase 3064448 7563759 JTY_2824 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002645872.1 3063039 D 561275 CDS YP_002645873.1 224991184 7563760 3064445..3065257 1 NC_012207.1 Differs from Rv2813 by 1aa, V76I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3065257 7563760 JTY_2825 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645873.1 3064445 D 561275 CDS YP_002645874.1 224991185 7563761 complement(3066860..3067696) 1 NC_012207.1 transposase 3067696 7563761 JTY_2826 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002645874.1 3066860 R 561275 CDS YP_002645875.1 224991186 7563762 complement(3067795..3068121) 1 NC_012207.1 transposase 3068121 7563762 JTY_2827 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002645875.1 3067795 R 561275 CDS YP_002645876.1 224991187 7563763 complement(3070375..3070716) 1 NC_012207.1 hypothetical protein 3070716 7563763 JTY_2828 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645876.1 3070375 R 561275 CDS YP_002645877.1 224991188 7563764 complement(3070717..3071733) 1 NC_012207.1 hypothetical protein 3071733 7563764 JTY_2829 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645877.1 3070717 R 561275 CDS YP_002645878.1 224991189 7563766 complement(3071983..3072993) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (c-t) introduces a premature stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (336 aa versus 382 aa); hypothetical protein 3072993 7563766 JTY_2831 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645878.1 3071983 R 561275 CDS YP_002645879.1 224991190 7563767 complement(3072990..3074117) 1 NC_012207.1 hypothetical protein 3074117 7563767 JTY_2832 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645879.1 3072990 R 561275 CDS YP_002645880.1 224991191 7563768 complement(3074114..3075022) 1 NC_012207.1 hypothetical protein 3075022 7563768 JTY_2833 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645880.1 3074114 R 561275 CDS YP_002645881.1 224991192 7563769 complement(3075003..3075713) 1 NC_012207.1 hypothetical protein 3075713 7563769 JTY_2834 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645881.1 3075003 R 561275 CDS YP_002645882.1 224991193 7563770 complement(3075723..3076097) 1 NC_012207.1 hypothetical protein 3076097 7563770 JTY_2835 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645882.1 3075723 R 561275 CDS YP_002645883.1 224991194 7563771 complement(3076094..3078532) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 9 bp insertion (*-CGGCGATGT) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv; hypothetical protein 3078532 7563771 JTY_2836 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645883.1 3076094 R 561275 CDS YP_002645884.1 224991195 7563772 complement(3078529..3079473) 1 NC_012207.1 Differs from Mb2848c by 1aa H56P in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3079473 7563772 JTY_2837 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645884.1 3078529 R 561275 CDS YP_002645885.1 224991196 7563773 complement(3079651..3080298) 1 NC_012207.1 Differs from Rv2825c by 5aa, E2K, C162S, L189V, Q192T, E195A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3080298 7563773 JTY_2838 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645885.1 3079651 R 561275 CDS YP_002645886.1 224991197 7563774 complement(3080468..3081352) 1 NC_012207.1 hypothetical protein 3081352 7563774 JTY_2839 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645886.1 3080468 R 561275 CDS YP_002645887.1 224991198 7563775 complement(3081355..3082242) 1 NC_012207.1 hypothetical protein 3082242 7563775 JTY_2840 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645887.1 3081355 R 561275 CDS YP_002645888.1 224991199 7563776 complement(3082547..3083092) 1 NC_012207.1 Differs from Mb2852c by 1aa E58A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3083092 7563776 JTY_2841 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645888.1 3082547 R 561275 CDS YP_002645889.1 224991200 7563777 complement(3083089..3083358) 1 NC_012207.1 hypothetical protein 3083358 7563777 JTY_2842 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645889.1 3083089 R 561275 CDS YP_002645890.1 224991201 7563778 complement(3083379..3083771) 1 NC_012207.1 hypothetical protein 3083771 7563778 JTY_2843 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645890.1 3083379 R 561275 CDS YP_002645891.1 224991202 7563779 complement(3083768..3083983) 1 NC_012207.1 Differs from Rv2830c by 1aa, V56A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3083983 7563779 JTY_2844 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645891.1 3083768 R 561275 CDS YP_002645892.1 224991203 7563780 3084030..3084779 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 3084779 echA16 7563780 echA16 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002645892.1 3084030 D 561275 CDS YP_002645893.1 224991204 7561527 complement(3084858..3085940) 1 NC_012207.1 Differs from Rv2832c and Mb2856c by 1aa, L235F in BCG Pasteur and BCG Tokyo; sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter 3085940 ugpC 7561527 ugpC Mycobacterium bovis BCG str. Tokyo 172 sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter YP_002645893.1 3084858 R 561275 CDS YP_002645894.1 224991205 7561654 complement(3086611..3087243) 1 NC_012207.1 In mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base mutation (T->A) at corresponding position 3093840, in Mycobacterium tuberculosis H37Rv strain, leads to a stop codon and break ugpB in two parts. Differs from Rv2833c by 2aa, I111S, L174P in BCG Pasteur and BCG Tokyo; sn-glycerol-3-phosphate-transport integral membrane protein ABC transporter 3087243 ugpBa 7561654 ugpBa Mycobacterium bovis BCG str. Tokyo 172 sn-glycerol-3-phosphate-transport integral membrane protein ABC transporter YP_002645894.1 3086611 R 561275 CDS YP_002645895.1 224991206 7561653 complement(3087246..3088073) 1 NC_012207.1 sn-glycerol-3-phosphate transport integral membrane protein ABC transporter 3088073 ugpE 7561653 ugpE Mycobacterium bovis BCG str. Tokyo 172 sn-glycerol-3-phosphate transport integral membrane protein ABC transporter YP_002645895.1 3087246 R 561275 CDS YP_002645896.1 224991207 7561656 complement(3088070..3088981) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo and Mycobacterium tuberculosis strain H37Rv, ugpA exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) splits ugpA into 2 parts, ugpAaand ugpAb; sn-glycerol-3-phosphate transport integral membrane protein ABC transporter 3088981 ugpA 7561656 ugpA Mycobacterium bovis BCG str. Tokyo 172 sn-glycerol-3-phosphate transport integral membrane protein ABC transporter YP_002645896.1 3088070 R 561275 CDS YP_002645897.1 224991208 7561652 complement(3089068..3090387) 1 NC_012207.1 Differs from Rv2836c by 2aa, H157Q, L350P, and from Mb2861c by 1aa, H157Q in BCG Pasteur and BCG Tokyo; DNA-damage-inducible protein F 3090387 dinF 7561652 dinF Mycobacterium bovis BCG str. Tokyo 172 DNA-damage-inducible protein F YP_002645897.1 3089068 R 561275 CDS YP_002645898.1 224991209 7561493 complement(3090394..3091404) 1 NC_012207.1 hypothetical protein 3091404 7561493 JTY_2852 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645898.1 3090394 R 561275 CDS YP_002645899.1 224991210 7563781 complement(3091379..3091930) 1 NC_012207.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 3091930 rbfA 7563781 rbfA Mycobacterium bovis BCG str. Tokyo 172 ribosome-binding factor A YP_002645899.1 3091379 R 561275 CDS YP_002645900.1 224991211 7561550 complement(3091930..3094632) 1 NC_012207.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 3094632 infB 7561550 infB Mycobacterium bovis BCG str. Tokyo 172 translation initiation factor IF-2 YP_002645900.1 3091930 R 561275 CDS YP_002645901.1 224991212 7562786 complement(3094718..3095017) 1 NC_012207.1 hypothetical protein 3095017 7562786 JTY_2855 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645901.1 3094718 R 561275 CDS YP_002645902.1 224991213 7563782 complement(3095144..3096187) 1 NC_012207.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 3096187 nusA 7563782 nusA Mycobacterium bovis BCG str. Tokyo 172 transcription elongation factor NusA YP_002645902.1 3095144 R 561275 CDS YP_002645903.1 224991214 7562488 complement(3096184..3096735) 1 NC_012207.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 3096735 7562488 JTY_2857 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645903.1 3096184 R 561275 CDS YP_002645904.1 224991215 7563783 3096930..3097475 1 NC_012207.1 transmembrane alanine rich protein 3097475 7563783 JTY_2858 Mycobacterium bovis BCG str. Tokyo 172 transmembrane alanine rich protein YP_002645904.1 3096930 D 561275 CDS YP_002645905.1 224991216 7563784 3097472..3097960 1 NC_012207.1 hypothetical alanine rich protein 3097960 7563784 JTY_2859 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine rich protein YP_002645905.1 3097472 D 561275 CDS YP_002645906.1 224991217 7563785 complement(3097961..3099709) 1 NC_012207.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 3099709 proS 7563785 proS Mycobacterium bovis BCG str. Tokyo 172 prolyl-tRNA synthetase YP_002645906.1 3097961 R 561275 CDS YP_002645907.1 224991218 7560827 complement(3099798..3101390) 1 NC_012207.1 Differs from Rv2846c by 1aa, R15T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; integral membrane efflux protein 3101390 efpA 7560827 efpA Mycobacterium bovis BCG str. Tokyo 172 integral membrane efflux protein YP_002645907.1 3099798 R 561275 CDS YP_002645908.1 224991219 7562856 complement(3101413..3102630) 1 NC_012207.1 uroporphyrin-III C-methyltransferase, precorrin-2 oxidase, ferrochelatase; siroheme synthase 3102630 cysG 7562856 cysG Mycobacterium bovis BCG str. Tokyo 172 siroheme synthase YP_002645908.1 3101413 R 561275 CDS YP_002645909.1 224991220 7563176 complement(3102961..3104334) 1 NC_012207.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid; cobyrinic acid a,c-diamide synthase 3104334 cobB 7563176 cobB Mycobacterium bovis BCG str. Tokyo 172 cobyrinic acid a,c-diamide synthase YP_002645909.1 3102961 R 561275 CDS YP_002645910.1 224991221 7563103 complement(3104334..3104957) 1 NC_012207.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 3104957 cobO 7563103 cobO Mycobacterium bovis BCG str. Tokyo 172 cob(I)yrinic acid a,c-diamide adenosyltransferase YP_002645910.1 3104334 R 561275 CDS YP_002645911.1 224991222 7563114 complement(3104978..3106867) 1 NC_012207.1 Differs from Rv2850c by 2aa, Q273R, S446G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; magnesium chelatase 3106867 7563114 JTY_2865 Mycobacterium bovis BCG str. Tokyo 172 magnesium chelatase YP_002645911.1 3104978 R 561275 CDS YP_002645912.1 224991223 7563786 complement(3106864..3107334) 1 NC_012207.1 hypothetical protein 3107334 7563786 JTY_2866 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645912.1 3106864 R 561275 CDS YP_002645913.1 224991224 7563787 complement(3107393..3108874) 1 NC_012207.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 3108874 mqo 7563787 mqo Mycobacterium bovis BCG str. Tokyo 172 malate:quinone oxidoreductase YP_002645913.1 3107393 R 561275 CDS YP_002645914.1 224991225 7563557 3109081..3110874 1 NC_012207.1 Differs from Rv2853 by 3aa, N227K, G228R, D232G, and 18aa deletion, and from Mb2878 by 1aa, D184G, and same 18aa deletion in BCG Pasteur and BCG Tokyo; PE-PGRS family protein 3110874 PE_PGRS48 7563557 PE_PGRS48 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002645914.1 3109081 D 561275 CDS YP_002645915.1 224991226 7562374 3110911..3111951 1 NC_012207.1 hypothetical protein 3111951 7562374 JTY_2869 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645915.1 3110911 D 561275 CDS YP_002645916.1 224991227 7563788 3111964..3113343 1 NC_012207.1 catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide; mycothione reductase 3113343 mtr 7563788 mtr Mycobacterium bovis BCG str. Tokyo 172 mycothione reductase YP_002645916.1 3111964 D 561275 CDS YP_002645917.1 224991228 7563568 3113443..3114561 1 NC_012207.1 nickel-transport integral membrane protein 3114561 nicT 7563568 nicT Mycobacterium bovis BCG str. Tokyo 172 nickel-transport integral membrane protein YP_002645917.1 3113443 D 561275 CDS YP_002645918.1 224991229 7562460 3114627..3114959 1 NC_012207.1 truncated hydrogenase nickle incorporation protein 3114959 7562460 JTY_2872 Mycobacterium bovis BCG str. Tokyo 172 truncated hydrogenase nickle incorporation protein YP_002645918.1 3114627 D 561275 CDS YP_002645919.1 224991230 7563789 3114971..3115186 1 NC_012207.1 truncated hydrogenase nickle incorporation protein 3115186 7563789 JTY_2873 Mycobacterium bovis BCG str. Tokyo 172 truncated hydrogenase nickle incorporation protein YP_002645919.1 3114971 D 561275 CDS YP_002645920.1 224991231 7563790 complement(3115342..3116118) 1 NC_012207.1 short chain dehydrogenase 3116118 7563790 JTY_2874 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002645920.1 3115342 R 561275 CDS YP_002645921.1 224991232 7563791 complement(3116115..3117482) 1 NC_012207.1 aldehyde dehydrogenase 3117482 aldC 7563791 aldC Mycobacterium bovis BCG str. Tokyo 172 aldehyde dehydrogenase YP_002645921.1 3116115 R 561275 CDS YP_002645922.1 224991233 7563960 complement(3117479..3118405) 1 NC_012207.1 amidotransferase 3118405 7563960 JTY_2876 Mycobacterium bovis BCG str. Tokyo 172 amidotransferase YP_002645922.1 3117479 R 561275 CDS YP_002645923.1 224991234 7563792 complement(3118386..3119759) 1 NC_012207.1 glutamine synthetase 3119759 glnA4 7563792 glnA4 Mycobacterium bovis BCG str. Tokyo 172 glutamine synthetase YP_002645923.1 3118386 R 561275 CDS YP_002645924.1 224991235 7561929 complement(3119919..3120776) 1 NC_012207.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential; methionine aminopeptidase 3120776 mapB 7561929 mapB Mycobacterium bovis BCG str. Tokyo 172 methionine aminopeptidase YP_002645924.1 3119919 R 561275 CDS YP_002645925.1 224991236 7564419 complement(3120818..3121402) 1 NC_012207.1 Differs from Rv2862c by 2aa, P18R, R50C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3121402 7564419 JTY_2879 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645925.1 3120818 R 561275 CDS YP_002645926.1 224991237 7563793 3121751..3122131 1 NC_012207.1 hypothetical protein 3122131 7563793 JTY_2880 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645926.1 3121751 D 561275 CDS YP_002645927.1 224991238 7563794 complement(3122213..3124024) 1 NC_012207.1 penicillin-binding lipoprotein 3124024 7563794 JTY_2881 Mycobacterium bovis BCG str. Tokyo 172 penicillin-binding lipoprotein YP_002645927.1 3122213 R 561275 CDS YP_002645928.1 224991239 7563795 3124296..3124577 1 NC_012207.1 hypothetical protein 3124577 7563795 JTY_2882 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645928.1 3124296 D 561275 CDS YP_002645929.1 224991240 7563796 3124581..3124844 1 NC_012207.1 hypothetical protein 3124844 7563796 JTY_2883 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645929.1 3124581 D 561275 CDS YP_002645930.1 224991241 7563797 complement(3125217..3126071) 1 NC_012207.1 hypothetical protein 3126071 7563797 JTY_2884 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645930.1 3125217 R 561275 CDS YP_002645931.1 224991242 7563798 complement(3126127..3127290) 1 NC_012207.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 3127290 ispG 7563798 ispG Mycobacterium bovis BCG str. Tokyo 172 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_002645931.1 3126127 R 561275 CDS YP_002645932.1 224991243 7561908 complement(3127307..3128521) 1 NC_012207.1 Differs from Mb2894c by 1aa, T330A, and from Rv2869c by 2aa, F259V, T330A in BCG Pasteur and BCG Tokyo; transmembrane protein 3128521 7561908 JTY_2886 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002645932.1 3127307 R 561275 CDS YP_002645933.1 224991244 7563799 complement(3128529..3129770) 1 NC_012207.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 3129770 dxr 7563799 dxr Mycobacterium bovis BCG str. Tokyo 172 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_002645933.1 3128529 R 561275 CDS YP_002645934.1 224991245 7561519 3129897..3130154 1 NC_012207.1 hypothetical protein 3130154 7561519 JTY_2888 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645934.1 3129897 D 561275 CDS YP_002645935.1 224991246 7563800 3130141..3130584 1 NC_012207.1 Differs from Rv2872 and Mb2897 by 1aa, T72A in BCG Pasteur and BCG Tokyo; hypothetical protein 3130584 7563800 JTY_2889 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645935.1 3130141 D 561275 CDS YP_002645936.1 224991247 7563801 3130664..3131326 1 NC_012207.1 cell surface lipoprotein 3131326 mpb83 7563801 mpb83 Mycobacterium bovis BCG str. Tokyo 172 cell surface lipoprotein YP_002645936.1 3130664 D 561275 CDS YP_002645937.1 224991248 7563552 3131606..3133693 1 NC_012207.1 Differs from Rv2874 by 1aa, D672Y in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane C-type cytochrome biogenesis protein 3133693 dipZ 7563552 dipZ Mycobacterium bovis BCG str. Tokyo 172 integral membrane C-type cytochrome biogenesis protein YP_002645937.1 3131606 D 561275 CDS YP_002645938.1 224991249 7561497 3133789..3134370 1 NC_012207.1 major immunogenic protein precursor 3134370 mpb70 7561497 mpb70 Mycobacterium bovis BCG str. Tokyo 172 major immunogenic protein precursor YP_002645938.1 3133789 D 561275 CDS YP_002645939.1 224991250 7563551 3134422..3134736 1 NC_012207.1 hypothetical protein 3134736 7563551 JTY_2893 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645939.1 3134422 D 561275 CDS YP_002645940.1 224991251 7563802 complement(3134767..3135630) 1 NC_012207.1 Differs from Rv2877c by 1aa, H35Y in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein 3135630 7563802 JTY_2894 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002645940.1 3134767 R 561275 CDS YP_002645941.1 224991252 7563803 complement(3135635..3136156) 1 NC_012207.1 soluble antigen 3136156 mpb53 7563803 mpb53 Mycobacterium bovis BCG str. Tokyo 172 soluble antigen YP_002645941.1 3135635 R 561275 CDS YP_002645942.1 224991253 7563550 complement(3136342..3137436) 1 NC_012207.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 3137436 7563550 JTY_2896 Mycobacterium bovis BCG str. Tokyo 172 ribosomal RNA large subunit methyltransferase N YP_002645942.1 3136342 R 561275 CDS YP_002645943.1 224991254 7563804 complement(3137459..3138379) 1 NC_012207.1 integral membrane phosphatidate cytidylyltransferase 3138379 cdsA 7563804 cdsA Mycobacterium bovis BCG str. Tokyo 172 integral membrane phosphatidate cytidylyltransferase YP_002645943.1 3137459 R 561275 CDS YP_002645944.1 224991255 7562091 complement(3138402..3138959) 1 NC_012207.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 3138959 frr 7562091 frr Mycobacterium bovis BCG str. Tokyo 172 ribosome recycling factor YP_002645944.1 3138402 R 561275 CDS YP_002645945.1 224991256 7561875 complement(3139131..3139916) 1 NC_012207.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 3139916 pyrH 7561875 pyrH Mycobacterium bovis BCG str. Tokyo 172 uridylate kinase YP_002645945.1 3139131 R 561275 CDS YP_002645946.1 224991257 7561543 3140151..3140909 1 NC_012207.1 transcriptional regulatory protein 3140909 7561543 JTY_2900 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645946.1 3140151 D 561275 CDS YP_002645947.1 224991258 7563805 complement(3140988..3142307) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-c) leads to a truncation resulting in a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (439 aa versus 460 aa); transposase 3142307 7563805 JTY_2901 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002645947.1 3140988 R 561275 CDS YP_002645948.1 224991259 7563806 complement(3142304..3143191) 1 NC_012207.1 resolvase 3143191 7563806 JTY_2902 Mycobacterium bovis BCG str. Tokyo 172 resolvase YP_002645948.1 3142304 R 561275 CDS YP_002645949.1 224991260 7563807 3143190..3143609 1 NC_012207.1 transcriptional regulatory protein 3143609 7563807 JTY_2903 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645949.1 3143190 D 561275 CDS YP_002645950.1 224991261 7563808 complement(3143623..3145044) 1 NC_012207.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 3145044 amiC 7563808 amiC Mycobacterium bovis BCG str. Tokyo 172 amidase YP_002645950.1 3143623 R 561275 CDS YP_002645951.1 224991262 7563973 complement(3145051..3145866) 1 NC_012207.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 3145866 tsf 7563973 tsf Mycobacterium bovis BCG str. Tokyo 172 elongation factor Ts YP_002645951.1 3145051 R 561275 CDS YP_002645952.1 224991263 7561642 complement(3145878..3146741) 1 NC_012207.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 3146741 rpsB 7561642 rpsB Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S2 YP_002645952.1 3145878 R 561275 CDS YP_002645953.1 224991264 7560729 3147025..3147774 1 NC_012207.1 hypothetical protein 3147774 7560729 JTY_2907 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645953.1 3147025 D 561275 CDS YP_002645954.1 224991265 7563809 complement(3147553..3148779) 1 NC_012207.1 PPE family protein 3148779 PPE45 7563809 PPE45 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002645954.1 3147553 R 561275 CDS YP_002645955.1 224991266 7562183 3149179..3150156 1 NC_012207.1 oxidoreductase 3150156 7562183 JTY_2909 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002645955.1 3149179 D 561275 CDS YP_002645956.1 224991267 7563810 complement(3150153..3151049) 1 NC_012207.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 3151049 xerC 7563810 xerC Mycobacterium bovis BCG str. Tokyo 172 site-specific tyrosine recombinase XerC YP_002645956.1 3150153 R 561275 CDS YP_002645957.1 224991268 7561696 complement(3151140..3151991) 1 NC_012207.1 mycobactin utilization protein 3151991 viuB 7561696 viuB Mycobacterium bovis BCG str. Tokyo 172 mycobactin utilization protein YP_002645957.1 3151140 R 561275 CDS YP_002645958.1 224991269 7561682 complement(3152024..3153193) 1 NC_012207.1 Differs from Rv2896c by 2aa, G57E, A153S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 3153193 7561682 JTY_2912 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645958.1 3152024 R 561275 CDS YP_002645959.1 224991270 7563811 complement(3153190..3154701) 1 NC_012207.1 hypothetical protein 3154701 7563811 JTY_2913 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645959.1 3153190 R 561275 CDS YP_002645960.1 224991271 7563812 complement(3154701..3155087) 1 NC_012207.1 hypothetical protein 3155087 7563812 JTY_2914 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645960.1 3154701 R 561275 CDS YP_002645961.1 224991272 7563813 complement(3155335..3156165) 1 NC_012207.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 3156165 fdhD 7563813 fdhD Mycobacterium bovis BCG str. Tokyo 172 formate dehydrogenase accessory protein YP_002645961.1 3155335 R 561275 CDS YP_002645962.1 224991273 7563404 complement(3156165..3158504) 1 NC_012207.1 formate dehydrogenase H 3158504 fdhF 7563404 fdhF Mycobacterium bovis BCG str. Tokyo 172 formate dehydrogenase H YP_002645962.1 3156165 R 561275 CDS YP_002645963.1 224991274 7563405 complement(3158562..3158867) 1 NC_012207.1 hypothetical protein 3158867 7563405 JTY_2917 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645963.1 3158562 R 561275 CDS YP_002645964.1 224991275 7563814 complement(3158921..3159715) 1 NC_012207.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 3159715 rnhB 7563814 rnhB Mycobacterium bovis BCG str. Tokyo 172 ribonuclease HII YP_002645964.1 3158921 R 561275 CDS YP_002645965.1 224991276 7561588 complement(3159729..3160613) 1 NC_012207.1 Differs from Rv2903c by 1aa, N2564D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; signal peptidase I 3160613 lepB 7561588 lepB Mycobacterium bovis BCG str. Tokyo 172 signal peptidase I YP_002645965.1 3159729 R 561275 CDS YP_002645966.1 224991277 7562812 complement(3160671..3161012) 1 NC_012207.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 3161012 rplS 7562812 rplS Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L19 YP_002645966.1 3160671 R 561275 CDS YP_002645967.1 224991278 7561619 3161387..3162331 1 NC_012207.1 alanine rich lipoprotein 3162331 lppW 7561619 lppW Mycobacterium bovis BCG str. Tokyo 172 alanine rich lipoprotein YP_002645967.1 3161387 D 561275 CDS YP_002645968.1 224991279 7560489 complement(3162424..3163116) 1 NC_012207.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 3163116 trmD 7560489 trmD Mycobacterium bovis BCG str. Tokyo 172 tRNA (guanine-N(1)-)-methyltransferase YP_002645968.1 3162424 R 561275 CDS YP_002645969.1 224991280 7561626 complement(3163120..3163650) 1 NC_012207.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 3163650 rimM 7561626 rimM Mycobacterium bovis BCG str. Tokyo 172 16S rRNA-processing protein RimM YP_002645969.1 3163120 R 561275 CDS YP_002645970.1 224991281 7561580 complement(3163664..3163906) 1 NC_012207.1 hypothetical protein 3163906 7561580 JTY_2924 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645970.1 3163664 R 561275 CDS YP_002645971.1 224991282 7563815 complement(3163914..3164402) 1 NC_012207.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 3164402 rpsP 7563815 rpsP Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S16 YP_002645971.1 3163914 R 561275 CDS YP_002645972.1 224991283 7560744 complement(3164586..3165029) 1 NC_012207.1 hypothetical protein 3165029 7560744 JTY_2926 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645972.1 3164586 R 561275 CDS YP_002645973.1 224991284 7563816 3165098..3165973 1 NC_012207.1 D-alanyl-D-alanine carboxypeptidase 3165973 dacB2 7563816 dacB2 Mycobacterium bovis BCG str. Tokyo 172 D-alanyl-D-alanine carboxypeptidase YP_002645973.1 3165098 D 561275 CDS YP_002645974.1 224991285 7561465 complement(3166033..3166620) 1 NC_012207.1 probably TetR-family; transcriptional regulatory protein 3166620 7561465 JTY_2928 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002645974.1 3166033 R 561275 CDS YP_002645975.1 224991286 7563817 complement(3166622..3168457) 1 NC_012207.1 D-amino acid aminohydrolase 3168457 7563817 JTY_2929 Mycobacterium bovis BCG str. Tokyo 172 D-amino acid aminohydrolase YP_002645975.1 3166622 R 561275 CDS YP_002645976.1 224991287 7563818 complement(3168526..3170283) 1 NC_012207.1 transmembrane serine/threonine-protein kinase I 3170283 pknI 7563818 pknI Mycobacterium bovis BCG str. Tokyo 172 transmembrane serine/threonine-protein kinase I YP_002645976.1 3168526 R 561275 CDS YP_002645977.1 224991288 7562436 complement(3170327..3171439) 1 NC_012207.1 hypothetical protein 3171439 7562436 JTY_2931 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645977.1 3170327 R 561275 CDS YP_002645978.1 224991289 7563819 complement(3171467..3173044) 1 NC_012207.1 signal recognition particle protein 3173044 ffh 7563819 ffh Mycobacterium bovis BCG str. Tokyo 172 signal recognition particle protein YP_002645978.1 3171467 R 561275 CDS YP_002645979.1 224991290 7563411 3173122..3175002 1 NC_012207.1 Differs from Rv2917 by 1aa, L594R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical alanine and arginine rich protein 3175002 7563411 JTY_2933 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine and arginine rich protein YP_002645979.1 3173122 D 561275 CDS YP_002645980.1 224991291 7563820 complement(3175013..3177439) 1 NC_012207.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; also involved in adenylylating and deadelnylyating GlnK; PII uridylyl-transferase 3177439 glnD 7563820 glnD Mycobacterium bovis BCG str. Tokyo 172 PII uridylyl-transferase YP_002645980.1 3175013 R 561275 CDS YP_002645981.1 224991292 7561931 complement(3177497..3177835) 1 NC_012207.1 nitrogen regulatory protein P-II 3177835 glnB 7561931 glnB Mycobacterium bovis BCG str. Tokyo 172 nitrogen regulatory protein P-II YP_002645981.1 3177497 R 561275 CDS YP_002645982.1 224991293 7561930 complement(3177832..3179265) 1 NC_012207.1 ammonium-transport integral membrane protein 3179265 amt 7561930 amt Mycobacterium bovis BCG str. Tokyo 172 ammonium-transport integral membrane protein YP_002645982.1 3177832 R 561275 CDS YP_002645983.1 224991294 7563975 complement(3179742..3181010) 1 NC_012207.1 cell division protein 3181010 ftsY 7563975 ftsY Mycobacterium bovis BCG str. Tokyo 172 cell division protein YP_002645983.1 3179742 R 561275 CDS YP_002645984.1 224991295 7561882 complement(3181060..3184677) 1 NC_012207.1 Differs from Rv2922c by 2aa, R364L, G698R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; chromosome partition protein 3184677 smc 7561882 smc Mycobacterium bovis BCG str. Tokyo 172 chromosome partition protein YP_002645984.1 3181060 R 561275 CDS YP_002645985.1 224991296 7561800 complement(3184689..3184970) 1 NC_012207.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 3184970 acyP 7561800 acyP Mycobacterium bovis BCG str. Tokyo 172 acylphosphatase YP_002645985.1 3184689 R 561275 CDS YP_002645986.1 224991297 7563936 complement(3184957..3185370) 1 NC_012207.1 hypothetical protein 3185370 7563936 JTY_2940 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645986.1 3184957 R 561275 CDS YP_002645987.1 224991298 7563821 complement(3185472..3186341) 1 NC_012207.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 3186341 fpg 7563821 fpg Mycobacterium bovis BCG str. Tokyo 172 formamidopyrimidine-DNA glycosylase YP_002645987.1 3185472 R 561275 CDS YP_002645988.1 224991299 7563426 complement(3186645..3187367) 1 NC_012207.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 3187367 rnc 7563426 rnc Mycobacterium bovis BCG str. Tokyo 172 ribonuclease III YP_002645988.1 3186645 R 561275 CDS YP_002645989.1 224991300 7561586 complement(3187364..3187987) 1 NC_012207.1 hypothetical protein 3187987 7561586 JTY_2943 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645989.1 3187364 R 561275 CDS YP_002645990.1 224991301 7563822 complement(3188038..3188775) 1 NC_012207.1 hypothetical protein 3188775 7563822 JTY_2944 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645990.1 3188038 R 561275 CDS YP_002645991.1 224991302 7563823 3189014..3189799 1 NC_012207.1 thioesterase 3189799 tesA 7563823 tesA Mycobacterium bovis BCG str. Tokyo 172 thioesterase YP_002645991.1 3189014 D 561275 CDS YP_002645992.1 224991303 7561839 3189786..3190097 1 NC_012207.1 hypothetical protein 3190097 7561839 JTY_2946 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002645992.1 3189786 D 561275 CDS YP_002645993.1 224991304 7563824 3190513..3192264 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3192264 fadD26 7563824 fadD26 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002645993.1 3190513 D 561275 CDS YP_002645994.1 224991305 7562932 3192261..3197891 1 NC_012207.1 Differs from Rv2931 at several positions in BCG Pasteur and BCG Tokyo; phenolpthiocerol synthesis type-I polyketide synthase 3197891 ppsA 7562932 ppsA Mycobacterium bovis BCG str. Tokyo 172 phenolpthiocerol synthesis type-I polyketide synthase YP_002645994.1 3192261 D 561275 CDS YP_002645995.1 224991306 7560812 3197888..3202504 1 NC_012207.1 Differs from Mb2957 and Rv2932 at several positions in BCG Pasteur and BCG Tokyo; phenolpthiocerol synthesis type-I polyketide synthase 3202504 ppsB 7560812 ppsB Mycobacterium bovis BCG str. Tokyo 172 phenolpthiocerol synthesis type-I polyketide synthase YP_002645995.1 3197888 D 561275 CDS YP_002645996.1 224991307 7560813 3202501..3209067 1 NC_012207.1 phenolpthiocerol synthesis type-I polyketide synthase 3209067 ppsC 7560813 ppsC Mycobacterium bovis BCG str. Tokyo 172 phenolpthiocerol synthesis type-I polyketide synthase YP_002645996.1 3202501 D 561275 CDS YP_002645997.1 224991308 7560814 3209064..3214547 1 NC_012207.1 Differs from Rv2934 at several positions in BCG Pasteur and BCG Tokyo; phenolpthiocerol synthesis type-I polyketide synthase 3214547 ppsD 7560814 ppsD Mycobacterium bovis BCG str. Tokyo 172 phenolpthiocerol synthesis type-I polyketide synthase YP_002645997.1 3209064 D 561275 CDS YP_002645998.1 224991309 7560815 3214553..3219019 1 NC_012207.1 Differs from Rv2935 at several positions in BCG Pasteur and BCG Tokyo; phenolpthiocerol synthesis type-I polyketide synthase 3219019 ppsE 7560815 ppsE Mycobacterium bovis BCG str. Tokyo 172 phenolpthiocerol synthesis type-I polyketide synthase YP_002645998.1 3214553 D 561275 CDS YP_002645999.1 224991310 7560816 3219030..3220025 1 NC_012207.1 Differs from Rv2936 by 1aa, D309H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; daunorubicin-DIM-transport ATP-binding protein ABC transporter 3220025 drrA 7560816 drrA Mycobacterium bovis BCG str. Tokyo 172 daunorubicin-DIM-transport ATP-binding protein ABC transporter YP_002645999.1 3219030 D 561275 CDS YP_002646000.1 224991311 7561514 3220022..3220891 1 NC_012207.1 daunorubicin-DIM-transport integral membrane protein ABC transporter 3220891 drrB 7561514 drrB Mycobacterium bovis BCG str. Tokyo 172 daunorubicin-DIM-transport integral membrane protein ABC transporter YP_002646000.1 3220022 D 561275 CDS YP_002646001.1 224991312 7561515 3220888..3221718 1 NC_012207.1 daunorubicin-DIM-transport integral membrane protein ABC transporter 3221718 drrC 7561515 drrC Mycobacterium bovis BCG str. Tokyo 172 daunorubicin-DIM-transport integral membrane protein ABC transporter YP_002646001.1 3220888 D 561275 CDS YP_002646002.1 224991313 7561516 3221765..3223033 1 NC_012207.1 required for PDIM synthesis; phthiocerol and phthiodiolone dimycocerosate esters are scaffolds used for virulence-enhancing lipids; proposed to catalyze diesterification of phthiocerol and phthiodolone with mycocerosate; functions in polyketide synthesis; acyltransferase 3223033 papA5 7561516 papA5 Mycobacterium bovis BCG str. Tokyo 172 acyltransferase YP_002646002.1 3221765 D 561275 CDS YP_002646003.1 224991314 7562515 complement(3223196..3229531) 1 NC_012207.1 multifunctional mycocerosic acid synthase membrane-associated 3229531 mas 7562515 mas Mycobacterium bovis BCG str. Tokyo 172 multifunctional mycocerosic acid synthase membrane-associated YP_002646003.1 3223196 R 561275 CDS YP_002646004.1 224991315 7564420 3230151..3231893 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3231893 fadD28 7564420 fadD28 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002646004.1 3230151 D 561275 CDS YP_002646005.1 224991316 7562933 3231886..3234648 1 NC_012207.1 conserved transmembrane transport protein 3234648 mmpL7 7562933 mmpL7 Mycobacterium bovis BCG str. Tokyo 172 conserved transmembrane transport protein YP_002646005.1 3231886 D 561275 CDS YP_002646006.1 224991317 7564492 3235280..3236521 1 NC_012207.1 transposase for insertion sequence element IS1533 3236521 7564492 JTY_2960 Mycobacterium bovis BCG str. Tokyo 172 transposase for insertion sequence element IS1533 YP_002646006.1 3235280 D 561275 CDS YP_002646007.1 224991318 7563825 3236521..3237051 1 NC_012207.1 transposase 3237051 7563825 JTY_2961 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646007.1 3236521 D 561275 CDS YP_002646008.1 224991319 7563826 complement(3237440..3238141) 1 NC_012207.1 lipoprotein 3238141 lppX 7563826 lppX Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002646008.1 3237440 R 561275 CDS YP_002646009.1 224991320 7560490 complement(3238490..3244828) 1 NC_012207.1 In Mycobacterium tuberculosis H37Rv, pks1 and pks15 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-G) results in a single product that is more similar to pks1. Differs from Rv2946c by 2aa, G1779V, V1859A, and from Rv2947c by 2aa, A333V, R374G in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo.; polyketide synthase 3244828 pks1 7560490 pks1 Mycobacterium bovis BCG str. Tokyo 172 polyketide synthase YP_002646009.1 3238490 R 561275 CDS YP_002646010.1 224991321 7562440 complement(3244825..3246942) 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3246942 fadD22 7562440 fadD22 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002646010.1 3244825 R 561275 CDS YP_002646011.1 224991322 7562928 complement(3246959..3247558) 1 NC_012207.1 hypothetical protein 3247558 7562928 JTY_2965 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646011.1 3246959 R 561275 CDS YP_002646012.1 224991323 7563827 complement(3247584..3249443) 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3249443 fadD29 7563827 fadD29 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002646012.1 3247584 R 561275 CDS YP_002646013.1 224991324 7562934 complement(3250091..3251236) 1 NC_012207.1 oxidoreductase 3251236 7562934 JTY_2967 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646013.1 3250091 R 561275 CDS YP_002646014.1 224991325 7563828 3251429..3252241 1 NC_012207.1 methyltransferase 3252241 7563828 JTY_2968 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase YP_002646014.1 3251429 D 561275 CDS YP_002646015.1 224991326 7563829 3252267..3253523 1 NC_012207.1 hypothetical protein 3253523 7563829 JTY_2969 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646015.1 3252267 D 561275 CDS YP_002646016.1 224991327 7563830 complement(3253654..3254379) 1 NC_012207.1 Differs from Rv2954c and Mb2978c by 1aa, Q194R in BCG Pasteur and BCG Tokyo; hypothetical protein 3254379 7563830 JTY_2970 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646016.1 3253654 R 561275 CDS YP_002646017.1 224991328 7563831 complement(3254568..3255533) 1 NC_012207.1 Differs from Rv2955c by 1aa, H27R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3255533 7563831 JTY_2971 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646017.1 3254568 R 561275 CDS YP_002646018.1 224991329 7563832 3255656..3256387 1 NC_012207.1 Differs from Rv2956 by 1aa, T237I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3256387 7563832 JTY_2972 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646018.1 3255656 D 561275 CDS YP_002646019.1 224991330 7563833 3256458..3257285 1 NC_012207.1 glycosyl transferase 3257285 7563833 JTY_2973 Mycobacterium bovis BCG str. Tokyo 172 glycosyl transferase YP_002646019.1 3256458 D 561275 CDS YP_002646020.1 224991331 7563834 complement(3257889..3258989) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; glycosyl transferase 3258989 7563834 JTY_2974 Mycobacterium bovis BCG str. Tokyo 172 glycosyl transferase YP_002646020.1 3257889 R 561275 CDS YP_002646021.1 224991332 7563835 complement(3259090..3259827) 1 NC_012207.1 methyltransferase 3259827 7563835 JTY_2975 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase YP_002646021.1 3259090 R 561275 CDS YP_002646022.1 224991333 7563836 complement(3259942..3260190) 1 NC_012207.1 hypothetical protein 3260190 7563836 JTY_2976 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646022.1 3259942 R 561275 CDS YP_002646023.1 224991334 7563837 3260272..3260661 1 NC_012207.1 transposase 3260661 7563837 JTY_2977 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646023.1 3260272 D 561275 CDS YP_002646024.1 224991335 7563838 complement(3260762..3262111) 1 NC_012207.1 glycosyl transferase 3262111 7563838 JTY_2978 Mycobacterium bovis BCG str. Tokyo 172 glycosyl transferase YP_002646024.1 3260762 R 561275 CDS YP_002646025.1 224991336 7563839 3262225..3263445 1 NC_012207.1 integral membrane protein 3263445 7563839 JTY_2979 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002646025.1 3262225 D 561275 CDS YP_002646026.1 224991337 7562692 3263518..3264450 1 NC_012207.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 3264450 purU 7562692 purU Mycobacterium bovis BCG str. Tokyo 172 formyltetrahydrofolate deformylase YP_002646026.1 3263518 D 561275 CDS YP_002646027.1 224991338 7560867 complement(3265319..3265804) 1 NC_012207.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 3265804 coaD 7560867 coaD Mycobacterium bovis BCG str. Tokyo 172 phosphopantetheine adenylyltransferase YP_002646027.1 3265319 R 561275 CDS YP_002646028.1 224991339 7561789 complement(3265890..3266456) 1 NC_012207.1 methyltransferase 3266456 7561789 JTY_2982 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase YP_002646028.1 3265890 R 561275 CDS YP_002646029.1 224991340 7562693 complement(3266652..3270035) 1 NC_012207.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate; pyruvate carboxylase 3270035 pca 7562693 pca Mycobacterium bovis BCG str. Tokyo 172 pyruvate carboxylase YP_002646029.1 3266652 R 561275 CDS YP_002646030.1 224991341 7562520 complement(3270060..3270692) 1 NC_012207.1 integral membrane protein 3270692 7562520 JTY_2984 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002646030.1 3270060 R 561275 CDS YP_002646031.1 224991342 7562694 complement(3270698..3271465) 1 NC_012207.1 membrane or hypothetical protein 3271465 7562694 JTY_2985 Mycobacterium bovis BCG str. Tokyo 172 membrane or hypothetical protein YP_002646031.1 3270698 R 561275 CDS YP_002646032.1 224991343 7562695 complement(3271562..3272692) 1 NC_012207.1 lipase/esterase 3272692 lipN 7562695 lipN Mycobacterium bovis BCG str. Tokyo 172 lipase/esterase YP_002646032.1 3271562 R 561275 CDS YP_002646033.1 224991344 7562841 3272923..3273093 1 NC_012207.1 hypothetical protein 3273093 7562841 JTY_2987 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646033.1 3272923 D 561275 CDS YP_002646034.1 224991345 7562696 3273090..3273938 1 NC_012207.1 Differs from Rv2971 by 1aa, H152N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 3273938 7562696 JTY_2988 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646034.1 3273090 D 561275 CDS YP_002646035.1 224991346 7562697 complement(3274012..3274725) 1 NC_012207.1 membrane or exported protein 3274725 7562697 JTY_2989 Mycobacterium bovis BCG str. Tokyo 172 membrane or exported protein YP_002646035.1 3274012 R 561275 CDS YP_002646036.1 224991347 7562698 complement(3274722..3276935) 1 NC_012207.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 3276935 recG 7562698 recG Mycobacterium bovis BCG str. Tokyo 172 ATP-dependent DNA helicase RecG YP_002646036.1 3274722 R 561275 CDS YP_002646037.1 224991348 7561559 complement(3276938..3278599) 1 NC_012207.1 In Mycobacterium tuberculosis H37Rv, Rv2975c and Rv2974c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 2 bp deletion (CG-*) results in a single product that is more similar to Rv2974c; hypothetical alanine rich protein 3278599 7561559 JTY_2991 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine rich protein YP_002646037.1 3276938 R 561275 CDS YP_002646038.1 224991349 7562699 complement(3279058..3279741) 1 NC_012207.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 3279741 ung 7562699 ung Mycobacterium bovis BCG str. Tokyo 172 uracil-DNA glycosylase YP_002646038.1 3279058 R 561275 CDS YP_002646039.1 224991350 7561658 complement(3279774..3280775) 1 NC_012207.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 3280775 thiL 7561658 thiL Mycobacterium bovis BCG str. Tokyo 172 thiamine monophosphate kinase YP_002646039.1 3279774 R 561275 CDS YP_002646040.1 224991351 7561846 complement(3280772..3282151) 1 NC_012207.1 transposase 3282151 7561846 JTY_2994 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646040.1 3280772 R 561275 CDS YP_002646041.1 224991352 7562700 complement(3282151..3282735) 1 NC_012207.1 Differs from Rv2979c by 3aa, R14P, A79T, G151D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; resolvase 3282735 7562700 JTY_2995 Mycobacterium bovis BCG str. Tokyo 172 resolvase YP_002646041.1 3282151 R 561275 CDS YP_002646042.1 224991353 7562701 3282947..3283492 1 NC_012207.1 hypothetical protein 3283492 7562701 JTY_2996 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646042.1 3282947 D 561275 CDS YP_002646043.1 224991354 7562702 complement(3283960..3285081) 1 NC_012207.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 3285081 ddl 7562702 ddl Mycobacterium bovis BCG str. Tokyo 172 D-alanyl-alanine synthetase A YP_002646043.1 3283960 R 561275 CDS YP_002646044.1 224991355 7561472 complement(3285159..3286163) 1 NC_012207.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 3286163 gpsA 7561472 gpsA Mycobacterium bovis BCG str. Tokyo 172 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_002646044.1 3285159 R 561275 CDS YP_002646045.1 224991356 7563277 3286282..3286926 1 NC_012207.1 hypothetical alanine rich protein 3286926 7563277 JTY_2999 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine rich protein YP_002646045.1 3286282 D 561275 CDS YP_002646046.1 224991357 7562703 3287018..3289246 1 NC_012207.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 3289246 ppk 7562703 ppk Mycobacterium bovis BCG str. Tokyo 172 polyphosphate kinase YP_002646046.1 3287018 D 561275 CDS YP_002646047.1 224991358 7560808 3289329..3290282 1 NC_012207.1 hydrolase 3290282 mutT1 7560808 mutT1 Mycobacterium bovis BCG str. Tokyo 172 hydrolase YP_002646047.1 3289329 D 561275 CDS YP_002646048.1 224991359 7563581 complement(3290340..3290957) 1 NC_012207.1 Differs from Rv2986c and Mb3010c by 9aa deletion atposition 137 in BCG Pasteur and BCG Tokyo; DNA-binding protein HU homolog 3290957 hupB 7563581 hupB Mycobacterium bovis BCG str. Tokyo 172 DNA-binding protein HU homolog YP_002646048.1 3290340 R 561275 CDS YP_002646049.1 224991360 7563334 complement(3291170..3291766) 1 NC_012207.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 3291766 leuD 7563334 leuD Mycobacterium bovis BCG str. Tokyo 172 isopropylmalate isomerase small subunit YP_002646049.1 3291170 R 561275 CDS YP_002646050.1 224991361 7562816 complement(3291791..3293212) 1 NC_012207.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 3293212 leuC 7562816 leuC Mycobacterium bovis BCG str. Tokyo 172 isopropylmalate isomerase large subunit YP_002646050.1 3291791 R 561275 CDS YP_002646051.1 224991362 7562815 3293284..3293985 1 NC_012207.1 transcriptional regulatory protein 3293985 7562815 JTY_3005 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646051.1 3293284 D 561275 CDS YP_002646052.1 224991363 7562704 complement(3293996..3294856) 1 NC_012207.1 Differs from Mb3014c by 1aa, A217E in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3294856 7562704 JTY_3006 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646052.1 3293996 R 561275 CDS YP_002646053.1 224991364 7562705 3295119..3295610 1 NC_012207.1 Differs from Rv2991 by 1aa, T93A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3295610 7562705 JTY_3007 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646053.1 3295119 D 561275 CDS YP_002646054.1 224991365 7561936 complement(3295942..3297414) 1 NC_012207.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 3297414 gltX 7561936 gltX Mycobacterium bovis BCG str. Tokyo 172 glutamyl-tRNA synthetase YP_002646054.1 3295942 R 561275 CDS YP_002646055.1 224991366 7561949 complement(3297411..3298130) 1 NC_012207.1 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase 3298130 7561949 JTY_3009 Mycobacterium bovis BCG str. Tokyo 172 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase YP_002646055.1 3297411 R 561275 CDS YP_002646056.1 224991367 7562707 3298406..3299743 1 NC_012207.1 integral membrane protein 3299743 7562707 JTY_3010 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002646056.1 3298406 D 561275 CDS YP_002646057.1 224991368 7562708 complement(3299595..3300605) 1 NC_012207.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 3300605 leuB 7562708 leuB Mycobacterium bovis BCG str. Tokyo 172 3-isopropylmalate dehydrogenase YP_002646057.1 3299595 R 561275 CDS YP_002646058.1 224991369 7562814 complement(3300620..3302206) 1 NC_012207.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 3302206 serA1 7562814 serA1 Mycobacterium bovis BCG str. Tokyo 172 D-3-phosphoglycerate dehydrogenase YP_002646058.1 3300620 R 561275 CDS YP_002646059.1 224991370 7560779 3302236..3303678 1 NC_012207.1 Differs from Rv2997 by 1aa S108C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; alanine rich dehydrogenase 3303678 7560779 JTY_3013 Mycobacterium bovis BCG str. Tokyo 172 alanine rich dehydrogenase YP_002646059.1 3302236 D 561275 CDS YP_002646060.1 224991371 7562709 3303952..3304413 1 NC_012207.1 hypothetical protein 3304413 7562709 JTY_3014 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646060.1 3303952 D 561275 CDS YP_002646061.1 224991372 7562710 complement(3304362..3304565) 1 NC_012207.1 hypothetical protein 3304565 7562710 JTY_3015 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646061.1 3304362 R 561275 CDS YP_002646062.1 224991373 7562711 3304739..3305704 1 NC_012207.1 Differs from Rv2999 by 1aa, L212M in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 3305704 lppY 7562711 lppY Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002646062.1 3304739 D 561275 CDS YP_002646063.1 224991374 7560491 3305749..3306408 1 NC_012207.1 transmembrane protein 3306408 7560491 JTY_3017 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646063.1 3305749 D 561275 CDS YP_002646064.1 224991375 7562712 complement(3306722..3307723) 1 NC_012207.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 3307723 ilvC 7562712 ilvC Mycobacterium bovis BCG str. Tokyo 172 ketol-acid reductoisomerase YP_002646064.1 3306722 R 561275 CDS YP_002646065.1 224991376 7562778 complement(3307761..3308267) 1 NC_012207.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 3308267 ilvH 7562778 ilvH Mycobacterium bovis BCG str. Tokyo 172 acetolactate synthase 3 regulatory subunit YP_002646065.1 3307761 R 561275 CDS YP_002646066.1 224991377 7562782 complement(3308267..3310123) 1 NC_012207.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 1 catalytic subunit 3310123 ilvB1 7562782 ilvB1 Mycobacterium bovis BCG str. Tokyo 172 acetolactate synthase 1 catalytic subunit YP_002646066.1 3308267 R 561275 CDS YP_002646067.1 224991378 7562776 3310485..3310823 1 NC_012207.1 low molecular weight protein antigen 6 3310823 cfp6 7562776 cfp6 Mycobacterium bovis BCG str. Tokyo 172 low molecular weight protein antigen 6 YP_002646067.1 3310485 D 561275 CDS YP_002646068.1 224991379 7562101 complement(3310830..3311669) 1 NC_012207.1 hypothetical protein 3311669 7562101 JTY_3022 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646068.1 3310830 R 561275 CDS YP_002646069.1 224991380 7562713 3311846..3312967 1 NC_012207.1 Differs from Rv3006 by 1aa, D219G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 3312967 lppZ 7562713 lppZ Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002646069.1 3311846 D 561275 CDS YP_002646070.1 224991381 7560492 complement(3312973..3313587) 1 NC_012207.1 oxidoreductase 3313587 7560492 JTY_3024 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646070.1 3312973 R 561275 CDS YP_002646071.1 224991382 7562714 3313781..3314404 1 NC_012207.1 hypothetical protein 3314404 7562714 JTY_3025 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646071.1 3313781 D 561275 CDS YP_002646072.1 224991383 7562715 complement(3314401..3315930) 1 NC_012207.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 3315930 gatB 7562715 gatB Mycobacterium bovis BCG str. Tokyo 172 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_002646072.1 3314401 R 561275 CDS YP_002646073.1 224991384 7561904 complement(3315960..3316991) 1 NC_012207.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 3316991 pfkA 7561904 pfkA Mycobacterium bovis BCG str. Tokyo 172 6-phosphofructokinase YP_002646073.1 3315960 R 561275 CDS YP_002646074.1 224991385 7562395 complement(3317087..3318571) 1 NC_012207.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 3318571 gatA 7562395 gatA Mycobacterium bovis BCG str. Tokyo 172 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_002646074.1 3317087 R 561275 CDS YP_002646075.1 224991386 7561903 complement(3318568..3318867) 1 NC_012207.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 3318867 gatC 7561903 gatC Mycobacterium bovis BCG str. Tokyo 172 aspartyl/glutamyl-tRNA amidotransferase subunit C YP_002646075.1 3318568 R 561275 CDS YP_002646076.1 224991387 7561905 3318952..3319608 1 NC_012207.1 hypothetical protein 3319608 7561905 JTY_3030 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646076.1 3318952 D 561275 CDS YP_002646077.1 224991388 7562716 complement(3319682..3321757) 1 NC_012207.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 3321757 ligA 7562716 ligA Mycobacterium bovis BCG str. Tokyo 172 NAD-dependent DNA ligase LigA YP_002646077.1 3319682 R 561275 CDS YP_002646078.1 224991389 7562826 complement(3321788..3322801) 1 NC_012207.1 hypothetical protein 3322801 7562826 JTY_3032 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646078.1 3321788 R 561275 CDS YP_002646079.1 224991390 7562717 3322895..3323524 1 NC_012207.1 lipoprotein 3323524 lpqA 7562717 lpqA Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002646079.1 3322895 D 561275 CDS YP_002646080.1 224991391 7560493 complement(3323627..3323989) 1 NC_012207.1 EsaT-6 like protein 8 3323989 esxQ 7560493 esxQ Mycobacterium bovis BCG str. Tokyo 172 EsaT-6 like protein 8 YP_002646080.1 3323627 R 561275 CDS YP_002646081.1 224991392 7562887 complement(3324076..3325389) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 56 bp deletion leads to a products lightly different at the N-terminus part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (434 aa versus 437 aa). Differs from Rv3018c by 1aa, A53V, and Mb3043c by 1aa, L328V in BCG Pasteur, and BCG Tokyo; PPE family protein 3325389 PPE46 7562887 PPE46 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002646081.1 3324076 R 561275 CDS YP_002646083.1 224991394 7561728 complement(3325792..3326082) 1 NC_012207.1 EsaT-6 like protein 9 3326082 esxR 7561728 esxR Mycobacterium bovis BCG str. Tokyo 172 EsaT-6 like protein 9 YP_002646083.1 3325792 R 561275 CDS YP_002646084.1 224991395 7562888 complement(3326117..3326410) 1 NC_012207.1 PE family protein 3326410 esxS 7562888 esxS Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002646084.1 3326117 R 561275 CDS YP_002646085.1 224991396 7562889 complement(3326457..3327764) 1 NC_012207.1 In Mycobacterium tuberculosis H37Rv, PPE47 and PPE48 exist as 2 separate genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-G) leads to a single product.; PPE family protein 3327764 PPE47 7562889 PPE47 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002646085.1 3326457 R 561275 CDS YP_002646086.1 224991397 7562185 complement(3327761..3328075) 1 NC_012207.1 PE family protein 3328075 PE29 7562185 PE29 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002646086.1 3327761 R 561275 CDS YP_002646087.1 224991398 7561729 complement(3328457..3329704) 1 NC_012207.1 Differs from Rv3023c by 1aa T9A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transposase 3329704 7561729 JTY_3041 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646087.1 3328457 R 561275 CDS YP_002646088.1 224991399 7562718 complement(3329867..3330970) 1 NC_012207.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 3330970 mnmA 7562718 mnmA Mycobacterium bovis BCG str. Tokyo 172 tRNA-specific 2-thiouridylase MnmA YP_002646088.1 3329867 R 561275 CDS YP_002646089.1 224991400 7561627 complement(3330967..3332148) 1 NC_012207.1 cysteine desulfurase 3332148 iscS 7561627 iscS Mycobacterium bovis BCG str. Tokyo 172 cysteine desulfurase YP_002646089.1 3330967 R 561275 CDS YP_002646090.1 224991401 7562793 complement(3332245..3333159) 1 NC_012207.1 hypothetical protein 3333159 7562793 JTY_3044 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646090.1 3332245 R 561275 CDS YP_002646091.1 224991402 7562719 complement(3333156..3333896) 1 NC_012207.1 hypothetical protein 3333896 7562719 JTY_3045 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646091.1 3333156 R 561275 CDS YP_002646092.1 224991403 7562720 complement(3334157..3335113) 1 NC_012207.1 Differs from Rv3028c by 1aa, V312A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; electron transfer flavoprotein alpha-subunit 3335113 fixB 7562720 fixB Mycobacterium bovis BCG str. Tokyo 172 electron transfer flavoprotein alpha-subunit YP_002646092.1 3334157 R 561275 CDS YP_002646093.1 224991404 7563416 complement(3335152..3335952) 1 NC_012207.1 electron transfer flavoprotein beta-subunit 3335952 fixA 7563416 fixA Mycobacterium bovis BCG str. Tokyo 172 electron transfer flavoprotein beta-subunit YP_002646093.1 3335152 R 561275 CDS YP_002646094.1 224991405 7563415 3336183..3337007 1 NC_012207.1 hypothetical protein 3337007 7563415 JTY_3048 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646094.1 3336183 D 561275 CDS YP_002646095.1 224991406 7562721 3337004..3338584 1 NC_012207.1 hypothetical protein 3338584 7562721 JTY_3049 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646095.1 3337004 D 561275 CDS YP_002646096.1 224991407 7562722 3338616..3339860 1 NC_012207.1 Differs from Rv3032 and Mb3058 by 1aa, P380Q in BCG Pasteur and BCG Tokyo; transferase 3339860 7562722 JTY_3050 Mycobacterium bovis BCG str. Tokyo 172 transferase YP_002646096.1 3338616 D 561275 CDS YP_002646097.1 224991408 7562723 3339894..3340283 1 NC_012207.1 hypothetical protein 3340283 7562723 JTY_3051 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646097.1 3339894 D 561275 CDS YP_002646098.1 224991409 7562724 3340462..3341010 1 NC_012207.1 hypothetical protein 3341010 7562724 JTY_3052 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646098.1 3340462 D 561275 CDS YP_002646099.1 224991410 7562725 complement(3341101..3342003) 1 NC_012207.1 transferase 3342003 7562725 JTY_3053 Mycobacterium bovis BCG str. Tokyo 172 transferase YP_002646099.1 3341101 R 561275 CDS YP_002646100.1 224991411 7562726 3342461..3343543 1 NC_012207.1 hypothetical protein 3343543 7562726 JTY_3054 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646100.1 3342461 D 561275 CDS YP_002646101.1 224991412 7562727 complement(3343540..3344223) 1 NC_012207.1 Differs from Mb3062c by 1aa, Q63R in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3344223 TB22.2 7562727 TB22.2 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646101.1 3343540 R 561275 CDS YP_002646102.1 224991413 7561832 complement(3344296..3345372) 1 NC_012207.1 Differs from Rv3037c by 1aa, A7D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3345372 7561832 JTY_3056 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646102.1 3344296 R 561275 CDS YP_002646103.1 224991414 7562728 complement(3345507..3346490) 1 NC_012207.1 hypothetical protein 3346490 7562728 JTY_3057 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646103.1 3345507 R 561275 CDS YP_002646104.1 224991415 7562729 complement(3346501..3347265) 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 3347265 echA17 7562729 echA17 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002646104.1 3346501 R 561275 CDS YP_002646105.1 224991416 7561528 complement(3347274..3348140) 1 NC_012207.1 hypothetical protein 3348140 7561528 JTY_3059 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646105.1 3347274 R 561275 CDS YP_002646106.1 224991417 7562730 complement(3348137..3349000) 1 NC_012207.1 ATP-binding protein ABC transporter 3349000 7562730 JTY_3060 Mycobacterium bovis BCG str. Tokyo 172 ATP-binding protein ABC transporter YP_002646106.1 3348137 R 561275 CDS YP_002646107.1 224991418 7562731 complement(3349015..3350244) 1 NC_012207.1 Differs from Rv3042c by 2aa, S70A, E116G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; phosphoserine phosphatase 3350244 serB2 7562731 serB2 Mycobacterium bovis BCG str. Tokyo 172 phosphoserine phosphatase YP_002646107.1 3349015 R 561275 CDS YP_002646108.1 224991419 7560782 complement(3350282..3352003) 1 NC_012207.1 cytochrome c oxidase polypeptide I 3352003 ctaD 7560782 ctaD Mycobacterium bovis BCG str. Tokyo 172 cytochrome c oxidase polypeptide I YP_002646108.1 3350282 R 561275 CDS YP_002646109.1 224991420 7563129 3352218..3353297 1 NC_012207.1 FeIII-dicitrate-binding periplasmic lipoprotein 3353297 fecB 7563129 fecB Mycobacterium bovis BCG str. Tokyo 172 FeIII-dicitrate-binding periplasmic lipoprotein YP_002646109.1 3352218 D 561275 CDS YP_002646110.1 224991421 7563410 3353367..3354407 1 NC_012207.1 NADP-dependent alcohol dehydrogenase 3354407 adhC 7563410 adhC Mycobacterium bovis BCG str. Tokyo 172 NADP-dependent alcohol dehydrogenase YP_002646110.1 3353367 D 561275 CDS YP_002646111.1 224991422 7563943 complement(3354396..3354770) 1 NC_012207.1 hypothetical protein 3354770 7563943 JTY_3065 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646111.1 3354396 R 561275 CDS YP_002646112.1 224991423 7562732 complement(3355104..3355388) 1 NC_012207.1 hypothetical protein 3355388 7562732 JTY_3066 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646112.1 3355104 R 561275 CDS YP_002646113.1 224991424 7562733 complement(3355486..3356460) 1 NC_012207.1 ribonucleotide-diphosphate reductase subunit beta 3356460 nrdF2 7562733 nrdF2 Mycobacterium bovis BCG str. Tokyo 172 ribonucleotide-diphosphate reductase subunit beta YP_002646113.1 3355486 R 561275 CDS YP_002646114.1 224991425 7562467 complement(3356591..3358165) 1 NC_012207.1 monooxygenase 3358165 7562467 JTY_3068 Mycobacterium bovis BCG str. Tokyo 172 monooxygenase YP_002646114.1 3356591 R 561275 CDS YP_002646115.1 224991426 7562734 complement(3358299..3359039) 1 NC_012207.1 probably AsnC-family; transcriptional regulatory protein 3359039 7562734 JTY_3069 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646115.1 3358299 R 561275 CDS YP_002646116.1 224991427 7562735 complement(3359167..3361248) 1 NC_012207.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 3361248 nrdE 7562735 nrdE Mycobacterium bovis BCG str. Tokyo 172 ribonucleotide-diphosphate reductase subunit alpha YP_002646116.1 3359167 R 561275 CDS YP_002646117.1 224991428 7562465 complement(3361314..3361766) 1 NC_012207.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 3361766 nrdI 7562465 nrdI Mycobacterium bovis BCG str. Tokyo 172 ribonucleotide reductase stimulatory protein YP_002646117.1 3361314 R 561275 CDS YP_002646118.1 224991429 7562469 complement(3361801..3362040) 1 NC_012207.1 glutaredoxin-like protein; glutaredoxin electron transport component of nrdEF 3362040 nrdH 7562469 nrdH Mycobacterium bovis BCG str. Tokyo 172 glutaredoxin electron transport component of nrdEF YP_002646118.1 3361801 R 561275 CDS YP_002646119.1 224991430 7562468 complement(3362018..3362386) 1 NC_012207.1 hypothetical protein 3362386 7562468 JTY_3073 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646119.1 3362018 R 561275 CDS YP_002646120.1 224991431 7562736 complement(3362503..3363057) 1 NC_012207.1 hypothetical protein 3363057 7562736 JTY_3074 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646120.1 3362503 R 561275 CDS YP_002646121.1 224991432 7562737 3363149..3363763 1 NC_012207.1 probably TetR-family; transcriptional regulatory protein 3363763 7562737 JTY_3075 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646121.1 3363149 D 561275 CDS YP_002646122.1 224991433 7562738 3363773..3364813 1 NC_012207.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 3364813 dinP 7562738 dinP Mycobacterium bovis BCG str. Tokyo 172 DNA polymerase IV YP_002646122.1 3363773 D 561275 CDS YP_002646123.1 224991434 7561495 complement(3364867..3365730) 1 NC_012207.1 short chain dehydrogenase 3365730 7561495 JTY_3077 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002646123.1 3364867 R 561275 CDS YP_002646124.1 224991435 7562739 complement(3365794..3366444) 1 NC_012207.1 probably TetR-family; transcriptional regulatory protein 3366444 7562739 JTY_3078 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646124.1 3365794 R 561275 CDS YP_002646125.1 224991436 7562740 3366560..3368038 1 NC_012207.1 Differs from Mb3085 by 1aa, E44K and Rv3059 by 2aa, E44K, G445D in BCG Pasteur and BCG Tokyo; cytochrome P450 136 3368038 cyp136 7562740 cyp136 Mycobacterium bovis BCG str. Tokyo 172 cytochrome P450 136 YP_002646125.1 3366560 D 561275 CDS YP_002646126.1 224991437 7563162 complement(3368809..3370281) 1 NC_012207.1 probably GntR-family; transcriptional regulatory protein 3370281 7563162 JTY_3080 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646126.1 3368809 R 561275 CDS YP_002646127.1 224991438 7562741 complement(3370398..3372563) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, fadE22 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-C) splits fadE22 into 2 parts, fadE22a and fadE22b. Differs from Mb3087c and from Rv3061c by 2aa, E488K, C497S in BCG Pasteur and BCG Tokyo; acyl-CoA dehydrogenase 3372563 fadE22 7562741 fadE22 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002646127.1 3370398 R 561275 CDS YP_002646128.1 224991439 7563371 3372720..3374243 1 NC_012207.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; ATP-dependent DNA ligase 3374243 ligB 7563371 ligB Mycobacterium bovis BCG str. Tokyo 172 ATP-dependent DNA ligase YP_002646128.1 3372720 D 561275 CDS YP_002646129.1 224991440 7562827 3374379..3376655 1 NC_012207.1 Differs from Rv3063 by 3aa, C402G, S559R, P600L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; carbon starvation protein A homolog 3376655 cstA 7562827 cstA Mycobacterium bovis BCG str. Tokyo 172 carbon starvation protein A homolog YP_002646129.1 3374379 D 561275 CDS YP_002646130.1 224991441 7563126 complement(3376961..3377386) 1 NC_012207.1 integral membrane protein 3377386 7563126 JTY_3084 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002646130.1 3376961 R 561275 CDS YP_002646131.1 224991442 7562742 3377523..3377846 1 NC_012207.1 multidrug-transport integral membrane protein 3377846 mmr 7562742 mmr Mycobacterium bovis BCG str. Tokyo 172 multidrug-transport integral membrane protein YP_002646131.1 3377523 D 561275 CDS YP_002646132.1 224991443 7563517 3377843..3378451 1 NC_012207.1 probably DeoR-family; transcriptional regulatory protein 3378451 7563517 JTY_3086 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646132.1 3377843 D 561275 CDS YP_002646133.1 224991444 7562743 3378564..3378974 1 NC_012207.1 Differs from Rv3067 and Mb3094 by 1aa A3T in BCG Pasteur and BCG Tokyo; hypothetical protein 3378974 7562743 JTY_3087 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646133.1 3378564 D 561275 CDS YP_002646134.1 224991445 7563956 complement(3379115..3380758) 1 NC_012207.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 3380758 pgmA 7563956 pgmA Mycobacterium bovis BCG str. Tokyo 172 phosphoglucomutase YP_002646134.1 3379115 R 561275 CDS YP_002646135.1 224991446 7562400 3380828..3381226 1 NC_012207.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 3381226 7562400 JTY_3089 Mycobacterium bovis BCG str. Tokyo 172 camphor resistance protein CrcB YP_002646135.1 3380828 D 561275 CDS YP_002646136.1 224991447 7562745 3381223..3381603 1 NC_012207.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 3381603 7562745 JTY_3090 Mycobacterium bovis BCG str. Tokyo 172 camphor resistance protein CrcB YP_002646136.1 3381223 D 561275 CDS YP_002646137.1 224991448 7562746 3381600..3382709 1 NC_012207.1 hypothetical protein 3382709 7562746 JTY_3091 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646137.1 3381600 D 561275 CDS YP_002646138.1 224991449 7562747 complement(3382934..3383458) 1 NC_012207.1 hypothetical protein 3383458 7562747 JTY_3092 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646138.1 3382934 R 561275 CDS YP_002646139.1 224991450 7562748 complement(3383465..3383821) 1 NC_012207.1 hypothetical protein 3383821 7562748 JTY_3093 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646139.1 3383465 R 561275 CDS YP_002646140.1 224991451 7562749 3383915..3385189 1 NC_012207.1 hypothetical protein 3385189 7562749 JTY_3094 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646140.1 3383915 D 561275 CDS YP_002646141.1 224991452 7562750 complement(3385186..3386109) 1 NC_012207.1 hypothetical protein 3386109 7562750 JTY_3095 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646141.1 3385186 R 561275 CDS YP_002646142.1 224991453 7562751 3386208..3386684 1 NC_012207.1 hypothetical protein 3386684 7562751 JTY_3096 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646142.1 3386208 D 561275 CDS YP_002646143.1 224991454 7562752 3386677..3388488 1 NC_012207.1 Differs from Rv3077 by 1aa R311G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrolase 3388488 7562752 JTY_3097 Mycobacterium bovis BCG str. Tokyo 172 hydrolase YP_002646143.1 3386677 D 561275 CDS YP_002646144.1 224991455 7562753 3388489..3388890 1 NC_012207.1 hydroxylaminobenzene mutase 3388890 hab 7562753 hab Mycobacterium bovis BCG str. Tokyo 172 hydroxylaminobenzene mutase YP_002646144.1 3388489 D 561275 CDS YP_002646145.1 224991456 7563293 complement(3388906..3389733) 1 NC_012207.1 hypothetical protein 3389733 7563293 JTY_3099 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646145.1 3388906 R 561275 CDS YP_002646146.1 224991457 7562754 complement(3389792..3393124) 1 NC_012207.1 Differs from Rv3080c by 1aa, V217A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; serine/threonine-protein kinase transcriptional regulatory protein 3393124 pknK 7562754 pknK Mycobacterium bovis BCG str. Tokyo 172 serine/threonine-protein kinase transcriptional regulatory protein YP_002646146.1 3389792 R 561275 CDS YP_002646147.1 224991458 7562438 3393176..3394414 1 NC_012207.1 Differs from Rv3081 and Mb3108 by 1aa, A108V in BCG Pasteur and BCG Tokyo; hypothetical protein 3394414 7562438 JTY_3101 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646147.1 3393176 D 561275 CDS YP_002646148.1 224991459 7562755 complement(3394540..3395562) 1 NC_012207.1 AraC/XylS family; Differs from Rv3082c by 1aa, C322R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; virulence-regulating transcriptional regulator 3395562 virS 7562755 virS Mycobacterium bovis BCG str. Tokyo 172 virulence-regulating transcriptional regulator YP_002646148.1 3394540 R 561275 CDS YP_002646149.1 224991460 7561681 3395640..3397127 1 NC_012207.1 Differs from Mb3110 by 1aa, S81I and from Rv3083 by 2aa, S81I, I94V in BCG Pasteur and BCG Tokyo; monooxygenase 3397127 7561681 JTY_3103 Mycobacterium bovis BCG str. Tokyo 172 monooxygenase YP_002646149.1 3395640 D 561275 CDS YP_002646150.1 224991461 7562756 3397133..3398059 1 NC_012207.1 Differs from Rv3084 and Mb3111 by 1aa, G276S in BCG Pasteur and BCG Tokyo; acetyl-hydrolase/esterase 3398059 lipR 7562756 lipR Mycobacterium bovis BCG str. Tokyo 172 acetyl-hydrolase/esterase YP_002646150.1 3397133 D 561275 CDS YP_002646151.1 224991462 7562845 3398056..3398886 1 NC_012207.1 short-chain type dehydrogenase/reductase 3398886 7562845 JTY_3105 Mycobacterium bovis BCG str. Tokyo 172 short-chain type dehydrogenase/reductase YP_002646151.1 3398056 D 561275 CDS YP_002646152.1 224991463 7562757 3398917..3400023 1 NC_012207.1 zinc-type alcohol dehydrogenase 3400023 adhD 7562757 adhD Mycobacterium bovis BCG str. Tokyo 172 zinc-type alcohol dehydrogenase YP_002646152.1 3398917 D 561275 CDS YP_002646153.1 224991464 7563944 3400061..3401479 1 NC_012207.1 Differs from Rv3087 by 1aa, V447L, and from Mb3114 by 1aa, T158A in BCG Pasteur and BCG Tokyo; hypothetical protein 3401479 7563944 JTY_3107 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646153.1 3400061 D 561275 CDS YP_002646154.1 224991465 7562758 3401476..3402900 1 NC_012207.1 hypothetical protein 3402900 7562758 JTY_3108 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646154.1 3401476 D 561275 CDS YP_002646155.1 224991466 7562759 3402897..3404408 1 NC_012207.1 chain-fatty-acid-CoA ligase 3404408 fadD13 7562759 fadD13 Mycobacterium bovis BCG str. Tokyo 172 chain-fatty-acid-CoA ligase YP_002646155.1 3402897 D 561275 CDS YP_002646156.1 224991467 7562919 3405347..3406234 1 NC_012207.1 hypothetical alanine and valine rich protein 3406234 7562919 JTY_3110 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine and valine rich protein YP_002646156.1 3405347 D 561275 CDS YP_002646157.1 224991468 7562760 3406252..3407943 1 NC_012207.1 hypothetical protein 3407943 7562760 JTY_3111 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646157.1 3406252 D 561275 CDS YP_002646158.1 224991469 7562761 complement(3407950..3408870) 1 NC_012207.1 Differs from Mb3119c by 1 aa, I237M in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein 3408870 7562761 JTY_3112 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002646158.1 3407950 R 561275 CDS YP_002646159.1 224991470 7562762 complement(3408896..3409900) 1 NC_012207.1 Differs from Rv3093c by 1aa W210C in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; oxidoreductase 3409900 7562762 JTY_3113 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646159.1 3408896 R 561275 CDS YP_002646160.1 224991471 7562763 complement(3409897..3411027) 1 NC_012207.1 hypothetical protein 3411027 7562763 JTY_3114 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646160.1 3409897 R 561275 CDS YP_002646161.1 224991472 7562764 3411109..3411585 1 NC_012207.1 hypothetical transcriptional regulatory protein 3411585 7562764 JTY_3115 Mycobacterium bovis BCG str. Tokyo 172 hypothetical transcriptional regulatory protein YP_002646161.1 3411109 D 561275 CDS YP_002646162.1 224991473 7562765 3411683..3412822 1 NC_012207.1 Differs from Rv3097 by 1aa G28E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3412822 7562765 JTY_3116 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646162.1 3411683 D 561275 CDS YP_002646163.1 224991474 7562766 complement(3412914..3414227) 1 NC_012207.1 Differs from Rv3097c by 1aa A58G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably triacyl glycerol lipase; PE-PGRS family protein 3414227 PE_PGRS63 7562766 PE_PGRS63 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002646163.1 3412914 R 561275 CDS YP_002646164.1 224991475 7562389 complement(3414346..3414798) 1 NC_012207.1 Differs from Rv3098c by 1aa E117D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3414798 7562389 JTY_3118 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646164.1 3414346 R 561275 CDS YP_002646165.1 224991476 7564321 complement(3415549..3416400) 1 NC_012207.1 hypothetical protein 3416400 7564321 JTY_3119 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646165.1 3415549 R 561275 CDS YP_002646166.1 224991477 7562768 complement(3416437..3416919) 1 NC_012207.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 3416919 smpB 7562768 smpB Mycobacterium bovis BCG str. Tokyo 172 SsrA-binding protein YP_002646166.1 3416437 R 561275 CDS YP_002646167.1 224991478 7561801 complement(3416922..3417815) 1 NC_012207.1 Differs from Rv3101c by 1aa, S171N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cell division protein 3417815 ftsX 7561801 ftsX Mycobacterium bovis BCG str. Tokyo 172 cell division protein YP_002646167.1 3416922 R 561275 CDS YP_002646168.1 224991479 7561881 complement(3417816..3418505) 1 NC_012207.1 cell division ATP-binding protein 3418505 ftsE 7561881 ftsE Mycobacterium bovis BCG str. Tokyo 172 cell division ATP-binding protein YP_002646168.1 3417816 R 561275 CDS YP_002646169.1 224991480 7561876 complement(3418549..3418986) 1 NC_012207.1 hypothetical protein 3418986 7561876 JTY_3123 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646169.1 3418549 R 561275 CDS YP_002646170.1 224991481 7562769 complement(3418988..3419914) 1 NC_012207.1 transmembrane protein 3419914 7562769 JTY_3124 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646170.1 3418988 R 561275 CDS YP_002646171.1 224991482 7562770 complement(3419904..3421040) 1 NC_012207.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 3421040 prfB 7562770 prfB Mycobacterium bovis BCG str. Tokyo 172 peptide chain release factor 2 YP_002646171.1 3419904 R 561275 CDS YP_002646172.1 224991483 7560822 3421144..3422514 1 NC_012207.1 Differs from Rv3106 by 2aa, I141V, D385N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; NADPH:adrenodoxin oxidoreductase 3422514 fprA 7560822 fprA Mycobacterium bovis BCG str. Tokyo 172 NADPH:adrenodoxin oxidoreductase YP_002646172.1 3421144 D 561275 CDS YP_002646173.1 224991484 7563427 complement(3422515..3424098) 1 NC_012207.1 alkyldihydroxyacetonephosphate synthase 3424098 agpS 7563427 agpS Mycobacterium bovis BCG str. Tokyo 172 alkyldihydroxyacetonephosphate synthase YP_002646173.1 3422515 R 561275 CDS YP_002646174.1 224991485 7563950 3424197..3424637 1 NC_012207.1 Differs from Mb3135 by 1aa I145V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3424637 7563950 JTY_3128 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646174.1 3424197 D 561275 CDS YP_002646175.1 224991486 7562771 3424786..3425865 1 NC_012207.1 Differs from Mb3136 by 1aa, T324A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; molybdenum cofactor biosynthesis protein A 3425865 moaA1 7562771 moaA1 Mycobacterium bovis BCG str. Tokyo 172 molybdenum cofactor biosynthesis protein A YP_002646175.1 3424786 D 561275 CDS YP_002646176.1 224991487 7563523 3425916..3426311 1 NC_012207.1 pterin-4-alpha-carbinolamine dehydratase 3426311 moaB1 7563523 moaB1 Mycobacterium bovis BCG str. Tokyo 172 pterin-4-alpha-carbinolamine dehydratase YP_002646176.1 3425916 D 561275 CDS YP_002646177.1 224991488 7563525 3426308..3426820 1 NC_012207.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 3426820 moaC 7563525 moaC Mycobacterium bovis BCG str. Tokyo 172 molybdenum cofactor biosynthesis protein MoaC YP_002646177.1 3426308 D 561275 CDS YP_002646178.1 224991489 7563528 3426837..3427088 1 NC_012207.1 molybdenum cofactor biosynthesis protein D 3427088 moaD1 7563528 moaD1 Mycobacterium bovis BCG str. Tokyo 172 molybdenum cofactor biosynthesis protein D YP_002646178.1 3426837 D 561275 CDS YP_002646179.1 224991490 7563531 3427210..3427878 1 NC_012207.1 Differs from Rv3113 by 3aa, C11W, E134G, R191L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; phosphatase 3427878 7563531 JTY_3133 Mycobacterium bovis BCG str. Tokyo 172 phosphatase YP_002646179.1 3427210 D 561275 CDS YP_002646180.1 224991491 7562772 3427895..3428425 1 NC_012207.1 Differs from Rv3114 by 1aa, P11S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3428425 7562772 JTY_3134 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646180.1 3427895 D 561275 CDS YP_002646181.1 224991492 7562773 3428587..3429834 1 NC_012207.1 transposase 3429834 7562773 JTY_3135 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646181.1 3428587 D 561275 CDS YP_002646182.1 224991493 7561286 3429912..3431081 1 NC_012207.1 molybdenum cofactor biosynthesis protein 3431081 moeB2 7561286 moeB2 Mycobacterium bovis BCG str. Tokyo 172 molybdenum cofactor biosynthesis protein YP_002646182.1 3429912 D 561275 CDS YP_002646183.1 224991494 7563542 3431110..3432072 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a large deletion of 2775 bp (RD12) leads to the loss of the COOH part of cysA3, the following CDSs, sseC1, moaE1, Rv3120 and a large part of cyp141 except the COOH end, compared to the homolog in Mycobacterium tuberculosis strain H37Rv; thiosulfate sulfurtransferase 3432072 cysA3 7563542 cysA3 Mycobacterium bovis BCG str. Tokyo 172 thiosulfate sulfurtransferase YP_002646183.1 3431110 D 561275 CDS YP_002646184.1 224991495 7563174 3432450..3432920 1 NC_012207.1 Differs from Rv3122 by 1aa, S156R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3432920 7563174 JTY_3138 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646184.1 3432450 D 561275 CDS YP_002646185.1 224991496 7561287 3432930..3433424 1 NC_012207.1 Differs from Rv3123 by 1aa, Q40R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3433424 7561287 JTY_3139 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646185.1 3432930 D 561275 CDS YP_002646186.1 224991497 7561288 3433867..3434736 1 NC_012207.1 Differs from Rv3124 and Mb3147 by 1aa, G159E in BCG Pasteur and BCG Tokyo; transcriptional regulatory protein 3434736 7561288 JTY_3140 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646186.1 3433867 D 561275 CDS YP_002646187.1 224991498 7561289 complement(3434837..3435151) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur and BCG Tokyo, PPE49 has incurred a single base deletion in codon 272 compared to Rv3125c and Mb3148c leading to frameshift, and two products of 282 and 104 aa, compared to 391 in others; PPE family protein 3435151 PPE49b 7561289 PPE49b Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002646187.1 3434837 R 561275 CDS YP_002646188.1 224991499 7562187 complement(3435163..3436011) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur and BCG Tokyo, PPE49 has incurred a single base deletion in codon 272 compared to Rv3125c and Mb3148c leading to frameshift, and two products of 282 and 104 aa, compared to 391 in others. Differs from Rv3125c by 1aa, V38A; PPE family protein 3436011 PPE49a 7562187 PPE49a Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002646188.1 3435163 R 561275 CDS YP_002646189.1 224991500 7562186 complement(3436168..3436482) 1 NC_012207.1 hypothetical protein 3436482 7562186 JTY_3143 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646189.1 3436168 R 561275 CDS YP_002646190.1 224991501 7561290 3436507..3437541 1 NC_012207.1 Differs from Rv3127 by 1aa, C95F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3437541 7561290 JTY_3144 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646190.1 3436507 D 561275 CDS YP_002646191.1 224991502 7561291 complement(3437528..3437878) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv3128c exists as a single gene with an in-frame amber stop codon. In Mycobacterium bovis, BCG Pasteur, and BCG Tokyo, Rv3128c is split into 2, Mb3151c and Mb3152c; hypothetical protein 3437878 7561291 JTY_3145 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646191.1 3437528 R 561275 CDS YP_002646192.1 224991503 7561292 complement(3437960..3438541) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv3128c exists as a single gene with an in-frame amber stop codon. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, Rv3128c is split into 2 genes. Differs from Mb3152c by 1aa, V166G in BCG Pasteur and BCG Tokyo; hypothetical protein 3438541 7561292 JTY_3146 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646192.1 3437960 R 561275 CDS YP_002646193.1 224991504 7561293 3439020..3439352 1 NC_012207.1 hypothetical protein 3439352 7561293 JTY_3147 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646193.1 3439020 D 561275 CDS YP_002646194.1 224991505 7561294 complement(3439335..3440726) 1 NC_012207.1 hypothetical protein 3440726 7561294 JTY_3148 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646194.1 3439335 R 561275 CDS YP_002646195.1 224991506 7561295 3440911..3441909 1 NC_012207.1 hypothetical protein 3441909 7561295 JTY_3149 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646195.1 3440911 D 561275 CDS YP_002646196.1 224991507 7561296 complement(3441889..3443625) 1 NC_012207.1 Differs from Rv3132c by 1aa, T283I in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; two component sensor histidine kinase 3443625 devS 7561296 devS Mycobacterium bovis BCG str. Tokyo 172 two component sensor histidine kinase YP_002646196.1 3441889 R 561275 CDS YP_002646197.1 224991508 7561488 complement(3443622..3444275) 1 NC_012207.1 probably LuxR/UhpA-family; two component transcriptional regulatory protein 3444275 devR 7561488 devR Mycobacterium bovis BCG str. Tokyo 172 two component transcriptional regulatory protein YP_002646197.1 3443622 R 561275 CDS YP_002646198.1 224991509 7561487 complement(3444303..3445109) 1 NC_012207.1 hypothetical protein 3445109 7561487 JTY_3152 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646198.1 3444303 R 561275 CDS YP_002646199.1 224991510 7561297 3445694..3446839 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a large 1337 bp insertion (I-RD08) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (381 aa versus 132 aa). Differs from Mb3159 by 1aa, K213E in BCG Pasteur. Differ from Mb3159 by 1aa, G256E in BCG Tokyo; PPE family protein 3446839 PPE50 7561297 PPE50 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002646199.1 3445694 D 561275 CDS YP_002646200.1 224991511 7562189 3447491..3448633 1 NC_012207.1 PPE family protein 3448633 PPE51 7562189 PPE51 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002646200.1 3447491 D 561275 CDS YP_002646201.1 224991512 7562190 3449090..3449872 1 NC_012207.1 Differs from Rv3137 by 1aa, L168P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; monophosphatase 3449872 7562190 JTY_3155 Mycobacterium bovis BCG str. Tokyo 172 monophosphatase YP_002646201.1 3449090 D 561275 CDS YP_002646202.1 224991513 7561298 3449892..3450980 1 NC_012207.1 Differs from Rv3138 by 2aa, N110S, P271T, and from Mb3162 by 2aa, F257S, P270L in BCG Pasteur and BCG Tokyo; pyruvate formate lyase activating protein 3450980 pflA 7561298 pflA Mycobacterium bovis BCG str. Tokyo 172 pyruvate formate lyase activating protein YP_002646202.1 3449892 D 561275 CDS YP_002646203.1 224991514 7562397 3451060..3452466 1 NC_012207.1 acyl-CoA dehydrogenase 3452466 fadE24 7562397 fadE24 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002646203.1 3451060 D 561275 CDS YP_002646204.1 224991515 7563373 3452487..3453692 1 NC_012207.1 acyl-CoA dehydrogenase 3453692 fadE23 7563373 fadE23 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002646204.1 3452487 D 561275 CDS YP_002646205.1 224991516 7563372 3453792..3454763 1 NC_012207.1 NADPH quinone oxidoreductase 3454763 fadB4 7563372 fadB4 Mycobacterium bovis BCG str. Tokyo 172 NADPH quinone oxidoreductase YP_002646205.1 3453792 D 561275 CDS YP_002646206.1 224991517 7562913 complement(3454815..3455243) 1 NC_012207.1 Differs from Mb3166c by 1aa, H133Q in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3455243 7562913 JTY_3160 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646206.1 3454815 R 561275 CDS YP_002646207.1 224991518 7561299 3455351..3455752 1 NC_012207.1 response regulator 3455752 7561299 JTY_3161 Mycobacterium bovis BCG str. Tokyo 172 response regulator YP_002646207.1 3455351 D 561275 CDS YP_002646208.1 224991519 7561300 complement(3455785..3457014) 1 NC_012207.1 Differs from Rv3144c by 1aa, G226S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PPE family protein 3457014 PPE52 7561300 PPE52 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002646208.1 3455785 R 561275 CDS YP_002646209.1 224991520 7562191 3457379..3457765 1 NC_012207.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 3457765 nuoA 7562191 nuoA Mycobacterium bovis BCG str. Tokyo 172 NADH dehydrogenase subunit A YP_002646209.1 3457379 D 561275 CDS YP_002646210.1 224991521 7562474 3457774..3458328 1 NC_012207.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 3458328 nuoB 7562474 nuoB Mycobacterium bovis BCG str. Tokyo 172 NADH dehydrogenase subunit B YP_002646210.1 3457774 D 561275 CDS YP_002646211.1 224991522 7562475 3458325..3459035 1 NC_012207.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit C 3459035 nuoC 7562475 nuoC Mycobacterium bovis BCG str. Tokyo 172 NADH dehydrogenase subunit C YP_002646211.1 3458325 D 561275 CDS YP_002646212.1 224991523 7562476 3459035..3460357 1 NC_012207.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 3460357 nuoD 7562476 nuoD Mycobacterium bovis BCG str. Tokyo 172 NADH dehydrogenase subunit D YP_002646212.1 3459035 D 561275 CDS YP_002646213.1 224991524 7562477 3460354..3461112 1 NC_012207.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 3461112 nuoE 7562477 nuoE Mycobacterium bovis BCG str. Tokyo 172 NADH dehydrogenase subunit E YP_002646213.1 3460354 D 561275 CDS YP_002646214.1 224991525 7562478 3461109..3462446 1 NC_012207.1 NADH dehydrogenase I chain F 3462446 nuoF 7562478 nuoF Mycobacterium bovis BCG str. Tokyo 172 NADH dehydrogenase I chain F YP_002646214.1 3461109 D 561275 CDS YP_002646215.1 224991526 7562479 3462443..3464863 1 NC_012207.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 3464863 nuoG 7562479 nuoG Mycobacterium bovis BCG str. Tokyo 172 NADH dehydrogenase subunit G YP_002646215.1 3462443 D 561275 CDS YP_002646216.1 224991527 7562480 3464979..3466211 1 NC_012207.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 3466211 nuoH 7562480 nuoH Mycobacterium bovis BCG str. Tokyo 172 NADH dehydrogenase subunit H YP_002646216.1 3464979 D 561275 CDS YP_002646217.1 224991528 7562481 3466204..3466839 1 NC_012207.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 3466839 nuoI 7562481 nuoI Mycobacterium bovis BCG str. Tokyo 172 NADH dehydrogenase subunit I YP_002646217.1 3466204 D 561275 CDS YP_002646218.1 224991529 7562482 3466836..3467624 1 NC_012207.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 3467624 nuoJ 7562482 nuoJ Mycobacterium bovis BCG str. Tokyo 172 NADH dehydrogenase subunit J YP_002646218.1 3466836 D 561275 CDS YP_002646219.1 224991530 7562483 3467621..3467920 1 NC_012207.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 3467920 nuoK 7562483 nuoK Mycobacterium bovis BCG str. Tokyo 172 NADH dehydrogenase subunit K YP_002646219.1 3467621 D 561275 CDS YP_002646220.1 224991531 7562484 3467931..3469832 1 NC_012207.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 3469832 nuoL 7562484 nuoL Mycobacterium bovis BCG str. Tokyo 172 NADH dehydrogenase subunit L YP_002646220.1 3467931 D 561275 CDS YP_002646221.1 224991532 7562485 3469829..3471490 1 NC_012207.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 3471490 nuoM 7562485 nuoM Mycobacterium bovis BCG str. Tokyo 172 NADH dehydrogenase subunit M YP_002646221.1 3469829 D 561275 CDS YP_002646222.1 224991533 7562486 3471487..3473082 1 NC_012207.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 3473082 nuoN 7562486 nuoN Mycobacterium bovis BCG str. Tokyo 172 NADH dehydrogenase subunit N YP_002646222.1 3471487 D 561275 CDS YP_002646223.1 224991534 7562487 complement(3473088..3474857) 1 NC_012207.1 In Mycobacterium bovis BCG pasteur, BCG Tokyo, and Mycobacterium bovis, albeit a 2146 bp insertion occurs overlapping the NH2-terminal part, this leads to an equivalent product, compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Rv3159c by 2aa, deletion of A64, V87A, and from Mb3183c by 1aa, V87A in BCG Pasteur and BCG Tokyo.; PPE family protein 3474857 PPE53 7562487 PPE53 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002646223.1 3473088 R 561275 CDS YP_002646224.1 224991535 7562192 complement(3475105..3477006) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, an insertion of 2146 bp exists between PPE53 and Rv3160c compared to Mycobacterium tuberculosis strain H37Rv. This leads to an additional gene, PPE70 equivalent to MT3248 from Mycobacterium tuberculosis strain CDC1551. Differs from Mb3184c by 1aa, addition of A64 in BCG Pasteur and BCG Tokyo.; PPE family protein 3477006 PPE70 7562192 PPE70 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002646224.1 3475105 R 561275 CDS YP_002646225.1 224991536 7560801 complement(3477181..3477822) 1 NC_012207.1 probably TetR-family; transcriptional regulatory protein 3477822 7560801 JTY_3179 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646225.1 3477181 R 561275 CDS YP_002646226.1 224991537 7561301 complement(3477833..3478981) 1 NC_012207.1 Differs from Rv3161c by 1aa, L62V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; dioxygenase 3478981 7561301 JTY_3180 Mycobacterium bovis BCG str. Tokyo 172 dioxygenase YP_002646226.1 3477833 R 561275 CDS YP_002646227.1 224991538 7561302 complement(3478897..3479487) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (T-*), leads to a longer product with different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; integral membrane protein 3479487 7561302 JTY_3181 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002646227.1 3478897 R 561275 CDS YP_002646228.1 224991539 7561303 complement(3479484..3480755) 1 NC_012207.1 Differs from Mb3188c by 1aa, D341E in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3480755 7561303 JTY_3182 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646228.1 3479484 R 561275 CDS YP_002646229.1 224991540 7561304 complement(3480785..3481747) 1 NC_012207.1 Differs from Mb3189c by 1aa, E20G in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methanol dehydrogenase transcriptional regulatory protein 3481747 moxR3 7561304 moxR3 Mycobacterium bovis BCG str. Tokyo 172 methanol dehydrogenase transcriptional regulatory protein YP_002646229.1 3480785 R 561275 CDS YP_002646230.1 224991541 7563549 complement(3481755..3482237) 1 NC_012207.1 hypothetical protein 3482237 7563549 JTY_3184 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646230.1 3481755 R 561275 CDS YP_002646231.1 224991542 7561305 complement(3482234..3483193) 1 NC_012207.1 Differs from Rv3166c and Mb3191c by 1aa, A202S in BCG Pasteur and BCG Tokyo; hypothetical protein 3483193 7561305 JTY_3185 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646231.1 3482234 R 561275 CDS YP_002646232.1 224991543 7561306 complement(3483273..3483899) 1 NC_012207.1 probably TetR-family; transcriptional regulatory protein 3483899 7561306 JTY_3186 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646232.1 3483273 R 561275 CDS YP_002646233.1 224991544 7561307 3483944..3485080 1 NC_012207.1 Differs from Mb3193 by 1aa, W65R in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3485080 7561307 JTY_3187 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646233.1 3483944 D 561275 CDS YP_002646234.1 224991545 7561308 3485080..3486204 1 NC_012207.1 hypothetical protein 3486204 7561308 JTY_3188 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646234.1 3485080 D 561275 CDS YP_002646235.1 224991546 7561309 3486347..3487693 1 NC_012207.1 flavin-containing monoamine oxidase 3487693 aofH 7561309 aofH Mycobacterium bovis BCG str. Tokyo 172 flavin-containing monoamine oxidase YP_002646235.1 3486347 D 561275 CDS YP_002646236.1 224991547 7563979 complement(3487688..3488587) 1 NC_012207.1 Differs from Rv3171c by 1aa, M201T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; non-heme haloperoxidase 3488587 hpx 7563979 hpx Mycobacterium bovis BCG str. Tokyo 172 non-heme haloperoxidase YP_002646236.1 3487688 R 561275 CDS YP_002646237.1 224991548 7563323 complement(3488724..3489206) 1 NC_012207.1 hypothetical protein 3489206 7563323 JTY_3191 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646237.1 3488724 R 561275 CDS YP_002646238.1 224991549 7561310 complement(3489285..3489887) 1 NC_012207.1 probably TetR/AcrR-family; transcriptional regulatory protein 3489887 7561310 JTY_3192 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646238.1 3489285 R 561275 CDS YP_002646239.1 224991550 7561311 3489980..3490687 1 NC_012207.1 Differs from Rv3174 by 1aa, A9V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; short chain dehydrogenase 3490687 7561311 JTY_3193 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002646239.1 3489980 D 561275 CDS YP_002646240.1 224991551 7561312 3490702..3492189 1 NC_012207.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 3492189 7561312 JTY_3194 Mycobacterium bovis BCG str. Tokyo 172 amidase YP_002646240.1 3490702 D 561275 CDS YP_002646241.1 224991552 7561313 complement(3492186..3492503) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo and Mycobacterium bovis, a frameshift due to a single base deletion (C-*) splits mesT into 2 parts, mesTa and mesTb.; epoxide hydrolase 3492503 mesTb 7561313 mesTb Mycobacterium bovis BCG str. Tokyo 172 epoxide hydrolase YP_002646241.1 3492186 R 561275 CDS YP_002646242.1 224991553 7564457 complement(3492515..3493141) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (C-*) splits mesT into 2 parts, mesTa and mesTb; epoxide hydrolase 3493141 mesTa 7564457 mesTa Mycobacterium bovis BCG str. Tokyo 172 epoxide hydrolase YP_002646242.1 3492515 R 561275 CDS YP_002646243.1 224991554 7564456 3493288..3494148 1 NC_012207.1 non-haem peroxidase; peroxidase 3494148 7564456 JTY_3197 Mycobacterium bovis BCG str. Tokyo 172 peroxidase YP_002646243.1 3493288 D 561275 CDS YP_002646244.1 224991555 7561314 3494279..3494638 1 NC_012207.1 hypothetical protein 3494638 7561314 JTY_3198 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646244.1 3494279 D 561275 CDS YP_002646245.1 224991556 7561315 3494878..3495171 1 NC_012207.1 hypothetical alanine rich protein 3495171 7561315 JTY_3199 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine rich protein YP_002646245.1 3494878 D 561275 CDS YP_002646246.1 224991557 7561316 3495459..3496748 1 NC_012207.1 hypothetical protein 3496748 7561316 JTY_3200 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646246.1 3495459 D 561275 CDS YP_002646247.1 224991558 7561317 complement(3497095..3497529) 1 NC_012207.1 hypothetical alanine rich protein 3497529 7561317 JTY_3201 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine rich protein YP_002646247.1 3497095 R 561275 CDS YP_002646248.1 224991559 7561318 complement(3497532..3497984) 1 NC_012207.1 hypothetical protein 3497984 7561318 JTY_3202 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646248.1 3497532 R 561275 CDS YP_002646249.1 224991560 7561319 3498215..3498559 1 NC_012207.1 hypothetical protein 3498559 7561319 JTY_3203 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646249.1 3498215 D 561275 CDS YP_002646250.1 224991561 7561320 3498556..3498885 1 NC_012207.1 transcriptional regulatory protein 3498885 7561320 JTY_3204 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646250.1 3498556 D 561275 CDS YP_002646251.1 224991562 7561321 3499423..3499770 1 NC_012207.1 hypothetical protein 3499770 7561321 JTY_3205 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646251.1 3499423 D 561275 CDS YP_002646252.1 224991563 7561322 3499767..3500387 1 NC_012207.1 hypothetical protein 3500387 7561322 JTY_3206 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646252.1 3499767 D 561275 CDS YP_002646253.1 224991564 7561323 complement(3500547..3501812) 1 NC_012207.1 Differs from Rv3190c by 2aa, P138L, A330V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3501812 7561323 JTY_3207 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646253.1 3500547 R 561275 CDS YP_002646254.1 224991565 7561324 complement(3502436..3503470) 1 NC_012207.1 transposase 3503470 7561324 JTY_3208 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646254.1 3502436 R 561275 CDS YP_002646255.1 224991566 7564465 3504685..3505146 1 NC_012207.1 hypothetical alanine and proline-rich protein 3505146 7564465 JTY_3209 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine and proline-rich protein YP_002646255.1 3504685 D 561275 CDS YP_002646256.1 224991567 7561326 complement(3505316..3508294) 1 NC_012207.1 Differs from Rv3193c by 2aa, E356Q, Q843R, and from Mb3215c by 1aa, E356Q in BCG Pasteur and BCG Tokyo; hypothetical protein 3508294 7561326 JTY_3210 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646256.1 3505316 R 561275 CDS YP_002646257.1 224991568 7561327 complement(3508386..3509408) 1 NC_012207.1 hypothetical protein 3509408 7561327 JTY_3211 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646257.1 3508386 R 561275 CDS YP_002646258.1 224991569 7561328 3509486..3510904 1 NC_012207.1 hypothetical protein 3510904 7561328 JTY_3212 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646258.1 3509486 D 561275 CDS YP_002646259.1 224991570 7561329 3510910..3511809 1 NC_012207.1 hypothetical protein 3511809 7561329 JTY_3213 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646259.1 3510910 D 561275 CDS YP_002646260.1 224991571 7561330 complement(3511818..3512018) 1 NC_012207.1 hypothetical protein 3512018 7561330 JTY_3214 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646260.1 3511818 R 561275 CDS YP_002646261.1 224991572 7561331 3512156..3513499 1 NC_012207.1 ATP-binding protein ABC transporter 3513499 7561331 JTY_3215 Mycobacterium bovis BCG str. Tokyo 172 ATP-binding protein ABC transporter YP_002646261.1 3512156 D 561275 CDS YP_002646262.1 224991573 7561332 complement(3513533..3513811) 1 NC_012207.1 transcriptional regulatory protein whiB-like 3513811 whiB7 7561332 whiB7 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein whiB-like YP_002646262.1 3513533 R 561275 CDS YP_002646263.1 224991574 7561695 complement(3514241..3516343) 1 NC_012207.1 DNA helicase II homolog 3516343 UvrD2 7561695 UvrD2 Mycobacterium bovis BCG str. Tokyo 172 DNA helicase II homolog YP_002646263.1 3514241 R 561275 CDS YP_002646264.1 224991575 7561676 3516467..3516721 1 NC_012207.1 glutaredoxin protein 3516721 7561676 JTY_3218 Mycobacterium bovis BCG str. Tokyo 172 glutaredoxin protein YP_002646264.1 3516467 D 561275 CDS YP_002646265.1 224991576 7561333 complement(3516734..3517675) 1 NC_012207.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 3517675 nudC 7561333 nudC Mycobacterium bovis BCG str. Tokyo 172 NADH pyrophosphatase YP_002646265.1 3516734 R 561275 CDS YP_002646266.1 224991577 7562473 complement(3517734..3518801) 1 NC_012207.1 Differs from Rv3200c by 1aa, D12N in Mycobacterium bovis , Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane cation transporter 3518801 7562473 JTY_3220 Mycobacterium bovis BCG str. Tokyo 172 transmembrane cation transporter YP_002646266.1 3517734 R 561275 CDS YP_002646267.1 224991578 7561334 complement(3518863..3522168) 1 NC_012207.1 ATP-dependent DNA helicase 3522168 7561334 JTY_3221 Mycobacterium bovis BCG str. Tokyo 172 ATP-dependent DNA helicase YP_002646267.1 3518863 R 561275 CDS YP_002646268.1 224991579 7561335 complement(3522165..3525332) 1 NC_012207.1 Differs from Rv3202c by 1aa, A748V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; ATP-dependent DNA helicase 3525332 7561335 JTY_3222 Mycobacterium bovis BCG str. Tokyo 172 ATP-dependent DNA helicase YP_002646268.1 3522165 R 561275 CDS YP_002646269.1 224991580 7561336 3525409..3525627 1 NC_012207.1 hypothetical protein 3525627 7561336 JTY_3223 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646269.1 3525409 D 561275 CDS YP_002646270.1 224991581 7561337 3525769..3526443 1 NC_012207.1 lipase 3526443 lipV 7561337 lipV Mycobacterium bovis BCG str. Tokyo 172 lipase YP_002646270.1 3525769 D 561275 CDS YP_002646271.1 224991582 7562848 3526446..3526751 1 NC_012207.1 Differs from Rv3204 by 1aa, A34T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; DNA-methyltransferase 3526751 7562848 JTY_3225 Mycobacterium bovis BCG str. Tokyo 172 DNA-methyltransferase YP_002646271.1 3526446 D 561275 CDS YP_002646272.1 224991583 7561338 complement(3526758..3527636) 1 NC_012207.1 hypothetical protein 3527636 7561338 JTY_3226 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646272.1 3526758 R 561275 CDS YP_002646273.1 224991584 7561339 complement(3527663..3528841) 1 NC_012207.1 The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; molybdopterin biosynthesis-like protein MoeZ 3528841 moeB1 7561339 moeB1 Mycobacterium bovis BCG str. Tokyo 172 molybdopterin biosynthesis-like protein MoeZ YP_002646273.1 3527663 R 561275 CDS YP_002646274.1 224991585 7563541 complement(3528932..3529789) 1 NC_012207.1 Differs from Rv3207c by 1aa, N157D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3529789 7563541 JTY_3228 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646274.1 3528932 R 561275 CDS YP_002646275.1 224991586 7561340 3530135..3530821 1 NC_012207.1 probably TetR-family; transcriptional regulatory protein 3530821 7561340 JTY_3229 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646275.1 3530135 D 561275 CDS YP_002646276.1 224991587 7561341 complement(3530808..3531080) 1 NC_012207.1 hypothetical protein 3531080 TB9.4 7561341 TB9.4 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646276.1 3530808 R 561275 CDS YP_002646277.1 224991588 7561837 3531405..3531965 1 NC_012207.1 hypothetical threonine and proline rich protein 3531965 7561837 JTY_3231 Mycobacterium bovis BCG str. Tokyo 172 hypothetical threonine and proline rich protein YP_002646277.1 3531405 D 561275 CDS YP_002646278.1 224991589 7561342 complement(3531975..3532670) 1 NC_012207.1 hypothetical protein 3532670 7561342 JTY_3232 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646278.1 3531975 R 561275 CDS YP_002646279.1 224991590 7561343 3532929..3534512 1 NC_012207.1 Differs from Mb3237 by 1aa, V17A in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; ATP-dependent RNA helicase 3534512 rhlE 7561343 rhlE Mycobacterium bovis BCG str. Tokyo 172 ATP-dependent RNA helicase YP_002646279.1 3532929 D 561275 CDS YP_002646280.1 224991591 7561569 3534525..3535748 1 NC_012207.1 Differs from Mb3238 by 1aa, G225D, and from Rv3212 by 2aa, G225D, A250V in BCG Pasteur and BCG Tokyo; hypothetical alanine valine rich protein 3535748 7561569 JTY_3234 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine valine rich protein YP_002646280.1 3534525 D 561275 CDS YP_002646281.1 224991592 7561344 complement(3535824..3536624) 1 NC_012207.1 Differs from Rv3213c by 1aa, E144K in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; soj/ParA-related protein 3536624 7561344 JTY_3235 Mycobacterium bovis BCG str. Tokyo 172 soj/ParA-related protein YP_002646281.1 3535824 R 561275 CDS YP_002646282.1 224991593 7561345 3536778..3537389 1 NC_012207.1 forms a homodimer in Mycobacterium tuberculosis; belongs to the dPGM superfamily; acid phosphatase 3537389 gpm2_1 7561345 gpm2_1 Mycobacterium bovis BCG str. Tokyo 172 acid phosphatase YP_002646282.1 3536778 D 561275 CDS YP_002646283.1 224991594 7563276 3537386..3538504 1 NC_012207.1 isochorismate synthase 3538504 entC_1 7563276 entC_1 Mycobacterium bovis BCG str. Tokyo 172 isochorismate synthase YP_002646283.1 3537386 D 561275 CDS YP_002646284.1 224991595 7562866 3538652..3538984 1 NC_012207.1 acetyltransferase 3538984 7562866 JTY_3238 Mycobacterium bovis BCG str. Tokyo 172 acetyltransferase YP_002646284.1 3538652 D 561275 CDS YP_002646285.1 224991596 7561346 complement(3538936..3539367) 1 NC_012207.1 integral membrane protein 3539367 7561346 JTY_3239 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002646285.1 3538936 R 561275 CDS YP_002646286.1 224991597 7561347 3539600..3540565 1 NC_012207.1 hypothetical protein 3540565 7561347 JTY_3240 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646286.1 3539600 D 561275 CDS YP_002646287.1 224991598 7561348 3540845..3541099 1 NC_012207.1 transcriptional regulatory protein whiB-like 3541099 whiB1_1 7561348 whiB1_1 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein whiB-like YP_002646287.1 3540845 D 561275 CDS YP_002646288.1 224991599 7561689 complement(3541161..3542666) 1 NC_012207.1 Differs from Rv3220c by 1aa, N47D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; two component sensor kinase 3542666 7561689 JTY_3242 Mycobacterium bovis BCG str. Tokyo 172 two component sensor kinase YP_002646288.1 3541161 R 561275 CDS YP_002646289.1 224991600 7561349 complement(3542683..3542898) 1 NC_012207.1 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3542898 TB7.3_1 7561349 TB7.3_1 Mycobacterium bovis BCG str. Tokyo 172 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_002646289.1 3542683 R 561275 CDS YP_002646290.1 224991601 7561836 complement(3543183..3543488) 1 NC_012207.1 anti-sigma factor 3543488 7561836 JTY_3244 Mycobacterium bovis BCG str. Tokyo 172 anti-sigma factor YP_002646290.1 3543183 R 561275 CDS YP_002646291.1 224991602 7561350 complement(3543485..3544036) 1 NC_012207.1 hypothetical protein 3544036 7561350 JTY_3245 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646291.1 3543485 R 561275 CDS YP_002646292.1 224991603 7561351 complement(3544033..3544683) 1 NC_012207.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 3544683 sigH_1 7561351 sigH_1 Mycobacterium bovis BCG str. Tokyo 172 RNA polymerase sigma factor RpoE YP_002646292.1 3544033 R 561275 CDS YP_002646293.1 224991604 7561792 3544983..3545831 1 NC_012207.1 short chain dehydrogenase 3545831 7561792 JTY_3247 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002646293.1 3544983 D 561275 CDS YP_002646294.1 224991605 7561352 3545767..3545955 1 NC_012207.1 hypothetical protein 3545955 7561352 JTY_3248 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646294.1 3545767 D 561275 CDS YP_002646295.1 224991606 7561353 3545933..3546151 1 NC_012207.1 hypothetical protein 3546151 7561353 JTY_3249 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646295.1 3545933 D 561275 CDS YP_002646296.1 224991607 7561354 complement(3546148..3547572) 1 NC_012207.1 Differs from Rv3225c by 1aa T306A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transferase 3547572 7561354 JTY_3250 Mycobacterium bovis BCG str. Tokyo 172 transferase YP_002646296.1 3546148 R 561275 CDS YP_002646297.1 224991608 7561355 complement(3547696..3548454) 1 NC_012207.1 hypothetical protein 3548454 7561355 JTY_3251 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646297.1 3547696 R 561275 CDS YP_002646298.1 224991609 7561356 3548509..3549861 1 NC_012207.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 3549861 aroA_1 7561356 aroA_1 Mycobacterium bovis BCG str. Tokyo 172 3-phosphoshikimate 1-carboxyvinyltransferase YP_002646298.1 3548509 D 561275 CDS YP_002646299.1 224991610 7563996 3549858..3550850 1 NC_012207.1 Differs from Rv3228, Mb3257 and BCG_3351 by 1aa, D169G in Mycobacterium bovis BCG Pasteur.; hypothetical protein 3550850 7563996 JTY_3253 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646299.1 3549858 D 561275 CDS YP_002646300.1 224991611 7561357 complement(3550883..3552166) 1 NC_012207.1 linoleoyl-CoA desaturase 3552166 desA3_1 7561357 desA3_1 Mycobacterium bovis BCG str. Tokyo 172 linoleoyl-CoA desaturase YP_002646300.1 3550883 R 561275 CDS YP_002646301.1 224991612 7561485 complement(3552244..3553386) 1 NC_012207.1 Differs from Rv3230c by 1aa, C105R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 3553386 7561485 JTY_3255 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646301.1 3552244 R 561275 CDS YP_002646302.1 224991613 7561358 complement(3553496..3554005) 1 NC_012207.1 In DU2 of BCG Pasteur, the second copy (BCG_3354c) is truncated.; hypothetical protein 3554005 7561358 JTY_3256 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646302.1 3553496 R 561275 CDS YP_002646303.1 224991614 7561359 complement(3554002..3554889) 1 NC_012207.1 transcriptional regulatory protein 3554889 pvdS 7561359 pvdS Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646303.1 3554002 R 561275 CDS YP_002646304.1 224991615 7560868 complement(3554913..3555332) 1 NC_012207.1 In Mycobacterium tuberculosis H37Rv, Rv3234c and Rv3233c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis (Mb3262c), a single base insertion (*-G) leads to a single product that is more similar to Rv3234c. In Mycobacterium BCG Tokyo, two bases insertion, (*-G) and (*-T) leads to two products that is more similar to Rv3234c.; hypothetical protein 3555332 7560868 JTY_3258 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646304.1 3554913 R 561275 CDS YP_002646305.1 224991616 7561360 complement(3555340..3556323) 1 NC_012207.1 In Mycobacterium tuberculosis H37Rv, Rv3234c and Rv3233c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-G) leads to a single product that is more similar to Rv3234c. In Mycobacterium BCG Tokyo, two bases insertion, (*-g) and (*-T) leads to two products that is more similar to Rv3234c.; hypothetical protein 3556323 7561360 JTY_3259 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646305.1 3555340 R 561275 CDS YP_002646306.1 224991617 7561361 3556434..3557075 1 NC_012207.1 hypothetical alanine arginine proline rich protein 3557075 7561361 JTY_3260 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine arginine proline rich protein YP_002646306.1 3556434 D 561275 CDS YP_002646307.1 224991618 7561362 complement(3557093..3558250) 1 NC_012207.1 integral membrane transport protein 3558250 7561362 JTY_3261 Mycobacterium bovis BCG str. Tokyo 172 integral membrane transport protein YP_002646307.1 3557093 R 561275 CDS YP_002646308.1 224991619 7561363 complement(3558255..3558737) 1 NC_012207.1 hypothetical protein 3558737 7561363 JTY_3262 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646308.1 3558255 R 561275 CDS YP_002646309.1 224991620 7561364 complement(3558798..3559532) 1 NC_012207.1 integral membrane protein 3559532 7561364 JTY_3263 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002646309.1 3558798 R 561275 CDS YP_002646310.1 224991621 7561365 complement(3559591..3562737) 1 NC_012207.1 Differs from Mb3267c by 1aa, R867H in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane transport protein 3562737 7561365 JTY_3264 Mycobacterium bovis BCG str. Tokyo 172 transmembrane transport protein YP_002646310.1 3559591 R 561275 CDS YP_002646311.1 224991622 7561366 complement(3562816..3565665) 1 NC_012207.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 3565665 secA1 7561366 secA1 Mycobacterium bovis BCG str. Tokyo 172 preprotein translocase subunit SecA YP_002646311.1 3562816 R 561275 CDS YP_002646312.1 224991623 7560770 complement(3565744..3566388) 1 NC_012207.1 hypothetical protein 3566388 7560770 JTY_3266 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646312.1 3565744 R 561275 CDS YP_002646313.1 224991624 7561367 complement(3566704..3567345) 1 NC_012207.1 Differs from Rv3242c and Mb3270c by 1aa, S89L in Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 3567345 7561367 JTY_3267 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646313.1 3566704 R 561275 CDS YP_002646314.1 224991625 7560876 complement(3567383..3568225) 1 NC_012207.1 hypothetical protein 3568225 7560876 JTY_3268 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646314.1 3567383 R 561275 CDS YP_002646315.1 224991626 7560877 complement(3568293..3570044) 1 NC_012207.1 Differs from Rv3244c by 2aa, G142D, L394S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein LpqB 3570044 lpqB 7560877 lpqB Mycobacterium bovis BCG str. Tokyo 172 lipoprotein LpqB YP_002646315.1 3568293 R 561275 CDS YP_002646316.1 224991627 7560494 complement(3570044..3571747) 1 NC_012207.1 Differs from Rv3245c by 1aa, L517M in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; two component sensory transduction histidine kinase 3571747 mtrB 7560494 mtrB Mycobacterium bovis BCG str. Tokyo 172 two component sensory transduction histidine kinase YP_002646316.1 3570044 R 561275 CDS YP_002646317.1 224991628 7563570 complement(3571797..3572483) 1 NC_012207.1 two component sensory transduction transcriptional regulatory protein 3572483 mtrA 7563570 mtrA Mycobacterium bovis BCG str. Tokyo 172 two component sensory transduction transcriptional regulatory protein YP_002646317.1 3571797 R 561275 CDS YP_002646318.1 224991629 7563569 complement(3572553..3573197) 1 NC_012207.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 3573197 tmk 7563569 tmk Mycobacterium bovis BCG str. Tokyo 172 thymidylate kinase YP_002646318.1 3572553 R 561275 CDS YP_002646319.1 224991630 7561862 complement(3573294..3574781) 1 NC_012207.1 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase 3574781 sahH 7561862 sahH Mycobacterium bovis BCG str. Tokyo 172 S-adenosyl-L-homocysteine hydrolase YP_002646319.1 3573294 R 561275 CDS YP_002646320.1 224991631 7560754 complement(3574886..3575521) 1 NC_012207.1 probably TetR-family; transcriptional regulatory protein 3575521 7560754 JTY_3274 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646320.1 3574886 R 561275 CDS YP_002646321.1 224991632 7560878 complement(3575518..3575700) 1 NC_012207.1 rubredoxin RubB 3575700 7560878 JTY_3275 Mycobacterium bovis BCG str. Tokyo 172 rubredoxin RubB YP_002646321.1 3575518 R 561275 CDS YP_002646322.1 224991633 7560879 complement(3575705..3575872) 1 NC_012207.1 rubredoxin RubA 3575872 7560879 JTY_3276 Mycobacterium bovis BCG str. Tokyo 172 rubredoxin RubA YP_002646322.1 3575705 R 561275 CDS YP_002646323.1 224991634 7560880 complement(3575872..3577122) 1 NC_012207.1 transmembrane alkane 1-monooxygenase 3577122 alkB 7560880 alkB Mycobacterium bovis BCG str. Tokyo 172 transmembrane alkane 1-monooxygenase YP_002646323.1 3575872 R 561275 CDS YP_002646324.1 224991635 7563963 complement(3577231..3578718) 1 NC_012207.1 cationic amino acid transport integral membrane protein 3578718 7563963 JTY_3278 Mycobacterium bovis BCG str. Tokyo 172 cationic amino acid transport integral membrane protein YP_002646324.1 3577231 R 561275 CDS YP_002646325.1 224991636 7560881 3578809..3580197 1 NC_012207.1 hypothetical protein 3580197 7560881 JTY_3279 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646325.1 3578809 D 561275 CDS YP_002646326.1 224991637 7560882 complement(3580175..3581401) 1 NC_012207.1 mannose-6-phosphate isomerase 3581401 manA 7560882 manA Mycobacterium bovis BCG str. Tokyo 172 mannose-6-phosphate isomerase YP_002646326.1 3580175 R 561275 CDS YP_002646327.1 224991638 7564415 complement(3581409..3582449) 1 NC_012207.1 hypothetical protein 3582449 7564415 JTY_3281 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646327.1 3581409 R 561275 CDS YP_002646328.1 224991639 7560883 complement(3582446..3583843) 1 NC_012207.1 converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells; phosphomannomutase/phosphoglucomutase 3583843 manB 7560883 manB Mycobacterium bovis BCG str. Tokyo 172 phosphomannomutase/phosphoglucomutase YP_002646328.1 3582446 R 561275 CDS YP_002646329.1 224991640 7564416 complement(3583945..3584436) 1 NC_012207.1 hypothetical protein 3584436 7564416 JTY_3283 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646329.1 3583945 R 561275 CDS YP_002646330.1 224991641 7560884 3584559..3584978 1 NC_012207.1 hypothetical protein 3584978 7560884 JTY_3284 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646330.1 3584559 D 561275 CDS YP_002646331.1 224991642 7560885 complement(3585006..3585275) 1 NC_012207.1 transcriptional regulatory protein WhiB-like 3585275 whiB2 7560885 whiB2 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein WhiB-like YP_002646331.1 3585006 R 561275 CDS YP_002646332.1 224991643 7561690 3585677..3586672 1 NC_012207.1 catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); LPPG:FO 2-phospho-L-lactate transferase 3586672 fbiA 7561690 fbiA Mycobacterium bovis BCG str. Tokyo 172 LPPG:FO 2-phospho-L-lactate transferase YP_002646332.1 3585677 D 561275 CDS YP_002646333.1 224991644 7563397 3586669..3588015 1 NC_012207.1 catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0); F420-0--gamma-glutamyl ligase 3588015 fbiB 7563397 fbiB Mycobacterium bovis BCG str. Tokyo 172 F420-0--gamma-glutamyl ligase YP_002646333.1 3586669 D 561275 CDS YP_002646334.1 224991645 7563398 3588311..3589972 1 NC_012207.1 DNA methylase 3589972 7563398 JTY_3288 Mycobacterium bovis BCG str. Tokyo 172 DNA methylase YP_002646334.1 3588311 D 561275 CDS YP_002646335.1 224991646 7560886 complement(3590032..3591111) 1 NC_012207.1 mannose-1-phosphate guanyltransferase 3591111 manC 7560886 manC Mycobacterium bovis BCG str. Tokyo 172 mannose-1-phosphate guanyltransferase YP_002646335.1 3590032 R 561275 CDS YP_002646336.1 224991647 7564417 complement(3591113..3592006) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, an in-frame deletion of 12 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (297 aa versus 301aa); dTDP-RHA:A-D-GlcNAc-diphosphoryl polyprenol, A-3-L-rhamnosyl transferase 3592006 wbbL1 7564417 wbbL1 Mycobacterium bovis BCG str. Tokyo 172 dTDP-RHA:A-D-GlcNAc-diphosphoryl polyprenol, A-3-L-rhamnosyl transferase YP_002646336.1 3591113 R 561275 CDS YP_002646337.1 224991648 7561686 complement(3592017..3592931) 1 NC_012207.1 Differs from Rv3266c by 1aa, P257S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; dTDP-rhamnose modification protein 3592931 rmld 7561686 rmld Mycobacterium bovis BCG str. Tokyo 172 dTDP-rhamnose modification protein YP_002646337.1 3592017 R 561275 CDS YP_002646338.1 224991649 7561585 3593007..3594503 1 NC_012207.1 hypothetical protein 3594503 7561585 JTY_3292 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646338.1 3593007 D 561275 CDS YP_002646339.1 224991650 7560887 3594542..3595231 1 NC_012207.1 hypothetical protein 3595231 7560887 JTY_3293 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646339.1 3594542 D 561275 CDS YP_002646340.1 224991651 7560888 3595356..3595637 1 NC_012207.1 hypothetical protein 3595637 7560888 JTY_3294 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646340.1 3595356 D 561275 CDS YP_002646341.1 224991652 7560889 3595648..3597804 1 NC_012207.1 metal cation-transporting P-type ATPase C 3597804 ctpC 7560889 ctpC Mycobacterium bovis BCG str. Tokyo 172 metal cation-transporting P-type ATPase C YP_002646341.1 3595648 D 561275 CDS YP_002646342.1 224991653 7563133 complement(3597801..3598469) 1 NC_012207.1 integral membrane protein 3598469 7563133 JTY_3296 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002646342.1 3597801 R 561275 CDS YP_002646343.1 224991654 7560890 3598570..3599754 1 NC_012207.1 Differs from Mb3300 by 1aa, R259G, and from Rv3272 by 2aa, R259G, S347N in BCG Pasteur and BCG Tokyo; hypothetical protein 3599754 7560890 JTY_3297 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646343.1 3598570 D 561275 CDS YP_002646344.1 224991655 7560891 3599759..3602053 1 NC_012207.1 transmembrane carbonic anhydrase 3602053 7560891 JTY_3298 Mycobacterium bovis BCG str. Tokyo 172 transmembrane carbonic anhydrase YP_002646344.1 3599759 D 561275 CDS YP_002646345.1 224991656 7560892 complement(3602042..3603211) 1 NC_012207.1 acyl-CoA dehydrogenase 3603211 fadE25 7560892 fadE25 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002646345.1 3602042 R 561275 CDS YP_002646346.1 224991657 7563374 complement(3603236..3603760) 1 NC_012207.1 Differs from Rv3275c by 1aa, R125G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; phosphoribosylaminoimidazole carboxylase catalytic subunit 3603760 purE 7563374 purE Mycobacterium bovis BCG str. Tokyo 172 phosphoribosylaminoimidazole carboxylase catalytic subunit YP_002646346.1 3603236 R 561275 CDS YP_002646347.1 224991658 7560858 complement(3603757..3605046) 1 NC_012207.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 3605046 purK 7560858 purK Mycobacterium bovis BCG str. Tokyo 172 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_002646347.1 3603757 R 561275 CDS YP_002646348.1 224991659 7560861 3605000..3605818 1 NC_012207.1 Differs from Rv3277 by 1 aa, L272S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 3605818 7560861 JTY_3302 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646348.1 3605000 D 561275 CDS YP_002646349.1 224991660 7560893 complement(3605773..3606291) 1 NC_012207.1 Differs from Rv3278c by 1aa, K160E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur. Differs from Rv3278c by 2aa, T54I, K160E in Mycobacterium bovis BCG Tokyo.; transmembrane protein 3606291 7560893 JTY_3303 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646349.1 3605773 R 561275 CDS YP_002646350.1 224991661 7560894 complement(3606334..3607134) 1 NC_012207.1 Differs from Rv3279c by 1aa, N211D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; biotin--[acetyl-CoA-carboxylase] synthetase; biotin operon repressor 3607134 birA 7560894 birA Mycobacterium bovis BCG str. Tokyo 172 biotin operon repressor YP_002646350.1 3606334 R 561275 CDS YP_002646351.1 224991662 7562071 3607184..3608830 1 NC_012207.1 Differs from Rv3280 by 1aa, A448V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; propionyl-CoA carboxylase beta chain 5 3608830 accD5 7562071 accD5 Mycobacterium bovis BCG str. Tokyo 172 propionyl-CoA carboxylase beta chain 5 YP_002646351.1 3607184 D 561275 CDS YP_002646352.1 224991663 7563925 3608811..3609281 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, an in-frame deletion of 63 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (156 aa versus 177aa). Loss of tandem repeat SRVSGTNEVSDGNETNNPAPV; hypothetical protein 3609281 7563925 JTY_3306 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646352.1 3608811 D 561275 CDS YP_002646353.1 224991664 7560895 3609278..3609946 1 NC_012207.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 3609946 7560895 JTY_3307 Mycobacterium bovis BCG str. Tokyo 172 Maf-like protein YP_002646353.1 3609278 D 561275 CDS YP_002646354.1 224991665 7560896 3609987..3610880 1 NC_012207.1 Differs from Mb3311 by 1aa, G170D in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; thiosulfate sulfurtransferase 3610880 sseA 7560896 sseA Mycobacterium bovis BCG str. Tokyo 172 thiosulfate sulfurtransferase YP_002646354.1 3609987 D 561275 CDS YP_002646355.1 224991666 7561808 3610877..3611308 1 NC_012207.1 hypothetical protein 3611308 7561808 JTY_3309 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646355.1 3610877 D 561275 CDS YP_002646356.1 224991667 7560897 3611416..3613218 1 NC_012207.1 biotin carboxylase, biotin carboxyl carrier protein, accA3; acetyl-/propionyl-coenzyme A carboxylase alpha chain 3613218 accA3 7560897 accA3 Mycobacterium bovis BCG str. Tokyo 172 acetyl-/propionyl-coenzyme A carboxylase alpha chain YP_002646356.1 3611416 D 561275 CDS YP_002646357.1 224991668 7564331 complement(3613228..3614013) 1 NC_012207.1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is a general stress response regulator; expressed in stationary phase and under nitrogen depletion and cold shock; RNA polymerase sigma factor SigF 3614013 sigF 7564331 sigF Mycobacterium bovis BCG str. Tokyo 172 RNA polymerase sigma factor SigF YP_002646357.1 3613228 R 561275 CDS YP_002646358.1 224991669 7561790 complement(3614010..3614447) 1 NC_012207.1 anti-sigma factor 3614447 rsbW 7561790 rsbW Mycobacterium bovis BCG str. Tokyo 172 anti-sigma factor YP_002646358.1 3614010 R 561275 CDS YP_002646359.1 224991670 7560750 complement(3614645..3615058) 1 NC_012207.1 hypothetical protein 3615058 usfY 7560750 usfY Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646359.1 3614645 R 561275 CDS YP_002646360.1 224991671 7561668 complement(3615093..3615470) 1 NC_012207.1 transmembrane protein 3615470 7561668 JTY_3314 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646360.1 3615093 R 561275 CDS YP_002646361.1 224991672 7560898 complement(3615504..3616853) 1 NC_012207.1 catalyzes the formation of 2-aminoadipate 6-semiladehyde and glutamate from lysine and 2-oxoglutarate; L-lysine aminotransferase 3616853 lat 7560898 lat Mycobacterium bovis BCG str. Tokyo 172 L-lysine aminotransferase YP_002646361.1 3615504 R 561275 CDS YP_002646362.1 224991673 7562810 complement(3616904..3617356) 1 NC_012207.1 Differs from Rv3291c by 1aa, V22A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably AsnC-family; transcriptional regulatory protein 3617356 7562810 JTY_3316 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646362.1 3616904 R 561275 CDS YP_002646363.1 224991674 7560899 3617387..3618634 1 NC_012207.1 hypothetical protein 3618634 7560899 JTY_3317 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646363.1 3617387 D 561275 CDS YP_002646364.1 224991675 7560900 3618661..3620145 1 NC_012207.1 Differs from Rv3293 by 1aa, C273G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; piperideine-6-carboxilic acid dehydrogenase 3620145 pcd 7560900 pcd Mycobacterium bovis BCG str. Tokyo 172 piperideine-6-carboxilic acid dehydrogenase YP_002646364.1 3618661 D 561275 CDS YP_002646365.1 224991676 7562522 complement(3620245..3621054) 1 NC_012207.1 hypothetical protein 3621054 7562522 JTY_3319 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646365.1 3620245 R 561275 CDS YP_002646366.1 224991677 7560901 3621125..3621790 1 NC_012207.1 probably TetR-family; transcriptional regulatory protein 3621790 7560901 JTY_3320 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646366.1 3621125 D 561275 CDS YP_002646367.1 224991678 7560902 3621834..3626375 1 NC_012207.1 Differs from Rv3296 by 3aa, M719V, N818D, E1059K in Mycobacterium bovis and Mycobacterium bovis BCG Pasteur. Differs from Rv3296 by 4aa, T719V, M796L, N818D, E1059K in Mycobacterium bovis BCG Tokyo.; ATP-dependent helicase 3626375 lhr 7560902 lhr Mycobacterium bovis BCG str. Tokyo 172 ATP-dependent helicase YP_002646367.1 3621834 D 561275 CDS YP_002646368.1 224991679 7562825 3626379..3627146 1 NC_012207.1 endonuclease VIII 3627146 nei_1 7562825 nei_1 Mycobacterium bovis BCG str. Tokyo 172 endonuclease VIII YP_002646368.1 3626379 D 561275 CDS YP_002646369.1 224991680 7562459 complement(3627169..3628083) 1 NC_012207.1 esterase lipoprotein 3628083 lpqC 7562459 lpqC Mycobacterium bovis BCG str. Tokyo 172 esterase lipoprotein YP_002646369.1 3627169 R 561275 CDS YP_002646370.1 224991681 7560495 complement(3628110..3631022) 1 NC_012207.1 Differs from Rv3299c by 1aa, S204G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; arylsulfatase 3631022 atsB_1 7560495 atsB_1 Mycobacterium bovis BCG str. Tokyo 172 arylsulfatase YP_002646370.1 3628110 R 561275 CDS YP_002646371.1 224991682 7562056 complement(3631042..3631959) 1 NC_012207.1 Differs from Mb3328c by 1aa, D52N in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3631959 7562056 JTY_3325 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646371.1 3631042 R 561275 CDS YP_002646372.1 224991683 7560903 complement(3631971..3632636) 1 NC_012207.1 Differs from Rv3301c and Mb3329c by 1aa, S74A in BCG Pasteur and BCG Tokyo; phosphate-transport system transcriptional regulatory protein PhoU homolog 1 3632636 phoY1_1 7560903 phoY1_1 Mycobacterium bovis BCG str. Tokyo 172 phosphate-transport system transcriptional regulatory protein PhoU homolog 1 YP_002646372.1 3631971 R 561275 CDS YP_002646373.1 224991684 7562415 complement(3632744..3634501) 1 NC_012207.1 glycerol-3-phosphate dehydrogenase 3634501 glpD2_1 7562415 glpD2_1 Mycobacterium bovis BCG str. Tokyo 172 glycerol-3-phosphate dehydrogenase YP_002646373.1 3632744 R 561275 CDS YP_002646374.1 224991685 7561938 complement(3634582..3635997) 1 NC_012207.1 catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; flavoprotein disulfide reductase 3635997 lpdA_1 7561938 lpdA_1 Mycobacterium bovis BCG str. Tokyo 172 flavoprotein disulfide reductase YP_002646374.1 3634582 R 561275 CDS YP_002646375.1 224991686 7562853 3636200..3636679 1 NC_012207.1 hypothetical protein 3636679 7562853 JTY_3329 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646375.1 3636200 D 561275 CDS YP_002646376.1 224991687 7560904 complement(3636698..3637867) 1 NC_012207.1 N-acyl-L-amino acid amidohydrolase 3637867 amiA1_1 7560904 amiA1_1 Mycobacterium bovis BCG str. Tokyo 172 N-acyl-L-amino acid amidohydrolase YP_002646376.1 3636698 R 561275 CDS YP_002646377.1 224991688 7563965 complement(3637864..3639048) 1 NC_012207.1 amidase 3639048 amiB1_1 7563965 amiB1_1 Mycobacterium bovis BCG str. Tokyo 172 amidase YP_002646377.1 3637864 R 561275 CDS YP_002646378.1 224991689 7563969 3639113..3639919 1 NC_012207.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 3639919 deoD_1 7563969 deoD_1 Mycobacterium bovis BCG str. Tokyo 172 purine nucleoside phosphorylase YP_002646378.1 3639113 D 561275 CDS YP_002646379.1 224991690 7561480 3639923..3641527 1 NC_012207.1 Differs from Rv3308 by 1aa, G440S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; phosphomannomutase 3641527 pmmB_1 7561480 pmmB_1 Mycobacterium bovis BCG str. Tokyo 172 phosphomannomutase YP_002646379.1 3639923 D 561275 CDS YP_002646380.1 224991691 7562131 complement(3641529..3642152) 1 NC_012207.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 3642152 upp 7562131 upp Mycobacterium bovis BCG str. Tokyo 172 uracil phosphoribosyltransferase YP_002646380.1 3641529 R 561275 CDS YP_002646381.1 224991692 7561659 3642257..3643156 1 NC_012207.1 Differs from Rv3310 by 1aa, A171T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acid phosphatase 3643156 sapM_1 7561659 sapM_1 Mycobacterium bovis BCG str. Tokyo 172 acid phosphatase YP_002646381.1 3642257 D 561275 CDS YP_002646382.1 224991693 7560755 3643180..3644442 1 NC_012207.1 hypothetical protein 3644442 7560755 JTY_3336 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646382.1 3643180 D 561275 CDS YP_002646383.1 224991694 7560905 complement(3644463..3645389) 1 NC_012207.1 hypothetical protein 3645389 7560905 JTY_3337 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646383.1 3644463 R 561275 CDS YP_002646384.1 224991695 7560906 complement(3645764..3646075) 1 NC_012207.1 hypothetical protein antigen 3646075 7560906 JTY_3338 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein antigen YP_002646384.1 3645764 R 561275 CDS YP_002646385.1 224991696 7560907 complement(3646146..3647243) 1 NC_012207.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 3647243 add_1 7560907 add_1 Mycobacterium bovis BCG str. Tokyo 172 adenosine deaminase YP_002646385.1 3646146 R 561275 CDS YP_002646386.1 224991697 7563937 complement(3647243..3648526) 1 NC_012207.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 3648526 deoA 7563937 deoA Mycobacterium bovis BCG str. Tokyo 172 thymidine phosphorylase YP_002646386.1 3647243 R 561275 CDS YP_002646387.1 224991698 7561476 complement(3648523..3648924) 1 NC_012207.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 3648924 cdd_1 7561476 cdd_1 Mycobacterium bovis BCG str. Tokyo 172 cytidine deaminase YP_002646387.1 3648523 R 561275 CDS YP_002646388.1 224991699 7562087 3649161..3649499 1 NC_012207.1 cytochrome b-556 subunit; succinate dehydrogenase 3649499 sdhC_1 7562087 sdhC_1 Mycobacterium bovis BCG str. Tokyo 172 succinate dehydrogenase YP_002646388.1 3649161 D 561275 CDS YP_002646389.1 224991700 7560764 3649496..3649930 1 NC_012207.1 Differs from Rv3317 by 1aa, L54V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrophobic membrane anchor subunit; succinate dehydrogenase 3649930 sdhD_1 7560764 sdhD_1 Mycobacterium bovis BCG str. Tokyo 172 succinate dehydrogenase YP_002646389.1 3649496 D 561275 CDS YP_002646390.1 224991701 7562057 complement(3651746..3652663) 1 NC_012207.1 Differs from Mb3328c by 1aa, D52N in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3652663 7562057 JTY_3345 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646390.1 3651746 R 561275 CDS YP_002646391.1 224991702 7560908 complement(3652675..3653340) 1 NC_012207.1 Differs from Rv3301c and Mb3329c by 1aa, S74A in Mycobacterium bovis BCG Pasteur and BCG Tokyo; phosphate-transport system transcriptional regulatory protein PhoU homolog 1 3653340 phoY1_2 7560908 phoY1_2 Mycobacterium bovis BCG str. Tokyo 172 phosphate-transport system transcriptional regulatory protein PhoU homolog 1 YP_002646391.1 3652675 R 561275 CDS YP_002646392.1 224991703 7562416 complement(3653448..3655205) 1 NC_012207.1 glycerol-3-phosphate dehydrogenase 3655205 glpD2_2 7562416 glpD2_2 Mycobacterium bovis BCG str. Tokyo 172 glycerol-3-phosphate dehydrogenase YP_002646392.1 3653448 R 561275 CDS YP_002646393.1 224991704 7561939 complement(3655286..3656701) 1 NC_012207.1 catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; flavoprotein disulfide reductase 3656701 lpdA_2 7561939 lpdA_2 Mycobacterium bovis BCG str. Tokyo 172 flavoprotein disulfide reductase YP_002646393.1 3655286 R 561275 CDS YP_002646394.1 224991705 7562854 3656904..3657383 1 NC_012207.1 hypothetical protein 3657383 7562854 JTY_3349 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646394.1 3656904 D 561275 CDS YP_002646395.1 224991706 7560909 complement(3657402..3658571) 1 NC_012207.1 N-acyl-L-amino acid amidohydrolase 3658571 amiA1_2 7560909 amiA1_2 Mycobacterium bovis BCG str. Tokyo 172 N-acyl-L-amino acid amidohydrolase YP_002646395.1 3657402 R 561275 CDS YP_002646396.1 224991707 7563966 complement(3658568..3659752) 1 NC_012207.1 amidase 3659752 amiB1_2 7563966 amiB1_2 Mycobacterium bovis BCG str. Tokyo 172 amidase YP_002646396.1 3658568 R 561275 CDS YP_002646397.1 224991708 7563970 3659817..3660623 1 NC_012207.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 3660623 deoD_2 7563970 deoD_2 Mycobacterium bovis BCG str. Tokyo 172 purine nucleoside phosphorylase YP_002646397.1 3659817 D 561275 CDS YP_002646398.1 224991709 7561481 3660627..3662231 1 NC_012207.1 Differs from Rv3308 by 1aa, G440S in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; phosphomannomutase 3662231 pmmB_2 7561481 pmmB_2 Mycobacterium bovis BCG str. Tokyo 172 phosphomannomutase YP_002646398.1 3660627 D 561275 CDS YP_002646399.1 224991710 7562132 complement(3662233..3662856) 1 NC_012207.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 3662856 upp 7562132 upp Mycobacterium bovis BCG str. Tokyo 172 uracil phosphoribosyltransferase YP_002646399.1 3662233 R 561275 CDS YP_002646400.1 224991711 7561660 3662961..3663860 1 NC_012207.1 Differs from Rv3310 by 1aa, A171T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acid phosphatase 3663860 sapM_2 7561660 sapM_2 Mycobacterium bovis BCG str. Tokyo 172 acid phosphatase YP_002646400.1 3662961 D 561275 CDS YP_002646401.1 224991712 7560756 3663884..3665146 1 NC_012207.1 hypothetical protein 3665146 7560756 JTY_3356 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646401.1 3663884 D 561275 CDS YP_002646402.1 224991713 7560910 complement(3665167..3666093) 1 NC_012207.1 hypothetical protein 3666093 7560910 JTY_3357 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646402.1 3665167 R 561275 CDS YP_002646403.1 224991714 7560911 complement(3666468..3666779) 1 NC_012207.1 hypothetical protein antigen 3666779 7560911 JTY_3358 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein antigen YP_002646403.1 3666468 R 561275 CDS YP_002646404.1 224991715 7560912 complement(3666850..3667947) 1 NC_012207.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 3667947 add_2 7560912 add_2 Mycobacterium bovis BCG str. Tokyo 172 adenosine deaminase YP_002646404.1 3666850 R 561275 CDS YP_002646405.1 224991716 7563938 complement(3667947..3669230) 1 NC_012207.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 3669230 deoA 7563938 deoA Mycobacterium bovis BCG str. Tokyo 172 thymidine phosphorylase YP_002646405.1 3667947 R 561275 CDS YP_002646406.1 224991717 7561477 complement(3669227..3669628) 1 NC_012207.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 3669628 cdd_2 7561477 cdd_2 Mycobacterium bovis BCG str. Tokyo 172 cytidine deaminase YP_002646406.1 3669227 R 561275 CDS YP_002646407.1 224991718 7562088 3669865..3670203 1 NC_012207.1 cytochrome b-556 subunit; succinate dehydrogenase 3670203 sdhC_2 7562088 sdhC_2 Mycobacterium bovis BCG str. Tokyo 172 succinate dehydrogenase YP_002646407.1 3669865 D 561275 CDS YP_002646408.1 224991719 7560765 3670200..3670634 1 NC_012207.1 Differs from Rv3317 by 1aa, L54V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrophobic membrane anchor subunit; succinate dehydrogenase 3670634 sdhD_2 7560765 sdhD_2 Mycobacterium bovis BCG str. Tokyo 172 succinate dehydrogenase YP_002646408.1 3670200 D 561275 CDS YP_002646409.1 224991720 7562058 complement(3672450..3673367) 1 NC_012207.1 Differs from Mb3328c by 1aa, D52N in Mycobacterium tuberculosis H37Rv, BCG Pasteur, and BCG Tokyo; hypothetical protein 3673367 7562058 JTY_3365 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646409.1 3672450 R 561275 CDS YP_002646410.1 224991721 7560913 complement(3673379..3674044) 1 NC_012207.1 Differs from Rv3301c and Mb3329c by 1aa, S74A in BCG Pasteur and BCG Tokyo; phosphate-transport system transcriptional regulatory protein PhoU homolog 1 3674044 phoY1_3 7560913 phoY1_3 Mycobacterium bovis BCG str. Tokyo 172 phosphate-transport system transcriptional regulatory protein PhoU homolog 1 YP_002646410.1 3673379 R 561275 CDS YP_002646411.1 224991722 7562417 complement(3674152..3675909) 1 NC_012207.1 glycerol-3-phosphate dehydrogenase 3675909 glpD2_3 7562417 glpD2_3 Mycobacterium bovis BCG str. Tokyo 172 glycerol-3-phosphate dehydrogenase YP_002646411.1 3674152 R 561275 CDS YP_002646412.1 224991723 7561940 complement(3675990..3677405) 1 NC_012207.1 catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; flavoprotein disulfide reductase 3677405 lpdA_3 7561940 lpdA_3 Mycobacterium bovis BCG str. Tokyo 172 flavoprotein disulfide reductase YP_002646412.1 3675990 R 561275 CDS YP_002646413.1 224991724 7562855 3677608..3678087 1 NC_012207.1 hypothetical protein 3678087 7562855 JTY_3369 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646413.1 3677608 D 561275 CDS YP_002646414.1 224991725 7560914 complement(3678106..3679275) 1 NC_012207.1 N-acyl-L-amino acid amidohydrolase 3679275 amiA1_3 7560914 amiA1_3 Mycobacterium bovis BCG str. Tokyo 172 N-acyl-L-amino acid amidohydrolase YP_002646414.1 3678106 R 561275 CDS YP_002646415.1 224991726 7563967 complement(3679272..3680456) 1 NC_012207.1 amidase 3680456 amiB1_3 7563967 amiB1_3 Mycobacterium bovis BCG str. Tokyo 172 amidase YP_002646415.1 3679272 R 561275 CDS YP_002646416.1 224991727 7563971 3680521..3681327 1 NC_012207.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 3681327 deoD_3 7563971 deoD_3 Mycobacterium bovis BCG str. Tokyo 172 purine nucleoside phosphorylase YP_002646416.1 3680521 D 561275 CDS YP_002646417.1 224991728 7561482 3681331..3682935 1 NC_012207.1 Differs from Rv3308 by 1aa, G440S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; phosphomannomutase 3682935 pmmB_3 7561482 pmmB_3 Mycobacterium bovis BCG str. Tokyo 172 phosphomannomutase YP_002646417.1 3681331 D 561275 CDS YP_002646418.1 224991729 7562133 complement(3682937..3683560) 1 NC_012207.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 3683560 upp 7562133 upp Mycobacterium bovis BCG str. Tokyo 172 uracil phosphoribosyltransferase YP_002646418.1 3682937 R 561275 CDS YP_002646419.1 224991730 7561661 3683665..3684564 1 NC_012207.1 Differs from Rv3310 by 1aa, A171T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acid phosphatase 3684564 sapM_3 7561661 sapM_3 Mycobacterium bovis BCG str. Tokyo 172 acid phosphatase YP_002646419.1 3683665 D 561275 CDS YP_002646420.1 224991731 7560757 3684588..3685850 1 NC_012207.1 hypothetical protein 3685850 7560757 JTY_3376 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646420.1 3684588 D 561275 CDS YP_002646421.1 224991732 7560915 complement(3685871..3686797) 1 NC_012207.1 hypothetical protein 3686797 7560915 JTY_3377 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646421.1 3685871 R 561275 CDS YP_002646422.1 224991733 7560916 complement(3687172..3687483) 1 NC_012207.1 hypothetical protein antigen 3687483 7560916 JTY_3378 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein antigen YP_002646422.1 3687172 R 561275 CDS YP_002646423.1 224991734 7560917 complement(3687554..3688651) 1 NC_012207.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 3688651 add_3 7560917 add_3 Mycobacterium bovis BCG str. Tokyo 172 adenosine deaminase YP_002646423.1 3687554 R 561275 CDS YP_002646424.1 224991735 7563939 complement(3688651..3689934) 1 NC_012207.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 3689934 deoA 7563939 deoA Mycobacterium bovis BCG str. Tokyo 172 thymidine phosphorylase YP_002646424.1 3688651 R 561275 CDS YP_002646425.1 224991736 7561478 complement(3689931..3690332) 1 NC_012207.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 3690332 cdd_3 7561478 cdd_3 Mycobacterium bovis BCG str. Tokyo 172 cytidine deaminase YP_002646425.1 3689931 R 561275 CDS YP_002646426.1 224991737 7562089 3690569..3690907 1 NC_012207.1 cytochrome b-556 subunit; succinate dehydrogenase 3690907 sdhC_3 7562089 sdhC_3 Mycobacterium bovis BCG str. Tokyo 172 succinate dehydrogenase YP_002646426.1 3690569 D 561275 CDS YP_002646427.1 224991738 7560766 3690904..3691338 1 NC_012207.1 Differs from Rv3317 by 1aa, L54V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrophobic membrane anchor subunit; succinate dehydrogenase 3691338 sdhD_3 7560766 sdhD_3 Mycobacterium bovis BCG str. Tokyo 172 succinate dehydrogenase YP_002646427.1 3690904 D 561275 CDS YP_002646428.1 224991739 7560769 3691618..3693240 1 NC_012207.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 3693240 sdhA 7560769 sdhA Mycobacterium bovis BCG str. Tokyo 172 succinate dehydrogenase flavoprotein subunit YP_002646428.1 3691618 D 561275 CDS YP_002646429.1 224991740 7560762 3693240..3694031 1 NC_012207.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 3694031 sdhB 7560762 sdhB Mycobacterium bovis BCG str. Tokyo 172 succinate dehydrogenase iron-sulfur subunit YP_002646429.1 3693240 D 561275 CDS YP_002646430.1 224991741 7560763 complement(3694110..3694538) 1 NC_012207.1 hypothetical protein 3694538 7560763 JTY_3386 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646430.1 3694110 R 561275 CDS YP_002646431.1 224991742 7560918 complement(3694542..3694784) 1 NC_012207.1 hypothetical protein 3694784 7560918 JTY_3387 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646431.1 3694542 R 561275 CDS YP_002646432.1 224991743 7560919 complement(3694906..3695520) 1 NC_012207.1 methyltransferase 3695520 7560919 JTY_3388 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase YP_002646432.1 3694906 R 561275 CDS YP_002646433.1 224991744 7560920 complement(3695517..3696182) 1 NC_012207.1 MoaD-MoaE fusion protein 3696182 moaX 7560920 moaX Mycobacterium bovis BCG str. Tokyo 172 MoaD-MoaE fusion protein YP_002646433.1 3695517 R 561275 CDS YP_002646434.1 224991745 7563534 complement(3696183..3696716) 1 NC_012207.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 3696716 moaC 7563534 moaC Mycobacterium bovis BCG str. Tokyo 172 molybdenum cofactor biosynthesis protein MoaC YP_002646434.1 3696183 R 561275 CDS YP_002646435.1 224991746 7563529 complement(3696713..3697087) 1 NC_012207.1 Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv; pterin-4-alpha-carbinolamine dehydratase 3697087 moaB3 7563529 moaB3 Mycobacterium bovis BCG str. Tokyo 172 pterin-4-alpha-carbinolamine dehydratase YP_002646435.1 3696713 R 561275 CDS YP_002646436.1 224991747 7563527 complement(3697184..3698248) 1 NC_012207.1 Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv; molybdenum cofactor biosynthesis protein A 3698248 moaA3 7563527 moaA3 Mycobacterium bovis BCG str. Tokyo 172 molybdenum cofactor biosynthesis protein A YP_002646436.1 3697184 R 561275 CDS YP_002646437.1 224991748 7563524 3698303..3698653 1 NC_012207.1 Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv but present in CDC1551 (CDS not annotated); hypothetical protein 3698653 7563524 JTY_3393 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646437.1 3698303 D 561275 CDS YP_002646438.1 224991749 7560921 3698631..3699017 1 NC_012207.1 Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv but present in CDC1551 (CDS not annotated); hypothetical protein 3699017 7560921 JTY_3394 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646438.1 3698631 D 561275 CDS YP_002646439.1 224991750 7560922 3698893..3700038 1 NC_012207.1 Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv; transcriptional regulatory protein 3700038 embR2 7560922 embR2 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646439.1 3698893 D 561275 CDS YP_002646440.1 224991751 7562861 complement(3700080..3700778) 1 NC_012207.1 Belongs to the RvD5 region. Absent from Mycobacterium tuberculosis strain H37Rv. In Mycobacterium bovis BCG Tokyo, 1b insertion leads to a shortly larger product compared with its homolog in Mycobacterium bovis (Mb3359c), Mycobacterium bovis, and BCG Pasteur (BCG_3396c) (232aa vs 214aa) and leads to product with different C-terminal part. 3Gs in BCG Tokyo, 2Gs in BCG Pasteur.; hypothetical protein 3700778 7562861 JTY_3396 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646440.1 3700080 R 561275 CDS YP_002646441.1 224991752 7560923 3700945..3702657 1 NC_012207.1 transposase fusion protein 3702657 7560923 JTY_3397 Mycobacterium bovis BCG str. Tokyo 172 transposase fusion protein YP_002646441.1 3700945 D 561275 CDS YP_002646442.1 224991753 7560924 complement(3702590..3703528) 1 NC_012207.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigJ 3703528 sigJ 7560924 sigJ Mycobacterium bovis BCG str. Tokyo 172 RNA polymerase sigma factor SigJ YP_002646442.1 3702590 R 561275 CDS YP_002646443.1 224991754 7561794 3703588..3704904 1 NC_012207.1 Differs from Rv3329 by 1aa, H122Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3704904 7561794 JTY_3399 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646443.1 3703588 D 561275 CDS YP_002646444.1 224991755 7560925 3704973..3706190 1 NC_012207.1 penicillin-binding protein 3706190 dacB1 7560925 dacB1 Mycobacterium bovis BCG str. Tokyo 172 penicillin-binding protein YP_002646444.1 3704973 D 561275 CDS YP_002646445.1 224991756 7561464 3706286..3707794 1 NC_012207.1 Differs from Mycobacterium bovis (Mb3364) and Mycobacterium bovis BCG Tokyo by 5aa in-frame deletion at position 465, and from Rv3331 by same deletion and 1aa, L423P in Mycobacterium bovis BCG Pasteur.; sugar-transport integral membrane protein 3707794 sugI 7561464 sugI Mycobacterium bovis BCG str. Tokyo 172 sugar-transport integral membrane protein YP_002646445.1 3706286 D 561275 CDS YP_002646446.1 224991757 7561818 3707791..3708942 1 NC_012207.1 N-acetylglucosamine-6-phosphate deacetylase 3708942 nagA 7561818 nagA Mycobacterium bovis BCG str. Tokyo 172 N-acetylglucosamine-6-phosphate deacetylase YP_002646446.1 3707791 D 561275 CDS YP_002646447.1 224991758 7563591 complement(3709133..3709978) 1 NC_012207.1 hypothetical protein 3709978 7563591 JTY_3403 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646447.1 3709133 R 561275 CDS YP_002646448.1 224991759 7560926 3710123..3710434 1 NC_012207.1 hypothetical protein 3710434 7560926 JTY_3404 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646448.1 3710123 D 561275 CDS YP_002646449.1 224991760 7560927 3710453..3710893 1 NC_012207.1 probably MerR-family; transcriptional regulatory protein 3710893 7560927 JTY_3405 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646449.1 3710453 D 561275 CDS YP_002646450.1 224991761 7560928 complement(3710927..3711796) 1 NC_012207.1 Differs from Rv3335c and Mb3368c by 1aa, V86A in BCG Pasteur and BCG Tokyo.; integral membrane protein 3711796 7560928 JTY_3406 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002646450.1 3710927 R 561275 CDS YP_002646451.1 224991762 7560929 complement(3711817..3712827) 1 NC_012207.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 3712827 trpS 7560929 trpS Mycobacterium bovis BCG str. Tokyo 172 tryptophanyl-tRNA synthetase YP_002646451.1 3711817 R 561275 CDS YP_002646452.1 224991763 7561634 3712852..3713745 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv3337 and Rv3338 exist as 2 genes with an overlap region between them. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-T) leads to a single product; hypothetical protein 3713745 7561634 JTY_3408 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646452.1 3712852 D 561275 CDS YP_002646453.1 224991764 7560930 complement(3713812..3715041) 1 NC_012207.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 3715041 icd1 7560930 icd1 Mycobacterium bovis BCG str. Tokyo 172 isocitrate dehydrogenase YP_002646453.1 3713812 R 561275 CDS YP_002646454.1 224991765 7563339 3715324..3716673 1 NC_012207.1 catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; O-acetylhomoserine aminocarboxypropyltransferase 3716673 metC 7563339 metC Mycobacterium bovis BCG str. Tokyo 172 O-acetylhomoserine aminocarboxypropyltransferase YP_002646454.1 3715324 D 561275 CDS YP_002646455.1 224991766 7564459 3716685..3717824 1 NC_012207.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase 3717824 metX 7564459 metX Mycobacterium bovis BCG str. Tokyo 172 homoserine O-acetyltransferase YP_002646455.1 3716685 D 561275 CDS YP_002646456.1 224991767 7564467 3717821..3718552 1 NC_012207.1 methyltransferase 3718552 7564467 JTY_3412 Mycobacterium bovis BCG str. Tokyo 172 methyltransferase YP_002646456.1 3717821 D 561275 CDS YP_002646457.1 224991768 7560931 complement(3718561..3722577) 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 3555 bp in-frame deletion (RD19) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Mb3375c by 1aa, A513V and from Rv3343c by several transitions in BCG Pasteur and BCG Tokyo.; PPE family protein 3722577 PPE54 7560931 PPE54 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002646457.1 3718561 R 561275 CDS YP_002646458.1 224991769 7562193 complement(3722626..3728256) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PE_PGRS50 and PE_PGRS49 exists as a single gene. In Mycobacterium bovis, a single base deletion (G-*) splits PE_PGRS50 into 2 parts, PE_PGRS50a and PE_PGRS50b and a single base deletion (C-*) leads to PE_PGRS49 and PE_PGRS50b existing as a single product. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, the first deletion is absent leading to an unique single gene comprising PE_PGRS50 and PE_PGRS49; hypothetical protein 3728256 PE_PGRS50 7562193 PE_PGRS50 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646458.1 3722626 R 561275 CDS YP_002646459.1 224991770 7562376 complement(3728680..3728937) 1 NC_012207.1 hypothetical protein 3728937 7562376 JTY_3415 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646459.1 3728680 R 561275 CDS YP_002646460.1 224991771 7562195 complement(3732375..3738665) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PPE55 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (G-*) splits PPE55 into 2 parts, PPE55a and PPE55b. Differs from Rv3347c by many aa substitutions and from Mb3380c by 1 aa, P1089S in BCG Pasteur and BCG Tokyo.; PPE Family protein 3738665 PPE55a 7562195 PPE55a Mycobacterium bovis BCG str. Tokyo 172 PPE Family protein YP_002646460.1 3732375 R 561275 CDS YP_002646461.1 224991772 7562194 3739245..3739736 1 NC_012207.1 transposase 3739736 7562194 JTY_3418 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646461.1 3739245 D 561275 CDS YP_002646462.1 224991773 7560933 complement(3739773..3740513) 1 NC_012207.1 transposase 3740513 7560933 JTY_3419 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646462.1 3739773 R 561275 CDS YP_002646463.1 224991774 7562197 complement(3751272..3752570) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, PPE56 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, 2 frameshifts due to single base transversion (C-A) and a single base deletion (G-*) splits PPE56 into 3 parts, PPE56a, PPE56b and PPE56d. Differs from Rv3350c and Mb3385c by 2aa deletion at position 291 in BCG Pasteur and BCG Tokyo.; PPE Family protein 3752570 PPE56a 7562197 PPE56a Mycobacterium bovis BCG str. Tokyo 172 PPE Family protein YP_002646463.1 3751272 R 561275 CDS YP_002646464.1 224991775 7562196 complement(3752814..3753608) 1 NC_012207.1 hypothetical protein 3753608 7562196 JTY_3423 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646464.1 3752814 R 561275 CDS YP_002646465.1 224991776 7560935 complement(3753690..3754061) 1 NC_012207.1 oxidoreductase 3754061 7560935 JTY_3424 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646465.1 3753690 R 561275 CDS YP_002646466.1 224991777 7560936 complement(3754204..3754464) 1 NC_012207.1 hypothetical protein 3754464 7560936 JTY_3425 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646466.1 3754204 R 561275 CDS YP_002646467.1 224991778 7560937 3754579..3754968 1 NC_012207.1 Differs from Rv3354 by 1aa, A112V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3754968 7560937 JTY_3426 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646467.1 3754579 D 561275 CDS YP_002646468.1 224991779 7560938 complement(3754982..3755275) 1 NC_012207.1 hypothetical protein 3755275 7560938 JTY_3427 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646468.1 3754982 R 561275 CDS YP_002646469.1 224991780 7560939 complement(3755272..3756117) 1 NC_012207.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 3756117 folD 7560939 folD Mycobacterium bovis BCG str. Tokyo 172 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_002646469.1 3755272 R 561275 CDS YP_002646470.1 224991781 7563421 3756241..3756516 1 NC_012207.1 hypothetical protein 3756516 7563421 JTY_3429 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646470.1 3756241 D 561275 CDS YP_002646471.1 224991782 7560940 3756513..3756770 1 NC_012207.1 hypothetical protein 3756770 7560940 JTY_3430 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646471.1 3756513 D 561275 CDS YP_002646472.1 224991783 7560941 3756812..3758002 1 NC_012207.1 oxidoreductase 3758002 7560941 JTY_3431 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646472.1 3756812 D 561275 CDS YP_002646473.1 224991784 7560942 3758119..3758487 1 NC_012207.1 hypothetical protein 3758487 7560942 JTY_3432 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646473.1 3758119 D 561275 CDS YP_002646474.1 224991785 7560943 complement(3758484..3759035) 1 NC_012207.1 hypothetical protein 3759035 7560943 JTY_3433 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646474.1 3758484 R 561275 CDS YP_002646475.1 224991786 7560944 complement(3759042..3759623) 1 NC_012207.1 ATP/GTP-binding protein 3759623 7560944 JTY_3434 Mycobacterium bovis BCG str. Tokyo 172 ATP/GTP-binding protein YP_002646475.1 3759042 R 561275 CDS YP_002646476.1 224991787 7560945 complement(3759604..3759972) 1 NC_012207.1 hypothetical protein 3759972 7560945 JTY_3435 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646476.1 3759604 R 561275 CDS YP_002646477.1 224991788 7560946 complement(3759950..3760342) 1 NC_012207.1 Differs from Rv3364c and Mb3399c, by 1aa, L22P in BCG Pasteur and BCG Tokyo; hypothetical protein 3760342 7560946 JTY_3436 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646477.1 3759950 R 561275 CDS YP_002646478.1 224991789 7560947 complement(3760339..3762969) 1 NC_012207.1 hypothetical protein 3762969 7560947 JTY_3437 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646478.1 3760339 R 561275 CDS YP_002646479.1 224991790 7560948 3763205..3763669 1 NC_012207.1 tRNA/rRNA methylase 3763669 spoU 7560948 spoU Mycobacterium bovis BCG str. Tokyo 172 tRNA/rRNA methylase YP_002646479.1 3763205 D 561275 CDS YP_002646480.1 224991791 7561805 3764036..3765811 1 NC_012207.1 In Mycobacterium bovis, insertions of 105 bp and of 9 bp (*-GGCAGCGGT) lead to longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (626 aa versus 588 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, there is no 105 bp insertion but the 9 bp insertion is presentat codon 404. Differs also from Rv3367 by 1aa, S412G in BCG Pasteur and BCG Tokyo; PE-PGRS family protein 3765811 PE_PGRS51 7561805 PE_PGRS51 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002646480.1 3764036 D 561275 CDS YP_002646481.1 224991792 7562377 complement(3765812..3766456) 1 NC_012207.1 oxidoreductase 3766456 7562377 JTY_3440 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646481.1 3765812 R 561275 CDS YP_002646482.1 224991793 7560949 3766455..3766889 1 NC_012207.1 hypothetical protein 3766889 7560949 JTY_3441 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646482.1 3766455 D 561275 CDS YP_002646483.1 224991794 7560950 complement(3766978..3770217) 1 NC_012207.1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase.; error-prone DNA polymerase 3770217 dnaE2 7560950 dnaE2 Mycobacterium bovis BCG str. Tokyo 172 error-prone DNA polymerase YP_002646483.1 3766978 R 561275 CDS YP_002646484.1 224991795 7561502 3770409..3771749 1 NC_012207.1 Differs from Rv3371 by 2aa, G339R, V368I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3771749 7561502 JTY_3443 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646484.1 3770409 D 561275 CDS YP_002646485.1 224991796 7560951 3771791..3772966 1 NC_012207.1 trehalose 6-phosphate phosphatase 3772966 otsB2 7560951 otsB2 Mycobacterium bovis BCG str. Tokyo 172 trehalose 6-phosphate phosphatase YP_002646485.1 3771791 D 561275 CDS YP_002646486.1 224991797 7562504 3773203..3774093 1 NC_012207.1 In Mycobacterium tuberculosis H37Rv, echA18 and echA18' exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transversion (t-g) leads to a single product; enoyl-CoA hydratase 3774093 echA18 7562504 echA18 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002646486.1 3773203 D 561275 CDS YP_002646487.1 224991798 7561529 3774098..3775525 1 NC_012207.1 amidase 3775525 amiD 7561529 amiD Mycobacterium bovis BCG str. Tokyo 172 amidase YP_002646487.1 3774098 D 561275 CDS YP_002646488.1 224991799 7563974 3775633..3776286 1 NC_012207.1 hypothetical protein 3776286 7563974 JTY_3447 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646488.1 3775633 D 561275 CDS YP_002646489.1 224991800 7560952 complement(3776378..3777829) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a 4 bp to 3 bp substitution (CAAT-AAC) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; cyclase 3777829 7560952 JTY_3448 Mycobacterium bovis BCG str. Tokyo 172 cyclase YP_002646489.1 3776378 R 561275 CDS YP_002646490.1 224991801 7560953 complement(3777834..3778724) 1 NC_012207.1 Differs from Rv3378c and Mb3412c by 1aa, A137V in BCG Pasteur and BCG Tokyo; hypothetical protein 3778724 7560953 JTY_3449 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646490.1 3777834 R 561275 CDS YP_002646491.1 224991802 7560954 complement(3778733..3780343) 1 NC_012207.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 3780343 dxs2 7560954 dxs2 Mycobacterium bovis BCG str. Tokyo 172 1-deoxy-D-xylulose-5-phosphate synthase YP_002646491.1 3778733 R 561275 CDS YP_002646492.1 224991803 7561521 complement(3780568..3781557) 1 NC_012207.1 lytB-related protein 3781557 lytB1 7561521 lytB1 Mycobacterium bovis BCG str. Tokyo 172 lytB-related protein YP_002646492.1 3780568 R 561275 CDS YP_002646493.1 224991804 7560546 complement(3781557..3782609) 1 NC_012207.1 Differs from Rv3383c by 1aa, G132V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; polyprenyl synthetase 3782609 idsB 7560546 idsB Mycobacterium bovis BCG str. Tokyo 172 polyprenyl synthetase YP_002646493.1 3781557 R 561275 CDS YP_002646494.1 224991805 7563346 complement(3783363..3783755) 1 NC_012207.1 hypothetical protein 3783755 7563346 JTY_3453 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646494.1 3783363 R 561275 CDS YP_002646495.1 224991806 7560955 complement(3783755..3784063) 1 NC_012207.1 hypothetical protein 3784063 7560955 JTY_3454 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646495.1 3783755 R 561275 CDS YP_002646496.1 224991807 7560956 3784212..3784916 1 NC_012207.1 transposase 3784916 7560956 JTY_3455 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646496.1 3784212 D 561275 CDS YP_002646497.1 224991808 7560957 3784906..3785583 1 NC_012207.1 transposase 3785583 7560957 JTY_3456 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646497.1 3784906 D 561275 CDS YP_002646498.1 224991809 7564004 3785773..3788025 1 NC_012207.1 In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur and BCG Tokyo, insertions of 60 bp and 78 bp, and deletions of 75 bp and 9 bp (CGGCGGCGC-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (750 aa and 749 aa versus 731 aa). Differs from Mb3420 by 1aa insertion, A205 in BCG Pasteur and BCG Tokyo; PE-PGRS family protein 3788025 PE_PGRS52 7564004 PE_PGRS52 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002646498.1 3785773 D 561275 CDS YP_002646499.1 224991810 7562378 complement(3788096..3788968) 1 NC_012207.1 Differs from Mb3421c by 1aa, P172L in Mycobacteirum tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; dehydrogenase 3788968 7562378 JTY_3458 Mycobacterium bovis BCG str. Tokyo 172 dehydrogenase YP_002646499.1 3788096 R 561275 CDS YP_002646500.1 224991811 7564005 3789042..3789752 1 NC_012207.1 lipoprotein 3789752 lpqD 7564005 lpqD Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002646500.1 3789042 D 561275 CDS YP_002646501.1 224991812 7560496 3789798..3791750 1 NC_012207.1 short chain dehydrogenase 3791750 acrA1 7560496 acrA1 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002646501.1 3789798 D 561275 CDS YP_002646502.1 224991813 7563934 complement(3791751..3792614) 1 NC_012207.1 Differs from Rv3392c by 1aa, S112N in Mycobacteirum bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cyclopropane-fatty-acyl-phospholipid synthase 1 3792614 cmaA1 7563934 cmaA1 Mycobacterium bovis BCG str. Tokyo 172 cyclopropane-fatty-acyl-phospholipid synthase 1 YP_002646502.1 3791751 R 561275 CDS YP_002646503.1 224991814 7562114 3792638..3793564 1 NC_012207.1 nucleoside hydrolase 3793564 iunH 7562114 iunH Mycobacterium bovis BCG str. Tokyo 172 nucleoside hydrolase YP_002646503.1 3792638 D 561275 CDS YP_002646504.1 224991815 7562797 complement(3793619..3795202) 1 NC_012207.1 hypothetical protein 3795202 7562797 JTY_3463 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646504.1 3793619 R 561275 CDS YP_002646505.1 224991816 7564006 complement(3795199..3795813) 1 NC_012207.1 Differs from Rv3395c by 2aa, V3A, M104V in Mycobacteirum bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3795813 7564006 JTY_3464 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646505.1 3795199 R 561275 CDS YP_002646506.1 224991817 7564007 3795896..3796522 1 NC_012207.1 hypothetical protein 3796522 7564007 JTY_3465 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646506.1 3795896 D 561275 CDS YP_002646507.1 224991818 7564008 complement(3796678..3798255) 1 NC_012207.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 3798255 guaA 7564008 guaA Mycobacterium bovis BCG str. Tokyo 172 GMP synthase YP_002646507.1 3796678 R 561275 CDS YP_002646508.1 224991819 7563287 complement(3798267..3799175) 1 NC_012207.1 phytoene synthase 3799175 phyA 7563287 phyA Mycobacterium bovis BCG str. Tokyo 172 phytoene synthase YP_002646508.1 3798267 R 561275 CDS YP_002646509.1 224991820 7562420 complement(3799204..3800283) 1 NC_012207.1 multifunctional geranylgeranyl pyrophosphate synthetase 3800283 idsA1 7562420 idsA1 Mycobacterium bovis BCG str. Tokyo 172 multifunctional geranylgeranyl pyrophosphate synthetase YP_002646509.1 3799204 R 561275 CDS YP_002646510.1 224991821 7563344 3800306..3801352 1 NC_012207.1 Differs from Rv3399 by 1aa, E330A in Mycobacterium tuberculosis CDC1551, Mycobacteirum bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3801352 7563344 JTY_3469 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646510.1 3800306 D 561275 CDS YP_002646511.1 224991822 7564009 3801416..3802204 1 NC_012207.1 hydrolase 3802204 7564009 JTY_3470 Mycobacterium bovis BCG str. Tokyo 172 hydrolase YP_002646511.1 3801416 D 561275 CDS YP_002646512.1 224991823 7564010 3802219..3804579 1 NC_012207.1 Differs from Mb3434 by 1aa, R658H in Mycobacterium bovis BCG Pasteur and by 2aa, R658H, R750L in Mycobacterium bovis BCG Tokyo.; hypothetical protein 3804579 7564010 JTY_3471 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646512.1 3802219 D 561275 CDS YP_002646513.1 224991824 7564011 complement(3805195..3806247) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur and BCG Tokyo, and Mycobacterium bovis, a single base transversion (c-g) leads to a shorter product. Differs from Mb3436c by 1aa, R154C in BCG Pasteur and BCG Tokyo; hypothetical protein 3806247 7564011 JTY_3472 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646513.1 3805195 R 561275 CDS YP_002646514.1 224991825 7564012 complement(3806618..3808219) 1 NC_012207.1 hypothetical protein 3808219 7564012 JTY_3473 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646514.1 3806618 R 561275 CDS YP_002646515.1 224991826 7564013 complement(3808236..3808940) 1 NC_012207.1 hypothetical protein 3808940 7564013 JTY_3474 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646515.1 3808236 R 561275 CDS YP_002646516.1 224991827 7564015 3809664..3810551 1 NC_012207.1 dioxygenase 3810551 7564015 JTY_3476 Mycobacterium bovis BCG str. Tokyo 172 dioxygenase YP_002646516.1 3809664 D 561275 CDS YP_002646517.1 224991828 7564016 3810586..3810885 1 NC_012207.1 hypothetical protein 3810885 7564016 JTY_3477 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646517.1 3810586 D 561275 CDS YP_002646518.1 224991829 7564017 3810882..3811292 1 NC_012207.1 Differs from Rv3408 by 1aa, L46S in Mycobacteirum bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3811292 7564017 JTY_3478 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646518.1 3810882 D 561275 CDS YP_002646519.1 224991830 7564018 complement(3811325..3813061) 1 NC_012207.1 cholesterol oxidase precursor 3813061 choD 7564018 choD Mycobacterium bovis BCG str. Tokyo 172 cholesterol oxidase precursor YP_002646519.1 3811325 R 561275 CDS YP_002646520.1 224991831 7562103 complement(3813117..3814244) 1 NC_012207.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 3814244 guaB3 7562103 guaB3 Mycobacterium bovis BCG str. Tokyo 172 inosine 5-monophosphate dehydrogenase YP_002646520.1 3813117 R 561275 CDS YP_002646521.1 224991832 7563290 complement(3814264..3815853) 1 NC_012207.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 3815853 guaB2 7563290 guaB2 Mycobacterium bovis BCG str. Tokyo 172 inosine 5'-monophosphate dehydrogenase YP_002646521.1 3814264 R 561275 CDS YP_002646522.1 224991833 7563289 3816060..3816470 1 NC_012207.1 hypothetical protein 3816470 7563289 JTY_3482 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646522.1 3816060 D 561275 CDS YP_002646523.1 224991834 7564019 complement(3816480..3817379) 1 NC_012207.1 hypothetical alanine and proline rich protein 3817379 7564019 JTY_3483 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine and proline rich protein YP_002646523.1 3816480 R 561275 CDS YP_002646524.1 224991835 7564020 complement(3817372..3818010) 1 NC_012207.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase; RNA polymerase sigma factor SigD 3818010 sigD 7564020 sigD Mycobacterium bovis BCG str. Tokyo 172 RNA polymerase sigma factor SigD YP_002646524.1 3817372 R 561275 CDS YP_002646525.1 224991836 7560792 complement(3818028..3818855) 1 NC_012207.1 hypothetical protein 3818855 7560792 JTY_3485 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646525.1 3818028 R 561275 CDS YP_002646526.1 224991837 7564021 3819226..3819534 1 NC_012207.1 transcriptional regulatory protein whiB-like 3819534 whiB3 7564021 whiB3 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein whiB-like YP_002646526.1 3819226 D 561275 CDS YP_002646527.1 224991838 7561691 complement(3819606..3821225) 1 NC_012207.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth; molecular chaperone GroEL 3821225 groEL 7561691 groEL Mycobacterium bovis BCG str. Tokyo 172 molecular chaperone GroEL YP_002646527.1 3819606 R 561275 CDS YP_002646528.1 224991839 7563283 complement(3821320..3821622) 1 NC_012207.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 3821622 groES 7563283 groES Mycobacterium bovis BCG str. Tokyo 172 co-chaperonin GroES YP_002646528.1 3821320 R 561275 CDS YP_002646529.1 224991840 7563284 complement(3821889..3822923) 1 NC_012207.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 3822923 gcp 7563284 gcp Mycobacterium bovis BCG str. Tokyo 172 DNA-binding/iron metalloprotein/AP endonuclease YP_002646529.1 3821889 R 561275 CDS YP_002646530.1 224991841 7561907 complement(3822920..3823396) 1 NC_012207.1 ribosomal-protein-alanine acetyltransferase 3823396 rimI 7561907 rimI Mycobacterium bovis BCG str. Tokyo 172 ribosomal-protein-alanine acetyltransferase YP_002646530.1 3822920 R 561275 CDS YP_002646531.1 224991842 7561578 complement(3823393..3824028) 1 NC_012207.1 hypothetical protein 3824028 7561578 JTY_3491 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646531.1 3823393 R 561275 CDS YP_002646532.1 224991843 7564022 complement(3824025..3824531) 1 NC_012207.1 hypothetical protein 3824531 7564022 JTY_3492 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646532.1 3824025 R 561275 CDS YP_002646533.1 224991844 7564023 complement(3824528..3825754) 1 NC_012207.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 3825754 alr 7564023 alr Mycobacterium bovis BCG str. Tokyo 172 alanine racemase YP_002646533.1 3824528 R 561275 CDS YP_002646534.1 224991845 7563964 complement(3826048..3826410) 1 NC_012207.1 hypothetical protein 3826410 7563964 JTY_3494 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646534.1 3826048 R 561275 CDS YP_002646535.1 224991846 7564024 3826573..3827109 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a large deletion of 4926 bp (RD6) leads to the loss of the COOH part of PPE57, and the following CDSs, PPE58, Rv3427c, Rv3428c and the NH2-part of PPE59 compared to Mycobacterium tuberculosis strain H37Rv; PPE family protein 3827109 PPE57 7564024 PPE57 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002646535.1 3826573 D 561275 CDS YP_002646536.1 224991847 7562199 complement(3827050..3828213) 1 NC_012207.1 Differs from Mb3460c by 1aa, R233H in Mycobacteirum tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transposase 3828213 7562199 JTY_3496 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646536.1 3827050 R 561275 CDS YP_002646537.1 224991848 7564025 complement(3828702..3829547) 1 NC_012207.1 transposase 3829547 7564025 JTY_3497 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646537.1 3828702 R 561275 CDS YP_002646538.1 224991849 7564026 complement(3829780..3831162) 1 NC_012207.1 glutamate decarboxylase 3831162 gadB 7564026 gadB Mycobacterium bovis BCG str. Tokyo 172 glutamate decarboxylase YP_002646538.1 3829780 R 561275 CDS YP_002646539.1 224991850 7561895 complement(3831200..3832621) 1 NC_012207.1 Differs from Mb3463c by 1aa, A436 deleted, and from Rv3433c by 2aa, A436 deleted, A442S in Mycobacterium bovis BCG Pasteur. Differs from Rv3433c by 1aa, A442S in Mycobacterium bovis BCG Tokyo.; hypothetical protein 3832621 7561895 JTY_3499 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646539.1 3831200 R 561275 CDS YP_002646540.1 224991851 7564027 complement(3832623..3833336) 1 NC_012207.1 Differs from Mb3464c by 1aa, A193T in Mycobacteirum tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 3833336 7564027 JTY_3500 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646540.1 3832623 R 561275 CDS YP_002646541.1 224991852 7564028 complement(3833347..3834201) 1 NC_012207.1 transmembrane protein 3834201 7564028 JTY_3501 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646541.1 3833347 R 561275 CDS YP_002646542.1 224991853 7564029 complement(3834423..3836297) 1 NC_012207.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 3836297 glmS 7564029 glmS Mycobacterium bovis BCG str. Tokyo 172 glucosamine--fructose-6-phosphate aminotransferase YP_002646542.1 3834423 R 561275 CDS YP_002646543.1 224991854 7561924 3836319..3836795 1 NC_012207.1 Differs from Rv3437 by 1aa P84L in Mycobacteirum bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 3836795 7561924 JTY_3503 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646543.1 3836319 D 561275 CDS YP_002646544.1 224991855 7564030 3836805..3837647 1 NC_012207.1 hypothetical protein 3837647 7564030 JTY_3504 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646544.1 3836805 D 561275 CDS YP_002646545.1 224991856 7564031 complement(3837667..3839070) 1 NC_012207.1 hypothetical alanine and proline rich protein 3839070 7564031 JTY_3505 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine and proline rich protein YP_002646545.1 3837667 R 561275 CDS YP_002646546.1 224991857 7564032 complement(3839073..3839384) 1 NC_012207.1 hypothetical protein 3839384 7564032 JTY_3506 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646546.1 3839073 R 561275 CDS YP_002646547.1 224991858 7564033 complement(3839432..3840778) 1 NC_012207.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 3840778 glmM 7564033 glmM Mycobacterium bovis BCG str. Tokyo 172 phosphoglucosamine mutase YP_002646547.1 3839432 R 561275 CDS YP_002646548.1 224991859 7563562 complement(3840903..3841358) 1 NC_012207.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 3841358 rpsI 7563562 rpsI Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S9 YP_002646548.1 3840903 R 561275 CDS YP_002646549.1 224991860 7560736 complement(3841355..3841798) 1 NC_012207.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 3841798 rplM 7560736 rplM Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L13 YP_002646549.1 3841355 R 561275 CDS YP_002646550.1 224991861 7561613 complement(3842031..3842333) 1 NC_012207.1 hypothetical protein 3842333 esxT 7561613 esxT Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646550.1 3842031 R 561275 CDS YP_002646551.1 224991862 7562890 complement(3842354..3842731) 1 NC_012207.1 hypothetical protein 3842731 esxU 7562890 esxU Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646551.1 3842354 R 561275 CDS YP_002646552.1 224991863 7562891 complement(3842724..3843938) 1 NC_012207.1 hypothetical alanine and valine rich protein 3843938 7562891 JTY_3512 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine and valine rich protein YP_002646552.1 3842724 R 561275 CDS YP_002646553.1 224991864 7564034 complement(3843935..3847645) 1 NC_012207.1 Differs from Rv3444c by 1 aa, G1082S and Mb3477c by 1 aa G1159S in BCG Pasteur and BCG Tokyo; hypothetical protein 3847645 7564034 JTY_3513 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646553.1 3843935 R 561275 CDS YP_002646554.1 224991865 7564035 3847759..3849162 1 NC_012207.1 Differs from Mb3478 by 1aa A265D in Mycobacteirum tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein 3849162 7564035 JTY_3514 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002646554.1 3847759 D 561275 CDS YP_002646555.1 224991866 7564036 3849159..3850526 1 NC_012207.1 serine protease 3850526 7564036 JTY_3515 Mycobacterium bovis BCG str. Tokyo 172 serine protease YP_002646555.1 3849159 D 561275 CDS YP_002646556.1 224991867 7564037 complement(3850491..3851903) 1 NC_012207.1 hypothetical protein 3851903 7564037 JTY_3516 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646556.1 3850491 R 561275 CDS YP_002646557.1 224991868 7564038 3852024..3852812 1 NC_012207.1 Differs from Rv3451 and Mb3481 by deletion of 1aa,262R in BCG Pasteur and BCG Tokyo; cutinase precursor 3852812 cut3 7564038 cut3 Mycobacterium bovis BCG str. Tokyo 172 cutinase precursor YP_002646557.1 3852024 D 561275 CDS YP_002646558.1 224991869 7563144 3852859..3853539 1 NC_012207.1 cutinase precursor 3853539 cut4 7563144 cut4 Mycobacterium bovis BCG str. Tokyo 172 cutinase precursor YP_002646558.1 3852859 D 561275 CDS YP_002646559.1 224991870 7563145 3853811..3855496 1 NC_012207.1 In Mycobacterium tuberculosis H37Rv, Rv3453 and Rv3454 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base deletion (T-*) results in a single product that is more similar to Rv3454. Differs from Mb3483 by 1aa, V328I in BCG Pasteur and BCG Tokyo; transmembrane protein 3855496 7563145 JTY_3519 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646559.1 3853811 D 561275 CDS YP_002646560.1 224991871 7564039 complement(3855458..3856228) 1 NC_012207.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 3856228 truA 7564039 truA Mycobacterium bovis BCG str. Tokyo 172 tRNA pseudouridine synthase A YP_002646560.1 3855458 R 561275 CDS YP_002646561.1 224991872 7561636 complement(3856296..3856838) 1 NC_012207.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 3856838 rplQ 7561636 rplQ Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L17 YP_002646561.1 3856296 R 561275 CDS YP_002646562.1 224991873 7561617 complement(3856870..3857913) 1 NC_012207.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 3857913 rpoA 7561617 rpoA Mycobacterium bovis BCG str. Tokyo 172 DNA-directed RNA polymerase subunit alpha YP_002646562.1 3856870 R 561275 CDS YP_002646563.1 224991874 7560724 complement(3858064..3858669) 1 NC_012207.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 3858669 rpsD 7560724 rpsD Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S4 YP_002646563.1 3858064 R 561275 CDS YP_002646564.1 224991875 7560731 complement(3858678..3859097) 1 NC_012207.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 3859097 rpsK 7560731 rpsK Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S11 YP_002646564.1 3858678 R 561275 CDS YP_002646565.1 224991876 7560738 complement(3859101..3859475) 1 NC_012207.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 3859475 rpsM 7560738 rpsM Mycobacterium bovis BCG str. Tokyo 172 30S ribosomal protein S13 YP_002646565.1 3859101 R 561275 CDS YP_002646566.1 224991877 7560740 complement(3859691..3859804) 1 NC_012207.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 3859804 rpmJ 7560740 rpmJ Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L36 YP_002646566.1 3859691 R 561275 CDS YP_002646567.1 224991878 7560723 complement(3859837..3860058) 1 NC_012207.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 3860058 infA 7560723 infA Mycobacterium bovis BCG str. Tokyo 172 translation initiation factor IF-1 YP_002646567.1 3859837 R 561275 CDS YP_002646568.1 224991879 7562785 3860312..3861169 1 NC_012207.1 hypothetical protein 3861169 7562785 JTY_3528 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646568.1 3860312 D 561275 CDS YP_002646569.1 224991880 7564040 3861242..3862237 1 NC_012207.1 dTDP-glucose 4,6-dehydratase 3862237 rmlB1 7564040 rmlB1 Mycobacterium bovis BCG str. Tokyo 172 dTDP-glucose 4,6-dehydratase YP_002646569.1 3861242 D 561275 CDS YP_002646570.1 224991881 7561582 3862239..3862847 1 NC_012207.1 dTDP-4-dehydrorhamnose 3,5-epimerase 3862847 rmlC 7561582 rmlC Mycobacterium bovis BCG str. Tokyo 172 dTDP-4-dehydrorhamnose 3,5-epimerase YP_002646570.1 3862239 D 561275 CDS YP_002646571.1 224991882 7561584 3862930..3863598 1 NC_012207.1 Differs from Rv3466 by 4aa, T56A, T63A, L91R, I131V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3863598 7561584 JTY_3531 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646571.1 3862930 D 561275 CDS YP_002646572.1 224991883 7564041 3863369..3864322 1 NC_012207.1 Differs from Rv3467 by 6aa, E134K, G245A, D262G, R275H, K276N, E315K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3864322 7564041 JTY_3532 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646572.1 3863369 D 561275 CDS YP_002646573.1 224991884 7564042 complement(3864380..3865474) 1 NC_012207.1 Differs from Rv3468c by 1aa, V62I in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; dTDP-glucose 4,6-dehydratase 3865474 rmlB2 7564042 rmlB2 Mycobacterium bovis BCG str. Tokyo 172 dTDP-glucose 4,6-dehydratase YP_002646573.1 3864380 R 561275 CDS YP_002646574.1 224991885 7561583 complement(3865478..3866488) 1 NC_012207.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 3866488 mhpE 7561583 mhpE Mycobacterium bovis BCG str. Tokyo 172 4-hydroxy-2-ketovalerate aldolase YP_002646574.1 3865478 R 561275 CDS YP_002646575.1 224991886 7564472 complement(3866549..3868207) 1 NC_012207.1 Differs from Mb3499c by 1aa, G421E in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acetolactate synthase large subunit 3868207 ilvB2 7564472 ilvB2 Mycobacterium bovis BCG str. Tokyo 172 acetolactate synthase large subunit YP_002646575.1 3866549 R 561275 CDS YP_002646576.1 224991887 7562777 complement(3868213..3868746) 1 NC_012207.1 Differs from Mb3500c by 1aa, C155W in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3868746 7562777 JTY_3536 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646576.1 3868213 R 561275 CDS YP_002646577.1 224991888 7564043 3868767..3869273 1 NC_012207.1 hypothetical protein 3869273 7564043 JTY_3537 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646577.1 3868767 D 561275 CDS YP_002646578.1 224991889 7564044 complement(3869353..3870138) 1 NC_012207.1 peroxidase 3870138 bpoA 7564044 bpoA Mycobacterium bovis BCG str. Tokyo 172 peroxidase YP_002646578.1 3869353 R 561275 CDS YP_002646579.1 224991890 7562076 complement(3870418..3871767) 1 NC_012207.1 Differs from Rv3476c by 2aa, F81L, V144A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; dicarboxylic acid transport integral membrane protein 3871767 kgtP 7562076 kgtP Mycobacterium bovis BCG str. Tokyo 172 dicarboxylic acid transport integral membrane protein YP_002646579.1 3870418 R 561275 CDS YP_002646580.1 224991891 7562808 3872140..3872436 1 NC_012207.1 Differs from Rv3477 by 1aa, A26V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PE family protein 3872436 PE31 7562808 PE31 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002646580.1 3872140 D 561275 CDS YP_002646581.1 224991892 7561731 3872473..3873654 1 NC_012207.1 PE family protein 3873654 PPE60 7561731 PPE60 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002646581.1 3872473 D 561275 CDS YP_002646582.1 224991893 7560794 3873867..3875168 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv3479 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and BCG Tokyo, and Mycobacterium bovis, a 713 bp deletion (RD18) splits Rv3479 into 2 parts, Mb3507 and Mb3508. Differs from Rv3479 by 1aa, R174L in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 3875168 7560794 JTY_3542 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646582.1 3873867 D 561275 CDS YP_002646583.1 224991894 7564045 3875173..3876219 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv3479 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 713 bp deletion (RD18) splits Rv3479 into 2 parts, Mb3507 and Mb3508. Differs from Rv3479 by 1aa, N344T in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 3876219 7564045 JTY_3543 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646583.1 3875173 D 561275 CDS YP_002646584.1 224991895 7564046 complement(3876243..3877736) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv (Rv3480c), BCG Pasteur and BCG Tokyo, exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (GT-*) splits Rv3480c into 2 parts, Mb3509c and Mb3510c. Differs from Rv3480c and Mb3510c by 1aa, N205D; hypothetical protein 3877736 7564046 JTY_3544 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646584.1 3876243 R 561275 CDS YP_002646585.1 224991896 7564047 complement(3877827..3878516) 1 NC_012207.1 integral membrane protein 3878516 7564047 JTY_3545 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002646585.1 3877827 R 561275 CDS YP_002646586.1 224991897 7564048 complement(3877951..3879441) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur (BCG_3546c) and BCG Tokyo, a single base insertion (C) at position equivalent to Mycobacterium tuberculosis H37Rv position 3901442-3901443 leads to frameshift and longer product of 496 aa compared to Rv3482c, len: 260 aa; hypothetical protein 3879441 7564048 JTY_3546 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646586.1 3877951 R 561275 CDS YP_002646587.1 224991898 7564049 complement(3879485..3880147) 1 NC_012207.1 hypothetical protein 3880147 7564049 JTY_3547 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646587.1 3879485 R 561275 CDS YP_002646588.1 224991899 7564050 3880413..3881951 1 NC_012207.1 hypothetical protein 3881951 cpsA 7564050 cpsA Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646588.1 3880413 D 561275 CDS YP_002646589.1 224991900 7563121 complement(3881957..3882901) 1 NC_012207.1 short chain dehydrogenase 3882901 7563121 JTY_3549 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002646589.1 3881957 R 561275 CDS YP_002646590.1 224991901 7564051 3883107..3883556 1 NC_012207.1 hypothetical protein 3883556 7564051 JTY_3550 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646590.1 3883107 D 561275 CDS YP_002646591.1 224991902 7564052 complement(3883509..3884342) 1 NC_012207.1 esterase/lipase 3884342 lipF 7564052 lipF Mycobacterium bovis BCG str. Tokyo 172 esterase/lipase YP_002646591.1 3883509 R 561275 CDS YP_002646592.1 224991903 7562834 3885002..3885325 1 NC_012207.1 Differs from Rv3488 by 1aa, R98G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein 3885325 7562834 JTY_3552 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646592.1 3885002 D 561275 CDS YP_002646593.1 224991904 7564053 3885407..3885571 1 NC_012207.1 hypothetical protein 3885571 7564053 JTY_3553 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646593.1 3885407 D 561275 CDS YP_002646594.1 224991905 7564054 3885571..3887073 1 NC_012207.1 Differs from Rv3490 by 1aa, L334V in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo.; UDP-forming; alpha,alpha-trehalose-phosphate synthase 3887073 otsA 7564054 otsA Mycobacterium bovis BCG str. Tokyo 172 alpha,alpha-trehalose-phosphate synthase YP_002646594.1 3885571 D 561275 CDS YP_002646595.1 224991906 7562502 3887225..3887803 1 NC_012207.1 hypothetical protein 3887803 7562502 JTY_3555 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646595.1 3887225 D 561275 CDS YP_002646596.1 224991907 7564055 complement(3887800..3888282) 1 NC_012207.1 hypothetical protein 3888282 7564055 JTY_3556 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646596.1 3887800 R 561275 CDS YP_002646597.1 224991908 7564056 complement(3888282..3889010) 1 NC_012207.1 hypothetical protein 3889010 7564056 JTY_3557 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646597.1 3888282 R 561275 CDS YP_002646598.1 224991909 7564057 complement(3889010..3890704) 1 NC_012207.1 Differs from Rv3494c by 1aa, G245D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; MCE-family protein 3890704 mce4F 7564057 mce4F Mycobacterium bovis BCG str. Tokyo 172 MCE-family protein YP_002646598.1 3889010 R 561275 CDS YP_002646599.1 224991910 7564446 complement(3890715..3891869) 1 NC_012207.1 MCE-family lipoprotein 3891869 lprN 7564446 lprN Mycobacterium bovis BCG str. Tokyo 172 MCE-family lipoprotein YP_002646599.1 3890715 R 561275 CDS YP_002646600.1 224991911 7560531 complement(3891866..3893221) 1 NC_012207.1 MCE-family protein 3893221 mce4D 7560531 mce4D Mycobacterium bovis BCG str. Tokyo 172 MCE-family protein YP_002646600.1 3891866 R 561275 CDS YP_002646601.1 224991912 7564445 complement(3893218..3894291) 1 NC_012207.1 Differs from Mb3527c and Rv3497c by 1aa, P46T in BCG Pasteur and BCG Tokyo.; MCE-family protein 3894291 mce4C 7564445 mce4C Mycobacterium bovis BCG str. Tokyo 172 MCE-family protein YP_002646601.1 3893218 R 561275 CDS YP_002646602.1 224991913 7564444 complement(3894281..3895333) 1 NC_012207.1 MCE-family protein 3895333 mce4B 7564444 mce4B Mycobacterium bovis BCG str. Tokyo 172 MCE-family protein YP_002646602.1 3894281 R 561275 CDS YP_002646603.1 224991914 7564443 complement(3895333..3896535) 1 NC_012207.1 MCE-family protein 3896535 mce4A 7564443 mce4A Mycobacterium bovis BCG str. Tokyo 172 MCE-family protein YP_002646603.1 3895333 R 561275 CDS YP_002646604.1 224991915 7564442 complement(3896555..3897397) 1 NC_012207.1 hypothetical protein 3897397 yrbE4B 7564442 yrbE4B Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646604.1 3896555 R 561275 CDS YP_002646605.1 224991916 7561456 complement(3897432..3898196) 1 NC_012207.1 hypothetical protein 3898196 yrbE4A 7561456 yrbE4A Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646605.1 3897432 R 561275 CDS YP_002646606.1 224991917 7561455 complement(3898422..3899375) 1 NC_012207.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 3899375 fabG 7561455 fabG Mycobacterium bovis BCG str. Tokyo 172 3-ketoacyl-ACP reductase YP_002646606.1 3898422 R 561275 CDS YP_002646607.1 224991918 7562899 complement(3899400..3899591) 1 NC_012207.1 ferredoxin 3899591 fdxD 7562899 fdxD Mycobacterium bovis BCG str. Tokyo 172 ferredoxin YP_002646607.1 3899400 R 561275 CDS YP_002646608.1 224991919 7563409 3899806..3901008 1 NC_012207.1 acyl-CoA dehydrogenase 3901008 fadE26 7563409 fadE26 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002646608.1 3899806 D 561275 CDS YP_002646609.1 224991920 7563375 3901033..3902154 1 NC_012207.1 Differs from Rv3505 by 1aa V218A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; acyl-CoA dehydrogenase 3902154 fadE27 7563375 fadE27 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002646609.1 3901033 D 561275 CDS YP_002646610.1 224991921 7563376 3902225..3903733 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3903733 fadD17 7563376 fadD17 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002646610.1 3902225 D 561275 CDS YP_002646611.1 224991922 7562923 3903904..3908022 1 NC_012207.1 In Mycobacterium bovis, insertions of 18 bp, 72 bp and 9 bp (*-CGGCGGCAC), and deletions of 90 bp, 54 bp and 18 bp, and Mycobacterium bovis BCG Pasteur and BCG Tokyo, insertions of 18 bp, 81 bp and 9 bp (*-CGGCGGCAC), and deletions of 90 bp, 27 bp and 18 bp, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1360 aa and 1372 aa versus 1381 aa). Differs from Mb3537 by 2 insertions of 9aa and 3aa and by 1aa, N599D. Differs from Rv3507 by several insertions, deletions and by 2aa, N599D, G742D in BCG Pasteur. Differs from Mb3537 by 2 insertions of 9aa and 3aa in BCG Tokyo. Differs form Rv3507 by several insertions, deletions and by 1aa, G742D in BCG Tokyo.; PE-PGRS family protein 3908022 PE_PGRS53 7562923 PE_PGRS53 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002646611.1 3903904 D 561275 CDS YP_002646612.1 224991923 7562379 3908313..3914465 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur and BCG Tokyo, several insertions lead to a longer product compared to its homolog in Mycobacterium bovis (2094 aa in BCG Pasteur and 2055 aa in BCG Tokyo versus 1460 aa). The PE_PGRS54 gene of BCG Tokyo (6153bp) is 132bp shorter than that of BCG Pasteur (6285bp). There are two repeats of 465bp in BCG Tokyo and one such repeat in BCG Pasteur, as well as three repeats of 552bp in BCG Tokyo and four repeats in BCG Pasteur.; PE-PGRS family protein 3914465 PE_PGRS54 7562379 PE_PGRS54 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002646612.1 3908313 D 561275 CDS YP_002646613.1 224991924 7562380 complement(3914632..3916179) 1 NC_012207.1 thiamine-pyrophosphate requiring enzyme; hypothetical protein 3916179 ilvX 7562380 ilvX Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646613.1 3914632 R 561275 CDS YP_002646614.1 224991925 7562783 complement(3916176..3917012) 1 NC_012207.1 hypothetical protein 3917012 7562783 JTY_3574 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646614.1 3916176 R 561275 CDS YP_002646615.1 224991926 7564058 3917372..3922459 1 NC_012207.1 In Mycobacterium tuberculosis H37Rv, PE_PGRS55 and PE_PGRS56 exist as 2 genes. In Mycobacterium bovis, a 344bp insertion results in a single product which is more similar to PE_PGRS55. In Mycobacterium bovis BCG Pasteur and BCG Tokyo two deletions of 138bp and 246bp lead to a shorter product in BCG Pasteur compared to its homolog Mycobacterium bovis (1810 aa versus 1938 aa). Also differs from Mb3541 by 3aa, D628A, D743A and D857A. In BCG Tokyo, the PE_PGRS55 gene (5088bp, 1695aa) is 345bp shorter than that of BCG Pasteur (5433bp). As 345bp is the length of a repeat in the gene, the difference reflected the copy number of both BCG strains.; PE-PGRS family protein 3922459 PE_PGRS55 7564058 PE_PGRS55 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002646615.1 3917372 D 561275 CDS YP_002646616.1 224991927 7562381 complement(3922588..3923244) 1 NC_012207.1 fatty-acid-CoA ligase 3923244 fadD18 7562381 fadD18 Mycobacterium bovis BCG str. Tokyo 172 fatty-acid-CoA ligase YP_002646616.1 3922588 R 561275 CDS YP_002646617.1 224991928 7562924 3923290..3925359 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a deletion of 111 bp and an insertion of 360 bp (361bp in BCG Tokyo) lead to a longer product compared to its homolog Mycobacterium bovis (2094aa versus 1460aa). Also differs from Mb3543 by 2aa, S80L and T93A in BCG Pasteur. In BCG Tokyo, a deletion of 117 bp and an insertion of 345 bp, 2bp, and T, A, insertions after 1958:G, 1970:C of BCG Pasteur (BCG_3577), and 1bp, G, deletion at 1963:G of BCG Pasteur (BCG_3577), lead to two products, 689aa and 284aa. Also differs from Mb3543 by 2aa, S80L and T93A in BCG Tokyo.; PE-PGRS family protein 3925359 PE_PGRS57 7562924 PE_PGRS57 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002646617.1 3923290 D 561275 CDS YP_002646618.1 224991929 7562382 3925664..3926518 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur a deletion of 111 bp and an insertion of 360 bp lead to a longer product compared to its homolog Mycobacterium bovis (2094aa versus 1460aa). Also differs from Mb3543 by 2aa, S80L and T93A. In BCG Tokyo, 2bp, T, A, insertions after 1958:G and 1970:C of BCG Pasteur (BCG_3577), 1bp, G, deletion at 1963:G of BCG_3577. The PE_PGRS57 of BCG Tokyo divided into 2 parts, 689aa and 284aa.; PE-PGRS family protein 3926518 PE_PGRS57 7562382 PE_PGRS57 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002646618.1 3925664 D 561275 CDS YP_002646619.1 224991930 7562383 complement(3927079..3928725) 1 NC_012207.1 activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence; acyl-CoA synthetase 3928725 fadD19 7562383 fadD19 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002646619.1 3927079 R 561275 CDS YP_002646620.1 224991931 7562925 3928799..3929590 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 3929590 echA19 7562925 echA19 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002646620.1 3928799 D 561275 CDS YP_002646621.1 224991932 7561530 3929686..3930525 1 NC_012207.1 hypothetical protein 3930525 7561530 JTY_3581 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646621.1 3929686 D 561275 CDS YP_002646622.1 224991933 7564059 complement(3930580..3931161) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, cyp142 exists as a single gene. In Mycobacterium bovis, BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*) splits cyp142 into 2 parts,cyp142a and cyp142b; cytochrome P450 monooxygenase 142 3931161 cyp142b 7564059 cyp142b Mycobacterium bovis BCG str. Tokyo 172 cytochrome P450 monooxygenase 142 YP_002646622.1 3930580 R 561275 CDS YP_002646623.1 224991934 7563168 complement(3931158..3931775) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, cyp142 exists as a single gene. In Mycobacterium bovis, BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*) splits cyp142 into 2 parts, cyp142a and cyp142b; cytochrome P450 monooxygenase 142 3931775 cyp142a 7563168 cyp142a Mycobacterium bovis BCG str. Tokyo 172 cytochrome P450 monooxygenase 142 YP_002646623.1 3931158 R 561275 CDS YP_002646624.1 224991935 7563167 3931804..3932514 1 NC_012207.1 hypothetical protein 3932514 7563167 JTY_3584 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646624.1 3931804 D 561275 CDS YP_002646625.1 224991936 7564060 complement(3932579..3933622) 1 NC_012207.1 coenzyme F420-dependent oxidoreductase 3933622 7564060 JTY_3585 Mycobacterium bovis BCG str. Tokyo 172 coenzyme F420-dependent oxidoreductase YP_002646625.1 3932579 R 561275 CDS YP_002646626.1 224991937 7564061 3933775..3934686 1 NC_012207.1 Differs from Rv3521 by 1aa D295N in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3934686 7564061 JTY_3586 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646626.1 3933775 D 561275 CDS YP_002646627.1 224991938 7564062 3934702..3935766 1 NC_012207.1 Differs from Rv3522 by 1aa I324T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipid-transfer protein 3935766 7564062 JTY_3587 Mycobacterium bovis BCG str. Tokyo 172 lipid-transfer protein YP_002646627.1 3934702 D 561275 CDS YP_002646628.1 224991939 7564063 3935783..3936967 1 NC_012207.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 3936967 7564063 JTY_3588 Mycobacterium bovis BCG str. Tokyo 172 acetyl-CoA acetyltransferase YP_002646628.1 3935783 D 561275 CDS YP_002646629.1 224991940 7564064 3937009..3938040 1 NC_012207.1 hypothetical protein 3938040 7564064 JTY_3589 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646629.1 3937009 D 561275 CDS YP_002646630.1 224991941 7564065 complement(3938054..3938578) 1 NC_012207.1 siderophore-binding protein 3938578 7564065 JTY_3590 Mycobacterium bovis BCG str. Tokyo 172 siderophore-binding protein YP_002646630.1 3938054 R 561275 CDS YP_002646631.1 224991942 7564066 3938693..3939853 1 NC_012207.1 oxidoreductase 3939853 7564066 JTY_3591 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646631.1 3938693 D 561275 CDS YP_002646632.1 224991943 7564067 3939859..3940308 1 NC_012207.1 hypothetical protein 3940308 7564067 JTY_3592 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646632.1 3939859 D 561275 CDS YP_002646633.1 224991944 7564068 complement(3940733..3941446) 1 NC_012207.1 hypothetical protein 3941446 7564068 JTY_3593 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646633.1 3940733 R 561275 CDS YP_002646634.1 224991945 7564069 complement(3942138..3943292) 1 NC_012207.1 hypothetical protein 3943292 7564069 JTY_3594 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646634.1 3942138 R 561275 CDS YP_002646635.1 224991946 7564070 complement(3943292..3944074) 1 NC_012207.1 short chain dehydrogenase 3944074 7564070 JTY_3595 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002646635.1 3943292 R 561275 CDS YP_002646636.1 224991947 7564071 complement(3944071..3945198) 1 NC_012207.1 hypothetical protein 3945198 7564071 JTY_3596 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646636.1 3944071 R 561275 CDS YP_002646637.1 224991948 7564072 3945597..3946817 1 NC_012207.1 PPE family protein 3946817 PPE61 7564072 PPE61 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002646637.1 3945597 D 561275 CDS YP_002646638.1 224991949 7560795 complement(3946959..3948707) 1 NC_012207.1 PPE family protein 3948707 PPE62 7560795 PPE62 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002646638.1 3946959 R 561275 CDS YP_002646639.1 224991950 7560796 complement(3948806..3949846) 1 NC_012207.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 3949846 7560796 JTY_3599 Mycobacterium bovis BCG str. Tokyo 172 4-hydroxy-2-ketovalerate aldolase YP_002646639.1 3948806 R 561275 CDS YP_002646640.1 224991951 7564073 complement(3949843..3950754) 1 NC_012207.1 catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 3950754 7564073 JTY_3600 Mycobacterium bovis BCG str. Tokyo 172 acetaldehyde dehydrogenase YP_002646640.1 3949843 R 561275 CDS YP_002646641.1 224991952 7564074 complement(3950765..3951550) 1 NC_012207.1 hydratase 3951550 7564074 JTY_3601 Mycobacterium bovis BCG str. Tokyo 172 hydratase YP_002646641.1 3950765 R 561275 CDS YP_002646642.1 224991953 7564075 3951623..3953314 1 NC_012207.1 initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione; 3-ketosteroid-delta-1-dehydrogenase 3953314 7564075 JTY_3602 Mycobacterium bovis BCG str. Tokyo 172 3-ketosteroid-delta-1-dehydrogenase YP_002646642.1 3951623 D 561275 CDS YP_002646643.1 224991954 7564076 3953316..3954176 1 NC_012207.1 dehydrogenase 3954176 7564076 JTY_3603 Mycobacterium bovis BCG str. Tokyo 172 dehydrogenase YP_002646643.1 3953316 D 561275 CDS YP_002646644.1 224991955 7564077 3954313..3955752 1 NC_012207.1 PPE family protein 3955752 PPE63 7564077 PPE63 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002646644.1 3954313 D 561275 CDS YP_002646645.1 224991956 7560797 complement(3955753..3956913) 1 NC_012207.1 lipid-transfer protein 3956913 ltp2 7560797 ltp2 Mycobacterium bovis BCG str. Tokyo 172 lipid-transfer protein YP_002646645.1 3955753 R 561275 CDS YP_002646646.1 224991957 7560539 complement(3956913..3957302) 1 NC_012207.1 hypothetical protein 3957302 7560539 JTY_3606 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646646.1 3956913 R 561275 CDS YP_002646647.1 224991958 7564078 complement(3957299..3958234) 1 NC_012207.1 hypothetical protein 3958234 7564078 JTY_3607 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646647.1 3957299 R 561275 CDS YP_002646648.1 224991959 7564079 complement(3958231..3959394) 1 NC_012207.1 acyl-CoA dehydrogenase 3959394 fadE29 7564079 fadE29 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002646648.1 3958231 R 561275 CDS YP_002646649.1 224991960 7563378 complement(3959379..3960398) 1 NC_012207.1 acyl-CoA dehydrogenase 3960398 fadE28 7563378 fadE28 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002646649.1 3959379 R 561275 CDS YP_002646650.1 224991961 7563377 complement(3960398..3961699) 1 NC_012207.1 cytochrome P450 125 3961699 cyp125 7563377 cyp125 Mycobacterium bovis BCG str. Tokyo 172 cytochrome P450 125 YP_002646650.1 3960398 R 561275 CDS YP_002646651.1 224991962 7563156 3961811..3962986 1 NC_012207.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 3962986 fadA5 7563156 fadA5 Mycobacterium bovis BCG str. Tokyo 172 acetyl-CoA acetyltransferase YP_002646651.1 3961811 D 561275 CDS YP_002646652.1 224991963 7562908 3963098..3963553 1 NC_012207.1 hypothetical protein 3963553 7562908 JTY_3612 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646652.1 3963098 D 561275 CDS YP_002646653.1 224991964 7564080 complement(3963636..3964550) 1 NC_012207.1 Differs from Rv3548c by 1aa V218M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; short chain dehydrogenase 3964550 7564080 JTY_3613 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002646653.1 3963636 R 561275 CDS YP_002646654.1 224991965 7564081 complement(3964573..3965352) 1 NC_012207.1 short chain dehydrogenase 3965352 7564081 JTY_3614 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002646654.1 3964573 R 561275 CDS YP_002646655.1 224991966 7564082 3965407..3966150 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 3966150 echA20 7564082 echA20 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002646655.1 3965407 D 561275 CDS YP_002646656.1 224991967 7561532 3966150..3967028 1 NC_012207.1 Differs from Rv3551 by 1aa, S7A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; CoA-transferase subunit alpha 3967028 7561532 JTY_3616 Mycobacterium bovis BCG str. Tokyo 172 CoA-transferase subunit alpha YP_002646656.1 3966150 D 561275 CDS YP_002646657.1 224991968 7564083 3967025..3967777 1 NC_012207.1 CoA-transferase subunit beta 3967777 7564083 JTY_3617 Mycobacterium bovis BCG str. Tokyo 172 CoA-transferase subunit beta YP_002646657.1 3967025 D 561275 CDS YP_002646658.1 224991969 7564084 3967875..3968942 1 NC_012207.1 oxidoreductase 3968942 7564084 JTY_3618 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646658.1 3967875 D 561275 CDS YP_002646659.1 224991970 7564085 3968939..3970996 1 NC_012207.1 electron transfer protein 3970996 fdxB 7564085 fdxB Mycobacterium bovis BCG str. Tokyo 172 electron transfer protein YP_002646659.1 3968939 D 561275 CDS YP_002646660.1 224991971 7563407 complement(3971084..3971953) 1 NC_012207.1 Differs from Rv3555c by 1aa R268W in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3971953 7563407 JTY_3620 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646660.1 3971084 R 561275 CDS YP_002646661.1 224991972 7564168 complement(3972058..3973218) 1 NC_012207.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 3973218 fadA6 7564168 fadA6 Mycobacterium bovis BCG str. Tokyo 172 acetyl-CoA acetyltransferase YP_002646661.1 3972058 R 561275 CDS YP_002646662.1 224991973 7562909 complement(3973283..3973885) 1 NC_012207.1 probably TetR-family; transcriptional regulatory protein 3973885 7562909 JTY_3622 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646662.1 3973283 R 561275 CDS YP_002646663.1 224991974 7563676 3974234..3975892 1 NC_012207.1 PPE family protein 3975892 PPE64 7563676 PPE64 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002646663.1 3974234 D 561275 CDS YP_002646664.1 224991975 7560798 complement(3975901..3976689) 1 NC_012207.1 Differs from Rv3559c by 1aa V222A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; short chain dehydrogenase 3976689 7560798 JTY_3624 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002646664.1 3975901 R 561275 CDS YP_002646665.1 224991976 7563677 complement(3976686..3977843) 1 NC_012207.1 acyl-CoA dehydrogenase 3977843 fadE30 7563677 fadE30 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002646665.1 3976686 R 561275 CDS YP_002646666.1 224991977 7563380 3977891..3979414 1 NC_012207.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 3979414 fadD3 7563380 fadD3 Mycobacterium bovis BCG str. Tokyo 172 long-chain-fatty-acid--CoA ligase YP_002646666.1 3977891 D 561275 CDS YP_002646667.1 224991978 7562935 3979415..3980548 1 NC_012207.1 acyl-CoA dehydrogenase 3980548 fadE31 7562935 fadE31 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002646667.1 3979415 D 561275 CDS YP_002646668.1 224991979 7563381 3980545..3981504 1 NC_012207.1 Differs from Rv3563 by 2aa R105Q and S275W in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acyl-CoA dehydrogenase 3981504 fadE32 7563381 fadE32 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002646668.1 3980545 D 561275 CDS YP_002646669.1 224991980 7563382 3981501..3982457 1 NC_012207.1 acyl-CoA dehydrogenase 3982457 fadE33 7563382 fadE33 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002646669.1 3981501 D 561275 CDS YP_002646670.1 224991981 7563383 3982454..3983620 1 NC_012207.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 3983620 aspB 7563383 aspB Mycobacterium bovis BCG str. Tokyo 172 aspartate aminotransferase YP_002646670.1 3982454 D 561275 CDS YP_002646671.1 224991982 7562043 complement(3983585..3984436) 1 NC_012207.1 arylamine N-acetyltransferase 3984436 nat 7562043 nat Mycobacterium bovis BCG str. Tokyo 172 arylamine N-acetyltransferase YP_002646671.1 3983585 R 561275 CDS YP_002646672.1 224991983 7562455 complement(3984421..3984687) 1 NC_012207.1 hypothetical protein 3984687 7562455 JTY_3632 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646672.1 3984421 R 561275 CDS YP_002646673.1 224991984 7563678 complement(3984973..3985536) 1 NC_012207.1 Differs from Rv3567c by 1aa T179I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 3985536 7563678 JTY_3633 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646673.1 3984973 R 561275 CDS YP_002646674.1 224991985 7563679 complement(3985551..3986453) 1 NC_012207.1 Differs from Mb3599c by 1aa Q177R in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; biphenyl-2,3-diol 1,2-dioxygenase 3986453 bphC 7563679 bphC Mycobacterium bovis BCG str. Tokyo 172 biphenyl-2,3-diol 1,2-dioxygenase YP_002646674.1 3985551 R 561275 CDS YP_002646675.1 224991986 7562074 complement(3986450..3987325) 1 NC_012207.1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase 3987325 bphD 7562074 bphD Mycobacterium bovis BCG str. Tokyo 172 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase YP_002646675.1 3986450 R 561275 CDS YP_002646676.1 224991987 7562075 complement(3987340..3988524) 1 NC_012207.1 Differs from Rv3570c by 1aa D18N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 3988524 7562075 JTY_3636 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646676.1 3987340 R 561275 CDS YP_002646677.1 224991988 7563680 3988671..3989747 1 NC_012207.1 hemoglobine-related protein 3989747 hmp 7563680 hmp Mycobacterium bovis BCG str. Tokyo 172 hemoglobine-related protein YP_002646677.1 3988671 D 561275 CDS YP_002646678.1 224991989 7563320 3989765..3990295 1 NC_012207.1 hypothetical protein 3990295 7563320 JTY_3638 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646678.1 3989765 D 561275 CDS YP_002646679.1 224991990 7563681 complement(3990331..3992466) 1 NC_012207.1 acyl-CoA dehydrogenase 3992466 fadE34 7563681 fadE34 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002646679.1 3990331 R 561275 CDS YP_002646680.1 224991991 7563384 3992738..3993337 1 NC_012207.1 probably TetR-family; transcriptional regulatory protein 3993337 7563384 JTY_3640 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646680.1 3992738 D 561275 CDS YP_002646681.1 224991992 7563682 complement(3993343..3994422) 1 NC_012207.1 probably LacI-family; transcriptional regulatory protein 3994422 7563682 JTY_3641 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646681.1 3993343 R 561275 CDS YP_002646682.1 224991993 7563683 3994612..3995325 1 NC_012207.1 Differs from Rv3576 by 1aa N118D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 3995325 lppH 7563683 lppH Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002646682.1 3994612 D 561275 CDS YP_002646683.1 224991994 7560473 3995516..3996382 1 NC_012207.1 hypothetical protein 3996382 7560473 JTY_3643 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646683.1 3995516 D 561275 CDS YP_002646684.1 224991995 7563684 3996396..3997637 1 NC_012207.1 Differs from Rv3578 by 1aa S319A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; arsenical pump integral membrane protein 3997637 arsB2 7563684 arsB2 Mycobacterium bovis BCG str. Tokyo 172 arsenical pump integral membrane protein YP_002646684.1 3996396 D 561275 CDS YP_002646685.1 224991996 7562037 complement(3997679..3998647) 1 NC_012207.1 Differs from Rv3579c by 1aa , A302E in Mycobacterium bovis BCG Pasteur and BCG Tokyo. Mb3610c is longer due to frameshift and differs by 1aa V178M in Mycobacterium bovis.; tRNA/rRNA methyltransferase 3998647 7562037 JTY_3645 Mycobacterium bovis BCG str. Tokyo 172 tRNA/rRNA methyltransferase YP_002646685.1 3997679 R 561275 CDS YP_002646686.1 224991997 7563685 complement(3998648..4000057) 1 NC_012207.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 4000057 cysS 7563685 cysS Mycobacterium bovis BCG str. Tokyo 172 cysteinyl-tRNA synthetase YP_002646686.1 3998648 R 561275 CDS YP_002646687.1 224991998 7563183 complement(4000122..4000601) 1 NC_012207.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4000601 ispF 7563183 ispF Mycobacterium bovis BCG str. Tokyo 172 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_002646687.1 4000122 R 561275 CDS YP_002646688.1 224991999 7562796 complement(4000598..4001293) 1 NC_012207.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 4001293 ispD 7562796 ispD Mycobacterium bovis BCG str. Tokyo 172 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_002646688.1 4000598 R 561275 CDS YP_002646689.1 224992000 7562794 complement(4001310..4001798) 1 NC_012207.1 Differs from Rv3583 by 1 aa, R13H in BCG Tokyo.; transcription factor 4001798 7562794 JTY_3649 Mycobacterium bovis BCG str. Tokyo 172 transcription factor YP_002646689.1 4001310 R 561275 CDS YP_002646690.1 224992001 7563686 4002083..4002631 1 NC_012207.1 lipoprotein 4002631 lpqE 7563686 lpqE Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002646690.1 4002083 D 561275 CDS YP_002646691.1 224992002 7560497 4002697..4004139 1 NC_012207.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 4004139 radA 7560497 radA Mycobacterium bovis BCG str. Tokyo 172 DNA repair protein RadA YP_002646691.1 4002697 D 561275 CDS YP_002646692.1 224992003 7561549 4004144..4005220 1 NC_012207.1 non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair; DNA integrity scanning protein DisA 4005220 7561549 JTY_3652 Mycobacterium bovis BCG str. Tokyo 172 DNA integrity scanning protein DisA YP_002646692.1 4004144 D 561275 CDS YP_002646693.1 224992004 7563687 complement(4005221..4006012) 1 NC_012207.1 Shorter than Rv3587c and Mb3618c by 1aa, P at 240 in BCG Pasteur and BCG Tokyo; hypothetical protein 4006012 7563687 JTY_3653 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646693.1 4005221 R 561275 CDS YP_002646694.1 224992005 7563688 complement(4006121..4006744) 1 NC_012207.1 Differs from Mb3619c by 1aa I79T in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; carbonic anhydrase 4006744 canB 7563688 canB Mycobacterium bovis BCG str. Tokyo 172 carbonic anhydrase YP_002646694.1 4006121 R 561275 CDS YP_002646695.1 224992006 7562081 4006743..4007657 1 NC_012207.1 adenine glycosylase 4007657 mutY 7562081 mutY Mycobacterium bovis BCG str. Tokyo 172 adenine glycosylase YP_002646695.1 4006743 D 561275 CDS YP_002646696.1 224992007 7563584 complement(4007654..4009408) 1 NC_012207.1 PE-PGRS family protein 4009408 PE_PGRS58 7563584 PE_PGRS58 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002646696.1 4007654 R 561275 CDS YP_002646697.1 224992008 7562384 complement(4009519..4010292) 1 NC_012207.1 hydrolase 4010292 7562384 JTY_3657 Mycobacterium bovis BCG str. Tokyo 172 hydrolase YP_002646697.1 4009519 R 561275 CDS YP_002646698.1 224992009 7563689 4010307..4010624 1 NC_012207.1 hypothetical protein 4010624 TB11.2 7563689 TB11.2 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646698.1 4010307 D 561275 CDS YP_002646699.1 224992010 7561827 4010602..4011960 1 NC_012207.1 Differs from Rv3593 by 2 aa, V159A, S186N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 4011960 lpqF 7561827 lpqF Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002646699.1 4010602 D 561275 CDS YP_002646700.1 224992011 7560498 4012107..4012934 1 NC_012207.1 hypothetical protein 4012934 7560498 JTY_3660 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646700.1 4012107 D 561275 CDS YP_002646701.1 224992012 7563690 complement(4012848..4014326) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base deletion (a-*) and a 27bp insertion (*-GCGCGCCGGGGCCACCGTTTCCGCCGG), lead to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (492 aa versus 439 aa); PE-PGRS family protein 4014326 PE_PGRS59 7563690 PE_PGRS59 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002646701.1 4012848 R 561275 CDS YP_002646702.1 224992013 7562385 complement(4014434..4016980) 1 NC_012207.1 ATP-dependent Clp protease ATP-binding subunit 4016980 clpC 7562385 clpC Mycobacterium bovis BCG str. Tokyo 172 ATP-dependent Clp protease ATP-binding subunit YP_002646702.1 4014434 R 561275 CDS YP_002646703.1 224992014 7562108 complement(4017257..4017595) 1 NC_012207.1 lsr2 protein precursor 4017595 lsr2 7562108 lsr2 Mycobacterium bovis BCG str. Tokyo 172 lsr2 protein precursor YP_002646703.1 4017257 R 561275 CDS YP_002646704.1 224992015 7560537 complement(4017699..4019216) 1 NC_012207.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 4019216 lysS 7560537 lysS Mycobacterium bovis BCG str. Tokyo 172 lysyl-tRNA synthetase YP_002646704.1 4017699 R 561275 CDS YP_002646705.1 224992016 7560542 complement(4019317..4020135) 1 NC_012207.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 4020135 7560542 JTY_3665 Mycobacterium bovis BCG str. Tokyo 172 pantothenate kinase YP_002646705.1 4019317 R 561275 CDS YP_002646706.1 224992017 7563691 complement(4020138..4020557) 1 NC_012207.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 4020557 panD 7563691 panD Mycobacterium bovis BCG str. Tokyo 172 aspartate alpha-decarboxylase YP_002646706.1 4020138 R 561275 CDS YP_002646707.1 224992018 7562510 complement(4020557..4021486) 1 NC_012207.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 4021486 panC 7562510 panC Mycobacterium bovis BCG str. Tokyo 172 pantoate--beta-alanine ligase YP_002646707.1 4020557 R 561275 CDS YP_002646708.1 224992019 7562509 complement(4021483..4022394) 1 NC_012207.1 hypothetical alanine and leucine rich protein 4022394 7562509 JTY_3668 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine and leucine rich protein YP_002646708.1 4021483 R 561275 CDS YP_002646709.1 224992020 7563692 complement(4022579..4023772) 1 NC_012207.1 Differs from Rv3604c by G153V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein rich in alanine and arginine and proline 4023772 7563692 JTY_3669 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein rich in alanine and arginine and proline YP_002646709.1 4022579 R 561275 CDS YP_002646710.1 224992021 7563693 complement(4023981..4024457) 1 NC_012207.1 hypothetical protein 4024457 7563693 JTY_3670 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646710.1 4023981 R 561275 CDS YP_002646711.1 224992022 7563694 complement(4024457..4025023) 1 NC_012207.1 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 4025023 folK 7563694 folK Mycobacterium bovis BCG str. Tokyo 172 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_002646711.1 4024457 R 561275 CDS YP_002646712.1 224992023 7563423 complement(4025020..4025421) 1 NC_012207.1 dihydroneopterin aldolase 4025421 folB 7563423 folB Mycobacterium bovis BCG str. Tokyo 172 dihydroneopterin aldolase YP_002646712.1 4025020 R 561275 CDS YP_002646713.1 224992024 7563419 complement(4025414..4026256) 1 NC_012207.1 dihydropteroate synthase 1 4026256 folP1 7563419 folP1 Mycobacterium bovis BCG str. Tokyo 172 dihydropteroate synthase 1 YP_002646713.1 4025414 R 561275 CDS YP_002646714.1 224992025 7563424 complement(4026253..4026861) 1 NC_012207.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 4026861 folE 7563424 folE Mycobacterium bovis BCG str. Tokyo 172 GTP cyclohydrolase I YP_002646714.1 4026253 R 561275 CDS YP_002646715.1 224992026 7563422 complement(4026877..4029159) 1 NC_012207.1 membrane-bound protease 4029159 ftsH 7563422 ftsH Mycobacterium bovis BCG str. Tokyo 172 membrane-bound protease YP_002646715.1 4026877 R 561275 CDS YP_002646716.1 224992027 7561877 4029226..4029768 1 NC_012207.1 Identical to Rv3611 in BCG Pasteur. In Mycobacterium bovis and BCG Tokyo, a 111bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis (180 aa versus 217aa).; hypothetical arginine and proline rich protein 4029768 7561877 JTY_3676 Mycobacterium bovis BCG str. Tokyo 172 hypothetical arginine and proline rich protein YP_002646716.1 4029226 D 561275 CDS YP_002646717.1 224992028 7563695 complement(4029683..4030012) 1 NC_012207.1 hypothetical protein 4030012 7563695 JTY_3677 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646717.1 4029683 R 561275 CDS YP_002646718.1 224992029 7563696 complement(4030046..4030207) 1 NC_012207.1 hypothetical protein 4030207 7563696 JTY_3678 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646718.1 4030046 R 561275 CDS YP_002646719.1 224992030 7563697 complement(4030307..4030861) 1 NC_012207.1 hypothetical protein 4030861 7563697 JTY_3679 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646719.1 4030307 R 561275 CDS YP_002646720.1 224992031 7563698 complement(4030977..4031288) 1 NC_012207.1 hypothetical protein 4031288 7563698 JTY_3680 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646720.1 4030977 R 561275 CDS YP_002646721.1 224992032 7563699 complement(4031362..4032540) 1 NC_012207.1 Differs from Rv3616c by 2aa, V4A, I192T and Mb3646c by 2aa, V4A, V153A in BCG Pasteur and BCG Tokyo; hypothetical alanine and glycine rich protein 4032540 7563699 JTY_3681 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine and glycine rich protein YP_002646721.1 4031362 R 561275 CDS YP_002646722.1 224992033 7563700 4033006..4033521 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 5894 bp deletion (RD8) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (171 aa versus 240 aa); lipoprotein 4033521 lpqG 7563700 lpqG Mycobacterium bovis BCG str. Tokyo 172 lipoprotein YP_002646722.1 4033006 D 561275 CDS YP_002646723.1 224992034 7560499 complement(4033526..4034176) 1 NC_012207.1 Differs by 2 aa from Rv3624c et Mb3648c A111T, N122D in Mycobacterium bovis BCG Pasteur. Differs by 1 aa from Rv3624c et Mb3648c A111T in Mycobacterium bovis BCG Tokyo.; hypoxanthine-guanine phosphoribosyltransferase 4034176 hpt 7560499 hpt Mycobacterium bovis BCG str. Tokyo 172 hypoxanthine-guanine phosphoribosyltransferase YP_002646723.1 4033526 R 561275 CDS YP_002646724.1 224992035 7563322 complement(4034173..4035144) 1 NC_012207.1 cell cycle protein 4035144 mesJ 7563322 mesJ Mycobacterium bovis BCG str. Tokyo 172 cell cycle protein YP_002646724.1 4034173 R 561275 CDS YP_002646725.1 224992036 7564455 complement(4035123..4036175) 1 NC_012207.1 hypothetical protein 4036175 7564455 JTY_3685 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646725.1 4035123 R 561275 CDS YP_002646726.1 224992037 7563701 complement(4036172..4037557) 1 NC_012207.1 Differs from Rv3627c by 2 aa, V45A, V81A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4037557 7563701 JTY_3686 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646726.1 4036172 R 561275 CDS YP_002646727.1 224992038 7563702 4037695..4038183 1 NC_012207.1 inorganic pyrophosphatase 4038183 ppa 7563702 ppa Mycobacterium bovis BCG str. Tokyo 172 inorganic pyrophosphatase YP_002646727.1 4037695 D 561275 CDS YP_002646728.1 224992039 7562142 complement(4038229..4039326) 1 NC_012207.1 hypothetical protein 4039326 7562142 JTY_3688 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646728.1 4038229 R 561275 CDS YP_002646729.1 224992040 7563703 4039447..4040742 1 NC_012207.1 Differs from Rv3630 by 1aa, T40A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein 4040742 7563703 JTY_3689 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002646729.1 4039447 D 561275 CDS YP_002646730.1 224992041 7563704 4040786..4041511 1 NC_012207.1 possibly glycosyltransferase; transferase 4041511 7563704 JTY_3690 Mycobacterium bovis BCG str. Tokyo 172 transferase YP_002646730.1 4040786 D 561275 CDS YP_002646731.1 224992042 7563705 4041508..4041852 1 NC_012207.1 hypothetical protein 4041852 7563705 JTY_3691 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646731.1 4041508 D 561275 CDS YP_002646732.1 224992043 7563706 4042063..4042938 1 NC_012207.1 hypothetical protein 4042938 7563706 JTY_3692 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646732.1 4042063 D 561275 CDS YP_002646733.1 224992044 7563707 complement(4042939..4043883) 1 NC_012207.1 UDP-glucose 4-epimerase 4043883 galE1 7563707 galE1 Mycobacterium bovis BCG str. Tokyo 172 UDP-glucose 4-epimerase YP_002646733.1 4042939 R 561275 CDS YP_002646734.1 224992045 7561896 4043906..4045681 1 NC_012207.1 transmembrane protein 4045681 7561896 JTY_3694 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646734.1 4043906 D 561275 CDS YP_002646735.1 224992046 7563708 4046024..4046371 1 NC_012207.1 transposase 4046371 7563708 JTY_3695 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646735.1 4046024 D 561275 CDS YP_002646736.1 224992047 7563709 4046756..4047256 1 NC_012207.1 transposase 4047256 7563709 JTY_3696 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646736.1 4046756 D 561275 CDS YP_002646737.1 224992048 7563710 4047256..4048002 1 NC_012207.1 transposase 4048002 7563710 JTY_3697 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646737.1 4047256 D 561275 CDS YP_002646738.1 224992049 7563711 complement(4048156..4048722) 1 NC_012207.1 Differs from Rv3639c by 1 aa, N53K in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 4048722 7563711 JTY_3698 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646738.1 4048156 R 561275 CDS YP_002646739.1 224992050 7563712 complement(4048792..4050021) 1 NC_012207.1 Differs from Rv3640c by 1aa, E296G in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; transposase 4050021 7563712 JTY_3699 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646739.1 4048792 R 561275 CDS YP_002646740.1 224992051 7563713 complement(4050197..4050832) 1 NC_012207.1 cell filamentation protein 4050832 fic 7563713 fic Mycobacterium bovis BCG str. Tokyo 172 cell filamentation protein YP_002646740.1 4050197 R 561275 CDS YP_002646741.1 224992052 7563414 complement(4050843..4051037) 1 NC_012207.1 hypothetical protein 4051037 7563414 JTY_3701 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646741.1 4050843 R 561275 CDS YP_002646742.1 224992053 7563714 4051432..4051623 1 NC_012207.1 hypothetical protein 4051623 7563714 JTY_3702 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646742.1 4051432 D 561275 CDS YP_002646743.1 224992054 7561855 complement(4051788..4052993) 1 NC_012207.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 4052993 7561855 JTY_3703 Mycobacterium bovis BCG str. Tokyo 172 DNA polymerase III subunit delta' YP_002646743.1 4051788 R 561275 CDS YP_002646744.1 224992055 7563716 4053079..4054728 1 NC_012207.1 transmembrane protein 4054728 7563716 JTY_3704 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646744.1 4053079 D 561275 CDS YP_002646745.1 224992056 7563717 complement(4054725..4057529) 1 NC_012207.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 4057529 topA 7563717 topA Mycobacterium bovis BCG str. Tokyo 172 DNA topoisomerase I YP_002646745.1 4054725 R 561275 CDS YP_002646746.1 224992057 7561863 complement(4057882..4058460) 1 NC_012207.1 hypothetical protein 4058460 7561863 JTY_3706 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646746.1 4057882 R 561275 CDS YP_002646747.1 224992058 7563718 complement(4058600..4058803) 1 NC_012207.1 cold shock protein A 4058803 cspA 7563718 cspA Mycobacterium bovis BCG str. Tokyo 172 cold shock protein A YP_002646747.1 4058600 R 561275 CDS YP_002646748.1 224992059 7563124 4059053..4061368 1 NC_012207.1 Differs from Rv3649 by 2aa, P93L, D677G, and from Mb3673 by D677G in BCG Pasteur and BCG Tokyo; helicase 4061368 7563124 JTY_3708 Mycobacterium bovis BCG str. Tokyo 172 helicase YP_002646748.1 4059053 D 561275 CDS YP_002646749.1 224992060 7563719 4061505..4061789 1 NC_012207.1 PE family protein 4061789 PE33 7563719 PE33 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002646749.1 4061505 D 561275 CDS YP_002646750.1 224992061 7561732 4062113..4063150 1 NC_012207.1 hypothetical protein 4063150 7561732 JTY_3710 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646750.1 4062113 D 561275 CDS YP_002646751.1 224992062 7563720 4063904..4064218 1 NC_012207.1 PE-PGRS family protein 4064218 PE_PGRS60 7563720 PE_PGRS60 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002646751.1 4063904 D 561275 CDS YP_002646752.1 224992063 7562386 4064212..4064907 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, a frameshift due to an in-frame insertion of 126 bp leads to a longer product than in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo. Shorter than Mb3677 due to 18 bp in-frame deletion, removes 6 codons; PE-PGRS family protein 4064907 PE_PGRS61 7562386 PE_PGRS61 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002646752.1 4064212 D 561275 CDS YP_002646753.1 224992064 7562387 complement(4065024..4065278) 1 NC_012207.1 hypothetical protein 4065278 7562387 JTY_3713 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646753.1 4065024 R 561275 CDS YP_002646754.1 224992065 7563721 complement(4065364..4065663) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base deletion (c-*) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (99 aa versus 125 aa); hypothetical protein 4065663 7563721 JTY_3714 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646754.1 4065364 R 561275 CDS YP_002646755.1 224992066 7563722 complement(4065687..4065893) 1 NC_012207.1 hypothetical protein 4065893 7563722 JTY_3715 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646755.1 4065687 R 561275 CDS YP_002646756.1 224992067 7563723 complement(4065903..4066478) 1 NC_012207.1 alanine rich membrane protein 4066478 7563723 JTY_3716 Mycobacterium bovis BCG str. Tokyo 172 alanine rich membrane protein YP_002646756.1 4065903 R 561275 CDS YP_002646757.1 224992068 7563724 complement(4066502..4067302) 1 NC_012207.1 transmembrane protein 4067302 7563724 JTY_3717 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646757.1 4066502 R 561275 CDS YP_002646758.1 224992069 7563725 complement(4067299..4068357) 1 NC_012207.1 hypothetical protein 4068357 7563725 JTY_3718 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646758.1 4067299 R 561275 CDS YP_002646759.1 224992070 7563726 complement(4068459..4069511) 1 NC_012207.1 Differs from Rv3660c by 1aa, L30P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4069511 7563726 JTY_3719 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646759.1 4068459 R 561275 CDS YP_002646760.1 224992071 7563727 4070011..4070874 1 NC_012207.1 Differs from Rv3661 by 1aa, P40S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4070874 7563727 JTY_3720 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646760.1 4070011 D 561275 CDS YP_002646761.1 224992072 7563728 complement(4071629..4072399) 1 NC_012207.1 Differs from Rv3662c by 1aa, T34A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4072399 7563728 JTY_3721 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646761.1 4071629 R 561275 CDS YP_002646762.1 224992073 7563729 complement(4072396..4074042) 1 NC_012207.1 dipeptide-transport ATP-binding protein ABC transporter 4074042 dppD 7563729 dppD Mycobacterium bovis BCG str. Tokyo 172 dipeptide-transport ATP-binding protein ABC transporter YP_002646762.1 4072396 R 561275 CDS YP_002646763.1 224992074 7561513 complement(4074039..4074839) 1 NC_012207.1 dipeptide-transport integral membrane protein ABC transporter 4074839 dppC 7561513 dppC Mycobacterium bovis BCG str. Tokyo 172 dipeptide-transport integral membrane protein ABC transporter YP_002646763.1 4074039 R 561275 CDS YP_002646764.1 224992075 7561512 complement(4074895..4075821) 1 NC_012207.1 dipeptide-transport integral membrane protein ABC transporter 4075821 dppB 7561512 dppB Mycobacterium bovis BCG str. Tokyo 172 dipeptide-transport integral membrane protein ABC transporter YP_002646764.1 4074895 R 561275 CDS YP_002646765.1 224992076 7561511 complement(4075823..4077448) 1 NC_012207.1 Differs from Rv3666c by 2aa, R4Q, Q443R and to Mb3690c by 1aa, E451G in BCG Pasteur and BCG Tokyo; periplasmic dipeptide-binding lipoprotein 4077448 dppA 7561511 dppA Mycobacterium bovis BCG str. Tokyo 172 periplasmic dipeptide-binding lipoprotein YP_002646765.1 4075823 R 561275 CDS YP_002646766.1 224992077 7563935 complement(4080146..4080844) 1 NC_012207.1 protease 4080844 7563935 JTY_3727 Mycobacterium bovis BCG str. Tokyo 172 protease YP_002646766.1 4080146 R 561275 CDS YP_002646767.1 224992078 7563730 4081190..4081708 1 NC_012207.1 transmembrane protein 4081708 7563730 JTY_3728 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646767.1 4081190 D 561275 CDS YP_002646768.1 224992079 7563731 4081709..4082692 1 NC_012207.1 epoxide hydrolase 4082692 ephE 7563731 ephE Mycobacterium bovis BCG str. Tokyo 172 epoxide hydrolase YP_002646768.1 4081709 D 561275 CDS YP_002646769.1 224992080 7562870 complement(4082685..4083878) 1 NC_012207.1 Differs from Rv3671c by 3aa, T165N, L359F, V363I and from Mb3695c by 3aa, T165N and L359F in BCG Pasteur and BCG Tokyo; membrane-associated serine protease 4083878 7562870 JTY_3730 Mycobacterium bovis BCG str. Tokyo 172 membrane-associated serine protease YP_002646769.1 4082685 R 561275 CDS YP_002646770.1 224992081 7563732 complement(4083884..4084705) 1 NC_012207.1 hypothetical protein 4084705 7563732 JTY_3731 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646770.1 4083884 R 561275 CDS YP_002646771.1 224992082 7563733 complement(4084837..4085520) 1 NC_012207.1 membrane-anchored thioredoxin-like protein 4085520 7563733 JTY_3732 Mycobacterium bovis BCG str. Tokyo 172 membrane-anchored thioredoxin-like protein YP_002646771.1 4084837 R 561275 CDS YP_002646772.1 224992083 7563734 complement(4085520..4086257) 1 NC_012207.1 endonuclease III 4086257 nth 7563734 nth Mycobacterium bovis BCG str. Tokyo 172 endonuclease III YP_002646772.1 4085520 R 561275 CDS YP_002646773.1 224992084 7562472 4086365..4086742 1 NC_012207.1 hypothetical protein 4086742 7562472 JTY_3734 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646773.1 4086365 D 561275 CDS YP_002646774.1 224992085 7563735 4086841..4087515 1 NC_012207.1 Differs from Rv3676 and Mb 3700 by 2aa, P47L, K178E in Mycobacterium bovis BCG Pasteur. Differs from Rv3676 and Mb3700 by 2aa, E178K, V184A in Mycobacterium bovis BCG Tokyo; probably crp/fnr-family; transcriptional regulatory protein 4087515 7563735 JTY_3735 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646774.1 4086841 D 561275 CDS YP_002646775.1 224992086 7563736 complement(4087621..4088415) 1 NC_012207.1 hydrolase 4088415 7563736 JTY_3736 Mycobacterium bovis BCG str. Tokyo 172 hydrolase YP_002646775.1 4087621 R 561275 CDS YP_002646776.1 224992087 7563737 complement(4088422..4088877) 1 NC_012207.1 hypothetical protein 4088877 7563737 JTY_3737 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646776.1 4088422 R 561275 CDS YP_002646777.1 224992088 7563738 complement(4088893..4089054) 1 NC_012207.1 hypothetical protein 4089054 7563738 JTY_3738 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646777.1 4088893 R 561275 CDS YP_002646778.1 224992089 7563739 4089139..4090161 1 NC_012207.1 anion transporter ATPase 4090161 7563739 JTY_3739 Mycobacterium bovis BCG str. Tokyo 172 anion transporter ATPase YP_002646778.1 4089139 D 561275 CDS YP_002646779.1 224992090 7563740 4090158..4091318 1 NC_012207.1 anion transporter ATPase 4091318 7563740 JTY_3740 Mycobacterium bovis BCG str. Tokyo 172 anion transporter ATPase YP_002646779.1 4090158 D 561275 CDS YP_002646780.1 224992091 7563741 complement(4091561..4091917) 1 NC_012207.1 transcriptional regulatory protein whiB-like 4091917 whiB4 7563741 whiB4 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein whiB-like YP_002646780.1 4091561 R 561275 CDS YP_002646781.1 224992092 7561692 4092279..4094711 1 NC_012207.1 bifunctional membrane-associated penicillin-binding protein 1A/1B 4094711 ponA2 7561692 ponA2 Mycobacterium bovis BCG str. Tokyo 172 bifunctional membrane-associated penicillin-binding protein 1A/1B YP_002646781.1 4092279 D 561275 CDS YP_002646782.1 224992093 7562141 4094780..4095739 1 NC_012207.1 hypothetical protein 4095739 7562141 JTY_3743 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646782.1 4094780 D 561275 CDS YP_002646783.1 224992094 7563742 4095802..4096842 1 NC_012207.1 lyase 4096842 7563742 JTY_3744 Mycobacterium bovis BCG str. Tokyo 172 lyase YP_002646783.1 4095802 D 561275 CDS YP_002646784.1 224992095 7560833 complement(4097658..4099088) 1 NC_012207.1 Differs from Rv3685c by 1aa, Q136E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; cytochrome P450 137 4099088 cyp137 7560833 cyp137 Mycobacterium bovis BCG str. Tokyo 172 cytochrome P450 137 YP_002646784.1 4097658 R 561275 CDS YP_002646785.1 224992096 7563163 complement(4099114..4099446) 1 NC_012207.1 hypothetical protein 4099446 7563163 JTY_3746 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646785.1 4099114 R 561275 CDS YP_002646786.1 224992097 7563744 complement(4099686..4099931) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, truncation at the 5' start due to a single base transversion (G-T) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (81 aa versus 122 aa); hypothetical protein 4099931 7563744 JTY_3747 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646786.1 4099686 R 561275 CDS YP_002646787.1 224992098 7563745 complement(4100256..4100720) 1 NC_012207.1 hypothetical protein 4100720 7563745 JTY_3748 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646787.1 4100256 R 561275 CDS YP_002646788.1 224992099 7563746 4100720..4102075 1 NC_012207.1 Differs from Rv3689 by 1aa, L119V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 4102075 7563746 JTY_3749 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646788.1 4100720 D 561275 CDS YP_002646789.1 224992100 7563747 4102102..4102755 1 NC_012207.1 hypothetical protein 4102755 7563747 JTY_3750 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646789.1 4102102 D 561275 CDS YP_002646790.1 224992101 7563748 4102881..4103882 1 NC_012207.1 hypothetical protein 4103882 7563748 JTY_3751 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646790.1 4102881 D 561275 CDS YP_002646791.1 224992102 7563749 4103879..4104955 1 NC_012207.1 methanol dehydrogenase transcriptional regulatory protein 4104955 moxR2 7563749 moxR2 Mycobacterium bovis BCG str. Tokyo 172 methanol dehydrogenase transcriptional regulatory protein YP_002646791.1 4103879 D 561275 CDS YP_002646792.1 224992103 7563548 4105089..4106411 1 NC_012207.1 Differs from Rv3693 by 2aa, V178L, P214A in BCG Tokyo.; hypothetical protein 4106411 7563548 JTY_3753 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646792.1 4105089 D 561275 CDS YP_002646793.1 224992104 7563750 complement(4106485..4107477) 1 NC_012207.1 transmembrane protein 4107477 7563750 JTY_3754 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646793.1 4106485 R 561275 CDS YP_002646794.1 224992105 7563751 4107569..4108501 1 NC_012207.1 hypothetical protein 4108501 7563751 JTY_3755 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646794.1 4107569 D 561275 CDS YP_002646795.1 224992106 7563752 complement(4108565..4110121) 1 NC_012207.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 4110121 glpK 7563752 glpK Mycobacterium bovis BCG str. Tokyo 172 glycerol kinase YP_002646795.1 4108565 R 561275 CDS YP_002646796.1 224992107 7561941 complement(4110171..4110608) 1 NC_012207.1 Differs from Rv3697c by 1aa, R34G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4110608 7561941 JTY_3757 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646796.1 4110171 R 561275 CDS YP_002646797.1 224992108 7563753 complement(4110605..4110829) 1 NC_012207.1 hypothetical protein 4110829 7563753 JTY_3758 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646797.1 4110605 R 561275 CDS YP_002646798.1 224992109 7563754 4110859..4112388 1 NC_012207.1 Differs from Rv3698 by 3aa, I66M, R233P, A288V and from Mb3724 by 1aa, A288V in BCG Pasteur and BCG Tokyo; hypothetical protein 4112388 7563754 JTY_3759 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646798.1 4110859 D 561275 CDS YP_002646799.1 224992110 7563755 4112410..4113111 1 NC_012207.1 hypothetical protein 4113111 7563755 JTY_3760 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646799.1 4112410 D 561275 CDS YP_002646800.1 224992111 7563756 complement(4113114..4114286) 1 NC_012207.1 hypothetical protein 4114286 7563756 JTY_3761 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646800.1 4113114 R 561275 CDS YP_002646801.1 224992112 7563757 complement(4114317..4115282) 1 NC_012207.1 hypothetical protein 4115282 7563757 JTY_3762 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646801.1 4114317 R 561275 CDS YP_002646802.1 224992113 7562610 complement(4115279..4115980) 1 NC_012207.1 hypothetical protein 4115980 7562610 JTY_3763 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646802.1 4115279 R 561275 CDS YP_002646803.1 224992114 7562611 complement(4115980..4117257) 1 NC_012207.1 hypothetical protein 4117257 7562611 JTY_3764 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646803.1 4115980 R 561275 CDS YP_002646804.1 224992115 7562612 complement(4117254..4118552) 1 NC_012207.1 gamma-glutamylcystein synthetase, gamma-ECS, GCS, gamma-glutamyl-L-cysteine synthetase; glutamate--cysteine ligase GshA 4118552 gshA 7562612 gshA Mycobacterium bovis BCG str. Tokyo 172 glutamate--cysteine ligase GshA YP_002646804.1 4117254 R 561275 CDS YP_002646805.1 224992116 7563286 complement(4118684..4119328) 1 NC_012207.1 hypothetical protein 4119328 7563286 JTY_3766 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646805.1 4118684 R 561275 CDS YP_002646806.1 224992117 7562613 complement(4119457..4119846) 1 NC_012207.1 hypothetical protein 4119846 7562613 JTY_3767 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646806.1 4119457 R 561275 CDS YP_002646807.1 224992118 7562614 complement(4119957..4120277) 1 NC_012207.1 hypothetical protein 4120277 7562614 JTY_3768 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646807.1 4119957 R 561275 CDS YP_002646808.1 224992119 7562615 complement(4120396..4121406) 1 NC_012207.1 hypothetical protein 4121406 7562615 JTY_3769 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646808.1 4120396 R 561275 CDS YP_002646809.1 224992120 7562616 complement(4121546..4122583) 1 NC_012207.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 4122583 asd 7562616 asd Mycobacterium bovis BCG str. Tokyo 172 aspartate-semialdehyde dehydrogenase YP_002646809.1 4121546 R 561275 CDS YP_002646810.1 224992121 7562039 complement(4122584..4123849) 1 NC_012207.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 4123849 ask 7562039 ask Mycobacterium bovis BCG str. Tokyo 172 aspartate kinase YP_002646810.1 4122584 R 561275 CDS YP_002646811.1 224992122 7562040 4124106..4126553 1 NC_012207.1 Protein is 190 aa longer than Rv3710, and 57 aalonger than Mb3737 due to differences in copy number of 19codon repeat at 3'-end; 2-isopropylmalate synthase 4126553 leuA 7562040 leuA Mycobacterium bovis BCG str. Tokyo 172 2-isopropylmalate synthase YP_002646811.1 4124106 D 561275 CDS YP_002646812.1 224992123 7562813 complement(4126619..4127608) 1 NC_012207.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 4127608 dnaQ 7562813 dnaQ Mycobacterium bovis BCG str. Tokyo 172 DNA polymerase III subunit epsilon YP_002646812.1 4126619 R 561275 CDS YP_002646813.1 224992124 7561508 4127742..4128983 1 NC_012207.1 Differs from Rv3712 by 2aa, S200G, T351K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; ligase 4128983 7561508 JTY_3774 Mycobacterium bovis BCG str. Tokyo 172 ligase YP_002646813.1 4127742 D 561275 CDS YP_002646814.1 224992125 7562617 4128988..4129683 1 NC_012207.1 cobyric acid synthase 4129683 cobQ2 7562617 cobQ2 Mycobacterium bovis BCG str. Tokyo 172 cobyric acid synthase YP_002646814.1 4128988 D 561275 CDS YP_002646815.1 224992126 7563116 complement(4129692..4130582) 1 NC_012207.1 hypothetical protein 4130582 7563116 JTY_3776 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646815.1 4129692 R 561275 CDS YP_002646816.1 224992127 7562618 complement(4130650..4131261) 1 NC_012207.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 4131261 recR 7562618 recR Mycobacterium bovis BCG str. Tokyo 172 recombination protein RecR YP_002646816.1 4130650 R 561275 CDS YP_002646817.1 224992128 7561562 complement(4131273..4131674) 1 NC_012207.1 hypothetical protein 4131674 7561562 JTY_3778 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646817.1 4131273 R 561275 CDS YP_002646818.1 224992129 7562619 4131809..4132534 1 NC_012207.1 hypothetical protein 4132534 7562619 JTY_3779 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646818.1 4131809 D 561275 CDS YP_002646819.1 224992130 7562620 complement(4132576..4133019) 1 NC_012207.1 hypothetical protein 4133019 7562620 JTY_3780 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646819.1 4132576 R 561275 CDS YP_002646820.1 224992131 7562621 4133067..4134479 1 NC_012207.1 Differs from Rv3719 by 1aa, A12T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4134479 7562621 JTY_3781 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646820.1 4133067 D 561275 CDS YP_002646821.1 224992132 7562622 4134497..4135759 1 NC_012207.1 fatty acid synthase 4135759 7562622 JTY_3782 Mycobacterium bovis BCG str. Tokyo 172 fatty acid synthase YP_002646821.1 4134497 D 561275 CDS YP_002646822.1 224992133 7562623 complement(4135756..4137492) 1 NC_012207.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 4137492 dnaZX 7562623 dnaZX Mycobacterium bovis BCG str. Tokyo 172 DNA polymerase III subunits gamma and tau YP_002646822.1 4135756 R 561275 CDS YP_002646823.1 224992134 7561509 complement(4137582..4138889) 1 NC_012207.1 Differs from Rv3722c and Mb3749c by 1aa, Y314H in BCG Pasteur and BCG Tokyo; hypothetical protein 4138889 7561509 JTY_3784 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646823.1 4137582 R 561275 CDS YP_002646824.1 224992135 7560787 4139297..4140061 1 NC_012207.1 transmembrane protein 4140061 7560787 JTY_3785 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646824.1 4139297 D 561275 CDS YP_002646825.1 224992136 7562625 4140228..4140929 1 NC_012207.1 In Mycobacterium tuberculosis, Rv3724A and Rv3724B exist as 2 genes with an overlap region between them. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a single base deletion (T-*) leads to a single product; cutinase precursor 4140929 cut5 7562625 cut5 Mycobacterium bovis BCG str. Tokyo 172 cutinase precursor YP_002646825.1 4140228 D 561275 CDS YP_002646826.1 224992137 7563146 4140974..4141975 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base insertion (*-A) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (333 aa versus 309 aa); oxidoreductase 4141975 7563146 JTY_3787 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646826.1 4140974 D 561275 CDS YP_002646827.1 224992138 7562626 4142182..4143375 1 NC_012207.1 Differs from Rv3726 by 1aa, S251R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; dehydrogenase 4143375 7562626 JTY_3788 Mycobacterium bovis BCG str. Tokyo 172 dehydrogenase YP_002646827.1 4142182 D 561275 CDS YP_002646828.1 224992139 7562627 4143716..4145524 1 NC_012207.1 Differs from Rv3727 by 1aa, M86V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 4145524 7562627 JTY_3789 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646828.1 4143716 D 561275 CDS YP_002646829.1 224992140 7562628 4145634..4148831 1 NC_012207.1 Differs from Rv3728 by 1aa, R464G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; two-domain membrane protein 4148831 7562628 JTY_3790 Mycobacterium bovis BCG str. Tokyo 172 two-domain membrane protein YP_002646829.1 4145634 D 561275 CDS YP_002646830.1 224992141 7562629 4149046..4151376 1 NC_012207.1 Differs from Rv3729 by 2aa, I170V, S269P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transferase 4151376 7562629 JTY_3791 Mycobacterium bovis BCG str. Tokyo 172 transferase YP_002646830.1 4149046 D 561275 CDS YP_002646831.1 224992142 7562630 complement(4151441..4152481) 1 NC_012207.1 hypothetical protein 4152481 7562630 JTY_3792 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646831.1 4151441 R 561275 CDS YP_002646832.1 224992143 7562631 4152519..4153595 1 NC_012207.1 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth; ATP-dependent DNA ligase 4153595 ligC 7562631 ligC Mycobacterium bovis BCG str. Tokyo 172 ATP-dependent DNA ligase YP_002646832.1 4152519 D 561275 CDS YP_002646833.1 224992144 7562828 4153695..4154753 1 NC_012207.1 hypothetical protein 4154753 7562828 JTY_3794 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646833.1 4153695 D 561275 CDS YP_002646834.1 224992145 7562632 complement(4154773..4155273) 1 NC_012207.1 hypothetical protein 4155273 7562632 JTY_3795 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646834.1 4154773 R 561275 CDS YP_002646835.1 224992146 7562633 complement(4155287..4156651) 1 NC_012207.1 hypothetical protein 4156651 7562633 JTY_3796 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646835.1 4155287 R 561275 CDS YP_002646836.1 224992147 7562634 4156850..4157338 1 NC_012207.1 hypothetical protein 4157338 7562634 JTY_3797 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646836.1 4156850 D 561275 CDS YP_002646837.1 224992148 7562635 4157395..4158456 1 NC_012207.1 Differs from Rv3736 and Mb3763 by 1aa, K76E in BCG Pasteur and BCG Tokyo.; probably AraC/XylS-family; transcriptional regulatory protein 4158456 7562635 JTY_3798 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646837.1 4157395 D 561275 CDS YP_002646838.1 224992149 7562636 4158460..4160049 1 NC_012207.1 Differs from Rv3737 by 1aa, G40D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; transmembrane protein 4160049 7562636 JTY_3799 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646838.1 4158460 D 561275 CDS YP_002646839.1 224992150 7560799 complement(4160428..4161774) 1 NC_012207.1 Differs from Rv3740c by 1aa, C422R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; hypothetical protein 4161774 7560799 JTY_3801 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646839.1 4160428 R 561275 CDS YP_002646840.1 224992151 7562638 complement(4161774..4162448) 1 NC_012207.1 oxidoreductase 4162448 7562638 JTY_3802 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646840.1 4161774 R 561275 CDS YP_002646841.1 224992152 7562639 complement(4162445..4162840) 1 NC_012207.1 oxidoreductase 4162840 7562639 JTY_3803 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646841.1 4162445 R 561275 CDS YP_002646842.1 224992153 7562640 complement(4162986..4164968) 1 NC_012207.1 cation transporter P-type ATPase 4164968 ctpJ 7562640 ctpJ Mycobacterium bovis BCG str. Tokyo 172 cation transporter P-type ATPase YP_002646842.1 4162986 R 561275 CDS YP_002646843.1 224992154 7563140 4165035..4165397 1 NC_012207.1 probably ArsR-family; transcriptional regulatory protein 4165397 7563140 JTY_3805 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646843.1 4165035 D 561275 CDS YP_002646844.1 224992155 7562641 complement(4165481..4165693) 1 NC_012207.1 hypothetical protein 4165693 7562641 JTY_3806 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646844.1 4165481 R 561275 CDS YP_002646845.1 224992156 7562642 complement(4165766..4166101) 1 NC_012207.1 PE family protein 4166101 PE34 7562642 PE34 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002646845.1 4165766 R 561275 CDS YP_002646846.1 224992157 7561733 4166319..4166702 1 NC_012207.1 hypothetical protein 4166702 7561733 JTY_3808 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646846.1 4166319 D 561275 CDS YP_002646847.1 224992158 7562643 4166832..4167191 1 NC_012207.1 Differs from Rv3748 by 1aa, D107G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; hypothetical protein 4167191 7562643 JTY_3809 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646847.1 4166832 D 561275 CDS YP_002646848.1 224992159 7562644 complement(4167224..4167733) 1 NC_012207.1 hypothetical protein 4167733 7562644 JTY_3810 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646848.1 4167224 R 561275 CDS YP_002646849.1 224992160 7562645 complement(4167801..4168193) 1 NC_012207.1 excisionase 4168193 7562645 JTY_3811 Mycobacterium bovis BCG str. Tokyo 172 excisionase YP_002646849.1 4167801 R 561275 CDS YP_002646850.1 224992161 7562646 4168469..4168684 1 NC_012207.1 integrase 4168684 7562646 JTY_3812 Mycobacterium bovis BCG str. Tokyo 172 integrase YP_002646850.1 4168469 D 561275 CDS YP_002646851.1 224992162 7560788 complement(4168842..4169300) 1 NC_012207.1 cytidine/deoxycytidylate deaminase 4169300 7560788 JTY_3813 Mycobacterium bovis BCG str. Tokyo 172 cytidine/deoxycytidylate deaminase YP_002646851.1 4168842 R 561275 CDS YP_002646852.1 224992163 7562648 complement(4169316..4169837) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (t-c) leads to a longer product with a different 5' start compared to its homolog in Mycobacterium tuberculosis strain H37Rv(173 aa versus 166 aa); hypothetical protein 4169837 7562648 JTY_3814 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646852.1 4169316 R 561275 CDS YP_002646853.1 224992164 7562649 4170016..4170921 1 NC_012207.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 4170921 tyrA 7562649 tyrA Mycobacterium bovis BCG str. Tokyo 172 prephenate dehydrogenase YP_002646853.1 4170016 D 561275 CDS YP_002646854.1 224992165 7561646 complement(4170884..4171483) 1 NC_012207.1 hypothetical protein 4171483 7561646 JTY_3816 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646854.1 4170884 R 561275 CDS YP_002646855.1 224992166 7562650 complement(4171489..4172208) 1 NC_012207.1 osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter 4172208 proZ 7562650 proZ Mycobacterium bovis BCG str. Tokyo 172 osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter YP_002646855.1 4171489 R 561275 CDS YP_002646856.1 224992167 7560834 complement(4172205..4172894) 1 NC_012207.1 osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter 4172894 proW 7560834 proW Mycobacterium bovis BCG str. Tokyo 172 osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter YP_002646856.1 4172205 R 561275 CDS YP_002646857.1 224992168 7560831 complement(4172882..4174012) 1 NC_012207.1 osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter 4174012 proV 7560831 proV Mycobacterium bovis BCG str. Tokyo 172 osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter YP_002646857.1 4172882 R 561275 CDS YP_002646858.1 224992169 7560830 complement(4174021..4174968) 1 NC_012207.1 Differs from Rv3759c by 2aa, P85L, V176A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein 4174968 proX 7560830 proX Mycobacterium bovis BCG str. Tokyo 172 osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein YP_002646858.1 4174021 R 561275 CDS YP_002646859.1 224992170 7560832 4175133..4175435 1 NC_012207.1 hypothetical protein 4175435 7560832 JTY_3821 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646859.1 4175133 D 561275 CDS YP_002646860.1 224992171 7562651 complement(4175457..4176512) 1 NC_012207.1 acyl-CoA dehydrogenase 4176512 fadE36 7562651 fadE36 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002646860.1 4175457 R 561275 CDS YP_002646861.1 224992172 7563386 complement(4176591..4178471) 1 NC_012207.1 Differs from Rv3762c by 1aa, H345Y and from Mb3788c by 1aa, V161G in BCG Pasteur and BCG Tokyo; hydrolase 4178471 7563386 JTY_3823 Mycobacterium bovis BCG str. Tokyo 172 hydrolase YP_002646861.1 4176591 R 561275 CDS YP_002646862.1 224992173 7562652 4178642..4179121 1 NC_012207.1 19 kDa lipoprotein antigen precursor 4179121 lpqH 7562652 lpqH Mycobacterium bovis BCG str. Tokyo 172 19 kDa lipoprotein antigen precursor YP_002646862.1 4178642 D 561275 CDS YP_002646863.1 224992174 7560500 complement(4179177..4180604) 1 NC_012207.1 Differs from Rv3764c by 2aa, R45H, R246C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; two component sensor kinase 4180604 7560500 JTY_3825 Mycobacterium bovis BCG str. Tokyo 172 two component sensor kinase YP_002646863.1 4179177 R 561275 CDS YP_002646864.1 224992175 7562653 complement(4180675..4181379) 1 NC_012207.1 two component transcriptional regulatory protein 4181379 7562653 JTY_3826 Mycobacterium bovis BCG str. Tokyo 172 two component transcriptional regulatory protein YP_002646864.1 4180675 R 561275 CDS YP_002646865.1 224992176 7562654 4181888..4182577 1 NC_012207.1 hypothetical protein 4182577 7562654 JTY_3827 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646865.1 4181888 D 561275 CDS YP_002646866.1 224992177 7562655 complement(4182591..4183535) 1 NC_012207.1 hypothetical protein 4183535 7562655 JTY_3828 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646866.1 4182591 R 561275 CDS YP_002646867.1 224992178 7562656 4183665..4184024 1 NC_012207.1 hypothetical protein 4184024 7562656 JTY_3829 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646867.1 4183665 D 561275 CDS YP_002646868.1 224992179 7562657 4184210..4184482 1 NC_012207.1 hypothetical protein 4184482 7562657 JTY_3830 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646868.1 4184210 D 561275 CDS YP_002646869.1 224992180 7562658 complement(4184795..4185370) 1 NC_012207.1 Differs from Rv3770c by 1aa, A98P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; hypothetical leucine rich protein 4185370 7562658 JTY_3831 Mycobacterium bovis BCG str. Tokyo 172 hypothetical leucine rich protein YP_002646869.1 4184795 R 561275 CDS YP_002646870.1 224992181 7562659 complement(4185476..4185658) 1 NC_012207.1 remnant of a transposase 4185658 7562659 JTY_3832 Mycobacterium bovis BCG str. Tokyo 172 remnant of a transposase YP_002646870.1 4185476 R 561275 CDS YP_002646871.1 224992182 7562660 complement(4185673..4185864) 1 NC_012207.1 remnant of a transposase 4185864 7562660 JTY_3833 Mycobacterium bovis BCG str. Tokyo 172 remnant of a transposase YP_002646871.1 4185673 R 561275 CDS YP_002646872.1 224992183 7562661 complement(4185999..4186325) 1 NC_012207.1 hypothetical protein 4186325 7562661 JTY_3834 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646872.1 4185999 R 561275 CDS YP_002646873.1 224992184 7560785 4186729..4187790 1 NC_012207.1 Differs from Rv3772 by 1aa, A142T in Mycobacterium bovis, BCG Pasteur and BCG Tokyo.; aminotransferase 4187790 hisC2 7560785 hisC2 Mycobacterium bovis BCG str. Tokyo 172 aminotransferase YP_002646873.1 4186729 D 561275 CDS YP_002646874.1 224992185 7563311 complement(4187836..4188180) 1 NC_012207.1 In Mycobacterium tuberculosis Rv3773c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo, a frameshift due to a single base insertion (*-A) splits Rv3773c in two parts; hypothetical protein 4188180 7563311 JTY_3836 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646874.1 4187836 R 561275 CDS YP_002646875.1 224992186 7562663 complement(4188185..4188421) 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv, Rv3773c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-A) splits Rv3773c into 2 parts; hypothetical protein 4188421 7562663 JTY_3837 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646875.1 4188185 R 561275 CDS YP_002646876.1 224992187 7562664 4188445..4189269 1 NC_012207.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 4189269 echA21 7562664 echA21 Mycobacterium bovis BCG str. Tokyo 172 enoyl-CoA hydratase YP_002646876.1 4188445 D 561275 CDS YP_002646877.1 224992188 7561533 4189281..4190528 1 NC_012207.1 lipase 4190528 lipE 7561533 lipE Mycobacterium bovis BCG str. Tokyo 172 lipase YP_002646877.1 4189281 D 561275 CDS YP_002646879.1 224992189 7560786 4192290..4193276 1 NC_012207.1 Differs from Rv3777 by 1aa, A160V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 4193276 7560786 JTY_3841 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646879.1 4192290 D 561275 CDS YP_002646880.1 224992190 7562665 complement(4193295..4194491) 1 NC_012207.1 aminotransferase 4194491 7562665 JTY_3842 Mycobacterium bovis BCG str. Tokyo 172 aminotransferase YP_002646880.1 4193295 R 561275 CDS YP_002646881.1 224992191 7562666 4194581..4196581 1 NC_012207.1 transmembrane protein alanine and leucine rich 4196581 7562666 JTY_3843 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein alanine and leucine rich YP_002646881.1 4194581 D 561275 CDS YP_002646882.1 224992192 7562667 4196585..4197121 1 NC_012207.1 hypothetical protein 4197121 7562667 JTY_3844 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646882.1 4196585 D 561275 CDS YP_002646883.1 224992193 7562668 4197125..4197946 1 NC_012207.1 O-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter 4197946 rbfE 7562668 rbfE Mycobacterium bovis BCG str. Tokyo 172 O-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter YP_002646883.1 4197125 D 561275 CDS YP_002646884.1 224992194 7561551 4197943..4198857 1 NC_012207.1 L-rhamnosyltransferase 4198857 7561551 JTY_3846 Mycobacterium bovis BCG str. Tokyo 172 L-rhamnosyltransferase YP_002646884.1 4197943 D 561275 CDS YP_002646885.1 224992195 7562669 4198854..4199696 1 NC_012207.1 O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter 4199696 rfbD 7562669 rfbD Mycobacterium bovis BCG str. Tokyo 172 O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter YP_002646885.1 4198854 D 561275 CDS YP_002646886.1 224992196 7561567 4199852..4200832 1 NC_012207.1 dTDP-glucose 4,6-dehydratase 4200832 rfbB 7561567 rfbB Mycobacterium bovis BCG str. Tokyo 172 dTDP-glucose 4,6-dehydratase YP_002646886.1 4199852 D 561275 CDS YP_002646887.1 224992197 7561566 4200916..4201989 1 NC_012207.1 hypothetical protein 4201989 7561566 JTY_3849 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646887.1 4200916 D 561275 CDS YP_002646888.1 224992198 7562670 complement(4201970..4203193) 1 NC_012207.1 hypothetical protein 4203193 7562670 JTY_3850 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646888.1 4201970 R 561275 CDS YP_002646889.1 224992199 7562671 complement(4203206..4204132) 1 NC_012207.1 hypothetical protein 4204132 7562671 JTY_3851 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646889.1 4203206 R 561275 CDS YP_002646890.1 224992200 7562672 4204376..4204861 1 NC_012207.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 4204861 7562672 JTY_3852 Mycobacterium bovis BCG str. Tokyo 172 nucleoside diphosphate kinase regulator YP_002646890.1 4204376 D 561275 CDS YP_002646891.1 224992201 7562673 4204970..4205335 1 NC_012207.1 hypothetical protein 4205335 7562673 JTY_3853 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646891.1 4204970 D 561275 CDS YP_002646892.1 224992202 7562674 4205375..4206760 1 NC_012207.1 oxidoreductase 4206760 7562674 JTY_3854 Mycobacterium bovis BCG str. Tokyo 172 oxidoreductase YP_002646892.1 4205375 D 561275 CDS YP_002646893.1 224992203 7562675 4206761..4207525 1 NC_012207.1 short chain dehydrogenase 4207525 7562675 JTY_3855 Mycobacterium bovis BCG str. Tokyo 172 short chain dehydrogenase YP_002646893.1 4206761 D 561275 CDS YP_002646894.1 224992204 7562676 4207528..4209459 1 NC_012207.1 transmembrane protein 4209459 7562676 JTY_3856 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646894.1 4207528 D 561275 CDS YP_002646895.1 224992205 7562677 4209459..4212743 1 NC_012207.1 Differs from Rv3793 by 1aa, I270T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; indolylacetylinositol arabinosyltransferase 4212743 embC 7562677 embC Mycobacterium bovis BCG str. Tokyo 172 indolylacetylinositol arabinosyltransferase YP_002646895.1 4209459 D 561275 CDS YP_002646896.1 224992206 7562859 4212829..4216113 1 NC_012207.1 indolylacetylinositol arabinosyltransferase 4216113 embA 7562859 embA Mycobacterium bovis BCG str. Tokyo 172 indolylacetylinositol arabinosyltransferase YP_002646896.1 4212829 D 561275 CDS YP_002646897.1 224992207 7562857 4216110..4219406 1 NC_012207.1 Differs from Rv3795 by 2aa, S13N, A378E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; indolylacetylinositol arabinosyltransferase 4219406 embB 7562857 embB Mycobacterium bovis BCG str. Tokyo 172 indolylacetylinositol arabinosyltransferase YP_002646897.1 4216110 D 561275 CDS YP_002646898.1 224992208 7562858 4219474..4220601 1 NC_012207.1 Differs from Rv3796 by 1aa, I320T in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 4220601 7562858 JTY_3860 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646898.1 4219474 D 561275 CDS YP_002646899.1 224992209 7562678 4220681..4222462 1 NC_012207.1 acyl-CoA dehydrogenase 4222462 fadE35 7562678 fadE35 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA dehydrogenase YP_002646899.1 4220681 D 561275 CDS YP_002646900.1 224992210 7563385 4222589..4223923 1 NC_012207.1 In Mycobacterium tuberculosis strain H37Rv (Rv3798), Mycobacterium bovis BCG Pasteur (BCG_3860), and BCG Tokyo, exist as a single gene. In Mycobacterium bovis, a frameshift due to a 11 bp deletion splits Rv3798 into 2 parts, Mb3827 and Mb3828. In Mycobacterium bovis, a frameshift due to a 11 bp deletion splits Rv3798 into 2 parts, Mb3827 and Mb3828; transposase 4223923 7563385 JTY_3862 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646900.1 4222589 D 561275 CDS YP_002646901.1 224992211 7562679 complement(4223976..4225544) 1 NC_012207.1 propionyl-CoA carboxylase beta chain 4 4225544 accD4 7562679 accD4 Mycobacterium bovis BCG str. Tokyo 172 propionyl-CoA carboxylase beta chain 4 YP_002646901.1 4223976 R 561275 CDS YP_002646902.1 224992212 7563924 complement(4225541..4230742) 1 NC_012207.1 Differs from Rv3800c by 2aa, G523A, N650S and from Mb3829c by 1aa, N650S in BCG Pasteur and BCG Tokyo; polyketide synthase 4230742 pks13 7563924 pks13 Mycobacterium bovis BCG str. Tokyo 172 polyketide synthase YP_002646902.1 4225541 R 561275 CDS YP_002646903.1 224992213 7562444 complement(4230749..4232662) 1 NC_012207.1 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 4232662 fadD32 7562444 fadD32 Mycobacterium bovis BCG str. Tokyo 172 long-chain-fatty-acid--CoA ligase YP_002646903.1 4230749 R 561275 CDS YP_002646904.1 224992214 7563348 complement(4232951..4233961) 1 NC_012207.1 hypothetical protein 4233961 7563348 JTY_3866 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646904.1 4232951 R 561275 CDS YP_002646905.1 224992215 7562680 complement(4234159..4235058) 1 NC_012207.1 MPT51/MPB51 antigen protein 4235058 fbpD 7562680 fbpD Mycobacterium bovis BCG str. Tokyo 172 MPT51/MPB51 antigen protein YP_002646905.1 4234159 R 561275 CDS YP_002646906.1 224992216 7563403 complement(4235238..4236254) 1 NC_012207.1 antigen 85-A 4236254 fbpA 7563403 fbpA Mycobacterium bovis BCG str. Tokyo 172 antigen 85-A YP_002646906.1 4235238 R 561275 CDS YP_002646907.1 224992217 7563400 complement(4236549..4238432) 1 NC_012207.1 Differs from Rv3805c by 1aa, V327I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 4238432 7563400 JTY_3869 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646907.1 4236549 R 561275 CDS YP_002646908.1 224992218 7562681 complement(4238521..4239429) 1 NC_012207.1 catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate; phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase 4239429 7562681 JTY_3870 Mycobacterium bovis BCG str. Tokyo 172 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase YP_002646908.1 4238521 R 561275 CDS YP_002646909.1 224992219 7562682 complement(4239436..4239933) 1 NC_012207.1 transmembrane protein 4239933 7562682 JTY_3871 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646909.1 4239436 R 561275 CDS YP_002646910.1 224992220 7562683 complement(4239962..4241875) 1 NC_012207.1 galactofuranosyl transferase 4241875 7562683 JTY_3872 Mycobacterium bovis BCG str. Tokyo 172 galactofuranosyl transferase YP_002646910.1 4239962 R 561275 CDS YP_002646911.1 224992221 7562684 complement(4241872..4243071) 1 NC_012207.1 UDP-galactopyranose mutase 4243071 glf 7562684 glf Mycobacterium bovis BCG str. Tokyo 172 UDP-galactopyranose mutase YP_002646911.1 4241872 R 561275 CDS YP_002646912.1 224992222 7561919 4243335..4244189 1 NC_012207.1 exported repetitive protein precursor 4244189 pirG 7561919 pirG Mycobacterium bovis BCG str. Tokyo 172 exported repetitive protein precursor YP_002646912.1 4243335 D 561275 CDS YP_002646913.1 224992223 7562425 4244394..4246013 1 NC_012207.1 hypothetical protein 4246013 7562425 JTY_3875 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646913.1 4244394 D 561275 CDS YP_002646914.1 224992224 7562685 4246167..4247681 1 NC_012207.1 PE-PGRS family protein 4247681 PE_PGRS62 7562685 PE_PGRS62 Mycobacterium bovis BCG str. Tokyo 172 PE-PGRS family protein YP_002646914.1 4246167 D 561275 CDS YP_002646915.1 224992225 7562388 complement(4247990..4248811) 1 NC_012207.1 Differs from Rv3813c by 1aa, T83M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4248811 7562388 JTY_3877 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646915.1 4247990 R 561275 CDS YP_002646916.1 224992226 7562686 complement(4248826..4249608) 1 NC_012207.1 3-bp:GGC deletion in BCG Tokyo after (188-190):GGC of Rv3814c; acyltransferase 4249608 7562686 JTY_3878 Mycobacterium bovis BCG str. Tokyo 172 acyltransferase YP_002646916.1 4248826 R 561275 CDS YP_002646917.1 224992227 7562687 complement(4249626..4250381) 1 NC_012207.1 acyltransferase 4250381 7562687 JTY_3879 Mycobacterium bovis BCG str. Tokyo 172 acyltransferase YP_002646917.1 4249626 R 561275 CDS YP_002646918.1 224992228 7562688 complement(4250385..4251164) 1 NC_012207.1 acyltransferase 4251164 7562688 JTY_3880 Mycobacterium bovis BCG str. Tokyo 172 acyltransferase YP_002646918.1 4250385 R 561275 CDS YP_002646919.1 224992229 7562689 4251240..4251995 1 NC_012207.1 phosphotransferase 4251995 7562689 JTY_3881 Mycobacterium bovis BCG str. Tokyo 172 phosphotransferase YP_002646919.1 4251240 D 561275 CDS YP_002646920.1 224992230 7562690 4252042..4253592 1 NC_012207.1 hypothetical protein 4253592 7562690 JTY_3882 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646920.1 4252042 D 561275 CDS YP_002646921.1 224992231 7562691 4253589..4253924 1 NC_012207.1 hypothetical protein 4253924 7562691 JTY_3883 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646921.1 4253589 D 561275 CDS YP_002646922.1 224992232 7564251 complement(4254012..4255418) 1 NC_012207.1 Differs from Rv3820c by 1aa, I463T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; polyketide synthase associated protein 4255418 papA2 7564251 papA2 Mycobacterium bovis BCG str. Tokyo 172 polyketide synthase associated protein YP_002646922.1 4254012 R 561275 CDS YP_002646923.1 224992233 7562512 4255566..4256279 1 NC_012207.1 Differs from Rv3821 by 2aa, N106D, T120A; integral membrane protein 4256279 7562512 JTY_3885 Mycobacterium bovis BCG str. Tokyo 172 integral membrane protein YP_002646923.1 4255566 D 561275 CDS YP_002646924.1 224992234 7564252 4256314..4256682 1 NC_012207.1 Corresponds to Rv3822/Mb3852 but is missing 1bp after codon 122. Differs from Rv3822 by 2aa, Y55C, T103N, in first part (and by 1aa, V92A, in the second part); hypothetical protein 4256682 7564252 JTY_3886 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646924.1 4256314 D 561275 CDS YP_002646925.1 224992235 7564253 4256679..4257527 1 NC_012207.1 Corresponds to 3'-part of Rv3822/Mb3852 due to missing bp after codon 122. Differs from Rv3822 by 1aa, V92A (and by 2aa, Y55C, T105N, in first part); hypothetical protein 4257527 7564253 JTY_3887 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646925.1 4256679 D 561275 CDS YP_002646926.1 224992236 7564254 complement(4257852..4261121) 1 NC_012207.1 Differs from Rv3823c by 2aa, R235G, A526V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane transport protein 4261121 mmpL8 7564254 mmpL8 Mycobacterium bovis BCG str. Tokyo 172 integral membrane transport protein YP_002646926.1 4257852 R 561275 CDS YP_002646927.1 224992237 7564493 complement(4261231..4262766) 1 NC_012207.1 polyketide synthase associated protein 4262766 papA1 7564493 papA1 Mycobacterium bovis BCG str. Tokyo 172 polyketide synthase associated protein YP_002646927.1 4261231 R 561275 CDS YP_002646928.1 224992238 7562511 complement(4262817..4269197) 1 NC_012207.1 Differs from Rv3825c and Mb3855c by 1aa, G829V in BCG Pasteur and BCG Tokyo; polyketide synthase 4269197 pks2 7562511 pks2 Mycobacterium bovis BCG str. Tokyo 172 polyketide synthase YP_002646928.1 4262817 R 561275 CDS YP_002646929.1 224992239 7562119 4269404..4271158 1 NC_012207.1 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 4271158 fadD23 7562119 fadD23 Mycobacterium bovis BCG str. Tokyo 172 acyl-CoA synthetase YP_002646929.1 4269404 D 561275 CDS YP_002646930.1 224992240 7562929 complement(4271155..4272381) 1 NC_012207.1 Differs from Rv3827c by 1aa, A251T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transposase 4272381 7562929 JTY_3892 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646930.1 4271155 R 561275 CDS YP_002646931.1 224992241 7564255 complement(4272378..4272989) 1 NC_012207.1 resolvase 4272989 7564255 JTY_3893 Mycobacterium bovis BCG str. Tokyo 172 resolvase YP_002646931.1 4272378 R 561275 CDS YP_002646932.1 224992242 7564256 complement(4272990..4274600) 1 NC_012207.1 Differs from Rv3829c by 1aa, D55E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; dehydrogenase 4274600 7564256 JTY_3894 Mycobacterium bovis BCG str. Tokyo 172 dehydrogenase YP_002646932.1 4272990 R 561275 CDS YP_002646933.1 224992243 7564257 complement(4274648..4275277) 1 NC_012207.1 probably TetR-family; transcriptional regulatory protein 4275277 7564257 JTY_3895 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646933.1 4274648 R 561275 CDS YP_002646934.1 224992244 7564258 4275349..4275831 1 NC_012207.1 hypothetical protein 4275831 7564258 JTY_3896 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646934.1 4275349 D 561275 CDS YP_002646935.1 224992245 7564259 complement(4275828..4276403) 1 NC_012207.1 hypothetical protein 4276403 7564259 JTY_3897 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646935.1 4275828 R 561275 CDS YP_002646936.1 224992246 7564260 4276459..4277250 1 NC_012207.1 Differs from Rv3833 by 1aa, I105V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably AraC-family; transcriptional regulatory protein 4277250 7564260 JTY_3898 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646936.1 4276459 D 561275 CDS YP_002646937.1 224992247 7564261 complement(4277247..4278506) 1 NC_012207.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 4278506 serS 7564261 serS Mycobacterium bovis BCG str. Tokyo 172 seryl-tRNA synthetase YP_002646937.1 4277247 R 561275 CDS YP_002646938.1 224992248 7560784 4278639..4279988 1 NC_012207.1 Differs from Rv3835 and Mb3865 by 1 aa, Y79N in BCG Pasteur and BCG Tokyo, and frameshift due to extra C in C-string that changes C-terminus in BCG Pasteur.; hypothetical protein 4279988 7560784 JTY_3900 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646938.1 4278639 D 561275 CDS YP_002646939.1 224992249 7564262 4279993..4280343 1 NC_012207.1 In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base insertion (*-G) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (116 aa versus 137 aa); hypothetical protein 4280343 7564262 JTY_3901 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646939.1 4279993 D 561275 CDS YP_002646940.1 224992250 7564263 complement(4280602..4281300) 1 NC_012207.1 phosphoglycerate mutase 4281300 7564263 JTY_3902 Mycobacterium bovis BCG str. Tokyo 172 phosphoglycerate mutase YP_002646940.1 4280602 R 561275 CDS YP_002646941.1 224992251 7564264 complement(4281297..4282262) 1 NC_012207.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 4282262 pheA 7564264 pheA Mycobacterium bovis BCG str. Tokyo 172 prephenate dehydratase YP_002646941.1 4281297 R 561275 CDS YP_002646942.1 224992252 7562404 4282358..4283134 1 NC_012207.1 Differs from Rv3839 by 1aa, S122P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4283134 7562404 JTY_3904 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646942.1 4282358 D 561275 CDS YP_002646943.1 224992253 7564265 4283160..4283573 1 NC_012207.1 transcriptional regulatory protein 4283573 7564265 JTY_3905 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein YP_002646943.1 4283160 D 561275 CDS YP_002646944.1 224992254 7564266 4283771..4284316 1 NC_012207.1 bacterioferritin 4284316 bfrB 7564266 bfrB Mycobacterium bovis BCG str. Tokyo 172 bacterioferritin YP_002646944.1 4283771 D 561275 CDS YP_002646945.1 224992255 7562064 complement(4284331..4285155) 1 NC_012207.1 glycerophosphoryl diester phosphodiesterase 4285155 glpQ1 7562064 glpQ1 Mycobacterium bovis BCG str. Tokyo 172 glycerophosphoryl diester phosphodiesterase YP_002646945.1 4284331 R 561275 CDS YP_002646946.1 224992256 7561942 complement(4285161..4286189) 1 NC_012207.1 Differs from Rv3843c by 2aa, R11G, H92R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 4286189 7561942 JTY_3908 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646946.1 4285161 R 561275 CDS YP_002646947.1 224992257 7564267 4288367..4288858 1 NC_012207.1 transposase 4288858 7564267 JTY_3909 Mycobacterium bovis BCG str. Tokyo 172 transposase YP_002646947.1 4288367 D 561275 CDS YP_002646948.1 224992258 7564268 4288873..4289232 1 NC_012207.1 hypothetical protein 4289232 7564268 JTY_3910 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646948.1 4288873 D 561275 CDS YP_002646949.1 224992259 7564269 4290296..4290919 1 NC_012207.1 Differs from Rv3846 by 1aa, T205I; Fe-superoxide dismutase 4290919 sodA 7564269 sodA Mycobacterium bovis BCG str. Tokyo 172 Fe-superoxide dismutase YP_002646949.1 4290296 D 561275 CDS YP_002646950.1 224992260 7561802 4291130..4291663 1 NC_012207.1 hypothetical protein 4291663 7561802 JTY_3912 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646950.1 4291130 D 561275 CDS YP_002646951.1 224992261 7564270 4291918..4292826 1 NC_012207.1 Differs from Rv3848 by 1aa, I194V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 4292826 7564270 JTY_3913 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646951.1 4291918 D 561275 CDS YP_002646952.1 224992262 7564271 4293091..4293489 1 NC_012207.1 hypothetical protein 4293489 7564271 JTY_3914 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646952.1 4293091 D 561275 CDS YP_002646953.1 224992263 7564272 4293607..4294263 1 NC_012207.1 hypothetical protein 4294263 7564272 JTY_3915 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646953.1 4293607 D 561275 CDS YP_002646954.1 224992264 7564273 4294275..4294559 1 NC_012207.1 hypothetical protein 4294559 7564273 JTY_3916 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646954.1 4294275 D 561275 CDS YP_002646955.1 224992265 7564274 4294666..4295070 1 NC_012207.1 histone-like protein 4295070 hns 7564274 hns Mycobacterium bovis BCG str. Tokyo 172 histone-like protein YP_002646955.1 4294666 D 561275 CDS YP_002646956.1 224992266 7563321 4295087..4295560 1 NC_012207.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 4295560 menG 7563321 menG Mycobacterium bovis BCG str. Tokyo 172 ribonuclease activity regulator protein RraA YP_002646956.1 4295087 D 561275 CDS YP_002646957.1 224992267 7564454 complement(4295596..4297065) 1 NC_012207.1 monooxygenase 4297065 ethA 7564454 ethA Mycobacterium bovis BCG str. Tokyo 172 monooxygenase YP_002646957.1 4295596 R 561275 CDS YP_002646958.1 224992268 7562892 4297141..4297791 1 NC_012207.1 TetR-family; transcriptional regulatory repressor protein 4297791 ethR 7562892 ethR Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory repressor protein YP_002646958.1 4297141 D 561275 CDS YP_002646959.1 224992269 7562893 complement(4297993..4299000) 1 NC_012207.1 hypothetical protein 4299000 7562893 JTY_3921 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646959.1 4297993 R 561275 CDS YP_002646960.1 224992270 7564275 complement(4299009..4299206) 1 NC_012207.1 hypothetical protein 4299206 7564275 JTY_3922 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646960.1 4299009 R 561275 CDS YP_002646961.1 224992271 7564276 complement(4299631..4301097) 1 NC_012207.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 4301097 gltD 7564276 gltD Mycobacterium bovis BCG str. Tokyo 172 glutamate synthase subunit beta YP_002646961.1 4299631 R 561275 CDS YP_002646962.1 224992272 7561948 complement(4301090..4305673) 1 NC_012207.1 Differs from Rv3859c by 1aa, E553Q in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; ferredoxin-dependent glutamate synthase [NADPH] large subunit 4305673 gltB 7561948 gltB Mycobacterium bovis BCG str. Tokyo 172 ferredoxin-dependent glutamate synthase [NADPH] large subunit YP_002646962.1 4301090 R 561275 CDS YP_002646963.1 224992273 7561947 4306369..4307430 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base deletion leads to a shorter product compared to its homologs in Mycobacterium tuberculosis and Mycobacterium bovis; hypothetical protein 4307430 7561947 JTY_3925 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646963.1 4306369 D 561275 CDS YP_002646964.1 224992274 7564277 4307537..4307863 1 NC_012207.1 hypothetical protein 4307863 7564277 JTY_3926 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646964.1 4307537 D 561275 CDS YP_002646965.1 224992275 7564278 complement(4307762..4308112) 1 NC_012207.1 transcriptional regulatory protein WhiB-like 4308112 whiB6 7564278 whiB6 Mycobacterium bovis BCG str. Tokyo 172 transcriptional regulatory protein WhiB-like YP_002646965.1 4307762 R 561275 CDS YP_002646966.1 224992276 7561694 4308439..4309617 1 NC_012207.1 hypothetical alanine rich protein 4309617 7561694 JTY_3928 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine rich protein YP_002646966.1 4308439 D 561275 CDS YP_002646967.1 224992277 7564279 4309860..4311116 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and in Mycobacterium bovis, two in-frame insertion of 36 and 12bp, leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (418 aa versus 402 aa); hypothetical protein 4311116 7564279 JTY_3929 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646967.1 4309860 D 561275 CDS YP_002646968.1 224992278 7564280 4311204..4311515 1 NC_012207.1 hypothetical protein 4311515 7564280 JTY_3930 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646968.1 4311204 D 561275 CDS YP_002646969.1 224992279 7564281 4311518..4312369 1 NC_012207.1 hypothetical protein 4312369 7564281 JTY_3931 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646969.1 4311518 D 561275 CDS YP_002646970.1 224992280 7564282 4312408..4312959 1 NC_012207.1 hypothetical protein 4312959 7564282 JTY_3932 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646970.1 4312408 D 561275 CDS YP_002646971.1 224992281 7564283 4312952..4314673 1 NC_012207.1 Differs from Rv3868 by 1aa, V243A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4314673 7564283 JTY_3933 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646971.1 4312952 D 561275 CDS YP_002646972.1 224992282 7564284 4314677..4316119 1 NC_012207.1 hypothetical protein 4316119 7564284 JTY_3934 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646972.1 4314677 D 561275 CDS YP_002646973.1 224992283 7564285 4316119..4318362 1 NC_012207.1 hypothetical protein 4318362 7564285 JTY_3935 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646973.1 4316119 D 561275 CDS YP_002646974.1 224992284 7564286 4318465..4319937 1 NC_012207.1 Differs from Rv3871 and Mb3901 by deletion of 101 codons after codon 480 due to BCG-specific RD1 deletion; hypothetical protein 4319937 7564286 JTY_3936 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646974.1 4318465 D 561275 CDS YP_002646975.1 224992285 7564287 complement(4320380..4320727) 1 NC_012207.1 hypothetical protein 4320727 7564287 JTY_3937 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646975.1 4320380 R 561275 CDS YP_002646976.1 224992286 7564288 complement(4320724..4322106) 1 NC_012207.1 Differs from Rv3881c by 7 codon stretch due to 1bp deletion and 1 bp insertion in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical alanine and glycine rich protein 4322106 7564288 JTY_3938 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine and glycine rich protein YP_002646976.1 4320724 R 561275 CDS YP_002646977.1 224992287 7564289 complement(4322213..4323601) 1 NC_012207.1 hypothetical protein 4323601 7564289 JTY_3939 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646977.1 4322213 R 561275 CDS YP_002646978.1 224992288 7564290 complement(4323598..4324938) 1 NC_012207.1 Differs from Rv3883c by 1aa, A37T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; protease 4324938 7564290 JTY_3940 Mycobacterium bovis BCG str. Tokyo 172 protease YP_002646978.1 4323598 R 561275 CDS YP_002646979.1 224992289 7564291 complement(4325160..4327019) 1 NC_012207.1 Differs from Rv3884c by 1aa, G215E in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; CbxX/CfqX family protein 4327019 7564291 JTY_3941 Mycobacterium bovis BCG str. Tokyo 172 CbxX/CfqX family protein YP_002646979.1 4325160 R 561275 CDS YP_002646980.1 224992290 7564292 complement(4327089..4328702) 1 NC_012207.1 Differs from Rv3885c by 1aa, P133L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4328702 7564292 JTY_3942 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646980.1 4327089 R 561275 CDS YP_002646981.1 224992291 7564293 complement(4328699..4330351) 1 NC_012207.1 alanine and proline rich protease 4330351 7564293 JTY_3943 Mycobacterium bovis BCG str. Tokyo 172 alanine and proline rich protease YP_002646981.1 4328699 R 561275 CDS YP_002646982.1 224992292 7564294 complement(4330336..4331865) 1 NC_012207.1 transmembrane protein 4331865 7564294 JTY_3944 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002646982.1 4330336 R 561275 CDS YP_002646983.1 224992293 7564295 complement(4331862..4332524) 1 NC_012207.1 Has no counterpart in Mycobacterium bovis owing to deletion of 2405bp between positions 4307384..4307385; hypothetical protein 4332524 7564295 JTY_3945 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646983.1 4331862 R 561275 CDS YP_002646984.1 224992294 7564296 complement(4332521..4332886) 1 NC_012207.1 Has no counterpart in Mycobacterium bovis owing to deletion of 2405bp between positions 364165-364166; hypothetical protein 4332886 7564296 JTY_3946 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646984.1 4332521 R 561275 CDS YP_002646985.1 224992295 7564297 complement(4332980..4333810) 1 NC_012207.1 In Mycobacterium bovis, a deletion of 2406 bases leads to the loss of the NH2 part of Rv3887c, the entire Rv3888c and the COOH part of Rv3889c compared to Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur; hypothetical protein 4333810 7564297 JTY_3947 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646985.1 4332980 R 561275 CDS YP_002646986.1 224992296 7564298 complement(4333818..4334192) 1 NC_012207.1 In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and in Mycobacterium bovis, a frameshift due to a single base deletion (C-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (124 aa versus 95 aa); EsaT-6 like protein 11 4334192 esxC 7564298 esxC Mycobacterium bovis BCG str. Tokyo 172 EsaT-6 like protein 11 YP_002646986.1 4333818 R 561275 CDS YP_002646987.1 224992297 7562874 complement(4334228..4334551) 1 NC_012207.1 Differs from Rv3891c by 1aa, A49T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4334551 esxD 7562874 esxD Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646987.1 4334228 R 561275 CDS YP_002646988.1 224992298 7562875 complement(4334662..4335861) 1 NC_012207.1 Differs from Rv3892c by 2aa, K19T, I206M and from Mb3921c by 1aa I206M in BCG Pasteur and BCG Tokyo; PPE family protein 4335861 PPE69 7562875 PPE69 Mycobacterium bovis BCG str. Tokyo 172 PPE family protein YP_002646988.1 4334662 R 561275 CDS YP_002646989.1 224992299 7560800 complement(4335940..4336173) 1 NC_012207.1 PE family protein 4336173 PE36 7560800 PE36 Mycobacterium bovis BCG str. Tokyo 172 PE family protein YP_002646989.1 4335940 R 561275 CDS YP_002646990.1 224992300 7561734 complement(4336440..4338125) 1 NC_012207.1 In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-C), splits Rv3894c into 2 parts; hypothetical protein 4338125 7561734 JTY_3952 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646990.1 4336440 R 561275 CDS YP_002646991.1 224992301 7564299 complement(4338130..4340631) 1 NC_012207.1 In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-C), splits Rv3894c into 2 parts. Differs from first part of Rv3984c by 1aa, P258R in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 4340631 7564299 JTY_3953 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646991.1 4338130 R 561275 CDS YP_002646992.1 224992302 7564300 complement(4340632..4342119) 1 NC_012207.1 Differs from Rv3895c by 1aa, G356D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4342119 7564300 JTY_3954 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646992.1 4340632 R 561275 CDS YP_002646993.1 224992303 7564301 complement(4342163..4343029) 1 NC_012207.1 Differs from Rv3896c by 3aa, G83D, V186I, K193Q, and by frameshift due to 1bp deletion leading to shorter product (288 aa versus 302 aa) in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4343029 7564301 JTY_3955 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646993.1 4342163 R 561275 CDS YP_002646994.1 224992304 7564302 complement(4343179..4344168) 1 NC_012207.1 In Mycobacterium tuberculosis, Rv3898c and Rv3897c exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (T-C) leads to a single product; hypothetical protein 4344168 7564302 JTY_3956 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646994.1 4343179 R 561275 CDS YP_002646995.1 224992305 7564303 complement(4344330..4345211) 1 NC_012207.1 In Mycobacterium tuberculosis, Rv3899c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur , and BCG Tokyo, a frameshift due to a single base deletion (C-*) splits Rv3899c into 2 parts, Mb3928c and Mb3929c with the former being the more likely product; hypothetical protein 4345211 7564303 JTY_3957 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646995.1 4344330 R 561275 CDS YP_002646996.1 224992306 7564305 complement(4345555..4346490) 1 NC_012207.1 Differs from Rv3900c by 1aa, A18P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical alanine rich protein 4346490 7564305 JTY_3959 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine rich protein YP_002646996.1 4345555 R 561275 CDS YP_002646997.1 224992307 7564306 complement(4346599..4346994) 1 NC_012207.1 Differs from Rv3901c by 1aa, W21L, and frameshift due to 2bp deletion at 3'-end, and from Mb3931c by frameshift only in BCG Pasteur and BCG Tokyo; hypothetical protein 4346994 7564306 JTY_3960 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646997.1 4346599 R 561275 CDS YP_002646998.1 224992308 7564307 complement(4347545..4348075) 1 NC_012207.1 hypothetical protein 4348075 7564307 JTY_3961 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002646998.1 4347545 R 561275 CDS YP_002646999.1 224992309 7564308 complement(4348072..4350612) 1 NC_012207.1 hypothetical alanine and proline rich protein 4350612 7564308 JTY_3962 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine and proline rich protein YP_002646999.1 4348072 R 561275 CDS YP_002647000.1 224992310 7564309 complement(4350617..4350889) 1 NC_012207.1 Differs from Rv3904c by 1aa, V82M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; EsaT-6 like protein 12 4350889 esxE 7564309 esxE Mycobacterium bovis BCG str. Tokyo 172 EsaT-6 like protein 12 YP_002647000.1 4350617 R 561275 CDS YP_002647001.1 224992311 7562876 complement(4351038..4351211) 1 NC_012207.1 In Mycobacterium bovis, and Mycobacteium bovis BCG Pasteur, and BCG Tokyo, a single base transition (G-A) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (57 aa versus 103 aa); EsaT-6 like protein 13 4351211 esxF 7562876 esxF Mycobacterium bovis BCG str. Tokyo 172 EsaT-6 like protein 13 YP_002647001.1 4351038 R 561275 CDS YP_002647002.1 224992312 7562877 complement(4351277..4351786) 1 NC_012207.1 hypothetical protein 4351786 7562877 JTY_3965 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002647002.1 4351277 R 561275 CDS YP_002647003.1 224992313 7564310 complement(4351811..4353253) 1 NC_012207.1 poly(A) polymerase 4353253 pcnA 7564310 pcnA Mycobacterium bovis BCG str. Tokyo 172 poly(A) polymerase YP_002647003.1 4351811 R 561275 CDS YP_002647004.1 224992314 7562524 4353629..4354375 1 NC_012207.1 hypothetical protein 4354375 7562524 JTY_3967 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002647004.1 4353629 D 561275 CDS YP_002647005.1 224992315 7564311 4354372..4356780 1 NC_012207.1 Differs from Rv3909 by 3aa, R7G, S399N, V538A and from Mb3939 by 1aa G25A in BCG Pasteur and BCG Tokyo; hypothetical protein 4356780 7564311 JTY_3968 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002647005.1 4354372 D 561275 CDS YP_002647006.1 224992316 7564312 4356777..4360331 1 NC_012207.1 Differs from Rv3910 by 1aa, A480V in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; transmembrane protein 4360331 7564312 JTY_3969 Mycobacterium bovis BCG str. Tokyo 172 transmembrane protein YP_002647006.1 4356777 D 561275 CDS YP_002647007.1 224992317 7564313 4360366..4360956 1 NC_012207.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase; RNA polymerase sigma factor SigM 4360956 sigMa 7564313 sigMa Mycobacterium bovis BCG str. Tokyo 172 RNA polymerase sigma factor SigM YP_002647007.1 4360366 D 561275 CDS YP_002647008.1 224992318 7561798 4361049..4361813 1 NC_012207.1 hypothetical alanine rich protein 4361813 7561798 JTY_3972 Mycobacterium bovis BCG str. Tokyo 172 hypothetical alanine rich protein YP_002647008.1 4361049 D 561275 CDS YP_002647009.1 224992319 7564314 4361907..4362914 1 NC_012207.1 Differs from Rv3913 by 1aa, G57D; thioredoxin reductase 4362914 trxB2 7564314 trxB2 Mycobacterium bovis BCG str. Tokyo 172 thioredoxin reductase YP_002647009.1 4361907 D 561275 CDS YP_002647010.1 224992320 7561640 4362911..4363261 1 NC_012207.1 thioredoxin 4363261 trxC 7561640 trxC Mycobacterium bovis BCG str. Tokyo 172 thioredoxin YP_002647010.1 4362911 D 561275 CDS YP_002647011.1 224992321 7561641 4363371..4364591 1 NC_012207.1 hydrolase 4364591 7561641 JTY_3975 Mycobacterium bovis BCG str. Tokyo 172 hydrolase YP_002647011.1 4363371 D 561275 CDS YP_002647012.1 224992322 7564315 complement(4364612..4365346) 1 NC_012207.1 hypothetical protein 4365346 7564315 JTY_3976 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002647012.1 4364612 R 561275 CDS YP_002647013.1 224992323 7564316 complement(4365636..4366670) 1 NC_012207.1 chromosome partitioning protein 4366670 parB 7564316 parB Mycobacterium bovis BCG str. Tokyo 172 chromosome partitioning protein YP_002647013.1 4365636 R 561275 CDS YP_002647014.1 224992324 7562517 complement(4366667..4367710) 1 NC_012207.1 chromosome partitioning protein 4367710 parA 7562517 parA Mycobacterium bovis BCG str. Tokyo 172 chromosome partitioning protein YP_002647014.1 4366667 R 561275 CDS YP_002647015.1 224992325 7562516 complement(4367707..4368381) 1 NC_012207.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 4368381 gidB 7562516 gidB Mycobacterium bovis BCG str. Tokyo 172 16S rRNA methyltransferase GidB YP_002647015.1 4367707 R 561275 CDS YP_002647016.1 224992326 7561915 complement(4368513..4369076) 1 NC_012207.1 Differs from Rv3920c by 1aa, W110R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4369076 7561915 JTY_3980 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002647016.1 4368513 R 561275 CDS YP_002647017.1 224992327 7564317 complement(4369148..4370248) 1 NC_012207.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 4370248 7564317 JTY_3981 Mycobacterium bovis BCG str. Tokyo 172 inner membrane protein translocase component YidC YP_002647017.1 4369148 R 561275 CDS YP_002647018.1 224992328 7564318 complement(4370232..4370594) 1 NC_012207.1 hypothetical protein 4370594 7564318 JTY_3982 Mycobacterium bovis BCG str. Tokyo 172 hypothetical protein YP_002647018.1 4370232 R 561275 CDS YP_002647019.1 224992329 7564319 complement(4370591..4370968) 1 NC_012207.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 4370968 rnpA 7564319 rnpA Mycobacterium bovis BCG str. Tokyo 172 ribonuclease P YP_002647019.1 4370591 R 561275 CDS YP_002647020.1 224992330 7561589 complement(4370965..4371108) 1 NC_012207.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 4371108 rpmH 7561589 rpmH Mycobacterium bovis BCG str. Tokyo 172 50S ribosomal protein L34 YP_002647020.1 4370965 R 561275 CDS