-- dump date   	20140619_151607
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_002643051.1	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.
YP_002643052.1	binds the polymerase to DNA and acts as a sliding clamp
YP_002643053.1	Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_002643054.1	Differs from Mb0004 by 1aa, S16L in BCG Pasteur and BCG Tokyo
YP_002643055.1	negatively supercoils closed circular double-stranded DNA
YP_002643056.1	negatively supercoils closed circular double-stranded DNA
YP_002643057.1	Differs from Mb0007 by 1aa, I272V in BCG Pasteur and BCG Tokyo
YP_002643058.1	Differs from Rv0008c by 1aa, P145S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643060.1	In Mycobacterium bovis BCG Pasteur and BCG Tokyo, and Mycobacterium bovis, a single base deletion (g-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (111 aa versus 141 aa)
YP_002643061.1	integral membrane protein involved in inhibition of the Z-ring formation
YP_002643062.1	Differs from Rv0012 by 2aa, E105K, R233C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643063.1	aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity
YP_002643068.1	Differs from Rv0018c by 3aa, L3R, A455S, S463P in Mcobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643070.1	Differs from Mb0020c by 2aa, G47R, Y250H, and from Rv0020c by 3aa, G222D, C298Y, Q378R, and deletion of 6aa (EQRGYP) at position 246 in BCG Pasteur and BCG Tokyo
YP_002643071.1	Differs from Rv0021c by 1aa, P277A in Mcobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643074.1	In Mycobacterium tuberculosis strain H37Rv, and other mycobacteria, Rv0024 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (C-*) splits Rv0024 into 2 parts
YP_002643075.1	Differs from Rv0025 by 1aa, L73P in Mcobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643076.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 4 bp insertion (*-ATCG) leads to a longer protein with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (477 aa versus 448 aa). Differs from Rv0026 by 1aa, P93Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643079.1	Differs from Rv0029 by 1aa, N190H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643085.1	fatty-acid-CoA synthetase, fatty-acid-CoA synthase
YP_002643086.1	Differs from Mb0037c and Rv0036c by 1aa in BCG Pasteur and BCG Tokyo, L186P in BCG Pasteur, and at C-terminal end due to frameshift resulting from 1 bp deletion at position equivalent to Mycobacterium tuberculosis H37Rv, 39228-39228, after codon 202 in BCG Pasteur and Tokyo.
YP_002643089.1	Differs from Rv0039c by 1aa, F24C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643090.1	proline rich 28 kDa antigen
YP_002643091.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_002643092.1	MarR-FAMILY
YP_002643093.1	probably GntR-family
YP_002643096.1	Differs from Mb0047c by 1aa, T120I, and from Rv0046c by 2aa, T120I, G190R
YP_002643098.1	Differs from Rv0048c by 1aa, A250V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643100.1	In Mycobacterium bovis BCG Pasteur and BCG Tokyo, insertion of 3 codons after position 632 leads to a slightly longer product compared to its homologs in Mycobacterium tuberculosis strain H37Rv (681 aa versus 678 aa) and Mycobacterium bovis AF2122/97 (681 aa versus 680 aa). In addition, differs from Rv0050 by 1aa, L6P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002643103.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_002643104.1	binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA
YP_002643105.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_002643106.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_002643108.1	unwinds double stranded DNA; these Mycobacterial enzymes appear to contain inteins
YP_002643132.1	Differs from Mb0063 by 1aa, A72D, and from Rv0062 by 2aa, A72D, V106I in BCG Pasteur and BCG Tokyo; endoglucanase
YP_002643134.1	Differs from Mb0065 by 1aa, T435I, and from Rv0064 by 4aa, T435I, D457G, F550V, P906R in BCG Pasteur and BCG Tokyo
YP_002643135.1	Differs from Rv0064A by 1aa, V48A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643137.1	Differs from Rv0066c by 1aa, N117K in in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643138.1	possibly TetR-family
YP_002643139.1	Differs from Rv0068 by 1aa, L214V in Mycobacterium bovis, Mycobacterium tuberculosis CDC1551, BCG Pasteur, and BCG Tokyo.
YP_002643141.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_002643142.1	In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 45 bp insertion (5 copies of VDP repeat) leads to longer products compared to its homologs in Mycobacterium tuberculosis strain H37Rv (250 aa versus 235 aa) and Mycobacterium bovis (250 aa versus 238 aa)
YP_002643144.1	In Mycobacterium tuberculosis strain H37Rv, Rv0073 exists as a single gene as in Mycobacterium bovis BCG Pasteur and BCG Tokyo. In Mycobacterium bovis, a frameshift due to a single base deletion (A-*) splits Rv0073 into 2 parts, Mb0074 and Mb0075
YP_002643146.1	Differs from Rv0075 and Mb0077 by 1aa, G326D in BCG Pasteur and BCG Tokyo
YP_002643149.1	Differs from Rv0078 by 1aa, V113I in BCG Pasteur and BCG Tokyo
YP_002643153.1	Differs from Mb0083 by 1aa, C35R, and from Rv0080 by 2aa, C35R, V60G in BCG Pasteur. Differs from Rv0080 by 1aa, V60G in BCG Tokyo. without qualifier
YP_002643155.1	Differs from Rv0082 by 1aa, R74Q in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643156.1	In Mycobacterium bovis, a single base transversion (a-t) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (642 aa versus 640 aa). Differs from Mb0086 by 1aa, A177V in BCG Pasteur and BCG Tokyo.
YP_002643159.1	Differs from Rv0086 by 1aa, T118M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643160.1	Differs from Rv0087 by 1aa, I230V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643165.1	Differs from Rv0092 by 1aa, A3T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643166.1	Differs from Rv0093c by 1aa, R22C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643167.1	Differs from Rv0094c by 3aa, D256E, W296R, K315E in BCG Pasteur and BCG Tokyo
YP_002643168.1	In Mycobacterium tuberculosis strain H37Rv, Rv0095c and Rv1588 exist as separate genes in their respective positions. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 73 bp substitution leads to a single combined gene. Differs from Rv0095c by 5aa, E57D, T70S, V85A, V91G, A92Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643169.1	Differs from Rv0096 by 1aa, W182R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643172.1	activates fatty acids by binding to coenzyme A
YP_002643176.1	Differs from Rv0103c by 1aa, S22L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643178.1	required for 70S ribosome assembly
YP_002643180.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-T) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv differs from Rv0107c by 3aa, V136A, P1247S, S1327A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643182.1	Differs from Rv0109 by 1aa, G346R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643186.1	catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate
YP_002643187.1	Differs from Rv0114 by 1aa, R121G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643188.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-c) equivalent to Mycobacterium tuberculosis H37Rv position 139559, leads to shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. In addition, in Mycobacterium bovis, a single base insertion, at position equivalent to 138823, leads to a different NH2 part
YP_002643191.1	catalyzes the formation of formyl-CoA from oxalyl-CoA
YP_002643192.1	activates fatty acids by binding to coenzyme A
YP_002643193.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_002643197.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 180 bp insertion leads to a longer product in the 3' direction compared to its homolog in Mycobacterium tuberculosis strain H37Rv (538 aa versus 487 aa)
YP_002643200.1	Differs from Rv0127 by 1aa, P18S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643205.1	Differs from Mb0137c by 1aa, E147K in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643206.1	In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis AF2122/97, codon 161 is TAC and in Mycobacterium bovis BCG Pasteur and BCG Tokyo, TAA
YP_002643209.1	this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress
YP_002643210.1	Differs from Mb0143 by 1aa, D96G in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643211.1	Differs from Mb0144 by 1aa, R227H in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643215.1	Differs from Rv0143c by 1aa, L34F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643216.1	possibly TetR-family
YP_002643223.1	Differs from Rv0151c by 1aa, R26G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643225.1	Differs from Rv0153c by 1aa, G105D in BCG Pasteur and BCG Tokyo
YP_002643228.1	Differs from Rv0156 by 1aa, C2Y in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643230.1	possibly TetR-family
YP_002643231.1	Differs from Rv0159c by 1aa, T255P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643232.1	Differs from Rv0160c by 2aa, T116A, T211A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643234.1	Differs from Rv0162c and Mb0167c by 1aa, R41H in BCG Pasteur and BCG Tokyo
YP_002643237.1	In Mycobacterium tuberculosis strain H37Rv, Rv0165c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a 2bp insertion (*-CC) leads to a product with a different COOH terminus; probably GntR-family
YP_002643238.1	activates fatty acids by binding to coenzyme A
YP_002643241.1	Differs from Rv0169 by 2aa, A313S, S359P. Differs from Rv0169 by 2aa, A313S, S359P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643242.1	Differs from Rv0170 by 1aa, T179I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643243.1	Differs from Rv0171 by 1aa, D212E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643246.1	Differs from Rv0174 by 1aa, P370L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643248.1	Differs from Mb0182 by 1aa, S285N, and from Rv0176 by 3aa, S285N, S290Q, A291S in BCG Pasteur and BCG Tokyo
YP_002643251.1	Differs from Rv0179c by 1aa, H124R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643254.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
YP_002643258.1	Differs from Mb0192 by 1aa, S504I, and from Rv0186 by 2aa, S504I, R532P in BCG Pasteur and BCG Tokyo
YP_002643259.1	Differs from Rv0187 and Mb0193 by 1aa, V147A in BCG Pasteur and BCG Tokyo
YP_002643261.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_002643264.1	In Mycobacterium tuberculosis strain H37Rv, Rv0192 and Rv0192A exist as 2 genes with an overlap region. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-g) leads to a single product. Differs from Mb0198 by 1aa, A279V and from Rv0192 by 2aa, P113S, A279V in BCG Pasteur and BCG Tokyo
YP_002643265.1	Differs from Rv0193c and Mb0199c by 1aa, E417K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643266.1	Differs from Mb0200 by 1aa, I49V, and from Rv0194 by 2aa, T74M, M223T in BCG Pasteur and BCG Tokyo
YP_002643267.1	probably LuxR-family
YP_002643269.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transversion (T-G) introduces a stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (748 aa versus 762 aa). Differs from Rv0197 by 1aa, S378R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643275.1	Differs from Rv0203 and Mb0209 by 1aa, T88K in BCG Pasteur and BCG Tokyo
YP_002643276.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, the presence of a more likely start codon leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (427 aa versus 412 aa). Differs from Rv0204c by 1aa, L321V in BCG Pasteur and BCG Tokyo
YP_002643277.1	Differs from Rv0205 by 1aa, R72H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002643278.1	Differs from Rv0206c by 2aa, I384F, E466D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002643280.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_002643281.1	Differs from Rv0209 by 1aa, A162V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643282.1	Differs from Rv0210 by 1aa, T486A in Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002643283.1	catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP
YP_002643284.1	probably AsnC-family
YP_002643286.1	activates fatty acids by binding to coenzyme A
YP_002643287.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 29 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (388 aa versus 357 aa). Differs from Mb0221c by 1aa, S361A in BCG Pasteur and BCG Tokyo
YP_002643289.1	Differs from Rv0217c by 1aa T184P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643290.1	Differs from Rv0218 by 2aa, R316C, N413D
YP_002643293.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, and BCG Tokyo, RD10, a 1902 bp deletion leads to a shorter product with a different COOH part, compared to its homolog in Mycobacterium tuberculosis strain H37Rv (257 aa versus 469 aa). It also leads to the deletion of the next protein, echA1 (Rv0222) in BCG Pasteur and BCG Tokyo
YP_002643294.1	In mycobacterium bovis strain AF2122/97, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, RD10, a 1902 bp deletion, compared to Mycobacterium tuberculosis H37Rv, truncates Rv0221c and Rv0223c and removes Rv0222c. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base deletion at position equivalent to Mycobacterium tuberculosis H37Rv 267419-267419 (*-C) splits gene into two parts compared to its homologs in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis AF2122/97 (116 aa and 269 aa, versus 487 aa and 385 aa, respectively. Also has same 1 bp insertion, as Mycobacterium bovis AF2122/97, at position equivalent to Mycobacterium tuberculosis H37Rv base 266743. Deletion in Mycobacterium bovis, bovis BCG Pasteur, and BCG Tokyo of region RD10 leads to a different COOH part compared to Mycobacterium tuberculosis strain H37Rv. Maybe pseudogene.
YP_002643295.1	In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base deletion at position equivalent to Mycobacterium tuberculosis H37Rv2 267419-267419 (*-C) splits gene into two parts compared to its homologs in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis AF2122/97 (116 aa and 269 aa, versus 487 aa and 385 aa, respectively. Also has same 1 bp insertion, as Mycobacterium bovis AF2122/97, at position equivalent to Mycobacterium tuberculosis H37Rv2 base 266743. May be pseudogene
YP_002643296.1	Differs from Rv0224c by 1aa, L117F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643299.1	Differs from Rv0227c by 1aa, R29S, and from Mb0232c by 1aa, S392N in BCG Pasteur and BCG Tokyo
YP_002643302.1	Differs from Rv0230c by 1aa, E199D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643304.1	probably TetR/AcrR-family
YP_002643305.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_002643306.1	NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate
YP_002643308.1	Differs from Rv0236c by 3aa, V412M, A990T, G1080S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643310.1	Differs from Rv0237 by 1aa, L129V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643311.1	probably TetR-family
YP_002643313.1	Differs from Rv0240 by 1aa, S31A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643315.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_002643316.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_002643317.1	Differs from Mb0250c by 1aa, N503D and from Rv0244c by 3aa, R394K, A479E, N503D in BCG Pasteur and BCG Tokyo
YP_002643319.1	Differs from Mb0252 by 1aa, A129V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643320.1	catalyzes the fumarate and succinate interconversion; fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source
YP_002643321.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol
YP_002643325.1	fad flavoprotein
YP_002643327.1	cobinamide kinase, cobinamide phosphate guanylyltransferase
YP_002643328.1	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation
YP_002643330.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (C-T) leads to a truncated product in the 5' direction compared to Mycobacterium tuberculosis strain H37Rv (72 aa versus 124 aa)
YP_002643332.1	Differs from Rv0259c by 1aa, V182A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643333.1	catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane
YP_002643338.1	Differs from Rv0265c and Mb0271c by 1aa, C313Y in BCG Pasteur and BCG Tokyo
YP_002643343.1	activates fatty acids by binding to coenzyme A
YP_002643345.1	Differs from Mb0278c by 1aa, P164L in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643348.1	Differs from Rv0275c by 1aa, L24S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; possibly TetR-family
YP_002643351.1	Differs by 1 aa, Q24* from Rv0227A and Mb0351A in BCG Pasteur and BCG Tokyo
YP_002643352.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS3 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovs BCG Pasteur and BCG Tokyo, a large insertion leads to an extra copy of PE_PGRS3. Also, a frameshift due to single base deletion (T-*), splits this extra copy of PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b. Also differs from Mb0285c by an insertion of 144bp.
YP_002643353.1	In Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a insertion of 66 bp lead to a longer product than to the homolog Mycobacterium bovis (899 aa versus 877 aa). In Mycobacterium bovis, 2 deletions, one of 18 bp and the other of 66 bp, and part of a 2780 bp insertion , leads to a shorter product with a different 3' end compared to its homolog in Mycobacterium tuberculosis strain H37Rv (877 aa versus 957 aa)
YP_002643354.1	In Mycobacterium bovis BCG Pasteur, and BCG Tokyo, 2 insertionseach of 9 bp and a deletion of 9 bp, lead to a longer product compared to its homolog in Mycobacterium bovis (834 aa versus 831 aa). In Mycobacterium bovis, 2 deletions each of 9 bp (CCGCCGGCG-* and CCCGCCGGC-*), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (831 aa versus 837 aa)
YP_002643355.1	Differs from Rv0280 by 1 aa P337S in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002643357.1	Differs from Rv0282 by 1aa, A6E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002643359.1	Differs from Mb0292 by 1aa, A134T, and from Rv0284 by 2aa, A134T, R214P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643365.1	Differs from Rv0290 by 1aa, T400A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643367.1	Differs from Rv0292 by 1aa, D217N in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643368.1	Differs from Rv0293c and Mb0301c by 1aa, S263G in BCG Pasteur and BCG Tokyo
YP_002643369.1	catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate
YP_002643372.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (606 aa versus 591 aa)
YP_002643374.1	Differs from Mb0307 by 1aa, S13N in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643377.1	Differs from Mb0310 by 1aa A124V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably TetR/AcrR-family
YP_002643379.1	In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (G-*) leads to a shorter CDS (Mycobacterium bovis, BCG Pasteur, and BCG Tokyo) equivalent to the 3' end of Rv0304c/PPE5. Differs from Rv0304c by 3aa, S481G, F708S, A955T, and 5 codon in-frame deletion at position 503 in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002643380.1	In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base deletion (T-*) resulting in the absence of a stop codon leads to a longer product. The second part of this CDS shares homology with the 5' end of Rv0304c/PPE5. Differs from Mb0313c by in-frame deletion of 10 codons in BCG Pasteur and BCG Tokyo.
YP_002643387.1	Differs from Rv0312 by 2aa, G159S, L563P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643389.1	Differs from Rv0314c by 1aa, A184V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002643390.1	Differs from Rv0315 by 1aa, T260K in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643393.1	Differs from Rv0318c by 1aa, A223G in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643394.1	catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline
YP_002643396.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_002643398.1	Differs from Rv0323c by 1aa, G142S in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002643399.1	Differs from Rv0324 by 1aa, A168T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; possibly ArsR-family
YP_002643400.1	In Mycobacterium tuberculosis strain H37Rv, Rv0325 and Rv0326 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, the absence of a stop codon between Rv0325 and Rv0326 due to a single base transition (T-C) leads to single product
YP_002643401.1	Differs from Rv0327c by 1aa, Y100H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002643402.1	possibly TetR/AcrR-family
YP_002643403.1	Differs from Rv0329c by 1aa, S129W in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643406.1	Differs from Rv0332 by 1aa, G198E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643409.1	Differs from Rv0335c and Mb0340 by 1aa P131T in BCG Pasteur and BCG Tokyo
YP_002643410.1	broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor
YP_002643411.1	Differs from Rv0338c by 2aa, G506R, V621A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643415.1	Differs from by 2aa, S88N, Q481H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643418.1	In Mycobacterium bovis, a frameshift due to a single base deletion (A-*) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv in Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643423.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_002643424.1	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_002643425.1	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_002643426.1	MerR family
YP_002643427.1	In Mycobacterium tuberculosis strain H37Rv, PPE7 and PPE8 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 2 bp insertion (*-TA) resulting in the absence of a stop codon between the 2 genes, leads to a single product, and an altered C-terminus
YP_002643429.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_002643431.1	Differs from Rv0359 by 1aa, T252A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643434.1	Differs from Mb0362 by 1aa, V292A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002643435.1	catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate
YP_002643436.1	Differs from Rv0364 by 1aa, L193I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643440.1	Differs from Rv0368c by 1aa, H249R, and from Mb0375c by 1aa, G371S in BCG Pasteur and BCG Tokyo
YP_002643442.1	Differs from Rv0370c by 1aa, E201G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643444.1	Differs from Mb0379c by 1aa, G161S in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002643445.1	Differs from Rv0373c by 1aa, S122F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643449.1	Differs from Rv0377 by 1aa, R302P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably LysR-family
YP_002643454.1	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_002643458.1	Differs from Mb0393 by 1aa, D902A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably LuxR/UhpA-family
YP_002643459.1	In Mycobacterium tuberculosis strain H37Rv, Rv0388c and Rv0387c exist as 2 separate genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, 3 different base substitutions, the first of 14 bases, the second of 8 bases (TCTACAGT-GCTACAGG), and lastly of 28 bases, leads to a longer single product. Differs from Mb0394c by 1aa, T361A in BCG Pasteur and BCG Tokyo.
YP_002643460.1	non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis
YP_002643463.1	Differs from Rv0392c by 1aa, A241V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643466.1	Differs from Rv0395 by 1aa, A80V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002643473.1	In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (C-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b
YP_002643474.1	In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (C-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b. Differs from Rv0402c by 1aa, P451L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643476.1	activates fatty acids by binding to coenzyme A
YP_002643477.1	In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to single base insertion (*-G) splits pks6 into 2 parts,pks6a and pks6b
YP_002643478.1	In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis, a frameshift due to single base insertion (*-G), splits pks6 into 2 parts, pks6a and pks6b. Differs from Mb0413 by 1aa, M921V in BCG Pasteur and BCG Tokyo
YP_002643481.1	catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate
YP_002643482.1	AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA
YP_002643485.1	Differs from Rv0412c by 1aa, Y355D in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002643486.1	7,8-dihydro-8-oxoguanine-triphosphatase, 8-oxo-dGTPase, dGTP pyrophosphohydrolase
YP_002643487.1	Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate
YP_002643488.1	Differs from Mb0423 by 1aa, A158V in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002643489.1	with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate
YP_002643490.1	functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate
YP_002643492.1	Differs from Rv0419 by 2aa, T73A, T297A, and from Mb0427 by 1aa, T73A in BCG Pasteur and BCG Tokyo
YP_002643493.1	Differs from Mb0428c by 1aa, G21E in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo
YP_002643495.1	catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine
YP_002643496.1	required for the synthesis of the hydromethylpyrimidine moiety of thiamine
YP_002643498.1	Differs from Rv0425c by 1aa, A222E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002643501.1	Differs from Rv0428c by 1aa G149D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002643502.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_002643504.1	Differs from Rv0431 by 2aa, G38V, A87T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002643506.1	ATP-dependent carboxylate-amine ligase
YP_002643507.1	Differs from Rv0434 by 1aa, A190T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002643509.1	Differs from Rv0436c by 1aa, V167G in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis BCG Pasteur, and BCVG Tokyo
YP_002643510.1	catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine
YP_002643511.1	Differs from Rv0438c by 1aa, I15M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002643513.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_002643515.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (G-A) creates an in-frame stop at codon 8, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (479 aa versus 487 aa). Differs from Mb0450c by 1aa, T214K, and from Rv0442c by 2aa, E23K, T214K in BCG Pasteur and BCG Tokyo.
YP_002643517.1	Differs from Rv0444c by 2aa, D107G, E184G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002643518.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins
YP_002643523.1	Differs from Mb0458c by 1aa, A314T in BCG Pasteur and BCG Tokyo
YP_002643529.1	catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002643531.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a possible RBS upstream leads to an earlier start resulting in a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (676 aa versus 673 aa)
YP_002643536.1	E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component
YP_002643539.1	Differs from Rv0465c by 2aa, D36N, R106C, and from Mb0474c by 1aa, R326Q in BCG Pasteur and BCG Tokyo
YP_002643542.1	converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA
YP_002643544.1	Differs from Rv0470c, Mb0479c by 1aa, P154T in Mycobacterium bovis BCG Tokyo.
YP_002643547.1	Differs from Rv0472c and Mb0482c by 1aa, D162G in BCG Pasteur and BCG Tokyo; possibly TetR-family
YP_002643548.1	Differs from Rv0473 by 1aa, R5K in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643553.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate
YP_002643555.1	In Mycobacterium bovis, a 56 bp deletion results in a different NH2 part and leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (311 aa versus 340 aa)
YP_002643557.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_002643559.1	Differs from Rv0484c by 1aa, L140I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643564.1	2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate
YP_002643565.1	Differs from Rv0490 and Mb0500 by 1aa, S109F
YP_002643566.1	Differs from Rv0491 and Mb0501 by 1aa, T18A in BCG Pasteur, by 2aa, T18A, C219R in BCG Tokyo.; probably LuxR-family
YP_002643567.1	Differs from Rv0492c by 1aa, F520L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643569.1	Differs from Rv0493c by 1aa, G174S in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002643570.1	probably GntR-family
YP_002643576.1	catalyzes the formation of L-proline from pyrroline-5-carboxylate
YP_002643584.1	Differs from Mb0519 by 1aa, D119H, and from Rv0507 by 3aa, H426R, Y509D, C722S in BCG Pasteur and BCG Tokyo
YP_002643586.1	catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins
YP_002643587.1	transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis
YP_002643589.1	catalyzes the formation of porphobilinogen from 5-aminolevulinate
YP_002643591.1	Differs from Mb0527 and Rv0514 by 1aa, G23A in BCG Pasteur and BCG Tokyo
YP_002643594.1	Differs from Rv0517 by 1aa, G394D in BCG Pasteur and BCG Tokyo
YP_002643599.1	4-amino butyrate transport carrier
YP_002643601.1	Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway
YP_002643609.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS6 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-T) splits PE_PGRS6 into 2 parts, PE_PGRS6a and PE_PGRS6b, resulting in PE_PGRS6a having a different COOH part. There is also a 84 bp and a 9 bp (*-cggggccgg) insertion in PE_PGRS6a
YP_002643610.1	FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
YP_002643611.1	catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate
YP_002643612.1	Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate
YP_002643615.1	Differs from Rv0538 by 1aa, P228R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643618.1	Differs from Rv0541c by 1aa, V226I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643622.1	Differs from Rv0545c by 1aa, S49P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643625.1	catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA
YP_002643626.1	In Mycobacterium tuberculosis strain H37Rv, Rv0549c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (T-*), splits Rv0549c into 2 parts
YP_002643628.1	activates fatty acids by binding to coenzyme A
YP_002643629.1	Differs from Rv0552 and Mb0567 by 1aa, T144I in Mycobacterium bovis BCG Pasteur
YP_002643630.1	catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate
YP_002643631.1	non-haem peroxidase
YP_002643632.1	SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis
YP_002643633.1	Differs from Rv0556 by 1aa, R15L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643635.1	Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone
YP_002643640.1	metalloprotease
YP_002643641.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_002643643.1	nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription
YP_002643644.1	Differs from Rv0567 by 1aa, L201F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643645.1	Differs from Rv0568 and Mb0583 by 1aa, E120G in BCG Pasteur and BCG Tokyo
YP_002643647.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (C-*) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_002643648.1	Differs from Rv0571c and Mb0586c by 1aa, L258F in BCG Pasteur and BCG Tokyo
YP_002643649.1	Differs from Rv0572c by 1aa, L31F in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643650.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate
YP_002643651.1	Differs from Rv0574c by 1aa, K4N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643652.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-C) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_002643653.1	Differs from Rv0576 by 1aa, H233R in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; possibly ArsR-family
YP_002643655.1	Differs from Rv0578c and from Mb0593c by 3aa, there are deleted in Mycobacterium bovis BCG Pasteur.
YP_002643661.1	Differs from Rv0584 by 1aa G90D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643662.1	Differs from Rv0585c by 1aa V438I and from Mb0600c by 2aa M150I and V438I in BCG Pasteur and BCG Tokyo
YP_002643663.1	GntR-family
YP_002643666.1	Differs from Rv0589 by 1aa S51F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643667.1	In Mycobacterium tuberculosis strain H37Rv, mce2B and Rv0590A are 2 genes, most likely to be linked. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, an in-frame insertion of a single base (*-G) leads to a single product
YP_002643668.1	Differs from Rv0591 by 2aa M49T and N398T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643669.1	In Mycobacterium tuberculosis strain H37Rv, mce2D exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a frameshift occurs in a strech of C (7 for H37Rv, 8 for Mycobactrium bovis and 9 for Mycobacterium bovis BCG). This leads to mceDa genes with different COOH parts and a remnant mc2Db pseudogene
YP_002643670.1	In Mycobacterium bovis, a single base transition (C-T) introducing a stop codon, leads to the formation of a truncated product compared to its homolog in Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (188 aa versus 402 aa)
YP_002643678.1	first part
YP_002643679.1	Differs from Rv0602c by 1aa I28V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643680.1	Differs from Mb0619 by 2aa P77A and E96K in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo
YP_002643681.1	Differs from Rv0604 by 1aa P180S in BCG Pasteur and BCG Tokyo
YP_002643688.1	Differs from Rv0610c by 1aa S103N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643697.1	In Mycobacterium tuberculosis strain H37Rv, galT is split into 2 parts, galT' and 'galT. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, an in-frame insertion of a single base (*-A) leads to a single product. Differs from Mb0635 by 1aa R183G and from Rv0619 by 1aa A397T in BCG Pasteur and BCG Tokyo
YP_002643698.1	catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism
YP_002643699.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (A-G) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (385 aa versus 354 aa)
YP_002643707.1	Differs from Rv0629c by 1aa A536T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643708.1	In Mycobacterium tuberculosis strain H37Rv, recB exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (G-*) splits recB into 2 parts, recBa and recBb. Differs from Mb0647c by 1aa H514R and from Rv0630c by 3aa L74V, H514R and F811V in BCG Pasteur and BCG Tokyo
YP_002643709.1	Differs from Rv0631c by 1aa E329G and from Mb0648c by 1aa P858L in BCG Pasteur and BCG Tokyo
YP_002643710.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002643711.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 9 bp deletion (CGGGTGCGC-*) leads to shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (Rv0633c) (276 aa versus 279 aa)
YP_002643714.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif
YP_002643715.1	functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II
YP_002643716.1	functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II
YP_002643717.1	functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II
YP_002643718.1	forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_002643719.1	Modulates Rho-dependent transcription termination
YP_002643720.1	binds directly to 23S ribosomal RNA
YP_002643721.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_002643722.1	Differs from Rv0642c by 1aa L95F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643723.1	Differ from Rv0643c by 1aa, D98G in BCG Pasteur.
YP_002643724.1	Differs from Rv0644c by 1aa L114R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643727.1	Differs from Rv0647c by 1aa T293A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643728.1	Differs from Rv0648 by 1aa L200S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643731.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_002643732.1	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_002643733.1	probably TetR-family
YP_002643738.1	Differs from Rv0658c by 1aa P75L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002643743.1	Differs from Rv0663 by 1aa G349D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643747.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_002643748.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_002643749.1	Differs from Rv0669c by 1aa P146S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643750.1	Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues
YP_002643753.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002643755.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002643756.1	Differs from Rv0676c by 2aa I794T and V948I in Mycobacterium bovis BCG Pasteur, by 3aa I794T, I906V, V948I in Mycobacterium bovis BCG Tokyo.
YP_002643761.1	possibly TetR-family
YP_002643762.1	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_002643763.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_002643764.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_002643765.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_002643766.1	Differs from Rv0686 by 1aa S82I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643767.1	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_002643774.1	cytochrome
YP_002643778.1	In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718
YP_002643779.1	In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718
YP_002643781.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_002643782.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_002643783.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_002643784.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_002643785.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_002643786.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_002643787.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_002643788.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_002643789.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_002643790.1	one of the stabilizing components for the large ribosomal subunit
YP_002643791.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_002643792.1	In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, atsA exists as a single gene. In Mycobacterium bovis, a single base transversion (G-T), introducing a stop codon, splits atsA into 2 parts, atsAa and atsAb
YP_002643795.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_002643796.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_002643797.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_002643798.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif
YP_002643799.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_002643800.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_002643801.1	binds 5S rRNA along with protein L5 and L25
YP_002643802.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_002643803.1	L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7
YP_002643804.1	late assembly protein
YP_002643805.1	endopeptidase IV
YP_002643808.1	catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate
YP_002643809.1	Differs from Rv0728c by 1aa H242R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643810.1	Differs from Rv0729 by 2aa P134L and S439 in Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002643813.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_002643814.1	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_002643815.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn
YP_002643816.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein regulates polyketide synthases and  or membrane proteins
YP_002643820.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 2 bp insertion (*-CG) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (282 aa versus 268 aa)
YP_002643827.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, two 48 bp deletions, and a 138 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (797 aa versus 783 aa). Differs from Mb0767 by 1aa S597N in BCG Pasteur and BCG Tokyo
YP_002643828.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, insertions of 168 bp and 105 bp, a 11 bp for 71 bp substitution, and a 9 bp deletion (CGGCAACGG-*), leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (909 aa and 893 aa versus 801 aa). In addition, in Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 48 bp deletion compared to Mycobacterium bovis and Mycobacterium tuberculosis strain H37Rv. occurs
YP_002643834.1	Differs from Rv0752c by 2aa A69V and V186I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643835.1	Differs from Mb0775c by 1aa V442G in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643837.1	Differs from Rv0755c by 1aa K545R in BCG Pasteur and BCG Tokyo
YP_002643841.1	Differs from Rv0755c by 2aa I71G, L172P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643852.1	Differs from Rv0769 by 1aa V55A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643853.1	Differs from Mb0793 by 1aa V126G in BCG Pasteur and BCG Tokyo
YP_002643855.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_002643856.1	gamma-glutamyltranspeptidase
YP_002643857.1	Differs from Rv0774c by 1aa A219S and from Mb0797c by 1aa D142A in BCG Pasteur and BCG Tokyo
YP_002643860.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_002643863.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_002643864.1	In Mycobacterium tuberculosis strain H37Rv, ptrB is split into 2 genes, ptrBa and ptrBb, due to a frameshift. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 2 bp insertion (*-gc) leads to a single product; oligopeptidase B
YP_002643867.1	In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (T-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808
YP_002643868.1	In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo, a frameshift due to a single base deletion (T-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808
YP_002643870.1	Differs from Rv0787 by 1aa H269Y in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643871.1	With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway
YP_002643872.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_002643876.1	probably GntR-family
YP_002643878.1	In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (a-*) splits Rv0794c into 2 parts
YP_002643879.1	In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (a-*) splits Rv0794c into 2 parts
YP_002643882.1	catalyzes the removal of amino acids from the N termini of peptides
YP_002643885.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_002643890.1	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_002643891.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_002643894.1	catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate
YP_002643900.1	Differs from Rv0818 by 1aa P97L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643902.1	In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis phoT exists as a single gene. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a frameshift due to a single base deletion (G-*), splits phoT into two parts phoTa and phoTb. Differs from Rv0820 by 1aa L35F in BCG Pasteur and BCG Tokyo
YP_002643904.1	Differs from Rv0822c by 1aa P89H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643905.1	Differs from Rv0823c by 2aa C130G and L330F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643908.1	Differs from Rv0826 by 1aa Q294R and Mb0849 by 1aaE97G in BCG Pasteur and BCG Tokyo
YP_002643911.1	Differs from Rv0829 by 1aa G80A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643914.1	In Mycobacterium bovis BCG Pasteur and BCG Tokyo, PE-PGRS13 exist as a single gene. In Mycobacterium tuberculosis and Mycobacterium bovis, it is splitted in 2 genes PE-PGRS12 and PE-PGRS13
YP_002643915.1	In Mycobacterium bovis, deletions of 143 bp and 9 bp (cgccgttgc-*), leads to a shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (831 aa versus 882 aa)
YP_002643916.1	Differs from Rv0835 by 1aa G162D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643917.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (a-g) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (240 aa versus 217 aa)
YP_002643919.1	In Mycobacterium bovis, a 6bp insertion (*-CGGCCC) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (258 aa versus 256 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 12bp insertion (compared to its homolog in Mycobacterium tuberculosis strain H37Rv) and a 6bp insertion (compared to its homolog in Mycobacterium bovis) leads to an even longer product (260 aa)
YP_002643922.1	Differs from Rv0841 by 1aa F29V in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002643924.1	Differs from Rv0843 by 1aa G191D and from Mb0866 by 1aa A309D in BCG Pasteur and BCG Tokyo
YP_002643925.1	Differs from Mb0867c by 1aa A73P in BCG Pasteur and BCG Tokyo
YP_002643926.1	Differs from Rv0845 by 1aa E219A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643927.1	Differs from Mb0869c by 1aa Y411H in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643928.1	Differs from Rv0847 by 1aa V128A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643929.1	Differs from Rv0848 by 1aa S93G, and from Mb0871 by 1aa V137G in BCG Pasteur and BCG Tokyo
YP_002643932.1	Differs from Rv0851c by 1aa G59S and from Mb0874c by 1aa V84F in BCG Pasteur and BCG Tokyo
YP_002643940.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_002643941.1	Differs from Rv0860 by 1aa T701A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643942.1	Differs from Rv0861c by 1aa A258V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643943.1	Differs from Rv0862c by 2aa F224L and S749L, and from Mb0885c by 1aa F224L in BCG Pasteur and BCG Tokyo
YP_002643945.1	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis
YP_002643948.1	In Mycobacterium bovis, a 240 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (327 aa versus 407 aa). Differs from Rv0867c by 1aa E235D in BCG Pasteur and BCG Tokyo.
YP_002643950.1	together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z
YP_002643951.1	Differs from Mb0894c by 1aa G29S
YP_002643953.1	In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 9 bp in-frame insertion (compared to Mycobacterium tuberculosis strain H37Rv), leads to a lightly longer product (609 aa versus 606 aa). In Mycobacterium bovis, an additional 3 bp in-frame deletion (compared to Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur and BCG Tokyo) leads to a product of 608 aa
YP_002643957.1	Differs from Mb0900c by 1aa D26G in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643959.1	In Mycobacterium bovis, Mycobaterium bovis BCG Pasteur, and BCG Tokyo, a single base deletion (A-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (438 aa versus 443 aa). Differs from Rv0878c and Mb0902c by 1aa K436Q in BCG Pasteur and BCG Tokyo
YP_002643961.1	possibly MarR-family
YP_002643965.1	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate
YP_002643970.1	forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle
YP_002643971.1	Differs from Rv0890c by 1aa A866P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably LuxR-family
YP_002643972.1	Differs from Rv0891c by 1aa G37V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643975.1	possibly LuxR-family
YP_002643977.1	type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH
YP_002643986.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002643988.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-G) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Rv0907 by 1aa, L322P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643990.1	Differs from Rv0909 by 1aa, Q45H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643994.1	Differs from Mb0937c by 1aa P233L in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002643995.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_002643999.1	Differs from Rv0918 by 1aa, G46S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644001.1	Differs from Rv0920c by 1aa, E249D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644005.1	In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, Rv0924c and Rv0925c exist as 2 genes. In Mycobacterium bovis, a single base deletion (T-*) leads to a single product, Mb0948c. Differs from Rv0924c by 1aa, A216P in BCG Pasteur and BCG Tokyo
YP_002644006.1	In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, Rv0924c and Rv0925c exist as 2 genes. In Mycobacterium bovis, a single base deletion (t-*) leads to a single product, Mb0948c; Nramp; Mramp
YP_002644011.1	Differs from Rv0930 by 1aa, T5M in Mycobacterium CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644012.1	In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-T) splits pknD into 2 parts,pknDa and pknDb
YP_002644013.1	In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-T) splits pknD into 2 parts,pknDa and pknDb
YP_002644014.1	Differs from Rv0932c by 1aa, A115S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644015.1	In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-T, position 1041448-1041449) splits pstB into 2 parts, pstBa and pstBb
YP_002644016.1	In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-T, position 1041448-1041449) splits pstB into 2 parts, pstBa and pstBb
YP_002644017.1	Differs from Rv0934 by 1aa, A352V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644021.1	catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA and has been shown to have polymerase activity
YP_002644022.1	cyclase/dehydrase
YP_002644028.1	Differs from Rv0945 by 1aa, G180R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644029.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_002644034.1	catalyzes the interconversion of succinyl-CoA and succinate
YP_002644035.1	Catalyzes the only substrate-level phosphorylation in the TCA cycle
YP_002644036.1	Differs from Rv0953c and Mb0978c by 1aa, A50T in Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002644039.1	glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate
YP_002644040.1	involved in de novo purine biosynthesis
YP_002644041.1	Differs from Rv0958 by 1aa, P274S in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644046.1	Differs from Rv0962c by 1aa, L186P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644047.1	Differs from Rv0963c and Mb0988c by 1aa, S258G in BCG Pasteur and BCG Tokyo
YP_002644048.1	Differs from Rv0964c by 1aa, T124P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644049.1	Differs from Rv0965c by 1aa, H94R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644050.1	Differs from Rv0966c by 2aa, A175V, G186W in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644053.1	Differs from Rv0969 by 1aa, N484D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644055.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002644056.1	Differs from Rv0972c by 1aa, H236Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644057.1	Differs from Rv0973c by 1aa, F220I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644058.1	Differs from Rv0974c by 1aa, K51N in Mycobacteium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo
YP_002644059.1	In Mycobacterium bovis, a frameshift due to a single base deletion (T-*) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG pasteur, and BCG Tokyo
YP_002644063.1	In Mycobacterium bovis, Mycobacterim bovis BCG Pasteur, and BCG Tokyo, a 115 bp to 127 bp substitution leads to as lightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (335 aa versus 331aa)
YP_002644065.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_002644066.1	Differs from Rv0980c by 1aa, Q43H, and from Mb1006c by 1aa, A270T in Mycobacteium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo
YP_002644067.1	Differs from Rv0981 by 1aa, S70G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo
YP_002644068.1	Differs from Rv0982 by 1aa, H339L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo
YP_002644069.1	Differs from Rv0983 by 1aa, P390L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo
YP_002644071.1	forms homopentamer; channel that opens in response to pressure or hypoosmotic shock
YP_002644072.1	Differs from Rv0986 by 1aa, L228V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo
YP_002644073.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, Rv0987 exists as a single gene. In Mycobacterium bovis, a single base transition (G-A) introduces a stop codon that splits Rv0987 in two parts, Mb1013 and Mb1014. Differs from Rv0987 by 1aa, V717F in BCG Pasteur and BCG Tokyo
YP_002644074.1	Differs from Rv0988 by 2aa, I57V, D135Y in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.
YP_002644075.1	Differs from Rv0989c by 1aa, V321I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo
YP_002644076.1	Differs from Rv0990c by 1aa, A54S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.
YP_002644078.1	Differs from Rv0992c by 2aa, I3M, S135G, and from Mb1019c by 1aa, S135G in BCG Pasteur and BCG Tokyo
YP_002644079.1	Differs from Rv0993 by 1aa, R235Q in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002644080.1	Differs from Rv0994 by 1aa, G230C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.
YP_002644082.1	Differs from Rv0996 by 1aa, D92G, and from Mb1023 by 1aa, D92G in BCG Pasteur, and BCG Tokyo
YP_002644089.1	catalyzes the degradation of arginine to citruline and ammonia
YP_002644090.1	Differs from Rv1002c by 1aa, L115V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.
YP_002644093.1	catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine
YP_002644094.1	Differs from Rv1006 by 1aa, S535P, and from Mb1033 by 1aa, N25S in BCG Pasteur and BCG Tokyo
YP_002644095.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_002644096.1	Differs from Rv1008 by 1aa, N186T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; YjjV protein
YP_002644097.1	Differs from Rv1009 by 2aa, E282G, V357A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644098.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_002644099.1	catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis
YP_002644100.1	In Mycobacterium tuberculosis strain H37Rv, Rv1012 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-G) leads to a different NH2 terminus. Differs from Rv1012 by 1aa, N65S
YP_002644101.1	activates fatty acids by binding to coenzyme A
YP_002644102.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_002644103.1	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response
YP_002644104.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a 5 bp deletion (CACGC-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_002644105.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_002644106.1	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_002644107.1	probably TetR-family
YP_002644109.1	functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era
YP_002644110.1	Differs from Rv1022 by 1aa, P33T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644111.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_002644116.1	Differs from Rv1028c by 3aa, S83P, D295G, S368P, and from Mb1056c by 1aa, S83P in BCG Pasteur and BCG Tokyo
YP_002644118.1	catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_002644119.1	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_002644120.1	one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex
YP_002644126.1	Differs from Rv1037c by 1aa, L20Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644128.1	Differs from Rv1039c and Mb1068c by 1aa, K175N in BCG Pasteur and BCG Tokyo
YP_002644130.1	Differs from Rv1042c by 1aa, E129G in Mycobacterium bovis and BCG Pasteur. Differs from Mb1070c by G129E in Mycobacterium tuberculosis and Mycobacterium bovis BCG Tokyo
YP_002644131.1	Differs from Rv1043c by 1aa, T99A, and from Mb1072c by 1aa, G263C in BCG Pasteur and BCG Tokyo
YP_002644133.1	Differs from Mb1074 by 1aa, W104G in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002644134.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 1bp insertion, compared to Mycobacterium tuberculosis strains H37Rv, leads to different C-terminus
YP_002644136.1	Differs from Rv1048c and Mb1077c by 2aa, A37D, T173A in BCG Pasteur and BCG Tokyo.
YP_002644146.1	activates fatty acids by binding to coenzyme A
YP_002644155.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, 2 deletions each of 3 bp (CCG-* and CGC-*) and a 18 bp insertion leads to a longer product compared to their homolog in Mycobacterium tuberculosis strain H37Rv (671 aa versus 667 aa)
YP_002644156.1	In Mycobacterium bovis, insertions of 717 bp and 192 bp, and a 9 bp (TCCGCTGCC-*) deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (763 aa versus 463 aa). In Mycobacterium bovis BCG Pasteur a deletion of 99 bp leads to a smaller product compared to the homolog in Mycobacterium bovis (730 aa versus 763 aa). Mycobacterium bovis BCG Tokyo a deletion of 323 bp from BCG Pasteur leads to two products (204 aa, 401 aa)
YP_002644157.1	In Mycobacterium bovis, insertions of 717 bp and 192 bp, and a 9 bp (tccgctgcc-*) deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (763 aa versus 463 aa). In Mycobacterium bovis BCG Pasteur a deletion of 99 bp leads to a smaller product compared to the homolog in Mycobacterium bovis (730 aa versus 763 aa). Mycobacterium bovis BCG Tokyo a deletion of 323 bp from BCG Pasteur leads to two products (204 aa, 401 aa)
YP_002644158.1	Differs from Rv1069c and from Mb1098c by 1aa L481P in BCG Pasteur and BCG Tokyo.
YP_002644159.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002644160.1	catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA
YP_002644163.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_002644167.1	Differs from Rv1078 by 1aa T171I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644168.1	catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine
YP_002644169.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_002644176.1	In Mycobacterium bovis BCG Pasteur and Tokyo, insertions of 144 bp and 3 bp, and deletion of 42 bp, lead to a longer product compared to the homolog in Mycobacterium bovis (809 aa versus 774 aa). In Mycobacterium bovis, insertions of 3 bp (*-GCG) and 45 bp, and deletions of 18 bp and 9 bp (GGTGGGGCC-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (774 aa versus 767 aa)
YP_002644179.1	Differs from Rv1089 and Mb1118 by 1 aa N84T in BCG Pasteur and BCG Tokyo
YP_002644182.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 9 bp deletion (CCGGCGGCA-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (850 aa versus 853 aa)
YP_002644183.1	catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis
YP_002644184.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_002644187.1	Differs from Rv1096 by 1aa, S272P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644188.1	Differs from Rv1097c by 1aa, L23P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644189.1	class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_002644190.1	type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese
YP_002644191.1	Differs from Rv1100 and Mb1130 by 1aa, P21T in BCG Pasteur and BCG Tokyo
YP_002644192.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (T-*) leads to a shorter product with a different amino part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Mb1131c by 1 aa, E315D in BCG Pasteur and BCG Tokyo
YP_002644193.1	Differs from Rv1102c by 1aa, I65T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644198.1	catalyzes the bidirectional exonucleolytic cleavage of DNA
YP_002644199.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_002644200.1	Differs from Rv1109c and Mb1139c by 1aa, T147A in BCG Pasteur and BCG Tokyo
YP_002644201.1	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_002644203.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_002644206.1	Differs from Rv1115 by 1aa, P19S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644212.1	Differs from Mb1151c by 1aa, G53A in BCG Pasteur and BCG Tokyo
YP_002644213.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_002644214.1	similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate
YP_002644215.1	non-haem peroxidase
YP_002644217.1	Differs from Rv1125 by 1aa, G101S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644219.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_002644220.1	Differs from Rv1128c by 1aa, G270E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644222.1	Differs from Rv1130 by 2aa, G3D, L10F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644223.1	catalyzes the formation of citrate from acetyl-CoA and oxaloacetate
YP_002644224.1	Differs from Mb1163 by 1aa, T176M in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644225.1	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine
YP_002644234.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002644235.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002644238.1	In Mycobacterium tuberculosis strain H37Rv, Rv1145 and Rv1146 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-A) at H37Rv position 1273250-1273251 leads to a single product
YP_002644240.1	Differs from Rv1148c and Mb1179c by 1aa, N354H in BCG Pasteur and BCG Tokyo
YP_002644242.1	Modulates the activities of several enzymes which are inactive in their acetylated form
YP_002644244.1	Differs from Rv1153c by 2aa, T36A, G53D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002644245.1	Differs from Rv1154c by 1aa, A123T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644246.1	Differs from Rv1155 by 1aa, P115S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644248.1	Is 24 codons shorter than Rv1157c and Mb1188c due to 72bp deletion at position equivalent to H37Rv, 1283458-1283529. After codon 214
YP_002644250.1	involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis
YP_002644251.1	4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction
YP_002644253.1	Differs from Rv1161 by 2aa, L458V, G821D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644255.1	Differs from Rv1163 and Mb1195 by 1aa, L106P in Mycobacterium bovis BCG Pasteur.
YP_002644256.1	Differs from Rv1164 by 1aa, V200A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644257.1	Differs from Rv1165, Mb1197 by 1aa L98V in Mycobacterium bovis BCG Tokyo.
YP_002644260.1	In Mycobacterium tuberculosis strain H37Rv, PPE17 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-C) splits PPE17 into 2 parts, PPE17a and PPE17b
YP_002644264.1	Differs from Rv1172c by 1aa, H133Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644265.1	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis
YP_002644267.1	Differs from Rv1175c by 3aa, N90T, S210T, S649I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644270.1	catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis
YP_002644272.1	In Mycobacterium tuberculosis strain H37Rv, Rv1180 and Rv1181 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transversion (A-C) leads to a single product (similar to other organisms). Differs from Rv1181 by 2aa, A1068D, P1423A in BCG Pasteur and BCG Tokyo
YP_002644276.1	activates fatty acids by binding to coenzyme A
YP_002644277.1	Differs from Rv1186c by 1aa, A207P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644280.1	member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription
YP_002644284.1	activates fatty acids by binding to coenzyme A
YP_002644287.1	In Mycobacterium bovis, a 14 bp to 11 bp substitution leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (390 aa versus 391 aa). Differs extensively from orthologs Mb1228 and Rv1196 due to numerous substitutions and transitions. Region from aa 210 - 260 shows most difference
YP_002644288.1	Differs from Mb1229 by 1aa, A58T in BCG Pasteur and BCG Tokyo
YP_002644289.1	Differs from Rv1198 by 1aa, D12A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002644290.1	Differs from Rv1199c and Mb1231c by 1aa, G90D in Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002644293.1	catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate
YP_002644297.1	activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization
YP_002644303.1	Differs from Rv1212c by 2aa, I105V, W340L and from Mb1244c by 1aa, W340L in BCG Pasteur and BCG Tokyo
YP_002644304.1	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate
YP_002644305.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, PE14 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 5 bp deletion (cttgt-*) leads to a diffferent COOH terminus
YP_002644306.1	Differs from Rv1215c by 1aa, S169A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644308.1	Differs from Mb1249c by 1aa, A143T in BCG Pasteur and BCG Tokyo
YP_002644309.1	Differs from Rv1218c by 1aa, R243Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644310.1	Differs from Rv1219c and Mb1251c by 1aa, C113W in BCG Pasteur and BCG Tokyo
YP_002644312.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence
YP_002644314.1	Differs from Rv1223 by 2aa, L288F, N445S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644315.1	mediates the export of protein precursors bearing twin-arginine signal peptides
YP_002644317.1	Differs from Rv1226c by 1aa, A450V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644321.1	Differs from Rv1230c by 2aa, G45S, P97S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644323.1	Differs from Rv1232c by 1aa, G149C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644324.1	Differs from Rv1233c by 1aa, D46N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644330.1	Differs from Rv1239c by 1aa, E139K, and from Mb1271c by 1aa, H195R in BCG Pasteur and BCG Tokyo
YP_002644331.1	catalyzes the oxidation of malate to oxaloacetate
YP_002644335.1	Differs from Rv1244 by 1aa, K242Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644339.1	kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth
YP_002644340.1	Differs from Rv1249c by 1aa, T95A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644341.1	Differs from Rv1250 by 1aa, G278R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644344.1	Differs from Rv1253 by 1aa, V143M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644346.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 3007 bp deletion (RD13) leads to the fusion of Rv1257c and Rv1255c, and the deletion of Rv1256c, compared to Mycobacterium tuberculosis strain H37Rv
YP_002644349.1	In Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv1260 into 2 parts
YP_002644350.1	In Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv1260 into 2 parts
YP_002644352.1	Differs from Rv1262c by 1aa, R104P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644353.1	catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia
YP_002644354.1	Differs from Rv1264 by 1aa, C204R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644356.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, the pknH gene contains several substitutions, transitions and transversions compared to Mycobacterium tuberculosis strain H37Rv. The most significant difference results from a 127 bp to 24 bp substitution that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (596 aa versus 626 aa). Differs from Mb1297c by 2aa, F374L, I396N in BCG Pasteur and BCG Tokyo
YP_002644360.1	Differs from Mb1301c by 1aa, A134T in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644364.1	Differs from Rv1274 by 1aa, P168L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644366.1	Differs from Rv1276c by 1aa, S92T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644375.1	with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP
YP_002644376.1	in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis
YP_002644378.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 153 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (405 aa versus 456 aa)
YP_002644383.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_002644385.1	catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine
YP_002644386.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_002644387.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate
YP_002644388.1	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_002644389.1	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_002644390.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_002644391.1	Differs from Mb1332 by 1aa, G121A, and from Rv1300by 2aa, G121A, C194R in Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002644392.1	Differs from Rv1301 by 1aa, Q196P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002644393.1	Differs from Rv1302 by 1aa, G357V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644395.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_002644396.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0
YP_002644397.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_002644398.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_002644399.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_002644400.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_002644401.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_002644402.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_002644403.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 2 bp deletion (CG-*) at the 3' end leads to a slightly shorter product compared to Mycobacterium tuberculosis strain H37Rv (144 aa versus 147 aa). Also differs from Rv1312 by 1aa, V3A in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002644404.1	Equivalent to Rv1313c (IS1557) in BCG Tokyo. Equivalent to Mb1345c and Mb1346c in BCG Pasteur (BCG_1373c and BCG_1374c). In Mycobacterium tuberculosis strain H37Rv, Rv1313c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a 12 bp to 1bp substitution (CTTGTCGTGGCC-T) splits Rv1313c into 2 parts
YP_002644406.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_002644408.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, alkA exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a premature stop codon that splits alkA into 2 parts, alkAa and alkAb
YP_002644411.1	Differs from Rv1320c by 1aa, A531T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644412.1	Differs from Rv1321 by 1aa, R144S in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644415.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis
YP_002644417.1	Differs from Rv1325c by 3aa:AGG, there are deleted in Mycobacterium bovis BCG Tokyo.
YP_002644418.1	catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain
YP_002644420.1	Differs from Rv1328 by 3aa, G532D, F576V, S801A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644422.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate
YP_002644423.1	involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA
YP_002644430.1	converts L-glutamate to D-glutamate, a component of peptidoglycan
YP_002644432.1	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_002644433.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_002644435.1	Differs from Rv1343c by 1aa, A81E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644436.1	carries the fatty acid chain in fatty acid biosynthesis
YP_002644437.1	converts medium- to long-chain aliphatic fatty acids into acyl adenylate; involved in mycobactin synthesis
YP_002644442.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_002644447.1	Differs from Rv1355c by 1aa (P81L) in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644449.1	Differs from Rv1357c and Mb1392c by 1aa, S276T in BCG Pasteur and BCG Tokyo
YP_002644450.1	Differs from Rv1358 by 1aa A442D, and from Mb1393 by 1aa, G31V in BCG Pasteur and BCG Tokyo
YP_002644451.1	Differs from Mb1394 by 1aa, G187R in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644453.1	Differs from Rv1361c by 3aa, Q30K, V55T, P325Q in BCG Pasteur and BCG Tokyo, and more extensively from Mb1396c due to several substitutions, transitions and transversions between codons 158-260
YP_002644454.1	Differs from Rv1362c by 1aa, G103V Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644455.1	Difefrs from Mb1398c by 1aa, T155N in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644456.1	Differs from Rv1364c by 2aa, T236A, E465A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644457.1	Differs from Rv1365c by 1aa, K82E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644459.1	Differs from Rv1367c by 1aa, V169I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644461.1	In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-A) splits Rv1371 into 2 parts, with the latter being the more likely product
YP_002644462.1	In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-A) splits Rv1371 into 2 parts, with the latter being the more likely product. Differs from both Mb1405 and Rv1371 by 1aa, V210I in Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002644463.1	Differs from Rv1372 and Mb1406 by 2aa, N75K, A101T in Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002644464.1	In Mycobacterium tuberculosis strain H37Rv, Rv1373 exists as a single gene as is the case in Mycobacterium bovis BCG Pasteur. In Mycobacterium bovis, a frameshift due to a single base insertion (*-C) splits Rv1373 into 2 parts, Mb1407 and Mb1408. Differs from Rv1373 by 2aa, additional P, P155, and L232P in BCG Pasteur. In Mycobacterium bovis BCG Tokyo, a frameshift due to two base insertions (*-cc) splits Rv1373 into 2 parts (182 aa, 155 aa). 9Cs in BCG Tokyo, 10Cs in BCG Pasteur.
YP_002644465.1	In Mycobacterium tuberculosis strain H37Rv, Rv1373 exists as a single gene as is the case in Mycobacterium bovis BCG Pasteur. In Mycobacterium bovis, a frameshift due to a single base insertion (*-) splits Rv1373 into 2 parts, Mb1407 and Mb1408. Differs from Rv1373 by 2aa, additional P, P155, and L232P in BCG Pasteur. In Mycobacterium bovis BCG Tokyo, a frameshift due to two base insertions (*-CC) splits Rv1373 into 2 parts (182 aa, 155 aa).
YP_002644466.1	Differs from Rv1374c by 1aa, A136T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644467.1	Differs from Rv1375 by 1aa, R86G, and from Mb1410by 1aa, R322P in Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002644468.1	Differs from Rv1376 by 1aa, P236R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644470.1	Differs from Rv1378c by 1aa, W37R, and from Mb1413c by 1aa, R9H in BCG Pasteur and BCG Tokyo
YP_002644471.1	regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity
YP_002644472.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_002644473.1	catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis
YP_002644475.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_002644476.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_002644477.1	type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase
YP_002644479.1	Differs from Rv1387 by 1aa, A94V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644481.1	Essential for recycling GMP and indirectly, cGMP
YP_002644482.1	Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_002644483.1	catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine
YP_002644484.1	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_002644486.1	Differs from Rv1394c by 1aa, L135R in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644488.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 372 bp deletion leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (452 aa versus 576 aa). Differs from Rv1396c by 2 aa, S66R, H300R in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002644489.1	Differs from Rv1397c by 1aa, G103D in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002644491.1	Differs from Rv1399c and Mb1434c by 1aa, A46P in BCG Pasteur and BCG Tokyo
YP_002644494.1	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_002644498.1	modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth
YP_002644499.1	Differs from Rv1407 by 1aa, L427I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644500.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_002644501.1	Differs from Rv1409 by 2aa, N30K, T71A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; diaminohydroxyphosphoribosylaminopyrimidine deaminase, 5-amino-6-(5-phosphoribosylamino) uracil reductase
YP_002644502.1	P55
YP_002644504.1	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine
YP_002644507.1	bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate
YP_002644508.1	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not
YP_002644512.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_002644514.1	Differs from Mb1457 by 1aa, A86V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644517.1	Differs from Rv1425 by 1aa, L343P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644519.1	activates fatty acids by binding to coenzyme A
YP_002644523.1	Differs from Rv1431 by 2aa, T65N, Q455K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644525.1	Differs from Rv1433 and Mb1468 at C-terminal end due to 1bp deletion at position equivalent to H37Rv 1612222-1612222 in Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002644527.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, an in-frame insertion of 21 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (209 aa versus 202 aa). Differs from Rv1435c by 1aa, T67A in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002644529.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_002644530.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_002644533.1	Differs from Rv1441c by 1aa G236D and from Mb1476c by 1aa T354N in BCG Pasteur and BCG Tokyo
YP_002644538.1	Differs from Rv1446v by 1aa P192R in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002644539.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_002644540.1	catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate
YP_002644541.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_002644542.1	In Mycobacterium bovis, insertions of 27 bp, 207 bpand 27 bp, substitutions of 60 bp to 63 bp and 11 bp, and a 27 bp deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (1408 aa versus 1329 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, one 27bp-insertion is missing, leading to a product of 1399 aa
YP_002644543.1	converts protoheme IX and farnesyl diphosphate to heme O
YP_002644544.1	In Mycobacterium bovis BCG Pasteur and Tokyo, a insertion of 51 bp, several substitutions and a deletion of 207 bp, lead to a smaller product compared to its homolog Mycobacterium bovis (740 aa versus 795 aa). Differs from BCG_1513c by 5aa, G647D, G648I, D649I, G650V, T651A in BCG Tokyo.
YP_002644545.1	Differs from Rv1453 by 1aa Q405P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644551.1	Differs from Rv1459c by 1aa, E113K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644552.1	Differs from Rv1460 by 2aa, F198I, V265 and from Mb1495 by 1aa, F198I in BCG Paasteur and BCG Tokyo
YP_002644554.1	Differs from Rv1462 by 1aa, D183N in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644564.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002644566.1	Differs from Rv1473A by 1aa, P60S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644568.1	Catalyzes the conversion of citrate to isocitrate
YP_002644574.1	Differs from Rv1481 and Mb1517 by 1aa, D254N in BCG Pasteur and BCG Tokyo
YP_002644577.1	Catalyzes a key regulatory step in fatty acid biosynthesis
YP_002644578.1	protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic
YP_002644579.1	First 270 aa identical to Mb1522c and Rv1486c (but differs by 1aa, N198K), then frameshifts due to extra base, g, at position equivalent to Mycobacterium tuberculosis strain H37Rv position 1676073-1676074. 2GC in BCG Tokyo, 1GC in BCG Pasteur.
YP_002644587.1	MDM; functions in conversion of succinate to propionate
YP_002644588.1	Differs from Rv1494 and Mb1531 by 1aa, L12S in BCG Pasteur and BCG Tokyo
YP_002644590.1	functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins
YP_002644592.1	Differs from Rv1498c by 1aa, H191R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644593.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (a-g) at the 5' start leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (63 aa versus 70 aa)
YP_002644595.1	Differs from Rv1500 and Mb1538 by 1aa, E45D in BCG Pasteur and BCG Tokyo
YP_002644597.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, Rv1502 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (T-*), splits Rv1502 into 2 parts, Mb1540 and Mb1541. Differs from Rv1502 by 1aa, C213Y in BCG Pasteur and BCG Tokyo
YP_002644598.1	catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis
YP_002644599.1	In Mycobacterium tuberculosis strain H37Rv, Rv1503c and Rv1504c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transversion (T-G) leads to a single product. Differs from Rv1503c by 1aa, K316E in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002644600.1	Differs from Rv1517 by 1aa, F188L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644601.1	Differs from Rv1518 by 2aa, R266S, L317M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644604.1	activates fatty acids by binding to coenzyme A
YP_002644605.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transversion (C-A) creating a stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1107 aa versus 1146 aa). Differs from Rv1522c (1146 aa) by 1aa, P381S, and from Mb1549c, (1107 aa) by 2aa, T204A, S947N in BCG Pasteur and BCG Tokyo
YP_002644610.1	Differs from Rv1527c by 2aa, T532P, L1439F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644612.1	activates fatty acids by binding to coenzyme A
YP_002644613.1	Differs from Rv1530 and Mb1557 by 1aa, L330P in BCG Pasteur and BCG Tokyo
YP_002644619.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin)
YP_002644620.1	involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
YP_002644622.1	lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_002644627.1	In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, Rv1544 and Mb1571 exist as a single gene. In BCG Tokyo exists same as Rv1544 and Mb1571. In Mycobacterium bovis BCG Pasteur, two genes exist as a result of a 10 bp deletion that has occurred at a position equivalent to H37Rv position 1746147-1746156I
YP_002644630.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
YP_002644631.1	Differs from Rv1548c by 1aa, G258D, and from Mb1575c by 1aa, V68A in BCG Pasteur and BCG Tokyo
YP_002644632.1	In Mycobacterium tuberculosis strain H37Rv, Rv1549 and Rv1550 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, two single base insertions (*-C and *-C) lead to a single product. Differs from Rv1550 by 1aa, S362L in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002644633.1	PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA
YP_002644634.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_002644635.1	In Mycobacterium tuberculosis strain H37Rv, Rv1553 and Rv1554 exist as 2 genes. In Mycobacterium bovis (Mb1579), a 4bp insertion (*-GGGG) leads to a single product and in Mycobacterium bovis BCG Pasteur a 10 bp insertion at position equivalent to H37Rv 1760171-1760172 leads to insertion of two additional Gly codons. In Mycobacterium bovis BCG Tokyo, a 9 bp insertion at position equivalent to H37Rv 1760171-1760172 leads to insertion of three additional Gly codons. 16Gs in BCG Tokyo, 17Gs in BCG Pasteur.; iron-sulfur subunit frdB
YP_002644636.1	In Mycobacterium tuberculosis strain H37Rv, Rv1553 and Rv1554 exist as 2 genes. In Mycobacterium bovis, a 4bp insertion (*-GGGG) leads to a single product and in Mycobacterium bovis BCG Pasteur a 10 bp insertion at position equivalent to H37Rv 1760171-1760172 leads to insertion of two additional Gly codons. In Mycobacterium bovis BCG Tokyo, a 9 bp insertion at position equivalent to H37Rv 1760171-1760172 leads to insertion of three additional Gly codons.; membrane anchor subunit
YP_002644637.1	in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane
YP_002644639.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 2153 bp insertion leads to a new protein with no equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to the TbD1 region
YP_002644640.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 2153 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Belongs to the TbD1 region
YP_002644642.1	catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic
YP_002644645.1	In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, treZa and treZb exist as a single gene, treZ. In Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base deletion at position equivalent to H37Rv 1766233-1766233 leads to frameshift and two genes, treZa and treZb
YP_002644646.1	In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, treZa and treZb exist as a single gene, treZ. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, a single base deletion at position equivalent to H37Rv 1766233-1766233 leads to frameshift and two genes, treZa and treZb
YP_002644647.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and in Mycobacterium tuberculosis strain H37Rv, treY exists as a single gene. In Mycobacterium bovis, a large deletion of 806 bp, RD17, splits Rv1563c into two parts, treYa and treYb
YP_002644652.1	catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate
YP_002644653.1	catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine
YP_002644654.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_002644656.1	In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis, Rv1587c possibly exists as a pseudogene that has been disrupted when the phage entered. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, the prophage is absent and the C-terminal part of protein differs accordingly
YP_002644657.1	Differs from Rv1588c by 3aa, T63A, L91R, I131V
YP_002644658.1	catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine
YP_002644661.1	Differs from Rv1592c by 1aa, V322I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644663.1	3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate
YP_002644664.1	catalyzes the formation of oxaloacetate from L-aspartate
YP_002644665.1	catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide
YP_002644666.1	Differs from Rv1597 by 2aa, D21G, M93L, and from Mb1623 by 1aa, M93L in BCG Pasteur and BCG Tokyo
YP_002644668.1	catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_002644669.1	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis
YP_002644670.1	catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis
YP_002644671.1	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_002644672.1	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis
YP_002644673.1	Differs from Rv1604 by 3aa, H93Y, Q124P, L251P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644674.1	catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_002644675.1	PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers
YP_002644678.1	with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine
YP_002644680.1	involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water
YP_002644681.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_002644682.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_002644683.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_002644686.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_002644687.1	Differs from Rv1618 by 1aa, L121H in Mycobacterium tuberculosis CDC1331, Mycobacteoium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644689.1	'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein
YP_002644690.1	'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein
YP_002644693.1	Differs from Rv1624c by 1aa, A178T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644697.1	Differs from Rv1628c and Mb1654c by 1aa, V93A in BCG Pasteur and BCG Tokyo
YP_002644698.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_002644699.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_002644700.1	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain
YP_002644702.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_002644703.1	Differs from Rv1634 by 2aa, Q13E, R198G, and from Mb1660 by 1aa, Q13E in BCG Pasteur and BCG Tokyo
YP_002644707.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_002644710.1	catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002644711.1	IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits
YP_002644713.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_002644714.1	Differs from Rv1644 by 1aa, P232L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644717.1	Differs from Rv1647 by 1aa, P2A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002644719.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_002644720.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_002644721.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, an in-frame insertion of 21 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1018 aa versus 1011 aa). Differs from Rv1651c by insertion of 7aa at position 152 and by 1aa, V179A in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002644722.1	catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate
YP_002644723.1	bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate
YP_002644724.1	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate
YP_002644725.1	catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine
YP_002644726.1	catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation
YP_002644727.1	regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes
YP_002644728.1	catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming
YP_002644729.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_002644731.1	Differs from Rv1661 by 2aa, W670R, P1176S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644732.1	Differs from Rv1662 by 6aa, Y78D, deletion of V692, V807A, G1260R, T1356A, C1468Y, and from Mb1690 by 1aa, deletion of V692 in BCG Pasteur and BCG Tokyo
YP_002644734.1	Differs from Rv1664 by 2aa, T36A, P350A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644737.1	In Mycobacterium tuberculosis strain H37Rv, Rv1668c and Rv1667c exist as 2 genes with a small overlap between them. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 10 bp insertion (*-TCTTGCCGCG) leads to a single product
YP_002644744.1	Differs from Rv1675c by 1aa, A59V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644749.1	Differs from Mb1707 by 1aa, A230G in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644752.1	activates fatty acids by binding to coenzyme A
YP_002644755.1	Differs from Rv1686c by 1aa, F20V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644757.1	responsible for recognizing base lesions in the genome and initiating base excision DNA repair
YP_002644758.1	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr)
YP_002644759.1	In Mycobacterium bovis, a 2 bp insertion (*-AC) at the 5' end, leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG Pasteur and BCG Tokyo (139 aa versus 127 aa)
YP_002644764.1	catalyzes the phosphorylation of NAD to NADP
YP_002644768.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_002644769.1	Differs from Mb1726 by 2aa, F43L, A202T in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644770.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_002644772.1	Differs from Rv1703c and Mb1729c by 1aa, S48G in BCG Pasteur and BCG Tokyo
YP_002644773.1	Differs from Rv1704c by 2aa, L93R, S122G, and from Mb1730c by 1aa, S122G in BCG Pasteur and BCG Tokyo
YP_002644774.1	Differs from Rv1705c by 2aa, A2D, V313L, and from Mb1731c by 1aa, A2D in BCG Pasteur. Differs from Rv1705c by 1aa, V313L in BCG Tokyo.
YP_002644777.1	Differs from Rv1707 by 1aa, Q438R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644778.1	Differs from Rv1708 by 1a, a T56A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644782.1	Catalyzes the formation of (d)CDP from ATP and (d)CMP
YP_002644783.1	synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_002644785.1	In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, Rv1715/fadB3 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) splits fadB3 into 2 parts, fadB3a and fadB3b
YP_002644786.1	Differs from Rv1716 by 2aa, G178S, A276V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002644788.1	In Mycobacterium tuberculosis strain H37Rv, exists as a single gene. In Mycobacterium bovis AF2122/97, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base deletion (C-*) leads to a shorter product with a different COOH terminus
YP_002644792.1	an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_002644796.1	Differs from Rv1726 by 1aa, Y326H, and from Mb1755 by 1aa, A61P in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002644797.1	Differs from Rv1727 and Mb1756 by 1aa, D22E in BCG Pasteur and BCG Tokyo
YP_002644801.1	NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate
YP_002644803.1	Differs from Rv1733c by 1aa, H68Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644804.1	Differs from Mb1763c by 1aa, T79A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644806.1	Diffesr from Rv1736c by 2aa, H53D, G77D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644809.1	Differs from Rv1739c by 1aa, L134R in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644811.1	Differs from Rv1741 by 1aa, T67K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644812.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-C) leads to shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_002644813.1	Differs from Mb1772 by 1aa, V56D in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo
YP_002644814.1	Differs from Rv1744c by 1aa, Q121R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644815.1	catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate
YP_002644816.1	Differs from Rv1746 by 1aa, T325A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644820.1	activates fatty acids by binding to coenzyme A
YP_002644821.1	Differs from Rv1751 by 2aa, T311M, L439V, and from Mb1780 by 1aa, T311M in BCG Pasteur and BCG Tokyo
YP_002644823.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, PPE24 differs in the 26 aa tandem repeat region, two copies less (in-frame deletion of 156 bp), and in the 25 aa repeat region, 2 and one more copies (in-frame insertion of 150bp and 75bp), respectively, compared to their homolog in Mycobacterium tuberculosis strain H37Rv
YP_002644824.1	Differs from Rv1754c and Mb1783c by 1aa, S546N in BCG Pasteur and BCG Tokyo
YP_002644825.1	Truncated by RvD2 deletion (6804bp) in Mycobacterium tuberculosis strain H37Rv
YP_002644826.1	No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to the RvD2 region
YP_002644827.1	No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to RvD2 region
YP_002644828.1	No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to RvD2 region
YP_002644829.1	Belongs to the RvD2 region. In Mycobacterium tuberculosis strain H37Rv, Rv1758 is interrupted by IS6110 insertion element and the 5'-end is deleted
YP_002644830.1	In Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as a single gene. In Mycobacterium bovis BCG Pasteur and Tokyo, and Mycobacterium bovis, a single base deletion (C-*) splits wag22 into 2 parts, wag22a and wag22b. Differs from Mb1789c and Rv1759c by three deletions R129 replaced by AG, 5aa deletion at position 739 and 12aa deletion at position 777 making protein smaller (802 aa versus 820 aa) in BCG Pasteur. 5aa deletion at position 739 and 12aa deletion at position 777 making protein smaller (803 aa versus 820 aa) in BCG Tokyo.
YP_002644831.1	In Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as a single gene. In Mycobacterium bovis BCG Pasteur and Tokyo, and Mycobacterium bovis, a single base deletion (C-*) splits wag22 into 2 parts, wag22a and wag22b. Differs from Mb1789c and Rv1759c by three deletions R129 replaced by AG, 5aa deletion at position 739 and 12aa deletion at position 777 making protein smaller (802 aa versus 820 aa) in BCG Pasteur. 5aa deletion at position 739 and 12aa deletion at position 777 making protein smaller (803 aa versus 820 aa) in BCG Tokyo.
YP_002644832.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Also differs from Rv1760 by 1aa, V219E
YP_002644835.1	In Mycobacterium tuberculosis strain H37Rv this region is occupied by IS6110 which interrupts the gene and appears to have deleted sequences downstream. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, there is an 848bp sequence that has replaced a 121bp sequence corresponding to H37Rv positions 1997332-1997452
YP_002644836.1	In Mycobacterium tuberculosis strain H37Rv this region is occupied by IS6110 which appears to have deleted sequences downstream. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, there is an 848bp sequence that has replaced a 121bp sequence corresponding to H37Rv positions 1997332-1997452
YP_002644837.1	In Mycobacterium bovis BCG Pasteur, deletion of 9068 bp (region of difference RD14), compared to Mycobacterium tuberculosis H37Rv (position: 1998226..2007293, 9068bp), Mycobacterium bovis AF2122/97 (position 1988666..1997751, 9086bp), and BCG Tokyo (position 1981204..1990289, 9086bp), removes genes Rv1765A-Rv1772 and merges truncated genes Rv1773c and Rv1765c in BCG Pasteur. Mycobacterium bovis (Mb1794c) and BCG Tokyo have a longer products to its homolg in Mycobacterium tuberculosis H37Rv (Rv1765c, 418 aa versus 365 aa).
YP_002644838.1	Equivqlent to Mycobacterium bovis (Mb1975c) and Mycobavterium tuberculosis H37Rv (Rv1765A) in Mycobacterium bovis BCG Tokyo
YP_002644839.1	Equivqlent to Mycobacterium bovis (Mb1975A) and Mycobavterium tuberculosis H37Rv (Rv1766) in Mycobacterium bovis BCG Tokyo
YP_002644840.1	Equivqlent to Mycobacterium bovis (Mb1796) and Mycobavterium tuberculosis H37Rv (Rv1767) in Mycobacterium bovis BCG Tokyo
YP_002644841.1	In Mycobacterium bovis and Mycobacterium BCG Tokyo, a 18bp insertion, leads to a longer product compared to its homolog in Mycobacterium tuberculosis H37Rv (624 aa versus 618 aa).
YP_002644842.1	Equivqlent to Mycobacterium bovis (Mb1798) and Mycobavterium tuberculosis H37Rv (Rv1769) in Mycobacterium bovis BCG Tokyo
YP_002644843.1	Equivqlent to Mycobacterium bovis (Mb1799) and Mycobavterium tuberculosis H37Rv (Rv1770) in Mycobacterium bovis BCG Tokyo
YP_002644844.1	Equivqlent to Mycobacterium bovis (Mb1800) and Mycobavterium tuberculosis H37Rv (Rv1771) in Mycobacterium bovis BCG Tokyo
YP_002644845.1	Equivqlent to Mycobacterium bovis (Mb1801) and Mycobavterium tuberculosis H37Rv (Rv1772) in Mycobacterium bovis BCG Tokyo
YP_002644846.1	Equivqlent to Mycobacterium bovis (Mb1802c) and Mycobavterium tuberculosis H37Rv (Rv1773c) in Mycobacterium bovis BCG Tokyo
YP_002644850.1	Differs from Rv1777 by 1aa Q325H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644851.1	Differs from Mb1807c by 1aa T32R in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644854.1	Differs from Rv1781c and Mb1810c by 1aa, T12A in BCG Pasteur and BCG Tokyo
YP_002644855.1	Differs from Rv1782 by 1aa H41R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644856.1	In Mycobacterium tuberculosis strain H37Rv, Rv1783 and Rv1784 exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base transversion (a-t) leads to a single product. Differs from Rv1783 and Mb1812 by 1aa, V692A in BCG Pasteur, identical to Rv1784 in BCG Pasteur and Tokyo.
YP_002644859.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 8 bp to 5 bp substitution (AGCCCGGT-CCGGG), leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (364 aa versus 365 aa). Identical to Mb1815
YP_002644861.1	Differs from Mb1817 by 1aa, S274A, identical to Rv1789 in BCG Pasteur and BCG Tokyo
YP_002644862.1	Identical to Rv1790 differs from Mb1818 by 1aa, P190S in BCG Pasteur and BCG Tokyo
YP_002644864.1	Differs from Rv1792 by 1aa Q48M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644867.1	Differs from Mb1823 and Rv1795 by 1aa, T256A and D261G, respectively, in BCG Pasteur and BCG Tokyo
YP_002644872.1	Differs from Rv1800 by 3aa, W144C, V253F, V432I, and from Mb1828 by 1aa, V432I in BCG Pasteur and BCG Tokyo
YP_002644875.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS32 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base transition (C-T) splits PE_PGRS32 into 2 parts, PE_PGRS32a and PE_PGRS32b
YP_002644876.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS32 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base transition (C-T) splits PE_PGRS32 into 2 parts, PE_PGRS32a and PE_PGRS32b
YP_002644880.1	Differs from Rv1807 by 2aa, S223F, L234V. Identicalto Mb1836 in BCG Pasteur and BCG Tokyo
YP_002644881.1	Differs from Rv1808 by 1aa, A301G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644882.1	In Mycobacterium tuberculosis strain H37Rv, PPE33 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base transition (C-T) splits PPE33 into 2 parts, PPE33a and PPE33b
YP_002644884.1	MgtC
YP_002644885.1	Differs from Rv1812c by 1aa, P30L in Mycobacteium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002644888.1	Differs from Rv1815 by 1aa, F83I in Mycobacteium tuberculosis CDC1551, Mycobacteium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002644892.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 9 bp insertion (*-GCCGCCGGC), leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (501 aa versus 498 aa). Differs from Rv1818c by 4aa, S233G, and deletion of 3aa near C-terminus. Identical to Mb1849c
YP_002644893.1	Differs from Rv1819c by 1aa, V603I in BCG Pasteur and BCG Tokyo
YP_002644895.1	SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins
YP_002644900.1	part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor
YP_002644903.1	Differs from Mb1860 by 1aa R93C in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002644906.1	acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine
YP_002644908.1	Differs from Mb1865 by 1aa, V272A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644910.1	Differs from Rv1836c by 2aa, C137R, H591R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644911.1	catalyzes the formation of malate from glyoxylate and acetyl-CoA
YP_002644914.1	In Mycobacterium bovis, an in-frame deletion of 147bp leads to a shorter protein compared to its homolog in Mycobacterium tuberculosis strain H37Rv (466 aa versus 518 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a deletion of 1bp, splits PPE34 into 2 parts, PPE34a and PPE34b
YP_002644915.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 12 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (349 aa versus 345 aa)
YP_002644916.1	Differs from Rv1842c by 1aa, S437L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644917.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_002644918.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_002644919.1	Differs from Rv1845c and Mb1876c by 1aa, A222V in BCG Pasteur and BCG Tokyo
YP_002644920.1	Differs from Rv1846c by 1aa, Y92D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644921.1	Differs from Rv1847 by 1aa, L90V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644922.1	UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter
YP_002644923.1	ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta)
YP_002644924.1	ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits
YP_002644925.1	Differs from Rv1851 by 1aa, L34V in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002644928.1	Differs from Rv1854c by 1aa, R313G, and Mb1885c by 2aa, R284W, R313G in BCG Pasteur and BCG Tokyo
YP_002644930.1	Differs from Rv1856c by 1aa, H185R in BCG Pasteur and BCG Tokyo
YP_002644933.1	Differs from Rv1859 by 1aa, M313T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644934.1	Differs from Rv1860 by 1aa, L136F in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644940.1	Differs from Rv1866 by 1aa, Q17E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644941.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_002644942.1	Differs from Rv1868 and Mb1899 by 1aa, G621D in BCG Pasteur and BCG Tokyo
YP_002644943.1	Differs from Mb1900c and Rv1869c by 1aa, P4S in BCG Pasteur and BCG Tokyo
YP_002644944.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transversion (T-A) and a single base transition (C-T) lead to a slightly longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (222 aa versus 211 aa)
YP_002644946.1	Differs from Rv1872c by 2aa, A59G, A176V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cytochrome
YP_002644947.1	Differs from Mb1904 by 1aa, D102N in BCG Pasteur and BCG Tokyo
YP_002644951.1	In Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-C), splits Rv1877 into 2 parts
YP_002644952.1	In Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-C), splits Rv1877 into 2 parts
YP_002644953.1	Identical to Rv1878, differs from Mb1910 by 1aa, A275T in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002644958.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 15 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (158 aa versus 153 aa)
YP_002644960.1	catalyzes the interconversion of chorismate to prephenate
YP_002644961.1	Differs from Rv1886c and Mb1918c by 1aa, L140F
YP_002644962.1	Differs from Rv1887 and Mb1919 by 1aa, C121Y in BCG Pasteur and BCG Tokyo
YP_002644963.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 10 bp insertion (*-TCCGATCACC) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv (239 aa versus 186 aa)
YP_002644971.1	In Mycobacterium tuberculosis strain H37Rv, Rv1895 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, two frameshifts due to a single base deletion (A-*) and a single base insertion (*-T), consecutively, splits Rv1895 into 2 main parts, Mb1928 and Mb1929
YP_002644972.1	In Mycobacterium tuberculosis strain H37Rv, Rv1895 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, two frameshifts due to a single base deletion (A-*) and a single base insertion (*-T), consecutively, splits Rv1895 into 2 main parts, Mb1928 and Mb1929
YP_002644974.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_002644976.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (358 aa versus 343 aa)
YP_002644977.1	Differs from Rv1900c and Mb1935c by 1aa, M204I and R170Q, respectively, in BCG Pasteur and BCG Tokyo
YP_002644981.1	Differs from Rv1904 by 1aa, M130T in BCG Pasteur and BCG Tokyo
YP_002644982.1	Differs from Rv1905c by 1aa, T240P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644985.1	Differs from Rv1908c by 1aa, L463R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644986.1	Differs from Rv1909c and Mb1944c by 1aa, V46A in BCG Pasteur and BCG Tokyo
YP_002644989.1	Differs from Rv1912c by 1aa, G328D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644990.1	Differs from Rv1913 and Mb1948 by 1aa, C7R in BCG Pasteur and BCG Tokyo
YP_002644992.1	In Mycobacterium tuberculosis strain H37Rv, aceAa and aceAb exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base insertion (*-T) leads to a single product
YP_002644993.1	Equivalent to Mb1951c and Rv1917c but differs by several in-frame insertion and deletion events. Differs from Mb1951c by 69 bp insertion, 69 bp deletion and 225 bp deletion. Differs from Rv1917c by deletions of 12 and 138 bp, insertions of 552 and 150 bp, and substitution of 52bp by 628 bp in BCG Pasteur and BCG Tokyo
YP_002644994.1	In Mycobacterium tuberculosis strain H37Rv, PPE35 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-T) splits PPE35 into 2 parts, PPE35a and PPE35b. Differs from Mb1953c by 1aa, F565V in Mycobacterium bovis BCG Pasteur and BCG Tokyo.
YP_002644996.1	Differs from Rv1920 by 1aa, I130M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002644999.1	Differs from Rv1923 by 2aa, D73G, N181D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteyr, and BCG Tokyo
YP_002645001.1	activates fatty acids by binding to coenzyme A
YP_002645008.1	antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein
YP_002645011.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002645015.1	In Mycobacterium bovis, a single base deletion (T-*) leads to a longer product with a different COOH part compared to its homologs in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (244 aa versus 171 aa)
YP_002645016.1	GTP cyclohydrolase II
YP_002645020.1	Differs from Rv1944c and Mb1979c by 2aa, E4D, A5T, due to 2 bp substitution ta-cc in BCG Pasteur and BCG Tokyo
YP_002645021.1	Differs from Mb1980 and Rv1945 by substitutions of 44, 29, 2, 10 and 34 bp, or 44, 29, 4, 2, 10 and 34 bp, respectively. Corresponding to 10 aa from Rv1945, L242V, N264H, A267G, F268L, A271G, K285R, I291V, N328H, H417K and P426A, and to 9 aa from Mb1980, N264H, A267G, F268L, A271G, K285R, I291V, N328H, H417K and P426A in BCG Pasteur and BCG Tokyo
YP_002645022.1	Differs from Rv1946c by 1aa, T98A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645024.1	Differs from Rv1948c by 1aa, R5G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645025.1	Differs from Rv1949c by 1aa, L188F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645030.1	Differs from Rv1954c by 1aa, R150H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645041.1	In Mycobacterium bovis Mycobacterium bovis BCG Pasteur and BCG Tokyo, a large deletion of 12719 bp (RD7) leads to the loss of the COOH part of Rv1964|yrbE3A, the entire mce3 operon and the following genes up to Rv1978, compared to Mycobacterium tuberculosis strain H37Rv. Follow by a second deletion of 10287bp, RD2 region (only in Mycobacterium bovis BCG Pasteur), which removes genes Rv1979c-Rv1787 and merges truncated part of Rv1978 and Rv1988 compared to Mycobacterium tuberculosis strain H37Rv
YP_002645043.1	Differ from Rv1979c by 2aa, G286D, I457V in Mycobacterium bovis and Mycobacterium bovis BCG Tokyo.
YP_002645044.1	Equivalent to Mycobacterium bovis (Mb2002c) and Mycobacterium tuberculosis H37Rv (Rv1980c) in Mycobacterium bovis BCG Tokyo.; antigen MPT64/MPB64
YP_002645045.1	Differ from Rv1981c by 1aa, R5L in Mycobacterium bovis and Mycobacterium bovis BCG Tokyo.
YP_002645046.1	Equivalent to Mycobacterium bovis (Mb2004c) and Mycobacterium tuberculosis H37Rv (Rv1982c) in Mycobacterium bovis BCG Tokyo
YP_002645047.1	Differ from Rv1983 by 1aa, T220A in Mycobacterium bovis and Mycobacterium bovis BCG Tokyo.
YP_002645048.1	Equivalent to Mycobacterium bovis (Mb2006c) and Mycobacterium tuberculosis H37Rv (Rv1984c) in Mycobacterium bovis BCG Tokyo
YP_002645049.1	specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport
YP_002645050.1	Equivalent to Mycobacterium bovis (Mb2008) and Mycobacterium tuberculosis H37Rv (Rv1986) in Mycobacterium bovis BCG Tokyo
YP_002645051.1	Equivalent to Mycobacterium bovis (Mb2009) and Mycobacterium tuberculosis H37Rv (Rv1987) in Mycobacterium bovis BCG Tokyo
YP_002645052.1	Equivalent to Mycobacterium bovis (Mb2010) and Mycobacterium tuberculosis H37Rv (Rv1988)in Mycobacterium bovis BCG Tokyo
YP_002645062.1	Differs from Rv1997 and Mb2020 by 1aa, D138E in BCG Pasteur and BCG Tokyo
YP_002645063.1	Differs from Rv1998c by 1aa, R230S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645066.1	Differs from Rv2001 by 1aa, H113R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645071.1	Differs from Rv2006 and Mb2029 by 1aa, S80G and L1245P, respectively, in BCG Pasteur and BCG Tokyo
YP_002645078.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (c-t) at the 5' start, leads to a longer product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (206 aa versus 159 aa)
YP_002645079.1	Identical to Mb2037 including extra 5 aa at C-terminus compared to Rv2014 in Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002645080.1	Differs from Mb2038c by 1aa S59L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645082.1	Differs from Rv2017 by 1aa, E262A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645083.1	Differs from Rv2018 by 1aa, G116D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645089.1	Belongs to the RvD1 region. Absent in Mycobacterium tuberculosis strain H37Rv
YP_002645090.1	Belongs to the RvD1 region. Absent in Mycobacterium tuberculosis strain H37Rv. Differs from Mb2048c by 1aa, E139K in Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002645091.1	In Mycobacterium tuberculosis strain H37Rv, a large deletion region (RvD1) exists in between Rv2023 and Rv2024. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 5000 bp insertion at this region results in Mb2049c being a much larger product with a different COOH part (1606 aa versus 515 aa), and in 2 extra genes, Mb2046c and Mb2047c. Differs from N-terminal part of Rv2024c (truncated by RvD1) by 3aa, R47W, G154D, C289R and Mb2049c by 1aa, F341V in BCG Pasteur and BCG Tokyo
YP_002645094.1	Differs from Rv2027c by 1aa, V15L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645097.1	In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, Rv2030c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (G-*) splits Rv2030c into 2 parts, Mb2055c and Mb2056c
YP_002645099.1	Differs from Rv2032 by 1aa, L318P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645103.1	Differs from Rv2036 by 1aa, V93A due to 2bp substitution cc-tt in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645104.1	Differs from Rv2037c by 1aa, Y312C in Mycobacterium tuberclosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645106.1	Differs from Rv2039c by 1aa, F131V in Mycobacterium tuberclosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645110.1	Differs from Rv2043c by 1aa, D57H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645113.1	Differs from Rv2046 by 1aa, P17S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645115.1	Differs from Mb2074c and Rv2048c in several positions due to various substitutions, transitions and transversions in BCG Pasteur and BCG Tokyo
YP_002645120.1	F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein
YP_002645122.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_002645123.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif
YP_002645124.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif
YP_002645125.1	required for 70S ribosome assembly
YP_002645128.1	with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism
YP_002645131.1	catalyzes the interconversion of precorrin-8X and hydrogenobyrinate
YP_002645132.1	S-adenosyl-L-methionine-precorrin-2 methyl transferase, precorrin-3 methylase
YP_002645135.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription
YP_002645136.1	CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6
YP_002645137.1	Differs from Rv2071c by 1aa, M145I in BCG Pasteur and BCG Tokyo
YP_002645138.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 2029 bp deletion (H37Rv.2330073-2332101-*)(RD9) leads to the loss of the NH2 part of cobL, the entire Rv2073 and Rv2074, and the COOH part of Mb2100c. In addition, while cobL exists as a single gene in Mycobacterium tuberculosis strain H37Rv, in Mycobacterium bovis a frameshift due to a single base insertion (*-T) splits cobL into 2 parts, cobLa and cobLb
YP_002645139.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 2029 bp deletion (H37Rv.2330073-2332101-*)(RD9) leads to the loss of the NH2 part of cobL, the entire Rv2073 and Rv2074, and the COOH part of Mb2100c. In addition, while cobL exists as a single gene in Mycobacterium tuberculosis strain H37Rv, in Mycobacterium bovis a frameshift due to a single base insertion (*-T) splits cobL into 2 parts, cobLa and cobLb
YP_002645140.1	In Mycobacterium bovis AF2122/97, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 2029 bp deletion(RD9) leads to the loss of the COOH part of Mb2100c, the entire Rv2074 and Rv2073, and the NH2 part of cobL compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_002645144.1	Differs from Rv2078 by 1aa, G6E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645145.1	Differs from Rv2079 by 2aa, C47Y, L216P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645146.1	Differs from Rv2080 by 1aa, A23V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645147.1	In Mycobacterium bovis BCG Tokyo, insertion 5bp or 2bp compared to its homologs in Mycobacterium tuberculosis strain H37Rv or Mycobacterium bovis leads to a product with different C-terminal part. 5bp:GGGGG insertion in BCG Tokyo after 311:G of Mycobacterium bovis or Mycobacterium tuberculosis H37Rv(Rv2081c), 11bp:GGGGGGGGGGG insertion in BCG Pasteur after 311:G of Mycobacterium tuberculosis H37Rv. In Mycobacterium bovis, a 3 bp in-frame insertion (*-GGG) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (147 aa versus 146 aa).
YP_002645148.1	Differs from Mb2108 (721 aa) and from Rv2082 (721aa) by 26 codon in-frame deletion and from Rv2082 by 2aa, A183T, R612L in BCG Pasteur and BCG Tokyo
YP_002645149.1	Differs from Rv2083 by 1aa, V256L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645150.1	In Mycobacterium tuberculosis strain H37Rv, Rv2084 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo, a frameshift due to an 11bp insertion (*-GGCGTACACAC), splits Rv2084 into 2 parts
YP_002645156.1	In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 114 bp in-frame deletion leads to a shorter product compared to its ortholog in Mycobacterium tuberculosis strain H37Rv (355 aa versus 393 aa) and a 57 bp in-frame deletion leads to a shorter product compared to its ortholog in Mycobacterium bovis (355 aa versus 374 aa). Difference is due to copy number of tandem motif: DPTSGDPLHPAPPRLRSPL (or variant there of) near N-terminus. Also differs from Rv2090 by 1aa, L320F in BCG Pasteur and BCG Tokyo
YP_002645158.1	Differs from Rv2092c by 1aa, M178T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645160.1	TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_002645161.1	Differs from Mb2122c by 1aa, A267V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645164.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS36 and PE21 exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base insertion (*-c) leads to a single product more similar to PE_PGRS36. There is also a 3 bp in-frame deletion (GGC-*)
YP_002645166.1	Differs from Rv2101 by 3aa, L462M, Q601P, S652A in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002645172.1	Differs from Rv2109c by 2aa, P135R, G182R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645175.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 57 bp in-frame deletion at the NH2 part, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (535 aa versus 554 aa)
YP_002645176.1	Differs from Mb2137 by 1aa, S278L, and from Rv2113 by 1aa, P207T in BCG Pasteur and BCG Tokyo
YP_002645184.1	long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors
YP_002645185.1	catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis
YP_002645186.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 27 bp in-frame deletion leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 473 aa)
YP_002645187.1	Differs from Rv2124c by 1aa, V752I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methionine synthase, vitamin-B12 dependent isozyme, MS
YP_002645188.1	Differs from Rv2125 by 1aa, S33G in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645190.1	Differs from Rv2127 by 2aa, D9G, S44G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645193.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_002645199.1	BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell
YP_002645201.1	Differs from Mb2162 by 3aa, VQV348-350SRF, due to 7bp substitution in latter, tccaggt-gtccagg in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645202.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_002645213.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_002645215.1	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_002645216.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_002645217.1	In Mycobacterium bovis BCG Tokyo, 1bp deletion at 1402:C of Mycobacterium tuberculosis, Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, leads to a shortly larger product compared with its homolog in Mycobacterium tuberculosis (Rv2154c), Mycobacterium bovis, and BCG Pasteur (553aa vs 524aa) and leads to product with different C-terminal part.
YP_002645218.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_002645219.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_002645221.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_002645223.1	In Mycobacterium tuberculosis strain H37Rv, Rv2160A and Rv2160c exist as 2 genes with an overlap region between them. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 4 bp insertion (*-GGAA) leads to a single product
YP_002645225.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, in-frame deletions of 108 bp and 18 bp leads to a shorter product than in Mycobacterium tuberculosis strain H37Rv (490 aa versus 532 aa)
YP_002645227.1	Differs from Mb2188c by 1aa, V202A in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645229.1	MraZ; UPF0040; crystal structure shows similarity to AbrB
YP_002645235.1	Differs from Rv2174 and Mb2196 at 3'-end owing to frameshift due to 1 bp insertion (T) at position corresponding to H37Rv coordinates 2437401-2437402, and from Rv2174 by 1aa, S451A in BCG Pasteur and BCG Tokyo
YP_002645236.1	Differs from Rv2175c by 1aa, L17P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645237.1	Differs from Rv2176 by 1aa, A52S in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002645238.1	Differs from Rv2177c by 1aa, K115T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645239.1	Differs from Rv2178c by 1aa, E265D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645241.1	Differs from Rv2180c by 1aa, T156P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645248.1	In Mycobacterium tuberculosis strain H37Rv, fadD15 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to single base deletion (T-*) splits fadD15 into 2 parts.
YP_002645249.1	In Mycobacterium tuberculosis strain H37Rv, fadD15 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to single base deletion (T-*) splits fadD15 into 2 parts. Differs from Rv2187 by 2aa, I8T, E287G in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002645253.1	contains 3'-5'exonuclease domain
YP_002645254.1	Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_002645256.1	cytochrome c subunit
YP_002645257.1	Differs from Rv2195 by 1aa, I281M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645258.1	cytochrome b subunit
YP_002645259.1	Differs from Rv2197c by 1aa, S202A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645269.1	catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole
YP_002645270.1	catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole
YP_002645272.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_002645273.1	catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein
YP_002645275.1	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides
YP_002645277.1	Differs from Rv2215 and Mb2238 by 1aa, V517L in BCG Pasteur and BCG Tokyo
YP_002645279.1	lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein
YP_002645280.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_002645281.1	Differs from Rv2219 by 1aa, L74F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645284.1	catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme
YP_002645286.1	Differs from Rv2223c and Mb2247c by 1aa, S307A in BCG Pasteur and BCG Tokyo
YP_002645288.1	catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate
YP_002645289.1	Differs from Rv2226 and Mb2250 by 1aa, N299D andG31D, respectively, in BCG Pasteur and BCG Tokyo
YP_002645290.1	In Mycobacterium tuberculosis strain H37Rv, Rv2227 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 1bp to 2bp substitution (T-CC) splits Rv2227 in two parts
YP_002645291.1	In Mycobacterium tuberculosis strain H37Rv, Rv2227 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 1bp to 2bp substitution (T-CC) splits Rv2227 in two parts
YP_002645293.1	Differs from Rv2229c by 1aa, Q239R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645299.1	CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
YP_002645303.1	Differs from Rv2240c by 1aa, K259T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645304.1	E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC
YP_002645305.1	Differs from Rv2242 and Mb2266 by 1aa, T363A in BCG Pasteur and BCG Tokyo
YP_002645307.1	carries the fatty acid chain in fatty acid biosynthesis
YP_002645308.1	FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_002645309.1	FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_002645311.1	In Mycobacterium bovis and Mycobacterium tuberculosis, Rv2248 and Mb2272 exist as single gene. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, the ortholog is split into two parts owing to single base insertion in G-string (-G) at position equivalent to Mycobacterium tuberculosis position 2522481-2522482
YP_002645312.1	In Mycobacterium bovis and Mycobacterium tuberculosis, Rv2248 and Mb2272 exist as single gene. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, the ortholog is split into two parts owing to single base insertion in G-string (-G) at position equivalent to Mycobacterium tuberculosis position 2522481-2522482
YP_002645314.1	Differs from Mb2274c by 1aa, D68A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645315.1	In Mycobacterium tuberculosis H37Rv, Rv2250A and Rv2251 exist as 2 genes with an overlap region between them. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base deletion (G-*) leads to a single product
YP_002645316.1	involved in the biosynthesis of phosphatidylinositol mannosides (PIMs); the enzyme from Mycobacterium tuberculosis can phosphorylate a variety of amphipathic lipids
YP_002645318.1	Differs from Rv2254c by 1aa, V68A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645320.1	Differs from Rv2256c by 1aa, G26A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645325.1	In Mycobacterium tuberculosis strain H37Rv, Rv2262cand Rv2261c exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 2 bp deletion (CT-*) results in a single product
YP_002645331.1	Differs from Rv2268c and Mb2291c by 1aa, F203L in BCG Pasteur and BCG Tokyo
YP_002645333.1	Differs from Mb2293 by 1aa, P152L in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645337.1	Differs from Rv2274c by 1aa, M33I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645338.1	Differs from Rv2275 and Mb2298 by 1aa, A261E in BCG Pasteur and BCG Tokyo
YP_002645340.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 1358 bp deletion containing an IS6110 sequence, disrupts the 5' start of Rv2277c resulting in a slightly shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (299 aa versus 301 aa). Differs from Mb2300c by 1aa in BCG Pasteur and BCG Tokyo
YP_002645343.1	LysR-family
YP_002645347.1	In Mycobacterium tuberculosis strain H37Rv, Rv2286c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, an in-frame stop codon due to a single base transition (C-T) splits Rv2286c into 2 parts
YP_002645348.1	In Mycobacterium tuberculosis strain H37Rv, Rv2286c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, an in-frame stop codon due to a single base transition (C-T) splits Rv2286c into 2 parts
YP_002645352.1	In Mycobacterium tuberculosis strain H37Rv, Rv2290 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*), splits lppO into 2 parts, lppOa and lppOb
YP_002645353.1	In Mycobacterium tuberculosis strain H37Rv, Rv2290 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*), splits lppO into 2 parts, lppOa and lppOb
YP_002645354.1	In Mycobacterium bovis, truncation at the 5' start due to a 2 bp deletion (TG-*), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (256 aa versus 284 aa). Differs from Rv2291 by 1aa, A262E
YP_002645355.1	In Mycobacterium tuberculosis strain H37Rv, Rv2293c and Rv2292c exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base insertion (*-G) results in a single product
YP_002645361.1	molecular chaperone
YP_002645367.1	Differs from Rv2305 by 1aa, D148G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645368.1	Differs from Rv2306A by 1aa, V47I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645370.1	Differs from Rv2307c by 2aa, T24M, W235R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645374.1	Differs from Rv2308 by 1aa, V43G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645376.1	Differs from Rv2309A by 1aa, K53E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645383.1	Differs from Rv2316 by 1aa, L126V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645385.1	Differs from Rv2318 by 1aa, V354L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645386.1	Differs from Rv2319c and Mb2346c by 1aa, G105E in BCG Pasteur and BCG Tokyo
YP_002645388.1	C-terminus part
YP_002645389.1	N-terminus part
YP_002645390.1	Differs from Rv2323c by 1aa, T113A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645391.1	probably AsnC-family
YP_002645397.1	Differs from Rv2330c and Mb2357c by 1aa, A97S in BCG Pasteur and BCG Tokyo
YP_002645399.1	Differs from Rv2331A by 1aa, L46I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645400.1	malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate
YP_002645401.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, single base insertion (*-G) leads to a slightly longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (523 aa versus 537 aa). Also differs from Rv2333c by 2aa, Y69D, Q503H in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002645405.1	Differs from Rv2337c by 1aa, V119G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645407.1	In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (G-A) splits mmpL9 into 2 parts, mmpL9a and mmpL9b
YP_002645408.1	In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (G-A) splits mmpL9 into 2 parts, mmpL9a and mmpL9b
YP_002645409.1	Differs from Rv2340c and Mb2369c by 1aa, T222D in BCG Pasteur and BCG Tokyo
YP_002645412.1	synthesizes RNA primers at the replication forks
YP_002645413.1	dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate
YP_002645415.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 8963 bp deletion (RD5) leads to the loss of the NH2 part of Rv2346c, and the 9 following CDSs up to Rv2356 including the 3 phospolipases C enzymes plcC, plcB and plcA, compared to the homolog in Mycobacterium tuberculosis H37Rv
YP_002645416.1	Compared to Mycobacterium bovis, there has been a 2579bp bp deletion at position equivalent to M. bovis 2604493-2607071, this has resulted in an in-frame fusion of the 5'-end of PPE40 with the 3'-end of PPE71 probably due to a homologous recombination event between codons 68 and 174 of PPE40 as the PPE40 and PPE71 genes have identical 5'-ends (first 535 bp). Differs from Mb2376c(PPE71) by extra 11aa, insertion of A at position 68 due to 3bp insertion (present in PPE40) and STNVGSGNIG at position 307 due to 30 bp insertion. M. bovis BCG Pasteur and BCG Tokyo thus has three copies of tandem repeat STNVGSGNIG compared to two in Mb2376c. The 3'-end of PPE71 of M. bovis BCG Pasteur and BCG Tokyo have also been truncated as a result of the same deletion described in In Mycobacterium bovis, 8963 bp deletion (RD5)
YP_002645417.1	Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002645418.1	probably ArsR-family
YP_002645419.1	Differs from Rv2359 by 1aa, R64H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645420.1	Differs from Rv2360c by 1aa, T66A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645421.1	catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate
YP_002645422.1	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_002645423.1	catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia
YP_002645424.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_002645432.1	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_002645433.1	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_002645434.1	Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
YP_002645437.1	Differs from Rv2377c by 1aa, A69V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645439.1	Differs from Rv2379c by 1aa, D589E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645443.1	Differs from Rv2383c by 2aa, Q264R, P1253T, and from Mb2404c by 1aa, P1253T BCG Pasteur and BCG Tokyo
YP_002645444.1	salicyl-S-ArCP synthetase
YP_002645446.1	catalyzes conversion of chorismate to salicylate, in mycobactin siderophore construction; requires Mg(2+) for function
YP_002645448.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_002645450.1	Differs from Mb2411c by 1aa, I33T in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo
YP_002645452.1	catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite
YP_002645453.1	In Mycobacterium bovis BCG Pasteur and BCG Tokyo, duplication of 54 bp segment after codon 3 leads to additional 18 aa and two tandem copies of motif PATMQSAAMLRSGAIEAP, compared to its ortholog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis AF2122/97
YP_002645454.1	Differs from Rv2394 by 1aa Q396R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645455.1	In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, as in Mycobacterium bovis, a frameshift due to a single base insertion (*-T) splits Rv2395 into 2 parts. The frameshift occurs after the 44th codon
YP_002645456.1	In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-T) splits Rv2395 into 2 parts. BCG_2410 also differs from Rv2395 by 1aa, P396S in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002645457.1	Identical to Mb2418 of Mycobacterium bovis, including 3 bp deletion (GCC-*) that leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (360 aa versus 361 aa) due to deletion of A95 in BCG Pasteur and Tokyo. Also differs from Rv2396 by 2aa, N26S, S324N in BCG Pasteur. Differs from Rv2396 by 3aa, N26S, C218G, S324N in BCG Tokyo.
YP_002645459.1	Differs from Rv2398c by 1aa, A141G, and from Mb2420c by 1aa, R264H in BCG Pasteur and BCG Tokyo
YP_002645465.1	Differs from Rv2403c by 1aa, L127V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645466.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_002645469.1	member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions
YP_002645474.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_002645476.1	In Mycobacterium bovis, a single base insertion (*-T) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (523 aa versus 514 aa)
YP_002645477.1	Differs from Rv2415c by 1aa, L291R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645478.1	Differs from Mb2439c by 1aa, T76A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645481.1	Differs from Mb2442c by 1aa, A165V in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo
YP_002645482.1	Differs from Rv2420c and Mb2443c by insertion of 1aa, Pro, at position 126 due to 3bp insertion (GCG) at position equivalent to Mycobacterium bovis 2685985-2685986 in BCG Pasteur and BCG Tokyo
YP_002645483.1	transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria
YP_002645486.1	In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 2bp deletion (GT-*) splits Rv2424c into 2 parts. Differsfrom Rv2424c by 3aa, I172T, A173T and Y192H
YP_002645487.1	In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 2bp deletion (GT-*) splits Rv2424c into 2 parts
YP_002645489.1	Differs from Rv2426c by 1aa, L113F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645490.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_002645499.1	Differs from Rv2436 by 2aa, V274A, A282V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645501.1	catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers
YP_002645503.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_002645504.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_002645505.1	involved in the peptidyltransferase reaction during translation
YP_002645509.1	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate
YP_002645512.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_002645513.1	Differs from Rv2449c and Mb2476c by 1aa, C273R in BCG Pasteur and BCG Tokyo
YP_002645514.1	In Mycobacterum bovis BCG Tokyo, 1bp deletion leads to a shortly longer product compared with its homolog in Mycobacterium tuberculosis H37Rv (Rv2450c), Mycobacterium bovis, and BCG Pasteur (198aa vs 172aa), and leads to a product with different C-terminal part.
YP_002645515.1	Differs from Rv2451 by 1aa, D63N in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002645517.1	MobA; links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide; involved in molybdenum cofactor biosynthesis
YP_002645518.1	catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin
YP_002645521.1	binds and unfolds substrates as part of the ClpXP protease
YP_002645522.1	converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines
YP_002645523.1	Differs from Mb2486 by 1aa, M55I in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo
YP_002645524.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_002645525.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_002645526.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_002645529.1	catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity
YP_002645531.1	Differs from Rv2467 and Mb2494 by 1aa, M18I in Mycobacterium bovis BCG Pasteur.
YP_002645533.1	Differs from Rv2469c by 2aa, G28S, S99A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645534.1	oxygen-binding protein
YP_002645535.1	Differs from Rv2471 by 1aa, S206W in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645538.1	Differs from Mb2501c by 1aa, A30V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645540.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 3 bp deletion (cgg-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1623 aa versus 1624 aa). Differs from Rv2476c by 2aa, loss of A501 due to 3 bp deletion and G1042S
YP_002645541.1	ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence
YP_002645544.1	PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA
YP_002645545.1	Differs from Rv2483c by 1aa, G189C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; L-3-phosphoserine phosphatase, 1-acyl-sn-glycerol-3-phosphate acyltransferase
YP_002645546.1	Differs from Rv2484c by 1aa, D466G in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002645548.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002645549.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts, the first due to a single base insertion (*-C) and the second due to a single base deletion (G-*) splits PE_PGRS42 into 3 parts, PE_PGRS42a and PE_PGRS42b and PE_PGRS42d while in Mycobacterium bovis BCG Pasteur and BCG Tokyo, PE_PGRS42a and PE_GRRS42b are fused
YP_002645550.1	Differs from Rv2488c and Mb2515c by 1aa E535D in BCG Pasteur and BCG Tokyo; LuxR-family
YP_002645552.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS43 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 8 bp insertion (*-GGGGGGGG ) splits PE_PGRS43 into 2 parts, PE_PGRS43a and PE_PGRS43b while in Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 1bp insertion (equivalent to Mycobacterium tuberculosis H37Rv position 2804942-2804943) causes a different frameshift but at same place, 3bp:GCC deletion in BCG Pasteur after 2409:G of Mycobacterium bovis, 1bp:T deletion in BCG Tokyo at 2931:T of Mycobacterium bovis.
YP_002645553.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS43 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 8 bp insertion (*-GGGGGGGG ) splits PE_PGRS43 into 2 parts, PE_PGRS43a and PE_PGRS43b while in Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 1 bp insertion (equivalent to Mycobacterium tuberculosis H37Rv position 2804942-2804943) causes a different frameshift but at same place, 3bp:GCC deletion in BCG Pasteur after 2409:G of Mycobacterium bovis, 1bp:T deletion in BCG Tokyo at 2931:T of Mycobacterium bovis.
YP_002645555.1	Differs from Rv2492 by 1aa, D70A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002645558.1	Differs from Rv2495c by 2aa, A107T, W208R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002645559.1	Differs from Rv2496c by 1aa, S201G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002645565.1	Differs from Rv2502c by 2aa, S77G, L343F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645568.1	Differs from Rv2505c and Mb2533c by 1aa, A381T in BCG Pasteur and BCG Tokyo
YP_002645569.1	probably TetR-family
YP_002645574.1	3'-5' exoribonuclease specific for small oligoribonuclotides
YP_002645577.1	Differs from Rv2513 by 1aa, K122T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645583.1	Identical to Rv2519 but differs from Mb2548 by 1aa, G173A, due to 2bp substitution at position equivalent to Mycobacterium bovis 2803099-2803100 CC-GG in BCG Pasteur and BCG Tokyo.
YP_002645585.1	Differs from Mb2550 by 1aa, V122M in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645587.1	Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids
YP_002645592.1	Differs from Rv2528c by 1aa, L94P, and Mb2557c by 2aa, L94P, E259Q in BCG Pasteur and BCG Tokyo
YP_002645593.1	Differs from Mb2558 by 1aa, G94E in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645598.1	Regulates rRNA biosynthesis by transcriptional antitermination
YP_002645599.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_002645602.1	catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis
YP_002645603.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_002645604.1	catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_002645605.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_002645607.1	Differs from Rv2542 by 1aa, A211T in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002645609.1	In Mycobacterium bovis, Mycobacterium bovisBCG Pasteur, and BCG Tokyo, there is a 656 bp insertion, relative to Mycobacterium tuberculosis strain H37Rv, which leads to lppR gene, probably by duplication of llpA or lppB
YP_002645618.1	AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_002645620.1	similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function
YP_002645621.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002645625.1	Differs from Rv2559c by 1aa, D317G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645626.1	Differs from Rv2560 by 1aa, L210V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645627.1	In Mycobacterium tuberculosis strain H37Rv, Rv2561 and Rv2562 exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base deletion(g-*) results in a single product which is more similar to Rv2561
YP_002645631.1	In Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 2bp deletion (GC-*) splits Rv2566 into 2 parts. Differs from first part of Rv2566 by 3aa, S10G, S270A, L315V and from Mb2595 by 1aa, L315V in BCG Pasteur and BCG Tokyo
YP_002645632.1	In Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 2bp deletion (GC-*) splits Rv2566 into 2 parts. Differs from Rv2566 by 2aa, P67L, E326G, and from Mb2596 by 1aa, E326G in BCG Pasteur and BCG Tokyo
YP_002645633.1	Differs from Rv2567 by 1aa, R645Q in BCG Pasteur and BCG Tokyo
YP_002645637.1	Differs from Rv2571c and Mb2601c by 1aa, C68R in Mycobacterium bovis BCG Pasteur.
YP_002645638.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_002645643.1	In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, Rv2577 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (G-A) splits Rv2577 into 2 parts, Mb2607 and Mb2608
YP_002645645.1	catalyzes the cleavage of carbon-halogen bonds in aliphatic compounds forming a primary alcohol and a halide
YP_002645646.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_002645648.1	Differs from Rv2582 by 1aa, F66V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002645650.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_002645651.1	Differs from Rv2585c by 1aa, S462C
YP_002645652.1	forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF
YP_002645653.1	part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane
YP_002645654.1	member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex
YP_002645655.1	catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate
YP_002645656.1	Differs from Rv2590 by 1aa, Y309F, and from Mb2621 by 1aa, A1106T in BCG Pasteur and BCG Tokyo
YP_002645657.1	Differs from Rv2591 by extra 3 aa resulting from same 9 bp in-frame insertion as in Mycobacterium bovis(*-GGCGGCACC) and by 2aa S415G, D463G in BCG Pasteur and BCG Tokyo
YP_002645658.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_002645659.1	plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_002645660.1	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_002645662.1	Differs from Rv2596 by 1aa, R77C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645665.1	Differs from Rv2599 by 1aa, I12S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645666.1	First 64 aa identical to N-terminal part of Rv2600 and Mb2631 but then frameshifts due to 10bp deletion at position equivalent to Mycobacterium bovis coordinates 2895640-2895649. Results in BCG Pasteur and BCG Tokyo orthologs of Mb2631 and Rv2600 being in two parts
YP_002645667.1	All 59aa are identical to C-terminal part of Rv2600 and Mb2631 owing to frameshifts due to 10bp deletion at position equivalent to Mycobacterium bovis coordinates 2895640-2895649. Results in BCG Pasteur and BCG Tokyo orthologs of Mb2631 and Rv2600 being in two parts, both of which encode hydrophobic proteins
YP_002645668.1	catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine
YP_002645672.1	with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate
YP_002645673.1	Differs from Rv2605c by 1aa, L85F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645674.1	with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate
YP_002645675.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate
YP_002645676.1	Differs from Rv2608 by 1aa, S281P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645679.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA
YP_002645682.1	catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr)
YP_002645683.1	Differs from Mb2647 by 1aa, R57H in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo
YP_002645684.1	In Mycobacterium bovis, a 9 bp in-frame insertion (*-CCGCCGTTT) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 461 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 7bp deletion at position corresponding to M. bovis 2944835-2944841 splits PE_PGRS45 in two parts
YP_002645685.1	In Mycobacterium bovis, a 9 bp in-frame insertion (*-CCGCCGTTT) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 461 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 7bp deletion at position corresponding to M. bovis 2944835-2944841 splits PE_PGRS45 in two parts. Differs from Rv2615c by 1aa, V40A in BCG Pasteur and BCG Tokyo
YP_002645686.1	Differs from Rv2616 by 1aa, I72V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645691.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 3 bp deletion (GGG-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (223 aa versus 224 aa) due to deletion of 1aa after position 194
YP_002645697.1	Differs from Rv2627c by 1aa, G104R in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645698.1	Differs from Rv2628 by 1aa, L59S, and from Mb2661 by 1aa, P68R in BCG Pasteur and BCG Tokyo
YP_002645704.1	In Mycobacterium bovis BCG Pasteur, an in-frame insertion of 66 bp, leads to a longer product compared to Mycobacterium bovis and Mycobacterium tuberculosis strain H37Rv (800 aa versus 778 aa)
YP_002645710.1	probably ArsR-family
YP_002645712.1	probably ArsR-family
YP_002645713.1	Differs from Rv2643 by 1 aa A455V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645715.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 10982 bp deletion (RD11 region) leads to deletion of genes between Rv2645 and Rv2659c compared to Mycobacterium tuberculosis strain H37Rv
YP_002645724.1	Differs from Rv2668 by 2aa R3H and K162E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645728.1	Differs from Rv2672 by 1aa D317H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645733.1	catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX
YP_002645734.1	catalyzes the formation of coproporphyrinogen from uroporphyrinogen III
YP_002645735.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002645737.1	Differs from Rv2681 by 1aa V196A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645738.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_002645739.1	Differs from Rv2683 by 1aa, S84L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645741.1	Differs from Rv2685 by 1aa, G378A and Mb2704, by 1aa, G393C in BCG Pasteur and BCG Tokyo
YP_002645744.1	Differs from Rv2688c by 1aa, T156P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645746.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (t-c) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (663 aa versus 657aa)
YP_002645747.1	Differs from Rv2691 by 1aa, A117T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645748.1	Differs from Rv2692 by 1aa, V133I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645750.1	Differs from Rv2694c by 1aa, S68R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645752.1	Differs from Rv2696c by 1aa, N164D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645753.1	catalyzes the formation of dUMP from dUTP
YP_002645758.1	Differs from Rv2702 by 1aa, T203I in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002645759.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YP_002645765.1	Differs from Rv2709 by 1aa, S35T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645766.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase
YP_002645769.1	catalyzes the conversion of NADPH to NADH
YP_002645770.1	Differs from Rv2714 by 2aa, W181S, A245V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645775.1	Differs from Rv2719c by 1aa, H124Y in Mycobacteium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645776.1	Represses a number of genes involved in the response to DNA damage
YP_002645777.1	Differs from Rv2721c and Mb2740c by 2aa, S251G, A326T in BCG Pasteur and BCG Tokyo
YP_002645780.1	Differs from Rv2724c by 1aa, T127I, and from Mb2743c by 1aa, P33A in BCG Pasteur and BCG Tokyo
YP_002645781.1	Differs from Rv2725c and Mb2744c by 1aa, D218G in BCG Pasteur and BCG Tokyo
YP_002645782.1	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_002645783.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_002645785.1	Differs from Rv2729c by 3aa, L41F, E202A, V266A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645789.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_002645792.1	binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities
YP_002645793.1	these RecA proteins contain inteins; catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_002645799.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, deletions of a single base (t-*) and of 84 bp (H37Rv2.3054724-3054807-*) leads to a shorter product with a different 5' start compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Also has lost 174 bp compared to Mb2761
YP_002645800.1	In Mycobacterium tuberculosis strain H37Rv, Rv2742c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a 23bp insertion splits Rv2742c into two parts
YP_002645801.1	In Mycobacterium tuberculosis strain H37Rv, Rv2742c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a 23bp insertion splits Rv2742c into two parts
YP_002645803.1	Differs from Mb2765c by 1aa, K153Q in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645806.1	catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis
YP_002645809.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_002645812.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_002645813.1	flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor
YP_002645815.1	Differs from Rv2756c by 1aa, P306L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645821.1	In Mycobacterium tuberculosis strain H37Rv, Rv2762c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (C-T) splits Rv2762c into 2 parts
YP_002645822.1	In Mycobacterium tuberculosis strain H37Rv, Rv2762c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (C-T) splits Rv2762c into 2 parts
YP_002645824.1	ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived
YP_002645825.1	Differs from Rv2765 and Mb2787 by 1aa, I129M in BCG Pasteur and BCG Tokyo
YP_002645826.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_002645827.1	Differs from Rv2767c and Mb2789c by 1aa, L26S in BCG Pasteur and BCG Tokyo
YP_002645828.1	Differs from Rv2768c by 1aa, R263P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645829.1	Differs from Rv2769c by 2aa, S54P, M270V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645830.1	Differs from Rv2770c by 1aa, S194F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645831.1	Differs from Rv2771c by 1aa, P80L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002645833.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_002645839.1	In Mycobacterium bovis, a 24 bp deletion leads to a shorter product compared to its homolog in Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv (171 aa versus 179 aa) Differs from Rv2779c by 1aa, I9M, and 8 aa longer than Mb2801c; probably lrp/AsnC-family
YP_002645840.1	In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and in Mycobacterium bovis, a frameshift due to a single base deletion (A-*) splits ald into 2 parts, alda and aldb
YP_002645841.1	In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and in Mycobacterium bovis, a frameshift due to a single base deletion (A-*) splits ald into 2 parts, alda and aldb
YP_002645846.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_002645847.1	catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities
YP_002645848.1	Differs from Rv2787 and Mb2810 by 1aa, P78T
YP_002645849.1	Differs from Rv2788 by 1aa, A137D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645853.1	Differs from Mb2815c by 2aa, A17V, T80E in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645854.1	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs
YP_002645855.1	Differs from Rv2794c by 1aa, V87M in Mycobacterium tuberculosis CDC1551 in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645857.1	Differs from Rv2796c by 1aa, F159C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645860.1	In Mycobacterium bovis, a 3 bp insertion (*-GGT) leads to a slightly longer product compared to its homolog in Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv (210 aa versus 209 aa)
YP_002645865.1	Differs from Rv2804c by 2aa, T58A, V74A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645866.1	Differs from Rv2805 by 1aa, D4G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645868.1	Differs from Rv2807 by 2aa, V72E, T349M, and from Mb2830 by 1aa, T349M in BCG Pasteur and BCG Tokyo
YP_002645870.1	Differs from Rv2809 by 1aa, P46T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645872.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, Rv2812 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (TG-*) splits Rv2812 into 2 parts, Mb2835 and Mb2836. Differs from Rv2812 by 1 aa, G395R
YP_002645873.1	Differs from Rv2813 by 1aa, V76I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645878.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (c-t) introduces a premature stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (336 aa versus 382 aa)
YP_002645883.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 9 bp insertion (*-CGGCGATGT) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_002645884.1	Differs from Mb2848c by 1aa H56P in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645885.1	Differs from Rv2825c by 5aa, E2K, C162S, L189V, Q192T, E195A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645888.1	Differs from Mb2852c by 1aa E58A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645891.1	Differs from Rv2830c by 1aa, V56A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645892.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002645893.1	Differs from Rv2832c and Mb2856c by 1aa, L235F in BCG Pasteur and BCG Tokyo
YP_002645894.1	In mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base mutation (T->A) at corresponding position 3093840, in Mycobacterium tuberculosis H37Rv strain, leads to a stop codon and break ugpB in two parts. Differs from Rv2833c by 2aa, I111S, L174P in BCG Pasteur and BCG Tokyo
YP_002645896.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo and Mycobacterium tuberculosis strain H37Rv, ugpA exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) splits ugpA into 2 parts, ugpAaand ugpAb
YP_002645897.1	Differs from Rv2836c by 2aa, H157Q, L350P, and from Mb2861c by 1aa, H157Q in BCG Pasteur and BCG Tokyo
YP_002645899.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_002645900.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_002645902.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_002645903.1	in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins
YP_002645906.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_002645907.1	Differs from Rv2846c by 1aa, R15T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002645908.1	uroporphyrin-III C-methyltransferase, precorrin-2 oxidase, ferrochelatase
YP_002645909.1	responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid
YP_002645910.1	catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide
YP_002645911.1	Differs from Rv2850c by 2aa, Q273R, S446G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002645913.1	malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate
YP_002645914.1	Differs from Rv2853 by 3aa, N227K, G228R, D232G, and 18aa deletion, and from Mb2878 by 1aa, D184G, and same 18aa deletion in BCG Pasteur and BCG Tokyo
YP_002645916.1	catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide
YP_002645924.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential
YP_002645925.1	Differs from Rv2862c by 2aa, P18R, R50C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645931.1	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis
YP_002645932.1	Differs from Mb2894c by 1aa, T330A, and from Rv2869c by 2aa, F259V, T330A in BCG Pasteur and BCG Tokyo
YP_002645933.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_002645935.1	Differs from Rv2872 and Mb2897 by 1aa, T72A in BCG Pasteur and BCG Tokyo
YP_002645937.1	Differs from Rv2874 by 1aa, D672Y in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645940.1	Differs from Rv2877c by 1aa, H35Y in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002645942.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_002645944.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_002645945.1	Catalyzes the phosphorylation of UMP to UDP
YP_002645947.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-c) leads to a truncation resulting in a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (439 aa versus 460 aa)
YP_002645950.1	catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia
YP_002645951.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_002645952.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_002645956.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_002645958.1	Differs from Rv2896c by 2aa, G57E, A153S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002645961.1	involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth
YP_002645964.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_002645965.1	Differs from Rv2903c by 1aa, N2564D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002645966.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_002645968.1	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_002645969.1	Essential for efficient processing of 16S rRNA
YP_002645971.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_002645974.1	probably TetR-family
YP_002645979.1	Differs from Rv2917 by 1aa, L594R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002645980.1	catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; also involved in adenylylating and deadelnylyating GlnK
YP_002645984.1	Differs from Rv2922c by 2aa, R364L, G698R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002645985.1	catalyzes the hydrolysis of acylphosphate
YP_002645987.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_002645988.1	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_002645993.1	activates fatty acids by binding to coenzyme A
YP_002645994.1	Differs from Rv2931 at several positions in BCG Pasteur and BCG Tokyo
YP_002645995.1	Differs from Mb2957 and Rv2932 at several positions in BCG Pasteur and BCG Tokyo
YP_002645997.1	Differs from Rv2934 at several positions in BCG Pasteur and BCG Tokyo
YP_002645998.1	Differs from Rv2935 at several positions in BCG Pasteur and BCG Tokyo
YP_002645999.1	Differs from Rv2936 by 1aa, D309H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002646002.1	required for PDIM synthesis; phthiocerol and phthiodiolone dimycocerosate esters are scaffolds used for virulence-enhancing lipids; proposed to catalyze diesterification of phthiocerol and phthiodolone with mycocerosate; functions in polyketide synthesis
YP_002646004.1	activates fatty acids by binding to coenzyme A
YP_002646009.1	In Mycobacterium tuberculosis H37Rv, pks1 and pks15 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-G) results in a single product that is more similar to pks1. Differs from Rv2946c by 2aa, G1779V, V1859A, and from Rv2947c by 2aa, A333V, R374G in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo.
YP_002646010.1	activates fatty acids by binding to coenzyme A
YP_002646012.1	activates fatty acids by binding to coenzyme A
YP_002646016.1	Differs from Rv2954c and Mb2978c by 1aa, Q194R in BCG Pasteur and BCG Tokyo
YP_002646017.1	Differs from Rv2955c by 1aa, H27R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646018.1	Differs from Rv2956 by 1aa, T237I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646020.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_002646026.1	produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine
YP_002646027.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_002646029.1	biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate
YP_002646034.1	Differs from Rv2971 by 1aa, H152N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646036.1	catalyzes branch migration in Holliday junction intermediates
YP_002646037.1	In Mycobacterium tuberculosis H37Rv, Rv2975c and Rv2974c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 2 bp deletion (CG-*) results in a single product that is more similar to Rv2974c
YP_002646038.1	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YP_002646039.1	catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP
YP_002646041.1	Differs from Rv2979c by 3aa, R14P, A79T, G151D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646043.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_002646044.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_002646046.1	catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate
YP_002646048.1	Differs from Rv2986c and Mb3010c by 9aa deletion atposition 137 in BCG Pasteur and BCG Tokyo
YP_002646049.1	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_002646050.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_002646052.1	Differs from Mb3014c by 1aa, A217E in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646053.1	Differs from Rv2991 by 1aa, T93A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646054.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_002646057.1	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_002646058.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_002646059.1	Differs from Rv2997 by 1aa S108C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646062.1	Differs from Rv2999 by 1aa, L212M in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646064.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_002646065.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_002646066.1	acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate
YP_002646069.1	Differs from Rv3006 by 1aa, D219G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646072.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_002646073.1	catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis
YP_002646074.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_002646075.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain
YP_002646077.1	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB
YP_002646081.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 56 bp deletion leads to a products lightly different at the N-terminus part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (434 aa versus 437 aa). Differs from Rv3018c by 1aa, A53V, and Mb3043c by 1aa, L328V in BCG Pasteur, and BCG Tokyo
YP_002646085.1	In Mycobacterium tuberculosis H37Rv, PPE47 and PPE48 exist as 2 separate genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-G) leads to a single product.
YP_002646087.1	Differs from Rv3023c by 1aa T9A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646088.1	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_002646092.1	Differs from Rv3028c by 1aa, V312A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646096.1	Differs from Rv3032 and Mb3058 by 1aa, P380Q in BCG Pasteur and BCG Tokyo
YP_002646101.1	Differs from Mb3062c by 1aa, Q63R in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646102.1	Differs from Rv3037c by 1aa, A7D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646104.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002646107.1	Differs from Rv3042c by 2aa, S70A, E116G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646115.1	probably AsnC-family
YP_002646116.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_002646117.1	in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF
YP_002646118.1	glutaredoxin-like protein
YP_002646121.1	probably TetR-family
YP_002646122.1	involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
YP_002646124.1	probably TetR-family
YP_002646125.1	Differs from Mb3085 by 1aa, E44K and Rv3059 by 2aa, E44K, G445D in BCG Pasteur and BCG Tokyo
YP_002646126.1	probably GntR-family
YP_002646127.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, fadE22 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-C) splits fadE22 into 2 parts, fadE22a and fadE22b. Differs from Mb3087c and from Rv3061c by 2aa, E488K, C497S in BCG Pasteur and BCG Tokyo
YP_002646128.1	catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA
YP_002646129.1	Differs from Rv3063 by 3aa, C402G, S559R, P600L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646132.1	probably DeoR-family
YP_002646133.1	Differs from Rv3067 and Mb3094 by 1aa A3T in BCG Pasteur and BCG Tokyo
YP_002646134.1	catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate
YP_002646135.1	may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling
YP_002646136.1	may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling
YP_002646143.1	Differs from Rv3077 by 1aa R311G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646146.1	Differs from Rv3080c by 1aa, V217A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646147.1	Differs from Rv3081 and Mb3108 by 1aa, A108V in BCG Pasteur and BCG Tokyo
YP_002646148.1	AraC/XylS family; Differs from Rv3082c by 1aa, C322R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646149.1	Differs from Mb3110 by 1aa, S81I and from Rv3083 by 2aa, S81I, I94V in BCG Pasteur and BCG Tokyo
YP_002646150.1	Differs from Rv3084 and Mb3111 by 1aa, G276S in BCG Pasteur and BCG Tokyo
YP_002646153.1	Differs from Rv3087 by 1aa, V447L, and from Mb3114 by 1aa, T158A in BCG Pasteur and BCG Tokyo
YP_002646158.1	Differs from Mb3119c by 1 aa, I237M in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646159.1	Differs from Rv3093c by 1aa W210C in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002646162.1	Differs from Rv3097 by 1aa G28E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646163.1	Differs from Rv3097c by 1aa A58G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably triacyl glycerol lipase
YP_002646164.1	Differs from Rv3098c by 1aa E117D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646166.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_002646167.1	Differs from Rv3101c by 1aa, S171N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646171.1	recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1
YP_002646172.1	Differs from Rv3106 by 2aa, I141V, D385N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646174.1	Differs from Mb3135 by 1aa I145V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646175.1	Differs from Mb3136 by 1aa, T324A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646177.1	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis
YP_002646179.1	Differs from Rv3113 by 3aa, C11W, E134G, R191L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646180.1	Differs from Rv3114 by 1aa, P11S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646183.1	In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a large deletion of 2775 bp (RD12) leads to the loss of the COOH part of cysA3, the following CDSs, sseC1, moaE1, Rv3120 and a large part of cyp141 except the COOH end, compared to the homolog in Mycobacterium tuberculosis strain H37Rv
YP_002646184.1	Differs from Rv3122 by 1aa, S156R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646185.1	Differs from Rv3123 by 1aa, Q40R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646186.1	Differs from Rv3124 and Mb3147 by 1aa, G159E in BCG Pasteur and BCG Tokyo
YP_002646187.1	In Mycobacterium bovis BCG Pasteur and BCG Tokyo, PPE49 has incurred a single base deletion in codon 272 compared to Rv3125c and Mb3148c leading to frameshift, and two products of 282 and 104 aa, compared to 391 in others
YP_002646188.1	In Mycobacterium bovis BCG Pasteur and BCG Tokyo, PPE49 has incurred a single base deletion in codon 272 compared to Rv3125c and Mb3148c leading to frameshift, and two products of 282 and 104 aa, compared to 391 in others. Differs from Rv3125c by 1aa, V38A
YP_002646190.1	Differs from Rv3127 by 1aa, C95F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646191.1	In Mycobacterium tuberculosis strain H37Rv, Rv3128c exists as a single gene with an in-frame amber stop codon. In Mycobacterium bovis, BCG Pasteur, and BCG Tokyo, Rv3128c is split into 2, Mb3151c and Mb3152c
YP_002646192.1	In Mycobacterium tuberculosis strain H37Rv, Rv3128c exists as a single gene with an in-frame amber stop codon. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, Rv3128c is split into 2 genes. Differs from Mb3152c by 1aa, V166G in BCG Pasteur and BCG Tokyo
YP_002646196.1	Differs from Rv3132c by 1aa, T283I in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002646197.1	probably LuxR/UhpA-family
YP_002646199.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a large 1337 bp insertion (I-RD08) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (381 aa versus 132 aa). Differs from Mb3159 by 1aa, K213E in BCG Pasteur. Differ from Mb3159 by 1aa, G256E in BCG Tokyo
YP_002646201.1	Differs from Rv3137 by 1aa, L168P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646202.1	Differs from Rv3138 by 2aa, N110S, P271T, and from Mb3162 by 2aa, F257S, P270L in BCG Pasteur and BCG Tokyo
YP_002646206.1	Differs from Mb3166c by 1aa, H133Q in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646208.1	Differs from Rv3144c by 1aa, G226S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646209.1	Catalyzes the transfer of electrons from NADH to quinone
YP_002646210.1	The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen
YP_002646211.1	Catalyzes the transfer of electrons from NADH to quinone
YP_002646212.1	Catalyzes the transfer of electrons from NADH to quinone
YP_002646213.1	Catalyzes the transfer of electrons from NADH to quinone
YP_002646215.1	Catalyzes the transfer of electrons from NADH to quinone
YP_002646216.1	Catalyzes the transfer of electrons from NADH to quinone
YP_002646217.1	Catalyzes the transfer of electrons from NADH to quinone
YP_002646218.1	Catalyzes the transfer of electrons from NADH to quinone
YP_002646219.1	Catalyzes the transfer of electrons from NADH to quinone
YP_002646220.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_002646221.1	Catalyzes the transfer of electrons from NADH to quinone
YP_002646222.1	Catalyzes the transfer of electrons from NADH to quinone
YP_002646223.1	In Mycobacterium bovis BCG pasteur, BCG Tokyo, and Mycobacterium bovis, albeit a 2146 bp insertion occurs overlapping the NH2-terminal part, this leads to an equivalent product, compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Rv3159c by 2aa, deletion of A64, V87A, and from Mb3183c by 1aa, V87A in BCG Pasteur and BCG Tokyo.
YP_002646224.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, an insertion of 2146 bp exists between PPE53 and Rv3160c compared to Mycobacterium tuberculosis strain H37Rv. This leads to an additional gene, PPE70 equivalent to MT3248 from Mycobacterium tuberculosis strain CDC1551. Differs from Mb3184c by 1aa, addition of A64 in BCG Pasteur and BCG Tokyo.
YP_002646225.1	probably TetR-family
YP_002646226.1	Differs from Rv3161c by 1aa, L62V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646227.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (T-*), leads to a longer product with different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_002646228.1	Differs from Mb3188c by 1aa, D341E in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646229.1	Differs from Mb3189c by 1aa, E20G in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646231.1	Differs from Rv3166c and Mb3191c by 1aa, A202S in BCG Pasteur and BCG Tokyo
YP_002646232.1	probably TetR-family
YP_002646233.1	Differs from Mb3193 by 1aa, W65R in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646236.1	Differs from Rv3171c by 1aa, M201T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646238.1	probably TetR/AcrR-family
YP_002646239.1	Differs from Rv3174 by 1aa, A9V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646240.1	catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia
YP_002646241.1	In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo and Mycobacterium bovis, a frameshift due to a single base deletion (C-*) splits mesT into 2 parts, mesTa and mesTb.
YP_002646242.1	In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (C-*) splits mesT into 2 parts, mesTa and mesTb
YP_002646243.1	non-haem peroxidase
YP_002646253.1	Differs from Rv3190c by 2aa, P138L, A330V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646256.1	Differs from Rv3193c by 2aa, E356Q, Q843R, and from Mb3215c by 1aa, E356Q in BCG Pasteur and BCG Tokyo
YP_002646265.1	can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates
YP_002646266.1	Differs from Rv3200c by 1aa, D12N in Mycobacterium bovis , Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646268.1	Differs from Rv3202c by 1aa, A748V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646271.1	Differs from Rv3204 by 1aa, A34T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646273.1	The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation
YP_002646274.1	Differs from Rv3207c by 1aa, N157D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646275.1	probably TetR-family
YP_002646279.1	Differs from Mb3237 by 1aa, V17A in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo
YP_002646280.1	Differs from Mb3238 by 1aa, G225D, and from Rv3212 by 2aa, G225D, A250V in BCG Pasteur and BCG Tokyo
YP_002646281.1	Differs from Rv3213c by 1aa, E144K in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646282.1	forms a homodimer in Mycobacterium tuberculosis; belongs to the dPGM superfamily
YP_002646288.1	Differs from Rv3220c by 1aa, N47D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646292.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response
YP_002646296.1	Differs from Rv3225c by 1aa T306A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646298.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_002646299.1	Differs from Rv3228, Mb3257 and BCG_3351 by 1aa, D169G in Mycobacterium bovis BCG Pasteur.
YP_002646301.1	Differs from Rv3230c by 1aa, C105R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646302.1	In DU2 of BCG Pasteur, the second copy (BCG_3354c) is truncated.
YP_002646304.1	In Mycobacterium tuberculosis H37Rv, Rv3234c and Rv3233c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis (Mb3262c), a single base insertion (*-G) leads to a single product that is more similar to Rv3234c. In Mycobacterium BCG Tokyo, two bases insertion, (*-G) and (*-T) leads to two products that is more similar to Rv3234c.
YP_002646305.1	In Mycobacterium tuberculosis H37Rv, Rv3234c and Rv3233c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-G) leads to a single product that is more similar to Rv3234c. In Mycobacterium BCG Tokyo, two bases insertion, (*-g) and (*-T) leads to two products that is more similar to Rv3234c.
YP_002646310.1	Differs from Mb3267c by 1aa, R867H in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646311.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_002646313.1	Differs from Rv3242c and Mb3270c by 1aa, S89L in Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002646315.1	Differs from Rv3244c by 2aa, G142D, L394S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646316.1	Differs from Rv3245c by 1aa, L517M in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646318.1	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP)
YP_002646319.1	catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine
YP_002646320.1	probably TetR-family
YP_002646328.1	converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells
YP_002646332.1	catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO)
YP_002646333.1	catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0)
YP_002646336.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, an in-frame deletion of 12 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (297 aa versus 301aa)
YP_002646337.1	Differs from Rv3266c by 1aa, P257S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646343.1	Differs from Mb3300 by 1aa, R259G, and from Rv3272 by 2aa, R259G, S347N in BCG Pasteur and BCG Tokyo
YP_002646346.1	Differs from Rv3275c by 1aa, R125G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646347.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_002646348.1	Differs from Rv3277 by 1 aa, L272S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646349.1	Differs from Rv3278c by 1aa, K160E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur. Differs from Rv3278c by 2aa, T54I, K160E in Mycobacterium bovis BCG Tokyo.
YP_002646350.1	Differs from Rv3279c by 1aa, N211D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; biotin--[acetyl-CoA-carboxylase] synthetase
YP_002646351.1	Differs from Rv3280 by 1aa, A448V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646352.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, an in-frame deletion of 63 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (156 aa versus 177aa). Loss of tandem repeat SRVSGTNEVSDGNETNNPAPV
YP_002646353.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_002646354.1	Differs from Mb3311 by 1aa, G170D in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646356.1	biotin carboxylase, biotin carboxyl carrier protein, accA3
YP_002646357.1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is a general stress response regulator; expressed in stationary phase and under nitrogen depletion and cold shock
YP_002646361.1	catalyzes the formation of 2-aminoadipate 6-semiladehyde and glutamate from lysine and 2-oxoglutarate
YP_002646362.1	Differs from Rv3291c by 1aa, V22A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably AsnC-family
YP_002646364.1	Differs from Rv3293 by 1aa, C273G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646366.1	probably TetR-family
YP_002646367.1	Differs from Rv3296 by 3aa, M719V, N818D, E1059K in Mycobacterium bovis and Mycobacterium bovis BCG Pasteur. Differs from Rv3296 by 4aa, T719V, M796L, N818D, E1059K in Mycobacterium bovis BCG Tokyo.
YP_002646370.1	Differs from Rv3299c by 1aa, S204G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646371.1	Differs from Mb3328c by 1aa, D52N in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646372.1	Differs from Rv3301c and Mb3329c by 1aa, S74A in BCG Pasteur and BCG Tokyo
YP_002646374.1	catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity
YP_002646378.1	catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation
YP_002646379.1	Differs from Rv3308 by 1aa, G440S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646380.1	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_002646381.1	Differs from Rv3310 by 1aa, A171T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646385.1	catalyzes the formation of inosine from adenosine
YP_002646386.1	Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
YP_002646387.1	Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis
YP_002646388.1	cytochrome b-556 subunit
YP_002646389.1	Differs from Rv3317 by 1aa, L54V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrophobic membrane anchor subunit
YP_002646390.1	Differs from Mb3328c by 1aa, D52N in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646391.1	Differs from Rv3301c and Mb3329c by 1aa, S74A in Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002646393.1	catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity
YP_002646397.1	catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation
YP_002646398.1	Differs from Rv3308 by 1aa, G440S in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002646399.1	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_002646400.1	Differs from Rv3310 by 1aa, A171T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646404.1	catalyzes the formation of inosine from adenosine
YP_002646405.1	Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
YP_002646406.1	Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis
YP_002646407.1	cytochrome b-556 subunit
YP_002646408.1	Differs from Rv3317 by 1aa, L54V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrophobic membrane anchor subunit
YP_002646409.1	Differs from Mb3328c by 1aa, D52N in Mycobacterium tuberculosis H37Rv, BCG Pasteur, and BCG Tokyo
YP_002646410.1	Differs from Rv3301c and Mb3329c by 1aa, S74A in BCG Pasteur and BCG Tokyo
YP_002646412.1	catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity
YP_002646416.1	catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation
YP_002646417.1	Differs from Rv3308 by 1aa, G440S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646418.1	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_002646419.1	Differs from Rv3310 by 1aa, A171T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646423.1	catalyzes the formation of inosine from adenosine
YP_002646424.1	Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
YP_002646425.1	Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis
YP_002646426.1	cytochrome b-556 subunit
YP_002646427.1	Differs from Rv3317 by 1aa, L54V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrophobic membrane anchor subunit
YP_002646428.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol
YP_002646429.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase
YP_002646434.1	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis
YP_002646435.1	Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv
YP_002646436.1	Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv
YP_002646437.1	Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv but present in CDC1551 (CDS not annotated)
YP_002646438.1	Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv but present in CDC1551 (CDS not annotated)
YP_002646439.1	Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv
YP_002646440.1	Belongs to the RvD5 region. Absent from Mycobacterium tuberculosis strain H37Rv. In Mycobacterium bovis BCG Tokyo, 1b insertion leads to a shortly larger product compared with its homolog in Mycobacterium bovis (Mb3359c), Mycobacterium bovis, and BCG Pasteur (BCG_3396c) (232aa vs 214aa) and leads to product with different C-terminal part. 3Gs in BCG Tokyo, 2Gs in BCG Pasteur.
YP_002646442.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription
YP_002646443.1	Differs from Rv3329 by 1aa, H122Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646445.1	Differs from Mycobacterium bovis (Mb3364) and Mycobacterium bovis BCG Tokyo by 5aa in-frame deletion at position 465, and from Rv3331 by same deletion and 1aa, L423P in Mycobacterium bovis BCG Pasteur.
YP_002646449.1	probably MerR-family
YP_002646450.1	Differs from Rv3335c and Mb3368c by 1aa, V86A in BCG Pasteur and BCG Tokyo.
YP_002646451.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002646452.1	In Mycobacterium tuberculosis strain H37Rv, Rv3337 and Rv3338 exist as 2 genes with an overlap region between them. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-T) leads to a single product
YP_002646453.1	Converts isocitrate to alpha ketoglutarate
YP_002646454.1	catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol
YP_002646455.1	Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine
YP_002646457.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 3555 bp in-frame deletion (RD19) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Mb3375c by 1aa, A513V and from Rv3343c by several transitions in BCG Pasteur and BCG Tokyo.
YP_002646458.1	In Mycobacterium tuberculosis strain H37Rv, PE_PGRS50 and PE_PGRS49 exists as a single gene. In Mycobacterium bovis, a single base deletion (G-*) splits PE_PGRS50 into 2 parts, PE_PGRS50a and PE_PGRS50b and a single base deletion (C-*) leads to PE_PGRS49 and PE_PGRS50b existing as a single product. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, the first deletion is absent leading to an unique single gene comprising PE_PGRS50 and PE_PGRS49
YP_002646460.1	In Mycobacterium tuberculosis strain H37Rv, PPE55 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (G-*) splits PPE55 into 2 parts, PPE55a and PPE55b. Differs from Rv3347c by many aa substitutions and from Mb3380c by 1 aa, P1089S in BCG Pasteur and BCG Tokyo.
YP_002646463.1	In Mycobacterium tuberculosis strain H37Rv, PPE56 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, 2 frameshifts due to single base transversion (C-A) and a single base deletion (G-*) splits PPE56 into 3 parts, PPE56a, PPE56b and PPE56d. Differs from Rv3350c and Mb3385c by 2aa deletion at position 291 in BCG Pasteur and BCG Tokyo.
YP_002646467.1	Differs from Rv3354 by 1aa, A112V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646469.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_002646477.1	Differs from Rv3364c and Mb3399c, by 1aa, L22P in BCG Pasteur and BCG Tokyo
YP_002646480.1	In Mycobacterium bovis, insertions of 105 bp and of 9 bp (*-GGCAGCGGT) lead to longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (626 aa versus 588 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, there is no 105 bp insertion but the 9 bp insertion is presentat codon 404. Differs also from Rv3367 by 1aa, S412G in BCG Pasteur and BCG Tokyo
YP_002646483.1	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase.
YP_002646484.1	Differs from Rv3371 by 2aa, G339R, V368I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646486.1	In Mycobacterium tuberculosis H37Rv, echA18 and echA18' exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transversion (t-g) leads to a single product
YP_002646489.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a 4 bp to 3 bp substitution (CAAT-AAC) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv
YP_002646490.1	Differs from Rv3378c and Mb3412c by 1aa, A137V in BCG Pasteur and BCG Tokyo
YP_002646491.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_002646493.1	Differs from Rv3383c by 1aa, G132V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002646498.1	In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur and BCG Tokyo, insertions of 60 bp and 78 bp, and deletions of 75 bp and 9 bp (CGGCGGCGC-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (750 aa and 749 aa versus 731 aa). Differs from Mb3420 by 1aa insertion, A205 in BCG Pasteur and BCG Tokyo
YP_002646499.1	Differs from Mb3421c by 1aa, P172L in Mycobacteirum tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646502.1	Differs from Rv3392c by 1aa, S112N in Mycobacteirum bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646505.1	Differs from Rv3395c by 2aa, V3A, M104V in Mycobacteirum bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646507.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_002646510.1	Differs from Rv3399 by 1aa, E330A in Mycobacterium tuberculosis CDC1551, Mycobacteirum bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646512.1	Differs from Mb3434 by 1aa, R658H in Mycobacterium bovis BCG Pasteur and by 2aa, R658H, R750L in Mycobacterium bovis BCG Tokyo.
YP_002646513.1	In Mycobacterium bovis BCG Pasteur and BCG Tokyo, and Mycobacterium bovis, a single base transversion (c-g) leads to a shorter product. Differs from Mb3436c by 1aa, R154C in BCG Pasteur and BCG Tokyo
YP_002646518.1	Differs from Rv3408 by 1aa, L46S in Mycobacteirum bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646520.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_002646521.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_002646524.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase
YP_002646527.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth
YP_002646528.1	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_002646529.1	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_002646533.1	converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer
YP_002646535.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a large deletion of 4926 bp (RD6) leads to the loss of the COOH part of PPE57, and the following CDSs, PPE58, Rv3427c, Rv3428c and the NH2-part of PPE59 compared to Mycobacterium tuberculosis strain H37Rv
YP_002646536.1	Differs from Mb3460c by 1aa, R233H in Mycobacteirum tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646539.1	Differs from Mb3463c by 1aa, A436 deleted, and from Rv3433c by 2aa, A436 deleted, A442S in Mycobacterium bovis BCG Pasteur. Differs from Rv3433c by 1aa, A442S in Mycobacterium bovis BCG Tokyo.
YP_002646540.1	Differs from Mb3464c by 1aa, A193T in Mycobacteirum tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646542.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_002646543.1	Differs from Rv3437 by 1aa P84L in Mycobacteirum bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646547.1	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_002646548.1	forms a direct contact with the tRNA during translation
YP_002646549.1	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_002646553.1	Differs from Rv3444c by 1 aa, G1082S and Mb3477c by 1 aa G1159S in BCG Pasteur and BCG Tokyo
YP_002646554.1	Differs from Mb3478 by 1aa A265D in Mycobacteirum tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646557.1	Differs from Rv3451 and Mb3481 by deletion of 1aa,262R in BCG Pasteur and BCG Tokyo
YP_002646559.1	In Mycobacterium tuberculosis H37Rv, Rv3453 and Rv3454 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base deletion (T-*) results in a single product that is more similar to Rv3454. Differs from Mb3483 by 1aa, V328I in BCG Pasteur and BCG Tokyo
YP_002646560.1	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability
YP_002646561.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_002646562.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_002646563.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_002646564.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_002646565.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_002646566.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif
YP_002646567.1	stimulates the activities of the other two initiation factors, IF-2 and IF-3
YP_002646571.1	Differs from Rv3466 by 4aa, T56A, T63A, L91R, I131V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646572.1	Differs from Rv3467 by 6aa, E134K, G245A, D262G, R275H, K276N, E315K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646573.1	Differs from Rv3468c by 1aa, V62I in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002646574.1	catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate
YP_002646575.1	Differs from Mb3499c by 1aa, G421E in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646576.1	Differs from Mb3500c by 1aa, C155W in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646579.1	Differs from Rv3476c by 2aa, F81L, V144A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646580.1	Differs from Rv3477 by 1aa, A26V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646582.1	In Mycobacterium tuberculosis strain H37Rv, Rv3479 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and BCG Tokyo, and Mycobacterium bovis, a 713 bp deletion (RD18) splits Rv3479 into 2 parts, Mb3507 and Mb3508. Differs from Rv3479 by 1aa, R174L in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002646583.1	In Mycobacterium tuberculosis strain H37Rv, Rv3479 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 713 bp deletion (RD18) splits Rv3479 into 2 parts, Mb3507 and Mb3508. Differs from Rv3479 by 1aa, N344T in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002646584.1	In Mycobacterium tuberculosis strain H37Rv (Rv3480c), BCG Pasteur and BCG Tokyo, exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (GT-*) splits Rv3480c into 2 parts, Mb3509c and Mb3510c. Differs from Rv3480c and Mb3510c by 1aa, N205D
YP_002646586.1	In Mycobacterium bovis BCG Pasteur (BCG_3546c) and BCG Tokyo, a single base insertion (C) at position equivalent to Mycobacterium tuberculosis H37Rv position 3901442-3901443 leads to frameshift and longer product of 496 aa compared to Rv3482c, len: 260 aa
YP_002646592.1	Differs from Rv3488 by 1aa, R98G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002646594.1	Differs from Rv3490 by 1aa, L334V in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo.; UDP-forming
YP_002646598.1	Differs from Rv3494c by 1aa, G245D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002646601.1	Differs from Mb3527c and Rv3497c by 1aa, P46T in BCG Pasteur and BCG Tokyo.
YP_002646606.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_002646609.1	Differs from Rv3505 by 1aa V218A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.
YP_002646610.1	activates fatty acids by binding to coenzyme A
YP_002646611.1	In Mycobacterium bovis, insertions of 18 bp, 72 bp and 9 bp (*-CGGCGGCAC), and deletions of 90 bp, 54 bp and 18 bp, and Mycobacterium bovis BCG Pasteur and BCG Tokyo, insertions of 18 bp, 81 bp and 9 bp (*-CGGCGGCAC), and deletions of 90 bp, 27 bp and 18 bp, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1360 aa and 1372 aa versus 1381 aa). Differs from Mb3537 by 2 insertions of 9aa and 3aa and by 1aa, N599D. Differs from Rv3507 by several insertions, deletions and by 2aa, N599D, G742D in BCG Pasteur. Differs from Mb3537 by 2 insertions of 9aa and 3aa in BCG Tokyo. Differs form Rv3507 by several insertions, deletions and by 1aa, G742D in BCG Tokyo.
YP_002646612.1	In Mycobacterium bovis BCG Pasteur and BCG Tokyo, several insertions lead to a longer product compared to its homolog in Mycobacterium bovis (2094 aa in BCG Pasteur and 2055 aa in BCG Tokyo versus 1460 aa). The PE_PGRS54 gene of BCG Tokyo (6153bp) is 132bp shorter than that of BCG Pasteur (6285bp). There are two repeats of 465bp in BCG Tokyo and one such repeat in BCG Pasteur, as well as three repeats of 552bp in BCG Tokyo and four repeats in BCG Pasteur.
YP_002646613.1	thiamine-pyrophosphate requiring enzyme
YP_002646615.1	In Mycobacterium tuberculosis H37Rv, PE_PGRS55 and PE_PGRS56 exist as 2 genes. In Mycobacterium bovis, a 344bp insertion results in a single product which is more similar to PE_PGRS55. In Mycobacterium bovis BCG Pasteur and BCG Tokyo two deletions of 138bp and 246bp lead to a shorter product in BCG Pasteur compared to its homolog Mycobacterium bovis (1810 aa versus 1938 aa). Also differs from Mb3541 by 3aa, D628A, D743A and D857A. In BCG Tokyo, the PE_PGRS55 gene (5088bp, 1695aa) is 345bp shorter than that of BCG Pasteur (5433bp). As 345bp is the length of a repeat in the gene, the difference reflected the copy number of both BCG strains.
YP_002646617.1	In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a deletion of 111 bp and an insertion of 360 bp (361bp in BCG Tokyo) lead to a longer product compared to its homolog Mycobacterium bovis (2094aa versus 1460aa). Also differs from Mb3543 by 2aa, S80L and T93A in BCG Pasteur. In BCG Tokyo, a deletion of 117 bp and an insertion of 345 bp, 2bp, and T, A, insertions after 1958:G, 1970:C of BCG Pasteur (BCG_3577), and 1bp, G, deletion at 1963:G of BCG Pasteur (BCG_3577), lead to two products, 689aa and 284aa. Also differs from Mb3543 by 2aa, S80L and T93A in BCG Tokyo.
YP_002646618.1	In Mycobacterium bovis BCG Pasteur a deletion of 111 bp and an insertion of 360 bp lead to a longer product compared to its homolog Mycobacterium bovis (2094aa versus 1460aa). Also differs from Mb3543 by 2aa, S80L and T93A. In BCG Tokyo, 2bp, T, A, insertions after 1958:G and 1970:C of BCG Pasteur (BCG_3577), 1bp, G, deletion at 1963:G of BCG_3577. The PE_PGRS57 of BCG Tokyo divided into 2 parts, 689aa and 284aa.
YP_002646619.1	activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence
YP_002646620.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002646622.1	In Mycobacterium tuberculosis strain H37Rv, cyp142 exists as a single gene. In Mycobacterium bovis, BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*) splits cyp142 into 2 parts,cyp142a and cyp142b
YP_002646623.1	In Mycobacterium tuberculosis strain H37Rv, cyp142 exists as a single gene. In Mycobacterium bovis, BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*) splits cyp142 into 2 parts, cyp142a and cyp142b
YP_002646626.1	Differs from Rv3521 by 1aa D295N in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646627.1	Differs from Rv3522 by 1aa I324T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646628.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_002646639.1	catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate
YP_002646640.1	catalyzes the formation of acetyl-CoA from acetalaldehyde
YP_002646642.1	initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione
YP_002646651.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_002646653.1	Differs from Rv3548c by 1aa V218M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646655.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002646656.1	Differs from Rv3551 by 1aa, S7A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646660.1	Differs from Rv3555c by 1aa R268W in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646661.1	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation
YP_002646662.1	probably TetR-family
YP_002646664.1	Differs from Rv3559c by 1aa V222A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646666.1	activates fatty acids by binding to coenzyme A
YP_002646668.1	Differs from Rv3563 by 2aa R105Q and S275W in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646670.1	catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate
YP_002646673.1	Differs from Rv3567c by 1aa T179I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646674.1	Differs from Mb3599c by 1aa Q177R in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo
YP_002646676.1	Differs from Rv3570c by 1aa D18N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646680.1	probably TetR-family
YP_002646681.1	probably LacI-family
YP_002646682.1	Differs from Rv3576 by 1aa N118D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646684.1	Differs from Rv3578 by 1aa S319A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646685.1	Differs from Rv3579c by 1aa , A302E in Mycobacterium bovis BCG Pasteur and BCG Tokyo. Mb3610c is longer due to frameshift and differs by 1aa V178M in Mycobacterium bovis.
YP_002646686.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_002646687.1	catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
YP_002646688.1	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers
YP_002646689.1	Differs from Rv3583 by 1 aa, R13H in BCG Tokyo.
YP_002646691.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_002646692.1	non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair
YP_002646693.1	Shorter than Rv3587c and Mb3618c by 1aa, P at 240 in BCG Pasteur and BCG Tokyo
YP_002646694.1	Differs from Mb3619c by 1aa I79T in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo
YP_002646699.1	Differs from Rv3593 by 2 aa, V159A, S186N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646701.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base deletion (a-*) and a 27bp insertion (*-GCGCGCCGGGGCCACCGTTTCCGCCGG), lead to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (492 aa versus 439 aa)
YP_002646704.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_002646705.1	type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP
YP_002646706.1	Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5)
YP_002646707.1	catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine
YP_002646709.1	Differs from Rv3604c by G153V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646714.1	involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer
YP_002646716.1	Identical to Rv3611 in BCG Pasteur. In Mycobacterium bovis and BCG Tokyo, a 111bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis (180 aa versus 217aa).
YP_002646721.1	Differs from Rv3616c by 2aa, V4A, I192T and Mb3646c by 2aa, V4A, V153A in BCG Pasteur and BCG Tokyo
YP_002646722.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 5894 bp deletion (RD8) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (171 aa versus 240 aa)
YP_002646723.1	Differs by 2 aa from Rv3624c et Mb3648c A111T, N122D in Mycobacterium bovis BCG Pasteur. Differs by 1 aa from Rv3624c et Mb3648c A111T in Mycobacterium bovis BCG Tokyo.
YP_002646726.1	Differs from Rv3627c by 2 aa, V45A, V81A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646729.1	Differs from Rv3630 by 1aa, T40A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646730.1	possibly glycosyltransferase
YP_002646738.1	Differs from Rv3639c by 1 aa, N53K in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002646739.1	Differs from Rv3640c by 1aa, E296G in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002646743.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_002646745.1	catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity
YP_002646748.1	Differs from Rv3649 by 2aa, P93L, D677G, and from Mb3673 by D677G in BCG Pasteur and BCG Tokyo
YP_002646752.1	In Mycobacterium tuberculosis strain H37Rv, a frameshift due to an in-frame insertion of 126 bp leads to a longer product than in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo. Shorter than Mb3677 due to 18 bp in-frame deletion, removes 6 codons
YP_002646754.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base deletion (c-*) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (99 aa versus 125 aa)
YP_002646759.1	Differs from Rv3660c by 1aa, L30P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646760.1	Differs from Rv3661 by 1aa, P40S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646761.1	Differs from Rv3662c by 1aa, T34A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646765.1	Differs from Rv3666c by 2aa, R4Q, Q443R and to Mb3690c by 1aa, E451G in BCG Pasteur and BCG Tokyo
YP_002646769.1	Differs from Rv3671c by 3aa, T165N, L359F, V363I and from Mb3695c by 3aa, T165N and L359F in BCG Pasteur and BCG Tokyo
YP_002646774.1	Differs from Rv3676 and Mb 3700 by 2aa, P47L, K178E in Mycobacterium bovis BCG Pasteur. Differs from Rv3676 and Mb3700 by 2aa, E178K, V184A in Mycobacterium bovis BCG Tokyo; probably crp/fnr-family
YP_002646784.1	Differs from Rv3685c by 1aa, Q136E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo
YP_002646786.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, truncation at the 5' start due to a single base transversion (G-T) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (81 aa versus 122 aa)
YP_002646788.1	Differs from Rv3689 by 1aa, L119V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646792.1	Differs from Rv3693 by 2aa, V178L, P214A in BCG Tokyo.
YP_002646795.1	Converts glycerol and ADP to glycerol-3-phosphate and ADP
YP_002646796.1	Differs from Rv3697c by 1aa, R34G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646798.1	Differs from Rv3698 by 3aa, I66M, R233P, A288V and from Mb3724 by 1aa, A288V in BCG Pasteur and BCG Tokyo
YP_002646804.1	gamma-glutamylcystein synthetase, gamma-ECS, GCS, gamma-glutamyl-L-cysteine synthetase
YP_002646809.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_002646810.1	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.
YP_002646811.1	Protein is 190 aa longer than Rv3710, and 57 aalonger than Mb3737 due to differences in copy number of 19codon repeat at 3'-end
YP_002646812.1	3'-5' exonuclease of DNA polymerase III
YP_002646813.1	Differs from Rv3712 by 2aa, S200G, T351K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646816.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_002646820.1	Differs from Rv3719 by 1aa, A12T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646822.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_002646823.1	Differs from Rv3722c and Mb3749c by 1aa, Y314H in BCG Pasteur and BCG Tokyo
YP_002646825.1	In Mycobacterium tuberculosis, Rv3724A and Rv3724B exist as 2 genes with an overlap region between them. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a single base deletion (T-*) leads to a single product
YP_002646826.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base insertion (*-A) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (333 aa versus 309 aa)
YP_002646827.1	Differs from Rv3726 by 1aa, S251R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646828.1	Differs from Rv3727 by 1aa, M86V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646829.1	Differs from Rv3728 by 1aa, R464G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646830.1	Differs from Rv3729 by 2aa, I170V, S269P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646832.1	catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth
YP_002646837.1	Differs from Rv3736 and Mb3763 by 1aa, K76E in BCG Pasteur and BCG Tokyo.; probably AraC/XylS-family
YP_002646838.1	Differs from Rv3737 by 1aa, G40D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.
YP_002646839.1	Differs from Rv3740c by 1aa, C422R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.
YP_002646843.1	probably ArsR-family
YP_002646847.1	Differs from Rv3748 by 1aa, D107G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.
YP_002646852.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (t-c) leads to a longer product with a different 5' start compared to its homolog in Mycobacterium tuberculosis strain H37Rv(173 aa versus 166 aa)
YP_002646853.1	catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate
YP_002646858.1	Differs from Rv3759c by 2aa, P85L, V176A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.
YP_002646861.1	Differs from Rv3762c by 1aa, H345Y and from Mb3788c by 1aa, V161G in BCG Pasteur and BCG Tokyo
YP_002646863.1	Differs from Rv3764c by 2aa, R45H, R246C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.
YP_002646869.1	Differs from Rv3770c by 1aa, A98P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.
YP_002646873.1	Differs from Rv3772 by 1aa, A142T in Mycobacterium bovis, BCG Pasteur and BCG Tokyo.
YP_002646874.1	In Mycobacterium tuberculosis Rv3773c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo, a frameshift due to a single base insertion (*-A) splits Rv3773c in two parts
YP_002646875.1	In Mycobacterium tuberculosis strain H37Rv, Rv3773c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-A) splits Rv3773c into 2 parts
YP_002646876.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_002646879.1	Differs from Rv3777 by 1aa, A160V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646890.1	Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation
YP_002646895.1	Differs from Rv3793 by 1aa, I270T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646897.1	Differs from Rv3795 by 2aa, S13N, A378E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646898.1	Differs from Rv3796 by 1aa, I320T in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002646900.1	In Mycobacterium tuberculosis strain H37Rv (Rv3798), Mycobacterium bovis BCG Pasteur (BCG_3860), and BCG Tokyo, exist as a single gene. In Mycobacterium bovis, a frameshift due to a 11 bp deletion splits Rv3798 into 2 parts, Mb3827 and Mb3828. In Mycobacterium bovis, a frameshift due to a 11 bp deletion splits Rv3798 into 2 parts, Mb3827 and Mb3828
YP_002646902.1	Differs from Rv3800c by 2aa, G523A, N650S and from Mb3829c by 1aa, N650S in BCG Pasteur and BCG Tokyo
YP_002646903.1	activates fatty acids by binding to coenzyme A
YP_002646907.1	Differs from Rv3805c by 1aa, V327I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646908.1	catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate
YP_002646915.1	Differs from Rv3813c by 1aa, T83M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646916.1	3-bp:GGC deletion in BCG Tokyo after (188-190):GGC of Rv3814c
YP_002646922.1	Differs from Rv3820c by 1aa, I463T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646923.1	Differs from Rv3821 by 2aa, N106D, T120A
YP_002646924.1	Corresponds to Rv3822/Mb3852 but is missing 1bp after codon 122. Differs from Rv3822 by 2aa, Y55C, T103N, in first part (and by 1aa, V92A, in the second part)
YP_002646925.1	Corresponds to 3'-part of Rv3822/Mb3852 due to missing bp after codon 122. Differs from Rv3822 by 1aa, V92A (and by 2aa, Y55C, T105N, in first part)
YP_002646926.1	Differs from Rv3823c by 2aa, R235G, A526V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646928.1	Differs from Rv3825c and Mb3855c by 1aa, G829V in BCG Pasteur and BCG Tokyo
YP_002646929.1	activates fatty acids by binding to coenzyme A
YP_002646930.1	Differs from Rv3827c by 1aa, A251T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646932.1	Differs from Rv3829c by 1aa, D55E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646933.1	probably TetR-family
YP_002646936.1	Differs from Rv3833 by 1aa, I105V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably AraC-family
YP_002646937.1	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002646938.1	Differs from Rv3835 and Mb3865 by 1 aa, Y79N in BCG Pasteur and BCG Tokyo, and frameshift due to extra C in C-string that changes C-terminus in BCG Pasteur.
YP_002646939.1	In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base insertion (*-G) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (116 aa versus 137 aa)
YP_002646941.1	catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis
YP_002646942.1	Differs from Rv3839 by 1aa, S122P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646946.1	Differs from Rv3843c by 2aa, R11G, H92R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646949.1	Differs from Rv3846 by 1aa, T205I
YP_002646951.1	Differs from Rv3848 by 1aa, I194V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646956.1	regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity
YP_002646958.1	TetR-family
YP_002646961.1	glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate
YP_002646962.1	Differs from Rv3859c by 1aa, E553Q in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002646963.1	In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base deletion leads to a shorter product compared to its homologs in Mycobacterium tuberculosis and Mycobacterium bovis
YP_002646967.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and in Mycobacterium bovis, two in-frame insertion of 36 and 12bp, leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (418 aa versus 402 aa)
YP_002646971.1	Differs from Rv3868 by 1aa, V243A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646974.1	Differs from Rv3871 and Mb3901 by deletion of 101 codons after codon 480 due to BCG-specific RD1 deletion
YP_002646976.1	Differs from Rv3881c by 7 codon stretch due to 1bp deletion and 1 bp insertion in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646978.1	Differs from Rv3883c by 1aa, A37T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646979.1	Differs from Rv3884c by 1aa, G215E in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646980.1	Differs from Rv3885c by 1aa, P133L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646983.1	Has no counterpart in Mycobacterium bovis owing to deletion of 2405bp between positions 4307384..4307385
YP_002646984.1	Has no counterpart in Mycobacterium bovis owing to deletion of 2405bp between positions 364165-364166
YP_002646985.1	In Mycobacterium bovis, a deletion of 2406 bases leads to the loss of the NH2 part of Rv3887c, the entire Rv3888c and the COOH part of Rv3889c compared to Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur
YP_002646986.1	In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and in Mycobacterium bovis, a frameshift due to a single base deletion (C-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (124 aa versus 95 aa)
YP_002646987.1	Differs from Rv3891c by 1aa, A49T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646988.1	Differs from Rv3892c by 2aa, K19T, I206M and from Mb3921c by 1aa I206M in BCG Pasteur and BCG Tokyo
YP_002646990.1	In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-C), splits Rv3894c into 2 parts
YP_002646991.1	In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-C), splits Rv3894c into 2 parts. Differs from first part of Rv3984c by 1aa, P258R in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002646992.1	Differs from Rv3895c by 1aa, G356D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646993.1	Differs from Rv3896c by 3aa, G83D, V186I, K193Q, and by frameshift due to 1bp deletion leading to shorter product (288 aa versus 302 aa) in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646994.1	In Mycobacterium tuberculosis, Rv3898c and Rv3897c exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (T-C) leads to a single product
YP_002646995.1	In Mycobacterium tuberculosis, Rv3899c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur , and BCG Tokyo, a frameshift due to a single base deletion (C-*) splits Rv3899c into 2 parts, Mb3928c and Mb3929c with the former being the more likely product
YP_002646996.1	Differs from Rv3900c by 1aa, A18P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002646997.1	Differs from Rv3901c by 1aa, W21L, and frameshift due to 2bp deletion at 3'-end, and from Mb3931c by frameshift only in BCG Pasteur and BCG Tokyo
YP_002647000.1	Differs from Rv3904c by 1aa, V82M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002647001.1	In Mycobacterium bovis, and Mycobacteium bovis BCG Pasteur, and BCG Tokyo, a single base transition (G-A) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (57 aa versus 103 aa)
YP_002647005.1	Differs from Rv3909 by 3aa, R7G, S399N, V538A and from Mb3939 by 1aa G25A in BCG Pasteur and BCG Tokyo
YP_002647006.1	Differs from Rv3910 by 1aa, A480V in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo
YP_002647007.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase
YP_002647009.1	Differs from Rv3913 by 1aa, G57D
YP_002647015.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_002647016.1	Differs from Rv3920c by 1aa, W110R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo
YP_002647017.1	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_002647019.1	protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates
YP_002647020.1	in Escherichia coli transcription of this gene is enhanced by polyamines