-- dump date 20140619_151603 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 561275000001 SEQ_END SEQ_END NC_012207.1 4371711 4371711 DR NC_012207.1; contig end 4371711..4371711 Mycobacterium bovis BCG str. Tokyo 172 YP_002643051.1 CDS dnaA NC_012207.1 1 1524 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1..1524 Mycobacterium bovis BCG str. Tokyo 172 7561459 YP_002643052.1 CDS dnaN NC_012207.1 2052 3260 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2052..3260 Mycobacterium bovis BCG str. Tokyo 172 7561499 YP_002643053.1 CDS recF NC_012207.1 3280 4437 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 3280..4437 Mycobacterium bovis BCG str. Tokyo 172 7561507 YP_002643054.1 CDS JTY_0004 NC_012207.1 4434 4997 D Differs from Mb0004 by 1aa, S16L in BCG Pasteur and BCG Tokyo; hypothetical protein 4434..4997 Mycobacterium bovis BCG str. Tokyo 172 7561558 YP_002643055.1 CDS gyrB NC_012207.1 5123 7267 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 5123..7267 Mycobacterium bovis BCG str. Tokyo 172 7560958 YP_002643056.1 CDS gyrA NC_012207.1 7302 9818 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 7302..9818 Mycobacterium bovis BCG str. Tokyo 172 7563292 YP_002643057.1 CDS JTY_0007 NC_012207.1 9914 10828 D Differs from Mb0007 by 1aa, I272V in BCG Pasteur and BCG Tokyo; hypothetical protein 9914..10828 Mycobacterium bovis BCG str. Tokyo 172 7563291 YP_002643058.1 CDS JTY_0008 NC_012207.1 11874 12311 R Differs from Rv0008c by 1aa, P145S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(11874..12311) Mycobacterium bovis BCG str. Tokyo 172 7563955 YP_002643059.1 CDS ppiA NC_012207.1 12468 13016 D iron-regulated peptidyl-prolyl cis-trans isomerase A 12468..13016 Mycobacterium bovis BCG str. Tokyo 172 7560960 YP_002643060.1 CDS JTY_0010 NC_012207.1 13222 13557 R In Mycobacterium bovis BCG Pasteur and BCG Tokyo, and Mycobacterium bovis, a single base deletion (g-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (111 aa versus 141 aa); hypothetical protein complement(13222..13557) Mycobacterium bovis BCG str. Tokyo 172 7560806 YP_002643061.1 CDS JTY_0011 NC_012207.1 13713 13994 R integral membrane protein involved in inhibition of the Z-ring formation; septation inhibitor protein complement(13713..13994) Mycobacterium bovis BCG str. Tokyo 172 7560961 YP_002643062.1 CDS JTY_0012 NC_012207.1 14088 14876 D Differs from Rv0012 by 2aa, E105K, R233C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 14088..14876 Mycobacterium bovis BCG str. Tokyo 172 7560962 YP_002643063.1 CDS trpG NC_012207.1 14913 15611 D aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 14913..15611 Mycobacterium bovis BCG str. Tokyo 172 7560963 YP_002643064.1 CDS pknB NC_012207.1 15589 17469 R transmembrane serine/threonine-protein kinase B complement(15589..17469) Mycobacterium bovis BCG str. Tokyo 172 7561633 YP_002643065.1 CDS pknA NC_012207.1 17466 18761 R transmembrane serine/threonine-protein kinase A complement(17466..18761) Mycobacterium bovis BCG str. Tokyo 172 7562429 YP_002643066.1 CDS pbpA NC_012207.1 18758 20233 R penicillin-binding protein complement(18758..20233) Mycobacterium bovis BCG str. Tokyo 172 7562428 YP_002643067.1 CDS rodA NC_012207.1 20230 21639 R cell division protein complement(20230..21639) Mycobacterium bovis BCG str. Tokyo 172 7562518 YP_002643068.1 CDS ppp NC_012207.1 21636 23180 R Differs from Rv0018c by 3aa, L3R, A455S, S463P in Mcobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; serine/threonine phosphatase complement(21636..23180) Mycobacterium bovis BCG str. Tokyo 172 7561594 YP_002643069.1 CDS JTY_0019 NC_012207.1 23269 23736 R hypothetical protein complement(23269..23736) Mycobacterium bovis BCG str. Tokyo 172 7560811 YP_002643070.1 CDS TB39.8 NC_012207.1 23860 25425 R Differs from Mb0020c by 2aa, G47R, Y250H, and from Rv0020c by 3aa, G222D, C298Y, Q378R, and deletion of 6aa (EQRGYP) at position 246 in BCG Pasteur and BCG Tokyo; hypothetical protein complement(23860..25425) Mycobacterium bovis BCG str. Tokyo 172 7560964 YP_002643071.1 CDS JTY_0021 NC_012207.1 25894 26862 R Differs from Rv0021c by 1aa, P277A in Mcobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(25894..26862) Mycobacterium bovis BCG str. Tokyo 172 7562818 YP_002643072.1 CDS whiB5 NC_012207.1 27004 27423 R transcriptional regulator whiB-like complement(27004..27423) Mycobacterium bovis BCG str. Tokyo 172 7560965 YP_002643073.1 CDS JTY_0023 NC_012207.1 27576 28346 D transcriptional regulatory protein 27576..28346 Mycobacterium bovis BCG str. Tokyo 172 7561693 YP_002643074.1 CDS JTY_0024 NC_012207.1 28343 29176 D In Mycobacterium tuberculosis strain H37Rv, and other mycobacteria, Rv0024 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (C-*) splits Rv0024 into 2 parts; hypothetical protein P60-related protein 28343..29176 Mycobacterium bovis BCG str. Tokyo 172 7560966 YP_002643075.1 CDS JTY_0026 NC_012207.1 29225 29587 D Differs from Rv0025 by 1aa, L73P in Mcobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 29225..29587 Mycobacterium bovis BCG str. Tokyo 172 7560968 YP_002643076.1 CDS JTY_0027 NC_012207.1 29702 31135 D In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 4 bp insertion (*-ATCG) leads to a longer protein with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (477 aa versus 448 aa). Differs from Rv0026 by 1aa, P93Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 29702..31135 Mycobacterium bovis BCG str. Tokyo 172 7560969 YP_002643077.1 CDS JTY_0028 NC_012207.1 31173 31490 D hypothetical protein 31173..31490 Mycobacterium bovis BCG str. Tokyo 172 7560970 YP_002643078.1 CDS JTY_0029 NC_012207.1 31498 31803 D hypothetical protein 31498..31803 Mycobacterium bovis BCG str. Tokyo 172 7560971 YP_002643079.1 CDS JTY_0030 NC_012207.1 32041 33138 D Differs from Rv0029 by 1aa, N190H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 32041..33138 Mycobacterium bovis BCG str. Tokyo 172 7560972 YP_002643080.1 CDS JTY_0031 NC_012207.1 33208 33537 D hypothetical protein 33208..33537 Mycobacterium bovis BCG str. Tokyo 172 7560973 YP_002643081.1 CDS JTY_0032 NC_012207.1 33566 33778 D remnant of a transposase 33566..33778 Mycobacterium bovis BCG str. Tokyo 172 7560974 YP_002643082.1 CDS bioF2 NC_012207.1 34279 36594 D 8-amino-7-oxononanoate synthase 34279..36594 Mycobacterium bovis BCG str. Tokyo 172 7560975 YP_002643083.1 CDS acpA NC_012207.1 36591 36854 D acyl carrier protein 36591..36854 Mycobacterium bovis BCG str. Tokyo 172 7562070 YP_002643084.1 CDS JTY_0035 NC_012207.1 36851 37246 D hypothetical protein 36851..37246 Mycobacterium bovis BCG str. Tokyo 172 7563931 YP_002643085.1 CDS fadD34 NC_012207.1 37243 38931 D fatty-acid-CoA synthetase, fatty-acid-CoA synthase; fatty-acid-CoA ligase 37243..38931 Mycobacterium bovis BCG str. Tokyo 172 7560976 YP_002643086.1 CDS JTY_0037 NC_012207.1 39132 39812 R Differs from Mb0037c and Rv0036c by 1aa in BCG Pasteur and BCG Tokyo, L186P in BCG Pasteur, and at C-terminal end due to frameshift resulting from 1 bp deletion at position equivalent to Mycobacterium tuberculosis H37Rv, 39228-39228, after codon 202 in BCG Pasteur and Tokyo.; hypothetical protein complement(39132..39812) Mycobacterium bovis BCG str. Tokyo 172 7563350 YP_002643087.1 CDS JTY_0038 NC_012207.1 39860 41185 R integral membrane protein complement(39860..41185) Mycobacterium bovis BCG str. Tokyo 172 7560977 YP_002643088.1 CDS JTY_0039 NC_012207.1 41287 41895 D hypothetical protein 41287..41895 Mycobacterium bovis BCG str. Tokyo 172 7560978 YP_002643089.1 CDS JTY_0040 NC_012207.1 41987 42334 R Differs from Rv0039c by 1aa, F24C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein complement(41987..42334) Mycobacterium bovis BCG str. Tokyo 172 7560979 YP_002643090.1 CDS mtc28 NC_012207.1 42416 43348 R proline rich 28 kDa antigen; proline rich protein complement(42416..43348) Mycobacterium bovis BCG str. Tokyo 172 7560980 YP_002643091.1 CDS leuS NC_012207.1 43545 46454 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 43545..46454 Mycobacterium bovis BCG str. Tokyo 172 7563566 YP_002643092.1 CDS JTY_0043 NC_012207.1 46564 47190 R MarR-FAMILY; transcriptional regulatory protein complement(46564..47190) Mycobacterium bovis BCG str. Tokyo 172 7562817 YP_002643093.1 CDS JTY_0044 NC_012207.1 47349 48083 R probably GntR-family; transcriptional regulatory protein complement(47349..48083) Mycobacterium bovis BCG str. Tokyo 172 7560981 YP_002643094.1 CDS JTY_0045 NC_012207.1 48216 49010 R oxidoreductase complement(48216..49010) Mycobacterium bovis BCG str. Tokyo 172 7560982 YP_002643095.1 CDS JTY_0046 NC_012207.1 49026 49922 R hydrolase complement(49026..49922) Mycobacterium bovis BCG str. Tokyo 172 7560983 YP_002643096.1 CDS ino1 NC_012207.1 50004 51107 R Differs from Mb0047c by 1aa, T120I, and from Rv0046c by 2aa, T120I, G190R; myo-inositol-1-phosphate synthase complement(50004..51107) Mycobacterium bovis BCG str. Tokyo 172 7560984 YP_002643097.1 CDS JTY_0048 NC_012207.1 51168 51710 R hypothetical protein complement(51168..51710) Mycobacterium bovis BCG str. Tokyo 172 7562792 YP_002643098.1 CDS JTY_0049 NC_012207.1 51811 52680 R Differs from Rv0048c by 1aa, A250V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(51811..52680) Mycobacterium bovis BCG str. Tokyo 172 7560985 YP_002643099.1 CDS JTY_0050 NC_012207.1 52814 53227 D hypothetical protein 52814..53227 Mycobacterium bovis BCG str. Tokyo 172 7560986 YP_002643100.1 CDS ponA1 NC_012207.1 53646 55691 D In Mycobacterium bovis BCG Pasteur and BCG Tokyo, insertion of 3 codons after position 632 leads to a slightly longer product compared to its homologs in Mycobacterium tuberculosis strain H37Rv (681 aa versus 678 aa) and Mycobacterium bovis AF2122/97 (681 aa versus 680 aa). In addition, differs from Rv0050 by 1aa, L6P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; bifunctional penicillin-binding protein 1A/1B 53646..55691 Mycobacterium bovis BCG str. Tokyo 172 7560987 YP_002643101.1 CDS JTY_0052 NC_012207.1 55688 57370 D transmembrane protein 55688..57370 Mycobacterium bovis BCG str. Tokyo 172 7562140 YP_002643102.1 CDS JTY_0053 NC_012207.1 57402 57965 D hypothetical protein 57402..57965 Mycobacterium bovis BCG str. Tokyo 172 7560988 YP_002643103.1 CDS rpsF NC_012207.1 58184 58474 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 58184..58474 Mycobacterium bovis BCG str. Tokyo 172 7560989 YP_002643104.1 CDS ssb NC_012207.1 58578 59072 D binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 58578..59072 Mycobacterium bovis BCG str. Tokyo 172 7560733 YP_002643105.1 CDS rpsR NC_012207.1 59114 59368 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 59114..59368 Mycobacterium bovis BCG str. Tokyo 172 7561807 YP_002643106.1 CDS rplI NC_012207.1 59401 59859 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 59401..59859 Mycobacterium bovis BCG str. Tokyo 172 7560746 YP_002643107.1 CDS JTY_0058 NC_012207.1 59888 60409 D hypothetical protein 59888..60409 Mycobacterium bovis BCG str. Tokyo 172 7561609 YP_002643108.1 CDS dnaB NC_012207.1 60388 63012 D unwinds double stranded DNA; these Mycobacterial enzymes appear to contain inteins; replicative DNA helicase 60388..63012 Mycobacterium bovis BCG str. Tokyo 172 7560990 YP_002643109.1 CDS JTY_0060 NC_012207.1 63192 63884 D hypothetical protein 63192..63884 Mycobacterium bovis BCG str. Tokyo 172 7561500 YP_002643110.1 CDS JTY_0061 NC_012207.1 63901 64959 D hypothetical protein 63901..64959 Mycobacterium bovis BCG str. Tokyo 172 7560991 YP_002643131.1 CDS JTY_0062 NC_012207.1 64983 65408 D hypothetical protein 64983..65408 Mycobacterium bovis BCG str. Tokyo 172 7560992 YP_002643132.1 CDS celA1 NC_012207.1 65544 66686 D Differs from Mb0063 by 1aa, A72D, and from Rv0062 by 2aa, A72D, V106I in BCG Pasteur and BCG Tokyo; endoglucanase; cellulase 65544..66686 Mycobacterium bovis BCG str. Tokyo 172 7560993 YP_002643133.1 CDS JTY_0064 NC_012207.1 66915 68354 D oxidoreductase 66915..68354 Mycobacterium bovis BCG str. Tokyo 172 7562092 YP_002643134.1 CDS JTY_0065 NC_012207.1 68612 71551 D Differs from Mb0065 by 1aa, T435I, and from Rv0064 by 4aa, T435I, D457G, F550V, P906R in BCG Pasteur and BCG Tokyo; hypothetical protein 68612..71551 Mycobacterium bovis BCG str. Tokyo 172 7560994 YP_002643135.1 CDS JTY_0066 NC_012207.1 71618 71857 D Differs from Rv0064A by 1aa, V48A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; antitoxin 71618..71857 Mycobacterium bovis BCG str. Tokyo 172 7560995 YP_002643136.1 CDS JTY_0067 NC_012207.1 71850 72251 D hypothetical protein 71850..72251 Mycobacterium bovis BCG str. Tokyo 172 7560996 YP_002643137.1 CDS icd2 NC_012207.1 72303 74540 R Differs from Rv0066c by 1aa, N117K in in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; isocitrate dehydrogenase complement(72303..74540) Mycobacterium bovis BCG str. Tokyo 172 7560997 YP_002643138.1 CDS JTY_0069 NC_012207.1 74658 75227 R possibly TetR-family; transcriptional regulatory protein complement(74658..75227) Mycobacterium bovis BCG str. Tokyo 172 7563340 YP_002643139.1 CDS JTY_0070 NC_012207.1 75330 76241 D Differs from Rv0068 by 1aa, L214V in Mycobacterium bovis, Mycobacterium tuberculosis CDC1551, BCG Pasteur, and BCG Tokyo.; short chain dehydrogenase 75330..76241 Mycobacterium bovis BCG str. Tokyo 172 7560998 YP_002643140.1 CDS sdaA NC_012207.1 76266 77651 R L-serine dehydratase complement(76266..77651) Mycobacterium bovis BCG str. Tokyo 172 7560999 YP_002643141.1 CDS glyA NC_012207.1 77648 78925 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(77648..78925) Mycobacterium bovis BCG str. Tokyo 172 7560760 YP_002643142.1 CDS JTY_0073 NC_012207.1 79515 80267 D In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 45 bp insertion (5 copies of VDP repeat) leads to longer products compared to its homologs in Mycobacterium tuberculosis strain H37Rv (250 aa versus 235 aa) and Mycobacterium bovis (250 aa versus 238 aa); maturase 79515..80267 Mycobacterium bovis BCG str. Tokyo 172 7561953 YP_002643143.1 CDS JTY_0074 NC_012207.1 80698 81747 D glutamine-transport transmembrane protein ABC transporter 80698..81747 Mycobacterium bovis BCG str. Tokyo 172 7561000 YP_002643144.1 CDS JTY_0075 NC_012207.1 81750 82742 D In Mycobacterium tuberculosis strain H37Rv, Rv0073 exists as a single gene as in Mycobacterium bovis BCG Pasteur and BCG Tokyo. In Mycobacterium bovis, a frameshift due to a single base deletion (A-*) splits Rv0073 into 2 parts, Mb0074 and Mb0075; glutamine-transport ATP-binding protein ABC transporter 81750..82742 Mycobacterium bovis BCG str. Tokyo 172 7561001 YP_002643145.1 CDS JTY_0076 NC_012207.1 82822 84057 D hypothetical protein 82822..84057 Mycobacterium bovis BCG str. Tokyo 172 7561002 YP_002643146.1 CDS JTY_0077 NC_012207.1 84070 85242 D Differs from Rv0075 and Mb0077 by 1aa, G326D in BCG Pasteur and BCG Tokyo; aminotransferase 84070..85242 Mycobacterium bovis BCG str. Tokyo 172 7561003 YP_002643147.1 CDS JTY_0078 NC_012207.1 85257 85646 R hypothetical protein complement(85257..85646) Mycobacterium bovis BCG str. Tokyo 172 7561004 YP_002643148.1 CDS JTY_0079 NC_012207.1 85710 86540 R oxidoreductase complement(85710..86540) Mycobacterium bovis BCG str. Tokyo 172 7561005 YP_002643149.1 CDS JTY_0080 NC_012207.1 86602 87207 D Differs from Rv0078 by 1aa, V113I in BCG Pasteur and BCG Tokyo; transcriptional regulatory protein 86602..87207 Mycobacterium bovis BCG str. Tokyo 172 7561006 YP_002643150.1 CDS JTY_0081 NC_012207.1 87282 87875 R hypothetical protein complement(87282..87875) Mycobacterium bovis BCG str. Tokyo 172 7561007 YP_002643151.1 CDS JTY_0082 NC_012207.1 87872 88084 R hypothetical protein complement(87872..88084) Mycobacterium bovis BCG str. Tokyo 172 7561008 YP_002643152.1 CDS JTY_0083 NC_012207.1 88278 89099 D hypothetical protein 88278..89099 Mycobacterium bovis BCG str. Tokyo 172 7561009 YP_002643153.1 CDS JTY_0084 NC_012207.1 89096 89554 D Differs from Mb0083 by 1aa, C35R, and from Rv0080 by 2aa, C35R, V60G in BCG Pasteur. Differs from Rv0080 by 1aa, V60G in BCG Tokyo. without qualifier; hypothetical protein 89096..89554 Mycobacterium bovis BCG str. Tokyo 172 7561010 YP_002643154.1 CDS JTY_0085 NC_012207.1 89649 89993 D transcriptional regulatory protein 89649..89993 Mycobacterium bovis BCG str. Tokyo 172 7561011 YP_002643155.1 CDS JTY_0086 NC_012207.1 89998 90477 D Differs from Rv0082 by 1aa, R74Q in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 89998..90477 Mycobacterium bovis BCG str. Tokyo 172 7561012 YP_002643156.1 CDS JTY_0087 NC_012207.1 90474 92402 D In Mycobacterium bovis, a single base transversion (a-t) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (642 aa versus 640 aa). Differs from Mb0086 by 1aa, A177V in BCG Pasteur and BCG Tokyo.; oxidoreductase 90474..92402 Mycobacterium bovis BCG str. Tokyo 172 7561013 YP_002643157.1 CDS hycD NC_012207.1 92402 93352 D formate hydrogenlyase 92402..93352 Mycobacterium bovis BCG str. Tokyo 172 7561014 YP_002643158.1 CDS hycP NC_012207.1 93363 94025 D hydrogenase 93363..94025 Mycobacterium bovis BCG str. Tokyo 172 7563335 YP_002643159.1 CDS hycQ NC_012207.1 94025 95491 D Differs from Rv0086 by 1aa, T118M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrogenase 94025..95491 Mycobacterium bovis BCG str. Tokyo 172 7563337 YP_002643160.1 CDS hycE NC_012207.1 95488 96966 D Differs from Rv0087 by 1aa, I230V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; formate hydrogenase 95488..96966 Mycobacterium bovis BCG str. Tokyo 172 7563338 YP_002643161.1 CDS JTY_0092 NC_012207.1 97001 97675 D hypothetical protein 97001..97675 Mycobacterium bovis BCG str. Tokyo 172 7563336 YP_002643162.1 CDS JTY_0093 NC_012207.1 97832 98425 D methyltransferase/methylase 97832..98425 Mycobacterium bovis BCG str. Tokyo 172 7561015 YP_002643163.1 CDS JTY_0094 NC_012207.1 98554 99324 D hypothetical protein 98554..99324 Mycobacterium bovis BCG str. Tokyo 172 7561016 YP_002643164.1 CDS mtn NC_012207.1 99758 100525 D bifunctional MTA/SAH nucleosidase 99758..100525 Mycobacterium bovis BCG str. Tokyo 172 7561017 YP_002643165.1 CDS ctpA NC_012207.1 100657 102942 D Differs from Rv0092 by 1aa, A3T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cation transporter p-type ATPase A 100657..102942 Mycobacterium bovis BCG str. Tokyo 172 7563567 YP_002643166.1 CDS JTY_0097 NC_012207.1 102889 103737 R Differs from Rv0093c by 1aa, R22C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(102889..103737) Mycobacterium bovis BCG str. Tokyo 172 7563131 YP_002643167.1 CDS JTY_0098 NC_012207.1 103784 104737 R Differs from Rv0094c by 3aa, D256E, W296R, K315E in BCG Pasteur and BCG Tokyo; hypothetical protein complement(103784..104737) Mycobacterium bovis BCG str. Tokyo 172 7561018 YP_002643168.1 CDS JTY_0099 NC_012207.1 104508 105290 R In Mycobacterium tuberculosis strain H37Rv, Rv0095c and Rv1588 exist as separate genes in their respective positions. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 73 bp substitution leads to a single combined gene. Differs from Rv0095c by 5aa, E57D, T70S, V85A, V91G, A92Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(104508..105290) Mycobacterium bovis BCG str. Tokyo 172 7561019 YP_002643169.1 CDS PPE1 NC_012207.1 105399 106790 D Differs from Rv0096 by 1aa, W182R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PPE family protein 105399..106790 Mycobacterium bovis BCG str. Tokyo 172 7561020 YP_002643170.1 CDS JTY_0101 NC_012207.1 106809 107678 D oxidoreductase 106809..107678 Mycobacterium bovis BCG str. Tokyo 172 7562144 YP_002643171.1 CDS JTY_0102 NC_012207.1 107675 108226 D hypothetical protein 107675..108226 Mycobacterium bovis BCG str. Tokyo 172 7561021 YP_002643172.1 CDS fadD10 NC_012207.1 108231 109853 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 108231..109853 Mycobacterium bovis BCG str. Tokyo 172 7561022 YP_002643173.1 CDS JTY_0104 NC_012207.1 109858 110094 D hypothetical protein 109858..110094 Mycobacterium bovis BCG str. Tokyo 172 7562916 YP_002643174.1 CDS nrp NC_012207.1 110076 117614 D peptide synthetase 110076..117614 Mycobacterium bovis BCG str. Tokyo 172 7561023 YP_002643175.1 CDS JTY_0106 NC_012207.1 117789 119774 D integral membrane protein 117789..119774 Mycobacterium bovis BCG str. Tokyo 172 7562471 YP_002643176.1 CDS ctpB NC_012207.1 119990 122248 R Differs from Rv0103c by 1aa, S22L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cation-transporter P-type ATPase B complement(119990..122248) Mycobacterium bovis BCG str. Tokyo 172 7561024 YP_002643177.1 CDS JTY_0108 NC_012207.1 122392 123906 D hypothetical protein 122392..123906 Mycobacterium bovis BCG str. Tokyo 172 7563132 YP_002643178.1 CDS rpmB NC_012207.1 124055 124339 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(124055..124339) Mycobacterium bovis BCG str. Tokyo 172 7561025 YP_002643179.1 CDS JTY_0110 NC_012207.1 124449 125645 D hypothetical protein 124449..125645 Mycobacterium bovis BCG str. Tokyo 172 7560714 YP_002643180.1 CDS ctpI NC_012207.1 125740 130617 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-T) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv differs from Rv0107c by 3aa, V136A, P1247S, S1327A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cation-transporter ATPase I complement(125740..130617) Mycobacterium bovis BCG str. Tokyo 172 7561026 YP_002643181.1 CDS JTY_0112 NC_012207.1 130971 131180 R hypothetical protein complement(130971..131180) Mycobacterium bovis BCG str. Tokyo 172 7563139 YP_002643182.1 CDS PE_PGRS1 NC_012207.1 131459 132949 D Differs from Rv0109 by 1aa, G346R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PE-PGRS family protein 131459..132949 Mycobacterium bovis BCG str. Tokyo 172 7561027 YP_002643183.1 CDS JTY_0114 NC_012207.1 133097 133846 D integral membrane protein 133097..133846 Mycobacterium bovis BCG str. Tokyo 172 7561748 YP_002643184.1 CDS JTY_0115 NC_012207.1 134027 136084 D transmembrane acyltransferase 134027..136084 Mycobacterium bovis BCG str. Tokyo 172 7561028 YP_002643185.1 CDS gca NC_012207.1 136366 137322 D gdp-mannose 4,6-dehydratase 136366..137322 Mycobacterium bovis BCG str. Tokyo 172 7561029 YP_002643186.1 CDS gmhA NC_012207.1 137396 137986 D catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 137396..137986 Mycobacterium bovis BCG str. Tokyo 172 7561906 YP_002643187.1 CDS JTY_0118 NC_012207.1 138018 138590 D Differs from Rv0114 by 1aa, R121G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; dehydratase 138018..138590 Mycobacterium bovis BCG str. Tokyo 172 7563270 YP_002643188.1 CDS JTY_0119 NC_012207.1 138590 139657 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-c) equivalent to Mycobacterium tuberculosis H37Rv position 139559, leads to shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. In addition, in Mycobacterium bovis, a single base insertion, at position equivalent to 138823, leads to a different NH2 part; sugar kinase 138590..139657 Mycobacterium bovis BCG str. Tokyo 172 7561030 YP_002643189.1 CDS JTY_0120 NC_012207.1 140345 141100 R hypothetical protein complement(140345..141100) Mycobacterium bovis BCG str. Tokyo 172 7561031 YP_002643190.1 CDS oxyS NC_012207.1 141278 142222 D oxidative stress response regulatory protein 141278..142222 Mycobacterium bovis BCG str. Tokyo 172 7561032 YP_002643191.1 CDS oxcA NC_012207.1 142206 143954 R catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase complement(142206..143954) Mycobacterium bovis BCG str. Tokyo 172 7562506 YP_002643192.1 CDS fadD7 NC_012207.1 144127 145704 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 144127..145704 Mycobacterium bovis BCG str. Tokyo 172 7562505 YP_002643193.1 CDS fusA2b NC_012207.1 145705 147849 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(145705..147849) Mycobacterium bovis BCG str. Tokyo 172 7563355 YP_002643194.1 CDS JTY_0125 NC_012207.1 147985 148419 R hypothetical protein complement(147985..148419) Mycobacterium bovis BCG str. Tokyo 172 7561889 YP_002643195.1 CDS JTY_0126 NC_012207.1 148568 148936 D hypothetical protein 148568..148936 Mycobacterium bovis BCG str. Tokyo 172 7561033 YP_002643196.1 CDS JTY_0127 NC_012207.1 148933 149301 D hypothetical protein 148933..149301 Mycobacterium bovis BCG str. Tokyo 172 7561034 YP_002643197.1 CDS PE_PGRS2 NC_012207.1 149610 151226 D In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 180 bp insertion leads to a longer product in the 3' direction compared to its homolog in Mycobacterium tuberculosis strain H37Rv (538 aa versus 487 aa); PE-PGRS family protein 149610..151226 Mycobacterium bovis BCG str. Tokyo 172 7561035 YP_002643198.1 CDS pepA NC_012207.1 151378 152445 D serine protease 151378..152445 Mycobacterium bovis BCG str. Tokyo 172 7561759 YP_002643199.1 CDS treS NC_012207.1 152554 154359 D trehalose synthase 152554..154359 Mycobacterium bovis BCG str. Tokyo 172 7561741 YP_002643200.1 CDS JTY_0131 NC_012207.1 154462 155829 D Differs from Rv0127 by 1aa, P18S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 154462..155829 Mycobacterium bovis BCG str. Tokyo 172 7561868 YP_002643201.1 CDS JTY_0132 NC_012207.1 155897 156676 D transmembrane protein 155897..156676 Mycobacterium bovis BCG str. Tokyo 172 7561036 YP_002643202.1 CDS fbpC NC_012207.1 156808 157830 R antigen 85-C complement(156808..157830) Mycobacterium bovis BCG str. Tokyo 172 7561037 YP_002643203.1 CDS JTY_0134 NC_012207.1 158077 158532 D hypothetical protein 158077..158532 Mycobacterium bovis BCG str. Tokyo 172 7563402 YP_002643204.1 CDS fadE1 NC_012207.1 158545 159888 R acyl-CoA dehydrogenase complement(158545..159888) Mycobacterium bovis BCG str. Tokyo 172 7561038 YP_002643205.1 CDS fgd2 NC_012207.1 159930 161012 R Differs from Mb0137c by 1aa, E147K in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; F420-dependent glucose-6-phosphate dehydrogenase complement(159930..161012) Mycobacterium bovis BCG str. Tokyo 172 7563358 YP_002643206.1 CDS JTY_0137 NC_012207.1 161099 161581 D In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis AF2122/97, codon 161 is TAC and in Mycobacterium bovis BCG Pasteur and BCG Tokyo, TAA; acetyltransferase 161099..161581 Mycobacterium bovis BCG str. Tokyo 172 7563413 YP_002643207.1 CDS JTY_0141 NC_012207.1 162874 163479 R transcriptional regulatory protein complement(162874..163479) Mycobacterium bovis BCG str. Tokyo 172 7564171 YP_002643208.1 CDS cyp138 NC_012207.1 163596 164921 D cytochrome p450 138 163596..164921 Mycobacterium bovis BCG str. Tokyo 172 7564172 YP_002643209.1 CDS msrA NC_012207.1 164942 165490 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A complement(164942..165490) Mycobacterium bovis BCG str. Tokyo 172 7563164 YP_002643210.1 CDS JTY_0144 NC_012207.1 165553 166056 D Differs from Mb0143 by 1aa, D96G in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 165553..166056 Mycobacterium bovis BCG str. Tokyo 172 7563565 YP_002643211.1 CDS JTY_0145 NC_012207.1 166057 167079 D Differs from Mb0144 by 1aa, R227H in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 166057..167079 Mycobacterium bovis BCG str. Tokyo 172 7564173 YP_002643212.1 CDS JTY_0146 NC_012207.1 167140 167520 D hypothetical protein 167140..167520 Mycobacterium bovis BCG str. Tokyo 172 7564174 YP_002643213.1 CDS JTY_0147 NC_012207.1 167501 167911 R hypothetical protein complement(167501..167911) Mycobacterium bovis BCG str. Tokyo 172 7564175 YP_002643214.1 CDS JTY_0148 NC_012207.1 167941 168867 D hypothetical protein 167941..168867 Mycobacterium bovis BCG str. Tokyo 172 7564176 YP_002643215.1 CDS JTY_0149 NC_012207.1 168934 170412 R Differs from Rv0143c by 1aa, L34F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein complement(168934..170412) Mycobacterium bovis BCG str. Tokyo 172 7564177 YP_002643216.1 CDS JTY_0150 NC_012207.1 170514 171356 D possibly TetR-family; transcriptional regulatory protein 170514..171356 Mycobacterium bovis BCG str. Tokyo 172 7564178 YP_002643217.1 CDS JTY_0151 NC_012207.1 171445 172398 D hypothetical protein 171445..172398 Mycobacterium bovis BCG str. Tokyo 172 7564179 YP_002643218.1 CDS JTY_0152 NC_012207.1 172441 173373 D hypothetical protein 172441..173373 Mycobacterium bovis BCG str. Tokyo 172 7564180 YP_002643219.1 CDS JTY_0153 NC_012207.1 173468 174988 D aldehyde dehydrogenase 173468..174988 Mycobacterium bovis BCG str. Tokyo 172 7564181 YP_002643220.1 CDS JTY_0154 NC_012207.1 175063 175923 D short-chain type dehydrogenase/reductase 175063..175923 Mycobacterium bovis BCG str. Tokyo 172 7564182 YP_002643221.1 CDS JTY_0155 NC_012207.1 175930 176898 D quinone oxidoreductase 175930..176898 Mycobacterium bovis BCG str. Tokyo 172 7564183 YP_002643222.1 CDS JTY_0156 NC_012207.1 176895 177182 R hypothetical protein complement(176895..177182) Mycobacterium bovis BCG str. Tokyo 172 7564184 YP_002643223.1 CDS PE1 NC_012207.1 177773 179539 R Differs from Rv0151c by 1aa, R26G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PE family protein complement(177773..179539) Mycobacterium bovis BCG str. Tokyo 172 7564185 YP_002643224.1 CDS PE2 NC_012207.1 179549 181126 R PE family protein complement(179549..181126) Mycobacterium bovis BCG str. Tokyo 172 7561709 YP_002643225.1 CDS ptbB NC_012207.1 181385 182215 R Differs from Rv0153c by 1aa, G105D in BCG Pasteur and BCG Tokyo; phosphotyrosine protein phosphatase complement(181385..182215) Mycobacterium bovis BCG str. Tokyo 172 7561720 YP_002643226.1 CDS fadE2 NC_012207.1 182217 183428 R acyl-CoA dehydrogenase complement(182217..183428) Mycobacterium bovis BCG str. Tokyo 172 7560850 YP_002643227.1 CDS pntAa NC_012207.1 183852 184952 D NAD(P) transhydrogenase subunit alpha 183852..184952 Mycobacterium bovis BCG str. Tokyo 172 7563368 YP_002643228.1 CDS pntAb NC_012207.1 184953 185285 D Differs from Rv0156 by 1aa, C2Y in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; NAD(P) transhydrogenase subunit alpha 184953..185285 Mycobacterium bovis BCG str. Tokyo 172 7562136 YP_002643229.1 CDS pntB NC_012207.1 185282 186709 D NAD(P) transhydrogenase subunit beta 185282..186709 Mycobacterium bovis BCG str. Tokyo 172 7562137 YP_002643230.1 CDS JTY_0164 NC_012207.1 187015 187659 D possibly TetR-family; transcriptional regulatory protein 187015..187659 Mycobacterium bovis BCG str. Tokyo 172 7562138 YP_002643231.1 CDS PE3 NC_012207.1 187663 189069 R Differs from Rv0159c by 1aa, T255P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PE family protein complement(187663..189069) Mycobacterium bovis BCG str. Tokyo 172 7564186 YP_002643232.1 CDS PE4 NC_012207.1 189161 190669 R Differs from Rv0160c by 2aa, T116A, T211A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PE family protein complement(189161..190669) Mycobacterium bovis BCG str. Tokyo 172 7561730 YP_002643233.1 CDS JTY_0167 NC_012207.1 190837 192186 D oxidoreductase 190837..192186 Mycobacterium bovis BCG str. Tokyo 172 7561735 YP_002643234.1 CDS adhE1 NC_012207.1 192214 193365 R Differs from Rv0162c and Mb0167c by 1aa, R41H in BCG Pasteur and BCG Tokyo; zinc-type alcohol dehydrogenase e subunit complement(192214..193365) Mycobacterium bovis BCG str. Tokyo 172 7564187 YP_002643235.1 CDS JTY_0169 NC_012207.1 193347 193802 D hypothetical protein 193347..193802 Mycobacterium bovis BCG str. Tokyo 172 7563945 YP_002643236.1 CDS TB18.5 NC_012207.1 193856 194341 D hypothetical protein 193856..194341 Mycobacterium bovis BCG str. Tokyo 172 7564188 YP_002643237.1 CDS JTY_0171 NC_012207.1 194355 195170 R In Mycobacterium tuberculosis strain H37Rv, Rv0165c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a 2bp insertion (*-CC) leads to a product with a different COOH terminus; probably GntR-family; transcriptional regulatory protein complement(194355..195170) Mycobacterium bovis BCG str. Tokyo 172 7561830 YP_002643238.1 CDS fadD5 NC_012207.1 195225 196889 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 195225..196889 Mycobacterium bovis BCG str. Tokyo 172 7564189 YP_002643239.1 CDS yrbE1A NC_012207.1 197093 197890 D hypothetical protein 197093..197890 Mycobacterium bovis BCG str. Tokyo 172 7563353 YP_002643240.1 CDS yrbE1B NC_012207.1 197892 198761 D hypothetical protein 197892..198761 Mycobacterium bovis BCG str. Tokyo 172 7561706 YP_002643241.1 CDS mce1A NC_012207.1 198766 200130 D Differs from Rv0169 by 2aa, A313S, S359P. Differs from Rv0169 by 2aa, A313S, S359P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; MCE-family protein 198766..200130 Mycobacterium bovis BCG str. Tokyo 172 7561451 YP_002643242.1 CDS mce1B NC_012207.1 200127 201167 D Differs from Rv0170 by 1aa, T179I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; MCE-family protein 200127..201167 Mycobacterium bovis BCG str. Tokyo 172 7564432 YP_002643243.1 CDS mce1C NC_012207.1 201164 202711 D Differs from Rv0171 by 1aa, D212E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; MCE-family protein 201164..202711 Mycobacterium bovis BCG str. Tokyo 172 7564433 YP_002643244.1 CDS mce1D NC_012207.1 202708 204300 D MCE-family protein 202708..204300 Mycobacterium bovis BCG str. Tokyo 172 7564434 YP_002643245.1 CDS lprK NC_012207.1 204297 205469 D MCE-family lipoprotein mce1E 204297..205469 Mycobacterium bovis BCG str. Tokyo 172 7564435 YP_002643246.1 CDS mce1F NC_012207.1 205463 207010 D Differs from Rv0174 by 1aa, P370L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; MCE-family protein 205463..207010 Mycobacterium bovis BCG str. Tokyo 172 7560529 YP_002643247.1 CDS JTY_0181 NC_012207.1 207046 207687 D MCE associated membrane protein 207046..207687 Mycobacterium bovis BCG str. Tokyo 172 7564436 YP_002643248.1 CDS JTY_0182 NC_012207.1 207684 208652 D Differs from Mb0182 by 1aa, S285N, and from Rv0176 by 3aa, S285N, S290Q, A291S in BCG Pasteur and BCG Tokyo; MCE associated transmembrane protein 207684..208652 Mycobacterium bovis BCG str. Tokyo 172 7564190 YP_002643249.1 CDS JTY_0183 NC_012207.1 208649 209203 D MCE associated protein 208649..209203 Mycobacterium bovis BCG str. Tokyo 172 7564191 YP_002643250.1 CDS JTY_0184 NC_012207.1 209170 209904 D MCE associated membrane protein 209170..209904 Mycobacterium bovis BCG str. Tokyo 172 7564192 YP_002643251.1 CDS lprO NC_012207.1 209935 211044 R Differs from Rv0179c by 1aa, H124R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein complement(209935..211044) Mycobacterium bovis BCG str. Tokyo 172 7564193 YP_002643252.1 CDS JTY_0186 NC_012207.1 211124 212482 R transmembrane protein complement(211124..212482) Mycobacterium bovis BCG str. Tokyo 172 7560532 YP_002643253.1 CDS JTY_0187 NC_012207.1 212509 213243 R hypothetical protein complement(212509..213243) Mycobacterium bovis BCG str. Tokyo 172 7564194 YP_002643254.1 CDS sigG NC_012207.1 213260 214372 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; RNA polymerase factor sigma-70 complement(213260..214372) Mycobacterium bovis BCG str. Tokyo 172 7564195 YP_002643255.1 CDS JTY_0189 NC_012207.1 214320 215159 D lysophospholipase 214320..215159 Mycobacterium bovis BCG str. Tokyo 172 7561791 YP_002643256.1 CDS JTY_0190 NC_012207.1 215201 215950 D hypothetical protein 215201..215950 Mycobacterium bovis BCG str. Tokyo 172 7564196 YP_002643257.1 CDS JTY_0191 NC_012207.1 215947 216456 D hypothetical protein 215947..216456 Mycobacterium bovis BCG str. Tokyo 172 7564197 YP_002643258.1 CDS bglS NC_012207.1 216501 218576 D Differs from Mb0192 by 1aa, S504I, and from Rv0186 by 2aa, S504I, R532P in BCG Pasteur and BCG Tokyo; beta-glucosidase 216501..218576 Mycobacterium bovis BCG str. Tokyo 172 7564198 YP_002643259.1 CDS JTY_0193 NC_012207.1 218937 219599 D Differs from Rv0187 and Mb0193 by 1aa, V147A in BCG Pasteur and BCG Tokyo; O-methyltransferase 218937..219599 Mycobacterium bovis BCG str. Tokyo 172 7562065 YP_002643260.1 CDS JTY_0194 NC_012207.1 219718 220149 D transmembrane protein 219718..220149 Mycobacterium bovis BCG str. Tokyo 172 7564199 YP_002643261.1 CDS ilvD NC_012207.1 220228 221955 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(220228..221955) Mycobacterium bovis BCG str. Tokyo 172 7564200 YP_002643262.1 CDS JTY_0196 NC_012207.1 222103 222393 D hypothetical protein 222103..222393 Mycobacterium bovis BCG str. Tokyo 172 7562779 YP_002643263.1 CDS JTY_0197 NC_012207.1 222521 223762 D integral membrane protein 222521..223762 Mycobacterium bovis BCG str. Tokyo 172 7564201 YP_002643264.1 CDS JTY_0198 NC_012207.1 223839 224897 D In Mycobacterium tuberculosis strain H37Rv, Rv0192 and Rv0192A exist as 2 genes with an overlap region. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-g) leads to a single product. Differs from Mb0198 by 1aa, A279V and from Rv0192 by 2aa, P113S, A279V in BCG Pasteur and BCG Tokyo; hypothetical protein 223839..224897 Mycobacterium bovis BCG str. Tokyo 172 7564202 YP_002643265.1 CDS JTY_0199 NC_012207.1 224957 226804 R Differs from Rv0193c and Mb0199c by 1aa, E417K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(224957..226804) Mycobacterium bovis BCG str. Tokyo 172 7564203 YP_002643266.1 CDS JTY_0200 NC_012207.1 227111 230695 D Differs from Mb0200 by 1aa, I49V, and from Rv0194 by 2aa, T74M, M223T in BCG Pasteur and BCG Tokyo; drugs-transport transmembrane ATP-binding protein ABC transporter 227111..230695 Mycobacterium bovis BCG str. Tokyo 172 7564204 YP_002643267.1 CDS JTY_0201 NC_012207.1 231133 231768 D probably LuxR-family; two component transcriptional regulatory protein 231133..231768 Mycobacterium bovis BCG str. Tokyo 172 7564205 YP_002643268.1 CDS JTY_0202 NC_012207.1 231881 232465 D transcriptional regulatory protein 231881..232465 Mycobacterium bovis BCG str. Tokyo 172 7564206 YP_002643269.1 CDS JTY_0203 NC_012207.1 232465 234711 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transversion (T-G) introduces a stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (748 aa versus 762 aa). Differs from Rv0197 by 1aa, S378R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 232465..234711 Mycobacterium bovis BCG str. Tokyo 172 7564207 YP_002643270.1 CDS JTY_0204 NC_012207.1 234752 236743 R zinc metalloprotease complement(234752..236743) Mycobacterium bovis BCG str. Tokyo 172 7564208 YP_002643271.1 CDS JTY_0205 NC_012207.1 236786 237445 D hypothetical protein 236786..237445 Mycobacterium bovis BCG str. Tokyo 172 7564209 YP_002643272.1 CDS JTY_0206 NC_012207.1 237442 238131 D transmembrane protein 237442..238131 Mycobacterium bovis BCG str. Tokyo 172 7564210 YP_002643273.1 CDS JTY_0207 NC_012207.1 238128 238631 R hypothetical protein complement(238128..238631) Mycobacterium bovis BCG str. Tokyo 172 7564211 YP_002643274.1 CDS mmpL11 NC_012207.1 238628 241528 R transmembrane transport protein complement(238628..241528) Mycobacterium bovis BCG str. Tokyo 172 7564212 YP_002643275.1 CDS JTY_0209 NC_012207.1 241750 242160 D Differs from Rv0203 and Mb0209 by 1aa, T88K in BCG Pasteur and BCG Tokyo; hypothetical protein 241750..242160 Mycobacterium bovis BCG str. Tokyo 172 7564481 YP_002643276.1 CDS JTY_0210 NC_012207.1 242212 243495 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, the presence of a more likely start codon leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (427 aa versus 412 aa). Differs from Rv0204c by 1aa, L321V in BCG Pasteur and BCG Tokyo; transmembrane protein complement(242212..243495) Mycobacterium bovis BCG str. Tokyo 172 7564213 YP_002643277.1 CDS JTY_0211 NC_012207.1 243620 244723 D Differs from Rv0205 by 1aa, R72H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; transmembrane protein 243620..244723 Mycobacterium bovis BCG str. Tokyo 172 7564214 YP_002643278.1 CDS mmpL3 NC_012207.1 244720 247554 R Differs from Rv0206c by 2aa, I384F, E466D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; conserved transmembrane transport protein complement(244720..247554) Mycobacterium bovis BCG str. Tokyo 172 7564215 YP_002643279.1 CDS JTY_0213 NC_012207.1 247620 248348 R hypothetical protein complement(247620..248348) Mycobacterium bovis BCG str. Tokyo 172 7564488 YP_002643280.1 CDS trmB NC_012207.1 248351 249142 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(248351..249142) Mycobacterium bovis BCG str. Tokyo 172 7564216 YP_002643281.1 CDS JTY_0215 NC_012207.1 249274 250359 D Differs from Rv0209 by 1aa, A162V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 249274..250359 Mycobacterium bovis BCG str. Tokyo 172 7564217 YP_002643282.1 CDS JTY_0216 NC_012207.1 250356 251834 D Differs from Rv0210 by 1aa, T486A in Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 250356..251834 Mycobacterium bovis BCG str. Tokyo 172 7564218 YP_002643283.1 CDS pckA NC_012207.1 252018 253838 D catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP; phosphoenolpyruvate carboxykinase 252018..253838 Mycobacterium bovis BCG str. Tokyo 172 7564219 YP_002643284.1 CDS nadR NC_012207.1 253905 254876 R probably AsnC-family; transcriptional regulatory protein complement(253905..254876) Mycobacterium bovis BCG str. Tokyo 172 7562523 YP_002643285.1 CDS JTY_0219 NC_012207.1 254873 256186 R methyltransferase complement(254873..256186) Mycobacterium bovis BCG str. Tokyo 172 7563590 YP_002643286.1 CDS fadD4 NC_012207.1 256300 257913 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 256300..257913 Mycobacterium bovis BCG str. Tokyo 172 7564220 YP_002643287.1 CDS fadE3 NC_012207.1 257955 259121 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 29 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (388 aa versus 357 aa). Differs from Mb0221c by 1aa, S361A in BCG Pasteur and BCG Tokyo; acyl-CoA dehydrogenase complement(257955..259121) Mycobacterium bovis BCG str. Tokyo 172 7563352 YP_002643288.1 CDS JTY_0222 NC_012207.1 259178 260191 D hypothetical protein 259178..260191 Mycobacterium bovis BCG str. Tokyo 172 7563379 YP_002643289.1 CDS lipW NC_012207.1 260188 261096 R Differs from Rv0217c by 1aa T184P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; esterase complement(260188..261096) Mycobacterium bovis BCG str. Tokyo 172 7564221 YP_002643290.1 CDS JTY_0224 NC_012207.1 261189 262517 D Differs from Rv0218 by 2aa, R316C, N413D; transmembrane protein 261189..262517 Mycobacterium bovis BCG str. Tokyo 172 7562849 YP_002643291.1 CDS JTY_0225 NC_012207.1 262519 263067 D transmembrane protein 262519..263067 Mycobacterium bovis BCG str. Tokyo 172 7564222 YP_002643292.1 CDS lipC NC_012207.1 263077 264318 D esterase 263077..264318 Mycobacterium bovis BCG str. Tokyo 172 7564223 YP_002643293.1 CDS JTY_0227 NC_012207.1 264332 265105 D In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, and BCG Tokyo, RD10, a 1902 bp deletion leads to a shorter product with a different COOH part, compared to its homolog in Mycobacterium tuberculosis strain H37Rv (257 aa versus 469 aa). It also leads to the deletion of the next protein, echA1 (Rv0222) in BCG Pasteur and BCG Tokyo; hypothetical protein 264332..265105 Mycobacterium bovis BCG str. Tokyo 172 7562831 YP_002643294.1 CDS JTY_0228 NC_012207.1 264971 265780 R In mycobacterium bovis strain AF2122/97, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, RD10, a 1902 bp deletion, compared to Mycobacterium tuberculosis H37Rv, truncates Rv0221c and Rv0223c and removes Rv0222c. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base deletion at position equivalent to Mycobacterium tuberculosis H37Rv 267419-267419 (*-C) splits gene into two parts compared to its homologs in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis AF2122/97 (116 aa and 269 aa, versus 487 aa and 385 aa, respectively. Also has same 1 bp insertion, as Mycobacterium bovis AF2122/97, at position equivalent to Mycobacterium tuberculosis H37Rv base 266743. Deletion in Mycobacterium bovis, bovis BCG Pasteur, and BCG Tokyo of region RD10 leads to a different COOH part compared to Mycobacterium tuberculosis strain H37Rv. Maybe pseudogene.; aldehyde dehydrogenase complement(264971..265780) Mycobacterium bovis BCG str. Tokyo 172 7564224 YP_002643295.1 CDS JTY_0229 NC_012207.1 265777 266127 R In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base deletion at position equivalent to Mycobacterium tuberculosis H37Rv2 267419-267419 (*-C) splits gene into two parts compared to its homologs in Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis AF2122/97 (116 aa and 269 aa, versus 487 aa and 385 aa, respectively. Also has same 1 bp insertion, as Mycobacterium bovis AF2122/97, at position equivalent to Mycobacterium tuberculosis H37Rv2 base 266743. May be pseudogene; aldehyde dehydrogenase complement(265777..266127) Mycobacterium bovis BCG str. Tokyo 172 7564225 YP_002643296.1 CDS JTY_0230 NC_012207.1 266226 266990 R Differs from Rv0224c by 1aa, L117F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methyltransferase complement(266226..266990) Mycobacterium bovis BCG str. Tokyo 172 7564226 YP_002643297.1 CDS JTY_0231 NC_012207.1 267026 268180 D hypothetical protein 267026..268180 Mycobacterium bovis BCG str. Tokyo 172 7564227 YP_002643298.1 CDS JTY_0232 NC_012207.1 268197 269927 R transmembrane protein complement(268197..269927) Mycobacterium bovis BCG str. Tokyo 172 7564228 YP_002643299.1 CDS JTY_0233 NC_012207.1 269937 271202 R Differs from Rv0227c by 1aa, R29S, and from Mb0232c by 1aa, S392N in BCG Pasteur and BCG Tokyo; hypothetical protein complement(269937..271202) Mycobacterium bovis BCG str. Tokyo 172 7564229 YP_002643300.1 CDS JTY_0234 NC_012207.1 271418 272641 D integral membrane acyltransferase 271418..272641 Mycobacterium bovis BCG str. Tokyo 172 7564230 YP_002643301.1 CDS JTY_0235 NC_012207.1 272669 273349 R hypothetical protein complement(272669..273349) Mycobacterium bovis BCG str. Tokyo 172 7564231 YP_002643302.1 CDS php NC_012207.1 273346 274326 R Differs from Rv0230c by 1aa, E199D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; phosphotriesterase complement(273346..274326) Mycobacterium bovis BCG str. Tokyo 172 7564232 YP_002643303.1 CDS fadE4 NC_012207.1 274421 276127 D acyl-CoA dehydrogenase 274421..276127 Mycobacterium bovis BCG str. Tokyo 172 7562419 YP_002643304.1 CDS JTY_0238 NC_012207.1 276262 276951 D probably TetR/AcrR-family; transcriptional regulatory protein 276262..276951 Mycobacterium bovis BCG str. Tokyo 172 7563387 YP_002643305.1 CDS nrdB NC_012207.1 276948 277892 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit beta 276948..277892 Mycobacterium bovis BCG str. Tokyo 172 7564233 YP_002643306.1 CDS gabD1 NC_012207.1 277968 279503 R NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinic semialdehyde dehydrogenase complement(277968..279503) Mycobacterium bovis BCG str. Tokyo 172 7562464 YP_002643307.1 CDS JTY_0241 NC_012207.1 279529 280977 R transmembrane protein complement(279529..280977) Mycobacterium bovis BCG str. Tokyo 172 7561891 YP_002643308.1 CDS JTY_0242 NC_012207.1 281012 285214 R Differs from Rv0236c by 3aa, V412M, A990T, G1080S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein complement(281012..285214) Mycobacterium bovis BCG str. Tokyo 172 7564234 YP_002643309.1 CDS JTY_0243 NC_012207.1 285261 285434 R hypothetical protein complement(285261..285434) Mycobacterium bovis BCG str. Tokyo 172 7564235 YP_002643310.1 CDS lpqI NC_012207.1 285549 286715 D Differs from Rv0237 by 1aa, L129V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 285549..286715 Mycobacterium bovis BCG str. Tokyo 172 7564236 YP_002643311.1 CDS JTY_0245 NC_012207.1 286791 287405 D probably TetR-family; transcriptional regulatory protein 286791..287405 Mycobacterium bovis BCG str. Tokyo 172 7560501 YP_002643312.1 CDS JTY_0246 NC_012207.1 287467 287700 D hypothetical protein 287467..287700 Mycobacterium bovis BCG str. Tokyo 172 7564237 YP_002643313.1 CDS JTY_0247 NC_012207.1 287708 288145 D Differs from Rv0240 by 1aa, S31A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 287708..288145 Mycobacterium bovis BCG str. Tokyo 172 7564238 YP_002643314.1 CDS JTY_0248 NC_012207.1 288175 289017 R hypothetical protein complement(288175..289017) Mycobacterium bovis BCG str. Tokyo 172 7564239 YP_002643315.1 CDS fabG NC_012207.1 289028 290392 R Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(289028..290392) Mycobacterium bovis BCG str. Tokyo 172 7564240 YP_002643316.1 CDS fadA2 NC_012207.1 290534 291856 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 290534..291856 Mycobacterium bovis BCG str. Tokyo 172 7562902 YP_002643317.1 CDS fadE5 NC_012207.1 292162 293997 R Differs from Mb0250c by 1aa, N503D and from Rv0244c by 3aa, R394K, A479E, N503D in BCG Pasteur and BCG Tokyo; acyl-CoA dehydrogenase complement(292162..293997) Mycobacterium bovis BCG str. Tokyo 172 7562905 YP_002643318.1 CDS JTY_0252 NC_012207.1 294369 294857 D oxidoreductase 294369..294857 Mycobacterium bovis BCG str. Tokyo 172 7563388 YP_002643319.1 CDS JTY_0253 NC_012207.1 295173 296483 D Differs from Mb0252 by 1aa, A129V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein 295173..296483 Mycobacterium bovis BCG str. Tokyo 172 7564241 YP_002643320.1 CDS JTY_0254 NC_012207.1 296480 297226 R catalyzes the fumarate and succinate interconversion; fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source; fumarate reductase iron-sulfur subunit complement(296480..297226) Mycobacterium bovis BCG str. Tokyo 172 7564242 YP_002643321.1 CDS sdhA NC_012207.1 297227 299167 R part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit complement(297227..299167) Mycobacterium bovis BCG str. Tokyo 172 7564243 YP_002643322.1 CDS JTY_0256 NC_012207.1 299198 300019 R succinate dehydrogenase membrane anchor subunit complement(299198..300019) Mycobacterium bovis BCG str. Tokyo 172 7560761 YP_002643323.1 CDS JTY_0257 NC_012207.1 300099 300392 R hypothetical protein complement(300099..300392) Mycobacterium bovis BCG str. Tokyo 172 7564244 YP_002643324.1 CDS hsp NC_012207.1 300537 301016 R heat shock protein complement(300537..301016) Mycobacterium bovis BCG str. Tokyo 172 7564245 YP_002643325.1 CDS nirB NC_012207.1 301230 303791 D fad flavoprotein; nitrite reductase [NAD(P)H] large subunit 301230..303791 Mycobacterium bovis BCG str. Tokyo 172 7563328 YP_002643326.1 CDS nirD NC_012207.1 303817 304173 D nitrite reductase [NAD(P)H] small subunit 303817..304173 Mycobacterium bovis BCG str. Tokyo 172 7562462 YP_002643327.1 CDS cobU NC_012207.1 304189 304713 R cobinamide kinase, cobinamide phosphate guanylyltransferase; cobalamin biosynthesis protein complement(304189..304713) Mycobacterium bovis BCG str. Tokyo 172 7562463 YP_002643328.1 CDS cobQ1 NC_012207.1 304738 306222 R catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation; cobyric acid synthase complement(304738..306222) Mycobacterium bovis BCG str. Tokyo 172 7563119 YP_002643329.1 CDS PPE2 NC_012207.1 306241 307911 R PPE family protein complement(306241..307911) Mycobacterium bovis BCG str. Tokyo 172 7563115 YP_002643330.1 CDS JTY_0264 NC_012207.1 308219 308437 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (C-T) leads to a truncated product in the 5' direction compared to Mycobacterium tuberculosis strain H37Rv (72 aa versus 124 aa); hypothetical protein 308219..308437 Mycobacterium bovis BCG str. Tokyo 172 7562156 YP_002643331.1 CDS JTY_0265 NC_012207.1 308658 309113 R hypothetical protein complement(308658..309113) Mycobacterium bovis BCG str. Tokyo 172 7564246 YP_002643332.1 CDS JTY_0266 NC_012207.1 309138 309881 R Differs from Rv0259c by 1aa, V182A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(309138..309881) Mycobacterium bovis BCG str. Tokyo 172 7564247 YP_002643333.1 CDS JTY_0267 NC_012207.1 309878 311023 R catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; bifunctional uroporphyrinogen-III synthetase/response regulator domain protein complement(309878..311023) Mycobacterium bovis BCG str. Tokyo 172 7564248 YP_002643334.1 CDS narK3 NC_012207.1 311123 312532 R integral membrane nitrite extrusion protein complement(311123..312532) Mycobacterium bovis BCG str. Tokyo 172 7564249 YP_002643335.1 CDS aac NC_012207.1 312673 313218 R aminoglycoside 2'-N-acetyltransferase complement(312673..313218) Mycobacterium bovis BCG str. Tokyo 172 7562451 YP_002643336.1 CDS JTY_0270 NC_012207.1 313228 314130 R hypothetical protein complement(313228..314130) Mycobacterium bovis BCG str. Tokyo 172 7564327 YP_002643337.1 CDS JTY_0271 NC_012207.1 314147 314779 R hypothetical protein complement(314147..314779) Mycobacterium bovis BCG str. Tokyo 172 7564250 YP_002643338.1 CDS JTY_0272 NC_012207.1 314875 315867 R Differs from Rv0265c and Mb0271c by 1aa, C313Y in BCG Pasteur and BCG Tokyo; periplasmic iron-transport lipoprotein complement(314875..315867) Mycobacterium bovis BCG str. Tokyo 172 7563020 YP_002643339.1 CDS oplA NC_012207.1 315889 319518 R 5-oxoprolinase complement(315889..319518) Mycobacterium bovis BCG str. Tokyo 172 7563021 YP_002643340.1 CDS narU NC_012207.1 319695 321086 D integral membrane nitrite extrusion protein 319695..321086 Mycobacterium bovis BCG str. Tokyo 172 7562496 YP_002643341.1 CDS JTY_0275 NC_012207.1 321128 321637 R hypothetical protein complement(321128..321637) Mycobacterium bovis BCG str. Tokyo 172 7562453 YP_002643342.1 CDS JTY_0276 NC_012207.1 321702 322895 R hypothetical protein complement(321702..322895) Mycobacterium bovis BCG str. Tokyo 172 7563022 YP_002643343.1 CDS fadD2 NC_012207.1 322931 324613 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 322931..324613 Mycobacterium bovis BCG str. Tokyo 172 7563023 YP_002643344.1 CDS fadE6 NC_012207.1 324630 326825 R acyl-CoA dehydrogenase complement(324630..326825) Mycobacterium bovis BCG str. Tokyo 172 7562926 YP_002643345.1 CDS JTY_0279 NC_012207.1 326939 328072 R Differs from Mb0278c by 1aa, P164L in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(326939..328072) Mycobacterium bovis BCG str. Tokyo 172 7563389 YP_002643346.1 CDS JTY_0280 NC_012207.1 328069 328689 R transcriptional regulatory protein complement(328069..328689) Mycobacterium bovis BCG str. Tokyo 172 7563024 YP_002643347.1 CDS JTY_0281 NC_012207.1 328786 329367 D hypothetical protein 328786..329367 Mycobacterium bovis BCG str. Tokyo 172 7563025 YP_002643348.1 CDS JTY_0282 NC_012207.1 329297 330022 R Differs from Rv0275c by 1aa, L24S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; possibly TetR-family; transcriptional regulatory protein complement(329297..330022) Mycobacterium bovis BCG str. Tokyo 172 7563026 YP_002643349.1 CDS JTY_0283 NC_012207.1 330112 331032 D hypothetical protein 330112..331032 Mycobacterium bovis BCG str. Tokyo 172 7563027 YP_002643350.1 CDS JTY_0284 NC_012207.1 331072 331500 R hypothetical protein complement(331072..331500) Mycobacterium bovis BCG str. Tokyo 172 7563028 YP_002643351.1 CDS JTY_0285 NC_012207.1 331524 331781 R Differs by 1 aa, Q24* from Rv0227A and Mb0351A in BCG Pasteur and BCG Tokyo; antitoxin complement(331524..331781) Mycobacterium bovis BCG str. Tokyo 172 7563029 YP_002643352.1 CDS PE_PGRS3a NC_012207.1 331866 334616 R In Mycobacterium tuberculosis strain H37Rv, PE_PGRS3 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovs BCG Pasteur and BCG Tokyo, a large insertion leads to an extra copy of PE_PGRS3. Also, a frameshift due to single base deletion (T-*), splits this extra copy of PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b. Also differs from Mb0285c by an insertion of 144bp.; PE-PGRS family protein complement(331866..334616) Mycobacterium bovis BCG str. Tokyo 172 7561785 YP_002643353.1 CDS PE_PGRS3 NC_012207.1 334880 337579 R In Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a insertion of 66 bp lead to a longer product than to the homolog Mycobacterium bovis (899 aa versus 877 aa). In Mycobacterium bovis, 2 deletions, one of 18 bp and the other of 66 bp, and part of a 2780 bp insertion , leads to a shorter product with a different 3' end compared to its homolog in Mycobacterium tuberculosis strain H37Rv (877 aa versus 957 aa); PE-PGRS family protein complement(334880..337579) Mycobacterium bovis BCG str. Tokyo 172 7561784 YP_002643354.1 CDS PE_PGRS4 NC_012207.1 337829 340333 R In Mycobacterium bovis BCG Pasteur, and BCG Tokyo, 2 insertionseach of 9 bp and a deletion of 9 bp, lead to a longer product compared to its homolog in Mycobacterium bovis (834 aa versus 831 aa). In Mycobacterium bovis, 2 deletions each of 9 bp (CCGCCGGCG-* and CCCGCCGGC-*), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (831 aa versus 837 aa); PE-PGRS family protein complement(337829..340333) Mycobacterium bovis BCG str. Tokyo 172 7561771 YP_002643355.1 CDS PPE3 NC_012207.1 340624 342234 D Differs from Rv0280 by 1 aa P337S in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; PPE family protein 340624..342234 Mycobacterium bovis BCG str. Tokyo 172 7561786 YP_002643356.1 CDS JTY_0291 NC_012207.1 342258 343166 D hypothetical protein 342258..343166 Mycobacterium bovis BCG str. Tokyo 172 7562167 YP_002643357.1 CDS JTY_0292 NC_012207.1 343390 345285 D Differs from Rv0282 by 1aa, A6E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein 343390..345285 Mycobacterium bovis BCG str. Tokyo 172 7563031 YP_002643358.1 CDS JTY_0293 NC_012207.1 345282 346898 D hypothetical protein 345282..346898 Mycobacterium bovis BCG str. Tokyo 172 7563032 YP_002643359.1 CDS JTY_0294 NC_012207.1 346895 350887 D Differs from Mb0292 by 1aa, A134T, and from Rv0284 by 2aa, A134T, R214P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 346895..350887 Mycobacterium bovis BCG str. Tokyo 172 7563033 YP_002643360.1 CDS PE5 NC_012207.1 350884 351192 D PE family protein 350884..351192 Mycobacterium bovis BCG str. Tokyo 172 7563034 YP_002643361.1 CDS PPE4 NC_012207.1 351195 352736 D PPE family protein 351195..352736 Mycobacterium bovis BCG str. Tokyo 172 7561736 YP_002643362.1 CDS esxG NC_012207.1 352785 353078 D hypothetical protein 352785..353078 Mycobacterium bovis BCG str. Tokyo 172 7562178 YP_002643363.1 CDS esxH NC_012207.1 353108 353398 D low molecular weight protein antigen 7 353108..353398 Mycobacterium bovis BCG str. Tokyo 172 7562878 YP_002643364.1 CDS JTY_0299 NC_012207.1 353409 354296 D hypothetical protein 353409..354296 Mycobacterium bovis BCG str. Tokyo 172 7562879 YP_002643365.1 CDS JTY_0300 NC_012207.1 354343 355761 D Differs from Rv0290 by 1aa, T400A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 354343..355761 Mycobacterium bovis BCG str. Tokyo 172 7563035 YP_002643366.1 CDS JTY_0301 NC_012207.1 355758 357143 D protease precursor 355758..357143 Mycobacterium bovis BCG str. Tokyo 172 7563036 YP_002643367.1 CDS JTY_0302 NC_012207.1 357140 358135 D Differs from Rv0292 by 1aa, D217N in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 357140..358135 Mycobacterium bovis BCG str. Tokyo 172 7563037 YP_002643368.1 CDS JTY_0303 NC_012207.1 358122 359324 R Differs from Rv0293c and Mb0301c by 1aa, S263G in BCG Pasteur and BCG Tokyo; hypothetical protein complement(358122..359324) Mycobacterium bovis BCG str. Tokyo 172 7563038 YP_002643369.1 CDS tam NC_012207.1 359431 360216 D catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 359431..360216 Mycobacterium bovis BCG str. Tokyo 172 7563039 YP_002643370.1 CDS JTY_0305 NC_012207.1 360205 361008 R hypothetical protein complement(360205..361008) Mycobacterium bovis BCG str. Tokyo 172 7561822 YP_002643371.1 CDS JTY_0306 NC_012207.1 361018 362415 R sulfatase complement(361018..362415) Mycobacterium bovis BCG str. Tokyo 172 7563040 YP_002643372.1 CDS PE_PGRS5 NC_012207.1 362594 364414 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (606 aa versus 591 aa); PE-PGRS family protein 362594..364414 Mycobacterium bovis BCG str. Tokyo 172 7563041 YP_002643373.1 CDS JTY_0308 NC_012207.1 364557 364784 D hypothetical protein 364557..364784 Mycobacterium bovis BCG str. Tokyo 172 7562375 YP_002643374.1 CDS JTY_0309 NC_012207.1 364781 365083 D Differs from Mb0307 by 1aa, S13N in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 364781..365083 Mycobacterium bovis BCG str. Tokyo 172 7563042 YP_002643375.1 CDS JTY_0310 NC_012207.1 365131 365352 D hypothetical protein 365131..365352 Mycobacterium bovis BCG str. Tokyo 172 7563043 YP_002643376.1 CDS JTY_0311 NC_012207.1 365349 365774 D hypothetical protein 365349..365774 Mycobacterium bovis BCG str. Tokyo 172 7563044 YP_002643377.1 CDS JTY_0312 NC_012207.1 365911 366543 D Differs from Mb0310 by 1aa A124V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably TetR/AcrR-family; transcriptional regulatory protein 365911..366543 Mycobacterium bovis BCG str. Tokyo 172 7563045 YP_002643378.1 CDS JTY_0313 NC_012207.1 366540 367448 D dehydrogenase/reductase 366540..367448 Mycobacterium bovis BCG str. Tokyo 172 7563046 YP_002643379.1 CDS PPE5 NC_012207.1 367456 370899 R In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (G-*) leads to a shorter CDS (Mycobacterium bovis, BCG Pasteur, and BCG Tokyo) equivalent to the 3' end of Rv0304c/PPE5. Differs from Rv0304c by 3aa, S481G, F708S, A955T, and 5 codon in-frame deletion at position 503 in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; PPE family protein complement(367456..370899) Mycobacterium bovis BCG str. Tokyo 172 7563047 YP_002643380.1 CDS PPE6 NC_012207.1 371043 376970 R In Mycobacterium tuberculosis strain H37Rv, PPE5 and PPE6 exist as separate genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base deletion (T-*) resulting in the absence of a stop codon leads to a longer product. The second part of this CDS shares homology with the 5' end of Rv0304c/PPE5. Differs from Mb0313c by in-frame deletion of 10 codons in BCG Pasteur and BCG Tokyo.; PPE family protein complement(371043..376970) Mycobacterium bovis BCG str. Tokyo 172 7562188 YP_002643381.1 CDS JTY_0316 NC_012207.1 377173 377844 D oxidoreductase 377173..377844 Mycobacterium bovis BCG str. Tokyo 172 7561542 YP_002643382.1 CDS JTY_0317 NC_012207.1 377832 378314 R hypothetical protein complement(377832..378314) Mycobacterium bovis BCG str. Tokyo 172 7563048 YP_002643383.1 CDS JTY_0318 NC_012207.1 378372 379088 D integral membrane protein 378372..379088 Mycobacterium bovis BCG str. Tokyo 172 7563049 YP_002643384.1 CDS JTY_0319 NC_012207.1 379190 379846 D hypothetical protein 379190..379846 Mycobacterium bovis BCG str. Tokyo 172 7563050 YP_002643385.1 CDS JTY_0320 NC_012207.1 379916 380407 R hypothetical protein complement(379916..380407) Mycobacterium bovis BCG str. Tokyo 172 7563051 YP_002643386.1 CDS JTY_0321 NC_012207.1 380431 381660 D hypothetical protein 380431..381660 Mycobacterium bovis BCG str. Tokyo 172 7563052 YP_002643387.1 CDS JTY_0322 NC_012207.1 381815 383677 D Differs from Rv0312 by 2aa, G159S, L563P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 381815..383677 Mycobacterium bovis BCG str. Tokyo 172 7563053 YP_002643388.1 CDS JTY_0323 NC_012207.1 383749 384135 D hypothetical protein 383749..384135 Mycobacterium bovis BCG str. Tokyo 172 7563054 YP_002643389.1 CDS JTY_0324 NC_012207.1 384138 384800 R Differs from Rv0314c by 1aa, A184V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein complement(384138..384800) Mycobacterium bovis BCG str. Tokyo 172 7563055 YP_002643390.1 CDS JTY_0325 NC_012207.1 384861 385745 D Differs from Rv0315 by 1aa, T260K in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; beta-1,3-glucanase precursor 384861..385745 Mycobacterium bovis BCG str. Tokyo 172 7563056 YP_002643391.1 CDS JTY_0326 NC_012207.1 385794 386408 D muconolactone isomerase 385794..386408 Mycobacterium bovis BCG str. Tokyo 172 7563057 YP_002643392.1 CDS glpQ2 NC_012207.1 386432 387202 R glycerophosphoryl diester phosphodiesterase complement(386432..387202) Mycobacterium bovis BCG str. Tokyo 172 7563058 YP_002643393.1 CDS JTY_0328 NC_012207.1 387564 388358 R Differs from Rv0318c by 1aa, A223G in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein complement(387564..388358) Mycobacterium bovis BCG str. Tokyo 172 7563268 YP_002643394.1 CDS pcp NC_012207.1 388407 389075 D catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 388407..389075 Mycobacterium bovis BCG str. Tokyo 172 7563059 YP_002643395.1 CDS JTY_0330 NC_012207.1 389147 389809 D hypothetical protein 389147..389809 Mycobacterium bovis BCG str. Tokyo 172 7562525 YP_002643396.1 CDS dcd NC_012207.1 389841 390413 D Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 389841..390413 Mycobacterium bovis BCG str. Tokyo 172 7563060 YP_002643397.1 CDS udgA NC_012207.1 390519 391850 D UDP-glucose 6-dehydrogenase 390519..391850 Mycobacterium bovis BCG str. Tokyo 172 7561470 YP_002643398.1 CDS JTY_0333 NC_012207.1 391839 392510 R Differs from Rv0323c by 1aa, G142S in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein complement(391839..392510) Mycobacterium bovis BCG str. Tokyo 172 7561650 YP_002643399.1 CDS JTY_0334 NC_012207.1 392611 393291 D Differs from Rv0324 by 1aa, A168T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; possibly ArsR-family; transcriptional regulatory protein 392611..393291 Mycobacterium bovis BCG str. Tokyo 172 7563061 YP_002643400.1 CDS JTY_0335 NC_012207.1 393298 393987 D In Mycobacterium tuberculosis strain H37Rv, Rv0325 and Rv0326 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, the absence of a stop codon between Rv0325 and Rv0326 due to a single base transition (T-C) leads to single product; hypothetical protein 393298..393987 Mycobacterium bovis BCG str. Tokyo 172 7563062 YP_002643401.1 CDS cyp135A1 NC_012207.1 393955 395304 R Differs from Rv0327c by 1aa, Y100H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; cytochrome P450 135A1 complement(393955..395304) Mycobacterium bovis BCG str. Tokyo 172 7563063 YP_002643402.1 CDS JTY_0337 NC_012207.1 395370 395972 D possibly TetR/AcrR-family; transcriptional regulatory protein 395370..395972 Mycobacterium bovis BCG str. Tokyo 172 7563160 YP_002643403.1 CDS JTY_0338 NC_012207.1 395953 396579 R Differs from Rv0329c by 1aa, S129W in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(395953..396579) Mycobacterium bovis BCG str. Tokyo 172 7563064 YP_002643404.1 CDS JTY_0339 NC_012207.1 396606 397346 R hypothetical protein complement(396606..397346) Mycobacterium bovis BCG str. Tokyo 172 7563065 YP_002643405.1 CDS JTY_0340 NC_012207.1 397460 398626 D dehydrogenase/reductase 397460..398626 Mycobacterium bovis BCG str. Tokyo 172 7563066 YP_002643406.1 CDS JTY_0341 NC_012207.1 398701 399486 D Differs from Rv0332 by 1aa, G198E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 398701..399486 Mycobacterium bovis BCG str. Tokyo 172 7563067 YP_002643407.1 CDS JTY_0342 NC_012207.1 399513 399887 D hypothetical protein 399513..399887 Mycobacterium bovis BCG str. Tokyo 172 7563068 YP_002643408.1 CDS rmlA NC_012207.1 399917 400783 D glucose-1-phosphate thymidylyltransferase 399917..400783 Mycobacterium bovis BCG str. Tokyo 172 7563069 YP_002643409.1 CDS PE6 NC_012207.1 400794 401309 R Differs from Rv0335c and Mb0340 by 1aa P131T in BCG Pasteur and BCG Tokyo; PE family protein complement(400794..401309) Mycobacterium bovis BCG str. Tokyo 172 7561581 YP_002643410.1 CDS aspC NC_012207.1 403133 404422 R broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase complement(403133..404422) Mycobacterium bovis BCG str. Tokyo 172 7563070 YP_002643411.1 CDS JTY_0347 NC_012207.1 404453 407101 R Differs from Rv0338c by 2aa, G506R, V621A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; iron-sulfur-binding reductase complement(404453..407101) Mycobacterium bovis BCG str. Tokyo 172 7562044 YP_002643412.1 CDS JTY_0348 NC_012207.1 407210 409708 R transcriptional regulatory protein complement(407210..409708) Mycobacterium bovis BCG str. Tokyo 172 7563071 YP_002643413.1 CDS JTY_0349 NC_012207.1 409894 410433 D hypothetical protein 409894..410433 Mycobacterium bovis BCG str. Tokyo 172 7563072 YP_002643414.1 CDS iniB NC_012207.1 410622 412061 D isoniazid inductible gene protein 410622..412061 Mycobacterium bovis BCG str. Tokyo 172 7563073 YP_002643415.1 CDS iniA NC_012207.1 412098 414020 D Differs from by 2aa, S88N, Q481H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; isoniazid inductible gene protein 412098..414020 Mycobacterium bovis BCG str. Tokyo 172 7562790 YP_002643416.1 CDS iniC NC_012207.1 414017 415498 D isoniazid inductible gene protein 414017..415498 Mycobacterium bovis BCG str. Tokyo 172 7562789 YP_002643417.1 CDS lpqJ NC_012207.1 415641 416201 R lipoprotein complement(415641..416201) Mycobacterium bovis BCG str. Tokyo 172 7562791 YP_002643418.1 CDS JTY_0354 NC_012207.1 416310 416720 D In Mycobacterium bovis, a frameshift due to a single base deletion (A-*) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv in Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 416310..416720 Mycobacterium bovis BCG str. Tokyo 172 7560502 YP_002643419.1 CDS ansP2 NC_012207.1 416762 418225 R L-asparagine permease complement(416762..418225) Mycobacterium bovis BCG str. Tokyo 172 7563074 YP_002643420.1 CDS JTY_0356 NC_012207.1 418564 419550 D hypothetical protein 418564..419550 Mycobacterium bovis BCG str. Tokyo 172 7563978 YP_002643421.1 CDS JTY_0357 NC_012207.1 419553 420206 D transcriptional regulatory protein 419553..420206 Mycobacterium bovis BCG str. Tokyo 172 7563075 YP_002643422.1 CDS JTY_0358 NC_012207.1 420209 420868 D hypothetical protein 420209..420868 Mycobacterium bovis BCG str. Tokyo 172 7563076 YP_002643423.1 CDS dnaK NC_012207.1 421095 422972 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 421095..422972 Mycobacterium bovis BCG str. Tokyo 172 7563077 YP_002643424.1 CDS grpE NC_012207.1 422969 423676 D with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 422969..423676 Mycobacterium bovis BCG str. Tokyo 172 7561506 YP_002643425.1 CDS dnaJ1 NC_012207.1 423712 424899 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 423712..424899 Mycobacterium bovis BCG str. Tokyo 172 7563285 YP_002643426.1 CDS hspR NC_012207.1 424899 425279 D MerR family; heat shock protein transcriptional regulator 424899..425279 Mycobacterium bovis BCG str. Tokyo 172 7561504 YP_002643427.1 CDS PPE8 NC_012207.1 425302 435825 R In Mycobacterium tuberculosis strain H37Rv, PPE7 and PPE8 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 2 bp insertion (*-TA) resulting in the absence of a stop codon between the 2 genes, leads to a single product, and an altered C-terminus; PPE family protein complement(425302..435825) Mycobacterium bovis BCG str. Tokyo 172 7563329 YP_002643428.1 CDS JTY_0364 NC_012207.1 435976 436620 R hypothetical protein complement(435976..436620) Mycobacterium bovis BCG str. Tokyo 172 7560803 YP_002643429.1 CDS purA NC_012207.1 436617 437915 R catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase complement(436617..437915) Mycobacterium bovis BCG str. Tokyo 172 7563078 YP_002643430.1 CDS JTY_0366 NC_012207.1 438006 438653 D hypothetical protein 438006..438653 Mycobacterium bovis BCG str. Tokyo 172 7560854 YP_002643431.1 CDS JTY_0367 NC_012207.1 438664 439443 D Differs from Rv0359 by 1aa, T252A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein 438664..439443 Mycobacterium bovis BCG str. Tokyo 172 7563079 YP_002643432.1 CDS JTY_0368 NC_012207.1 439448 439885 R hypothetical protein complement(439448..439885) Mycobacterium bovis BCG str. Tokyo 172 7563080 YP_002643433.1 CDS JTY_0369 NC_012207.1 439968 440795 D hypothetical protein 439968..440795 Mycobacterium bovis BCG str. Tokyo 172 7563081 YP_002643434.1 CDS mgtE NC_012207.1 441017 442399 D Differs from Mb0362 by 1aa, V292A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; Mg2+ transport transmembrane protein 441017..442399 Mycobacterium bovis BCG str. Tokyo 172 7563082 YP_002643435.1 CDS fba NC_012207.1 442411 443445 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(442411..443445) Mycobacterium bovis BCG str. Tokyo 172 7564471 YP_002643436.1 CDS JTY_0372 NC_012207.1 443541 444224 D Differs from Rv0364 by 1aa, L193I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 443541..444224 Mycobacterium bovis BCG str. Tokyo 172 7563396 YP_002643437.1 CDS JTY_0373 NC_012207.1 444213 445343 R hypothetical protein complement(444213..445343) Mycobacterium bovis BCG str. Tokyo 172 7563083 YP_002643438.1 CDS JTY_0374 NC_012207.1 445368 445961 R hypothetical protein complement(445368..445961) Mycobacterium bovis BCG str. Tokyo 172 7563084 YP_002643439.1 CDS JTY_0375 NC_012207.1 445990 446379 R hypothetical protein complement(445990..446379) Mycobacterium bovis BCG str. Tokyo 172 7563085 YP_002643440.1 CDS JTY_0376 NC_012207.1 446460 447671 R Differs from Rv0368c by 1aa, H249R, and from Mb0375c by 1aa, G371S in BCG Pasteur and BCG Tokyo; hypothetical protein complement(446460..447671) Mycobacterium bovis BCG str. Tokyo 172 7563086 YP_002643441.1 CDS JTY_0377 NC_012207.1 447677 448192 R membrane oxidoreductase complement(447677..448192) Mycobacterium bovis BCG str. Tokyo 172 7563087 YP_002643442.1 CDS JTY_0378 NC_012207.1 448293 449189 R Differs from Rv0370c by 1aa, E201G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase complement(448293..449189) Mycobacterium bovis BCG str. Tokyo 172 7563088 YP_002643443.1 CDS JTY_0379 NC_012207.1 449186 449779 R hypothetical protein complement(449186..449779) Mycobacterium bovis BCG str. Tokyo 172 7563089 YP_002643444.1 CDS JTY_0380 NC_012207.1 449776 450531 R Differs from Mb0379c by 1aa, G161S in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein complement(449776..450531) Mycobacterium bovis BCG str. Tokyo 172 7563090 YP_002643445.1 CDS JTY_0381 NC_012207.1 450550 452949 R Differs from Rv0373c by 1aa, S122F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; carbon monoxide dehydrogenase large chain complement(450550..452949) Mycobacterium bovis BCG str. Tokyo 172 7563091 YP_002643446.1 CDS JTY_0382 NC_012207.1 452946 453425 R carbon monoxide dehydrogenase small chain complement(452946..453425) Mycobacterium bovis BCG str. Tokyo 172 7563092 YP_002643447.1 CDS JTY_0383 NC_012207.1 453440 454300 R carbon monoxide dehydrogenase medium chain complement(453440..454300) Mycobacterium bovis BCG str. Tokyo 172 7563093 YP_002643448.1 CDS JTY_0384 NC_012207.1 454376 455518 R hypothetical protein complement(454376..455518) Mycobacterium bovis BCG str. Tokyo 172 7563094 YP_002643449.1 CDS JTY_0385 NC_012207.1 455567 456532 D Differs from Rv0377 by 1aa, R302P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably LysR-family; transcriptional regulatory protein 455567..456532 Mycobacterium bovis BCG str. Tokyo 172 7563095 YP_002643450.1 CDS JTY_0386 NC_012207.1 456783 457004 D hypothetical glycine rich protein 456783..457004 Mycobacterium bovis BCG str. Tokyo 172 7563096 YP_002643451.1 CDS secE2 NC_012207.1 457123 457338 D protein transport protein 457123..457338 Mycobacterium bovis BCG str. Tokyo 172 7563097 YP_002643452.1 CDS JTY_0388 NC_012207.1 457414 457965 R RNA methyltransferase complement(457414..457965) Mycobacterium bovis BCG str. Tokyo 172 7560774 YP_002643453.1 CDS JTY_0389 NC_012207.1 458061 458969 R hypothetical protein complement(458061..458969) Mycobacterium bovis BCG str. Tokyo 172 7563098 YP_002643454.1 CDS pyrE NC_012207.1 458987 459526 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(458987..459526) Mycobacterium bovis BCG str. Tokyo 172 7563099 YP_002643455.1 CDS JTY_0391 NC_012207.1 459607 460461 R hypothetical protein complement(459607..460461) Mycobacterium bovis BCG str. Tokyo 172 7560873 YP_002643456.1 CDS clpB NC_012207.1 460602 463148 R endopeptidase ATP binding protein chain b complement(460602..463148) Mycobacterium bovis BCG str. Tokyo 172 7563100 YP_002643457.1 CDS JTY_0393 NC_012207.1 463281 464453 D monooxygenase 463281..464453 Mycobacterium bovis BCG str. Tokyo 172 7562107 YP_002643458.1 CDS JTY_0394 NC_012207.1 464557 467814 D Differs from Mb0393 by 1aa, D902A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably LuxR/UhpA-family; transcriptional regulatory protein 464557..467814 Mycobacterium bovis BCG str. Tokyo 172 7563101 YP_002643459.1 CDS PPE9 NC_012207.1 467818 469149 R In Mycobacterium tuberculosis strain H37Rv, Rv0388c and Rv0387c exist as 2 separate genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, 3 different base substitutions, the first of 14 bases, the second of 8 bases (TCTACAGT-GCTACAGG), and lastly of 28 bases, leads to a longer single product. Differs from Mb0394c by 1aa, T361A in BCG Pasteur and BCG Tokyo.; PPE family protein complement(467818..469149) Mycobacterium bovis BCG str. Tokyo 172 7561122 YP_002643460.1 CDS purT NC_012207.1 469483 470742 D non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 469483..470742 Mycobacterium bovis BCG str. Tokyo 172 7560804 YP_002643461.1 CDS JTY_0397 NC_012207.1 470739 471161 D hypothetical protein 470739..471161 Mycobacterium bovis BCG str. Tokyo 172 7560866 YP_002643462.1 CDS metZ NC_012207.1 471158 472378 D O-succinylhomoserine sulfhydrylase 471158..472378 Mycobacterium bovis BCG str. Tokyo 172 7561123 YP_002643463.1 CDS ndhA NC_012207.1 472375 473787 R Differs from Rv0392c by 1aa, A241V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; membrane NADH dehydrogenase complement(472375..473787) Mycobacterium bovis BCG str. Tokyo 172 7564468 YP_002643464.1 CDS JTY_0400 NC_012207.1 473929 475254 D conserved 13E12 repeat family protein 473929..475254 Mycobacterium bovis BCG str. Tokyo 172 7562457 YP_002643465.1 CDS JTY_0401 NC_012207.1 475270 475989 R hypothetical protein complement(475270..475989) Mycobacterium bovis BCG str. Tokyo 172 7561124 YP_002643466.1 CDS JTY_0402 NC_012207.1 476088 476492 D Differs from Rv0395 by 1aa, A80V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein 476088..476492 Mycobacterium bovis BCG str. Tokyo 172 7561125 YP_002643467.1 CDS JTY_0403 NC_012207.1 476498 476890 D hypothetical protein 476498..476890 Mycobacterium bovis BCG str. Tokyo 172 7561126 YP_002643468.1 CDS JTY_0404 NC_012207.1 476964 477332 D conserved 13E12 repeat family protein 476964..477332 Mycobacterium bovis BCG str. Tokyo 172 7561127 YP_002643469.1 CDS JTY_0405 NC_012207.1 477827 478468 R hypothetical protein complement(477827..478468) Mycobacterium bovis BCG str. Tokyo 172 7561128 YP_002643470.1 CDS lpqK NC_012207.1 478475 479704 R lipoprotein complement(478475..479704) Mycobacterium bovis BCG str. Tokyo 172 7561129 YP_002643471.1 CDS fadE7 NC_012207.1 479714 480901 R acyl-CoA dehydrogenase complement(479714..480901) Mycobacterium bovis BCG str. Tokyo 172 7560503 YP_002643472.1 CDS JTY_0408 NC_012207.1 480937 481308 D transmembrane protein 480937..481308 Mycobacterium bovis BCG str. Tokyo 172 7563390 YP_002643473.1 CDS mmpL1b NC_012207.1 481503 482606 R In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (C-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b; transmembrane transport protein complement(481503..482606) Mycobacterium bovis BCG str. Tokyo 172 7561130 YP_002643474.1 CDS mmpL1a NC_012207.1 482603 484378 R In Mycobacterium tuberculosis strain H37Rv, mmpL1 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (C-*) splits mmpL1 into 2 parts, mmpL1a and mmpL1b. Differs from Rv0402c by 1aa, P451L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane transport protein complement(482603..484378) Mycobacterium bovis BCG str. Tokyo 172 7564486 YP_002643475.1 CDS mmpS1 NC_012207.1 484375 484803 R hypothetical protein complement(484375..484803) Mycobacterium bovis BCG str. Tokyo 172 7564485 YP_002643476.1 CDS fadD30 NC_012207.1 485124 486881 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 485124..486881 Mycobacterium bovis BCG str. Tokyo 172 7564496 YP_002643477.1 CDS pks6a NC_012207.1 486878 488260 D In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to single base insertion (*-G) splits pks6 into 2 parts,pks6a and pks6b; membrane bound polyketide synthase 486878..488260 Mycobacterium bovis BCG str. Tokyo 172 7562936 YP_002643478.1 CDS pks6b NC_012207.1 488247 491087 D In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis, a frameshift due to single base insertion (*-G), splits pks6 into 2 parts, pks6a and pks6b. Differs from Mb0413 by 1aa, M921V in BCG Pasteur and BCG Tokyo; membrane bound polyketide synthase 488247..491087 Mycobacterium bovis BCG str. Tokyo 172 7562122 YP_002643479.1 CDS JTY_0415 NC_012207.1 491035 491853 R beta lactamase like protein complement(491035..491853) Mycobacterium bovis BCG str. Tokyo 172 7562123 YP_002643480.1 CDS fgd1 NC_012207.1 491931 492941 D F420-dependent glucose-6-phosphate dehydrogenase 491931..492941 Mycobacterium bovis BCG str. Tokyo 172 7561131 YP_002643481.1 CDS pta NC_012207.1 492934 495006 D catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 492934..495006 Mycobacterium bovis BCG str. Tokyo 172 7563412 YP_002643482.1 CDS ackA NC_012207.1 494999 496156 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 494999..496156 Mycobacterium bovis BCG str. Tokyo 172 7560849 YP_002643483.1 CDS pknG NC_012207.1 496210 498462 R serine/threonine-protein kinase complement(496210..498462) Mycobacterium bovis BCG str. Tokyo 172 7563929 YP_002643484.1 CDS glnH NC_012207.1 498462 499448 R glutamine-binding lipoprotein complement(498462..499448) Mycobacterium bovis BCG str. Tokyo 172 7562434 YP_002643485.1 CDS JTY_0421 NC_012207.1 499448 500767 R Differs from Rv0412c by 1aa, Y355D in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein complement(499448..500767) Mycobacterium bovis BCG str. Tokyo 172 7561933 YP_002643486.1 CDS mutT3 NC_012207.1 500861 501514 D 7,8-dihydro-8-oxoguanine-triphosphatase, 8-oxo-dGTPase, dGTP pyrophosphohydrolase; mutator protein 500861..501514 Mycobacterium bovis BCG str. Tokyo 172 7561132 YP_002643487.1 CDS thiE NC_012207.1 501498 502166 R Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase complement(501498..502166) Mycobacterium bovis BCG str. Tokyo 172 7563583 YP_002643488.1 CDS thiO NC_012207.1 502296 503318 D Differs from Mb0423 by 1aa, A158V in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; thiamine biosynthesis oxidoreductase 502296..503318 Mycobacterium bovis BCG str. Tokyo 172 7561844 YP_002643489.1 CDS thiS NC_012207.1 503315 503521 D with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 503315..503521 Mycobacterium bovis BCG str. Tokyo 172 7561847 YP_002643490.1 CDS thiG NC_012207.1 503514 504272 D functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 503514..504272 Mycobacterium bovis BCG str. Tokyo 172 7561848 YP_002643491.1 CDS lpqL NC_012207.1 504644 506146 D lipoprotein aminopeptidase 504644..506146 Mycobacterium bovis BCG str. Tokyo 172 7561845 YP_002643492.1 CDS lpqM NC_012207.1 506234 507730 D Differs from Rv0419 by 2aa, T73A, T297A, and from Mb0427 by 1aa, T73A in BCG Pasteur and BCG Tokyo; lipoprotein peptidase 506234..507730 Mycobacterium bovis BCG str. Tokyo 172 7560504 YP_002643493.1 CDS JTY_0429 NC_012207.1 507709 508119 R Differs from Mb0428c by 1aa, G21E in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; transmembrane protein complement(507709..508119) Mycobacterium bovis BCG str. Tokyo 172 7560505 YP_002643494.1 CDS JTY_0430 NC_012207.1 508280 508909 R hypothetical protein complement(508280..508909) Mycobacterium bovis BCG str. Tokyo 172 7561133 YP_002643495.1 CDS thiD NC_012207.1 508906 509703 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(508906..509703) Mycobacterium bovis BCG str. Tokyo 172 7561134 YP_002643496.1 CDS thiC NC_012207.1 509730 511373 R required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC complement(509730..511373) Mycobacterium bovis BCG str. Tokyo 172 7561843 YP_002643497.1 CDS JTY_0433 NC_012207.1 511525 511800 R hypothetical protein complement(511525..511800) Mycobacterium bovis BCG str. Tokyo 172 7561842 YP_002643498.1 CDS ctpH NC_012207.1 511850 516469 R Differs from Rv0425c by 1aa, A222E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; metal cation transporting P-type ATPase complement(511850..516469) Mycobacterium bovis BCG str. Tokyo 172 7561135 YP_002643499.1 CDS JTY_0435 NC_012207.1 516521 516964 R transmembrane protein complement(516521..516964) Mycobacterium bovis BCG str. Tokyo 172 7563138 YP_002643500.1 CDS xthA NC_012207.1 517165 518040 R exodeoxyribonuclease III protein complement(517165..518040) Mycobacterium bovis BCG str. Tokyo 172 7561136 YP_002643501.1 CDS JTY_0437 NC_012207.1 518043 518951 R Differs from Rv0428c by 1aa G149D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein complement(518043..518951) Mycobacterium bovis BCG str. Tokyo 172 7561700 YP_002643502.1 CDS def NC_012207.1 518951 519544 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(518951..519544) Mycobacterium bovis BCG str. Tokyo 172 7561137 YP_002643503.1 CDS JTY_0439 NC_012207.1 519881 520189 D hypothetical protein 519881..520189 Mycobacterium bovis BCG str. Tokyo 172 7561475 YP_002643504.1 CDS JTY_0440 NC_012207.1 520221 520715 D Differs from Rv0431 by 2aa, G38V, A87T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; tuberculin related peptide 520221..520715 Mycobacterium bovis BCG str. Tokyo 172 7561138 YP_002643505.1 CDS sodC NC_012207.1 520748 521470 D periplasmic Cu-Zn-superoxide dismutase 520748..521470 Mycobacterium bovis BCG str. Tokyo 172 7561139 YP_002643506.1 CDS JTY_0442 NC_012207.1 521472 522602 D ATP-dependent carboxylate-amine ligase; carboxylate-amine ligase 521472..522602 Mycobacterium bovis BCG str. Tokyo 172 7561803 YP_002643507.1 CDS JTY_0443 NC_012207.1 522662 523315 D Differs from Rv0434 by 1aa, A190T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein 522662..523315 Mycobacterium bovis BCG str. Tokyo 172 7561140 YP_002643508.1 CDS JTY_0444 NC_012207.1 523495 525681 R ATPase complement(523495..525681) Mycobacterium bovis BCG str. Tokyo 172 7561141 YP_002643509.1 CDS pssA NC_012207.1 525678 526538 R Differs from Rv0436c by 1aa, V167G in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis BCG Pasteur, and BCVG Tokyo; CDP-diacylglycerol--serine O-phosphatidyltransferase complement(525678..526538) Mycobacterium bovis BCG str. Tokyo 172 7561142 YP_002643510.1 CDS psd NC_012207.1 526535 527230 R catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase complement(526535..527230) Mycobacterium bovis BCG str. Tokyo 172 7560839 YP_002643511.1 CDS moeA2 NC_012207.1 527291 528508 R Differs from Rv0438c by 1aa, I15M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; molybdopterin biosynthesis protein complement(527291..528508) Mycobacterium bovis BCG str. Tokyo 172 7560838 YP_002643512.1 CDS JTY_0448 NC_012207.1 528527 529462 R short chain dehydrogenase complement(528527..529462) Mycobacterium bovis BCG str. Tokyo 172 7563540 YP_002643513.1 CDS groEL NC_012207.1 529756 531378 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 529756..531378 Mycobacterium bovis BCG str. Tokyo 172 7561143 YP_002643514.1 CDS JTY_0450 NC_012207.1 531444 531872 R hypothetical protein complement(531444..531872) Mycobacterium bovis BCG str. Tokyo 172 7563282 YP_002643515.1 CDS PPE10 NC_012207.1 531899 533338 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (G-A) creates an in-frame stop at codon 8, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (479 aa versus 487 aa). Differs from Mb0450c by 1aa, T214K, and from Rv0442c by 2aa, E23K, T214K in BCG Pasteur and BCG Tokyo.; PPE family protein complement(531899..533338) Mycobacterium bovis BCG str. Tokyo 172 7561144 YP_002643516.1 CDS JTY_0452 NC_012207.1 533544 534059 D hypothetical protein 533544..534059 Mycobacterium bovis BCG str. Tokyo 172 7562145 YP_002643517.1 CDS JTY_0453 NC_012207.1 534239 534937 R Differs from Rv0444c by 2aa, D107G, E184G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein complement(534239..534937) Mycobacterium bovis BCG str. Tokyo 172 7561145 YP_002643518.1 CDS sigK NC_012207.1 534981 535544 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins; RNA polymerase sigma factor SigK complement(534981..535544) Mycobacterium bovis BCG str. Tokyo 172 7561146 YP_002643519.1 CDS JTY_0455 NC_012207.1 535593 536363 R transmembrane protein complement(535593..536363) Mycobacterium bovis BCG str. Tokyo 172 7561795 YP_002643520.1 CDS ufaA1 NC_012207.1 536372 537655 R cyclopropane-fatty-acyl-phospholipid synthase complement(536372..537655) Mycobacterium bovis BCG str. Tokyo 172 7561147 YP_002643521.1 CDS JTY_0457 NC_012207.1 537652 538317 R hypothetical protein complement(537652..538317) Mycobacterium bovis BCG str. Tokyo 172 7561651 YP_002643522.1 CDS JTY_0458 NC_012207.1 538377 539696 R hypothetical protein complement(538377..539696) Mycobacterium bovis BCG str. Tokyo 172 7561148 YP_002643523.1 CDS mmpL4 NC_012207.1 539736 542639 R Differs from Mb0458c by 1aa, A314T in BCG Pasteur and BCG Tokyo; transmembrane transport protein complement(539736..542639) Mycobacterium bovis BCG str. Tokyo 172 7561149 YP_002643524.1 CDS mmpS4 NC_012207.1 542636 543058 R hypothetical protein complement(542636..543058) Mycobacterium bovis BCG str. Tokyo 172 7564489 YP_002643525.1 CDS JTY_0461 NC_012207.1 543290 544000 D transcriptional regulatory protein 543290..544000 Mycobacterium bovis BCG str. Tokyo 172 7563514 YP_002643526.1 CDS PPE11 NC_012207.1 544322 545878 D PPE family protein 544322..545878 Mycobacterium bovis BCG str. Tokyo 172 7561150 YP_002643527.1 CDS JTY_0463 NC_012207.1 545983 546333 D hypothetical protein 545983..546333 Mycobacterium bovis BCG str. Tokyo 172 7562146 YP_002643528.1 CDS JTY_0464 NC_012207.1 546523 546969 R hypothetical protein complement(546523..546969) Mycobacterium bovis BCG str. Tokyo 172 7561151 YP_002643529.1 CDS echA2 NC_012207.1 547037 547951 R catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(547037..547951) Mycobacterium bovis BCG str. Tokyo 172 7561152 YP_002643530.1 CDS JTY_0466 NC_012207.1 548224 548505 R hypothetical protein complement(548224..548505) Mycobacterium bovis BCG str. Tokyo 172 7561531 YP_002643531.1 CDS JTY_0467 NC_012207.1 548734 550764 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a possible RBS upstream leads to an earlier start resulting in a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (676 aa versus 673 aa); peptidase complement(548734..550764) Mycobacterium bovis BCG str. Tokyo 172 7561153 YP_002643532.1 CDS JTY_0468 NC_012207.1 550823 552346 D aldehyde dehydrogenase 550823..552346 Mycobacterium bovis BCG str. Tokyo 172 7561154 YP_002643533.1 CDS JTY_0469 NC_012207.1 552346 552837 D hypothetical protein 552346..552837 Mycobacterium bovis BCG str. Tokyo 172 7561155 YP_002643534.1 CDS JTY_0470 NC_012207.1 552897 553136 D conserved hydrophobic protein 552897..553136 Mycobacterium bovis BCG str. Tokyo 172 7561156 YP_002643535.1 CDS JTY_0471 NC_012207.1 553174 553698 D transmembrane protein 553174..553698 Mycobacterium bovis BCG str. Tokyo 172 7561157 YP_002643536.1 CDS lpd NC_012207.1 553762 555156 D E3 component of alpha keto acid dehydrogenase complexes LpdC; forms a homodimer; binds one molecule of FAD monomer; catalyzes NAD+-dependent oxidation of dihydrolipoyl cofactors that are covalently linked to the E2 component; dihydrolipoamide dehydrogenase 553762..555156 Mycobacterium bovis BCG str. Tokyo 172 7561158 YP_002643537.1 CDS JTY_0473 NC_012207.1 555164 555457 D hypothetical protein 555164..555457 Mycobacterium bovis BCG str. Tokyo 172 7562852 YP_002643538.1 CDS JTY_0474 NC_012207.1 555461 556033 R hypothetical protein complement(555461..556033) Mycobacterium bovis BCG str. Tokyo 172 7561159 YP_002643539.1 CDS JTY_0475 NC_012207.1 556030 557454 R Differs from Rv0465c by 2aa, D36N, R106C, and from Mb0474c by 1aa, R326Q in BCG Pasteur and BCG Tokyo; transcriptional regulatory protein complement(556030..557454) Mycobacterium bovis BCG str. Tokyo 172 7561160 YP_002643540.1 CDS JTY_0476 NC_012207.1 557606 558400 D hypothetical protein 557606..558400 Mycobacterium bovis BCG str. Tokyo 172 7561161 YP_002643541.1 CDS icl NC_012207.1 558675 559961 D isocitrate lyase 558675..559961 Mycobacterium bovis BCG str. Tokyo 172 7561162 YP_002643542.1 CDS fadB2 NC_012207.1 560043 560903 D converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase 560043..560903 Mycobacterium bovis BCG str. Tokyo 172 7563341 YP_002643543.1 CDS umaA1 NC_012207.1 561036 561896 D mycolic acid synthase 561036..561896 Mycobacterium bovis BCG str. Tokyo 172 7562911 YP_002643544.1 CDS pcaA NC_012207.1 561996 562859 R Differs from Rv0470c, Mb0479c by 1aa, P154T in Mycobacterium bovis BCG Tokyo.; mycolic acid synthase complement(561996..562859) Mycobacterium bovis BCG str. Tokyo 172 7561657 YP_002643545.1 CDS JTY_0481 NC_012207.1 563002 563442 R hypothetical protein complement(563002..563442) Mycobacterium bovis BCG str. Tokyo 172 7562521 YP_002643546.1 CDS JTY_0482 NC_012207.1 563373 563861 R hypothetical protein complement(563373..563861) Mycobacterium bovis BCG str. Tokyo 172 7561163 YP_002643547.1 CDS JTY_0483 NC_012207.1 563871 564575 R Differs from Rv0472c and Mb0482c by 1aa, D162G in BCG Pasteur and BCG Tokyo; possibly TetR-family; transcriptional regulatory protein complement(563871..564575) Mycobacterium bovis BCG str. Tokyo 172 7561164 YP_002643548.1 CDS JTY_0484 NC_012207.1 564712 566082 D Differs from Rv0473 by 1aa, R5K in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 564712..566082 Mycobacterium bovis BCG str. Tokyo 172 7561165 YP_002643549.1 CDS JTY_0485 NC_012207.1 566169 566591 D transcriptional regulatory protein 566169..566591 Mycobacterium bovis BCG str. Tokyo 172 7561166 YP_002643550.1 CDS hbhA NC_012207.1 566945 567544 D heparin binding hemagglutinin 566945..567544 Mycobacterium bovis BCG str. Tokyo 172 7561167 YP_002643551.1 CDS JTY_0487 NC_012207.1 567656 567919 D transmembrane protein 567656..567919 Mycobacterium bovis BCG str. Tokyo 172 7563294 YP_002643552.1 CDS JTY_0488 NC_012207.1 567924 568370 D hypothetical protein 567924..568370 Mycobacterium bovis BCG str. Tokyo 172 7561168 YP_002643553.1 CDS deoC NC_012207.1 568370 569044 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 568370..569044 Mycobacterium bovis BCG str. Tokyo 172 7561169 YP_002643554.1 CDS JTY_0490 NC_012207.1 569069 570115 R hypothetical protein complement(569069..570115) Mycobacterium bovis BCG str. Tokyo 172 7561479 YP_002643555.1 CDS JTY_0491 NC_012207.1 570112 571047 R In Mycobacterium bovis, a 56 bp deletion results in a different NH2 part and leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (311 aa versus 340 aa); hypothetical protein complement(570112..571047) Mycobacterium bovis BCG str. Tokyo 172 7561170 YP_002643556.1 CDS JTY_0492 NC_012207.1 571080 571604 R hypothetical protein complement(571080..571604) Mycobacterium bovis BCG str. Tokyo 172 7561171 YP_002643557.1 CDS murB NC_012207.1 571631 572740 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 571631..572740 Mycobacterium bovis BCG str. Tokyo 172 7561172 YP_002643558.1 CDS lprQ NC_012207.1 572802 574157 D lipoprotein 572802..574157 Mycobacterium bovis BCG str. Tokyo 172 7563572 YP_002643559.1 CDS JTY_0495 NC_012207.1 574138 574893 R Differs from Rv0484c by 1aa, L140I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; short-chain type oxidoreductase complement(574138..574893) Mycobacterium bovis BCG str. Tokyo 172 7560534 YP_002643560.1 CDS JTY_0496 NC_012207.1 575076 576392 D transcriptional regulatory protein 575076..576392 Mycobacterium bovis BCG str. Tokyo 172 7561173 YP_002643561.1 CDS JTY_0497 NC_012207.1 576440 577882 D mannosyltransferase 576440..577882 Mycobacterium bovis BCG str. Tokyo 172 7561174 YP_002643562.1 CDS JTY_0498 NC_012207.1 577879 578430 D hypothetical protein 577879..578430 Mycobacterium bovis BCG str. Tokyo 172 7561175 YP_002643563.1 CDS JTY_0499 NC_012207.1 578814 579419 D integral membrane protein 578814..579419 Mycobacterium bovis BCG str. Tokyo 172 7561176 YP_002643564.1 CDS gpmA NC_012207.1 579576 580325 D 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 579576..580325 Mycobacterium bovis BCG str. Tokyo 172 7561177 YP_002643565.1 CDS senX3 NC_012207.1 580499 581731 D Differs from Rv0490 and Mb0500 by 1aa, S109F; two component sensor histidine kinase 580499..581731 Mycobacterium bovis BCG str. Tokyo 172 7563275 YP_002643566.1 CDS regX3 NC_012207.1 581959 582642 D Differs from Rv0491 and Mb0501 by 1aa, T18A in BCG Pasteur, by 2aa, T18A, C219R in BCG Tokyo.; probably LuxR-family; two component sensory transduction protein 581959..582642 Mycobacterium bovis BCG str. Tokyo 172 7560778 YP_002643567.1 CDS JTY_0503 NC_012207.1 582639 584528 R Differs from Rv0492c by 1aa, F520L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase GMC-type complement(582639..584528) Mycobacterium bovis BCG str. Tokyo 172 7561564 YP_002643568.1 CDS JTY_0504 NC_012207.1 584525 584854 R hypothetical protein complement(584525..584854) Mycobacterium bovis BCG str. Tokyo 172 7561178 YP_002643569.1 CDS JTY_0505 NC_012207.1 584851 585840 R Differs from Rv0493c by 1aa, G174S in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein complement(584851..585840) Mycobacterium bovis BCG str. Tokyo 172 7561179 YP_002643570.1 CDS JTY_0506 NC_012207.1 585845 586573 D probably GntR-family; transcriptional regulatory protein 585845..586573 Mycobacterium bovis BCG str. Tokyo 172 7561180 YP_002643571.1 CDS JTY_0507 NC_012207.1 586574 587464 R hypothetical protein complement(586574..587464) Mycobacterium bovis BCG str. Tokyo 172 7561181 YP_002643572.1 CDS JTY_0508 NC_012207.1 587544 588530 D hypothetical protein 587544..588530 Mycobacterium bovis BCG str. Tokyo 172 7561182 YP_002643573.1 CDS JTY_0509 NC_012207.1 588527 589459 D transmembrane protein 588527..589459 Mycobacterium bovis BCG str. Tokyo 172 7561183 YP_002643574.1 CDS JTY_0510 NC_012207.1 589475 590317 D hypothetical protein 589475..590317 Mycobacterium bovis BCG str. Tokyo 172 7561184 YP_002643575.1 CDS JTY_0511 NC_012207.1 590333 591208 D hypothetical protein 590333..591208 Mycobacterium bovis BCG str. Tokyo 172 7561185 YP_002643576.1 CDS proC NC_012207.1 591233 592120 D catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 591233..592120 Mycobacterium bovis BCG str. Tokyo 172 7561186 YP_002643577.1 CDS JTY_0513 NC_012207.1 592261 592497 D hypothetical protein 592261..592497 Mycobacterium bovis BCG str. Tokyo 172 7560826 YP_002643578.1 CDS galE2 NC_012207.1 592804 593934 D UDP-glucose 4-epimerase 592804..593934 Mycobacterium bovis BCG str. Tokyo 172 7561187 YP_002643579.1 CDS JTY_0515 NC_012207.1 593941 595017 D hypothetical protein 593941..595017 Mycobacterium bovis BCG str. Tokyo 172 7561897 YP_002643580.1 CDS cmaA2 NC_012207.1 595021 595929 R cyclopropane-fatty-acyl-phospholipid synthase 2 complement(595021..595929) Mycobacterium bovis BCG str. Tokyo 172 7561188 YP_002643581.1 CDS JTY_0517 NC_012207.1 595952 596452 R hypothetical protein complement(595952..596452) Mycobacterium bovis BCG str. Tokyo 172 7562115 YP_002643582.1 CDS serB1 NC_012207.1 596614 597735 R phosphoserine phosphatase complement(596614..597735) Mycobacterium bovis BCG str. Tokyo 172 7561189 YP_002643583.1 CDS mmpS2 NC_012207.1 597909 598352 D hypothetical protein 597909..598352 Mycobacterium bovis BCG str. Tokyo 172 7560781 YP_002643584.1 CDS mmpL2 NC_012207.1 598349 601255 D Differs from Mb0519 by 1aa, D119H, and from Rv0507 by 3aa, H426R, Y509D, C722S in BCG Pasteur and BCG Tokyo; transmembrane transport protein 598349..601255 Mycobacterium bovis BCG str. Tokyo 172 7563512 YP_002643585.1 CDS JTY_0521 NC_012207.1 601248 601541 D hypothetical protein 601248..601541 Mycobacterium bovis BCG str. Tokyo 172 7564487 YP_002643586.1 CDS hemA NC_012207.1 601591 602997 D catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 601591..602997 Mycobacterium bovis BCG str. Tokyo 172 7561190 YP_002643587.1 CDS hemC NC_012207.1 603007 603936 D transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 603007..603936 Mycobacterium bovis BCG str. Tokyo 172 7563297 YP_002643588.1 CDS hemD NC_012207.1 603969 605666 D uroporphyrin-III C-methyltransferase 603969..605666 Mycobacterium bovis BCG str. Tokyo 172 7563299 YP_002643589.1 CDS hemB NC_012207.1 605752 606741 D catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 605752..606741 Mycobacterium bovis BCG str. Tokyo 172 7563300 YP_002643590.1 CDS JTY_0526 NC_012207.1 606754 607302 D transmembrane protein 606754..607302 Mycobacterium bovis BCG str. Tokyo 172 7563298 YP_002643591.1 CDS JTY_0527 NC_012207.1 607299 607598 D Differs from Mb0527 and Rv0514 by 1aa, G23A in BCG Pasteur and BCG Tokyo; transmembrane protein 607299..607598 Mycobacterium bovis BCG str. Tokyo 172 7561191 YP_002643592.1 CDS JTY_0528 NC_012207.1 607701 609212 D conserved 13E12 repeat family protein 607701..609212 Mycobacterium bovis BCG str. Tokyo 172 7561192 YP_002643593.1 CDS JTY_0529 NC_012207.1 609209 609685 R hypothetical protein complement(609209..609685) Mycobacterium bovis BCG str. Tokyo 172 7561193 YP_002643594.1 CDS JTY_0530 NC_012207.1 609896 611206 D Differs from Rv0517 by 1aa, G394D in BCG Pasteur and BCG Tokyo; membrane acyltransferase 609896..611206 Mycobacterium bovis BCG str. Tokyo 172 7561194 YP_002643595.1 CDS JTY_0531 NC_012207.1 611338 612033 D hypothetical protein 611338..612033 Mycobacterium bovis BCG str. Tokyo 172 7561195 YP_002643596.1 CDS JTY_0532 NC_012207.1 612322 613224 R hypothetical protein complement(612322..613224) Mycobacterium bovis BCG str. Tokyo 172 7561196 YP_002643597.1 CDS JTY_0533 NC_012207.1 613405 613755 D methyltransferase/methylase 613405..613755 Mycobacterium bovis BCG str. Tokyo 172 7561197 YP_002643598.1 CDS JTY_0534 NC_012207.1 613748 614053 D methyltransferase/methylase 613748..614053 Mycobacterium bovis BCG str. Tokyo 172 7561198 YP_002643599.1 CDS gabP NC_012207.1 614188 615492 D 4-amino butyrate transport carrier; GabA permease 614188..615492 Mycobacterium bovis BCG str. Tokyo 172 7561199 YP_002643600.1 CDS JTY_0536 NC_012207.1 615476 615871 R hypothetical protein complement(615476..615871) Mycobacterium bovis BCG str. Tokyo 172 7561893 YP_002643601.1 CDS hemL NC_012207.1 615985 617373 D Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 615985..617373 Mycobacterium bovis BCG str. Tokyo 172 7561200 YP_002643602.1 CDS JTY_0538 NC_012207.1 617373 617981 D hypothetical protein 617373..617981 Mycobacterium bovis BCG str. Tokyo 172 7563303 YP_002643603.1 CDS JTY_0539 NC_012207.1 617996 618646 D thioredoxin protein 617996..618646 Mycobacterium bovis BCG str. Tokyo 172 7561201 YP_002643604.1 CDS ccdA NC_012207.1 618643 619422 D cytochrome c-type biogenesis protein 618643..619422 Mycobacterium bovis BCG str. Tokyo 172 7561202 YP_002643605.1 CDS JTY_0541 NC_012207.1 619455 621044 D transmembrane protein 619455..621044 Mycobacterium bovis BCG str. Tokyo 172 7562085 YP_002643606.1 CDS ccsA NC_012207.1 621041 622015 D cytochrome c-type biogenesis protein 621041..622015 Mycobacterium bovis BCG str. Tokyo 172 7561203 YP_002643607.1 CDS JTY_0543 NC_012207.1 622057 623274 D hypothetical protein 622057..623274 Mycobacterium bovis BCG str. Tokyo 172 7562086 YP_002643608.1 CDS JTY_0544 NC_012207.1 623479 623796 D hypothetical protein 623479..623796 Mycobacterium bovis BCG str. Tokyo 172 7564086 YP_002643609.1 CDS PE_PGRS6a NC_012207.1 623943 625688 D In Mycobacterium tuberculosis strain H37Rv, PE_PGRS6 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-T) splits PE_PGRS6 into 2 parts, PE_PGRS6a and PE_PGRS6b, resulting in PE_PGRS6a having a different COOH part. There is also a 84 bp and a 9 bp (*-cggggccgg) insertion in PE_PGRS6a; PE-PGRS family protein 623943..625688 Mycobacterium bovis BCG str. Tokyo 172 7564087 YP_002643610.1 CDS fabH NC_012207.1 625717 626724 R FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase complement(625717..626724) Mycobacterium bovis BCG str. Tokyo 172 7562391 YP_002643611.1 CDS menA NC_012207.1 626806 627684 R catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase complement(626806..627684) Mycobacterium bovis BCG str. Tokyo 172 7562903 YP_002643612.1 CDS pnp NC_012207.1 627701 628495 D Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate; 5'-methylthioadenosine phosphorylase 627701..628495 Mycobacterium bovis BCG str. Tokyo 172 7564449 YP_002643613.1 CDS galE3 NC_012207.1 628492 629532 D UDP-glucose 4-epimerase 628492..629532 Mycobacterium bovis BCG str. Tokyo 172 7562135 YP_002643614.1 CDS JTY_0551 NC_012207.1 629542 630975 R integral membrane protein complement(629542..630975) Mycobacterium bovis BCG str. Tokyo 172 7561898 YP_002643615.1 CDS JTY_0552 NC_012207.1 631284 632930 D Differs from Rv0538 by 1aa, P228R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 631284..632930 Mycobacterium bovis BCG str. Tokyo 172 7564088 YP_002643616.1 CDS JTY_0553 NC_012207.1 632987 633619 D dolichyl-phosphate sugar synthase 632987..633619 Mycobacterium bovis BCG str. Tokyo 172 7564089 YP_002643617.1 CDS JTY_0554 NC_012207.1 633616 634278 D hypothetical protein 633616..634278 Mycobacterium bovis BCG str. Tokyo 172 7564090 YP_002643618.1 CDS JTY_0555 NC_012207.1 634299 635648 R Differs from Rv0541c by 1aa, V226I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein complement(634299..635648) Mycobacterium bovis BCG str. Tokyo 172 7564091 YP_002643619.1 CDS menE NC_012207.1 635660 636748 R O-succinylbenzoic acid--CoA ligase complement(635660..636748) Mycobacterium bovis BCG str. Tokyo 172 7564092 YP_002643620.1 CDS JTY_0557 NC_012207.1 636817 637119 R hypothetical protein complement(636817..637119) Mycobacterium bovis BCG str. Tokyo 172 7564453 YP_002643621.1 CDS JTY_0558 NC_012207.1 637179 637457 R transmembrane protein complement(637179..637457) Mycobacterium bovis BCG str. Tokyo 172 7564093 YP_002643622.1 CDS pitA NC_012207.1 637454 638707 R Differs from Rv0545c by 1aa, S49P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; low-affinity inorganic phosphate transporter integral membrane protein complement(637454..638707) Mycobacterium bovis BCG str. Tokyo 172 7564094 YP_002643623.1 CDS JTY_0560 NC_012207.1 638827 639213 R hypothetical protein complement(638827..639213) Mycobacterium bovis BCG str. Tokyo 172 7562426 YP_002643624.1 CDS JTY_0561 NC_012207.1 639276 640160 R short chain dehydrogenase complement(639276..640160) Mycobacterium bovis BCG str. Tokyo 172 7564095 YP_002643625.1 CDS menB NC_012207.1 640256 641200 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(640256..641200) Mycobacterium bovis BCG str. Tokyo 172 7564096 YP_002643626.1 CDS JTY_0564 NC_012207.1 641576 641884 R In Mycobacterium tuberculosis strain H37Rv, Rv0549c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (T-*), splits Rv0549c into 2 parts; hypothetical protein complement(641576..641884) Mycobacterium bovis BCG str. Tokyo 172 7564097 YP_002643627.1 CDS JTY_0565 NC_012207.1 641881 642147 R hypothetical protein complement(641881..642147) Mycobacterium bovis BCG str. Tokyo 172 7564098 YP_002643628.1 CDS fadD8 NC_012207.1 642339 644054 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(642339..644054) Mycobacterium bovis BCG str. Tokyo 172 7564099 YP_002643629.1 CDS JTY_0567 NC_012207.1 644132 645736 D Differs from Rv0552 and Mb0567 by 1aa, T144I in Mycobacterium bovis BCG Pasteur; hypothetical protein 644132..645736 Mycobacterium bovis BCG str. Tokyo 172 7563356 YP_002643630.1 CDS menC NC_012207.1 645733 646713 D catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 645733..646713 Mycobacterium bovis BCG str. Tokyo 172 7564100 YP_002643631.1 CDS bpoC NC_012207.1 646710 647498 D non-haem peroxidase; peroxidase 646710..647498 Mycobacterium bovis BCG str. Tokyo 172 7564451 YP_002643632.1 CDS menD NC_012207.1 647541 649205 D SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 647541..649205 Mycobacterium bovis BCG str. Tokyo 172 7562078 YP_002643633.1 CDS JTY_0571 NC_012207.1 649202 649717 D Differs from Rv0556 by 1aa, R15L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 649202..649717 Mycobacterium bovis BCG str. Tokyo 172 7564452 YP_002643634.1 CDS pimB NC_012207.1 649779 650915 D mannosyltransferase 649779..650915 Mycobacterium bovis BCG str. Tokyo 172 7564101 YP_002643635.1 CDS ubiE NC_012207.1 650932 651636 D Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 650932..651636 Mycobacterium bovis BCG str. Tokyo 172 7562422 YP_002643636.1 CDS JTY_0574 NC_012207.1 651650 651988 R hypothetical protein complement(651650..651988) Mycobacterium bovis BCG str. Tokyo 172 7561649 YP_002643637.1 CDS JTY_0575 NC_012207.1 652022 652747 R benzoquinone methyltransferase complement(652022..652747) Mycobacterium bovis BCG str. Tokyo 172 7564102 YP_002643638.1 CDS JTY_0576 NC_012207.1 652772 653998 R oxidoreductase complement(652772..653998) Mycobacterium bovis BCG str. Tokyo 172 7564103 YP_002643639.1 CDS grcC1 NC_012207.1 654014 655021 D polyprenyl-diphosphate synthase 654014..655021 Mycobacterium bovis BCG str. Tokyo 172 7564104 YP_002643640.1 CDS htpX NC_012207.1 655122 655982 D metalloprotease; heat shock protein HtpX 655122..655982 Mycobacterium bovis BCG str. Tokyo 172 7563279 YP_002643641.1 CDS gpdA1 NC_012207.1 656167 657192 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(656167..657192) Mycobacterium bovis BCG str. Tokyo 172 7563332 YP_002643642.1 CDS JTY_0580 NC_012207.1 657253 658713 R monooxygenase complement(657253..658713) Mycobacterium bovis BCG str. Tokyo 172 7563274 YP_002643643.1 CDS JTY_0581 NC_012207.1 658791 659282 R nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein complement(658791..659282) Mycobacterium bovis BCG str. Tokyo 172 7564105 YP_002643644.1 CDS JTY_0582 NC_012207.1 659564 660583 D Differs from Rv0567 by 1aa, L201F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methyltransferase/methylase 659564..660583 Mycobacterium bovis BCG str. Tokyo 172 7561648 YP_002643645.1 CDS cyp135B1 NC_012207.1 660693 662111 D Differs from Rv0568 and Mb0583 by 1aa, E120G in BCG Pasteur and BCG Tokyo; cytochrome p450 135b1 660693..662111 Mycobacterium bovis BCG str. Tokyo 172 7564107 YP_002643646.1 CDS JTY_0584 NC_012207.1 662246 662512 D hypothetical protein 662246..662512 Mycobacterium bovis BCG str. Tokyo 172 7563161 YP_002643647.1 CDS nrdZ NC_012207.1 662538 664670 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (C-*) leads to a product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; ribonucleoside-diphosphate reductase large subunit 662538..664670 Mycobacterium bovis BCG str. Tokyo 172 7564108 YP_002643648.1 CDS JTY_0586 NC_012207.1 664729 666060 R Differs from Rv0571c and Mb0586c by 1aa, L258F in BCG Pasteur and BCG Tokyo; hypothetical protein complement(664729..666060) Mycobacterium bovis BCG str. Tokyo 172 7562470 YP_002643649.1 CDS JTY_0587 NC_012207.1 666284 666625 R Differs from Rv0572c by 1aa, L31F in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(666284..666625) Mycobacterium bovis BCG str. Tokyo 172 7564109 YP_002643650.1 CDS JTY_0588 NC_012207.1 667093 668484 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(667093..668484) Mycobacterium bovis BCG str. Tokyo 172 7564110 YP_002643651.1 CDS JTY_0589 NC_012207.1 668494 669636 R Differs from Rv0574c by 1aa, K4N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(668494..669636) Mycobacterium bovis BCG str. Tokyo 172 7564111 YP_002643652.1 CDS JTY_0590 NC_012207.1 669852 670988 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-C) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; hypothetical protein complement(669852..670988) Mycobacterium bovis BCG str. Tokyo 172 7564112 YP_002643653.1 CDS JTY_0591 NC_012207.1 671091 672395 D Differs from Rv0576 by 1aa, H233R in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; possibly ArsR-family; transcriptional regulatory protein 671091..672395 Mycobacterium bovis BCG str. Tokyo 172 7564113 YP_002643654.1 CDS TB27.3 NC_012207.1 672409 673194 D hypothetical protein 672409..673194 Mycobacterium bovis BCG str. Tokyo 172 7564114 YP_002643655.1 CDS PE_PGRS7 NC_012207.1 673239 677159 R Differs from Rv0578c and from Mb0593c by 3aa, there are deleted in Mycobacterium bovis BCG Pasteur.; PE-PGRS family protein complement(673239..677159) Mycobacterium bovis BCG str. Tokyo 172 7561833 YP_002643656.1 CDS JTY_0594 NC_012207.1 677481 678239 D hypothetical protein 677481..678239 Mycobacterium bovis BCG str. Tokyo 172 7562392 YP_002643657.1 CDS JTY_0595 NC_012207.1 678368 678859 R hypothetical protein complement(678368..678859) Mycobacterium bovis BCG str. Tokyo 172 7564115 YP_002643658.1 CDS JTY_0596 NC_012207.1 678953 679168 D hypothetical protein 678953..679168 Mycobacterium bovis BCG str. Tokyo 172 7564116 YP_002643659.1 CDS JTY_0597 NC_012207.1 679165 679572 D hypothetical protein 679165..679572 Mycobacterium bovis BCG str. Tokyo 172 7564117 YP_002643660.1 CDS lpqN NC_012207.1 679632 680318 R lipoprotein complement(679632..680318) Mycobacterium bovis BCG str. Tokyo 172 7564118 YP_002643661.1 CDS JTY_0599 NC_012207.1 680472 683105 D Differs from Rv0584 by 1aa G90D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 680472..683105 Mycobacterium bovis BCG str. Tokyo 172 7560506 YP_002643662.1 CDS JTY_0600 NC_012207.1 683128 685515 R Differs from Rv0585c by 1aa V438I and from Mb0600c by 2aa M150I and V438I in BCG Pasteur and BCG Tokyo; integral membrane protein complement(683128..685515) Mycobacterium bovis BCG str. Tokyo 172 7564119 YP_002643663.1 CDS JTY_0601 NC_012207.1 685653 686375 D GntR-family; transcriptional regulatory protein 685653..686375 Mycobacterium bovis BCG str. Tokyo 172 7564120 YP_002643664.1 CDS yrbE2A NC_012207.1 686372 687169 D hypothetical protein 686372..687169 Mycobacterium bovis BCG str. Tokyo 172 7564121 YP_002643665.1 CDS yrbE2B NC_012207.1 687171 688058 D hypothetical protein 687171..688058 Mycobacterium bovis BCG str. Tokyo 172 7561452 YP_002643666.1 CDS mce2A NC_012207.1 688064 689278 D Differs from Rv0589 by 1aa S51F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; MCE-family protein 688064..689278 Mycobacterium bovis BCG str. Tokyo 172 7561453 YP_002643667.1 CDS mce2B NC_012207.1 689275 690306 D In Mycobacterium tuberculosis strain H37Rv, mce2B and Rv0590A are 2 genes, most likely to be linked. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, an in-frame insertion of a single base (*-G) leads to a single product; MCE-family protein 689275..690306 Mycobacterium bovis BCG str. Tokyo 172 7564437 YP_002643668.1 CDS mce2C NC_012207.1 690303 691748 D Differs from Rv0591 by 2aa M49T and N398T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; MCE-family protein 690303..691748 Mycobacterium bovis BCG str. Tokyo 172 7564438 YP_002643669.1 CDS mce2Da NC_012207.1 691745 693295 D In Mycobacterium tuberculosis strain H37Rv, mce2D exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a frameshift occurs in a strech of C (7 for H37Rv, 8 for Mycobactrium bovis and 9 for Mycobacterium bovis BCG). This leads to mceDa genes with different COOH parts and a remnant mc2Db pseudogene; MCE-family protein 691745..693295 Mycobacterium bovis BCG str. Tokyo 172 7564439 YP_002643670.1 CDS lprL NC_012207.1 693270 694478 D In Mycobacterium bovis, a single base transition (C-T) introducing a stop codon, leads to the formation of a truncated product compared to its homolog in Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (188 aa versus 402 aa); MCE-family lipoprotein 693270..694478 Mycobacterium bovis BCG str. Tokyo 172 7564440 YP_002643671.1 CDS mce2F NC_012207.1 694483 696033 D MCE-family protein 694483..696033 Mycobacterium bovis BCG str. Tokyo 172 7560530 YP_002643672.1 CDS JTY_0610 NC_012207.1 696085 696477 R hypothetical protein complement(696085..696477) Mycobacterium bovis BCG str. Tokyo 172 7564441 YP_002643673.1 CDS JTY_0611 NC_012207.1 696474 696731 R hypothetical protein complement(696474..696731) Mycobacterium bovis BCG str. Tokyo 172 7564122 YP_002643674.1 CDS JTY_0612 NC_012207.1 696914 698149 R hypothetical protein complement(696914..698149) Mycobacterium bovis BCG str. Tokyo 172 7564123 YP_002643675.1 CDS JTY_0613 NC_012207.1 698400 698813 R hypothetical protein complement(698400..698813) Mycobacterium bovis BCG str. Tokyo 172 7564124 YP_002643676.1 CDS JTY_0614 NC_012207.1 698810 699046 R hypothetical protein complement(698810..699046) Mycobacterium bovis BCG str. Tokyo 172 7564125 YP_002643677.1 CDS JTY_0615 NC_012207.1 699150 699656 R two component sensor kinase complement(699150..699656) Mycobacterium bovis BCG str. Tokyo 172 7564126 YP_002643678.1 CDS JTY_0616 NC_012207.1 699770 700240 R first part; two component sensor kinase complement(699770..700240) Mycobacterium bovis BCG str. Tokyo 172 7564127 YP_002643679.1 CDS tcrA NC_012207.1 700284 701045 R Differs from Rv0602c by 1aa I28V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; two component DNA binding transcriptional regulatory protein complement(700284..701045) Mycobacterium bovis BCG str. Tokyo 172 7564128 YP_002643680.1 CDS JTY_0618 NC_012207.1 701102 701413 D Differs from Mb0619 by 2aa P77A and E96K in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; hypothetical protein 701102..701413 Mycobacterium bovis BCG str. Tokyo 172 7561838 YP_002643681.1 CDS lpqO NC_012207.1 701485 702435 D Differs from Rv0604 by 1aa P180S in BCG Pasteur and BCG Tokyo; lipoprotein 701485..702435 Mycobacterium bovis BCG str. Tokyo 172 7564129 YP_002643682.1 CDS JTY_0620 NC_012207.1 702652 703260 D resolvase 702652..703260 Mycobacterium bovis BCG str. Tokyo 172 7560507 YP_002643683.1 CDS JTY_0621 NC_012207.1 703262 704005 D transposase 703262..704005 Mycobacterium bovis BCG str. Tokyo 172 7564130 YP_002643684.1 CDS JTY_0622 NC_012207.1 704059 704445 D hypothetical protein 704059..704445 Mycobacterium bovis BCG str. Tokyo 172 7564131 YP_002643685.1 CDS JTY_0623 NC_012207.1 704490 704735 D hypothetical protein 704490..704735 Mycobacterium bovis BCG str. Tokyo 172 7564132 YP_002643686.1 CDS JTY_0624 NC_012207.1 704732 705133 D hypothetical protein 704732..705133 Mycobacterium bovis BCG str. Tokyo 172 7564133 YP_002643687.1 CDS JTY_0625 NC_012207.1 705076 705303 D hypothetical protein 705076..705303 Mycobacterium bovis BCG str. Tokyo 172 7564134 YP_002643688.1 CDS JTY_0626 NC_012207.1 705998 707155 R Differs from Rv0610c by 1aa S103N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(705998..707155) Mycobacterium bovis BCG str. Tokyo 172 7564135 YP_002643689.1 CDS JTY_0627 NC_012207.1 707207 707590 R hypothetical protein complement(707207..707590) Mycobacterium bovis BCG str. Tokyo 172 7564136 YP_002643690.1 CDS JTY_0628 NC_012207.1 707570 708175 D hypothetical protein 707570..708175 Mycobacterium bovis BCG str. Tokyo 172 7564137 YP_002643691.1 CDS JTY_0629 NC_012207.1 708194 710761 R hypothetical protein complement(708194..710761) Mycobacterium bovis BCG str. Tokyo 172 7564138 YP_002643692.1 CDS JTY_0630 NC_012207.1 710602 711594 D hypothetical protein 710602..711594 Mycobacterium bovis BCG str. Tokyo 172 7564139 YP_002643693.1 CDS JTY_0631 NC_012207.1 711591 711833 D integral membrane protein 711591..711833 Mycobacterium bovis BCG str. Tokyo 172 7564140 YP_002643694.1 CDS JTY_0632 NC_012207.1 711830 712096 R hypothetical protein complement(711830..712096) Mycobacterium bovis BCG str. Tokyo 172 7564141 YP_002643695.1 CDS JTY_0633 NC_012207.1 712028 712255 D antitoxin 712028..712255 Mycobacterium bovis BCG str. Tokyo 172 7564142 YP_002643696.1 CDS JTY_0634 NC_012207.1 712252 712653 D hypothetical protein 712252..712653 Mycobacterium bovis BCG str. Tokyo 172 7564143 YP_002643697.1 CDS galT NC_012207.1 712782 713966 D In Mycobacterium tuberculosis strain H37Rv, galT is split into 2 parts, galT' and 'galT. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, an in-frame insertion of a single base (*-A) leads to a single product. Differs from Mb0635 by 1aa R183G and from Rv0619 by 1aa A397T in BCG Pasteur and BCG Tokyo; galactose-1-phosphate uridylyltransferase 712782..713966 Mycobacterium bovis BCG str. Tokyo 172 7564144 YP_002643698.1 CDS galK NC_012207.1 713963 715054 D catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 713963..715054 Mycobacterium bovis BCG str. Tokyo 172 7561900 YP_002643699.1 CDS JTY_0637 NC_012207.1 715449 716606 D In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (A-G) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (385 aa versus 354 aa); hypothetical protein 715449..716606 Mycobacterium bovis BCG str. Tokyo 172 7561899 YP_002643700.1 CDS JTY_0638 NC_012207.1 716617 717564 D hypothetical protein 716617..717564 Mycobacterium bovis BCG str. Tokyo 172 7564145 YP_002643701.1 CDS JTY_0639 NC_012207.1 717657 717911 D hypothetical protein 717657..717911 Mycobacterium bovis BCG str. Tokyo 172 7564146 YP_002643702.1 CDS JTY_0640 NC_012207.1 717911 718306 D hypothetical protein 717911..718306 Mycobacterium bovis BCG str. Tokyo 172 7564147 YP_002643703.1 CDS JTY_0641 NC_012207.1 718400 719140 R transmembrane protein complement(718400..719140) Mycobacterium bovis BCG str. Tokyo 172 7564148 YP_002643704.1 CDS JTY_0642 NC_012207.1 719272 719532 D hypothetical protein 719272..719532 Mycobacterium bovis BCG str. Tokyo 172 7564149 YP_002643705.1 CDS JTY_0643 NC_012207.1 719529 719936 D hypothetical protein 719529..719936 Mycobacterium bovis BCG str. Tokyo 172 7564150 YP_002643706.1 CDS JTY_0644 NC_012207.1 720008 721159 R hypothetical protein complement(720008..721159) Mycobacterium bovis BCG str. Tokyo 172 7564151 YP_002643707.1 CDS recD NC_012207.1 721252 722979 R Differs from Rv0629c by 1aa A536T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; exonuclease V alpha chain complement(721252..722979) Mycobacterium bovis BCG str. Tokyo 172 7564152 YP_002643708.1 CDS recBa NC_012207.1 723566 726259 R In Mycobacterium tuberculosis strain H37Rv, recB exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (G-*) splits recB into 2 parts, recBa and recBb. Differs from Mb0647c by 1aa H514R and from Rv0630c by 3aa L74V, H514R and F811V in BCG Pasteur and BCG Tokyo; exonuclease V subunit beta complement(723566..726259) Mycobacterium bovis BCG str. Tokyo 172 7561555 YP_002643709.1 CDS recC NC_012207.1 726259 729552 R Differs from Rv0631c by 1aa E329G and from Mb0648c by 1aa P858L in BCG Pasteur and BCG Tokyo; exonuclease V gamma chain complement(726259..729552) Mycobacterium bovis BCG str. Tokyo 172 7561554 YP_002643710.1 CDS echA3 NC_012207.1 729829 730524 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(729829..730524) Mycobacterium bovis BCG str. Tokyo 172 7561556 YP_002643711.1 CDS JTY_0650 NC_012207.1 730573 731403 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 9 bp deletion (CGGGTGCGC-*) leads to shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (Rv0633c) (276 aa versus 279 aa); hypothetical protein complement(730573..731403) Mycobacterium bovis BCG str. Tokyo 172 7561534 YP_002643712.1 CDS JTY_0651 NC_012207.1 731557 732270 R glyoxalase II complement(731557..732270) Mycobacterium bovis BCG str. Tokyo 172 7564153 YP_002643713.1 CDS JTY_0652 NC_012207.1 732350 732601 D hypothetical protein 732350..732601 Mycobacterium bovis BCG str. Tokyo 172 7564154 YP_002643714.1 CDS rpmG NC_012207.1 732949 733116 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 732949..733116 Mycobacterium bovis BCG str. Tokyo 172 7564464 YP_002643715.1 CDS JTY_0654 NC_012207.1 733167 733643 D functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadA 733167..733643 Mycobacterium bovis BCG str. Tokyo 172 7560721 YP_002643716.1 CDS JTY_0655 NC_012207.1 733630 734058 D functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadB 733630..734058 Mycobacterium bovis BCG str. Tokyo 172 7564156 YP_002643717.1 CDS JTY_0656 NC_012207.1 734062 734562 D functions as a heterodimer along with HadB in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; (3R)-hydroxyacyl-ACP dehydratase subunit HadC 734062..734562 Mycobacterium bovis BCG str. Tokyo 172 7564157 YP_002643718.1 CDS secE NC_012207.1 734974 735459 D forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 734974..735459 Mycobacterium bovis BCG str. Tokyo 172 7561635 YP_002643719.1 CDS nusG NC_012207.1 735491 736207 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 735491..736207 Mycobacterium bovis BCG str. Tokyo 172 7560773 YP_002643720.1 CDS rplK NC_012207.1 736259 736687 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 736259..736687 Mycobacterium bovis BCG str. Tokyo 172 7562490 YP_002643721.1 CDS rplA NC_012207.1 736754 737461 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 736754..737461 Mycobacterium bovis BCG str. Tokyo 172 7561611 YP_002643722.1 CDS mmaA4 NC_012207.1 737535 738440 R Differs from Rv0642c by 1aa L95F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methoxy mycolic acid synthase 4 complement(737535..738440) Mycobacterium bovis BCG str. Tokyo 172 7561603 YP_002643723.1 CDS mmaA3 NC_012207.1 738505 739386 R Differ from Rv0643c by 1aa, D98G in BCG Pasteur.; methoxy mycolic acid synthase 3 complement(738505..739386) Mycobacterium bovis BCG str. Tokyo 172 7564479 YP_002643724.1 CDS mmaA2 NC_012207.1 739534 740397 R Differs from Rv0644c by 1aa L114R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methoxy mycolic acid synthase 2 complement(739534..740397) Mycobacterium bovis BCG str. Tokyo 172 7564478 YP_002643725.1 CDS mmaA1 NC_012207.1 740564 741424 R methoxy mycolic acid synthase 1 complement(740564..741424) Mycobacterium bovis BCG str. Tokyo 172 7564477 YP_002643726.1 CDS lipG NC_012207.1 741471 742376 R lipase/esterase complement(741471..742376) Mycobacterium bovis BCG str. Tokyo 172 7564476 YP_002643727.1 CDS JTY_0666 NC_012207.1 742388 743854 R Differs from Rv0647c by 1aa T293A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(742388..743854) Mycobacterium bovis BCG str. Tokyo 172 7562835 YP_002643728.1 CDS JTY_0667 NC_012207.1 743940 748136 D Differs from Rv0648 by 1aa L200S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; alpha-mannosidase 743940..748136 Mycobacterium bovis BCG str. Tokyo 172 7564159 YP_002643729.1 CDS fabD2 NC_012207.1 748133 748807 D malonyl CoA-acyl carrier protein transacylase 748133..748807 Mycobacterium bovis BCG str. Tokyo 172 7564160 YP_002643730.1 CDS JTY_0669 NC_012207.1 748807 749715 D sugar kinase 748807..749715 Mycobacterium bovis BCG str. Tokyo 172 7562895 YP_002643731.1 CDS rplJ NC_012207.1 750046 750582 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 750046..750582 Mycobacterium bovis BCG str. Tokyo 172 7564161 YP_002643732.1 CDS rplL NC_012207.1 750619 751011 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 750619..751011 Mycobacterium bovis BCG str. Tokyo 172 7561610 YP_002643733.1 CDS JTY_0672 NC_012207.1 751004 751699 R probably TetR-family; transcriptional regulatory protein complement(751004..751699) Mycobacterium bovis BCG str. Tokyo 172 7561612 YP_002643734.1 CDS JTY_0673 NC_012207.1 751770 753275 D dioxygenase 751770..753275 Mycobacterium bovis BCG str. Tokyo 172 7564162 YP_002643735.1 CDS mkl NC_012207.1 753287 754366 D ribonucleotide-transport ATP-binding protein ABC transporter 753287..754366 Mycobacterium bovis BCG str. Tokyo 172 7564163 YP_002643736.1 CDS JTY_0675 NC_012207.1 754754 755137 R hypothetical protein complement(754754..755137) Mycobacterium bovis BCG str. Tokyo 172 7564475 YP_002643737.1 CDS JTY_0676 NC_012207.1 755232 755387 R hypothetical protein complement(755232..755387) Mycobacterium bovis BCG str. Tokyo 172 7564164 YP_002643738.1 CDS JTY_0677 NC_012207.1 755463 756179 R Differs from Rv0658c by 1aa P75L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; integral membrane protein complement(755463..756179) Mycobacterium bovis BCG str. Tokyo 172 7564165 YP_002643739.1 CDS JTY_0678 NC_012207.1 756455 756763 R hypothetical protein complement(756455..756763) Mycobacterium bovis BCG str. Tokyo 172 7564166 YP_002643740.1 CDS JTY_0679 NC_012207.1 756750 756995 R hypothetical protein complement(756750..756995) Mycobacterium bovis BCG str. Tokyo 172 7564167 YP_002643741.1 CDS JTY_0680 NC_012207.1 757105 757542 R hypothetical protein complement(757105..757542) Mycobacterium bovis BCG str. Tokyo 172 7561040 YP_002643742.1 CDS JTY_0681 NC_012207.1 757539 757907 R hypothetical protein complement(757539..757907) Mycobacterium bovis BCG str. Tokyo 172 7561041 YP_002643743.1 CDS atsD NC_012207.1 757907 760270 D Differs from Rv0663 by 1aa G349D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; arylsulfatase 757907..760270 Mycobacterium bovis BCG str. Tokyo 172 7561042 YP_002643744.1 CDS JTY_0683 NC_012207.1 760302 760574 D hypothetical protein 760302..760574 Mycobacterium bovis BCG str. Tokyo 172 7562059 YP_002643745.1 CDS JTY_0684 NC_012207.1 760571 760909 D hypothetical protein 760571..760909 Mycobacterium bovis BCG str. Tokyo 172 7561043 YP_002643746.1 CDS JTY_0685 NC_012207.1 760906 761079 D hypothetical protein 760906..761079 Mycobacterium bovis BCG str. Tokyo 172 7561044 YP_002643747.1 CDS rpoB NC_012207.1 761577 765095 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 761577..765095 Mycobacterium bovis BCG str. Tokyo 172 7561045 YP_002643748.1 CDS rpoC NC_012207.1 765140 769090 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 765140..769090 Mycobacterium bovis BCG str. Tokyo 172 7560725 YP_002643749.1 CDS JTY_0688 NC_012207.1 769454 771367 R Differs from Rv0669c by 1aa P146S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrolase complement(769454..771367) Mycobacterium bovis BCG str. Tokyo 172 7560726 YP_002643750.1 CDS end NC_012207.1 771562 772320 D Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 771562..772320 Mycobacterium bovis BCG str. Tokyo 172 7561046 YP_002643751.1 CDS lpqP NC_012207.1 772352 773194 D lipoprotein 772352..773194 Mycobacterium bovis BCG str. Tokyo 172 7562863 YP_002643752.1 CDS fadE8 NC_012207.1 773254 774882 D acyl-CoA dehydrogenase 773254..774882 Mycobacterium bovis BCG str. Tokyo 172 7560508 YP_002643753.1 CDS echA4 NC_012207.1 774893 775831 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 774893..775831 Mycobacterium bovis BCG str. Tokyo 172 7563391 YP_002643754.1 CDS JTY_0693 NC_012207.1 775834 776556 D hypothetical protein 775834..776556 Mycobacterium bovis BCG str. Tokyo 172 7561535 YP_002643755.1 CDS echA5 NC_012207.1 776553 777344 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 776553..777344 Mycobacterium bovis BCG str. Tokyo 172 7561047 YP_002643756.1 CDS mmpL5 NC_012207.1 777356 780250 R Differs from Rv0676c by 2aa I794T and V948I in Mycobacterium bovis BCG Pasteur, by 3aa I794T, I906V, V948I in Mycobacterium bovis BCG Tokyo.; transmembrane transport protein complement(777356..780250) Mycobacterium bovis BCG str. Tokyo 172 7561536 YP_002643757.1 CDS mmpS5 NC_012207.1 780247 780675 R membrane protein mmpS5 complement(780247..780675) Mycobacterium bovis BCG str. Tokyo 172 7564490 YP_002643758.1 CDS JTY_0697 NC_012207.1 780760 781257 D hypothetical protein 780760..781257 Mycobacterium bovis BCG str. Tokyo 172 7563515 YP_002643759.1 CDS JTY_0698 NC_012207.1 781313 781810 R hypothetical threonine rich protein complement(781313..781810) Mycobacterium bovis BCG str. Tokyo 172 7561048 YP_002643760.1 CDS JTY_0699 NC_012207.1 781812 782186 R transmembrane protein complement(781812..782186) Mycobacterium bovis BCG str. Tokyo 172 7561049 YP_002643761.1 CDS JTY_0700 NC_012207.1 782491 783081 D possibly TetR-family; transcriptional regulatory protein 782491..783081 Mycobacterium bovis BCG str. Tokyo 172 7561050 YP_002643762.1 CDS rpsL NC_012207.1 783330 783704 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 783330..783704 Mycobacterium bovis BCG str. Tokyo 172 7561051 YP_002643763.1 CDS rpsG NC_012207.1 783704 784174 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 783704..784174 Mycobacterium bovis BCG str. Tokyo 172 7560739 YP_002643764.1 CDS fusA1 NC_012207.1 784255 786360 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 784255..786360 Mycobacterium bovis BCG str. Tokyo 172 7560734 YP_002643765.1 CDS tuf NC_012207.1 786591 787781 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 786591..787781 Mycobacterium bovis BCG str. Tokyo 172 7561888 YP_002643766.1 CDS JTY_0705 NC_012207.1 787919 788716 D Differs from Rv0686 by 1aa S82I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 787919..788716 Mycobacterium bovis BCG str. Tokyo 172 7561644 YP_002643767.1 CDS fabG NC_012207.1 788869 789696 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 788869..789696 Mycobacterium bovis BCG str. Tokyo 172 7561052 YP_002643768.1 CDS JTY_0707 NC_012207.1 789710 790930 D ferredoxin reductase 789710..790930 Mycobacterium bovis BCG str. Tokyo 172 7562896 YP_002643769.1 CDS JTY_0708 NC_012207.1 790927 791181 R hypothetical protein complement(790927..791181) Mycobacterium bovis BCG str. Tokyo 172 7561053 YP_002643770.1 CDS JTY_0709 NC_012207.1 791794 792843 R hypothetical protein complement(791794..792843) Mycobacterium bovis BCG str. Tokyo 172 7561054 YP_002643771.1 CDS JTY_0710 NC_012207.1 792840 793436 R transcriptional regulatory protein complement(792840..793436) Mycobacterium bovis BCG str. Tokyo 172 7561055 YP_002643772.1 CDS JTY_0711 NC_012207.1 793601 793930 D hypothetical protein 793601..793930 Mycobacterium bovis BCG str. Tokyo 172 7561056 YP_002643773.1 CDS pqqE NC_012207.1 793927 795102 D coenzyme pqq synthesis protein E 793927..795102 Mycobacterium bovis BCG str. Tokyo 172 7561057 YP_002643774.1 CDS lldD1 NC_012207.1 795105 796295 D cytochrome; L-lactate dehydrogenase 795105..796295 Mycobacterium bovis BCG str. Tokyo 172 7560817 YP_002643775.1 CDS JTY_0714 NC_012207.1 796485 797240 D hypothetical protein 796485..797240 Mycobacterium bovis BCG str. Tokyo 172 7562850 YP_002643776.1 CDS JTY_0715 NC_012207.1 797289 798701 D membrane sugar transferase 797289..798701 Mycobacterium bovis BCG str. Tokyo 172 7561058 YP_002643777.1 CDS JTY_0716 NC_012207.1 798703 800142 D dehydrogenase 798703..800142 Mycobacterium bovis BCG str. Tokyo 172 7561059 YP_002643778.1 CDS JTY_0717 NC_012207.1 800603 800932 D In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718; hypothetical protein 800603..800932 Mycobacterium bovis BCG str. Tokyo 172 7561060 YP_002643779.1 CDS JTY_0718 NC_012207.1 800980 801213 D In Mycobacterium tuberculosis strain H37Rv, Rv0698 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*) splits Rv0698 into 2 parts, Mb0717 and Mb0718; hypothetical protein 800980..801213 Mycobacterium bovis BCG str. Tokyo 172 7561061 YP_002643780.1 CDS JTY_0719 NC_012207.1 801398 801619 D hypothetical protein 801398..801619 Mycobacterium bovis BCG str. Tokyo 172 7561062 YP_002643781.1 CDS rpsJ NC_012207.1 802256 802561 D NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 802256..802561 Mycobacterium bovis BCG str. Tokyo 172 7561063 YP_002643782.1 CDS rplC NC_012207.1 802578 803231 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 802578..803231 Mycobacterium bovis BCG str. Tokyo 172 7560737 YP_002643783.1 CDS rplD NC_012207.1 803231 803902 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 803231..803902 Mycobacterium bovis BCG str. Tokyo 172 7561605 YP_002643784.1 CDS rplW NC_012207.1 803902 804204 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 803902..804204 Mycobacterium bovis BCG str. Tokyo 172 7561606 YP_002643785.1 CDS rplB NC_012207.1 804351 805193 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 804351..805193 Mycobacterium bovis BCG str. Tokyo 172 7561623 YP_002643786.1 CDS rpsS NC_012207.1 805234 805515 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 805234..805515 Mycobacterium bovis BCG str. Tokyo 172 7561604 YP_002643787.1 CDS rplV NC_012207.1 805512 806105 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 805512..806105 Mycobacterium bovis BCG str. Tokyo 172 7560748 YP_002643788.1 CDS rpsC NC_012207.1 806105 806929 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 806105..806929 Mycobacterium bovis BCG str. Tokyo 172 7561622 YP_002643789.1 CDS rplP NC_012207.1 806933 807349 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 806933..807349 Mycobacterium bovis BCG str. Tokyo 172 7560730 YP_002643790.1 CDS rpmC NC_012207.1 807349 807582 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 807349..807582 Mycobacterium bovis BCG str. Tokyo 172 7561616 YP_002643791.1 CDS rpsQ NC_012207.1 807579 807989 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 807579..807989 Mycobacterium bovis BCG str. Tokyo 172 7560716 YP_002643792.1 CDS atsA NC_012207.1 808158 810521 D In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, atsA exists as a single gene. In Mycobacterium bovis, a single base transversion (G-T), introducing a stop codon, splits atsA into 2 parts, atsAa and atsAb; arylsulfatase 808158..810521 Mycobacterium bovis BCG str. Tokyo 172 7560745 YP_002643793.1 CDS JTY_0732 NC_012207.1 810569 811468 D hypothetical protein 810569..811468 Mycobacterium bovis BCG str. Tokyo 172 7562055 YP_002643794.1 CDS JTY_0733 NC_012207.1 811769 812710 D transmembrane protein 811769..812710 Mycobacterium bovis BCG str. Tokyo 172 7561064 YP_002643795.1 CDS rplN NC_012207.1 813196 813564 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 813196..813564 Mycobacterium bovis BCG str. Tokyo 172 7561065 YP_002643796.1 CDS rplX NC_012207.1 813565 813882 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 813565..813882 Mycobacterium bovis BCG str. Tokyo 172 7561614 YP_002643797.1 CDS rplE NC_012207.1 813882 814445 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 813882..814445 Mycobacterium bovis BCG str. Tokyo 172 7561624 YP_002643798.1 CDS rpsN NC_012207.1 814450 814635 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 814450..814635 Mycobacterium bovis BCG str. Tokyo 172 7561607 YP_002643799.1 CDS rpsH NC_012207.1 814799 815197 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 814799..815197 Mycobacterium bovis BCG str. Tokyo 172 7560741 YP_002643800.1 CDS rplF NC_012207.1 815221 815760 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 815221..815760 Mycobacterium bovis BCG str. Tokyo 172 7560735 YP_002643801.1 CDS rplR NC_012207.1 815763 816131 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 815763..816131 Mycobacterium bovis BCG str. Tokyo 172 7561608 YP_002643802.1 CDS rpsE NC_012207.1 816151 816813 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 816151..816813 Mycobacterium bovis BCG str. Tokyo 172 7561618 YP_002643803.1 CDS rpmD NC_012207.1 816816 817013 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 816816..817013 Mycobacterium bovis BCG str. Tokyo 172 7560732 YP_002643804.1 CDS rplO NC_012207.1 817013 817453 D late assembly protein; 50S ribosomal protein L15 817013..817453 Mycobacterium bovis BCG str. Tokyo 172 7560717 YP_002643805.1 CDS sppA NC_012207.1 817486 819357 D endopeptidase IV; protease IV 817486..819357 Mycobacterium bovis BCG str. Tokyo 172 7561615 YP_002643806.1 CDS JTY_0745 NC_012207.1 819362 820267 R hypothetical protein complement(819362..820267) Mycobacterium bovis BCG str. Tokyo 172 7561806 YP_002643807.1 CDS JTY_0746 NC_012207.1 820360 821463 R hypothetical protein complement(820360..821463) Mycobacterium bovis BCG str. Tokyo 172 7561066 YP_002643808.1 CDS fucA NC_012207.1 821666 822322 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose-phosphate aldolase complement(821666..822322) Mycobacterium bovis BCG str. Tokyo 172 7561067 YP_002643809.1 CDS serA2 NC_012207.1 822319 823299 R Differs from Rv0728c by 1aa H242R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; D-3-phosphoglycerate dehydrogenase complement(822319..823299) Mycobacterium bovis BCG str. Tokyo 172 7561884 YP_002643810.1 CDS xylB NC_012207.1 823330 824676 D Differs from Rv0729 by 2aa P134L and S439 in Mycobacterium bovis BCG Pasteur and BCG Tokyo; D-xylulose kinase 823330..824676 Mycobacterium bovis BCG str. Tokyo 172 7560780 YP_002643811.1 CDS JTY_0750 NC_012207.1 824689 825417 D hypothetical protein 824689..825417 Mycobacterium bovis BCG str. Tokyo 172 7561701 YP_002643812.1 CDS JTY_0751 NC_012207.1 825506 826462 R hypothetical protein complement(825506..826462) Mycobacterium bovis BCG str. Tokyo 172 7561068 YP_002643813.1 CDS secY NC_012207.1 826623 827948 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 826623..827948 Mycobacterium bovis BCG str. Tokyo 172 7561069 YP_002643814.1 CDS adk NC_012207.1 827945 828490 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 827945..828490 Mycobacterium bovis BCG str. Tokyo 172 7560777 YP_002643815.1 CDS mapA NC_012207.1 828493 829293 D catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 828493..829293 Mycobacterium bovis BCG str. Tokyo 172 7563947 YP_002643816.1 CDS sigL NC_012207.1 829366 829899 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein regulates polyketide synthases and or membrane proteins; RNA polymerase sigma factor SigL 829366..829899 Mycobacterium bovis BCG str. Tokyo 172 7564418 YP_002643817.1 CDS JTY_0756 NC_012207.1 829963 830715 D hypothetical protein 829963..830715 Mycobacterium bovis BCG str. Tokyo 172 7561796 YP_002643818.1 CDS JTY_0757 NC_012207.1 831030 831527 D transcriptional regulatory protein 831030..831527 Mycobacterium bovis BCG str. Tokyo 172 7561070 YP_002643819.1 CDS JTY_0758 NC_012207.1 831885 832433 D hypothetical protein 831885..832433 Mycobacterium bovis BCG str. Tokyo 172 7561071 YP_002643820.1 CDS JTY_0759 NC_012207.1 832638 833486 D In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 2 bp insertion (*-CG) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (282 aa versus 268 aa); hypothetical protein 832638..833486 Mycobacterium bovis BCG str. Tokyo 172 7561072 YP_002643821.1 CDS JTY_0760 NC_012207.1 833601 834128 D hypothetical protein 833601..834128 Mycobacterium bovis BCG str. Tokyo 172 7561073 YP_002643822.1 CDS JTY_0761 NC_012207.1 834359 834673 D transposase 834359..834673 Mycobacterium bovis BCG str. Tokyo 172 7561074 YP_002643823.1 CDS PE_PGRS8 NC_012207.1 834815 835333 D PE-PGRS family protein 834815..835333 Mycobacterium bovis BCG str. Tokyo 172 7561075 YP_002643824.1 CDS JTY_0763 NC_012207.1 835711 836268 R hypothetical protein complement(835711..836268) Mycobacterium bovis BCG str. Tokyo 172 7562393 YP_002643825.1 CDS JTY_0764 NC_012207.1 836265 836771 R transcriptional regulatory protein complement(836265..836771) Mycobacterium bovis BCG str. Tokyo 172 7561076 YP_002643826.1 CDS JTY_0765 NC_012207.1 836979 837506 D hypothetical protein 836979..837506 Mycobacterium bovis BCG str. Tokyo 172 7561077 YP_002643827.1 CDS PE_PGRS9 NC_012207.1 837526 839919 D In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, two 48 bp deletions, and a 138 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (797 aa versus 783 aa). Differs from Mb0767 by 1aa S597N in BCG Pasteur and BCG Tokyo; PE-PGRS family protein 837526..839919 Mycobacterium bovis BCG str. Tokyo 172 7561078 YP_002643828.1 CDS PE_PGRS10 NC_012207.1 840318 842999 D In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, insertions of 168 bp and 105 bp, a 11 bp for 71 bp substitution, and a 9 bp deletion (CGGCAACGG-*), leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (909 aa and 893 aa versus 801 aa). In addition, in Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 48 bp deletion compared to Mycobacterium bovis and Mycobacterium tuberculosis strain H37Rv. occurs; PE-PGRS family protein 840318..842999 Mycobacterium bovis BCG str. Tokyo 172 7562394 YP_002643829.1 CDS JTY_0768 NC_012207.1 843090 843347 D hypothetical protein 843090..843347 Mycobacterium bovis BCG str. Tokyo 172 7561749 YP_002643830.1 CDS JTY_0769 NC_012207.1 843371 843799 D hypothetical protein 843371..843799 Mycobacterium bovis BCG str. Tokyo 172 7561079 YP_002643831.1 CDS JTY_0770 NC_012207.1 843880 844017 R hypothetical protein complement(843880..844017) Mycobacterium bovis BCG str. Tokyo 172 7561080 YP_002643832.1 CDS JTY_0771 NC_012207.1 844176 844421 D hypothetical protein 844176..844421 Mycobacterium bovis BCG str. Tokyo 172 7561081 YP_002643833.1 CDS mmsB NC_012207.1 844490 845374 R 3-hydroxyisobutyrate dehydrogenase complement(844490..845374) Mycobacterium bovis BCG str. Tokyo 172 7561082 YP_002643834.1 CDS fadE9 NC_012207.1 845385 846557 R Differs from Rv0752c by 2aa A69V and V186I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acyl-CoA dehydrogenase complement(845385..846557) Mycobacterium bovis BCG str. Tokyo 172 7563519 YP_002643835.1 CDS mmsA NC_012207.1 846564 848096 R Differs from Mb0775c by 1aa V442G in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methylmalonate-semialdehyde dehydrogenase complement(846564..848096) Mycobacterium bovis BCG str. Tokyo 172 7563392 YP_002643836.1 CDS PE_PGRS11 NC_012207.1 848302 850056 D PE-PGRS family protein 848302..850056 Mycobacterium bovis BCG str. Tokyo 172 7563518 YP_002643837.1 CDS PPE12 NC_012207.1 850246 852183 R Differs from Rv0755c by 1aa K545R in BCG Pasteur and BCG Tokyo; PPE family protein complement(850246..852183) Mycobacterium bovis BCG str. Tokyo 172 7561750 YP_002643838.1 CDS JTY_0777 NC_012207.1 852485 852670 R transposase complement(852485..852670) Mycobacterium bovis BCG str. Tokyo 172 7562147 YP_002643839.1 CDS JTY_0778 NC_012207.1 852884 853609 R hypothetical protein complement(852884..853609) Mycobacterium bovis BCG str. Tokyo 172 7561856 YP_002643840.1 CDS phoP NC_012207.1 855109 855852 D two component system response transcriptional positive regulator 855109..855852 Mycobacterium bovis BCG str. Tokyo 172 7561084 YP_002643841.1 CDS phoR NC_012207.1 855897 857354 D Differs from Rv0755c by 2aa I71G, L172P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; two component system response sensor kinase membrane associated 855897..857354 Mycobacterium bovis BCG str. Tokyo 172 7562411 YP_002643842.1 CDS JTY_0781 NC_012207.1 857326 857658 R hypothetical protein complement(857326..857658) Mycobacterium bovis BCG str. Tokyo 172 7562412 YP_002643843.1 CDS JTY_0782 NC_012207.1 857767 858186 R hypothetical protein complement(857767..858186) Mycobacterium bovis BCG str. Tokyo 172 7561085 YP_002643844.1 CDS adhB NC_012207.1 858199 859326 R zinc-containing alcohol dehydrogenase complement(858199..859326) Mycobacterium bovis BCG str. Tokyo 172 7561086 YP_002643845.1 CDS JTY_0784 NC_012207.1 859425 859970 R hypothetical protein complement(859425..859970) Mycobacterium bovis BCG str. Tokyo 172 7563942 YP_002643846.1 CDS JTY_0785 NC_012207.1 859973 860179 R ferredoxin complement(859973..860179) Mycobacterium bovis BCG str. Tokyo 172 7561087 YP_002643847.1 CDS cyp51 NC_012207.1 860182 861537 R cytochrome P450 51 complement(860182..861537) Mycobacterium bovis BCG str. Tokyo 172 7561088 YP_002643848.1 CDS JTY_0787 NC_012207.1 861537 862364 R short chain dehydrogenase complement(861537..862364) Mycobacterium bovis BCG str. Tokyo 172 7563171 YP_002643849.1 CDS cyp123 NC_012207.1 861946 863571 R cytochrome P450 123 complement(861946..863571) Mycobacterium bovis BCG str. Tokyo 172 7561089 YP_002643850.1 CDS JTY_0789 NC_012207.1 863568 864209 R hypothetical protein complement(863568..864209) Mycobacterium bovis BCG str. Tokyo 172 7563154 YP_002643851.1 CDS aldA NC_012207.1 864411 865880 D aldehyde dehydrogenase 864411..865880 Mycobacterium bovis BCG str. Tokyo 172 7561090 YP_002643852.1 CDS JTY_0791 NC_012207.1 865911 866657 D Differs from Rv0769 by 1aa V55A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; short chain dehydrogenase 865911..866657 Mycobacterium bovis BCG str. Tokyo 172 7563958 YP_002643853.1 CDS JTY_0792 NC_012207.1 866755 867642 D Differs from Mb0793 by 1aa V126G in BCG Pasteur and BCG Tokyo; dehydrogenase/reductase 866755..867642 Mycobacterium bovis BCG str. Tokyo 172 7561091 YP_002643854.1 CDS JTY_0793 NC_012207.1 867639 868073 D 4-carboxymuconolactone decarboxylase 867639..868073 Mycobacterium bovis BCG str. Tokyo 172 7561092 YP_002643855.1 CDS purD NC_012207.1 868085 869353 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 868085..869353 Mycobacterium bovis BCG str. Tokyo 172 7561093 YP_002643856.1 CDS ggtA NC_012207.1 869350 870888 R gamma-glutamyltranspeptidase; cephalosporin acylase complement(869350..870888) Mycobacterium bovis BCG str. Tokyo 172 7560857 YP_002643857.1 CDS JTY_0796 NC_012207.1 870939 871850 R Differs from Rv0774c by 1aa A219S and from Mb0797c by 1aa D142A in BCG Pasteur and BCG Tokyo; hypothetical protein complement(870939..871850) Mycobacterium bovis BCG str. Tokyo 172 7561913 YP_002643858.1 CDS JTY_0797 NC_012207.1 871906 872529 D hypothetical protein 871906..872529 Mycobacterium bovis BCG str. Tokyo 172 7561094 YP_002643859.1 CDS JTY_0798 NC_012207.1 872483 873262 R hypothetical protein complement(872483..873262) Mycobacterium bovis BCG str. Tokyo 172 7561095 YP_002643860.1 CDS purB NC_012207.1 873507 874925 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 873507..874925 Mycobacterium bovis BCG str. Tokyo 172 7561096 YP_002643861.1 CDS cyp126 NC_012207.1 874930 876174 D cytochrome P450 126 874930..876174 Mycobacterium bovis BCG str. Tokyo 172 7560855 YP_002643862.1 CDS JTY_0801 NC_012207.1 876171 876791 R transmembrane protein complement(876171..876791) Mycobacterium bovis BCG str. Tokyo 172 7563157 YP_002643863.1 CDS purC NC_012207.1 876842 877735 D catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 876842..877735 Mycobacterium bovis BCG str. Tokyo 172 7561097 YP_002643864.1 CDS ptrB NC_012207.1 877732 879891 D In Mycobacterium tuberculosis strain H37Rv, ptrB is split into 2 genes, ptrBa and ptrBb, due to a frameshift. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 2 bp insertion (*-gc) leads to a single product; oligopeptidase B; protease II 877732..879891 Mycobacterium bovis BCG str. Tokyo 172 7560856 YP_002643865.1 CDS emrB NC_012207.1 880319 881941 R multidrug resistance integral membrane efflux protein complement(880319..881941) Mycobacterium bovis BCG str. Tokyo 172 7560853 YP_002643866.1 CDS JTY_0805 NC_012207.1 882139 882825 D hypothetical protein 882139..882825 Mycobacterium bovis BCG str. Tokyo 172 7562862 YP_002643867.1 CDS JTY_0806 NC_012207.1 882841 883416 D In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (T-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808; hypothetical protein 882841..883416 Mycobacterium bovis BCG str. Tokyo 172 7561098 YP_002643868.1 CDS JTY_0807 NC_012207.1 883434 884540 D In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo, a frameshift due to a single base deletion (T-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808; hypothetical protein 883434..884540 Mycobacterium bovis BCG str. Tokyo 172 7561099 YP_002643869.1 CDS JTY_0808 NC_012207.1 884575 884964 R hypothetical protein complement(884575..884964) Mycobacterium bovis BCG str. Tokyo 172 7561100 YP_002643870.1 CDS JTY_0809 NC_012207.1 884959 885918 D Differs from Rv0787 by 1aa H269Y in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 884959..885918 Mycobacterium bovis BCG str. Tokyo 172 7561101 YP_002643871.1 CDS JTY_0810 NC_012207.1 886024 886263 D With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway; phosphoribosylformylglycinamidine synthase subunit PurS 886024..886263 Mycobacterium bovis BCG str. Tokyo 172 7561102 YP_002643872.1 CDS purQ NC_012207.1 886260 886934 D catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I 886260..886934 Mycobacterium bovis BCG str. Tokyo 172 7561103 YP_002643873.1 CDS JTY_0812 NC_012207.1 886951 887550 R hypothetical protein complement(886951..887550) Mycobacterium bovis BCG str. Tokyo 172 7560865 YP_002643874.1 CDS JTY_0813 NC_012207.1 887572 888300 R hypothetical protein complement(887572..888300) Mycobacterium bovis BCG str. Tokyo 172 7561104 YP_002643875.1 CDS JTY_0814 NC_012207.1 888297 889340 R hypothetical protein complement(888297..889340) Mycobacterium bovis BCG str. Tokyo 172 7561105 YP_002643876.1 CDS JTY_0815 NC_012207.1 889337 890146 R probably GntR-family; transcriptional regulatory protein complement(889337..890146) Mycobacterium bovis BCG str. Tokyo 172 7561106 YP_002643877.1 CDS JTY_0816 NC_012207.1 890219 890524 D hypothetical protein 890219..890524 Mycobacterium bovis BCG str. Tokyo 172 7561107 YP_002643878.1 CDS JTY_0817 NC_012207.1 890637 891248 R In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (a-*) splits Rv0794c into 2 parts; oxidoreductase complement(890637..891248) Mycobacterium bovis BCG str. Tokyo 172 7561108 YP_002643879.1 CDS JTY_0818 NC_012207.1 891236 892135 R In Mycobacterium tuberculosis strain H37Rv, Rv0794c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (a-*) splits Rv0794c into 2 parts; oxidoreductase complement(891236..892135) Mycobacterium bovis BCG str. Tokyo 172 7561109 YP_002643880.1 CDS cfp29 NC_012207.1 893611 894408 R hypothetical protein complement(893611..894408) Mycobacterium bovis BCG str. Tokyo 172 7561111 YP_002643881.1 CDS JTY_0821 NC_012207.1 894405 895412 R hypothetical protein complement(894405..895412) Mycobacterium bovis BCG str. Tokyo 172 7562100 YP_002643882.1 CDS pepC NC_012207.1 895457 896758 D catalyzes the removal of amino acids from the N termini of peptides; aminopeptidase 2 895457..896758 Mycobacterium bovis BCG str. Tokyo 172 7561112 YP_002643883.1 CDS JTY_0823 NC_012207.1 896770 897117 D hypothetical protein 896770..897117 Mycobacterium bovis BCG str. Tokyo 172 7561743 YP_002643884.1 CDS JTY_0824 NC_012207.1 897111 897767 R hypothetical protein complement(897111..897767) Mycobacterium bovis BCG str. Tokyo 172 7561113 YP_002643885.1 CDS purL NC_012207.1 897959 900223 D catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II 897959..900223 Mycobacterium bovis BCG str. Tokyo 172 7561114 YP_002643886.1 CDS JTY_0826 NC_012207.1 900220 900849 D hypothetical protein 900220..900849 Mycobacterium bovis BCG str. Tokyo 172 7560862 YP_002643887.1 CDS JTY_0827 NC_012207.1 900970 901926 D hypothetical protein 900970..901926 Mycobacterium bovis BCG str. Tokyo 172 7561115 YP_002643888.1 CDS cpsY NC_012207.1 901871 903469 R UDP-glucose-4-epimerase complement(901871..903469) Mycobacterium bovis BCG str. Tokyo 172 7561116 YP_002643889.1 CDS JTY_0829 NC_012207.1 903774 904163 D hypothetical protein 903774..904163 Mycobacterium bovis BCG str. Tokyo 172 7563122 YP_002643890.1 CDS purF NC_012207.1 904250 905833 D Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 904250..905833 Mycobacterium bovis BCG str. Tokyo 172 7561117 YP_002643891.1 CDS purM NC_012207.1 905864 906958 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 905864..906958 Mycobacterium bovis BCG str. Tokyo 172 7560859 YP_002643892.1 CDS JTY_0832 NC_012207.1 907044 907226 R hypothetical protein complement(907044..907226) Mycobacterium bovis BCG str. Tokyo 172 7560863 YP_002643893.1 CDS JTY_0833 NC_012207.1 907373 908479 R hypothetical protein complement(907373..908479) Mycobacterium bovis BCG str. Tokyo 172 7561118 YP_002643894.1 CDS JTY_0834 NC_012207.1 908562 909431 D catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 908562..909431 Mycobacterium bovis BCG str. Tokyo 172 7561119 YP_002643895.1 CDS JTY_0835 NC_012207.1 909477 910157 R hypothetical protein complement(909477..910157) Mycobacterium bovis BCG str. Tokyo 172 7561120 YP_002643896.1 CDS sseC2 NC_012207.1 910320 910622 R hypothetical protein complement(910320..910622) Mycobacterium bovis BCG str. Tokyo 172 7561121 YP_002643897.1 CDS cysA2 NC_012207.1 910624 911457 R thiosulfate sulfurtransferase complement(910624..911457) Mycobacterium bovis BCG str. Tokyo 172 7561810 YP_002643898.1 CDS thiX NC_012207.1 911750 912172 R thioredoxin complement(911750..912172) Mycobacterium bovis BCG str. Tokyo 172 7563173 YP_002643899.1 CDS JTY_0839 NC_012207.1 912169 912981 R hypothetical protein complement(912169..912981) Mycobacterium bovis BCG str. Tokyo 172 7561849 YP_002643900.1 CDS JTY_0840 NC_012207.1 913111 913878 D Differs from Rv0818 by 1aa P97L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional regulatory protein 913111..913878 Mycobacterium bovis BCG str. Tokyo 172 7561954 YP_002643901.1 CDS JTY_0841 NC_012207.1 913875 914822 D hypothetical protein 913875..914822 Mycobacterium bovis BCG str. Tokyo 172 7561955 YP_002643902.1 CDS phoTa NC_012207.1 914865 915377 D In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis phoT exists as a single gene. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a frameshift due to a single base deletion (G-*), splits phoT into two parts phoTa and phoTb. Differs from Rv0820 by 1aa L35F in BCG Pasteur and BCG Tokyo; phosphate-transport ATP-binding protein ABC transporter 914865..915377 Mycobacterium bovis BCG str. Tokyo 172 7561956 YP_002643903.1 CDS phoY2 NC_012207.1 915696 916337 R phosphate-transport system transcriptional regulatory protein complement(915696..916337) Mycobacterium bovis BCG str. Tokyo 172 7562414 YP_002643904.1 CDS JTY_0845 NC_012207.1 916395 918449 R Differs from Rv0822c by 1aa P89H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(916395..918449) Mycobacterium bovis BCG str. Tokyo 172 7562418 YP_002643905.1 CDS JTY_0846 NC_012207.1 918615 919784 R Differs from Rv0823c by 2aa C130G and L330F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional regulatory protein complement(918615..919784) Mycobacterium bovis BCG str. Tokyo 172 7561957 YP_002643906.1 CDS desA1 NC_012207.1 919872 920888 R acyl-ACP desaturase complement(919872..920888) Mycobacterium bovis BCG str. Tokyo 172 7561958 YP_002643907.1 CDS JTY_0848 NC_012207.1 921050 921691 R hypothetical protein complement(921050..921691) Mycobacterium bovis BCG str. Tokyo 172 7561483 YP_002643908.1 CDS JTY_0849 NC_012207.1 921772 922827 D Differs from Rv0826 by 1aa Q294R and Mb0849 by 1aaE97G in BCG Pasteur and BCG Tokyo; hypothetical protein 921772..922827 Mycobacterium bovis BCG str. Tokyo 172 7561959 YP_002643909.1 CDS JTY_0850 NC_012207.1 922879 923271 R transcriptional regulatory protein complement(922879..923271) Mycobacterium bovis BCG str. Tokyo 172 7561960 YP_002643910.1 CDS JTY_0851 NC_012207.1 923329 923751 R deaminase complement(923329..923751) Mycobacterium bovis BCG str. Tokyo 172 7561961 YP_002643911.1 CDS JTY_0852 NC_012207.1 923713 924003 D Differs from Rv0829 by 1aa G80A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transposase 923713..924003 Mycobacterium bovis BCG str. Tokyo 172 7561962 YP_002643912.1 CDS JTY_0853 NC_012207.1 924108 925013 D hypothetical protein 924108..925013 Mycobacterium bovis BCG str. Tokyo 172 7561963 YP_002643913.1 CDS JTY_0854 NC_012207.1 925032 925847 R hypothetical protein complement(925032..925847) Mycobacterium bovis BCG str. Tokyo 172 7561964 YP_002643914.1 CDS PE_PGRS13 NC_012207.1 927089 929821 D In Mycobacterium bovis BCG Pasteur and BCG Tokyo, PE-PGRS13 exist as a single gene. In Mycobacterium tuberculosis and Mycobacterium bovis, it is splitted in 2 genes PE-PGRS12 and PE-PGRS13; PE-PGRS family protein 927089..929821 Mycobacterium bovis BCG str. Tokyo 172 7562407 YP_002643915.1 CDS PE_PGRS14 NC_012207.1 930048 932696 R In Mycobacterium bovis, deletions of 143 bp and 9 bp (cgccgttgc-*), leads to a shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (831 aa versus 882 aa); PE-PGRS family protein complement(930048..932696) Mycobacterium bovis BCG str. Tokyo 172 7561751 YP_002643916.1 CDS lpqQ NC_012207.1 933164 933808 D Differs from Rv0835 by 1aa G162D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 933164..933808 Mycobacterium bovis BCG str. Tokyo 172 7561752 YP_002643917.1 CDS JTY_0858 NC_012207.1 934421 935143 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (a-g) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (240 aa versus 217 aa); hypothetical protein complement(934421..935143) Mycobacterium bovis BCG str. Tokyo 172 7560509 YP_002643918.1 CDS JTY_0859 NC_012207.1 935214 936242 R hypothetical protein complement(935214..936242) Mycobacterium bovis BCG str. Tokyo 172 7561966 YP_002643919.1 CDS lpqR NC_012207.1 936931 937713 D In Mycobacterium bovis, a 6bp insertion (*-CGGCCC) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (258 aa versus 256 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 12bp insertion (compared to its homolog in Mycobacterium tuberculosis strain H37Rv) and a 6bp insertion (compared to its homolog in Mycobacterium bovis) leads to an even longer product (260 aa); lipoprotein 936931..937713 Mycobacterium bovis BCG str. Tokyo 172 7561967 YP_002643920.1 CDS JTY_0861 NC_012207.1 937800 938612 D hypothetical protein 937800..938612 Mycobacterium bovis BCG str. Tokyo 172 7560510 YP_002643921.1 CDS pip NC_012207.1 938680 939540 R proline iminopeptidase complement(938680..939540) Mycobacterium bovis BCG str. Tokyo 172 7561968 YP_002643922.1 CDS JTY_0863 NC_012207.1 939816 940058 D Differs from Rv0841 by 1aa F29V in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; transmembrane protein 939816..940058 Mycobacterium bovis BCG str. Tokyo 172 7562424 YP_002643923.1 CDS JTY_0864 NC_012207.1 940335 941627 D integral membrane protein 940335..941627 Mycobacterium bovis BCG str. Tokyo 172 7561969 YP_002643924.1 CDS JTY_0865 NC_012207.1 941611 942615 D Differs from Rv0843 by 1aa G191D and from Mb0866 by 1aa A309D in BCG Pasteur and BCG Tokyo; dehydrogenase 941611..942615 Mycobacterium bovis BCG str. Tokyo 172 7561970 YP_002643925.1 CDS narL NC_012207.1 942679 943329 R Differs from Mb0867c by 1aa A73P in BCG Pasteur and BCG Tokyo; nitrate/nitrite response transcriptional regulatory protein complement(942679..943329) Mycobacterium bovis BCG str. Tokyo 172 7561971 YP_002643926.1 CDS JTY_0867 NC_012207.1 943413 944690 D Differs from Rv0845 by 1aa E219A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; two component sensor kinase 943413..944690 Mycobacterium bovis BCG str. Tokyo 172 7562452 YP_002643927.1 CDS JTY_0868 NC_012207.1 944903 946417 R Differs from Mb0869c by 1aa Y411H in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidase complement(944903..946417) Mycobacterium bovis BCG str. Tokyo 172 7561972 YP_002643928.1 CDS lpqS NC_012207.1 946566 946958 D Differs from Rv0847 by 1aa V128A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 946566..946958 Mycobacterium bovis BCG str. Tokyo 172 7561973 YP_002643929.1 CDS cysK2 NC_012207.1 947161 948279 D Differs from Rv0848 by 1aa S93G, and from Mb0871 by 1aa V137G in BCG Pasteur and BCG Tokyo; cysteine synthase A 947161..948279 Mycobacterium bovis BCG str. Tokyo 172 7560511 YP_002643930.1 CDS JTY_0871 NC_012207.1 948279 949538 D integral membrane transport protein 948279..949538 Mycobacterium bovis BCG str. Tokyo 172 7563179 YP_002643931.1 CDS JTY_0872 NC_012207.1 949535 949867 D transposase 949535..949867 Mycobacterium bovis BCG str. Tokyo 172 7561974 YP_002643932.1 CDS JTY_0873 NC_012207.1 949864 950691 R Differs from Rv0851c by 1aa G59S and from Mb0874c by 1aa V84F in BCG Pasteur and BCG Tokyo; short chain dehydrogenase complement(949864..950691) Mycobacterium bovis BCG str. Tokyo 172 7561975 YP_002643933.1 CDS fadD16 NC_012207.1 950782 951618 D fatty-acid-CoA ligase 950782..951618 Mycobacterium bovis BCG str. Tokyo 172 7561976 YP_002643934.1 CDS pdc NC_012207.1 951659 953341 R pyruvate or indole-3-pyruvate decarboxylase complement(951659..953341) Mycobacterium bovis BCG str. Tokyo 172 7562922 YP_002643935.1 CDS JTY_0876 NC_012207.1 953406 953849 D hypothetical protein 953406..953849 Mycobacterium bovis BCG str. Tokyo 172 7562526 YP_002643936.1 CDS far NC_012207.1 953855 954934 D fatty-acid-CoA racemase 953855..954934 Mycobacterium bovis BCG str. Tokyo 172 7561977 YP_002643937.1 CDS JTY_0878 NC_012207.1 955047 955451 D hypothetical protein 955047..955451 Mycobacterium bovis BCG str. Tokyo 172 7563394 YP_002643938.1 CDS JTY_0879 NC_012207.1 955479 955952 D hypothetical protein 955479..955952 Mycobacterium bovis BCG str. Tokyo 172 7561978 YP_002643939.1 CDS JTY_0880 NC_012207.1 955949 957142 R aminotransferase complement(955949..957142) Mycobacterium bovis BCG str. Tokyo 172 7561979 YP_002643940.1 CDS fadA NC_012207.1 957299 958510 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 957299..958510 Mycobacterium bovis BCG str. Tokyo 172 7561980 YP_002643941.1 CDS fadB NC_012207.1 958515 960677 D Differs from Rv0860 by 1aa T701A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; fatty oxidation protein 958515..960677 Mycobacterium bovis BCG str. Tokyo 172 7562904 YP_002643942.1 CDS JTY_0883 NC_012207.1 960745 962373 R Differs from Rv0861c by 1aa A258V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; DNA helicase complement(960745..962373) Mycobacterium bovis BCG str. Tokyo 172 7562910 YP_002643943.1 CDS JTY_0884 NC_012207.1 962511 964781 R Differs from Rv0862c by 2aa F224L and S749L, and from Mb0885c by 1aa F224L in BCG Pasteur and BCG Tokyo; hypothetical protein complement(962511..964781) Mycobacterium bovis BCG str. Tokyo 172 7561981 YP_002643944.1 CDS JTY_0885 NC_012207.1 964768 965049 D hypothetical protein 964768..965049 Mycobacterium bovis BCG str. Tokyo 172 7561982 YP_002643945.1 CDS moaC NC_012207.1 965133 965561 D MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 965133..965561 Mycobacterium bovis BCG str. Tokyo 172 7561983 YP_002643946.1 CDS mog NC_012207.1 965558 966040 D molybdopterin biosynthesis protein 965558..966040 Mycobacterium bovis BCG str. Tokyo 172 7563530 YP_002643947.1 CDS moaE2 NC_012207.1 966037 966462 D molybdenum cofactor biosynthesis protein E2 966037..966462 Mycobacterium bovis BCG str. Tokyo 172 7563546 YP_002643948.1 CDS rpfA NC_012207.1 966480 967703 R In Mycobacterium bovis, a 240 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (327 aa versus 407 aa). Differs from Rv0867c by 1aa E235D in BCG Pasteur and BCG Tokyo.; resuscitation-promoting factor complement(966480..967703) Mycobacterium bovis BCG str. Tokyo 172 7563533 YP_002643949.1 CDS moaD2 NC_012207.1 968151 968429 R molybdenum cofactor biosynthesis protein D 2 complement(968151..968429) Mycobacterium bovis BCG str. Tokyo 172 7561596 YP_002643950.1 CDS moaA NC_012207.1 968433 969515 R together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A complement(968433..969515) Mycobacterium bovis BCG str. Tokyo 172 7563532 YP_002643951.1 CDS JTY_0892 NC_012207.1 969512 969901 R Differs from Mb0894c by 1aa G29S; hypothetical protein complement(969512..969901) Mycobacterium bovis BCG str. Tokyo 172 7563522 YP_002643952.1 CDS cspB NC_012207.1 970066 970473 D cold shock-like protein B 970066..970473 Mycobacterium bovis BCG str. Tokyo 172 7561984 YP_002643953.1 CDS PE_PGRS15 NC_012207.1 970592 972421 R In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 9 bp in-frame insertion (compared to Mycobacterium tuberculosis strain H37Rv), leads to a lightly longer product (609 aa versus 606 aa). In Mycobacterium bovis, an additional 3 bp in-frame deletion (compared to Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur and BCG Tokyo) leads to a product of 608 aa; PE-PGRS family protein complement(970592..972421) Mycobacterium bovis BCG str. Tokyo 172 7563125 YP_002643954.1 CDS fadE10 NC_012207.1 972682 974634 D acyl-CoA dehydrogenase 972682..974634 Mycobacterium bovis BCG str. Tokyo 172 7561753 YP_002643955.1 CDS JTY_0896 NC_012207.1 974723 975883 R hypothetical protein complement(974723..975883) Mycobacterium bovis BCG str. Tokyo 172 7563359 YP_002643956.1 CDS JTY_0897 NC_012207.1 975983 976471 R hypothetical protein complement(975983..976471) Mycobacterium bovis BCG str. Tokyo 172 7561985 YP_002643957.1 CDS JTY_0898 NC_012207.1 976468 978114 R Differs from Mb0900c by 1aa D26G in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein complement(976468..978114) Mycobacterium bovis BCG str. Tokyo 172 7561986 YP_002643958.1 CDS JTY_0899 NC_012207.1 978252 979040 D hypothetical protein 978252..979040 Mycobacterium bovis BCG str. Tokyo 172 7561987 YP_002643959.1 CDS PPE13 NC_012207.1 979049 980377 R In Mycobacterium bovis, Mycobaterium bovis BCG Pasteur, and BCG Tokyo, a single base deletion (A-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (438 aa versus 443 aa). Differs from Rv0878c and Mb0902c by 1aa K436Q in BCG Pasteur and BCG Tokyo; PPE family protein complement(979049..980377) Mycobacterium bovis BCG str. Tokyo 172 7561988 YP_002643960.1 CDS JTY_0901 NC_012207.1 980655 980930 R transmembrane protein complement(980655..980930) Mycobacterium bovis BCG str. Tokyo 172 7562148 YP_002643961.1 CDS JTY_0902 NC_012207.1 981108 981539 D possibly MarR-family; transcriptional regulatory protein 981108..981539 Mycobacterium bovis BCG str. Tokyo 172 7561989 YP_002643962.1 CDS JTY_0903 NC_012207.1 981536 982402 D rRNA methyltransferase 981536..982402 Mycobacterium bovis BCG str. Tokyo 172 7561990 YP_002643963.1 CDS JTY_0904 NC_012207.1 982399 982683 D transmembrane protein 982399..982683 Mycobacterium bovis BCG str. Tokyo 172 7561991 YP_002643964.1 CDS JTY_0905 NC_012207.1 982680 983441 R hypothetical protein complement(982680..983441) Mycobacterium bovis BCG str. Tokyo 172 7561992 YP_002643965.1 CDS serC NC_012207.1 983598 984728 R catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase complement(983598..984728) Mycobacterium bovis BCG str. Tokyo 172 7561993 YP_002643966.1 CDS JTY_0907 NC_012207.1 984936 985958 D hypothetical protein 984936..985958 Mycobacterium bovis BCG str. Tokyo 172 7560783 YP_002643967.1 CDS fprB NC_012207.1 985977 987704 D NADPH:adrenodoxin oxidoreductase 985977..987704 Mycobacterium bovis BCG str. Tokyo 172 7561994 YP_002643968.1 CDS JTY_0909 NC_012207.1 987687 988145 R hypothetical protein complement(987687..988145) Mycobacterium bovis BCG str. Tokyo 172 7563428 YP_002643969.1 CDS JTY_0910 NC_012207.1 989407 990879 D hypothetical protein 989407..990879 Mycobacterium bovis BCG str. Tokyo 172 7561995 YP_002643970.1 CDS citA NC_012207.1 990914 992035 R forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; citrate synthase 2 complement(990914..992035) Mycobacterium bovis BCG str. Tokyo 172 7561996 YP_002643971.1 CDS JTY_0912 NC_012207.1 992122 994770 R Differs from Rv0890c by 1aa A866P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably LuxR-family; transcriptional regulatory protein complement(992122..994770) Mycobacterium bovis BCG str. Tokyo 172 7562105 YP_002643972.1 CDS JTY_0913 NC_012207.1 994772 995629 R Differs from Rv0891c by 1aa G37V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional regulatory protein complement(994772..995629) Mycobacterium bovis BCG str. Tokyo 172 7561997 YP_002643973.1 CDS JTY_0914 NC_012207.1 996027 997514 D monooxygenase 996027..997514 Mycobacterium bovis BCG str. Tokyo 172 7561998 YP_002643974.1 CDS JTY_0915 NC_012207.1 997492 998469 R hypothetical protein complement(997492..998469) Mycobacterium bovis BCG str. Tokyo 172 7561999 YP_002643975.1 CDS JTY_0916 NC_012207.1 998698 999879 D possibly LuxR-family; transcriptional regulatory protein 998698..999879 Mycobacterium bovis BCG str. Tokyo 172 7562000 YP_002643976.1 CDS JTY_0917 NC_012207.1 999956 1001473 D hypothetical protein 999956..1001473 Mycobacterium bovis BCG str. Tokyo 172 7562001 YP_002643977.1 CDS gltA NC_012207.1 1001663 1002958 D type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 1001663..1002958 Mycobacterium bovis BCG str. Tokyo 172 7562002 YP_002643978.1 CDS JTY_0919 NC_012207.1 1002999 1004606 R oxidoreductase complement(1002999..1004606) Mycobacterium bovis BCG str. Tokyo 172 7561945 YP_002643979.1 CDS JTY_0920 NC_012207.1 1004632 1004895 R hypothetical protein complement(1004632..1004895) Mycobacterium bovis BCG str. Tokyo 172 7562003 YP_002643980.1 CDS ompA NC_012207.1 1005003 1005983 D outer membrane protein A 1005003..1005983 Mycobacterium bovis BCG str. Tokyo 172 7562004 YP_002643981.1 CDS JTY_0922 NC_012207.1 1005996 1006148 D hypothetical protein 1005996..1006148 Mycobacterium bovis BCG str. Tokyo 172 7562493 YP_002643982.1 CDS JTY_0923 NC_012207.1 1006148 1006675 D exported or membrane protein 1006148..1006675 Mycobacterium bovis BCG str. Tokyo 172 7562005 YP_002643983.1 CDS prrB NC_012207.1 1006692 1008032 R two component sensor histidine kinase complement(1006692..1008032) Mycobacterium bovis BCG str. Tokyo 172 7562006 YP_002643984.1 CDS prrA NC_012207.1 1008043 1008753 R two component response transcriptional regulatory protein complement(1008043..1008753) Mycobacterium bovis BCG str. Tokyo 172 7560836 YP_002643985.1 CDS accD3 NC_012207.1 1008884 1010371 R acetyl-coenzyme A carboxylase carboxyl transferase subunit beta complement(1008884..1010371) Mycobacterium bovis BCG str. Tokyo 172 7560835 YP_002643986.1 CDS echA6 NC_012207.1 1010398 1011129 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1010398..1011129 Mycobacterium bovis BCG str. Tokyo 172 7563923 YP_002643987.1 CDS JTY_0928 NC_012207.1 1011135 1012253 D hypothetical protein 1011135..1012253 Mycobacterium bovis BCG str. Tokyo 172 7561537 YP_002643988.1 CDS JTY_0929 NC_012207.1 1012346 1013926 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-G) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Rv0907 by 1aa, L322P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1012346..1013926 Mycobacterium bovis BCG str. Tokyo 172 7562007 YP_002643989.1 CDS ctpE NC_012207.1 1013923 1016316 D metal cation transporter ATPase P-type 1013923..1016316 Mycobacterium bovis BCG str. Tokyo 172 7562008 YP_002643990.1 CDS JTY_0931 NC_012207.1 1016873 1017052 D Differs from Rv0909 by 1aa, Q45H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1016873..1017052 Mycobacterium bovis BCG str. Tokyo 172 7563135 YP_002643991.1 CDS JTY_0932 NC_012207.1 1017058 1017492 D hypothetical protein 1017058..1017492 Mycobacterium bovis BCG str. Tokyo 172 7562009 YP_002643992.1 CDS JTY_0933 NC_012207.1 1017590 1018363 D hypothetical protein 1017590..1018363 Mycobacterium bovis BCG str. Tokyo 172 7562010 YP_002643993.1 CDS JTY_0934 NC_012207.1 1018428 1018877 D transmembrane protein 1018428..1018877 Mycobacterium bovis BCG str. Tokyo 172 7562011 YP_002643994.1 CDS JTY_0935 NC_012207.1 1019409 1020917 R Differs from Mb0937c by 1aa P233L in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; dioxygenase complement(1019409..1020917) Mycobacterium bovis BCG str. Tokyo 172 7562012 YP_002643995.1 CDS JTY_0936 NC_012207.1 1020919 1022157 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(1020919..1022157) Mycobacterium bovis BCG str. Tokyo 172 7562013 YP_002643996.1 CDS PPE14 NC_012207.1 1022250 1023521 R PPE family protein complement(1022250..1023521) Mycobacterium bovis BCG str. Tokyo 172 7562014 YP_002643997.1 CDS PE7 NC_012207.1 1023536 1023835 R PE family protein complement(1023536..1023835) Mycobacterium bovis BCG str. Tokyo 172 7562149 YP_002643998.1 CDS betP NC_012207.1 1024279 1026060 D glycine betaine transport integral membrane protein 1024279..1026060 Mycobacterium bovis BCG str. Tokyo 172 7561738 YP_002643999.1 CDS JTY_0940 NC_012207.1 1026403 1026879 D Differs from Rv0918 by 1aa, G46S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1026403..1026879 Mycobacterium bovis BCG str. Tokyo 172 7562062 YP_002644000.1 CDS JTY_0941 NC_012207.1 1026876 1027376 D hypothetical protein 1026876..1027376 Mycobacterium bovis BCG str. Tokyo 172 7562015 YP_002644001.1 CDS JTY_0942 NC_012207.1 1027689 1029008 R Differs from Rv0920c by 1aa, E249D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transposase complement(1027689..1029008) Mycobacterium bovis BCG str. Tokyo 172 7563992 YP_002644002.1 CDS JTY_0943 NC_012207.1 1029296 1029877 D resolvase 1029296..1029877 Mycobacterium bovis BCG str. Tokyo 172 7562017 YP_002644003.1 CDS JTY_0944 NC_012207.1 1029877 1031529 D transposase 1029877..1031529 Mycobacterium bovis BCG str. Tokyo 172 7562018 YP_002644004.1 CDS JTY_0945 NC_012207.1 1031705 1032769 R hypothetical protein complement(1031705..1032769) Mycobacterium bovis BCG str. Tokyo 172 7562019 YP_002644005.1 CDS mntH NC_012207.1 1032770 1034056 R In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, Rv0924c and Rv0925c exist as 2 genes. In Mycobacterium bovis, a single base deletion (T-*) leads to a single product, Mb0948c. Differs from Rv0924c by 1aa, A216P in BCG Pasteur and BCG Tokyo; manganese transport protein MntH complement(1032770..1034056) Mycobacterium bovis BCG str. Tokyo 172 7562020 YP_002644006.1 CDS JTY_0947 NC_012207.1 1034088 1034825 R In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, Rv0924c and Rv0925c exist as 2 genes. In Mycobacterium bovis, a single base deletion (t-*) leads to a single product, Mb0948c; Nramp; Mramp; divalent cation-transport integral membrane protein complement(1034088..1034825) Mycobacterium bovis BCG str. Tokyo 172 7563521 YP_002644007.1 CDS JTY_0948 NC_012207.1 1034902 1035978 R hypothetical protein complement(1034902..1035978) Mycobacterium bovis BCG str. Tokyo 172 7562021 YP_002644008.1 CDS JTY_0949 NC_012207.1 1036032 1036823 R short chain dehydrogenase complement(1036032..1036823) Mycobacterium bovis BCG str. Tokyo 172 7562022 YP_002644009.1 CDS pstS3 NC_012207.1 1037095 1038207 D periplasmic phosphate-binding lipoprotein 1037095..1038207 Mycobacterium bovis BCG str. Tokyo 172 7562023 YP_002644010.1 CDS pstC2 NC_012207.1 1038220 1039194 D phosphate ABC transporter permease 1038220..1039194 Mycobacterium bovis BCG str. Tokyo 172 7560848 YP_002644011.1 CDS pstA1 NC_012207.1 1039191 1040105 D Differs from Rv0930 by 1aa, T5M in Mycobacterium CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; phosphate-transport integral membrane ABC transporter 1039191..1040105 Mycobacterium bovis BCG str. Tokyo 172 7560845 YP_002644012.1 CDS pknDb NC_012207.1 1040112 1041221 R In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-T) splits pknD into 2 parts,pknDa and pknDb; hypothetical protein complement(1040112..1041221) Mycobacterium bovis BCG str. Tokyo 172 7560840 YP_002644013.1 CDS pknDa NC_012207.1 1041232 1042107 R In Mycobacterium tuberculosis strain H37Rv, pknD exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-T) splits pknD into 2 parts,pknDa and pknDb; transmembrane serine/threonine-protein kinase complement(1041232..1042107) Mycobacterium bovis BCG str. Tokyo 172 7562431 YP_002644014.1 CDS pstS2 NC_012207.1 1042129 1043241 R Differs from Rv0932c by 1aa, A115S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; periplasmic phosphate-binding lipoprotein complement(1042129..1043241) Mycobacterium bovis BCG str. Tokyo 172 7562430 YP_002644015.1 CDS pstBa NC_012207.1 1043457 1043672 D In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-T, position 1041448-1041449) splits pstB into 2 parts, pstBa and pstBb; phosphate-transport protein ABC transporter 1043457..1043672 Mycobacterium bovis BCG str. Tokyo 172 7560847 YP_002644016.1 CDS pstBb NC_012207.1 1043647 1044288 D In Mycobacterium tuberculosis strain H37Rv, pstB exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-T, position 1041448-1041449) splits pstB into 2 parts, pstBa and pstBb; phosphate-transport protein ABC transporter 1043647..1044288 Mycobacterium bovis BCG str. Tokyo 172 7560842 YP_002644017.1 CDS pstS1 NC_012207.1 1044309 1045433 D Differs from Rv0934 by 1aa, A352V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; periplasmic phosphate-binding lipoprotein 1044309..1045433 Mycobacterium bovis BCG str. Tokyo 172 7560843 YP_002644018.1 CDS pstC1 NC_012207.1 1045493 1046509 D phosphate ABC transporter permease 1045493..1046509 Mycobacterium bovis BCG str. Tokyo 172 7560846 YP_002644019.1 CDS pstA2 NC_012207.1 1046511 1047416 D phosphate ABC transporter permease 1046511..1047416 Mycobacterium bovis BCG str. Tokyo 172 7560844 YP_002644020.1 CDS JTY_0961 NC_012207.1 1047393 1048214 R hypothetical protein complement(1047393..1048214) Mycobacterium bovis BCG str. Tokyo 172 7560841 YP_002644021.1 CDS JTY_0962 NC_012207.1 1048330 1050609 D catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA and has been shown to have polymerase activity; ATP-dependent DNA ligase 1048330..1050609 Mycobacterium bovis BCG str. Tokyo 172 7562024 YP_002644022.1 CDS JTY_0963 NC_012207.1 1050606 1052540 D cyclase/dehydrase; 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase 1050606..1052540 Mycobacterium bovis BCG str. Tokyo 172 7562025 YP_002644023.1 CDS JTY_0964 NC_012207.1 1052787 1053653 R oxidoreductase complement(1052787..1053653) Mycobacterium bovis BCG str. Tokyo 172 7562026 YP_002644024.1 CDS JTY_0965 NC_012207.1 1053738 1054511 R hypothetical protein complement(1053738..1054511) Mycobacterium bovis BCG str. Tokyo 172 7562027 YP_002644025.1 CDS JTY_0966 NC_012207.1 1054554 1054832 D hypothetical protein 1054554..1054832 Mycobacterium bovis BCG str. Tokyo 172 7562028 YP_002644026.1 CDS JTY_0967 NC_012207.1 1054890 1055930 R monooxygenase complement(1054890..1055930) Mycobacterium bovis BCG str. Tokyo 172 7562029 YP_002644027.1 CDS JTY_0968 NC_012207.1 1055959 1056435 D formamidopyrimidine-DNA glycosylase 1055959..1056435 Mycobacterium bovis BCG str. Tokyo 172 7562030 YP_002644028.1 CDS JTY_0969 NC_012207.1 1056441 1057202 D Differs from Rv0945 by 1aa, G180R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; short chain dehydrogenase 1056441..1057202 Mycobacterium bovis BCG str. Tokyo 172 7562031 YP_002644029.1 CDS pgi NC_012207.1 1057218 1058879 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(1057218..1058879) Mycobacterium bovis BCG str. Tokyo 172 7562032 YP_002644030.1 CDS JTY_0971 NC_012207.1 1059494 1059724 R mycolyl transferase complement(1059494..1059724) Mycobacterium bovis BCG str. Tokyo 172 7562398 YP_002644031.1 CDS JTY_0972 NC_012207.1 1059840 1060157 R hypothetical protein complement(1059840..1060157) Mycobacterium bovis BCG str. Tokyo 172 7562033 YP_002644032.1 CDS uvrD1 NC_012207.1 1060454 1062769 D ATP dependent dna helicase 1060454..1062769 Mycobacterium bovis BCG str. Tokyo 172 7562034 YP_002644033.1 CDS JTY_0974 NC_012207.1 1062850 1063848 R hypothetical protein complement(1062850..1063848) Mycobacterium bovis BCG str. Tokyo 172 7561675 YP_002644034.1 CDS sucC NC_012207.1 1064158 1065321 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 1064158..1065321 Mycobacterium bovis BCG str. Tokyo 172 7562035 YP_002644035.1 CDS sucD NC_012207.1 1065334 1066245 D Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 1065334..1066245 Mycobacterium bovis BCG str. Tokyo 172 7561813 YP_002644036.1 CDS JTY_0977 NC_012207.1 1066242 1067099 R Differs from Rv0953c and Mb0978c by 1aa, A50T in Mycobacterium bovis BCG Pasteur and BCG Tokyo; oxidoreductase complement(1066242..1067099) Mycobacterium bovis BCG str. Tokyo 172 7561814 YP_002644037.1 CDS JTY_0978 NC_012207.1 1067264 1068175 D transmembrane protein 1067264..1068175 Mycobacterium bovis BCG str. Tokyo 172 7563430 YP_002644038.1 CDS JTY_0979 NC_012207.1 1068215 1069582 D integral membrane protein 1068215..1069582 Mycobacterium bovis BCG str. Tokyo 172 7563431 YP_002644039.1 CDS purN NC_012207.1 1069698 1070345 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 1069698..1070345 Mycobacterium bovis BCG str. Tokyo 172 7563432 YP_002644040.1 CDS purH NC_012207.1 1070342 1071913 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1070342..1071913 Mycobacterium bovis BCG str. Tokyo 172 7560864 YP_002644041.1 CDS JTY_0982 NC_012207.1 1072020 1073399 D Differs from Rv0958 by 1aa, P274S in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; magnesium chelatase 1072020..1073399 Mycobacterium bovis BCG str. Tokyo 172 7560860 YP_002644042.1 CDS JTY_0983 NC_012207.1 1073392 1075410 D hypothetical protein 1073392..1075410 Mycobacterium bovis BCG str. Tokyo 172 7563433 YP_002644043.1 CDS JTY_0984 NC_012207.1 1075464 1075685 D antitoxin 1075464..1075685 Mycobacterium bovis BCG str. Tokyo 172 7563434 YP_002644044.1 CDS JTY_0985 NC_012207.1 1075682 1076065 D hypothetical protein 1075682..1076065 Mycobacterium bovis BCG str. Tokyo 172 7563435 YP_002644045.1 CDS JTY_0986 NC_012207.1 1076211 1076558 D hypothetical protein 1076211..1076558 Mycobacterium bovis BCG str. Tokyo 172 7563436 YP_002644046.1 CDS lprP NC_012207.1 1076577 1077251 R Differs from Rv0962c by 1aa, L186P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein complement(1076577..1077251) Mycobacterium bovis BCG str. Tokyo 172 7563437 YP_002644047.1 CDS JTY_0988 NC_012207.1 1077434 1078234 R Differs from Rv0963c and Mb0988c by 1aa, S258G in BCG Pasteur and BCG Tokyo; hypothetical protein complement(1077434..1078234) Mycobacterium bovis BCG str. Tokyo 172 7560533 YP_002644048.1 CDS JTY_0989 NC_012207.1 1078333 1078815 R Differs from Rv0964c by 1aa, T124P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1078333..1078815) Mycobacterium bovis BCG str. Tokyo 172 7563438 YP_002644049.1 CDS JTY_0990 NC_012207.1 1078915 1079334 R Differs from Rv0965c by 1aa, H94R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1078915..1079334) Mycobacterium bovis BCG str. Tokyo 172 7563439 YP_002644050.1 CDS JTY_0991 NC_012207.1 1079370 1079972 R Differs from Rv0966c by 2aa, A175V, G186W in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1079370..1079972) Mycobacterium bovis BCG str. Tokyo 172 7563440 YP_002644051.1 CDS JTY_0992 NC_012207.1 1080111 1080470 D hypothetical protein 1080111..1080470 Mycobacterium bovis BCG str. Tokyo 172 7563441 YP_002644052.1 CDS JTY_0993 NC_012207.1 1080527 1080823 D hypothetical protein 1080527..1080823 Mycobacterium bovis BCG str. Tokyo 172 7563442 YP_002644053.1 CDS ctpV NC_012207.1 1080879 1083191 D Differs from Rv0969 by 1aa, N484D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; metal cation transporter P-type ATPase 1080879..1083191 Mycobacterium bovis BCG str. Tokyo 172 7563443 YP_002644054.1 CDS JTY_0995 NC_012207.1 1083188 1083820 D integral membrane protein 1083188..1083820 Mycobacterium bovis BCG str. Tokyo 172 7563141 YP_002644055.1 CDS echA7 NC_012207.1 1083911 1084720 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(1083911..1084720) Mycobacterium bovis BCG str. Tokyo 172 7563444 YP_002644056.1 CDS fadE12 NC_012207.1 1084720 1085886 R Differs from Rv0972c by 1aa, H236Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acyl-CoA dehydrogenase complement(1084720..1085886) Mycobacterium bovis BCG str. Tokyo 172 7561538 YP_002644057.1 CDS accA2 NC_012207.1 1085883 1087886 R Differs from Rv0973c by 1aa, F220I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acetyl-/propionyl-coenzyme A carboxylase alpha chain subunit alpha complement(1085883..1087886) Mycobacterium bovis BCG str. Tokyo 172 7563360 YP_002644058.1 CDS accD2 NC_012207.1 1087892 1089481 R Differs from Rv0974c by 1aa, K51N in Mycobacteium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo; acetyl-/propionyl-coa carboxylase subunit beta complement(1087892..1089481) Mycobacterium bovis BCG str. Tokyo 172 7564330 YP_002644059.1 CDS fadE13 NC_012207.1 1089484 1090632 R In Mycobacterium bovis, a frameshift due to a single base deletion (T-*) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG pasteur, and BCG Tokyo; acyl-CoA dehydrogenase complement(1089484..1090632) Mycobacterium bovis BCG str. Tokyo 172 7563922 YP_002644060.1 CDS JTY_1001 NC_012207.1 1090629 1092311 R hypothetical protein complement(1090629..1092311) Mycobacterium bovis BCG str. Tokyo 172 7563361 YP_002644061.1 CDS PE_PGRS16 NC_012207.1 1092510 1094003 D PE-PGRS family protein 1092510..1094003 Mycobacterium bovis BCG str. Tokyo 172 7563445 YP_002644062.1 CDS PE_PGRS16 NC_012207.1 1093960 1095282 D PE-PGRS family protein 1093960..1095282 Mycobacterium bovis BCG str. Tokyo 172 7561754 YP_002644063.1 CDS PE_PGRS17 NC_012207.1 1095499 1096506 R In Mycobacterium bovis, Mycobacterim bovis BCG Pasteur, and BCG Tokyo, a 115 bp to 127 bp substitution leads to as lightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (335 aa versus 331aa); PE-PGRS family protein complement(1095499..1096506) Mycobacterium bovis BCG str. Tokyo 172 7561755 YP_002644064.1 CDS JTY_1005 NC_012207.1 1096820 1097014 R hypothetical protein complement(1096820..1097014) Mycobacterium bovis BCG str. Tokyo 172 7561756 YP_002644065.1 CDS rpmF NC_012207.1 1097036 1097209 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1097036..1097209 Mycobacterium bovis BCG str. Tokyo 172 7563446 YP_002644066.1 CDS PE_PGRS18 NC_012207.1 1097228 1098601 R Differs from Rv0980c by 1aa, Q43H, and from Mb1006c by 1aa, A270T in Mycobacteium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo; PE-PGRS family protein complement(1097228..1098601) Mycobacterium bovis BCG str. Tokyo 172 7560719 YP_002644067.1 CDS mprA NC_012207.1 1098966 1099658 D Differs from Rv0981 by 1aa, S70G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo; persistence regulator MprA 1098966..1099658 Mycobacterium bovis BCG str. Tokyo 172 7561757 YP_002644068.1 CDS mprB NC_012207.1 1099658 1101172 D Differs from Rv0982 by 1aa, H339L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo; two component sensor kinase 1099658..1101172 Mycobacterium bovis BCG str. Tokyo 172 7563553 YP_002644069.1 CDS JTY_1010 NC_012207.1 1101216 1102610 D Differs from Rv0983 by 1aa, P390L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo; serine protease 1101216..1102610 Mycobacterium bovis BCG str. Tokyo 172 7563554 YP_002644070.1 CDS moaB2 NC_012207.1 1102610 1103155 D pterin-4-alpha-carbinolamine dehydratase 1102610..1103155 Mycobacterium bovis BCG str. Tokyo 172 7563447 YP_002644071.1 CDS mscL NC_012207.1 1103175 1103630 R forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel complement(1103175..1103630) Mycobacterium bovis BCG str. Tokyo 172 7563526 YP_002644072.1 CDS JTY_1013 NC_012207.1 1103953 1104699 D Differs from Rv0986 by 1aa, L228V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo; adhesion component transport ATP-binding protein ABC transporter 1103953..1104699 Mycobacterium bovis BCG str. Tokyo 172 7563563 YP_002644073.1 CDS JTY_1014 NC_012207.1 1104692 1107259 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, Rv0987 exists as a single gene. In Mycobacterium bovis, a single base transition (G-A) introduces a stop codon that splits Rv0987 in two parts, Mb1013 and Mb1014. Differs from Rv0987 by 1aa, V717F in BCG Pasteur and BCG Tokyo; adhesion component transport transmembrane protein ABC transporter 1104692..1107259 Mycobacterium bovis BCG str. Tokyo 172 7563448 YP_002644074.1 CDS JTY_1015 NC_012207.1 1107266 1108426 D Differs from Rv0988 by 2aa, I57V, D135Y in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; hypothetical protein 1107266..1108426 Mycobacterium bovis BCG str. Tokyo 172 7563449 YP_002644075.1 CDS grcC2 NC_012207.1 1108555 1109532 R Differs from Rv0989c by 1aa, V321I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo; polyprenyl-diphosphate synthase complement(1108555..1109532) Mycobacterium bovis BCG str. Tokyo 172 7563450 YP_002644076.1 CDS JTY_1017 NC_012207.1 1109593 1110249 R Differs from Rv0990c by 1aa, A54S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; hypothetical protein complement(1109593..1110249) Mycobacterium bovis BCG str. Tokyo 172 7563280 YP_002644077.1 CDS JTY_1018 NC_012207.1 1110322 1110654 R hypothetical protein complement(1110322..1110654) Mycobacterium bovis BCG str. Tokyo 172 7563451 YP_002644078.1 CDS JTY_1019 NC_012207.1 1110728 1111321 R Differs from Rv0992c by 2aa, I3M, S135G, and from Mb1019c by 1aa, S135G in BCG Pasteur and BCG Tokyo; hypothetical protein complement(1110728..1111321) Mycobacterium bovis BCG str. Tokyo 172 7563452 YP_002644079.1 CDS galU NC_012207.1 1111422 1112342 D Differs from Rv0993 by 1aa, R235Q in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; UTP--glucose-1-phosphate uridylyltransferase 1111422..1112342 Mycobacterium bovis BCG str. Tokyo 172 7563453 YP_002644080.1 CDS moeA1 NC_012207.1 1112419 1113699 D Differs from Rv0994 by 1aa, G230C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; molybdopterin biosynthesis protein 1112419..1113699 Mycobacterium bovis BCG str. Tokyo 172 7561901 YP_002644081.1 CDS rimJ NC_012207.1 1113762 1114373 D ribosomal-protein-alanine acetyltransferase 1113762..1114373 Mycobacterium bovis BCG str. Tokyo 172 7563539 YP_002644082.1 CDS JTY_1023 NC_012207.1 1114534 1115610 D Differs from Rv0996 by 1aa, D92G, and from Mb1023 by 1aa, D92G in BCG Pasteur, and BCG Tokyo; transmembrane protein 1114534..1115610 Mycobacterium bovis BCG str. Tokyo 172 7561579 YP_002644083.1 CDS JTY_1024 NC_012207.1 1115784 1116014 D hypothetical protein 1115784..1116014 Mycobacterium bovis BCG str. Tokyo 172 7563957 YP_002644084.1 CDS JTY_1025 NC_012207.1 1116011 1116262 D hypothetical protein 1116011..1116262 Mycobacterium bovis BCG str. Tokyo 172 7563455 YP_002644085.1 CDS JTY_1026 NC_012207.1 1116443 1116874 D hypothetical protein 1116443..1116874 Mycobacterium bovis BCG str. Tokyo 172 7563456 YP_002644086.1 CDS JTY_1027 NC_012207.1 1116898 1117899 D hypothetical protein 1116898..1117899 Mycobacterium bovis BCG str. Tokyo 172 7563457 YP_002644087.1 CDS JTY_1028 NC_012207.1 1117917 1118675 D hypothetical protein 1117917..1118675 Mycobacterium bovis BCG str. Tokyo 172 7563458 YP_002644088.1 CDS JTY_1029 NC_012207.1 1118681 1119298 R hypothetical protein complement(1118681..1119298) Mycobacterium bovis BCG str. Tokyo 172 7563459 YP_002644089.1 CDS arcA NC_012207.1 1119335 1120543 D catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 1119335..1120543 Mycobacterium bovis BCG str. Tokyo 172 7563460 YP_002644090.1 CDS JTY_1031 NC_012207.1 1120578 1122089 R Differs from Rv1002c by 1aa, L115V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; hypothetical protein complement(1120578..1122089) Mycobacterium bovis BCG str. Tokyo 172 7563982 YP_002644091.1 CDS JTY_1032 NC_012207.1 1122172 1123029 D hypothetical protein 1122172..1123029 Mycobacterium bovis BCG str. Tokyo 172 7563461 YP_002644092.1 CDS JTY_1033 NC_012207.1 1123039 1124298 R hypothetical protein complement(1123039..1124298) Mycobacterium bovis BCG str. Tokyo 172 7563462 YP_002644093.1 CDS pabB NC_012207.1 1124372 1125808 R catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; aminodeoxychorismate synthase component I complement(1124372..1125808) Mycobacterium bovis BCG str. Tokyo 172 7563463 YP_002644094.1 CDS JTY_1035 NC_012207.1 1125864 1127567 D Differs from Rv1006 by 1aa, S535P, and from Mb1033 by 1aa, N25S in BCG Pasteur and BCG Tokyo; hypothetical protein 1125864..1127567 Mycobacterium bovis BCG str. Tokyo 172 7562507 YP_002644095.1 CDS metS NC_012207.1 1127594 1129153 R methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase complement(1127594..1129153) Mycobacterium bovis BCG str. Tokyo 172 7563464 YP_002644096.1 CDS tatD NC_012207.1 1129239 1130033 D Differs from Rv1008 by 1aa, N186T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; YjjV protein; deoxyribonuclease 1129239..1130033 Mycobacterium bovis BCG str. Tokyo 172 7564463 YP_002644097.1 CDS rpfB NC_012207.1 1130241 1131329 D Differs from Rv1009 by 2aa, E282G, V357A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; resuscitation-promoting factor 1130241..1131329 Mycobacterium bovis BCG str. Tokyo 172 7561826 YP_002644098.1 CDS ksgA NC_012207.1 1131302 1132255 D catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1131302..1132255 Mycobacterium bovis BCG str. Tokyo 172 7561597 YP_002644099.1 CDS ispE NC_012207.1 1132341 1133261 D catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1132341..1133261 Mycobacterium bovis BCG str. Tokyo 172 7562809 YP_002644100.1 CDS JTY_1041 NC_012207.1 1133258 1133572 D In Mycobacterium tuberculosis strain H37Rv, Rv1012 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-G) leads to a different NH2 terminus. Differs from Rv1012 by 1aa, N65S; hypothetical protein 1133258..1133572 Mycobacterium bovis BCG str. Tokyo 172 7562795 YP_002644101.1 CDS pks16 NC_012207.1 1133776 1135410 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1133776..1135410 Mycobacterium bovis BCG str. Tokyo 172 7563465 YP_002644102.1 CDS pth NC_012207.1 1135484 1136059 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(1135484..1136059) Mycobacterium bovis BCG str. Tokyo 172 7562445 YP_002644103.1 CDS rplY NC_012207.1 1136072 1136719 R the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 complement(1136072..1136719) Mycobacterium bovis BCG str. Tokyo 172 7560851 YP_002644104.1 CDS lpqT NC_012207.1 1136853 1137611 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a 5 bp deletion (CACGC-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; lipoprotein complement(1136853..1137611) Mycobacterium bovis BCG str. Tokyo 172 7560712 YP_002644105.1 CDS prsA NC_012207.1 1137647 1138627 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1137647..1138627) Mycobacterium bovis BCG str. Tokyo 172 7560512 YP_002644106.1 CDS glmU NC_012207.1 1138719 1140206 R forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase complement(1138719..1140206) Mycobacterium bovis BCG str. Tokyo 172 7560837 YP_002644107.1 CDS JTY_1048 NC_012207.1 1140461 1141054 D probably TetR-family; transcriptional regulatory protein 1140461..1141054 Mycobacterium bovis BCG str. Tokyo 172 7561935 YP_002644108.1 CDS mfd NC_012207.1 1141113 1144817 D transcription-repair coupling factor 1141113..1144817 Mycobacterium bovis BCG str. Tokyo 172 7563466 YP_002644109.1 CDS JTY_1050 NC_012207.1 1144817 1145794 D functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 1144817..1145794 Mycobacterium bovis BCG str. Tokyo 172 7564470 YP_002644110.1 CDS lpqU NC_012207.1 1145882 1146613 D Differs from Rv1022 by 1aa, P33T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 1145882..1146613 Mycobacterium bovis BCG str. Tokyo 172 7563467 YP_002644111.1 CDS eno NC_012207.1 1146710 1147999 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1146710..1147999 Mycobacterium bovis BCG str. Tokyo 172 7560513 YP_002644112.1 CDS JTY_1053 NC_012207.1 1148004 1148690 D hypothetical protein 1148004..1148690 Mycobacterium bovis BCG str. Tokyo 172 7562865 YP_002644113.1 CDS JTY_1054 NC_012207.1 1148707 1149174 D hypothetical protein 1148707..1149174 Mycobacterium bovis BCG str. Tokyo 172 7563468 YP_002644114.1 CDS JTY_1055 NC_012207.1 1149165 1150124 D hypothetical protein 1149165..1150124 Mycobacterium bovis BCG str. Tokyo 172 7563469 YP_002644115.1 CDS kdpE NC_012207.1 1150573 1151253 R transcriptional regulatory protein complement(1150573..1151253) Mycobacterium bovis BCG str. Tokyo 172 7563470 YP_002644116.1 CDS kdpD NC_012207.1 1151250 1153832 R Differs from Rv1028c by 3aa, S83P, D295G, S368P, and from Mb1056c by 1aa, S83P in BCG Pasteur and BCG Tokyo; sensor protein complement(1151250..1153832) Mycobacterium bovis BCG str. Tokyo 172 7562805 YP_002644117.1 CDS kdpF NC_012207.1 1154066 1154158 D hypothetical protein 1154066..1154158 Mycobacterium bovis BCG str. Tokyo 172 7562804 YP_002644118.1 CDS kdpA NC_012207.1 1154158 1155873 D catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 1154158..1155873 Mycobacterium bovis BCG str. Tokyo 172 7562806 YP_002644119.1 CDS kdpB NC_012207.1 1155870 1157999 D One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 1155870..1157999 Mycobacterium bovis BCG str. Tokyo 172 7562801 YP_002644120.1 CDS kdpC NC_012207.1 1157999 1158568 D one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 1157999..1158568 Mycobacterium bovis BCG str. Tokyo 172 7562802 YP_002644121.1 CDS trcS NC_012207.1 1158572 1160101 R two component sensor histidine kinase complement(1158572..1160101) Mycobacterium bovis BCG str. Tokyo 172 7562803 YP_002644122.1 CDS trcR NC_012207.1 1160109 1160882 R two component transcriptional regulator complement(1160109..1160882) Mycobacterium bovis BCG str. Tokyo 172 7561867 YP_002644123.1 CDS JTY_1064 NC_012207.1 1161064 1161453 R transposase complement(1161064..1161453) Mycobacterium bovis BCG str. Tokyo 172 7561866 YP_002644124.1 CDS JTY_1065 NC_012207.1 1161521 1162207 R transposase complement(1161521..1162207) Mycobacterium bovis BCG str. Tokyo 172 7563471 YP_002644125.1 CDS JTY_1066 NC_012207.1 1162241 1162579 R IS1560 transposase complement(1162241..1162579) Mycobacterium bovis BCG str. Tokyo 172 7563472 YP_002644126.1 CDS esxI NC_012207.1 1162690 1162974 R Differs from Rv1037c by 1aa, L20Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; EsaT-6 like protein 1 complement(1162690..1162974) Mycobacterium bovis BCG str. Tokyo 172 7563473 YP_002644127.1 CDS esxJ NC_012207.1 1163001 1163297 R EsaT-6 like protein 2 complement(1163001..1163297) Mycobacterium bovis BCG str. Tokyo 172 7562880 YP_002644128.1 CDS PPE15 NC_012207.1 1163443 1164618 R Differs from Rv1039c and Mb1068c by 1aa, K175N in BCG Pasteur and BCG Tokyo; PPE family protein complement(1163443..1164618) Mycobacterium bovis BCG str. Tokyo 172 7562881 YP_002644129.1 CDS PE8 NC_012207.1 1164695 1165522 R PE family protein complement(1164695..1165522) Mycobacterium bovis BCG str. Tokyo 172 7562150 YP_002644130.1 CDS JTY_1072 NC_012207.1 1167238 1167645 R Differs from Rv1042c by 1aa, E129G in Mycobacterium bovis and BCG Pasteur. Differs from Mb1070c by G129E in Mycobacterium tuberculosis and Mycobacterium bovis BCG Tokyo; IS like-2 transposase complement(1167238..1167645) Mycobacterium bovis BCG str. Tokyo 172 7563474 YP_002644131.1 CDS JTY_1073 NC_012207.1 1167928 1168953 R Differs from Rv1043c by 1aa, T99A, and from Mb1072c by 1aa, G263C in BCG Pasteur and BCG Tokyo; hypothetical protein complement(1167928..1168953) Mycobacterium bovis BCG str. Tokyo 172 7563475 YP_002644132.1 CDS JTY_1074 NC_012207.1 1169200 1169823 D hypothetical protein 1169200..1169823 Mycobacterium bovis BCG str. Tokyo 172 7563476 YP_002644133.1 CDS JTY_1075 NC_012207.1 1169820 1170701 D Differs from Mb1074 by 1aa, W104G in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein 1169820..1170701 Mycobacterium bovis BCG str. Tokyo 172 7563477 YP_002644134.1 CDS JTY_1076 NC_012207.1 1170783 1171376 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 1bp insertion, compared to Mycobacterium tuberculosis strains H37Rv, leads to different C-terminus; hypothetical protein complement(1170783..1171376) Mycobacterium bovis BCG str. Tokyo 172 7563478 YP_002644135.1 CDS JTY_1077 NC_012207.1 1171571 1172818 D IS1081 transposase 1171571..1172818 Mycobacterium bovis BCG str. Tokyo 172 7563479 YP_002644136.1 CDS JTY_1078 NC_012207.1 1173186 1174301 R Differs from Rv1048c and Mb1077c by 2aa, A37D, T173A in BCG Pasteur and BCG Tokyo.; hypothetical protein complement(1173186..1174301) Mycobacterium bovis BCG str. Tokyo 172 7563480 YP_002644137.1 CDS JTY_1079 NC_012207.1 1174534 1174980 D transcriptional repressor protein 1174534..1174980 Mycobacterium bovis BCG str. Tokyo 172 7563481 YP_002644138.1 CDS JTY_1080 NC_012207.1 1175028 1175933 D oxidoreductase 1175028..1175933 Mycobacterium bovis BCG str. Tokyo 172 7563482 YP_002644139.1 CDS JTY_1081 NC_012207.1 1176092 1176847 R hypothetical protein complement(1176092..1176847) Mycobacterium bovis BCG str. Tokyo 172 7563483 YP_002644140.1 CDS JTY_1082 NC_012207.1 1177870 1178259 D hypothetical protein 1177870..1178259 Mycobacterium bovis BCG str. Tokyo 172 7563484 YP_002644141.1 CDS JTY_1083 NC_012207.1 1178158 1178433 R hypothetical protein complement(1178158..1178433) Mycobacterium bovis BCG str. Tokyo 172 7563485 YP_002644142.1 CDS JTY_1084 NC_012207.1 1179075 1179389 D integrase 1179075..1179389 Mycobacterium bovis BCG str. Tokyo 172 7563486 YP_002644143.1 CDS JTY_1085 NC_012207.1 1179386 1179520 D integrase 1179386..1179520 Mycobacterium bovis BCG str. Tokyo 172 7563487 YP_002644144.1 CDS JTY_1086 NC_012207.1 1179775 1180539 D hypothetical protein 1179775..1180539 Mycobacterium bovis BCG str. Tokyo 172 7562822 YP_002644145.1 CDS JTY_1087 NC_012207.1 1181543 1182724 D hypothetical protein 1181543..1182724 Mycobacterium bovis BCG str. Tokyo 172 7563489 YP_002644146.1 CDS fadD14 NC_012207.1 1182831 1184462 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1182831..1184462 Mycobacterium bovis BCG str. Tokyo 172 7563490 YP_002644147.1 CDS JTY_1089 NC_012207.1 1184538 1185602 D hypothetical protein 1184538..1185602 Mycobacterium bovis BCG str. Tokyo 172 7562920 YP_002644148.1 CDS JTY_1090 NC_012207.1 1185655 1186128 D hypothetical protein 1185655..1186128 Mycobacterium bovis BCG str. Tokyo 172 7563491 YP_002644149.1 CDS JTY_1091 NC_012207.1 1186162 1187025 D hypothetical protein 1186162..1187025 Mycobacterium bovis BCG str. Tokyo 172 7563492 YP_002644150.1 CDS JTY_1092 NC_012207.1 1187030 1187887 D hypothetical protein 1187030..1187887 Mycobacterium bovis BCG str. Tokyo 172 7563493 YP_002644151.1 CDS JTY_1093 NC_012207.1 1187888 1188970 R hypothetical protein complement(1187888..1188970) Mycobacterium bovis BCG str. Tokyo 172 7563494 YP_002644152.1 CDS lpqV NC_012207.1 1189051 1189470 R lipoprotein complement(1189051..1189470) Mycobacterium bovis BCG str. Tokyo 172 7563495 YP_002644153.1 CDS JTY_1095 NC_012207.1 1189582 1190148 D hypothetical protein 1189582..1190148 Mycobacterium bovis BCG str. Tokyo 172 7560514 YP_002644154.1 CDS JTY_1096 NC_012207.1 1190145 1190540 D hypothetical protein 1190145..1190540 Mycobacterium bovis BCG str. Tokyo 172 7563496 YP_002644155.1 CDS PE_PGRS19 NC_012207.1 1190568 1192583 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, 2 deletions each of 3 bp (CCG-* and CGC-*) and a 18 bp insertion leads to a longer product compared to their homolog in Mycobacterium tuberculosis strain H37Rv (671 aa versus 667 aa); PE-PGRS family protein complement(1190568..1192583) Mycobacterium bovis BCG str. Tokyo 172 7563497 YP_002644156.1 CDS PE_PGRS20.1 NC_012207.1 1192916 1193530 R In Mycobacterium bovis, insertions of 717 bp and 192 bp, and a 9 bp (TCCGCTGCC-*) deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (763 aa versus 463 aa). In Mycobacterium bovis BCG Pasteur a deletion of 99 bp leads to a smaller product compared to the homolog in Mycobacterium bovis (730 aa versus 763 aa). Mycobacterium bovis BCG Tokyo a deletion of 323 bp from BCG Pasteur leads to two products (204 aa, 401 aa); PE-PGRS family protein complement(1192916..1193530) Mycobacterium bovis BCG str. Tokyo 172 7561758 YP_002644157.1 CDS PE_PGRS20.2 NC_012207.1 1193553 1194758 R In Mycobacterium bovis, insertions of 717 bp and 192 bp, and a 9 bp (tccgctgcc-*) deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (763 aa versus 463 aa). In Mycobacterium bovis BCG Pasteur a deletion of 99 bp leads to a smaller product compared to the homolog in Mycobacterium bovis (730 aa versus 763 aa). Mycobacterium bovis BCG Tokyo a deletion of 323 bp from BCG Pasteur leads to two products (204 aa, 401 aa); PE-PGRS family protein complement(1193553..1194758) Mycobacterium bovis BCG str. Tokyo 172 7561760 YP_002644158.1 CDS JTY_1100 NC_012207.1 1195147 1196910 R Differs from Rv1069c and from Mb1098c by 1aa L481P in BCG Pasteur and BCG Tokyo.; hypothetical protein complement(1195147..1196910) Mycobacterium bovis BCG str. Tokyo 172 7561761 YP_002644159.1 CDS echA8 NC_012207.1 1196907 1197680 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(1196907..1197680) Mycobacterium bovis BCG str. Tokyo 172 7563498 YP_002644160.1 CDS echA9 NC_012207.1 1197692 1198729 R catalyzes the formation of 3-hydroxy-2-methylpropanoate from 3-hydroxy-2-methylpropanoyl-CoA; 3-hydroxyisobutyryl-CoA hydrolase complement(1197692..1198729) Mycobacterium bovis BCG str. Tokyo 172 7561539 YP_002644161.1 CDS JTY_1103 NC_012207.1 1198916 1199752 D transmembrane protein 1198916..1199752 Mycobacterium bovis BCG str. Tokyo 172 7561540 YP_002644162.1 CDS JTY_1104 NC_012207.1 1199868 1200719 D hypothetical protein 1199868..1200719 Mycobacterium bovis BCG str. Tokyo 172 7563499 YP_002644163.1 CDS fadA3 NC_012207.1 1200793 1202010 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(1200793..1202010) Mycobacterium bovis BCG str. Tokyo 172 7563500 YP_002644164.1 CDS JTY_1106 NC_012207.1 1202063 1203007 R conserved exported protein complement(1202063..1203007) Mycobacterium bovis BCG str. Tokyo 172 7562906 YP_002644165.1 CDS lipU NC_012207.1 1203404 1204297 D lipase 1203404..1204297 Mycobacterium bovis BCG str. Tokyo 172 7563501 YP_002644166.1 CDS cbs NC_012207.1 1204354 1205748 D cystathionine beta-synthase 1204354..1205748 Mycobacterium bovis BCG str. Tokyo 172 7562847 YP_002644167.1 CDS pra NC_012207.1 1205950 1206672 D Differs from Rv1078 by 1aa T171I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; proline-rich antigen homolog 1205950..1206672 Mycobacterium bovis BCG str. Tokyo 172 7562084 YP_002644168.1 CDS metB NC_012207.1 1206704 1207870 D catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 1206704..1207870 Mycobacterium bovis BCG str. Tokyo 172 7560818 YP_002644169.1 CDS greA NC_012207.1 1207941 1208435 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(1207941..1208435) Mycobacterium bovis BCG str. Tokyo 172 7564458 YP_002644170.1 CDS JTY_1112 NC_012207.1 1208621 1209055 R hypothetical protein complement(1208621..1209055) Mycobacterium bovis BCG str. Tokyo 172 7563281 YP_002644171.1 CDS mca NC_012207.1 1209157 1210023 D mycothiol conjugate amidase 1209157..1210023 Mycobacterium bovis BCG str. Tokyo 172 7563502 YP_002644172.1 CDS JTY_1114 NC_012207.1 1210020 1210286 D hypothetical protein 1210020..1210286 Mycobacterium bovis BCG str. Tokyo 172 7564431 YP_002644173.1 CDS JTY_1115 NC_012207.1 1210273 1212294 D hypothetical protein 1210273..1212294 Mycobacterium bovis BCG str. Tokyo 172 7563503 YP_002644174.1 CDS JTY_1116 NC_012207.1 1212393 1213121 R hemolysin-like protein complement(1212393..1213121) Mycobacterium bovis BCG str. Tokyo 172 7563504 YP_002644175.1 CDS JTY_1117 NC_012207.1 1213232 1214020 D short (C15) chain Z-isoprenyl diphosphate synthase 1213232..1214020 Mycobacterium bovis BCG str. Tokyo 172 7563505 YP_002644176.1 CDS PE_PGRS21 NC_012207.1 1214197 1216626 D In Mycobacterium bovis BCG Pasteur and Tokyo, insertions of 144 bp and 3 bp, and deletion of 42 bp, lead to a longer product compared to the homolog in Mycobacterium bovis (809 aa versus 774 aa). In Mycobacterium bovis, insertions of 3 bp (*-GCG) and 45 bp, and deletions of 18 bp and 9 bp (GGTGGGGCC-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (774 aa versus 767 aa); PE-PGRS family protein 1214197..1216626 Mycobacterium bovis BCG str. Tokyo 172 7563506 YP_002644177.1 CDS JTY_1119 NC_012207.1 1216803 1217123 D hypothetical protein 1216803..1217123 Mycobacterium bovis BCG str. Tokyo 172 7561762 YP_002644178.1 CDS PE9 NC_012207.1 1217276 1217710 D PE family protein 1217276..1217710 Mycobacterium bovis BCG str. Tokyo 172 7563507 YP_002644179.1 CDS PE10 NC_012207.1 1217589 1217894 D Differs from Rv1089 and Mb1118 by 1 aa N84T in BCG Pasteur and BCG Tokyo; PE family protein 1217589..1217894 Mycobacterium bovis BCG str. Tokyo 172 7561740 YP_002644180.1 CDS celA2a NC_012207.1 1218280 1218384 D cellulase 1218280..1218384 Mycobacterium bovis BCG str. Tokyo 172 7561710 YP_002644181.1 CDS celA2b NC_012207.1 1218362 1218817 D cellulase 1218362..1218817 Mycobacterium bovis BCG str. Tokyo 172 7562093 YP_002644182.1 CDS PE_PGRS22 NC_012207.1 1219232 1221784 D In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 9 bp deletion (CCGGCGGCA-*) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (850 aa versus 853 aa); PE-PGRS family protein 1219232..1221784 Mycobacterium bovis BCG str. Tokyo 172 7562094 YP_002644183.1 CDS coaA NC_012207.1 1222002 1222940 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(1222002..1222940) Mycobacterium bovis BCG str. Tokyo 172 7561763 YP_002644184.1 CDS glyA NC_012207.1 1223328 1224608 D catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 1223328..1224608 Mycobacterium bovis BCG str. Tokyo 172 7562117 YP_002644185.1 CDS desA2 NC_012207.1 1224713 1225540 D acyl-ACP desaturase 1224713..1225540 Mycobacterium bovis BCG str. Tokyo 172 7561952 YP_002644186.1 CDS phoH2 NC_012207.1 1225751 1227052 D phoH-like protein 1225751..1227052 Mycobacterium bovis BCG str. Tokyo 172 7561484 YP_002644187.1 CDS JTY_1129 NC_012207.1 1227139 1228014 D Differs from Rv1096 by 1aa, S272P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; glycosyl hydrolase 1227139..1228014 Mycobacterium bovis BCG str. Tokyo 172 7562410 YP_002644188.1 CDS JTY_1130 NC_012207.1 1228017 1228898 R Differs from Rv1097c by 1aa, L23P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; membrane glycine and proline rich protein complement(1228017..1228898) Mycobacterium bovis BCG str. Tokyo 172 7563508 YP_002644189.1 CDS fumC NC_012207.1 1228895 1230319 R class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase complement(1228895..1230319) Mycobacterium bovis BCG str. Tokyo 172 7563509 YP_002644190.1 CDS glpX NC_012207.1 1230350 1231336 R type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II complement(1230350..1231336) Mycobacterium bovis BCG str. Tokyo 172 7561885 YP_002644191.1 CDS JTY_1133 NC_012207.1 1231437 1232138 D Differs from Rv1100 and Mb1130 by 1aa, P21T in BCG Pasteur and BCG Tokyo; hypothetical protein 1231437..1232138 Mycobacterium bovis BCG str. Tokyo 172 7561944 YP_002644192.1 CDS JTY_1134 NC_012207.1 1232145 1233173 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (T-*) leads to a shorter product with a different amino part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Mb1131c by 1 aa, E315D in BCG Pasteur and BCG Tokyo; hypothetical protein complement(1232145..1233173) Mycobacterium bovis BCG str. Tokyo 172 7563510 YP_002644193.1 CDS JTY_1135 NC_012207.1 1233413 1233724 R Differs from Rv1102c by 1aa, I65T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1233413..1233724) Mycobacterium bovis BCG str. Tokyo 172 7563511 YP_002644194.1 CDS JTY_1136 NC_012207.1 1233724 1234044 R hypothetical protein complement(1233724..1234044) Mycobacterium bovis BCG str. Tokyo 172 7562528 YP_002644195.1 CDS JTY_1137 NC_012207.1 1234054 1234743 D para-nitrobenzyl esterase 1234054..1234743 Mycobacterium bovis BCG str. Tokyo 172 7562529 YP_002644196.1 CDS JTY_1138 NC_012207.1 1235064 1235579 D para-nitrobenzyl esterase 1235064..1235579 Mycobacterium bovis BCG str. Tokyo 172 7562530 YP_002644197.1 CDS JTY_1139 NC_012207.1 1235597 1236709 R cholesterol dehydrogenase complement(1235597..1236709) Mycobacterium bovis BCG str. Tokyo 172 7562531 YP_002644198.1 CDS xseB NC_012207.1 1236719 1236976 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(1236719..1236976) Mycobacterium bovis BCG str. Tokyo 172 7562532 YP_002644199.1 CDS xseA NC_012207.1 1236966 1238213 R bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit complement(1236966..1238213) Mycobacterium bovis BCG str. Tokyo 172 7561699 YP_002644200.1 CDS JTY_1142 NC_012207.1 1238210 1238848 R Differs from Rv1109c and Mb1139c by 1aa, T147A in BCG Pasteur and BCG Tokyo; hypothetical protein complement(1238210..1238848) Mycobacterium bovis BCG str. Tokyo 172 7561698 YP_002644201.1 CDS ispH NC_012207.1 1238938 1239945 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1238938..1239945 Mycobacterium bovis BCG str. Tokyo 172 7562533 YP_002644202.1 CDS JTY_1144 NC_012207.1 1239962 1240945 R hypothetical protein complement(1239962..1240945) Mycobacterium bovis BCG str. Tokyo 172 7560545 YP_002644203.1 CDS ychF NC_012207.1 1241008 1242081 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1241008..1242081 Mycobacterium bovis BCG str. Tokyo 172 7562534 YP_002644204.1 CDS JTY_1146 NC_012207.1 1242169 1242366 D hypothetical protein 1242169..1242366 Mycobacterium bovis BCG str. Tokyo 172 7561703 YP_002644205.1 CDS JTY_1147 NC_012207.1 1242363 1242737 D hypothetical protein 1242363..1242737 Mycobacterium bovis BCG str. Tokyo 172 7562535 YP_002644206.1 CDS JTY_1148 NC_012207.1 1242940 1243638 D Differs from Rv1115 by 1aa, P19S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1242940..1243638 Mycobacterium bovis BCG str. Tokyo 172 7562536 YP_002644207.1 CDS JTY_1149 NC_012207.1 1243756 1243941 D hypothetical protein 1243756..1243941 Mycobacterium bovis BCG str. Tokyo 172 7562537 YP_002644208.1 CDS JTY_1150 NC_012207.1 1243868 1244143 R hypothetical protein complement(1243868..1244143) Mycobacterium bovis BCG str. Tokyo 172 7562538 YP_002644209.1 CDS JTY_1151 NC_012207.1 1244386 1244709 D hypothetical protein 1244386..1244709 Mycobacterium bovis BCG str. Tokyo 172 7562539 YP_002644210.1 CDS JTY_1152 NC_012207.1 1244724 1245584 R hypothetical protein complement(1244724..1245584) Mycobacterium bovis BCG str. Tokyo 172 7562540 YP_002644211.1 CDS JTY_1153 NC_012207.1 1245617 1245766 R hypothetical protein complement(1245617..1245766) Mycobacterium bovis BCG str. Tokyo 172 7562541 YP_002644212.1 CDS JTY_1154 NC_012207.1 1245763 1246257 R Differs from Mb1151c by 1aa, G53A in BCG Pasteur and BCG Tokyo; hypothetical protein complement(1245763..1246257) Mycobacterium bovis BCG str. Tokyo 172 7562542 YP_002644213.1 CDS zwf1 NC_012207.1 1246460 1247860 D catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1246460..1247860 Mycobacterium bovis BCG str. Tokyo 172 7562543 YP_002644214.1 CDS gnd2 NC_012207.1 1247882 1248904 D similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; 6-phosphogluconate dehydrogenase 1247882..1248904 Mycobacterium bovis BCG str. Tokyo 172 7561457 YP_002644215.1 CDS bpoB NC_012207.1 1248897 1249805 R non-haem peroxidase; peroxidase complement(1248897..1249805) Mycobacterium bovis BCG str. Tokyo 172 7563273 YP_002644216.1 CDS ephC NC_012207.1 1249880 1250830 D epoxide hydrolase 1249880..1250830 Mycobacterium bovis BCG str. Tokyo 172 7562077 YP_002644217.1 CDS JTY_1159 NC_012207.1 1250835 1252079 D Differs from Rv1125 by 1aa, G101S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1250835..1252079 Mycobacterium bovis BCG str. Tokyo 172 7562868 YP_002644218.1 CDS JTY_1160 NC_012207.1 1252083 1252688 R hypothetical protein complement(1252083..1252688) Mycobacterium bovis BCG str. Tokyo 172 7562544 YP_002644219.1 CDS ppdK NC_012207.1 1252685 1254157 R catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase complement(1252685..1254157) Mycobacterium bovis BCG str. Tokyo 172 7562545 YP_002644220.1 CDS JTY_1162 NC_012207.1 1254370 1255725 R Differs from Rv1128c by 1aa, G270E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1254370..1255725) Mycobacterium bovis BCG str. Tokyo 172 7562143 YP_002644221.1 CDS JTY_1163 NC_012207.1 1255827 1257287 R transcriptional regulator protein complement(1255827..1257287) Mycobacterium bovis BCG str. Tokyo 172 7562546 YP_002644222.1 CDS JTY_1164 NC_012207.1 1257308 1258888 D Differs from Rv1130 by 2aa, G3D, L10F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1257308..1258888 Mycobacterium bovis BCG str. Tokyo 172 7562547 YP_002644223.1 CDS gltA1 NC_012207.1 1258885 1260066 D catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; citrate synthase 1258885..1260066 Mycobacterium bovis BCG str. Tokyo 172 7562548 YP_002644224.1 CDS JTY_1166 NC_012207.1 1260078 1261808 D Differs from Mb1163 by 1aa, T176M in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1260078..1261808 Mycobacterium bovis BCG str. Tokyo 172 7561946 YP_002644225.1 CDS metE NC_012207.1 1261820 1264099 R catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase complement(1261820..1264099) Mycobacterium bovis BCG str. Tokyo 172 7562549 YP_002644226.1 CDS JTY_1168 NC_012207.1 1264675 1264911 D hypothetical protein 1264675..1264911 Mycobacterium bovis BCG str. Tokyo 172 7564460 YP_002644227.1 CDS PPE16 NC_012207.1 1265025 1266881 R PPE family protein complement(1265025..1266881) Mycobacterium bovis BCG str. Tokyo 172 7562550 YP_002644228.1 CDS JTY_1170 NC_012207.1 1267067 1267309 D acetyl-CoA acetyltransferase 1267067..1267309 Mycobacterium bovis BCG str. Tokyo 172 7562151 YP_002644229.1 CDS JTY_1171 NC_012207.1 1267359 1267700 D enoyl-CoA hydratase 1267359..1267700 Mycobacterium bovis BCG str. Tokyo 172 7562551 YP_002644230.1 CDS JTY_1172 NC_012207.1 1267840 1268208 R hypothetical protein complement(1267840..1268208) Mycobacterium bovis BCG str. Tokyo 172 7562552 YP_002644231.1 CDS JTY_1173 NC_012207.1 1268225 1269241 R oxidoreductase complement(1268225..1269241) Mycobacterium bovis BCG str. Tokyo 172 7562553 YP_002644232.1 CDS JTY_1174 NC_012207.1 1269238 1269738 R hypothetical protein complement(1269238..1269738) Mycobacterium bovis BCG str. Tokyo 172 7562554 YP_002644233.1 CDS JTY_1175 NC_012207.1 1270100 1270948 D integral membrane protein 1270100..1270948 Mycobacterium bovis BCG str. Tokyo 172 7562555 YP_002644234.1 CDS echA11 NC_012207.1 1270956 1271762 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(1270956..1271762) Mycobacterium bovis BCG str. Tokyo 172 7562556 YP_002644235.1 CDS echA10 NC_012207.1 1271905 1272711 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(1271905..1272711) Mycobacterium bovis BCG str. Tokyo 172 7561523 YP_002644236.1 CDS mcr NC_012207.1 1272815 1273897 D alpha-methylacyl-CoA racemase 1272815..1273897 Mycobacterium bovis BCG str. Tokyo 172 7561522 YP_002644237.1 CDS JTY_1179 NC_012207.1 1273909 1274661 D short-chain type dehydrogenase/reductase 1273909..1274661 Mycobacterium bovis BCG str. Tokyo 172 7564447 YP_002644238.1 CDS mmpL13 NC_012207.1 1275176 1277521 D In Mycobacterium tuberculosis strain H37Rv, Rv1145 and Rv1146 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-A) at H37Rv position 1273250-1273251 leads to a single product; transmembrane transport protein 1275176..1277521 Mycobacterium bovis BCG str. Tokyo 172 7562557 YP_002644239.1 CDS JTY_1181 NC_012207.1 1277654 1278304 D hypothetical protein 1277654..1278304 Mycobacterium bovis BCG str. Tokyo 172 7564483 YP_002644240.1 CDS JTY_1182 NC_012207.1 1279054 1280502 R Differs from Rv1148c and Mb1179c by 1aa, N354H in BCG Pasteur and BCG Tokyo; hypothetical protein complement(1279054..1280502) Mycobacterium bovis BCG str. Tokyo 172 7562558 YP_002644241.1 CDS JTY_1183 NC_012207.1 1280647 1281054 D transposase 1280647..1281054 Mycobacterium bovis BCG str. Tokyo 172 7562559 YP_002644242.1 CDS JTY_1185 NC_012207.1 1281658 1282371 R Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase complement(1281658..1282371) Mycobacterium bovis BCG str. Tokyo 172 7562561 YP_002644243.1 CDS JTY_1186 NC_012207.1 1282409 1282774 D transcriptional regulatory protein 1282409..1282774 Mycobacterium bovis BCG str. Tokyo 172 7562562 YP_002644244.1 CDS omt NC_012207.1 1282752 1283600 R Differs from Rv1153c by 2aa, T36A, G53D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; O-methyltransferase complement(1282752..1283600) Mycobacterium bovis BCG str. Tokyo 172 7562563 YP_002644245.1 CDS JTY_1188 NC_012207.1 1283597 1284238 R Differs from Rv1154c by 1aa, A123T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1283597..1284238) Mycobacterium bovis BCG str. Tokyo 172 7562494 YP_002644246.1 CDS JTY_1189 NC_012207.1 1284183 1284626 D Differs from Rv1155 by 1aa, P115S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1284183..1284626 Mycobacterium bovis BCG str. Tokyo 172 7562564 YP_002644247.1 CDS JTY_1190 NC_012207.1 1285060 1285647 D hypothetical protein 1285060..1285647 Mycobacterium bovis BCG str. Tokyo 172 7562565 YP_002644248.1 CDS JTY_1191 NC_012207.1 1285810 1286853 R Is 24 codons shorter than Rv1157c and Mb1188c due to 72bp deletion at position equivalent to H37Rv, 1283458-1283529. After codon 214; hypothetical ala-, pro-rich protein complement(1285810..1286853) Mycobacterium bovis BCG str. Tokyo 172 7562566 YP_002644249.1 CDS JTY_1192 NC_012207.1 1286861 1287544 R hypothetical ala-, pro-rich protein complement(1286861..1287544) Mycobacterium bovis BCG str. Tokyo 172 7562567 YP_002644250.1 CDS pimE NC_012207.1 1287674 1288969 D involved in the fifth mannose transfer of phosphatidylinositol mannoside synthesis; mannosyltransferase 1287674..1288969 Mycobacterium bovis BCG str. Tokyo 172 7562568 YP_002644251.1 CDS phhB NC_012207.1 1288966 1289250 R 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction; pterin-4-alpha-carbinolamine dehydratase complement(1288966..1289250) Mycobacterium bovis BCG str. Tokyo 172 7562423 YP_002644252.1 CDS mutT2 NC_012207.1 1289277 1289702 D mutator protein 1289277..1289702 Mycobacterium bovis BCG str. Tokyo 172 7562408 YP_002644253.1 CDS narG NC_012207.1 1290010 1293708 D Differs from Rv1161 by 2aa, L458V, G821D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; respiratory nitrate reductase alpha chain 1290010..1293708 Mycobacterium bovis BCG str. Tokyo 172 7563582 YP_002644254.1 CDS narH NC_012207.1 1293747 1295423 D respiratory nitrate reductase subunit beta 1293747..1295423 Mycobacterium bovis BCG str. Tokyo 172 7563593 YP_002644255.1 CDS narJ NC_012207.1 1295480 1296085 D Differs from Rv1163 and Mb1195 by 1aa, L106P in Mycobacterium bovis BCG Pasteur.; respiratory nitrate reductase delta chain 1295480..1296085 Mycobacterium bovis BCG str. Tokyo 172 7562446 YP_002644256.1 CDS narI NC_012207.1 1296088 1296828 D Differs from Rv1164 by 1aa, V200A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; respiratory nitrate reductase gamma chain 1296088..1296828 Mycobacterium bovis BCG str. Tokyo 172 7562448 YP_002644257.1 CDS typA NC_012207.1 1296850 1298736 D Differs from Rv1165, Mb1197 by 1aa L98V in Mycobacterium bovis BCG Tokyo.; GTP-binding translation elongation factor 1296850..1298736 Mycobacterium bovis BCG str. Tokyo 172 7562447 YP_002644258.1 CDS lpqW NC_012207.1 1298834 1300741 D lipoprotein 1298834..1300741 Mycobacterium bovis BCG str. Tokyo 172 7561645 YP_002644259.1 CDS JTY_1202 NC_012207.1 1300769 1301374 R transcriptional regulatory protein complement(1300769..1301374) Mycobacterium bovis BCG str. Tokyo 172 7560515 YP_002644260.1 CDS PPE17a NC_012207.1 1301945 1302487 R In Mycobacterium tuberculosis strain H37Rv, PPE17 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-C) splits PPE17 into 2 parts, PPE17a and PPE17b; PPE Family protein complement(1301945..1302487) Mycobacterium bovis BCG str. Tokyo 172 7562153 YP_002644261.1 CDS PE11 NC_012207.1 1302505 1302807 R PE family protein complement(1302505..1302807) Mycobacterium bovis BCG str. Tokyo 172 7562152 YP_002644262.1 CDS mshB NC_012207.1 1302987 1303898 D N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha- D-Glucopyranoside deacetylase 1302987..1303898 Mycobacterium bovis BCG str. Tokyo 172 7561711 YP_002644263.1 CDS JTY_1207 NC_012207.1 1303990 1304430 D hypothetical protein 1303990..1304430 Mycobacterium bovis BCG str. Tokyo 172 7563564 YP_002644264.1 CDS PE12 NC_012207.1 1304438 1305364 R Differs from Rv1172c by 1aa, H133Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PE family protein complement(1304438..1305364) Mycobacterium bovis BCG str. Tokyo 172 7562570 YP_002644265.1 CDS fbiC NC_012207.1 1305614 1308184 D 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; FO synthase 1305614..1308184 Mycobacterium bovis BCG str. Tokyo 172 7561712 YP_002644266.1 CDS JTY_1210 NC_012207.1 1308290 1308622 R hypothetical protein complement(1308290..1308622) Mycobacterium bovis BCG str. Tokyo 172 7563399 YP_002644267.1 CDS fadH NC_012207.1 1308823 1310847 R Differs from Rv1175c by 3aa, N90T, S210T, S649I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; NADPH dependent 2,4-dienoyl-CoA reductase complement(1308823..1310847) Mycobacterium bovis BCG str. Tokyo 172 7562571 YP_002644268.1 CDS JTY_1212 NC_012207.1 1310844 1311413 R hypothetical protein complement(1310844..1311413) Mycobacterium bovis BCG str. Tokyo 172 7563393 YP_002644269.1 CDS fdxC NC_012207.1 1311626 1311952 D ferredoxin 1311626..1311952 Mycobacterium bovis BCG str. Tokyo 172 7562572 YP_002644270.1 CDS JTY_1214 NC_012207.1 1311985 1313073 D catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; N-succinyldiaminopimelate aminotransferase 1311985..1313073 Mycobacterium bovis BCG str. Tokyo 172 7563408 YP_002644271.1 CDS JTY_1215 NC_012207.1 1313101 1315920 R hypothetical protein complement(1313101..1315920) Mycobacterium bovis BCG str. Tokyo 172 7562573 YP_002644272.1 CDS pks3 NC_012207.1 1316347 1322604 D In Mycobacterium tuberculosis strain H37Rv, Rv1180 and Rv1181 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transversion (A-C) leads to a single product (similar to other organisms). Differs from Rv1181 by 2aa, A1068D, P1423A in BCG Pasteur and BCG Tokyo; polyketide beta-ketoacyl synthase 1316347..1322604 Mycobacterium bovis BCG str. Tokyo 172 7562574 YP_002644273.1 CDS papA3 NC_012207.1 1322657 1324075 D polyketide synthase associated protein 1322657..1324075 Mycobacterium bovis BCG str. Tokyo 172 7562120 YP_002644274.1 CDS mmpL10 NC_012207.1 1324142 1327150 D transmembrane transport protein 1324142..1327150 Mycobacterium bovis BCG str. Tokyo 172 7562513 YP_002644275.1 CDS JTY_1219 NC_012207.1 1327154 1328233 R hypothetical protein complement(1327154..1328233) Mycobacterium bovis BCG str. Tokyo 172 7564480 YP_002644276.1 CDS fadD21 NC_012207.1 1328398 1330134 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(1328398..1330134) Mycobacterium bovis BCG str. Tokyo 172 7562575 YP_002644277.1 CDS JTY_1221 NC_012207.1 1330311 1331927 R Differs from Rv1186c by 1aa, A207P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1330311..1331927) Mycobacterium bovis BCG str. Tokyo 172 7562927 YP_002644278.1 CDS rocA NC_012207.1 1332012 1333643 D pyrroline-5-carboxylate dehydrogenase 1332012..1333643 Mycobacterium bovis BCG str. Tokyo 172 7562576 YP_002644279.1 CDS JTY_1223 NC_012207.1 1333643 1334632 D proline dehydrogenase 1333643..1334632 Mycobacterium bovis BCG str. Tokyo 172 7561590 YP_002644280.1 CDS sigI NC_012207.1 1334714 1335586 D member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigI 1334714..1335586 Mycobacterium bovis BCG str. Tokyo 172 7562577 YP_002644281.1 CDS JTY_1225 NC_012207.1 1335602 1336480 D hypothetical protein 1335602..1336480 Mycobacterium bovis BCG str. Tokyo 172 7561793 YP_002644282.1 CDS JTY_1226 NC_012207.1 1336553 1337467 D hypothetical protein 1336553..1337467 Mycobacterium bovis BCG str. Tokyo 172 7562578 YP_002644283.1 CDS JTY_1227 NC_012207.1 1337549 1338376 D hypothetical protein 1337549..1338376 Mycobacterium bovis BCG str. Tokyo 172 7562579 YP_002644284.1 CDS JTY_1228 NC_012207.1 1338416 1339837 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1338416..1339837 Mycobacterium bovis BCG str. Tokyo 172 7562580 YP_002644285.1 CDS JTY_1229 NC_012207.1 1339870 1341135 R hypothetical protein complement(1339870..1341135) Mycobacterium bovis BCG str. Tokyo 172 7562581 YP_002644286.1 CDS PE13 NC_012207.1 1341611 1341910 D PE family protein 1341611..1341910 Mycobacterium bovis BCG str. Tokyo 172 7562582 YP_002644287.1 CDS PPE18 NC_012207.1 1341957 1343129 D In Mycobacterium bovis, a 14 bp to 11 bp substitution leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (390 aa versus 391 aa). Differs extensively from orthologs Mb1228 and Rv1196 due to numerous substitutions and transitions. Region from aa 210 - 260 shows most difference; PPE family protein 1341957..1343129 Mycobacterium bovis BCG str. Tokyo 172 7561713 YP_002644288.1 CDS esxK NC_012207.1 1343264 1343560 D Differs from Mb1229 by 1aa, A58T in BCG Pasteur and BCG Tokyo; EsaT-6 like protein 3 1343264..1343560 Mycobacterium bovis BCG str. Tokyo 172 7562154 YP_002644289.1 CDS esxL NC_012207.1 1343611 1343895 D Differs from Rv1198 by 1aa, D12A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; EsaT-6 like protein 4 1343611..1343895 Mycobacterium bovis BCG str. Tokyo 172 7562882 YP_002644290.1 CDS JTY_1234 NC_012207.1 1343963 1345210 R Differs from Rv1199c and Mb1231c by 1aa, G90D in Mycobacterium bovis BCG Pasteur and BCG Tokyo; transposase complement(1343963..1345210) Mycobacterium bovis BCG str. Tokyo 172 7562883 YP_002644291.1 CDS JTY_1235 NC_012207.1 1345547 1346824 D integral membrane transport protein 1345547..1346824 Mycobacterium bovis BCG str. Tokyo 172 7562583 YP_002644292.1 CDS JTY_1236 NC_012207.1 1346821 1347774 R transferase complement(1346821..1347774) Mycobacterium bovis BCG str. Tokyo 172 7562584 YP_002644293.1 CDS dapE NC_012207.1 1347865 1348929 D catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; succinyl-diaminopimelate desuccinylase 1347865..1348929 Mycobacterium bovis BCG str. Tokyo 172 7562585 YP_002644294.1 CDS JTY_1238 NC_012207.1 1348926 1349510 R hypothetical protein complement(1348926..1349510) Mycobacterium bovis BCG str. Tokyo 172 7561468 YP_002644295.1 CDS JTY_1239 NC_012207.1 1349541 1351229 R hypothetical protein complement(1349541..1351229) Mycobacterium bovis BCG str. Tokyo 172 7562586 YP_002644296.1 CDS JTY_1240 NC_012207.1 1351324 1351887 D hypothetical protein 1351324..1351887 Mycobacterium bovis BCG str. Tokyo 172 7562587 YP_002644297.1 CDS fadD6 NC_012207.1 1351937 1353730 D activates fatty acids by binding to coenzyme A; may be involved in acyclic terpene utilization; long-chain-acyl-CoA synthetase 1351937..1353730 Mycobacterium bovis BCG str. Tokyo 172 7562588 YP_002644298.1 CDS folP2 NC_012207.1 1353796 1354752 D dihydropteroate synthase 2 1353796..1354752 Mycobacterium bovis BCG str. Tokyo 172 7563354 YP_002644299.1 CDS JTY_1243 NC_012207.1 1354749 1355723 D glucosyl-3-phosphoglycerate synthase 1354749..1355723 Mycobacterium bovis BCG str. Tokyo 172 7563425 YP_002644300.1 CDS JTY_1244 NC_012207.1 1355762 1356130 D hypothetical protein 1355762..1356130 Mycobacterium bovis BCG str. Tokyo 172 7562589 YP_002644301.1 CDS tagA NC_012207.1 1356127 1356741 D DNA-3-methyladenine glycosylase I 1356127..1356741 Mycobacterium bovis BCG str. Tokyo 172 7562590 YP_002644302.1 CDS JTY_1246 NC_012207.1 1356848 1357075 D hypothetical protein 1356848..1357075 Mycobacterium bovis BCG str. Tokyo 172 7561820 YP_002644303.1 CDS JTY_1247 NC_012207.1 1357103 1358266 R Differs from Rv1212c by 2aa, I105V, W340L and from Mb1244c by 1aa, W340L in BCG Pasteur and BCG Tokyo; glycosyl transferase complement(1357103..1358266) Mycobacterium bovis BCG str. Tokyo 172 7562591 YP_002644304.1 CDS glgC NC_012207.1 1358441 1359655 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1358441..1359655 Mycobacterium bovis BCG str. Tokyo 172 7562592 YP_002644305.1 CDS PE14 NC_012207.1 1359898 1360230 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, PE14 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 5 bp deletion (cttgt-*) leads to a diffferent COOH terminus; PE family protein complement(1359898..1360230) Mycobacterium bovis BCG str. Tokyo 172 7561921 YP_002644306.1 CDS JTY_1250 NC_012207.1 1360364 1362049 R Differs from Rv1215c by 1aa, S169A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1360364..1362049) Mycobacterium bovis BCG str. Tokyo 172 7561714 YP_002644307.1 CDS JTY_1251 NC_012207.1 1362077 1362751 R integral membrane protein complement(1362077..1362751) Mycobacterium bovis BCG str. Tokyo 172 7562593 YP_002644308.1 CDS JTY_1252 NC_012207.1 1362760 1364406 R Differs from Mb1249c by 1aa, A143T in BCG Pasteur and BCG Tokyo; tetronasin-transport integral membrane protein ABC transporter complement(1362760..1364406) Mycobacterium bovis BCG str. Tokyo 172 7562594 YP_002644309.1 CDS JTY_1253 NC_012207.1 1364403 1365338 R Differs from Rv1218c by 1aa, R243Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; tetronasin-transport ATP-binding protein ABC transporter complement(1364403..1365338) Mycobacterium bovis BCG str. Tokyo 172 7562595 YP_002644310.1 CDS JTY_1254 NC_012207.1 1365328 1365966 R Differs from Rv1219c and Mb1251c by 1aa, C113W in BCG Pasteur and BCG Tokyo; transcriptional regulatory protein complement(1365328..1365966) Mycobacterium bovis BCG str. Tokyo 172 7562596 YP_002644311.1 CDS JTY_1255 NC_012207.1 1366108 1366755 R methyltransferase complement(1366108..1366755) Mycobacterium bovis BCG str. Tokyo 172 7562597 YP_002644312.1 CDS sigE NC_012207.1 1367018 1367791 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence; RNA polymerase sigma factor SigE 1367018..1367791 Mycobacterium bovis BCG str. Tokyo 172 7562598 YP_002644313.1 CDS JTY_1257 NC_012207.1 1367949 1368413 D hypothetical protein 1367949..1368413 Mycobacterium bovis BCG str. Tokyo 172 7560793 YP_002644314.1 CDS htrA NC_012207.1 1368482 1370068 D Differs from Rv1223 by 2aa, L288F, N445S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; serine protease 1368482..1370068 Mycobacterium bovis BCG str. Tokyo 172 7562599 YP_002644315.1 CDS tatB NC_012207.1 1370070 1370465 D mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 1370070..1370465 Mycobacterium bovis BCG str. Tokyo 172 7563333 YP_002644316.1 CDS JTY_1260 NC_012207.1 1370498 1371328 R hypothetical protein complement(1370498..1371328) Mycobacterium bovis BCG str. Tokyo 172 7561824 YP_002644317.1 CDS JTY_1261 NC_012207.1 1371439 1372902 R Differs from Rv1226c by 1aa, A450V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein complement(1371439..1372902) Mycobacterium bovis BCG str. Tokyo 172 7562600 YP_002644318.1 CDS JTY_1262 NC_012207.1 1372899 1373432 R transmembrane protein complement(1372899..1373432) Mycobacterium bovis BCG str. Tokyo 172 7562601 YP_002644319.1 CDS lpqX NC_012207.1 1373527 1374084 D lipoprotein 1373527..1374084 Mycobacterium bovis BCG str. Tokyo 172 7562602 YP_002644320.1 CDS mrp NC_012207.1 1374384 1375556 R MRP-related protein complement(1374384..1375556) Mycobacterium bovis BCG str. Tokyo 172 7560516 YP_002644321.1 CDS JTY_1265 NC_012207.1 1375569 1376804 R Differs from Rv1230c by 2aa, G45S, P97S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1375569..1376804) Mycobacterium bovis BCG str. Tokyo 172 7563560 YP_002644322.1 CDS JTY_1266 NC_012207.1 1376929 1377471 R hypothetical protein complement(1376929..1377471) Mycobacterium bovis BCG str. Tokyo 172 7562603 YP_002644323.1 CDS JTY_1267 NC_012207.1 1377468 1378775 R Differs from Rv1232c by 1aa, G149C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1377468..1378775) Mycobacterium bovis BCG str. Tokyo 172 7562604 YP_002644324.1 CDS JTY_1268 NC_012207.1 1378837 1379433 R Differs from Rv1233c by 1aa, D46N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1378837..1379433) Mycobacterium bovis BCG str. Tokyo 172 7562605 YP_002644325.1 CDS JTY_1269 NC_012207.1 1379583 1380110 D transmembrane protein 1379583..1380110 Mycobacterium bovis BCG str. Tokyo 172 7562606 YP_002644326.1 CDS lpqY NC_012207.1 1380131 1381537 D sugar-binding lipoprotein 1380131..1381537 Mycobacterium bovis BCG str. Tokyo 172 7562607 YP_002644327.1 CDS sugA NC_012207.1 1381534 1382457 D sugar-transport integral membrane protein ABC transporter 1381534..1382457 Mycobacterium bovis BCG str. Tokyo 172 7560517 YP_002644328.1 CDS sugB NC_012207.1 1382462 1383286 D sugar-transport integral membrane protein ABC transporter 1382462..1383286 Mycobacterium bovis BCG str. Tokyo 172 7561815 YP_002644329.1 CDS sugC NC_012207.1 1383291 1384472 D sugar-transport ATP-binding protein ABC transporter 1383291..1384472 Mycobacterium bovis BCG str. Tokyo 172 7561816 YP_002644330.1 CDS corA NC_012207.1 1384549 1385649 R Differs from Rv1239c by 1aa, E139K, and from Mb1271c by 1aa, H195R in BCG Pasteur and BCG Tokyo; magnesium and cobalt transport transmembrane protein complement(1384549..1385649) Mycobacterium bovis BCG str. Tokyo 172 7561817 YP_002644331.1 CDS mdh NC_012207.1 1385820 1386809 D catalyzes the oxidation of malate to oxaloacetate; malate dehydrogenase 1385820..1386809 Mycobacterium bovis BCG str. Tokyo 172 7563120 YP_002644332.1 CDS JTY_1276 NC_012207.1 1386885 1387145 D hypothetical protein 1386885..1387145 Mycobacterium bovis BCG str. Tokyo 172 7564448 YP_002644333.1 CDS JTY_1277 NC_012207.1 1387142 1387573 D hypothetical protein 1387142..1387573 Mycobacterium bovis BCG str. Tokyo 172 7562608 YP_002644334.1 CDS PE_PGRS23 NC_012207.1 1387596 1389284 R PE-PGRS family protein complement(1387596..1389284) Mycobacterium bovis BCG str. Tokyo 172 7562609 YP_002644335.1 CDS lpqZ NC_012207.1 1389464 1390324 D Differs from Rv1244 by 1aa, K242Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 1389464..1390324 Mycobacterium bovis BCG str. Tokyo 172 7561764 YP_002644336.1 CDS JTY_1280 NC_012207.1 1390405 1391235 R short-chain type dehydrogenase/reductase complement(1390405..1391235) Mycobacterium bovis BCG str. Tokyo 172 7560518 YP_002644337.1 CDS JTY_1281 NC_012207.1 1391292 1391585 R hypothetical protein complement(1391292..1391585) Mycobacterium bovis BCG str. Tokyo 172 7563594 YP_002644338.1 CDS JTY_1282 NC_012207.1 1391582 1391851 R hypothetical protein complement(1391582..1391851) Mycobacterium bovis BCG str. Tokyo 172 7563595 YP_002644339.1 CDS kgd NC_012207.1 1391964 1395608 R kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; alpha-ketoglutarate decarboxylase complement(1391964..1395608) Mycobacterium bovis BCG str. Tokyo 172 7563596 YP_002644340.1 CDS JTY_1284 NC_012207.1 1395801 1396589 R Differs from Rv1249c by 1aa, T95A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1395801..1396589) Mycobacterium bovis BCG str. Tokyo 172 7562807 YP_002644341.1 CDS JTY_1285 NC_012207.1 1396786 1398525 D Differs from Rv1250 by 1aa, G278R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; drug-transport integral membrane protein 1396786..1398525 Mycobacterium bovis BCG str. Tokyo 172 7563597 YP_002644342.1 CDS JTY_1286 NC_012207.1 1398428 1401847 R hypothetical protein complement(1398428..1401847) Mycobacterium bovis BCG str. Tokyo 172 7563598 YP_002644343.1 CDS lprE NC_012207.1 1401903 1402511 R lipoprotein complement(1401903..1402511) Mycobacterium bovis BCG str. Tokyo 172 7563599 YP_002644344.1 CDS deaD NC_012207.1 1402577 1404268 D Differs from Rv1253 by 1aa, V143M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cold-shock dead-box protein a homolog 1402577..1404268 Mycobacterium bovis BCG str. Tokyo 172 7560523 YP_002644345.1 CDS JTY_1289 NC_012207.1 1404265 1405416 D acyltransferase 1404265..1405416 Mycobacterium bovis BCG str. Tokyo 172 7561473 YP_002644346.1 CDS JTY_1290 NC_012207.1 1405385 1405684 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 3007 bp deletion (RD13) leads to the fusion of Rv1257c and Rv1255c, and the deletion of Rv1256c, compared to Mycobacterium tuberculosis strain H37Rv; hypothetical protein complement(1405385..1405684) Mycobacterium bovis BCG str. Tokyo 172 7563600 YP_002644347.1 CDS JTY_1291 NC_012207.1 1405681 1406940 R integral membrane transport protein complement(1405681..1406940) Mycobacterium bovis BCG str. Tokyo 172 7563601 YP_002644348.1 CDS JTY_1292 NC_012207.1 1406939 1407838 D hypothetical protein 1406939..1407838 Mycobacterium bovis BCG str. Tokyo 172 7563602 YP_002644349.1 CDS JTY_1293 NC_012207.1 1407840 1408664 D In Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv1260 into 2 parts; oxidoreductase 1407840..1408664 Mycobacterium bovis BCG str. Tokyo 172 7563603 YP_002644350.1 CDS JTY_1294 NC_012207.1 1408649 1408957 D In Mycobacterium tuberculosis strain H37Rv, Rv1260 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits Rv1260 into 2 parts; oxidoreductase 1408649..1408957 Mycobacterium bovis BCG str. Tokyo 172 7563604 YP_002644351.1 CDS JTY_1295 NC_012207.1 1409083 1409532 R hypothetical protein complement(1409083..1409532) Mycobacterium bovis BCG str. Tokyo 172 7563605 YP_002644352.1 CDS JTY_1296 NC_012207.1 1409537 1409971 R Differs from Rv1262c by 1aa, R104P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical HIT-like protein complement(1409537..1409971) Mycobacterium bovis BCG str. Tokyo 172 7563606 YP_002644353.1 CDS amiB2 NC_012207.1 1410030 1411418 D catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 1410030..1411418 Mycobacterium bovis BCG str. Tokyo 172 7563607 YP_002644354.1 CDS JTY_1298 NC_012207.1 1411493 1412686 D Differs from Rv1264 by 1aa, C204R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; adenylyl cyclase 1411493..1412686 Mycobacterium bovis BCG str. Tokyo 172 7563972 YP_002644355.1 CDS JTY_1299 NC_012207.1 1412859 1413539 D hypothetical protein 1412859..1413539 Mycobacterium bovis BCG str. Tokyo 172 7563608 YP_002644356.1 CDS pknH NC_012207.1 1413559 1415349 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, the pknH gene contains several substitutions, transitions and transversions compared to Mycobacterium tuberculosis strain H37Rv. The most significant difference results from a 127 bp to 24 bp substitution that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (596 aa versus 626 aa). Differs from Mb1297c by 2aa, F374L, I396N in BCG Pasteur and BCG Tokyo; transmembrane serine/threonine-protein kinase H complement(1413559..1415349) Mycobacterium bovis BCG str. Tokyo 172 7563609 YP_002644357.1 CDS embR NC_012207.1 1415690 1416856 R transcriptional regulatory protein complement(1415690..1416856) Mycobacterium bovis BCG str. Tokyo 172 7562435 YP_002644358.1 CDS JTY_1302 NC_012207.1 1417167 1417865 R hypothetical protein complement(1417167..1417865) Mycobacterium bovis BCG str. Tokyo 172 7562860 YP_002644359.1 CDS JTY_1303 NC_012207.1 1418088 1418462 R hypothetical protein complement(1418088..1418462) Mycobacterium bovis BCG str. Tokyo 172 7563610 YP_002644360.1 CDS lprA NC_012207.1 1418523 1419257 R Differs from Mb1301c by 1aa, A134T in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein complement(1418523..1419257) Mycobacterium bovis BCG str. Tokyo 172 7563611 YP_002644361.1 CDS JTY_1305 NC_012207.1 1419470 1419811 R hypothetical protein complement(1419470..1419811) Mycobacterium bovis BCG str. Tokyo 172 7560519 YP_002644362.1 CDS JTY_1306 NC_012207.1 1419919 1421814 R drugs-transport transmembrane ATP-binding protein ABC transporter complement(1419919..1421814) Mycobacterium bovis BCG str. Tokyo 172 7563612 YP_002644363.1 CDS JTY_1307 NC_012207.1 1421811 1423559 R drugs-transport transmembrane ATP-binding protein ABC transporter complement(1421811..1423559) Mycobacterium bovis BCG str. Tokyo 172 7563613 YP_002644364.1 CDS lprB NC_012207.1 1423706 1424263 D Differs from Rv1274 by 1aa, P168L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 1423706..1424263 Mycobacterium bovis BCG str. Tokyo 172 7563614 YP_002644365.1 CDS lprC NC_012207.1 1424260 1424802 D lipoprotein 1424260..1424802 Mycobacterium bovis BCG str. Tokyo 172 7560520 YP_002644366.1 CDS JTY_1310 NC_012207.1 1424947 1425423 R Differs from Rv1276c by 1aa, S92T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1424947..1425423) Mycobacterium bovis BCG str. Tokyo 172 7560521 YP_002644367.1 CDS JTY_1311 NC_012207.1 1425673 1426926 D hypothetical protein 1425673..1426926 Mycobacterium bovis BCG str. Tokyo 172 7563615 YP_002644368.1 CDS JTY_1312 NC_012207.1 1426923 1429550 D hypothetical protein 1426923..1429550 Mycobacterium bovis BCG str. Tokyo 172 7563616 YP_002644369.1 CDS JTY_1313 NC_012207.1 1429571 1431157 D dehydrogenase FAD flavoprotein gmc oxidoreductase 1429571..1431157 Mycobacterium bovis BCG str. Tokyo 172 7563617 YP_002644370.1 CDS oppA NC_012207.1 1431174 1432949 R periplasmic oligopeptide-binding lipoprotein complement(1431174..1432949) Mycobacterium bovis BCG str. Tokyo 172 7563618 YP_002644371.1 CDS oppD NC_012207.1 1432942 1434780 R oligopeptide-transport ATP-binding protein ABC transporter complement(1432942..1434780) Mycobacterium bovis BCG str. Tokyo 172 7562497 YP_002644372.1 CDS oppC NC_012207.1 1434777 1435652 R oligopeptide-transport integral membrane protein ABC transporter complement(1434777..1435652) Mycobacterium bovis BCG str. Tokyo 172 7562500 YP_002644373.1 CDS oppB NC_012207.1 1435649 1436626 R oligopeptide-transport integral membrane protein ABC transporter complement(1435649..1436626) Mycobacterium bovis BCG str. Tokyo 172 7562499 YP_002644374.1 CDS canA NC_012207.1 1436833 1437324 D beta-carbonic anhydrase 1436833..1437324 Mycobacterium bovis BCG str. Tokyo 172 7562498 YP_002644375.1 CDS cysD NC_012207.1 1437418 1438416 D with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 1437418..1438416 Mycobacterium bovis BCG str. Tokyo 172 7562080 YP_002644376.1 CDS cysN NC_012207.1 1438416 1440260 D in Rhizobium meliloti this protein is involved in the synthesis of nodulation factors that are active on the roots of alfalfa; catalyzes formation of activated sulfate intermediate; converts ATP and sulfate to diphosphate and adenylylsulfate and then ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; the activated intermediate is transferred to the nodulation factors by NodH; may interact with NodP and NodQ; similar to the CysD and CysN proteins from EScherichia coli involved in cysteine biosynthesis; bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein 1438416..1440260 Mycobacterium bovis BCG str. Tokyo 172 7563175 YP_002644377.1 CDS JTY_1321 NC_012207.1 1440314 1440799 D hypothetical protein 1440314..1440799 Mycobacterium bovis BCG str. Tokyo 172 7563181 YP_002644378.1 CDS JTY_1322 NC_012207.1 1440857 1442074 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 153 bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (405 aa versus 456 aa); hypothetical protein 1440857..1442074 Mycobacterium bovis BCG str. Tokyo 172 7563619 YP_002644379.1 CDS JTY_1323 NC_012207.1 1442123 1442755 D hypothetical protein 1442123..1442755 Mycobacterium bovis BCG str. Tokyo 172 7563620 YP_002644380.1 CDS JTY_1324 NC_012207.1 1442894 1444459 R hypothetical protein complement(1442894..1444459) Mycobacterium bovis BCG str. Tokyo 172 7563621 YP_002644381.1 CDS JTY_1325 NC_012207.1 1444470 1444784 D hypothetical protein 1444470..1444784 Mycobacterium bovis BCG str. Tokyo 172 7563622 YP_002644382.1 CDS JTY_1326 NC_012207.1 1444911 1445246 R hypothetical protein complement(1444911..1445246) Mycobacterium bovis BCG str. Tokyo 172 7563623 YP_002644383.1 CDS argS NC_012207.1 1445791 1447443 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1445791..1447443 Mycobacterium bovis BCG str. Tokyo 172 7563994 YP_002644384.1 CDS lysA NC_012207.1 1447440 1448783 D diaminopimelate decarboxylase 1447440..1448783 Mycobacterium bovis BCG str. Tokyo 172 7563991 YP_002644385.1 CDS thrA NC_012207.1 1448787 1450112 D catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1448787..1450112 Mycobacterium bovis BCG str. Tokyo 172 7560540 YP_002644386.1 CDS thrC NC_012207.1 1450109 1451191 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1450109..1451191 Mycobacterium bovis BCG str. Tokyo 172 7561850 YP_002644387.1 CDS thrB NC_012207.1 1451409 1452359 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1451409..1452359 Mycobacterium bovis BCG str. Tokyo 172 7561852 YP_002644388.1 CDS rho NC_012207.1 1452616 1454424 D An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 1452616..1454424 Mycobacterium bovis BCG str. Tokyo 172 7561851 YP_002644389.1 CDS rpmE NC_012207.1 1454575 1454817 D RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1454575..1454817 Mycobacterium bovis BCG str. Tokyo 172 7561570 YP_002644390.1 CDS prfA NC_012207.1 1454907 1455980 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1454907..1455980 Mycobacterium bovis BCG str. Tokyo 172 7560718 YP_002644391.1 CDS hemK NC_012207.1 1455977 1456954 D Differs from Mb1332 by 1aa, G121A, and from Rv1300by 2aa, G121A, C194R in Mycobacterium bovis BCG Pasteur and BCG Tokyo; HemK protein homolog 1455977..1456954 Mycobacterium bovis BCG str. Tokyo 172 7560821 YP_002644392.1 CDS JTY_1336 NC_012207.1 1456970 1457623 D Differs from Rv1301 by 1aa, Q196P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein 1456970..1457623 Mycobacterium bovis BCG str. Tokyo 172 7563302 YP_002644393.1 CDS rfe NC_012207.1 1457707 1458921 D Differs from Rv1302 by 1aa, G357V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase 1457707..1458921 Mycobacterium bovis BCG str. Tokyo 172 7563625 YP_002644394.1 CDS JTY_1338 NC_012207.1 1459178 1459663 D hypothetical protein 1459178..1459663 Mycobacterium bovis BCG str. Tokyo 172 7561568 YP_002644395.1 CDS atpB NC_012207.1 1459656 1460408 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 1459656..1460408 Mycobacterium bovis BCG str. Tokyo 172 7563626 YP_002644396.1 CDS atpE NC_012207.1 1460457 1460702 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 1460457..1460702 Mycobacterium bovis BCG str. Tokyo 172 7562048 YP_002644397.1 CDS atpF NC_012207.1 1460733 1461248 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 1460733..1461248 Mycobacterium bovis BCG str. Tokyo 172 7562051 YP_002644398.1 CDS atpH NC_012207.1 1461255 1462595 D produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 1461255..1462595 Mycobacterium bovis BCG str. Tokyo 172 7562052 YP_002644399.1 CDS atpA NC_012207.1 1462640 1464289 D produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 1462640..1464289 Mycobacterium bovis BCG str. Tokyo 172 7562054 YP_002644400.1 CDS atpG NC_012207.1 1464296 1465213 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 1464296..1465213 Mycobacterium bovis BCG str. Tokyo 172 7562047 YP_002644401.1 CDS atpD NC_012207.1 1465253 1466713 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 1465253..1466713 Mycobacterium bovis BCG str. Tokyo 172 7562053 YP_002644402.1 CDS atpC NC_012207.1 1466727 1467092 D part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 1466727..1467092 Mycobacterium bovis BCG str. Tokyo 172 7562050 YP_002644403.1 CDS JTY_1347 NC_012207.1 1467100 1467534 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 2 bp deletion (CG-*) at the 3' end leads to a slightly shorter product compared to Mycobacterium tuberculosis strain H37Rv (144 aa versus 147 aa). Also differs from Rv1312 by 1aa, V3A in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 1467100..1467534 Mycobacterium bovis BCG str. Tokyo 172 7562049 YP_002644404.1 CDS JTY_1348 NC_012207.1 1467581 1468915 R Equivalent to Rv1313c (IS1557) in BCG Tokyo. Equivalent to Mb1345c and Mb1346c in BCG Pasteur (BCG_1373c and BCG_1374c). In Mycobacterium tuberculosis strain H37Rv, Rv1313c exists as a single gene. In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur, a frameshift due to a 12 bp to 1bp substitution (CTTGTCGTGGCC-T) splits Rv1313c into 2 parts; transposase complement(1467581..1468915) Mycobacterium bovis BCG str. Tokyo 172 7563627 YP_002644405.1 CDS JTY_1349 NC_012207.1 1469081 1469662 R hypothetical protein complement(1469081..1469662) Mycobacterium bovis BCG str. Tokyo 172 7563628 YP_002644406.1 CDS murA NC_012207.1 1469731 1470987 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1469731..1470987 Mycobacterium bovis BCG str. Tokyo 172 7563629 YP_002644407.1 CDS ogt NC_012207.1 1476544 1477041 R methylated-DNA--protein-cysteine methyltransferase complement(1476544..1477041) Mycobacterium bovis BCG str. Tokyo 172 7564326 YP_002644408.1 CDS alkA NC_012207.1 1477038 1478528 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, alkA exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) introduces a premature stop codon that splits alkA into 2 parts, alkAa and alkAb; ada regulatory protein complement(1477038..1478528) Mycobacterium bovis BCG str. Tokyo 172 7562492 YP_002644409.1 CDS JTY_1353 NC_012207.1 1478609 1480234 R adenylate cyclase complement(1478609..1480234) Mycobacterium bovis BCG str. Tokyo 172 7563962 YP_002644410.1 CDS JTY_1354 NC_012207.1 1480304 1481911 R adenylate cyclase complement(1480304..1481911) Mycobacterium bovis BCG str. Tokyo 172 7563630 YP_002644411.1 CDS JTY_1355 NC_012207.1 1481924 1483627 R Differs from Rv1320c by 1aa, A531T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; adenylate cyclase complement(1481924..1483627) Mycobacterium bovis BCG str. Tokyo 172 7563631 YP_002644412.1 CDS JTY_1356 NC_012207.1 1483689 1484369 D Differs from Rv1321 by 1aa, R144S in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1483689..1484369 Mycobacterium bovis BCG str. Tokyo 172 7563632 YP_002644413.1 CDS JTY_1357 NC_012207.1 1484392 1484688 D hypothetical protein 1484392..1484688 Mycobacterium bovis BCG str. Tokyo 172 7563633 YP_002644414.1 CDS JTY_1358 NC_012207.1 1484723 1485181 R hypothetical protein complement(1484723..1485181) Mycobacterium bovis BCG str. Tokyo 172 7563634 YP_002644415.1 CDS fadA4 NC_012207.1 1485272 1486441 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 1485272..1486441 Mycobacterium bovis BCG str. Tokyo 172 7563635 YP_002644416.1 CDS JTY_1360 NC_012207.1 1486571 1487485 D thioredoxin 1486571..1487485 Mycobacterium bovis BCG str. Tokyo 172 7562907 YP_002644417.1 CDS PE_PGRS24 NC_012207.1 1487564 1489366 R Differs from Rv1325c by 3aa:AGG, there are deleted in Mycobacterium bovis BCG Tokyo.; PE-PGRS family protein complement(1487564..1489366) Mycobacterium bovis BCG str. Tokyo 172 7563636 YP_002644418.1 CDS glgB NC_012207.1 1489518 1491713 R catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme complement(1489518..1491713) Mycobacterium bovis BCG str. Tokyo 172 7561765 YP_002644419.1 CDS glgE NC_012207.1 1491721 1493826 R glucanase complement(1491721..1493826) Mycobacterium bovis BCG str. Tokyo 172 7561920 YP_002644420.1 CDS glgP NC_012207.1 1493965 1496556 D Differs from Rv1328 by 3aa, G532D, F576V, S801A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; glycogen phosphorylase 1493965..1496556 Mycobacterium bovis BCG str. Tokyo 172 7561922 YP_002644421.1 CDS dinG NC_012207.1 1496596 1498590 R ATP-dependent helicase DinG homolog complement(1496596..1498590) Mycobacterium bovis BCG str. Tokyo 172 7561923 YP_002644422.1 CDS JTY_1366 NC_012207.1 1498614 1499960 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1498614..1499960) Mycobacterium bovis BCG str. Tokyo 172 7561494 YP_002644423.1 CDS clpS NC_012207.1 1500062 1500367 D involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 1500062..1500367 Mycobacterium bovis BCG str. Tokyo 172 7563637 YP_002644424.1 CDS JTY_1368 NC_012207.1 1500327 1500983 D transcriptional regulatory protein 1500327..1500983 Mycobacterium bovis BCG str. Tokyo 172 7562111 YP_002644425.1 CDS JTY_1369 NC_012207.1 1501000 1502034 D hydrolase 1501000..1502034 Mycobacterium bovis BCG str. Tokyo 172 7563638 YP_002644426.1 CDS JTY_1370 NC_012207.1 1502042 1502482 D hypothetical protein 1502042..1502482 Mycobacterium bovis BCG str. Tokyo 172 7563639 YP_002644427.1 CDS JTY_1371 NC_012207.1 1502504 1502785 D hypothetical protein 1502504..1502785 Mycobacterium bovis BCG str. Tokyo 172 7563640 YP_002644428.1 CDS cysM NC_012207.1 1502795 1503766 D cysteine synthase B 1502795..1503766 Mycobacterium bovis BCG str. Tokyo 172 7563641 YP_002644429.1 CDS JTY_1373 NC_012207.1 1503757 1504479 D integral membrane protein 1503757..1504479 Mycobacterium bovis BCG str. Tokyo 172 7563180 YP_002644430.1 CDS murI NC_012207.1 1504476 1505291 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1504476..1505291 Mycobacterium bovis BCG str. Tokyo 172 7563642 YP_002644431.1 CDS JTY_1375 NC_012207.1 1505318 1506139 D hypothetical protein 1505318..1506139 Mycobacterium bovis BCG str. Tokyo 172 7563578 YP_002644432.1 CDS rph NC_012207.1 1506156 1506935 D RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 1506156..1506935 Mycobacterium bovis BCG str. Tokyo 172 7563643 YP_002644433.1 CDS JTY_1377 NC_012207.1 1506974 1507588 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 1506974..1507588 Mycobacterium bovis BCG str. Tokyo 172 7561601 YP_002644434.1 CDS JTY_1378 NC_012207.1 1507585 1507947 R hypothetical protein complement(1507585..1507947) Mycobacterium bovis BCG str. Tokyo 172 7563644 YP_002644435.1 CDS lprD NC_012207.1 1507944 1508324 R Differs from Rv1343c by 1aa, A81E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein complement(1507944..1508324) Mycobacterium bovis BCG str. Tokyo 172 7563645 YP_002644436.1 CDS JTY_1380 NC_012207.1 1508369 1508689 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1508369..1508689 Mycobacterium bovis BCG str. Tokyo 172 7560522 YP_002644437.1 CDS fadD33 NC_012207.1 1508682 1510247 D converts medium- to long-chain aliphatic fatty acids into acyl adenylate; involved in mycobactin synthesis; long-chain fatty acid--ACP ligase 1508682..1510247 Mycobacterium bovis BCG str. Tokyo 172 7563646 YP_002644438.1 CDS fadE14 NC_012207.1 1510247 1511407 D acyl-CoA dehydrogenase 1510247..1511407 Mycobacterium bovis BCG str. Tokyo 172 7563349 YP_002644439.1 CDS JTY_1383 NC_012207.1 1511374 1512006 R hypothetical protein complement(1511374..1512006) Mycobacterium bovis BCG str. Tokyo 172 7563362 YP_002644440.1 CDS JTY_1384 NC_012207.1 1512448 1515027 D drugs-transport transmembrane ATP-binding protein ABC transporter 1512448..1515027 Mycobacterium bovis BCG str. Tokyo 172 7562821 YP_002644441.1 CDS JTY_1385 NC_012207.1 1515024 1516763 D drugs-transport transmembrane ATP-binding protein ABC transporter 1515024..1516763 Mycobacterium bovis BCG str. Tokyo 172 7563648 YP_002644442.1 CDS fabG NC_012207.1 1516892 1517635 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1516892..1517635 Mycobacterium bovis BCG str. Tokyo 172 7563649 YP_002644443.1 CDS JTY_1387 NC_012207.1 1517632 1517961 D hypothetical protein 1517632..1517961 Mycobacterium bovis BCG str. Tokyo 172 7562897 YP_002644444.1 CDS JTY_1388 NC_012207.1 1518164 1518535 D hypothetical protein 1518164..1518535 Mycobacterium bovis BCG str. Tokyo 172 7563650 YP_002644445.1 CDS JTY_1389 NC_012207.1 1518601 1519386 R transcriptional regulatory protein complement(1518601..1519386) Mycobacterium bovis BCG str. Tokyo 172 7563651 YP_002644446.1 CDS JTY_1390 NC_012207.1 1519406 1521277 R hypothetical protein complement(1519406..1521277) Mycobacterium bovis BCG str. Tokyo 172 7563652 YP_002644447.1 CDS moeY NC_012207.1 1521286 1523433 R Differs from Rv1355c by 1aa (P81L) in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1521286..1523433) Mycobacterium bovis BCG str. Tokyo 172 7563653 YP_002644448.1 CDS JTY_1392 NC_012207.1 1523430 1524221 R hypothetical protein complement(1523430..1524221) Mycobacterium bovis BCG str. Tokyo 172 7563545 YP_002644449.1 CDS JTY_1393 NC_012207.1 1524694 1525617 R Differs from Rv1357c and Mb1392c by 1aa, S276T in BCG Pasteur and BCG Tokyo; hypothetical protein complement(1524694..1525617) Mycobacterium bovis BCG str. Tokyo 172 7563654 YP_002644450.1 CDS JTY_1394 NC_012207.1 1526013 1529492 D Differs from Rv1358 by 1aa A442D, and from Mb1393 by 1aa, G31V in BCG Pasteur and BCG Tokyo; transcriptional regulatory protein 1526013..1529492 Mycobacterium bovis BCG str. Tokyo 172 7563655 YP_002644451.1 CDS JTY_1395 NC_012207.1 1529574 1530326 D Differs from Mb1394 by 1aa, G187R in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional regulatory protein 1529574..1530326 Mycobacterium bovis BCG str. Tokyo 172 7563656 YP_002644452.1 CDS JTY_1396 NC_012207.1 1530749 1531771 D oxidoreductase 1530749..1531771 Mycobacterium bovis BCG str. Tokyo 172 7563657 YP_002644453.1 CDS PPE19 NC_012207.1 1531844 1533034 R Differs from Rv1361c by 3aa, Q30K, V55T, P325Q in BCG Pasteur and BCG Tokyo, and more extensively from Mb1396c due to several substitutions, transitions and transversions between codons 158-260; PPE family protein complement(1531844..1533034) Mycobacterium bovis BCG str. Tokyo 172 7563658 YP_002644454.1 CDS JTY_1398 NC_012207.1 1533349 1534011 R Differs from Rv1362c by 1aa, G103V Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1533349..1534011) Mycobacterium bovis BCG str. Tokyo 172 7562155 YP_002644455.1 CDS JTY_1399 NC_012207.1 1534008 1534793 R Difefrs from Mb1398c by 1aa, T155N in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1534008..1534793) Mycobacterium bovis BCG str. Tokyo 172 7563659 YP_002644456.1 CDS JTY_1400 NC_012207.1 1535084 1537045 R Differs from Rv1364c by 2aa, T236A, E465A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1535084..1537045) Mycobacterium bovis BCG str. Tokyo 172 7563660 YP_002644457.1 CDS JTY_1401 NC_012207.1 1537184 1537570 R Differs from Rv1365c by 1aa, K82E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1537184..1537570) Mycobacterium bovis BCG str. Tokyo 172 7563661 YP_002644458.1 CDS JTY_1402 NC_012207.1 1537791 1538612 D hypothetical protein 1537791..1538612 Mycobacterium bovis BCG str. Tokyo 172 7563662 YP_002644459.1 CDS JTY_1403 NC_012207.1 1538913 1540046 R Differs from Rv1367c by 1aa, V169I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1538913..1540046) Mycobacterium bovis BCG str. Tokyo 172 7563663 YP_002644460.1 CDS lprF NC_012207.1 1540421 1541206 D lipoprotein 1540421..1541206 Mycobacterium bovis BCG str. Tokyo 172 7563664 YP_002644461.1 CDS JTY_1405 NC_012207.1 1541402 1542355 D In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-A) splits Rv1371 into 2 parts, with the latter being the more likely product; hypothetical protein 1541402..1542355 Mycobacterium bovis BCG str. Tokyo 172 7560524 YP_002644462.1 CDS JTY_1406 NC_012207.1 1541877 1542872 D In Mycobacterium tuberculosis strain H37Rv, Rv1371 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-A) splits Rv1371 into 2 parts, with the latter being the more likely product. Differs from both Mb1405 and Rv1371 by 1aa, V210I in Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 1541877..1542872 Mycobacterium bovis BCG str. Tokyo 172 7563665 YP_002644463.1 CDS JTY_1407 NC_012207.1 1542869 1544050 D Differs from Rv1372 and Mb1406 by 2aa, N75K, A101T in Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 1542869..1544050 Mycobacterium bovis BCG str. Tokyo 172 7563666 YP_002644464.1 CDS JTY_1408 NC_012207.1 1544056 1544604 D In Mycobacterium tuberculosis strain H37Rv, Rv1373 exists as a single gene as is the case in Mycobacterium bovis BCG Pasteur. In Mycobacterium bovis, a frameshift due to a single base insertion (*-C) splits Rv1373 into 2 parts, Mb1407 and Mb1408. Differs from Rv1373 by 2aa, additional P, P155, and L232P in BCG Pasteur. In Mycobacterium bovis BCG Tokyo, a frameshift due to two base insertions (*-cc) splits Rv1373 into 2 parts (182 aa, 155 aa). 9Cs in BCG Tokyo, 10Cs in BCG Pasteur.; glycolipid sulfotransferase 1544056..1544604 Mycobacterium bovis BCG str. Tokyo 172 7563667 YP_002644465.1 CDS JTY_1409 NC_012207.1 1544571 1545038 D In Mycobacterium tuberculosis strain H37Rv, Rv1373 exists as a single gene as is the case in Mycobacterium bovis BCG Pasteur. In Mycobacterium bovis, a frameshift due to a single base insertion (*-) splits Rv1373 into 2 parts, Mb1407 and Mb1408. Differs from Rv1373 by 2aa, additional P, P155, and L232P in BCG Pasteur. In Mycobacterium bovis BCG Tokyo, a frameshift due to two base insertions (*-CC) splits Rv1373 into 2 parts (182 aa, 155 aa).; glycolipid sulfotransferase 1544571..1545038 Mycobacterium bovis BCG str. Tokyo 172 7563668 YP_002644466.1 CDS JTY_1410 NC_012207.1 1545118 1545576 R Differs from Rv1374c by 1aa, A136T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1545118..1545576) Mycobacterium bovis BCG str. Tokyo 172 7563669 YP_002644467.1 CDS JTY_1411 NC_012207.1 1545878 1547197 D Differs from Rv1375 by 1aa, R86G, and from Mb1410by 1aa, R322P in Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 1545878..1547197 Mycobacterium bovis BCG str. Tokyo 172 7563670 YP_002644468.1 CDS JTY_1412 NC_012207.1 1547194 1548687 D Differs from Rv1376 by 1aa, P236R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1547194..1548687 Mycobacterium bovis BCG str. Tokyo 172 7563671 YP_002644469.1 CDS JTY_1413 NC_012207.1 1548625 1549263 R transferase complement(1548625..1549263) Mycobacterium bovis BCG str. Tokyo 172 7563672 YP_002644470.1 CDS JTY_1414 NC_012207.1 1549274 1550701 R Differs from Rv1378c by 1aa, W37R, and from Mb1413c by 1aa, R9H in BCG Pasteur and BCG Tokyo; hypothetical protein complement(1549274..1550701) Mycobacterium bovis BCG str. Tokyo 172 7563673 YP_002644471.1 CDS pyrR NC_012207.1 1550700 1551281 D regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase 1550700..1551281 Mycobacterium bovis BCG str. Tokyo 172 7563674 YP_002644472.1 CDS pyrB NC_012207.1 1551278 1552237 D catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 1551278..1552237 Mycobacterium bovis BCG str. Tokyo 172 7561544 YP_002644473.1 CDS pyrC NC_012207.1 1552234 1553526 D catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1552234..1553526 Mycobacterium bovis BCG str. Tokyo 172 7560870 YP_002644474.1 CDS JTY_1418 NC_012207.1 1553523 1554020 D export or membrane protein 1553523..1554020 Mycobacterium bovis BCG str. Tokyo 172 7560871 YP_002644475.1 CDS carA NC_012207.1 1554017 1555147 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1554017..1555147 Mycobacterium bovis BCG str. Tokyo 172 7563675 YP_002644476.1 CDS carB NC_012207.1 1555147 1558494 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1555147..1558494 Mycobacterium bovis BCG str. Tokyo 172 7562082 YP_002644477.1 CDS pyrF NC_012207.1 1558491 1559315 D type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1558491..1559315 Mycobacterium bovis BCG str. Tokyo 172 7562083 YP_002644478.1 CDS PE15 NC_012207.1 1559510 1559818 D PE family protein 1559510..1559818 Mycobacterium bovis BCG str. Tokyo 172 7560874 YP_002644479.1 CDS PPE20 NC_012207.1 1559815 1561434 D Differs from Rv1387 by 1aa, A94V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PPE family protein 1559815..1561434 Mycobacterium bovis BCG str. Tokyo 172 7561715 YP_002644480.1 CDS mihF NC_012207.1 1561740 1562312 D integration host factor 1561740..1562312 Mycobacterium bovis BCG str. Tokyo 172 7562157 YP_002644481.1 CDS gmk NC_012207.1 1562447 1563073 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1562447..1563073 Mycobacterium bovis BCG str. Tokyo 172 7564474 YP_002644482.1 CDS rpoZ NC_012207.1 1563139 1563471 D Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1563139..1563471 Mycobacterium bovis BCG str. Tokyo 172 7563271 YP_002644483.1 CDS dfp NC_012207.1 1563487 1564743 D catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 1563487..1564743 Mycobacterium bovis BCG str. Tokyo 172 7560727 YP_002644484.1 CDS metK NC_012207.1 1564871 1566082 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1564871..1566082 Mycobacterium bovis BCG str. Tokyo 172 7561489 YP_002644485.1 CDS JTY_1429 NC_012207.1 1566155 1567633 R monooxygenase complement(1566155..1567633) Mycobacterium bovis BCG str. Tokyo 172 7564462 YP_002644486.1 CDS cyp132 NC_012207.1 1567630 1569015 R Differs from Rv1394c by 1aa, L135R in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cytochrome P450 132 complement(1567630..1569015) Mycobacterium bovis BCG str. Tokyo 172 7562200 YP_002644487.1 CDS JTY_1431 NC_012207.1 1569093 1570127 D transcriptional regulatory protein 1569093..1570127 Mycobacterium bovis BCG str. Tokyo 172 7563159 YP_002644488.1 CDS PE_PGRS25 NC_012207.1 1570173 1571531 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 372 bp deletion leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (452 aa versus 576 aa). Differs from Rv1396c by 2 aa, S66R, H300R in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; PE-PGRS family protein complement(1570173..1571531) Mycobacterium bovis BCG str. Tokyo 172 7562201 YP_002644489.1 CDS JTY_1433 NC_012207.1 1571786 1572187 R Differs from Rv1397c by 1aa, G103D in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1571786..1572187) Mycobacterium bovis BCG str. Tokyo 172 7561766 YP_002644490.1 CDS JTY_1434 NC_012207.1 1572184 1572441 R hypothetical protein complement(1572184..1572441) Mycobacterium bovis BCG str. Tokyo 172 7562202 YP_002644491.1 CDS lipH NC_012207.1 1572524 1573483 R Differs from Rv1399c and Mb1434c by 1aa, A46P in BCG Pasteur and BCG Tokyo; lipase complement(1572524..1573483) Mycobacterium bovis BCG str. Tokyo 172 7562203 YP_002644492.1 CDS lipI NC_012207.1 1573508 1574470 R lipase complement(1573508..1574470) Mycobacterium bovis BCG str. Tokyo 172 7562836 YP_002644493.1 CDS JTY_1437 NC_012207.1 1574604 1575206 D hypothetical protein 1574604..1575206 Mycobacterium bovis BCG str. Tokyo 172 7562837 YP_002644494.1 CDS priA NC_012207.1 1575287 1577254 D binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 1575287..1577254 Mycobacterium bovis BCG str. Tokyo 172 7562204 YP_002644495.1 CDS JTY_1439 NC_012207.1 1577272 1578096 R methyltransferase complement(1577272..1578096) Mycobacterium bovis BCG str. Tokyo 172 7560823 YP_002644496.1 CDS JTY_1440 NC_012207.1 1578265 1578747 D transcriptional regulatory protein 1578265..1578747 Mycobacterium bovis BCG str. Tokyo 172 7562205 YP_002644497.1 CDS JTY_1441 NC_012207.1 1578819 1579643 R methyltransferase complement(1578819..1579643) Mycobacterium bovis BCG str. Tokyo 172 7562206 YP_002644498.1 CDS fmt NC_012207.1 1579840 1580778 D modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1579840..1580778 Mycobacterium bovis BCG str. Tokyo 172 7562207 YP_002644499.1 CDS fmu NC_012207.1 1580775 1582148 D Differs from Rv1407 by 1aa, L427I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; fmu protein 1580775..1582148 Mycobacterium bovis BCG str. Tokyo 172 7563417 YP_002644500.1 CDS rpe NC_012207.1 1582173 1582871 D catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 1582173..1582871 Mycobacterium bovis BCG str. Tokyo 172 7563418 YP_002644501.1 CDS ribG NC_012207.1 1582868 1583887 D Differs from Rv1409 by 2aa, N30K, T71A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; diaminohydroxyphosphoribosylaminopyrimidine deaminase, 5-amino-6-(5-phosphoribosylamino) uracil reductase; riboflavin biosynthesis protein 1582868..1583887 Mycobacterium bovis BCG str. Tokyo 172 7561595 YP_002644502.1 CDS JTY_1446 NC_012207.1 1583884 1585440 R P55; aminoglycosides/tetracycline-transport integral membrane protein complement(1583884..1585440) Mycobacterium bovis BCG str. Tokyo 172 7561576 YP_002644503.1 CDS lprG NC_012207.1 1585446 1586156 R lipoprotein complement(1585446..1586156) Mycobacterium bovis BCG str. Tokyo 172 7562208 YP_002644504.1 CDS ribC NC_012207.1 1586241 1586846 D catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1586241..1586846 Mycobacterium bovis BCG str. Tokyo 172 7560525 YP_002644505.1 CDS JTY_1449 NC_012207.1 1587060 1587575 D hypothetical protein 1587060..1587575 Mycobacterium bovis BCG str. Tokyo 172 7561573 YP_002644506.1 CDS JTY_1450 NC_012207.1 1587565 1587966 D hypothetical protein 1587565..1587966 Mycobacterium bovis BCG str. Tokyo 172 7562209 YP_002644507.1 CDS ribA2 NC_012207.1 1588071 1589348 D bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein 1588071..1589348 Mycobacterium bovis BCG str. Tokyo 172 7562210 YP_002644508.1 CDS ribH NC_012207.1 1589363 1589827 D RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 1589363..1589827 Mycobacterium bovis BCG str. Tokyo 172 7561572 YP_002644509.1 CDS JTY_1453 NC_012207.1 1589824 1590288 D hypothetical protein 1589824..1590288 Mycobacterium bovis BCG str. Tokyo 172 7561577 YP_002644510.1 CDS lprH NC_012207.1 1590313 1590999 D lipoprotein 1590313..1590999 Mycobacterium bovis BCG str. Tokyo 172 7562211 YP_002644511.1 CDS JTY_1455 NC_012207.1 1591179 1591652 D hypothetical protein 1591179..1591652 Mycobacterium bovis BCG str. Tokyo 172 7560526 YP_002644512.1 CDS uvrC NC_012207.1 1591716 1593656 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 1591716..1593656 Mycobacterium bovis BCG str. Tokyo 172 7562212 YP_002644513.1 CDS JTY_1457 NC_012207.1 1593653 1594558 D hypothetical protein 1593653..1594558 Mycobacterium bovis BCG str. Tokyo 172 7561674 YP_002644514.1 CDS JTY_1458 NC_012207.1 1594555 1595583 D Differs from Mb1457 by 1aa, A86V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1594555..1595583 Mycobacterium bovis BCG str. Tokyo 172 7562213 YP_002644515.1 CDS whiA NC_012207.1 1595580 1596557 D transcriptional regulatory protein 1595580..1596557 Mycobacterium bovis BCG str. Tokyo 172 7562214 YP_002644516.1 CDS JTY_1460 NC_012207.1 1596567 1597328 R hypothetical protein complement(1596567..1597328) Mycobacterium bovis BCG str. Tokyo 172 7561688 YP_002644517.1 CDS JTY_1461 NC_012207.1 1597332 1598711 D Differs from Rv1425 by 1aa, L343P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1597332..1598711 Mycobacterium bovis BCG str. Tokyo 172 7562215 YP_002644518.1 CDS lipO NC_012207.1 1598733 1599995 R esterase complement(1598733..1599995) Mycobacterium bovis BCG str. Tokyo 172 7562216 YP_002644519.1 CDS fadD12 NC_012207.1 1599995 1601602 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(1599995..1601602) Mycobacterium bovis BCG str. Tokyo 172 7562842 YP_002644520.1 CDS JTY_1464 NC_012207.1 1601606 1602433 R hypothetical protein complement(1601606..1602433) Mycobacterium bovis BCG str. Tokyo 172 7562918 YP_002644521.1 CDS JTY_1465 NC_012207.1 1602552 1603820 D hypothetical protein 1602552..1603820 Mycobacterium bovis BCG str. Tokyo 172 7562217 YP_002644522.1 CDS PE16 NC_012207.1 1604060 1605646 D PE family protein 1604060..1605646 Mycobacterium bovis BCG str. Tokyo 172 7562218 YP_002644523.1 CDS JTY_1467 NC_012207.1 1605757 1607526 D Differs from Rv1431 by 2aa, T65N, Q455K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1605757..1607526 Mycobacterium bovis BCG str. Tokyo 172 7561716 YP_002644524.1 CDS JTY_1468 NC_012207.1 1607523 1608944 D dehydrogenase 1607523..1608944 Mycobacterium bovis BCG str. Tokyo 172 7562219 YP_002644525.1 CDS JTY_1469 NC_012207.1 1609108 1609929 D Differs from Rv1433 and Mb1468 at C-terminal end due to 1bp deletion at position equivalent to H37Rv 1612222-1612222 in Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 1609108..1609929 Mycobacterium bovis BCG str. Tokyo 172 7562220 YP_002644526.1 CDS JTY_1470 NC_012207.1 1609929 1610066 D hypothetical protein 1609929..1610066 Mycobacterium bovis BCG str. Tokyo 172 7562221 YP_002644527.1 CDS JTY_1471 NC_012207.1 1610015 1610644 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, an in-frame insertion of 21 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (209 aa versus 202 aa). Differs from Rv1435c by 1aa, T67A in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; proline, glycine, valine-rich hypothetical protein complement(1610015..1610644) Mycobacterium bovis BCG str. Tokyo 172 7562222 YP_002644528.1 CDS gap NC_012207.1 1611001 1612020 D glyceraldehyde 3-phosphate dehydrogenase 1611001..1612020 Mycobacterium bovis BCG str. Tokyo 172 7562223 YP_002644529.1 CDS pgk NC_012207.1 1612023 1613261 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 1612023..1613261 Mycobacterium bovis BCG str. Tokyo 172 7561902 YP_002644530.1 CDS tpiA NC_012207.1 1613258 1614043 D Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1613258..1614043 Mycobacterium bovis BCG str. Tokyo 172 7562399 YP_002644531.1 CDS JTY_1475 NC_012207.1 1614655 1615080 R hypothetical protein complement(1614655..1615080) Mycobacterium bovis BCG str. Tokyo 172 7561864 YP_002644532.1 CDS secG NC_012207.1 1615531 1615764 D preprotein translocase subunit SecG 1615531..1615764 Mycobacterium bovis BCG str. Tokyo 172 7562224 YP_002644533.1 CDS PE_PGRS26 NC_012207.1 1615903 1617378 R Differs from Rv1441c by 1aa G236D and from Mb1476c by 1aa T354N in BCG Pasteur and BCG Tokyo; PE-PGRS family protein complement(1615903..1617378) Mycobacterium bovis BCG str. Tokyo 172 7560776 YP_002644534.1 CDS bisC NC_012207.1 1617485 1619785 D biotin sulfoxide reductase 1617485..1619785 Mycobacterium bovis BCG str. Tokyo 172 7561767 YP_002644535.1 CDS JTY_1479 NC_012207.1 1619901 1620386 R hypothetical protein complement(1619901..1620386) Mycobacterium bovis BCG str. Tokyo 172 7562072 YP_002644536.1 CDS JTY_1480 NC_012207.1 1620993 1621403 R hypothetical protein complement(1620993..1621403) Mycobacterium bovis BCG str. Tokyo 172 7562225 YP_002644537.1 CDS devB NC_012207.1 1621420 1622163 R 6-phosphogluconolactonase complement(1621420..1622163) Mycobacterium bovis BCG str. Tokyo 172 7562226 YP_002644538.1 CDS opcA NC_012207.1 1622160 1623071 R Differs from Rv1446v by 1aa P192R in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; OxpP cycle protein complement(1622160..1623071) Mycobacterium bovis BCG str. Tokyo 172 7561486 YP_002644539.1 CDS zwf2 NC_012207.1 1623124 1624668 R catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase complement(1623124..1624668) Mycobacterium bovis BCG str. Tokyo 172 7562495 YP_002644540.1 CDS tal NC_012207.1 1624665 1625786 R catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase complement(1624665..1625786) Mycobacterium bovis BCG str. Tokyo 172 7561458 YP_002644541.1 CDS tkt NC_012207.1 1625803 1627905 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(1625803..1627905) Mycobacterium bovis BCG str. Tokyo 172 7561821 YP_002644542.1 CDS PE_PGRS27 NC_012207.1 1628344 1632543 R In Mycobacterium bovis, insertions of 27 bp, 207 bpand 27 bp, substitutions of 60 bp to 63 bp and 11 bp, and a 27 bp deletion, leads to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (1408 aa versus 1329 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, one 27bp-insertion is missing, leading to a product of 1399 aa; PE-PGRS family protein complement(1628344..1632543) Mycobacterium bovis BCG str. Tokyo 172 7561860 YP_002644543.1 CDS ctaB NC_012207.1 1632945 1633871 D converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 1632945..1633871 Mycobacterium bovis BCG str. Tokyo 172 7561768 YP_002644544.1 CDS PE_PGRS28 NC_012207.1 1633920 1636142 R In Mycobacterium bovis BCG Pasteur and Tokyo, a insertion of 51 bp, several substitutions and a deletion of 207 bp, lead to a smaller product compared to its homolog Mycobacterium bovis (740 aa versus 795 aa). Differs from BCG_1513c by 5aa, G647D, G648I, D649I, G650V, T651A in BCG Tokyo.; PE-PGRS family protein complement(1633920..1636142) Mycobacterium bovis BCG str. Tokyo 172 7563127 YP_002644545.1 CDS JTY_1489 NC_012207.1 1636294 1637559 D Differs from Rv1453 by 1aa Q405P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional activator protein 1636294..1637559 Mycobacterium bovis BCG str. Tokyo 172 7561769 YP_002644546.1 CDS qor NC_012207.1 1637587 1638573 R quinone reductase complement(1637587..1638573) Mycobacterium bovis BCG str. Tokyo 172 7562227 YP_002644547.1 CDS JTY_1491 NC_012207.1 1638593 1639456 D hypothetical protein 1638593..1639456 Mycobacterium bovis BCG str. Tokyo 172 7561548 YP_002644548.1 CDS JTY_1492 NC_012207.1 1639406 1640338 R unidentified antibiotic-transport integral membrane ABC transporter complement(1639406..1640338) Mycobacterium bovis BCG str. Tokyo 172 7562228 YP_002644549.1 CDS JTY_1493 NC_012207.1 1640450 1641235 R unidentified antibiotic-transport integral membrane ABC transporter complement(1640450..1641235) Mycobacterium bovis BCG str. Tokyo 172 7562229 YP_002644550.1 CDS JTY_1494 NC_012207.1 1641232 1642173 R unidentified antibiotic-transport ATP-binding protein ABC transporter complement(1641232..1642173) Mycobacterium bovis BCG str. Tokyo 172 7562230 YP_002644551.1 CDS JTY_1495 NC_012207.1 1642329 1644104 R Differs from Rv1459c by 1aa, E113K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein complement(1642329..1644104) Mycobacterium bovis BCG str. Tokyo 172 7562231 YP_002644552.1 CDS JTY_1496 NC_012207.1 1644152 1644958 D Differs from Rv1460 by 2aa, F198I, V265 and from Mb1495 by 1aa, F198I in BCG Paasteur and BCG Tokyo; transcriptional regulatory protein 1644152..1644958 Mycobacterium bovis BCG str. Tokyo 172 7562232 YP_002644553.1 CDS JTY_1497 NC_012207.1 1644955 1647495 D hypothetical protein 1644955..1647495 Mycobacterium bovis BCG str. Tokyo 172 7562233 YP_002644554.1 CDS JTY_1498 NC_012207.1 1647492 1648685 D Differs from Rv1462 by 1aa, D183N in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1647492..1648685 Mycobacterium bovis BCG str. Tokyo 172 7562234 YP_002644555.1 CDS JTY_1499 NC_012207.1 1648682 1649482 D ATP-binding protein ABC transporter 1648682..1649482 Mycobacterium bovis BCG str. Tokyo 172 7562235 YP_002644556.1 CDS csd NC_012207.1 1649484 1650737 D cysteine desulfurase 1649484..1650737 Mycobacterium bovis BCG str. Tokyo 172 7562236 YP_002644557.1 CDS JTY_1501 NC_012207.1 1650734 1651222 D nitrogen fixation related protein 1650734..1651222 Mycobacterium bovis BCG str. Tokyo 172 7563123 YP_002644558.1 CDS JTY_1502 NC_012207.1 1651197 1651544 D hypothetical protein 1651197..1651544 Mycobacterium bovis BCG str. Tokyo 172 7562237 YP_002644559.1 CDS fadE15 NC_012207.1 1651639 1653468 R acyl-CoA dehydrogenase complement(1651639..1653468) Mycobacterium bovis BCG str. Tokyo 172 7562238 YP_002644560.1 CDS PE_PGRS29 NC_012207.1 1653575 1654687 R PE-PGRS family protein complement(1653575..1654687) Mycobacterium bovis BCG str. Tokyo 172 7563363 YP_002644561.1 CDS ctpD NC_012207.1 1654929 1656902 D cation transporter P-type ATPase D 1654929..1656902 Mycobacterium bovis BCG str. Tokyo 172 7561770 YP_002644562.1 CDS trxA NC_012207.1 1656946 1657320 D thioredoxin 1656946..1657320 Mycobacterium bovis BCG str. Tokyo 172 7563134 YP_002644563.1 CDS trxB1 NC_012207.1 1657336 1657707 D thioredoxin 1657336..1657707 Mycobacterium bovis BCG str. Tokyo 172 7561638 YP_002644564.1 CDS echA12 NC_012207.1 1657729 1658586 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1657729..1658586 Mycobacterium bovis BCG str. Tokyo 172 7561639 YP_002644565.1 CDS JTY_1509 NC_012207.1 1658622 1660250 D macrolide-transport ATP-binding protein ABC transporter 1658622..1660250 Mycobacterium bovis BCG str. Tokyo 172 7561524 YP_002644566.1 CDS JTY_1510 NC_012207.1 1660347 1660538 D Differs from Rv1473A by 1aa, P60S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional regulatory protein 1660347..1660538 Mycobacterium bovis BCG str. Tokyo 172 7562239 YP_002644567.1 CDS JTY_1511 NC_012207.1 1660607 1661170 R transcriptional regulatory protein complement(1660607..1661170) Mycobacterium bovis BCG str. Tokyo 172 7562240 YP_002644568.1 CDS acn NC_012207.1 1661181 1664012 R Catalyzes the conversion of citrate to isocitrate; aconitate hydratase complement(1661181..1664012) Mycobacterium bovis BCG str. Tokyo 172 7562241 YP_002644569.1 CDS JTY_1513 NC_012207.1 1664170 1664730 D hypothetical protein 1664170..1664730 Mycobacterium bovis BCG str. Tokyo 172 7563930 YP_002644570.1 CDS JTY_1514 NC_012207.1 1664956 1666374 D hypothetical invasion protein 1664956..1666374 Mycobacterium bovis BCG str. Tokyo 172 7562242 YP_002644571.1 CDS JTY_1515 NC_012207.1 1666385 1667110 D hypothetical invasion protein 1666385..1667110 Mycobacterium bovis BCG str. Tokyo 172 7562243 YP_002644572.1 CDS moxR1 NC_012207.1 1667249 1668382 D transcriptional regulatory protein 1667249..1668382 Mycobacterium bovis BCG str. Tokyo 172 7562244 YP_002644573.1 CDS JTY_1517 NC_012207.1 1668379 1669332 D hypothetical protein 1668379..1669332 Mycobacterium bovis BCG str. Tokyo 172 7563547 YP_002644574.1 CDS JTY_1518 NC_012207.1 1669343 1670350 D Differs from Rv1481 and Mb1517 by 1aa, D254N in BCG Pasteur and BCG Tokyo; hypothetical protein 1669343..1670350 Mycobacterium bovis BCG str. Tokyo 172 7562245 YP_002644575.1 CDS JTY_1519 NC_012207.1 1670423 1671265 R hypothetical protein complement(1670423..1671265) Mycobacterium bovis BCG str. Tokyo 172 7562246 YP_002644576.1 CDS fabG1 NC_012207.1 1671406 1672149 D 3-oxoacyl-ACP reductase 1671406..1672149 Mycobacterium bovis BCG str. Tokyo 172 7562247 YP_002644577.1 CDS inhA NC_012207.1 1672168 1672977 D Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 1672168..1672977 Mycobacterium bovis BCG str. Tokyo 172 7562900 YP_002644578.1 CDS hemH NC_012207.1 1672983 1674017 D protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 1672983..1674017 Mycobacterium bovis BCG str. Tokyo 172 7562788 YP_002644579.1 CDS JTY_1523 NC_012207.1 1673983 1674849 R First 270 aa identical to Mb1522c and Rv1486c (but differs by 1aa, N198K), then frameshifts due to extra base, g, at position equivalent to Mycobacterium tuberculosis strain H37Rv position 1676073-1676074. 2GC in BCG Tokyo, 1GC in BCG Pasteur.; hypothetical protein complement(1673983..1674849) Mycobacterium bovis BCG str. Tokyo 172 7563306 YP_002644580.1 CDS JTY_1524 NC_012207.1 1674907 1675341 D hypothetical protein 1674907..1675341 Mycobacterium bovis BCG str. Tokyo 172 7562248 YP_002644581.1 CDS JTY_1525 NC_012207.1 1675363 1676508 D exported conserved protein 1675363..1676508 Mycobacterium bovis BCG str. Tokyo 172 7562249 YP_002644582.1 CDS JTY_1526 NC_012207.1 1676518 1676874 D hypothetical protein 1676518..1676874 Mycobacterium bovis BCG str. Tokyo 172 7562250 YP_002644583.1 CDS JTY_1527 NC_012207.1 1676908 1677138 D hypothetical protein 1676908..1677138 Mycobacterium bovis BCG str. Tokyo 172 7562251 YP_002644584.1 CDS JTY_1528 NC_012207.1 1677288 1678595 D hypothetical protein 1677288..1678595 Mycobacterium bovis BCG str. Tokyo 172 7562252 YP_002644585.1 CDS JTY_1529 NC_012207.1 1679174 1679932 R hypothetical protein complement(1679174..1679932) Mycobacterium bovis BCG str. Tokyo 172 7562253 YP_002644586.1 CDS mutA NC_012207.1 1680123 1681970 D methylmalonyl-CoA mutase small subunit 1680123..1681970 Mycobacterium bovis BCG str. Tokyo 172 7562254 YP_002644587.1 CDS mutB NC_012207.1 1681971 1684223 D MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 1681971..1684223 Mycobacterium bovis BCG str. Tokyo 172 7563579 YP_002644588.1 CDS JTY_1532 NC_012207.1 1684237 1684539 D Differs from Rv1494 and Mb1531 by 1aa, L12S in BCG Pasteur and BCG Tokyo; hypothetical protein 1684237..1684539 Mycobacterium bovis BCG str. Tokyo 172 7563580 YP_002644589.1 CDS JTY_1533 NC_012207.1 1684536 1684853 D hypothetical protein 1684536..1684853 Mycobacterium bovis BCG str. Tokyo 172 7562255 YP_002644590.1 CDS JTY_1534 NC_012207.1 1684850 1685854 D functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 1684850..1685854 Mycobacterium bovis BCG str. Tokyo 172 7562256 YP_002644591.1 CDS lipL NC_012207.1 1685907 1687196 D esterase 1685907..1687196 Mycobacterium bovis BCG str. Tokyo 172 7562257 YP_002644592.1 CDS JTY_1536 NC_012207.1 1687269 1687886 R Differs from Rv1498c by 1aa, H191R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methyltransferase complement(1687269..1687886) Mycobacterium bovis BCG str. Tokyo 172 7562839 YP_002644593.1 CDS JTY_1537 NC_012207.1 1688100 1688291 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (a-g) at the 5' start leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (63 aa versus 70 aa); hypothetical protein complement(1688100..1688291) Mycobacterium bovis BCG str. Tokyo 172 7562258 YP_002644594.1 CDS JTY_1538 NC_012207.1 1688373 1688771 D hypothetical protein 1688373..1688771 Mycobacterium bovis BCG str. Tokyo 172 7562259 YP_002644595.1 CDS JTY_1539 NC_012207.1 1688816 1689844 D Differs from Rv1500 and Mb1538 by 1aa, E45D in BCG Pasteur and BCG Tokyo; glycosyltransferase 1688816..1689844 Mycobacterium bovis BCG str. Tokyo 172 7562260 YP_002644596.1 CDS JTY_1540 NC_012207.1 1689856 1690677 D hypothetical protein 1689856..1690677 Mycobacterium bovis BCG str. Tokyo 172 7562261 YP_002644597.1 CDS JTY_1541 NC_012207.1 1690890 1691789 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, Rv1502 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (T-*), splits Rv1502 into 2 parts, Mb1540 and Mb1541. Differs from Rv1502 by 1aa, C213Y in BCG Pasteur and BCG Tokyo; hypothetical protein 1690890..1691789 Mycobacterium bovis BCG str. Tokyo 172 7562262 YP_002644598.1 CDS JTY_1542 NC_012207.1 1691962 1693110 R catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase complement(1691962..1693110) Mycobacterium bovis BCG str. Tokyo 172 7562263 YP_002644599.1 CDS JTY_1543 NC_012207.1 1693247 1693912 R In Mycobacterium tuberculosis strain H37Rv, Rv1503c and Rv1504c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transversion (T-G) leads to a single product. Differs from Rv1503c by 1aa, K316E in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1693247..1693912) Mycobacterium bovis BCG str. Tokyo 172 7562264 YP_002644600.1 CDS JTY_1544 NC_012207.1 1694105 1694869 D Differs from Rv1517 by 1aa, F188L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1694105..1694869 Mycobacterium bovis BCG str. Tokyo 172 7562265 YP_002644601.1 CDS JTY_1545 NC_012207.1 1694878 1695837 D Differs from Rv1518 by 2aa, R266S, L317M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1694878..1695837 Mycobacterium bovis BCG str. Tokyo 172 7562266 YP_002644602.1 CDS JTY_1546 NC_012207.1 1695967 1696236 D hypothetical protein 1695967..1696236 Mycobacterium bovis BCG str. Tokyo 172 7562267 YP_002644603.1 CDS JTY_1547 NC_012207.1 1696262 1697302 D sugar transferase 1696262..1697302 Mycobacterium bovis BCG str. Tokyo 172 7562268 YP_002644604.1 CDS fadD25 NC_012207.1 1697536 1699287 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1697536..1699287 Mycobacterium bovis BCG str. Tokyo 172 7562269 YP_002644605.1 CDS mmpL12 NC_012207.1 1699523 1702846 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transversion (C-A) creating a stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1107 aa versus 1146 aa). Differs from Rv1522c (1146 aa) by 1aa, P381S, and from Mb1549c, (1107 aa) by 2aa, T204A, S947N in BCG Pasteur and BCG Tokyo; transmembrane transport protein complement(1699523..1702846) Mycobacterium bovis BCG str. Tokyo 172 7562931 YP_002644606.1 CDS JTY_1550 NC_012207.1 1702887 1703930 D methyltransferase 1702887..1703930 Mycobacterium bovis BCG str. Tokyo 172 7564482 YP_002644607.1 CDS JTY_1551 NC_012207.1 1703960 1705204 D glycosyltransferase 1703960..1705204 Mycobacterium bovis BCG str. Tokyo 172 7562270 YP_002644608.1 CDS wbbL2 NC_012207.1 1705251 1706036 D rhamnosyl transferase 1705251..1706036 Mycobacterium bovis BCG str. Tokyo 172 7562271 YP_002644609.1 CDS JTY_1553 NC_012207.1 1706014 1707294 R glycosyltransferase complement(1706014..1707294) Mycobacterium bovis BCG str. Tokyo 172 7561687 YP_002644610.1 CDS pks5 NC_012207.1 1707317 1713643 R Differs from Rv1527c by 2aa, T532P, L1439F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; polyketide synthase complement(1707317..1713643) Mycobacterium bovis BCG str. Tokyo 172 7562272 YP_002644611.1 CDS papA4 NC_012207.1 1714187 1714684 R polyketide synthase associated protein complement(1714187..1714684) Mycobacterium bovis BCG str. Tokyo 172 7562121 YP_002644612.1 CDS fadD24 NC_012207.1 1714736 1716490 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1714736..1716490 Mycobacterium bovis BCG str. Tokyo 172 7562514 YP_002644613.1 CDS adh NC_012207.1 1716607 1717710 D Differs from Rv1530 and Mb1557 by 1aa, L330P in BCG Pasteur and BCG Tokyo; alcohol dehydrogenase 1716607..1717710 Mycobacterium bovis BCG str. Tokyo 172 7562930 YP_002644614.1 CDS JTY_1558 NC_012207.1 1717707 1718273 D hypothetical protein 1717707..1718273 Mycobacterium bovis BCG str. Tokyo 172 7563940 YP_002644615.1 CDS JTY_1559 NC_012207.1 1718350 1718784 R hypothetical protein complement(1718350..1718784) Mycobacterium bovis BCG str. Tokyo 172 7562273 YP_002644616.1 CDS JTY_1560 NC_012207.1 1718844 1719971 D hypothetical protein 1718844..1719971 Mycobacterium bovis BCG str. Tokyo 172 7562274 YP_002644617.1 CDS JTY_1561 NC_012207.1 1719968 1720645 D transcriptional regulator 1719968..1720645 Mycobacterium bovis BCG str. Tokyo 172 7562275 YP_002644618.1 CDS JTY_1562 NC_012207.1 1721210 1721446 D hypothetical protein 1721210..1721446 Mycobacterium bovis BCG str. Tokyo 172 7562276 YP_002644619.1 CDS ileS NC_012207.1 1721753 1724878 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase 1721753..1724878 Mycobacterium bovis BCG str. Tokyo 172 7562277 YP_002644620.1 CDS dinX NC_012207.1 1725090 1726481 D involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 1725090..1726481 Mycobacterium bovis BCG str. Tokyo 172 7563347 YP_002644621.1 CDS ansA NC_012207.1 1726446 1727426 R L-aparaginase complement(1726446..1727426) Mycobacterium bovis BCG str. Tokyo 172 7561496 YP_002644622.1 CDS lspA NC_012207.1 1727478 1728086 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1727478..1728086 Mycobacterium bovis BCG str. Tokyo 172 7563976 YP_002644623.1 CDS JTY_1567 NC_012207.1 1728079 1729005 D hypothetical protein 1728079..1729005 Mycobacterium bovis BCG str. Tokyo 172 7560536 YP_002644624.1 CDS lprI NC_012207.1 1729012 1729605 R lipoprotein complement(1729012..1729605) Mycobacterium bovis BCG str. Tokyo 172 7562278 YP_002644625.1 CDS glbN NC_012207.1 1729660 1730070 R hemoglobin complement(1729660..1730070) Mycobacterium bovis BCG str. Tokyo 172 7560527 YP_002644626.1 CDS JTY_1570 NC_012207.1 1730298 1731323 D fatty acyl-CoA reductase 1730298..1731323 Mycobacterium bovis BCG str. Tokyo 172 7561916 YP_002644627.1 CDS JTY_1571 NC_012207.1 1731328 1732131 D In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, Rv1544 and Mb1571 exist as a single gene. In BCG Tokyo exists same as Rv1544 and Mb1571. In Mycobacterium bovis BCG Pasteur, two genes exist as a result of a 10 bp deletion that has occurred at a position equivalent to H37Rv position 1746147-1746156I; ketoacyl reductase 1731328..1732131 Mycobacterium bovis BCG str. Tokyo 172 7562279 YP_002644628.1 CDS JTY_1572 NC_012207.1 1732153 1732380 D hypothetical protein 1732153..1732380 Mycobacterium bovis BCG str. Tokyo 172 7562280 YP_002644629.1 CDS JTY_1573 NC_012207.1 1732429 1732860 D hypothetical protein 1732429..1732860 Mycobacterium bovis BCG str. Tokyo 172 7562281 YP_002644630.1 CDS dnaE NC_012207.1 1732928 1736482 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 1732928..1736482 Mycobacterium bovis BCG str. Tokyo 172 7560548 YP_002644631.1 CDS PPE21 NC_012207.1 1736531 1738567 R Differs from Rv1548c by 1aa, G258D, and from Mb1575c by 1aa, V68A in BCG Pasteur and BCG Tokyo; PPE family protein complement(1736531..1738567) Mycobacterium bovis BCG str. Tokyo 172 7561501 YP_002644632.1 CDS fadD11 NC_012207.1 1738724 1740667 D In Mycobacterium tuberculosis strain H37Rv, Rv1549 and Rv1550 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, two single base insertions (*-C and *-C) lead to a single product. Differs from Rv1550 by 1aa, S362L in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; fatty-acid-CoA ligase 1738724..1740667 Mycobacterium bovis BCG str. Tokyo 172 7562158 YP_002644633.1 CDS plsB1 NC_012207.1 1740681 1742546 D PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 1740681..1742546 Mycobacterium bovis BCG str. Tokyo 172 7562917 YP_002644634.1 CDS frdA NC_012207.1 1742916 1744667 D part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 1742916..1744667 Mycobacterium bovis BCG str. Tokyo 172 7562128 YP_002644635.1 CDS frdB NC_012207.1 1744670 1745422 D In Mycobacterium tuberculosis strain H37Rv, Rv1553 and Rv1554 exist as 2 genes. In Mycobacterium bovis (Mb1579), a 4bp insertion (*-GGGG) leads to a single product and in Mycobacterium bovis BCG Pasteur a 10 bp insertion at position equivalent to H37Rv 1760171-1760172 leads to insertion of two additional Gly codons. In Mycobacterium bovis BCG Tokyo, a 9 bp insertion at position equivalent to H37Rv 1760171-1760172 leads to insertion of three additional Gly codons. 16Gs in BCG Tokyo, 17Gs in BCG Pasteur.; iron-sulfur subunit frdB; fumarate reductase 1744670..1745422 Mycobacterium bovis BCG str. Tokyo 172 7563429 YP_002644636.1 CDS frdC NC_012207.1 1745485 1745799 D In Mycobacterium tuberculosis strain H37Rv, Rv1553 and Rv1554 exist as 2 genes. In Mycobacterium bovis, a 4bp insertion (*-GGGG) leads to a single product and in Mycobacterium bovis BCG Pasteur a 10 bp insertion at position equivalent to H37Rv 1760171-1760172 leads to insertion of two additional Gly codons. In Mycobacterium bovis BCG Tokyo, a 9 bp insertion at position equivalent to H37Rv 1760171-1760172 leads to insertion of three additional Gly codons.; membrane anchor subunit; fumarate reductase 1745485..1745799 Mycobacterium bovis BCG str. Tokyo 172 7561872 YP_002644637.1 CDS frdD NC_012207.1 1745796 1746173 D in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 1745796..1746173 Mycobacterium bovis BCG str. Tokyo 172 7561873 YP_002644638.1 CDS JTY_1582 NC_012207.1 1746241 1746849 D regulatory protein 1746241..1746849 Mycobacterium bovis BCG str. Tokyo 172 7561874 YP_002644639.1 CDS mmpS6 NC_012207.1 1746988 1747434 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 2153 bp insertion leads to a new protein with no equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to the TbD1 region; hypothetical protein 1746988..1747434 Mycobacterium bovis BCG str. Tokyo 172 7560549 YP_002644640.1 CDS mmpL6 NC_012207.1 1747431 1750334 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 2153 bp insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Belongs to the TbD1 region; transmembrane transport protein 1747431..1750334 Mycobacterium bovis BCG str. Tokyo 172 7563516 YP_002644641.1 CDS JTY_1585 NC_012207.1 1750344 1750790 D hypothetical protein 1750344..1750790 Mycobacterium bovis BCG str. Tokyo 172 7564491 YP_002644642.1 CDS ilvA NC_012207.1 1750825 1752114 D catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 1750825..1752114 Mycobacterium bovis BCG str. Tokyo 172 7560550 YP_002644643.1 CDS JTY_1587 NC_012207.1 1752152 1752370 D hypothetical protein 1752152..1752370 Mycobacterium bovis BCG str. Tokyo 172 7562775 YP_002644644.1 CDS JTY_1588 NC_012207.1 1752376 1752780 D hypothetical protein 1752376..1752780 Mycobacterium bovis BCG str. Tokyo 172 7560551 YP_002644645.1 CDS treZb NC_012207.1 1752797 1753357 R In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, treZa and treZb exist as a single gene, treZ. In Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base deletion at position equivalent to H37Rv 1766233-1766233 leads to frameshift and two genes, treZa and treZb; maltooligosyltrehalose trehalohydrolase complement(1752797..1753357) Mycobacterium bovis BCG str. Tokyo 172 7560552 YP_002644646.1 CDS treZa NC_012207.1 1753354 1754538 R In Mycobacterium tuberculosis strain H37Rv, and Mycobacterium bovis, treZa and treZb exist as a single gene, treZ. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, a single base deletion at position equivalent to H37Rv 1766233-1766233 leads to frameshift and two genes, treZa and treZb; maltooligosyltrehalose trehalohydrolase complement(1753354..1754538) Mycobacterium bovis BCG str. Tokyo 172 7561625 YP_002644647.1 CDS treY NC_012207.1 1754531 1756828 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and in Mycobacterium tuberculosis strain H37Rv, treY exists as a single gene. In Mycobacterium bovis, a large deletion of 806 bp, RD17, splits Rv1563c into two parts, treYa and treYb; maltooligosyltrehalose synthase complement(1754531..1756828) Mycobacterium bovis BCG str. Tokyo 172 7561871 YP_002644648.1 CDS treX NC_012207.1 1756832 1758997 R maltooligosyltrehalose synthase complement(1756832..1758997) Mycobacterium bovis BCG str. Tokyo 172 7561870 YP_002644649.1 CDS JTY_1593 NC_012207.1 1759036 1761225 R hypothetical protein complement(1759036..1761225) Mycobacterium bovis BCG str. Tokyo 172 7561869 YP_002644650.1 CDS JTY_1594 NC_012207.1 1761324 1762016 R inv protein complement(1761324..1762016) Mycobacterium bovis BCG str. Tokyo 172 7560553 YP_002644651.1 CDS JTY_1595 NC_012207.1 1762256 1762540 R hypothetical protein complement(1762256..1762540) Mycobacterium bovis BCG str. Tokyo 172 7560554 YP_002644652.1 CDS bioA NC_012207.1 1762788 1764101 D catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1762788..1764101 Mycobacterium bovis BCG str. Tokyo 172 7560555 YP_002644653.1 CDS bioF1 NC_012207.1 1764098 1765258 D catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 1764098..1765258 Mycobacterium bovis BCG str. Tokyo 172 7562066 YP_002644654.1 CDS bioD NC_012207.1 1765255 1765935 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1765255..1765935 Mycobacterium bovis BCG str. Tokyo 172 7562069 YP_002644655.1 CDS JTY_1599 NC_012207.1 1765935 1766444 D hypothetical protein 1765935..1766444 Mycobacterium bovis BCG str. Tokyo 172 7562068 YP_002644656.1 CDS JTY_1600 NC_012207.1 1766590 1767546 R In Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis, Rv1587c possibly exists as a pseudogene that has been disrupted when the phage entered. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, the prophage is absent and the C-terminal part of protein differs accordingly; partial REP13E12 repeat protein complement(1766590..1767546) Mycobacterium bovis BCG str. Tokyo 172 7560556 YP_002644657.1 CDS JTY_1601 NC_012207.1 1767317 1767985 R Differs from Rv1588c by 3aa, T63A, L91R, I131V; partial REP13E12 repeat protein complement(1767317..1767985) Mycobacterium bovis BCG str. Tokyo 172 7560557 YP_002644658.1 CDS bioB NC_012207.1 1768433 1769482 D catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase 1768433..1769482 Mycobacterium bovis BCG str. Tokyo 172 7560558 YP_002644659.1 CDS JTY_1603 NC_012207.1 1769483 1769722 D hypothetical protein 1769483..1769722 Mycobacterium bovis BCG str. Tokyo 172 7562067 YP_002644660.1 CDS JTY_1604 NC_012207.1 1769719 1770384 D transmembrane protein 1769719..1770384 Mycobacterium bovis BCG str. Tokyo 172 7560559 YP_002644661.1 CDS JTY_1605 NC_012207.1 1770549 1771889 R Differs from Rv1592c by 1aa, V322I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1770549..1771889) Mycobacterium bovis BCG str. Tokyo 172 7560560 YP_002644662.1 CDS JTY_1606 NC_012207.1 1772146 1772856 R hypothetical protein complement(1772146..1772856) Mycobacterium bovis BCG str. Tokyo 172 7560561 YP_002644663.1 CDS nadA NC_012207.1 1772905 1773954 D 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 1772905..1773954 Mycobacterium bovis BCG str. Tokyo 172 7560562 YP_002644664.1 CDS nadB NC_012207.1 1773954 1775537 D catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 1773954..1775537 Mycobacterium bovis BCG str. Tokyo 172 7563585 YP_002644665.1 CDS nadC NC_012207.1 1775537 1776394 D catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 1775537..1776394 Mycobacterium bovis BCG str. Tokyo 172 7563586 YP_002644666.1 CDS JTY_1610 NC_012207.1 1776443 1777201 D Differs from Rv1597 by 2aa, D21G, M93L, and from Mb1623 by 1aa, M93L in BCG Pasteur and BCG Tokyo; hypothetical protein 1776443..1777201 Mycobacterium bovis BCG str. Tokyo 172 7563587 YP_002644667.1 CDS JTY_1611 NC_012207.1 1777222 1777632 R hypothetical protein complement(1777222..1777632) Mycobacterium bovis BCG str. Tokyo 172 7560563 YP_002644668.1 CDS hisD NC_012207.1 1777732 1779048 D catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 1777732..1779048 Mycobacterium bovis BCG str. Tokyo 172 7560564 YP_002644669.1 CDS hisC1 NC_012207.1 1779045 1780187 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 1779045..1780187 Mycobacterium bovis BCG str. Tokyo 172 7563312 YP_002644670.1 CDS hisB NC_012207.1 1780184 1780816 D catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 1780184..1780816 Mycobacterium bovis BCG str. Tokyo 172 7563310 YP_002644671.1 CDS hisH NC_012207.1 1780813 1781433 D with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 1780813..1781433 Mycobacterium bovis BCG str. Tokyo 172 7563309 YP_002644672.1 CDS hisA NC_012207.1 1781443 1782180 D catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; phosphoribosyl isomerase A 1781443..1782180 Mycobacterium bovis BCG str. Tokyo 172 7563316 YP_002644673.1 CDS impA NC_012207.1 1782188 1783000 D Differs from Rv1604 by 3aa, H93Y, Q124P, L251P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; inositol-monophosphatase 1782188..1783000 Mycobacterium bovis BCG str. Tokyo 172 7563308 YP_002644674.1 CDS hisF NC_012207.1 1783002 1783805 D catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 1783002..1783805 Mycobacterium bovis BCG str. Tokyo 172 7562784 YP_002644675.1 CDS hisI NC_012207.1 1783802 1784149 D PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase 1783802..1784149 Mycobacterium bovis BCG str. Tokyo 172 7563314 YP_002644676.1 CDS chaA NC_012207.1 1784330 1785412 D ionic transporter integral membrane protein 1784330..1785412 Mycobacterium bovis BCG str. Tokyo 172 7563317 YP_002644677.1 CDS bcpB NC_012207.1 1785447 1785911 R peroxidoxin complement(1785447..1785911) Mycobacterium bovis BCG str. Tokyo 172 7562102 YP_002644678.1 CDS trpE NC_012207.1 1786052 1787602 D with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1786052..1787602 Mycobacterium bovis BCG str. Tokyo 172 7562061 YP_002644679.1 CDS JTY_1623 NC_012207.1 1787592 1788299 D hypothetical protein 1787592..1788299 Mycobacterium bovis BCG str. Tokyo 172 7561632 YP_002644680.1 CDS trpC NC_012207.1 1788389 1789207 D involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol phosphate synthase 1788389..1789207 Mycobacterium bovis BCG str. Tokyo 172 7560565 YP_002644681.1 CDS trpB NC_012207.1 1789276 1790508 D catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1789276..1790508 Mycobacterium bovis BCG str. Tokyo 172 7561630 YP_002644682.1 CDS trpA NC_012207.1 1790508 1791320 D catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1790508..1791320 Mycobacterium bovis BCG str. Tokyo 172 7561629 YP_002644683.1 CDS lgt NC_012207.1 1791320 1792726 D transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1791320..1792726 Mycobacterium bovis BCG str. Tokyo 172 7561628 YP_002644684.1 CDS JTY_1628 NC_012207.1 1793402 1793842 D hypothetical protein 1793402..1793842 Mycobacterium bovis BCG str. Tokyo 172 7562824 YP_002644685.1 CDS JTY_1629 NC_012207.1 1793832 1794230 D hypothetical protein 1793832..1794230 Mycobacterium bovis BCG str. Tokyo 172 7560566 YP_002644686.1 CDS pykA NC_012207.1 1794338 1795756 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1794338..1795756 Mycobacterium bovis BCG str. Tokyo 172 7560567 YP_002644687.1 CDS tesB1 NC_012207.1 1795764 1796666 D Differs from Rv1618 by 1aa, L121H in Mycobacterium tuberculosis CDC1331, Mycobacteoium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acyl-CoA thioesterase 1795764..1796666 Mycobacterium bovis BCG str. Tokyo 172 7560869 YP_002644688.1 CDS JTY_1632 NC_012207.1 1796724 1798178 D hypothetical protein 1796724..1798178 Mycobacterium bovis BCG str. Tokyo 172 7561840 YP_002644689.1 CDS cydC NC_012207.1 1798112 1799842 R 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein; ABC transporter complement(1798112..1799842) Mycobacterium bovis BCG str. Tokyo 172 7560568 YP_002644690.1 CDS cydD NC_012207.1 1799839 1801422 R 'component linked with the assembly of cytochrome' transport transmembrane ATP-binding protein; ABC transporter complement(1799839..1801422) Mycobacterium bovis BCG str. Tokyo 172 7563151 YP_002644691.1 CDS cydB NC_012207.1 1801509 1802549 R integral membrane cytochrome d ubiquinol oxidase subunit II complement(1801509..1802549) Mycobacterium bovis BCG str. Tokyo 172 7563152 YP_002644692.1 CDS cydA NC_012207.1 1802579 1804036 R integral membrane cytochrome d ubiquinol oxidase subunit I complement(1802579..1804036) Mycobacterium bovis BCG str. Tokyo 172 7563150 YP_002644693.1 CDS JTY_1637 NC_012207.1 1804147 1804734 R Differs from Rv1624c by 1aa, A178T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1804147..1804734) Mycobacterium bovis BCG str. Tokyo 172 7563149 YP_002644694.1 CDS cya NC_012207.1 1804763 1806019 R membrane-anchored adenylyl cyclase complement(1804763..1806019) Mycobacterium bovis BCG str. Tokyo 172 7560569 YP_002644695.1 CDS JTY_1639 NC_012207.1 1806329 1806946 D two-component system transcriptional regulator 1806329..1806946 Mycobacterium bovis BCG str. Tokyo 172 7562820 YP_002644696.1 CDS JTY_1640 NC_012207.1 1807014 1808222 R lipid-transfer protein complement(1807014..1808222) Mycobacterium bovis BCG str. Tokyo 172 7560570 YP_002644697.1 CDS JTY_1641 NC_012207.1 1808219 1808710 R Differs from Rv1628c and Mb1654c by 1aa, V93A in BCG Pasteur and BCG Tokyo; hypothetical protein complement(1808219..1808710) Mycobacterium bovis BCG str. Tokyo 172 7560571 YP_002644698.1 CDS polA NC_012207.1 1808814 1811528 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 1808814..1811528 Mycobacterium bovis BCG str. Tokyo 172 7560572 YP_002644699.1 CDS rpsA NC_012207.1 1811691 1813136 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1811691..1813136 Mycobacterium bovis BCG str. Tokyo 172 7562139 YP_002644700.1 CDS coaE NC_012207.1 1813162 1814385 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; in Mycobacterium tuberculosis the C-terminal UPF0157 domain appears to be necessary for proper folding of the N-terminal domain; dephospho-CoA kinase/protein folding accessory domain-containing protein 1813162..1814385 Mycobacterium bovis BCG str. Tokyo 172 7560728 YP_002644701.1 CDS JTY_1645 NC_012207.1 1814536 1814979 R hypothetical protein complement(1814536..1814979) Mycobacterium bovis BCG str. Tokyo 172 7563102 YP_002644702.1 CDS uvrB NC_012207.1 1815224 1817320 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1815224..1817320 Mycobacterium bovis BCG str. Tokyo 172 7560573 YP_002644703.1 CDS JTY_1647 NC_012207.1 1817317 1818732 D Differs from Rv1634 by 2aa, Q13E, R198G, and from Mb1660 by 1aa, Q13E in BCG Pasteur and BCG Tokyo; drug efflux membrane protein 1817317..1818732 Mycobacterium bovis BCG str. Tokyo 172 7561673 YP_002644704.1 CDS JTY_1648 NC_012207.1 1818721 1820391 R hypothetical protein complement(1818721..1820391) Mycobacterium bovis BCG str. Tokyo 172 7560574 YP_002644705.1 CDS TB15.3 NC_012207.1 1820600 1821040 D hypothetical protein 1820600..1821040 Mycobacterium bovis BCG str. Tokyo 172 7560575 YP_002644706.1 CDS JTY_1650 NC_012207.1 1821047 1821841 R hypothetical protein complement(1821047..1821841) Mycobacterium bovis BCG str. Tokyo 172 7561828 YP_002644707.1 CDS uvrA NC_012207.1 1821890 1824808 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 1821890..1824808 Mycobacterium bovis BCG str. Tokyo 172 7560576 YP_002644708.1 CDS JTY_1652 NC_012207.1 1824865 1825122 R hypothetical protein complement(1824865..1825122) Mycobacterium bovis BCG str. Tokyo 172 7561672 YP_002644709.1 CDS JTY_1653 NC_012207.1 1825138 1826607 R hypothetical protein complement(1825138..1826607) Mycobacterium bovis BCG str. Tokyo 172 7560577 YP_002644710.1 CDS lysS NC_012207.1 1826666 1830184 R catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase complement(1826666..1830184) Mycobacterium bovis BCG str. Tokyo 172 7560578 YP_002644711.1 CDS infC NC_012207.1 1830421 1831026 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 1830421..1831026 Mycobacterium bovis BCG str. Tokyo 172 7560541 YP_002644712.1 CDS rpmI NC_012207.1 1831076 1831270 D 50S ribosomal protein L35 1831076..1831270 Mycobacterium bovis BCG str. Tokyo 172 7562787 YP_002644713.1 CDS rplT NC_012207.1 1831332 1831721 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1831332..1831721 Mycobacterium bovis BCG str. Tokyo 172 7560722 YP_002644714.1 CDS tsnR NC_012207.1 1831754 1832536 D Differs from Rv1644 by 1aa, P232L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; 23S rRNA methyltransferase 1831754..1832536 Mycobacterium bovis BCG str. Tokyo 172 7561620 YP_002644715.1 CDS JTY_1659 NC_012207.1 1832547 1833602 R hypothetical protein complement(1832547..1833602) Mycobacterium bovis BCG str. Tokyo 172 7561643 YP_002644716.1 CDS PE17 NC_012207.1 1833912 1834844 D PE family protein 1833912..1834844 Mycobacterium bovis BCG str. Tokyo 172 7560579 YP_002644717.1 CDS JTY_1661 NC_012207.1 1834922 1835872 D Differs from Rv1647 by 1aa, P2A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 1834922..1835872 Mycobacterium bovis BCG str. Tokyo 172 7561717 YP_002644718.1 CDS JTY_1662 NC_012207.1 1835879 1836685 D transmembrane protein 1835879..1836685 Mycobacterium bovis BCG str. Tokyo 172 7560580 YP_002644719.1 CDS pheS NC_012207.1 1836881 1837906 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1836881..1837906 Mycobacterium bovis BCG str. Tokyo 172 7560581 YP_002644720.1 CDS pheT NC_012207.1 1837906 1840401 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1837906..1840401 Mycobacterium bovis BCG str. Tokyo 172 7562405 YP_002644721.1 CDS PE_PGRS30 NC_012207.1 1840495 1843551 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, an in-frame insertion of 21 bp leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1018 aa versus 1011 aa). Differs from Rv1651c by insertion of 7aa at position 152 and by 1aa, V179A in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; PE-PGRS family protein complement(1840495..1843551) Mycobacterium bovis BCG str. Tokyo 172 7562406 YP_002644722.1 CDS argC NC_012207.1 1843745 1844803 D catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 1843745..1844803 Mycobacterium bovis BCG str. Tokyo 172 7561772 YP_002644723.1 CDS argJ NC_012207.1 1844800 1846014 D bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein 1844800..1846014 Mycobacterium bovis BCG str. Tokyo 172 7563984 YP_002644724.1 CDS argB NC_012207.1 1846011 1846895 D catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 1846011..1846895 Mycobacterium bovis BCG str. Tokyo 172 7563989 YP_002644725.1 CDS argD NC_012207.1 1846892 1848094 D catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase 1846892..1848094 Mycobacterium bovis BCG str. Tokyo 172 7563983 YP_002644726.1 CDS argF NC_012207.1 1848091 1849014 D catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; ornithine carbamoyltransferase 1848091..1849014 Mycobacterium bovis BCG str. Tokyo 172 7563985 YP_002644727.1 CDS argR NC_012207.1 1849011 1849523 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 1849011..1849523 Mycobacterium bovis BCG str. Tokyo 172 7563986 YP_002644728.1 CDS argG NC_012207.1 1849532 1850728 D catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 1849532..1850728 Mycobacterium bovis BCG str. Tokyo 172 7563990 YP_002644729.1 CDS argH NC_012207.1 1850808 1852220 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 1850808..1852220 Mycobacterium bovis BCG str. Tokyo 172 7563987 YP_002644730.1 CDS pks10 NC_012207.1 1852329 1853390 D chalcone synthase 1852329..1853390 Mycobacterium bovis BCG str. Tokyo 172 7563988 YP_002644731.1 CDS pks7 NC_012207.1 1853473 1859853 D Differs from Rv1661 by 2aa, W670R, P1176S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; polyketide synthase 1853473..1859853 Mycobacterium bovis BCG str. Tokyo 172 7562441 YP_002644732.1 CDS pks8 NC_012207.1 1859873 1864678 D Differs from Rv1662 by 6aa, Y78D, deletion of V692, V807A, G1260R, T1356A, C1468Y, and from Mb1690 by 1aa, deletion of V692 in BCG Pasteur and BCG Tokyo; polyketide synthase 1859873..1864678 Mycobacterium bovis BCG str. Tokyo 172 7562124 YP_002644733.1 CDS pks17 NC_012207.1 1864678 1866186 D polyketide synthase 1864678..1866186 Mycobacterium bovis BCG str. Tokyo 172 7562125 YP_002644734.1 CDS pks9 NC_012207.1 1866192 1869245 D Differs from Rv1664 by 2aa, T36A, P350A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; polyketide synthase 1866192..1869245 Mycobacterium bovis BCG str. Tokyo 172 7562118 YP_002644735.1 CDS pks11 NC_012207.1 1869392 1870453 D chalcone synthase 1869392..1870453 Mycobacterium bovis BCG str. Tokyo 172 7562126 YP_002644736.1 CDS cyp139 NC_012207.1 1870436 1871728 R cytochrome P450 139 complement(1870436..1871728) Mycobacterium bovis BCG str. Tokyo 172 7562442 YP_002644737.1 CDS JTY_1681 NC_012207.1 1871743 1873518 R In Mycobacterium tuberculosis strain H37Rv, Rv1668c and Rv1667c exist as 2 genes with a small overlap between them. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 10 bp insertion (*-TCTTGCCGCG) leads to a single product; macrolide-transport ATP-binding protein ABC transporter complement(1871743..1873518) Mycobacterium bovis BCG str. Tokyo 172 7563165 YP_002644738.1 CDS JTY_1682 NC_012207.1 1873901 1874263 D hypothetical protein 1873901..1874263 Mycobacterium bovis BCG str. Tokyo 172 7560582 YP_002644739.1 CDS JTY_1683 NC_012207.1 1874296 1874643 D hypothetical protein 1874296..1874643 Mycobacterium bovis BCG str. Tokyo 172 7560583 YP_002644740.1 CDS JTY_1684 NC_012207.1 1874651 1875043 D hypothetical protein 1874651..1875043 Mycobacterium bovis BCG str. Tokyo 172 7560584 YP_002644741.1 CDS JTY_1685 NC_012207.1 1875052 1876383 R integral membrane transport protein complement(1875052..1876383) Mycobacterium bovis BCG str. Tokyo 172 7560585 YP_002644742.1 CDS JTY_1686 NC_012207.1 1876476 1877408 R hypothetical protein complement(1876476..1877408) Mycobacterium bovis BCG str. Tokyo 172 7560586 YP_002644743.1 CDS JTY_1687 NC_012207.1 1877436 1878092 R transcriptional regulatory protein complement(1877436..1878092) Mycobacterium bovis BCG str. Tokyo 172 7560587 YP_002644744.1 CDS JTY_1688 NC_012207.1 1878417 1879151 R Differs from Rv1675c by 1aa, A59V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional regulatory protein complement(1878417..1879151) Mycobacterium bovis BCG str. Tokyo 172 7560588 YP_002644745.1 CDS JTY_1689 NC_012207.1 1879223 1879927 D hypothetical protein 1879223..1879927 Mycobacterium bovis BCG str. Tokyo 172 7560589 YP_002644746.1 CDS dsbF NC_012207.1 1879924 1880472 D lipoprotein 1879924..1880472 Mycobacterium bovis BCG str. Tokyo 172 7560590 YP_002644747.1 CDS JTY_1691 NC_012207.1 1880573 1881475 D hypothetical protein 1880573..1881475 Mycobacterium bovis BCG str. Tokyo 172 7561517 YP_002644748.1 CDS fadE16 NC_012207.1 1881475 1882596 D acyl-CoA dehydrogenase 1881475..1882596 Mycobacterium bovis BCG str. Tokyo 172 7560591 YP_002644749.1 CDS JTY_1693 NC_012207.1 1882605 1883429 D Differs from Mb1707 by 1aa, A230G in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1882605..1883429 Mycobacterium bovis BCG str. Tokyo 172 7563364 YP_002644750.1 CDS moeX NC_012207.1 1883426 1884418 D molybdopterin biosynthesis protein 1883426..1884418 Mycobacterium bovis BCG str. Tokyo 172 7560592 YP_002644751.1 CDS JTY_1695 NC_012207.1 1884579 1885496 D coiled-coil structural protein 1884579..1885496 Mycobacterium bovis BCG str. Tokyo 172 7563544 YP_002644752.1 CDS JTY_1696 NC_012207.1 1885759 1888713 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1885759..1888713 Mycobacterium bovis BCG str. Tokyo 172 7560593 YP_002644753.1 CDS JTY_1697 NC_012207.1 1888706 1888930 D hypothetical protein 1888706..1888930 Mycobacterium bovis BCG str. Tokyo 172 7560594 YP_002644754.1 CDS JTY_1698 NC_012207.1 1888896 1889519 R hypothetical protein complement(1888896..1889519) Mycobacterium bovis BCG str. Tokyo 172 7560595 YP_002644755.1 CDS JTY_1699 NC_012207.1 1889521 1890201 R Differs from Rv1686c by 1aa, F20V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein ABC transporter complement(1889521..1890201) Mycobacterium bovis BCG str. Tokyo 172 7560596 YP_002644756.1 CDS JTY_1700 NC_012207.1 1890273 1891040 R ATP-binding protein ABC transporter complement(1890273..1891040) Mycobacterium bovis BCG str. Tokyo 172 7560597 YP_002644757.1 CDS JTY_1701 NC_012207.1 1891099 1891710 D responsible for recognizing base lesions in the genome and initiating base excision DNA repair; 3-methyladenine DNA glycosylase 1891099..1891710 Mycobacterium bovis BCG str. Tokyo 172 7560598 YP_002644758.1 CDS tyrS NC_012207.1 1891722 1892996 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1891722..1892996 Mycobacterium bovis BCG str. Tokyo 172 7560599 YP_002644759.1 CDS lprJ NC_012207.1 1893647 1894030 D In Mycobacterium bovis, a 2 bp insertion (*-AC) at the 5' end, leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis BCG Pasteur and BCG Tokyo (139 aa versus 127 aa); lipoprotein 1893647..1894030 Mycobacterium bovis BCG str. Tokyo 172 7561647 YP_002644760.1 CDS JTY_1704 NC_012207.1 1894069 1894821 D hypothetical protein 1894069..1894821 Mycobacterium bovis BCG str. Tokyo 172 7560528 YP_002644761.1 CDS JTY_1705 NC_012207.1 1894818 1895879 D phosphatase 1894818..1895879 Mycobacterium bovis BCG str. Tokyo 172 7560600 YP_002644762.1 CDS JTY_1706 NC_012207.1 1895876 1896052 D hypothetical protein 1895876..1896052 Mycobacterium bovis BCG str. Tokyo 172 7560601 YP_002644763.1 CDS tlyA NC_012207.1 1896060 1896866 D cytotoxin/hemolysin 1896060..1896866 Mycobacterium bovis BCG str. Tokyo 172 7560602 YP_002644764.1 CDS ppnK NC_012207.1 1896866 1897789 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1896866..1897789 Mycobacterium bovis BCG str. Tokyo 172 7561861 YP_002644765.1 CDS recN NC_012207.1 1897803 1899566 D DNA repair protein 1897803..1899566 Mycobacterium bovis BCG str. Tokyo 172 7560810 YP_002644766.1 CDS JTY_1710 NC_012207.1 1899662 1900843 D hypothetical protein 1899662..1900843 Mycobacterium bovis BCG str. Tokyo 172 7561560 YP_002644767.1 CDS JTY_1711 NC_012207.1 1900865 1901809 D hypothetical protein 1900865..1901809 Mycobacterium bovis BCG str. Tokyo 172 7560603 YP_002644768.1 CDS pyrG NC_012207.1 1901949 1903709 D CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1901949..1903709 Mycobacterium bovis BCG str. Tokyo 172 7560604 YP_002644769.1 CDS JTY_1713 NC_012207.1 1903702 1904325 D Differs from Mb1726 by 2aa, F43L, A202T in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1903702..1904325 Mycobacterium bovis BCG str. Tokyo 172 7560875 YP_002644770.1 CDS xerD NC_012207.1 1904322 1905257 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 1904322..1905257 Mycobacterium bovis BCG str. Tokyo 172 7560605 YP_002644771.1 CDS JTY_1715 NC_012207.1 1905331 1906695 R hypothetical protein complement(1905331..1906695) Mycobacterium bovis BCG str. Tokyo 172 7561697 YP_002644772.1 CDS JTY_1716 NC_012207.1 1907250 1907840 R Differs from Rv1703c and Mb1729c by 1aa, S48G in BCG Pasteur and BCG Tokyo; catechol-O-methyltransferase complement(1907250..1907840) Mycobacterium bovis BCG str. Tokyo 172 7560606 YP_002644773.1 CDS cycA NC_012207.1 1907905 1909575 R Differs from Rv1704c by 2aa, L93R, S122G, and from Mb1730c by 1aa, S122G in BCG Pasteur and BCG Tokyo; D-serine/alanine/glycine transporter protein complement(1907905..1909575) Mycobacterium bovis BCG str. Tokyo 172 7560607 YP_002644774.1 CDS PPE22 NC_012207.1 1909616 1910773 R Differs from Rv1705c by 2aa, A2D, V313L, and from Mb1731c by 1aa, A2D in BCG Pasteur. Differs from Rv1705c by 1aa, V313L in BCG Tokyo.; PPE family protein complement(1909616..1910773) Mycobacterium bovis BCG str. Tokyo 172 7563148 YP_002644775.1 CDS PPE23 NC_012207.1 1910813 1911997 R PPE family protein complement(1910813..1911997) Mycobacterium bovis BCG str. Tokyo 172 7562159 YP_002644776.1 CDS JTY_1720 NC_012207.1 1912601 1912768 R hypothetical protein complement(1912601..1912768) Mycobacterium bovis BCG str. Tokyo 172 7562160 YP_002644777.1 CDS JTY_1721 NC_012207.1 1913001 1914461 D Differs from Rv1707 by 1aa, Q438R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 1913001..1914461 Mycobacterium bovis BCG str. Tokyo 172 7560608 YP_002644778.1 CDS JTY_1722 NC_012207.1 1914479 1915435 D Differs from Rv1708 by 1a, a T56A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; initiation inhibitor protein 1914479..1915435 Mycobacterium bovis BCG str. Tokyo 172 7560609 YP_002644779.1 CDS JTY_1723 NC_012207.1 1915432 1916268 D hypothetical protein 1915432..1916268 Mycobacterium bovis BCG str. Tokyo 172 7560610 YP_002644780.1 CDS JTY_1724 NC_012207.1 1916265 1916960 D hypothetical protein 1916265..1916960 Mycobacterium bovis BCG str. Tokyo 172 7560611 YP_002644781.1 CDS JTY_1725 NC_012207.1 1916957 1917721 D hypothetical protein 1916957..1917721 Mycobacterium bovis BCG str. Tokyo 172 7560612 YP_002644782.1 CDS cmk NC_012207.1 1917718 1918410 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1917718..1918410 Mycobacterium bovis BCG str. Tokyo 172 7560613 YP_002644783.1 CDS engA NC_012207.1 1918407 1919798 D synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1918407..1919798 Mycobacterium bovis BCG str. Tokyo 172 7562116 YP_002644784.1 CDS JTY_1728 NC_012207.1 1919972 1920784 D oxidoreductase 1919972..1920784 Mycobacterium bovis BCG str. Tokyo 172 7562864 YP_002644785.1 CDS fadB3 NC_012207.1 1920778 1921692 D In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, Rv1715/fadB3 exists as a single gene. In Mycobacterium bovis, a single base transition (g-a) splits fadB3 into 2 parts, fadB3a and fadB3b; 3-hydroxybutyryl-CoA dehydrogenase 1920778..1921692 Mycobacterium bovis BCG str. Tokyo 172 7560614 YP_002644786.1 CDS JTY_1730 NC_012207.1 1921695 1922525 D Differs from Rv1716 by 2aa, G178S, A276V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 1921695..1922525 Mycobacterium bovis BCG str. Tokyo 172 7562912 YP_002644787.1 CDS JTY_1731 NC_012207.1 1922525 1922875 D hypothetical protein 1922525..1922875 Mycobacterium bovis BCG str. Tokyo 172 7560615 YP_002644788.1 CDS JTY_1732 NC_012207.1 1922928 1923551 D In Mycobacterium tuberculosis strain H37Rv, exists as a single gene. In Mycobacterium bovis AF2122/97, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base deletion (C-*) leads to a shorter product with a different COOH terminus; hypothetical protein 1922928..1923551 Mycobacterium bovis BCG str. Tokyo 172 7560616 YP_002644789.1 CDS JTY_1733 NC_012207.1 1923759 1924538 D transcriptional regulatory protein 1923759..1924538 Mycobacterium bovis BCG str. Tokyo 172 7560617 YP_002644790.1 CDS JTY_1734 NC_012207.1 1925148 1925537 R hypothetical protein complement(1925148..1925537) Mycobacterium bovis BCG str. Tokyo 172 7560828 YP_002644791.1 CDS JTY_1735 NC_012207.1 1925534 1925761 R hypothetical protein complement(1925534..1925761) Mycobacterium bovis BCG str. Tokyo 172 7560619 YP_002644792.1 CDS JTY_1736 NC_012207.1 1925979 1927463 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; biotin carboxylase-like protein 1925979..1927463 Mycobacterium bovis BCG str. Tokyo 172 7560620 YP_002644793.1 CDS JTY_1737 NC_012207.1 1927460 1928707 D hydrolase 1927460..1928707 Mycobacterium bovis BCG str. Tokyo 172 7560621 YP_002644794.1 CDS JTY_1738 NC_012207.1 1928750 1929169 R hypothetical protein complement(1928750..1929169) Mycobacterium bovis BCG str. Tokyo 172 7560622 YP_002644795.1 CDS JTY_1739 NC_012207.1 1929159 1929869 R hypothetical protein complement(1929159..1929869) Mycobacterium bovis BCG str. Tokyo 172 7560623 YP_002644796.1 CDS JTY_1740 NC_012207.1 1929970 1931355 D Differs from Rv1726 by 1aa, Y326H, and from Mb1755 by 1aa, A61P in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; oxidoreductase 1929970..1931355 Mycobacterium bovis BCG str. Tokyo 172 7560624 YP_002644797.1 CDS JTY_1741 NC_012207.1 1931388 1931957 D Differs from Rv1727 and Mb1756 by 1aa, D22E in BCG Pasteur and BCG Tokyo; hypothetical protein 1931388..1931957 Mycobacterium bovis BCG str. Tokyo 172 7560625 YP_002644798.1 CDS JTY_1742 NC_012207.1 1931982 1932752 R hypothetical protein complement(1931982..1932752) Mycobacterium bovis BCG str. Tokyo 172 7560626 YP_002644799.1 CDS JTY_1743 NC_012207.1 1932749 1933687 R hypothetical protein complement(1932749..1933687) Mycobacterium bovis BCG str. Tokyo 172 7560627 YP_002644800.1 CDS JTY_1744 NC_012207.1 1933753 1935306 R penicillin-binding protein complement(1933753..1935306) Mycobacterium bovis BCG str. Tokyo 172 7560628 YP_002644801.1 CDS gabD2 NC_012207.1 1935738 1937294 D NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinic semialdehyde dehydrogenase 1935738..1937294 Mycobacterium bovis BCG str. Tokyo 172 7560629 YP_002644802.1 CDS JTY_1746 NC_012207.1 1937304 1937852 R hypothetical protein complement(1937304..1937852) Mycobacterium bovis BCG str. Tokyo 172 7561892 YP_002644803.1 CDS JTY_1747 NC_012207.1 1937916 1938548 R Differs from Rv1733c by 1aa, H68Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein complement(1937916..1938548) Mycobacterium bovis BCG str. Tokyo 172 7563184 YP_002644804.1 CDS JTY_1748 NC_012207.1 1938835 1939077 R Differs from Mb1763c by 1aa, T79A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1938835..1939077) Mycobacterium bovis BCG str. Tokyo 172 7563185 YP_002644805.1 CDS JTY_1749 NC_012207.1 1939352 1939849 R hypothetical protein complement(1939352..1939849) Mycobacterium bovis BCG str. Tokyo 172 7563186 YP_002644806.1 CDS narX NC_012207.1 1940289 1942247 R Diffesr from Rv1736c by 2aa, H53D, G77D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; nitrate reductase complement(1940289..1942247) Mycobacterium bovis BCG str. Tokyo 172 7563187 YP_002644807.1 CDS narK2 NC_012207.1 1942244 1943431 R nitrate/nitrite transporter complement(1942244..1943431) Mycobacterium bovis BCG str. Tokyo 172 7562454 YP_002644808.1 CDS JTY_1752 NC_012207.1 1943718 1944002 D hypothetical protein 1943718..1944002 Mycobacterium bovis BCG str. Tokyo 172 7562450 YP_002644809.1 CDS JTY_1753 NC_012207.1 1944016 1945698 R Differs from Rv1739c by 1aa, L134R in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; sulphate-transport transmembrane protein ABC transporter complement(1944016..1945698) Mycobacterium bovis BCG str. Tokyo 172 7563188 YP_002644810.1 CDS JTY_1754 NC_012207.1 1945766 1945978 D hypothetical protein 1945766..1945978 Mycobacterium bovis BCG str. Tokyo 172 7563189 YP_002644811.1 CDS JTY_1755 NC_012207.1 1945978 1946226 D Differs from Rv1741 by 1aa, T67K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 1945978..1946226 Mycobacterium bovis BCG str. Tokyo 172 7563190 YP_002644812.1 CDS JTY_1756 NC_012207.1 1946307 1946972 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-C) leads to shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; hypothetical protein 1946307..1946972 Mycobacterium bovis BCG str. Tokyo 172 7563191 YP_002644813.1 CDS pknE NC_012207.1 1947066 1948766 D Differs from Mb1772 by 1aa, V56D in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; transmembrane serine/threonine-protein kinase E 1947066..1948766 Mycobacterium bovis BCG str. Tokyo 172 7563192 YP_002644814.1 CDS JTY_1758 NC_012207.1 1949051 1949452 R Differs from Rv1744c by 1aa, Q121R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1949051..1949452) Mycobacterium bovis BCG str. Tokyo 172 7562432 YP_002644815.1 CDS idi NC_012207.1 1949523 1950053 R catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase complement(1949523..1950053) Mycobacterium bovis BCG str. Tokyo 172 7563193 YP_002644816.1 CDS pknF NC_012207.1 1950200 1951630 D Differs from Rv1746 by 1aa, T325A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; anchored-membrane serine/threonine-protein kinase 1950200..1951630 Mycobacterium bovis BCG str. Tokyo 172 7563343 YP_002644817.1 CDS JTY_1761 NC_012207.1 1951692 1954289 D transmembrane ATP-binding protein ABC transporter 1951692..1954289 Mycobacterium bovis BCG str. Tokyo 172 7562433 YP_002644818.1 CDS JTY_1762 NC_012207.1 1954662 1955393 D hypothetical protein 1954662..1955393 Mycobacterium bovis BCG str. Tokyo 172 7563194 YP_002644819.1 CDS JTY_1763 NC_012207.1 1955390 1955947 R integral membrane protein complement(1955390..1955947) Mycobacterium bovis BCG str. Tokyo 172 7563195 YP_002644820.1 CDS fadD1 NC_012207.1 1956031 1957629 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(1956031..1957629) Mycobacterium bovis BCG str. Tokyo 172 7563196 YP_002644821.1 CDS JTY_1765 NC_012207.1 1957683 1959065 D Differs from Rv1751 by 2aa, T311M, L439V, and from Mb1780 by 1aa, T311M in BCG Pasteur and BCG Tokyo; hypothetical protein 1957683..1959065 Mycobacterium bovis BCG str. Tokyo 172 7562915 YP_002644822.1 CDS JTY_1766 NC_012207.1 1959192 1959641 D hypothetical protein 1959192..1959641 Mycobacterium bovis BCG str. Tokyo 172 7563197 YP_002644823.1 CDS PPE24 NC_012207.1 1959676 1962756 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, PPE24 differs in the 26 aa tandem repeat region, two copies less (in-frame deletion of 156 bp), and in the 25 aa repeat region, 2 and one more copies (in-frame insertion of 150bp and 75bp), respectively, compared to their homolog in Mycobacterium tuberculosis strain H37Rv; PPE family protein complement(1959676..1962756) Mycobacterium bovis BCG str. Tokyo 172 7563198 YP_002644824.1 CDS JTY_1768 NC_012207.1 1962960 1964651 R Differs from Rv1754c and Mb1783c by 1aa, S546N in BCG Pasteur and BCG Tokyo; hypothetical protein complement(1962960..1964651) Mycobacterium bovis BCG str. Tokyo 172 7562161 YP_002644825.1 CDS plcD NC_012207.1 1964835 1966379 R Truncated by RvD2 deletion (6804bp) in Mycobacterium tuberculosis strain H37Rv; phospholipase C 4 complement(1964835..1966379) Mycobacterium bovis BCG str. Tokyo 172 7563199 YP_002644826.1 CDS JTY_1770 NC_012207.1 1966508 1967692 R No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to the RvD2 region; hypothetical protein complement(1966508..1967692) Mycobacterium bovis BCG str. Tokyo 172 7562127 YP_002644827.1 CDS JTY_1771 NC_012207.1 1967842 1968981 D No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to RvD2 region; sulfite oxidase 1967842..1968981 Mycobacterium bovis BCG str. Tokyo 172 7563200 YP_002644828.1 CDS mmpL14 NC_012207.1 1969182 1972019 D No equivalent in Mycobacterium tuberculosis strain H37Rv. Belongs to RvD2 region; transmembrane transport protein 1969182..1972019 Mycobacterium bovis BCG str. Tokyo 172 7563201 YP_002644829.1 CDS cut1 NC_012207.1 1972340 1972996 D Belongs to the RvD2 region. In Mycobacterium tuberculosis strain H37Rv, Rv1758 is interrupted by IS6110 insertion element and the 5'-end is deleted; cutinase 1972340..1972996 Mycobacterium bovis BCG str. Tokyo 172 7564484 YP_002644830.1 CDS wag22b NC_012207.1 1973263 1975674 R In Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as a single gene. In Mycobacterium bovis BCG Pasteur and Tokyo, and Mycobacterium bovis, a single base deletion (C-*) splits wag22 into 2 parts, wag22a and wag22b. Differs from Mb1789c and Rv1759c by three deletions R129 replaced by AG, 5aa deletion at position 739 and 12aa deletion at position 777 making protein smaller (802 aa versus 820 aa) in BCG Pasteur. 5aa deletion at position 739 and 12aa deletion at position 777 making protein smaller (803 aa versus 820 aa) in BCG Tokyo.; PE-PGRS family protein complement(1973263..1975674) Mycobacterium bovis BCG str. Tokyo 172 7563142 YP_002644831.1 CDS wag22a NC_012207.1 1975671 1975955 R In Mycobacterium tuberculosis strain H37Rv, Rv1759c exists as a single gene. In Mycobacterium bovis BCG Pasteur and Tokyo, and Mycobacterium bovis, a single base deletion (C-*) splits wag22 into 2 parts, wag22a and wag22b. Differs from Mb1789c and Rv1759c by three deletions R129 replaced by AG, 5aa deletion at position 739 and 12aa deletion at position 777 making protein smaller (802 aa versus 820 aa) in BCG Pasteur. 5aa deletion at position 739 and 12aa deletion at position 777 making protein smaller (803 aa versus 820 aa) in BCG Tokyo.; PE-PGRS family protein complement(1975671..1975955) Mycobacterium bovis BCG str. Tokyo 172 7561684 YP_002644832.1 CDS JTY_1776 NC_012207.1 1976531 1978060 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (c-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Also differs from Rv1760 by 1aa, V219E; hypothetical protein 1976531..1978060 Mycobacterium bovis BCG str. Tokyo 172 7561683 YP_002644833.1 CDS JTY_1777 NC_012207.1 1978048 1978431 R hypothetical protein complement(1978048..1978431) Mycobacterium bovis BCG str. Tokyo 172 7563202 YP_002644834.1 CDS JTY_1778 NC_012207.1 1978431 1979219 R hypothetical protein complement(1978431..1979219) Mycobacterium bovis BCG str. Tokyo 172 7563203 YP_002644835.1 CDS JTY_1779 NC_012207.1 1979359 1979826 R In Mycobacterium tuberculosis strain H37Rv this region is occupied by IS6110 which interrupts the gene and appears to have deleted sequences downstream. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, there is an 848bp sequence that has replaced a 121bp sequence corresponding to H37Rv positions 1997332-1997452; hypothetical protein complement(1979359..1979826) Mycobacterium bovis BCG str. Tokyo 172 7563204 YP_002644836.1 CDS JTY_1780 NC_012207.1 1979924 1980076 R In Mycobacterium tuberculosis strain H37Rv this region is occupied by IS6110 which appears to have deleted sequences downstream. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, there is an 848bp sequence that has replaced a 121bp sequence corresponding to H37Rv positions 1997332-1997452; hypothetical protein complement(1979924..1980076) Mycobacterium bovis BCG str. Tokyo 172 7563205 YP_002644837.1 CDS JTY_1781 NC_012207.1 1980237 1981493 R In Mycobacterium bovis BCG Pasteur, deletion of 9068 bp (region of difference RD14), compared to Mycobacterium tuberculosis H37Rv (position: 1998226..2007293, 9068bp), Mycobacterium bovis AF2122/97 (position 1988666..1997751, 9086bp), and BCG Tokyo (position 1981204..1990289, 9086bp), removes genes Rv1765A-Rv1772 and merges truncated genes Rv1773c and Rv1765c in BCG Pasteur. Mycobacterium bovis (Mb1794c) and BCG Tokyo have a longer products to its homolg in Mycobacterium tuberculosis H37Rv (Rv1765c, 418 aa versus 365 aa).; hypothetical protein complement(1980237..1981493) Mycobacterium bovis BCG str. Tokyo 172 7563206 YP_002644838.1 CDS JTY_1782 NC_012207.1 1982120 1982335 R Equivqlent to Mycobacterium bovis (Mb1975c) and Mycobavterium tuberculosis H37Rv (Rv1765A) in Mycobacterium bovis BCG Tokyo; hypothetical protein complement(1982120..1982335) Mycobacterium bovis BCG str. Tokyo 172 7563207 YP_002644839.1 CDS JTY_1783 NC_012207.1 1982715 1982984 D Equivqlent to Mycobacterium bovis (Mb1975A) and Mycobavterium tuberculosis H37Rv (Rv1766) in Mycobacterium bovis BCG Tokyo; transposase 1982715..1982984 Mycobacterium bovis BCG str. Tokyo 172 7563208 YP_002644840.1 CDS JTY_1784 NC_012207.1 1983052 1983411 D Equivqlent to Mycobacterium bovis (Mb1796) and Mycobavterium tuberculosis H37Rv (Rv1767) in Mycobacterium bovis BCG Tokyo; hypothetical protein 1983052..1983411 Mycobacterium bovis BCG str. Tokyo 172 7563209 YP_002644841.1 CDS PE_PGRS31 NC_012207.1 1983592 1985466 D In Mycobacterium bovis and Mycobacterium BCG Tokyo, a 18bp insertion, leads to a longer product compared to its homolog in Mycobacterium tuberculosis H37Rv (624 aa versus 618 aa).; PE-PGRS family protein 1983592..1985466 Mycobacterium bovis BCG str. Tokyo 172 7563210 YP_002644842.1 CDS JTY_1786 NC_012207.1 1985622 1986866 D Equivqlent to Mycobacterium bovis (Mb1798) and Mycobavterium tuberculosis H37Rv (Rv1769) in Mycobacterium bovis BCG Tokyo; hypothetical protein 1985622..1986866 Mycobacterium bovis BCG str. Tokyo 172 7561773 YP_002644843.1 CDS JTY_1787 NC_012207.1 1986874 1988160 D Equivqlent to Mycobacterium bovis (Mb1799) and Mycobavterium tuberculosis H37Rv (Rv1770) in Mycobacterium bovis BCG Tokyo; hypothetical protein 1986874..1988160 Mycobacterium bovis BCG str. Tokyo 172 7563211 YP_002644844.1 CDS JTY_1788 NC_012207.1 1988157 1989443 D Equivqlent to Mycobacterium bovis (Mb1800) and Mycobavterium tuberculosis H37Rv (Rv1771) in Mycobacterium bovis BCG Tokyo; oxidoreductase 1988157..1989443 Mycobacterium bovis BCG str. Tokyo 172 7563212 YP_002644845.1 CDS JTY_1789 NC_012207.1 1989632 1989943 D Equivqlent to Mycobacterium bovis (Mb1801) and Mycobavterium tuberculosis H37Rv (Rv1772) in Mycobacterium bovis BCG Tokyo; hypothetical protein 1989632..1989943 Mycobacterium bovis BCG str. Tokyo 172 7563213 YP_002644846.1 CDS JTY_1790 NC_012207.1 1990016 1990762 R Equivqlent to Mycobacterium bovis (Mb1802c) and Mycobavterium tuberculosis H37Rv (Rv1773c) in Mycobacterium bovis BCG Tokyo; transcriptional regulatory protein complement(1990016..1990762) Mycobacterium bovis BCG str. Tokyo 172 7563214 YP_002644847.1 CDS JTY_1791 NC_012207.1 1990828 1992168 D oxidoreductase 1990828..1992168 Mycobacterium bovis BCG str. Tokyo 172 7563215 YP_002644848.1 CDS JTY_1792 NC_012207.1 1992168 1992986 D hypothetical protein 1992168..1992986 Mycobacterium bovis BCG str. Tokyo 172 7563216 YP_002644849.1 CDS JTY_1793 NC_012207.1 1992991 1993551 R transcriptional regulatory protein complement(1992991..1993551) Mycobacterium bovis BCG str. Tokyo 172 7563217 YP_002644850.1 CDS cyp144 NC_012207.1 1993652 1994956 D Differs from Rv1777 by 1aa Q325H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cytochrome p450 144 1993652..1994956 Mycobacterium bovis BCG str. Tokyo 172 7563218 YP_002644851.1 CDS JTY_1795 NC_012207.1 1995077 1995526 R Differs from Mb1807c by 1aa T32R in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(1995077..1995526) Mycobacterium bovis BCG str. Tokyo 172 7563170 YP_002644852.1 CDS JTY_1796 NC_012207.1 1995682 1997475 R hypothetical protein complement(1995682..1997475) Mycobacterium bovis BCG str. Tokyo 172 7563219 YP_002644853.1 CDS JTY_1797 NC_012207.1 1997695 1998258 D hypothetical protein 1997695..1998258 Mycobacterium bovis BCG str. Tokyo 172 7563220 YP_002644854.1 CDS malQ NC_012207.1 1998298 2000472 R Differs from Rv1781c and Mb1810c by 1aa, T12A in BCG Pasteur and BCG Tokyo; 4-alpha-glucanotransferase complement(1998298..2000472) Mycobacterium bovis BCG str. Tokyo 172 7563221 YP_002644855.1 CDS JTY_1799 NC_012207.1 2000736 2002256 D Differs from Rv1782 by 1aa H41R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2000736..2002256 Mycobacterium bovis BCG str. Tokyo 172 7560547 YP_002644856.1 CDS JTY_1800 NC_012207.1 2002253 2006428 D In Mycobacterium tuberculosis strain H37Rv, Rv1783 and Rv1784 exist as 2 genes. In Mycobacterium bovis and in Mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base transversion (a-t) leads to a single product. Differs from Rv1783 and Mb1812 by 1aa, V692A in BCG Pasteur, identical to Rv1784 in BCG Pasteur and Tokyo.; hypothetical protein 2002253..2006428 Mycobacterium bovis BCG str. Tokyo 172 7563222 YP_002644857.1 CDS cyp143 NC_012207.1 2006443 2007624 R cytochrome P450 143 complement(2006443..2007624) Mycobacterium bovis BCG str. Tokyo 172 7563223 YP_002644858.1 CDS JTY_1802 NC_012207.1 2007824 2008027 D ferredoxin 2007824..2008027 Mycobacterium bovis BCG str. Tokyo 172 7563169 YP_002644859.1 CDS PPE25 NC_012207.1 2008297 2009391 D In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 8 bp to 5 bp substitution (AGCCCGGT-CCGGG), leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (364 aa versus 365 aa). Identical to Mb1815; PPE family protein 2008297..2009391 Mycobacterium bovis BCG str. Tokyo 172 7563224 YP_002644860.1 CDS PE18 NC_012207.1 2009470 2009769 D PE family protein 2009470..2009769 Mycobacterium bovis BCG str. Tokyo 172 7562162 YP_002644861.1 CDS PPE26 NC_012207.1 2009783 2010964 D Differs from Mb1817 by 1aa, S274A, identical to Rv1789 in BCG Pasteur and BCG Tokyo; PPE family protein 2009783..2010964 Mycobacterium bovis BCG str. Tokyo 172 7561718 YP_002644862.1 CDS PPE27 NC_012207.1 2011418 2012470 D Identical to Rv1790 differs from Mb1818 by 1aa, P190S in BCG Pasteur and BCG Tokyo; PPE family protein 2011418..2012470 Mycobacterium bovis BCG str. Tokyo 172 7562163 YP_002644863.1 CDS PE19 NC_012207.1 2012897 2013196 D PE family protein 2012897..2013196 Mycobacterium bovis BCG str. Tokyo 172 7562164 YP_002644864.1 CDS esxM NC_012207.1 2013340 2013636 D Differs from Rv1792 by 1aa Q48M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2013340..2013636 Mycobacterium bovis BCG str. Tokyo 172 7561719 YP_002644865.1 CDS esxN NC_012207.1 2013687 2013971 D EsaT-6 like protein 5 2013687..2013971 Mycobacterium bovis BCG str. Tokyo 172 7562884 YP_002644866.1 CDS JTY_1810 NC_012207.1 2014059 2014961 D hypothetical protein 2014059..2014961 Mycobacterium bovis BCG str. Tokyo 172 7562885 YP_002644867.1 CDS JTY_1811 NC_012207.1 2015233 2016744 D Differs from Mb1823 and Rv1795 by 1aa, T256A and D261G, respectively, in BCG Pasteur and BCG Tokyo; hypothetical protein 2015233..2016744 Mycobacterium bovis BCG str. Tokyo 172 7563225 YP_002644868.1 CDS JTY_1812 NC_012207.1 2016722 2018479 D hypothetical pro-rich protease 2016722..2018479 Mycobacterium bovis BCG str. Tokyo 172 7563226 YP_002644869.1 CDS JTY_1813 NC_012207.1 2018476 2019696 D hypothetical protein 2018476..2019696 Mycobacterium bovis BCG str. Tokyo 172 7563227 YP_002644870.1 CDS JTY_1814 NC_012207.1 2019693 2021525 D hypothetical protein 2019693..2021525 Mycobacterium bovis BCG str. Tokyo 172 7563228 YP_002644871.1 CDS lppT NC_012207.1 2022152 2022343 D lipoprotein 2022152..2022343 Mycobacterium bovis BCG str. Tokyo 172 7563229 YP_002644872.1 CDS PPE28 NC_012207.1 2022446 2024413 D Differs from Rv1800 by 3aa, W144C, V253F, V432I, and from Mb1828 by 1aa, V432I in BCG Pasteur and BCG Tokyo; PPE family protein 2022446..2024413 Mycobacterium bovis BCG str. Tokyo 172 7560486 YP_002644873.1 CDS PPE29 NC_012207.1 2024994 2026265 D PPE family protein 2024994..2026265 Mycobacterium bovis BCG str. Tokyo 172 7562165 YP_002644874.1 CDS PPE30 NC_012207.1 2026377 2027768 D PPE family protein 2026377..2027768 Mycobacterium bovis BCG str. Tokyo 172 7562166 YP_002644875.1 CDS PE_PGRS32b NC_012207.1 2027916 2029538 R In Mycobacterium tuberculosis strain H37Rv, PE_PGRS32 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base transition (C-T) splits PE_PGRS32 into 2 parts, PE_PGRS32a and PE_PGRS32b; PE-PGRS family protein complement(2027916..2029538) Mycobacterium bovis BCG str. Tokyo 172 7562168 YP_002644876.1 CDS PE_PGRS32a NC_012207.1 2029572 2029835 R In Mycobacterium tuberculosis strain H37Rv, PE_PGRS32 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base transition (C-T) splits PE_PGRS32 into 2 parts, PE_PGRS32a and PE_PGRS32b; PE-PGRS family protein complement(2029572..2029835) Mycobacterium bovis BCG str. Tokyo 172 7561775 YP_002644877.1 CDS JTY_1821 NC_012207.1 2030016 2030342 R hypothetical protein complement(2030016..2030342) Mycobacterium bovis BCG str. Tokyo 172 7561774 YP_002644878.1 CDS JTY_1822 NC_012207.1 2030680 2031027 R hypothetical protein complement(2030680..2031027) Mycobacterium bovis BCG str. Tokyo 172 7563230 YP_002644879.1 CDS PE20 NC_012207.1 2031065 2031364 D PE family protein 2031065..2031364 Mycobacterium bovis BCG str. Tokyo 172 7563231 YP_002644880.1 CDS PPE31 NC_012207.1 2031379 2032590 D Differs from Rv1807 by 2aa, S223F, L234V. Identicalto Mb1836 in BCG Pasteur and BCG Tokyo; PPE family protein 2031379..2032590 Mycobacterium bovis BCG str. Tokyo 172 7561721 YP_002644881.1 CDS PPE32 NC_012207.1 2032914 2034143 D Differs from Rv1808 by 1aa, A301G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PPE family protein 2032914..2034143 Mycobacterium bovis BCG str. Tokyo 172 7562169 YP_002644882.1 CDS PPE33a NC_012207.1 2034275 2034838 D In Mycobacterium tuberculosis strain H37Rv, PPE33 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base transition (C-T) splits PPE33 into 2 parts, PPE33a and PPE33b; PPE Family protein 2034275..2034838 Mycobacterium bovis BCG str. Tokyo 172 7562170 YP_002644883.1 CDS JTY_1828 NC_012207.1 2035926 2036282 D hypothetical protein 2035926..2036282 Mycobacterium bovis BCG str. Tokyo 172 7562172 YP_002644884.1 CDS JTY_1829 NC_012207.1 2036436 2037140 D MgtC; Mg2+ transport P-type ATPase C 2036436..2037140 Mycobacterium bovis BCG str. Tokyo 172 7563232 YP_002644885.1 CDS JTY_1830 NC_012207.1 2037150 2038352 R Differs from Rv1812c by 1aa, P30L in Mycobacteium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; dehydrogenase complement(2037150..2038352) Mycobacterium bovis BCG str. Tokyo 172 7563233 YP_002644886.1 CDS JTY_1831 NC_012207.1 2038674 2039105 R hypothetical protein complement(2038674..2039105) Mycobacterium bovis BCG str. Tokyo 172 7563234 YP_002644887.1 CDS erg3 NC_012207.1 2039514 2040416 D membrane-bound C-5 sterol desaturase 2039514..2040416 Mycobacterium bovis BCG str. Tokyo 172 7563235 YP_002644888.1 CDS JTY_1833 NC_012207.1 2040521 2041186 D Differs from Rv1815 by 1aa, F83I in Mycobacteium tuberculosis CDC1551, Mycobacteium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 2040521..2041186 Mycobacterium bovis BCG str. Tokyo 172 7562873 YP_002644889.1 CDS JTY_1834 NC_012207.1 2041249 2041953 D transcriptional regulatory protein 2041249..2041953 Mycobacterium bovis BCG str. Tokyo 172 7563236 YP_002644891.1 CDS JTY_1836 NC_012207.1 2042588 2044051 D hypothetical protein 2042588..2044051 Mycobacterium bovis BCG str. Tokyo 172 7563238 YP_002644892.1 CDS PE_PGRS33 NC_012207.1 2044171 2045676 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 9 bp insertion (*-GCCGCCGGC), leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (501 aa versus 498 aa). Differs from Rv1818c by 4aa, S233G, and deletion of 3aa near C-terminus. Identical to Mb1849c; PE-PGRS family protein complement(2044171..2045676) Mycobacterium bovis BCG str. Tokyo 172 7563239 YP_002644893.1 CDS JTY_1838 NC_012207.1 2045811 2047730 R Differs from Rv1819c by 1aa, V603I in BCG Pasteur and BCG Tokyo; drugs-transport transmembrane ATP-binding protein ABC transporter complement(2045811..2047730) Mycobacterium bovis BCG str. Tokyo 172 7561776 YP_002644894.1 CDS ilvG NC_012207.1 2047801 2049444 D hypothetical protein 2047801..2049444 Mycobacterium bovis BCG str. Tokyo 172 7563240 YP_002644895.1 CDS secA2 NC_012207.1 2049459 2051885 D SecA2; functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond to SecA2; which is non-essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 2049459..2051885 Mycobacterium bovis BCG str. Tokyo 172 7562781 YP_002644896.1 CDS pgsA2 NC_012207.1 2052082 2052711 D CDP-diacylglycerol--glycerol-3- phosphate 3-phosphatidyltransferase 2052082..2052711 Mycobacterium bovis BCG str. Tokyo 172 7560771 YP_002644897.1 CDS JTY_1842 NC_012207.1 2052704 2053627 D hypothetical protein 2052704..2053627 Mycobacterium bovis BCG str. Tokyo 172 7562402 YP_002644898.1 CDS JTY_1843 NC_012207.1 2053656 2054021 D hypothetical protein 2053656..2054021 Mycobacterium bovis BCG str. Tokyo 172 7563241 YP_002644899.1 CDS JTY_1844 NC_012207.1 2054038 2054916 D hypothetical protein 2054038..2054916 Mycobacterium bovis BCG str. Tokyo 172 7563242 YP_002644900.1 CDS gcvH NC_012207.1 2054954 2055358 D part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 2054954..2055358 Mycobacterium bovis BCG str. Tokyo 172 7563243 YP_002644901.1 CDS cfp17 NC_012207.1 2055598 2056086 D hypothetical protein 2055598..2056086 Mycobacterium bovis BCG str. Tokyo 172 7561910 YP_002644902.1 CDS JTY_1847 NC_012207.1 2056083 2056826 D hypothetical protein 2056083..2056826 Mycobacterium bovis BCG str. Tokyo 172 7562097 YP_002644903.1 CDS JTY_1848 NC_012207.1 2056945 2057439 D Differs from Mb1860 by 1aa R93C in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 2056945..2057439 Mycobacterium bovis BCG str. Tokyo 172 7563244 YP_002644904.1 CDS JTY_1849 NC_012207.1 2057787 2058464 D hypothetical protein 2057787..2058464 Mycobacterium bovis BCG str. Tokyo 172 7563245 YP_002644905.1 CDS JTY_1850 NC_012207.1 2058517 2058774 D hypothetical protein 2058517..2058774 Mycobacterium bovis BCG str. Tokyo 172 7563246 YP_002644906.1 CDS gcvB NC_012207.1 2058823 2061648 D acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 2058823..2061648 Mycobacterium bovis BCG str. Tokyo 172 7563247 YP_002644907.1 CDS JTY_1852 NC_012207.1 2061875 2062735 R haloalkane dehalogenase complement(2061875..2062735) Mycobacterium bovis BCG str. Tokyo 172 7561909 YP_002644908.1 CDS JTY_1853 NC_012207.1 2062776 2063642 D Differs from Mb1865 by 1aa, V272A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrolase 2062776..2063642 Mycobacterium bovis BCG str. Tokyo 172 7563248 YP_002644909.1 CDS JTY_1854 NC_012207.1 2063647 2065533 R hypothetical protein complement(2063647..2065533) Mycobacterium bovis BCG str. Tokyo 172 7563249 YP_002644910.1 CDS JTY_1855 NC_012207.1 2065549 2067582 R Differs from Rv1836c by 2aa, C137R, H591R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2065549..2067582) Mycobacterium bovis BCG str. Tokyo 172 7563250 YP_002644911.1 CDS glcB NC_012207.1 2067702 2069927 R catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G complement(2067702..2069927) Mycobacterium bovis BCG str. Tokyo 172 7563251 YP_002644912.1 CDS JTY_1857 NC_012207.1 2070203 2070598 R hypothetical protein complement(2070203..2070598) Mycobacterium bovis BCG str. Tokyo 172 7561918 YP_002644913.1 CDS JTY_1858 NC_012207.1 2070595 2070858 R hypothetical protein complement(2070595..2070858) Mycobacterium bovis BCG str. Tokyo 172 7563252 YP_002644914.1 CDS PE_PGRS34a NC_012207.1 2071645 2072463 R In Mycobacterium bovis, an in-frame deletion of 147bp leads to a shorter protein compared to its homolog in Mycobacterium tuberculosis strain H37Rv (466 aa versus 518 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a deletion of 1bp, splits PPE34 into 2 parts, PPE34a and PPE34b; PE-PGRS family protein complement(2071645..2072463) Mycobacterium bovis BCG str. Tokyo 172 7561778 YP_002644915.1 CDS JTY_1861 NC_012207.1 2072626 2073675 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 12 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (349 aa versus 345 aa); hypothetical protein complement(2072626..2073675) Mycobacterium bovis BCG str. Tokyo 172 7561777 YP_002644916.1 CDS JTY_1862 NC_012207.1 2073675 2075042 R Differs from Rv1842c by 1aa, S437L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2073675..2075042) Mycobacterium bovis BCG str. Tokyo 172 7563254 YP_002644917.1 CDS guaB1 NC_012207.1 2075216 2076655 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase complement(2075216..2076655) Mycobacterium bovis BCG str. Tokyo 172 7563255 YP_002644918.1 CDS gnd1 NC_012207.1 2076021 2078078 R catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase complement(2076021..2078078) Mycobacterium bovis BCG str. Tokyo 172 7563288 YP_002644919.1 CDS JTY_1865 NC_012207.1 2078168 2079118 R Differs from Rv1845c and Mb1876c by 1aa, A222V in BCG Pasteur and BCG Tokyo; hypothetical protein complement(2078168..2079118) Mycobacterium bovis BCG str. Tokyo 172 7563272 YP_002644920.1 CDS JTY_1866 NC_012207.1 2079133 2079549 R Differs from Rv1846c by 1aa, Y92D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional regulatory protein complement(2079133..2079549) Mycobacterium bovis BCG str. Tokyo 172 7563256 YP_002644921.1 CDS JTY_1867 NC_012207.1 2079827 2080249 D Differs from Rv1847 by 1aa, L90V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2079827..2080249 Mycobacterium bovis BCG str. Tokyo 172 7563257 YP_002644922.1 CDS ureA NC_012207.1 2080298 2080600 D UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 2080298..2080600 Mycobacterium bovis BCG str. Tokyo 172 7563258 YP_002644923.1 CDS ureB NC_012207.1 2080597 2080911 D ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); urease subunit beta 2080597..2080911 Mycobacterium bovis BCG str. Tokyo 172 7561662 YP_002644924.1 CDS ureC NC_012207.1 2080911 2082644 D ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 2080911..2082644 Mycobacterium bovis BCG str. Tokyo 172 7561663 YP_002644925.1 CDS ureF NC_012207.1 2082644 2083279 D Differs from Rv1851 by 1aa, L34V in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; urease accessory protein 2082644..2083279 Mycobacterium bovis BCG str. Tokyo 172 7561664 YP_002644926.1 CDS ureG NC_012207.1 2083290 2083964 D urease accessory protein 2083290..2083964 Mycobacterium bovis BCG str. Tokyo 172 7561666 YP_002644927.1 CDS ureD NC_012207.1 2083972 2084598 D urease accessory protein 2083972..2084598 Mycobacterium bovis BCG str. Tokyo 172 7561667 YP_002644928.1 CDS ndh NC_012207.1 2084601 2085992 R Differs from Rv1854c by 1aa, R313G, and Mb1885c by 2aa, R284W, R313G in BCG Pasteur and BCG Tokyo; NADH dehydrogenase complement(2084601..2085992) Mycobacterium bovis BCG str. Tokyo 172 7561665 YP_002644929.1 CDS JTY_1875 NC_012207.1 2086133 2087056 R oxidoreductase complement(2086133..2087056) Mycobacterium bovis BCG str. Tokyo 172 7562456 YP_002644930.1 CDS JTY_1876 NC_012207.1 2087095 2087772 R Differs from Rv1856c by 1aa, H185R in BCG Pasteur and BCG Tokyo; short chain dehydrogenase complement(2087095..2087772) Mycobacterium bovis BCG str. Tokyo 172 7563259 YP_002644931.1 CDS modA NC_012207.1 2087934 2088719 D molybdate-binding lipoprotein 2087934..2088719 Mycobacterium bovis BCG str. Tokyo 172 7563260 YP_002644932.1 CDS modB NC_012207.1 2088722 2089516 D molbdenum-transport integral membrane protein ABC transporter 2088722..2089516 Mycobacterium bovis BCG str. Tokyo 172 7563536 YP_002644933.1 CDS modC NC_012207.1 2089523 2090632 D Differs from Rv1859 by 1aa, M313T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; molybdenum-transport ATP-binding protein ABC transporter 2089523..2090632 Mycobacterium bovis BCG str. Tokyo 172 7563537 YP_002644934.1 CDS apa NC_012207.1 2090685 2091662 D Differs from Rv1860 by 1aa, L136F in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2090685..2091662 Mycobacterium bovis BCG str. Tokyo 172 7563538 YP_002644935.1 CDS JTY_1881 NC_012207.1 2092114 2092419 D transmembrane protein 2092114..2092419 Mycobacterium bovis BCG str. Tokyo 172 7563980 YP_002644936.1 CDS adhA NC_012207.1 2092494 2093534 D alcohol dehydrogenase 2092494..2093534 Mycobacterium bovis BCG str. Tokyo 172 7563261 YP_002644937.1 CDS JTY_1883 NC_012207.1 2093541 2094311 R hypothetical protein complement(2093541..2094311) Mycobacterium bovis BCG str. Tokyo 172 7563941 YP_002644938.1 CDS JTY_1884 NC_012207.1 2094304 2095059 R hypothetical protein complement(2094304..2095059) Mycobacterium bovis BCG str. Tokyo 172 7563262 YP_002644939.1 CDS JTY_1885 NC_012207.1 2095056 2095916 R short chain dehydrogenase complement(2095056..2095916) Mycobacterium bovis BCG str. Tokyo 172 7563263 YP_002644940.1 CDS JTY_1886 NC_012207.1 2096090 2098426 D Differs from Rv1866 by 1aa, Q17E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2096090..2098426 Mycobacterium bovis BCG str. Tokyo 172 7563264 YP_002644941.1 CDS JTY_1887 NC_012207.1 2098714 2100198 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 2098714..2100198 Mycobacterium bovis BCG str. Tokyo 172 7563265 YP_002644942.1 CDS JTY_1888 NC_012207.1 2100297 2102396 D Differs from Rv1868 and Mb1899 by 1aa, G621D in BCG Pasteur and BCG Tokyo; hypothetical protein 2100297..2102396 Mycobacterium bovis BCG str. Tokyo 172 7560630 YP_002644943.1 CDS JTY_1889 NC_012207.1 2102410 2103645 R Differs from Mb1900c and Rv1869c by 1aa, P4S in BCG Pasteur and BCG Tokyo; reductase complement(2102410..2103645) Mycobacterium bovis BCG str. Tokyo 172 7560631 YP_002644944.1 CDS JTY_1890 NC_012207.1 2103712 2104380 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transversion (T-A) and a single base transition (C-T) lead to a slightly longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (222 aa versus 211 aa); hypothetical protein complement(2103712..2104380) Mycobacterium bovis BCG str. Tokyo 172 7560632 YP_002644945.1 CDS JTY_1891 NC_012207.1 2104445 2104834 R hypothetical protein complement(2104445..2104834) Mycobacterium bovis BCG str. Tokyo 172 7560633 YP_002644946.1 CDS lldD2 NC_012207.1 2104857 2106101 R Differs from Rv1872c by 2aa, A59G, A176V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cytochrome; L-lactate dehydrogenase complement(2104857..2106101) Mycobacterium bovis BCG str. Tokyo 172 7560634 YP_002644947.1 CDS JTY_1893 NC_012207.1 2106124 2106561 D Differs from Mb1904 by 1aa, D102N in BCG Pasteur and BCG Tokyo; hypothetical protein 2106124..2106561 Mycobacterium bovis BCG str. Tokyo 172 7562851 YP_002644948.1 CDS JTY_1894 NC_012207.1 2106634 2107320 D hypothetical protein 2106634..2107320 Mycobacterium bovis BCG str. Tokyo 172 7560635 YP_002644949.1 CDS JTY_1895 NC_012207.1 2107331 2107774 D hypothetical protein 2107331..2107774 Mycobacterium bovis BCG str. Tokyo 172 7560636 YP_002644950.1 CDS bfrA NC_012207.1 2108290 2108769 D bacterioferritin 2108290..2108769 Mycobacterium bovis BCG str. Tokyo 172 7560637 YP_002644951.1 CDS JTY_1897 NC_012207.1 2108854 2110389 D In Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-C), splits Rv1877 into 2 parts; integral membrane protein 2108854..2110389 Mycobacterium bovis BCG str. Tokyo 172 7562063 YP_002644952.1 CDS JTY_1898 NC_012207.1 2109704 2110918 D In Mycobacterium tuberculosis strain H37Rv, Rv1877 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-C), splits Rv1877 into 2 parts; integral membrane protein 2109704..2110918 Mycobacterium bovis BCG str. Tokyo 172 7560638 YP_002644953.1 CDS glnA3 NC_012207.1 2110973 2112325 D Identical to Rv1878, differs from Mb1910 by 1aa, A275T in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; glutamine synthetase 2110973..2112325 Mycobacterium bovis BCG str. Tokyo 172 7560639 YP_002644954.1 CDS JTY_1900 NC_012207.1 2112328 2113464 D hypothetical protein 2112328..2113464 Mycobacterium bovis BCG str. Tokyo 172 7561928 YP_002644955.1 CDS cyp140 NC_012207.1 2113492 2114808 R cytochrome p450 140 complement(2113492..2114808) Mycobacterium bovis BCG str. Tokyo 172 7560640 YP_002644956.1 CDS lppE NC_012207.1 2114858 2115280 R lipoprotein complement(2114858..2115280) Mycobacterium bovis BCG str. Tokyo 172 7563166 YP_002644957.1 CDS JTY_1903 NC_012207.1 2115321 2116154 R short chain dehydrogenase complement(2115321..2116154) Mycobacterium bovis BCG str. Tokyo 172 7560470 YP_002644958.1 CDS JTY_1904 NC_012207.1 2116182 2116658 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 15 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (158 aa versus 153 aa); hypothetical protein complement(2116182..2116658) Mycobacterium bovis BCG str. Tokyo 172 7560641 YP_002644959.1 CDS rpfC NC_012207.1 2116697 2117227 R resuscitation-promoting factor complement(2116697..2117227) Mycobacterium bovis BCG str. Tokyo 172 7560642 YP_002644960.1 CDS JTY_1906 NC_012207.1 2117239 2117838 R catalyzes the interconversion of chorismate to prephenate; chorismate mutase complement(2117239..2117838) Mycobacterium bovis BCG str. Tokyo 172 7561598 YP_002644961.1 CDS fbpB NC_012207.1 2117856 2118833 R Differs from Rv1886c and Mb1918c by 1aa, L140F; antigen 85-B complement(2117856..2118833) Mycobacterium bovis BCG str. Tokyo 172 7560643 YP_002644962.1 CDS JTY_1908 NC_012207.1 2119224 2120366 D Differs from Rv1887 and Mb1919 by 1aa, C121Y in BCG Pasteur and BCG Tokyo; hypothetical protein 2119224..2120366 Mycobacterium bovis BCG str. Tokyo 172 7563401 YP_002644963.1 CDS JTY_1909 NC_012207.1 2120336 2121055 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 10 bp insertion (*-TCCGATCACC) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv (239 aa versus 186 aa); transmembrane protein complement(2120336..2121055) Mycobacterium bovis BCG str. Tokyo 172 7560644 YP_002644964.1 CDS JTY_1910 NC_012207.1 2121420 2121593 R hypothetical protein complement(2121420..2121593) Mycobacterium bovis BCG str. Tokyo 172 7560645 YP_002644965.1 CDS JTY_1911 NC_012207.1 2121637 2121993 R hypothetical protein complement(2121637..2121993) Mycobacterium bovis BCG str. Tokyo 172 7560646 YP_002644966.1 CDS JTY_1912 NC_012207.1 2122052 2122663 R hypothetical protein complement(2122052..2122663) Mycobacterium bovis BCG str. Tokyo 172 7560647 YP_002644967.1 CDS JTY_1913 NC_012207.1 2122717 2123124 D hypothetical protein 2122717..2123124 Mycobacterium bovis BCG str. Tokyo 172 7560648 YP_002644968.1 CDS JTY_1914 NC_012207.1 2123141 2123452 D hypothetical protein 2123141..2123452 Mycobacterium bovis BCG str. Tokyo 172 7560649 YP_002644969.1 CDS JTY_1915 NC_012207.1 2123462 2123680 D hypothetical protein 2123462..2123680 Mycobacterium bovis BCG str. Tokyo 172 7560650 YP_002644970.1 CDS JTY_1916 NC_012207.1 2123715 2124845 R hypothetical protein complement(2123715..2124845) Mycobacterium bovis BCG str. Tokyo 172 7560651 YP_002644971.1 CDS JTY_1917 NC_012207.1 2125497 2125820 D In Mycobacterium tuberculosis strain H37Rv, Rv1895 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, two frameshifts due to a single base deletion (A-*) and a single base insertion (*-T), consecutively, splits Rv1895 into 2 main parts, Mb1928 and Mb1929; dehydrogenase 2125497..2125820 Mycobacterium bovis BCG str. Tokyo 172 7560652 YP_002644972.1 CDS JTY_1918 NC_012207.1 2125817 2126521 D In Mycobacterium tuberculosis strain H37Rv, Rv1895 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, two frameshifts due to a single base deletion (A-*) and a single base insertion (*-T), consecutively, splits Rv1895 into 2 main parts, Mb1928 and Mb1929; dehydrogenase 2125817..2126521 Mycobacterium bovis BCG str. Tokyo 172 7560653 YP_002644973.1 CDS JTY_1919 NC_012207.1 2126511 2127422 R hypothetical protein complement(2126511..2127422) Mycobacterium bovis BCG str. Tokyo 172 7560654 YP_002644974.1 CDS JTY_1920 NC_012207.1 2127427 2127858 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(2127427..2127858) Mycobacterium bovis BCG str. Tokyo 172 7560655 YP_002644975.1 CDS JTY_1921 NC_012207.1 2127916 2128224 D hypothetical protein 2127916..2128224 Mycobacterium bovis BCG str. Tokyo 172 7560656 YP_002644976.1 CDS lppD NC_012207.1 2128190 2129266 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 45 bp in-frame insertion leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (358 aa versus 343 aa); lipoprotein complement(2128190..2129266) Mycobacterium bovis BCG str. Tokyo 172 7560657 YP_002644977.1 CDS lipJ NC_012207.1 2129266 2130654 R Differs from Rv1900c and Mb1935c by 1aa, M204I and R170Q, respectively, in BCG Pasteur and BCG Tokyo; lignin peroxidase complement(2129266..2130654) Mycobacterium bovis BCG str. Tokyo 172 7560469 YP_002644978.1 CDS cinA NC_012207.1 2130683 2131975 D competence damage-inducible protein A 2130683..2131975 Mycobacterium bovis BCG str. Tokyo 172 7562838 YP_002644979.1 CDS nanT NC_012207.1 2132027 2133295 R sialic acid-transport integral membrane protein complement(2132027..2133295) Mycobacterium bovis BCG str. Tokyo 172 7562104 YP_002644980.1 CDS JTY_1926 NC_012207.1 2133385 2133789 D hypothetical protein 2133385..2133789 Mycobacterium bovis BCG str. Tokyo 172 7563592 YP_002644981.1 CDS JTY_1927 NC_012207.1 2133975 2134406 D Differs from Rv1904 by 1aa, M130T in BCG Pasteur and BCG Tokyo; hypothetical protein 2133975..2134406 Mycobacterium bovis BCG str. Tokyo 172 7560658 YP_002644982.1 CDS aao NC_012207.1 2134454 2135416 R Differs from Rv1905c by 1aa, T240P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; D-amino acid oxidase complement(2134454..2135416) Mycobacterium bovis BCG str. Tokyo 172 7560659 YP_002644983.1 CDS JTY_1929 NC_012207.1 2135446 2135916 R hypothetical protein complement(2135446..2135916) Mycobacterium bovis BCG str. Tokyo 172 7564328 YP_002644984.1 CDS JTY_1930 NC_012207.1 2136256 2136903 R hypothetical protein complement(2136256..2136903) Mycobacterium bovis BCG str. Tokyo 172 7560660 YP_002644985.1 CDS katG NC_012207.1 2136910 2139132 R Differs from Rv1908c by 1aa, L463R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; catalase-peroxidase-peroxynitritase T complement(2136910..2139132) Mycobacterium bovis BCG str. Tokyo 172 7560661 YP_002644986.1 CDS furA NC_012207.1 2139170 2139622 R Differs from Rv1909c and Mb1944c by 1aa, V46A in BCG Pasteur and BCG Tokyo; ferric uptake regulation protein complement(2139170..2139622) Mycobacterium bovis BCG str. Tokyo 172 7562800 YP_002644987.1 CDS JTY_1933 NC_012207.1 2139727 2140320 R hypothetical protein complement(2139727..2140320) Mycobacterium bovis BCG str. Tokyo 172 7561886 YP_002644988.1 CDS lppC NC_012207.1 2140403 2141008 R lipoprotein complement(2140403..2141008) Mycobacterium bovis BCG str. Tokyo 172 7560662 YP_002644989.1 CDS fadB5 NC_012207.1 2141108 2142112 R Differs from Rv1912c by 1aa, G328D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase complement(2141108..2142112) Mycobacterium bovis BCG str. Tokyo 172 7560468 YP_002644990.1 CDS JTY_1936 NC_012207.1 2142212 2142964 D Differs from Rv1913 and Mb1948 by 1aa, C7R in BCG Pasteur and BCG Tokyo; hypothetical protein 2142212..2142964 Mycobacterium bovis BCG str. Tokyo 172 7562914 YP_002644991.1 CDS JTY_1937 NC_012207.1 2142942 2143349 R hypothetical protein complement(2142942..2143349) Mycobacterium bovis BCG str. Tokyo 172 7560663 YP_002644992.1 CDS aceA NC_012207.1 2143484 2145784 D In Mycobacterium tuberculosis strain H37Rv, aceAa and aceAb exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base insertion (*-T) leads to a single product; isocitrate lyase 2143484..2145784 Mycobacterium bovis BCG str. Tokyo 172 7560664 YP_002644993.1 CDS PPE34 NC_012207.1 2145954 2151461 R Equivalent to Mb1951c and Rv1917c but differs by several in-frame insertion and deletion events. Differs from Mb1951c by 69 bp insertion, 69 bp deletion and 225 bp deletion. Differs from Rv1917c by deletions of 12 and 138 bp, insertions of 552 and 150 bp, and substitution of 52bp by 628 bp in BCG Pasteur and BCG Tokyo; PPE family protein complement(2145954..2151461) Mycobacterium bovis BCG str. Tokyo 172 7563927 YP_002644994.1 CDS PPE35a NC_012207.1 2152886 2154763 R In Mycobacterium tuberculosis strain H37Rv, PPE35 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-T) splits PPE35 into 2 parts, PPE35a and PPE35b. Differs from Mb1953c by 1aa, F565V in Mycobacterium bovis BCG Pasteur and BCG Tokyo.; PPE family protein complement(2152886..2154763) Mycobacterium bovis BCG str. Tokyo 172 7562175 YP_002644995.1 CDS JTY_1942 NC_012207.1 2155212 2155676 R hypothetical protein complement(2155212..2155676) Mycobacterium bovis BCG str. Tokyo 172 7562174 YP_002644996.1 CDS JTY_1943 NC_012207.1 2155774 2156637 D Differs from Rv1920 by 1aa, I130M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2155774..2156637 Mycobacterium bovis BCG str. Tokyo 172 7560665 YP_002644997.1 CDS lppF NC_012207.1 2156675 2157946 R lipoprotein complement(2156675..2157946) Mycobacterium bovis BCG str. Tokyo 172 7560666 YP_002644998.1 CDS JTY_1945 NC_012207.1 2158218 2159333 D lipoprotein 2158218..2159333 Mycobacterium bovis BCG str. Tokyo 172 7560471 YP_002644999.1 CDS lipD NC_012207.1 2159324 2160664 D Differs from Rv1923 by 2aa, D73G, N181D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteyr, and BCG Tokyo; lipase 2159324..2160664 Mycobacterium bovis BCG str. Tokyo 172 7560667 YP_002645000.1 CDS JTY_1947 NC_012207.1 2160701 2161081 R hypothetical protein complement(2160701..2161081) Mycobacterium bovis BCG str. Tokyo 172 7562832 YP_002645001.1 CDS fadD31 NC_012207.1 2161238 2163100 D activates fatty acids by binding to coenzyme A; fatty-acid--CoA ligase 2161238..2163100 Mycobacterium bovis BCG str. Tokyo 172 7560668 YP_002645002.1 CDS mpt63 NC_012207.1 2163108 2163587 R hypothetical protein complement(2163108..2163587) Mycobacterium bovis BCG str. Tokyo 172 7562937 YP_002645003.1 CDS JTY_1950 NC_012207.1 2163824 2164597 D hypothetical protein 2163824..2164597 Mycobacterium bovis BCG str. Tokyo 172 7563555 YP_002645004.1 CDS JTY_1951 NC_012207.1 2164601 2165368 R short chain dehydrogenase complement(2164601..2165368) Mycobacterium bovis BCG str. Tokyo 172 7560669 YP_002645005.1 CDS JTY_1952 NC_012207.1 2165413 2166057 R hypothetical protein complement(2165413..2166057) Mycobacterium bovis BCG str. Tokyo 172 7560670 YP_002645006.1 CDS JTY_1953 NC_012207.1 2166069 2166593 R hypothetical protein complement(2166069..2166593) Mycobacterium bovis BCG str. Tokyo 172 7560671 YP_002645007.1 CDS JTY_1954 NC_012207.1 2166611 2167390 R transcriptional regulatory protein complement(2166611..2167390) Mycobacterium bovis BCG str. Tokyo 172 7560672 YP_002645008.1 CDS tpx NC_012207.1 2167523 2168020 D antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 2167523..2168020 Mycobacterium bovis BCG str. Tokyo 172 7560673 YP_002645009.1 CDS fadE18 NC_012207.1 2168017 2169108 R acyl-CoA dehydrogenase complement(2168017..2169108) Mycobacterium bovis BCG str. Tokyo 172 7561865 YP_002645010.1 CDS fadE17 NC_012207.1 2169110 2170339 R acyl-CoA dehydrogenase complement(2169110..2170339) Mycobacterium bovis BCG str. Tokyo 172 7563366 YP_002645011.1 CDS echA13 NC_012207.1 2170354 2171310 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(2170354..2171310) Mycobacterium bovis BCG str. Tokyo 172 7563365 YP_002645012.1 CDS JTY_1959 NC_012207.1 2171535 2172644 D monooxygenase 2171535..2172644 Mycobacterium bovis BCG str. Tokyo 172 7561525 YP_002645013.1 CDS JTY_1960 NC_012207.1 2172647 2175166 D oxygenase 2172647..2175166 Mycobacterium bovis BCG str. Tokyo 172 7560674 YP_002645014.1 CDS ephB NC_012207.1 2175178 2176248 D epoxide hydrolase 2175178..2176248 Mycobacterium bovis BCG str. Tokyo 172 7560675 YP_002645015.1 CDS JTY_1962 NC_012207.1 2176245 2176760 D In Mycobacterium bovis, a single base deletion (T-*) leads to a longer product with a different COOH part compared to its homologs in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (244 aa versus 171 aa); oxidoreductase 2176245..2176760 Mycobacterium bovis BCG str. Tokyo 172 7562867 YP_002645016.1 CDS ribA1 NC_012207.1 2176757 2177818 D GTP cyclohydrolase II; riboflavin biosynthesis protein 2176757..2177818 Mycobacterium bovis BCG str. Tokyo 172 7560676 YP_002645017.1 CDS JTY_1964 NC_012207.1 2177815 2178585 D short-chain type dehydrogenase/reductase 2177815..2178585 Mycobacterium bovis BCG str. Tokyo 172 7561571 YP_002645018.1 CDS JTY_1965 NC_012207.1 2178795 2179124 R hypothetical protein complement(2178795..2179124) Mycobacterium bovis BCG str. Tokyo 172 7560677 YP_002645019.1 CDS JTY_1966 NC_012207.1 2179121 2179498 R hypothetical protein complement(2179121..2179498) Mycobacterium bovis BCG str. Tokyo 172 7560678 YP_002645020.1 CDS JTY_1967 NC_012207.1 2179495 2180085 R Differs from Rv1944c and Mb1979c by 2aa, E4D, A5T, due to 2 bp substitution ta-cc in BCG Pasteur and BCG Tokyo; hypothetical protein complement(2179495..2180085) Mycobacterium bovis BCG str. Tokyo 172 7560679 YP_002645021.1 CDS JTY_1968 NC_012207.1 2180140 2181504 D Differs from Mb1980 and Rv1945 by substitutions of 44, 29, 2, 10 and 34 bp, or 44, 29, 4, 2, 10 and 34 bp, respectively. Corresponding to 10 aa from Rv1945, L242V, N264H, A267G, F268L, A271G, K285R, I291V, N328H, H417K and P426A, and to 9 aa from Mb1980, N264H, A267G, F268L, A271G, K285R, I291V, N328H, H417K and P426A in BCG Pasteur and BCG Tokyo; hypothetical protein 2180140..2181504 Mycobacterium bovis BCG str. Tokyo 172 7564322 YP_002645022.1 CDS lppG NC_012207.1 2181659 2182111 R Differs from Rv1946c by 1aa, T98A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein complement(2181659..2182111) Mycobacterium bovis BCG str. Tokyo 172 7560680 YP_002645023.1 CDS JTY_1970 NC_012207.1 2182175 2182576 D hypothetical protein 2182175..2182576 Mycobacterium bovis BCG str. Tokyo 172 7560472 YP_002645024.1 CDS JTY_1971 NC_012207.1 2182865 2183215 R Differs from Rv1948c by 1aa, R5G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2182865..2183215) Mycobacterium bovis BCG str. Tokyo 172 7560681 YP_002645025.1 CDS JTY_1972 NC_012207.1 2183226 2184128 R Differs from Rv1949c by 1aa, L188F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2183226..2184128) Mycobacterium bovis BCG str. Tokyo 172 7560682 YP_002645026.1 CDS JTY_1973 NC_012207.1 2184149 2184340 R hypothetical protein complement(2184149..2184340) Mycobacterium bovis BCG str. Tokyo 172 7560683 YP_002645027.1 CDS JTY_1974 NC_012207.1 2184341 2184637 R hypothetical protein complement(2184341..2184637) Mycobacterium bovis BCG str. Tokyo 172 7560684 YP_002645028.1 CDS JTY_1975 NC_012207.1 2184877 2185092 D hypothetical protein 2184877..2185092 Mycobacterium bovis BCG str. Tokyo 172 7560685 YP_002645029.1 CDS JTY_1976 NC_012207.1 2185089 2185400 D hypothetical protein 2185089..2185400 Mycobacterium bovis BCG str. Tokyo 172 7560686 YP_002645030.1 CDS JTY_1977 NC_012207.1 2185374 2185895 R Differs from Rv1954c by 1aa, R150H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2185374..2185895) Mycobacterium bovis BCG str. Tokyo 172 7560687 YP_002645031.1 CDS JTY_1978 NC_012207.1 2185735 2186247 D hypothetical protein 2185735..2186247 Mycobacterium bovis BCG str. Tokyo 172 7560688 YP_002645032.1 CDS JTY_1979 NC_012207.1 2186289 2186738 D transcriptional regulatory protein 2186289..2186738 Mycobacterium bovis BCG str. Tokyo 172 7560689 YP_002645033.1 CDS JTY_1980 NC_012207.1 2186735 2187280 D hypothetical protein 2186735..2187280 Mycobacterium bovis BCG str. Tokyo 172 7560690 YP_002645034.1 CDS JTY_1981 NC_012207.1 2187169 2187783 R hypothetical protein complement(2187169..2187783) Mycobacterium bovis BCG str. Tokyo 172 7560691 YP_002645035.1 CDS JTY_1982 NC_012207.1 2187832 2188128 R hypothetical protein complement(2187832..2188128) Mycobacterium bovis BCG str. Tokyo 172 7560692 YP_002645036.1 CDS JTY_1983 NC_012207.1 2188125 2188376 R hypothetical protein complement(2188125..2188376) Mycobacterium bovis BCG str. Tokyo 172 7560693 YP_002645037.1 CDS JTY_1984 NC_012207.1 2188363 2188857 D hypothetical protein 2188363..2188857 Mycobacterium bovis BCG str. Tokyo 172 7560694 YP_002645038.1 CDS JTY_1985 NC_012207.1 2189017 2189424 R hypothetical protein complement(2189017..2189424) Mycobacterium bovis BCG str. Tokyo 172 7560695 YP_002645039.1 CDS JTY_1986 NC_012207.1 2189428 2189700 R antitoxin complement(2189428..2189700) Mycobacterium bovis BCG str. Tokyo 172 7560696 YP_002645040.1 CDS JTY_1987 NC_012207.1 2189733 2190953 R transcriptional regulatory protein complement(2189733..2190953) Mycobacterium bovis BCG str. Tokyo 172 7560697 YP_002645041.1 CDS yrbE3A NC_012207.1 2191852 2192256 D In Mycobacterium bovis Mycobacterium bovis BCG Pasteur and BCG Tokyo, a large deletion of 12719 bp (RD7) leads to the loss of the COOH part of Rv1964|yrbE3A, the entire mce3 operon and the following genes up to Rv1978, compared to Mycobacterium tuberculosis strain H37Rv. Follow by a second deletion of 10287bp, RD2 region (only in Mycobacterium bovis BCG Pasteur), which removes genes Rv1979c-Rv1787 and merges truncated part of Rv1978 and Rv1988 compared to Mycobacterium tuberculosis strain H37Rv; hypothetical protein 2191852..2192256 Mycobacterium bovis BCG str. Tokyo 172 7560698 YP_002645042.1 CDS JTY_1989 NC_012207.1 2192341 2193189 D hypothetical protein 2192341..2193189 Mycobacterium bovis BCG str. Tokyo 172 7561454 YP_002645043.1 CDS JTY_1990 NC_012207.1 2193152 2194597 R Differ from Rv1979c by 2aa, G286D, I457V in Mycobacterium bovis and Mycobacterium bovis BCG Tokyo.; permease complement(2193152..2194597) Mycobacterium bovis BCG str. Tokyo 172 7560699 YP_002645044.1 CDS mpt64 NC_012207.1 2194776 2195462 R Equivalent to Mycobacterium bovis (Mb2002c) and Mycobacterium tuberculosis H37Rv (Rv1980c) in Mycobacterium bovis BCG Tokyo.; antigen MPT64/MPB64; hypothetical protein complement(2194776..2195462) Mycobacterium bovis BCG str. Tokyo 172 7560700 YP_002645045.1 CDS nrdF1 NC_012207.1 2195653 2196621 R Differ from Rv1981c by 1aa, R5L in Mycobacterium bovis and Mycobacterium bovis BCG Tokyo.; ribonucleotide-diphosphate reductase subunit beta complement(2195653..2196621) Mycobacterium bovis BCG str. Tokyo 172 7563556 YP_002645046.1 CDS JTY_1993 NC_012207.1 2196846 2197265 R Equivalent to Mycobacterium bovis (Mb2004c) and Mycobacterium tuberculosis H37Rv (Rv1982c) in Mycobacterium bovis BCG Tokyo; hypothetical protein complement(2196846..2197265) Mycobacterium bovis BCG str. Tokyo 172 7562466 YP_002645047.1 CDS PE_PGRS35 NC_012207.1 2197677 2199353 D Differ from Rv1983 by 1aa, T220A in Mycobacterium bovis and Mycobacterium bovis BCG Tokyo.; PE-PGRS family protein 2197677..2199353 Mycobacterium bovis BCG str. Tokyo 172 7560701 YP_002645048.1 CDS cfp21 NC_012207.1 2199341 2199994 R Equivalent to Mycobacterium bovis (Mb2006c) and Mycobacterium tuberculosis H37Rv (Rv1984c) in Mycobacterium bovis BCG Tokyo; cutinase precursor complement(2199341..2199994) Mycobacterium bovis BCG str. Tokyo 172 7561779 YP_002645049.1 CDS JTY_1996 NC_012207.1 2200424 2201335 R specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein complement(2200424..2201335) Mycobacterium bovis BCG str. Tokyo 172 7562099 YP_002645050.1 CDS JTY_1997 NC_012207.1 2201444 2202043 D Equivalent to Mycobacterium bovis (Mb2008) and Mycobacterium tuberculosis H37Rv (Rv1986) in Mycobacterium bovis BCG Tokyo; hypothetical protein 2201444..2202043 Mycobacterium bovis BCG str. Tokyo 172 7560702 YP_002645051.1 CDS JTY_1998 NC_012207.1 2202459 2202887 D Equivalent to Mycobacterium bovis (Mb2009) and Mycobacterium tuberculosis H37Rv (Rv1987) in Mycobacterium bovis BCG Tokyo; chitinase 2202459..2202887 Mycobacterium bovis BCG str. Tokyo 172 7560703 YP_002645052.1 CDS JTY_1999 NC_012207.1 2203113 2203652 D Equivalent to Mycobacterium bovis (Mb2010) and Mycobacterium tuberculosis H37Rv (Rv1988)in Mycobacterium bovis BCG Tokyo; methyltransferase 2203113..2203652 Mycobacterium bovis BCG str. Tokyo 172 7560704 YP_002645053.1 CDS JTY_2000 NC_012207.1 2204172 2204732 R hypothetical protein complement(2204172..2204732) Mycobacterium bovis BCG str. Tokyo 172 7560705 YP_002645054.1 CDS JTY_2001 NC_012207.1 2204729 2205070 R transcriptional regulatory protein complement(2204729..2205070) Mycobacterium bovis BCG str. Tokyo 172 7560706 YP_002645055.1 CDS JTY_2002 NC_012207.1 2205314 2205649 R dehydrogenase complement(2205314..2205649) Mycobacterium bovis BCG str. Tokyo 172 7560707 YP_002645056.1 CDS JTY_2003 NC_012207.1 2205738 2206082 R hypothetical protein complement(2205738..2206082) Mycobacterium bovis BCG str. Tokyo 172 7560708 YP_002645057.1 CDS ctpG NC_012207.1 2206424 2208739 R metal cation transporter P-type ATPase G complement(2206424..2208739) Mycobacterium bovis BCG str. Tokyo 172 7560709 YP_002645058.1 CDS JTY_2005 NC_012207.1 2208736 2209008 R hypothetical protein complement(2208736..2209008) Mycobacterium bovis BCG str. Tokyo 172 7563137 YP_002645059.1 CDS JTY_2006 NC_012207.1 2209061 2209417 R transcriptional regulatory protein complement(2209061..2209417) Mycobacterium bovis BCG str. Tokyo 172 7560710 YP_002645060.1 CDS JTY_2007 NC_012207.1 2209574 2210341 D hypothetical protein 2209574..2210341 Mycobacterium bovis BCG str. Tokyo 172 7560711 YP_002645061.1 CDS JTY_2008 NC_012207.1 2210437 2211390 D hypothetical protein 2210437..2211390 Mycobacterium bovis BCG str. Tokyo 172 7561204 YP_002645062.1 CDS ctpF NC_012207.1 2211592 2214309 D Differs from Rv1997 and Mb2020 by 1aa, D138E in BCG Pasteur and BCG Tokyo; metal cation transporter P-type ATPase A 2211592..2214309 Mycobacterium bovis BCG str. Tokyo 172 7561205 YP_002645063.1 CDS JTY_2010 NC_012207.1 2214378 2215154 R Differs from Rv1998c by 1aa, R230S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2214378..2215154) Mycobacterium bovis BCG str. Tokyo 172 7563136 YP_002645064.1 CDS JTY_2011 NC_012207.1 2215249 2216571 R integral membrane protein complement(2215249..2216571) Mycobacterium bovis BCG str. Tokyo 172 7561206 YP_002645065.1 CDS JTY_2012 NC_012207.1 2216642 2218255 D hypothetical protein 2216642..2218255 Mycobacterium bovis BCG str. Tokyo 172 7561207 YP_002645066.1 CDS JTY_2013 NC_012207.1 2218265 2219017 D Differs from Rv2001 by 1aa, H113R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2218265..2219017 Mycobacterium bovis BCG str. Tokyo 172 7561208 YP_002645067.1 CDS fabG3 NC_012207.1 2219093 2219875 D 20-beta-hydroxysteroid dehydrogenase 2219093..2219875 Mycobacterium bovis BCG str. Tokyo 172 7561209 YP_002645068.1 CDS JTY_2015 NC_012207.1 2219996 2220853 R hypothetical protein complement(2219996..2220853) Mycobacterium bovis BCG str. Tokyo 172 7562901 YP_002645069.1 CDS JTY_2016 NC_012207.1 2220911 2222407 R hypothetical protein complement(2220911..2222407) Mycobacterium bovis BCG str. Tokyo 172 7561210 YP_002645070.1 CDS JTY_2017 NC_012207.1 2222429 2223316 R hypothetical protein complement(2222429..2223316) Mycobacterium bovis BCG str. Tokyo 172 7561211 YP_002645071.1 CDS otsB1 NC_012207.1 2223435 2227418 D Differs from Rv2006 and Mb2029 by 1aa, S80G and L1245P, respectively, in BCG Pasteur and BCG Tokyo; trehalose-6-phosphate phosphatase 2223435..2227418 Mycobacterium bovis BCG str. Tokyo 172 7561212 YP_002645072.1 CDS fdxA NC_012207.1 2227517 2227861 R ferredoxin complement(2227517..2227861) Mycobacterium bovis BCG str. Tokyo 172 7562503 YP_002645073.1 CDS JTY_2020 NC_012207.1 2228050 2229375 R hypothetical protein complement(2228050..2229375) Mycobacterium bovis BCG str. Tokyo 172 7563406 YP_002645074.1 CDS JTY_2021 NC_012207.1 2229463 2229705 D hypothetical protein 2229463..2229705 Mycobacterium bovis BCG str. Tokyo 172 7561213 YP_002645075.1 CDS JTY_2022 NC_012207.1 2229706 2230104 D hypothetical protein 2229706..2230104 Mycobacterium bovis BCG str. Tokyo 172 7561214 YP_002645076.1 CDS JTY_2023 NC_012207.1 2230287 2230718 R hypothetical protein complement(2230287..2230718) Mycobacterium bovis BCG str. Tokyo 172 7561215 YP_002645077.1 CDS JTY_2024 NC_012207.1 2230759 2231253 D hypothetical protein 2230759..2231253 Mycobacterium bovis BCG str. Tokyo 172 7561216 YP_002645078.1 CDS JTY_2025 NC_012207.1 2231957 2232574 D In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (c-t) at the 5' start, leads to a longer product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (206 aa versus 159 aa); transposase 2231957..2232574 Mycobacterium bovis BCG str. Tokyo 172 7561217 YP_002645079.1 CDS JTY_2026 NC_012207.1 2232528 2233118 D Identical to Mb2037 including extra 5 aa at C-terminus compared to Rv2014 in Mycobacterium bovis BCG Pasteur and BCG Tokyo; transposase 2232528..2233118 Mycobacterium bovis BCG str. Tokyo 172 7561218 YP_002645080.1 CDS JTY_2027 NC_012207.1 2233246 2234502 R Differs from Mb2038c by 1aa S59L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2233246..2234502) Mycobacterium bovis BCG str. Tokyo 172 7561219 YP_002645081.1 CDS JTY_2028 NC_012207.1 2234856 2235431 D hypothetical protein 2234856..2235431 Mycobacterium bovis BCG str. Tokyo 172 7561220 YP_002645082.1 CDS JTY_2029 NC_012207.1 2235428 2236468 D Differs from Rv2017 by 1aa, E262A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical regulatory protein 2235428..2236468 Mycobacterium bovis BCG str. Tokyo 172 7561221 YP_002645083.1 CDS JTY_2030 NC_012207.1 2236710 2237429 D Differs from Rv2018 by 1aa, G116D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2236710..2237429 Mycobacterium bovis BCG str. Tokyo 172 7561222 YP_002645084.1 CDS JTY_2031 NC_012207.1 2237419 2237835 D hypothetical protein 2237419..2237835 Mycobacterium bovis BCG str. Tokyo 172 7561223 YP_002645085.1 CDS JTY_2032 NC_012207.1 2237851 2238150 R hypothetical protein complement(2237851..2238150) Mycobacterium bovis BCG str. Tokyo 172 7561224 YP_002645086.1 CDS JTY_2033 NC_012207.1 2238235 2238540 R hypothetical protein complement(2238235..2238540) Mycobacterium bovis BCG str. Tokyo 172 7561225 YP_002645087.1 CDS JTY_2034 NC_012207.1 2238549 2239154 R hypothetical protein complement(2238549..2239154) Mycobacterium bovis BCG str. Tokyo 172 7561226 YP_002645088.1 CDS JTY_2035 NC_012207.1 2239179 2239538 R hypothetical protein complement(2239179..2239538) Mycobacterium bovis BCG str. Tokyo 172 7561227 YP_002645089.1 CDS JTY_2036 NC_012207.1 2239698 2240375 R Belongs to the RvD1 region. Absent in Mycobacterium tuberculosis strain H37Rv; hypothetical protein complement(2239698..2240375) Mycobacterium bovis BCG str. Tokyo 172 7561228 YP_002645090.1 CDS JTY_2037 NC_012207.1 2240770 2241666 R Belongs to the RvD1 region. Absent in Mycobacterium tuberculosis strain H37Rv. Differs from Mb2048c by 1aa, E139K in Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein complement(2240770..2241666) Mycobacterium bovis BCG str. Tokyo 172 7561229 YP_002645091.1 CDS JTY_2038 NC_012207.1 2241850 2246670 R In Mycobacterium tuberculosis strain H37Rv, a large deletion region (RvD1) exists in between Rv2023 and Rv2024. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 5000 bp insertion at this region results in Mb2049c being a much larger product with a different COOH part (1606 aa versus 515 aa), and in 2 extra genes, Mb2046c and Mb2047c. Differs from N-terminal part of Rv2024c (truncated by RvD1) by 3aa, R47W, G154D, C289R and Mb2049c by 1aa, F341V in BCG Pasteur and BCG Tokyo; hypothetical protein complement(2241850..2246670) Mycobacterium bovis BCG str. Tokyo 172 7561230 YP_002645092.1 CDS JTY_2039 NC_012207.1 2247180 2248178 R hypothetical protein complement(2247180..2248178) Mycobacterium bovis BCG str. Tokyo 172 7561231 YP_002645093.1 CDS JTY_2040 NC_012207.1 2248293 2249177 R hypothetical protein complement(2248293..2249177) Mycobacterium bovis BCG str. Tokyo 172 7561232 YP_002645094.1 CDS JTY_2041 NC_012207.1 2249217 2250938 R Differs from Rv2027c by 1aa, V15L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; histidine kinase response regulator complement(2249217..2250938) Mycobacterium bovis BCG str. Tokyo 172 7561233 YP_002645095.1 CDS JTY_2042 NC_012207.1 2250999 2251838 R hypothetical protein complement(2250999..2251838) Mycobacterium bovis BCG str. Tokyo 172 7561234 YP_002645096.1 CDS pfkB NC_012207.1 2251835 2252854 R phosphofructokinase complement(2251835..2252854) Mycobacterium bovis BCG str. Tokyo 172 7561235 YP_002645097.1 CDS JTY_2044 NC_012207.1 2252871 2254916 R In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, Rv2030c exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (G-*) splits Rv2030c into 2 parts, Mb2055c and Mb2056c; hypothetical protein complement(2252871..2254916) Mycobacterium bovis BCG str. Tokyo 172 7562396 YP_002645098.1 CDS hspX NC_012207.1 2254928 2255362 R heat shock protein complement(2254928..2255362) Mycobacterium bovis BCG str. Tokyo 172 7561236 YP_002645099.1 CDS JTY_2046 NC_012207.1 2255559 2256554 D Differs from Rv2032 by 1aa, L318P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2255559..2256554 Mycobacterium bovis BCG str. Tokyo 172 7563330 YP_002645100.1 CDS JTY_2047 NC_012207.1 2256670 2257512 R hypothetical protein complement(2256670..2257512) Mycobacterium bovis BCG str. Tokyo 172 7561237 YP_002645101.1 CDS JTY_2048 NC_012207.1 2257724 2258047 D ArsR-type repressor protein 2257724..2258047 Mycobacterium bovis BCG str. Tokyo 172 7561238 YP_002645102.1 CDS JTY_2049 NC_012207.1 2258044 2258532 D hypothetical protein 2258044..2258532 Mycobacterium bovis BCG str. Tokyo 172 7561239 YP_002645103.1 CDS JTY_2050 NC_012207.1 2258529 2259170 D Differs from Rv2036 by 1aa, V93A due to 2bp substitution cc-tt in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2258529..2259170 Mycobacterium bovis BCG str. Tokyo 172 7561240 YP_002645104.1 CDS JTY_2051 NC_012207.1 2259177 2260151 R Differs from Rv2037c by 1aa, Y312C in Mycobacterium tuberclosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein complement(2259177..2260151) Mycobacterium bovis BCG str. Tokyo 172 7561241 YP_002645105.1 CDS JTY_2052 NC_012207.1 2260153 2261226 R sugar-transport ATP-binding protein ABC transporter complement(2260153..2261226) Mycobacterium bovis BCG str. Tokyo 172 7561242 YP_002645106.1 CDS JTY_2053 NC_012207.1 2261229 2262071 R Differs from Rv2039c by 1aa, F131V in Mycobacterium tuberclosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; sugar-transport integral membrane protein ABC transporter complement(2261229..2262071) Mycobacterium bovis BCG str. Tokyo 172 7561243 YP_002645107.1 CDS JTY_2054 NC_012207.1 2262058 2262960 R sugar-transport integral membrane protein ABC transporter complement(2262058..2262960) Mycobacterium bovis BCG str. Tokyo 172 7561244 YP_002645108.1 CDS JTY_2055 NC_012207.1 2262957 2264276 R sugar-binding lipoprotein complement(2262957..2264276) Mycobacterium bovis BCG str. Tokyo 172 7561245 YP_002645109.1 CDS JTY_2056 NC_012207.1 2264314 2265111 R hypothetical protein complement(2264314..2265111) Mycobacterium bovis BCG str. Tokyo 172 7561246 YP_002645110.1 CDS pncA NC_012207.1 2265111 2265671 R Differs from Rv2043c by 1aa, D57H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; pyrazinamidase/nicotinamidase complement(2265111..2265671) Mycobacterium bovis BCG str. Tokyo 172 7561247 YP_002645111.1 CDS JTY_2058 NC_012207.1 2265712 2266029 R hypothetical protein complement(2265712..2266029) Mycobacterium bovis BCG str. Tokyo 172 7562134 YP_002645112.1 CDS lipT NC_012207.1 2266115 2267650 R carboxylesterase complement(2266115..2267650) Mycobacterium bovis BCG str. Tokyo 172 7561248 YP_002645113.1 CDS lppI NC_012207.1 2267699 2268355 D Differs from Rv2046 by 1aa, P17S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 2267699..2268355 Mycobacterium bovis BCG str. Tokyo 172 7562846 YP_002645114.1 CDS JTY_2061 NC_012207.1 2268392 2270956 R hypothetical protein complement(2268392..2270956) Mycobacterium bovis BCG str. Tokyo 172 7560474 YP_002645115.1 CDS pks12 NC_012207.1 2270961 2283416 R Differs from Mb2074c and Rv2048c in several positions due to various substitutions, transitions and transversions in BCG Pasteur and BCG Tokyo; polyketide synthase complement(2270961..2283416) Mycobacterium bovis BCG str. Tokyo 172 7561249 YP_002645116.1 CDS JTY_2063 NC_012207.1 2283723 2283947 R hypothetical protein complement(2283723..2283947) Mycobacterium bovis BCG str. Tokyo 172 7562443 YP_002645117.1 CDS JTY_2064 NC_012207.1 2284251 2284586 D hypothetical protein 2284251..2284586 Mycobacterium bovis BCG str. Tokyo 172 7561250 YP_002645118.1 CDS ppm1 NC_012207.1 2284561 2287185 R polyprenol-monophosphomannose synthase complement(2284561..2287185) Mycobacterium bovis BCG str. Tokyo 172 7561251 YP_002645119.1 CDS JTY_2066 NC_012207.1 2287343 2288947 R hypothetical protein complement(2287343..2288947) Mycobacterium bovis BCG str. Tokyo 172 7560809 YP_002645120.1 CDS fxsA NC_012207.1 2288952 2289479 R F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA complement(2288952..2289479) Mycobacterium bovis BCG str. Tokyo 172 7561252 YP_002645121.1 CDS JTY_2068 NC_012207.1 2289555 2290268 D hypothetical protein 2289555..2290268 Mycobacterium bovis BCG str. Tokyo 172 7561890 YP_002645122.1 CDS rpsR2 NC_012207.1 2290517 2290783 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(2290517..2290783) Mycobacterium bovis BCG str. Tokyo 172 7561253 YP_002645123.1 CDS rpsN NC_012207.1 2290784 2291089 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 complement(2290784..2291089) Mycobacterium bovis BCG str. Tokyo 172 7560747 YP_002645124.1 CDS rpmG NC_012207.1 2291091 2291255 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(2291091..2291255) Mycobacterium bovis BCG str. Tokyo 172 7560742 YP_002645125.1 CDS rpmB NC_012207.1 2291255 2291491 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(2291255..2291491) Mycobacterium bovis BCG str. Tokyo 172 7560720 YP_002645126.1 CDS JTY_2073 NC_012207.1 2291604 2293139 D hypothetical protein 2291604..2293139 Mycobacterium bovis BCG str. Tokyo 172 7560715 YP_002645127.1 CDS JTY_2074 NC_012207.1 2293111 2293515 R hypothetical protein complement(2293111..2293515) Mycobacterium bovis BCG str. Tokyo 172 7561254 YP_002645128.1 CDS cobN NC_012207.1 2293599 2297183 R with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism; cobaltochelatase subunit CobN complement(2293599..2297183) Mycobacterium bovis BCG str. Tokyo 172 7561255 YP_002645129.1 CDS JTY_2076 NC_012207.1 2297261 2297494 D hypothetical protein 2297261..2297494 Mycobacterium bovis BCG str. Tokyo 172 7563113 YP_002645130.1 CDS cobG NC_012207.1 2297881 2298972 D cobalamin biosynthesis protein 2297881..2298972 Mycobacterium bovis BCG str. Tokyo 172 7561256 YP_002645131.1 CDS cobH NC_012207.1 2298982 2299608 D catalyzes the interconversion of precorrin-8X and hydrogenobyrinate; precorrin-8X methylmutase 2298982..2299608 Mycobacterium bovis BCG str. Tokyo 172 7563106 YP_002645132.1 CDS cobI NC_012207.1 2299605 2301131 D S-adenosyl-L-methionine-precorrin-2 methyl transferase, precorrin-3 methylase; CobI-CobJ fusion protein 2299605..2301131 Mycobacterium bovis BCG str. Tokyo 172 7563107 YP_002645133.1 CDS JTY_2080 NC_012207.1 2301077 2302300 R hypothetical protein complement(2301077..2302300) Mycobacterium bovis BCG str. Tokyo 172 7563108 YP_002645134.1 CDS blaC NC_012207.1 2302316 2303239 R class A beta-lactamase complement(2302316..2303239) Mycobacterium bovis BCG str. Tokyo 172 7561257 YP_002645135.1 CDS sigC NC_012207.1 2303374 2303931 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigC 2303374..2303931 Mycobacterium bovis BCG str. Tokyo 172 7562073 YP_002645136.1 CDS cobK NC_012207.1 2303921 2304616 R CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; cobalt-precorrin-6x reductase complement(2303921..2304616) Mycobacterium bovis BCG str. Tokyo 172 7560791 YP_002645137.1 CDS cobM NC_012207.1 2304653 2305408 R Differs from Rv2071c by 1aa, M145I in BCG Pasteur and BCG Tokyo; precorrin-4 C11-methyltransferase complement(2304653..2305408) Mycobacterium bovis BCG str. Tokyo 172 7563109 YP_002645138.1 CDS cobLb NC_012207.1 2305405 2306289 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 2029 bp deletion (H37Rv.2330073-2332101-*)(RD9) leads to the loss of the NH2 part of cobL, the entire Rv2073 and Rv2074, and the COOH part of Mb2100c. In addition, while cobL exists as a single gene in Mycobacterium tuberculosis strain H37Rv, in Mycobacterium bovis a frameshift due to a single base insertion (*-T) splits cobL into 2 parts, cobLa and cobLb; precorrin-6y methyltransferase complement(2305405..2306289) Mycobacterium bovis BCG str. Tokyo 172 7563112 YP_002645139.1 CDS cobLa NC_012207.1 2306231 2306419 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 2029 bp deletion (H37Rv.2330073-2332101-*)(RD9) leads to the loss of the NH2 part of cobL, the entire Rv2073 and Rv2074, and the COOH part of Mb2100c. In addition, while cobL exists as a single gene in Mycobacterium tuberculosis strain H37Rv, in Mycobacterium bovis a frameshift due to a single base insertion (*-T) splits cobL into 2 parts, cobLa and cobLb; precorrin-6y methyltransferase complement(2306231..2306419) Mycobacterium bovis BCG str. Tokyo 172 7563111 YP_002645140.1 CDS JTY_2087 NC_012207.1 2306494 2307282 R In Mycobacterium bovis AF2122/97, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 2029 bp deletion(RD9) leads to the loss of the COOH part of Mb2100c, the entire Rv2074 and Rv2073, and the NH2 part of cobL compared to its homolog in Mycobacterium tuberculosis strain H37Rv; hypothetical protein complement(2306494..2307282) Mycobacterium bovis BCG str. Tokyo 172 7563110 YP_002645141.1 CDS JTY_2088 NC_012207.1 2307440 2307691 R hypothetical protein complement(2307440..2307691) Mycobacterium bovis BCG str. Tokyo 172 7561258 YP_002645142.1 CDS JTY_2089 NC_012207.1 2307726 2308697 R transmembrane protein complement(2307726..2308697) Mycobacterium bovis BCG str. Tokyo 172 7561259 YP_002645143.1 CDS JTY_2090 NC_012207.1 2308698 2308997 R hypothetical protein complement(2308698..2308997) Mycobacterium bovis BCG str. Tokyo 172 7561260 YP_002645144.1 CDS JTY_2091 NC_012207.1 2309462 2309776 D Differs from Rv2078 by 1aa, G6E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2309462..2309776 Mycobacterium bovis BCG str. Tokyo 172 7561261 YP_002645145.1 CDS JTY_2092 NC_012207.1 2309758 2311728 D Differs from Rv2079 by 2aa, C47Y, L216P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2309758..2311728 Mycobacterium bovis BCG str. Tokyo 172 7561262 YP_002645146.1 CDS lppJ NC_012207.1 2311709 2312272 D Differs from Rv2080 by 1aa, A23V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 2311709..2312272 Mycobacterium bovis BCG str. Tokyo 172 7561263 YP_002645147.1 CDS JTY_2094 NC_012207.1 2312468 2312914 R In Mycobacterium bovis BCG Tokyo, insertion 5bp or 2bp compared to its homologs in Mycobacterium tuberculosis strain H37Rv or Mycobacterium bovis leads to a product with different C-terminal part. 5bp:GGGGG insertion in BCG Tokyo after 311:G of Mycobacterium bovis or Mycobacterium tuberculosis H37Rv(Rv2081c), 11bp:GGGGGGGGGGG insertion in BCG Pasteur after 311:G of Mycobacterium tuberculosis H37Rv. In Mycobacterium bovis, a 3 bp in-frame insertion (*-GGG) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (147 aa versus 146 aa).; transmembrane protein complement(2312468..2312914) Mycobacterium bovis BCG str. Tokyo 172 7560475 YP_002645148.1 CDS JTY_2095 NC_012207.1 2313118 2315205 D Differs from Mb2108 (721 aa) and from Rv2082 (721aa) by 26 codon in-frame deletion and from Rv2082 by 2aa, A183T, R612L in BCG Pasteur and BCG Tokyo; hypothetical protein 2313118..2315205 Mycobacterium bovis BCG str. Tokyo 172 7561264 YP_002645149.1 CDS JTY_2096 NC_012207.1 2315202 2316146 D Differs from Rv2083 by 1aa, V256L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2315202..2316146 Mycobacterium bovis BCG str. Tokyo 172 7561265 YP_002645150.1 CDS JTY_2097 NC_012207.1 2316139 2317134 D In Mycobacterium tuberculosis strain H37Rv, Rv2084 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo, a frameshift due to an 11bp insertion (*-GGCGTACACAC), splits Rv2084 into 2 parts; hypothetical protein 2316139..2317134 Mycobacterium bovis BCG str. Tokyo 172 7561266 YP_002645151.1 CDS JTY_2099 NC_012207.1 2317369 2317674 D hypothetical protein 2317369..2317674 Mycobacterium bovis BCG str. Tokyo 172 7561268 YP_002645152.1 CDS JTY_2100 NC_012207.1 2317653 2318258 D hypothetical protein 2317653..2318258 Mycobacterium bovis BCG str. Tokyo 172 7561269 YP_002645153.1 CDS JTY_2101 NC_012207.1 2318336 2318566 D hypothetical protein 2318336..2318566 Mycobacterium bovis BCG str. Tokyo 172 7561270 YP_002645154.1 CDS pknJ NC_012207.1 2318753 2320522 D transmembrane serine/threonine-protein kinase J 2318753..2320522 Mycobacterium bovis BCG str. Tokyo 172 7561271 YP_002645155.1 CDS pepE NC_012207.1 2320539 2321666 R dipeptidase complement(2320539..2321666) Mycobacterium bovis BCG str. Tokyo 172 7562437 YP_002645156.1 CDS JTY_2104 NC_012207.1 2321715 2322782 D In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 114 bp in-frame deletion leads to a shorter product compared to its ortholog in Mycobacterium tuberculosis strain H37Rv (355 aa versus 393 aa) and a 57 bp in-frame deletion leads to a shorter product compared to its ortholog in Mycobacterium bovis (355 aa versus 374 aa). Difference is due to copy number of tandem motif: DPTSGDPLHPAPPRLRSPL (or variant there of) near N-terminus. Also differs from Rv2090 by 1aa, L320F in BCG Pasteur and BCG Tokyo; 5'-3' exonuclease 2321715..2322782 Mycobacterium bovis BCG str. Tokyo 172 7561744 YP_002645157.1 CDS JTY_2105 NC_012207.1 2322786 2323520 R hypothetical protein complement(2322786..2323520) Mycobacterium bovis BCG str. Tokyo 172 7561272 YP_002645158.1 CDS helY NC_012207.1 2323562 2326282 R Differs from Rv2092c by 1aa, M178T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; ATP-dependent DNA helicase complement(2323562..2326282) Mycobacterium bovis BCG str. Tokyo 172 7561273 YP_002645159.1 CDS tatC NC_012207.1 2326331 2327257 R sec-independent protein translocase transmembrane protein complement(2326331..2327257) Mycobacterium bovis BCG str. Tokyo 172 7563295 YP_002645160.1 CDS tatA NC_012207.1 2327274 2327525 R TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A complement(2327274..2327525) Mycobacterium bovis BCG str. Tokyo 172 7561825 YP_002645161.1 CDS JTY_2109 NC_012207.1 2327593 2328543 R Differs from Mb2122c by 1aa, A267V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2327593..2328543) Mycobacterium bovis BCG str. Tokyo 172 7561823 YP_002645162.1 CDS JTY_2110 NC_012207.1 2328540 2329538 R hypothetical protein complement(2328540..2329538) Mycobacterium bovis BCG str. Tokyo 172 7561274 YP_002645163.1 CDS JTY_2111 NC_012207.1 2329547 2330905 R hypothetical protein complement(2329547..2330905) Mycobacterium bovis BCG str. Tokyo 172 7561275 YP_002645164.1 CDS PE_PGRS36 NC_012207.1 2330957 2332432 R In Mycobacterium tuberculosis strain H37Rv, PE_PGRS36 and PE21 exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base insertion (*-c) leads to a single product more similar to PE_PGRS36. There is also a 3 bp in-frame deletion (GGC-*); PE-PGRS family protein complement(2330957..2332432) Mycobacterium bovis BCG str. Tokyo 172 7561276 YP_002645165.1 CDS JTY_2113 NC_012207.1 2332615 2334267 D hypothetical protein 2332615..2334267 Mycobacterium bovis BCG str. Tokyo 172 7561780 YP_002645166.1 CDS helZ NC_012207.1 2334466 2337507 D Differs from Rv2101 by 3aa, L462M, Q601P, S652A in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; helicase 2334466..2337507 Mycobacterium bovis BCG str. Tokyo 172 7561277 YP_002645167.1 CDS JTY_2115 NC_012207.1 2337617 2338333 D hypothetical protein 2337617..2338333 Mycobacterium bovis BCG str. Tokyo 172 7563296 YP_002645168.1 CDS JTY_2116 NC_012207.1 2338312 2338746 R hypothetical protein complement(2338312..2338746) Mycobacterium bovis BCG str. Tokyo 172 7561278 YP_002645169.1 CDS JTY_2117 NC_012207.1 2338753 2339007 R hypothetical protein complement(2338753..2339007) Mycobacterium bovis BCG str. Tokyo 172 7561279 YP_002645170.1 CDS PE22 NC_012207.1 2340227 2340523 D PE family protein 2340227..2340523 Mycobacterium bovis BCG str. Tokyo 172 7561280 YP_002645171.1 CDS PPE36 NC_012207.1 2340579 2341310 D PPE family protein 2340579..2341310 Mycobacterium bovis BCG str. Tokyo 172 7561722 YP_002645172.1 CDS prcA NC_012207.1 2341850 2342596 R Differs from Rv2109c by 2aa, P135R, G182R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; proteasome subunit alpha complement(2341850..2342596) Mycobacterium bovis BCG str. Tokyo 172 7562176 YP_002645173.1 CDS prcB NC_012207.1 2342593 2343468 R proteasome subunit beta complement(2342593..2343468) Mycobacterium bovis BCG str. Tokyo 172 7560819 YP_002645174.1 CDS JTY_2122 NC_012207.1 2343465 2343659 R hypothetical protein complement(2343465..2343659) Mycobacterium bovis BCG str. Tokyo 172 7560820 YP_002645175.1 CDS JTY_2123 NC_012207.1 2343772 2345379 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 57 bp in-frame deletion at the NH2 part, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (535 aa versus 554 aa); hypothetical protein complement(2343772..2345379) Mycobacterium bovis BCG str. Tokyo 172 7561281 YP_002645176.1 CDS JTY_2124 NC_012207.1 2345440 2346633 D Differs from Mb2137 by 1aa, S278L, and from Rv2113 by 1aa, P207T in BCG Pasteur and BCG Tokyo; integral membrane protein 2345440..2346633 Mycobacterium bovis BCG str. Tokyo 172 7561282 YP_002645177.1 CDS JTY_2125 NC_012207.1 2346644 2347267 D hypothetical protein 2346644..2347267 Mycobacterium bovis BCG str. Tokyo 172 7561283 YP_002645178.1 CDS JTY_2126 NC_012207.1 2347271 2349100 R ATPase complement(2347271..2349100) Mycobacterium bovis BCG str. Tokyo 172 7561284 YP_002645179.1 CDS lppK NC_012207.1 2349381 2349950 D lipoprotein 2349381..2349950 Mycobacterium bovis BCG str. Tokyo 172 7561285 YP_002645180.1 CDS JTY_2128 NC_012207.1 2349958 2350251 D hypothetical protein 2349958..2350251 Mycobacterium bovis BCG str. Tokyo 172 7560476 YP_002645181.1 CDS JTY_2129 NC_012207.1 2350280 2351122 R RNA methyltransferase complement(2350280..2351122) Mycobacterium bovis BCG str. Tokyo 172 7564333 YP_002645182.1 CDS JTY_2130 NC_012207.1 2351196 2352032 D hypothetical protein 2351196..2352032 Mycobacterium bovis BCG str. Tokyo 172 7564334 YP_002645183.1 CDS JTY_2131 NC_012207.1 2352055 2352537 R integral membrane protein complement(2352055..2352537) Mycobacterium bovis BCG str. Tokyo 172 7564335 YP_002645184.1 CDS hisG NC_012207.1 2352616 2353470 R long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase complement(2352616..2353470) Mycobacterium bovis BCG str. Tokyo 172 7564336 YP_002645185.1 CDS hisE NC_012207.1 2353473 2353754 R catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase complement(2353473..2353754) Mycobacterium bovis BCG str. Tokyo 172 7563315 YP_002645186.1 CDS PPE37 NC_012207.1 2353881 2355275 D In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 27 bp in-frame deletion leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 473 aa); PPE family protein 2353881..2355275 Mycobacterium bovis BCG str. Tokyo 172 7563313 YP_002645187.1 CDS metH NC_012207.1 2355272 2358850 R Differs from Rv2124c by 1aa, V752I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methionine synthase, vitamin-B12 dependent isozyme, MS; 5-methyltetrahydrofolate--homocysteine methyltransferase complement(2355272..2358850) Mycobacterium bovis BCG str. Tokyo 172 7562177 YP_002645188.1 CDS JTY_2136 NC_012207.1 2359076 2359954 D Differs from Rv2125 by 1aa, S33G in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2359076..2359954 Mycobacterium bovis BCG str. Tokyo 172 7564461 YP_002645189.1 CDS PE_PGRS37 NC_012207.1 2359985 2360755 R PE-PGRS family protein complement(2359985..2360755) Mycobacterium bovis BCG str. Tokyo 172 7564337 YP_002645190.1 CDS ansP1 NC_012207.1 2361399 2362868 D Differs from Rv2127 by 2aa, D9G, S44G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; L-asparagine permease 2361399..2362868 Mycobacterium bovis BCG str. Tokyo 172 7561781 YP_002645191.1 CDS JTY_2139 NC_012207.1 2362868 2363071 D transmembrane protein 2362868..2363071 Mycobacterium bovis BCG str. Tokyo 172 7563977 YP_002645192.1 CDS JTY_2140 NC_012207.1 2363091 2363972 R short chain dehydrogenase complement(2363091..2363972) Mycobacterium bovis BCG str. Tokyo 172 7564338 YP_002645193.1 CDS cysS2 NC_012207.1 2363998 2365242 R catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase complement(2363998..2365242) Mycobacterium bovis BCG str. Tokyo 172 7564339 YP_002645194.1 CDS cysQ NC_012207.1 2365300 2366103 R hypothetical protein complement(2365300..2366103) Mycobacterium bovis BCG str. Tokyo 172 7561460 YP_002645195.1 CDS JTY_2143 NC_012207.1 2366194 2366424 D hypothetical protein 2366194..2366424 Mycobacterium bovis BCG str. Tokyo 172 7563182 YP_002645196.1 CDS JTY_2144 NC_012207.1 2366634 2367422 R hypothetical protein complement(2366634..2367422) Mycobacterium bovis BCG str. Tokyo 172 7564340 YP_002645197.1 CDS JTY_2145 NC_012207.1 2367433 2368020 R hypothetical protein complement(2367433..2368020) Mycobacterium bovis BCG str. Tokyo 172 7564341 YP_002645198.1 CDS JTY_2146 NC_012207.1 2368084 2368794 R hypothetical protein complement(2368084..2368794) Mycobacterium bovis BCG str. Tokyo 172 7564342 YP_002645199.1 CDS JTY_2147 NC_012207.1 2368791 2369621 R BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase complement(2368791..2369621) Mycobacterium bovis BCG str. Tokyo 172 7564343 YP_002645200.1 CDS JTY_2148 NC_012207.1 2369685 2370098 R hypothetical protein complement(2369685..2370098) Mycobacterium bovis BCG str. Tokyo 172 7564344 YP_002645201.1 CDS lppL NC_012207.1 2370113 2371189 D Differs from Mb2162 by 3aa, VQV348-350SRF, due to 7bp substitution in latter, tccaggt-gtccagg in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 2370113..2371189 Mycobacterium bovis BCG str. Tokyo 172 7564345 YP_002645202.1 CDS pyrD NC_012207.1 2371503 2372576 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 2371503..2372576 Mycobacterium bovis BCG str. Tokyo 172 7560477 YP_002645203.1 CDS TB18.6 NC_012207.1 2372581 2373111 R hypothetical protein complement(2372581..2373111) Mycobacterium bovis BCG str. Tokyo 172 7560872 YP_002645204.1 CDS JTY_2152 NC_012207.1 2373159 2374505 R hypothetical protein complement(2373159..2374505) Mycobacterium bovis BCG str. Tokyo 172 7561831 YP_002645205.1 CDS JTY_2153 NC_012207.1 2374976 2375293 R hypothetical protein complement(2374976..2375293) Mycobacterium bovis BCG str. Tokyo 172 7562819 YP_002645206.1 CDS JTY_2154 NC_012207.1 2375760 2376818 D hypothetical protein 2375760..2376818 Mycobacterium bovis BCG str. Tokyo 172 7564347 YP_002645207.1 CDS JTY_2155 NC_012207.1 2376948 2377304 R transmembrane protein complement(2376948..2377304) Mycobacterium bovis BCG str. Tokyo 172 7564348 YP_002645208.1 CDS wag31 NC_012207.1 2377399 2378181 R hypothetical protein complement(2377399..2378181) Mycobacterium bovis BCG str. Tokyo 172 7564349 YP_002645209.1 CDS JTY_2157 NC_012207.1 2378449 2378739 R transmembrane protein complement(2378449..2378739) Mycobacterium bovis BCG str. Tokyo 172 7561685 YP_002645210.1 CDS JTY_2158 NC_012207.1 2378901 2379626 R hypothetical protein complement(2378901..2379626) Mycobacterium bovis BCG str. Tokyo 172 7564350 YP_002645211.1 CDS JTY_2159 NC_012207.1 2379623 2380399 R hypothetical protein complement(2379623..2380399) Mycobacterium bovis BCG str. Tokyo 172 7564351 YP_002645212.1 CDS yfiH NC_012207.1 2380405 2381157 R hypothetical protein complement(2380405..2381157) Mycobacterium bovis BCG str. Tokyo 172 7564352 YP_002645213.1 CDS ftsZ NC_012207.1 2381168 2382307 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(2381168..2382307) Mycobacterium bovis BCG str. Tokyo 172 7561704 YP_002645214.1 CDS ftsQ NC_012207.1 2382480 2383424 R cell division protein complement(2382480..2383424) Mycobacterium bovis BCG str. Tokyo 172 7561883 YP_002645215.1 CDS murC NC_012207.1 2383421 2384905 R Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase complement(2383421..2384905) Mycobacterium bovis BCG str. Tokyo 172 7561879 YP_002645216.1 CDS murG NC_012207.1 2384902 2386134 R UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDP diphospho-muramoyl pentapeptide beta-N acetylglucosaminyl transferase complement(2384902..2386134) Mycobacterium bovis BCG str. Tokyo 172 7563573 YP_002645217.1 CDS ftsW NC_012207.1 2386034 2387704 R In Mycobacterium bovis BCG Tokyo, 1bp deletion at 1402:C of Mycobacterium tuberculosis, Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, leads to a shortly larger product compared with its homolog in Mycobacterium tuberculosis (Rv2154c), Mycobacterium bovis, and BCG Pasteur (553aa vs 524aa) and leads to product with different C-terminal part.; FtsW-like protein complement(2386034..2387704) Mycobacterium bovis BCG str. Tokyo 172 7563577 YP_002645218.1 CDS murD NC_012207.1 2387716 2389176 R UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase complement(2387716..2389176) Mycobacterium bovis BCG str. Tokyo 172 7561880 YP_002645219.1 CDS mraY NC_012207.1 2389178 2390257 R First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase complement(2389178..2390257) Mycobacterium bovis BCG str. Tokyo 172 7563574 YP_002645220.1 CDS murF NC_012207.1 2390254 2391786 R UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate-D-alanyl-D-alanyl ligase complement(2390254..2391786) Mycobacterium bovis BCG str. Tokyo 172 7563559 YP_002645221.1 CDS murE NC_012207.1 2391783 2393390 R involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase complement(2391783..2393390) Mycobacterium bovis BCG str. Tokyo 172 7563576 YP_002645222.1 CDS JTY_2170 NC_012207.1 2393413 2394447 R hypothetical protein complement(2393413..2394447) Mycobacterium bovis BCG str. Tokyo 172 7563575 YP_002645223.1 CDS JTY_2171 NC_012207.1 2394444 2395064 R In Mycobacterium tuberculosis strain H37Rv, Rv2160A and Rv2160c exist as 2 genes with an overlap region between them. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 4 bp insertion (*-GGAA) leads to a single product; hypothetical protein complement(2394444..2395064) Mycobacterium bovis BCG str. Tokyo 172 7564353 YP_002645224.1 CDS JTY_2172 NC_012207.1 2395057 2395923 R hypothetical protein complement(2395057..2395923) Mycobacterium bovis BCG str. Tokyo 172 7564354 YP_002645225.1 CDS PE_PGRS38 NC_012207.1 2396026 2397498 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, in-frame deletions of 108 bp and 18 bp leads to a shorter product than in Mycobacterium tuberculosis strain H37Rv (490 aa versus 532 aa); PE-PGRS family protein complement(2396026..2397498) Mycobacterium bovis BCG str. Tokyo 172 7564355 YP_002645226.1 CDS pbpB NC_012207.1 2397708 2399747 R penicillin-binding membrane protein complement(2397708..2399747) Mycobacterium bovis BCG str. Tokyo 172 7561782 YP_002645227.1 CDS JTY_2175 NC_012207.1 2399744 2400898 R Differs from Mb2188c by 1aa, V202A in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; proline rich membrane protein complement(2399744..2400898) Mycobacterium bovis BCG str. Tokyo 172 7562519 YP_002645228.1 CDS mraW NC_012207.1 2400895 2402085 R S-adenosyl-methyltransferase MraW complement(2400895..2402085) Mycobacterium bovis BCG str. Tokyo 172 7564356 YP_002645229.1 CDS JTY_2177 NC_012207.1 2402087 2402518 R MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ complement(2402087..2402518) Mycobacterium bovis BCG str. Tokyo 172 7563558 YP_002645230.1 CDS JTY_2178 NC_012207.1 2402867 2403271 R transmembrane protein complement(2402867..2403271) Mycobacterium bovis BCG str. Tokyo 172 7564357 YP_002645231.1 CDS JTY_2179 NC_012207.1 2403537 2404157 D hypothetical protein 2403537..2404157 Mycobacterium bovis BCG str. Tokyo 172 7564358 YP_002645232.1 CDS lppM NC_012207.1 2404253 2404936 D lipoprotein 2404253..2404936 Mycobacterium bovis BCG str. Tokyo 172 7564359 YP_002645233.1 CDS JTY_2181 NC_012207.1 2404933 2405838 R hypothetical protein complement(2404933..2405838) Mycobacterium bovis BCG str. Tokyo 172 7560478 YP_002645234.1 CDS idsA2 NC_012207.1 2406149 2407207 D geranylgeranyl pyrophosphate synthetase 2406149..2407207 Mycobacterium bovis BCG str. Tokyo 172 7564360 YP_002645235.1 CDS JTY_2183 NC_012207.1 2407211 2408914 D Differs from Rv2174 and Mb2196 at 3'-end owing to frameshift due to 1 bp insertion (T) at position corresponding to H37Rv coordinates 2437401-2437402, and from Rv2174 by 1aa, S451A in BCG Pasteur and BCG Tokyo; transmembrane protein 2407211..2408914 Mycobacterium bovis BCG str. Tokyo 172 7563345 YP_002645236.1 CDS JTY_2184 NC_012207.1 2408749 2409189 R Differs from Rv2175c by 1aa, L17P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical regulatory protein complement(2408749..2409189) Mycobacterium bovis BCG str. Tokyo 172 7564361 YP_002645237.1 CDS pknL NC_012207.1 2409244 2410443 D Differs from Rv2176 by 1aa, A52S in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; transmembrane serine/threonine-protein kinase L 2409244..2410443 Mycobacterium bovis BCG str. Tokyo 172 7564362 YP_002645238.1 CDS JTY_2186 NC_012207.1 2410585 2411250 R Differs from Rv2177c by 1aa, K115T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transposase complement(2410585..2411250) Mycobacterium bovis BCG str. Tokyo 172 7562439 YP_002645239.1 CDS aroG NC_012207.1 2411635 2413023 R Differs from Rv2178c by 1aa, E265D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; 3-deoxy-D-arabino-heptulosonate7- phosphate synthase complement(2411635..2413023) Mycobacterium bovis BCG str. Tokyo 172 7564363 YP_002645240.1 CDS JTY_2188 NC_012207.1 2413114 2413620 R hypothetical protein complement(2413114..2413620) Mycobacterium bovis BCG str. Tokyo 172 7564001 YP_002645241.1 CDS JTY_2189 NC_012207.1 2413630 2414517 R Differs from Rv2180c by 1aa, T156P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein complement(2413630..2414517) Mycobacterium bovis BCG str. Tokyo 172 7564364 YP_002645242.1 CDS JTY_2190 NC_012207.1 2414605 2415888 D integral membrane protein 2414605..2415888 Mycobacterium bovis BCG str. Tokyo 172 7564365 YP_002645243.1 CDS JTY_2191 NC_012207.1 2415889 2416632 R 1-acylglycerol-3-phosphate O-acyltransferase complement(2415889..2416632) Mycobacterium bovis BCG str. Tokyo 172 7564366 YP_002645244.1 CDS JTY_2192 NC_012207.1 2416718 2417113 R hypothetical protein complement(2416718..2417113) Mycobacterium bovis BCG str. Tokyo 172 7564367 YP_002645245.1 CDS JTY_2193 NC_012207.1 2417110 2418249 R hypothetical protein complement(2417110..2418249) Mycobacterium bovis BCG str. Tokyo 172 7564368 YP_002645246.1 CDS TB16.3 NC_012207.1 2418369 2418803 R hypothetical protein complement(2418369..2418803) Mycobacterium bovis BCG str. Tokyo 172 7564369 YP_002645247.1 CDS JTY_2195 NC_012207.1 2418908 2419297 R hypothetical protein complement(2418908..2419297) Mycobacterium bovis BCG str. Tokyo 172 7561829 YP_002645248.1 CDS JTY_2196 NC_012207.1 2419463 2419975 D In Mycobacterium tuberculosis strain H37Rv, fadD15 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to single base deletion (T-*) splits fadD15 into 2 parts.; hypothetical protein 2419463..2419975 Mycobacterium bovis BCG str. Tokyo 172 7564370 YP_002645249.1 CDS fadD15 NC_012207.1 2419738 2421264 D In Mycobacterium tuberculosis strain H37Rv, fadD15 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to single base deletion (T-*) splits fadD15 into 2 parts. Differs from Rv2187 by 2aa, I8T, E287G in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; long-chain-fatty-acid-CoA ligase 2419738..2421264 Mycobacterium bovis BCG str. Tokyo 172 7564371 YP_002645250.1 CDS JTY_2198 NC_012207.1 2421295 2422452 R hypothetical protein complement(2421295..2422452) Mycobacterium bovis BCG str. Tokyo 172 7562921 YP_002645251.1 CDS JTY_2199 NC_012207.1 2422549 2423322 R hypothetical protein complement(2422549..2423322) Mycobacterium bovis BCG str. Tokyo 172 7564372 YP_002645252.1 CDS JTY_2200 NC_012207.1 2423417 2424574 R hypothetical protein complement(2423417..2424574) Mycobacterium bovis BCG str. Tokyo 172 7564373 YP_002645253.1 CDS JTY_2201 NC_012207.1 2425121 2427058 D contains 3'-5'exonuclease domain; hypothetical protein 2425121..2427058 Mycobacterium bovis BCG str. Tokyo 172 7564374 YP_002645254.1 CDS trpD NC_012207.1 2426933 2428045 R Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase complement(2426933..2428045) Mycobacterium bovis BCG str. Tokyo 172 7564375 YP_002645255.1 CDS ctaE NC_012207.1 2428203 2428814 D cytochrome c oxidase subunit III 2428203..2428814 Mycobacterium bovis BCG str. Tokyo 172 7561631 YP_002645256.1 CDS qcrC NC_012207.1 2428855 2429697 D cytochrome c subunit; ubiquinol-cytochrome c reductase 2428855..2429697 Mycobacterium bovis BCG str. Tokyo 172 7563130 YP_002645257.1 CDS qcrA NC_012207.1 2429694 2430983 D Differs from Rv2195 by 1aa, I281M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; Rieske iron-sulfur protein 2429694..2430983 Mycobacterium bovis BCG str. Tokyo 172 7561547 YP_002645258.1 CDS qcrB NC_012207.1 2430980 2432629 D cytochrome b subunit; ubiquinol-cytochrome c reductase 2430980..2432629 Mycobacterium bovis BCG str. Tokyo 172 7561545 YP_002645259.1 CDS JTY_2207 NC_012207.1 2432920 2433564 R Differs from Rv2197c by 1aa, S202A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein complement(2432920..2433564) Mycobacterium bovis BCG str. Tokyo 172 7561546 YP_002645260.1 CDS mmpS3 NC_012207.1 2433564 2434463 R hypothetical protein complement(2433564..2434463) Mycobacterium bovis BCG str. Tokyo 172 7564376 YP_002645261.1 CDS JTY_2209 NC_012207.1 2434649 2435068 R transmembrane protein complement(2434649..2435068) Mycobacterium bovis BCG str. Tokyo 172 7563513 YP_002645262.1 CDS ctaC NC_012207.1 2435076 2436167 R transmembrane cytochrome c oxidase subunit II complement(2435076..2436167) Mycobacterium bovis BCG str. Tokyo 172 7564377 YP_002645263.1 CDS asnB NC_012207.1 2436413 2438371 D asparagine synthetase 2436413..2438371 Mycobacterium bovis BCG str. Tokyo 172 7563128 YP_002645264.1 CDS adoK NC_012207.1 2438469 2439443 R adenosine kinase complement(2438469..2439443) Mycobacterium bovis BCG str. Tokyo 172 7562041 YP_002645265.1 CDS JTY_2213 NC_012207.1 2439647 2440339 D hypothetical protein 2439647..2440339 Mycobacterium bovis BCG str. Tokyo 172 7563948 YP_002645266.1 CDS JTY_2214 NC_012207.1 2440347 2440703 R hypothetical protein complement(2440347..2440703) Mycobacterium bovis BCG str. Tokyo 172 7564378 YP_002645267.1 CDS JTY_2215 NC_012207.1 2440803 2441879 R hypothetical protein complement(2440803..2441879) Mycobacterium bovis BCG str. Tokyo 172 7564379 YP_002645268.1 CDS JTY_2216 NC_012207.1 2442038 2442748 D transmembrane protein 2442038..2442748 Mycobacterium bovis BCG str. Tokyo 172 7564380 YP_002645269.1 CDS cobT NC_012207.1 2442827 2443912 D catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2442827..2443912 Mycobacterium bovis BCG str. Tokyo 172 7564381 YP_002645270.1 CDS cobS NC_012207.1 2443909 2444658 D catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 2443909..2444658 Mycobacterium bovis BCG str. Tokyo 172 7563118 YP_002645271.1 CDS JTY_2219 NC_012207.1 2444816 2446354 D integral membrane protein 2444816..2446354 Mycobacterium bovis BCG str. Tokyo 172 7563117 YP_002645272.1 CDS ilvE NC_012207.1 2446280 2447386 R catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase complement(2446280..2447386) Mycobacterium bovis BCG str. Tokyo 172 7564382 YP_002645273.1 CDS gcvT NC_012207.1 2447458 2448597 R catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T complement(2447458..2448597) Mycobacterium bovis BCG str. Tokyo 172 7562780 YP_002645274.1 CDS JTY_2222 NC_012207.1 2448606 2449742 D hypothetical protein 2448606..2449742 Mycobacterium bovis BCG str. Tokyo 172 7561911 YP_002645275.1 CDS pepB NC_012207.1 2449754 2451301 D catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 2449754..2451301 Mycobacterium bovis BCG str. Tokyo 172 7564383 YP_002645276.1 CDS ephD NC_012207.1 2451339 2453117 R short chain dehydrogenase complement(2451339..2453117) Mycobacterium bovis BCG str. Tokyo 172 7561742 YP_002645277.1 CDS dlaT NC_012207.1 2453381 2455042 D Differs from Rv2215 and Mb2238 by 1aa, V517L in BCG Pasteur and BCG Tokyo; dihydrolipoamide acetyltransferase 2453381..2455042 Mycobacterium bovis BCG str. Tokyo 172 7562869 YP_002645278.1 CDS JTY_2226 NC_012207.1 2455042 2455947 D hypothetical protein 2455042..2455947 Mycobacterium bovis BCG str. Tokyo 172 7561498 YP_002645279.1 CDS lipB NC_012207.1 2456000 2456692 D lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 2456000..2456692 Mycobacterium bovis BCG str. Tokyo 172 7564384 YP_002645280.1 CDS lipA NC_012207.1 2456689 2457624 D catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 2456689..2457624 Mycobacterium bovis BCG str. Tokyo 172 7562830 YP_002645281.1 CDS JTY_2229 NC_012207.1 2457651 2458403 D Differs from Rv2219 by 1aa, L74F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 2457651..2458403 Mycobacterium bovis BCG str. Tokyo 172 7562829 YP_002645282.1 CDS JTY_2230 NC_012207.1 2458410 2458832 R hypothetical protein complement(2458410..2458832) Mycobacterium bovis BCG str. Tokyo 172 7564385 YP_002645283.1 CDS glnA1 NC_012207.1 2459031 2460467 D glutamine synthetase 2459031..2460467 Mycobacterium bovis BCG str. Tokyo 172 7564386 YP_002645284.1 CDS glnE NC_012207.1 2460785 2463769 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(2460785..2463769) Mycobacterium bovis BCG str. Tokyo 172 7561926 YP_002645285.1 CDS glnA2 NC_012207.1 2463818 2465158 R glutamine synthetase complement(2463818..2465158) Mycobacterium bovis BCG str. Tokyo 172 7561932 YP_002645286.1 CDS JTY_2234 NC_012207.1 2465253 2466815 R Differs from Rv2223c and Mb2247c by 1aa, S307A in BCG Pasteur and BCG Tokyo; exported protease complement(2465253..2466815) Mycobacterium bovis BCG str. Tokyo 172 7561927 YP_002645287.1 CDS JTY_2235 NC_012207.1 2466877 2468439 R exported protease complement(2466877..2468439) Mycobacterium bovis BCG str. Tokyo 172 7564387 YP_002645288.1 CDS panB NC_012207.1 2469158 2470003 D catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 2469158..2470003 Mycobacterium bovis BCG str. Tokyo 172 7564388 YP_002645289.1 CDS JTY_2237 NC_012207.1 2470248 2471789 D Differs from Rv2226 and Mb2250 by 1aa, N299D andG31D, respectively, in BCG Pasteur and BCG Tokyo; hypothetical protein 2470248..2471789 Mycobacterium bovis BCG str. Tokyo 172 7562508 YP_002645290.1 CDS JTY_2238 NC_012207.1 2472347 2472667 D In Mycobacterium tuberculosis strain H37Rv, Rv2227 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 1bp to 2bp substitution (T-CC) splits Rv2227 in two parts; hypothetical protein 2472347..2472667 Mycobacterium bovis BCG str. Tokyo 172 7564320 YP_002645291.1 CDS JTY_2239 NC_012207.1 2472675 2473049 D In Mycobacterium tuberculosis strain H37Rv, Rv2227 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 1bp to 2bp substitution (T-CC) splits Rv2227 in two parts; hypothetical protein 2472675..2473049 Mycobacterium bovis BCG str. Tokyo 172 7564390 YP_002645292.1 CDS JTY_2240 NC_012207.1 2473061 2474155 R bifunctional RNase H/acid phosphatase complement(2473061..2474155) Mycobacterium bovis BCG str. Tokyo 172 7564391 YP_002645293.1 CDS JTY_2241 NC_012207.1 2474152 2474889 R Differs from Rv2229c by 1aa, Q239R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2474152..2474889) Mycobacterium bovis BCG str. Tokyo 172 7564392 YP_002645294.1 CDS JTY_2242 NC_012207.1 2474886 2476025 R hypothetical protein complement(2474886..2476025) Mycobacterium bovis BCG str. Tokyo 172 7564393 YP_002645295.1 CDS cobC NC_012207.1 2476022 2477116 R hypothetical protein complement(2476022..2477116) Mycobacterium bovis BCG str. Tokyo 172 7564394 YP_002645296.1 CDS JTY_2244 NC_012207.1 2477695 2478570 D hypothetical protein 2477695..2478570 Mycobacterium bovis BCG str. Tokyo 172 7563104 YP_002645297.1 CDS ptpA NC_012207.1 2478563 2479054 D phosphotyrosine protein phosphatase 2478563..2479054 Mycobacterium bovis BCG str. Tokyo 172 7564395 YP_002645298.1 CDS JTY_2246 NC_012207.1 2479054 2479869 D transmembrane protein 2479054..2479869 Mycobacterium bovis BCG str. Tokyo 172 7560852 YP_002645299.1 CDS cobD NC_012207.1 2479851 2480792 R CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group; cobalamin biosynthesis protein complement(2479851..2480792) Mycobacterium bovis BCG str. Tokyo 172 7564396 YP_002645300.1 CDS JTY_2248 NC_012207.1 2480906 2481673 D hypothetical protein 2480906..2481673 Mycobacterium bovis BCG str. Tokyo 172 7563105 YP_002645301.1 CDS ahpE NC_012207.1 2482132 2482593 R peroxiredoxin complement(2482132..2482593) Mycobacterium bovis BCG str. Tokyo 172 7561680 YP_002645302.1 CDS JTY_2250 NC_012207.1 2482593 2483069 R hypothetical protein complement(2482593..2483069) Mycobacterium bovis BCG str. Tokyo 172 7563953 YP_002645303.1 CDS JTY_2251 NC_012207.1 2483107 2483904 R Differs from Rv2240c by 1aa, K259T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2483107..2483904) Mycobacterium bovis BCG str. Tokyo 172 7564398 YP_002645304.1 CDS aceE NC_012207.1 2483956 2486661 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 2483956..2486661 Mycobacterium bovis BCG str. Tokyo 172 7564399 YP_002645305.1 CDS JTY_2253 NC_012207.1 2486721 2487965 D Differs from Rv2242 and Mb2266 by 1aa, T363A in BCG Pasteur and BCG Tokyo; hypothetical protein 2486721..2487965 Mycobacterium bovis BCG str. Tokyo 172 7563928 YP_002645306.1 CDS fabD NC_012207.1 2488204 2489112 D malonyl CoA-acyl carrier protein transacylase 2488204..2489112 Mycobacterium bovis BCG str. Tokyo 172 7564400 YP_002645307.1 CDS acpP NC_012207.1 2489188 2489535 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 2489188..2489535 Mycobacterium bovis BCG str. Tokyo 172 7562894 YP_002645308.1 CDS kasA NC_012207.1 2489532 2490782 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 2489532..2490782 Mycobacterium bovis BCG str. Tokyo 172 7563932 YP_002645309.1 CDS kasB NC_012207.1 2490813 2492129 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 2490813..2492129 Mycobacterium bovis BCG str. Tokyo 172 7562798 YP_002645310.1 CDS accD6 NC_012207.1 2492160 2493581 D acetyl/propionyl-CoA carboxylase subunit beta 2492160..2493581 Mycobacterium bovis BCG str. Tokyo 172 7562799 YP_002645311.1 CDS JTY_2259 NC_012207.1 2493689 2494093 D In Mycobacterium bovis and Mycobacterium tuberculosis, Rv2248 and Mb2272 exist as single gene. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, the ortholog is split into two parts owing to single base insertion in G-string (-G) at position equivalent to Mycobacterium tuberculosis position 2522481-2522482; hypothetical protein 2493689..2494093 Mycobacterium bovis BCG str. Tokyo 172 7563926 YP_002645312.1 CDS JTY_2260 NC_012207.1 2493801 2494505 D In Mycobacterium bovis and Mycobacterium tuberculosis, Rv2248 and Mb2272 exist as single gene. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, the ortholog is split into two parts owing to single base insertion in G-string (-G) at position equivalent to Mycobacterium tuberculosis position 2522481-2522482; hypothetical protein 2493801..2494505 Mycobacterium bovis BCG str. Tokyo 172 7564401 YP_002645313.1 CDS glpD1 NC_012207.1 2494574 2496124 R glycerol-3-phosphate dehydrogenase complement(2494574..2496124) Mycobacterium bovis BCG str. Tokyo 172 7564402 YP_002645314.1 CDS JTY_2262 NC_012207.1 2496118 2496687 R Differs from Mb2274c by 1aa, D68A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional regulatory protein complement(2496118..2496687) Mycobacterium bovis BCG str. Tokyo 172 7561937 YP_002645315.1 CDS JTY_2263 NC_012207.1 2496735 2498324 D In Mycobacterium tuberculosis H37Rv, Rv2250A and Rv2251 exist as 2 genes with an overlap region between them. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base deletion (G-*) leads to a single product; flavoprotein 2496735..2498324 Mycobacterium bovis BCG str. Tokyo 172 7564403 YP_002645316.1 CDS JTY_2264 NC_012207.1 2498321 2499250 D involved in the biosynthesis of phosphatidylinositol mannosides (PIMs); the enzyme from Mycobacterium tuberculosis can phosphorylate a variety of amphipathic lipids; diacylglycerol kinase 2498321..2499250 Mycobacterium bovis BCG str. Tokyo 172 7564404 YP_002645317.1 CDS JTY_2265 NC_012207.1 2499316 2499819 D hypothetical protein 2499316..2499819 Mycobacterium bovis BCG str. Tokyo 172 7564405 YP_002645318.1 CDS JTY_2266 NC_012207.1 2499852 2500307 R Differs from Rv2254c by 1aa, V68A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein complement(2499852..2500307) Mycobacterium bovis BCG str. Tokyo 172 7564406 YP_002645319.1 CDS JTY_2267 NC_012207.1 2500312 2500506 R hypothetical protein complement(2500312..2500506) Mycobacterium bovis BCG str. Tokyo 172 7564407 YP_002645320.1 CDS JTY_2268 NC_012207.1 2500673 2501206 R Differs from Rv2256c by 1aa, G26A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2500673..2501206) Mycobacterium bovis BCG str. Tokyo 172 7564408 YP_002645321.1 CDS JTY_2269 NC_012207.1 2501336 2502154 R hypothetical protein complement(2501336..2502154) Mycobacterium bovis BCG str. Tokyo 172 7564409 YP_002645322.1 CDS JTY_2270 NC_012207.1 2502168 2503229 R transcriptional regulatory protein complement(2502168..2503229) Mycobacterium bovis BCG str. Tokyo 172 7564410 YP_002645323.1 CDS adhE2 NC_012207.1 2503471 2504556 D zinc-dependent alcohol dehydrogenase 2503471..2504556 Mycobacterium bovis BCG str. Tokyo 172 7564411 YP_002645324.1 CDS JTY_2272 NC_012207.1 2504556 2505191 D hypothetical protein 2504556..2505191 Mycobacterium bovis BCG str. Tokyo 172 7563946 YP_002645325.1 CDS JTY_2273 NC_012207.1 2505268 2506776 R In Mycobacterium tuberculosis strain H37Rv, Rv2262cand Rv2261c exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 2 bp deletion (CT-*) results in a single product; hypothetical protein complement(2505268..2506776) Mycobacterium bovis BCG str. Tokyo 172 7564412 YP_002645326.1 CDS JTY_2274 NC_012207.1 2506865 2507818 D short chain dehydrogenase 2506865..2507818 Mycobacterium bovis BCG str. Tokyo 172 7564413 YP_002645327.1 CDS JTY_2275 NC_012207.1 2507796 2509574 R hypothetical protein complement(2507796..2509574) Mycobacterium bovis BCG str. Tokyo 172 7564414 YP_002645328.1 CDS JTY_2276 NC_012207.1 2509924 2511153 D transmembrane protein 2509924..2511153 Mycobacterium bovis BCG str. Tokyo 172 7562938 YP_002645329.1 CDS cyp124 NC_012207.1 2511328 2512614 D cytochrome P450 124 2511328..2512614 Mycobacterium bovis BCG str. Tokyo 172 7562939 YP_002645330.1 CDS JTY_2278 NC_012207.1 2512868 2514034 R hypothetical protein complement(2512868..2514034) Mycobacterium bovis BCG str. Tokyo 172 7563155 YP_002645331.1 CDS cyp128 NC_012207.1 2514031 2515500 R Differs from Rv2268c and Mb2291c by 1aa, F203L in BCG Pasteur and BCG Tokyo; cytochrome P450 128 complement(2514031..2515500) Mycobacterium bovis BCG str. Tokyo 172 7562940 YP_002645332.1 CDS JTY_2280 NC_012207.1 2515513 2515845 R hypothetical protein complement(2515513..2515845) Mycobacterium bovis BCG str. Tokyo 172 7563158 YP_002645333.1 CDS lppN NC_012207.1 2515922 2516449 D Differs from Mb2293 by 1aa, P152L in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 2515922..2516449 Mycobacterium bovis BCG str. Tokyo 172 7562941 YP_002645334.1 CDS JTY_2282 NC_012207.1 2516556 2516855 D hypothetical protein 2516556..2516855 Mycobacterium bovis BCG str. Tokyo 172 7560479 YP_002645335.1 CDS JTY_2283 NC_012207.1 2516961 2517329 D hypothetical protein 2516961..2517329 Mycobacterium bovis BCG str. Tokyo 172 7562942 YP_002645336.1 CDS JTY_2284 NC_012207.1 2517326 2517655 D transmembrane protein 2517326..2517655 Mycobacterium bovis BCG str. Tokyo 172 7562943 YP_002645337.1 CDS JTY_2285 NC_012207.1 2517712 2518029 R Differs from Rv2274c by 1aa, M33I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2517712..2518029) Mycobacterium bovis BCG str. Tokyo 172 7562944 YP_002645338.1 CDS JTY_2286 NC_012207.1 2518107 2518976 D Differs from Rv2275 and Mb2298 by 1aa, A261E in BCG Pasteur and BCG Tokyo; hypothetical protein 2518107..2518976 Mycobacterium bovis BCG str. Tokyo 172 7562945 YP_002645339.1 CDS cyp121 NC_012207.1 2518973 2520163 D cytochrome P450 121 2518973..2520163 Mycobacterium bovis BCG str. Tokyo 172 7562946 YP_002645340.1 CDS JTY_2288 NC_012207.1 2520348 2521247 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 1358 bp deletion containing an IS6110 sequence, disrupts the 5' start of Rv2277c resulting in a slightly shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (299 aa versus 301 aa). Differs from Mb2300c by 1aa in BCG Pasteur and BCG Tokyo; glycerolphosphodiesterase complement(2520348..2521247) Mycobacterium bovis BCG str. Tokyo 172 7563153 YP_002645341.1 CDS JTY_2289 NC_012207.1 2521426 2522805 D dehydrogenase 2521426..2522805 Mycobacterium bovis BCG str. Tokyo 172 7562947 YP_002645342.1 CDS pitB NC_012207.1 2523039 2524697 D phosphate-transport permease 2523039..2524697 Mycobacterium bovis BCG str. Tokyo 172 7562948 YP_002645343.1 CDS JTY_2291 NC_012207.1 2524804 2525742 R LysR-family; transcription regulator complement(2524804..2525742) Mycobacterium bovis BCG str. Tokyo 172 7562427 YP_002645344.1 CDS JTY_2292 NC_012207.1 2525807 2526001 D hypothetical protein 2525807..2526001 Mycobacterium bovis BCG str. Tokyo 172 7562949 YP_002645345.1 CDS lipM NC_012207.1 2526011 2527306 D esterase 2526011..2527306 Mycobacterium bovis BCG str. Tokyo 172 7562950 YP_002645346.1 CDS JTY_2294 NC_012207.1 2527339 2528676 D hypothetical protein 2527339..2528676 Mycobacterium bovis BCG str. Tokyo 172 7562840 YP_002645347.1 CDS JTY_2295 NC_012207.1 2528743 2529006 R In Mycobacterium tuberculosis strain H37Rv, Rv2286c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, an in-frame stop codon due to a single base transition (C-T) splits Rv2286c into 2 parts; hypothetical protein complement(2528743..2529006) Mycobacterium bovis BCG str. Tokyo 172 7562951 YP_002645348.1 CDS JTY_2296 NC_012207.1 2529034 2529435 R In Mycobacterium tuberculosis strain H37Rv, Rv2286c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, an in-frame stop codon due to a single base transition (C-T) splits Rv2286c into 2 parts; hypothetical protein complement(2529034..2529435) Mycobacterium bovis BCG str. Tokyo 172 7562952 YP_002645349.1 CDS yjcE NC_012207.1 2529569 2531197 D integral membrane transport protein 2529569..2531197 Mycobacterium bovis BCG str. Tokyo 172 7562953 YP_002645350.1 CDS JTY_2298 NC_012207.1 2531194 2531571 D hypothetical protein 2531194..2531571 Mycobacterium bovis BCG str. Tokyo 172 7561705 YP_002645351.1 CDS cdh NC_012207.1 2531541 2532323 D CDP-diacylglycerol pyrophosphatase 2531541..2532323 Mycobacterium bovis BCG str. Tokyo 172 7562954 YP_002645352.1 CDS lppOa NC_012207.1 2532465 2532620 D In Mycobacterium tuberculosis strain H37Rv, Rv2290 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*), splits lppO into 2 parts, lppOa and lppOb; lipoprotein 2532465..2532620 Mycobacterium bovis BCG str. Tokyo 172 7562090 YP_002645353.1 CDS lppOb NC_012207.1 2532614 2532979 D In Mycobacterium tuberculosis strain H37Rv, Rv2290 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*), splits lppO into 2 parts, lppOa and lppOb; lipoprotein 2532614..2532979 Mycobacterium bovis BCG str. Tokyo 172 7560480 YP_002645354.1 CDS sseB NC_012207.1 2533039 2533893 D In Mycobacterium bovis, truncation at the 5' start due to a 2 bp deletion (TG-*), leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (256 aa versus 284 aa). Differs from Rv2291 by 1aa, A262E; thiosulfate sulfurtransferase 2533039..2533893 Mycobacterium bovis BCG str. Tokyo 172 7560481 YP_002645355.1 CDS JTY_2303 NC_012207.1 2533894 2534898 R In Mycobacterium tuberculosis strain H37Rv, Rv2293c and Rv2292c exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base insertion (*-G) results in a single product; hypothetical protein complement(2533894..2534898) Mycobacterium bovis BCG str. Tokyo 172 7561809 YP_002645356.1 CDS JTY_2304 NC_012207.1 2535193 2536416 D aminotransferase 2535193..2536416 Mycobacterium bovis BCG str. Tokyo 172 7562955 YP_002645357.1 CDS JTY_2305 NC_012207.1 2536639 2537277 D hypothetical protein 2536639..2537277 Mycobacterium bovis BCG str. Tokyo 172 7562956 YP_002645358.1 CDS JTY_2306 NC_012207.1 2537371 2538273 D haloalkane dehalogenase 2537371..2538273 Mycobacterium bovis BCG str. Tokyo 172 7562957 YP_002645359.1 CDS JTY_2307 NC_012207.1 2538305 2538757 D hypothetical protein 2538305..2538757 Mycobacterium bovis BCG str. Tokyo 172 7562958 YP_002645360.1 CDS JTY_2308 NC_012207.1 2538949 2539920 D hypothetical protein 2538949..2539920 Mycobacterium bovis BCG str. Tokyo 172 7562959 YP_002645361.1 CDS htpG NC_012207.1 2539926 2541869 R molecular chaperone; heat shock protein 90 complement(2539926..2541869) Mycobacterium bovis BCG str. Tokyo 172 7562960 YP_002645362.1 CDS JTY_2310 NC_012207.1 2541943 2542875 R hypothetical protein complement(2541943..2542875) Mycobacterium bovis BCG str. Tokyo 172 7563331 YP_002645363.1 CDS cut2 NC_012207.1 2542882 2543574 D cutinase 2542882..2543574 Mycobacterium bovis BCG str. Tokyo 172 7562961 YP_002645364.1 CDS JTY_2312 NC_012207.1 2543680 2543922 D hypothetical protein 2543680..2543922 Mycobacterium bovis BCG str. Tokyo 172 7563143 YP_002645365.1 CDS JTY_2313 NC_012207.1 2543963 2544886 R antibiotic-resistance protein complement(2543963..2544886) Mycobacterium bovis BCG str. Tokyo 172 7562962 YP_002645366.1 CDS JTY_2314 NC_012207.1 2544883 2545092 R hypothetical protein complement(2544883..2545092) Mycobacterium bovis BCG str. Tokyo 172 7562963 YP_002645367.1 CDS JTY_2315 NC_012207.1 2545676 2546965 D Differs from Rv2305 by 1aa, D148G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2545676..2546965 Mycobacterium bovis BCG str. Tokyo 172 7562964 YP_002645368.1 CDS JTY_2316 NC_012207.1 2546975 2547568 D Differs from Rv2306A by 1aa, V47I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2546975..2547568 Mycobacterium bovis BCG str. Tokyo 172 7562965 YP_002645369.1 CDS JTY_2317 NC_012207.1 2547355 2547789 D hypothetical protein 2547355..2547789 Mycobacterium bovis BCG str. Tokyo 172 7562966 YP_002645370.1 CDS JTY_2318 NC_012207.1 2547718 2548563 R Differs from Rv2307c by 2aa, T24M, W235R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2547718..2548563) Mycobacterium bovis BCG str. Tokyo 172 7562967 YP_002645371.1 CDS JTY_2319 NC_012207.1 2549095 2549286 R hypothetical glycine rich protein complement(2549095..2549286) Mycobacterium bovis BCG str. Tokyo 172 7562968 YP_002645372.1 CDS JTY_2320 NC_012207.1 2549371 2549802 R hypothetical glycine rich protein complement(2549371..2549802) Mycobacterium bovis BCG str. Tokyo 172 7562969 YP_002645373.1 CDS JTY_2321 NC_012207.1 2549895 2550077 R hypothetical protein complement(2549895..2550077) Mycobacterium bovis BCG str. Tokyo 172 7562970 YP_002645374.1 CDS JTY_2322 NC_012207.1 2550286 2551002 D Differs from Rv2308 by 1aa, V43G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2550286..2551002 Mycobacterium bovis BCG str. Tokyo 172 7562971 YP_002645375.1 CDS JTY_2323 NC_012207.1 2551710 2552165 R integrase complement(2551710..2552165) Mycobacterium bovis BCG str. Tokyo 172 7564466 YP_002645376.1 CDS JTY_2324 NC_012207.1 2552912 2553199 D Differs from Rv2309A by 1aa, K53E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2552912..2553199 Mycobacterium bovis BCG str. Tokyo 172 7562973 YP_002645377.1 CDS JTY_2325 NC_012207.1 2553302 2553646 D excisionase 2553302..2553646 Mycobacterium bovis BCG str. Tokyo 172 7562974 YP_002645378.1 CDS JTY_2326 NC_012207.1 2553751 2554275 D hypothetical protein 2553751..2554275 Mycobacterium bovis BCG str. Tokyo 172 7562975 YP_002645379.1 CDS JTY_2327 NC_012207.1 2554353 2554622 D hypothetical protein 2554353..2554622 Mycobacterium bovis BCG str. Tokyo 172 7562976 YP_002645380.1 CDS JTY_2328 NC_012207.1 2554919 2555773 R hypothetical protein complement(2554919..2555773) Mycobacterium bovis BCG str. Tokyo 172 7562977 YP_002645381.1 CDS JTY_2329 NC_012207.1 2555784 2557157 R hypothetical protein complement(2555784..2557157) Mycobacterium bovis BCG str. Tokyo 172 7562978 YP_002645382.1 CDS JTY_2330 NC_012207.1 2557154 2558671 R hypothetical protein complement(2557154..2558671) Mycobacterium bovis BCG str. Tokyo 172 7562979 YP_002645383.1 CDS uspA NC_012207.1 2558705 2559577 D Differs from Rv2316 by 1aa, L126V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; sugar-transport integral membrane protein ABC transporter 2558705..2559577 Mycobacterium bovis BCG str. Tokyo 172 7562980 YP_002645384.1 CDS uspB NC_012207.1 2559564 2560388 D sugar-transport integral membrane protein ABC transporter 2559564..2560388 Mycobacterium bovis BCG str. Tokyo 172 7561669 YP_002645385.1 CDS uspC NC_012207.1 2560385 2561707 D Differs from Rv2318 by 1aa, V354L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; periplasmic sugar-binding lipoprotein 2560385..2561707 Mycobacterium bovis BCG str. Tokyo 172 7561670 YP_002645386.1 CDS JTY_2334 NC_012207.1 2561715 2562593 R Differs from Rv2319c and Mb2346c by 1aa, G105E in BCG Pasteur and BCG Tokyo; hypothetical protein complement(2561715..2562593) Mycobacterium bovis BCG str. Tokyo 172 7561671 YP_002645387.1 CDS rocE NC_012207.1 2562590 2564020 R cationic amino acid transport integral membrane protein complement(2562590..2564020) Mycobacterium bovis BCG str. Tokyo 172 7562981 YP_002645388.1 CDS rocD2 NC_012207.1 2564021 2564566 R C-terminus part; ornithine aminotransferase complement(2564021..2564566) Mycobacterium bovis BCG str. Tokyo 172 7561593 YP_002645389.1 CDS rocD1 NC_012207.1 2564566 2565231 R N-terminus part; ornithine aminotransferase complement(2564566..2565231) Mycobacterium bovis BCG str. Tokyo 172 7561592 YP_002645390.1 CDS JTY_2338 NC_012207.1 2565228 2566136 R Differs from Rv2323c by 1aa, T113A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2565228..2566136) Mycobacterium bovis BCG str. Tokyo 172 7561591 YP_002645391.1 CDS JTY_2339 NC_012207.1 2566201 2566647 D probably AsnC-family; transcriptional regulatory protein 2566201..2566647 Mycobacterium bovis BCG str. Tokyo 172 7562982 YP_002645392.1 CDS JTY_2340 NC_012207.1 2566876 2567724 R hypothetical protein complement(2566876..2567724) Mycobacterium bovis BCG str. Tokyo 172 7562983 YP_002645393.1 CDS JTY_2341 NC_012207.1 2567721 2569814 R transmembrane ATP-binding protein ABC transporter complement(2567721..2569814) Mycobacterium bovis BCG str. Tokyo 172 7562984 YP_002645394.1 CDS JTY_2342 NC_012207.1 2569855 2570346 D hypothetical protein 2569855..2570346 Mycobacterium bovis BCG str. Tokyo 172 7562985 YP_002645395.1 CDS PE23 NC_012207.1 2570598 2571746 D PE family protein 2570598..2571746 Mycobacterium bovis BCG str. Tokyo 172 7562986 YP_002645396.1 CDS narK1 NC_012207.1 2571781 2573328 R nitrite extrusion protein 1 complement(2571781..2573328) Mycobacterium bovis BCG str. Tokyo 172 7561723 YP_002645397.1 CDS lppP NC_012207.1 2573562 2574089 R Differs from Rv2330c and Mb2357c by 1aa, A97S in BCG Pasteur and BCG Tokyo; lipoprotein complement(2573562..2574089) Mycobacterium bovis BCG str. Tokyo 172 7562449 YP_002645398.1 CDS JTY_2346 NC_012207.1 2574164 2574550 D hypothetical protein 2574164..2574550 Mycobacterium bovis BCG str. Tokyo 172 7560482 YP_002645399.1 CDS JTY_2347 NC_012207.1 2574607 2574945 D Differs from Rv2331A by 1aa, L46I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2574607..2574945 Mycobacterium bovis BCG str. Tokyo 172 7562987 YP_002645400.1 CDS mez NC_012207.1 2574975 2576621 D malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 2574975..2576621 Mycobacterium bovis BCG str. Tokyo 172 7562988 YP_002645401.1 CDS JTY_2349 NC_012207.1 2576618 2578189 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, single base insertion (*-G) leads to a slightly longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (523 aa versus 537 aa). Also differs from Rv2333c by 2aa, Y69D, Q503H in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; integral membrane transport protein complement(2576618..2578189) Mycobacterium bovis BCG str. Tokyo 172 7564469 YP_002645402.1 CDS cysK1 NC_012207.1 2578664 2579596 D cysteine synthase A 2578664..2579596 Mycobacterium bovis BCG str. Tokyo 172 7562989 YP_002645403.1 CDS JTY_2351 NC_012207.1 2579600 2580289 D serine acetyltransferase 2579600..2580289 Mycobacterium bovis BCG str. Tokyo 172 7563178 YP_002645404.1 CDS JTY_2352 NC_012207.1 2580705 2581673 D hypothetical protein 2580705..2581673 Mycobacterium bovis BCG str. Tokyo 172 7562990 YP_002645405.1 CDS JTY_2353 NC_012207.1 2581737 2582855 R Differs from Rv2337c by 1aa, V119G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2581737..2582855) Mycobacterium bovis BCG str. Tokyo 172 7562991 YP_002645406.1 CDS moeW NC_012207.1 2582975 2583931 R hypothetical protein complement(2582975..2583931) Mycobacterium bovis BCG str. Tokyo 172 7562992 YP_002645407.1 CDS mmpL9a NC_012207.1 2584562 2587042 D In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (G-A) splits mmpL9 into 2 parts, mmpL9a and mmpL9b; transmembrane transport protein 2584562..2587042 Mycobacterium bovis BCG str. Tokyo 172 7563543 YP_002645408.1 CDS mmpL9b NC_012207.1 2587055 2587450 D In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (G-A) splits mmpL9 into 2 parts, mmpL9a and mmpL9b; transmembrane transport protein 2587055..2587450 Mycobacterium bovis BCG str. Tokyo 172 7564494 YP_002645409.1 CDS PE_PGRS39 NC_012207.1 2587536 2588777 R Differs from Rv2340c and Mb2369c by 1aa, T222D in BCG Pasteur and BCG Tokyo; PE-PGRS family protein complement(2587536..2588777) Mycobacterium bovis BCG str. Tokyo 172 7564495 YP_002645410.1 CDS lppQ NC_012207.1 2589466 2589885 D lipoprotein lppQ 2589466..2589885 Mycobacterium bovis BCG str. Tokyo 172 7562042 YP_002645411.1 CDS JTY_2359 NC_012207.1 2590141 2590398 D hypothetical protein 2590141..2590398 Mycobacterium bovis BCG str. Tokyo 172 7560483 YP_002645412.1 CDS dnaG NC_012207.1 2590402 2592321 R synthesizes RNA primers at the replication forks; DNA primase complement(2590402..2592321) Mycobacterium bovis BCG str. Tokyo 172 7562993 YP_002645413.1 CDS dgt NC_012207.1 2592326 2593621 R dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein complement(2592326..2593621) Mycobacterium bovis BCG str. Tokyo 172 7561503 YP_002645414.1 CDS JTY_2362 NC_012207.1 2593690 2595672 D transmembrane protein 2593690..2595672 Mycobacterium bovis BCG str. Tokyo 172 7561491 YP_002645415.1 CDS esxO NC_012207.1 2595757 2595939 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 8963 bp deletion (RD5) leads to the loss of the NH2 part of Rv2346c, and the 9 following CDSs up to Rv2356 including the 3 phospolipases C enzymes plcC, plcB and plcA, compared to the homolog in Mycobacterium tuberculosis H37Rv; EsaT-6 like protein 6 complement(2595757..2595939) Mycobacterium bovis BCG str. Tokyo 172 7562994 YP_002645416.1 CDS PPE71 NC_012207.1 2595923 2597329 R Compared to Mycobacterium bovis, there has been a 2579bp bp deletion at position equivalent to M. bovis 2604493-2607071, this has resulted in an in-frame fusion of the 5'-end of PPE40 with the 3'-end of PPE71 probably due to a homologous recombination event between codons 68 and 174 of PPE40 as the PPE40 and PPE71 genes have identical 5'-ends (first 535 bp). Differs from Mb2376c(PPE71) by extra 11aa, insertion of A at position 68 due to 3bp insertion (present in PPE40) and STNVGSGNIG at position 307 due to 30 bp insertion. M. bovis BCG Pasteur and BCG Tokyo thus has three copies of tandem repeat STNVGSGNIG compared to two in Mb2376c. The 3'-end of PPE71 of M. bovis BCG Pasteur and BCG Tokyo have also been truncated as a result of the same deletion described in In Mycobacterium bovis, 8963 bp deletion (RD5); PPE family protein complement(2595923..2597329) Mycobacterium bovis BCG str. Tokyo 172 7562886 YP_002645417.1 CDS glyS NC_012207.1 2597467 2598858 R Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase complement(2597467..2598858) Mycobacterium bovis BCG str. Tokyo 172 7560802 YP_002645418.1 CDS JTY_2366 NC_012207.1 2599040 2599447 D probably ArsR-family; transcriptional regulatory protein 2599040..2599447 Mycobacterium bovis BCG str. Tokyo 172 7563266 YP_002645419.1 CDS furB NC_012207.1 2599444 2599836 D Differs from Rv2359 by 1aa, R64H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; ferric uptake regulation protein 2599444..2599836 Mycobacterium bovis BCG str. Tokyo 172 7562995 YP_002645420.1 CDS JTY_2368 NC_012207.1 2599944 2600372 R Differs from Rv2360c by 1aa, T66A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2599944..2600372) Mycobacterium bovis BCG str. Tokyo 172 7561887 YP_002645421.1 CDS JTY_2369 NC_012207.1 2600372 2601262 R catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; UDP pyrophosphate synthase complement(2600372..2601262) Mycobacterium bovis BCG str. Tokyo 172 7562996 YP_002645422.1 CDS recO NC_012207.1 2601255 2602052 R involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO complement(2601255..2602052) Mycobacterium bovis BCG str. Tokyo 172 7562997 YP_002645423.1 CDS amiA2 NC_012207.1 2602114 2603568 D catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 2602114..2603568 Mycobacterium bovis BCG str. Tokyo 172 7561561 YP_002645424.1 CDS era NC_012207.1 2603565 2604467 R Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era complement(2603565..2604467) Mycobacterium bovis BCG str. Tokyo 172 7563968 YP_002645425.1 CDS JTY_2373 NC_012207.1 2604541 2604882 R hypothetical protein complement(2604541..2604882) Mycobacterium bovis BCG str. Tokyo 172 7562872 YP_002645426.1 CDS JTY_2374 NC_012207.1 2604854 2606161 R transmembrane protein complement(2604854..2606161) Mycobacterium bovis BCG str. Tokyo 172 7562998 YP_002645427.1 CDS JTY_2375 NC_012207.1 2606158 2606706 R metalloprotease complement(2606158..2606706) Mycobacterium bovis BCG str. Tokyo 172 7562999 YP_002645428.1 CDS phoH1 NC_012207.1 2606710 2607768 R phoH-like protein complement(2606710..2607768) Mycobacterium bovis BCG str. Tokyo 172 7563000 YP_002645429.1 CDS JTY_2377 NC_012207.1 2607740 2608042 R hypothetical protein complement(2607740..2608042) Mycobacterium bovis BCG str. Tokyo 172 7562409 YP_002645430.1 CDS JTY_2378 NC_012207.1 2608039 2609352 R hypothetical protein complement(2608039..2609352) Mycobacterium bovis BCG str. Tokyo 172 7563001 YP_002645431.1 CDS PE_PGRS40 NC_012207.1 2609547 2609732 D PE-PGRS family protein 2609547..2609732 Mycobacterium bovis BCG str. Tokyo 172 7563002 YP_002645432.1 CDS JTY_2380 NC_012207.1 2609831 2610619 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(2609831..2610619) Mycobacterium bovis BCG str. Tokyo 172 7561787 YP_002645433.1 CDS dnaJ2 NC_012207.1 2610633 2611781 R chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ complement(2610633..2611781) Mycobacterium bovis BCG str. Tokyo 172 7563003 YP_002645434.1 CDS hrcA NC_012207.1 2611856 2612887 R Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor complement(2611856..2612887) Mycobacterium bovis BCG str. Tokyo 172 7561505 YP_002645435.1 CDS JTY_2383 NC_012207.1 2613059 2613376 D hypothetical protein 2613059..2613376 Mycobacterium bovis BCG str. Tokyo 172 7563324 YP_002645436.1 CDS cfp2 NC_012207.1 2613403 2613909 R low molecular weight antigen complement(2613403..2613909) Mycobacterium bovis BCG str. Tokyo 172 7563004 YP_002645437.1 CDS mbtH NC_012207.1 2614009 2614224 R Differs from Rv2377c by 1aa, A69V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2614009..2614224) Mycobacterium bovis BCG str. Tokyo 172 7562098 YP_002645438.1 CDS mbtG NC_012207.1 2614202 2615497 R lysine-N-oxygenase complement(2614202..2615497) Mycobacterium bovis BCG str. Tokyo 172 7564428 YP_002645439.1 CDS mbtF NC_012207.1 2615494 2619879 R Differs from Rv2379c by 1aa, D589E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; peptide synthetase complement(2615494..2619879) Mycobacterium bovis BCG str. Tokyo 172 7564427 YP_002645440.1 CDS mbtE NC_012207.1 2619861 2624909 R peptide synthetase complement(2619861..2624909) Mycobacterium bovis BCG str. Tokyo 172 7564426 YP_002645441.1 CDS mbtD NC_012207.1 2625049 2628063 R polyketide synthase complement(2625049..2628063) Mycobacterium bovis BCG str. Tokyo 172 7564425 YP_002645442.1 CDS mbtC NC_012207.1 2628063 2629397 R polyketide synthase complement(2628063..2629397) Mycobacterium bovis BCG str. Tokyo 172 7564424 YP_002645443.1 CDS mbtB NC_012207.1 2629387 2633631 R Differs from Rv2383c by 2aa, Q264R, P1253T, and from Mb2404c by 1aa, P1253T BCG Pasteur and BCG Tokyo; phenyloxazoline synthase complement(2629387..2633631) Mycobacterium bovis BCG str. Tokyo 172 7564423 YP_002645444.1 CDS mbtA NC_012207.1 2633730 2635427 D salicyl-S-ArCP synthetase; salicyl-AMP ligase 2633730..2635427 Mycobacterium bovis BCG str. Tokyo 172 7564422 YP_002645445.1 CDS mbtJ NC_012207.1 2635523 2636443 D acetyl hydrolase 2635523..2636443 Mycobacterium bovis BCG str. Tokyo 172 7564421 YP_002645446.1 CDS mbtI NC_012207.1 2636447 2637799 R catalyzes conversion of chorismate to salicylate, in mycobactin siderophore construction; requires Mg(2+) for function; salicylate synthase MbtI complement(2636447..2637799) Mycobacterium bovis BCG str. Tokyo 172 7564430 YP_002645447.1 CDS JTY_2395 NC_012207.1 2638559 2639812 D hypothetical protein 2638559..2639812 Mycobacterium bovis BCG str. Tokyo 172 7564429 YP_002645448.1 CDS hemN NC_012207.1 2639809 2640936 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(2639809..2640936) Mycobacterium bovis BCG str. Tokyo 172 7563005 YP_002645449.1 CDS rpfD NC_012207.1 2641042 2641506 R resuscitation-promoting factor complement(2641042..2641506) Mycobacterium bovis BCG str. Tokyo 172 7563304 YP_002645450.1 CDS JTY_2398 NC_012207.1 2641503 2642060 R Differs from Mb2411c by 1aa, I33T in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2641503..2642060) Mycobacterium bovis BCG str. Tokyo 172 7561599 YP_002645451.1 CDS nirA NC_012207.1 2642473 2644164 D ferredoxin-dependent nitrite reductase 2642473..2644164 Mycobacterium bovis BCG str. Tokyo 172 7563006 YP_002645452.1 CDS cysH NC_012207.1 2644161 2644925 D catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 2644161..2644925 Mycobacterium bovis BCG str. Tokyo 172 7562461 YP_002645453.1 CDS JTY_2401 NC_012207.1 2644922 2645821 D In Mycobacterium bovis BCG Pasteur and BCG Tokyo, duplication of 54 bp segment after codon 3 leads to additional 18 aa and two tandem copies of motif PATMQSAAMLRSGAIEAP, compared to its ortholog in Mycobacterium tuberculosis strain H37Rv and in Mycobacterium bovis AF2122/97; hypothetical protein 2644922..2645821 Mycobacterium bovis BCG str. Tokyo 172 7563177 YP_002645454.1 CDS ggtB NC_012207.1 2645858 2647789 D Differs from Rv2394 by 1aa Q396R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; gamma-glutamyltranspeptidase precursor 2645858..2647789 Mycobacterium bovis BCG str. Tokyo 172 7563007 YP_002645455.1 CDS JTY_2403 NC_012207.1 2647920 2648360 D In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, as in Mycobacterium bovis, a frameshift due to a single base insertion (*-T) splits Rv2395 into 2 parts. The frameshift occurs after the 44th codon; integral membrane protein 2647920..2648360 Mycobacterium bovis BCG str. Tokyo 172 7561914 YP_002645456.1 CDS JTY_2404 NC_012207.1 2648374 2649924 D In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-T) splits Rv2395 into 2 parts. BCG_2410 also differs from Rv2395 by 1aa, P396S in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; integral membrane protein 2648374..2649924 Mycobacterium bovis BCG str. Tokyo 172 7563008 YP_002645457.1 CDS PE_PGRS41 NC_012207.1 2650648 2651730 D Identical to Mb2418 of Mycobacterium bovis, including 3 bp deletion (GCC-*) that leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (360 aa versus 361 aa) due to deletion of A95 in BCG Pasteur and Tokyo. Also differs from Rv2396 by 2aa, N26S, S324N in BCG Pasteur. Differs from Rv2396 by 3aa, N26S, C218G, S324N in BCG Tokyo.; PE-PGRS family protein 2650648..2651730 Mycobacterium bovis BCG str. Tokyo 172 7563009 YP_002645458.1 CDS cysA1 NC_012207.1 2651755 2652810 R sulfate-transport ATP-binding protein ABC transporter complement(2651755..2652810) Mycobacterium bovis BCG str. Tokyo 172 7561788 YP_002645459.1 CDS cysW NC_012207.1 2652827 2653645 R Differs from Rv2398c by 1aa, A141G, and from Mb2420c by 1aa, R264H in BCG Pasteur and BCG Tokyo; sulfate-transport integral membrane protein ABC transporter complement(2652827..2653645) Mycobacterium bovis BCG str. Tokyo 172 7563172 YP_002645460.1 CDS cysT NC_012207.1 2653642 2654493 R sulfate-transport integral membrane protein ABC transporter complement(2653642..2654493) Mycobacterium bovis BCG str. Tokyo 172 7561463 YP_002645461.1 CDS subI NC_012207.1 2654490 2655560 R sulfate-binding lipoprotein complement(2654490..2655560) Mycobacterium bovis BCG str. Tokyo 172 7561461 YP_002645462.1 CDS JTY_2410 NC_012207.1 2655574 2655903 D hypothetical protein 2655574..2655903 Mycobacterium bovis BCG str. Tokyo 172 7561812 YP_002645463.1 CDS JTY_2411 NC_012207.1 2655888 2656091 R hypothetical protein complement(2655888..2656091) Mycobacterium bovis BCG str. Tokyo 172 7563010 YP_002645464.1 CDS JTY_2412 NC_012207.1 2656375 2658303 D hypothetical protein 2656375..2658303 Mycobacterium bovis BCG str. Tokyo 172 7563011 YP_002645465.1 CDS lppR NC_012207.1 2658381 2659136 R Differs from Rv2403c by 1aa, L127V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein complement(2658381..2659136) Mycobacterium bovis BCG str. Tokyo 172 7563012 YP_002645466.1 CDS lepA NC_012207.1 2659133 2661094 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(2659133..2661094) Mycobacterium bovis BCG str. Tokyo 172 7560484 YP_002645467.1 CDS JTY_2415 NC_012207.1 2661115 2661684 D hypothetical protein 2661115..2661684 Mycobacterium bovis BCG str. Tokyo 172 7562811 YP_002645468.1 CDS JTY_2416 NC_012207.1 2661855 2662283 R hypothetical protein complement(2661855..2662283) Mycobacterium bovis BCG str. Tokyo 172 7563013 YP_002645469.1 CDS JTY_2417 NC_012207.1 2662543 2663385 D member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2662543..2663385 Mycobacterium bovis BCG str. Tokyo 172 7563014 YP_002645470.1 CDS PE24 NC_012207.1 2663978 2664697 D PE family-related protein 2663978..2664697 Mycobacterium bovis BCG str. Tokyo 172 7563015 YP_002645471.1 CDS JTY_2419 NC_012207.1 2664455 2665294 R hypothetical protein complement(2664455..2665294) Mycobacterium bovis BCG str. Tokyo 172 7561724 YP_002645472.1 CDS JTY_2420 NC_012207.1 2665294 2666271 R hypothetical protein complement(2665294..2666271) Mycobacterium bovis BCG str. Tokyo 172 7563016 YP_002645473.1 CDS JTY_2421 NC_012207.1 2666271 2667926 R hypothetical protein complement(2666271..2667926) Mycobacterium bovis BCG str. Tokyo 172 7563017 YP_002645474.1 CDS rpsT NC_012207.1 2668036 2668296 D binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 2668036..2668296 Mycobacterium bovis BCG str. Tokyo 172 7563018 YP_002645475.1 CDS JTY_2423 NC_012207.1 2668312 2669262 R hypothetical protein complement(2668312..2669262) Mycobacterium bovis BCG str. Tokyo 172 7560749 YP_002645476.1 CDS JTY_2424 NC_012207.1 2669293 2670837 R In Mycobacterium bovis, a single base insertion (*-T) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo (523 aa versus 514 aa); hypothetical protein complement(2669293..2670837) Mycobacterium bovis BCG str. Tokyo 172 7563019 YP_002645477.1 CDS JTY_2425 NC_012207.1 2670852 2671745 R Differs from Rv2415c by 1aa, L291R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2670852..2671745) Mycobacterium bovis BCG str. Tokyo 172 7563840 YP_002645478.1 CDS JTY_2426 NC_012207.1 2672085 2673311 R Differs from Mb2439c by 1aa, T76A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2672085..2673311) Mycobacterium bovis BCG str. Tokyo 172 7563841 YP_002645479.1 CDS JTY_2427 NC_012207.1 2673433 2674275 R hypothetical protein complement(2673433..2674275) Mycobacterium bovis BCG str. Tokyo 172 7563842 YP_002645480.1 CDS JTY_2428 NC_012207.1 2674356 2675099 R hypothetical protein complement(2674356..2675099) Mycobacterium bovis BCG str. Tokyo 172 7563843 YP_002645481.1 CDS JTY_2429 NC_012207.1 2675089 2675760 R Differs from Mb2442c by 1aa, A165V in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; phosphoglycerate mutase complement(2675089..2675760) Mycobacterium bovis BCG str. Tokyo 172 7563844 YP_002645482.1 CDS JTY_2430 NC_012207.1 2675757 2676140 R Differs from Rv2420c and Mb2443c by insertion of 1aa, Pro, at position 126 due to 3bp insertion (GCG) at position equivalent to Mycobacterium bovis 2685985-2685986 in BCG Pasteur and BCG Tokyo; hypothetical protein complement(2675757..2676140) Mycobacterium bovis BCG str. Tokyo 172 7563845 YP_002645483.1 CDS nadD NC_012207.1 2676137 2676772 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(2676137..2676772) Mycobacterium bovis BCG str. Tokyo 172 7563846 YP_002645484.1 CDS JTY_2432 NC_012207.1 2677047 2677319 D hypothetical protein 2677047..2677319 Mycobacterium bovis BCG str. Tokyo 172 7563588 YP_002645485.1 CDS JTY_2433 NC_012207.1 2677561 2678607 D hypothetical protein 2677561..2678607 Mycobacterium bovis BCG str. Tokyo 172 7563847 YP_002645486.1 CDS JTY_2434 NC_012207.1 2678740 2679432 R In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 2bp deletion (GT-*) splits Rv2424c into 2 parts. Differsfrom Rv2424c by 3aa, I172T, A173T and Y192H; transposase complement(2678740..2679432) Mycobacterium bovis BCG str. Tokyo 172 7563848 YP_002645487.1 CDS JTY_2435 NC_012207.1 2679446 2679739 R In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 2bp deletion (GT-*) splits Rv2424c into 2 parts; transposase complement(2679446..2679739) Mycobacterium bovis BCG str. Tokyo 172 7563849 YP_002645488.1 CDS JTY_2436 NC_012207.1 2679828 2681270 R hypothetical protein complement(2679828..2681270) Mycobacterium bovis BCG str. Tokyo 172 7563850 YP_002645489.1 CDS JTY_2437 NC_012207.1 2681270 2682145 R Differs from Rv2426c by 1aa, L113F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2681270..2682145) Mycobacterium bovis BCG str. Tokyo 172 7563851 YP_002645490.1 CDS proA NC_012207.1 2682172 2683419 R Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase complement(2682172..2683419) Mycobacterium bovis BCG str. Tokyo 172 7563852 YP_002645491.1 CDS ahpC NC_012207.1 2684135 2684722 D alkyl hydroperoxide reductase 2684135..2684722 Mycobacterium bovis BCG str. Tokyo 172 7563854 YP_002645492.1 CDS ahpD NC_012207.1 2684748 2685281 D alkyl hydroperoxide reductase 2684748..2685281 Mycobacterium bovis BCG str. Tokyo 172 7563951 YP_002645493.1 CDS PPE41 NC_012207.1 2685278 2685862 R PPE family protein complement(2685278..2685862) Mycobacterium bovis BCG str. Tokyo 172 7563952 YP_002645494.1 CDS PE25 NC_012207.1 2685909 2686208 R PE family protein complement(2685909..2686208) Mycobacterium bovis BCG str. Tokyo 172 7562179 YP_002645495.1 CDS JTY_2445 NC_012207.1 2686379 2686789 R hypothetical protein complement(2686379..2686789) Mycobacterium bovis BCG str. Tokyo 172 7561725 YP_002645496.1 CDS JTY_2446 NC_012207.1 2686786 2687076 R hypothetical protein complement(2686786..2687076) Mycobacterium bovis BCG str. Tokyo 172 7563855 YP_002645497.1 CDS JTY_2447 NC_012207.1 2687057 2688502 R transmembrane protein complement(2687057..2688502) Mycobacterium bovis BCG str. Tokyo 172 7563856 YP_002645498.1 CDS JTY_2448 NC_012207.1 2688499 2690691 R cyclase complement(2688499..2690691) Mycobacterium bovis BCG str. Tokyo 172 7563857 YP_002645499.1 CDS rbsK NC_012207.1 2691172 2692086 D Differs from Rv2436 by 2aa, V274A, A282V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; ribokinase 2691172..2692086 Mycobacterium bovis BCG str. Tokyo 172 7563858 YP_002645500.1 CDS JTY_2450 NC_012207.1 2692318 2692737 D hypothetical protein 2692318..2692737 Mycobacterium bovis BCG str. Tokyo 172 7561552 YP_002645501.1 CDS nadE NC_012207.1 2692734 2694773 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(2692734..2694773) Mycobacterium bovis BCG str. Tokyo 172 7563859 YP_002645502.1 CDS JTY_2452 NC_012207.1 2694651 2694929 D hypothetical protein 2694651..2694929 Mycobacterium bovis BCG str. Tokyo 172 7563589 YP_002645503.1 CDS proB NC_012207.1 2695059 2696189 R catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase complement(2695059..2696189) Mycobacterium bovis BCG str. Tokyo 172 7563860 YP_002645504.1 CDS obgE NC_012207.1 2696189 2697628 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(2696189..2697628) Mycobacterium bovis BCG str. Tokyo 172 7560825 YP_002645505.1 CDS rpmA NC_012207.1 2697714 2697974 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(2697714..2697974) Mycobacterium bovis BCG str. Tokyo 172 7562491 YP_002645506.1 CDS rplU NC_012207.1 2697989 2698303 R 50S ribosomal protein L21 complement(2697989..2698303) Mycobacterium bovis BCG str. Tokyo 172 7560713 YP_002645507.1 CDS dctA NC_012207.1 2698651 2700126 D C4-dicarboxylate-transport transmembrane protein 2698651..2700126 Mycobacterium bovis BCG str. Tokyo 172 7561621 YP_002645508.1 CDS rne NC_012207.1 2700065 2702926 R ribonuclease E complement(2700065..2702926) Mycobacterium bovis BCG str. Tokyo 172 7561471 YP_002645509.1 CDS ndk NC_012207.1 2703256 2703666 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(2703256..2703666) Mycobacterium bovis BCG str. Tokyo 172 7561587 YP_002645510.1 CDS JTY_2460 NC_012207.1 2703709 2704080 R integral membrane protein complement(2703709..2704080) Mycobacterium bovis BCG str. Tokyo 172 7562458 YP_002645511.1 CDS folC NC_012207.1 2704077 2705540 R folylpolyglutamate synthase protein complement(2704077..2705540) Mycobacterium bovis BCG str. Tokyo 172 7563861 YP_002645512.1 CDS valS NC_012207.1 2705537 2708167 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(2705537..2708167) Mycobacterium bovis BCG str. Tokyo 172 7563420 YP_002645513.1 CDS JTY_2463 NC_012207.1 2708255 2709514 R Differs from Rv2449c and Mb2476c by 1aa, C273R in BCG Pasteur and BCG Tokyo; hypothetical protein complement(2708255..2709514) Mycobacterium bovis BCG str. Tokyo 172 7561677 YP_002645514.1 CDS rpfE NC_012207.1 2709525 2710121 R In Mycobacterum bovis BCG Tokyo, 1bp deletion leads to a shortly longer product compared with its homolog in Mycobacterium tuberculosis H37Rv (Rv2450c), Mycobacterium bovis, and BCG Pasteur (198aa vs 172aa), and leads to a product with different C-terminal part.; resuscitation-promoting factor complement(2709525..2710121) Mycobacterium bovis BCG str. Tokyo 172 7563862 YP_002645515.1 CDS JTY_2465 NC_012207.1 2710203 2710601 D Differs from Rv2451 by 1aa, D63N in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 2710203..2710601 Mycobacterium bovis BCG str. Tokyo 172 7561600 YP_002645516.1 CDS JTY_2466 NC_012207.1 2710789 2710935 R hypothetical protein complement(2710789..2710935) Mycobacterium bovis BCG str. Tokyo 172 7563863 YP_002645517.1 CDS mobA NC_012207.1 2710959 2711564 R MobA; links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide; involved in molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein A complement(2710959..2711564) Mycobacterium bovis BCG str. Tokyo 172 7563864 YP_002645518.1 CDS JTY_2468 NC_012207.1 2711566 2712687 R catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin; 2-oxoglutarate ferredoxin oxidoreductase subunit beta complement(2711566..2712687) Mycobacterium bovis BCG str. Tokyo 172 7563535 YP_002645519.1 CDS JTY_2469 NC_012207.1 2712684 2714645 R oxidoreductase subunit alpha complement(2712684..2714645) Mycobacterium bovis BCG str. Tokyo 172 7563865 YP_002645520.1 CDS JTY_2470 NC_012207.1 2714877 2716133 R integral membrane transport protein complement(2714877..2716133) Mycobacterium bovis BCG str. Tokyo 172 7563866 YP_002645521.1 CDS clpX NC_012207.1 2716149 2717429 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(2716149..2717429) Mycobacterium bovis BCG str. Tokyo 172 7563867 YP_002645522.1 CDS mmuM NC_012207.1 2717720 2718628 D converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines; homocysteine methyltransferase 2717720..2718628 Mycobacterium bovis BCG str. Tokyo 172 7562112 YP_002645523.1 CDS JTY_2473 NC_012207.1 2718795 2720321 D Differs from Mb2486 by 1aa, M55I in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; integral membrane transport protein 2718795..2720321 Mycobacterium bovis BCG str. Tokyo 172 7563520 YP_002645524.1 CDS clpP2 NC_012207.1 2720472 2721116 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(2720472..2721116) Mycobacterium bovis BCG str. Tokyo 172 7563868 YP_002645525.1 CDS clpP NC_012207.1 2721113 2721715 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(2721113..2721715) Mycobacterium bovis BCG str. Tokyo 172 7562110 YP_002645526.1 CDS tig NC_012207.1 2721832 2723232 R Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor complement(2721832..2723232) Mycobacterium bovis BCG str. Tokyo 172 7562109 YP_002645527.1 CDS lipP NC_012207.1 2723596 2724780 D esterase/lipase 2723596..2724780 Mycobacterium bovis BCG str. Tokyo 172 7563269 YP_002645528.1 CDS JTY_2478 NC_012207.1 2724800 2725606 R DNA glycosylase complement(2724800..2725606) Mycobacterium bovis BCG str. Tokyo 172 7562843 YP_002645529.1 CDS rpiB NC_012207.1 2725612 2726100 R catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B complement(2725612..2726100) Mycobacterium bovis BCG str. Tokyo 172 7563869 YP_002645530.1 CDS JTY_2480 NC_012207.1 2726202 2726825 R hypothetical protein complement(2726202..2726825) Mycobacterium bovis BCG str. Tokyo 172 7561602 YP_002645531.1 CDS pepN NC_012207.1 2726927 2729512 D Differs from Rv2467 and Mb2494 by 1aa, M18I in Mycobacterium bovis BCG Pasteur.; aminopeptidase N 2726927..2729512 Mycobacterium bovis BCG str. Tokyo 172 7563870 YP_002645532.1 CDS JTY_2482 NC_012207.1 2729585 2730088 R hypothetical protein complement(2729585..2730088) Mycobacterium bovis BCG str. Tokyo 172 7561745 YP_002645533.1 CDS JTY_2483 NC_012207.1 2730308 2730976 R Differs from Rv2469c by 2aa, G28S, S99A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2730308..2730976) Mycobacterium bovis BCG str. Tokyo 172 7563871 YP_002645534.1 CDS glbO NC_012207.1 2731119 2731505 D oxygen-binding protein; globin 2731119..2731505 Mycobacterium bovis BCG str. Tokyo 172 7563872 YP_002645535.1 CDS aglA NC_012207.1 2731505 2733145 D Differs from Rv2471 by 1aa, S206W in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; alpha-glucosidase 2731505..2733145 Mycobacterium bovis BCG str. Tokyo 172 7561917 YP_002645536.1 CDS JTY_2486 NC_012207.1 2733213 2733506 D hypothetical protein 2733213..2733506 Mycobacterium bovis BCG str. Tokyo 172 7563949 YP_002645537.1 CDS JTY_2487 NC_012207.1 2733509 2734225 D alanine and proline rich membrane protein 2733509..2734225 Mycobacterium bovis BCG str. Tokyo 172 7563873 YP_002645538.1 CDS JTY_2488 NC_012207.1 2734257 2734910 R Differs from Mb2501c by 1aa, A30V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2734257..2734910) Mycobacterium bovis BCG str. Tokyo 172 7563874 YP_002645539.1 CDS JTY_2489 NC_012207.1 2734916 2735332 R hypothetical protein complement(2734916..2735332) Mycobacterium bovis BCG str. Tokyo 172 7563875 YP_002645540.1 CDS gdh NC_012207.1 2735329 2740200 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 3 bp deletion (cgg-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1623 aa versus 1624 aa). Differs from Rv2476c by 2aa, loss of A501 due to 3 bp deletion and G1042S; NAD-dependent glutamate dehydrogenase complement(2735329..2740200) Mycobacterium bovis BCG str. Tokyo 172 7563876 YP_002645541.1 CDS JTY_2491 NC_012207.1 2740304 2741980 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein complement(2740304..2741980) Mycobacterium bovis BCG str. Tokyo 172 7561912 YP_002645542.1 CDS JTY_2492 NC_012207.1 2742061 2742546 R hypothetical protein complement(2742061..2742546) Mycobacterium bovis BCG str. Tokyo 172 7563877 YP_002645543.1 CDS JTY_2493 NC_012207.1 2743155 2743478 R hypothetical protein complement(2743155..2743478) Mycobacterium bovis BCG str. Tokyo 172 7563878 YP_002645544.1 CDS plsB2 NC_012207.1 2743494 2745863 R PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase complement(2743494..2745863) Mycobacterium bovis BCG str. Tokyo 172 7563879 YP_002645545.1 CDS plsC NC_012207.1 2745860 2747602 R Differs from Rv2483c by 1aa, G189C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; L-3-phosphoserine phosphatase, 1-acyl-sn-glycerol-3-phosphate acyltransferase; transmembrane phospholipid biosynthesis enzyme complement(2745860..2747602) Mycobacterium bovis BCG str. Tokyo 172 7562129 YP_002645546.1 CDS JTY_2496 NC_012207.1 2747599 2749074 R Differs from Rv2484c by 1aa, D466G in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2747599..2749074) Mycobacterium bovis BCG str. Tokyo 172 7562130 YP_002645547.1 CDS lipQ NC_012207.1 2749303 2750568 R carboxylesterase complement(2749303..2750568) Mycobacterium bovis BCG str. Tokyo 172 7563880 YP_002645548.1 CDS echA14 NC_012207.1 2750930 2751700 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2750930..2751700 Mycobacterium bovis BCG str. Tokyo 172 7563995 YP_002645549.1 CDS PE_PGRS42ab NC_012207.1 2752380 2753963 R In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts, the first due to a single base insertion (*-C) and the second due to a single base deletion (G-*) splits PE_PGRS42 into 3 parts, PE_PGRS42a and PE_PGRS42b and PE_PGRS42d while in Mycobacterium bovis BCG Pasteur and BCG Tokyo, PE_PGRS42a and PE_GRRS42b are fused; PE-PGRS family protein complement(2752380..2753963) Mycobacterium bovis BCG str. Tokyo 172 7562365 YP_002645550.1 CDS JTY_2501 NC_012207.1 2754045 2757458 R Differs from Rv2488c and Mb2515c by 1aa E535D in BCG Pasteur and BCG Tokyo; LuxR-family; transcriptional regulatory protein complement(2754045..2757458) Mycobacterium bovis BCG str. Tokyo 172 7562364 YP_002645551.1 CDS JTY_2502 NC_012207.1 2757424 2757723 R hypothetical alanine rich protein complement(2757424..2757723) Mycobacterium bovis BCG str. Tokyo 172 7563881 YP_002645552.1 CDS PE_PGRS43b NC_012207.1 2757960 2761286 R In Mycobacterium tuberculosis strain H37Rv, PE_PGRS43 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 8 bp insertion (*-GGGGGGGG ) splits PE_PGRS43 into 2 parts, PE_PGRS43a and PE_PGRS43b while in Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 1bp insertion (equivalent to Mycobacterium tuberculosis H37Rv position 2804942-2804943) causes a different frameshift but at same place, 3bp:GCC deletion in BCG Pasteur after 2409:G of Mycobacterium bovis, 1bp:T deletion in BCG Tokyo at 2931:T of Mycobacterium bovis.; PE-PGRS family protein complement(2757960..2761286) Mycobacterium bovis BCG str. Tokyo 172 7563882 YP_002645553.1 CDS PE_PGRS43a NC_012207.1 2761378 2762805 R In Mycobacterium tuberculosis strain H37Rv, PE_PGRS43 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 8 bp insertion (*-GGGGGGGG ) splits PE_PGRS43 into 2 parts, PE_PGRS43a and PE_PGRS43b while in Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 1 bp insertion (equivalent to Mycobacterium tuberculosis H37Rv position 2804942-2804943) causes a different frameshift but at same place, 3bp:GCC deletion in BCG Pasteur after 2409:G of Mycobacterium bovis, 1bp:T deletion in BCG Tokyo at 2931:T of Mycobacterium bovis.; PE-PGRS family protein complement(2761378..2762805) Mycobacterium bovis BCG str. Tokyo 172 7562367 YP_002645554.1 CDS JTY_2505 NC_012207.1 2763234 2763857 D hypothetical protein 2763234..2763857 Mycobacterium bovis BCG str. Tokyo 172 7562366 YP_002645555.1 CDS JTY_2506 NC_012207.1 2763847 2764599 D Differs from Rv2492 by 1aa, D70A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein 2763847..2764599 Mycobacterium bovis BCG str. Tokyo 172 7563883 YP_002645556.1 CDS JTY_2507 NC_012207.1 2764652 2764873 D hypothetical protein 2764652..2764873 Mycobacterium bovis BCG str. Tokyo 172 7563884 YP_002645557.1 CDS JTY_2508 NC_012207.1 2764879 2765304 D hypothetical protein 2764879..2765304 Mycobacterium bovis BCG str. Tokyo 172 7563885 YP_002645558.1 CDS pdhC NC_012207.1 2765327 2766508 R Differs from Rv2495c by 2aa, A107T, W208R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; branched-chain alpha-keto acid dehydrogenase subunit E2 complement(2765327..2766508) Mycobacterium bovis BCG str. Tokyo 172 7563886 YP_002645559.1 CDS pdhB NC_012207.1 2766505 2767551 R Differs from Rv2496c by 1aa, S201G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; pyruvate dehydrogenase E1 component subunit beta complement(2766505..2767551) Mycobacterium bovis BCG str. Tokyo 172 7561707 YP_002645560.1 CDS pdhA NC_012207.1 2767562 2768665 R pyruvate dehydrogenase E1 component subunit alpha complement(2767562..2768665) Mycobacterium bovis BCG str. Tokyo 172 7561450 YP_002645561.1 CDS citE NC_012207.1 2768924 2769745 R citrate (pro-3s)-lyase subunit beta complement(2768924..2769745) Mycobacterium bovis BCG str. Tokyo 172 7562527 YP_002645562.1 CDS JTY_2513 NC_012207.1 2769742 2770299 R oxidase regulatory-related protein complement(2769742..2770299) Mycobacterium bovis BCG str. Tokyo 172 7562106 YP_002645563.1 CDS fadE19 NC_012207.1 2770296 2771480 R acyl-CoA dehydrogenase complement(2770296..2771480) Mycobacterium bovis BCG str. Tokyo 172 7563887 YP_002645564.1 CDS accA1 NC_012207.1 2771485 2773449 R acetyl-/propionyl-coenzyme A carboxylase alpha chain subunit alpha complement(2771485..2773449) Mycobacterium bovis BCG str. Tokyo 172 7563367 YP_002645565.1 CDS accD1 NC_012207.1 2773454 2775043 R Differs from Rv2502c by 2aa, S77G, L343F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acetyl-/propionyl-coa carboxylase subunit beta complement(2773454..2775043) Mycobacterium bovis BCG str. Tokyo 172 7564329 YP_002645566.1 CDS scoB NC_012207.1 2775040 2775696 R succinyl-CoA:3-ketoacid-coenzyme A transferase subunit beta complement(2775040..2775696) Mycobacterium bovis BCG str. Tokyo 172 7564332 YP_002645567.1 CDS scoA NC_012207.1 2775693 2776439 R succinyl-CoA:3-ketoacid-coenzyme A transferase subunit alpha complement(2775693..2776439) Mycobacterium bovis BCG str. Tokyo 172 7560759 YP_002645568.1 CDS fadD35 NC_012207.1 2776522 2778165 R Differs from Rv2505c and Mb2533c by 1aa, A381T in BCG Pasteur and BCG Tokyo; AMP-binding protein complement(2776522..2778165) Mycobacterium bovis BCG str. Tokyo 172 7560758 YP_002645569.1 CDS JTY_2520 NC_012207.1 2778281 2778928 D probably TetR-family; transcriptional regulatory protein 2778281..2778928 Mycobacterium bovis BCG str. Tokyo 172 7563351 YP_002645570.1 CDS JTY_2521 NC_012207.1 2779007 2779828 D proline rich membrane protein 2779007..2779828 Mycobacterium bovis BCG str. Tokyo 172 7563888 YP_002645571.1 CDS JTY_2522 NC_012207.1 2779825 2781162 R integral membrane leucine and alanine rich protein complement(2779825..2781162) Mycobacterium bovis BCG str. Tokyo 172 7563889 YP_002645572.1 CDS JTY_2523 NC_012207.1 2781247 2782053 D short-chain type dehydrogenase/reductase 2781247..2782053 Mycobacterium bovis BCG str. Tokyo 172 7563890 YP_002645573.1 CDS JTY_2524 NC_012207.1 2782057 2783658 R hypothetical protein complement(2782057..2783658) Mycobacterium bovis BCG str. Tokyo 172 7563891 YP_002645574.1 CDS orn NC_012207.1 2783726 2784373 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 2783726..2784373 Mycobacterium bovis BCG str. Tokyo 172 7563892 YP_002645575.1 CDS JTY_2526 NC_012207.1 2785125 2786372 R transposase for insertion sequence element IS1081 complement(2785125..2786372) Mycobacterium bovis BCG str. Tokyo 172 7563319 YP_002645576.1 CDS JTY_2527 NC_012207.1 2786372 2786509 D hypothetical protein 2786372..2786509 Mycobacterium bovis BCG str. Tokyo 172 7563893 YP_002645577.1 CDS JTY_2528 NC_012207.1 2786730 2787152 D Differs from Rv2513 by 1aa, K122T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2786730..2787152 Mycobacterium bovis BCG str. Tokyo 172 7563894 YP_002645578.1 CDS JTY_2529 NC_012207.1 2787446 2787907 R hypothetical protein complement(2787446..2787907) Mycobacterium bovis BCG str. Tokyo 172 7563895 YP_002645579.1 CDS JTY_2530 NC_012207.1 2787913 2789160 R hypothetical protein complement(2787913..2789160) Mycobacterium bovis BCG str. Tokyo 172 7563896 YP_002645580.1 CDS JTY_2531 NC_012207.1 2789279 2790082 R hypothetical protein complement(2789279..2790082) Mycobacterium bovis BCG str. Tokyo 172 7563897 YP_002645581.1 CDS JTY_2532 NC_012207.1 2790079 2790330 R hypothetical protein complement(2790079..2790330) Mycobacterium bovis BCG str. Tokyo 172 7563898 YP_002645582.1 CDS lppS NC_012207.1 2790678 2791904 R lipoprotein complement(2790678..2791904) Mycobacterium bovis BCG str. Tokyo 172 7563899 YP_002645583.1 CDS PE26 NC_012207.1 2792354 2793832 D Identical to Rv2519 but differs from Mb2548 by 1aa, G173A, due to 2bp substitution at position equivalent to Mycobacterium bovis 2803099-2803100 CC-GG in BCG Pasteur and BCG Tokyo.; PE family protein 2792354..2793832 Mycobacterium bovis BCG str. Tokyo 172 7560544 YP_002645584.1 CDS JTY_2535 NC_012207.1 2793957 2794184 R hypothetical protein complement(2793957..2794184) Mycobacterium bovis BCG str. Tokyo 172 7561726 YP_002645585.1 CDS bcp NC_012207.1 2794253 2794726 D Differs from Mb2550 by 1aa, V122M in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; bacterioferritin comigratory protein 2794253..2794726 Mycobacterium bovis BCG str. Tokyo 172 7563900 YP_002645586.1 CDS JTY_2537 NC_012207.1 2794698 2796110 R hypothetical protein complement(2794698..2796110) Mycobacterium bovis BCG str. Tokyo 172 7562060 YP_002645587.1 CDS acpS NC_012207.1 2796107 2796499 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(2796107..2796499) Mycobacterium bovis BCG str. Tokyo 172 7563901 YP_002645588.1 CDS fas NC_012207.1 2796692 2805901 R fatty acid synthase complement(2796692..2805901) Mycobacterium bovis BCG str. Tokyo 172 7563933 YP_002645589.1 CDS JTY_2540 NC_012207.1 2806421 2807143 R hypothetical protein complement(2806421..2807143) Mycobacterium bovis BCG str. Tokyo 172 7563395 YP_002645590.1 CDS JTY_2541 NC_012207.1 2807660 2807887 D hypothetical protein 2807660..2807887 Mycobacterium bovis BCG str. Tokyo 172 7563902 YP_002645591.1 CDS JTY_2542 NC_012207.1 2807884 2808285 D hypothetical protein 2807884..2808285 Mycobacterium bovis BCG str. Tokyo 172 7563903 YP_002645592.1 CDS mrr NC_012207.1 2808320 2809240 R Differs from Rv2528c by 1aa, L94P, and Mb2557c by 2aa, L94P, E259Q in BCG Pasteur and BCG Tokyo; restriction system protein complement(2808320..2809240) Mycobacterium bovis BCG str. Tokyo 172 7563904 YP_002645593.1 CDS JTY_2544 NC_012207.1 2809444 2810835 D Differs from Mb2558 by 1aa, G94E in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2809444..2810835 Mycobacterium bovis BCG str. Tokyo 172 7563561 YP_002645594.1 CDS JTY_2545 NC_012207.1 2810836 2811255 R hypothetical protein complement(2810836..2811255) Mycobacterium bovis BCG str. Tokyo 172 7563905 YP_002645595.1 CDS JTY_2546 NC_012207.1 2811252 2811476 R hypothetical protein complement(2811252..2811476) Mycobacterium bovis BCG str. Tokyo 172 7563906 YP_002645596.1 CDS JTY_2547 NC_012207.1 2811507 2814350 R amino acid decarboxylase complement(2811507..2814350) Mycobacterium bovis BCG str. Tokyo 172 7563907 YP_002645597.1 CDS JTY_2548 NC_012207.1 2814422 2814823 R hypothetical protein complement(2814422..2814823) Mycobacterium bovis BCG str. Tokyo 172 7563908 YP_002645598.1 CDS nusB NC_012207.1 2814823 2815293 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(2814823..2815293) Mycobacterium bovis BCG str. Tokyo 172 7563909 YP_002645599.1 CDS efp NC_012207.1 2815296 2815859 R Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P complement(2815296..2815859) Mycobacterium bovis BCG str. Tokyo 172 7562489 YP_002645600.1 CDS pepQ NC_012207.1 2815869 2816987 R cytoplasmic peptidase complement(2815869..2816987) Mycobacterium bovis BCG str. Tokyo 172 7561541 YP_002645601.1 CDS JTY_2552 NC_012207.1 2817021 2817713 D transmembrane protein 2817021..2817713 Mycobacterium bovis BCG str. Tokyo 172 7561746 YP_002645602.1 CDS aroD NC_012207.1 2817717 2818160 R catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase complement(2817717..2818160) Mycobacterium bovis BCG str. Tokyo 172 7563910 YP_002645603.1 CDS aroB NC_012207.1 2818157 2819245 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(2818157..2819245) Mycobacterium bovis BCG str. Tokyo 172 7563998 YP_002645604.1 CDS aroK NC_012207.1 2819242 2819772 R catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase complement(2819242..2819772) Mycobacterium bovis BCG str. Tokyo 172 7563997 YP_002645605.1 CDS aroF NC_012207.1 2819776 2820981 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(2819776..2820981) Mycobacterium bovis BCG str. Tokyo 172 7564002 YP_002645606.1 CDS JTY_2557 NC_012207.1 2820996 2821403 D hypothetical alanine rich protein 2820996..2821403 Mycobacterium bovis BCG str. Tokyo 172 7564000 YP_002645607.1 CDS JTY_2558 NC_012207.1 2821699 2822910 D Differs from Rv2542 by 1aa, A211T in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 2821699..2822910 Mycobacterium bovis BCG str. Tokyo 172 7563911 YP_002645608.1 CDS lppA NC_012207.1 2823037 2823696 D lipoprotein 2823037..2823696 Mycobacterium bovis BCG str. Tokyo 172 7563912 YP_002645609.1 CDS lprR NC_012207.1 2823693 2824352 D In Mycobacterium bovis, Mycobacterium bovisBCG Pasteur, and BCG Tokyo, there is a 656 bp insertion, relative to Mycobacterium tuberculosis strain H37Rv, which leads to lppR gene, probably by duplication of llpA or lppB; lipoprotein 2823693..2824352 Mycobacterium bovis BCG str. Tokyo 172 7560466 YP_002645610.1 CDS lppB NC_012207.1 2824349 2825011 D lipoprotein 2824349..2825011 Mycobacterium bovis BCG str. Tokyo 172 7560535 YP_002645611.1 CDS JTY_2562 NC_012207.1 2825008 2825286 D hypothetical protein 2825008..2825286 Mycobacterium bovis BCG str. Tokyo 172 7560467 YP_002645612.1 CDS JTY_2563 NC_012207.1 2825379 2825792 D hypothetical protein 2825379..2825792 Mycobacterium bovis BCG str. Tokyo 172 7563913 YP_002645613.1 CDS JTY_2564 NC_012207.1 2825831 2826088 D hypothetical protein 2825831..2826088 Mycobacterium bovis BCG str. Tokyo 172 7563914 YP_002645614.1 CDS JTY_2565 NC_012207.1 2826085 2826462 D hypothetical protein 2826085..2826462 Mycobacterium bovis BCG str. Tokyo 172 7563915 YP_002645615.1 CDS JTY_2566 NC_012207.1 2826952 2827347 R hypothetical protein complement(2826952..2827347) Mycobacterium bovis BCG str. Tokyo 172 7563916 YP_002645616.1 CDS JTY_2567 NC_012207.1 2827344 2827589 R hypothetical protein complement(2827344..2827589) Mycobacterium bovis BCG str. Tokyo 172 7563917 YP_002645617.1 CDS JTY_2568 NC_012207.1 2828000 2828419 R hypothetical protein complement(2828000..2828419) Mycobacterium bovis BCG str. Tokyo 172 7563918 YP_002645618.1 CDS aroE NC_012207.1 2828431 2829213 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(2828431..2829213) Mycobacterium bovis BCG str. Tokyo 172 7563919 YP_002645619.1 CDS JTY_2570 NC_012207.1 2829236 2830489 R hypothetical protein complement(2829236..2830489) Mycobacterium bovis BCG str. Tokyo 172 7563999 YP_002645620.1 CDS JTY_2571 NC_012207.1 2830482 2830994 R similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein complement(2830482..2830994) Mycobacterium bovis BCG str. Tokyo 172 7563920 YP_002645621.1 CDS alaS NC_012207.1 2830995 2833709 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(2830995..2833709) Mycobacterium bovis BCG str. Tokyo 172 7563921 YP_002645622.1 CDS JTY_2573 NC_012207.1 2833800 2834189 R hypothetical protein complement(2833800..2834189) Mycobacterium bovis BCG str. Tokyo 172 7563954 YP_002645623.1 CDS JTY_2574 NC_012207.1 2834296 2834970 D hypothetical protein 2834296..2834970 Mycobacterium bovis BCG str. Tokyo 172 7561368 YP_002645624.1 CDS JTY_2575 NC_012207.1 2835055 2835765 D hypothetical protein 2835055..2835765 Mycobacterium bovis BCG str. Tokyo 172 7561369 YP_002645625.1 CDS JTY_2576 NC_012207.1 2835795 2837153 R Differs from Rv2559c by 1aa, D317G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; recombination factor protein RarA complement(2835795..2837153) Mycobacterium bovis BCG str. Tokyo 172 7561370 YP_002645626.1 CDS JTY_2577 NC_012207.1 2837299 2838276 D Differs from Rv2560 by 1aa, L210V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; proline and glycine rich transmembrane protein 2837299..2838276 Mycobacterium bovis BCG str. Tokyo 172 7561371 YP_002645627.1 CDS JTY_2578 NC_012207.1 2838633 2839370 D In Mycobacterium tuberculosis strain H37Rv, Rv2561 and Rv2562 exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base deletion(g-*) results in a single product which is more similar to Rv2561; hypothetical protein 2838633..2839370 Mycobacterium bovis BCG str. Tokyo 172 7561372 YP_002645628.1 CDS JTY_2579 NC_012207.1 2839513 2840562 D glutamine-transport transmembrane protein ABC transporter 2839513..2840562 Mycobacterium bovis BCG str. Tokyo 172 7561373 YP_002645629.1 CDS glnQ NC_012207.1 2840565 2841557 D glutamine-transport ATP-binding protein ABC transporter 2840565..2841557 Mycobacterium bovis BCG str. Tokyo 172 7561374 YP_002645630.1 CDS JTY_2581 NC_012207.1 2841834 2843585 D hypothetical protein 2841834..2843585 Mycobacterium bovis BCG str. Tokyo 172 7561934 YP_002645631.1 CDS JTY_2582 NC_012207.1 2843596 2845197 D In Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 2bp deletion (GC-*) splits Rv2566 into 2 parts. Differs from first part of Rv2566 by 3aa, S10G, S270A, L315V and from Mb2595 by 1aa, L315V in BCG Pasteur and BCG Tokyo; hypothetical protein 2843596..2845197 Mycobacterium bovis BCG str. Tokyo 172 7561375 YP_002645632.1 CDS JTY_2583 NC_012207.1 2845223 2847016 D In Mycobacterium tuberculosis strain H37Rv, Rv2566 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a 2bp deletion (GC-*) splits Rv2566 into 2 parts. Differs from Rv2566 by 2aa, P67L, E326G, and from Mb2596 by 1aa, E326G in BCG Pasteur and BCG Tokyo; hypothetical protein 2845223..2847016 Mycobacterium bovis BCG str. Tokyo 172 7561376 YP_002645633.1 CDS JTY_2584 NC_012207.1 2847016 2849670 D Differs from Rv2567 by 1aa, R645Q in BCG Pasteur and BCG Tokyo; hypothetical alanine and leucine rich protein 2847016..2849670 Mycobacterium bovis BCG str. Tokyo 172 7561377 YP_002645634.1 CDS JTY_2585 NC_012207.1 2849667 2850692 R hypothetical protein complement(2849667..2850692) Mycobacterium bovis BCG str. Tokyo 172 7561378 YP_002645635.1 CDS JTY_2586 NC_012207.1 2850685 2851629 R hypothetical protein complement(2850685..2851629) Mycobacterium bovis BCG str. Tokyo 172 7561379 YP_002645636.1 CDS JTY_2587 NC_012207.1 2851733 2852122 D hypothetical protein 2851733..2852122 Mycobacterium bovis BCG str. Tokyo 172 7561380 YP_002645637.1 CDS JTY_2588 NC_012207.1 2852114 2853181 R Differs from Rv2571c and Mb2601c by 1aa, C68R in Mycobacterium bovis BCG Pasteur.; transmembrane alanine and valine and leucine rich protein complement(2852114..2853181) Mycobacterium bovis BCG str. Tokyo 172 7561381 YP_002645638.1 CDS aspS NC_012207.1 2853188 2855023 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(2853188..2855023) Mycobacterium bovis BCG str. Tokyo 172 7561382 YP_002645639.1 CDS JTY_2590 NC_012207.1 2855263 2856003 D 2-dehydropantoate 2-reductase 2855263..2856003 Mycobacterium bovis BCG str. Tokyo 172 7562045 YP_002645640.1 CDS JTY_2591 NC_012207.1 2856026 2856529 D hypothetical protein 2856026..2856529 Mycobacterium bovis BCG str. Tokyo 172 7561383 YP_002645641.1 CDS JTY_2592 NC_012207.1 2856559 2857440 D membrane glycine rich protein 2856559..2857440 Mycobacterium bovis BCG str. Tokyo 172 7561384 YP_002645642.1 CDS JTY_2593 NC_012207.1 2857446 2857910 R hypothetical protein complement(2857446..2857910) Mycobacterium bovis BCG str. Tokyo 172 7561385 YP_002645643.1 CDS JTY_2594 NC_012207.1 2858138 2859727 D In Mycobacterium tuberculosis strain H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, Rv2577 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base transition (G-A) splits Rv2577 into 2 parts, Mb2607 and Mb2608; hypothetical protein 2858138..2859727 Mycobacterium bovis BCG str. Tokyo 172 7561386 YP_002645644.1 CDS JTY_2595 NC_012207.1 2859729 2860751 R hypothetical protein complement(2859729..2860751) Mycobacterium bovis BCG str. Tokyo 172 7561387 YP_002645645.1 CDS dhaA NC_012207.1 2860859 2861761 D catalyzes the cleavage of carbon-halogen bonds in aliphatic compounds forming a primary alcohol and a halide; haloalkane dehalogenase 2860859..2861761 Mycobacterium bovis BCG str. Tokyo 172 7561388 YP_002645646.1 CDS hisS NC_012207.1 2862041 2863312 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(2862041..2863312) Mycobacterium bovis BCG str. Tokyo 172 7561492 YP_002645647.1 CDS JTY_2598 NC_012207.1 2863309 2863983 R glyoxalase II complement(2863309..2863983) Mycobacterium bovis BCG str. Tokyo 172 7563318 YP_002645648.1 CDS ppiB NC_012207.1 2864034 2864960 D Differs from Rv2582 by 1aa, F66V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; peptidyl-prolyl cis-trans isomerase B 2864034..2864960 Mycobacterium bovis BCG str. Tokyo 172 7561389 YP_002645649.1 CDS relA NC_012207.1 2865046 2867418 R GTP pyrophosphokinase complement(2865046..2867418) Mycobacterium bovis BCG str. Tokyo 172 7560807 YP_002645650.1 CDS apt NC_012207.1 2867449 2868120 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(2867449..2868120) Mycobacterium bovis BCG str. Tokyo 172 7561565 YP_002645651.1 CDS JTY_2602 NC_012207.1 2868224 2869897 R Differs from Rv2585c by 1aa, S462C; lipoprotein complement(2868224..2869897) Mycobacterium bovis BCG str. Tokyo 172 7563981 YP_002645652.1 CDS secF NC_012207.1 2869903 2871231 R forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF complement(2869903..2871231) Mycobacterium bovis BCG str. Tokyo 172 7561390 YP_002645653.1 CDS secD NC_012207.1 2871235 2872956 R part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD complement(2871235..2872956) Mycobacterium bovis BCG str. Tokyo 172 7560775 YP_002645654.1 CDS yajC NC_012207.1 2873066 2873413 R member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC complement(2873066..2873413) Mycobacterium bovis BCG str. Tokyo 172 7560772 YP_002645655.1 CDS gabT NC_012207.1 2873580 2874929 D catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 2873580..2874929 Mycobacterium bovis BCG str. Tokyo 172 7561702 YP_002645656.1 CDS fadD9 NC_012207.1 2875091 2878597 D Differs from Rv2590 by 1aa, Y309F, and from Mb2621 by 1aa, A1106T in BCG Pasteur and BCG Tokyo; fatty-acid-CoA ligase 2875091..2878597 Mycobacterium bovis BCG str. Tokyo 172 7561894 YP_002645657.1 CDS PE_PGRS44 NC_012207.1 2878771 2880411 D Differs from Rv2591 by extra 3 aa resulting from same 9 bp in-frame insertion as in Mycobacterium bovis(*-GGCGGCACC) and by 2aa S415G, D463G in BCG Pasteur and BCG Tokyo; PE-PGRS family protein 2878771..2880411 Mycobacterium bovis BCG str. Tokyo 172 7563357 YP_002645658.1 CDS ruvB NC_012207.1 2880428 2881462 R promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB complement(2880428..2881462) Mycobacterium bovis BCG str. Tokyo 172 7562368 YP_002645659.1 CDS ruvA NC_012207.1 2881459 2882049 R plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA complement(2881459..2882049) Mycobacterium bovis BCG str. Tokyo 172 7560752 YP_002645660.1 CDS ruvC NC_012207.1 2882046 2882612 R endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase complement(2882046..2882612) Mycobacterium bovis BCG str. Tokyo 172 7560751 YP_002645661.1 CDS JTY_2612 NC_012207.1 2882721 2882966 D hypothetical protein 2882721..2882966 Mycobacterium bovis BCG str. Tokyo 172 7560753 YP_002645662.1 CDS JTY_2613 NC_012207.1 2882963 2883367 D Differs from Rv2596 by 1aa, R77C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2882963..2883367 Mycobacterium bovis BCG str. Tokyo 172 7561391 YP_002645663.1 CDS JTY_2614 NC_012207.1 2883584 2884204 D hypothetical protein 2883584..2884204 Mycobacterium bovis BCG str. Tokyo 172 7561392 YP_002645664.1 CDS JTY_2615 NC_012207.1 2884215 2884709 D hypothetical protein 2884215..2884709 Mycobacterium bovis BCG str. Tokyo 172 7561393 YP_002645665.1 CDS JTY_2616 NC_012207.1 2884706 2885137 D Differs from Rv2599 by 1aa, I12S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2884706..2885137 Mycobacterium bovis BCG str. Tokyo 172 7561394 YP_002645666.1 CDS JTY_2617 NC_012207.1 2885219 2885425 D First 64 aa identical to N-terminal part of Rv2600 and Mb2631 but then frameshifts due to 10bp deletion at position equivalent to Mycobacterium bovis coordinates 2895640-2895649. Results in BCG Pasteur and BCG Tokyo orthologs of Mb2631 and Rv2600 being in two parts; integral membrane protein 2885219..2885425 Mycobacterium bovis BCG str. Tokyo 172 7561395 YP_002645667.1 CDS JTY_2618 NC_012207.1 2885431 2885610 D All 59aa are identical to C-terminal part of Rv2600 and Mb2631 owing to frameshifts due to 10bp deletion at position equivalent to Mycobacterium bovis coordinates 2895640-2895649. Results in BCG Pasteur and BCG Tokyo orthologs of Mb2631 and Rv2600 being in two parts, both of which encode hydrophobic proteins; integral membrane protein 2885431..2885610 Mycobacterium bovis BCG str. Tokyo 172 7561396 YP_002645668.1 CDS speE NC_012207.1 2885607 2887178 D catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 2885607..2887178 Mycobacterium bovis BCG str. Tokyo 172 7561397 YP_002645669.1 CDS JTY_2620 NC_012207.1 2887289 2887576 D hypothetical protein 2887289..2887576 Mycobacterium bovis BCG str. Tokyo 172 7561804 YP_002645670.1 CDS JTY_2621 NC_012207.1 2887563 2888003 D hypothetical protein 2887563..2888003 Mycobacterium bovis BCG str. Tokyo 172 7561398 YP_002645671.1 CDS JTY_2622 NC_012207.1 2888024 2888779 R hypothetical protein complement(2888024..2888779) Mycobacterium bovis BCG str. Tokyo 172 7561399 YP_002645672.1 CDS JTY_2623 NC_012207.1 2888912 2889508 R with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT complement(2888912..2889508) Mycobacterium bovis BCG str. Tokyo 172 7561400 YP_002645673.1 CDS tesB2 NC_012207.1 2889516 2890361 R Differs from Rv2605c by 1aa, L85F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acyl-CoA thioesterase II complement(2889516..2890361) Mycobacterium bovis BCG str. Tokyo 172 7561401 YP_002645674.1 CDS JTY_2625 NC_012207.1 2890390 2891289 R with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS complement(2890390..2891289) Mycobacterium bovis BCG str. Tokyo 172 7561841 YP_002645675.1 CDS pdxH NC_012207.1 2891417 2892091 D catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 2891417..2892091 Mycobacterium bovis BCG str. Tokyo 172 7561402 YP_002645676.1 CDS PPE42 NC_012207.1 2892265 2894007 D Differs from Rv2608 by 1aa, S281P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PPE family protein 2892265..2894007 Mycobacterium bovis BCG str. Tokyo 172 7561708 YP_002645677.1 CDS JTY_2628 NC_012207.1 2894029 2895084 R hypothetical protein complement(2894029..2895084) Mycobacterium bovis BCG str. Tokyo 172 7562180 YP_002645678.1 CDS pimA NC_012207.1 2895084 2896220 R alpha-mannosyltransferase complement(2895084..2896220) Mycobacterium bovis BCG str. Tokyo 172 7561403 YP_002645679.1 CDS JTY_2630 NC_012207.1 2896231 2897181 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(2896231..2897181) Mycobacterium bovis BCG str. Tokyo 172 7562421 YP_002645680.1 CDS pgsA1 NC_012207.1 2897178 2897831 R phosphatidylinositol synthase complement(2897178..2897831) Mycobacterium bovis BCG str. Tokyo 172 7561404 YP_002645681.1 CDS JTY_2632 NC_012207.1 2897828 2898415 R hypothetical protein complement(2897828..2898415) Mycobacterium bovis BCG str. Tokyo 172 7562401 YP_002645682.1 CDS thrS NC_012207.1 2898408 2900486 R catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase complement(2898408..2900486) Mycobacterium bovis BCG str. Tokyo 172 7561405 YP_002645683.1 CDS JTY_2634 NC_012207.1 2900595 2900822 D Differs from Mb2647 by 1aa, R57H in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; hypothetical protein 2900595..2900822 Mycobacterium bovis BCG str. Tokyo 172 7561853 YP_002645684.1 CDS PE_PGRS45b NC_012207.1 2900819 2901988 R In Mycobacterium bovis, a 9 bp in-frame insertion (*-CCGCCGTTT) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 461 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 7bp deletion at position corresponding to M. bovis 2944835-2944841 splits PE_PGRS45 in two parts; PE-PGRS family protein complement(2900819..2901988) Mycobacterium bovis BCG str. Tokyo 172 7561406 YP_002645685.1 CDS PE_PGRS45a NC_012207.1 2901976 2902206 R In Mycobacterium bovis, a 9 bp in-frame insertion (*-CCGCCGTTT) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (464 aa versus 461 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a 7bp deletion at position corresponding to M. bovis 2944835-2944841 splits PE_PGRS45 in two parts. Differs from Rv2615c by 1aa, V40A in BCG Pasteur and BCG Tokyo; PE-PGRS family protein complement(2901976..2902206) Mycobacterium bovis BCG str. Tokyo 172 7562370 YP_002645686.1 CDS JTY_2637 NC_012207.1 2902551 2903051 D Differs from Rv2616 by 1aa, I72V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2902551..2903051 Mycobacterium bovis BCG str. Tokyo 172 7562369 YP_002645687.1 CDS JTY_2638 NC_012207.1 2903068 2903508 R transmembrane protein complement(2903068..2903508) Mycobacterium bovis BCG str. Tokyo 172 7561407 YP_002645688.1 CDS JTY_2639 NC_012207.1 2903655 2904332 D hypothetical protein 2903655..2904332 Mycobacterium bovis BCG str. Tokyo 172 7561408 YP_002645689.1 CDS JTY_2640 NC_012207.1 2904317 2904670 R hypothetical protein complement(2904317..2904670) Mycobacterium bovis BCG str. Tokyo 172 7561409 YP_002645690.1 CDS JTY_2641 NC_012207.1 2904683 2905108 R transmembrane protein complement(2904683..2905108) Mycobacterium bovis BCG str. Tokyo 172 7561410 YP_002645691.1 CDS JTY_2642 NC_012207.1 2905105 2905776 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 3 bp deletion (GGG-*) leads to a slightly shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (223 aa versus 224 aa) due to deletion of 1aa after position 194; transcriptional regulatory protein complement(2905105..2905776) Mycobacterium bovis BCG str. Tokyo 172 7561411 YP_002645692.1 CDS JTY_2643 NC_012207.1 2905854 2906675 D methyltransferase 2905854..2906675 Mycobacterium bovis BCG str. Tokyo 172 7561412 YP_002645693.1 CDS TB31.7 NC_012207.1 2906811 2907704 D hypothetical protein 2906811..2907704 Mycobacterium bovis BCG str. Tokyo 172 7561413 YP_002645694.1 CDS JTY_2645 NC_012207.1 2907707 2908525 R hypothetical protein complement(2907707..2908525) Mycobacterium bovis BCG str. Tokyo 172 7561834 YP_002645695.1 CDS JTY_2646 NC_012207.1 2908540 2909721 R transmembrane alanine and leucine rich protein complement(2908540..2909721) Mycobacterium bovis BCG str. Tokyo 172 7561414 YP_002645696.1 CDS JTY_2647 NC_012207.1 2909780 2910211 R hypothetical protein complement(2909780..2910211) Mycobacterium bovis BCG str. Tokyo 172 7561415 YP_002645697.1 CDS JTY_2648 NC_012207.1 2910725 2911966 R Differs from Rv2627c by 1aa, G104R in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2910725..2911966) Mycobacterium bovis BCG str. Tokyo 172 7561416 YP_002645698.1 CDS JTY_2649 NC_012207.1 2912276 2912638 D Differs from Rv2628 by 1aa, L59S, and from Mb2661 by 1aa, P68R in BCG Pasteur and BCG Tokyo; hypothetical protein 2912276..2912638 Mycobacterium bovis BCG str. Tokyo 172 7561417 YP_002645699.1 CDS JTY_2650 NC_012207.1 2912985 2914109 D hypothetical protein 2912985..2914109 Mycobacterium bovis BCG str. Tokyo 172 7561418 YP_002645700.1 CDS JTY_2651 NC_012207.1 2914111 2914650 D hypothetical protein 2914111..2914650 Mycobacterium bovis BCG str. Tokyo 172 7561419 YP_002645701.1 CDS JTY_2652 NC_012207.1 2914789 2916087 D hypothetical protein 2914789..2916087 Mycobacterium bovis BCG str. Tokyo 172 7561420 YP_002645702.1 CDS JTY_2653 NC_012207.1 2916126 2916407 R hypothetical protein complement(2916126..2916407) Mycobacterium bovis BCG str. Tokyo 172 7561421 YP_002645703.1 CDS JTY_2654 NC_012207.1 2916552 2917037 R hypothetical protein complement(2916552..2917037) Mycobacterium bovis BCG str. Tokyo 172 7561422 YP_002645704.1 CDS PE_PGRS46 NC_012207.1 2917322 2919724 R In Mycobacterium bovis BCG Pasteur, an in-frame insertion of 66 bp, leads to a longer product compared to Mycobacterium bovis and Mycobacterium tuberculosis strain H37Rv (800 aa versus 778 aa); PE-PGRS family protein complement(2917322..2919724) Mycobacterium bovis BCG str. Tokyo 172 7561423 YP_002645705.1 CDS JTY_2656 NC_012207.1 2919753 2919995 D hypothetical protein 2919753..2919995 Mycobacterium bovis BCG str. Tokyo 172 7562371 YP_002645706.1 CDS JTY_2657 NC_012207.1 2919996 2920673 D hypothetical protein 2919996..2920673 Mycobacterium bovis BCG str. Tokyo 172 7561424 YP_002645707.1 CDS dedA NC_012207.1 2920869 2921525 D transmembrane protein 2920869..2921525 Mycobacterium bovis BCG str. Tokyo 172 7561425 YP_002645708.1 CDS JTY_2659 NC_012207.1 2921688 2922134 D hypothetical protein 2921688..2922134 Mycobacterium bovis BCG str. Tokyo 172 7561474 YP_002645709.1 CDS JTY_2660 NC_012207.1 2922309 2922641 R hypothetical protein complement(2922309..2922641) Mycobacterium bovis BCG str. Tokyo 172 7561426 YP_002645710.1 CDS JTY_2661 NC_012207.1 2922761 2923120 R probably ArsR-family; transcriptional regulatory protein complement(2922761..2923120) Mycobacterium bovis BCG str. Tokyo 172 7561427 YP_002645711.1 CDS cadI NC_012207.1 2923222 2923680 D cadmium inducible protein 2923222..2923680 Mycobacterium bovis BCG str. Tokyo 172 7561428 YP_002645712.1 CDS JTY_2663 NC_012207.1 2923816 2924196 D probably ArsR-family; transcriptional regulatory protein 2923816..2924196 Mycobacterium bovis BCG str. Tokyo 172 7562079 YP_002645713.1 CDS arsC NC_012207.1 2924193 2925689 D Differs from Rv2643 by 1 aa A455V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; arsenic-transport integral membrane protein 2924193..2925689 Mycobacterium bovis BCG str. Tokyo 172 7561429 YP_002645714.1 CDS JTY_2665 NC_012207.1 2925816 2926133 R hypothetical protein complement(2925816..2926133) Mycobacterium bovis BCG str. Tokyo 172 7562038 YP_002645715.1 CDS JTY_2666 NC_012207.1 2927270 2927491 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 10982 bp deletion (RD11 region) leads to deletion of genes between Rv2645 and Rv2659c compared to Mycobacterium tuberculosis strain H37Rv; hypothetical protein complement(2927270..2927491) Mycobacterium bovis BCG str. Tokyo 172 7561679 YP_002645716.1 CDS JTY_2667 NC_012207.1 2927488 2927877 R hypothetical protein complement(2927488..2927877) Mycobacterium bovis BCG str. Tokyo 172 7561431 YP_002645717.1 CDS JTY_2668 NC_012207.1 2927783 2928055 D hypothetical protein 2927783..2928055 Mycobacterium bovis BCG str. Tokyo 172 7561432 YP_002645718.1 CDS JTY_2669 NC_012207.1 2928154 2928387 D hypothetical protein 2928154..2928387 Mycobacterium bovis BCG str. Tokyo 172 7561433 YP_002645719.1 CDS JTY_2670 NC_012207.1 2928398 2928652 D hypothetical protein 2928398..2928652 Mycobacterium bovis BCG str. Tokyo 172 7561434 YP_002645722.1 CDS JTY_2673 NC_012207.1 2929372 2930175 D transposase for insertion sequence element IS1081 2929372..2930175 Mycobacterium bovis BCG str. Tokyo 172 7561435 YP_002645723.1 CDS clpX' NC_012207.1 2930197 2930955 D ATP-dependent protease ATP-binding subunit 2930197..2930955 Mycobacterium bovis BCG str. Tokyo 172 7561436 YP_002645724.1 CDS JTY_2675 NC_012207.1 2931034 2931555 D Differs from Rv2668 by 2aa R3H and K162E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; exported alanine and valine rich protein 2931034..2931555 Mycobacterium bovis BCG str. Tokyo 172 7562113 YP_002645725.1 CDS JTY_2676 NC_012207.1 2931584 2932054 D hypothetical protein 2931584..2932054 Mycobacterium bovis BCG str. Tokyo 172 7561437 YP_002645726.1 CDS JTY_2677 NC_012207.1 2932032 2933141 R hypothetical protein complement(2932032..2933141) Mycobacterium bovis BCG str. Tokyo 172 7561438 YP_002645727.1 CDS ribD NC_012207.1 2933140 2933916 D hypothetical protein 2933140..2933916 Mycobacterium bovis BCG str. Tokyo 172 7561439 YP_002645728.1 CDS JTY_2679 NC_012207.1 2933983 2935569 D Differs from Rv2672 by 1aa D317H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; protease 2933983..2935569 Mycobacterium bovis BCG str. Tokyo 172 7561574 YP_002645729.1 CDS JTY_2680 NC_012207.1 2935592 2936893 D transmembrane protein 2935592..2936893 Mycobacterium bovis BCG str. Tokyo 172 7561440 YP_002645730.1 CDS JTY_2681 NC_012207.1 2937062 2937472 D hypothetical protein 2937062..2937472 Mycobacterium bovis BCG str. Tokyo 172 7561441 YP_002645731.1 CDS JTY_2682 NC_012207.1 2937540 2938292 R hypothetical protein complement(2937540..2938292) Mycobacterium bovis BCG str. Tokyo 172 7561442 YP_002645732.1 CDS JTY_2683 NC_012207.1 2938289 2938984 R hypothetical protein complement(2938289..2938984) Mycobacterium bovis BCG str. Tokyo 172 7561443 YP_002645733.1 CDS hemY NC_012207.1 2938990 2940348 R catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX; protoporphyrinogen oxidase complement(2938990..2940348) Mycobacterium bovis BCG str. Tokyo 172 7561444 YP_002645734.1 CDS hemE NC_012207.1 2940345 2941418 R catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase complement(2940345..2941418) Mycobacterium bovis BCG str. Tokyo 172 7563305 YP_002645735.1 CDS JTY_2686 NC_012207.1 2941471 2942301 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2941471..2942301 Mycobacterium bovis BCG str. Tokyo 172 7563301 YP_002645736.1 CDS JTY_2687 NC_012207.1 2942563 2943195 D hypothetical protein 2942563..2943195 Mycobacterium bovis BCG str. Tokyo 172 7561445 YP_002645737.1 CDS JTY_2688 NC_012207.1 2943197 2944513 D Differs from Rv2681 by 1aa V196A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical alanine rich protein 2943197..2944513 Mycobacterium bovis BCG str. Tokyo 172 7561446 YP_002645738.1 CDS dxs1 NC_012207.1 2944510 2946426 R catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase complement(2944510..2946426) Mycobacterium bovis BCG str. Tokyo 172 7561447 YP_002645739.1 CDS JTY_2690 NC_012207.1 2946570 2947067 D Differs from Rv2683 by 1aa, S84L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 2946570..2947067 Mycobacterium bovis BCG str. Tokyo 172 7561520 YP_002645740.1 CDS arsA NC_012207.1 2947072 2948361 D arsenic-transport integral membrane protein 2947072..2948361 Mycobacterium bovis BCG str. Tokyo 172 7561448 YP_002645741.1 CDS arsB1 NC_012207.1 2948441 2949727 D Differs from Rv2685 by 1aa, G378A and Mb2704, by 1aa, G393C in BCG Pasteur and BCG Tokyo; arsenic-transport integral membrane protein 2948441..2949727 Mycobacterium bovis BCG str. Tokyo 172 7564003 YP_002645742.1 CDS JTY_2693 NC_012207.1 2949738 2950496 R antibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter complement(2949738..2950496) Mycobacterium bovis BCG str. Tokyo 172 7562036 YP_002645743.1 CDS JTY_2694 NC_012207.1 2950493 2951206 R antibiotic-transport integral membrane leucine and valine rich protein ABC transporter complement(2950493..2951206) Mycobacterium bovis BCG str. Tokyo 172 7561449 YP_002645744.1 CDS JTY_2695 NC_012207.1 2951203 2952108 R Differs from Rv2688c by 1aa, T156P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; antibiotic-transport ATP-binding protein ABC transporter complement(2951203..2952108) Mycobacterium bovis BCG str. Tokyo 172 7562282 YP_002645745.1 CDS JTY_2696 NC_012207.1 2952303 2953520 R hypothetical alanine and valine and glycine rich protein complement(2952303..2953520) Mycobacterium bovis BCG str. Tokyo 172 7562283 YP_002645746.1 CDS JTY_2697 NC_012207.1 2953676 2955667 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (t-c) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (663 aa versus 657aa); integral membrane alanine and valine and leucine rich protein complement(2953676..2955667) Mycobacterium bovis BCG str. Tokyo 172 7562284 YP_002645747.1 CDS ceoB NC_012207.1 2955802 2956485 D Differs from Rv2691 by 1aa, A117T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; trk system potassium uptake protein 2955802..2956485 Mycobacterium bovis BCG str. Tokyo 172 7562285 YP_002645748.1 CDS ceoC NC_012207.1 2956482 2957144 D Differs from Rv2692 by 1aa, V133I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; trk system potassium uptake protein 2956482..2957144 Mycobacterium bovis BCG str. Tokyo 172 7562095 YP_002645749.1 CDS JTY_2700 NC_012207.1 2957155 2957826 R integral membrane alanine and leucine rich protein complement(2957155..2957826) Mycobacterium bovis BCG str. Tokyo 172 7562096 YP_002645750.1 CDS JTY_2701 NC_012207.1 2957857 2958225 R Differs from Rv2694c by 1aa, S68R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2957857..2958225) Mycobacterium bovis BCG str. Tokyo 172 7562286 YP_002645751.1 CDS JTY_2702 NC_012207.1 2958374 2959081 D hypothetical alanine rich protein 2958374..2959081 Mycobacterium bovis BCG str. Tokyo 172 7562287 YP_002645752.1 CDS JTY_2703 NC_012207.1 2959287 2960066 R Differs from Rv2696c by 1aa, N164D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical alanine and glycine and valine rich protein complement(2959287..2960066) Mycobacterium bovis BCG str. Tokyo 172 7562288 YP_002645753.1 CDS dut NC_012207.1 2960141 2960605 R catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase complement(2960141..2960605) Mycobacterium bovis BCG str. Tokyo 172 7562289 YP_002645754.1 CDS JTY_2705 NC_012207.1 2960631 2961116 D alanine rich transmembrane protein 2960631..2961116 Mycobacterium bovis BCG str. Tokyo 172 7561518 YP_002645755.1 CDS JTY_2706 NC_012207.1 2961121 2961423 R hypothetical protein complement(2961121..2961423) Mycobacterium bovis BCG str. Tokyo 172 7562290 YP_002645756.1 CDS JTY_2707 NC_012207.1 2961661 2962311 D alanine rich protein 2961661..2962311 Mycobacterium bovis BCG str. Tokyo 172 7562291 YP_002645757.1 CDS suhB NC_012207.1 2962321 2963193 R extragenic suppressor protein complement(2962321..2963193) Mycobacterium bovis BCG str. Tokyo 172 7562292 YP_002645758.1 CDS ppgK NC_012207.1 2963316 2964113 D Differs from Rv2702 by 1aa, T203I in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; polyphosphate glucokinase 2963316..2964113 Mycobacterium bovis BCG str. Tokyo 172 7561819 YP_002645759.1 CDS sigA NC_012207.1 2964293 2965879 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RNA polymerase sigma factor 2964293..2965879 Mycobacterium bovis BCG str. Tokyo 172 7560805 YP_002645760.1 CDS JTY_2711 NC_012207.1 2965916 2966344 D hypothetical protein 2965916..2966344 Mycobacterium bovis BCG str. Tokyo 172 7560789 YP_002645761.1 CDS JTY_2712 NC_012207.1 2966272 2966661 R hypothetical protein complement(2966272..2966661) Mycobacterium bovis BCG str. Tokyo 172 7562293 YP_002645762.1 CDS JTY_2713 NC_012207.1 2966658 2966915 R hypothetical protein complement(2966658..2966915) Mycobacterium bovis BCG str. Tokyo 172 7562294 YP_002645763.1 CDS JTY_2714 NC_012207.1 2967031 2968005 D transmembrane alanine and leucine rich protein 2967031..2968005 Mycobacterium bovis BCG str. Tokyo 172 7562295 YP_002645764.1 CDS JTY_2715 NC_012207.1 2968006 2968254 R hypothetical protein complement(2968006..2968254) Mycobacterium bovis BCG str. Tokyo 172 7562296 YP_002645765.1 CDS JTY_2716 NC_012207.1 2968297 2968743 D Differs from Rv2709 by 1aa, S35T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 2968297..2968743 Mycobacterium bovis BCG str. Tokyo 172 7562297 YP_002645766.1 CDS sigB NC_012207.1 2968919 2969890 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma factors in this cluster are active during stationary phase; RNA polymerase sigma factor SigB 2968919..2969890 Mycobacterium bovis BCG str. Tokyo 172 7562298 YP_002645767.1 CDS ideR NC_012207.1 2970023 2970715 D iron-dependent repressor and activator 2970023..2970715 Mycobacterium bovis BCG str. Tokyo 172 7560790 YP_002645768.1 CDS JTY_2719 NC_012207.1 2970728 2971786 R hypothetical protein complement(2970728..2971786) Mycobacterium bovis BCG str. Tokyo 172 7563342 YP_002645769.1 CDS sthA NC_012207.1 2971899 2973305 D catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 2971899..2973305 Mycobacterium bovis BCG str. Tokyo 172 7562299 YP_002645770.1 CDS JTY_2721 NC_012207.1 2973523 2974497 D Differs from Rv2714 by 2aa, W181S, A245V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical alanine and leucine rich protein 2973523..2974497 Mycobacterium bovis BCG str. Tokyo 172 7561811 YP_002645771.1 CDS JTY_2722 NC_012207.1 2974556 2975581 D hydrolase 2974556..2975581 Mycobacterium bovis BCG str. Tokyo 172 7562300 YP_002645772.1 CDS JTY_2723 NC_012207.1 2975630 2976316 D hypothetical protein 2975630..2976316 Mycobacterium bovis BCG str. Tokyo 172 7562301 YP_002645773.1 CDS JTY_2724 NC_012207.1 2976325 2976819 R hypothetical protein complement(2976325..2976819) Mycobacterium bovis BCG str. Tokyo 172 7562302 YP_002645774.1 CDS nrdR NC_012207.1 2976871 2977335 R transcriptional regulator NrdR complement(2976871..2977335) Mycobacterium bovis BCG str. Tokyo 172 7562303 YP_002645775.1 CDS JTY_2726 NC_012207.1 2977498 2977995 R Differs from Rv2719c by 1aa, H124Y in Mycobacteium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(2977498..2977995) Mycobacterium bovis BCG str. Tokyo 172 7562304 YP_002645776.1 CDS lexA NC_012207.1 2978303 2978956 D Represses a number of genes involved in the response to DNA damage; LexA repressor 2978303..2978956 Mycobacterium bovis BCG str. Tokyo 172 7562305 YP_002645777.1 CDS JTY_2728 NC_012207.1 2978978 2981077 R Differs from Rv2721c and Mb2740c by 2aa, S251G, A326T in BCG Pasteur and BCG Tokyo; transmembrane alanine and glycine rich protein complement(2978978..2981077) Mycobacterium bovis BCG str. Tokyo 172 7562823 YP_002645778.1 CDS JTY_2729 NC_012207.1 2981093 2981341 D hypothetical protein 2981093..2981341 Mycobacterium bovis BCG str. Tokyo 172 7562306 YP_002645779.1 CDS JTY_2730 NC_012207.1 2981367 2982560 D integral membrane protein 2981367..2982560 Mycobacterium bovis BCG str. Tokyo 172 7562307 YP_002645780.1 CDS fadE20 NC_012207.1 2982589 2983749 R Differs from Rv2724c by 1aa, T127I, and from Mb2743c by 1aa, P33A in BCG Pasteur and BCG Tokyo; acyl-CoA dehydrogenase complement(2982589..2983749) Mycobacterium bovis BCG str. Tokyo 172 7562308 YP_002645781.1 CDS hflX NC_012207.1 2983885 2985372 R Differs from Rv2725c and Mb2744c by 1aa, D218G in BCG Pasteur and BCG Tokyo; GTP-binding protein complement(2983885..2985372) Mycobacterium bovis BCG str. Tokyo 172 7563369 YP_002645782.1 CDS dapF NC_012207.1 2985389 2986258 R involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase complement(2985389..2986258) Mycobacterium bovis BCG str. Tokyo 172 7563307 YP_002645783.1 CDS miaA NC_012207.1 2986283 2987227 R IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase complement(2986283..2987227) Mycobacterium bovis BCG str. Tokyo 172 7561469 YP_002645784.1 CDS JTY_2735 NC_012207.1 2987224 2987919 R hypothetical alanine rich protein complement(2987224..2987919) Mycobacterium bovis BCG str. Tokyo 172 7564473 YP_002645785.1 CDS JTY_2736 NC_012207.1 2988028 2988933 R Differs from Rv2729c by 3aa, L41F, E202A, V266A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane alanine and valine and leucine rich protein complement(2988028..2988933) Mycobacterium bovis BCG str. Tokyo 172 7562309 YP_002645786.1 CDS JTY_2737 NC_012207.1 2989000 2989476 D hypothetical protein 2989000..2989476 Mycobacterium bovis BCG str. Tokyo 172 7562310 YP_002645787.1 CDS JTY_2738 NC_012207.1 2989484 2990836 D hypothetical alanine and arginine rich protein 2989484..2990836 Mycobacterium bovis BCG str. Tokyo 172 7562311 YP_002645788.1 CDS JTY_2739 NC_012207.1 2990833 2991447 R transmembrane protein complement(2990833..2991447) Mycobacterium bovis BCG str. Tokyo 172 7562312 YP_002645789.1 CDS JTY_2740 NC_012207.1 2991444 2992982 R catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase complement(2991444..2992982) Mycobacterium bovis BCG str. Tokyo 172 7562313 YP_002645790.1 CDS JTY_2741 NC_012207.1 2993279 2994133 D hypothetical protein 2993279..2994133 Mycobacterium bovis BCG str. Tokyo 172 7562314 YP_002645791.1 CDS JTY_2742 NC_012207.1 2994018 2995010 R hypothetical protein complement(2994018..2995010) Mycobacterium bovis BCG str. Tokyo 172 7562315 YP_002645792.1 CDS recX NC_012207.1 2995020 2995544 R binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX complement(2995020..2995544) Mycobacterium bovis BCG str. Tokyo 172 7562316 YP_002645793.1 CDS recA NC_012207.1 2995510 2997882 R these RecA proteins contain inteins; catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; DNA recombination protein RecA complement(2995510..2997882) Mycobacterium bovis BCG str. Tokyo 172 7561563 YP_002645794.1 CDS JTY_2745 NC_012207.1 2998077 2998250 D hypothetical protein 2998077..2998250 Mycobacterium bovis BCG str. Tokyo 172 7561553 YP_002645795.1 CDS JTY_2746 NC_012207.1 2998264 2998470 R hypothetical protein complement(2998264..2998470) Mycobacterium bovis BCG str. Tokyo 172 7562317 YP_002645796.1 CDS JTY_2747 NC_012207.1 2998481 2999647 R alanine rich transferase complement(2998481..2999647) Mycobacterium bovis BCG str. Tokyo 172 7562318 YP_002645797.1 CDS ephG NC_012207.1 2999691 3000140 D epoxide hydrolase 2999691..3000140 Mycobacterium bovis BCG str. Tokyo 172 7562319 YP_002645799.1 CDS PE_PGRS47 NC_012207.1 3000416 3001690 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, deletions of a single base (t-*) and of 84 bp (H37Rv2.3054724-3054807-*) leads to a shorter product with a different 5' start compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Also has lost 174 bp compared to Mb2761; PE-PGRS family protein 3000416..3001690 Mycobacterium bovis BCG str. Tokyo 172 7562373 YP_002645800.1 CDS JTY_2751 NC_012207.1 3001714 3001962 R In Mycobacterium tuberculosis strain H37Rv, Rv2742c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a 23bp insertion splits Rv2742c into two parts; hypothetical arginine rich protein complement(3001714..3001962) Mycobacterium bovis BCG str. Tokyo 172 7562372 YP_002645801.1 CDS JTY_2752 NC_012207.1 3001983 3002570 R In Mycobacterium tuberculosis strain H37Rv, Rv2742c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a 23bp insertion splits Rv2742c into two parts; hypothetical arginine rich protein complement(3001983..3002570) Mycobacterium bovis BCG str. Tokyo 172 7562320 YP_002645802.1 CDS JTY_2753 NC_012207.1 3002642 3003454 R membrane alanine rich protein complement(3002642..3003454) Mycobacterium bovis BCG str. Tokyo 172 7562321 YP_002645803.1 CDS 35kd_ag NC_012207.1 3003473 3004285 R Differs from Mb2765c by 1aa, K153Q in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; conserved 35 kda alanine rich protein complement(3003473..3004285) Mycobacterium bovis BCG str. Tokyo 172 7562322 YP_002645804.1 CDS JTY_2755 NC_012207.1 3004415 3004753 R transcriptional regulatory protein complement(3004415..3004753) Mycobacterium bovis BCG str. Tokyo 172 7564325 YP_002645805.1 CDS pgsA3 NC_012207.1 3004824 3005453 R pgp synthase pgsA3 complement(3004824..3005453) Mycobacterium bovis BCG str. Tokyo 172 7562323 YP_002645806.1 CDS JTY_2757 NC_012207.1 3005484 3006008 D catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis; N-acetylglutamate synthase 3005484..3006008 Mycobacterium bovis BCG str. Tokyo 172 7562403 YP_002645807.1 CDS ftsK NC_012207.1 3006077 3008728 R cell division transmembrane protein complement(3006077..3008728) Mycobacterium bovis BCG str. Tokyo 172 7562324 YP_002645808.1 CDS JTY_2759 NC_012207.1 3008727 3009041 D hypothetical protein 3008727..3009041 Mycobacterium bovis BCG str. Tokyo 172 7561878 YP_002645809.1 CDS JTY_2760 NC_012207.1 3009038 3009856 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 3009038..3009856 Mycobacterium bovis BCG str. Tokyo 172 7562325 YP_002645810.1 CDS JTY_2761 NC_012207.1 3009860 3010750 D hypothetical protein 3009860..3010750 Mycobacterium bovis BCG str. Tokyo 172 7562326 YP_002645811.1 CDS JTY_2762 NC_012207.1 3010737 3012413 R hypothetical protein complement(3010737..3012413) Mycobacterium bovis BCG str. Tokyo 172 7562327 YP_002645812.1 CDS dapA NC_012207.1 3012444 3013346 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(3012444..3013346) Mycobacterium bovis BCG str. Tokyo 172 7562328 YP_002645813.1 CDS thyX NC_012207.1 3013415 3014167 R flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase complement(3013415..3014167) Mycobacterium bovis BCG str. Tokyo 172 7561466 YP_002645814.1 CDS hsdS' NC_012207.1 3014411 3014686 R type I restriction/modification system specificity determinant complement(3014411..3014686) Mycobacterium bovis BCG str. Tokyo 172 7561858 YP_002645815.1 CDS hsdM NC_012207.1 3014683 3016305 R Differs from Rv2756c by 1aa, P306L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; type I restriction/modification system DNA methylase complement(3014683..3016305) Mycobacterium bovis BCG str. Tokyo 172 7563327 YP_002645816.1 CDS JTY_2767 NC_012207.1 3016392 3016808 R hypothetical protein complement(3016392..3016808) Mycobacterium bovis BCG str. Tokyo 172 7563325 YP_002645817.1 CDS JTY_2768 NC_012207.1 3016805 3017071 R hypothetical protein complement(3016805..3017071) Mycobacterium bovis BCG str. Tokyo 172 7562329 YP_002645818.1 CDS JTY_2769 NC_012207.1 3017097 3017492 R hypothetical protein complement(3017097..3017492) Mycobacterium bovis BCG str. Tokyo 172 7562330 YP_002645819.1 CDS JTY_2770 NC_012207.1 3017489 3017758 R hypothetical protein complement(3017489..3017758) Mycobacterium bovis BCG str. Tokyo 172 7562331 YP_002645820.1 CDS hsdS NC_012207.1 3017768 3018862 R type I restriction/modification system specificity determinant complement(3017768..3018862) Mycobacterium bovis BCG str. Tokyo 172 7562332 YP_002645821.1 CDS JTY_2772 NC_012207.1 3018859 3019131 R In Mycobacterium tuberculosis strain H37Rv, Rv2762c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (C-T) splits Rv2762c into 2 parts; hypothetical protein complement(3018859..3019131) Mycobacterium bovis BCG str. Tokyo 172 7563326 YP_002645822.1 CDS JTY_2773 NC_012207.1 3019147 3019278 R In Mycobacterium tuberculosis strain H37Rv, Rv2762c exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (C-T) splits Rv2762c into 2 parts; hypothetical protein complement(3019147..3019278) Mycobacterium bovis BCG str. Tokyo 172 7562333 YP_002645823.1 CDS dfrA NC_012207.1 3019352 3019831 R dihydrofolate reductase complement(3019352..3019831) Mycobacterium bovis BCG str. Tokyo 172 7562334 YP_002645824.1 CDS thyA NC_012207.1 3019902 3020693 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(3019902..3020693) Mycobacterium bovis BCG str. Tokyo 172 7561490 YP_002645825.1 CDS JTY_2776 NC_012207.1 3020858 3021595 D Differs from Rv2765 and Mb2787 by 1aa, I129M in BCG Pasteur and BCG Tokyo; alanine rich hydrolase 3020858..3021595 Mycobacterium bovis BCG str. Tokyo 172 7561857 YP_002645826.1 CDS fabG NC_012207.1 3021810 3022592 R Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(3021810..3022592) Mycobacterium bovis BCG str. Tokyo 172 7562335 YP_002645827.1 CDS JTY_2778 NC_012207.1 3022589 3022942 R Differs from Rv2767c and Mb2789c by 1aa, L26S in BCG Pasteur and BCG Tokyo; hypothetical protein complement(3022589..3022942) Mycobacterium bovis BCG str. Tokyo 172 7562898 YP_002645828.1 CDS PPE43 NC_012207.1 3023116 3024300 R Differs from Rv2768c by 1aa, R263P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PPE family protein complement(3023116..3024300) Mycobacterium bovis BCG str. Tokyo 172 7562336 YP_002645829.1 CDS PE27 NC_012207.1 3024380 3025207 R Differs from Rv2769c by 2aa, S54P, M270V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PE family protein complement(3024380..3025207) Mycobacterium bovis BCG str. Tokyo 172 7562181 YP_002645830.1 CDS PPE44 NC_012207.1 3025531 3026679 R Differs from Rv2770c by 1aa, S194F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PPE family protein complement(3025531..3026679) Mycobacterium bovis BCG str. Tokyo 172 7561727 YP_002645831.1 CDS JTY_2782 NC_012207.1 3026803 3027255 R Differs from Rv2771c by 1aa, P80L in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3026803..3027255) Mycobacterium bovis BCG str. Tokyo 172 7562182 YP_002645832.1 CDS JTY_2783 NC_012207.1 3027341 3027814 R transmembrane protein complement(3027341..3027814) Mycobacterium bovis BCG str. Tokyo 172 7562337 YP_002645833.1 CDS dapB NC_012207.1 3027826 3028563 R catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase complement(3027826..3028563) Mycobacterium bovis BCG str. Tokyo 172 7562338 YP_002645834.1 CDS JTY_2785 NC_012207.1 3028574 3028978 R hypothetical protein complement(3028574..3028978) Mycobacterium bovis BCG str. Tokyo 172 7561467 YP_002645835.1 CDS JTY_2786 NC_012207.1 3029131 3029592 D hypothetical protein 3029131..3029592 Mycobacterium bovis BCG str. Tokyo 172 7562339 YP_002645836.1 CDS JTY_2787 NC_012207.1 3029596 3030525 R oxidoreductase complement(3029596..3030525) Mycobacterium bovis BCG str. Tokyo 172 7562340 YP_002645837.1 CDS JTY_2788 NC_012207.1 3030707 3031777 R hypothetical protein complement(3030707..3031777) Mycobacterium bovis BCG str. Tokyo 172 7562341 YP_002645838.1 CDS JTY_2789 NC_012207.1 3031935 3032405 R hypothetical protein complement(3031935..3032405) Mycobacterium bovis BCG str. Tokyo 172 7562342 YP_002645839.1 CDS JTY_2790 NC_012207.1 3032437 3032976 R In Mycobacterium bovis, a 24 bp deletion leads to a shorter product compared to its homolog in Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv (171 aa versus 179 aa) Differs from Rv2779c by 1aa, I9M, and 8 aa longer than Mb2801c; probably lrp/AsnC-family; transcriptional regulatory protein complement(3032437..3032976) Mycobacterium bovis BCG str. Tokyo 172 7562343 YP_002645840.1 CDS ald_a NC_012207.1 3033042 3033440 D In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and in Mycobacterium bovis, a frameshift due to a single base deletion (A-*) splits ald into 2 parts, alda and aldb; L-alanine dehydrogenase 3033042..3033440 Mycobacterium bovis BCG str. Tokyo 172 7562344 YP_002645841.1 CDS aldB NC_012207.1 3033437 3034156 D In Mycobacterium tuberculosis strain H37Rv, ald exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and in Mycobacterium bovis, a frameshift due to a single base deletion (A-*) splits ald into 2 parts, alda and aldb; L-alanine dehydrogenase 3033437..3034156 Mycobacterium bovis BCG str. Tokyo 172 7563961 YP_002645842.1 CDS JTY_2793 NC_012207.1 3034171 3035205 R alanine rich oxidoreductase complement(3034171..3035205) Mycobacterium bovis BCG str. Tokyo 172 7563959 YP_002645843.1 CDS pepR NC_012207.1 3035266 3036582 R zinc protease complement(3035266..3036582) Mycobacterium bovis BCG str. Tokyo 172 7562345 YP_002645844.1 CDS gpsI NC_012207.1 3036560 3038818 R polynucleotide phosphorylase complement(3036560..3038818) Mycobacterium bovis BCG str. Tokyo 172 7561747 YP_002645845.1 CDS lppU NC_012207.1 3039172 3039687 R lipoprotein complement(3039172..3039687) Mycobacterium bovis BCG str. Tokyo 172 7563278 YP_002645846.1 CDS rpsO NC_012207.1 3039700 3039969 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(3039700..3039969) Mycobacterium bovis BCG str. Tokyo 172 7560487 YP_002645847.1 CDS ribF NC_012207.1 3040126 3041121 R catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase complement(3040126..3041121) Mycobacterium bovis BCG str. Tokyo 172 7560743 YP_002645848.1 CDS JTY_2799 NC_012207.1 3041332 3043095 D Differs from Rv2787 and Mb2810 by 1aa, P78T; hypothetical alanine rich protein 3041332..3043095 Mycobacterium bovis BCG str. Tokyo 172 7561575 YP_002645849.1 CDS sirR NC_012207.1 3043180 3043866 D Differs from Rv2788 by 1aa, A137D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transcriptional repressor 3043180..3043866 Mycobacterium bovis BCG str. Tokyo 172 7562346 YP_002645850.1 CDS fadE21 NC_012207.1 3043927 3045159 R acyl-CoA dehydrogenase complement(3043927..3045159) Mycobacterium bovis BCG str. Tokyo 172 7561799 YP_002645851.1 CDS ltp1 NC_012207.1 3045185 3046390 R lipid-transfer protein complement(3045185..3046390) Mycobacterium bovis BCG str. Tokyo 172 7563370 YP_002645852.1 CDS JTY_2803 NC_012207.1 3046423 3047802 R transposase complement(3046423..3047802) Mycobacterium bovis BCG str. Tokyo 172 7560538 YP_002645853.1 CDS JTY_2804 NC_012207.1 3047802 3048383 R Differs from Mb2815c by 2aa, A17V, T80E in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; resolvase complement(3047802..3048383) Mycobacterium bovis BCG str. Tokyo 172 7562347 YP_002645854.1 CDS truB NC_012207.1 3048585 3049481 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(3048585..3049481) Mycobacterium bovis BCG str. Tokyo 172 7562348 YP_002645855.1 CDS JTY_2806 NC_012207.1 3049478 3050161 R Differs from Rv2794c by 1aa, V87M in Mycobacterium tuberculosis CDC1551 in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3049478..3050161) Mycobacterium bovis BCG str. Tokyo 172 7561637 YP_002645856.1 CDS JTY_2807 NC_012207.1 3050158 3051132 R hypothetical protein complement(3050158..3051132) Mycobacterium bovis BCG str. Tokyo 172 7562349 YP_002645857.1 CDS lppV NC_012207.1 3051277 3051840 R Differs from Rv2796c by 1aa, F159C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein complement(3051277..3051840) Mycobacterium bovis BCG str. Tokyo 172 7562350 YP_002645858.1 CDS JTY_2809 NC_012207.1 3051840 3053528 R hypothetical protein complement(3051840..3053528) Mycobacterium bovis BCG str. Tokyo 172 7560488 YP_002645859.1 CDS JTY_2810 NC_012207.1 3053532 3053858 R hypothetical protein complement(3053532..3053858) Mycobacterium bovis BCG str. Tokyo 172 7562351 YP_002645860.1 CDS JTY_2811 NC_012207.1 3053989 3054618 D In Mycobacterium bovis, a 3 bp insertion (*-GGT) leads to a slightly longer product compared to its homolog in Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv (210 aa versus 209 aa); hypothetical protein 3053989..3054618 Mycobacterium bovis BCG str. Tokyo 172 7562352 YP_002645861.1 CDS JTY_2812 NC_012207.1 3054637 3056286 D hydrolase 3054637..3056286 Mycobacterium bovis BCG str. Tokyo 172 7562353 YP_002645862.1 CDS JTY_2813 NC_012207.1 3056388 3056744 R hypothetical protein complement(3056388..3056744) Mycobacterium bovis BCG str. Tokyo 172 7562354 YP_002645863.1 CDS JTY_2814 NC_012207.1 3057001 3058044 R hypothetical arginine and alanine rich protein complement(3057001..3058044) Mycobacterium bovis BCG str. Tokyo 172 7562355 YP_002645864.1 CDS JTY_2815 NC_012207.1 3058043 3058510 D hypothetical protein 3058043..3058510 Mycobacterium bovis BCG str. Tokyo 172 7562356 YP_002645865.1 CDS JTY_2816 NC_012207.1 3058686 3059315 R Differs from Rv2804c by 2aa, T58A, V74A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3058686..3059315) Mycobacterium bovis BCG str. Tokyo 172 7562357 YP_002645866.1 CDS JTY_2817 NC_012207.1 3059088 3059492 D Differs from Rv2805 by 1aa, D4G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3059088..3059492 Mycobacterium bovis BCG str. Tokyo 172 7562358 YP_002645867.1 CDS JTY_2818 NC_012207.1 3059489 3059680 D hypothetical protein 3059489..3059680 Mycobacterium bovis BCG str. Tokyo 172 7562359 YP_002645868.1 CDS JTY_2819 NC_012207.1 3059879 3061033 D Differs from Rv2807 by 2aa, V72E, T349M, and from Mb2830 by 1aa, T349M in BCG Pasteur and BCG Tokyo; hypothetical protein 3059879..3061033 Mycobacterium bovis BCG str. Tokyo 172 7562360 YP_002645869.1 CDS JTY_2820 NC_012207.1 3061267 3061524 D hypothetical protein 3061267..3061524 Mycobacterium bovis BCG str. Tokyo 172 7562361 YP_002645870.1 CDS JTY_2821 NC_012207.1 3061629 3061940 D Differs from Rv2809 by 1aa, P46T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3061629..3061940 Mycobacterium bovis BCG str. Tokyo 172 7562362 YP_002645871.1 CDS JTY_2823 NC_012207.1 3062360 3062968 D hypothetical protein 3062360..3062968 Mycobacterium bovis BCG str. Tokyo 172 7563758 YP_002645872.1 CDS JTY_2824 NC_012207.1 3063039 3064448 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, Rv2812 exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (TG-*) splits Rv2812 into 2 parts, Mb2835 and Mb2836. Differs from Rv2812 by 1 aa, G395R; transposase 3063039..3064448 Mycobacterium bovis BCG str. Tokyo 172 7563759 YP_002645873.1 CDS JTY_2825 NC_012207.1 3064445 3065257 D Differs from Rv2813 by 1aa, V76I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3064445..3065257 Mycobacterium bovis BCG str. Tokyo 172 7563760 YP_002645874.1 CDS JTY_2826 NC_012207.1 3066860 3067696 R transposase complement(3066860..3067696) Mycobacterium bovis BCG str. Tokyo 172 7563761 YP_002645875.1 CDS JTY_2827 NC_012207.1 3067795 3068121 R transposase complement(3067795..3068121) Mycobacterium bovis BCG str. Tokyo 172 7563762 YP_002645876.1 CDS JTY_2828 NC_012207.1 3070375 3070716 R hypothetical protein complement(3070375..3070716) Mycobacterium bovis BCG str. Tokyo 172 7563763 YP_002645877.1 CDS JTY_2829 NC_012207.1 3070717 3071733 R hypothetical protein complement(3070717..3071733) Mycobacterium bovis BCG str. Tokyo 172 7563764 YP_002645878.1 CDS JTY_2831 NC_012207.1 3071983 3072993 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (c-t) introduces a premature stop codon that leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (336 aa versus 382 aa); hypothetical protein complement(3071983..3072993) Mycobacterium bovis BCG str. Tokyo 172 7563766 YP_002645879.1 CDS JTY_2832 NC_012207.1 3072990 3074117 R hypothetical protein complement(3072990..3074117) Mycobacterium bovis BCG str. Tokyo 172 7563767 YP_002645880.1 CDS JTY_2833 NC_012207.1 3074114 3075022 R hypothetical protein complement(3074114..3075022) Mycobacterium bovis BCG str. Tokyo 172 7563768 YP_002645881.1 CDS JTY_2834 NC_012207.1 3075003 3075713 R hypothetical protein complement(3075003..3075713) Mycobacterium bovis BCG str. Tokyo 172 7563769 YP_002645882.1 CDS JTY_2835 NC_012207.1 3075723 3076097 R hypothetical protein complement(3075723..3076097) Mycobacterium bovis BCG str. Tokyo 172 7563770 YP_002645883.1 CDS JTY_2836 NC_012207.1 3076094 3078532 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 9 bp insertion (*-CGGCGATGT) leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv; hypothetical protein complement(3076094..3078532) Mycobacterium bovis BCG str. Tokyo 172 7563771 YP_002645884.1 CDS JTY_2837 NC_012207.1 3078529 3079473 R Differs from Mb2848c by 1aa H56P in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3078529..3079473) Mycobacterium bovis BCG str. Tokyo 172 7563772 YP_002645885.1 CDS JTY_2838 NC_012207.1 3079651 3080298 R Differs from Rv2825c by 5aa, E2K, C162S, L189V, Q192T, E195A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3079651..3080298) Mycobacterium bovis BCG str. Tokyo 172 7563773 YP_002645886.1 CDS JTY_2839 NC_012207.1 3080468 3081352 R hypothetical protein complement(3080468..3081352) Mycobacterium bovis BCG str. Tokyo 172 7563774 YP_002645887.1 CDS JTY_2840 NC_012207.1 3081355 3082242 R hypothetical protein complement(3081355..3082242) Mycobacterium bovis BCG str. Tokyo 172 7563775 YP_002645888.1 CDS JTY_2841 NC_012207.1 3082547 3083092 R Differs from Mb2852c by 1aa E58A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3082547..3083092) Mycobacterium bovis BCG str. Tokyo 172 7563776 YP_002645889.1 CDS JTY_2842 NC_012207.1 3083089 3083358 R hypothetical protein complement(3083089..3083358) Mycobacterium bovis BCG str. Tokyo 172 7563777 YP_002645890.1 CDS JTY_2843 NC_012207.1 3083379 3083771 R hypothetical protein complement(3083379..3083771) Mycobacterium bovis BCG str. Tokyo 172 7563778 YP_002645891.1 CDS JTY_2844 NC_012207.1 3083768 3083983 R Differs from Rv2830c by 1aa, V56A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3083768..3083983) Mycobacterium bovis BCG str. Tokyo 172 7563779 YP_002645892.1 CDS echA16 NC_012207.1 3084030 3084779 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 3084030..3084779 Mycobacterium bovis BCG str. Tokyo 172 7563780 YP_002645893.1 CDS ugpC NC_012207.1 3084858 3085940 R Differs from Rv2832c and Mb2856c by 1aa, L235F in BCG Pasteur and BCG Tokyo; sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter complement(3084858..3085940) Mycobacterium bovis BCG str. Tokyo 172 7561527 YP_002645894.1 CDS ugpBa NC_012207.1 3086611 3087243 R In mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base mutation (T->A) at corresponding position 3093840, in Mycobacterium tuberculosis H37Rv strain, leads to a stop codon and break ugpB in two parts. Differs from Rv2833c by 2aa, I111S, L174P in BCG Pasteur and BCG Tokyo; sn-glycerol-3-phosphate-transport integral membrane protein ABC transporter complement(3086611..3087243) Mycobacterium bovis BCG str. Tokyo 172 7561654 YP_002645895.1 CDS ugpE NC_012207.1 3087246 3088073 R sn-glycerol-3-phosphate transport integral membrane protein ABC transporter complement(3087246..3088073) Mycobacterium bovis BCG str. Tokyo 172 7561653 YP_002645896.1 CDS ugpA NC_012207.1 3088070 3088981 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo and Mycobacterium tuberculosis strain H37Rv, ugpA exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*) splits ugpA into 2 parts, ugpAaand ugpAb; sn-glycerol-3-phosphate transport integral membrane protein ABC transporter complement(3088070..3088981) Mycobacterium bovis BCG str. Tokyo 172 7561656 YP_002645897.1 CDS dinF NC_012207.1 3089068 3090387 R Differs from Rv2836c by 2aa, H157Q, L350P, and from Mb2861c by 1aa, H157Q in BCG Pasteur and BCG Tokyo; DNA-damage-inducible protein F complement(3089068..3090387) Mycobacterium bovis BCG str. Tokyo 172 7561652 YP_002645898.1 CDS JTY_2852 NC_012207.1 3090394 3091404 R hypothetical protein complement(3090394..3091404) Mycobacterium bovis BCG str. Tokyo 172 7561493 YP_002645899.1 CDS rbfA NC_012207.1 3091379 3091930 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(3091379..3091930) Mycobacterium bovis BCG str. Tokyo 172 7563781 YP_002645900.1 CDS infB NC_012207.1 3091930 3094632 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(3091930..3094632) Mycobacterium bovis BCG str. Tokyo 172 7561550 YP_002645901.1 CDS JTY_2855 NC_012207.1 3094718 3095017 R hypothetical protein complement(3094718..3095017) Mycobacterium bovis BCG str. Tokyo 172 7562786 YP_002645902.1 CDS nusA NC_012207.1 3095144 3096187 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(3095144..3096187) Mycobacterium bovis BCG str. Tokyo 172 7563782 YP_002645903.1 CDS JTY_2857 NC_012207.1 3096184 3096735 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(3096184..3096735) Mycobacterium bovis BCG str. Tokyo 172 7562488 YP_002645904.1 CDS JTY_2858 NC_012207.1 3096930 3097475 D transmembrane alanine rich protein 3096930..3097475 Mycobacterium bovis BCG str. Tokyo 172 7563783 YP_002645905.1 CDS JTY_2859 NC_012207.1 3097472 3097960 D hypothetical alanine rich protein 3097472..3097960 Mycobacterium bovis BCG str. Tokyo 172 7563784 YP_002645906.1 CDS proS NC_012207.1 3097961 3099709 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(3097961..3099709) Mycobacterium bovis BCG str. Tokyo 172 7563785 YP_002645907.1 CDS efpA NC_012207.1 3099798 3101390 R Differs from Rv2846c by 1aa, R15T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; integral membrane efflux protein complement(3099798..3101390) Mycobacterium bovis BCG str. Tokyo 172 7560827 YP_002645908.1 CDS cysG NC_012207.1 3101413 3102630 R uroporphyrin-III C-methyltransferase, precorrin-2 oxidase, ferrochelatase; siroheme synthase complement(3101413..3102630) Mycobacterium bovis BCG str. Tokyo 172 7562856 YP_002645909.1 CDS cobB NC_012207.1 3102961 3104334 R responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid; cobyrinic acid a,c-diamide synthase complement(3102961..3104334) Mycobacterium bovis BCG str. Tokyo 172 7563176 YP_002645910.1 CDS cobO NC_012207.1 3104334 3104957 R catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase complement(3104334..3104957) Mycobacterium bovis BCG str. Tokyo 172 7563103 YP_002645911.1 CDS JTY_2865 NC_012207.1 3104978 3106867 R Differs from Rv2850c by 2aa, Q273R, S446G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; magnesium chelatase complement(3104978..3106867) Mycobacterium bovis BCG str. Tokyo 172 7563114 YP_002645912.1 CDS JTY_2866 NC_012207.1 3106864 3107334 R hypothetical protein complement(3106864..3107334) Mycobacterium bovis BCG str. Tokyo 172 7563786 YP_002645913.1 CDS mqo NC_012207.1 3107393 3108874 R malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase complement(3107393..3108874) Mycobacterium bovis BCG str. Tokyo 172 7563787 YP_002645914.1 CDS PE_PGRS48 NC_012207.1 3109081 3110874 D Differs from Rv2853 by 3aa, N227K, G228R, D232G, and 18aa deletion, and from Mb2878 by 1aa, D184G, and same 18aa deletion in BCG Pasteur and BCG Tokyo; PE-PGRS family protein 3109081..3110874 Mycobacterium bovis BCG str. Tokyo 172 7563557 YP_002645915.1 CDS JTY_2869 NC_012207.1 3110911 3111951 D hypothetical protein 3110911..3111951 Mycobacterium bovis BCG str. Tokyo 172 7562374 YP_002645916.1 CDS mtr NC_012207.1 3111964 3113343 D catalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide; mycothione reductase 3111964..3113343 Mycobacterium bovis BCG str. Tokyo 172 7563788 YP_002645917.1 CDS nicT NC_012207.1 3113443 3114561 D nickel-transport integral membrane protein 3113443..3114561 Mycobacterium bovis BCG str. Tokyo 172 7563568 YP_002645918.1 CDS JTY_2872 NC_012207.1 3114627 3114959 D truncated hydrogenase nickle incorporation protein 3114627..3114959 Mycobacterium bovis BCG str. Tokyo 172 7562460 YP_002645919.1 CDS JTY_2873 NC_012207.1 3114971 3115186 D truncated hydrogenase nickle incorporation protein 3114971..3115186 Mycobacterium bovis BCG str. Tokyo 172 7563789 YP_002645920.1 CDS JTY_2874 NC_012207.1 3115342 3116118 R short chain dehydrogenase complement(3115342..3116118) Mycobacterium bovis BCG str. Tokyo 172 7563790 YP_002645921.1 CDS aldC NC_012207.1 3116115 3117482 R aldehyde dehydrogenase complement(3116115..3117482) Mycobacterium bovis BCG str. Tokyo 172 7563791 YP_002645922.1 CDS JTY_2876 NC_012207.1 3117479 3118405 R amidotransferase complement(3117479..3118405) Mycobacterium bovis BCG str. Tokyo 172 7563960 YP_002645923.1 CDS glnA4 NC_012207.1 3118386 3119759 R glutamine synthetase complement(3118386..3119759) Mycobacterium bovis BCG str. Tokyo 172 7563792 YP_002645924.1 CDS mapB NC_012207.1 3119919 3120776 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mnin Bacillus subtilis the protein in this cluster is considered non-essential; methionine aminopeptidase complement(3119919..3120776) Mycobacterium bovis BCG str. Tokyo 172 7561929 YP_002645925.1 CDS JTY_2879 NC_012207.1 3120818 3121402 R Differs from Rv2862c by 2aa, P18R, R50C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3120818..3121402) Mycobacterium bovis BCG str. Tokyo 172 7564419 YP_002645926.1 CDS JTY_2880 NC_012207.1 3121751 3122131 D hypothetical protein 3121751..3122131 Mycobacterium bovis BCG str. Tokyo 172 7563793 YP_002645927.1 CDS JTY_2881 NC_012207.1 3122213 3124024 R penicillin-binding lipoprotein complement(3122213..3124024) Mycobacterium bovis BCG str. Tokyo 172 7563794 YP_002645928.1 CDS JTY_2882 NC_012207.1 3124296 3124577 D hypothetical protein 3124296..3124577 Mycobacterium bovis BCG str. Tokyo 172 7563795 YP_002645929.1 CDS JTY_2883 NC_012207.1 3124581 3124844 D hypothetical protein 3124581..3124844 Mycobacterium bovis BCG str. Tokyo 172 7563796 YP_002645930.1 CDS JTY_2884 NC_012207.1 3125217 3126071 R hypothetical protein complement(3125217..3126071) Mycobacterium bovis BCG str. Tokyo 172 7563797 YP_002645931.1 CDS ispG NC_012207.1 3126127 3127290 R catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(3126127..3127290) Mycobacterium bovis BCG str. Tokyo 172 7563798 YP_002645932.1 CDS JTY_2886 NC_012207.1 3127307 3128521 R Differs from Mb2894c by 1aa, T330A, and from Rv2869c by 2aa, F259V, T330A in BCG Pasteur and BCG Tokyo; transmembrane protein complement(3127307..3128521) Mycobacterium bovis BCG str. Tokyo 172 7561908 YP_002645933.1 CDS dxr NC_012207.1 3128529 3129770 R catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase complement(3128529..3129770) Mycobacterium bovis BCG str. Tokyo 172 7563799 YP_002645934.1 CDS JTY_2888 NC_012207.1 3129897 3130154 D hypothetical protein 3129897..3130154 Mycobacterium bovis BCG str. Tokyo 172 7561519 YP_002645935.1 CDS JTY_2889 NC_012207.1 3130141 3130584 D Differs from Rv2872 and Mb2897 by 1aa, T72A in BCG Pasteur and BCG Tokyo; hypothetical protein 3130141..3130584 Mycobacterium bovis BCG str. Tokyo 172 7563800 YP_002645936.1 CDS mpb83 NC_012207.1 3130664 3131326 D cell surface lipoprotein 3130664..3131326 Mycobacterium bovis BCG str. Tokyo 172 7563801 YP_002645937.1 CDS dipZ NC_012207.1 3131606 3133693 D Differs from Rv2874 by 1aa, D672Y in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane C-type cytochrome biogenesis protein 3131606..3133693 Mycobacterium bovis BCG str. Tokyo 172 7563552 YP_002645938.1 CDS mpb70 NC_012207.1 3133789 3134370 D major immunogenic protein precursor 3133789..3134370 Mycobacterium bovis BCG str. Tokyo 172 7561497 YP_002645939.1 CDS JTY_2893 NC_012207.1 3134422 3134736 D hypothetical protein 3134422..3134736 Mycobacterium bovis BCG str. Tokyo 172 7563551 YP_002645940.1 CDS JTY_2894 NC_012207.1 3134767 3135630 R Differs from Rv2877c by 1aa, H35Y in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein complement(3134767..3135630) Mycobacterium bovis BCG str. Tokyo 172 7563802 YP_002645941.1 CDS mpb53 NC_012207.1 3135635 3136156 R soluble antigen complement(3135635..3136156) Mycobacterium bovis BCG str. Tokyo 172 7563803 YP_002645942.1 CDS JTY_2896 NC_012207.1 3136342 3137436 R 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N complement(3136342..3137436) Mycobacterium bovis BCG str. Tokyo 172 7563550 YP_002645943.1 CDS cdsA NC_012207.1 3137459 3138379 R integral membrane phosphatidate cytidylyltransferase complement(3137459..3138379) Mycobacterium bovis BCG str. Tokyo 172 7563804 YP_002645944.1 CDS frr NC_012207.1 3138402 3138959 R Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor complement(3138402..3138959) Mycobacterium bovis BCG str. Tokyo 172 7562091 YP_002645945.1 CDS pyrH NC_012207.1 3139131 3139916 R Catalyzes the phosphorylation of UMP to UDP; uridylate kinase complement(3139131..3139916) Mycobacterium bovis BCG str. Tokyo 172 7561875 YP_002645946.1 CDS JTY_2900 NC_012207.1 3140151 3140909 D transcriptional regulatory protein 3140151..3140909 Mycobacterium bovis BCG str. Tokyo 172 7561543 YP_002645947.1 CDS JTY_2901 NC_012207.1 3140988 3142307 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-c) leads to a truncation resulting in a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (439 aa versus 460 aa); transposase complement(3140988..3142307) Mycobacterium bovis BCG str. Tokyo 172 7563805 YP_002645948.1 CDS JTY_2902 NC_012207.1 3142304 3143191 R resolvase complement(3142304..3143191) Mycobacterium bovis BCG str. Tokyo 172 7563806 YP_002645949.1 CDS JTY_2903 NC_012207.1 3143190 3143609 D transcriptional regulatory protein 3143190..3143609 Mycobacterium bovis BCG str. Tokyo 172 7563807 YP_002645950.1 CDS amiC NC_012207.1 3143623 3145044 R catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase complement(3143623..3145044) Mycobacterium bovis BCG str. Tokyo 172 7563808 YP_002645951.1 CDS tsf NC_012207.1 3145051 3145866 R EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts complement(3145051..3145866) Mycobacterium bovis BCG str. Tokyo 172 7563973 YP_002645952.1 CDS rpsB NC_012207.1 3145878 3146741 R one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 complement(3145878..3146741) Mycobacterium bovis BCG str. Tokyo 172 7561642 YP_002645953.1 CDS JTY_2907 NC_012207.1 3147025 3147774 D hypothetical protein 3147025..3147774 Mycobacterium bovis BCG str. Tokyo 172 7560729 YP_002645954.1 CDS PPE45 NC_012207.1 3147553 3148779 R PPE family protein complement(3147553..3148779) Mycobacterium bovis BCG str. Tokyo 172 7563809 YP_002645955.1 CDS JTY_2909 NC_012207.1 3149179 3150156 D oxidoreductase 3149179..3150156 Mycobacterium bovis BCG str. Tokyo 172 7562183 YP_002645956.1 CDS xerC NC_012207.1 3150153 3151049 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC complement(3150153..3151049) Mycobacterium bovis BCG str. Tokyo 172 7563810 YP_002645957.1 CDS viuB NC_012207.1 3151140 3151991 R mycobactin utilization protein complement(3151140..3151991) Mycobacterium bovis BCG str. Tokyo 172 7561696 YP_002645958.1 CDS JTY_2912 NC_012207.1 3152024 3153193 R Differs from Rv2896c by 2aa, G57E, A153S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein complement(3152024..3153193) Mycobacterium bovis BCG str. Tokyo 172 7561682 YP_002645959.1 CDS JTY_2913 NC_012207.1 3153190 3154701 R hypothetical protein complement(3153190..3154701) Mycobacterium bovis BCG str. Tokyo 172 7563811 YP_002645960.1 CDS JTY_2914 NC_012207.1 3154701 3155087 R hypothetical protein complement(3154701..3155087) Mycobacterium bovis BCG str. Tokyo 172 7563812 YP_002645961.1 CDS fdhD NC_012207.1 3155335 3156165 R involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein complement(3155335..3156165) Mycobacterium bovis BCG str. Tokyo 172 7563813 YP_002645962.1 CDS fdhF NC_012207.1 3156165 3158504 R formate dehydrogenase H complement(3156165..3158504) Mycobacterium bovis BCG str. Tokyo 172 7563404 YP_002645963.1 CDS JTY_2917 NC_012207.1 3158562 3158867 R hypothetical protein complement(3158562..3158867) Mycobacterium bovis BCG str. Tokyo 172 7563405 YP_002645964.1 CDS rnhB NC_012207.1 3158921 3159715 R RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII complement(3158921..3159715) Mycobacterium bovis BCG str. Tokyo 172 7563814 YP_002645965.1 CDS lepB NC_012207.1 3159729 3160613 R Differs from Rv2903c by 1aa, N2564D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; signal peptidase I complement(3159729..3160613) Mycobacterium bovis BCG str. Tokyo 172 7561588 YP_002645966.1 CDS rplS NC_012207.1 3160671 3161012 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(3160671..3161012) Mycobacterium bovis BCG str. Tokyo 172 7562812 YP_002645967.1 CDS lppW NC_012207.1 3161387 3162331 D alanine rich lipoprotein 3161387..3162331 Mycobacterium bovis BCG str. Tokyo 172 7561619 YP_002645968.1 CDS trmD NC_012207.1 3162424 3163116 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(3162424..3163116) Mycobacterium bovis BCG str. Tokyo 172 7560489 YP_002645969.1 CDS rimM NC_012207.1 3163120 3163650 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(3163120..3163650) Mycobacterium bovis BCG str. Tokyo 172 7561626 YP_002645970.1 CDS JTY_2924 NC_012207.1 3163664 3163906 R hypothetical protein complement(3163664..3163906) Mycobacterium bovis BCG str. Tokyo 172 7561580 YP_002645971.1 CDS rpsP NC_012207.1 3163914 3164402 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(3163914..3164402) Mycobacterium bovis BCG str. Tokyo 172 7563815 YP_002645972.1 CDS JTY_2926 NC_012207.1 3164586 3165029 R hypothetical protein complement(3164586..3165029) Mycobacterium bovis BCG str. Tokyo 172 7560744 YP_002645973.1 CDS dacB2 NC_012207.1 3165098 3165973 D D-alanyl-D-alanine carboxypeptidase 3165098..3165973 Mycobacterium bovis BCG str. Tokyo 172 7563816 YP_002645974.1 CDS JTY_2928 NC_012207.1 3166033 3166620 R probably TetR-family; transcriptional regulatory protein complement(3166033..3166620) Mycobacterium bovis BCG str. Tokyo 172 7561465 YP_002645975.1 CDS JTY_2929 NC_012207.1 3166622 3168457 R D-amino acid aminohydrolase complement(3166622..3168457) Mycobacterium bovis BCG str. Tokyo 172 7563817 YP_002645976.1 CDS pknI NC_012207.1 3168526 3170283 R transmembrane serine/threonine-protein kinase I complement(3168526..3170283) Mycobacterium bovis BCG str. Tokyo 172 7563818 YP_002645977.1 CDS JTY_2931 NC_012207.1 3170327 3171439 R hypothetical protein complement(3170327..3171439) Mycobacterium bovis BCG str. Tokyo 172 7562436 YP_002645978.1 CDS ffh NC_012207.1 3171467 3173044 R signal recognition particle protein complement(3171467..3173044) Mycobacterium bovis BCG str. Tokyo 172 7563819 YP_002645979.1 CDS JTY_2933 NC_012207.1 3173122 3175002 D Differs from Rv2917 by 1aa, L594R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical alanine and arginine rich protein 3173122..3175002 Mycobacterium bovis BCG str. Tokyo 172 7563411 YP_002645980.1 CDS glnD NC_012207.1 3175013 3177439 R catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; also involved in adenylylating and deadelnylyating GlnK; PII uridylyl-transferase complement(3175013..3177439) Mycobacterium bovis BCG str. Tokyo 172 7563820 YP_002645981.1 CDS glnB NC_012207.1 3177497 3177835 R nitrogen regulatory protein P-II complement(3177497..3177835) Mycobacterium bovis BCG str. Tokyo 172 7561931 YP_002645982.1 CDS amt NC_012207.1 3177832 3179265 R ammonium-transport integral membrane protein complement(3177832..3179265) Mycobacterium bovis BCG str. Tokyo 172 7561930 YP_002645983.1 CDS ftsY NC_012207.1 3179742 3181010 R cell division protein complement(3179742..3181010) Mycobacterium bovis BCG str. Tokyo 172 7563975 YP_002645984.1 CDS smc NC_012207.1 3181060 3184677 R Differs from Rv2922c by 2aa, R364L, G698R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; chromosome partition protein complement(3181060..3184677) Mycobacterium bovis BCG str. Tokyo 172 7561882 YP_002645985.1 CDS acyP NC_012207.1 3184689 3184970 R catalyzes the hydrolysis of acylphosphate; acylphosphatase complement(3184689..3184970) Mycobacterium bovis BCG str. Tokyo 172 7561800 YP_002645986.1 CDS JTY_2940 NC_012207.1 3184957 3185370 R hypothetical protein complement(3184957..3185370) Mycobacterium bovis BCG str. Tokyo 172 7563936 YP_002645987.1 CDS fpg NC_012207.1 3185472 3186341 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(3185472..3186341) Mycobacterium bovis BCG str. Tokyo 172 7563821 YP_002645988.1 CDS rnc NC_012207.1 3186645 3187367 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(3186645..3187367) Mycobacterium bovis BCG str. Tokyo 172 7563426 YP_002645989.1 CDS JTY_2943 NC_012207.1 3187364 3187987 R hypothetical protein complement(3187364..3187987) Mycobacterium bovis BCG str. Tokyo 172 7561586 YP_002645990.1 CDS JTY_2944 NC_012207.1 3188038 3188775 R hypothetical protein complement(3188038..3188775) Mycobacterium bovis BCG str. Tokyo 172 7563822 YP_002645991.1 CDS tesA NC_012207.1 3189014 3189799 D thioesterase 3189014..3189799 Mycobacterium bovis BCG str. Tokyo 172 7563823 YP_002645992.1 CDS JTY_2946 NC_012207.1 3189786 3190097 D hypothetical protein 3189786..3190097 Mycobacterium bovis BCG str. Tokyo 172 7561839 YP_002645993.1 CDS fadD26 NC_012207.1 3190513 3192264 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3190513..3192264 Mycobacterium bovis BCG str. Tokyo 172 7563824 YP_002645994.1 CDS ppsA NC_012207.1 3192261 3197891 D Differs from Rv2931 at several positions in BCG Pasteur and BCG Tokyo; phenolpthiocerol synthesis type-I polyketide synthase 3192261..3197891 Mycobacterium bovis BCG str. Tokyo 172 7562932 YP_002645995.1 CDS ppsB NC_012207.1 3197888 3202504 D Differs from Mb2957 and Rv2932 at several positions in BCG Pasteur and BCG Tokyo; phenolpthiocerol synthesis type-I polyketide synthase 3197888..3202504 Mycobacterium bovis BCG str. Tokyo 172 7560812 YP_002645996.1 CDS ppsC NC_012207.1 3202501 3209067 D phenolpthiocerol synthesis type-I polyketide synthase 3202501..3209067 Mycobacterium bovis BCG str. Tokyo 172 7560813 YP_002645997.1 CDS ppsD NC_012207.1 3209064 3214547 D Differs from Rv2934 at several positions in BCG Pasteur and BCG Tokyo; phenolpthiocerol synthesis type-I polyketide synthase 3209064..3214547 Mycobacterium bovis BCG str. Tokyo 172 7560814 YP_002645998.1 CDS ppsE NC_012207.1 3214553 3219019 D Differs from Rv2935 at several positions in BCG Pasteur and BCG Tokyo; phenolpthiocerol synthesis type-I polyketide synthase 3214553..3219019 Mycobacterium bovis BCG str. Tokyo 172 7560815 YP_002645999.1 CDS drrA NC_012207.1 3219030 3220025 D Differs from Rv2936 by 1aa, D309H in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; daunorubicin-DIM-transport ATP-binding protein ABC transporter 3219030..3220025 Mycobacterium bovis BCG str. Tokyo 172 7560816 YP_002646000.1 CDS drrB NC_012207.1 3220022 3220891 D daunorubicin-DIM-transport integral membrane protein ABC transporter 3220022..3220891 Mycobacterium bovis BCG str. Tokyo 172 7561514 YP_002646001.1 CDS drrC NC_012207.1 3220888 3221718 D daunorubicin-DIM-transport integral membrane protein ABC transporter 3220888..3221718 Mycobacterium bovis BCG str. Tokyo 172 7561515 YP_002646002.1 CDS papA5 NC_012207.1 3221765 3223033 D required for PDIM synthesis; phthiocerol and phthiodiolone dimycocerosate esters are scaffolds used for virulence-enhancing lipids; proposed to catalyze diesterification of phthiocerol and phthiodolone with mycocerosate; functions in polyketide synthesis; acyltransferase 3221765..3223033 Mycobacterium bovis BCG str. Tokyo 172 7561516 YP_002646003.1 CDS mas NC_012207.1 3223196 3229531 R multifunctional mycocerosic acid synthase membrane-associated complement(3223196..3229531) Mycobacterium bovis BCG str. Tokyo 172 7562515 YP_002646004.1 CDS fadD28 NC_012207.1 3230151 3231893 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3230151..3231893 Mycobacterium bovis BCG str. Tokyo 172 7564420 YP_002646005.1 CDS mmpL7 NC_012207.1 3231886 3234648 D conserved transmembrane transport protein 3231886..3234648 Mycobacterium bovis BCG str. Tokyo 172 7562933 YP_002646006.1 CDS JTY_2960 NC_012207.1 3235280 3236521 D transposase for insertion sequence element IS1533 3235280..3236521 Mycobacterium bovis BCG str. Tokyo 172 7564492 YP_002646007.1 CDS JTY_2961 NC_012207.1 3236521 3237051 D transposase 3236521..3237051 Mycobacterium bovis BCG str. Tokyo 172 7563825 YP_002646008.1 CDS lppX NC_012207.1 3237440 3238141 R lipoprotein complement(3237440..3238141) Mycobacterium bovis BCG str. Tokyo 172 7563826 YP_002646009.1 CDS pks1 NC_012207.1 3238490 3244828 R In Mycobacterium tuberculosis H37Rv, pks1 and pks15 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-G) results in a single product that is more similar to pks1. Differs from Rv2946c by 2aa, G1779V, V1859A, and from Rv2947c by 2aa, A333V, R374G in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo.; polyketide synthase complement(3238490..3244828) Mycobacterium bovis BCG str. Tokyo 172 7560490 YP_002646010.1 CDS fadD22 NC_012207.1 3244825 3246942 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(3244825..3246942) Mycobacterium bovis BCG str. Tokyo 172 7562440 YP_002646011.1 CDS JTY_2965 NC_012207.1 3246959 3247558 R hypothetical protein complement(3246959..3247558) Mycobacterium bovis BCG str. Tokyo 172 7562928 YP_002646012.1 CDS fadD29 NC_012207.1 3247584 3249443 R activates fatty acids by binding to coenzyme A; acyl-CoA synthetase complement(3247584..3249443) Mycobacterium bovis BCG str. Tokyo 172 7563827 YP_002646013.1 CDS JTY_2967 NC_012207.1 3250091 3251236 R oxidoreductase complement(3250091..3251236) Mycobacterium bovis BCG str. Tokyo 172 7562934 YP_002646014.1 CDS JTY_2968 NC_012207.1 3251429 3252241 D methyltransferase 3251429..3252241 Mycobacterium bovis BCG str. Tokyo 172 7563828 YP_002646015.1 CDS JTY_2969 NC_012207.1 3252267 3253523 D hypothetical protein 3252267..3253523 Mycobacterium bovis BCG str. Tokyo 172 7563829 YP_002646016.1 CDS JTY_2970 NC_012207.1 3253654 3254379 R Differs from Rv2954c and Mb2978c by 1aa, Q194R in BCG Pasteur and BCG Tokyo; hypothetical protein complement(3253654..3254379) Mycobacterium bovis BCG str. Tokyo 172 7563830 YP_002646017.1 CDS JTY_2971 NC_012207.1 3254568 3255533 R Differs from Rv2955c by 1aa, H27R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3254568..3255533) Mycobacterium bovis BCG str. Tokyo 172 7563831 YP_002646018.1 CDS JTY_2972 NC_012207.1 3255656 3256387 D Differs from Rv2956 by 1aa, T237I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3255656..3256387 Mycobacterium bovis BCG str. Tokyo 172 7563832 YP_002646019.1 CDS JTY_2973 NC_012207.1 3256458 3257285 D glycosyl transferase 3256458..3257285 Mycobacterium bovis BCG str. Tokyo 172 7563833 YP_002646020.1 CDS JTY_2974 NC_012207.1 3257889 3258989 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base insertion (*-g) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; glycosyl transferase complement(3257889..3258989) Mycobacterium bovis BCG str. Tokyo 172 7563834 YP_002646021.1 CDS JTY_2975 NC_012207.1 3259090 3259827 R methyltransferase complement(3259090..3259827) Mycobacterium bovis BCG str. Tokyo 172 7563835 YP_002646022.1 CDS JTY_2976 NC_012207.1 3259942 3260190 R hypothetical protein complement(3259942..3260190) Mycobacterium bovis BCG str. Tokyo 172 7563836 YP_002646023.1 CDS JTY_2977 NC_012207.1 3260272 3260661 D transposase 3260272..3260661 Mycobacterium bovis BCG str. Tokyo 172 7563837 YP_002646024.1 CDS JTY_2978 NC_012207.1 3260762 3262111 R glycosyl transferase complement(3260762..3262111) Mycobacterium bovis BCG str. Tokyo 172 7563838 YP_002646025.1 CDS JTY_2979 NC_012207.1 3262225 3263445 D integral membrane protein 3262225..3263445 Mycobacterium bovis BCG str. Tokyo 172 7563839 YP_002646026.1 CDS purU NC_012207.1 3263518 3264450 D produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 3263518..3264450 Mycobacterium bovis BCG str. Tokyo 172 7562692 YP_002646027.1 CDS coaD NC_012207.1 3265319 3265804 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(3265319..3265804) Mycobacterium bovis BCG str. Tokyo 172 7560867 YP_002646028.1 CDS JTY_2982 NC_012207.1 3265890 3266456 R methyltransferase complement(3265890..3266456) Mycobacterium bovis BCG str. Tokyo 172 7561789 YP_002646029.1 CDS pca NC_012207.1 3266652 3270035 R biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate; pyruvate carboxylase complement(3266652..3270035) Mycobacterium bovis BCG str. Tokyo 172 7562693 YP_002646030.1 CDS JTY_2984 NC_012207.1 3270060 3270692 R integral membrane protein complement(3270060..3270692) Mycobacterium bovis BCG str. Tokyo 172 7562520 YP_002646031.1 CDS JTY_2985 NC_012207.1 3270698 3271465 R membrane or hypothetical protein complement(3270698..3271465) Mycobacterium bovis BCG str. Tokyo 172 7562694 YP_002646032.1 CDS lipN NC_012207.1 3271562 3272692 R lipase/esterase complement(3271562..3272692) Mycobacterium bovis BCG str. Tokyo 172 7562695 YP_002646033.1 CDS JTY_2987 NC_012207.1 3272923 3273093 D hypothetical protein 3272923..3273093 Mycobacterium bovis BCG str. Tokyo 172 7562841 YP_002646034.1 CDS JTY_2988 NC_012207.1 3273090 3273938 D Differs from Rv2971 by 1aa, H152N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 3273090..3273938 Mycobacterium bovis BCG str. Tokyo 172 7562696 YP_002646035.1 CDS JTY_2989 NC_012207.1 3274012 3274725 R membrane or exported protein complement(3274012..3274725) Mycobacterium bovis BCG str. Tokyo 172 7562697 YP_002646036.1 CDS recG NC_012207.1 3274722 3276935 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(3274722..3276935) Mycobacterium bovis BCG str. Tokyo 172 7562698 YP_002646037.1 CDS JTY_2991 NC_012207.1 3276938 3278599 R In Mycobacterium tuberculosis H37Rv, Rv2975c and Rv2974c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 2 bp deletion (CG-*) results in a single product that is more similar to Rv2974c; hypothetical alanine rich protein complement(3276938..3278599) Mycobacterium bovis BCG str. Tokyo 172 7561559 YP_002646038.1 CDS ung NC_012207.1 3279058 3279741 R Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase complement(3279058..3279741) Mycobacterium bovis BCG str. Tokyo 172 7562699 YP_002646039.1 CDS thiL NC_012207.1 3279774 3280775 R catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase complement(3279774..3280775) Mycobacterium bovis BCG str. Tokyo 172 7561658 YP_002646040.1 CDS JTY_2994 NC_012207.1 3280772 3282151 R transposase complement(3280772..3282151) Mycobacterium bovis BCG str. Tokyo 172 7561846 YP_002646041.1 CDS JTY_2995 NC_012207.1 3282151 3282735 R Differs from Rv2979c by 3aa, R14P, A79T, G151D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; resolvase complement(3282151..3282735) Mycobacterium bovis BCG str. Tokyo 172 7562700 YP_002646042.1 CDS JTY_2996 NC_012207.1 3282947 3283492 D hypothetical protein 3282947..3283492 Mycobacterium bovis BCG str. Tokyo 172 7562701 YP_002646043.1 CDS ddl NC_012207.1 3283960 3285081 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(3283960..3285081) Mycobacterium bovis BCG str. Tokyo 172 7562702 YP_002646044.1 CDS gpsA NC_012207.1 3285159 3286163 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(3285159..3286163) Mycobacterium bovis BCG str. Tokyo 172 7561472 YP_002646045.1 CDS JTY_2999 NC_012207.1 3286282 3286926 D hypothetical alanine rich protein 3286282..3286926 Mycobacterium bovis BCG str. Tokyo 172 7563277 YP_002646046.1 CDS ppk NC_012207.1 3287018 3289246 D catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 3287018..3289246 Mycobacterium bovis BCG str. Tokyo 172 7562703 YP_002646047.1 CDS mutT1 NC_012207.1 3289329 3290282 D hydrolase 3289329..3290282 Mycobacterium bovis BCG str. Tokyo 172 7560808 YP_002646048.1 CDS hupB NC_012207.1 3290340 3290957 R Differs from Rv2986c and Mb3010c by 9aa deletion atposition 137 in BCG Pasteur and BCG Tokyo; DNA-binding protein HU homolog complement(3290340..3290957) Mycobacterium bovis BCG str. Tokyo 172 7563581 YP_002646049.1 CDS leuD NC_012207.1 3291170 3291766 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(3291170..3291766) Mycobacterium bovis BCG str. Tokyo 172 7563334 YP_002646050.1 CDS leuC NC_012207.1 3291791 3293212 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(3291791..3293212) Mycobacterium bovis BCG str. Tokyo 172 7562816 YP_002646051.1 CDS JTY_3005 NC_012207.1 3293284 3293985 D transcriptional regulatory protein 3293284..3293985 Mycobacterium bovis BCG str. Tokyo 172 7562815 YP_002646052.1 CDS JTY_3006 NC_012207.1 3293996 3294856 R Differs from Mb3014c by 1aa, A217E in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3293996..3294856) Mycobacterium bovis BCG str. Tokyo 172 7562704 YP_002646053.1 CDS JTY_3007 NC_012207.1 3295119 3295610 D Differs from Rv2991 by 1aa, T93A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3295119..3295610 Mycobacterium bovis BCG str. Tokyo 172 7562705 YP_002646054.1 CDS gltX NC_012207.1 3295942 3297414 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(3295942..3297414) Mycobacterium bovis BCG str. Tokyo 172 7561936 YP_002646055.1 CDS JTY_3009 NC_012207.1 3297411 3298130 R 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase complement(3297411..3298130) Mycobacterium bovis BCG str. Tokyo 172 7561949 YP_002646056.1 CDS JTY_3010 NC_012207.1 3298406 3299743 D integral membrane protein 3298406..3299743 Mycobacterium bovis BCG str. Tokyo 172 7562707 YP_002646057.1 CDS leuB NC_012207.1 3299595 3300605 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(3299595..3300605) Mycobacterium bovis BCG str. Tokyo 172 7562708 YP_002646058.1 CDS serA1 NC_012207.1 3300620 3302206 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(3300620..3302206) Mycobacterium bovis BCG str. Tokyo 172 7562814 YP_002646059.1 CDS JTY_3013 NC_012207.1 3302236 3303678 D Differs from Rv2997 by 1aa S108C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; alanine rich dehydrogenase 3302236..3303678 Mycobacterium bovis BCG str. Tokyo 172 7560779 YP_002646060.1 CDS JTY_3014 NC_012207.1 3303952 3304413 D hypothetical protein 3303952..3304413 Mycobacterium bovis BCG str. Tokyo 172 7562709 YP_002646061.1 CDS JTY_3015 NC_012207.1 3304362 3304565 R hypothetical protein complement(3304362..3304565) Mycobacterium bovis BCG str. Tokyo 172 7562710 YP_002646062.1 CDS lppY NC_012207.1 3304739 3305704 D Differs from Rv2999 by 1aa, L212M in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 3304739..3305704 Mycobacterium bovis BCG str. Tokyo 172 7562711 YP_002646063.1 CDS JTY_3017 NC_012207.1 3305749 3306408 D transmembrane protein 3305749..3306408 Mycobacterium bovis BCG str. Tokyo 172 7560491 YP_002646064.1 CDS ilvC NC_012207.1 3306722 3307723 R catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase complement(3306722..3307723) Mycobacterium bovis BCG str. Tokyo 172 7562712 YP_002646065.1 CDS ilvH NC_012207.1 3307761 3308267 R with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit complement(3307761..3308267) Mycobacterium bovis BCG str. Tokyo 172 7562778 YP_002646066.1 CDS ilvB1 NC_012207.1 3308267 3310123 R acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 1 catalytic subunit complement(3308267..3310123) Mycobacterium bovis BCG str. Tokyo 172 7562782 YP_002646067.1 CDS cfp6 NC_012207.1 3310485 3310823 D low molecular weight protein antigen 6 3310485..3310823 Mycobacterium bovis BCG str. Tokyo 172 7562776 YP_002646068.1 CDS JTY_3022 NC_012207.1 3310830 3311669 R hypothetical protein complement(3310830..3311669) Mycobacterium bovis BCG str. Tokyo 172 7562101 YP_002646069.1 CDS lppZ NC_012207.1 3311846 3312967 D Differs from Rv3006 by 1aa, D219G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 3311846..3312967 Mycobacterium bovis BCG str. Tokyo 172 7562713 YP_002646070.1 CDS JTY_3024 NC_012207.1 3312973 3313587 R oxidoreductase complement(3312973..3313587) Mycobacterium bovis BCG str. Tokyo 172 7560492 YP_002646071.1 CDS JTY_3025 NC_012207.1 3313781 3314404 D hypothetical protein 3313781..3314404 Mycobacterium bovis BCG str. Tokyo 172 7562714 YP_002646072.1 CDS gatB NC_012207.1 3314401 3315930 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(3314401..3315930) Mycobacterium bovis BCG str. Tokyo 172 7562715 YP_002646073.1 CDS pfkA NC_012207.1 3315960 3316991 R catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase complement(3315960..3316991) Mycobacterium bovis BCG str. Tokyo 172 7561904 YP_002646074.1 CDS gatA NC_012207.1 3317087 3318571 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(3317087..3318571) Mycobacterium bovis BCG str. Tokyo 172 7562395 YP_002646075.1 CDS gatC NC_012207.1 3318568 3318867 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C complement(3318568..3318867) Mycobacterium bovis BCG str. Tokyo 172 7561903 YP_002646076.1 CDS JTY_3030 NC_012207.1 3318952 3319608 D hypothetical protein 3318952..3319608 Mycobacterium bovis BCG str. Tokyo 172 7561905 YP_002646077.1 CDS ligA NC_012207.1 3319682 3321757 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(3319682..3321757) Mycobacterium bovis BCG str. Tokyo 172 7562716 YP_002646078.1 CDS JTY_3032 NC_012207.1 3321788 3322801 R hypothetical protein complement(3321788..3322801) Mycobacterium bovis BCG str. Tokyo 172 7562826 YP_002646079.1 CDS lpqA NC_012207.1 3322895 3323524 D lipoprotein 3322895..3323524 Mycobacterium bovis BCG str. Tokyo 172 7562717 YP_002646080.1 CDS esxQ NC_012207.1 3323627 3323989 R EsaT-6 like protein 8 complement(3323627..3323989) Mycobacterium bovis BCG str. Tokyo 172 7560493 YP_002646081.1 CDS PPE46 NC_012207.1 3324076 3325389 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a 56 bp deletion leads to a products lightly different at the N-terminus part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (434 aa versus 437 aa). Differs from Rv3018c by 1aa, A53V, and Mb3043c by 1aa, L328V in BCG Pasteur, and BCG Tokyo; PPE family protein complement(3324076..3325389) Mycobacterium bovis BCG str. Tokyo 172 7562887 YP_002646083.1 CDS esxR NC_012207.1 3325792 3326082 R EsaT-6 like protein 9 complement(3325792..3326082) Mycobacterium bovis BCG str. Tokyo 172 7561728 YP_002646084.1 CDS esxS NC_012207.1 3326117 3326410 R PE family protein complement(3326117..3326410) Mycobacterium bovis BCG str. Tokyo 172 7562888 YP_002646085.1 CDS PPE47 NC_012207.1 3326457 3327764 R In Mycobacterium tuberculosis H37Rv, PPE47 and PPE48 exist as 2 separate genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-G) leads to a single product.; PPE family protein complement(3326457..3327764) Mycobacterium bovis BCG str. Tokyo 172 7562889 YP_002646086.1 CDS PE29 NC_012207.1 3327761 3328075 R PE family protein complement(3327761..3328075) Mycobacterium bovis BCG str. Tokyo 172 7562185 YP_002646087.1 CDS JTY_3041 NC_012207.1 3328457 3329704 R Differs from Rv3023c by 1aa T9A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transposase complement(3328457..3329704) Mycobacterium bovis BCG str. Tokyo 172 7561729 YP_002646088.1 CDS mnmA NC_012207.1 3329867 3330970 R catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA complement(3329867..3330970) Mycobacterium bovis BCG str. Tokyo 172 7562718 YP_002646089.1 CDS iscS NC_012207.1 3330967 3332148 R cysteine desulfurase complement(3330967..3332148) Mycobacterium bovis BCG str. Tokyo 172 7561627 YP_002646090.1 CDS JTY_3044 NC_012207.1 3332245 3333159 R hypothetical protein complement(3332245..3333159) Mycobacterium bovis BCG str. Tokyo 172 7562793 YP_002646091.1 CDS JTY_3045 NC_012207.1 3333156 3333896 R hypothetical protein complement(3333156..3333896) Mycobacterium bovis BCG str. Tokyo 172 7562719 YP_002646092.1 CDS fixB NC_012207.1 3334157 3335113 R Differs from Rv3028c by 1aa, V312A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; electron transfer flavoprotein alpha-subunit complement(3334157..3335113) Mycobacterium bovis BCG str. Tokyo 172 7562720 YP_002646093.1 CDS fixA NC_012207.1 3335152 3335952 R electron transfer flavoprotein beta-subunit complement(3335152..3335952) Mycobacterium bovis BCG str. Tokyo 172 7563416 YP_002646094.1 CDS JTY_3048 NC_012207.1 3336183 3337007 D hypothetical protein 3336183..3337007 Mycobacterium bovis BCG str. Tokyo 172 7563415 YP_002646095.1 CDS JTY_3049 NC_012207.1 3337004 3338584 D hypothetical protein 3337004..3338584 Mycobacterium bovis BCG str. Tokyo 172 7562721 YP_002646096.1 CDS JTY_3050 NC_012207.1 3338616 3339860 D Differs from Rv3032 and Mb3058 by 1aa, P380Q in BCG Pasteur and BCG Tokyo; transferase 3338616..3339860 Mycobacterium bovis BCG str. Tokyo 172 7562722 YP_002646097.1 CDS JTY_3051 NC_012207.1 3339894 3340283 D hypothetical protein 3339894..3340283 Mycobacterium bovis BCG str. Tokyo 172 7562723 YP_002646098.1 CDS JTY_3052 NC_012207.1 3340462 3341010 D hypothetical protein 3340462..3341010 Mycobacterium bovis BCG str. Tokyo 172 7562724 YP_002646099.1 CDS JTY_3053 NC_012207.1 3341101 3342003 R transferase complement(3341101..3342003) Mycobacterium bovis BCG str. Tokyo 172 7562725 YP_002646100.1 CDS JTY_3054 NC_012207.1 3342461 3343543 D hypothetical protein 3342461..3343543 Mycobacterium bovis BCG str. Tokyo 172 7562726 YP_002646101.1 CDS TB22.2 NC_012207.1 3343540 3344223 R Differs from Mb3062c by 1aa, Q63R in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3343540..3344223) Mycobacterium bovis BCG str. Tokyo 172 7562727 YP_002646102.1 CDS JTY_3056 NC_012207.1 3344296 3345372 R Differs from Rv3037c by 1aa, A7D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3344296..3345372) Mycobacterium bovis BCG str. Tokyo 172 7561832 YP_002646103.1 CDS JTY_3057 NC_012207.1 3345507 3346490 R hypothetical protein complement(3345507..3346490) Mycobacterium bovis BCG str. Tokyo 172 7562728 YP_002646104.1 CDS echA17 NC_012207.1 3346501 3347265 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(3346501..3347265) Mycobacterium bovis BCG str. Tokyo 172 7562729 YP_002646105.1 CDS JTY_3059 NC_012207.1 3347274 3348140 R hypothetical protein complement(3347274..3348140) Mycobacterium bovis BCG str. Tokyo 172 7561528 YP_002646106.1 CDS JTY_3060 NC_012207.1 3348137 3349000 R ATP-binding protein ABC transporter complement(3348137..3349000) Mycobacterium bovis BCG str. Tokyo 172 7562730 YP_002646107.1 CDS serB2 NC_012207.1 3349015 3350244 R Differs from Rv3042c by 2aa, S70A, E116G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; phosphoserine phosphatase complement(3349015..3350244) Mycobacterium bovis BCG str. Tokyo 172 7562731 YP_002646108.1 CDS ctaD NC_012207.1 3350282 3352003 R cytochrome c oxidase polypeptide I complement(3350282..3352003) Mycobacterium bovis BCG str. Tokyo 172 7560782 YP_002646109.1 CDS fecB NC_012207.1 3352218 3353297 D FeIII-dicitrate-binding periplasmic lipoprotein 3352218..3353297 Mycobacterium bovis BCG str. Tokyo 172 7563129 YP_002646110.1 CDS adhC NC_012207.1 3353367 3354407 D NADP-dependent alcohol dehydrogenase 3353367..3354407 Mycobacterium bovis BCG str. Tokyo 172 7563410 YP_002646111.1 CDS JTY_3065 NC_012207.1 3354396 3354770 R hypothetical protein complement(3354396..3354770) Mycobacterium bovis BCG str. Tokyo 172 7563943 YP_002646112.1 CDS JTY_3066 NC_012207.1 3355104 3355388 R hypothetical protein complement(3355104..3355388) Mycobacterium bovis BCG str. Tokyo 172 7562732 YP_002646113.1 CDS nrdF2 NC_012207.1 3355486 3356460 R ribonucleotide-diphosphate reductase subunit beta complement(3355486..3356460) Mycobacterium bovis BCG str. Tokyo 172 7562733 YP_002646114.1 CDS JTY_3068 NC_012207.1 3356591 3358165 R monooxygenase complement(3356591..3358165) Mycobacterium bovis BCG str. Tokyo 172 7562467 YP_002646115.1 CDS JTY_3069 NC_012207.1 3358299 3359039 R probably AsnC-family; transcriptional regulatory protein complement(3358299..3359039) Mycobacterium bovis BCG str. Tokyo 172 7562734 YP_002646116.1 CDS nrdE NC_012207.1 3359167 3361248 R Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha complement(3359167..3361248) Mycobacterium bovis BCG str. Tokyo 172 7562735 YP_002646117.1 CDS nrdI NC_012207.1 3361314 3361766 R in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein complement(3361314..3361766) Mycobacterium bovis BCG str. Tokyo 172 7562465 YP_002646118.1 CDS nrdH NC_012207.1 3361801 3362040 R glutaredoxin-like protein; glutaredoxin electron transport component of nrdEF complement(3361801..3362040) Mycobacterium bovis BCG str. Tokyo 172 7562469 YP_002646119.1 CDS JTY_3073 NC_012207.1 3362018 3362386 R hypothetical protein complement(3362018..3362386) Mycobacterium bovis BCG str. Tokyo 172 7562468 YP_002646120.1 CDS JTY_3074 NC_012207.1 3362503 3363057 R hypothetical protein complement(3362503..3363057) Mycobacterium bovis BCG str. Tokyo 172 7562736 YP_002646121.1 CDS JTY_3075 NC_012207.1 3363149 3363763 D probably TetR-family; transcriptional regulatory protein 3363149..3363763 Mycobacterium bovis BCG str. Tokyo 172 7562737 YP_002646122.1 CDS dinP NC_012207.1 3363773 3364813 D involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 3363773..3364813 Mycobacterium bovis BCG str. Tokyo 172 7562738 YP_002646123.1 CDS JTY_3077 NC_012207.1 3364867 3365730 R short chain dehydrogenase complement(3364867..3365730) Mycobacterium bovis BCG str. Tokyo 172 7561495 YP_002646124.1 CDS JTY_3078 NC_012207.1 3365794 3366444 R probably TetR-family; transcriptional regulatory protein complement(3365794..3366444) Mycobacterium bovis BCG str. Tokyo 172 7562739 YP_002646125.1 CDS cyp136 NC_012207.1 3366560 3368038 D Differs from Mb3085 by 1aa, E44K and Rv3059 by 2aa, E44K, G445D in BCG Pasteur and BCG Tokyo; cytochrome P450 136 3366560..3368038 Mycobacterium bovis BCG str. Tokyo 172 7562740 YP_002646126.1 CDS JTY_3080 NC_012207.1 3368809 3370281 R probably GntR-family; transcriptional regulatory protein complement(3368809..3370281) Mycobacterium bovis BCG str. Tokyo 172 7563162 YP_002646127.1 CDS fadE22 NC_012207.1 3370398 3372563 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium tuberculosis strain H37Rv, fadE22 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-C) splits fadE22 into 2 parts, fadE22a and fadE22b. Differs from Mb3087c and from Rv3061c by 2aa, E488K, C497S in BCG Pasteur and BCG Tokyo; acyl-CoA dehydrogenase complement(3370398..3372563) Mycobacterium bovis BCG str. Tokyo 172 7562741 YP_002646128.1 CDS ligB NC_012207.1 3372720 3374243 D catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; ATP-dependent DNA ligase 3372720..3374243 Mycobacterium bovis BCG str. Tokyo 172 7563371 YP_002646129.1 CDS cstA NC_012207.1 3374379 3376655 D Differs from Rv3063 by 3aa, C402G, S559R, P600L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; carbon starvation protein A homolog 3374379..3376655 Mycobacterium bovis BCG str. Tokyo 172 7562827 YP_002646130.1 CDS JTY_3084 NC_012207.1 3376961 3377386 R integral membrane protein complement(3376961..3377386) Mycobacterium bovis BCG str. Tokyo 172 7563126 YP_002646131.1 CDS mmr NC_012207.1 3377523 3377846 D multidrug-transport integral membrane protein 3377523..3377846 Mycobacterium bovis BCG str. Tokyo 172 7562742 YP_002646132.1 CDS JTY_3086 NC_012207.1 3377843 3378451 D probably DeoR-family; transcriptional regulatory protein 3377843..3378451 Mycobacterium bovis BCG str. Tokyo 172 7563517 YP_002646133.1 CDS JTY_3087 NC_012207.1 3378564 3378974 D Differs from Rv3067 and Mb3094 by 1aa A3T in BCG Pasteur and BCG Tokyo; hypothetical protein 3378564..3378974 Mycobacterium bovis BCG str. Tokyo 172 7562743 YP_002646134.1 CDS pgmA NC_012207.1 3379115 3380758 R catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase complement(3379115..3380758) Mycobacterium bovis BCG str. Tokyo 172 7563956 YP_002646135.1 CDS JTY_3089 NC_012207.1 3380828 3381226 D may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 3380828..3381226 Mycobacterium bovis BCG str. Tokyo 172 7562400 YP_002646136.1 CDS JTY_3090 NC_012207.1 3381223 3381603 D may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 3381223..3381603 Mycobacterium bovis BCG str. Tokyo 172 7562745 YP_002646137.1 CDS JTY_3091 NC_012207.1 3381600 3382709 D hypothetical protein 3381600..3382709 Mycobacterium bovis BCG str. Tokyo 172 7562746 YP_002646138.1 CDS JTY_3092 NC_012207.1 3382934 3383458 R hypothetical protein complement(3382934..3383458) Mycobacterium bovis BCG str. Tokyo 172 7562747 YP_002646139.1 CDS JTY_3093 NC_012207.1 3383465 3383821 R hypothetical protein complement(3383465..3383821) Mycobacterium bovis BCG str. Tokyo 172 7562748 YP_002646140.1 CDS JTY_3094 NC_012207.1 3383915 3385189 D hypothetical protein 3383915..3385189 Mycobacterium bovis BCG str. Tokyo 172 7562749 YP_002646141.1 CDS JTY_3095 NC_012207.1 3385186 3386109 R hypothetical protein complement(3385186..3386109) Mycobacterium bovis BCG str. Tokyo 172 7562750 YP_002646142.1 CDS JTY_3096 NC_012207.1 3386208 3386684 D hypothetical protein 3386208..3386684 Mycobacterium bovis BCG str. Tokyo 172 7562751 YP_002646143.1 CDS JTY_3097 NC_012207.1 3386677 3388488 D Differs from Rv3077 by 1aa R311G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrolase 3386677..3388488 Mycobacterium bovis BCG str. Tokyo 172 7562752 YP_002646144.1 CDS hab NC_012207.1 3388489 3388890 D hydroxylaminobenzene mutase 3388489..3388890 Mycobacterium bovis BCG str. Tokyo 172 7562753 YP_002646145.1 CDS JTY_3099 NC_012207.1 3388906 3389733 R hypothetical protein complement(3388906..3389733) Mycobacterium bovis BCG str. Tokyo 172 7563293 YP_002646146.1 CDS pknK NC_012207.1 3389792 3393124 R Differs from Rv3080c by 1aa, V217A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; serine/threonine-protein kinase transcriptional regulatory protein complement(3389792..3393124) Mycobacterium bovis BCG str. Tokyo 172 7562754 YP_002646147.1 CDS JTY_3101 NC_012207.1 3393176 3394414 D Differs from Rv3081 and Mb3108 by 1aa, A108V in BCG Pasteur and BCG Tokyo; hypothetical protein 3393176..3394414 Mycobacterium bovis BCG str. Tokyo 172 7562438 YP_002646148.1 CDS virS NC_012207.1 3394540 3395562 R AraC/XylS family; Differs from Rv3082c by 1aa, C322R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; virulence-regulating transcriptional regulator complement(3394540..3395562) Mycobacterium bovis BCG str. Tokyo 172 7562755 YP_002646149.1 CDS JTY_3103 NC_012207.1 3395640 3397127 D Differs from Mb3110 by 1aa, S81I and from Rv3083 by 2aa, S81I, I94V in BCG Pasteur and BCG Tokyo; monooxygenase 3395640..3397127 Mycobacterium bovis BCG str. Tokyo 172 7561681 YP_002646150.1 CDS lipR NC_012207.1 3397133 3398059 D Differs from Rv3084 and Mb3111 by 1aa, G276S in BCG Pasteur and BCG Tokyo; acetyl-hydrolase/esterase 3397133..3398059 Mycobacterium bovis BCG str. Tokyo 172 7562756 YP_002646151.1 CDS JTY_3105 NC_012207.1 3398056 3398886 D short-chain type dehydrogenase/reductase 3398056..3398886 Mycobacterium bovis BCG str. Tokyo 172 7562845 YP_002646152.1 CDS adhD NC_012207.1 3398917 3400023 D zinc-type alcohol dehydrogenase 3398917..3400023 Mycobacterium bovis BCG str. Tokyo 172 7562757 YP_002646153.1 CDS JTY_3107 NC_012207.1 3400061 3401479 D Differs from Rv3087 by 1aa, V447L, and from Mb3114 by 1aa, T158A in BCG Pasteur and BCG Tokyo; hypothetical protein 3400061..3401479 Mycobacterium bovis BCG str. Tokyo 172 7563944 YP_002646154.1 CDS JTY_3108 NC_012207.1 3401476 3402900 D hypothetical protein 3401476..3402900 Mycobacterium bovis BCG str. Tokyo 172 7562758 YP_002646155.1 CDS fadD13 NC_012207.1 3402897 3404408 D chain-fatty-acid-CoA ligase 3402897..3404408 Mycobacterium bovis BCG str. Tokyo 172 7562759 YP_002646156.1 CDS JTY_3110 NC_012207.1 3405347 3406234 D hypothetical alanine and valine rich protein 3405347..3406234 Mycobacterium bovis BCG str. Tokyo 172 7562919 YP_002646157.1 CDS JTY_3111 NC_012207.1 3406252 3407943 D hypothetical protein 3406252..3407943 Mycobacterium bovis BCG str. Tokyo 172 7562760 YP_002646158.1 CDS JTY_3112 NC_012207.1 3407950 3408870 R Differs from Mb3119c by 1 aa, I237M in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein complement(3407950..3408870) Mycobacterium bovis BCG str. Tokyo 172 7562761 YP_002646159.1 CDS JTY_3113 NC_012207.1 3408896 3409900 R Differs from Rv3093c by 1aa W210C in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; oxidoreductase complement(3408896..3409900) Mycobacterium bovis BCG str. Tokyo 172 7562762 YP_002646160.1 CDS JTY_3114 NC_012207.1 3409897 3411027 R hypothetical protein complement(3409897..3411027) Mycobacterium bovis BCG str. Tokyo 172 7562763 YP_002646161.1 CDS JTY_3115 NC_012207.1 3411109 3411585 D hypothetical transcriptional regulatory protein 3411109..3411585 Mycobacterium bovis BCG str. Tokyo 172 7562764 YP_002646162.1 CDS JTY_3116 NC_012207.1 3411683 3412822 D Differs from Rv3097 by 1aa G28E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3411683..3412822 Mycobacterium bovis BCG str. Tokyo 172 7562765 YP_002646163.1 CDS PE_PGRS63 NC_012207.1 3412914 3414227 R Differs from Rv3097c by 1aa A58G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably triacyl glycerol lipase; PE-PGRS family protein complement(3412914..3414227) Mycobacterium bovis BCG str. Tokyo 172 7562766 YP_002646164.1 CDS JTY_3118 NC_012207.1 3414346 3414798 R Differs from Rv3098c by 1aa E117D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3414346..3414798) Mycobacterium bovis BCG str. Tokyo 172 7562389 YP_002646165.1 CDS JTY_3119 NC_012207.1 3415549 3416400 R hypothetical protein complement(3415549..3416400) Mycobacterium bovis BCG str. Tokyo 172 7564321 YP_002646166.1 CDS smpB NC_012207.1 3416437 3416919 R binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein complement(3416437..3416919) Mycobacterium bovis BCG str. Tokyo 172 7562768 YP_002646167.1 CDS ftsX NC_012207.1 3416922 3417815 R Differs from Rv3101c by 1aa, S171N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cell division protein complement(3416922..3417815) Mycobacterium bovis BCG str. Tokyo 172 7561801 YP_002646168.1 CDS ftsE NC_012207.1 3417816 3418505 R cell division ATP-binding protein complement(3417816..3418505) Mycobacterium bovis BCG str. Tokyo 172 7561881 YP_002646169.1 CDS JTY_3123 NC_012207.1 3418549 3418986 R hypothetical protein complement(3418549..3418986) Mycobacterium bovis BCG str. Tokyo 172 7561876 YP_002646170.1 CDS JTY_3124 NC_012207.1 3418988 3419914 R transmembrane protein complement(3418988..3419914) Mycobacterium bovis BCG str. Tokyo 172 7562769 YP_002646171.1 CDS prfB NC_012207.1 3419904 3421040 R recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 complement(3419904..3421040) Mycobacterium bovis BCG str. Tokyo 172 7562770 YP_002646172.1 CDS fprA NC_012207.1 3421144 3422514 D Differs from Rv3106 by 2aa, I141V, D385N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; NADPH:adrenodoxin oxidoreductase 3421144..3422514 Mycobacterium bovis BCG str. Tokyo 172 7560822 YP_002646173.1 CDS agpS NC_012207.1 3422515 3424098 R alkyldihydroxyacetonephosphate synthase complement(3422515..3424098) Mycobacterium bovis BCG str. Tokyo 172 7563427 YP_002646174.1 CDS JTY_3128 NC_012207.1 3424197 3424637 D Differs from Mb3135 by 1aa I145V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3424197..3424637 Mycobacterium bovis BCG str. Tokyo 172 7563950 YP_002646175.1 CDS moaA1 NC_012207.1 3424786 3425865 D Differs from Mb3136 by 1aa, T324A in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; molybdenum cofactor biosynthesis protein A 3424786..3425865 Mycobacterium bovis BCG str. Tokyo 172 7562771 YP_002646176.1 CDS moaB1 NC_012207.1 3425916 3426311 D pterin-4-alpha-carbinolamine dehydratase 3425916..3426311 Mycobacterium bovis BCG str. Tokyo 172 7563523 YP_002646177.1 CDS moaC NC_012207.1 3426308 3426820 D MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 3426308..3426820 Mycobacterium bovis BCG str. Tokyo 172 7563525 YP_002646178.1 CDS moaD1 NC_012207.1 3426837 3427088 D molybdenum cofactor biosynthesis protein D 3426837..3427088 Mycobacterium bovis BCG str. Tokyo 172 7563528 YP_002646179.1 CDS JTY_3133 NC_012207.1 3427210 3427878 D Differs from Rv3113 by 3aa, C11W, E134G, R191L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; phosphatase 3427210..3427878 Mycobacterium bovis BCG str. Tokyo 172 7563531 YP_002646180.1 CDS JTY_3134 NC_012207.1 3427895 3428425 D Differs from Rv3114 by 1aa, P11S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3427895..3428425 Mycobacterium bovis BCG str. Tokyo 172 7562772 YP_002646181.1 CDS JTY_3135 NC_012207.1 3428587 3429834 D transposase 3428587..3429834 Mycobacterium bovis BCG str. Tokyo 172 7562773 YP_002646182.1 CDS moeB2 NC_012207.1 3429912 3431081 D molybdenum cofactor biosynthesis protein 3429912..3431081 Mycobacterium bovis BCG str. Tokyo 172 7561286 YP_002646183.1 CDS cysA3 NC_012207.1 3431110 3432072 D In Mycobacterium bovis BCG Pasteur, and Mycobacterium bovis, a large deletion of 2775 bp (RD12) leads to the loss of the COOH part of cysA3, the following CDSs, sseC1, moaE1, Rv3120 and a large part of cyp141 except the COOH end, compared to the homolog in Mycobacterium tuberculosis strain H37Rv; thiosulfate sulfurtransferase 3431110..3432072 Mycobacterium bovis BCG str. Tokyo 172 7563542 YP_002646184.1 CDS JTY_3138 NC_012207.1 3432450 3432920 D Differs from Rv3122 by 1aa, S156R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3432450..3432920 Mycobacterium bovis BCG str. Tokyo 172 7563174 YP_002646185.1 CDS JTY_3139 NC_012207.1 3432930 3433424 D Differs from Rv3123 by 1aa, Q40R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3432930..3433424 Mycobacterium bovis BCG str. Tokyo 172 7561287 YP_002646186.1 CDS JTY_3140 NC_012207.1 3433867 3434736 D Differs from Rv3124 and Mb3147 by 1aa, G159E in BCG Pasteur and BCG Tokyo; transcriptional regulatory protein 3433867..3434736 Mycobacterium bovis BCG str. Tokyo 172 7561288 YP_002646187.1 CDS PPE49b NC_012207.1 3434837 3435151 R In Mycobacterium bovis BCG Pasteur and BCG Tokyo, PPE49 has incurred a single base deletion in codon 272 compared to Rv3125c and Mb3148c leading to frameshift, and two products of 282 and 104 aa, compared to 391 in others; PPE family protein complement(3434837..3435151) Mycobacterium bovis BCG str. Tokyo 172 7561289 YP_002646188.1 CDS PPE49a NC_012207.1 3435163 3436011 R In Mycobacterium bovis BCG Pasteur and BCG Tokyo, PPE49 has incurred a single base deletion in codon 272 compared to Rv3125c and Mb3148c leading to frameshift, and two products of 282 and 104 aa, compared to 391 in others. Differs from Rv3125c by 1aa, V38A; PPE family protein complement(3435163..3436011) Mycobacterium bovis BCG str. Tokyo 172 7562187 YP_002646189.1 CDS JTY_3143 NC_012207.1 3436168 3436482 R hypothetical protein complement(3436168..3436482) Mycobacterium bovis BCG str. Tokyo 172 7562186 YP_002646190.1 CDS JTY_3144 NC_012207.1 3436507 3437541 D Differs from Rv3127 by 1aa, C95F in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3436507..3437541 Mycobacterium bovis BCG str. Tokyo 172 7561290 YP_002646191.1 CDS JTY_3145 NC_012207.1 3437528 3437878 R In Mycobacterium tuberculosis strain H37Rv, Rv3128c exists as a single gene with an in-frame amber stop codon. In Mycobacterium bovis, BCG Pasteur, and BCG Tokyo, Rv3128c is split into 2, Mb3151c and Mb3152c; hypothetical protein complement(3437528..3437878) Mycobacterium bovis BCG str. Tokyo 172 7561291 YP_002646192.1 CDS JTY_3146 NC_012207.1 3437960 3438541 R In Mycobacterium tuberculosis strain H37Rv, Rv3128c exists as a single gene with an in-frame amber stop codon. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, Rv3128c is split into 2 genes. Differs from Mb3152c by 1aa, V166G in BCG Pasteur and BCG Tokyo; hypothetical protein complement(3437960..3438541) Mycobacterium bovis BCG str. Tokyo 172 7561292 YP_002646193.1 CDS JTY_3147 NC_012207.1 3439020 3439352 D hypothetical protein 3439020..3439352 Mycobacterium bovis BCG str. Tokyo 172 7561293 YP_002646194.1 CDS JTY_3148 NC_012207.1 3439335 3440726 R hypothetical protein complement(3439335..3440726) Mycobacterium bovis BCG str. Tokyo 172 7561294 YP_002646195.1 CDS JTY_3149 NC_012207.1 3440911 3441909 D hypothetical protein 3440911..3441909 Mycobacterium bovis BCG str. Tokyo 172 7561295 YP_002646196.1 CDS devS NC_012207.1 3441889 3443625 R Differs from Rv3132c by 1aa, T283I in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; two component sensor histidine kinase complement(3441889..3443625) Mycobacterium bovis BCG str. Tokyo 172 7561296 YP_002646197.1 CDS devR NC_012207.1 3443622 3444275 R probably LuxR/UhpA-family; two component transcriptional regulatory protein complement(3443622..3444275) Mycobacterium bovis BCG str. Tokyo 172 7561488 YP_002646198.1 CDS JTY_3152 NC_012207.1 3444303 3445109 R hypothetical protein complement(3444303..3445109) Mycobacterium bovis BCG str. Tokyo 172 7561487 YP_002646199.1 CDS PPE50 NC_012207.1 3445694 3446839 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a large 1337 bp insertion (I-RD08) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (381 aa versus 132 aa). Differs from Mb3159 by 1aa, K213E in BCG Pasteur. Differ from Mb3159 by 1aa, G256E in BCG Tokyo; PPE family protein 3445694..3446839 Mycobacterium bovis BCG str. Tokyo 172 7561297 YP_002646200.1 CDS PPE51 NC_012207.1 3447491 3448633 D PPE family protein 3447491..3448633 Mycobacterium bovis BCG str. Tokyo 172 7562189 YP_002646201.1 CDS JTY_3155 NC_012207.1 3449090 3449872 D Differs from Rv3137 by 1aa, L168P in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; monophosphatase 3449090..3449872 Mycobacterium bovis BCG str. Tokyo 172 7562190 YP_002646202.1 CDS pflA NC_012207.1 3449892 3450980 D Differs from Rv3138 by 2aa, N110S, P271T, and from Mb3162 by 2aa, F257S, P270L in BCG Pasteur and BCG Tokyo; pyruvate formate lyase activating protein 3449892..3450980 Mycobacterium bovis BCG str. Tokyo 172 7561298 YP_002646203.1 CDS fadE24 NC_012207.1 3451060 3452466 D acyl-CoA dehydrogenase 3451060..3452466 Mycobacterium bovis BCG str. Tokyo 172 7562397 YP_002646204.1 CDS fadE23 NC_012207.1 3452487 3453692 D acyl-CoA dehydrogenase 3452487..3453692 Mycobacterium bovis BCG str. Tokyo 172 7563373 YP_002646205.1 CDS fadB4 NC_012207.1 3453792 3454763 D NADPH quinone oxidoreductase 3453792..3454763 Mycobacterium bovis BCG str. Tokyo 172 7563372 YP_002646206.1 CDS JTY_3160 NC_012207.1 3454815 3455243 R Differs from Mb3166c by 1aa, H133Q in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3454815..3455243) Mycobacterium bovis BCG str. Tokyo 172 7562913 YP_002646207.1 CDS JTY_3161 NC_012207.1 3455351 3455752 D response regulator 3455351..3455752 Mycobacterium bovis BCG str. Tokyo 172 7561299 YP_002646208.1 CDS PPE52 NC_012207.1 3455785 3457014 R Differs from Rv3144c by 1aa, G226S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PPE family protein complement(3455785..3457014) Mycobacterium bovis BCG str. Tokyo 172 7561300 YP_002646209.1 CDS nuoA NC_012207.1 3457379 3457765 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 3457379..3457765 Mycobacterium bovis BCG str. Tokyo 172 7562191 YP_002646210.1 CDS nuoB NC_012207.1 3457774 3458328 D The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 3457774..3458328 Mycobacterium bovis BCG str. Tokyo 172 7562474 YP_002646211.1 CDS nuoC NC_012207.1 3458325 3459035 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit C 3458325..3459035 Mycobacterium bovis BCG str. Tokyo 172 7562475 YP_002646212.1 CDS nuoD NC_012207.1 3459035 3460357 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 3459035..3460357 Mycobacterium bovis BCG str. Tokyo 172 7562476 YP_002646213.1 CDS nuoE NC_012207.1 3460354 3461112 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 3460354..3461112 Mycobacterium bovis BCG str. Tokyo 172 7562477 YP_002646214.1 CDS nuoF NC_012207.1 3461109 3462446 D NADH dehydrogenase I chain F 3461109..3462446 Mycobacterium bovis BCG str. Tokyo 172 7562478 YP_002646215.1 CDS nuoG NC_012207.1 3462443 3464863 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 3462443..3464863 Mycobacterium bovis BCG str. Tokyo 172 7562479 YP_002646216.1 CDS nuoH NC_012207.1 3464979 3466211 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 3464979..3466211 Mycobacterium bovis BCG str. Tokyo 172 7562480 YP_002646217.1 CDS nuoI NC_012207.1 3466204 3466839 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 3466204..3466839 Mycobacterium bovis BCG str. Tokyo 172 7562481 YP_002646218.1 CDS nuoJ NC_012207.1 3466836 3467624 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 3466836..3467624 Mycobacterium bovis BCG str. Tokyo 172 7562482 YP_002646219.1 CDS nuoK NC_012207.1 3467621 3467920 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 3467621..3467920 Mycobacterium bovis BCG str. Tokyo 172 7562483 YP_002646220.1 CDS nuoL NC_012207.1 3467931 3469832 D Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 3467931..3469832 Mycobacterium bovis BCG str. Tokyo 172 7562484 YP_002646221.1 CDS nuoM NC_012207.1 3469829 3471490 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 3469829..3471490 Mycobacterium bovis BCG str. Tokyo 172 7562485 YP_002646222.1 CDS nuoN NC_012207.1 3471487 3473082 D Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 3471487..3473082 Mycobacterium bovis BCG str. Tokyo 172 7562486 YP_002646223.1 CDS PPE53 NC_012207.1 3473088 3474857 R In Mycobacterium bovis BCG pasteur, BCG Tokyo, and Mycobacterium bovis, albeit a 2146 bp insertion occurs overlapping the NH2-terminal part, this leads to an equivalent product, compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Rv3159c by 2aa, deletion of A64, V87A, and from Mb3183c by 1aa, V87A in BCG Pasteur and BCG Tokyo.; PPE family protein complement(3473088..3474857) Mycobacterium bovis BCG str. Tokyo 172 7562487 YP_002646224.1 CDS PPE70 NC_012207.1 3475105 3477006 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, an insertion of 2146 bp exists between PPE53 and Rv3160c compared to Mycobacterium tuberculosis strain H37Rv. This leads to an additional gene, PPE70 equivalent to MT3248 from Mycobacterium tuberculosis strain CDC1551. Differs from Mb3184c by 1aa, addition of A64 in BCG Pasteur and BCG Tokyo.; PPE family protein complement(3475105..3477006) Mycobacterium bovis BCG str. Tokyo 172 7562192 YP_002646225.1 CDS JTY_3179 NC_012207.1 3477181 3477822 R probably TetR-family; transcriptional regulatory protein complement(3477181..3477822) Mycobacterium bovis BCG str. Tokyo 172 7560801 YP_002646226.1 CDS JTY_3180 NC_012207.1 3477833 3478981 R Differs from Rv3161c by 1aa, L62V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; dioxygenase complement(3477833..3478981) Mycobacterium bovis BCG str. Tokyo 172 7561301 YP_002646227.1 CDS JTY_3181 NC_012207.1 3478897 3479487 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (T-*), leads to a longer product with different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; integral membrane protein complement(3478897..3479487) Mycobacterium bovis BCG str. Tokyo 172 7561302 YP_002646228.1 CDS JTY_3182 NC_012207.1 3479484 3480755 R Differs from Mb3188c by 1aa, D341E in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3479484..3480755) Mycobacterium bovis BCG str. Tokyo 172 7561303 YP_002646229.1 CDS moxR3 NC_012207.1 3480785 3481747 R Differs from Mb3189c by 1aa, E20G in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; methanol dehydrogenase transcriptional regulatory protein complement(3480785..3481747) Mycobacterium bovis BCG str. Tokyo 172 7561304 YP_002646230.1 CDS JTY_3184 NC_012207.1 3481755 3482237 R hypothetical protein complement(3481755..3482237) Mycobacterium bovis BCG str. Tokyo 172 7563549 YP_002646231.1 CDS JTY_3185 NC_012207.1 3482234 3483193 R Differs from Rv3166c and Mb3191c by 1aa, A202S in BCG Pasteur and BCG Tokyo; hypothetical protein complement(3482234..3483193) Mycobacterium bovis BCG str. Tokyo 172 7561305 YP_002646232.1 CDS JTY_3186 NC_012207.1 3483273 3483899 R probably TetR-family; transcriptional regulatory protein complement(3483273..3483899) Mycobacterium bovis BCG str. Tokyo 172 7561306 YP_002646233.1 CDS JTY_3187 NC_012207.1 3483944 3485080 D Differs from Mb3193 by 1aa, W65R in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3483944..3485080 Mycobacterium bovis BCG str. Tokyo 172 7561307 YP_002646234.1 CDS JTY_3188 NC_012207.1 3485080 3486204 D hypothetical protein 3485080..3486204 Mycobacterium bovis BCG str. Tokyo 172 7561308 YP_002646235.1 CDS aofH NC_012207.1 3486347 3487693 D flavin-containing monoamine oxidase 3486347..3487693 Mycobacterium bovis BCG str. Tokyo 172 7561309 YP_002646236.1 CDS hpx NC_012207.1 3487688 3488587 R Differs from Rv3171c by 1aa, M201T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; non-heme haloperoxidase complement(3487688..3488587) Mycobacterium bovis BCG str. Tokyo 172 7563979 YP_002646237.1 CDS JTY_3191 NC_012207.1 3488724 3489206 R hypothetical protein complement(3488724..3489206) Mycobacterium bovis BCG str. Tokyo 172 7563323 YP_002646238.1 CDS JTY_3192 NC_012207.1 3489285 3489887 R probably TetR/AcrR-family; transcriptional regulatory protein complement(3489285..3489887) Mycobacterium bovis BCG str. Tokyo 172 7561310 YP_002646239.1 CDS JTY_3193 NC_012207.1 3489980 3490687 D Differs from Rv3174 by 1aa, A9V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; short chain dehydrogenase 3489980..3490687 Mycobacterium bovis BCG str. Tokyo 172 7561311 YP_002646240.1 CDS JTY_3194 NC_012207.1 3490702 3492189 D catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 3490702..3492189 Mycobacterium bovis BCG str. Tokyo 172 7561312 YP_002646241.1 CDS mesTb NC_012207.1 3492186 3492503 R In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo and Mycobacterium bovis, a frameshift due to a single base deletion (C-*) splits mesT into 2 parts, mesTa and mesTb.; epoxide hydrolase complement(3492186..3492503) Mycobacterium bovis BCG str. Tokyo 172 7561313 YP_002646242.1 CDS mesTa NC_012207.1 3492515 3493141 R In Mycobacterium tuberculosis strain H37Rv, mesT exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (C-*) splits mesT into 2 parts, mesTa and mesTb; epoxide hydrolase complement(3492515..3493141) Mycobacterium bovis BCG str. Tokyo 172 7564457 YP_002646243.1 CDS JTY_3197 NC_012207.1 3493288 3494148 D non-haem peroxidase; peroxidase 3493288..3494148 Mycobacterium bovis BCG str. Tokyo 172 7564456 YP_002646244.1 CDS JTY_3198 NC_012207.1 3494279 3494638 D hypothetical protein 3494279..3494638 Mycobacterium bovis BCG str. Tokyo 172 7561314 YP_002646245.1 CDS JTY_3199 NC_012207.1 3494878 3495171 D hypothetical alanine rich protein 3494878..3495171 Mycobacterium bovis BCG str. Tokyo 172 7561315 YP_002646246.1 CDS JTY_3200 NC_012207.1 3495459 3496748 D hypothetical protein 3495459..3496748 Mycobacterium bovis BCG str. Tokyo 172 7561316 YP_002646247.1 CDS JTY_3201 NC_012207.1 3497095 3497529 R hypothetical alanine rich protein complement(3497095..3497529) Mycobacterium bovis BCG str. Tokyo 172 7561317 YP_002646248.1 CDS JTY_3202 NC_012207.1 3497532 3497984 R hypothetical protein complement(3497532..3497984) Mycobacterium bovis BCG str. Tokyo 172 7561318 YP_002646249.1 CDS JTY_3203 NC_012207.1 3498215 3498559 D hypothetical protein 3498215..3498559 Mycobacterium bovis BCG str. Tokyo 172 7561319 YP_002646250.1 CDS JTY_3204 NC_012207.1 3498556 3498885 D transcriptional regulatory protein 3498556..3498885 Mycobacterium bovis BCG str. Tokyo 172 7561320 YP_002646251.1 CDS JTY_3205 NC_012207.1 3499423 3499770 D hypothetical protein 3499423..3499770 Mycobacterium bovis BCG str. Tokyo 172 7561321 YP_002646252.1 CDS JTY_3206 NC_012207.1 3499767 3500387 D hypothetical protein 3499767..3500387 Mycobacterium bovis BCG str. Tokyo 172 7561322 YP_002646253.1 CDS JTY_3207 NC_012207.1 3500547 3501812 R Differs from Rv3190c by 2aa, P138L, A330V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3500547..3501812) Mycobacterium bovis BCG str. Tokyo 172 7561323 YP_002646254.1 CDS JTY_3208 NC_012207.1 3502436 3503470 R transposase complement(3502436..3503470) Mycobacterium bovis BCG str. Tokyo 172 7561324 YP_002646255.1 CDS JTY_3209 NC_012207.1 3504685 3505146 D hypothetical alanine and proline-rich protein 3504685..3505146 Mycobacterium bovis BCG str. Tokyo 172 7564465 YP_002646256.1 CDS JTY_3210 NC_012207.1 3505316 3508294 R Differs from Rv3193c by 2aa, E356Q, Q843R, and from Mb3215c by 1aa, E356Q in BCG Pasteur and BCG Tokyo; hypothetical protein complement(3505316..3508294) Mycobacterium bovis BCG str. Tokyo 172 7561326 YP_002646257.1 CDS JTY_3211 NC_012207.1 3508386 3509408 R hypothetical protein complement(3508386..3509408) Mycobacterium bovis BCG str. Tokyo 172 7561327 YP_002646258.1 CDS JTY_3212 NC_012207.1 3509486 3510904 D hypothetical protein 3509486..3510904 Mycobacterium bovis BCG str. Tokyo 172 7561328 YP_002646259.1 CDS JTY_3213 NC_012207.1 3510910 3511809 D hypothetical protein 3510910..3511809 Mycobacterium bovis BCG str. Tokyo 172 7561329 YP_002646260.1 CDS JTY_3214 NC_012207.1 3511818 3512018 R hypothetical protein complement(3511818..3512018) Mycobacterium bovis BCG str. Tokyo 172 7561330 YP_002646261.1 CDS JTY_3215 NC_012207.1 3512156 3513499 D ATP-binding protein ABC transporter 3512156..3513499 Mycobacterium bovis BCG str. Tokyo 172 7561331 YP_002646262.1 CDS whiB7 NC_012207.1 3513533 3513811 R transcriptional regulatory protein whiB-like complement(3513533..3513811) Mycobacterium bovis BCG str. Tokyo 172 7561332 YP_002646263.1 CDS UvrD2 NC_012207.1 3514241 3516343 R DNA helicase II homolog complement(3514241..3516343) Mycobacterium bovis BCG str. Tokyo 172 7561695 YP_002646264.1 CDS JTY_3218 NC_012207.1 3516467 3516721 D glutaredoxin protein 3516467..3516721 Mycobacterium bovis BCG str. Tokyo 172 7561676 YP_002646265.1 CDS nudC NC_012207.1 3516734 3517675 R can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase complement(3516734..3517675) Mycobacterium bovis BCG str. Tokyo 172 7561333 YP_002646266.1 CDS JTY_3220 NC_012207.1 3517734 3518801 R Differs from Rv3200c by 1aa, D12N in Mycobacterium bovis , Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane cation transporter complement(3517734..3518801) Mycobacterium bovis BCG str. Tokyo 172 7562473 YP_002646267.1 CDS JTY_3221 NC_012207.1 3518863 3522168 R ATP-dependent DNA helicase complement(3518863..3522168) Mycobacterium bovis BCG str. Tokyo 172 7561334 YP_002646268.1 CDS JTY_3222 NC_012207.1 3522165 3525332 R Differs from Rv3202c by 1aa, A748V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; ATP-dependent DNA helicase complement(3522165..3525332) Mycobacterium bovis BCG str. Tokyo 172 7561335 YP_002646269.1 CDS JTY_3223 NC_012207.1 3525409 3525627 D hypothetical protein 3525409..3525627 Mycobacterium bovis BCG str. Tokyo 172 7561336 YP_002646270.1 CDS lipV NC_012207.1 3525769 3526443 D lipase 3525769..3526443 Mycobacterium bovis BCG str. Tokyo 172 7561337 YP_002646271.1 CDS JTY_3225 NC_012207.1 3526446 3526751 D Differs from Rv3204 by 1aa, A34T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; DNA-methyltransferase 3526446..3526751 Mycobacterium bovis BCG str. Tokyo 172 7562848 YP_002646272.1 CDS JTY_3226 NC_012207.1 3526758 3527636 R hypothetical protein complement(3526758..3527636) Mycobacterium bovis BCG str. Tokyo 172 7561338 YP_002646273.1 CDS moeB1 NC_012207.1 3527663 3528841 R The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; molybdopterin biosynthesis-like protein MoeZ complement(3527663..3528841) Mycobacterium bovis BCG str. Tokyo 172 7561339 YP_002646274.1 CDS JTY_3228 NC_012207.1 3528932 3529789 R Differs from Rv3207c by 1aa, N157D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3528932..3529789) Mycobacterium bovis BCG str. Tokyo 172 7563541 YP_002646275.1 CDS JTY_3229 NC_012207.1 3530135 3530821 D probably TetR-family; transcriptional regulatory protein 3530135..3530821 Mycobacterium bovis BCG str. Tokyo 172 7561340 YP_002646276.1 CDS TB9.4 NC_012207.1 3530808 3531080 R hypothetical protein complement(3530808..3531080) Mycobacterium bovis BCG str. Tokyo 172 7561341 YP_002646277.1 CDS JTY_3231 NC_012207.1 3531405 3531965 D hypothetical threonine and proline rich protein 3531405..3531965 Mycobacterium bovis BCG str. Tokyo 172 7561837 YP_002646278.1 CDS JTY_3232 NC_012207.1 3531975 3532670 R hypothetical protein complement(3531975..3532670) Mycobacterium bovis BCG str. Tokyo 172 7561342 YP_002646279.1 CDS rhlE NC_012207.1 3532929 3534512 D Differs from Mb3237 by 1aa, V17A in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; ATP-dependent RNA helicase 3532929..3534512 Mycobacterium bovis BCG str. Tokyo 172 7561343 YP_002646280.1 CDS JTY_3234 NC_012207.1 3534525 3535748 D Differs from Mb3238 by 1aa, G225D, and from Rv3212 by 2aa, G225D, A250V in BCG Pasteur and BCG Tokyo; hypothetical alanine valine rich protein 3534525..3535748 Mycobacterium bovis BCG str. Tokyo 172 7561569 YP_002646281.1 CDS JTY_3235 NC_012207.1 3535824 3536624 R Differs from Rv3213c by 1aa, E144K in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; soj/ParA-related protein complement(3535824..3536624) Mycobacterium bovis BCG str. Tokyo 172 7561344 YP_002646282.1 CDS gpm2_1 NC_012207.1 3536778 3537389 D forms a homodimer in Mycobacterium tuberculosis; belongs to the dPGM superfamily; acid phosphatase 3536778..3537389 Mycobacterium bovis BCG str. Tokyo 172 7561345 YP_002646283.1 CDS entC_1 NC_012207.1 3537386 3538504 D isochorismate synthase 3537386..3538504 Mycobacterium bovis BCG str. Tokyo 172 7563276 YP_002646284.1 CDS JTY_3238 NC_012207.1 3538652 3538984 D acetyltransferase 3538652..3538984 Mycobacterium bovis BCG str. Tokyo 172 7562866 YP_002646285.1 CDS JTY_3239 NC_012207.1 3538936 3539367 R integral membrane protein complement(3538936..3539367) Mycobacterium bovis BCG str. Tokyo 172 7561346 YP_002646286.1 CDS JTY_3240 NC_012207.1 3539600 3540565 D hypothetical protein 3539600..3540565 Mycobacterium bovis BCG str. Tokyo 172 7561347 YP_002646287.1 CDS whiB1_1 NC_012207.1 3540845 3541099 D transcriptional regulatory protein whiB-like 3540845..3541099 Mycobacterium bovis BCG str. Tokyo 172 7561348 YP_002646288.1 CDS JTY_3242 NC_012207.1 3541161 3542666 R Differs from Rv3220c by 1aa, N47D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; two component sensor kinase complement(3541161..3542666) Mycobacterium bovis BCG str. Tokyo 172 7561689 YP_002646289.1 CDS TB7.3_1 NC_012207.1 3542683 3542898 R acetyl-CoA carboxylase biotin carboxyl carrier protein subunit complement(3542683..3542898) Mycobacterium bovis BCG str. Tokyo 172 7561349 YP_002646290.1 CDS JTY_3244 NC_012207.1 3543183 3543488 R anti-sigma factor complement(3543183..3543488) Mycobacterium bovis BCG str. Tokyo 172 7561836 YP_002646291.1 CDS JTY_3245 NC_012207.1 3543485 3544036 R hypothetical protein complement(3543485..3544036) Mycobacterium bovis BCG str. Tokyo 172 7561350 YP_002646292.1 CDS sigH_1 NC_012207.1 3544033 3544683 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE complement(3544033..3544683) Mycobacterium bovis BCG str. Tokyo 172 7561351 YP_002646293.1 CDS JTY_3247 NC_012207.1 3544983 3545831 D short chain dehydrogenase 3544983..3545831 Mycobacterium bovis BCG str. Tokyo 172 7561792 YP_002646294.1 CDS JTY_3248 NC_012207.1 3545767 3545955 D hypothetical protein 3545767..3545955 Mycobacterium bovis BCG str. Tokyo 172 7561352 YP_002646295.1 CDS JTY_3249 NC_012207.1 3545933 3546151 D hypothetical protein 3545933..3546151 Mycobacterium bovis BCG str. Tokyo 172 7561353 YP_002646296.1 CDS JTY_3250 NC_012207.1 3546148 3547572 R Differs from Rv3225c by 1aa T306A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transferase complement(3546148..3547572) Mycobacterium bovis BCG str. Tokyo 172 7561354 YP_002646297.1 CDS JTY_3251 NC_012207.1 3547696 3548454 R hypothetical protein complement(3547696..3548454) Mycobacterium bovis BCG str. Tokyo 172 7561355 YP_002646298.1 CDS aroA_1 NC_012207.1 3548509 3549861 D catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 3548509..3549861 Mycobacterium bovis BCG str. Tokyo 172 7561356 YP_002646299.1 CDS JTY_3253 NC_012207.1 3549858 3550850 D Differs from Rv3228, Mb3257 and BCG_3351 by 1aa, D169G in Mycobacterium bovis BCG Pasteur.; hypothetical protein 3549858..3550850 Mycobacterium bovis BCG str. Tokyo 172 7563996 YP_002646300.1 CDS desA3_1 NC_012207.1 3550883 3552166 R linoleoyl-CoA desaturase complement(3550883..3552166) Mycobacterium bovis BCG str. Tokyo 172 7561357 YP_002646301.1 CDS JTY_3255 NC_012207.1 3552244 3553386 R Differs from Rv3230c by 1aa, C105R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase complement(3552244..3553386) Mycobacterium bovis BCG str. Tokyo 172 7561485 YP_002646302.1 CDS JTY_3256 NC_012207.1 3553496 3554005 R In DU2 of BCG Pasteur, the second copy (BCG_3354c) is truncated.; hypothetical protein complement(3553496..3554005) Mycobacterium bovis BCG str. Tokyo 172 7561358 YP_002646303.1 CDS pvdS NC_012207.1 3554002 3554889 R transcriptional regulatory protein complement(3554002..3554889) Mycobacterium bovis BCG str. Tokyo 172 7561359 YP_002646304.1 CDS JTY_3258 NC_012207.1 3554913 3555332 R In Mycobacterium tuberculosis H37Rv, Rv3234c and Rv3233c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis (Mb3262c), a single base insertion (*-G) leads to a single product that is more similar to Rv3234c. In Mycobacterium BCG Tokyo, two bases insertion, (*-G) and (*-T) leads to two products that is more similar to Rv3234c.; hypothetical protein complement(3554913..3555332) Mycobacterium bovis BCG str. Tokyo 172 7560868 YP_002646305.1 CDS JTY_3259 NC_012207.1 3555340 3556323 R In Mycobacterium tuberculosis H37Rv, Rv3234c and Rv3233c exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-G) leads to a single product that is more similar to Rv3234c. In Mycobacterium BCG Tokyo, two bases insertion, (*-g) and (*-T) leads to two products that is more similar to Rv3234c.; hypothetical protein complement(3555340..3556323) Mycobacterium bovis BCG str. Tokyo 172 7561360 YP_002646306.1 CDS JTY_3260 NC_012207.1 3556434 3557075 D hypothetical alanine arginine proline rich protein 3556434..3557075 Mycobacterium bovis BCG str. Tokyo 172 7561361 YP_002646307.1 CDS JTY_3261 NC_012207.1 3557093 3558250 R integral membrane transport protein complement(3557093..3558250) Mycobacterium bovis BCG str. Tokyo 172 7561362 YP_002646308.1 CDS JTY_3262 NC_012207.1 3558255 3558737 R hypothetical protein complement(3558255..3558737) Mycobacterium bovis BCG str. Tokyo 172 7561363 YP_002646309.1 CDS JTY_3263 NC_012207.1 3558798 3559532 R integral membrane protein complement(3558798..3559532) Mycobacterium bovis BCG str. Tokyo 172 7561364 YP_002646310.1 CDS JTY_3264 NC_012207.1 3559591 3562737 R Differs from Mb3267c by 1aa, R867H in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane transport protein complement(3559591..3562737) Mycobacterium bovis BCG str. Tokyo 172 7561365 YP_002646311.1 CDS secA1 NC_012207.1 3562816 3565665 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(3562816..3565665) Mycobacterium bovis BCG str. Tokyo 172 7561366 YP_002646312.1 CDS JTY_3266 NC_012207.1 3565744 3566388 R hypothetical protein complement(3565744..3566388) Mycobacterium bovis BCG str. Tokyo 172 7560770 YP_002646313.1 CDS JTY_3267 NC_012207.1 3566704 3567345 R Differs from Rv3242c and Mb3270c by 1aa, S89L in Mycobacterium bovis BCG Pasteur and BCG Tokyo; hypothetical protein complement(3566704..3567345) Mycobacterium bovis BCG str. Tokyo 172 7561367 YP_002646314.1 CDS JTY_3268 NC_012207.1 3567383 3568225 R hypothetical protein complement(3567383..3568225) Mycobacterium bovis BCG str. Tokyo 172 7560876 YP_002646315.1 CDS lpqB NC_012207.1 3568293 3570044 R Differs from Rv3244c by 2aa, G142D, L394S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein LpqB complement(3568293..3570044) Mycobacterium bovis BCG str. Tokyo 172 7560877 YP_002646316.1 CDS mtrB NC_012207.1 3570044 3571747 R Differs from Rv3245c by 1aa, L517M in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; two component sensory transduction histidine kinase complement(3570044..3571747) Mycobacterium bovis BCG str. Tokyo 172 7560494 YP_002646317.1 CDS mtrA NC_012207.1 3571797 3572483 R two component sensory transduction transcriptional regulatory protein complement(3571797..3572483) Mycobacterium bovis BCG str. Tokyo 172 7563570 YP_002646318.1 CDS tmk NC_012207.1 3572553 3573197 R catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase complement(3572553..3573197) Mycobacterium bovis BCG str. Tokyo 172 7563569 YP_002646319.1 CDS sahH NC_012207.1 3573294 3574781 R catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase complement(3573294..3574781) Mycobacterium bovis BCG str. Tokyo 172 7561862 YP_002646320.1 CDS JTY_3274 NC_012207.1 3574886 3575521 R probably TetR-family; transcriptional regulatory protein complement(3574886..3575521) Mycobacterium bovis BCG str. Tokyo 172 7560754 YP_002646321.1 CDS JTY_3275 NC_012207.1 3575518 3575700 R rubredoxin RubB complement(3575518..3575700) Mycobacterium bovis BCG str. Tokyo 172 7560878 YP_002646322.1 CDS JTY_3276 NC_012207.1 3575705 3575872 R rubredoxin RubA complement(3575705..3575872) Mycobacterium bovis BCG str. Tokyo 172 7560879 YP_002646323.1 CDS alkB NC_012207.1 3575872 3577122 R transmembrane alkane 1-monooxygenase complement(3575872..3577122) Mycobacterium bovis BCG str. Tokyo 172 7560880 YP_002646324.1 CDS JTY_3278 NC_012207.1 3577231 3578718 R cationic amino acid transport integral membrane protein complement(3577231..3578718) Mycobacterium bovis BCG str. Tokyo 172 7563963 YP_002646325.1 CDS JTY_3279 NC_012207.1 3578809 3580197 D hypothetical protein 3578809..3580197 Mycobacterium bovis BCG str. Tokyo 172 7560881 YP_002646326.1 CDS manA NC_012207.1 3580175 3581401 R mannose-6-phosphate isomerase complement(3580175..3581401) Mycobacterium bovis BCG str. Tokyo 172 7560882 YP_002646327.1 CDS JTY_3281 NC_012207.1 3581409 3582449 R hypothetical protein complement(3581409..3582449) Mycobacterium bovis BCG str. Tokyo 172 7564415 YP_002646328.1 CDS manB NC_012207.1 3582446 3583843 R converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells; phosphomannomutase/phosphoglucomutase complement(3582446..3583843) Mycobacterium bovis BCG str. Tokyo 172 7560883 YP_002646329.1 CDS JTY_3283 NC_012207.1 3583945 3584436 R hypothetical protein complement(3583945..3584436) Mycobacterium bovis BCG str. Tokyo 172 7564416 YP_002646330.1 CDS JTY_3284 NC_012207.1 3584559 3584978 D hypothetical protein 3584559..3584978 Mycobacterium bovis BCG str. Tokyo 172 7560884 YP_002646331.1 CDS whiB2 NC_012207.1 3585006 3585275 R transcriptional regulatory protein WhiB-like complement(3585006..3585275) Mycobacterium bovis BCG str. Tokyo 172 7560885 YP_002646332.1 CDS fbiA NC_012207.1 3585677 3586672 D catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); LPPG:FO 2-phospho-L-lactate transferase 3585677..3586672 Mycobacterium bovis BCG str. Tokyo 172 7561690 YP_002646333.1 CDS fbiB NC_012207.1 3586669 3588015 D catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0); F420-0--gamma-glutamyl ligase 3586669..3588015 Mycobacterium bovis BCG str. Tokyo 172 7563397 YP_002646334.1 CDS JTY_3288 NC_012207.1 3588311 3589972 D DNA methylase 3588311..3589972 Mycobacterium bovis BCG str. Tokyo 172 7563398 YP_002646335.1 CDS manC NC_012207.1 3590032 3591111 R mannose-1-phosphate guanyltransferase complement(3590032..3591111) Mycobacterium bovis BCG str. Tokyo 172 7560886 YP_002646336.1 CDS wbbL1 NC_012207.1 3591113 3592006 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, an in-frame deletion of 12 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (297 aa versus 301aa); dTDP-RHA:A-D-GlcNAc-diphosphoryl polyprenol, A-3-L-rhamnosyl transferase complement(3591113..3592006) Mycobacterium bovis BCG str. Tokyo 172 7564417 YP_002646337.1 CDS rmld NC_012207.1 3592017 3592931 R Differs from Rv3266c by 1aa, P257S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; dTDP-rhamnose modification protein complement(3592017..3592931) Mycobacterium bovis BCG str. Tokyo 172 7561686 YP_002646338.1 CDS JTY_3292 NC_012207.1 3593007 3594503 D hypothetical protein 3593007..3594503 Mycobacterium bovis BCG str. Tokyo 172 7561585 YP_002646339.1 CDS JTY_3293 NC_012207.1 3594542 3595231 D hypothetical protein 3594542..3595231 Mycobacterium bovis BCG str. Tokyo 172 7560887 YP_002646340.1 CDS JTY_3294 NC_012207.1 3595356 3595637 D hypothetical protein 3595356..3595637 Mycobacterium bovis BCG str. Tokyo 172 7560888 YP_002646341.1 CDS ctpC NC_012207.1 3595648 3597804 D metal cation-transporting P-type ATPase C 3595648..3597804 Mycobacterium bovis BCG str. Tokyo 172 7560889 YP_002646342.1 CDS JTY_3296 NC_012207.1 3597801 3598469 R integral membrane protein complement(3597801..3598469) Mycobacterium bovis BCG str. Tokyo 172 7563133 YP_002646343.1 CDS JTY_3297 NC_012207.1 3598570 3599754 D Differs from Mb3300 by 1aa, R259G, and from Rv3272 by 2aa, R259G, S347N in BCG Pasteur and BCG Tokyo; hypothetical protein 3598570..3599754 Mycobacterium bovis BCG str. Tokyo 172 7560890 YP_002646344.1 CDS JTY_3298 NC_012207.1 3599759 3602053 D transmembrane carbonic anhydrase 3599759..3602053 Mycobacterium bovis BCG str. Tokyo 172 7560891 YP_002646345.1 CDS fadE25 NC_012207.1 3602042 3603211 R acyl-CoA dehydrogenase complement(3602042..3603211) Mycobacterium bovis BCG str. Tokyo 172 7560892 YP_002646346.1 CDS purE NC_012207.1 3603236 3603760 R Differs from Rv3275c by 1aa, R125G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; phosphoribosylaminoimidazole carboxylase catalytic subunit complement(3603236..3603760) Mycobacterium bovis BCG str. Tokyo 172 7563374 YP_002646347.1 CDS purK NC_012207.1 3603757 3605046 R With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit complement(3603757..3605046) Mycobacterium bovis BCG str. Tokyo 172 7560858 YP_002646348.1 CDS JTY_3302 NC_012207.1 3605000 3605818 D Differs from Rv3277 by 1 aa, L272S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 3605000..3605818 Mycobacterium bovis BCG str. Tokyo 172 7560861 YP_002646349.1 CDS JTY_3303 NC_012207.1 3605773 3606291 R Differs from Rv3278c by 1aa, K160E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur. Differs from Rv3278c by 2aa, T54I, K160E in Mycobacterium bovis BCG Tokyo.; transmembrane protein complement(3605773..3606291) Mycobacterium bovis BCG str. Tokyo 172 7560893 YP_002646350.1 CDS birA NC_012207.1 3606334 3607134 R Differs from Rv3279c by 1aa, N211D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; biotin--[acetyl-CoA-carboxylase] synthetase; biotin operon repressor complement(3606334..3607134) Mycobacterium bovis BCG str. Tokyo 172 7560894 YP_002646351.1 CDS accD5 NC_012207.1 3607184 3608830 D Differs from Rv3280 by 1aa, A448V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; propionyl-CoA carboxylase beta chain 5 3607184..3608830 Mycobacterium bovis BCG str. Tokyo 172 7562071 YP_002646352.1 CDS JTY_3306 NC_012207.1 3608811 3609281 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, an in-frame deletion of 63 bp leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (156 aa versus 177aa). Loss of tandem repeat SRVSGTNEVSDGNETNNPAPV; hypothetical protein 3608811..3609281 Mycobacterium bovis BCG str. Tokyo 172 7563925 YP_002646353.1 CDS JTY_3307 NC_012207.1 3609278 3609946 D Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 3609278..3609946 Mycobacterium bovis BCG str. Tokyo 172 7560895 YP_002646354.1 CDS sseA NC_012207.1 3609987 3610880 D Differs from Mb3311 by 1aa, G170D in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; thiosulfate sulfurtransferase 3609987..3610880 Mycobacterium bovis BCG str. Tokyo 172 7560896 YP_002646355.1 CDS JTY_3309 NC_012207.1 3610877 3611308 D hypothetical protein 3610877..3611308 Mycobacterium bovis BCG str. Tokyo 172 7561808 YP_002646356.1 CDS accA3 NC_012207.1 3611416 3613218 D biotin carboxylase, biotin carboxyl carrier protein, accA3; acetyl-/propionyl-coenzyme A carboxylase alpha chain 3611416..3613218 Mycobacterium bovis BCG str. Tokyo 172 7560897 YP_002646357.1 CDS sigF NC_012207.1 3613228 3614013 R Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is a general stress response regulator; expressed in stationary phase and under nitrogen depletion and cold shock; RNA polymerase sigma factor SigF complement(3613228..3614013) Mycobacterium bovis BCG str. Tokyo 172 7564331 YP_002646358.1 CDS rsbW NC_012207.1 3614010 3614447 R anti-sigma factor complement(3614010..3614447) Mycobacterium bovis BCG str. Tokyo 172 7561790 YP_002646359.1 CDS usfY NC_012207.1 3614645 3615058 R hypothetical protein complement(3614645..3615058) Mycobacterium bovis BCG str. Tokyo 172 7560750 YP_002646360.1 CDS JTY_3314 NC_012207.1 3615093 3615470 R transmembrane protein complement(3615093..3615470) Mycobacterium bovis BCG str. Tokyo 172 7561668 YP_002646361.1 CDS lat NC_012207.1 3615504 3616853 R catalyzes the formation of 2-aminoadipate 6-semiladehyde and glutamate from lysine and 2-oxoglutarate; L-lysine aminotransferase complement(3615504..3616853) Mycobacterium bovis BCG str. Tokyo 172 7560898 YP_002646362.1 CDS JTY_3316 NC_012207.1 3616904 3617356 R Differs from Rv3291c by 1aa, V22A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably AsnC-family; transcriptional regulatory protein complement(3616904..3617356) Mycobacterium bovis BCG str. Tokyo 172 7562810 YP_002646363.1 CDS JTY_3317 NC_012207.1 3617387 3618634 D hypothetical protein 3617387..3618634 Mycobacterium bovis BCG str. Tokyo 172 7560899 YP_002646364.1 CDS pcd NC_012207.1 3618661 3620145 D Differs from Rv3293 by 1aa, C273G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; piperideine-6-carboxilic acid dehydrogenase 3618661..3620145 Mycobacterium bovis BCG str. Tokyo 172 7560900 YP_002646365.1 CDS JTY_3319 NC_012207.1 3620245 3621054 R hypothetical protein complement(3620245..3621054) Mycobacterium bovis BCG str. Tokyo 172 7562522 YP_002646366.1 CDS JTY_3320 NC_012207.1 3621125 3621790 D probably TetR-family; transcriptional regulatory protein 3621125..3621790 Mycobacterium bovis BCG str. Tokyo 172 7560901 YP_002646367.1 CDS lhr NC_012207.1 3621834 3626375 D Differs from Rv3296 by 3aa, M719V, N818D, E1059K in Mycobacterium bovis and Mycobacterium bovis BCG Pasteur. Differs from Rv3296 by 4aa, T719V, M796L, N818D, E1059K in Mycobacterium bovis BCG Tokyo.; ATP-dependent helicase 3621834..3626375 Mycobacterium bovis BCG str. Tokyo 172 7560902 YP_002646368.1 CDS nei_1 NC_012207.1 3626379 3627146 D endonuclease VIII 3626379..3627146 Mycobacterium bovis BCG str. Tokyo 172 7562825 YP_002646369.1 CDS lpqC NC_012207.1 3627169 3628083 R esterase lipoprotein complement(3627169..3628083) Mycobacterium bovis BCG str. Tokyo 172 7562459 YP_002646370.1 CDS atsB_1 NC_012207.1 3628110 3631022 R Differs from Rv3299c by 1aa, S204G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; arylsulfatase complement(3628110..3631022) Mycobacterium bovis BCG str. Tokyo 172 7560495 YP_002646371.1 CDS JTY_3325 NC_012207.1 3631042 3631959 R Differs from Mb3328c by 1aa, D52N in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3631042..3631959) Mycobacterium bovis BCG str. Tokyo 172 7562056 YP_002646372.1 CDS phoY1_1 NC_012207.1 3631971 3632636 R Differs from Rv3301c and Mb3329c by 1aa, S74A in BCG Pasteur and BCG Tokyo; phosphate-transport system transcriptional regulatory protein PhoU homolog 1 complement(3631971..3632636) Mycobacterium bovis BCG str. Tokyo 172 7560903 YP_002646373.1 CDS glpD2_1 NC_012207.1 3632744 3634501 R glycerol-3-phosphate dehydrogenase complement(3632744..3634501) Mycobacterium bovis BCG str. Tokyo 172 7562415 YP_002646374.1 CDS lpdA_1 NC_012207.1 3634582 3635997 R catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; flavoprotein disulfide reductase complement(3634582..3635997) Mycobacterium bovis BCG str. Tokyo 172 7561938 YP_002646375.1 CDS JTY_3329 NC_012207.1 3636200 3636679 D hypothetical protein 3636200..3636679 Mycobacterium bovis BCG str. Tokyo 172 7562853 YP_002646376.1 CDS amiA1_1 NC_012207.1 3636698 3637867 R N-acyl-L-amino acid amidohydrolase complement(3636698..3637867) Mycobacterium bovis BCG str. Tokyo 172 7560904 YP_002646377.1 CDS amiB1_1 NC_012207.1 3637864 3639048 R amidase complement(3637864..3639048) Mycobacterium bovis BCG str. Tokyo 172 7563965 YP_002646378.1 CDS deoD_1 NC_012207.1 3639113 3639919 D catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 3639113..3639919 Mycobacterium bovis BCG str. Tokyo 172 7563969 YP_002646379.1 CDS pmmB_1 NC_012207.1 3639923 3641527 D Differs from Rv3308 by 1aa, G440S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; phosphomannomutase 3639923..3641527 Mycobacterium bovis BCG str. Tokyo 172 7561480 YP_002646380.1 CDS upp NC_012207.1 3641529 3642152 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(3641529..3642152) Mycobacterium bovis BCG str. Tokyo 172 7562131 YP_002646381.1 CDS sapM_1 NC_012207.1 3642257 3643156 D Differs from Rv3310 by 1aa, A171T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acid phosphatase 3642257..3643156 Mycobacterium bovis BCG str. Tokyo 172 7561659 YP_002646382.1 CDS JTY_3336 NC_012207.1 3643180 3644442 D hypothetical protein 3643180..3644442 Mycobacterium bovis BCG str. Tokyo 172 7560755 YP_002646383.1 CDS JTY_3337 NC_012207.1 3644463 3645389 R hypothetical protein complement(3644463..3645389) Mycobacterium bovis BCG str. Tokyo 172 7560905 YP_002646384.1 CDS JTY_3338 NC_012207.1 3645764 3646075 R hypothetical protein antigen complement(3645764..3646075) Mycobacterium bovis BCG str. Tokyo 172 7560906 YP_002646385.1 CDS add_1 NC_012207.1 3646146 3647243 R catalyzes the formation of inosine from adenosine; adenosine deaminase complement(3646146..3647243) Mycobacterium bovis BCG str. Tokyo 172 7560907 YP_002646386.1 CDS deoA NC_012207.1 3647243 3648526 R Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase complement(3647243..3648526) Mycobacterium bovis BCG str. Tokyo 172 7563937 YP_002646387.1 CDS cdd_1 NC_012207.1 3648523 3648924 R Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase complement(3648523..3648924) Mycobacterium bovis BCG str. Tokyo 172 7561476 YP_002646388.1 CDS sdhC_1 NC_012207.1 3649161 3649499 D cytochrome b-556 subunit; succinate dehydrogenase 3649161..3649499 Mycobacterium bovis BCG str. Tokyo 172 7562087 YP_002646389.1 CDS sdhD_1 NC_012207.1 3649496 3649930 D Differs from Rv3317 by 1aa, L54V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrophobic membrane anchor subunit; succinate dehydrogenase 3649496..3649930 Mycobacterium bovis BCG str. Tokyo 172 7560764 YP_002646390.1 CDS JTY_3345 NC_012207.1 3651746 3652663 R Differs from Mb3328c by 1aa, D52N in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3651746..3652663) Mycobacterium bovis BCG str. Tokyo 172 7562057 YP_002646391.1 CDS phoY1_2 NC_012207.1 3652675 3653340 R Differs from Rv3301c and Mb3329c by 1aa, S74A in Mycobacterium bovis BCG Pasteur and BCG Tokyo; phosphate-transport system transcriptional regulatory protein PhoU homolog 1 complement(3652675..3653340) Mycobacterium bovis BCG str. Tokyo 172 7560908 YP_002646392.1 CDS glpD2_2 NC_012207.1 3653448 3655205 R glycerol-3-phosphate dehydrogenase complement(3653448..3655205) Mycobacterium bovis BCG str. Tokyo 172 7562416 YP_002646393.1 CDS lpdA_2 NC_012207.1 3655286 3656701 R catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; flavoprotein disulfide reductase complement(3655286..3656701) Mycobacterium bovis BCG str. Tokyo 172 7561939 YP_002646394.1 CDS JTY_3349 NC_012207.1 3656904 3657383 D hypothetical protein 3656904..3657383 Mycobacterium bovis BCG str. Tokyo 172 7562854 YP_002646395.1 CDS amiA1_2 NC_012207.1 3657402 3658571 R N-acyl-L-amino acid amidohydrolase complement(3657402..3658571) Mycobacterium bovis BCG str. Tokyo 172 7560909 YP_002646396.1 CDS amiB1_2 NC_012207.1 3658568 3659752 R amidase complement(3658568..3659752) Mycobacterium bovis BCG str. Tokyo 172 7563966 YP_002646397.1 CDS deoD_2 NC_012207.1 3659817 3660623 D catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 3659817..3660623 Mycobacterium bovis BCG str. Tokyo 172 7563970 YP_002646398.1 CDS pmmB_2 NC_012207.1 3660627 3662231 D Differs from Rv3308 by 1aa, G440S in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; phosphomannomutase 3660627..3662231 Mycobacterium bovis BCG str. Tokyo 172 7561481 YP_002646399.1 CDS upp NC_012207.1 3662233 3662856 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(3662233..3662856) Mycobacterium bovis BCG str. Tokyo 172 7562132 YP_002646400.1 CDS sapM_2 NC_012207.1 3662961 3663860 D Differs from Rv3310 by 1aa, A171T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acid phosphatase 3662961..3663860 Mycobacterium bovis BCG str. Tokyo 172 7561660 YP_002646401.1 CDS JTY_3356 NC_012207.1 3663884 3665146 D hypothetical protein 3663884..3665146 Mycobacterium bovis BCG str. Tokyo 172 7560756 YP_002646402.1 CDS JTY_3357 NC_012207.1 3665167 3666093 R hypothetical protein complement(3665167..3666093) Mycobacterium bovis BCG str. Tokyo 172 7560910 YP_002646403.1 CDS JTY_3358 NC_012207.1 3666468 3666779 R hypothetical protein antigen complement(3666468..3666779) Mycobacterium bovis BCG str. Tokyo 172 7560911 YP_002646404.1 CDS add_2 NC_012207.1 3666850 3667947 R catalyzes the formation of inosine from adenosine; adenosine deaminase complement(3666850..3667947) Mycobacterium bovis BCG str. Tokyo 172 7560912 YP_002646405.1 CDS deoA NC_012207.1 3667947 3669230 R Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase complement(3667947..3669230) Mycobacterium bovis BCG str. Tokyo 172 7563938 YP_002646406.1 CDS cdd_2 NC_012207.1 3669227 3669628 R Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase complement(3669227..3669628) Mycobacterium bovis BCG str. Tokyo 172 7561477 YP_002646407.1 CDS sdhC_2 NC_012207.1 3669865 3670203 D cytochrome b-556 subunit; succinate dehydrogenase 3669865..3670203 Mycobacterium bovis BCG str. Tokyo 172 7562088 YP_002646408.1 CDS sdhD_2 NC_012207.1 3670200 3670634 D Differs from Rv3317 by 1aa, L54V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrophobic membrane anchor subunit; succinate dehydrogenase 3670200..3670634 Mycobacterium bovis BCG str. Tokyo 172 7560765 YP_002646409.1 CDS JTY_3365 NC_012207.1 3672450 3673367 R Differs from Mb3328c by 1aa, D52N in Mycobacterium tuberculosis H37Rv, BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3672450..3673367) Mycobacterium bovis BCG str. Tokyo 172 7562058 YP_002646410.1 CDS phoY1_3 NC_012207.1 3673379 3674044 R Differs from Rv3301c and Mb3329c by 1aa, S74A in BCG Pasteur and BCG Tokyo; phosphate-transport system transcriptional regulatory protein PhoU homolog 1 complement(3673379..3674044) Mycobacterium bovis BCG str. Tokyo 172 7560913 YP_002646411.1 CDS glpD2_3 NC_012207.1 3674152 3675909 R glycerol-3-phosphate dehydrogenase complement(3674152..3675909) Mycobacterium bovis BCG str. Tokyo 172 7562417 YP_002646412.1 CDS lpdA_3 NC_012207.1 3675990 3677405 R catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; flavoprotein disulfide reductase complement(3675990..3677405) Mycobacterium bovis BCG str. Tokyo 172 7561940 YP_002646413.1 CDS JTY_3369 NC_012207.1 3677608 3678087 D hypothetical protein 3677608..3678087 Mycobacterium bovis BCG str. Tokyo 172 7562855 YP_002646414.1 CDS amiA1_3 NC_012207.1 3678106 3679275 R N-acyl-L-amino acid amidohydrolase complement(3678106..3679275) Mycobacterium bovis BCG str. Tokyo 172 7560914 YP_002646415.1 CDS amiB1_3 NC_012207.1 3679272 3680456 R amidase complement(3679272..3680456) Mycobacterium bovis BCG str. Tokyo 172 7563967 YP_002646416.1 CDS deoD_3 NC_012207.1 3680521 3681327 D catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 3680521..3681327 Mycobacterium bovis BCG str. Tokyo 172 7563971 YP_002646417.1 CDS pmmB_3 NC_012207.1 3681331 3682935 D Differs from Rv3308 by 1aa, G440S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; phosphomannomutase 3681331..3682935 Mycobacterium bovis BCG str. Tokyo 172 7561482 YP_002646418.1 CDS upp NC_012207.1 3682937 3683560 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(3682937..3683560) Mycobacterium bovis BCG str. Tokyo 172 7562133 YP_002646419.1 CDS sapM_3 NC_012207.1 3683665 3684564 D Differs from Rv3310 by 1aa, A171T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acid phosphatase 3683665..3684564 Mycobacterium bovis BCG str. Tokyo 172 7561661 YP_002646420.1 CDS JTY_3376 NC_012207.1 3684588 3685850 D hypothetical protein 3684588..3685850 Mycobacterium bovis BCG str. Tokyo 172 7560757 YP_002646421.1 CDS JTY_3377 NC_012207.1 3685871 3686797 R hypothetical protein complement(3685871..3686797) Mycobacterium bovis BCG str. Tokyo 172 7560915 YP_002646422.1 CDS JTY_3378 NC_012207.1 3687172 3687483 R hypothetical protein antigen complement(3687172..3687483) Mycobacterium bovis BCG str. Tokyo 172 7560916 YP_002646423.1 CDS add_3 NC_012207.1 3687554 3688651 R catalyzes the formation of inosine from adenosine; adenosine deaminase complement(3687554..3688651) Mycobacterium bovis BCG str. Tokyo 172 7560917 YP_002646424.1 CDS deoA NC_012207.1 3688651 3689934 R Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase complement(3688651..3689934) Mycobacterium bovis BCG str. Tokyo 172 7563939 YP_002646425.1 CDS cdd_3 NC_012207.1 3689931 3690332 R Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase complement(3689931..3690332) Mycobacterium bovis BCG str. Tokyo 172 7561478 YP_002646426.1 CDS sdhC_3 NC_012207.1 3690569 3690907 D cytochrome b-556 subunit; succinate dehydrogenase 3690569..3690907 Mycobacterium bovis BCG str. Tokyo 172 7562089 YP_002646427.1 CDS sdhD_3 NC_012207.1 3690904 3691338 D Differs from Rv3317 by 1aa, L54V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hydrophobic membrane anchor subunit; succinate dehydrogenase 3690904..3691338 Mycobacterium bovis BCG str. Tokyo 172 7560766 YP_002646428.1 CDS sdhA NC_012207.1 3691618 3693240 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 3691618..3693240 Mycobacterium bovis BCG str. Tokyo 172 7560769 YP_002646429.1 CDS sdhB NC_012207.1 3693240 3694031 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 3693240..3694031 Mycobacterium bovis BCG str. Tokyo 172 7560762 YP_002646430.1 CDS JTY_3386 NC_012207.1 3694110 3694538 R hypothetical protein complement(3694110..3694538) Mycobacterium bovis BCG str. Tokyo 172 7560763 YP_002646431.1 CDS JTY_3387 NC_012207.1 3694542 3694784 R hypothetical protein complement(3694542..3694784) Mycobacterium bovis BCG str. Tokyo 172 7560918 YP_002646432.1 CDS JTY_3388 NC_012207.1 3694906 3695520 R methyltransferase complement(3694906..3695520) Mycobacterium bovis BCG str. Tokyo 172 7560919 YP_002646433.1 CDS moaX NC_012207.1 3695517 3696182 R MoaD-MoaE fusion protein complement(3695517..3696182) Mycobacterium bovis BCG str. Tokyo 172 7560920 YP_002646434.1 CDS moaC NC_012207.1 3696183 3696716 R MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC complement(3696183..3696716) Mycobacterium bovis BCG str. Tokyo 172 7563534 YP_002646435.1 CDS moaB3 NC_012207.1 3696713 3697087 R Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv; pterin-4-alpha-carbinolamine dehydratase complement(3696713..3697087) Mycobacterium bovis BCG str. Tokyo 172 7563529 YP_002646436.1 CDS moaA3 NC_012207.1 3697184 3698248 R Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv; molybdenum cofactor biosynthesis protein A complement(3697184..3698248) Mycobacterium bovis BCG str. Tokyo 172 7563527 YP_002646437.1 CDS JTY_3393 NC_012207.1 3698303 3698653 D Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv but present in CDC1551 (CDS not annotated); hypothetical protein 3698303..3698653 Mycobacterium bovis BCG str. Tokyo 172 7563524 YP_002646438.1 CDS JTY_3394 NC_012207.1 3698631 3699017 D Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv but present in CDC1551 (CDS not annotated); hypothetical protein 3698631..3699017 Mycobacterium bovis BCG str. Tokyo 172 7560921 YP_002646439.1 CDS embR2 NC_012207.1 3698893 3700038 D Belongs to the RvD5 region. Absent in Mycobacterium tuberculosis strain H37Rv; transcriptional regulatory protein 3698893..3700038 Mycobacterium bovis BCG str. Tokyo 172 7560922 YP_002646440.1 CDS JTY_3396 NC_012207.1 3700080 3700778 R Belongs to the RvD5 region. Absent from Mycobacterium tuberculosis strain H37Rv. In Mycobacterium bovis BCG Tokyo, 1b insertion leads to a shortly larger product compared with its homolog in Mycobacterium bovis (Mb3359c), Mycobacterium bovis, and BCG Pasteur (BCG_3396c) (232aa vs 214aa) and leads to product with different C-terminal part. 3Gs in BCG Tokyo, 2Gs in BCG Pasteur.; hypothetical protein complement(3700080..3700778) Mycobacterium bovis BCG str. Tokyo 172 7562861 YP_002646441.1 CDS JTY_3397 NC_012207.1 3700945 3702657 D transposase fusion protein 3700945..3702657 Mycobacterium bovis BCG str. Tokyo 172 7560923 YP_002646442.1 CDS sigJ NC_012207.1 3702590 3703528 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor SigJ complement(3702590..3703528) Mycobacterium bovis BCG str. Tokyo 172 7560924 YP_002646443.1 CDS JTY_3399 NC_012207.1 3703588 3704904 D Differs from Rv3329 by 1aa, H122Q in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3703588..3704904 Mycobacterium bovis BCG str. Tokyo 172 7561794 YP_002646444.1 CDS dacB1 NC_012207.1 3704973 3706190 D penicillin-binding protein 3704973..3706190 Mycobacterium bovis BCG str. Tokyo 172 7560925 YP_002646445.1 CDS sugI NC_012207.1 3706286 3707794 D Differs from Mycobacterium bovis (Mb3364) and Mycobacterium bovis BCG Tokyo by 5aa in-frame deletion at position 465, and from Rv3331 by same deletion and 1aa, L423P in Mycobacterium bovis BCG Pasteur.; sugar-transport integral membrane protein 3706286..3707794 Mycobacterium bovis BCG str. Tokyo 172 7561464 YP_002646446.1 CDS nagA NC_012207.1 3707791 3708942 D N-acetylglucosamine-6-phosphate deacetylase 3707791..3708942 Mycobacterium bovis BCG str. Tokyo 172 7561818 YP_002646447.1 CDS JTY_3403 NC_012207.1 3709133 3709978 R hypothetical protein complement(3709133..3709978) Mycobacterium bovis BCG str. Tokyo 172 7563591 YP_002646448.1 CDS JTY_3404 NC_012207.1 3710123 3710434 D hypothetical protein 3710123..3710434 Mycobacterium bovis BCG str. Tokyo 172 7560926 YP_002646449.1 CDS JTY_3405 NC_012207.1 3710453 3710893 D probably MerR-family; transcriptional regulatory protein 3710453..3710893 Mycobacterium bovis BCG str. Tokyo 172 7560927 YP_002646450.1 CDS JTY_3406 NC_012207.1 3710927 3711796 R Differs from Rv3335c and Mb3368c by 1aa, V86A in BCG Pasteur and BCG Tokyo.; integral membrane protein complement(3710927..3711796) Mycobacterium bovis BCG str. Tokyo 172 7560928 YP_002646451.1 CDS trpS NC_012207.1 3711817 3712827 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(3711817..3712827) Mycobacterium bovis BCG str. Tokyo 172 7560929 YP_002646452.1 CDS JTY_3408 NC_012207.1 3712852 3713745 D In Mycobacterium tuberculosis strain H37Rv, Rv3337 and Rv3338 exist as 2 genes with an overlap region between them. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base insertion (*-T) leads to a single product; hypothetical protein 3712852..3713745 Mycobacterium bovis BCG str. Tokyo 172 7561634 YP_002646453.1 CDS icd1 NC_012207.1 3713812 3715041 R Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase complement(3713812..3715041) Mycobacterium bovis BCG str. Tokyo 172 7560930 YP_002646454.1 CDS metC NC_012207.1 3715324 3716673 D catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; O-acetylhomoserine aminocarboxypropyltransferase 3715324..3716673 Mycobacterium bovis BCG str. Tokyo 172 7563339 YP_002646455.1 CDS metX NC_012207.1 3716685 3717824 D Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase 3716685..3717824 Mycobacterium bovis BCG str. Tokyo 172 7564459 YP_002646456.1 CDS JTY_3412 NC_012207.1 3717821 3718552 D methyltransferase 3717821..3718552 Mycobacterium bovis BCG str. Tokyo 172 7564467 YP_002646457.1 CDS PPE54 NC_012207.1 3718561 3722577 R In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 3555 bp in-frame deletion (RD19) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Differs from Mb3375c by 1aa, A513V and from Rv3343c by several transitions in BCG Pasteur and BCG Tokyo.; PPE family protein complement(3718561..3722577) Mycobacterium bovis BCG str. Tokyo 172 7560931 YP_002646458.1 CDS PE_PGRS50 NC_012207.1 3722626 3728256 R In Mycobacterium tuberculosis strain H37Rv, PE_PGRS50 and PE_PGRS49 exists as a single gene. In Mycobacterium bovis, a single base deletion (G-*) splits PE_PGRS50 into 2 parts, PE_PGRS50a and PE_PGRS50b and a single base deletion (C-*) leads to PE_PGRS49 and PE_PGRS50b existing as a single product. In Mycobacterium bovis BCG Pasteur and BCG Tokyo, the first deletion is absent leading to an unique single gene comprising PE_PGRS50 and PE_PGRS49; hypothetical protein complement(3722626..3728256) Mycobacterium bovis BCG str. Tokyo 172 7562193 YP_002646459.1 CDS JTY_3415 NC_012207.1 3728680 3728937 R hypothetical protein complement(3728680..3728937) Mycobacterium bovis BCG str. Tokyo 172 7562376 YP_002646460.1 CDS PPE55a NC_012207.1 3732375 3738665 R In Mycobacterium tuberculosis strain H37Rv, PPE55 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a single base deletion (G-*) splits PPE55 into 2 parts, PPE55a and PPE55b. Differs from Rv3347c by many aa substitutions and from Mb3380c by 1 aa, P1089S in BCG Pasteur and BCG Tokyo.; PPE Family protein complement(3732375..3738665) Mycobacterium bovis BCG str. Tokyo 172 7562195 YP_002646461.1 CDS JTY_3418 NC_012207.1 3739245 3739736 D transposase 3739245..3739736 Mycobacterium bovis BCG str. Tokyo 172 7562194 YP_002646462.1 CDS JTY_3419 NC_012207.1 3739773 3740513 R transposase complement(3739773..3740513) Mycobacterium bovis BCG str. Tokyo 172 7560933 YP_002646463.1 CDS PPE56a NC_012207.1 3751272 3752570 R In Mycobacterium tuberculosis strain H37Rv, PPE56 exists as a single gene. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, 2 frameshifts due to single base transversion (C-A) and a single base deletion (G-*) splits PPE56 into 3 parts, PPE56a, PPE56b and PPE56d. Differs from Rv3350c and Mb3385c by 2aa deletion at position 291 in BCG Pasteur and BCG Tokyo.; PPE Family protein complement(3751272..3752570) Mycobacterium bovis BCG str. Tokyo 172 7562197 YP_002646464.1 CDS JTY_3423 NC_012207.1 3752814 3753608 R hypothetical protein complement(3752814..3753608) Mycobacterium bovis BCG str. Tokyo 172 7562196 YP_002646465.1 CDS JTY_3424 NC_012207.1 3753690 3754061 R oxidoreductase complement(3753690..3754061) Mycobacterium bovis BCG str. Tokyo 172 7560935 YP_002646466.1 CDS JTY_3425 NC_012207.1 3754204 3754464 R hypothetical protein complement(3754204..3754464) Mycobacterium bovis BCG str. Tokyo 172 7560936 YP_002646467.1 CDS JTY_3426 NC_012207.1 3754579 3754968 D Differs from Rv3354 by 1aa, A112V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3754579..3754968 Mycobacterium bovis BCG str. Tokyo 172 7560937 YP_002646468.1 CDS JTY_3427 NC_012207.1 3754982 3755275 R hypothetical protein complement(3754982..3755275) Mycobacterium bovis BCG str. Tokyo 172 7560938 YP_002646469.1 CDS folD NC_012207.1 3755272 3756117 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(3755272..3756117) Mycobacterium bovis BCG str. Tokyo 172 7560939 YP_002646470.1 CDS JTY_3429 NC_012207.1 3756241 3756516 D hypothetical protein 3756241..3756516 Mycobacterium bovis BCG str. Tokyo 172 7563421 YP_002646471.1 CDS JTY_3430 NC_012207.1 3756513 3756770 D hypothetical protein 3756513..3756770 Mycobacterium bovis BCG str. Tokyo 172 7560940 YP_002646472.1 CDS JTY_3431 NC_012207.1 3756812 3758002 D oxidoreductase 3756812..3758002 Mycobacterium bovis BCG str. Tokyo 172 7560941 YP_002646473.1 CDS JTY_3432 NC_012207.1 3758119 3758487 D hypothetical protein 3758119..3758487 Mycobacterium bovis BCG str. Tokyo 172 7560942 YP_002646474.1 CDS JTY_3433 NC_012207.1 3758484 3759035 R hypothetical protein complement(3758484..3759035) Mycobacterium bovis BCG str. Tokyo 172 7560943 YP_002646475.1 CDS JTY_3434 NC_012207.1 3759042 3759623 R ATP/GTP-binding protein complement(3759042..3759623) Mycobacterium bovis BCG str. Tokyo 172 7560944 YP_002646476.1 CDS JTY_3435 NC_012207.1 3759604 3759972 R hypothetical protein complement(3759604..3759972) Mycobacterium bovis BCG str. Tokyo 172 7560945 YP_002646477.1 CDS JTY_3436 NC_012207.1 3759950 3760342 R Differs from Rv3364c and Mb3399c, by 1aa, L22P in BCG Pasteur and BCG Tokyo; hypothetical protein complement(3759950..3760342) Mycobacterium bovis BCG str. Tokyo 172 7560946 YP_002646478.1 CDS JTY_3437 NC_012207.1 3760339 3762969 R hypothetical protein complement(3760339..3762969) Mycobacterium bovis BCG str. Tokyo 172 7560947 YP_002646479.1 CDS spoU NC_012207.1 3763205 3763669 D tRNA/rRNA methylase 3763205..3763669 Mycobacterium bovis BCG str. Tokyo 172 7560948 YP_002646480.1 CDS PE_PGRS51 NC_012207.1 3764036 3765811 D In Mycobacterium bovis, insertions of 105 bp and of 9 bp (*-GGCAGCGGT) lead to longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (626 aa versus 588 aa). In Mycobacterium bovis BCG Pasteur and BCG Tokyo, there is no 105 bp insertion but the 9 bp insertion is presentat codon 404. Differs also from Rv3367 by 1aa, S412G in BCG Pasteur and BCG Tokyo; PE-PGRS family protein 3764036..3765811 Mycobacterium bovis BCG str. Tokyo 172 7561805 YP_002646481.1 CDS JTY_3440 NC_012207.1 3765812 3766456 R oxidoreductase complement(3765812..3766456) Mycobacterium bovis BCG str. Tokyo 172 7562377 YP_002646482.1 CDS JTY_3441 NC_012207.1 3766455 3766889 D hypothetical protein 3766455..3766889 Mycobacterium bovis BCG str. Tokyo 172 7560949 YP_002646483.1 CDS dnaE2 NC_012207.1 3766978 3770217 R DNA polymerase involved in damage-induced mutagenesis and translesion synthesis. It is not the major replicative DNA polymerase.; error-prone DNA polymerase complement(3766978..3770217) Mycobacterium bovis BCG str. Tokyo 172 7560950 YP_002646484.1 CDS JTY_3443 NC_012207.1 3770409 3771749 D Differs from Rv3371 by 2aa, G339R, V368I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3770409..3771749 Mycobacterium bovis BCG str. Tokyo 172 7561502 YP_002646485.1 CDS otsB2 NC_012207.1 3771791 3772966 D trehalose 6-phosphate phosphatase 3771791..3772966 Mycobacterium bovis BCG str. Tokyo 172 7560951 YP_002646486.1 CDS echA18 NC_012207.1 3773203 3774093 D In Mycobacterium tuberculosis H37Rv, echA18 and echA18' exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transversion (t-g) leads to a single product; enoyl-CoA hydratase 3773203..3774093 Mycobacterium bovis BCG str. Tokyo 172 7562504 YP_002646487.1 CDS amiD NC_012207.1 3774098 3775525 D amidase 3774098..3775525 Mycobacterium bovis BCG str. Tokyo 172 7561529 YP_002646488.1 CDS JTY_3447 NC_012207.1 3775633 3776286 D hypothetical protein 3775633..3776286 Mycobacterium bovis BCG str. Tokyo 172 7563974 YP_002646489.1 CDS JTY_3448 NC_012207.1 3776378 3777829 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a frameshift due to a 4 bp to 3 bp substitution (CAAT-AAC) leads to a shorter product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv; cyclase complement(3776378..3777829) Mycobacterium bovis BCG str. Tokyo 172 7560952 YP_002646490.1 CDS JTY_3449 NC_012207.1 3777834 3778724 R Differs from Rv3378c and Mb3412c by 1aa, A137V in BCG Pasteur and BCG Tokyo; hypothetical protein complement(3777834..3778724) Mycobacterium bovis BCG str. Tokyo 172 7560953 YP_002646491.1 CDS dxs2 NC_012207.1 3778733 3780343 R catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase complement(3778733..3780343) Mycobacterium bovis BCG str. Tokyo 172 7560954 YP_002646492.1 CDS lytB1 NC_012207.1 3780568 3781557 R lytB-related protein complement(3780568..3781557) Mycobacterium bovis BCG str. Tokyo 172 7561521 YP_002646493.1 CDS idsB NC_012207.1 3781557 3782609 R Differs from Rv3383c by 1aa, G132V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; polyprenyl synthetase complement(3781557..3782609) Mycobacterium bovis BCG str. Tokyo 172 7560546 YP_002646494.1 CDS JTY_3453 NC_012207.1 3783363 3783755 R hypothetical protein complement(3783363..3783755) Mycobacterium bovis BCG str. Tokyo 172 7563346 YP_002646495.1 CDS JTY_3454 NC_012207.1 3783755 3784063 R hypothetical protein complement(3783755..3784063) Mycobacterium bovis BCG str. Tokyo 172 7560955 YP_002646496.1 CDS JTY_3455 NC_012207.1 3784212 3784916 D transposase 3784212..3784916 Mycobacterium bovis BCG str. Tokyo 172 7560956 YP_002646497.1 CDS JTY_3456 NC_012207.1 3784906 3785583 D transposase 3784906..3785583 Mycobacterium bovis BCG str. Tokyo 172 7560957 YP_002646498.1 CDS PE_PGRS52 NC_012207.1 3785773 3788025 D In Mycobacterium bovis and Mycobacterium bovis BCG Pasteur and BCG Tokyo, insertions of 60 bp and 78 bp, and deletions of 75 bp and 9 bp (CGGCGGCGC-*), lead to a longer product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (750 aa and 749 aa versus 731 aa). Differs from Mb3420 by 1aa insertion, A205 in BCG Pasteur and BCG Tokyo; PE-PGRS family protein 3785773..3788025 Mycobacterium bovis BCG str. Tokyo 172 7564004 YP_002646499.1 CDS JTY_3458 NC_012207.1 3788096 3788968 R Differs from Mb3421c by 1aa, P172L in Mycobacteirum tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; dehydrogenase complement(3788096..3788968) Mycobacterium bovis BCG str. Tokyo 172 7562378 YP_002646500.1 CDS lpqD NC_012207.1 3789042 3789752 D lipoprotein 3789042..3789752 Mycobacterium bovis BCG str. Tokyo 172 7564005 YP_002646501.1 CDS acrA1 NC_012207.1 3789798 3791750 D short chain dehydrogenase 3789798..3791750 Mycobacterium bovis BCG str. Tokyo 172 7560496 YP_002646502.1 CDS cmaA1 NC_012207.1 3791751 3792614 R Differs from Rv3392c by 1aa, S112N in Mycobacteirum bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; cyclopropane-fatty-acyl-phospholipid synthase 1 complement(3791751..3792614) Mycobacterium bovis BCG str. Tokyo 172 7563934 YP_002646503.1 CDS iunH NC_012207.1 3792638 3793564 D nucleoside hydrolase 3792638..3793564 Mycobacterium bovis BCG str. Tokyo 172 7562114 YP_002646504.1 CDS JTY_3463 NC_012207.1 3793619 3795202 R hypothetical protein complement(3793619..3795202) Mycobacterium bovis BCG str. Tokyo 172 7562797 YP_002646505.1 CDS JTY_3464 NC_012207.1 3795199 3795813 R Differs from Rv3395c by 2aa, V3A, M104V in Mycobacteirum bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3795199..3795813) Mycobacterium bovis BCG str. Tokyo 172 7564006 YP_002646506.1 CDS JTY_3465 NC_012207.1 3795896 3796522 D hypothetical protein 3795896..3796522 Mycobacterium bovis BCG str. Tokyo 172 7564007 YP_002646507.1 CDS guaA NC_012207.1 3796678 3798255 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(3796678..3798255) Mycobacterium bovis BCG str. Tokyo 172 7564008 YP_002646508.1 CDS phyA NC_012207.1 3798267 3799175 R phytoene synthase complement(3798267..3799175) Mycobacterium bovis BCG str. Tokyo 172 7563287 YP_002646509.1 CDS idsA1 NC_012207.1 3799204 3800283 R multifunctional geranylgeranyl pyrophosphate synthetase complement(3799204..3800283) Mycobacterium bovis BCG str. Tokyo 172 7562420 YP_002646510.1 CDS JTY_3469 NC_012207.1 3800306 3801352 D Differs from Rv3399 by 1aa, E330A in Mycobacterium tuberculosis CDC1551, Mycobacteirum bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3800306..3801352 Mycobacterium bovis BCG str. Tokyo 172 7563344 YP_002646511.1 CDS JTY_3470 NC_012207.1 3801416 3802204 D hydrolase 3801416..3802204 Mycobacterium bovis BCG str. Tokyo 172 7564009 YP_002646512.1 CDS JTY_3471 NC_012207.1 3802219 3804579 D Differs from Mb3434 by 1aa, R658H in Mycobacterium bovis BCG Pasteur and by 2aa, R658H, R750L in Mycobacterium bovis BCG Tokyo.; hypothetical protein 3802219..3804579 Mycobacterium bovis BCG str. Tokyo 172 7564010 YP_002646513.1 CDS JTY_3472 NC_012207.1 3805195 3806247 R In Mycobacterium bovis BCG Pasteur and BCG Tokyo, and Mycobacterium bovis, a single base transversion (c-g) leads to a shorter product. Differs from Mb3436c by 1aa, R154C in BCG Pasteur and BCG Tokyo; hypothetical protein complement(3805195..3806247) Mycobacterium bovis BCG str. Tokyo 172 7564011 YP_002646514.1 CDS JTY_3473 NC_012207.1 3806618 3808219 R hypothetical protein complement(3806618..3808219) Mycobacterium bovis BCG str. Tokyo 172 7564012 YP_002646515.1 CDS JTY_3474 NC_012207.1 3808236 3808940 R hypothetical protein complement(3808236..3808940) Mycobacterium bovis BCG str. Tokyo 172 7564013 YP_002646516.1 CDS JTY_3476 NC_012207.1 3809664 3810551 D dioxygenase 3809664..3810551 Mycobacterium bovis BCG str. Tokyo 172 7564015 YP_002646517.1 CDS JTY_3477 NC_012207.1 3810586 3810885 D hypothetical protein 3810586..3810885 Mycobacterium bovis BCG str. Tokyo 172 7564016 YP_002646518.1 CDS JTY_3478 NC_012207.1 3810882 3811292 D Differs from Rv3408 by 1aa, L46S in Mycobacteirum bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3810882..3811292 Mycobacterium bovis BCG str. Tokyo 172 7564017 YP_002646519.1 CDS choD NC_012207.1 3811325 3813061 R cholesterol oxidase precursor complement(3811325..3813061) Mycobacterium bovis BCG str. Tokyo 172 7564018 YP_002646520.1 CDS guaB3 NC_012207.1 3813117 3814244 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase complement(3813117..3814244) Mycobacterium bovis BCG str. Tokyo 172 7562103 YP_002646521.1 CDS guaB2 NC_012207.1 3814264 3815853 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(3814264..3815853) Mycobacterium bovis BCG str. Tokyo 172 7563290 YP_002646522.1 CDS JTY_3482 NC_012207.1 3816060 3816470 D hypothetical protein 3816060..3816470 Mycobacterium bovis BCG str. Tokyo 172 7563289 YP_002646523.1 CDS JTY_3483 NC_012207.1 3816480 3817379 R hypothetical alanine and proline rich protein complement(3816480..3817379) Mycobacterium bovis BCG str. Tokyo 172 7564019 YP_002646524.1 CDS sigD NC_012207.1 3817372 3818010 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase; RNA polymerase sigma factor SigD complement(3817372..3818010) Mycobacterium bovis BCG str. Tokyo 172 7564020 YP_002646525.1 CDS JTY_3485 NC_012207.1 3818028 3818855 R hypothetical protein complement(3818028..3818855) Mycobacterium bovis BCG str. Tokyo 172 7560792 YP_002646526.1 CDS whiB3 NC_012207.1 3819226 3819534 D transcriptional regulatory protein whiB-like 3819226..3819534 Mycobacterium bovis BCG str. Tokyo 172 7564021 YP_002646527.1 CDS groEL NC_012207.1 3819606 3821225 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth; molecular chaperone GroEL complement(3819606..3821225) Mycobacterium bovis BCG str. Tokyo 172 7561691 YP_002646528.1 CDS groES NC_012207.1 3821320 3821622 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(3821320..3821622) Mycobacterium bovis BCG str. Tokyo 172 7563283 YP_002646529.1 CDS gcp NC_012207.1 3821889 3822923 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease complement(3821889..3822923) Mycobacterium bovis BCG str. Tokyo 172 7563284 YP_002646530.1 CDS rimI NC_012207.1 3822920 3823396 R ribosomal-protein-alanine acetyltransferase complement(3822920..3823396) Mycobacterium bovis BCG str. Tokyo 172 7561907 YP_002646531.1 CDS JTY_3491 NC_012207.1 3823393 3824028 R hypothetical protein complement(3823393..3824028) Mycobacterium bovis BCG str. Tokyo 172 7561578 YP_002646532.1 CDS JTY_3492 NC_012207.1 3824025 3824531 R hypothetical protein complement(3824025..3824531) Mycobacterium bovis BCG str. Tokyo 172 7564022 YP_002646533.1 CDS alr NC_012207.1 3824528 3825754 R converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase complement(3824528..3825754) Mycobacterium bovis BCG str. Tokyo 172 7564023 YP_002646534.1 CDS JTY_3494 NC_012207.1 3826048 3826410 R hypothetical protein complement(3826048..3826410) Mycobacterium bovis BCG str. Tokyo 172 7563964 YP_002646535.1 CDS PPE57 NC_012207.1 3826573 3827109 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a large deletion of 4926 bp (RD6) leads to the loss of the COOH part of PPE57, and the following CDSs, PPE58, Rv3427c, Rv3428c and the NH2-part of PPE59 compared to Mycobacterium tuberculosis strain H37Rv; PPE family protein 3826573..3827109 Mycobacterium bovis BCG str. Tokyo 172 7564024 YP_002646536.1 CDS JTY_3496 NC_012207.1 3827050 3828213 R Differs from Mb3460c by 1aa, R233H in Mycobacteirum tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transposase complement(3827050..3828213) Mycobacterium bovis BCG str. Tokyo 172 7562199 YP_002646537.1 CDS JTY_3497 NC_012207.1 3828702 3829547 R transposase complement(3828702..3829547) Mycobacterium bovis BCG str. Tokyo 172 7564025 YP_002646538.1 CDS gadB NC_012207.1 3829780 3831162 R glutamate decarboxylase complement(3829780..3831162) Mycobacterium bovis BCG str. Tokyo 172 7564026 YP_002646539.1 CDS JTY_3499 NC_012207.1 3831200 3832621 R Differs from Mb3463c by 1aa, A436 deleted, and from Rv3433c by 2aa, A436 deleted, A442S in Mycobacterium bovis BCG Pasteur. Differs from Rv3433c by 1aa, A442S in Mycobacterium bovis BCG Tokyo.; hypothetical protein complement(3831200..3832621) Mycobacterium bovis BCG str. Tokyo 172 7561895 YP_002646540.1 CDS JTY_3500 NC_012207.1 3832623 3833336 R Differs from Mb3464c by 1aa, A193T in Mycobacteirum tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein complement(3832623..3833336) Mycobacterium bovis BCG str. Tokyo 172 7564027 YP_002646541.1 CDS JTY_3501 NC_012207.1 3833347 3834201 R transmembrane protein complement(3833347..3834201) Mycobacterium bovis BCG str. Tokyo 172 7564028 YP_002646542.1 CDS glmS NC_012207.1 3834423 3836297 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(3834423..3836297) Mycobacterium bovis BCG str. Tokyo 172 7564029 YP_002646543.1 CDS JTY_3503 NC_012207.1 3836319 3836795 D Differs from Rv3437 by 1aa P84L in Mycobacteirum bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 3836319..3836795 Mycobacterium bovis BCG str. Tokyo 172 7561924 YP_002646544.1 CDS JTY_3504 NC_012207.1 3836805 3837647 D hypothetical protein 3836805..3837647 Mycobacterium bovis BCG str. Tokyo 172 7564030 YP_002646545.1 CDS JTY_3505 NC_012207.1 3837667 3839070 R hypothetical alanine and proline rich protein complement(3837667..3839070) Mycobacterium bovis BCG str. Tokyo 172 7564031 YP_002646546.1 CDS JTY_3506 NC_012207.1 3839073 3839384 R hypothetical protein complement(3839073..3839384) Mycobacterium bovis BCG str. Tokyo 172 7564032 YP_002646547.1 CDS glmM NC_012207.1 3839432 3840778 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(3839432..3840778) Mycobacterium bovis BCG str. Tokyo 172 7564033 YP_002646548.1 CDS rpsI NC_012207.1 3840903 3841358 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(3840903..3841358) Mycobacterium bovis BCG str. Tokyo 172 7563562 YP_002646549.1 CDS rplM NC_012207.1 3841355 3841798 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(3841355..3841798) Mycobacterium bovis BCG str. Tokyo 172 7560736 YP_002646550.1 CDS esxT NC_012207.1 3842031 3842333 R hypothetical protein complement(3842031..3842333) Mycobacterium bovis BCG str. Tokyo 172 7561613 YP_002646551.1 CDS esxU NC_012207.1 3842354 3842731 R hypothetical protein complement(3842354..3842731) Mycobacterium bovis BCG str. Tokyo 172 7562890 YP_002646552.1 CDS JTY_3512 NC_012207.1 3842724 3843938 R hypothetical alanine and valine rich protein complement(3842724..3843938) Mycobacterium bovis BCG str. Tokyo 172 7562891 YP_002646553.1 CDS JTY_3513 NC_012207.1 3843935 3847645 R Differs from Rv3444c by 1 aa, G1082S and Mb3477c by 1 aa G1159S in BCG Pasteur and BCG Tokyo; hypothetical protein complement(3843935..3847645) Mycobacterium bovis BCG str. Tokyo 172 7564034 YP_002646554.1 CDS JTY_3514 NC_012207.1 3847759 3849162 D Differs from Mb3478 by 1aa A265D in Mycobacteirum tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein 3847759..3849162 Mycobacterium bovis BCG str. Tokyo 172 7564035 YP_002646555.1 CDS JTY_3515 NC_012207.1 3849159 3850526 D serine protease 3849159..3850526 Mycobacterium bovis BCG str. Tokyo 172 7564036 YP_002646556.1 CDS JTY_3516 NC_012207.1 3850491 3851903 R hypothetical protein complement(3850491..3851903) Mycobacterium bovis BCG str. Tokyo 172 7564037 YP_002646557.1 CDS cut3 NC_012207.1 3852024 3852812 D Differs from Rv3451 and Mb3481 by deletion of 1aa,262R in BCG Pasteur and BCG Tokyo; cutinase precursor 3852024..3852812 Mycobacterium bovis BCG str. Tokyo 172 7564038 YP_002646558.1 CDS cut4 NC_012207.1 3852859 3853539 D cutinase precursor 3852859..3853539 Mycobacterium bovis BCG str. Tokyo 172 7563144 YP_002646559.1 CDS JTY_3519 NC_012207.1 3853811 3855496 D In Mycobacterium tuberculosis H37Rv, Rv3453 and Rv3454 exist as 2 genes. In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base deletion (T-*) results in a single product that is more similar to Rv3454. Differs from Mb3483 by 1aa, V328I in BCG Pasteur and BCG Tokyo; transmembrane protein 3853811..3855496 Mycobacterium bovis BCG str. Tokyo 172 7563145 YP_002646560.1 CDS truA NC_012207.1 3855458 3856228 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(3855458..3856228) Mycobacterium bovis BCG str. Tokyo 172 7564039 YP_002646561.1 CDS rplQ NC_012207.1 3856296 3856838 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(3856296..3856838) Mycobacterium bovis BCG str. Tokyo 172 7561636 YP_002646562.1 CDS rpoA NC_012207.1 3856870 3857913 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(3856870..3857913) Mycobacterium bovis BCG str. Tokyo 172 7561617 YP_002646563.1 CDS rpsD NC_012207.1 3858064 3858669 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(3858064..3858669) Mycobacterium bovis BCG str. Tokyo 172 7560724 YP_002646564.1 CDS rpsK NC_012207.1 3858678 3859097 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(3858678..3859097) Mycobacterium bovis BCG str. Tokyo 172 7560731 YP_002646565.1 CDS rpsM NC_012207.1 3859101 3859475 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(3859101..3859475) Mycobacterium bovis BCG str. Tokyo 172 7560738 YP_002646566.1 CDS rpmJ NC_012207.1 3859691 3859804 R smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 complement(3859691..3859804) Mycobacterium bovis BCG str. Tokyo 172 7560740 YP_002646567.1 CDS infA NC_012207.1 3859837 3860058 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(3859837..3860058) Mycobacterium bovis BCG str. Tokyo 172 7560723 YP_002646568.1 CDS JTY_3528 NC_012207.1 3860312 3861169 D hypothetical protein 3860312..3861169 Mycobacterium bovis BCG str. Tokyo 172 7562785 YP_002646569.1 CDS rmlB1 NC_012207.1 3861242 3862237 D dTDP-glucose 4,6-dehydratase 3861242..3862237 Mycobacterium bovis BCG str. Tokyo 172 7564040 YP_002646570.1 CDS rmlC NC_012207.1 3862239 3862847 D dTDP-4-dehydrorhamnose 3,5-epimerase 3862239..3862847 Mycobacterium bovis BCG str. Tokyo 172 7561582 YP_002646571.1 CDS JTY_3531 NC_012207.1 3862930 3863598 D Differs from Rv3466 by 4aa, T56A, T63A, L91R, I131V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3862930..3863598 Mycobacterium bovis BCG str. Tokyo 172 7561584 YP_002646572.1 CDS JTY_3532 NC_012207.1 3863369 3864322 D Differs from Rv3467 by 6aa, E134K, G245A, D262G, R275H, K276N, E315K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3863369..3864322 Mycobacterium bovis BCG str. Tokyo 172 7564041 YP_002646573.1 CDS rmlB2 NC_012207.1 3864380 3865474 R Differs from Rv3468c by 1aa, V62I in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; dTDP-glucose 4,6-dehydratase complement(3864380..3865474) Mycobacterium bovis BCG str. Tokyo 172 7564042 YP_002646574.1 CDS mhpE NC_012207.1 3865478 3866488 R catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase complement(3865478..3866488) Mycobacterium bovis BCG str. Tokyo 172 7561583 YP_002646575.1 CDS ilvB2 NC_012207.1 3866549 3868207 R Differs from Mb3499c by 1aa, G421E in Mycobacterium tuberculosis H37Rv, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acetolactate synthase large subunit complement(3866549..3868207) Mycobacterium bovis BCG str. Tokyo 172 7564472 YP_002646576.1 CDS JTY_3536 NC_012207.1 3868213 3868746 R Differs from Mb3500c by 1aa, C155W in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3868213..3868746) Mycobacterium bovis BCG str. Tokyo 172 7562777 YP_002646577.1 CDS JTY_3537 NC_012207.1 3868767 3869273 D hypothetical protein 3868767..3869273 Mycobacterium bovis BCG str. Tokyo 172 7564043 YP_002646578.1 CDS bpoA NC_012207.1 3869353 3870138 R peroxidase complement(3869353..3870138) Mycobacterium bovis BCG str. Tokyo 172 7564044 YP_002646579.1 CDS kgtP NC_012207.1 3870418 3871767 R Differs from Rv3476c by 2aa, F81L, V144A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; dicarboxylic acid transport integral membrane protein complement(3870418..3871767) Mycobacterium bovis BCG str. Tokyo 172 7562076 YP_002646580.1 CDS PE31 NC_012207.1 3872140 3872436 D Differs from Rv3477 by 1aa, A26V in Mycobacterium tuberculosis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; PE family protein 3872140..3872436 Mycobacterium bovis BCG str. Tokyo 172 7562808 YP_002646581.1 CDS PPE60 NC_012207.1 3872473 3873654 D PE family protein 3872473..3873654 Mycobacterium bovis BCG str. Tokyo 172 7561731 YP_002646582.1 CDS JTY_3542 NC_012207.1 3873867 3875168 D In Mycobacterium tuberculosis strain H37Rv, Rv3479 exists as a single gene. In Mycobacterium bovis BCG Pasteur, and BCG Tokyo, and Mycobacterium bovis, a 713 bp deletion (RD18) splits Rv3479 into 2 parts, Mb3507 and Mb3508. Differs from Rv3479 by 1aa, R174L in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 3873867..3875168 Mycobacterium bovis BCG str. Tokyo 172 7560794 YP_002646583.1 CDS JTY_3543 NC_012207.1 3875173 3876219 D In Mycobacterium tuberculosis strain H37Rv, Rv3479 exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a 713 bp deletion (RD18) splits Rv3479 into 2 parts, Mb3507 and Mb3508. Differs from Rv3479 by 1aa, N344T in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 3875173..3876219 Mycobacterium bovis BCG str. Tokyo 172 7564045 YP_002646584.1 CDS JTY_3544 NC_012207.1 3876243 3877736 R In Mycobacterium tuberculosis strain H37Rv (Rv3480c), BCG Pasteur and BCG Tokyo, exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (GT-*) splits Rv3480c into 2 parts, Mb3509c and Mb3510c. Differs from Rv3480c and Mb3510c by 1aa, N205D; hypothetical protein complement(3876243..3877736) Mycobacterium bovis BCG str. Tokyo 172 7564046 YP_002646585.1 CDS JTY_3545 NC_012207.1 3877827 3878516 R integral membrane protein complement(3877827..3878516) Mycobacterium bovis BCG str. Tokyo 172 7564047 YP_002646586.1 CDS JTY_3546 NC_012207.1 3877951 3879441 R In Mycobacterium bovis BCG Pasteur (BCG_3546c) and BCG Tokyo, a single base insertion (C) at position equivalent to Mycobacterium tuberculosis H37Rv position 3901442-3901443 leads to frameshift and longer product of 496 aa compared to Rv3482c, len: 260 aa; hypothetical protein complement(3877951..3879441) Mycobacterium bovis BCG str. Tokyo 172 7564048 YP_002646587.1 CDS JTY_3547 NC_012207.1 3879485 3880147 R hypothetical protein complement(3879485..3880147) Mycobacterium bovis BCG str. Tokyo 172 7564049 YP_002646588.1 CDS cpsA NC_012207.1 3880413 3881951 D hypothetical protein 3880413..3881951 Mycobacterium bovis BCG str. Tokyo 172 7564050 YP_002646589.1 CDS JTY_3549 NC_012207.1 3881957 3882901 R short chain dehydrogenase complement(3881957..3882901) Mycobacterium bovis BCG str. Tokyo 172 7563121 YP_002646590.1 CDS JTY_3550 NC_012207.1 3883107 3883556 D hypothetical protein 3883107..3883556 Mycobacterium bovis BCG str. Tokyo 172 7564051 YP_002646591.1 CDS lipF NC_012207.1 3883509 3884342 R esterase/lipase complement(3883509..3884342) Mycobacterium bovis BCG str. Tokyo 172 7564052 YP_002646592.1 CDS JTY_3552 NC_012207.1 3885002 3885325 D Differs from Rv3488 by 1aa, R98G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; hypothetical protein 3885002..3885325 Mycobacterium bovis BCG str. Tokyo 172 7562834 YP_002646593.1 CDS JTY_3553 NC_012207.1 3885407 3885571 D hypothetical protein 3885407..3885571 Mycobacterium bovis BCG str. Tokyo 172 7564053 YP_002646594.1 CDS otsA NC_012207.1 3885571 3887073 D Differs from Rv3490 by 1aa, L334V in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo.; UDP-forming; alpha,alpha-trehalose-phosphate synthase 3885571..3887073 Mycobacterium bovis BCG str. Tokyo 172 7564054 YP_002646595.1 CDS JTY_3555 NC_012207.1 3887225 3887803 D hypothetical protein 3887225..3887803 Mycobacterium bovis BCG str. Tokyo 172 7562502 YP_002646596.1 CDS JTY_3556 NC_012207.1 3887800 3888282 R hypothetical protein complement(3887800..3888282) Mycobacterium bovis BCG str. Tokyo 172 7564055 YP_002646597.1 CDS JTY_3557 NC_012207.1 3888282 3889010 R hypothetical protein complement(3888282..3889010) Mycobacterium bovis BCG str. Tokyo 172 7564056 YP_002646598.1 CDS mce4F NC_012207.1 3889010 3890704 R Differs from Rv3494c by 1aa, G245D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; MCE-family protein complement(3889010..3890704) Mycobacterium bovis BCG str. Tokyo 172 7564057 YP_002646599.1 CDS lprN NC_012207.1 3890715 3891869 R MCE-family lipoprotein complement(3890715..3891869) Mycobacterium bovis BCG str. Tokyo 172 7564446 YP_002646600.1 CDS mce4D NC_012207.1 3891866 3893221 R MCE-family protein complement(3891866..3893221) Mycobacterium bovis BCG str. Tokyo 172 7560531 YP_002646601.1 CDS mce4C NC_012207.1 3893218 3894291 R Differs from Mb3527c and Rv3497c by 1aa, P46T in BCG Pasteur and BCG Tokyo.; MCE-family protein complement(3893218..3894291) Mycobacterium bovis BCG str. Tokyo 172 7564445 YP_002646602.1 CDS mce4B NC_012207.1 3894281 3895333 R MCE-family protein complement(3894281..3895333) Mycobacterium bovis BCG str. Tokyo 172 7564444 YP_002646603.1 CDS mce4A NC_012207.1 3895333 3896535 R MCE-family protein complement(3895333..3896535) Mycobacterium bovis BCG str. Tokyo 172 7564443 YP_002646604.1 CDS yrbE4B NC_012207.1 3896555 3897397 R hypothetical protein complement(3896555..3897397) Mycobacterium bovis BCG str. Tokyo 172 7564442 YP_002646605.1 CDS yrbE4A NC_012207.1 3897432 3898196 R hypothetical protein complement(3897432..3898196) Mycobacterium bovis BCG str. Tokyo 172 7561456 YP_002646606.1 CDS fabG NC_012207.1 3898422 3899375 R Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(3898422..3899375) Mycobacterium bovis BCG str. Tokyo 172 7561455 YP_002646607.1 CDS fdxD NC_012207.1 3899400 3899591 R ferredoxin complement(3899400..3899591) Mycobacterium bovis BCG str. Tokyo 172 7562899 YP_002646608.1 CDS fadE26 NC_012207.1 3899806 3901008 D acyl-CoA dehydrogenase 3899806..3901008 Mycobacterium bovis BCG str. Tokyo 172 7563409 YP_002646609.1 CDS fadE27 NC_012207.1 3901033 3902154 D Differs from Rv3505 by 1aa V218A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo.; acyl-CoA dehydrogenase 3901033..3902154 Mycobacterium bovis BCG str. Tokyo 172 7563375 YP_002646610.1 CDS fadD17 NC_012207.1 3902225 3903733 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 3902225..3903733 Mycobacterium bovis BCG str. Tokyo 172 7563376 YP_002646611.1 CDS PE_PGRS53 NC_012207.1 3903904 3908022 D In Mycobacterium bovis, insertions of 18 bp, 72 bp and 9 bp (*-CGGCGGCAC), and deletions of 90 bp, 54 bp and 18 bp, and Mycobacterium bovis BCG Pasteur and BCG Tokyo, insertions of 18 bp, 81 bp and 9 bp (*-CGGCGGCAC), and deletions of 90 bp, 27 bp and 18 bp, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (1360 aa and 1372 aa versus 1381 aa). Differs from Mb3537 by 2 insertions of 9aa and 3aa and by 1aa, N599D. Differs from Rv3507 by several insertions, deletions and by 2aa, N599D, G742D in BCG Pasteur. Differs from Mb3537 by 2 insertions of 9aa and 3aa in BCG Tokyo. Differs form Rv3507 by several insertions, deletions and by 1aa, G742D in BCG Tokyo.; PE-PGRS family protein 3903904..3908022 Mycobacterium bovis BCG str. Tokyo 172 7562923 YP_002646612.1 CDS PE_PGRS54 NC_012207.1 3908313 3914465 D In Mycobacterium bovis BCG Pasteur and BCG Tokyo, several insertions lead to a longer product compared to its homolog in Mycobacterium bovis (2094 aa in BCG Pasteur and 2055 aa in BCG Tokyo versus 1460 aa). The PE_PGRS54 gene of BCG Tokyo (6153bp) is 132bp shorter than that of BCG Pasteur (6285bp). There are two repeats of 465bp in BCG Tokyo and one such repeat in BCG Pasteur, as well as three repeats of 552bp in BCG Tokyo and four repeats in BCG Pasteur.; PE-PGRS family protein 3908313..3914465 Mycobacterium bovis BCG str. Tokyo 172 7562379 YP_002646613.1 CDS ilvX NC_012207.1 3914632 3916179 R thiamine-pyrophosphate requiring enzyme; hypothetical protein complement(3914632..3916179) Mycobacterium bovis BCG str. Tokyo 172 7562380 YP_002646614.1 CDS JTY_3574 NC_012207.1 3916176 3917012 R hypothetical protein complement(3916176..3917012) Mycobacterium bovis BCG str. Tokyo 172 7562783 YP_002646615.1 CDS PE_PGRS55 NC_012207.1 3917372 3922459 D In Mycobacterium tuberculosis H37Rv, PE_PGRS55 and PE_PGRS56 exist as 2 genes. In Mycobacterium bovis, a 344bp insertion results in a single product which is more similar to PE_PGRS55. In Mycobacterium bovis BCG Pasteur and BCG Tokyo two deletions of 138bp and 246bp lead to a shorter product in BCG Pasteur compared to its homolog Mycobacterium bovis (1810 aa versus 1938 aa). Also differs from Mb3541 by 3aa, D628A, D743A and D857A. In BCG Tokyo, the PE_PGRS55 gene (5088bp, 1695aa) is 345bp shorter than that of BCG Pasteur (5433bp). As 345bp is the length of a repeat in the gene, the difference reflected the copy number of both BCG strains.; PE-PGRS family protein 3917372..3922459 Mycobacterium bovis BCG str. Tokyo 172 7564058 YP_002646616.1 CDS fadD18 NC_012207.1 3922588 3923244 R fatty-acid-CoA ligase complement(3922588..3923244) Mycobacterium bovis BCG str. Tokyo 172 7562381 YP_002646617.1 CDS PE_PGRS57 NC_012207.1 3923290 3925359 D In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a deletion of 111 bp and an insertion of 360 bp (361bp in BCG Tokyo) lead to a longer product compared to its homolog Mycobacterium bovis (2094aa versus 1460aa). Also differs from Mb3543 by 2aa, S80L and T93A in BCG Pasteur. In BCG Tokyo, a deletion of 117 bp and an insertion of 345 bp, 2bp, and T, A, insertions after 1958:G, 1970:C of BCG Pasteur (BCG_3577), and 1bp, G, deletion at 1963:G of BCG Pasteur (BCG_3577), lead to two products, 689aa and 284aa. Also differs from Mb3543 by 2aa, S80L and T93A in BCG Tokyo.; PE-PGRS family protein 3923290..3925359 Mycobacterium bovis BCG str. Tokyo 172 7562924 YP_002646618.1 CDS PE_PGRS57 NC_012207.1 3925664 3926518 D In Mycobacterium bovis BCG Pasteur a deletion of 111 bp and an insertion of 360 bp lead to a longer product compared to its homolog Mycobacterium bovis (2094aa versus 1460aa). Also differs from Mb3543 by 2aa, S80L and T93A. In BCG Tokyo, 2bp, T, A, insertions after 1958:G and 1970:C of BCG Pasteur (BCG_3577), 1bp, G, deletion at 1963:G of BCG_3577. The PE_PGRS57 of BCG Tokyo divided into 2 parts, 689aa and 284aa.; PE-PGRS family protein 3925664..3926518 Mycobacterium bovis BCG str. Tokyo 172 7562382 YP_002646619.1 CDS fadD19 NC_012207.1 3927079 3928725 R activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence; acyl-CoA synthetase complement(3927079..3928725) Mycobacterium bovis BCG str. Tokyo 172 7562383 YP_002646620.1 CDS echA19 NC_012207.1 3928799 3929590 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 3928799..3929590 Mycobacterium bovis BCG str. Tokyo 172 7562925 YP_002646621.1 CDS JTY_3581 NC_012207.1 3929686 3930525 D hypothetical protein 3929686..3930525 Mycobacterium bovis BCG str. Tokyo 172 7561530 YP_002646622.1 CDS cyp142b NC_012207.1 3930580 3931161 R In Mycobacterium tuberculosis strain H37Rv, cyp142 exists as a single gene. In Mycobacterium bovis, BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*) splits cyp142 into 2 parts,cyp142a and cyp142b; cytochrome P450 monooxygenase 142 complement(3930580..3931161) Mycobacterium bovis BCG str. Tokyo 172 7564059 YP_002646623.1 CDS cyp142a NC_012207.1 3931158 3931775 R In Mycobacterium tuberculosis strain H37Rv, cyp142 exists as a single gene. In Mycobacterium bovis, BCG Pasteur, and BCG Tokyo, a frameshift due to a single base deletion (C-*) splits cyp142 into 2 parts, cyp142a and cyp142b; cytochrome P450 monooxygenase 142 complement(3931158..3931775) Mycobacterium bovis BCG str. Tokyo 172 7563168 YP_002646624.1 CDS JTY_3584 NC_012207.1 3931804 3932514 D hypothetical protein 3931804..3932514 Mycobacterium bovis BCG str. Tokyo 172 7563167 YP_002646625.1 CDS JTY_3585 NC_012207.1 3932579 3933622 R coenzyme F420-dependent oxidoreductase complement(3932579..3933622) Mycobacterium bovis BCG str. Tokyo 172 7564060 YP_002646626.1 CDS JTY_3586 NC_012207.1 3933775 3934686 D Differs from Rv3521 by 1aa D295N in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 3933775..3934686 Mycobacterium bovis BCG str. Tokyo 172 7564061 YP_002646627.1 CDS JTY_3587 NC_012207.1 3934702 3935766 D Differs from Rv3522 by 1aa I324T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipid-transfer protein 3934702..3935766 Mycobacterium bovis BCG str. Tokyo 172 7564062 YP_002646628.1 CDS JTY_3588 NC_012207.1 3935783 3936967 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 3935783..3936967 Mycobacterium bovis BCG str. Tokyo 172 7564063 YP_002646629.1 CDS JTY_3589 NC_012207.1 3937009 3938040 D hypothetical protein 3937009..3938040 Mycobacterium bovis BCG str. Tokyo 172 7564064 YP_002646630.1 CDS JTY_3590 NC_012207.1 3938054 3938578 R siderophore-binding protein complement(3938054..3938578) Mycobacterium bovis BCG str. Tokyo 172 7564065 YP_002646631.1 CDS JTY_3591 NC_012207.1 3938693 3939853 D oxidoreductase 3938693..3939853 Mycobacterium bovis BCG str. Tokyo 172 7564066 YP_002646632.1 CDS JTY_3592 NC_012207.1 3939859 3940308 D hypothetical protein 3939859..3940308 Mycobacterium bovis BCG str. Tokyo 172 7564067 YP_002646633.1 CDS JTY_3593 NC_012207.1 3940733 3941446 R hypothetical protein complement(3940733..3941446) Mycobacterium bovis BCG str. Tokyo 172 7564068 YP_002646634.1 CDS JTY_3594 NC_012207.1 3942138 3943292 R hypothetical protein complement(3942138..3943292) Mycobacterium bovis BCG str. Tokyo 172 7564069 YP_002646635.1 CDS JTY_3595 NC_012207.1 3943292 3944074 R short chain dehydrogenase complement(3943292..3944074) Mycobacterium bovis BCG str. Tokyo 172 7564070 YP_002646636.1 CDS JTY_3596 NC_012207.1 3944071 3945198 R hypothetical protein complement(3944071..3945198) Mycobacterium bovis BCG str. Tokyo 172 7564071 YP_002646637.1 CDS PPE61 NC_012207.1 3945597 3946817 D PPE family protein 3945597..3946817 Mycobacterium bovis BCG str. Tokyo 172 7564072 YP_002646638.1 CDS PPE62 NC_012207.1 3946959 3948707 R PPE family protein complement(3946959..3948707) Mycobacterium bovis BCG str. Tokyo 172 7560795 YP_002646639.1 CDS JTY_3599 NC_012207.1 3948806 3949846 R catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase complement(3948806..3949846) Mycobacterium bovis BCG str. Tokyo 172 7560796 YP_002646640.1 CDS JTY_3600 NC_012207.1 3949843 3950754 R catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase complement(3949843..3950754) Mycobacterium bovis BCG str. Tokyo 172 7564073 YP_002646641.1 CDS JTY_3601 NC_012207.1 3950765 3951550 R hydratase complement(3950765..3951550) Mycobacterium bovis BCG str. Tokyo 172 7564074 YP_002646642.1 CDS JTY_3602 NC_012207.1 3951623 3953314 D initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione; 3-ketosteroid-delta-1-dehydrogenase 3951623..3953314 Mycobacterium bovis BCG str. Tokyo 172 7564075 YP_002646643.1 CDS JTY_3603 NC_012207.1 3953316 3954176 D dehydrogenase 3953316..3954176 Mycobacterium bovis BCG str. Tokyo 172 7564076 YP_002646644.1 CDS PPE63 NC_012207.1 3954313 3955752 D PPE family protein 3954313..3955752 Mycobacterium bovis BCG str. Tokyo 172 7564077 YP_002646645.1 CDS ltp2 NC_012207.1 3955753 3956913 R lipid-transfer protein complement(3955753..3956913) Mycobacterium bovis BCG str. Tokyo 172 7560797 YP_002646646.1 CDS JTY_3606 NC_012207.1 3956913 3957302 R hypothetical protein complement(3956913..3957302) Mycobacterium bovis BCG str. Tokyo 172 7560539 YP_002646647.1 CDS JTY_3607 NC_012207.1 3957299 3958234 R hypothetical protein complement(3957299..3958234) Mycobacterium bovis BCG str. Tokyo 172 7564078 YP_002646648.1 CDS fadE29 NC_012207.1 3958231 3959394 R acyl-CoA dehydrogenase complement(3958231..3959394) Mycobacterium bovis BCG str. Tokyo 172 7564079 YP_002646649.1 CDS fadE28 NC_012207.1 3959379 3960398 R acyl-CoA dehydrogenase complement(3959379..3960398) Mycobacterium bovis BCG str. Tokyo 172 7563378 YP_002646650.1 CDS cyp125 NC_012207.1 3960398 3961699 R cytochrome P450 125 complement(3960398..3961699) Mycobacterium bovis BCG str. Tokyo 172 7563377 YP_002646651.1 CDS fadA5 NC_012207.1 3961811 3962986 D Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 3961811..3962986 Mycobacterium bovis BCG str. Tokyo 172 7563156 YP_002646652.1 CDS JTY_3612 NC_012207.1 3963098 3963553 D hypothetical protein 3963098..3963553 Mycobacterium bovis BCG str. Tokyo 172 7562908 YP_002646653.1 CDS JTY_3613 NC_012207.1 3963636 3964550 R Differs from Rv3548c by 1aa V218M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; short chain dehydrogenase complement(3963636..3964550) Mycobacterium bovis BCG str. Tokyo 172 7564080 YP_002646654.1 CDS JTY_3614 NC_012207.1 3964573 3965352 R short chain dehydrogenase complement(3964573..3965352) Mycobacterium bovis BCG str. Tokyo 172 7564081 YP_002646655.1 CDS echA20 NC_012207.1 3965407 3966150 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 3965407..3966150 Mycobacterium bovis BCG str. Tokyo 172 7564082 YP_002646656.1 CDS JTY_3616 NC_012207.1 3966150 3967028 D Differs from Rv3551 by 1aa, S7A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; CoA-transferase subunit alpha 3966150..3967028 Mycobacterium bovis BCG str. Tokyo 172 7561532 YP_002646657.1 CDS JTY_3617 NC_012207.1 3967025 3967777 D CoA-transferase subunit beta 3967025..3967777 Mycobacterium bovis BCG str. Tokyo 172 7564083 YP_002646658.1 CDS JTY_3618 NC_012207.1 3967875 3968942 D oxidoreductase 3967875..3968942 Mycobacterium bovis BCG str. Tokyo 172 7564084 YP_002646659.1 CDS fdxB NC_012207.1 3968939 3970996 D electron transfer protein 3968939..3970996 Mycobacterium bovis BCG str. Tokyo 172 7564085 YP_002646660.1 CDS JTY_3620 NC_012207.1 3971084 3971953 R Differs from Rv3555c by 1aa R268W in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(3971084..3971953) Mycobacterium bovis BCG str. Tokyo 172 7563407 YP_002646661.1 CDS fadA6 NC_012207.1 3972058 3973218 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase complement(3972058..3973218) Mycobacterium bovis BCG str. Tokyo 172 7564168 YP_002646662.1 CDS JTY_3622 NC_012207.1 3973283 3973885 R probably TetR-family; transcriptional regulatory protein complement(3973283..3973885) Mycobacterium bovis BCG str. Tokyo 172 7562909 YP_002646663.1 CDS PPE64 NC_012207.1 3974234 3975892 D PPE family protein 3974234..3975892 Mycobacterium bovis BCG str. Tokyo 172 7563676 YP_002646664.1 CDS JTY_3624 NC_012207.1 3975901 3976689 R Differs from Rv3559c by 1aa V222A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; short chain dehydrogenase complement(3975901..3976689) Mycobacterium bovis BCG str. Tokyo 172 7560798 YP_002646665.1 CDS fadE30 NC_012207.1 3976686 3977843 R acyl-CoA dehydrogenase complement(3976686..3977843) Mycobacterium bovis BCG str. Tokyo 172 7563677 YP_002646666.1 CDS fadD3 NC_012207.1 3977891 3979414 D activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 3977891..3979414 Mycobacterium bovis BCG str. Tokyo 172 7563380 YP_002646667.1 CDS fadE31 NC_012207.1 3979415 3980548 D acyl-CoA dehydrogenase 3979415..3980548 Mycobacterium bovis BCG str. Tokyo 172 7562935 YP_002646668.1 CDS fadE32 NC_012207.1 3980545 3981504 D Differs from Rv3563 by 2aa R105Q and S275W in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; acyl-CoA dehydrogenase 3980545..3981504 Mycobacterium bovis BCG str. Tokyo 172 7563381 YP_002646669.1 CDS fadE33 NC_012207.1 3981501 3982457 D acyl-CoA dehydrogenase 3981501..3982457 Mycobacterium bovis BCG str. Tokyo 172 7563382 YP_002646670.1 CDS aspB NC_012207.1 3982454 3983620 D catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 3982454..3983620 Mycobacterium bovis BCG str. Tokyo 172 7563383 YP_002646671.1 CDS nat NC_012207.1 3983585 3984436 R arylamine N-acetyltransferase complement(3983585..3984436) Mycobacterium bovis BCG str. Tokyo 172 7562043 YP_002646672.1 CDS JTY_3632 NC_012207.1 3984421 3984687 R hypothetical protein complement(3984421..3984687) Mycobacterium bovis BCG str. Tokyo 172 7562455 YP_002646673.1 CDS JTY_3633 NC_012207.1 3984973 3985536 R Differs from Rv3567c by 1aa T179I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase complement(3984973..3985536) Mycobacterium bovis BCG str. Tokyo 172 7563678 YP_002646674.1 CDS bphC NC_012207.1 3985551 3986453 R Differs from Mb3599c by 1aa Q177R in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; biphenyl-2,3-diol 1,2-dioxygenase complement(3985551..3986453) Mycobacterium bovis BCG str. Tokyo 172 7563679 YP_002646675.1 CDS bphD NC_012207.1 3986450 3987325 R 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase complement(3986450..3987325) Mycobacterium bovis BCG str. Tokyo 172 7562074 YP_002646676.1 CDS JTY_3636 NC_012207.1 3987340 3988524 R Differs from Rv3570c by 1aa D18N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase complement(3987340..3988524) Mycobacterium bovis BCG str. Tokyo 172 7562075 YP_002646677.1 CDS hmp NC_012207.1 3988671 3989747 D hemoglobine-related protein 3988671..3989747 Mycobacterium bovis BCG str. Tokyo 172 7563680 YP_002646678.1 CDS JTY_3638 NC_012207.1 3989765 3990295 D hypothetical protein 3989765..3990295 Mycobacterium bovis BCG str. Tokyo 172 7563320 YP_002646679.1 CDS fadE34 NC_012207.1 3990331 3992466 R acyl-CoA dehydrogenase complement(3990331..3992466) Mycobacterium bovis BCG str. Tokyo 172 7563681 YP_002646680.1 CDS JTY_3640 NC_012207.1 3992738 3993337 D probably TetR-family; transcriptional regulatory protein 3992738..3993337 Mycobacterium bovis BCG str. Tokyo 172 7563384 YP_002646681.1 CDS JTY_3641 NC_012207.1 3993343 3994422 R probably LacI-family; transcriptional regulatory protein complement(3993343..3994422) Mycobacterium bovis BCG str. Tokyo 172 7563682 YP_002646682.1 CDS lppH NC_012207.1 3994612 3995325 D Differs from Rv3576 by 1aa N118D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 3994612..3995325 Mycobacterium bovis BCG str. Tokyo 172 7563683 YP_002646683.1 CDS JTY_3643 NC_012207.1 3995516 3996382 D hypothetical protein 3995516..3996382 Mycobacterium bovis BCG str. Tokyo 172 7560473 YP_002646684.1 CDS arsB2 NC_012207.1 3996396 3997637 D Differs from Rv3578 by 1aa S319A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; arsenical pump integral membrane protein 3996396..3997637 Mycobacterium bovis BCG str. Tokyo 172 7563684 YP_002646685.1 CDS JTY_3645 NC_012207.1 3997679 3998647 R Differs from Rv3579c by 1aa , A302E in Mycobacterium bovis BCG Pasteur and BCG Tokyo. Mb3610c is longer due to frameshift and differs by 1aa V178M in Mycobacterium bovis.; tRNA/rRNA methyltransferase complement(3997679..3998647) Mycobacterium bovis BCG str. Tokyo 172 7562037 YP_002646686.1 CDS cysS NC_012207.1 3998648 4000057 R catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase complement(3998648..4000057) Mycobacterium bovis BCG str. Tokyo 172 7563685 YP_002646687.1 CDS ispF NC_012207.1 4000122 4000601 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(4000122..4000601) Mycobacterium bovis BCG str. Tokyo 172 7563183 YP_002646688.1 CDS ispD NC_012207.1 4000598 4001293 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(4000598..4001293) Mycobacterium bovis BCG str. Tokyo 172 7562796 YP_002646689.1 CDS JTY_3649 NC_012207.1 4001310 4001798 R Differs from Rv3583 by 1 aa, R13H in BCG Tokyo.; transcription factor complement(4001310..4001798) Mycobacterium bovis BCG str. Tokyo 172 7562794 YP_002646690.1 CDS lpqE NC_012207.1 4002083 4002631 D lipoprotein 4002083..4002631 Mycobacterium bovis BCG str. Tokyo 172 7563686 YP_002646691.1 CDS radA NC_012207.1 4002697 4004139 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 4002697..4004139 Mycobacterium bovis BCG str. Tokyo 172 7560497 YP_002646692.1 CDS JTY_3652 NC_012207.1 4004144 4005220 D non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair; DNA integrity scanning protein DisA 4004144..4005220 Mycobacterium bovis BCG str. Tokyo 172 7561549 YP_002646693.1 CDS JTY_3653 NC_012207.1 4005221 4006012 R Shorter than Rv3587c and Mb3618c by 1aa, P at 240 in BCG Pasteur and BCG Tokyo; hypothetical protein complement(4005221..4006012) Mycobacterium bovis BCG str. Tokyo 172 7563687 YP_002646694.1 CDS canB NC_012207.1 4006121 4006744 R Differs from Mb3619c by 1aa I79T in Mycobacterium tuberculosis, BCG Pasteur, and BCG Tokyo; carbonic anhydrase complement(4006121..4006744) Mycobacterium bovis BCG str. Tokyo 172 7563688 YP_002646695.1 CDS mutY NC_012207.1 4006743 4007657 D adenine glycosylase 4006743..4007657 Mycobacterium bovis BCG str. Tokyo 172 7562081 YP_002646696.1 CDS PE_PGRS58 NC_012207.1 4007654 4009408 R PE-PGRS family protein complement(4007654..4009408) Mycobacterium bovis BCG str. Tokyo 172 7563584 YP_002646697.1 CDS JTY_3657 NC_012207.1 4009519 4010292 R hydrolase complement(4009519..4010292) Mycobacterium bovis BCG str. Tokyo 172 7562384 YP_002646698.1 CDS TB11.2 NC_012207.1 4010307 4010624 D hypothetical protein 4010307..4010624 Mycobacterium bovis BCG str. Tokyo 172 7563689 YP_002646699.1 CDS lpqF NC_012207.1 4010602 4011960 D Differs from Rv3593 by 2 aa, V159A, S186N in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; lipoprotein 4010602..4011960 Mycobacterium bovis BCG str. Tokyo 172 7561827 YP_002646700.1 CDS JTY_3660 NC_012207.1 4012107 4012934 D hypothetical protein 4012107..4012934 Mycobacterium bovis BCG str. Tokyo 172 7560498 YP_002646701.1 CDS PE_PGRS59 NC_012207.1 4012848 4014326 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base deletion (a-*) and a 27bp insertion (*-GCGCGCCGGGGCCACCGTTTCCGCCGG), lead to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (492 aa versus 439 aa); PE-PGRS family protein complement(4012848..4014326) Mycobacterium bovis BCG str. Tokyo 172 7563690 YP_002646702.1 CDS clpC NC_012207.1 4014434 4016980 R ATP-dependent Clp protease ATP-binding subunit complement(4014434..4016980) Mycobacterium bovis BCG str. Tokyo 172 7562385 YP_002646703.1 CDS lsr2 NC_012207.1 4017257 4017595 R lsr2 protein precursor complement(4017257..4017595) Mycobacterium bovis BCG str. Tokyo 172 7562108 YP_002646704.1 CDS lysS NC_012207.1 4017699 4019216 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(4017699..4019216) Mycobacterium bovis BCG str. Tokyo 172 7560537 YP_002646705.1 CDS JTY_3665 NC_012207.1 4019317 4020135 R type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase complement(4019317..4020135) Mycobacterium bovis BCG str. Tokyo 172 7560542 YP_002646706.1 CDS panD NC_012207.1 4020138 4020557 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(4020138..4020557) Mycobacterium bovis BCG str. Tokyo 172 7563691 YP_002646707.1 CDS panC NC_012207.1 4020557 4021486 R catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase complement(4020557..4021486) Mycobacterium bovis BCG str. Tokyo 172 7562510 YP_002646708.1 CDS JTY_3668 NC_012207.1 4021483 4022394 R hypothetical alanine and leucine rich protein complement(4021483..4022394) Mycobacterium bovis BCG str. Tokyo 172 7562509 YP_002646709.1 CDS JTY_3669 NC_012207.1 4022579 4023772 R Differs from Rv3604c by G153V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein rich in alanine and arginine and proline complement(4022579..4023772) Mycobacterium bovis BCG str. Tokyo 172 7563692 YP_002646710.1 CDS JTY_3670 NC_012207.1 4023981 4024457 R hypothetical protein complement(4023981..4024457) Mycobacterium bovis BCG str. Tokyo 172 7563693 YP_002646711.1 CDS folK NC_012207.1 4024457 4025023 R 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase complement(4024457..4025023) Mycobacterium bovis BCG str. Tokyo 172 7563694 YP_002646712.1 CDS folB NC_012207.1 4025020 4025421 R dihydroneopterin aldolase complement(4025020..4025421) Mycobacterium bovis BCG str. Tokyo 172 7563423 YP_002646713.1 CDS folP1 NC_012207.1 4025414 4026256 R dihydropteroate synthase 1 complement(4025414..4026256) Mycobacterium bovis BCG str. Tokyo 172 7563419 YP_002646714.1 CDS folE NC_012207.1 4026253 4026861 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(4026253..4026861) Mycobacterium bovis BCG str. Tokyo 172 7563424 YP_002646715.1 CDS ftsH NC_012207.1 4026877 4029159 R membrane-bound protease complement(4026877..4029159) Mycobacterium bovis BCG str. Tokyo 172 7563422 YP_002646716.1 CDS JTY_3676 NC_012207.1 4029226 4029768 D Identical to Rv3611 in BCG Pasteur. In Mycobacterium bovis and BCG Tokyo, a 111bp deletion leads to a shorter product compared to its homolog in Mycobacterium tuberculosis (180 aa versus 217aa).; hypothetical arginine and proline rich protein 4029226..4029768 Mycobacterium bovis BCG str. Tokyo 172 7561877 YP_002646717.1 CDS JTY_3677 NC_012207.1 4029683 4030012 R hypothetical protein complement(4029683..4030012) Mycobacterium bovis BCG str. Tokyo 172 7563695 YP_002646718.1 CDS JTY_3678 NC_012207.1 4030046 4030207 R hypothetical protein complement(4030046..4030207) Mycobacterium bovis BCG str. Tokyo 172 7563696 YP_002646719.1 CDS JTY_3679 NC_012207.1 4030307 4030861 R hypothetical protein complement(4030307..4030861) Mycobacterium bovis BCG str. Tokyo 172 7563697 YP_002646720.1 CDS JTY_3680 NC_012207.1 4030977 4031288 R hypothetical protein complement(4030977..4031288) Mycobacterium bovis BCG str. Tokyo 172 7563698 YP_002646721.1 CDS JTY_3681 NC_012207.1 4031362 4032540 R Differs from Rv3616c by 2aa, V4A, I192T and Mb3646c by 2aa, V4A, V153A in BCG Pasteur and BCG Tokyo; hypothetical alanine and glycine rich protein complement(4031362..4032540) Mycobacterium bovis BCG str. Tokyo 172 7563699 YP_002646722.1 CDS lpqG NC_012207.1 4033006 4033521 D In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a large 5894 bp deletion (RD8) leads to a shorter product with a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (171 aa versus 240 aa); lipoprotein 4033006..4033521 Mycobacterium bovis BCG str. Tokyo 172 7563700 YP_002646723.1 CDS hpt NC_012207.1 4033526 4034176 R Differs by 2 aa from Rv3624c et Mb3648c A111T, N122D in Mycobacterium bovis BCG Pasteur. Differs by 1 aa from Rv3624c et Mb3648c A111T in Mycobacterium bovis BCG Tokyo.; hypoxanthine-guanine phosphoribosyltransferase complement(4033526..4034176) Mycobacterium bovis BCG str. Tokyo 172 7560499 YP_002646724.1 CDS mesJ NC_012207.1 4034173 4035144 R cell cycle protein complement(4034173..4035144) Mycobacterium bovis BCG str. Tokyo 172 7563322 YP_002646725.1 CDS JTY_3685 NC_012207.1 4035123 4036175 R hypothetical protein complement(4035123..4036175) Mycobacterium bovis BCG str. Tokyo 172 7564455 YP_002646726.1 CDS JTY_3686 NC_012207.1 4036172 4037557 R Differs from Rv3627c by 2 aa, V45A, V81A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(4036172..4037557) Mycobacterium bovis BCG str. Tokyo 172 7563701 YP_002646727.1 CDS ppa NC_012207.1 4037695 4038183 D inorganic pyrophosphatase 4037695..4038183 Mycobacterium bovis BCG str. Tokyo 172 7563702 YP_002646728.1 CDS JTY_3688 NC_012207.1 4038229 4039326 R hypothetical protein complement(4038229..4039326) Mycobacterium bovis BCG str. Tokyo 172 7562142 YP_002646729.1 CDS JTY_3689 NC_012207.1 4039447 4040742 D Differs from Rv3630 by 1aa, T40A in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane protein 4039447..4040742 Mycobacterium bovis BCG str. Tokyo 172 7563703 YP_002646730.1 CDS JTY_3690 NC_012207.1 4040786 4041511 D possibly glycosyltransferase; transferase 4040786..4041511 Mycobacterium bovis BCG str. Tokyo 172 7563704 YP_002646731.1 CDS JTY_3691 NC_012207.1 4041508 4041852 D hypothetical protein 4041508..4041852 Mycobacterium bovis BCG str. Tokyo 172 7563705 YP_002646732.1 CDS JTY_3692 NC_012207.1 4042063 4042938 D hypothetical protein 4042063..4042938 Mycobacterium bovis BCG str. Tokyo 172 7563706 YP_002646733.1 CDS galE1 NC_012207.1 4042939 4043883 R UDP-glucose 4-epimerase complement(4042939..4043883) Mycobacterium bovis BCG str. Tokyo 172 7563707 YP_002646734.1 CDS JTY_3694 NC_012207.1 4043906 4045681 D transmembrane protein 4043906..4045681 Mycobacterium bovis BCG str. Tokyo 172 7561896 YP_002646735.1 CDS JTY_3695 NC_012207.1 4046024 4046371 D transposase 4046024..4046371 Mycobacterium bovis BCG str. Tokyo 172 7563708 YP_002646736.1 CDS JTY_3696 NC_012207.1 4046756 4047256 D transposase 4046756..4047256 Mycobacterium bovis BCG str. Tokyo 172 7563709 YP_002646737.1 CDS JTY_3697 NC_012207.1 4047256 4048002 D transposase 4047256..4048002 Mycobacterium bovis BCG str. Tokyo 172 7563710 YP_002646738.1 CDS JTY_3698 NC_012207.1 4048156 4048722 R Differs from Rv3639c by 1 aa, N53K in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein complement(4048156..4048722) Mycobacterium bovis BCG str. Tokyo 172 7563711 YP_002646739.1 CDS JTY_3699 NC_012207.1 4048792 4050021 R Differs from Rv3640c by 1aa, E296G in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; transposase complement(4048792..4050021) Mycobacterium bovis BCG str. Tokyo 172 7563712 YP_002646740.1 CDS fic NC_012207.1 4050197 4050832 R cell filamentation protein complement(4050197..4050832) Mycobacterium bovis BCG str. Tokyo 172 7563713 YP_002646741.1 CDS JTY_3701 NC_012207.1 4050843 4051037 R hypothetical protein complement(4050843..4051037) Mycobacterium bovis BCG str. Tokyo 172 7563414 YP_002646742.1 CDS JTY_3702 NC_012207.1 4051432 4051623 D hypothetical protein 4051432..4051623 Mycobacterium bovis BCG str. Tokyo 172 7563714 YP_002646743.1 CDS JTY_3703 NC_012207.1 4051788 4052993 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' complement(4051788..4052993) Mycobacterium bovis BCG str. Tokyo 172 7561855 YP_002646744.1 CDS JTY_3704 NC_012207.1 4053079 4054728 D transmembrane protein 4053079..4054728 Mycobacterium bovis BCG str. Tokyo 172 7563716 YP_002646745.1 CDS topA NC_012207.1 4054725 4057529 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I complement(4054725..4057529) Mycobacterium bovis BCG str. Tokyo 172 7563717 YP_002646746.1 CDS JTY_3706 NC_012207.1 4057882 4058460 R hypothetical protein complement(4057882..4058460) Mycobacterium bovis BCG str. Tokyo 172 7561863 YP_002646747.1 CDS cspA NC_012207.1 4058600 4058803 R cold shock protein A complement(4058600..4058803) Mycobacterium bovis BCG str. Tokyo 172 7563718 YP_002646748.1 CDS JTY_3708 NC_012207.1 4059053 4061368 D Differs from Rv3649 by 2aa, P93L, D677G, and from Mb3673 by D677G in BCG Pasteur and BCG Tokyo; helicase 4059053..4061368 Mycobacterium bovis BCG str. Tokyo 172 7563124 YP_002646749.1 CDS PE33 NC_012207.1 4061505 4061789 D PE family protein 4061505..4061789 Mycobacterium bovis BCG str. Tokyo 172 7563719 YP_002646750.1 CDS JTY_3710 NC_012207.1 4062113 4063150 D hypothetical protein 4062113..4063150 Mycobacterium bovis BCG str. Tokyo 172 7561732 YP_002646751.1 CDS PE_PGRS60 NC_012207.1 4063904 4064218 D PE-PGRS family protein 4063904..4064218 Mycobacterium bovis BCG str. Tokyo 172 7563720 YP_002646752.1 CDS PE_PGRS61 NC_012207.1 4064212 4064907 D In Mycobacterium tuberculosis strain H37Rv, a frameshift due to an in-frame insertion of 126 bp leads to a longer product than in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo. Shorter than Mb3677 due to 18 bp in-frame deletion, removes 6 codons; PE-PGRS family protein 4064212..4064907 Mycobacterium bovis BCG str. Tokyo 172 7562386 YP_002646753.1 CDS JTY_3713 NC_012207.1 4065024 4065278 R hypothetical protein complement(4065024..4065278) Mycobacterium bovis BCG str. Tokyo 172 7562387 YP_002646754.1 CDS JTY_3714 NC_012207.1 4065364 4065663 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base deletion (c-*) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (99 aa versus 125 aa); hypothetical protein complement(4065364..4065663) Mycobacterium bovis BCG str. Tokyo 172 7563721 YP_002646755.1 CDS JTY_3715 NC_012207.1 4065687 4065893 R hypothetical protein complement(4065687..4065893) Mycobacterium bovis BCG str. Tokyo 172 7563722 YP_002646756.1 CDS JTY_3716 NC_012207.1 4065903 4066478 R alanine rich membrane protein complement(4065903..4066478) Mycobacterium bovis BCG str. Tokyo 172 7563723 YP_002646757.1 CDS JTY_3717 NC_012207.1 4066502 4067302 R transmembrane protein complement(4066502..4067302) Mycobacterium bovis BCG str. Tokyo 172 7563724 YP_002646758.1 CDS JTY_3718 NC_012207.1 4067299 4068357 R hypothetical protein complement(4067299..4068357) Mycobacterium bovis BCG str. Tokyo 172 7563725 YP_002646759.1 CDS JTY_3719 NC_012207.1 4068459 4069511 R Differs from Rv3660c by 1aa, L30P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(4068459..4069511) Mycobacterium bovis BCG str. Tokyo 172 7563726 YP_002646760.1 CDS JTY_3720 NC_012207.1 4070011 4070874 D Differs from Rv3661 by 1aa, P40S in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4070011..4070874 Mycobacterium bovis BCG str. Tokyo 172 7563727 YP_002646761.1 CDS JTY_3721 NC_012207.1 4071629 4072399 R Differs from Rv3662c by 1aa, T34A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(4071629..4072399) Mycobacterium bovis BCG str. Tokyo 172 7563728 YP_002646762.1 CDS dppD NC_012207.1 4072396 4074042 R dipeptide-transport ATP-binding protein ABC transporter complement(4072396..4074042) Mycobacterium bovis BCG str. Tokyo 172 7563729 YP_002646763.1 CDS dppC NC_012207.1 4074039 4074839 R dipeptide-transport integral membrane protein ABC transporter complement(4074039..4074839) Mycobacterium bovis BCG str. Tokyo 172 7561513 YP_002646764.1 CDS dppB NC_012207.1 4074895 4075821 R dipeptide-transport integral membrane protein ABC transporter complement(4074895..4075821) Mycobacterium bovis BCG str. Tokyo 172 7561512 YP_002646765.1 CDS dppA NC_012207.1 4075823 4077448 R Differs from Rv3666c by 2aa, R4Q, Q443R and to Mb3690c by 1aa, E451G in BCG Pasteur and BCG Tokyo; periplasmic dipeptide-binding lipoprotein complement(4075823..4077448) Mycobacterium bovis BCG str. Tokyo 172 7561511 YP_002646766.1 CDS JTY_3727 NC_012207.1 4080146 4080844 R protease complement(4080146..4080844) Mycobacterium bovis BCG str. Tokyo 172 7563935 YP_002646767.1 CDS JTY_3728 NC_012207.1 4081190 4081708 D transmembrane protein 4081190..4081708 Mycobacterium bovis BCG str. Tokyo 172 7563730 YP_002646768.1 CDS ephE NC_012207.1 4081709 4082692 D epoxide hydrolase 4081709..4082692 Mycobacterium bovis BCG str. Tokyo 172 7563731 YP_002646769.1 CDS JTY_3730 NC_012207.1 4082685 4083878 R Differs from Rv3671c by 3aa, T165N, L359F, V363I and from Mb3695c by 3aa, T165N and L359F in BCG Pasteur and BCG Tokyo; membrane-associated serine protease complement(4082685..4083878) Mycobacterium bovis BCG str. Tokyo 172 7562870 YP_002646770.1 CDS JTY_3731 NC_012207.1 4083884 4084705 R hypothetical protein complement(4083884..4084705) Mycobacterium bovis BCG str. Tokyo 172 7563732 YP_002646771.1 CDS JTY_3732 NC_012207.1 4084837 4085520 R membrane-anchored thioredoxin-like protein complement(4084837..4085520) Mycobacterium bovis BCG str. Tokyo 172 7563733 YP_002646772.1 CDS nth NC_012207.1 4085520 4086257 R endonuclease III complement(4085520..4086257) Mycobacterium bovis BCG str. Tokyo 172 7563734 YP_002646773.1 CDS JTY_3734 NC_012207.1 4086365 4086742 D hypothetical protein 4086365..4086742 Mycobacterium bovis BCG str. Tokyo 172 7562472 YP_002646774.1 CDS JTY_3735 NC_012207.1 4086841 4087515 D Differs from Rv3676 and Mb 3700 by 2aa, P47L, K178E in Mycobacterium bovis BCG Pasteur. Differs from Rv3676 and Mb3700 by 2aa, E178K, V184A in Mycobacterium bovis BCG Tokyo; probably crp/fnr-family; transcriptional regulatory protein 4086841..4087515 Mycobacterium bovis BCG str. Tokyo 172 7563735 YP_002646775.1 CDS JTY_3736 NC_012207.1 4087621 4088415 R hydrolase complement(4087621..4088415) Mycobacterium bovis BCG str. Tokyo 172 7563736 YP_002646776.1 CDS JTY_3737 NC_012207.1 4088422 4088877 R hypothetical protein complement(4088422..4088877) Mycobacterium bovis BCG str. Tokyo 172 7563737 YP_002646777.1 CDS JTY_3738 NC_012207.1 4088893 4089054 R hypothetical protein complement(4088893..4089054) Mycobacterium bovis BCG str. Tokyo 172 7563738 YP_002646778.1 CDS JTY_3739 NC_012207.1 4089139 4090161 D anion transporter ATPase 4089139..4090161 Mycobacterium bovis BCG str. Tokyo 172 7563739 YP_002646779.1 CDS JTY_3740 NC_012207.1 4090158 4091318 D anion transporter ATPase 4090158..4091318 Mycobacterium bovis BCG str. Tokyo 172 7563740 YP_002646780.1 CDS whiB4 NC_012207.1 4091561 4091917 R transcriptional regulatory protein whiB-like complement(4091561..4091917) Mycobacterium bovis BCG str. Tokyo 172 7563741 YP_002646781.1 CDS ponA2 NC_012207.1 4092279 4094711 D bifunctional membrane-associated penicillin-binding protein 1A/1B 4092279..4094711 Mycobacterium bovis BCG str. Tokyo 172 7561692 YP_002646782.1 CDS JTY_3743 NC_012207.1 4094780 4095739 D hypothetical protein 4094780..4095739 Mycobacterium bovis BCG str. Tokyo 172 7562141 YP_002646783.1 CDS JTY_3744 NC_012207.1 4095802 4096842 D lyase 4095802..4096842 Mycobacterium bovis BCG str. Tokyo 172 7563742 YP_002646784.1 CDS cyp137 NC_012207.1 4097658 4099088 R Differs from Rv3685c by 1aa, Q136E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo; cytochrome P450 137 complement(4097658..4099088) Mycobacterium bovis BCG str. Tokyo 172 7560833 YP_002646785.1 CDS JTY_3746 NC_012207.1 4099114 4099446 R hypothetical protein complement(4099114..4099446) Mycobacterium bovis BCG str. Tokyo 172 7563163 YP_002646786.1 CDS JTY_3747 NC_012207.1 4099686 4099931 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, truncation at the 5' start due to a single base transversion (G-T) leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (81 aa versus 122 aa); hypothetical protein complement(4099686..4099931) Mycobacterium bovis BCG str. Tokyo 172 7563744 YP_002646787.1 CDS JTY_3748 NC_012207.1 4100256 4100720 R hypothetical protein complement(4100256..4100720) Mycobacterium bovis BCG str. Tokyo 172 7563745 YP_002646788.1 CDS JTY_3749 NC_012207.1 4100720 4102075 D Differs from Rv3689 by 1aa, L119V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 4100720..4102075 Mycobacterium bovis BCG str. Tokyo 172 7563746 YP_002646789.1 CDS JTY_3750 NC_012207.1 4102102 4102755 D hypothetical protein 4102102..4102755 Mycobacterium bovis BCG str. Tokyo 172 7563747 YP_002646790.1 CDS JTY_3751 NC_012207.1 4102881 4103882 D hypothetical protein 4102881..4103882 Mycobacterium bovis BCG str. Tokyo 172 7563748 YP_002646791.1 CDS moxR2 NC_012207.1 4103879 4104955 D methanol dehydrogenase transcriptional regulatory protein 4103879..4104955 Mycobacterium bovis BCG str. Tokyo 172 7563749 YP_002646792.1 CDS JTY_3753 NC_012207.1 4105089 4106411 D Differs from Rv3693 by 2aa, V178L, P214A in BCG Tokyo.; hypothetical protein 4105089..4106411 Mycobacterium bovis BCG str. Tokyo 172 7563548 YP_002646793.1 CDS JTY_3754 NC_012207.1 4106485 4107477 R transmembrane protein complement(4106485..4107477) Mycobacterium bovis BCG str. Tokyo 172 7563750 YP_002646794.1 CDS JTY_3755 NC_012207.1 4107569 4108501 D hypothetical protein 4107569..4108501 Mycobacterium bovis BCG str. Tokyo 172 7563751 YP_002646795.1 CDS glpK NC_012207.1 4108565 4110121 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(4108565..4110121) Mycobacterium bovis BCG str. Tokyo 172 7563752 YP_002646796.1 CDS JTY_3757 NC_012207.1 4110171 4110608 R Differs from Rv3697c by 1aa, R34G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(4110171..4110608) Mycobacterium bovis BCG str. Tokyo 172 7561941 YP_002646797.1 CDS JTY_3758 NC_012207.1 4110605 4110829 R hypothetical protein complement(4110605..4110829) Mycobacterium bovis BCG str. Tokyo 172 7563753 YP_002646798.1 CDS JTY_3759 NC_012207.1 4110859 4112388 D Differs from Rv3698 by 3aa, I66M, R233P, A288V and from Mb3724 by 1aa, A288V in BCG Pasteur and BCG Tokyo; hypothetical protein 4110859..4112388 Mycobacterium bovis BCG str. Tokyo 172 7563754 YP_002646799.1 CDS JTY_3760 NC_012207.1 4112410 4113111 D hypothetical protein 4112410..4113111 Mycobacterium bovis BCG str. Tokyo 172 7563755 YP_002646800.1 CDS JTY_3761 NC_012207.1 4113114 4114286 R hypothetical protein complement(4113114..4114286) Mycobacterium bovis BCG str. Tokyo 172 7563756 YP_002646801.1 CDS JTY_3762 NC_012207.1 4114317 4115282 R hypothetical protein complement(4114317..4115282) Mycobacterium bovis BCG str. Tokyo 172 7563757 YP_002646802.1 CDS JTY_3763 NC_012207.1 4115279 4115980 R hypothetical protein complement(4115279..4115980) Mycobacterium bovis BCG str. Tokyo 172 7562610 YP_002646803.1 CDS JTY_3764 NC_012207.1 4115980 4117257 R hypothetical protein complement(4115980..4117257) Mycobacterium bovis BCG str. Tokyo 172 7562611 YP_002646804.1 CDS gshA NC_012207.1 4117254 4118552 R gamma-glutamylcystein synthetase, gamma-ECS, GCS, gamma-glutamyl-L-cysteine synthetase; glutamate--cysteine ligase GshA complement(4117254..4118552) Mycobacterium bovis BCG str. Tokyo 172 7562612 YP_002646805.1 CDS JTY_3766 NC_012207.1 4118684 4119328 R hypothetical protein complement(4118684..4119328) Mycobacterium bovis BCG str. Tokyo 172 7563286 YP_002646806.1 CDS JTY_3767 NC_012207.1 4119457 4119846 R hypothetical protein complement(4119457..4119846) Mycobacterium bovis BCG str. Tokyo 172 7562613 YP_002646807.1 CDS JTY_3768 NC_012207.1 4119957 4120277 R hypothetical protein complement(4119957..4120277) Mycobacterium bovis BCG str. Tokyo 172 7562614 YP_002646808.1 CDS JTY_3769 NC_012207.1 4120396 4121406 R hypothetical protein complement(4120396..4121406) Mycobacterium bovis BCG str. Tokyo 172 7562615 YP_002646809.1 CDS asd NC_012207.1 4121546 4122583 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(4121546..4122583) Mycobacterium bovis BCG str. Tokyo 172 7562616 YP_002646810.1 CDS ask NC_012207.1 4122584 4123849 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase complement(4122584..4123849) Mycobacterium bovis BCG str. Tokyo 172 7562039 YP_002646811.1 CDS leuA NC_012207.1 4124106 4126553 D Protein is 190 aa longer than Rv3710, and 57 aalonger than Mb3737 due to differences in copy number of 19codon repeat at 3'-end; 2-isopropylmalate synthase 4124106..4126553 Mycobacterium bovis BCG str. Tokyo 172 7562040 YP_002646812.1 CDS dnaQ NC_012207.1 4126619 4127608 R 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon complement(4126619..4127608) Mycobacterium bovis BCG str. Tokyo 172 7562813 YP_002646813.1 CDS JTY_3774 NC_012207.1 4127742 4128983 D Differs from Rv3712 by 2aa, S200G, T351K in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; ligase 4127742..4128983 Mycobacterium bovis BCG str. Tokyo 172 7561508 YP_002646814.1 CDS cobQ2 NC_012207.1 4128988 4129683 D cobyric acid synthase 4128988..4129683 Mycobacterium bovis BCG str. Tokyo 172 7562617 YP_002646815.1 CDS JTY_3776 NC_012207.1 4129692 4130582 R hypothetical protein complement(4129692..4130582) Mycobacterium bovis BCG str. Tokyo 172 7563116 YP_002646816.1 CDS recR NC_012207.1 4130650 4131261 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(4130650..4131261) Mycobacterium bovis BCG str. Tokyo 172 7562618 YP_002646817.1 CDS JTY_3778 NC_012207.1 4131273 4131674 R hypothetical protein complement(4131273..4131674) Mycobacterium bovis BCG str. Tokyo 172 7561562 YP_002646818.1 CDS JTY_3779 NC_012207.1 4131809 4132534 D hypothetical protein 4131809..4132534 Mycobacterium bovis BCG str. Tokyo 172 7562619 YP_002646819.1 CDS JTY_3780 NC_012207.1 4132576 4133019 R hypothetical protein complement(4132576..4133019) Mycobacterium bovis BCG str. Tokyo 172 7562620 YP_002646820.1 CDS JTY_3781 NC_012207.1 4133067 4134479 D Differs from Rv3719 by 1aa, A12T in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4133067..4134479 Mycobacterium bovis BCG str. Tokyo 172 7562621 YP_002646821.1 CDS JTY_3782 NC_012207.1 4134497 4135759 D fatty acid synthase 4134497..4135759 Mycobacterium bovis BCG str. Tokyo 172 7562622 YP_002646822.1 CDS dnaZX NC_012207.1 4135756 4137492 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau complement(4135756..4137492) Mycobacterium bovis BCG str. Tokyo 172 7562623 YP_002646823.1 CDS JTY_3784 NC_012207.1 4137582 4138889 R Differs from Rv3722c and Mb3749c by 1aa, Y314H in BCG Pasteur and BCG Tokyo; hypothetical protein complement(4137582..4138889) Mycobacterium bovis BCG str. Tokyo 172 7561509 YP_002646824.1 CDS JTY_3785 NC_012207.1 4139297 4140061 D transmembrane protein 4139297..4140061 Mycobacterium bovis BCG str. Tokyo 172 7560787 YP_002646825.1 CDS cut5 NC_012207.1 4140228 4140929 D In Mycobacterium tuberculosis, Rv3724A and Rv3724B exist as 2 genes with an overlap region between them. In Mycobacterium bovis, and Mycobacterium bovis BCG Pasteur, a single base deletion (T-*) leads to a single product; cutinase precursor 4140228..4140929 Mycobacterium bovis BCG str. Tokyo 172 7562625 YP_002646826.1 CDS JTY_3787 NC_012207.1 4140974 4141975 D In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base insertion (*-A) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis (333 aa versus 309 aa); oxidoreductase 4140974..4141975 Mycobacterium bovis BCG str. Tokyo 172 7563146 YP_002646827.1 CDS JTY_3788 NC_012207.1 4142182 4143375 D Differs from Rv3726 by 1aa, S251R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; dehydrogenase 4142182..4143375 Mycobacterium bovis BCG str. Tokyo 172 7562626 YP_002646828.1 CDS JTY_3789 NC_012207.1 4143716 4145524 D Differs from Rv3727 by 1aa, M86V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 4143716..4145524 Mycobacterium bovis BCG str. Tokyo 172 7562627 YP_002646829.1 CDS JTY_3790 NC_012207.1 4145634 4148831 D Differs from Rv3728 by 1aa, R464G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; two-domain membrane protein 4145634..4148831 Mycobacterium bovis BCG str. Tokyo 172 7562628 YP_002646830.1 CDS JTY_3791 NC_012207.1 4149046 4151376 D Differs from Rv3729 by 2aa, I170V, S269P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transferase 4149046..4151376 Mycobacterium bovis BCG str. Tokyo 172 7562629 YP_002646831.1 CDS JTY_3792 NC_012207.1 4151441 4152481 R hypothetical protein complement(4151441..4152481) Mycobacterium bovis BCG str. Tokyo 172 7562630 YP_002646832.1 CDS ligC NC_012207.1 4152519 4153595 D catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth; ATP-dependent DNA ligase 4152519..4153595 Mycobacterium bovis BCG str. Tokyo 172 7562631 YP_002646833.1 CDS JTY_3794 NC_012207.1 4153695 4154753 D hypothetical protein 4153695..4154753 Mycobacterium bovis BCG str. Tokyo 172 7562828 YP_002646834.1 CDS JTY_3795 NC_012207.1 4154773 4155273 R hypothetical protein complement(4154773..4155273) Mycobacterium bovis BCG str. Tokyo 172 7562632 YP_002646835.1 CDS JTY_3796 NC_012207.1 4155287 4156651 R hypothetical protein complement(4155287..4156651) Mycobacterium bovis BCG str. Tokyo 172 7562633 YP_002646836.1 CDS JTY_3797 NC_012207.1 4156850 4157338 D hypothetical protein 4156850..4157338 Mycobacterium bovis BCG str. Tokyo 172 7562634 YP_002646837.1 CDS JTY_3798 NC_012207.1 4157395 4158456 D Differs from Rv3736 and Mb3763 by 1aa, K76E in BCG Pasteur and BCG Tokyo.; probably AraC/XylS-family; transcriptional regulatory protein 4157395..4158456 Mycobacterium bovis BCG str. Tokyo 172 7562635 YP_002646838.1 CDS JTY_3799 NC_012207.1 4158460 4160049 D Differs from Rv3737 by 1aa, G40D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; transmembrane protein 4158460..4160049 Mycobacterium bovis BCG str. Tokyo 172 7562636 YP_002646839.1 CDS JTY_3801 NC_012207.1 4160428 4161774 R Differs from Rv3740c by 1aa, C422R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; hypothetical protein complement(4160428..4161774) Mycobacterium bovis BCG str. Tokyo 172 7560799 YP_002646840.1 CDS JTY_3802 NC_012207.1 4161774 4162448 R oxidoreductase complement(4161774..4162448) Mycobacterium bovis BCG str. Tokyo 172 7562638 YP_002646841.1 CDS JTY_3803 NC_012207.1 4162445 4162840 R oxidoreductase complement(4162445..4162840) Mycobacterium bovis BCG str. Tokyo 172 7562639 YP_002646842.1 CDS ctpJ NC_012207.1 4162986 4164968 R cation transporter P-type ATPase complement(4162986..4164968) Mycobacterium bovis BCG str. Tokyo 172 7562640 YP_002646843.1 CDS JTY_3805 NC_012207.1 4165035 4165397 D probably ArsR-family; transcriptional regulatory protein 4165035..4165397 Mycobacterium bovis BCG str. Tokyo 172 7563140 YP_002646844.1 CDS JTY_3806 NC_012207.1 4165481 4165693 R hypothetical protein complement(4165481..4165693) Mycobacterium bovis BCG str. Tokyo 172 7562641 YP_002646845.1 CDS PE34 NC_012207.1 4165766 4166101 R PE family protein complement(4165766..4166101) Mycobacterium bovis BCG str. Tokyo 172 7562642 YP_002646846.1 CDS JTY_3808 NC_012207.1 4166319 4166702 D hypothetical protein 4166319..4166702 Mycobacterium bovis BCG str. Tokyo 172 7561733 YP_002646847.1 CDS JTY_3809 NC_012207.1 4166832 4167191 D Differs from Rv3748 by 1aa, D107G in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; hypothetical protein 4166832..4167191 Mycobacterium bovis BCG str. Tokyo 172 7562643 YP_002646848.1 CDS JTY_3810 NC_012207.1 4167224 4167733 R hypothetical protein complement(4167224..4167733) Mycobacterium bovis BCG str. Tokyo 172 7562644 YP_002646849.1 CDS JTY_3811 NC_012207.1 4167801 4168193 R excisionase complement(4167801..4168193) Mycobacterium bovis BCG str. Tokyo 172 7562645 YP_002646850.1 CDS JTY_3812 NC_012207.1 4168469 4168684 D integrase 4168469..4168684 Mycobacterium bovis BCG str. Tokyo 172 7562646 YP_002646851.1 CDS JTY_3813 NC_012207.1 4168842 4169300 R cytidine/deoxycytidylate deaminase complement(4168842..4169300) Mycobacterium bovis BCG str. Tokyo 172 7560788 YP_002646852.1 CDS JTY_3814 NC_012207.1 4169316 4169837 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and Mycobacterium bovis, a single base transition (t-c) leads to a longer product with a different 5' start compared to its homolog in Mycobacterium tuberculosis strain H37Rv(173 aa versus 166 aa); hypothetical protein complement(4169316..4169837) Mycobacterium bovis BCG str. Tokyo 172 7562648 YP_002646853.1 CDS tyrA NC_012207.1 4170016 4170921 D catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 4170016..4170921 Mycobacterium bovis BCG str. Tokyo 172 7562649 YP_002646854.1 CDS JTY_3816 NC_012207.1 4170884 4171483 R hypothetical protein complement(4170884..4171483) Mycobacterium bovis BCG str. Tokyo 172 7561646 YP_002646855.1 CDS proZ NC_012207.1 4171489 4172208 R osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter complement(4171489..4172208) Mycobacterium bovis BCG str. Tokyo 172 7562650 YP_002646856.1 CDS proW NC_012207.1 4172205 4172894 R osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport integral membrane protein ABC transporter complement(4172205..4172894) Mycobacterium bovis BCG str. Tokyo 172 7560834 YP_002646857.1 CDS proV NC_012207.1 4172882 4174012 R osmoprotectant (glycine betaine/carnitine/choline/L-proline) transport ATP-binding protein ABC transporter complement(4172882..4174012) Mycobacterium bovis BCG str. Tokyo 172 7560831 YP_002646858.1 CDS proX NC_012207.1 4174021 4174968 R Differs from Rv3759c by 2aa, P85L, V176A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; osmoprotectant (glycine betaine/carnitine/choline/L-proline) binding lipoprotein complement(4174021..4174968) Mycobacterium bovis BCG str. Tokyo 172 7560830 YP_002646859.1 CDS JTY_3821 NC_012207.1 4175133 4175435 D hypothetical protein 4175133..4175435 Mycobacterium bovis BCG str. Tokyo 172 7560832 YP_002646860.1 CDS fadE36 NC_012207.1 4175457 4176512 R acyl-CoA dehydrogenase complement(4175457..4176512) Mycobacterium bovis BCG str. Tokyo 172 7562651 YP_002646861.1 CDS JTY_3823 NC_012207.1 4176591 4178471 R Differs from Rv3762c by 1aa, H345Y and from Mb3788c by 1aa, V161G in BCG Pasteur and BCG Tokyo; hydrolase complement(4176591..4178471) Mycobacterium bovis BCG str. Tokyo 172 7563386 YP_002646862.1 CDS lpqH NC_012207.1 4178642 4179121 D 19 kDa lipoprotein antigen precursor 4178642..4179121 Mycobacterium bovis BCG str. Tokyo 172 7562652 YP_002646863.1 CDS JTY_3825 NC_012207.1 4179177 4180604 R Differs from Rv3764c by 2aa, R45H, R246C in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; two component sensor kinase complement(4179177..4180604) Mycobacterium bovis BCG str. Tokyo 172 7560500 YP_002646864.1 CDS JTY_3826 NC_012207.1 4180675 4181379 R two component transcriptional regulatory protein complement(4180675..4181379) Mycobacterium bovis BCG str. Tokyo 172 7562653 YP_002646865.1 CDS JTY_3827 NC_012207.1 4181888 4182577 D hypothetical protein 4181888..4182577 Mycobacterium bovis BCG str. Tokyo 172 7562654 YP_002646866.1 CDS JTY_3828 NC_012207.1 4182591 4183535 R hypothetical protein complement(4182591..4183535) Mycobacterium bovis BCG str. Tokyo 172 7562655 YP_002646867.1 CDS JTY_3829 NC_012207.1 4183665 4184024 D hypothetical protein 4183665..4184024 Mycobacterium bovis BCG str. Tokyo 172 7562656 YP_002646868.1 CDS JTY_3830 NC_012207.1 4184210 4184482 D hypothetical protein 4184210..4184482 Mycobacterium bovis BCG str. Tokyo 172 7562657 YP_002646869.1 CDS JTY_3831 NC_012207.1 4184795 4185370 R Differs from Rv3770c by 1aa, A98P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur and BCG Tokyo.; hypothetical leucine rich protein complement(4184795..4185370) Mycobacterium bovis BCG str. Tokyo 172 7562658 YP_002646870.1 CDS JTY_3832 NC_012207.1 4185476 4185658 R remnant of a transposase complement(4185476..4185658) Mycobacterium bovis BCG str. Tokyo 172 7562659 YP_002646871.1 CDS JTY_3833 NC_012207.1 4185673 4185864 R remnant of a transposase complement(4185673..4185864) Mycobacterium bovis BCG str. Tokyo 172 7562660 YP_002646872.1 CDS JTY_3834 NC_012207.1 4185999 4186325 R hypothetical protein complement(4185999..4186325) Mycobacterium bovis BCG str. Tokyo 172 7562661 YP_002646873.1 CDS hisC2 NC_012207.1 4186729 4187790 D Differs from Rv3772 by 1aa, A142T in Mycobacterium bovis, BCG Pasteur and BCG Tokyo.; aminotransferase 4186729..4187790 Mycobacterium bovis BCG str. Tokyo 172 7560785 YP_002646874.1 CDS JTY_3836 NC_012207.1 4187836 4188180 R In Mycobacterium tuberculosis Rv3773c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, BCG Tokyo, a frameshift due to a single base insertion (*-A) splits Rv3773c in two parts; hypothetical protein complement(4187836..4188180) Mycobacterium bovis BCG str. Tokyo 172 7563311 YP_002646875.1 CDS JTY_3837 NC_012207.1 4188185 4188421 R In Mycobacterium tuberculosis strain H37Rv, Rv3773c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-A) splits Rv3773c into 2 parts; hypothetical protein complement(4188185..4188421) Mycobacterium bovis BCG str. Tokyo 172 7562663 YP_002646876.1 CDS echA21 NC_012207.1 4188445 4189269 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 4188445..4189269 Mycobacterium bovis BCG str. Tokyo 172 7562664 YP_002646877.1 CDS lipE NC_012207.1 4189281 4190528 D lipase 4189281..4190528 Mycobacterium bovis BCG str. Tokyo 172 7561533 YP_002646879.1 CDS JTY_3841 NC_012207.1 4192290 4193276 D Differs from Rv3777 by 1aa, A160V in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; oxidoreductase 4192290..4193276 Mycobacterium bovis BCG str. Tokyo 172 7560786 YP_002646880.1 CDS JTY_3842 NC_012207.1 4193295 4194491 R aminotransferase complement(4193295..4194491) Mycobacterium bovis BCG str. Tokyo 172 7562665 YP_002646881.1 CDS JTY_3843 NC_012207.1 4194581 4196581 D transmembrane protein alanine and leucine rich 4194581..4196581 Mycobacterium bovis BCG str. Tokyo 172 7562666 YP_002646882.1 CDS JTY_3844 NC_012207.1 4196585 4197121 D hypothetical protein 4196585..4197121 Mycobacterium bovis BCG str. Tokyo 172 7562667 YP_002646883.1 CDS rbfE NC_012207.1 4197125 4197946 D O-antigen/lipopolysaccharide transport ATP-binding protein ABC transporter 4197125..4197946 Mycobacterium bovis BCG str. Tokyo 172 7562668 YP_002646884.1 CDS JTY_3846 NC_012207.1 4197943 4198857 D L-rhamnosyltransferase 4197943..4198857 Mycobacterium bovis BCG str. Tokyo 172 7561551 YP_002646885.1 CDS rfbD NC_012207.1 4198854 4199696 D O-antigen/lipopolysaccharide transport integral membrane protein ABC transporter 4198854..4199696 Mycobacterium bovis BCG str. Tokyo 172 7562669 YP_002646886.1 CDS rfbB NC_012207.1 4199852 4200832 D dTDP-glucose 4,6-dehydratase 4199852..4200832 Mycobacterium bovis BCG str. Tokyo 172 7561567 YP_002646887.1 CDS JTY_3849 NC_012207.1 4200916 4201989 D hypothetical protein 4200916..4201989 Mycobacterium bovis BCG str. Tokyo 172 7561566 YP_002646888.1 CDS JTY_3850 NC_012207.1 4201970 4203193 R hypothetical protein complement(4201970..4203193) Mycobacterium bovis BCG str. Tokyo 172 7562670 YP_002646889.1 CDS JTY_3851 NC_012207.1 4203206 4204132 R hypothetical protein complement(4203206..4204132) Mycobacterium bovis BCG str. Tokyo 172 7562671 YP_002646890.1 CDS JTY_3852 NC_012207.1 4204376 4204861 D Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 4204376..4204861 Mycobacterium bovis BCG str. Tokyo 172 7562672 YP_002646891.1 CDS JTY_3853 NC_012207.1 4204970 4205335 D hypothetical protein 4204970..4205335 Mycobacterium bovis BCG str. Tokyo 172 7562673 YP_002646892.1 CDS JTY_3854 NC_012207.1 4205375 4206760 D oxidoreductase 4205375..4206760 Mycobacterium bovis BCG str. Tokyo 172 7562674 YP_002646893.1 CDS JTY_3855 NC_012207.1 4206761 4207525 D short chain dehydrogenase 4206761..4207525 Mycobacterium bovis BCG str. Tokyo 172 7562675 YP_002646894.1 CDS JTY_3856 NC_012207.1 4207528 4209459 D transmembrane protein 4207528..4209459 Mycobacterium bovis BCG str. Tokyo 172 7562676 YP_002646895.1 CDS embC NC_012207.1 4209459 4212743 D Differs from Rv3793 by 1aa, I270T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; indolylacetylinositol arabinosyltransferase 4209459..4212743 Mycobacterium bovis BCG str. Tokyo 172 7562677 YP_002646896.1 CDS embA NC_012207.1 4212829 4216113 D indolylacetylinositol arabinosyltransferase 4212829..4216113 Mycobacterium bovis BCG str. Tokyo 172 7562859 YP_002646897.1 CDS embB NC_012207.1 4216110 4219406 D Differs from Rv3795 by 2aa, S13N, A378E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; indolylacetylinositol arabinosyltransferase 4216110..4219406 Mycobacterium bovis BCG str. Tokyo 172 7562857 YP_002646898.1 CDS JTY_3860 NC_012207.1 4219474 4220601 D Differs from Rv3796 by 1aa, I320T in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein 4219474..4220601 Mycobacterium bovis BCG str. Tokyo 172 7562858 YP_002646899.1 CDS fadE35 NC_012207.1 4220681 4222462 D acyl-CoA dehydrogenase 4220681..4222462 Mycobacterium bovis BCG str. Tokyo 172 7562678 YP_002646900.1 CDS JTY_3862 NC_012207.1 4222589 4223923 D In Mycobacterium tuberculosis strain H37Rv (Rv3798), Mycobacterium bovis BCG Pasteur (BCG_3860), and BCG Tokyo, exist as a single gene. In Mycobacterium bovis, a frameshift due to a 11 bp deletion splits Rv3798 into 2 parts, Mb3827 and Mb3828. In Mycobacterium bovis, a frameshift due to a 11 bp deletion splits Rv3798 into 2 parts, Mb3827 and Mb3828; transposase 4222589..4223923 Mycobacterium bovis BCG str. Tokyo 172 7563385 YP_002646901.1 CDS accD4 NC_012207.1 4223976 4225544 R propionyl-CoA carboxylase beta chain 4 complement(4223976..4225544) Mycobacterium bovis BCG str. Tokyo 172 7562679 YP_002646902.1 CDS pks13 NC_012207.1 4225541 4230742 R Differs from Rv3800c by 2aa, G523A, N650S and from Mb3829c by 1aa, N650S in BCG Pasteur and BCG Tokyo; polyketide synthase complement(4225541..4230742) Mycobacterium bovis BCG str. Tokyo 172 7563924 YP_002646903.1 CDS fadD32 NC_012207.1 4230749 4232662 R activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(4230749..4232662) Mycobacterium bovis BCG str. Tokyo 172 7562444 YP_002646904.1 CDS JTY_3866 NC_012207.1 4232951 4233961 R hypothetical protein complement(4232951..4233961) Mycobacterium bovis BCG str. Tokyo 172 7563348 YP_002646905.1 CDS fbpD NC_012207.1 4234159 4235058 R MPT51/MPB51 antigen protein complement(4234159..4235058) Mycobacterium bovis BCG str. Tokyo 172 7562680 YP_002646906.1 CDS fbpA NC_012207.1 4235238 4236254 R antigen 85-A complement(4235238..4236254) Mycobacterium bovis BCG str. Tokyo 172 7563403 YP_002646907.1 CDS JTY_3869 NC_012207.1 4236549 4238432 R Differs from Rv3805c by 1aa, V327I in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein complement(4236549..4238432) Mycobacterium bovis BCG str. Tokyo 172 7563400 YP_002646908.1 CDS JTY_3870 NC_012207.1 4238521 4239429 R catalyzes the formation of decaprenylphosphoryl-5-phosphoribose from phosphoribose diphosphate and decaprenyl phosphate; phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase complement(4238521..4239429) Mycobacterium bovis BCG str. Tokyo 172 7562681 YP_002646909.1 CDS JTY_3871 NC_012207.1 4239436 4239933 R transmembrane protein complement(4239436..4239933) Mycobacterium bovis BCG str. Tokyo 172 7562682 YP_002646910.1 CDS JTY_3872 NC_012207.1 4239962 4241875 R galactofuranosyl transferase complement(4239962..4241875) Mycobacterium bovis BCG str. Tokyo 172 7562683 YP_002646911.1 CDS glf NC_012207.1 4241872 4243071 R UDP-galactopyranose mutase complement(4241872..4243071) Mycobacterium bovis BCG str. Tokyo 172 7562684 YP_002646912.1 CDS pirG NC_012207.1 4243335 4244189 D exported repetitive protein precursor 4243335..4244189 Mycobacterium bovis BCG str. Tokyo 172 7561919 YP_002646913.1 CDS JTY_3875 NC_012207.1 4244394 4246013 D hypothetical protein 4244394..4246013 Mycobacterium bovis BCG str. Tokyo 172 7562425 YP_002646914.1 CDS PE_PGRS62 NC_012207.1 4246167 4247681 D PE-PGRS family protein 4246167..4247681 Mycobacterium bovis BCG str. Tokyo 172 7562685 YP_002646915.1 CDS JTY_3877 NC_012207.1 4247990 4248811 R Differs from Rv3813c by 1aa, T83M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(4247990..4248811) Mycobacterium bovis BCG str. Tokyo 172 7562388 YP_002646916.1 CDS JTY_3878 NC_012207.1 4248826 4249608 R 3-bp:GGC deletion in BCG Tokyo after (188-190):GGC of Rv3814c; acyltransferase complement(4248826..4249608) Mycobacterium bovis BCG str. Tokyo 172 7562686 YP_002646917.1 CDS JTY_3879 NC_012207.1 4249626 4250381 R acyltransferase complement(4249626..4250381) Mycobacterium bovis BCG str. Tokyo 172 7562687 YP_002646918.1 CDS JTY_3880 NC_012207.1 4250385 4251164 R acyltransferase complement(4250385..4251164) Mycobacterium bovis BCG str. Tokyo 172 7562688 YP_002646919.1 CDS JTY_3881 NC_012207.1 4251240 4251995 D phosphotransferase 4251240..4251995 Mycobacterium bovis BCG str. Tokyo 172 7562689 YP_002646920.1 CDS JTY_3882 NC_012207.1 4252042 4253592 D hypothetical protein 4252042..4253592 Mycobacterium bovis BCG str. Tokyo 172 7562690 YP_002646921.1 CDS JTY_3883 NC_012207.1 4253589 4253924 D hypothetical protein 4253589..4253924 Mycobacterium bovis BCG str. Tokyo 172 7562691 YP_002646922.1 CDS papA2 NC_012207.1 4254012 4255418 R Differs from Rv3820c by 1aa, I463T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; polyketide synthase associated protein complement(4254012..4255418) Mycobacterium bovis BCG str. Tokyo 172 7564251 YP_002646923.1 CDS JTY_3885 NC_012207.1 4255566 4256279 D Differs from Rv3821 by 2aa, N106D, T120A; integral membrane protein 4255566..4256279 Mycobacterium bovis BCG str. Tokyo 172 7562512 YP_002646924.1 CDS JTY_3886 NC_012207.1 4256314 4256682 D Corresponds to Rv3822/Mb3852 but is missing 1bp after codon 122. Differs from Rv3822 by 2aa, Y55C, T103N, in first part (and by 1aa, V92A, in the second part); hypothetical protein 4256314..4256682 Mycobacterium bovis BCG str. Tokyo 172 7564252 YP_002646925.1 CDS JTY_3887 NC_012207.1 4256679 4257527 D Corresponds to 3'-part of Rv3822/Mb3852 due to missing bp after codon 122. Differs from Rv3822 by 1aa, V92A (and by 2aa, Y55C, T105N, in first part); hypothetical protein 4256679..4257527 Mycobacterium bovis BCG str. Tokyo 172 7564253 YP_002646926.1 CDS mmpL8 NC_012207.1 4257852 4261121 R Differs from Rv3823c by 2aa, R235G, A526V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; integral membrane transport protein complement(4257852..4261121) Mycobacterium bovis BCG str. Tokyo 172 7564254 YP_002646927.1 CDS papA1 NC_012207.1 4261231 4262766 R polyketide synthase associated protein complement(4261231..4262766) Mycobacterium bovis BCG str. Tokyo 172 7564493 YP_002646928.1 CDS pks2 NC_012207.1 4262817 4269197 R Differs from Rv3825c and Mb3855c by 1aa, G829V in BCG Pasteur and BCG Tokyo; polyketide synthase complement(4262817..4269197) Mycobacterium bovis BCG str. Tokyo 172 7562511 YP_002646929.1 CDS fadD23 NC_012207.1 4269404 4271158 D activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 4269404..4271158 Mycobacterium bovis BCG str. Tokyo 172 7562119 YP_002646930.1 CDS JTY_3892 NC_012207.1 4271155 4272381 R Differs from Rv3827c by 1aa, A251T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transposase complement(4271155..4272381) Mycobacterium bovis BCG str. Tokyo 172 7562929 YP_002646931.1 CDS JTY_3893 NC_012207.1 4272378 4272989 R resolvase complement(4272378..4272989) Mycobacterium bovis BCG str. Tokyo 172 7564255 YP_002646932.1 CDS JTY_3894 NC_012207.1 4272990 4274600 R Differs from Rv3829c by 1aa, D55E in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; dehydrogenase complement(4272990..4274600) Mycobacterium bovis BCG str. Tokyo 172 7564256 YP_002646933.1 CDS JTY_3895 NC_012207.1 4274648 4275277 R probably TetR-family; transcriptional regulatory protein complement(4274648..4275277) Mycobacterium bovis BCG str. Tokyo 172 7564257 YP_002646934.1 CDS JTY_3896 NC_012207.1 4275349 4275831 D hypothetical protein 4275349..4275831 Mycobacterium bovis BCG str. Tokyo 172 7564258 YP_002646935.1 CDS JTY_3897 NC_012207.1 4275828 4276403 R hypothetical protein complement(4275828..4276403) Mycobacterium bovis BCG str. Tokyo 172 7564259 YP_002646936.1 CDS JTY_3898 NC_012207.1 4276459 4277250 D Differs from Rv3833 by 1aa, I105V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; probably AraC-family; transcriptional regulatory protein 4276459..4277250 Mycobacterium bovis BCG str. Tokyo 172 7564260 YP_002646937.1 CDS serS NC_012207.1 4277247 4278506 R catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase complement(4277247..4278506) Mycobacterium bovis BCG str. Tokyo 172 7564261 YP_002646938.1 CDS JTY_3900 NC_012207.1 4278639 4279988 D Differs from Rv3835 and Mb3865 by 1 aa, Y79N in BCG Pasteur and BCG Tokyo, and frameshift due to extra C in C-string that changes C-terminus in BCG Pasteur.; hypothetical protein 4278639..4279988 Mycobacterium bovis BCG str. Tokyo 172 7560784 YP_002646939.1 CDS JTY_3901 NC_012207.1 4279993 4280343 D In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base insertion (*-G) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (116 aa versus 137 aa); hypothetical protein 4279993..4280343 Mycobacterium bovis BCG str. Tokyo 172 7564262 YP_002646940.1 CDS JTY_3902 NC_012207.1 4280602 4281300 R phosphoglycerate mutase complement(4280602..4281300) Mycobacterium bovis BCG str. Tokyo 172 7564263 YP_002646941.1 CDS pheA NC_012207.1 4281297 4282262 R catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase complement(4281297..4282262) Mycobacterium bovis BCG str. Tokyo 172 7564264 YP_002646942.1 CDS JTY_3904 NC_012207.1 4282358 4283134 D Differs from Rv3839 by 1aa, S122P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4282358..4283134 Mycobacterium bovis BCG str. Tokyo 172 7562404 YP_002646943.1 CDS JTY_3905 NC_012207.1 4283160 4283573 D transcriptional regulatory protein 4283160..4283573 Mycobacterium bovis BCG str. Tokyo 172 7564265 YP_002646944.1 CDS bfrB NC_012207.1 4283771 4284316 D bacterioferritin 4283771..4284316 Mycobacterium bovis BCG str. Tokyo 172 7564266 YP_002646945.1 CDS glpQ1 NC_012207.1 4284331 4285155 R glycerophosphoryl diester phosphodiesterase complement(4284331..4285155) Mycobacterium bovis BCG str. Tokyo 172 7562064 YP_002646946.1 CDS JTY_3908 NC_012207.1 4285161 4286189 R Differs from Rv3843c by 2aa, R11G, H92R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein complement(4285161..4286189) Mycobacterium bovis BCG str. Tokyo 172 7561942 YP_002646947.1 CDS JTY_3909 NC_012207.1 4288367 4288858 D transposase 4288367..4288858 Mycobacterium bovis BCG str. Tokyo 172 7564267 YP_002646948.1 CDS JTY_3910 NC_012207.1 4288873 4289232 D hypothetical protein 4288873..4289232 Mycobacterium bovis BCG str. Tokyo 172 7564268 YP_002646949.1 CDS sodA NC_012207.1 4290296 4290919 D Differs from Rv3846 by 1aa, T205I; Fe-superoxide dismutase 4290296..4290919 Mycobacterium bovis BCG str. Tokyo 172 7564269 YP_002646950.1 CDS JTY_3912 NC_012207.1 4291130 4291663 D hypothetical protein 4291130..4291663 Mycobacterium bovis BCG str. Tokyo 172 7561802 YP_002646951.1 CDS JTY_3913 NC_012207.1 4291918 4292826 D Differs from Rv3848 by 1aa, I194V in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; transmembrane protein 4291918..4292826 Mycobacterium bovis BCG str. Tokyo 172 7564270 YP_002646952.1 CDS JTY_3914 NC_012207.1 4293091 4293489 D hypothetical protein 4293091..4293489 Mycobacterium bovis BCG str. Tokyo 172 7564271 YP_002646953.1 CDS JTY_3915 NC_012207.1 4293607 4294263 D hypothetical protein 4293607..4294263 Mycobacterium bovis BCG str. Tokyo 172 7564272 YP_002646954.1 CDS JTY_3916 NC_012207.1 4294275 4294559 D hypothetical protein 4294275..4294559 Mycobacterium bovis BCG str. Tokyo 172 7564273 YP_002646955.1 CDS hns NC_012207.1 4294666 4295070 D histone-like protein 4294666..4295070 Mycobacterium bovis BCG str. Tokyo 172 7564274 YP_002646956.1 CDS menG NC_012207.1 4295087 4295560 D regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 4295087..4295560 Mycobacterium bovis BCG str. Tokyo 172 7563321 YP_002646957.1 CDS ethA NC_012207.1 4295596 4297065 R monooxygenase complement(4295596..4297065) Mycobacterium bovis BCG str. Tokyo 172 7564454 YP_002646958.1 CDS ethR NC_012207.1 4297141 4297791 D TetR-family; transcriptional regulatory repressor protein 4297141..4297791 Mycobacterium bovis BCG str. Tokyo 172 7562892 YP_002646959.1 CDS JTY_3921 NC_012207.1 4297993 4299000 R hypothetical protein complement(4297993..4299000) Mycobacterium bovis BCG str. Tokyo 172 7562893 YP_002646960.1 CDS JTY_3922 NC_012207.1 4299009 4299206 R hypothetical protein complement(4299009..4299206) Mycobacterium bovis BCG str. Tokyo 172 7564275 YP_002646961.1 CDS gltD NC_012207.1 4299631 4301097 R glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta complement(4299631..4301097) Mycobacterium bovis BCG str. Tokyo 172 7564276 YP_002646962.1 CDS gltB NC_012207.1 4301090 4305673 R Differs from Rv3859c by 1aa, E553Q in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; ferredoxin-dependent glutamate synthase [NADPH] large subunit complement(4301090..4305673) Mycobacterium bovis BCG str. Tokyo 172 7561948 YP_002646963.1 CDS JTY_3925 NC_012207.1 4306369 4307430 D In Mycobacterium bovis BCG Pasteur and BCG Tokyo, a single base deletion leads to a shorter product compared to its homologs in Mycobacterium tuberculosis and Mycobacterium bovis; hypothetical protein 4306369..4307430 Mycobacterium bovis BCG str. Tokyo 172 7561947 YP_002646964.1 CDS JTY_3926 NC_012207.1 4307537 4307863 D hypothetical protein 4307537..4307863 Mycobacterium bovis BCG str. Tokyo 172 7564277 YP_002646965.1 CDS whiB6 NC_012207.1 4307762 4308112 R transcriptional regulatory protein WhiB-like complement(4307762..4308112) Mycobacterium bovis BCG str. Tokyo 172 7564278 YP_002646966.1 CDS JTY_3928 NC_012207.1 4308439 4309617 D hypothetical alanine rich protein 4308439..4309617 Mycobacterium bovis BCG str. Tokyo 172 7561694 YP_002646967.1 CDS JTY_3929 NC_012207.1 4309860 4311116 D In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and in Mycobacterium bovis, two in-frame insertion of 36 and 12bp, leads to a longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (418 aa versus 402 aa); hypothetical protein 4309860..4311116 Mycobacterium bovis BCG str. Tokyo 172 7564279 YP_002646968.1 CDS JTY_3930 NC_012207.1 4311204 4311515 D hypothetical protein 4311204..4311515 Mycobacterium bovis BCG str. Tokyo 172 7564280 YP_002646969.1 CDS JTY_3931 NC_012207.1 4311518 4312369 D hypothetical protein 4311518..4312369 Mycobacterium bovis BCG str. Tokyo 172 7564281 YP_002646970.1 CDS JTY_3932 NC_012207.1 4312408 4312959 D hypothetical protein 4312408..4312959 Mycobacterium bovis BCG str. Tokyo 172 7564282 YP_002646971.1 CDS JTY_3933 NC_012207.1 4312952 4314673 D Differs from Rv3868 by 1aa, V243A in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein 4312952..4314673 Mycobacterium bovis BCG str. Tokyo 172 7564283 YP_002646972.1 CDS JTY_3934 NC_012207.1 4314677 4316119 D hypothetical protein 4314677..4316119 Mycobacterium bovis BCG str. Tokyo 172 7564284 YP_002646973.1 CDS JTY_3935 NC_012207.1 4316119 4318362 D hypothetical protein 4316119..4318362 Mycobacterium bovis BCG str. Tokyo 172 7564285 YP_002646974.1 CDS JTY_3936 NC_012207.1 4318465 4319937 D Differs from Rv3871 and Mb3901 by deletion of 101 codons after codon 480 due to BCG-specific RD1 deletion; hypothetical protein 4318465..4319937 Mycobacterium bovis BCG str. Tokyo 172 7564286 YP_002646975.1 CDS JTY_3937 NC_012207.1 4320380 4320727 R hypothetical protein complement(4320380..4320727) Mycobacterium bovis BCG str. Tokyo 172 7564287 YP_002646976.1 CDS JTY_3938 NC_012207.1 4320724 4322106 R Differs from Rv3881c by 7 codon stretch due to 1bp deletion and 1 bp insertion in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical alanine and glycine rich protein complement(4320724..4322106) Mycobacterium bovis BCG str. Tokyo 172 7564288 YP_002646977.1 CDS JTY_3939 NC_012207.1 4322213 4323601 R hypothetical protein complement(4322213..4323601) Mycobacterium bovis BCG str. Tokyo 172 7564289 YP_002646978.1 CDS JTY_3940 NC_012207.1 4323598 4324938 R Differs from Rv3883c by 1aa, A37T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; protease complement(4323598..4324938) Mycobacterium bovis BCG str. Tokyo 172 7564290 YP_002646979.1 CDS JTY_3941 NC_012207.1 4325160 4327019 R Differs from Rv3884c by 1aa, G215E in Mycobacterium tuberculosis CDC1551, Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; CbxX/CfqX family protein complement(4325160..4327019) Mycobacterium bovis BCG str. Tokyo 172 7564291 YP_002646980.1 CDS JTY_3942 NC_012207.1 4327089 4328702 R Differs from Rv3885c by 1aa, P133L in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(4327089..4328702) Mycobacterium bovis BCG str. Tokyo 172 7564292 YP_002646981.1 CDS JTY_3943 NC_012207.1 4328699 4330351 R alanine and proline rich protease complement(4328699..4330351) Mycobacterium bovis BCG str. Tokyo 172 7564293 YP_002646982.1 CDS JTY_3944 NC_012207.1 4330336 4331865 R transmembrane protein complement(4330336..4331865) Mycobacterium bovis BCG str. Tokyo 172 7564294 YP_002646983.1 CDS JTY_3945 NC_012207.1 4331862 4332524 R Has no counterpart in Mycobacterium bovis owing to deletion of 2405bp between positions 4307384..4307385; hypothetical protein complement(4331862..4332524) Mycobacterium bovis BCG str. Tokyo 172 7564295 YP_002646984.1 CDS JTY_3946 NC_012207.1 4332521 4332886 R Has no counterpart in Mycobacterium bovis owing to deletion of 2405bp between positions 364165-364166; hypothetical protein complement(4332521..4332886) Mycobacterium bovis BCG str. Tokyo 172 7564296 YP_002646985.1 CDS JTY_3947 NC_012207.1 4332980 4333810 R In Mycobacterium bovis, a deletion of 2406 bases leads to the loss of the NH2 part of Rv3887c, the entire Rv3888c and the COOH part of Rv3889c compared to Mycobacterium tuberculosis strain H37Rv and Mycobacterium bovis BCG Pasteur; hypothetical protein complement(4332980..4333810) Mycobacterium bovis BCG str. Tokyo 172 7564297 YP_002646986.1 CDS esxC NC_012207.1 4333818 4334192 R In Mycobacterium bovis BCG Pasteur, BCG Tokyo, and in Mycobacterium bovis, a frameshift due to a single base deletion (C-*) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (124 aa versus 95 aa); EsaT-6 like protein 11 complement(4333818..4334192) Mycobacterium bovis BCG str. Tokyo 172 7564298 YP_002646987.1 CDS esxD NC_012207.1 4334228 4334551 R Differs from Rv3891c by 1aa, A49T in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(4334228..4334551) Mycobacterium bovis BCG str. Tokyo 172 7562874 YP_002646988.1 CDS PPE69 NC_012207.1 4334662 4335861 R Differs from Rv3892c by 2aa, K19T, I206M and from Mb3921c by 1aa I206M in BCG Pasteur and BCG Tokyo; PPE family protein complement(4334662..4335861) Mycobacterium bovis BCG str. Tokyo 172 7562875 YP_002646989.1 CDS PE36 NC_012207.1 4335940 4336173 R PE family protein complement(4335940..4336173) Mycobacterium bovis BCG str. Tokyo 172 7560800 YP_002646990.1 CDS JTY_3952 NC_012207.1 4336440 4338125 R In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-C), splits Rv3894c into 2 parts; hypothetical protein complement(4336440..4338125) Mycobacterium bovis BCG str. Tokyo 172 7561734 YP_002646991.1 CDS JTY_3953 NC_012207.1 4338130 4340631 R In Mycobacterium tuberculosis, Rv3894c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a frameshift due to a single base insertion (*-C), splits Rv3894c into 2 parts. Differs from first part of Rv3984c by 1aa, P258R in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; hypothetical protein complement(4338130..4340631) Mycobacterium bovis BCG str. Tokyo 172 7564299 YP_002646992.1 CDS JTY_3954 NC_012207.1 4340632 4342119 R Differs from Rv3895c by 1aa, G356D in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(4340632..4342119) Mycobacterium bovis BCG str. Tokyo 172 7564300 YP_002646993.1 CDS JTY_3955 NC_012207.1 4342163 4343029 R Differs from Rv3896c by 3aa, G83D, V186I, K193Q, and by frameshift due to 1bp deletion leading to shorter product (288 aa versus 302 aa) in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(4342163..4343029) Mycobacterium bovis BCG str. Tokyo 172 7564301 YP_002646994.1 CDS JTY_3956 NC_012207.1 4343179 4344168 R In Mycobacterium tuberculosis, Rv3898c and Rv3897c exist as 2 genes. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo, a single base transition (T-C) leads to a single product; hypothetical protein complement(4343179..4344168) Mycobacterium bovis BCG str. Tokyo 172 7564302 YP_002646995.1 CDS JTY_3957 NC_012207.1 4344330 4345211 R In Mycobacterium tuberculosis, Rv3899c exists as a single gene. In Mycobacterium bovis, Mycobacterium bovis BCG Pasteur , and BCG Tokyo, a frameshift due to a single base deletion (C-*) splits Rv3899c into 2 parts, Mb3928c and Mb3929c with the former being the more likely product; hypothetical protein complement(4344330..4345211) Mycobacterium bovis BCG str. Tokyo 172 7564303 YP_002646996.1 CDS JTY_3959 NC_012207.1 4345555 4346490 R Differs from Rv3900c by 1aa, A18P in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical alanine rich protein complement(4345555..4346490) Mycobacterium bovis BCG str. Tokyo 172 7564305 YP_002646997.1 CDS JTY_3960 NC_012207.1 4346599 4346994 R Differs from Rv3901c by 1aa, W21L, and frameshift due to 2bp deletion at 3'-end, and from Mb3931c by frameshift only in BCG Pasteur and BCG Tokyo; hypothetical protein complement(4346599..4346994) Mycobacterium bovis BCG str. Tokyo 172 7564306 YP_002646998.1 CDS JTY_3961 NC_012207.1 4347545 4348075 R hypothetical protein complement(4347545..4348075) Mycobacterium bovis BCG str. Tokyo 172 7564307 YP_002646999.1 CDS JTY_3962 NC_012207.1 4348072 4350612 R hypothetical alanine and proline rich protein complement(4348072..4350612) Mycobacterium bovis BCG str. Tokyo 172 7564308 YP_002647000.1 CDS esxE NC_012207.1 4350617 4350889 R Differs from Rv3904c by 1aa, V82M in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; EsaT-6 like protein 12 complement(4350617..4350889) Mycobacterium bovis BCG str. Tokyo 172 7564309 YP_002647001.1 CDS esxF NC_012207.1 4351038 4351211 R In Mycobacterium bovis, and Mycobacteium bovis BCG Pasteur, and BCG Tokyo, a single base transition (G-A) introducing a premature stop codon, leads to a shorter product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (57 aa versus 103 aa); EsaT-6 like protein 13 complement(4351038..4351211) Mycobacterium bovis BCG str. Tokyo 172 7562876 YP_002647002.1 CDS JTY_3965 NC_012207.1 4351277 4351786 R hypothetical protein complement(4351277..4351786) Mycobacterium bovis BCG str. Tokyo 172 7562877 YP_002647003.1 CDS pcnA NC_012207.1 4351811 4353253 R poly(A) polymerase complement(4351811..4353253) Mycobacterium bovis BCG str. Tokyo 172 7564310 YP_002647004.1 CDS JTY_3967 NC_012207.1 4353629 4354375 D hypothetical protein 4353629..4354375 Mycobacterium bovis BCG str. Tokyo 172 7562524 YP_002647005.1 CDS JTY_3968 NC_012207.1 4354372 4356780 D Differs from Rv3909 by 3aa, R7G, S399N, V538A and from Mb3939 by 1aa G25A in BCG Pasteur and BCG Tokyo; hypothetical protein 4354372..4356780 Mycobacterium bovis BCG str. Tokyo 172 7564311 YP_002647006.1 CDS JTY_3969 NC_012207.1 4356777 4360331 D Differs from Rv3910 by 1aa, A480V in Mycobacterium bovis, BCG Pasteur, and BCG Tokyo; transmembrane protein 4356777..4360331 Mycobacterium bovis BCG str. Tokyo 172 7564312 YP_002647007.1 CDS sigMa NC_012207.1 4360366 4360956 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase; RNA polymerase sigma factor SigM 4360366..4360956 Mycobacterium bovis BCG str. Tokyo 172 7564313 YP_002647008.1 CDS JTY_3972 NC_012207.1 4361049 4361813 D hypothetical alanine rich protein 4361049..4361813 Mycobacterium bovis BCG str. Tokyo 172 7561798 YP_002647009.1 CDS trxB2 NC_012207.1 4361907 4362914 D Differs from Rv3913 by 1aa, G57D; thioredoxin reductase 4361907..4362914 Mycobacterium bovis BCG str. Tokyo 172 7564314 YP_002647010.1 CDS trxC NC_012207.1 4362911 4363261 D thioredoxin 4362911..4363261 Mycobacterium bovis BCG str. Tokyo 172 7561640 YP_002647011.1 CDS JTY_3975 NC_012207.1 4363371 4364591 D hydrolase 4363371..4364591 Mycobacterium bovis BCG str. Tokyo 172 7561641 YP_002647012.1 CDS JTY_3976 NC_012207.1 4364612 4365346 R hypothetical protein complement(4364612..4365346) Mycobacterium bovis BCG str. Tokyo 172 7564315 YP_002647013.1 CDS parB NC_012207.1 4365636 4366670 R chromosome partitioning protein complement(4365636..4366670) Mycobacterium bovis BCG str. Tokyo 172 7564316 YP_002647014.1 CDS parA NC_012207.1 4366667 4367710 R chromosome partitioning protein complement(4366667..4367710) Mycobacterium bovis BCG str. Tokyo 172 7562517 YP_002647015.1 CDS gidB NC_012207.1 4367707 4368381 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(4367707..4368381) Mycobacterium bovis BCG str. Tokyo 172 7562516 YP_002647016.1 CDS JTY_3980 NC_012207.1 4368513 4369076 R Differs from Rv3920c by 1aa, W110R in Mycobacterium bovis, Mycobacterium bovis BCG Pasteur, and BCG Tokyo; hypothetical protein complement(4368513..4369076) Mycobacterium bovis BCG str. Tokyo 172 7561915 YP_002647017.1 CDS JTY_3981 NC_012207.1 4369148 4370248 R functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC complement(4369148..4370248) Mycobacterium bovis BCG str. Tokyo 172 7564317 YP_002647018.1 CDS JTY_3982 NC_012207.1 4370232 4370594 R hypothetical protein complement(4370232..4370594) Mycobacterium bovis BCG str. Tokyo 172 7564318 YP_002647019.1 CDS rnpA NC_012207.1 4370591 4370968 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(4370591..4370968) Mycobacterium bovis BCG str. Tokyo 172 7564319 YP_002647020.1 CDS rpmH NC_012207.1 4370965 4371108 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(4370965..4371108) Mycobacterium bovis BCG str. Tokyo 172 7561589 JTY_t0001 tRNA ileT NC_012207.1 10887 10960 D tRNA-Ile 10887..10960 Mycobacterium bovis BCG str. Tokyo 172 7560959 JTY_t0002 tRNA alaT NC_012207.1 11112 11184 D tRNA-Ala 11112..11184 Mycobacterium bovis BCG str. Tokyo 172 7562774 JTY_t0003 tRNA leuT NC_012207.1 25625 25707 D tRNA-Leu 25625..25707 Mycobacterium bovis BCG str. Tokyo 172 7561835 JTY_t0004 tRNA glyU NC_012207.1 387463 387533 R tRNA-Gly complement(387463..387533) Mycobacterium bovis BCG str. Tokyo 172 7561943 JTY_t0005 tRNA tyrT NC_012207.1 659352 659432 D tRNA-Tyr 659352..659432 Mycobacterium bovis BCG str. Tokyo 172 7564106 JTY_t0006 tRNA thrT NC_012207.1 732731 732803 D tRNA-Thr 732731..732803 Mycobacterium bovis BCG str. Tokyo 172 7564155 JTY_t0007 tRNA metT NC_012207.1 732840 732913 D tRNA-Met 732840..732913 Mycobacterium bovis BCG str. Tokyo 172 7561854 JTY_t0008 tRNA trpT NC_012207.1 734761 734833 D tRNA-Trp 734761..734833 Mycobacterium bovis BCG str. Tokyo 172 7564158 JTY_t0009 tRNA thrV NC_012207.1 852785 852856 R tRNA-Thr complement(852785..852856) Mycobacterium bovis BCG str. Tokyo 172 7561083 JTY_t0010 tRNA lysT NC_012207.1 925941 926013 R tRNA-Lys complement(925941..926013) Mycobacterium bovis BCG str. Tokyo 172 7561965 JTY_t0011 tRNA gluT NC_012207.1 926137 926210 D tRNA-Glu 926137..926210 Mycobacterium bovis BCG str. Tokyo 172 7560543 JTY_t0012 tRNA aspT NC_012207.1 926248 926321 D tRNA-Asp 926248..926321 Mycobacterium bovis BCG str. Tokyo 172 7561950 JTY_t0013 tRNA pheU NC_012207.1 926351 926424 D tRNA-Phe 926351..926424 Mycobacterium bovis BCG str. Tokyo 172 7562046 JTY_t0014 tRNA argT NC_012207.1 1027513 1027585 R tRNA-Arg complement(1027513..1027585) Mycobacterium bovis BCG str. Tokyo 172 7562016 JTY_t0015 tRNA alaV NC_012207.1 1115661 1115733 D tRNA-Ala 1115661..1115733 Mycobacterium bovis BCG str. Tokyo 172 7563454 JTY_t0016 tRNA glnT NC_012207.1 1140222 1140293 R tRNA-Gln complement(1140222..1140293) Mycobacterium bovis BCG str. Tokyo 172 7561925 JTY_t0017 tRNA leuX NC_012207.1 1179543 1179616 D tRNA-Leu 1179543..1179616 Mycobacterium bovis BCG str. Tokyo 172 7563488 JTY_t0018 tRNA argV NC_012207.1 1445605 1445677 R tRNA-Arg complement(1445605..1445677) Mycobacterium bovis BCG str. Tokyo 172 7563624 JTY_t0019 tRNA leuW NC_012207.1 1512129 1512212 D tRNA-Leu 1512129..1512212 Mycobacterium bovis BCG str. Tokyo 172 7563647 JTY_t0020 tRNA leuV NC_012207.1 1806164 1806237 R tRNA-Leu complement(1806164..1806237) Mycobacterium bovis BCG str. Tokyo 172 7563147 JTY_t0021 tRNA proT NC_012207.1 1924731 1924804 D tRNA-Pro 1924731..1924804 Mycobacterium bovis BCG str. Tokyo 172 7560618 JTY_t0022 tRNA leuU NC_012207.1 2374770 2374855 D tRNA-Leu 2374770..2374855 Mycobacterium bovis BCG str. Tokyo 172 7564346 JTY_t0023 tRNA valV NC_012207.1 2482015 2482086 R tRNA-Val complement(2482015..2482086) Mycobacterium bovis BCG str. Tokyo 172 7564397 JTY_t0024 tRNA metV NC_012207.1 2551631 2551704 R tRNA-Met complement(2551631..2551704) Mycobacterium bovis BCG str. Tokyo 172 7562972 JTY_t0025 tRNA asnT NC_012207.1 2589276 2589348 R tRNA-Asn complement(2589276..2589348) Mycobacterium bovis BCG str. Tokyo 172 7561783 JTY_t0026 tRNA proU NC_012207.1 2723272 2723345 R tRNA-Pro complement(2723272..2723345) Mycobacterium bovis BCG str. Tokyo 172 7561859 JTY_t0027 tRNA glyV NC_012207.1 2723482 2723552 D tRNA-Gly 2723482..2723552 Mycobacterium bovis BCG str. Tokyo 172 7560829 JTY_t0028 tRNA argW NC_012207.1 2750756 2750829 D tRNA-Arg 2750756..2750829 Mycobacterium bovis BCG str. Tokyo 172 7562844 JTY_t0029 tRNA hisT NC_012207.1 2784423 2784495 D tRNA-His 2784423..2784495 Mycobacterium bovis BCG str. Tokyo 172 7562501 JTY_t0030 tRNA lysU NC_012207.1 2792063 2792135 D tRNA-Lys 2792063..2792135 Mycobacterium bovis BCG str. Tokyo 172 7560485 JTY_t0031 tRNA valT NC_012207.1 2926780 2926851 R tRNA-Val complement(2926780..2926851) Mycobacterium bovis BCG str. Tokyo 172 7561430 JTY_t0032 tRNA glyT NC_012207.1 2927036 2927108 D tRNA-Gly 2927036..2927108 Mycobacterium bovis BCG str. Tokyo 172 7561678 JTY_t0033 tRNA cysU NC_012207.1 2927138 2927208 D tRNA-Cys 2927138..2927208 Mycobacterium bovis BCG str. Tokyo 172 7563267 JTY_t0034 tRNA valU NC_012207.1 2927225 2927296 D tRNA-Val 2927225..2927296 Mycobacterium bovis BCG str. Tokyo 172 7561462 JTY_t0035 tRNA gluU NC_012207.1 3295684 3295756 R tRNA-Glu complement(3295684..3295756) Mycobacterium bovis BCG str. Tokyo 172 7562706 JTY_t0036 tRNA glnU NC_012207.1 3295796 3295867 R tRNA-Gln complement(3295796..3295867) Mycobacterium bovis BCG str. Tokyo 172 7561951 JTY_t0037 tRNA alaU NC_012207.1 3378976 3379048 R tRNA-Ala complement(3378976..3379048) Mycobacterium bovis BCG str. Tokyo 172 7562744 JTY_t0038 tRNA metU NC_012207.1 3504492 3504565 R tRNA-Met complement(3504492..3504565) Mycobacterium bovis BCG str. Tokyo 172 7561325 JTY_t0039 tRNA thrU NC_012207.1 4051637 4051709 R tRNA-Thr complement(4051637..4051709) Mycobacterium bovis BCG str. Tokyo 172 7563715 JTY_t0040 tRNA proY NC_012207.1 4096904 4096977 D tRNA-Pro 4096904..4096977 Mycobacterium bovis BCG str. Tokyo 172 7563743 JTY_t0041 tRNA serV NC_012207.1 4139106 4139191 D tRNA-Ser 4139106..4139191 Mycobacterium bovis BCG str. Tokyo 172 7562624 JTY_t0042 tRNA serX NC_012207.1 4168726 4168812 R tRNA-Ser complement(4168726..4168812) Mycobacterium bovis BCG str. Tokyo 172 7562647 JTY_t0043 tRNA argU NC_012207.1 4186460 4186532 R tRNA-Arg complement(4186460..4186532) Mycobacterium bovis BCG str. Tokyo 172 7562662 JTY_t0044 tRNA serT NC_012207.1 4186563 4186651 R tRNA-Ser complement(4186563..4186651) Mycobacterium bovis BCG str. Tokyo 172 7563993 JTY_t0045 tRNA serU NC_012207.1 4192177 4192263 R tRNA-Ser complement(4192177..4192263) Mycobacterium bovis BCG str. Tokyo 172 7562833 JTY_r0001 rRNA 16S_rRNA NC_012207.1 1471256 1472792 D 16S ribosomal RNA 1471256..1472792 Mycobacterium bovis BCG str. Tokyo 172 7563571 JTY_r0002 rRNA 23S_rRNA NC_012207.1 1473068 1476201 D 23S ribosomal RNA join(1473068..1474658,1474700..1476201) Mycobacterium bovis BCG str. Tokyo 172 7564323 JTY_r0003 rRNA 5S_rRNA NC_012207.1 1476309 1476423 D 5S ribosomal RNA 1476309..1476423 Mycobacterium bovis BCG str. Tokyo 172 7564324