-- dump date   	20140619_151647
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1048245000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1048245000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245000003	Walker A motif; other site
1048245000004	ATP binding site [chemical binding]; other site
1048245000005	Walker B motif; other site
1048245000006	arginine finger; other site
1048245000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1048245000008	DnaA box-binding interface [nucleotide binding]; other site
1048245000011	DNA polymerase III subunit beta; Validated; Region: PRK07761
1048245000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1048245000013	putative DNA binding surface [nucleotide binding]; other site
1048245000014	dimer interface [polypeptide binding]; other site
1048245000015	beta-clamp/clamp loader binding surface; other site
1048245000016	beta-clamp/translesion DNA polymerase binding surface; other site
1048245000017	recF protein; Region: recf; TIGR00611
1048245000018	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1048245000019	Walker A/P-loop; other site
1048245000020	ATP binding site [chemical binding]; other site
1048245000021	Q-loop/lid; other site
1048245000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1048245000023	ABC transporter signature motif; other site
1048245000024	Walker B; other site
1048245000025	D-loop; other site
1048245000026	H-loop/switch region; other site
1048245000030	hypothetical protein; Provisional; Region: PRK03195
1048245000031	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1048245000032	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1048245000033	Mg2+ binding site [ion binding]; other site
1048245000034	G-X-G motif; other site
1048245000035	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1048245000036	anchoring element; other site
1048245000037	dimer interface [polypeptide binding]; other site
1048245000038	ATP binding site [chemical binding]; other site
1048245000039	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1048245000040	active site
1048245000041	putative metal-binding site [ion binding]; other site
1048245000042	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1048245000044	DNA gyrase subunit A; Validated; Region: PRK05560
1048245000045	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1048245000046	CAP-like domain; other site
1048245000047	active site
1048245000048	primary dimer interface [polypeptide binding]; other site
1048245000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1048245000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1048245000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1048245000052	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1048245000053	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1048245000054	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1048245000056	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
1048245000057	Protein of unknown function (DUF2562); Region: DUF2562; pfam10814
1048245000058	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1048245000059	active site
1048245000060	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1048245000061	putative septation inhibitor protein; Reviewed; Region: PRK00159
1048245000062	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
1048245000063	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1048245000064	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1048245000065	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1048245000066	glutamine binding [chemical binding]; other site
1048245000067	catalytic triad [active]
1048245000070	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1048245000071	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1048245000072	active site
1048245000073	ATP binding site [chemical binding]; other site
1048245000074	substrate binding site [chemical binding]; other site
1048245000075	activation loop (A-loop); other site
1048245000076	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1048245000077	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1048245000078	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1048245000079	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1048245000080	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1048245000083	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1048245000084	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1048245000085	active site
1048245000086	ATP binding site [chemical binding]; other site
1048245000087	substrate binding site [chemical binding]; other site
1048245000088	activation loop (A-loop); other site
1048245000090	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1048245000091	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1048245000092	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1048245000093	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1048245000094	active site
1048245000095	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1048245000096	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1048245000097	phosphopeptide binding site; other site
1048245000098	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
1048245000099	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1048245000100	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1048245000101	phosphopeptide binding site; other site
1048245000102	Nitronate monooxygenase; Region: NMO; pfam03060
1048245000103	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1048245000104	FMN binding site [chemical binding]; other site
1048245000105	substrate binding site [chemical binding]; other site
1048245000106	putative catalytic residue [active]
1048245000107	Transcription factor WhiB; Region: Whib; pfam02467
1048245000108	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1048245000109	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1048245000110	non-specific DNA binding site [nucleotide binding]; other site
1048245000111	salt bridge; other site
1048245000112	sequence-specific DNA binding site [nucleotide binding]; other site
1048245000113	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1048245000114	NlpC/P60 family; Region: NLPC_P60; pfam00877
1048245000115	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
1048245000116	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
1048245000117	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
1048245000118	Protein of unknown function (DUF2694); Region: DUF2694; pfam10904
1048245000119	Protein of unknown function (DUF2710); Region: DUF2710; pfam10921
1048245000120	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1048245000121	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
1048245000122	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1048245000123	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1048245000124	catalytic residue [active]
1048245000126	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
1048245000127	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1048245000128	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1048245000129	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1048245000130	acyl-activating enzyme (AAE) consensus motif; other site
1048245000131	active site
1048245000132	TIGR03084 family protein; Region: TIGR03084
1048245000133	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1048245000134	Wyosine base formation; Region: Wyosine_form; pfam08608
1048245000135	H+ Antiporter protein; Region: 2A0121; TIGR00900
1048245000136	hypothetical protein; Validated; Region: PRK00228
1048245000137	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
1048245000138	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1048245000139	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1048245000140	active site
1048245000141	HIGH motif; other site
1048245000142	nucleotide binding site [chemical binding]; other site
1048245000143	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1048245000144	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1048245000145	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1048245000146	active site
1048245000147	KMSKS motif; other site
1048245000148	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1048245000149	tRNA binding surface [nucleotide binding]; other site
1048245000151	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1048245000152	MarR family; Region: MarR; pfam01047
1048245000153	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1048245000154	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1048245000155	DNA-binding site [nucleotide binding]; DNA binding site
1048245000156	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
1048245000157	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1048245000158	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245000159	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
1048245000160	inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450
1048245000161	Predicted transcriptional regulators [Transcription]; Region: COG1695
1048245000162	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1048245000163	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1048245000164	Transglycosylase; Region: Transgly; pfam00912
1048245000165	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1048245000166	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1048245000167	Predicted integral membrane protein [Function unknown]; Region: COG5650
1048245000168	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
1048245000169	conserved cys residue [active]
1048245000170	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1048245000172	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1048245000173	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1048245000174	dimer interface [polypeptide binding]; other site
1048245000175	ssDNA binding site [nucleotide binding]; other site
1048245000176	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1048245000177	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1048245000178	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1048245000179	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1048245000180	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1048245000182	replicative DNA helicase; Validated; Region: PRK07773
1048245000183	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1048245000184	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1048245000185	Walker A motif; other site
1048245000186	ATP binding site [chemical binding]; other site
1048245000187	Walker B motif; other site
1048245000188	DNA binding loops [nucleotide binding]
1048245000189	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1048245000190	protein-splicing catalytic site; other site
1048245000191	thioester formation/cholesterol transfer; other site
1048245000192	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1048245000193	protein-splicing catalytic site; other site
1048245000194	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1048245000196	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
1048245000197	ADP-ribose binding site [chemical binding]; other site
1048245000198	Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110
1048245000199	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
1048245000200	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1048245000201	FAD binding domain; Region: FAD_binding_4; pfam01565
1048245000202	Berberine and berberine like; Region: BBE; pfam08031
1048245000204	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1048245000205	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1048245000206	DNA binding residues [nucleotide binding]
1048245000207	hypothetical protein; Provisional; Region: PRK12438
1048245000208	hypothetical protein; Validated; Region: PRK00068
1048245000209	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
1048245000210	homotetrameric interface [polypeptide binding]; other site
1048245000211	putative active site [active]
1048245000212	metal binding site [ion binding]; metal-binding site
1048245000213	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
1048245000214	Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971
1048245000215	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245000216	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245000217	short chain dehydrogenase; Provisional; Region: PRK06197
1048245000218	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1048245000219	putative NAD(P) binding site [chemical binding]; other site
1048245000220	active site
1048245000221	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1048245000222	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1048245000223	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1048245000224	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1048245000225	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1048245000226	dimer interface [polypeptide binding]; other site
1048245000227	active site
1048245000228	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1048245000229	folate binding site [chemical binding]; other site
1048245000231	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
1048245000232	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1048245000233	putative NTP binding site [chemical binding]; other site
1048245000234	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1048245000235	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1048245000236	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1048245000237	Walker A/P-loop; other site
1048245000238	ATP binding site [chemical binding]; other site
1048245000239	Q-loop/lid; other site
1048245000240	ABC transporter signature motif; other site
1048245000241	Walker B; other site
1048245000242	D-loop; other site
1048245000243	H-loop/switch region; other site
1048245000244	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1048245000245	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1048245000246	ligand binding site [chemical binding]; other site
1048245000247	flexible hinge region; other site
1048245000251	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1048245000252	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1048245000253	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
1048245000254	active site
1048245000255	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1048245000256	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1048245000257	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245000258	homodimer interface [polypeptide binding]; other site
1048245000259	catalytic residue [active]
1048245000260	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245000261	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245000262	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245000263	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1048245000264	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1048245000265	dimerization interface [polypeptide binding]; other site
1048245000266	putative DNA binding site [nucleotide binding]; other site
1048245000267	putative Zn2+ binding site [ion binding]; other site
1048245000268	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
1048245000269	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1048245000270	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1048245000271	NADH dehydrogenase; Region: NADHdh; cl00469
1048245000272	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237
1048245000273	hydrogenase 4 subunit F; Validated; Region: PRK06458
1048245000274	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1048245000275	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
1048245000276	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
1048245000277	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
1048245000279	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1048245000280	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1048245000281	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1048245000282	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245000283	S-adenosylmethionine binding site [chemical binding]; other site
1048245000284	Predicted membrane protein [Function unknown]; Region: COG3305
1048245000285	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1048245000286	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1048245000287	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1048245000288	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1048245000289	metal-binding site [ion binding]
1048245000290	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1048245000291	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1048245000294	Predicted integral membrane protein [Function unknown]; Region: COG5660
1048245000295	Putative zinc-finger; Region: zf-HC2; pfam13490
1048245000296	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245000297	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245000298	active site
1048245000299	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245000300	PPE family; Region: PPE; pfam00823
1048245000301	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1048245000302	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
1048245000303	FcoT-like thioesterase domain; Region: FcoT; pfam10862
1048245000304	acyl-CoA synthetase; Validated; Region: PRK05857
1048245000305	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245000306	Adenylate forming domain, Class I; Region: AFD_class_I; cd04433
1048245000307	acyl-activating enzyme (AAE) consensus motif; other site
1048245000308	acyl-activating enzyme (AAE) consensus motif; other site
1048245000309	AMP binding site [chemical binding]; other site
1048245000310	active site
1048245000311	CoA binding site [chemical binding]; other site
1048245000313	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1048245000314	AMP-binding enzyme; Region: AMP-binding; pfam00501
1048245000315	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245000316	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245000317	acyl-activating enzyme (AAE) consensus motif; other site
1048245000318	acyl-activating enzyme (AAE) consensus motif; other site
1048245000319	active site
1048245000320	AMP binding site [chemical binding]; other site
1048245000321	CoA binding site [chemical binding]; other site
1048245000322	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1048245000323	Condensation domain; Region: Condensation; pfam00668
1048245000324	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1048245000325	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1048245000326	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1048245000327	acyl-activating enzyme (AAE) consensus motif; other site
1048245000328	AMP binding site [chemical binding]; other site
1048245000329	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1048245000330	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
1048245000331	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1048245000332	putative NAD(P) binding site [chemical binding]; other site
1048245000333	active site
1048245000334	putative substrate binding site [chemical binding]; other site
1048245000339	Predicted membrane protein [Function unknown]; Region: COG3336
1048245000340	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1048245000341	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1048245000342	metal-binding site [ion binding]
1048245000343	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1048245000344	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1048245000347	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1048245000348	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1048245000349	ligand binding site [chemical binding]; other site
1048245000350	flexible hinge region; other site
1048245000351	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1048245000352	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1048245000353	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1048245000355	PE family; Region: PE; pfam00934
1048245000356	Rhomboid family; Region: Rhomboid; pfam01694
1048245000357	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1048245000358	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1048245000359	active site
1048245000360	catalytic triad [active]
1048245000361	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1048245000362	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1048245000363	NADP-binding site; other site
1048245000364	homotetramer interface [polypeptide binding]; other site
1048245000365	substrate binding site [chemical binding]; other site
1048245000366	homodimer interface [polypeptide binding]; other site
1048245000367	active site
1048245000369	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1048245000370	dimer interface [polypeptide binding]; other site
1048245000371	active site
1048245000372	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
1048245000373	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1048245000374	active site
1048245000375	motif I; other site
1048245000376	motif II; other site
1048245000377	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
1048245000379	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1048245000380	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1048245000381	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1048245000382	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1048245000383	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1048245000384	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1048245000385	dimerization interface [polypeptide binding]; other site
1048245000387	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
1048245000388	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1048245000389	PYR/PP interface [polypeptide binding]; other site
1048245000390	dimer interface [polypeptide binding]; other site
1048245000391	TPP binding site [chemical binding]; other site
1048245000392	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1048245000393	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
1048245000394	TPP-binding site; other site
1048245000395	dimer interface [polypeptide binding]; other site
1048245000396	acyl-CoA synthetase; Validated; Region: PRK05852
1048245000397	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245000398	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
1048245000399	acyl-activating enzyme (AAE) consensus motif; other site
1048245000400	acyl-activating enzyme (AAE) consensus motif; other site
1048245000401	putative AMP binding site [chemical binding]; other site
1048245000402	putative active site [active]
1048245000403	putative CoA binding site [chemical binding]; other site
1048245000405	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
1048245000406	elongation factor G; Reviewed; Region: PRK12740
1048245000407	G1 box; other site
1048245000408	putative GEF interaction site [polypeptide binding]; other site
1048245000409	GTP/Mg2+ binding site [chemical binding]; other site
1048245000410	Switch I region; other site
1048245000411	G2 box; other site
1048245000412	G3 box; other site
1048245000413	Switch II region; other site
1048245000414	G4 box; other site
1048245000415	G5 box; other site
1048245000416	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1048245000417	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1048245000418	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1048245000420	PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668
1048245000421	PE family; Region: PE; pfam00934
1048245000422	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1048245000423	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1048245000424	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1048245000426	trehalose synthase; Region: treS_nterm; TIGR02456
1048245000427	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
1048245000428	active site
1048245000429	catalytic site [active]
1048245000430	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
1048245000431	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
1048245000432	Predicted membrane protein [Function unknown]; Region: COG3619
1048245000433	Predicted esterase [General function prediction only]; Region: COG0627
1048245000434	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1048245000435	putative active site [active]
1048245000436	putative catalytic site [active]
1048245000437	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245000438	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245000439	active site
1048245000440	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
1048245000441	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1048245000443	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1048245000444	Coenzyme A binding pocket [chemical binding]; other site
1048245000445	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245000446	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1048245000447	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245000448	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245000449	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245000450	Cytochrome P450; Region: p450; cl12078
1048245000453	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1048245000454	SnoaL-like domain; Region: SnoaL_2; pfam12680
1048245000455	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
1048245000456	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245000457	NAD(P) binding site [chemical binding]; other site
1048245000458	active site
1048245000459	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
1048245000460	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1048245000461	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1048245000462	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1048245000463	minor groove reading motif; other site
1048245000464	helix-hairpin-helix signature motif; other site
1048245000465	active site
1048245000466	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1048245000467	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1048245000468	Cl- selectivity filter; other site
1048245000469	Cl- binding residues [ion binding]; other site
1048245000470	pore gating glutamate residue; other site
1048245000471	dimer interface [polypeptide binding]; other site
1048245000472	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245000473	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245000474	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1048245000475	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1048245000476	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1048245000477	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1048245000478	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1048245000479	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
1048245000480	NAD(P) binding site [chemical binding]; other site
1048245000481	catalytic residues [active]
1048245000484	short chain dehydrogenase; Provisional; Region: PRK07791
1048245000485	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
1048245000486	NAD binding site [chemical binding]; other site
1048245000487	homodimer interface [polypeptide binding]; other site
1048245000488	active site
1048245000490	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1048245000491	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1048245000492	NAD(P) binding site [chemical binding]; other site
1048245000494	Integrase core domain; Region: rve; pfam00665
1048245000495	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1048245000496	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1048245000497	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245000498	Walker A motif; other site
1048245000499	ATP binding site [chemical binding]; other site
1048245000500	Walker B motif; other site
1048245000501	PE family; Region: PE; pfam00934
1048245000502	PE-PPE domain; Region: PE-PPE; pfam08237
1048245000503	PE family; Region: PE; pfam00934
1048245000504	PE-PPE domain; Region: PE-PPE; pfam08237
1048245000505	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
1048245000506	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
1048245000507	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1048245000508	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245000509	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
1048245000510	FAD binding site [chemical binding]; other site
1048245000511	substrate binding site [chemical binding]; other site
1048245000512	catalytic base [active]
1048245000513	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1048245000514	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1048245000515	ligand binding site [chemical binding]; other site
1048245000516	homodimer interface [polypeptide binding]; other site
1048245000517	NAD(P) binding site [chemical binding]; other site
1048245000518	trimer interface B [polypeptide binding]; other site
1048245000519	trimer interface A [polypeptide binding]; other site
1048245000520	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1048245000521	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1048245000522	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
1048245000523	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1048245000524	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245000525	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245000526	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
1048245000527	PE family; Region: PE; pfam00934
1048245000528	PE-PPE domain; Region: PE-PPE; pfam08237
1048245000529	PE family; Region: PE; pfam00934
1048245000530	PE-PPE domain; Region: PE-PPE; pfam08237
1048245000531	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1048245000532	FAD binding domain; Region: FAD_binding_4; pfam01565
1048245000533	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1048245000534	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1048245000535	NAD(P) binding site [chemical binding]; other site
1048245000537	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1048245000538	active site
1048245000539	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1048245000540	putative hydrophobic ligand binding site [chemical binding]; other site
1048245000541	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1048245000542	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1048245000543	DNA-binding site [nucleotide binding]; DNA binding site
1048245000544	FCD domain; Region: FCD; pfam07729
1048245000545	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
1048245000546	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245000547	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1048245000548	acyl-activating enzyme (AAE) consensus motif; other site
1048245000549	acyl-activating enzyme (AAE) consensus motif; other site
1048245000550	putative AMP binding site [chemical binding]; other site
1048245000551	putative active site [active]
1048245000552	putative CoA binding site [chemical binding]; other site
1048245000554	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1048245000555	Permease; Region: Permease; pfam02405
1048245000556	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1048245000557	Permease; Region: Permease; pfam02405
1048245000558	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245000559	mce related protein; Region: MCE; pfam02470
1048245000560	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1048245000561	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245000562	mce related protein; Region: MCE; pfam02470
1048245000563	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1048245000564	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245000565	mce related protein; Region: MCE; pfam02470
1048245000566	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245000567	mce related protein; Region: MCE; pfam02470
1048245000568	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245000569	mce related protein; Region: MCE; pfam02470
1048245000571	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245000572	mce related protein; Region: MCE; pfam02470
1048245000573	RDD family; Region: RDD; pfam06271
1048245000574	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1048245000575	Predicted membrane protein [Function unknown]; Region: COG1511
1048245000576	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1048245000577	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1048245000578	Pirin-related protein [General function prediction only]; Region: COG1741
1048245000579	Pirin; Region: Pirin; pfam02678
1048245000580	RNA polymerase factor sigma-70; Validated; Region: PRK08241
1048245000581	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1048245000582	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1048245000583	DNA binding residues [nucleotide binding]
1048245000584	SnoaL-like domain; Region: SnoaL_2; pfam12680
1048245000586	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1048245000587	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1048245000588	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
1048245000589	putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185
1048245000591	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1048245000592	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1048245000593	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1048245000594	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1048245000595	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1048245000596	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245000597	S-adenosylmethionine binding site [chemical binding]; other site
1048245000598	SPW repeat; Region: SPW; pfam03779
1048245000599	SPW repeat; Region: SPW; pfam03779
1048245000600	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1048245000601	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1048245000603	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1048245000604	putative homodimer interface [polypeptide binding]; other site
1048245000605	putative homotetramer interface [polypeptide binding]; other site
1048245000606	putative allosteric switch controlling residues; other site
1048245000607	putative metal binding site [ion binding]; other site
1048245000608	putative homodimer-homodimer interface [polypeptide binding]; other site
1048245000609	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1048245000610	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245000611	putative substrate translocation pore; other site
1048245000612	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1048245000613	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1048245000614	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1048245000615	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1048245000616	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1048245000617	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1048245000618	Walker A/P-loop; other site
1048245000619	ATP binding site [chemical binding]; other site
1048245000620	Q-loop/lid; other site
1048245000621	ABC transporter signature motif; other site
1048245000622	Walker B; other site
1048245000623	D-loop; other site
1048245000624	H-loop/switch region; other site
1048245000625	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1048245000626	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1048245000627	Walker A/P-loop; other site
1048245000628	ATP binding site [chemical binding]; other site
1048245000629	Q-loop/lid; other site
1048245000630	ABC transporter signature motif; other site
1048245000631	Walker B; other site
1048245000632	D-loop; other site
1048245000633	H-loop/switch region; other site
1048245000637	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1048245000638	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1048245000639	dimerization interface [polypeptide binding]; other site
1048245000640	DNA binding residues [nucleotide binding]
1048245000641	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245000642	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245000643	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1048245000644	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1048245000645	molybdopterin cofactor binding site; other site
1048245000646	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1048245000647	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
1048245000648	putative molybdopterin cofactor binding site; other site
1048245000649	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1048245000650	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1048245000651	active site
1048245000652	Zn binding site [ion binding]; other site
1048245000654	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1048245000655	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
1048245000656	Predicted integral membrane protein [Function unknown]; Region: COG0392
1048245000657	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1048245000658	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1048245000659	MMPL family; Region: MMPL; pfam03176
1048245000660	MMPL family; Region: MMPL; pfam03176
1048245000661	LabA_like proteins; Region: LabA_like; cd06167
1048245000662	putative metal binding site [ion binding]; other site
1048245000663	Putative methyltransferase; Region: Methyltransf_4; pfam02390
1048245000664	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
1048245000665	active site
1048245000666	substrate-binding site [chemical binding]; other site
1048245000667	metal-binding site [ion binding]
1048245000668	GTP binding site [chemical binding]; other site
1048245000670	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
1048245000671	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1048245000672	active site
1048245000673	nucleotide binding site [chemical binding]; other site
1048245000674	HIGH motif; other site
1048245000675	KMSKS motif; other site
1048245000676	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
1048245000678	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
1048245000679	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
1048245000680	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1048245000681	FeS/SAM binding site; other site
1048245000682	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
1048245000683	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245000684	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1048245000685	acyl-activating enzyme (AAE) consensus motif; other site
1048245000686	acyl-activating enzyme (AAE) consensus motif; other site
1048245000687	putative AMP binding site [chemical binding]; other site
1048245000688	putative active site [active]
1048245000689	putative CoA binding site [chemical binding]; other site
1048245000691	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245000692	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245000693	active site
1048245000694	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1048245000695	putative active site [active]
1048245000696	putative catalytic site [active]
1048245000697	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1048245000698	active site 2 [active]
1048245000699	active site 1 [active]
1048245000700	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1048245000701	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1048245000702	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1048245000703	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321
1048245000704	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1048245000705	Moco binding site; other site
1048245000706	metal coordination site [ion binding]; other site
1048245000707	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1048245000708	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1048245000710	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1048245000711	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1048245000712	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
1048245000713	enoyl-CoA hydratase; Provisional; Region: PRK08252
1048245000714	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245000715	substrate binding site [chemical binding]; other site
1048245000716	oxyanion hole (OAH) forming residues; other site
1048245000717	trimer interface [polypeptide binding]; other site
1048245000718	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
1048245000719	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1048245000720	NAD binding site [chemical binding]; other site
1048245000721	catalytic residues [active]
1048245000724	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245000725	S-adenosylmethionine binding site [chemical binding]; other site
1048245000726	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1048245000727	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1048245000728	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
1048245000729	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1048245000730	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1048245000731	putative active site [active]
1048245000733	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
1048245000734	active site
1048245000735	substrate binding pocket [chemical binding]; other site
1048245000736	homodimer interaction site [polypeptide binding]; other site
1048245000737	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245000738	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1048245000739	active site
1048245000740	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245000741	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245000743	Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911
1048245000744	active site
1048245000745	diiron metal binding site [ion binding]; other site
1048245000746	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1048245000747	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1048245000748	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1048245000749	NAD(P) binding site [chemical binding]; other site
1048245000750	catalytic residues [active]
1048245000752	Lipase maturation factor; Region: LMF1; pfam06762
1048245000753	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
1048245000754	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
1048245000755	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1048245000756	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1048245000758	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245000759	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245000760	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1048245000761	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1048245000762	MaoC like domain; Region: MaoC_dehydratas; pfam01575
1048245000763	active site 2 [active]
1048245000764	active site 1 [active]
1048245000765	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
1048245000766	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245000767	NAD(P) binding site [chemical binding]; other site
1048245000768	active site
1048245000770	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
1048245000771	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1048245000772	dimer interface [polypeptide binding]; other site
1048245000773	active site
1048245000775	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1048245000776	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1048245000777	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
1048245000778	FAD binding site [chemical binding]; other site
1048245000779	substrate binding site [chemical binding]; other site
1048245000780	catalytic residues [active]
1048245000781	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1048245000782	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1048245000783	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
1048245000784	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1048245000785	catalytic loop [active]
1048245000786	iron binding site [ion binding]; other site
1048245000788	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
1048245000789	L-aspartate oxidase; Provisional; Region: PRK06175
1048245000790	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1048245000793	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1048245000794	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1048245000795	putative dimer interface [polypeptide binding]; other site
1048245000796	nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374
1048245000797	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1048245000798	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1048245000799	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1048245000801	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1048245000802	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1048245000803	homotrimer interface [polypeptide binding]; other site
1048245000804	Walker A motif; other site
1048245000805	GTP binding site [chemical binding]; other site
1048245000806	Walker B motif; other site
1048245000808	cobyric acid synthase; Provisional; Region: PRK00784
1048245000809	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1048245000810	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1048245000811	catalytic triad [active]
1048245000812	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245000813	PPE family; Region: PPE; pfam00823
1048245000814	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1048245000815	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1048245000816	putative active site [active]
1048245000817	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1048245000818	putative active site [active]
1048245000819	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
1048245000820	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1048245000821	active site
1048245000822	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
1048245000823	DNA binding site [nucleotide binding]
1048245000824	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1048245000825	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1048245000826	Coenzyme A binding pocket [chemical binding]; other site
1048245000827	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
1048245000828	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1048245000829	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1048245000830	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1048245000831	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1048245000832	intersubunit interface [polypeptide binding]; other site
1048245000834	5-oxoprolinase; Region: PLN02666
1048245000835	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1048245000836	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1048245000837	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1048245000838	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1048245000839	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
1048245000840	nucleotide binding site [chemical binding]; other site
1048245000841	acyl-CoA synthetase; Validated; Region: PRK07788
1048245000842	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245000843	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245000844	active site
1048245000845	CoA binding site [chemical binding]; other site
1048245000846	AMP binding site [chemical binding]; other site
1048245000848	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245000849	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245000850	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
1048245000851	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245000852	FAD binding site [chemical binding]; other site
1048245000853	substrate binding site [chemical binding]; other site
1048245000854	catalytic base [active]
1048245000855	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1048245000856	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245000857	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245000858	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1048245000859	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1048245000860	Zn binding site [ion binding]; other site
1048245000862	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
1048245000863	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1048245000864	putative active site [active]
1048245000865	PE family; Region: PE; pfam00934
1048245000867	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1048245000868	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1048245000869	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245000870	PPE family; Region: PPE; pfam00823
1048245000871	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245000872	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1048245000873	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1048245000874	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
1048245000875	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245000876	Walker A motif; other site
1048245000877	ATP binding site [chemical binding]; other site
1048245000878	Walker B motif; other site
1048245000879	arginine finger; other site
1048245000881	Protein of unknown function (DUF690); Region: DUF690; pfam05108
1048245000883	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1048245000884	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1048245000885	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1048245000886	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1048245000887	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1048245000891	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245000892	PPE family; Region: PPE; pfam00823
1048245000893	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1048245000894	EspG family; Region: ESX-1_EspG; pfam14011
1048245000895	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1048245000896	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1048245000897	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1048245000898	active site
1048245000899	catalytic residues [active]
1048245000901	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
1048245000902	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1048245000903	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
1048245000904	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
1048245000905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245000906	S-adenosylmethionine binding site [chemical binding]; other site
1048245000907	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424
1048245000908	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1048245000909	Sulfatase; Region: Sulfatase; cl17466
1048245000911	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245000912	PPE family; Region: PPE; pfam00823
1048245000913	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245000914	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245000915	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245000916	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245000917	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245000918	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245000919	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245000920	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245000921	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245000922	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245000923	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245000924	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
1048245000925	putative FMN binding site [chemical binding]; other site
1048245000926	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1048245000927	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1048245000928	active site
1048245000929	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
1048245000930	SnoaL-like domain; Region: SnoaL_4; pfam13577
1048245000931	SnoaL-like domain; Region: SnoaL_3; pfam13474
1048245000932	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
1048245000933	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1048245000934	nucleotide binding site [chemical binding]; other site
1048245000935	Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326
1048245000936	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
1048245000937	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
1048245000938	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
1048245000939	active site
1048245000940	catalytic residues [active]
1048245000942	Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829
1048245000943	Muconolactone delta-isomerase; Region: MIase; cl01992
1048245000944	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
1048245000945	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1048245000946	putative active site [active]
1048245000947	catalytic site [active]
1048245000948	putative metal binding site [ion binding]; other site
1048245000949	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
1048245000950	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1048245000951	putative substrate binding pocket [chemical binding]; other site
1048245000952	AC domain interface; other site
1048245000953	catalytic triad [active]
1048245000954	AB domain interface; other site
1048245000955	interchain disulfide; other site
1048245000956	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1048245000957	trimer interface [polypeptide binding]; other site
1048245000958	active site
1048245000960	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1048245000961	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1048245000962	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1048245000963	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1048245000965	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
1048245000966	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1048245000967	dimerization interface [polypeptide binding]; other site
1048245000968	putative DNA binding site [nucleotide binding]; other site
1048245000969	putative Zn2+ binding site [ion binding]; other site
1048245000970	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1048245000971	active site residue [active]
1048245000972	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245000973	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245000974	Cytochrome P450; Region: p450; cl12078
1048245000976	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
1048245000977	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245000978	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1048245000979	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1048245000980	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245000981	S-adenosylmethionine binding site [chemical binding]; other site
1048245000982	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245000983	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245000984	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1048245000985	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1048245000986	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1048245000987	SnoaL-like domain; Region: SnoaL_2; pfam12680
1048245000988	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1048245000989	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1048245000990	substrate binding site; other site
1048245000991	tetramer interface; other site
1048245000992	PE family; Region: PE; pfam00934
1048245000993	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245000994	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245000995	active site
1048245000996	aminotransferase AlaT; Validated; Region: PRK09265
1048245000997	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1048245000998	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245000999	homodimer interface [polypeptide binding]; other site
1048245001000	catalytic residue [active]
1048245001001	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1048245001002	4Fe-4S binding domain; Region: Fer4; pfam00037
1048245001003	Cysteine-rich domain; Region: CCG; pfam02754
1048245001004	Cysteine-rich domain; Region: CCG; pfam02754
1048245001008	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1048245001009	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1048245001010	DNA binding residues [nucleotide binding]
1048245001011	dimerization interface [polypeptide binding]; other site
1048245001013	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
1048245001014	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1048245001015	G1 box; other site
1048245001016	GTP/Mg2+ binding site [chemical binding]; other site
1048245001017	G2 box; other site
1048245001018	Switch I region; other site
1048245001019	G3 box; other site
1048245001020	Switch II region; other site
1048245001021	G4 box; other site
1048245001022	G5 box; other site
1048245001023	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
1048245001024	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1048245001025	G1 box; other site
1048245001026	GTP/Mg2+ binding site [chemical binding]; other site
1048245001027	G2 box; other site
1048245001028	Switch I region; other site
1048245001029	G3 box; other site
1048245001030	Switch II region; other site
1048245001033	Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068
1048245001034	active site
1048245001035	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1048245001036	TIGR04255 family protein; Region: sporadTIGR04255
1048245001037	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1048245001038	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1048245001039	nucleotide binding site [chemical binding]; other site
1048245001040	NEF interaction site [polypeptide binding]; other site
1048245001041	SBD interface [polypeptide binding]; other site
1048245001042	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
1048245001043	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1048245001044	dimer interface [polypeptide binding]; other site
1048245001045	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1048245001047	chaperone protein DnaJ; Provisional; Region: PRK14279
1048245001048	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1048245001049	HSP70 interaction site [polypeptide binding]; other site
1048245001050	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1048245001051	Zn binding sites [ion binding]; other site
1048245001052	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1048245001053	dimer interface [polypeptide binding]; other site
1048245001056	Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279
1048245001057	DNA binding residues [nucleotide binding]
1048245001058	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1048245001059	putative dimer interface [polypeptide binding]; other site
1048245001060	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245001061	PPE family; Region: PPE; pfam00823
1048245001062	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245001063	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245001064	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245001065	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245001066	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245001067	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245001068	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245001069	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1048245001070	CoenzymeA binding site [chemical binding]; other site
1048245001071	subunit interaction site [polypeptide binding]; other site
1048245001072	PHB binding site; other site
1048245001073	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1048245001074	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1048245001075	GDP-binding site [chemical binding]; other site
1048245001076	ACT binding site; other site
1048245001077	IMP binding site; other site
1048245001078	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1048245001079	Peptidase family M50; Region: Peptidase_M50; pfam02163
1048245001080	active site
1048245001081	putative substrate binding region [chemical binding]; other site
1048245001083	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
1048245001084	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1048245001085	MgtE intracellular N domain; Region: MgtE_N; pfam03448
1048245001086	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1048245001087	Divalent cation transporter; Region: MgtE; pfam01769
1048245001088	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1048245001089	fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520
1048245001090	active site
1048245001091	intersubunit interface [polypeptide binding]; other site
1048245001092	zinc binding site [ion binding]; other site
1048245001093	Na+ binding site [ion binding]; other site
1048245001094	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1048245001095	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1048245001096	Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833
1048245001097	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
1048245001098	AAA domain; Region: AAA_33; pfam13671
1048245001101	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
1048245001102	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
1048245001103	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
1048245001104	metal ion-dependent adhesion site (MIDAS); other site
1048245001106	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
1048245001107	putative hydrophobic ligand binding site [chemical binding]; other site
1048245001108	MoxR-like ATPases [General function prediction only]; Region: COG0714
1048245001110	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1048245001111	Ligand binding site; other site
1048245001112	metal-binding site
1048245001113	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1048245001114	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1048245001115	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1048245001116	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
1048245001117	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
1048245001118	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1048245001119	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1048245001120	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1048245001121	catalytic loop [active]
1048245001122	iron binding site [ion binding]; other site
1048245001123	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1048245001124	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1048245001125	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1048245001126	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1048245001127	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1048245001128	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1048245001129	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1048245001130	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1048245001131	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1048245001132	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1048245001133	dimerization interface [polypeptide binding]; other site
1048245001135	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1048245001136	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1048245001137	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1048245001138	Uncharacterized conserved protein [Function unknown]; Region: COG3360
1048245001139	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1048245001140	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1048245001141	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1048245001142	active site
1048245001144	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1048245001145	Clp amino terminal domain; Region: Clp_N; pfam02861
1048245001146	Clp amino terminal domain; Region: Clp_N; pfam02861
1048245001147	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245001148	Walker A motif; other site
1048245001149	ATP binding site [chemical binding]; other site
1048245001150	Walker B motif; other site
1048245001151	arginine finger; other site
1048245001152	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245001153	Walker A motif; other site
1048245001154	ATP binding site [chemical binding]; other site
1048245001155	Walker B motif; other site
1048245001156	arginine finger; other site
1048245001157	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1048245001162	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1048245001163	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1048245001164	heme-binding site [chemical binding]; other site
1048245001165	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
1048245001166	FAD binding pocket [chemical binding]; other site
1048245001167	FAD binding motif [chemical binding]; other site
1048245001168	phosphate binding motif [ion binding]; other site
1048245001169	beta-alpha-beta structure motif; other site
1048245001170	NAD binding pocket [chemical binding]; other site
1048245001171	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1048245001172	cyclase homology domain; Region: CHD; cd07302
1048245001173	nucleotidyl binding site; other site
1048245001174	metal binding site [ion binding]; metal-binding site
1048245001175	dimer interface [polypeptide binding]; other site
1048245001176	Predicted ATPase [General function prediction only]; Region: COG3903
1048245001177	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1048245001178	Walker A motif; other site
1048245001179	ATP binding site [chemical binding]; other site
1048245001180	Walker B motif; other site
1048245001181	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1048245001182	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1048245001183	DNA binding residues [nucleotide binding]
1048245001186	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245001187	PPE family; Region: PPE; pfam00823
1048245001188	Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027
1048245001189	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1048245001190	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1048245001191	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
1048245001192	active site residue [active]
1048245001193	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
1048245001194	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1048245001195	homodimer interface [polypeptide binding]; other site
1048245001196	substrate-cofactor binding pocket; other site
1048245001197	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245001198	catalytic residue [active]
1048245001199	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1048245001200	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1048245001201	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1048245001202	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1048245001203	Beta-lactamase; Region: Beta-lactamase; pfam00144
1048245001204	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245001205	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245001206	active site
1048245001207	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
1048245001208	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1048245001209	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1048245001210	acyl-CoA synthetase; Validated; Region: PRK05850
1048245001211	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1048245001212	acyl-activating enzyme (AAE) consensus motif; other site
1048245001213	active site
1048245001214	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
1048245001215	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245001216	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1048245001217	active site
1048245001218	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1048245001219	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1048245001220	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245001221	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245001222	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1048245001223	active site
1048245001224	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1048245001225	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1048245001226	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245001227	Thioesterase; Region: PKS_TE; smart00824
1048245001232	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
1048245001233	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1048245001234	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1048245001235	phosphate acetyltransferase; Reviewed; Region: PRK05632
1048245001236	DRTGG domain; Region: DRTGG; pfam07085
1048245001237	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1048245001238	propionate/acetate kinase; Provisional; Region: PRK12379
1048245001239	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1048245001242	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1048245001243	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1048245001244	active site
1048245001245	ATP binding site [chemical binding]; other site
1048245001246	substrate binding site [chemical binding]; other site
1048245001247	activation loop (A-loop); other site
1048245001249	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1048245001250	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1048245001251	substrate binding pocket [chemical binding]; other site
1048245001252	membrane-bound complex binding site; other site
1048245001253	hinge residues; other site
1048245001256	NUDIX domain; Region: NUDIX; pfam00293
1048245001257	nudix motif; other site
1048245001258	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1048245001259	thiamine phosphate binding site [chemical binding]; other site
1048245001260	active site
1048245001261	pyrophosphate binding site [ion binding]; other site
1048245001262	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1048245001263	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1048245001264	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1048245001265	thiS-thiF/thiG interaction site; other site
1048245001266	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1048245001267	ThiS interaction site; other site
1048245001268	putative active site [active]
1048245001269	tetramer interface [polypeptide binding]; other site
1048245001270	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
1048245001271	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1048245001272	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
1048245001273	PA/protease or protease-like domain interface [polypeptide binding]; other site
1048245001274	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
1048245001275	active site
1048245001276	metal binding site [ion binding]; metal-binding site
1048245001278	Predicted metalloprotease [General function prediction only]; Region: COG2321
1048245001279	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1048245001280	Zn binding site [ion binding]; other site
1048245001283	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1048245001284	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1048245001285	dimer interface [polypeptide binding]; other site
1048245001286	substrate binding site [chemical binding]; other site
1048245001287	ATP binding site [chemical binding]; other site
1048245001288	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1048245001289	ThiC-associated domain; Region: ThiC-associated; pfam13667
1048245001290	ThiC family; Region: ThiC; pfam01964
1048245001291	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1048245001292	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
1048245001293	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1048245001294	motif II; other site
1048245001295	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1048245001296	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1048245001297	putative catalytic site [active]
1048245001298	putative phosphate binding site [ion binding]; other site
1048245001299	active site
1048245001300	metal binding site A [ion binding]; metal-binding site
1048245001301	DNA binding site [nucleotide binding]
1048245001302	putative AP binding site [nucleotide binding]; other site
1048245001303	putative metal binding site B [ion binding]; other site
1048245001304	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1048245001305	active site
1048245001306	catalytic residues [active]
1048245001307	metal binding site [ion binding]; metal-binding site
1048245001308	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
1048245001309	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1048245001310	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1048245001311	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1048245001312	E-class dimer interface [polypeptide binding]; other site
1048245001313	P-class dimer interface [polypeptide binding]; other site
1048245001314	active site
1048245001315	Cu2+ binding site [ion binding]; other site
1048245001316	Zn2+ binding site [ion binding]; other site
1048245001318	carboxylate-amine ligase; Provisional; Region: PRK13517
1048245001319	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
1048245001320	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
1048245001321	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
1048245001322	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
1048245001323	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245001324	Walker A motif; other site
1048245001325	ATP binding site [chemical binding]; other site
1048245001326	Walker B motif; other site
1048245001327	arginine finger; other site
1048245001328	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245001329	Walker A motif; other site
1048245001330	ATP binding site [chemical binding]; other site
1048245001331	Walker B motif; other site
1048245001332	arginine finger; other site
1048245001335	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1048245001336	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1048245001338	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
1048245001339	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1048245001340	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1048245001341	dimer interface [polypeptide binding]; other site
1048245001342	putative functional site; other site
1048245001343	putative MPT binding site; other site
1048245001344	short chain dehydrogenase; Provisional; Region: PRK06197
1048245001345	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1048245001346	putative NAD(P) binding site [chemical binding]; other site
1048245001347	active site
1048245001348	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1048245001349	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1048245001350	ring oligomerisation interface [polypeptide binding]; other site
1048245001351	ATP/Mg binding site [chemical binding]; other site
1048245001352	stacking interactions; other site
1048245001353	hinge regions; other site
1048245001355	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1048245001356	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245001357	PPE family; Region: PPE; pfam00823
1048245001358	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1048245001359	DinB superfamily; Region: DinB_2; pfam12867
1048245001360	putative anti-sigmaE protein; Provisional; Region: PRK13920
1048245001361	Anti-sigma-K factor rskA; Region: RskA; pfam10099
1048245001362	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1048245001363	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1048245001364	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1048245001365	DNA binding residues [nucleotide binding]
1048245001366	Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752
1048245001367	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1048245001368	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245001369	S-adenosylmethionine binding site [chemical binding]; other site
1048245001370	Protein of unknown function (DUF1365); Region: DUF1365; cl17838
1048245001371	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
1048245001372	Transport protein; Region: actII; TIGR00833
1048245001374	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1048245001375	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245001376	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245001377	PPE family; Region: PPE; pfam00823
1048245001378	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245001379	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
1048245001380	enoyl-CoA hydratase; Provisional; Region: PRK12478
1048245001381	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245001382	substrate binding site [chemical binding]; other site
1048245001383	oxyanion hole (OAH) forming residues; other site
1048245001384	trimer interface [polypeptide binding]; other site
1048245001385	PemK-like protein; Region: PemK; pfam02452
1048245001386	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1048245001387	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1048245001388	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
1048245001389	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1048245001390	NAD(P) binding site [chemical binding]; other site
1048245001391	catalytic residues [active]
1048245001392	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564
1048245001393	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
1048245001394	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1048245001395	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1048245001396	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1048245001397	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1048245001398	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1048245001399	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1048245001400	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1048245001401	non-specific DNA binding site [nucleotide binding]; other site
1048245001402	salt bridge; other site
1048245001403	sequence-specific DNA binding site [nucleotide binding]; other site
1048245001404	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1048245001405	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1048245001406	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1048245001407	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
1048245001408	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1048245001409	active site
1048245001410	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1048245001411	active site 2 [active]
1048245001412	isocitrate lyase; Provisional; Region: PRK15063
1048245001413	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556
1048245001414	oligomerization interface [polypeptide binding]; other site
1048245001415	active site
1048245001416	metal binding site [ion binding]; metal-binding site
1048245001417	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
1048245001418	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1048245001419	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1048245001420	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1048245001421	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245001422	S-adenosylmethionine binding site [chemical binding]; other site
1048245001423	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1048245001424	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1048245001425	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245001426	S-adenosylmethionine binding site [chemical binding]; other site
1048245001427	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
1048245001428	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245001429	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245001430	Predicted membrane protein [Function unknown]; Region: COG2733
1048245001431	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1048245001432	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1048245001433	non-specific DNA binding site [nucleotide binding]; other site
1048245001434	salt bridge; other site
1048245001435	sequence-specific DNA binding site [nucleotide binding]; other site
1048245001436	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
1048245001438	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
1048245001439	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1048245001440	intersubunit interface [polypeptide binding]; other site
1048245001441	active site
1048245001442	catalytic residue [active]
1048245001443	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1048245001444	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1048245001445	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
1048245001446	putative active site [active]
1048245001447	catalytic triad [active]
1048245001448	putative dimer interface [polypeptide binding]; other site
1048245001449	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
1048245001450	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
1048245001451	FAD binding domain; Region: FAD_binding_4; pfam01565
1048245001452	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1048245001453	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1048245001454	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1048245001455	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
1048245001456	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1048245001457	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1048245001458	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245001459	NAD(P) binding site [chemical binding]; other site
1048245001460	active site
1048245001461	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1048245001462	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1048245001463	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1048245001464	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
1048245001465	putative ADP-binding pocket [chemical binding]; other site
1048245001467	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1048245001468	L-lysine exporter; Region: 2a75; TIGR00948
1048245001469	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1048245001470	catalytic core [active]
1048245001471	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
1048245001474	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1048245001475	dimer interface [polypeptide binding]; other site
1048245001476	phosphorylation site [posttranslational modification]
1048245001477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1048245001478	ATP binding site [chemical binding]; other site
1048245001479	Mg2+ binding site [ion binding]; other site
1048245001480	G-X-G motif; other site
1048245001481	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1048245001482	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1048245001483	active site
1048245001484	phosphorylation site [posttranslational modification]
1048245001485	intermolecular recognition site; other site
1048245001486	dimerization interface [polypeptide binding]; other site
1048245001487	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1048245001488	DNA binding site [nucleotide binding]
1048245001489	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
1048245001490	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1048245001493	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1048245001494	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1048245001495	DNA-binding site [nucleotide binding]; DNA binding site
1048245001496	FCD domain; Region: FCD; pfam07729
1048245001498	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1048245001499	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1048245001500	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1048245001501	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1048245001502	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1048245001503	Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046
1048245001504	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1048245001505	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1048245001506	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1048245001507	DNA binding domain, excisionase family; Region: excise; TIGR01764
1048245001508	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1048245001509	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
1048245001510	putative NAD(P) binding site [chemical binding]; other site
1048245001511	active site
1048245001512	putative substrate binding site [chemical binding]; other site
1048245001513	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1048245001514	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
1048245001515	putative acyl-acceptor binding pocket; other site
1048245001516	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1048245001517	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1048245001518	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245001519	S-adenosylmethionine binding site [chemical binding]; other site
1048245001520	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1048245001521	active site
1048245001522	catalytic site [active]
1048245001523	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1048245001524	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1048245001525	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1048245001526	glutamyl-tRNA reductase; Region: hemA; TIGR01035
1048245001527	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1048245001528	tRNA; other site
1048245001529	putative tRNA binding site [nucleotide binding]; other site
1048245001530	putative NADP binding site [chemical binding]; other site
1048245001531	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1048245001533	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1048245001534	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
1048245001535	domain interfaces; other site
1048245001536	active site
1048245001537	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
1048245001538	active site
1048245001539	homodimer interface [polypeptide binding]; other site
1048245001540	SAM binding site [chemical binding]; other site
1048245001541	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1048245001542	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1048245001543	active site
1048245001544	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1048245001545	dimer interface [polypeptide binding]; other site
1048245001546	active site
1048245001547	Schiff base residues; other site
1048245001549	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245001550	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245001551	active site
1048245001552	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1048245001553	anti sigma factor interaction site; other site
1048245001554	regulatory phosphorylation site [posttranslational modification]; other site
1048245001555	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1048245001556	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1048245001557	active site
1048245001558	catalytic triad [active]
1048245001559	oxyanion hole [active]
1048245001560	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
1048245001562	PE family; Region: PE; pfam00934
1048245001564	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1048245001566	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1048245001567	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1048245001568	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1048245001569	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1048245001570	catalytic residue [active]
1048245001572	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1048245001573	catalytic core [active]
1048245001574	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1048245001575	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1048245001576	catalytic residues [active]
1048245001578	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1048245001579	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1048245001580	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
1048245001581	ResB-like family; Region: ResB; pfam05140
1048245001582	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1048245001583	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1048245001584	AAA domain; Region: AAA_31; pfam13614
1048245001585	P-loop; other site
1048245001586	Magnesium ion binding site [ion binding]; other site
1048245001587	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1048245001588	3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747
1048245001589	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1048245001590	dimer interface [polypeptide binding]; other site
1048245001591	active site
1048245001592	CoA binding pocket [chemical binding]; other site
1048245001593	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
1048245001594	UbiA prenyltransferase family; Region: UbiA; pfam01040
1048245001595	5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823
1048245001596	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1048245001597	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245001598	NAD(P) binding site [chemical binding]; other site
1048245001599	active site
1048245001600	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1048245001601	Ligand binding site; other site
1048245001602	Putative Catalytic site; other site
1048245001603	DXD motif; other site
1048245001605	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222
1048245001607	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
1048245001608	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245001609	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245001610	acyl-activating enzyme (AAE) consensus motif; other site
1048245001611	acyl-activating enzyme (AAE) consensus motif; other site
1048245001612	AMP binding site [chemical binding]; other site
1048245001613	active site
1048245001614	CoA binding site [chemical binding]; other site
1048245001616	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
1048245001617	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1048245001618	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1048245001619	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1048245001620	active site
1048245001621	short chain dehydrogenase; Provisional; Region: PRK05866
1048245001622	classical (c) SDRs; Region: SDR_c; cd05233
1048245001623	NAD(P) binding site [chemical binding]; other site
1048245001624	active site
1048245001625	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245001626	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1048245001627	substrate binding site [chemical binding]; other site
1048245001628	oxyanion hole (OAH) forming residues; other site
1048245001629	trimer interface [polypeptide binding]; other site
1048245001630	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
1048245001631	putative active site [active]
1048245001632	homotetrameric interface [polypeptide binding]; other site
1048245001633	metal binding site [ion binding]; metal-binding site
1048245001634	Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302
1048245001635	acyl-CoA synthetase; Validated; Region: PRK06188
1048245001636	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1048245001637	putative active site [active]
1048245001638	putative CoA binding site [chemical binding]; other site
1048245001639	putative AMP binding site [chemical binding]; other site
1048245001641	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1048245001642	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1048245001643	active site
1048245001644	O-succinylbenzoate synthase; Provisional; Region: PRK02901
1048245001645	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1048245001646	active site
1048245001647	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245001648	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1048245001649	TAP-like protein; Region: Abhydrolase_4; pfam08386
1048245001650	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1048245001651	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1048245001652	dimer interface [polypeptide binding]; other site
1048245001653	tetramer interface [polypeptide binding]; other site
1048245001654	PYR/PP interface [polypeptide binding]; other site
1048245001655	TPP binding site [chemical binding]; other site
1048245001656	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1048245001657	TPP-binding site; other site
1048245001658	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
1048245001659	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1048245001660	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1048245001661	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1048245001662	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245001663	S-adenosylmethionine binding site [chemical binding]; other site
1048245001664	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1048245001665	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1048245001666	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245001667	S-adenosylmethionine binding site [chemical binding]; other site
1048245001668	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1048245001669	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1048245001670	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1048245001671	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1048245001672	substrate binding pocket [chemical binding]; other site
1048245001673	chain length determination region; other site
1048245001674	substrate-Mg2+ binding site; other site
1048245001675	catalytic residues [active]
1048245001676	aspartate-rich region 1; other site
1048245001677	active site lid residues [active]
1048245001678	aspartate-rich region 2; other site
1048245001680	heat shock protein HtpX; Provisional; Region: PRK03072
1048245001682	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439
1048245001683	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1048245001684	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1048245001686	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1048245001687	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1048245001688	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1048245001689	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1048245001690	O-methyltransferase; Region: Methyltransf_2; pfam00891
1048245001691	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245001692	Cytochrome P450; Region: p450; cl12078
1048245001694	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
1048245001695	ATP cone domain; Region: ATP-cone; pfam03477
1048245001696	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
1048245001697	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
1048245001698	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
1048245001699	active site
1048245001700	dimer interface [polypeptide binding]; other site
1048245001701	effector binding site; other site
1048245001702	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1048245001703	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1048245001704	active site
1048245001705	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1048245001706	nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484
1048245001707	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1048245001708	active site
1048245001709	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
1048245001710	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1048245001711	putative active site [active]
1048245001712	putative metal binding site [ion binding]; other site
1048245001713	hypothetical protein; Provisional; Region: PRK07588
1048245001714	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1048245001715	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1048245001716	ABC1 family; Region: ABC1; pfam03109
1048245001717	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245001718	Cytochrome P450; Region: p450; cl12078
1048245001719	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
1048245001720	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245001721	Cytochrome P450; Region: p450; cl12078
1048245001722	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1048245001723	dimerization interface [polypeptide binding]; other site
1048245001724	putative DNA binding site [nucleotide binding]; other site
1048245001725	putative Zn2+ binding site [ion binding]; other site
1048245001726	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1048245001727	putative hydrophobic ligand binding site [chemical binding]; other site
1048245001728	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1048245001729	TIGR03086 family protein; Region: TIGR03086
1048245001730	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1048245001731	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1048245001732	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1048245001733	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
1048245001734	Uncharacterized conserved protein [Function unknown]; Region: COG1656
1048245001735	Protein of unknown function DUF82; Region: DUF82; pfam01927
1048245001736	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1048245001737	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1048245001738	putative active site [active]
1048245001739	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
1048245001741	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
1048245001742	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
1048245001744	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
1048245001745	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1048245001746	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1048245001747	DNA-binding site [nucleotide binding]; DNA binding site
1048245001748	FCD domain; Region: FCD; pfam07729
1048245001750	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1048245001751	Permease; Region: Permease; pfam02405
1048245001752	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1048245001753	Permease; Region: Permease; pfam02405
1048245001754	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245001755	mce related protein; Region: MCE; pfam02470
1048245001756	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1048245001757	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1048245001758	mce related protein; Region: MCE; pfam02470
1048245001759	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1048245001760	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245001761	mce related protein; Region: MCE; pfam02470
1048245001763	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245001764	mce related protein; Region: MCE; pfam02470
1048245001765	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1048245001766	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245001767	mce related protein; Region: MCE; pfam02470
1048245001769	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245001770	mce related protein; Region: MCE; pfam02470
1048245001771	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1048245001772	oligomeric interface; other site
1048245001773	putative active site [active]
1048245001774	homodimer interface [polypeptide binding]; other site
1048245001775	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1048245001776	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
1048245001777	AAA domain; Region: AAA_14; pfam13173
1048245001779	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1048245001780	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
1048245001781	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1048245001782	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1048245001783	ATP binding site [chemical binding]; other site
1048245001784	Mg2+ binding site [ion binding]; other site
1048245001785	G-X-G motif; other site
1048245001788	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
1048245001789	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
1048245001790	putative active site [active]
1048245001792	SEC-C motif; Region: SEC-C; pfam02810
1048245001793	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
1048245001794	putative active site [active]
1048245001795	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
1048245001796	dimer interface [polypeptide binding]; other site
1048245001797	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
1048245001798	active site
1048245001799	galactokinase; Provisional; Region: PRK00555
1048245001800	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1048245001804	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1048245001805	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1048245001806	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1048245001807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
1048245001808	FIST N domain; Region: FIST; pfam08495
1048245001809	FIST C domain; Region: FIST_C; pfam10442
1048245001810	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
1048245001811	AAA domain; Region: AAA_30; pfam13604
1048245001812	Family description; Region: UvrD_C_2; pfam13538
1048245001814	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
1048245001815	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1048245001817	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
1048245001818	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1048245001819	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1048245001820	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245001821	substrate binding site [chemical binding]; other site
1048245001822	oxyanion hole (OAH) forming residues; other site
1048245001823	trimer interface [polypeptide binding]; other site
1048245001824	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1048245001825	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1048245001826	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1048245001827	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1048245001828	active site
1048245001829	catalytic site [active]
1048245001830	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
1048245001831	active site
1048245001832	catalytic site [active]
1048245001833	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1048245001834	active site
1048245001835	catalytic site [active]
1048245001836	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1048245001838	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1048245001839	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1048245001840	putative homodimer interface [polypeptide binding]; other site
1048245001841	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1048245001842	heterodimer interface [polypeptide binding]; other site
1048245001843	homodimer interface [polypeptide binding]; other site
1048245001845	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1048245001846	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1048245001847	23S rRNA interface [nucleotide binding]; other site
1048245001848	L7/L12 interface [polypeptide binding]; other site
1048245001849	putative thiostrepton binding site; other site
1048245001850	L25 interface [polypeptide binding]; other site
1048245001852	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1048245001853	mRNA/rRNA interface [nucleotide binding]; other site
1048245001854	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1048245001855	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245001856	S-adenosylmethionine binding site [chemical binding]; other site
1048245001857	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1048245001858	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1048245001859	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245001860	S-adenosylmethionine binding site [chemical binding]; other site
1048245001861	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1048245001862	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1048245001863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245001864	S-adenosylmethionine binding site [chemical binding]; other site
1048245001865	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1048245001866	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1048245001867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245001868	S-adenosylmethionine binding site [chemical binding]; other site
1048245001869	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245001870	TAP-like protein; Region: Abhydrolase_4; pfam08386
1048245001871	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1048245001872	ABC1 family; Region: ABC1; cl17513
1048245001873	N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786
1048245001874	active site
1048245001875	catalytic site [active]
1048245001876	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
1048245001877	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
1048245001878	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
1048245001880	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1048245001881	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1048245001883	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1048245001884	23S rRNA interface [nucleotide binding]; other site
1048245001885	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1048245001886	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1048245001887	core dimer interface [polypeptide binding]; other site
1048245001888	peripheral dimer interface [polypeptide binding]; other site
1048245001889	L10 interface [polypeptide binding]; other site
1048245001890	L11 interface [polypeptide binding]; other site
1048245001891	putative EF-Tu interaction site [polypeptide binding]; other site
1048245001892	putative EF-G interaction site [polypeptide binding]; other site
1048245001893	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245001894	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245001895	WHG domain; Region: WHG; pfam13305
1048245001896	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
1048245001897	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
1048245001898	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1048245001899	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1048245001900	Walker A/P-loop; other site
1048245001901	ATP binding site [chemical binding]; other site
1048245001902	Q-loop/lid; other site
1048245001903	ABC transporter signature motif; other site
1048245001904	Walker B; other site
1048245001905	D-loop; other site
1048245001906	H-loop/switch region; other site
1048245001909	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1048245001910	putative active site [active]
1048245001911	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1048245001912	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
1048245001913	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1048245001915	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1048245001916	Sulfatase; Region: Sulfatase; pfam00884
1048245001917	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1048245001919	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1048245001920	oligomeric interface; other site
1048245001921	putative active site [active]
1048245001922	homodimer interface [polypeptide binding]; other site
1048245001923	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1048245001924	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1048245001925	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1048245001926	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1048245001927	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1048245001928	RPB10 interaction site [polypeptide binding]; other site
1048245001929	RPB1 interaction site [polypeptide binding]; other site
1048245001930	RPB11 interaction site [polypeptide binding]; other site
1048245001931	RPB3 interaction site [polypeptide binding]; other site
1048245001932	RPB12 interaction site [polypeptide binding]; other site
1048245001933	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1048245001934	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1048245001935	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1048245001936	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1048245001937	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
1048245001938	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1048245001939	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1048245001940	G-loop; other site
1048245001941	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1048245001942	DNA binding site [nucleotide binding]
1048245001943	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1048245001944	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734
1048245001946	endonuclease IV; Provisional; Region: PRK01060
1048245001947	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1048245001948	AP (apurinic/apyrimidinic) site pocket; other site
1048245001949	DNA interaction; other site
1048245001950	Metal-binding active site; metal-binding site
1048245001953	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
1048245001954	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1048245001956	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
1048245001957	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245001958	active site
1048245001960	enoyl-CoA hydratase; Provisional; Region: PRK12478
1048245001961	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245001962	substrate binding site [chemical binding]; other site
1048245001963	oxyanion hole (OAH) forming residues; other site
1048245001964	trimer interface [polypeptide binding]; other site
1048245001966	PaaX-like protein; Region: PaaX; pfam07848
1048245001967	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1048245001968	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1048245001969	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245001970	substrate binding site [chemical binding]; other site
1048245001971	oxyanion hole (OAH) forming residues; other site
1048245001972	trimer interface [polypeptide binding]; other site
1048245001975	putative transposase OrfB; Reviewed; Region: PHA02517
1048245001976	HTH-like domain; Region: HTH_21; pfam13276
1048245001977	Integrase core domain; Region: rve; pfam00665
1048245001978	Integrase core domain; Region: rve_3; pfam13683
1048245001979	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1048245001980	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
1048245001981	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
1048245001982	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245001983	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245001984	WHG domain; Region: WHG; pfam13305
1048245001985	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1048245001986	S17 interaction site [polypeptide binding]; other site
1048245001987	S8 interaction site; other site
1048245001988	16S rRNA interaction site [nucleotide binding]; other site
1048245001989	streptomycin interaction site [chemical binding]; other site
1048245001990	23S rRNA interaction site [nucleotide binding]; other site
1048245001991	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1048245001993	30S ribosomal protein S7; Validated; Region: PRK05302
1048245001995	elongation factor G; Reviewed; Region: PRK00007
1048245001996	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1048245001997	G1 box; other site
1048245001998	putative GEF interaction site [polypeptide binding]; other site
1048245001999	GTP/Mg2+ binding site [chemical binding]; other site
1048245002000	Switch I region; other site
1048245002001	G2 box; other site
1048245002002	G3 box; other site
1048245002003	Switch II region; other site
1048245002004	G4 box; other site
1048245002005	G5 box; other site
1048245002006	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1048245002007	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1048245002008	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1048245002011	elongation factor Tu; Reviewed; Region: PRK00049
1048245002012	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1048245002013	G1 box; other site
1048245002014	GEF interaction site [polypeptide binding]; other site
1048245002015	GTP/Mg2+ binding site [chemical binding]; other site
1048245002016	Switch I region; other site
1048245002017	G2 box; other site
1048245002018	G3 box; other site
1048245002019	Switch II region; other site
1048245002020	G4 box; other site
1048245002021	G5 box; other site
1048245002022	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
1048245002023	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1048245002024	Antibiotic Binding Site [chemical binding]; other site
1048245002027	Short C-terminal domain; Region: SHOCT; pfam09851
1048245002028	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
1048245002029	classical (c) SDRs; Region: SDR_c; cd05233
1048245002030	NAD(P) binding site [chemical binding]; other site
1048245002031	active site
1048245002033	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1048245002034	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1048245002035	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427
1048245002036	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1048245002037	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245002039	putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967
1048245002040	mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962
1048245002041	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1048245002042	FeS/SAM binding site; other site
1048245002043	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1048245002044	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
1048245002045	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1048245002046	phosphate binding site [ion binding]; other site
1048245002047	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
1048245002048	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
1048245002049	catalytic residues [active]
1048245002050	catalytic nucleophile [active]
1048245002052	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1048245002053	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1048245002054	Probable transposase; Region: OrfB_IS605; pfam01385
1048245002055	mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964
1048245002056	mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965
1048245002057	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1048245002058	active site
1048245002059	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1048245002060	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
1048245002061	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1048245002064	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1048245002065	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1048245002066	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1048245002068	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1048245002070	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1048245002071	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1048245002072	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1048245002073	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1048245002074	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1048245002076	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1048245002078	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1048245002079	putative translocon binding site; other site
1048245002080	protein-rRNA interface [nucleotide binding]; other site
1048245002082	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1048245002083	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1048245002084	G-X-X-G motif; other site
1048245002085	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1048245002086	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1048245002087	23S rRNA interface [nucleotide binding]; other site
1048245002088	5S rRNA interface [nucleotide binding]; other site
1048245002089	putative antibiotic binding site [chemical binding]; other site
1048245002090	L25 interface [polypeptide binding]; other site
1048245002091	L27 interface [polypeptide binding]; other site
1048245002093	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1048245002094	putative translocon interaction site; other site
1048245002095	23S rRNA interface [nucleotide binding]; other site
1048245002096	signal recognition particle (SRP54) interaction site; other site
1048245002097	L23 interface [polypeptide binding]; other site
1048245002098	trigger factor interaction site; other site
1048245002099	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1048245002101	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1048245002102	Sulfatase; Region: Sulfatase; pfam00884
1048245002103	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353
1048245002107	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1048245002108	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1048245002109	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1048245002111	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1048245002112	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1048245002113	RNA binding site [nucleotide binding]; other site
1048245002115	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1048245002116	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1048245002117	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1048245002118	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1048245002120	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1048245002122	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1048245002123	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1048245002124	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1048245002126	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1048245002127	5S rRNA interface [nucleotide binding]; other site
1048245002128	23S rRNA interface [nucleotide binding]; other site
1048245002129	L5 interface [polypeptide binding]; other site
1048245002130	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1048245002131	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1048245002132	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1048245002135	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1048245002136	23S rRNA binding site [nucleotide binding]; other site
1048245002137	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1048245002140	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
1048245002141	tandem repeat interface [polypeptide binding]; other site
1048245002142	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1048245002143	oligomer interface [polypeptide binding]; other site
1048245002144	active site residues [active]
1048245002145	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1048245002146	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1048245002147	tandem repeat interface [polypeptide binding]; other site
1048245002148	oligomer interface [polypeptide binding]; other site
1048245002149	active site residues [active]
1048245002150	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1048245002151	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1048245002152	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1048245002153	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1048245002154	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1048245002155	intersubunit interface [polypeptide binding]; other site
1048245002156	active site
1048245002157	Zn2+ binding site [ion binding]; other site
1048245002158	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1048245002159	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1048245002160	NAD binding site [chemical binding]; other site
1048245002161	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1048245002162	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1048245002163	nucleotide binding site [chemical binding]; other site
1048245002164	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1048245002165	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1048245002166	Coenzyme A binding pocket [chemical binding]; other site
1048245002167	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1048245002168	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1048245002169	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1048245002170	SecY translocase; Region: SecY; pfam00344
1048245002173	adenylate kinase; Reviewed; Region: adk; PRK00279
1048245002174	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1048245002175	AMP-binding site [chemical binding]; other site
1048245002176	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1048245002178	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1048245002179	active site
1048245002180	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
1048245002181	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1048245002182	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1048245002183	DNA binding residues [nucleotide binding]
1048245002185	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1048245002186	Putative zinc-finger; Region: zf-HC2; pfam13490
1048245002187	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1048245002188	MarR family; Region: MarR; pfam01047
1048245002189	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1048245002190	TIGR03086 family protein; Region: TIGR03086
1048245002192	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1048245002193	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1048245002194	Helix-turn-helix domain; Region: HTH_17; pfam12728
1048245002195	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1048245002196	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1048245002197	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1048245002198	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1048245002200	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245002201	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245002202	active site
1048245002205	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1048245002206	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1048245002207	tetrameric interface [polypeptide binding]; other site
1048245002208	NAD binding site [chemical binding]; other site
1048245002209	catalytic residues [active]
1048245002211	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1048245002212	catalytic core [active]
1048245002213	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245002214	PPE family; Region: PPE; pfam00823
1048245002215	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245002216	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1048245002217	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1048245002218	active site
1048245002219	phosphorylation site [posttranslational modification]
1048245002220	intermolecular recognition site; other site
1048245002221	dimerization interface [polypeptide binding]; other site
1048245002222	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1048245002223	DNA binding site [nucleotide binding]
1048245002224	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1048245002225	dimerization interface [polypeptide binding]; other site
1048245002226	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1048245002227	dimer interface [polypeptide binding]; other site
1048245002228	phosphorylation site [posttranslational modification]
1048245002229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1048245002230	ATP binding site [chemical binding]; other site
1048245002231	Mg2+ binding site [ion binding]; other site
1048245002232	G-X-G motif; other site
1048245002233	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1048245002234	nucleotide binding site/active site [active]
1048245002235	HIT family signature motif; other site
1048245002236	catalytic residue [active]
1048245002237	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
1048245002238	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
1048245002239	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1048245002240	NAD binding site [chemical binding]; other site
1048245002241	catalytic Zn binding site [ion binding]; other site
1048245002242	substrate binding site [chemical binding]; other site
1048245002243	structural Zn binding site [ion binding]; other site
1048245002245	SnoaL-like domain; Region: SnoaL_3; pfam13474
1048245002247	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1048245002248	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
1048245002249	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245002250	Cytochrome P450; Region: p450; cl12078
1048245002252	short chain dehydrogenase; Provisional; Region: PRK07775
1048245002253	classical (c) SDRs; Region: SDR_c; cd05233
1048245002254	NAD(P) binding site [chemical binding]; other site
1048245002255	active site
1048245002257	Cytochrome P450; Region: p450; cl12078
1048245002258	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245002260	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245002261	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
1048245002262	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
1048245002263	NAD binding site [chemical binding]; other site
1048245002264	catalytic residues [active]
1048245002266	short chain dehydrogenase; Provisional; Region: PRK07774
1048245002267	classical (c) SDRs; Region: SDR_c; cd05233
1048245002268	NAD(P) binding site [chemical binding]; other site
1048245002269	active site
1048245002270	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1048245002271	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1048245002272	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1048245002273	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1048245002274	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1048245002275	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1048245002276	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1048245002277	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1048245002278	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1048245002279	Predicted esterase [General function prediction only]; Region: COG0627
1048245002280	S-formylglutathione hydrolase; Region: PLN02442
1048245002283	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1048245002284	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
1048245002285	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1048245002286	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1048245002287	tetramer interface [polypeptide binding]; other site
1048245002289	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245002290	Cytochrome P450; Region: p450; cl12078
1048245002292	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1048245002293	ATP binding site [chemical binding]; other site
1048245002294	active site
1048245002295	substrate binding site [chemical binding]; other site
1048245002297	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1048245002298	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1048245002299	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1048245002300	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245002301	putative substrate translocation pore; other site
1048245002302	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245002303	Predicted deacetylase [General function prediction only]; Region: COG3233
1048245002304	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
1048245002305	putative active site [active]
1048245002306	putative Zn binding site [ion binding]; other site
1048245002307	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1048245002308	FAD binding domain; Region: FAD_binding_2; pfam00890
1048245002309	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1048245002310	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
1048245002311	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1048245002312	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1048245002313	putative active site [active]
1048245002314	catalytic triad [active]
1048245002316	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1048245002317	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1048245002318	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1048245002319	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
1048245002320	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1048245002321	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1048245002322	DNA-binding site [nucleotide binding]; DNA binding site
1048245002323	UTRA domain; Region: UTRA; pfam07702
1048245002324	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1048245002325	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1048245002326	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1048245002327	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1048245002328	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1048245002329	Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659
1048245002330	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
1048245002331	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
1048245002332	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
1048245002333	active site
1048245002334	metal binding site [ion binding]; metal-binding site
1048245002335	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1048245002336	active site
1048245002337	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1048245002339	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1048245002340	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1048245002341	dimerization interface [polypeptide binding]; other site
1048245002342	ATP binding site [chemical binding]; other site
1048245002343	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1048245002344	dimerization interface [polypeptide binding]; other site
1048245002345	ATP binding site [chemical binding]; other site
1048245002346	CAAX protease self-immunity; Region: Abi; pfam02517
1048245002348	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1048245002349	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1048245002350	active site
1048245002351	metal binding site [ion binding]; metal-binding site
1048245002352	hexamer interface [polypeptide binding]; other site
1048245002353	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
1048245002354	amidophosphoribosyltransferase; Provisional; Region: PRK07847
1048245002355	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1048245002356	active site
1048245002357	tetramer interface [polypeptide binding]; other site
1048245002358	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1048245002359	active site
1048245002361	phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878
1048245002362	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1048245002363	dimerization interface [polypeptide binding]; other site
1048245002364	putative ATP binding site [chemical binding]; other site
1048245002365	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
1048245002366	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1048245002367	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1048245002368	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1048245002369	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1048245002370	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245002371	catalytic residue [active]
1048245002372	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
1048245002373	heme-binding site [chemical binding]; other site
1048245002374	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
1048245002375	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1048245002376	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1048245002377	active site residue [active]
1048245002378	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1048245002379	active site residue [active]
1048245002382	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1048245002383	catalytic residues [active]
1048245002384	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1048245002385	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1048245002386	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1048245002387	DNA binding site [nucleotide binding]
1048245002388	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
1048245002389	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1048245002390	Coenzyme A binding pocket [chemical binding]; other site
1048245002391	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
1048245002392	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1048245002393	Walker A/P-loop; other site
1048245002394	ATP binding site [chemical binding]; other site
1048245002395	Q-loop/lid; other site
1048245002396	ABC transporter signature motif; other site
1048245002397	Walker B; other site
1048245002398	D-loop; other site
1048245002399	H-loop/switch region; other site
1048245002402	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1048245002403	PhoU domain; Region: PhoU; pfam01895
1048245002404	PhoU domain; Region: PhoU; pfam01895
1048245002405	cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350
1048245002406	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1048245002408	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1048245002409	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1048245002410	FMN binding site [chemical binding]; other site
1048245002411	active site
1048245002412	catalytic residues [active]
1048245002413	substrate binding site [chemical binding]; other site
1048245002415	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
1048245002416	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
1048245002417	homodimer interface [polypeptide binding]; other site
1048245002418	putative substrate binding pocket [chemical binding]; other site
1048245002419	diiron center [ion binding]; other site
1048245002421	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245002422	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
1048245002423	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1048245002424	dimerization interface [polypeptide binding]; other site
1048245002425	putative DNA binding site [nucleotide binding]; other site
1048245002426	putative Zn2+ binding site [ion binding]; other site
1048245002427	Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]; Region: CumB; COG0590
1048245002428	active site
1048245002429	Zn binding site [ion binding]; other site
1048245002431	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1048245002432	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1048245002433	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1048245002434	TIGR04255 family protein; Region: sporadTIGR04255
1048245002435	PE family; Region: PE; pfam00934
1048245002436	PE family; Region: PE; pfam00934
1048245002437	PknH-like extracellular domain; Region: PknH_C; pfam14032
1048245002439	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
1048245002440	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861
1048245002441	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
1048245002442	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
1048245002444	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245002445	S-adenosylmethionine binding site [chemical binding]; other site
1048245002446	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
1048245002447	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245002448	putative substrate translocation pore; other site
1048245002449	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1048245002450	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1048245002451	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1048245002452	tetramer interface [polypeptide binding]; other site
1048245002453	TPP-binding site [chemical binding]; other site
1048245002454	heterodimer interface [polypeptide binding]; other site
1048245002455	phosphorylation loop region [posttranslational modification]
1048245002456	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1048245002457	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1048245002458	active site
1048245002459	phosphorylation site [posttranslational modification]
1048245002460	intermolecular recognition site; other site
1048245002461	dimerization interface [polypeptide binding]; other site
1048245002462	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1048245002463	DNA binding residues [nucleotide binding]
1048245002464	dimerization interface [polypeptide binding]; other site
1048245002465	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1048245002466	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1048245002467	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1048245002468	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1048245002469	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1048245002470	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1048245002473	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1048245002474	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1048245002475	dimer interface [polypeptide binding]; other site
1048245002476	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245002477	catalytic residue [active]
1048245002478	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245002479	multidrug resistance protein MdtH; Provisional; Region: PRK11646
1048245002480	putative substrate translocation pore; other site
1048245002481	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
1048245002482	short chain dehydrogenase; Provisional; Region: PRK05876
1048245002483	classical (c) SDRs; Region: SDR_c; cd05233
1048245002484	NAD(P) binding site [chemical binding]; other site
1048245002485	active site
1048245002487	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245002489	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1048245002490	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1048245002491	dimer interface [polypeptide binding]; other site
1048245002492	PYR/PP interface [polypeptide binding]; other site
1048245002493	TPP binding site [chemical binding]; other site
1048245002494	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1048245002495	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1048245002496	TPP-binding site [chemical binding]; other site
1048245002497	dimer interface [polypeptide binding]; other site
1048245002500	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1048245002501	putative hydrophobic ligand binding site [chemical binding]; other site
1048245002502	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1048245002503	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1048245002504	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1048245002505	putative hydrophobic ligand binding site [chemical binding]; other site
1048245002506	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1048245002507	putative hydrophobic ligand binding site [chemical binding]; other site
1048245002508	aminotransferase; Validated; Region: PRK07777
1048245002509	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1048245002510	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245002511	homodimer interface [polypeptide binding]; other site
1048245002512	catalytic residue [active]
1048245002513	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
1048245002514	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1048245002515	dimer interface [polypeptide binding]; other site
1048245002516	active site
1048245002520	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
1048245002521	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245002522	substrate binding site [chemical binding]; other site
1048245002523	oxyanion hole (OAH) forming residues; other site
1048245002524	trimer interface [polypeptide binding]; other site
1048245002525	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1048245002526	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1048245002527	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1048245002528	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1048245002529	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1048245002530	ATP binding site [chemical binding]; other site
1048245002531	putative Mg++ binding site [ion binding]; other site
1048245002532	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1048245002533	nucleotide binding region [chemical binding]; other site
1048245002534	ATP-binding site [chemical binding]; other site
1048245002535	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1048245002536	WYL domain; Region: WYL; pfam13280
1048245002537	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1048245002538	trimer interface [polypeptide binding]; other site
1048245002539	dimer interface [polypeptide binding]; other site
1048245002540	putative active site [active]
1048245002541	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1048245002542	MPT binding site; other site
1048245002543	trimer interface [polypeptide binding]; other site
1048245002544	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1048245002545	MoaE homodimer interface [polypeptide binding]; other site
1048245002546	MoaD interaction [polypeptide binding]; other site
1048245002547	active site residues [active]
1048245002548	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1048245002549	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1048245002550	MoaE interaction surface [polypeptide binding]; other site
1048245002551	MoeB interaction surface [polypeptide binding]; other site
1048245002552	thiocarboxylated glycine; other site
1048245002553	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1048245002554	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1048245002555	FeS/SAM binding site; other site
1048245002556	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1048245002557	hypothetical protein; Provisional; Region: PRK11770
1048245002558	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1048245002559	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1048245002561	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1048245002562	DNA-binding site [nucleotide binding]; DNA binding site
1048245002563	RNA-binding motif; other site
1048245002565	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245002566	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245002567	active site
1048245002568	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
1048245002569	H+ Antiporter protein; Region: 2A0121; TIGR00900
1048245002570	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
1048245002571	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245002572	PPE family; Region: PPE; pfam00823
1048245002573	Protein of unknown function (DUF2530); Region: DUF2530; pfam10745
1048245002574	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1048245002575	MarR family; Region: MarR; pfam01047
1048245002576	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1048245002577	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1048245002578	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1048245002579	Protein of unknown function (DUF2537); Region: DUF2537; pfam10801
1048245002580	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
1048245002581	phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366
1048245002582	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1048245002583	catalytic residue [active]
1048245002584	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1048245002585	Ferredoxin [Energy production and conversion]; Region: COG1146
1048245002586	4Fe-4S binding domain; Region: Fer4; pfam00037
1048245002587	ferredoxin-NADP+ reductase; Region: PLN02852
1048245002588	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1048245002590	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1048245002591	putative dimer interface [polypeptide binding]; other site
1048245002592	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1048245002593	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1048245002594	putative catalytic site [active]
1048245002595	putative phosphate binding site [ion binding]; other site
1048245002596	putative metal binding site [ion binding]; other site
1048245002597	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
1048245002598	dimer interface [polypeptide binding]; other site
1048245002599	Citrate synthase; Region: Citrate_synt; pfam00285
1048245002600	active site
1048245002601	citrylCoA binding site [chemical binding]; other site
1048245002602	oxalacetate/citrate binding site [chemical binding]; other site
1048245002603	coenzyme A binding site [chemical binding]; other site
1048245002604	catalytic triad [active]
1048245002606	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1048245002607	cyclase homology domain; Region: CHD; cd07302
1048245002608	nucleotidyl binding site; other site
1048245002609	metal binding site [ion binding]; metal-binding site
1048245002610	dimer interface [polypeptide binding]; other site
1048245002611	AAA ATPase domain; Region: AAA_16; pfam13191
1048245002612	Predicted ATPase [General function prediction only]; Region: COG3903
1048245002613	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1048245002614	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1048245002615	DNA binding residues [nucleotide binding]
1048245002616	dimerization interface [polypeptide binding]; other site
1048245002619	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1048245002620	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1048245002621	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1048245002622	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1048245002623	AAA ATPase domain; Region: AAA_16; pfam13191
1048245002624	Predicted ATPase [General function prediction only]; Region: COG3903
1048245002626	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1048245002627	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1048245002628	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1048245002629	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1048245002630	dimer interface [polypeptide binding]; other site
1048245002631	active site
1048245002632	citrylCoA binding site [chemical binding]; other site
1048245002633	NADH binding [chemical binding]; other site
1048245002634	cationic pore residues; other site
1048245002635	oxalacetate/citrate binding site [chemical binding]; other site
1048245002636	coenzyme A binding site [chemical binding]; other site
1048245002637	catalytic triad [active]
1048245002639	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1048245002640	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1048245002641	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
1048245002642	BON domain; Region: BON; pfam04972
1048245002643	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1048245002644	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1048245002645	ligand binding site [chemical binding]; other site
1048245002647	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1048245002648	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1048245002649	dimerization interface [polypeptide binding]; other site
1048245002650	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1048245002651	dimer interface [polypeptide binding]; other site
1048245002652	phosphorylation site [posttranslational modification]
1048245002653	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1048245002654	Mg2+ binding site [ion binding]; other site
1048245002655	G-X-G motif; other site
1048245002656	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1048245002657	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1048245002658	active site
1048245002659	phosphorylation site [posttranslational modification]
1048245002660	intermolecular recognition site; other site
1048245002661	dimerization interface [polypeptide binding]; other site
1048245002662	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1048245002663	DNA binding site [nucleotide binding]
1048245002664	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
1048245002665	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825
1048245002666	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1048245002667	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245002668	substrate binding site [chemical binding]; other site
1048245002669	oxyanion hole (OAH) forming residues; other site
1048245002670	trimer interface [polypeptide binding]; other site
1048245002671	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1048245002672	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1048245002673	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1048245002674	Beta-lactamase; Region: Beta-lactamase; pfam00144
1048245002675	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
1048245002676	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1048245002677	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1048245002678	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1048245002680	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
1048245002681	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1048245002682	hydrophobic ligand binding site; other site
1048245002683	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1048245002684	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1048245002685	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1048245002686	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1048245002687	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
1048245002688	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
1048245002689	acetyl-CoA acetyltransferase; Provisional; Region: PRK06289
1048245002690	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1048245002691	active site
1048245002692	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245002693	PPE family; Region: PPE; pfam00823
1048245002695	PE family; Region: PE; pfam00934
1048245002696	BCCT family transporter; Region: BCCT; pfam02028
1048245002697	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
1048245002698	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1048245002699	Coenzyme A binding pocket [chemical binding]; other site
1048245002700	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1048245002701	MULE transposase domain; Region: MULE; pfam10551
1048245002703	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
1048245002704	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
1048245002705	catalytic residues [active]
1048245002706	catalytic nucleophile [active]
1048245002707	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1048245002708	Probable transposase; Region: OrfB_IS605; pfam01385
1048245002709	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1048245002710	putative active site pocket [active]
1048245002711	dimerization interface [polypeptide binding]; other site
1048245002712	putative catalytic residue [active]
1048245002713	Phage-related replication protein [General function prediction only]; Region: COG4195
1048245002715	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
1048245002716	short chain dehydrogenase; Provisional; Region: PRK07814
1048245002717	classical (c) SDRs; Region: SDR_c; cd05233
1048245002718	NAD(P) binding site [chemical binding]; other site
1048245002719	active site
1048245002722	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
1048245002724	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
1048245002725	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245002726	dimer interface [polypeptide binding]; other site
1048245002727	conserved gate region; other site
1048245002728	putative PBP binding loops; other site
1048245002729	ABC-ATPase subunit interface; other site
1048245002731	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1048245002732	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245002733	dimer interface [polypeptide binding]; other site
1048245002734	conserved gate region; other site
1048245002735	putative PBP binding loops; other site
1048245002736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1048245002737	ABC-ATPase subunit interface; other site
1048245002738	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1048245002739	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1048245002740	active site
1048245002741	ATP binding site [chemical binding]; other site
1048245002742	substrate binding site [chemical binding]; other site
1048245002743	activation loop (A-loop); other site
1048245002744	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1048245002745	NHL repeat; Region: NHL; pfam01436
1048245002746	NHL repeat; Region: NHL; pfam01436
1048245002747	NHL repeat; Region: NHL; pfam01436
1048245002748	NHL repeat; Region: NHL; pfam01436
1048245002749	NHL repeat; Region: NHL; pfam01436
1048245002752	PBP superfamily domain; Region: PBP_like_2; cl17296
1048245002754	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271
1048245002755	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1048245002756	Walker A/P-loop; other site
1048245002757	ATP binding site [chemical binding]; other site
1048245002758	Q-loop/lid; other site
1048245002759	ABC transporter signature motif; other site
1048245002760	Walker B; other site
1048245002761	D-loop; other site
1048245002762	H-loop/switch region; other site
1048245002765	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
1048245002767	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
1048245002768	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245002769	dimer interface [polypeptide binding]; other site
1048245002770	conserved gate region; other site
1048245002771	putative PBP binding loops; other site
1048245002772	ABC-ATPase subunit interface; other site
1048245002774	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1048245002775	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245002776	dimer interface [polypeptide binding]; other site
1048245002777	conserved gate region; other site
1048245002778	putative PBP binding loops; other site
1048245002779	ABC-ATPase subunit interface; other site
1048245002781	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1048245002782	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1048245002783	putative DNA binding site [nucleotide binding]; other site
1048245002784	putative homodimer interface [polypeptide binding]; other site
1048245002785	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
1048245002786	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
1048245002787	nucleotide binding site [chemical binding]; other site
1048245002788	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
1048245002789	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1048245002790	active site
1048245002791	DNA binding site [nucleotide binding]
1048245002792	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1048245002793	DNA binding site [nucleotide binding]
1048245002794	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1048245002795	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1048245002796	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1048245002797	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1048245002798	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1048245002799	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1048245002800	anti sigma factor interaction site; other site
1048245002801	regulatory phosphorylation site [posttranslational modification]; other site
1048245002802	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1048245002803	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1048245002804	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
1048245002805	homodimer interface [polypeptide binding]; other site
1048245002806	active site
1048245002807	SAM binding site [chemical binding]; other site
1048245002808	PE family; Region: PE; pfam00934
1048245002809	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1048245002810	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
1048245002811	putative DNA binding site [nucleotide binding]; other site
1048245002812	catalytic residue [active]
1048245002813	putative H2TH interface [polypeptide binding]; other site
1048245002814	putative catalytic residues [active]
1048245002815	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1048245002816	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1048245002817	short chain dehydrogenase; Provisional; Region: PRK08251
1048245002818	classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350
1048245002819	putative NAD(P) binding site [chemical binding]; other site
1048245002820	active site
1048245002822	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1048245002823	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1048245002824	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1048245002825	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1048245002826	active site
1048245002827	dimer interface [polypeptide binding]; other site
1048245002828	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1048245002829	dimer interface [polypeptide binding]; other site
1048245002830	active site
1048245002833	hypothetical protein; Provisional; Region: PRK07857
1048245002834	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1048245002835	Part of AAA domain; Region: AAA_19; pfam13245
1048245002836	Family description; Region: UvrD_C_2; pfam13538
1048245002838	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1048245002839	Peptidase family M23; Region: Peptidase_M23; pfam01551
1048245002840	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1048245002841	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1048245002842	CoA-ligase; Region: Ligase_CoA; pfam00549
1048245002843	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1048245002844	CoA binding domain; Region: CoA_binding; smart00881
1048245002845	CoA-ligase; Region: Ligase_CoA; pfam00549
1048245002847	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1048245002848	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1048245002850	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1048245002851	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1048245002852	active site
1048245002853	substrate binding site [chemical binding]; other site
1048245002854	cosubstrate binding site; other site
1048245002855	catalytic site [active]
1048245002856	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1048245002857	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1048245002858	purine monophosphate binding site [chemical binding]; other site
1048245002859	dimer interface [polypeptide binding]; other site
1048245002860	putative catalytic residues [active]
1048245002861	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1048245002862	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1048245002863	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
1048245002864	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1048245002866	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
1048245002867	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1048245002868	metal ion-dependent adhesion site (MIDAS); other site
1048245002869	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
1048245002870	homotetrameric interface [polypeptide binding]; other site
1048245002871	putative active site [active]
1048245002872	metal binding site [ion binding]; metal-binding site
1048245002873	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
1048245002875	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1048245002876	Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151
1048245002877	putative homodimer interface [polypeptide binding]; other site
1048245002878	putative homotetramer interface [polypeptide binding]; other site
1048245002879	allosteric switch controlling residues; other site
1048245002880	putative metal binding site [ion binding]; other site
1048245002881	putative homodimer-homodimer interface [polypeptide binding]; other site
1048245002882	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
1048245002883	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1048245002884	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1048245002885	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1048245002887	enoyl-CoA hydratase; Provisional; Region: PRK07827
1048245002888	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245002889	substrate binding site [chemical binding]; other site
1048245002890	oxyanion hole (OAH) forming residues; other site
1048245002891	trimer interface [polypeptide binding]; other site
1048245002892	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245002893	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1048245002894	active site
1048245002895	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1048245002896	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1048245002897	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1048245002898	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1048245002899	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1048245002900	carboxyltransferase (CT) interaction site; other site
1048245002901	biotinylation site [posttranslational modification]; other site
1048245002904	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1048245002905	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1048245002906	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245002907	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245002908	active site
1048245002910	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
1048245002911	PE family; Region: PE; pfam00934
1048245002912	PE family; Region: PE; pfam00934
1048245002913	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1048245002914	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1048245002915	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1048245002917	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1048245002918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1048245002919	active site
1048245002920	phosphorylation site [posttranslational modification]
1048245002921	intermolecular recognition site; other site
1048245002922	dimerization interface [polypeptide binding]; other site
1048245002923	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1048245002924	DNA binding site [nucleotide binding]
1048245002926	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1048245002927	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1048245002928	dimerization interface [polypeptide binding]; other site
1048245002929	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1048245002930	dimer interface [polypeptide binding]; other site
1048245002931	phosphorylation site [posttranslational modification]
1048245002932	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1048245002933	ATP binding site [chemical binding]; other site
1048245002934	Mg2+ binding site [ion binding]; other site
1048245002935	G-X-G motif; other site
1048245002936	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1048245002937	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1048245002938	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1048245002939	MPT binding site; other site
1048245002940	trimer interface [polypeptide binding]; other site
1048245002941	Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741
1048245002942	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1048245002943	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1048245002944	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1048245002945	Walker A/P-loop; other site
1048245002946	ATP binding site [chemical binding]; other site
1048245002947	Q-loop/lid; other site
1048245002948	ABC transporter signature motif; other site
1048245002949	Walker B; other site
1048245002950	D-loop; other site
1048245002951	H-loop/switch region; other site
1048245002954	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1048245002955	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1048245002956	FtsX-like permease family; Region: FtsX; pfam02687
1048245002957	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1048245002958	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1048245002959	FtsX-like permease family; Region: FtsX; pfam02687
1048245002961	Predicted secreted hydrolase [General function prediction only]; Region: COG5621
1048245002962	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1048245002963	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1048245002964	substrate binding pocket [chemical binding]; other site
1048245002965	chain length determination region; other site
1048245002966	substrate-Mg2+ binding site; other site
1048245002967	catalytic residues [active]
1048245002968	aspartate-rich region 1; other site
1048245002969	active site lid residues [active]
1048245002970	aspartate-rich region 2; other site
1048245002971	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1048245002972	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331
1048245002973	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
1048245002974	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1048245002975	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
1048245002976	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1048245002977	active site
1048245002978	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1048245002979	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1048245002980	dimer interface [polypeptide binding]; other site
1048245002981	putative functional site; other site
1048245002982	putative MPT binding site; other site
1048245002983	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1048245002984	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1048245002985	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1048245002986	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1048245002987	ligand binding site [chemical binding]; other site
1048245002988	flexible hinge region; other site
1048245002989	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1048245002990	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1048245002991	Coenzyme A binding pocket [chemical binding]; other site
1048245002993	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
1048245002994	arginine deiminase; Provisional; Region: PRK01388
1048245002995	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
1048245002996	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1048245002998	Predicted methyltransferases [General function prediction only]; Region: COG0313
1048245002999	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1048245003000	putative SAM binding site [chemical binding]; other site
1048245003001	putative homodimer interface [polypeptide binding]; other site
1048245003002	aminodeoxychorismate synthase component I; Provisional; Region: PRK05877
1048245003003	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
1048245003004	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
1048245003005	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1048245003006	active site
1048245003007	HIGH motif; other site
1048245003008	KMSKS motif; other site
1048245003009	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1048245003010	tRNA binding surface [nucleotide binding]; other site
1048245003011	anticodon binding site; other site
1048245003013	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1048245003014	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1048245003015	active site
1048245003018	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
1048245003019	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1048245003020	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1048245003021	G5 domain; Region: G5; pfam07501
1048245003022	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1048245003024	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1048245003025	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245003026	S-adenosylmethionine binding site [chemical binding]; other site
1048245003028	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
1048245003029	Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311
1048245003030	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1048245003031	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
1048245003032	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245003033	acyl-activating enzyme (AAE) consensus motif; other site
1048245003034	AMP binding site [chemical binding]; other site
1048245003035	active site
1048245003036	CoA binding site [chemical binding]; other site
1048245003038	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1048245003039	putative active site [active]
1048245003040	catalytic residue [active]
1048245003041	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1048245003042	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
1048245003043	5S rRNA interface [nucleotide binding]; other site
1048245003044	CTC domain interface [polypeptide binding]; other site
1048245003045	L16 interface [polypeptide binding]; other site
1048245003046	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
1048245003048	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1048245003049	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
1048245003050	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1048245003051	active site
1048245003054	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
1048245003055	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1048245003056	Substrate binding site; other site
1048245003057	Mg++ binding site; other site
1048245003058	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1048245003059	active site
1048245003060	substrate binding site [chemical binding]; other site
1048245003061	CoA binding site [chemical binding]; other site
1048245003062	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245003063	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245003064	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1048245003065	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1048245003066	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1048245003067	ATP binding site [chemical binding]; other site
1048245003068	putative Mg++ binding site [ion binding]; other site
1048245003069	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1048245003070	nucleotide binding region [chemical binding]; other site
1048245003071	ATP-binding site [chemical binding]; other site
1048245003072	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1048245003074	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
1048245003075	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1048245003076	homodimer interface [polypeptide binding]; other site
1048245003077	metal binding site [ion binding]; metal-binding site
1048245003078	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
1048245003079	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
1048245003080	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1048245003081	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1048245003083	enolase; Provisional; Region: eno; PRK00077
1048245003084	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1048245003085	dimer interface [polypeptide binding]; other site
1048245003086	metal binding site [ion binding]; metal-binding site
1048245003087	substrate binding pocket [chemical binding]; other site
1048245003088	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1048245003089	Septum formation initiator; Region: DivIC; pfam04977
1048245003090	Uncharacterized conserved protein [Function unknown]; Region: COG1507
1048245003091	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1048245003092	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1048245003093	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
1048245003094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1048245003095	active site
1048245003096	phosphorylation site [posttranslational modification]
1048245003097	intermolecular recognition site; other site
1048245003098	dimerization interface [polypeptide binding]; other site
1048245003099	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1048245003100	DNA binding site [nucleotide binding]
1048245003101	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1048245003102	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1048245003103	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1048245003104	Ligand Binding Site [chemical binding]; other site
1048245003105	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1048245003106	dimer interface [polypeptide binding]; other site
1048245003107	phosphorylation site [posttranslational modification]
1048245003108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1048245003109	ATP binding site [chemical binding]; other site
1048245003110	Mg2+ binding site [ion binding]; other site
1048245003111	G-X-G motif; other site
1048245003113	K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680
1048245003114	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1048245003115	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1048245003116	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1048245003118	K+-transporting ATPase, c chain; Region: KdpC; cl00944
1048245003119	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1048245003120	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1048245003121	dimer interface [polypeptide binding]; other site
1048245003122	phosphorylation site [posttranslational modification]
1048245003123	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1048245003124	ATP binding site [chemical binding]; other site
1048245003125	Mg2+ binding site [ion binding]; other site
1048245003126	G-X-G motif; other site
1048245003127	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1048245003128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1048245003129	active site
1048245003130	phosphorylation site [posttranslational modification]
1048245003131	intermolecular recognition site; other site
1048245003132	dimerization interface [polypeptide binding]; other site
1048245003133	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1048245003134	DNA binding site [nucleotide binding]
1048245003136	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
1048245003137	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1048245003138	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1048245003139	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245003140	PPE family; Region: PPE; pfam00823
1048245003141	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245003142	PE family; Region: PE; pfam00934
1048245003143	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245003144	Integrase core domain; Region: rve; pfam00665
1048245003145	Integrase core domain; Region: rve_3; pfam13683
1048245003146	Uncharacterized conserved protein [Function unknown]; Region: COG2253
1048245003147	Protein of unknown function (DUF2005); Region: DUF2005; pfam09407
1048245003148	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1048245003149	active site
1048245003150	DNA binding site [nucleotide binding]
1048245003151	Int/Topo IB signature motif; other site
1048245003152	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1048245003153	active site
1048245003154	catalytic residues [active]
1048245003155	DNA binding site [nucleotide binding]
1048245003156	Int/Topo IB signature motif; other site
1048245003157	Protein of unknown function (DUF3631); Region: DUF3631; pfam12307
1048245003158	Phage Terminase; Region: Terminase_1; pfam03354
1048245003159	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
1048245003160	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
1048245003161	Phage capsid family; Region: Phage_capsid; pfam05065
1048245003162	Phage capsid family; Region: Phage_capsid; pfam05065
1048245003163	Domain of unknown function (DUF427); Region: DUF427; cl00998
1048245003164	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
1048245003165	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1048245003166	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1048245003167	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
1048245003168	dimer interface [polypeptide binding]; other site
1048245003169	acyl-activating enzyme (AAE) consensus motif; other site
1048245003170	putative active site [active]
1048245003171	AMP binding site [chemical binding]; other site
1048245003172	putative CoA binding site [chemical binding]; other site
1048245003174	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
1048245003175	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
1048245003176	hydrophobic ligand binding site; other site
1048245003177	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1048245003178	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1048245003179	putative active site [active]
1048245003180	putative dimer interface [polypeptide binding]; other site
1048245003181	Patatin-like phospholipase; Region: Patatin; pfam01734
1048245003182	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1048245003183	nucleophile elbow; other site
1048245003184	hypothetical protein; Provisional; Region: PRK10279
1048245003185	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
1048245003186	active site
1048245003187	nucleophile elbow; other site
1048245003189	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
1048245003190	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1048245003191	active site residue [active]
1048245003192	PE family; Region: PE; pfam00934
1048245003193	PE family; Region: PE; pfam00934
1048245003194	Predicted membrane protein [Function unknown]; Region: COG4425
1048245003195	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
1048245003196	enoyl-CoA hydratase; Provisional; Region: PRK05862
1048245003197	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245003198	substrate binding site [chemical binding]; other site
1048245003199	oxyanion hole (OAH) forming residues; other site
1048245003200	trimer interface [polypeptide binding]; other site
1048245003202	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1048245003203	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245003204	substrate binding site [chemical binding]; other site
1048245003205	oxyanion hole (OAH) forming residues; other site
1048245003206	trimer interface [polypeptide binding]; other site
1048245003207	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1048245003208	Predicted membrane protein [Function unknown]; Region: COG4760
1048245003209	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1048245003210	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1048245003211	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
1048245003212	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1048245003213	dimer interface [polypeptide binding]; other site
1048245003214	active site
1048245003217	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
1048245003218	active site
1048245003219	catalytic triad [active]
1048245003220	oxyanion hole [active]
1048245003221	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1048245003222	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1048245003223	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
1048245003224	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1048245003225	dimer interface [polypeptide binding]; other site
1048245003226	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245003227	catalytic residue [active]
1048245003228	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
1048245003230	RDD family; Region: RDD; pfam06271
1048245003231	cystathionine gamma-synthase; Provisional; Region: PRK07811
1048245003232	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1048245003233	homodimer interface [polypeptide binding]; other site
1048245003234	substrate-cofactor binding pocket; other site
1048245003235	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245003236	catalytic residue [active]
1048245003238	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1048245003239	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1048245003240	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1048245003241	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1048245003242	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1048245003245	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
1048245003246	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
1048245003247	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
1048245003248	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
1048245003249	catalytic residues [active]
1048245003250	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
1048245003251	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1048245003252	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1048245003253	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1048245003254	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1048245003255	catalytic residue [active]
1048245003256	putative FPP diphosphate  binding site; other site
1048245003257	putative FPP binding hydrophobic cleft; other site
1048245003258	dimer interface [polypeptide binding]; other site
1048245003259	putative IPP diphosphate binding site; other site
1048245003261	PE family; Region: PE; pfam00934
1048245003263	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1048245003264	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1048245003265	putative IPP diphosphate binding site; other site
1048245003266	PE family; Region: PE; pfam00934
1048245003267	Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670
1048245003268	PE family; Region: PE; pfam00934
1048245003269	pantothenate kinase; Provisional; Region: PRK05439
1048245003270	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1048245003271	ATP-binding site [chemical binding]; other site
1048245003272	CoA-binding site [chemical binding]; other site
1048245003273	Mg2+-binding site [ion binding]; other site
1048245003275	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1048245003276	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1048245003277	dimer interface [polypeptide binding]; other site
1048245003278	active site
1048245003279	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1048245003280	folate binding site [chemical binding]; other site
1048245003281	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1048245003282	dinuclear metal binding motif [ion binding]; other site
1048245003283	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1048245003284	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1048245003285	putative active site [active]
1048245003286	PhoH-like protein; Region: PhoH; pfam02562
1048245003288	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1048245003289	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1048245003290	NodB motif; other site
1048245003291	active site
1048245003292	catalytic site [active]
1048245003293	metal binding site [ion binding]; metal-binding site
1048245003294	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1048245003295	Class II fumarases; Region: Fumarase_classII; cd01362
1048245003296	active site
1048245003297	tetramer interface [polypeptide binding]; other site
1048245003299	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1048245003300	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1048245003301	putative active site [active]
1048245003302	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
1048245003303	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1048245003304	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1048245003306	putative transposase OrfB; Reviewed; Region: PHA02517
1048245003307	HTH-like domain; Region: HTH_21; pfam13276
1048245003308	Integrase core domain; Region: rve; pfam00665
1048245003309	Integrase core domain; Region: rve_3; pfam13683
1048245003310	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1048245003311	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1048245003312	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1048245003313	3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241
1048245003314	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
1048245003315	putative NAD(P) binding site [chemical binding]; other site
1048245003316	active site
1048245003317	putative substrate binding site [chemical binding]; other site
1048245003318	exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280
1048245003319	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
1048245003320	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1048245003321	generic binding surface II; other site
1048245003322	generic binding surface I; other site
1048245003323	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1048245003324	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1048245003325	GTP-binding protein YchF; Reviewed; Region: PRK09601
1048245003326	YchF GTPase; Region: YchF; cd01900
1048245003327	G1 box; other site
1048245003328	GTP/Mg2+ binding site [chemical binding]; other site
1048245003329	Switch I region; other site
1048245003330	G2 box; other site
1048245003331	Switch II region; other site
1048245003332	G3 box; other site
1048245003333	G4 box; other site
1048245003334	G5 box; other site
1048245003335	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1048245003337	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
1048245003338	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487
1048245003339	putative active site [active]
1048245003340	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1048245003341	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1048245003342	cyclase homology domain; Region: CHD; cd07302
1048245003343	nucleotidyl binding site; other site
1048245003344	metal binding site [ion binding]; metal-binding site
1048245003345	dimer interface [polypeptide binding]; other site
1048245003346	glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871
1048245003347	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1048245003348	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1048245003349	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1048245003350	6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872
1048245003351	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1048245003353	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245003354	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1048245003355	pyruvate phosphate dikinase; Provisional; Region: PRK05878
1048245003356	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1048245003357	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
1048245003358	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245003359	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245003360	active site
1048245003361	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1048245003362	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1048245003363	non-specific DNA binding site [nucleotide binding]; other site
1048245003364	salt bridge; other site
1048245003365	sequence-specific DNA binding site [nucleotide binding]; other site
1048245003366	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1048245003367	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1048245003368	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1048245003370	citrate synthase; Provisional; Region: PRK14033
1048245003371	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
1048245003372	oxalacetate binding site [chemical binding]; other site
1048245003373	citrylCoA binding site [chemical binding]; other site
1048245003374	coenzyme A binding site [chemical binding]; other site
1048245003375	catalytic triad [active]
1048245003377	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
1048245003378	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1048245003379	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1048245003380	THF binding site; other site
1048245003381	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1048245003382	substrate binding site [chemical binding]; other site
1048245003383	THF binding site; other site
1048245003384	zinc-binding site [ion binding]; other site
1048245003385	PPE family; Region: PPE; pfam00823
1048245003386	PPE family; Region: PPE; pfam00823
1048245003387	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1048245003388	active site
1048245003389	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1048245003390	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245003391	substrate binding site [chemical binding]; other site
1048245003392	oxyanion hole (OAH) forming residues; other site
1048245003393	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1048245003394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
1048245003395	CAAX protease self-immunity; Region: Abi; pfam02517
1048245003396	enoyl-CoA hydratase; Provisional; Region: PRK06688
1048245003397	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
1048245003398	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245003399	trimer interface [polypeptide binding]; other site
1048245003400	enoyl-CoA hydratase; Provisional; Region: PRK06688
1048245003401	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245003402	substrate binding site [chemical binding]; other site
1048245003403	oxyanion hole (OAH) forming residues; other site
1048245003404	trimer interface [polypeptide binding]; other site
1048245003405	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1048245003406	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1048245003407	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
1048245003408	NAD binding site [chemical binding]; other site
1048245003409	homodimer interface [polypeptide binding]; other site
1048245003410	homotetramer interface [polypeptide binding]; other site
1048245003411	active site
1048245003413	MMPL family; Region: MMPL; pfam03176
1048245003414	MMPL family; Region: MMPL; pfam03176
1048245003415	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245003416	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245003417	active site
1048245003418	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1048245003419	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1048245003420	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1048245003421	NAD-dependent deacetylase; Provisional; Region: PRK00481
1048245003422	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
1048245003423	NAD+ binding site [chemical binding]; other site
1048245003424	substrate binding site [chemical binding]; other site
1048245003425	Zn binding site [ion binding]; other site
1048245003426	Predicted transcriptional regulators [Transcription]; Region: COG1725
1048245003427	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1048245003428	DNA-binding site [nucleotide binding]; DNA binding site
1048245003429	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1048245003430	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1048245003431	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
1048245003432	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1048245003433	uncharacterized HhH-GPD family protein; Region: TIGR03252
1048245003434	minor groove reading motif; other site
1048245003435	helix-hairpin-helix signature motif; other site
1048245003436	mannosyltransferase; Provisional; Region: pimE; PRK13375
1048245003437	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
1048245003438	aromatic arch; other site
1048245003439	DCoH dimer interaction site [polypeptide binding]; other site
1048245003440	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1048245003441	DCoH tetramer interaction site [polypeptide binding]; other site
1048245003442	substrate binding site [chemical binding]; other site
1048245003443	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1048245003444	active site
1048245003445	8-oxo-dGMP binding site [chemical binding]; other site
1048245003446	nudix motif; other site
1048245003447	metal binding site [ion binding]; metal-binding site
1048245003449	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1048245003450	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1048245003451	[4Fe-4S] binding site [ion binding]; other site
1048245003452	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1048245003453	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1048245003454	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1048245003455	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1048245003456	molybdopterin cofactor binding site; other site
1048245003459	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1048245003460	nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684
1048245003461	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1048245003462	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1048245003463	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1048245003464	G1 box; other site
1048245003465	putative GEF interaction site [polypeptide binding]; other site
1048245003466	GTP/Mg2+ binding site [chemical binding]; other site
1048245003467	Switch I region; other site
1048245003468	G2 box; other site
1048245003469	G3 box; other site
1048245003470	Switch II region; other site
1048245003471	G4 box; other site
1048245003472	G5 box; other site
1048245003473	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1048245003474	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1048245003475	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1048245003476	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1048245003477	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1048245003479	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245003480	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245003481	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245003482	PPE family; Region: PPE; pfam00823
1048245003483	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245003484	PE family; Region: PE; pfam00934
1048245003485	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
1048245003486	PE family; Region: PE; pfam00934
1048245003487	FO synthase; Reviewed; Region: fbiC; PRK09234
1048245003488	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1048245003489	FeS/SAM binding site; other site
1048245003490	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1048245003491	FeS/SAM binding site; other site
1048245003492	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1048245003493	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
1048245003494	active site
1048245003495	FMN binding site [chemical binding]; other site
1048245003496	2,4-decadienoyl-CoA binding site; other site
1048245003497	catalytic residue [active]
1048245003498	4Fe-4S cluster binding site [ion binding]; other site
1048245003499	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1048245003500	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1048245003501	Predicted transcriptional regulators [Transcription]; Region: COG1695
1048245003502	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1048245003503	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1048245003504	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
1048245003505	4Fe-4S binding domain; Region: Fer4; pfam00037
1048245003507	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
1048245003508	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1048245003509	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245003510	homodimer interface [polypeptide binding]; other site
1048245003511	catalytic residue [active]
1048245003513	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1048245003514	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
1048245003515	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1048245003516	ATP binding site [chemical binding]; other site
1048245003517	putative Mg++ binding site [ion binding]; other site
1048245003518	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1048245003519	nucleotide binding region [chemical binding]; other site
1048245003520	ATP-binding site [chemical binding]; other site
1048245003521	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1048245003522	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245003523	active site
1048245003526	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1048245003527	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1048245003528	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1048245003529	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245003530	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1048245003531	Enoylreductase; Region: PKS_ER; smart00829
1048245003532	NAD(P) binding site [chemical binding]; other site
1048245003533	KR domain; Region: KR; pfam08659
1048245003534	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1048245003535	putative NADP binding site [chemical binding]; other site
1048245003536	active site
1048245003537	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245003538	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1048245003539	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1048245003540	PE-PPE domain; Region: PE-PPE; pfam08237
1048245003541	acyl-CoA synthetase; Validated; Region: PRK05850
1048245003542	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1048245003543	acyl-activating enzyme (AAE) consensus motif; other site
1048245003544	active site
1048245003545	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1048245003546	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1048245003547	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
1048245003548	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
1048245003549	Glutamate binding site [chemical binding]; other site
1048245003550	NAD binding site [chemical binding]; other site
1048245003551	catalytic residues [active]
1048245003552	Proline dehydrogenase; Region: Pro_dh; cl03282
1048245003553	RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635
1048245003554	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1048245003555	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1048245003556	DNA binding residues [nucleotide binding]
1048245003557	haloalkane dehalogenase; Provisional; Region: PRK03204
1048245003558	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1048245003559	catalytic site [active]
1048245003560	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245003561	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
1048245003563	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1048245003564	PGAP1-like protein; Region: PGAP1; pfam07819
1048245003566	acyl-CoA synthetase; Validated; Region: PRK07787
1048245003567	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245003568	acyl-activating enzyme (AAE) consensus motif; other site
1048245003569	AMP binding site [chemical binding]; other site
1048245003570	active site
1048245003571	CoA binding site [chemical binding]; other site
1048245003573	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1048245003574	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1048245003575	PE family; Region: PE; pfam00934
1048245003576	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245003577	PPE family; Region: PPE; pfam00823
1048245003578	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245003579	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1048245003580	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1048245003581	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1048245003582	MULE transposase domain; Region: MULE; pfam10551
1048245003585	metabolite-proton symporter; Region: 2A0106; TIGR00883
1048245003586	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245003587	putative substrate translocation pore; other site
1048245003589	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
1048245003590	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
1048245003591	putative trimer interface [polypeptide binding]; other site
1048245003592	putative CoA binding site [chemical binding]; other site
1048245003593	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
1048245003594	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
1048245003595	metal binding site [ion binding]; metal-binding site
1048245003596	putative dimer interface [polypeptide binding]; other site
1048245003598	TIGR00730 family protein; Region: TIGR00730
1048245003599	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
1048245003600	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
1048245003601	acyl-activating enzyme (AAE) consensus motif; other site
1048245003602	putative AMP binding site [chemical binding]; other site
1048245003603	putative active site [active]
1048245003604	putative CoA binding site [chemical binding]; other site
1048245003607	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1048245003608	dihydropteroate synthase; Region: DHPS; TIGR01496
1048245003609	substrate binding pocket [chemical binding]; other site
1048245003610	dimer interface [polypeptide binding]; other site
1048245003611	inhibitor binding site; inhibition site
1048245003614	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
1048245003615	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1048245003616	DivIVA domain; Region: DivI1A_domain; TIGR03544
1048245003617	DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624
1048245003618	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
1048245003619	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
1048245003620	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1048245003621	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
1048245003622	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1048245003623	ligand binding site; other site
1048245003624	oligomer interface; other site
1048245003625	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1048245003626	dimer interface [polypeptide binding]; other site
1048245003627	N-terminal domain interface [polypeptide binding]; other site
1048245003628	sulfate 1 binding site; other site
1048245003629	PE family; Region: PE; pfam00934
1048245003630	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
1048245003631	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1048245003632	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
1048245003633	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1048245003634	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
1048245003635	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1048245003636	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1048245003637	Walker A/P-loop; other site
1048245003638	ATP binding site [chemical binding]; other site
1048245003639	Q-loop/lid; other site
1048245003640	ABC transporter signature motif; other site
1048245003641	Walker B; other site
1048245003642	D-loop; other site
1048245003643	H-loop/switch region; other site
1048245003644	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1048245003647	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245003648	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1048245003649	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245003650	S-adenosylmethionine binding site [chemical binding]; other site
1048245003651	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
1048245003652	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1048245003653	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1048245003654	DNA binding residues [nucleotide binding]
1048245003655	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1048245003656	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1048245003657	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1048245003658	protein binding site [polypeptide binding]; other site
1048245003660	sec-independent translocase; Provisional; Region: PRK03100
1048245003661	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1048245003662	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1048245003663	active site
1048245003664	motif I; other site
1048245003665	motif II; other site
1048245003666	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1048245003667	Predicted membrane protein [Function unknown]; Region: COG3428
1048245003668	Bacterial PH domain; Region: DUF304; pfam03703
1048245003669	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1048245003671	Domain of unknown function DUF59; Region: DUF59; cl00941
1048245003672	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1048245003673	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1048245003675	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
1048245003676	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1048245003677	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1048245003678	catalytic residue [active]
1048245003679	Predicted membrane protein [Function unknown]; Region: COG4420
1048245003680	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1048245003681	MgtE intracellular N domain; Region: MgtE_N; smart00924
1048245003682	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1048245003683	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
1048245003684	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1048245003685	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1048245003687	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245003688	dimer interface [polypeptide binding]; other site
1048245003689	conserved gate region; other site
1048245003690	putative PBP binding loops; other site
1048245003691	ABC-ATPase subunit interface; other site
1048245003693	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1048245003694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245003695	dimer interface [polypeptide binding]; other site
1048245003696	conserved gate region; other site
1048245003697	ABC-ATPase subunit interface; other site
1048245003698	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1048245003699	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1048245003700	Walker A/P-loop; other site
1048245003701	ATP binding site [chemical binding]; other site
1048245003702	Q-loop/lid; other site
1048245003703	ABC transporter signature motif; other site
1048245003704	Walker B; other site
1048245003705	D-loop; other site
1048245003706	H-loop/switch region; other site
1048245003709	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1048245003710	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
1048245003711	oligomer interface [polypeptide binding]; other site
1048245003712	metal binding site [ion binding]; metal-binding site
1048245003713	metal binding site [ion binding]; metal-binding site
1048245003714	putative Cl binding site [ion binding]; other site
1048245003715	basic sphincter; other site
1048245003716	hydrophobic gate; other site
1048245003717	periplasmic entrance; other site
1048245003718	malate dehydrogenase; Provisional; Region: PRK05442
1048245003719	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
1048245003720	NAD(P) binding site [chemical binding]; other site
1048245003721	dimer interface [polypeptide binding]; other site
1048245003722	malate binding site [chemical binding]; other site
1048245003724	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1048245003725	PE family; Region: PE; pfam00934
1048245003726	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1048245003728	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1048245003729	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245003730	NAD(P) binding site [chemical binding]; other site
1048245003731	active site
1048245003733	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1048245003734	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1048245003735	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
1048245003736	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1048245003737	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1048245003738	TPP-binding site [chemical binding]; other site
1048245003739	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1048245003740	dimer interface [polypeptide binding]; other site
1048245003741	PYR/PP interface [polypeptide binding]; other site
1048245003742	TPP binding site [chemical binding]; other site
1048245003743	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1048245003744	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245003745	putative substrate translocation pore; other site
1048245003746	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245003747	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
1048245003748	RNase_H superfamily; Region: RNase_H_2; pfam13482
1048245003749	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1048245003750	Part of AAA domain; Region: AAA_19; pfam13245
1048245003751	AAA domain; Region: AAA_12; pfam13087
1048245003753	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
1048245003754	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1048245003755	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1048245003756	ATP binding site [chemical binding]; other site
1048245003757	Mg++ binding site [ion binding]; other site
1048245003758	motif III; other site
1048245003759	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1048245003760	nucleotide binding region [chemical binding]; other site
1048245003761	ATP-binding site [chemical binding]; other site
1048245003762	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1048245003763	putative RNA binding site [nucleotide binding]; other site
1048245003766	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1048245003767	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245003768	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245003769	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245003771	FAD binding domain; Region: FAD_binding_4; pfam01565
1048245003772	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1048245003773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245003774	H+ Antiporter protein; Region: 2A0121; TIGR00900
1048245003775	putative substrate translocation pore; other site
1048245003777	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
1048245003778	Fe-S cluster binding site [ion binding]; other site
1048245003779	DNA binding site [nucleotide binding]
1048245003780	active site
1048245003781	hypothetical protein; Validated; Region: PRK05868
1048245003782	hypothetical protein; Provisional; Region: PRK07236
1048245003783	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1048245003784	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1048245003785	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1048245003786	HIT family signature motif; other site
1048245003787	catalytic residue [active]
1048245003789	amidase; Provisional; Region: PRK12470
1048245003790	Amidase; Region: Amidase; pfam01425
1048245003792	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1048245003793	cyclase homology domain; Region: CHD; cd07302
1048245003794	nucleotidyl binding site; other site
1048245003795	metal binding site [ion binding]; metal-binding site
1048245003796	dimer interface [polypeptide binding]; other site
1048245003797	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1048245003798	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1048245003799	active site
1048245003800	ATP binding site [chemical binding]; other site
1048245003801	substrate binding site [chemical binding]; other site
1048245003802	activation loop (A-loop); other site
1048245003803	PknH-like extracellular domain; Region: PknH_C; pfam14032
1048245003804	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1048245003805	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1048245003806	phosphopeptide binding site; other site
1048245003807	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1048245003808	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1048245003809	phosphopeptide binding site; other site
1048245003810	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
1048245003811	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1048245003812	Walker A/P-loop; other site
1048245003813	ATP binding site [chemical binding]; other site
1048245003814	Q-loop/lid; other site
1048245003815	ABC transporter signature motif; other site
1048245003816	Walker B; other site
1048245003817	D-loop; other site
1048245003818	H-loop/switch region; other site
1048245003819	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1048245003820	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1048245003821	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1048245003822	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1048245003823	active site
1048245003824	ATP binding site [chemical binding]; other site
1048245003825	substrate binding site [chemical binding]; other site
1048245003826	activation loop (A-loop); other site
1048245003828	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
1048245003829	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
1048245003830	DNA binding site [nucleotide binding]
1048245003831	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1048245003832	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1048245003833	phosphopeptide binding site; other site
1048245003834	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1048245003835	putative active site [active]
1048245003836	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
1048245003837	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
1048245003838	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1048245003839	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1048245003840	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1048245003841	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1048245003842	Walker A/P-loop; other site
1048245003843	ATP binding site [chemical binding]; other site
1048245003844	Q-loop/lid; other site
1048245003845	ABC transporter signature motif; other site
1048245003846	Walker B; other site
1048245003847	D-loop; other site
1048245003848	H-loop/switch region; other site
1048245003851	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1048245003852	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1048245003853	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1048245003854	Walker A/P-loop; other site
1048245003855	ATP binding site [chemical binding]; other site
1048245003856	Q-loop/lid; other site
1048245003857	ABC transporter signature motif; other site
1048245003858	Walker B; other site
1048245003859	D-loop; other site
1048245003860	H-loop/switch region; other site
1048245003865	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1048245003866	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1048245003867	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1048245003868	catalytic core [active]
1048245003869	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1048245003870	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1048245003871	active site
1048245003872	metal binding site [ion binding]; metal-binding site
1048245003873	DNA binding site [nucleotide binding]
1048245003874	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1048245003875	Walker A/P-loop; other site
1048245003876	ATP binding site [chemical binding]; other site
1048245003878	choline dehydrogenase; Validated; Region: PRK02106
1048245003879	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1048245003880	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1048245003883	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1048245003884	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1048245003885	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
1048245003886	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1048245003887	Walker A/P-loop; other site
1048245003888	ATP binding site [chemical binding]; other site
1048245003889	Q-loop/lid; other site
1048245003890	ABC transporter signature motif; other site
1048245003891	Walker B; other site
1048245003892	D-loop; other site
1048245003893	H-loop/switch region; other site
1048245003894	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1048245003895	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1048245003896	Walker A/P-loop; other site
1048245003897	ATP binding site [chemical binding]; other site
1048245003898	Q-loop/lid; other site
1048245003899	ABC transporter signature motif; other site
1048245003900	Walker B; other site
1048245003901	D-loop; other site
1048245003902	H-loop/switch region; other site
1048245003903	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1048245003908	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1048245003909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245003910	dimer interface [polypeptide binding]; other site
1048245003911	conserved gate region; other site
1048245003912	putative PBP binding loops; other site
1048245003913	ABC-ATPase subunit interface; other site
1048245003914	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1048245003915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245003916	dimer interface [polypeptide binding]; other site
1048245003917	conserved gate region; other site
1048245003918	putative PBP binding loops; other site
1048245003919	ABC-ATPase subunit interface; other site
1048245003921	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1048245003922	active site clefts [active]
1048245003923	zinc binding site [ion binding]; other site
1048245003924	dimer interface [polypeptide binding]; other site
1048245003925	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1048245003926	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1048245003927	Active Sites [active]
1048245003928	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
1048245003929	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1048245003930	CysD dimerization site [polypeptide binding]; other site
1048245003931	G1 box; other site
1048245003932	putative GEF interaction site [polypeptide binding]; other site
1048245003933	GTP/Mg2+ binding site [chemical binding]; other site
1048245003934	Switch I region; other site
1048245003935	G2 box; other site
1048245003936	G3 box; other site
1048245003937	Switch II region; other site
1048245003938	G4 box; other site
1048245003939	G5 box; other site
1048245003940	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1048245003941	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1048245003942	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1048245003943	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1048245003944	Walker A/P-loop; other site
1048245003945	ligand-binding site [chemical binding]; other site
1048245003946	ATP binding site [chemical binding]; other site
1048245003950	Rrf2 family protein; Region: rrf2_super; TIGR00738
1048245003951	Transcriptional regulator; Region: Rrf2; pfam02082
1048245003952	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1048245003953	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1048245003954	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1048245003955	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1048245003956	Putative esterase; Region: Esterase; pfam00756
1048245003957	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1048245003958	Predicted membrane protein [Function unknown]; Region: COG4325
1048245003959	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
1048245003960	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1048245003961	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1048245003962	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1048245003963	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1048245003964	active site
1048245003965	HIGH motif; other site
1048245003966	KMSK motif region; other site
1048245003967	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1048245003968	tRNA binding surface [nucleotide binding]; other site
1048245003969	anticodon binding site; other site
1048245003971	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1048245003972	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1048245003973	active site
1048245003974	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1048245003975	substrate binding site [chemical binding]; other site
1048245003976	catalytic residues [active]
1048245003977	dimer interface [polypeptide binding]; other site
1048245003980	homoserine dehydrogenase; Provisional; Region: PRK06349
1048245003981	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1048245003982	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1048245003983	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1048245003986	threonine synthase; Reviewed; Region: PRK06721
1048245003987	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1048245003988	homodimer interface [polypeptide binding]; other site
1048245003989	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245003990	catalytic residue [active]
1048245003992	Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083
1048245003995	transcription termination factor Rho; Provisional; Region: PRK12678
1048245003996	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1048245003997	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1048245003998	RNA binding site [nucleotide binding]; other site
1048245003999	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1048245004000	multimer interface [polypeptide binding]; other site
1048245004001	Walker A motif; other site
1048245004002	ATP binding site [chemical binding]; other site
1048245004003	Walker B motif; other site
1048245004004	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1048245004006	peptide chain release factor 1; Region: prfA; TIGR00019
1048245004007	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1048245004008	RF-1 domain; Region: RF-1; pfam00472
1048245004010	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1048245004011	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245004012	S-adenosylmethionine binding site [chemical binding]; other site
1048245004013	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1048245004015	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1048245004016	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1048245004017	Mg++ binding site [ion binding]; other site
1048245004018	putative catalytic motif [active]
1048245004019	substrate binding site [chemical binding]; other site
1048245004020	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1048245004021	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1048245004023	F0F1 ATP synthase subunit C; Validated; Region: PRK05880
1048245004025	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1048245004026	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1048245004027	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428
1048245004028	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1048245004029	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
1048245004030	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1048245004031	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1048245004032	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1048245004033	Walker A motif; other site
1048245004034	ATP binding site [chemical binding]; other site
1048245004035	Walker B motif; other site
1048245004036	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1048245004039	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1048245004040	core domain interface [polypeptide binding]; other site
1048245004041	delta subunit interface [polypeptide binding]; other site
1048245004042	epsilon subunit interface [polypeptide binding]; other site
1048245004044	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1048245004045	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1048245004046	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1048245004047	alpha subunit interaction interface [polypeptide binding]; other site
1048245004048	Walker A motif; other site
1048245004049	ATP binding site [chemical binding]; other site
1048245004050	Walker B motif; other site
1048245004051	inhibitor binding site; inhibition site
1048245004052	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1048245004055	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1048245004056	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1048245004057	gamma subunit interface [polypeptide binding]; other site
1048245004058	epsilon subunit interface [polypeptide binding]; other site
1048245004059	LBP interface [polypeptide binding]; other site
1048245004060	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
1048245004061	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
1048245004062	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1048245004063	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1048245004064	hinge; other site
1048245004065	active site
1048245004066	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
1048245004067	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1048245004068	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1048245004069	DNA binding site [nucleotide binding]
1048245004070	active site
1048245004072	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1048245004073	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1048245004074	AlkA N-terminal domain; Region: AlkA_N; pfam06029
1048245004075	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1048245004076	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1048245004077	minor groove reading motif; other site
1048245004078	helix-hairpin-helix signature motif; other site
1048245004079	substrate binding pocket [chemical binding]; other site
1048245004080	active site
1048245004082	HAMP domain; Region: HAMP; pfam00672
1048245004083	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1048245004084	cyclase homology domain; Region: CHD; cd07302
1048245004085	nucleotidyl binding site; other site
1048245004086	metal binding site [ion binding]; metal-binding site
1048245004087	dimer interface [polypeptide binding]; other site
1048245004088	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1048245004089	dimerization interface [polypeptide binding]; other site
1048245004090	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1048245004091	cyclase homology domain; Region: CHD; cd07302
1048245004092	nucleotidyl binding site; other site
1048245004093	metal binding site [ion binding]; metal-binding site
1048245004094	dimer interface [polypeptide binding]; other site
1048245004095	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1048245004096	dimerization interface [polypeptide binding]; other site
1048245004097	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1048245004098	cyclase homology domain; Region: CHD; cd07302
1048245004099	nucleotidyl binding site; other site
1048245004100	metal binding site [ion binding]; metal-binding site
1048245004101	dimer interface [polypeptide binding]; other site
1048245004102	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1048245004103	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1048245004104	dimerization interface [polypeptide binding]; other site
1048245004105	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1048245004106	cyclase homology domain; Region: CHD; cd07302
1048245004107	nucleotidyl binding site; other site
1048245004108	metal binding site [ion binding]; metal-binding site
1048245004109	dimer interface [polypeptide binding]; other site
1048245004110	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
1048245004111	hypothetical protein; Provisional; Region: PRK03298
1048245004112	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1048245004113	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1048245004114	dimer interface [polypeptide binding]; other site
1048245004115	substrate binding site [chemical binding]; other site
1048245004116	metal binding site [ion binding]; metal-binding site
1048245004117	putative acyltransferase; Provisional; Region: PRK05790
1048245004118	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1048245004119	dimer interface [polypeptide binding]; other site
1048245004120	active site
1048245004124	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1048245004125	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
1048245004127	PE family; Region: PE; pfam00934
1048245004128	glycogen branching enzyme; Provisional; Region: PRK05402
1048245004129	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1048245004130	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1048245004131	active site
1048245004132	catalytic site [active]
1048245004133	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1048245004134	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
1048245004135	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
1048245004136	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1048245004137	active site
1048245004138	homodimer interface [polypeptide binding]; other site
1048245004139	catalytic site [active]
1048245004140	acceptor binding site [chemical binding]; other site
1048245004141	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
1048245004142	putative homodimer interface [polypeptide binding]; other site
1048245004143	putative active site pocket [active]
1048245004144	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
1048245004145	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1048245004146	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1048245004147	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1048245004148	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1048245004150	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1048245004151	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1048245004152	active site
1048245004153	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
1048245004155	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
1048245004156	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
1048245004157	putative active site pocket [active]
1048245004158	cleavage site
1048245004159	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
1048245004160	MPN+ (JAMM) motif; other site
1048245004161	Zinc-binding site [ion binding]; other site
1048245004162	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1048245004163	MoaE interaction surface [polypeptide binding]; other site
1048245004164	MoeB interaction surface [polypeptide binding]; other site
1048245004165	thiocarboxylated glycine; other site
1048245004166	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1048245004167	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1048245004168	dimer interface [polypeptide binding]; other site
1048245004169	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245004170	catalytic residue [active]
1048245004172	Rhomboid family; Region: Rhomboid; pfam01694
1048245004173	glutamate racemase; Provisional; Region: PRK00865
1048245004175	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1048245004176	ribonuclease PH; Reviewed; Region: rph; PRK00173
1048245004177	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1048245004178	hexamer interface [polypeptide binding]; other site
1048245004179	active site
1048245004180	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1048245004181	active site
1048245004182	dimerization interface [polypeptide binding]; other site
1048245004183	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1048245004184	Glucitol operon activator [Transcription]; Region: GutM; COG4578
1048245004185	acyl carrier protein; Validated; Region: PRK05883
1048245004186	long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851
1048245004187	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1048245004188	acyl-activating enzyme (AAE) consensus motif; other site
1048245004189	active site
1048245004190	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245004191	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245004192	active site
1048245004193	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1048245004194	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
1048245004195	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1048245004196	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1048245004197	FAD binding pocket [chemical binding]; other site
1048245004198	FAD binding motif [chemical binding]; other site
1048245004199	phosphate binding motif [ion binding]; other site
1048245004200	NAD binding pocket [chemical binding]; other site
1048245004201	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1048245004202	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1048245004203	Walker A/P-loop; other site
1048245004204	ATP binding site [chemical binding]; other site
1048245004205	Q-loop/lid; other site
1048245004206	ABC transporter signature motif; other site
1048245004207	Walker B; other site
1048245004208	D-loop; other site
1048245004209	H-loop/switch region; other site
1048245004212	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1048245004213	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1048245004214	Walker A/P-loop; other site
1048245004215	ATP binding site [chemical binding]; other site
1048245004216	Q-loop/lid; other site
1048245004217	ABC transporter signature motif; other site
1048245004218	Walker B; other site
1048245004219	D-loop; other site
1048245004220	H-loop/switch region; other site
1048245004223	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1048245004224	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245004225	NAD(P) binding site [chemical binding]; other site
1048245004226	active site
1048245004228	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1048245004229	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245004230	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1048245004231	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1048245004232	GAF domain; Region: GAF; pfam01590
1048245004233	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1048245004234	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1048245004235	metal binding site [ion binding]; metal-binding site
1048245004236	active site
1048245004237	I-site; other site
1048245004238	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1048245004239	hypothetical protein; Provisional; Region: PRK07877
1048245004240	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
1048245004241	ATP binding site [chemical binding]; other site
1048245004242	substrate interface [chemical binding]; other site
1048245004243	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1048245004244	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1048245004245	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1048245004246	cyclase homology domain; Region: CHD; cd07302
1048245004247	nucleotidyl binding site; other site
1048245004248	dimer interface [polypeptide binding]; other site
1048245004249	metal binding site [ion binding]; metal-binding site
1048245004250	AAA ATPase domain; Region: AAA_16; pfam13191
1048245004251	Predicted ATPase [General function prediction only]; Region: COG3903
1048245004252	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1048245004253	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1048245004254	DNA binding residues [nucleotide binding]
1048245004255	dimerization interface [polypeptide binding]; other site
1048245004258	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1048245004259	cyclase homology domain; Region: CHD; cd07302
1048245004260	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
1048245004261	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1048245004262	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245004263	PPE family; Region: PPE; pfam00823
1048245004264	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245004266	PAS fold; Region: PAS_4; pfam08448
1048245004267	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1048245004268	putative active site [active]
1048245004269	heme pocket [chemical binding]; other site
1048245004270	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1048245004271	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1048245004272	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1048245004273	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1048245004274	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1048245004275	anti sigma factor interaction site; other site
1048245004276	regulatory phosphorylation site [posttranslational modification]; other site
1048245004277	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1048245004278	anti sigma factor interaction site; other site
1048245004279	regulatory phosphorylation site [posttranslational modification]; other site
1048245004280	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1048245004281	synthetase active site [active]
1048245004282	NTP binding site [chemical binding]; other site
1048245004283	metal binding site [ion binding]; metal-binding site
1048245004284	Beta-lactamase; Region: Beta-lactamase; pfam00144
1048245004285	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1048245004286	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
1048245004287	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173
1048245004288	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1048245004289	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
1048245004290	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
1048245004291	malonyl-CoA binding site [chemical binding]; other site
1048245004292	dimer interface [polypeptide binding]; other site
1048245004293	active site
1048245004294	product binding site; other site
1048245004295	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
1048245004296	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1048245004297	uncharacterized domain; Region: TIGR00702
1048245004298	YcaO-like family; Region: YcaO; pfam02624
1048245004299	Uncharacterized conserved protein [Function unknown]; Region: COG3482
1048245004300	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245004301	S-adenosylmethionine binding site [chemical binding]; other site
1048245004302	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245004303	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245004304	active site
1048245004305	bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
1048245004306	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1048245004307	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1048245004308	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1048245004309	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1048245004311	dihydroorotase; Validated; Region: pyrC; PRK09357
1048245004312	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1048245004313	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1048245004314	active site
1048245004316	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1048245004317	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1048245004318	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1048245004319	catalytic site [active]
1048245004320	subunit interface [polypeptide binding]; other site
1048245004322	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1048245004323	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1048245004324	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1048245004325	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1048245004326	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1048245004327	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1048245004328	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1048245004329	IMP binding site; other site
1048245004330	dimer interface [polypeptide binding]; other site
1048245004331	interdomain contacts; other site
1048245004332	partial ornithine binding site; other site
1048245004336	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1048245004337	active site
1048245004338	dimer interface [polypeptide binding]; other site
1048245004340	PE family; Region: PE; pfam00934
1048245004341	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245004342	PPE family; Region: PPE; pfam00823
1048245004343	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1048245004344	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1048245004345	catalytic site [active]
1048245004346	G-X2-G-X-G-K; other site
1048245004349	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
1048245004350	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1048245004351	Flavoprotein; Region: Flavoprotein; pfam02441
1048245004352	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1048245004353	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1048245004354	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1048245004355	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1048245004356	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1048245004358	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1048245004359	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1048245004360	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245004361	Cytochrome P450; Region: p450; cl12078
1048245004363	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1048245004364	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1048245004365	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1048245004366	PE family; Region: PE; pfam00934
1048245004367	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1048245004368	oligomeric interface; other site
1048245004369	putative active site [active]
1048245004370	homodimer interface [polypeptide binding]; other site
1048245004371	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1048245004372	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1048245004373	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1048245004374	substrate binding pocket [chemical binding]; other site
1048245004375	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1048245004376	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1048245004377	substrate binding pocket [chemical binding]; other site
1048245004378	Predicted membrane protein [Function unknown]; Region: COG3714
1048245004379	primosome assembly protein PriA; Provisional; Region: PRK14873
1048245004380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245004381	S-adenosylmethionine binding site [chemical binding]; other site
1048245004382	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1048245004383	MarR family; Region: MarR; pfam01047
1048245004384	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245004385	S-adenosylmethionine binding site [chemical binding]; other site
1048245004386	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1048245004387	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1048245004388	putative active site [active]
1048245004389	substrate binding site [chemical binding]; other site
1048245004390	putative cosubstrate binding site; other site
1048245004391	catalytic site [active]
1048245004392	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1048245004393	substrate binding site [chemical binding]; other site
1048245004394	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
1048245004395	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
1048245004396	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
1048245004397	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1048245004398	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1048245004399	substrate binding site [chemical binding]; other site
1048245004400	hexamer interface [polypeptide binding]; other site
1048245004401	metal binding site [ion binding]; metal-binding site
1048245004404	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1048245004405	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1048245004406	catalytic motif [active]
1048245004407	Zn binding site [ion binding]; other site
1048245004408	RibD C-terminal domain; Region: RibD_C; pfam01872
1048245004410	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1048245004411	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245004412	putative substrate translocation pore; other site
1048245004414	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
1048245004415	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1048245004416	Lumazine binding domain; Region: Lum_binding; pfam00677
1048245004417	Lumazine binding domain; Region: Lum_binding; pfam00677
1048245004420	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1048245004421	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1048245004422	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1048245004423	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1048245004424	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1048245004425	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1048245004426	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1048245004427	dimerization interface [polypeptide binding]; other site
1048245004428	active site
1048245004429	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1048245004430	homopentamer interface [polypeptide binding]; other site
1048245004431	active site
1048245004432	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1048245004433	PknH-like extracellular domain; Region: PknH_C; pfam14032
1048245004434	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1048245004435	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1048245004436	putative sugar binding sites [chemical binding]; other site
1048245004437	Q-X-W motif; other site
1048245004438	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1048245004439	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1048245004440	GIY-YIG motif/motif A; other site
1048245004441	active site
1048245004442	catalytic site [active]
1048245004443	putative DNA binding site [nucleotide binding]; other site
1048245004444	metal binding site [ion binding]; metal-binding site
1048245004445	UvrB/uvrC motif; Region: UVR; pfam02151
1048245004446	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1048245004447	Helix-hairpin-helix motif; Region: HHH; pfam00633
1048245004448	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
1048245004449	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1048245004450	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1048245004451	phosphate binding site [ion binding]; other site
1048245004452	putative substrate binding pocket [chemical binding]; other site
1048245004453	dimer interface [polypeptide binding]; other site
1048245004454	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1048245004455	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1048245004457	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1048245004458	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1048245004459	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1048245004460	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1048245004461	acyl-CoA synthetase; Provisional; Region: PRK13382
1048245004462	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1048245004463	acyl-activating enzyme (AAE) consensus motif; other site
1048245004464	putative AMP binding site [chemical binding]; other site
1048245004465	putative active site [active]
1048245004466	putative CoA binding site [chemical binding]; other site
1048245004468	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1048245004469	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
1048245004470	putative acyl-acceptor binding pocket; other site
1048245004471	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1048245004472	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1048245004473	PE family; Region: PE; pfam00934
1048245004474	PE-PPE domain; Region: PE-PPE; pfam08237
1048245004475	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
1048245004476	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1048245004477	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1048245004478	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1048245004479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1048245004480	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1048245004481	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1048245004482	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1048245004483	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1048245004485	Phosphoglycerate kinase; Region: PGK; pfam00162
1048245004486	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1048245004487	substrate binding site [chemical binding]; other site
1048245004488	hinge regions; other site
1048245004489	ADP binding site [chemical binding]; other site
1048245004490	catalytic site [active]
1048245004492	triosephosphate isomerase; Provisional; Region: PRK14567
1048245004493	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1048245004494	substrate binding site [chemical binding]; other site
1048245004495	dimer interface [polypeptide binding]; other site
1048245004496	catalytic triad [active]
1048245004498	SnoaL-like domain; Region: SnoaL_2; pfam12680
1048245004499	Preprotein translocase SecG subunit; Region: SecG; cl09123
1048245004500	PE family; Region: PE; pfam00934
1048245004501	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
1048245004502	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
1048245004503	molybdopterin cofactor binding site [chemical binding]; other site
1048245004504	substrate binding site [chemical binding]; other site
1048245004505	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
1048245004506	molybdopterin cofactor binding site; other site
1048245004507	hydrophobic ligand binding site; other site
1048245004508	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1048245004509	Proteins of 100 residues with WXG; Region: WXG100; cl02005
1048245004510	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1048245004511	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1048245004512	putative active site [active]
1048245004513	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
1048245004514	Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429
1048245004515	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1048245004516	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1048245004517	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1048245004519	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
1048245004520	putative active site [active]
1048245004521	transaldolase; Provisional; Region: PRK03903
1048245004522	catalytic residue [active]
1048245004523	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1048245004524	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1048245004525	TPP-binding site [chemical binding]; other site
1048245004526	dimer interface [polypeptide binding]; other site
1048245004527	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1048245004528	PYR/PP interface [polypeptide binding]; other site
1048245004529	dimer interface [polypeptide binding]; other site
1048245004530	TPP binding site [chemical binding]; other site
1048245004532	PE family; Region: PE; pfam00934
1048245004533	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1048245004534	UbiA prenyltransferase family; Region: UbiA; pfam01040
1048245004535	PE family; Region: PE; pfam00934
1048245004536	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1048245004537	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1048245004538	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1048245004539	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1048245004540	NADP binding site [chemical binding]; other site
1048245004541	dimer interface [polypeptide binding]; other site
1048245004543	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1048245004544	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1048245004545	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1048245004546	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1048245004547	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1048245004548	Walker A/P-loop; other site
1048245004549	ATP binding site [chemical binding]; other site
1048245004550	Q-loop/lid; other site
1048245004551	ABC transporter signature motif; other site
1048245004552	Walker B; other site
1048245004553	D-loop; other site
1048245004554	H-loop/switch region; other site
1048245004557	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1048245004558	Predicted transcriptional regulator [Transcription]; Region: COG2345
1048245004559	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1048245004560	putative DNA binding site [nucleotide binding]; other site
1048245004561	putative Zn2+ binding site [ion binding]; other site
1048245004562	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1048245004563	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1048245004564	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1048245004565	protein-splicing catalytic site; other site
1048245004566	thioester formation/cholesterol transfer; other site
1048245004567	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
1048245004568	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
1048245004569	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1048245004570	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1048245004571	FeS assembly protein SufD; Region: sufD; TIGR01981
1048245004572	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1048245004573	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1048245004574	Walker A/P-loop; other site
1048245004575	ATP binding site [chemical binding]; other site
1048245004576	Q-loop/lid; other site
1048245004577	ABC transporter signature motif; other site
1048245004578	Walker B; other site
1048245004579	D-loop; other site
1048245004580	H-loop/switch region; other site
1048245004582	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1048245004583	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1048245004584	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1048245004585	catalytic residue [active]
1048245004587	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1048245004588	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1048245004589	trimerization site [polypeptide binding]; other site
1048245004590	active site
1048245004591	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1048245004592	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1048245004593	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1048245004594	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245004595	active site
1048245004596	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1048245004597	PE family; Region: PE; pfam00934
1048245004598	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1048245004599	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1048245004601	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1048245004602	catalytic residues [active]
1048245004603	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1048245004604	catalytic residues [active]
1048245004606	enoyl-CoA hydratase; Provisional; Region: PRK05864
1048245004607	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245004608	substrate binding site [chemical binding]; other site
1048245004609	oxyanion hole (OAH) forming residues; other site
1048245004610	trimer interface [polypeptide binding]; other site
1048245004612	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1048245004613	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1048245004614	Walker A/P-loop; other site
1048245004615	ATP binding site [chemical binding]; other site
1048245004616	Q-loop/lid; other site
1048245004617	ABC transporter signature motif; other site
1048245004618	Walker B; other site
1048245004619	D-loop; other site
1048245004620	H-loop/switch region; other site
1048245004621	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1048245004626	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245004627	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245004628	aconitate hydratase; Validated; Region: PRK09277
1048245004629	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1048245004630	substrate binding site [chemical binding]; other site
1048245004631	ligand binding site [chemical binding]; other site
1048245004632	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1048245004633	substrate binding site [chemical binding]; other site
1048245004634	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1048245004635	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1048245004636	NlpC/P60 family; Region: NLPC_P60; pfam00877
1048245004637	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1048245004638	NlpC/P60 family; Region: NLPC_P60; pfam00877
1048245004639	MoxR-like ATPases [General function prediction only]; Region: COG0714
1048245004640	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245004641	Walker A motif; other site
1048245004642	ATP binding site [chemical binding]; other site
1048245004643	Walker B motif; other site
1048245004644	arginine finger; other site
1048245004645	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1048245004646	Protein of unknown function DUF58; Region: DUF58; pfam01882
1048245004647	hypothetical protein; Provisional; Region: PRK13685
1048245004648	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1048245004649	metal ion-dependent adhesion site (MIDAS); other site
1048245004650	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1048245004651	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1048245004652	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1048245004653	NAD(P) binding site [chemical binding]; other site
1048245004654	homotetramer interface [polypeptide binding]; other site
1048245004655	homodimer interface [polypeptide binding]; other site
1048245004656	active site
1048245004658	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
1048245004659	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1048245004660	NAD binding site [chemical binding]; other site
1048245004661	homotetramer interface [polypeptide binding]; other site
1048245004662	homodimer interface [polypeptide binding]; other site
1048245004663	substrate binding site [chemical binding]; other site
1048245004664	active site
1048245004665	ferrochelatase; Reviewed; Region: hemH; PRK00035
1048245004666	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1048245004667	C-terminal domain interface [polypeptide binding]; other site
1048245004668	active site
1048245004669	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1048245004670	active site
1048245004671	N-terminal domain interface [polypeptide binding]; other site
1048245004672	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
1048245004673	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1048245004674	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1048245004675	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
1048245004676	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1048245004677	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1048245004678	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
1048245004679	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
1048245004680	heterodimer interface [polypeptide binding]; other site
1048245004681	substrate interaction site [chemical binding]; other site
1048245004682	Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185
1048245004685	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
1048245004686	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
1048245004687	active site
1048245004688	substrate binding site [chemical binding]; other site
1048245004689	coenzyme B12 binding site [chemical binding]; other site
1048245004690	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
1048245004691	B12 binding site [chemical binding]; other site
1048245004692	cobalt ligand [ion binding]; other site
1048245004694	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1048245004695	membrane ATPase/protein kinase; Provisional; Region: PRK09435
1048245004696	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
1048245004697	Walker A; other site
1048245004698	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1048245004699	Beta-lactamase; Region: Beta-lactamase; pfam00144
1048245004700	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1048245004701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245004702	S-adenosylmethionine binding site [chemical binding]; other site
1048245004704	Uncharacterized conserved protein [Function unknown]; Region: COG3360
1048245004705	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1048245004706	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1048245004707	Ligand binding site; other site
1048245004708	Putative Catalytic site; other site
1048245004709	DXD motif; other site
1048245004710	Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285
1048245004711	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
1048245004712	active site
1048245004713	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1048245004714	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1048245004715	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1048245004716	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1048245004717	inhibitor-cofactor binding pocket; inhibition site
1048245004718	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245004719	catalytic residue [active]
1048245004720	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1048245004721	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1048245004722	putative trimer interface [polypeptide binding]; other site
1048245004723	putative CoA binding site [chemical binding]; other site
1048245004724	Methyltransferase domain; Region: Methyltransf_12; pfam08242
1048245004725	S-adenosylmethionine binding site [chemical binding]; other site
1048245004726	WbqC-like protein family; Region: WbqC; pfam08889
1048245004727	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1048245004728	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245004729	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245004730	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1048245004731	Methyltransferase domain; Region: Methyltransf_12; pfam08242
1048245004732	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1048245004733	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1048245004734	NADP-binding site; other site
1048245004735	homotetramer interface [polypeptide binding]; other site
1048245004736	substrate binding site [chemical binding]; other site
1048245004737	homodimer interface [polypeptide binding]; other site
1048245004738	active site
1048245004739	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1048245004740	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1048245004741	NADP binding site [chemical binding]; other site
1048245004742	active site
1048245004743	putative substrate binding site [chemical binding]; other site
1048245004744	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1048245004745	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
1048245004746	metal-binding site
1048245004747	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245004748	S-adenosylmethionine binding site [chemical binding]; other site
1048245004749	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1048245004750	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1048245004751	active site
1048245004752	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
1048245004753	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1048245004754	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1048245004755	active site
1048245004756	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
1048245004757	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1048245004758	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1048245004759	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1048245004760	active site
1048245004761	acyl-CoA synthetase; Validated; Region: PRK05850
1048245004762	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1048245004763	acyl-activating enzyme (AAE) consensus motif; other site
1048245004764	active site
1048245004765	Transport protein; Region: actII; TIGR00833
1048245004766	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1048245004767	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245004768	S-adenosylmethionine binding site [chemical binding]; other site
1048245004769	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1048245004770	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1048245004771	homodimer interface [polypeptide binding]; other site
1048245004772	active site
1048245004773	TDP-binding site; other site
1048245004774	acceptor substrate-binding pocket; other site
1048245004775	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1048245004776	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1048245004777	Probable Catalytic site; other site
1048245004778	metal-binding site
1048245004779	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1048245004780	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1048245004781	homodimer interface [polypeptide binding]; other site
1048245004782	active site
1048245004783	TDP-binding site; other site
1048245004784	acceptor substrate-binding pocket; other site
1048245004785	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1048245004786	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245004787	active site
1048245004788	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
1048245004789	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1048245004790	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245004791	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1048245004792	Enoylreductase; Region: PKS_ER; smart00829
1048245004793	NAD(P) binding site [chemical binding]; other site
1048245004794	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1048245004795	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1048245004796	putative NADP binding site [chemical binding]; other site
1048245004797	active site
1048245004798	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245004799	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1048245004800	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245004801	active site
1048245004802	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
1048245004803	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1048245004804	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245004805	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1048245004806	Enoylreductase; Region: PKS_ER; smart00829
1048245004807	NAD(P) binding site [chemical binding]; other site
1048245004808	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1048245004809	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1048245004810	putative NADP binding site [chemical binding]; other site
1048245004811	active site
1048245004812	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245004813	acyl-CoA synthetase; Validated; Region: PRK05850
1048245004814	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1048245004815	acyl-activating enzyme (AAE) consensus motif; other site
1048245004816	active site
1048245004817	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1048245004818	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1048245004819	NAD(P) binding site [chemical binding]; other site
1048245004821	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1048245004822	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1048245004823	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1048245004824	CoenzymeA binding site [chemical binding]; other site
1048245004825	subunit interaction site [polypeptide binding]; other site
1048245004826	PHB binding site; other site
1048245004827	Nitronate monooxygenase; Region: NMO; pfam03060
1048245004828	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1048245004829	FMN binding site [chemical binding]; other site
1048245004830	substrate binding site [chemical binding]; other site
1048245004831	putative catalytic residue [active]
1048245004832	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245004834	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
1048245004835	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1048245004836	HIGH motif; other site
1048245004837	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1048245004838	active site
1048245004839	KMSKS motif; other site
1048245004840	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
1048245004841	tRNA binding surface [nucleotide binding]; other site
1048245004842	anticodon binding site; other site
1048245004844	DNA polymerase IV; Provisional; Region: PRK03348
1048245004845	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1048245004846	active site
1048245004847	DNA binding site [nucleotide binding]
1048245004848	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1048245004849	active site
1048245004850	homodimer interface [polypeptide binding]; other site
1048245004851	homotetramer interface [polypeptide binding]; other site
1048245004853	lipoprotein signal peptidase; Provisional; Region: PRK14764
1048245004854	lipoprotein signal peptidase; Provisional; Region: PRK14787
1048245004855	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1048245004856	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1048245004857	active site
1048245004859	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
1048245004860	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1048245004861	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
1048245004862	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1048245004863	apolar tunnel; other site
1048245004864	heme binding site [chemical binding]; other site
1048245004865	dimerization interface [polypeptide binding]; other site
1048245004866	short chain dehydrogenase; Provisional; Region: PRK05866
1048245004867	classical (c) SDRs; Region: SDR_c; cd05233
1048245004868	NAD(P) binding site [chemical binding]; other site
1048245004869	active site
1048245004870	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1048245004871	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245004872	NAD(P) binding site [chemical binding]; other site
1048245004873	active site
1048245004875	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1048245004876	hydrophobic ligand binding site; other site
1048245004877	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1048245004878	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1048245004879	active site
1048245004880	PHP Thumb interface [polypeptide binding]; other site
1048245004881	metal binding site [ion binding]; metal-binding site
1048245004882	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1048245004883	generic binding surface II; other site
1048245004884	generic binding surface I; other site
1048245004885	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245004886	PPE family; Region: PPE; pfam00823
1048245004887	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245004888	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245004889	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1048245004890	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1048245004891	acyl-activating enzyme (AAE) consensus motif; other site
1048245004892	putative AMP binding site [chemical binding]; other site
1048245004893	putative active site [active]
1048245004894	putative CoA binding site [chemical binding]; other site
1048245004896	glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915
1048245004897	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
1048245004898	putative acyl-acceptor binding pocket; other site
1048245004899	fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176
1048245004900	L-aspartate oxidase; Provisional; Region: PRK06175
1048245004901	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1048245004903	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
1048245004904	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1048245004906	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
1048245004907	Iron-sulfur protein interface; other site
1048245004908	proximal heme binding site [chemical binding]; other site
1048245004909	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
1048245004910	Iron-sulfur protein interface; other site
1048245004911	proximal quinone binding site [chemical binding]; other site
1048245004912	C-subunit interface; other site
1048245004913	distal quinone binding site; other site
1048245004914	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245004915	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245004916	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1048245004917	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1048245004918	threonine dehydratase; Validated; Region: PRK08639
1048245004919	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1048245004920	tetramer interface [polypeptide binding]; other site
1048245004921	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245004922	catalytic residue [active]
1048245004923	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
1048245004925	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1048245004926	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1048245004927	putative active site [active]
1048245004928	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1048245004929	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1048245004930	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
1048245004931	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
1048245004932	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
1048245004933	catalytic site [active]
1048245004934	active site
1048245004935	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1048245004936	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
1048245004937	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
1048245004938	active site
1048245004939	catalytic site [active]
1048245004940	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1048245004941	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1048245004942	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1048245004943	active site
1048245004944	catalytic site [active]
1048245004945	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1048245004946	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1048245004947	NlpC/P60 family; Region: NLPC_P60; pfam00877
1048245004948	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
1048245004949	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1048245004950	inhibitor-cofactor binding pocket; inhibition site
1048245004951	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245004952	catalytic residue [active]
1048245004954	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1048245004955	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1048245004956	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1048245004957	catalytic residue [active]
1048245004959	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1048245004960	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
1048245004961	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245004962	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245004963	active site
1048245004964	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245004965	biotin synthase; Validated; Region: PRK06256
1048245004966	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1048245004967	FeS/SAM binding site; other site
1048245004968	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1048245004969	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
1048245004970	Secretory lipase; Region: LIP; pfam03583
1048245004971	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
1048245004972	nudix motif; other site
1048245004973	quinolinate synthetase; Provisional; Region: PRK09375
1048245004974	L-aspartate oxidase; Provisional; Region: PRK07804
1048245004975	L-aspartate oxidase; Provisional; Region: PRK06175
1048245004976	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1048245004977	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
1048245004978	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1048245004979	dimerization interface [polypeptide binding]; other site
1048245004980	active site
1048245004981	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245004982	S-adenosylmethionine binding site [chemical binding]; other site
1048245004983	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
1048245004984	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
1048245004985	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1048245004986	NAD binding site [chemical binding]; other site
1048245004987	dimerization interface [polypeptide binding]; other site
1048245004988	product binding site; other site
1048245004989	substrate binding site [chemical binding]; other site
1048245004990	zinc binding site [ion binding]; other site
1048245004991	catalytic residues [active]
1048245004993	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
1048245004994	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1048245004995	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245004996	homodimer interface [polypeptide binding]; other site
1048245004997	catalytic residue [active]
1048245004999	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1048245005000	4-fold oligomerization interface [polypeptide binding]; other site
1048245005001	putative active site pocket [active]
1048245005002	metal binding residues [ion binding]; metal-binding site
1048245005003	3-fold/trimer interface [polypeptide binding]; other site
1048245005004	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1048245005005	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1048245005006	putative active site [active]
1048245005007	oxyanion strand; other site
1048245005008	catalytic triad [active]
1048245005010	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1048245005011	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1048245005012	catalytic residues [active]
1048245005013	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1048245005014	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1048245005015	active site
1048245005016	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1048245005017	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1048245005018	substrate binding site [chemical binding]; other site
1048245005019	glutamase interaction surface [polypeptide binding]; other site
1048245005020	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1048245005021	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
1048245005022	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1048245005023	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1048245005024	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1048245005025	catalytic triad [active]
1048245005026	anthranilate synthase component I; Provisional; Region: PRK13571
1048245005027	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1048245005028	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1048245005029	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
1048245005030	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1048245005031	active site
1048245005032	ribulose/triose binding site [chemical binding]; other site
1048245005033	phosphate binding site [ion binding]; other site
1048245005034	substrate (anthranilate) binding pocket [chemical binding]; other site
1048245005035	product (indole) binding pocket [chemical binding]; other site
1048245005037	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1048245005038	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1048245005039	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245005040	catalytic residue [active]
1048245005042	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1048245005043	substrate binding site [chemical binding]; other site
1048245005044	active site
1048245005045	catalytic residues [active]
1048245005046	heterodimer interface [polypeptide binding]; other site
1048245005047	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
1048245005048	Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682
1048245005049	TM2 domain; Region: TM2; pfam05154
1048245005050	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
1048245005052	pyruvate kinase; Provisional; Region: PRK06247
1048245005053	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1048245005054	domain interfaces; other site
1048245005055	active site
1048245005056	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1048245005057	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1048245005058	active site
1048245005059	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1048245005060	catalytic triad [active]
1048245005061	dimer interface [polypeptide binding]; other site
1048245005062	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1048245005063	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1048245005064	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
1048245005065	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1048245005066	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1048245005067	Walker A/P-loop; other site
1048245005068	Walker A/P-loop; other site
1048245005069	ATP binding site [chemical binding]; other site
1048245005070	ATP binding site [chemical binding]; other site
1048245005071	Q-loop/lid; other site
1048245005074	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1048245005075	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1048245005076	Walker A/P-loop; other site
1048245005077	ATP binding site [chemical binding]; other site
1048245005078	Q-loop/lid; other site
1048245005079	ABC transporter signature motif; other site
1048245005080	Walker B; other site
1048245005081	D-loop; other site
1048245005082	H-loop/switch region; other site
1048245005085	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1048245005086	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1048245005087	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1048245005088	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1048245005089	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1048245005090	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
1048245005091	cyclase homology domain; Region: CHD; cd07302
1048245005092	nucleotidyl binding site; other site
1048245005093	metal binding site [ion binding]; metal-binding site
1048245005094	dimer interface [polypeptide binding]; other site
1048245005095	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1048245005096	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1048245005097	active site
1048245005098	phosphorylation site [posttranslational modification]
1048245005099	intermolecular recognition site; other site
1048245005100	dimerization interface [polypeptide binding]; other site
1048245005101	ANTAR domain; Region: ANTAR; pfam03861
1048245005102	lipid-transfer protein; Provisional; Region: PRK06059
1048245005103	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1048245005104	active site
1048245005106	DNA polymerase I; Provisional; Region: PRK05755
1048245005107	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1048245005108	active site
1048245005109	metal binding site 1 [ion binding]; metal-binding site
1048245005110	putative 5' ssDNA interaction site; other site
1048245005111	metal binding site 3; metal-binding site
1048245005112	metal binding site 2 [ion binding]; metal-binding site
1048245005113	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1048245005114	putative DNA binding site [nucleotide binding]; other site
1048245005115	putative metal binding site [ion binding]; other site
1048245005116	3'-5' exonuclease; Region: 35EXOc; smart00474
1048245005117	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1048245005118	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1048245005119	active site
1048245005120	DNA binding site [nucleotide binding]
1048245005121	catalytic site [active]
1048245005123	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
1048245005124	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1048245005125	RNA binding site [nucleotide binding]; other site
1048245005126	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1048245005127	RNA binding site [nucleotide binding]; other site
1048245005128	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1048245005129	RNA binding site [nucleotide binding]; other site
1048245005130	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1048245005131	RNA binding site [nucleotide binding]; other site
1048245005132	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
1048245005133	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1048245005134	CoA-binding site [chemical binding]; other site
1048245005135	ATP-binding [chemical binding]; other site
1048245005136	Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320
1048245005138	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
1048245005139	excinuclease ABC subunit B; Provisional; Region: PRK05298
1048245005140	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1048245005141	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1048245005142	nucleotide binding region [chemical binding]; other site
1048245005143	ATP-binding site [chemical binding]; other site
1048245005144	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1048245005145	UvrB/uvrC motif; Region: UVR; pfam02151
1048245005147	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245005148	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1048245005149	putative substrate translocation pore; other site
1048245005150	Predicted membrane protein [Function unknown]; Region: COG5305
1048245005151	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1048245005152	Ligand Binding Site [chemical binding]; other site
1048245005153	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1048245005154	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1048245005155	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1048245005156	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1048245005157	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1048245005162	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1048245005163	Predicted esterase [General function prediction only]; Region: COG0627
1048245005165	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
1048245005166	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1048245005167	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1048245005168	dimer interface [polypeptide binding]; other site
1048245005169	putative anticodon binding site; other site
1048245005170	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1048245005171	motif 1; other site
1048245005172	dimer interface [polypeptide binding]; other site
1048245005173	active site
1048245005174	motif 2; other site
1048245005175	motif 3; other site
1048245005178	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1048245005179	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1048245005180	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1048245005181	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1048245005182	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1048245005183	23S rRNA binding site [nucleotide binding]; other site
1048245005184	L21 binding site [polypeptide binding]; other site
1048245005185	L13 binding site [polypeptide binding]; other site
1048245005187	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1048245005188	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1048245005189	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
1048245005190	PE family; Region: PE; pfam00934
1048245005191	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1048245005192	cyclase homology domain; Region: CHD; cd07302
1048245005193	nucleotidyl binding site; other site
1048245005194	metal binding site [ion binding]; metal-binding site
1048245005195	dimer interface [polypeptide binding]; other site
1048245005196	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1048245005197	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1048245005198	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1048245005199	dimer interface [polypeptide binding]; other site
1048245005200	motif 1; other site
1048245005201	active site
1048245005202	motif 2; other site
1048245005203	motif 3; other site
1048245005205	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1048245005206	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1048245005207	putative tRNA-binding site [nucleotide binding]; other site
1048245005208	B3/4 domain; Region: B3_4; pfam03483
1048245005209	tRNA synthetase B5 domain; Region: B5; smart00874
1048245005210	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1048245005211	dimer interface [polypeptide binding]; other site
1048245005212	motif 1; other site
1048245005213	motif 3; other site
1048245005214	motif 2; other site
1048245005215	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1048245005216	PE family; Region: PE; pfam00934
1048245005217	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
1048245005218	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1048245005219	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1048245005220	heterotetramer interface [polypeptide binding]; other site
1048245005221	active site pocket [active]
1048245005222	cleavage site
1048245005223	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1048245005224	feedback inhibition sensing region; other site
1048245005225	homohexameric interface [polypeptide binding]; other site
1048245005226	nucleotide binding site [chemical binding]; other site
1048245005227	N-acetyl-L-glutamate binding site [chemical binding]; other site
1048245005228	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
1048245005229	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1048245005230	inhibitor-cofactor binding pocket; inhibition site
1048245005231	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245005232	catalytic residue [active]
1048245005234	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1048245005235	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1048245005236	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1048245005238	arginine repressor; Region: argR_whole; TIGR01529
1048245005239	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1048245005240	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1048245005241	argininosuccinate synthase; Provisional; Region: PRK13820
1048245005242	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1048245005243	ANP binding site [chemical binding]; other site
1048245005244	Substrate Binding Site II [chemical binding]; other site
1048245005245	Substrate Binding Site I [chemical binding]; other site
1048245005248	argininosuccinate lyase; Provisional; Region: PRK00855
1048245005249	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1048245005250	active sites [active]
1048245005251	tetramer interface [polypeptide binding]; other site
1048245005254	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
1048245005255	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
1048245005256	malonyl-CoA binding site [chemical binding]; other site
1048245005257	dimer interface [polypeptide binding]; other site
1048245005258	active site
1048245005259	product binding site; other site
1048245005260	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1048245005261	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245005262	active site
1048245005263	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1048245005264	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1048245005265	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245005266	Enoylreductase; Region: PKS_ER; smart00829
1048245005267	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1048245005268	NAD(P) binding site [chemical binding]; other site
1048245005269	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
1048245005270	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1048245005271	putative NADP binding site [chemical binding]; other site
1048245005272	active site
1048245005273	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245005277	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1048245005278	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245005279	active site
1048245005280	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1048245005281	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1048245005282	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245005283	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1048245005284	Enoylreductase; Region: PKS_ER; smart00829
1048245005285	NAD(P) binding site [chemical binding]; other site
1048245005286	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
1048245005287	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1048245005288	putative NADP binding site [chemical binding]; other site
1048245005289	active site
1048245005290	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245005294	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1048245005295	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245005296	active site
1048245005297	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1048245005298	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1048245005299	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245005301	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
1048245005302	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
1048245005303	malonyl-CoA binding site [chemical binding]; other site
1048245005304	dimer interface [polypeptide binding]; other site
1048245005305	active site
1048245005306	product binding site; other site
1048245005307	Cytochrome P450; Region: p450; cl12078
1048245005308	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245005310	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1048245005311	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1048245005312	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1048245005313	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1048245005314	ABC transporter; Region: ABC_tran_2; pfam12848
1048245005315	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1048245005320	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1048245005321	MULE transposase domain; Region: MULE; pfam10551
1048245005322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
1048245005323	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245005324	putative substrate translocation pore; other site
1048245005325	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1048245005326	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1048245005327	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1048245005328	dimerization interface [polypeptide binding]; other site
1048245005329	putative DNA binding site [nucleotide binding]; other site
1048245005330	putative Zn2+ binding site [ion binding]; other site
1048245005331	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1048245005332	active site residue [active]
1048245005334	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1048245005335	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1048245005336	ligand binding site [chemical binding]; other site
1048245005337	flexible hinge region; other site
1048245005338	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1048245005339	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
1048245005340	putative catalytic residues [active]
1048245005341	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
1048245005342	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1048245005343	catalytic residues [active]
1048245005346	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245005347	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245005348	active site
1048245005349	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1048245005350	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1048245005351	substrate binding pocket [chemical binding]; other site
1048245005352	membrane-bound complex binding site; other site
1048245005353	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1048245005354	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1048245005355	FeS/SAM binding site; other site
1048245005356	DivIVA protein; Region: DivIVA; pfam05103
1048245005357	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1048245005358	acyl-CoA synthetase; Validated; Region: PRK07868
1048245005359	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
1048245005360	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245005361	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245005362	acyl-activating enzyme (AAE) consensus motif; other site
1048245005363	AMP binding site [chemical binding]; other site
1048245005364	active site
1048245005365	CoA binding site [chemical binding]; other site
1048245005367	Uncharacterized conserved protein [Function unknown]; Region: COG2835
1048245005368	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245005369	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245005370	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
1048245005371	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1048245005372	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1048245005373	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
1048245005374	Walker A/P-loop; other site
1048245005375	ATP binding site [chemical binding]; other site
1048245005376	Q-loop/lid; other site
1048245005377	ABC transporter signature motif; other site
1048245005378	Walker B; other site
1048245005379	D-loop; other site
1048245005380	H-loop/switch region; other site
1048245005384	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1048245005385	active site
1048245005386	DNA binding site [nucleotide binding]
1048245005387	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1048245005388	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1048245005389	active site
1048245005390	HIGH motif; other site
1048245005391	dimer interface [polypeptide binding]; other site
1048245005392	KMSKS motif; other site
1048245005393	S4 RNA-binding domain; Region: S4; smart00363
1048245005394	RNA binding surface [nucleotide binding]; other site
1048245005396	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1048245005398	Tetratrico peptide repeat; Region: TPR_5; pfam12688
1048245005399	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1048245005400	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
1048245005401	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1048245005402	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1048245005403	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1048245005404	RNA binding surface [nucleotide binding]; other site
1048245005405	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245005406	S-adenosylmethionine binding site [chemical binding]; other site
1048245005407	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
1048245005408	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1048245005409	DNA repair protein RecN; Region: recN; TIGR00634
1048245005410	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1048245005411	Walker A/P-loop; other site
1048245005412	ATP binding site [chemical binding]; other site
1048245005413	Q-loop/lid; other site
1048245005414	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1048245005415	ABC transporter signature motif; other site
1048245005416	Walker B; other site
1048245005417	D-loop; other site
1048245005418	H-loop/switch region; other site
1048245005420	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
1048245005421	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
1048245005422	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
1048245005423	CTP synthetase; Validated; Region: pyrG; PRK05380
1048245005424	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1048245005425	Catalytic site [active]
1048245005426	active site
1048245005427	UTP binding site [chemical binding]; other site
1048245005428	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1048245005429	active site
1048245005430	putative oxyanion hole; other site
1048245005431	catalytic triad [active]
1048245005433	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1048245005434	dimer interface [polypeptide binding]; other site
1048245005435	ADP-ribose binding site [chemical binding]; other site
1048245005436	active site
1048245005437	nudix motif; other site
1048245005438	metal binding site [ion binding]; metal-binding site
1048245005439	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1048245005440	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1048245005441	active site
1048245005442	DNA binding site [nucleotide binding]
1048245005443	Int/Topo IB signature motif; other site
1048245005444	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1048245005445	MULE transposase domain; Region: MULE; pfam10551
1048245005446	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245005447	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245005448	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1048245005449	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245005450	S-adenosylmethionine binding site [chemical binding]; other site
1048245005451	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1048245005453	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245005454	PPE family; Region: PPE; pfam00823
1048245005455	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245005456	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245005457	PPE family; Region: PPE; pfam00823
1048245005458	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245005459	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1048245005460	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1048245005461	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1048245005462	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1048245005463	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1048245005464	P-loop; other site
1048245005465	Magnesium ion binding site [ion binding]; other site
1048245005466	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1048245005467	Magnesium ion binding site [ion binding]; other site
1048245005468	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1048245005469	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
1048245005470	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1048245005471	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1048245005472	RNA binding surface [nucleotide binding]; other site
1048245005473	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1048245005474	active site
1048245005476	cytidylate kinase; Provisional; Region: cmk; PRK00023
1048245005477	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1048245005478	CMP-binding site; other site
1048245005479	The sites determining sugar specificity; other site
1048245005481	GTP-binding protein Der; Reviewed; Region: PRK03003
1048245005482	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1048245005483	GTP/Mg2+ binding site [chemical binding]; other site
1048245005484	Switch I region; other site
1048245005485	G2 box; other site
1048245005486	Switch II region; other site
1048245005487	G3 box; other site
1048245005488	G4 box; other site
1048245005489	G5 box; other site
1048245005490	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1048245005491	G1 box; other site
1048245005492	GTP/Mg2+ binding site [chemical binding]; other site
1048245005493	Switch I region; other site
1048245005494	G2 box; other site
1048245005495	G3 box; other site
1048245005496	Switch II region; other site
1048245005497	G4 box; other site
1048245005498	G5 box; other site
1048245005501	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1048245005502	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1048245005503	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1048245005504	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1048245005505	Cupin domain; Region: Cupin_2; pfam07883
1048245005506	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1048245005507	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1048245005508	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1048245005509	putative switch regulator; other site
1048245005510	non-specific DNA interactions [nucleotide binding]; other site
1048245005511	DNA binding site [nucleotide binding]
1048245005512	sequence specific DNA binding site [nucleotide binding]; other site
1048245005513	putative cAMP binding site [chemical binding]; other site
1048245005514	Bacterial transcriptional regulator; Region: IclR; pfam01614
1048245005515	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
1048245005516	putative active site [active]
1048245005517	homotetrameric interface [polypeptide binding]; other site
1048245005518	metal binding site [ion binding]; metal-binding site
1048245005520	biotin carboxylase-like protein; Validated; Region: PRK06524
1048245005521	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1048245005523	Predicted transcriptional regulators [Transcription]; Region: COG1733
1048245005524	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1048245005525	dimerization interface [polypeptide binding]; other site
1048245005526	putative DNA binding site [nucleotide binding]; other site
1048245005527	putative Zn2+ binding site [ion binding]; other site
1048245005528	Predicted transcriptional regulators [Transcription]; Region: COG1733
1048245005529	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1048245005530	FAD binding domain; Region: FAD_binding_4; pfam01565
1048245005531	Berberine and berberine like; Region: BBE; pfam08031
1048245005532	TIGR03086 family protein; Region: TIGR03086
1048245005533	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1048245005534	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1048245005535	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1048245005536	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1048245005537	Beta-lactamase; Region: Beta-lactamase; pfam00144
1048245005538	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
1048245005539	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
1048245005540	NAD(P) binding site [chemical binding]; other site
1048245005541	catalytic residues [active]
1048245005544	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
1048245005545	putative catalytic residue [active]
1048245005546	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
1048245005547	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1048245005548	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
1048245005549	gating phenylalanine in ion channel; other site
1048245005550	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1048245005551	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
1048245005552	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1048245005553	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1048245005554	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1048245005555	[4Fe-4S] binding site [ion binding]; other site
1048245005556	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1048245005557	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1048245005558	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1048245005559	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1048245005560	molybdopterin cofactor binding site; other site
1048245005562	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245005563	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
1048245005564	putative substrate translocation pore; other site
1048245005565	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
1048245005566	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1048245005567	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1048245005568	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1048245005569	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1048245005571	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
1048245005572	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742
1048245005573	putative active site [active]
1048245005574	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
1048245005575	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1048245005576	active site
1048245005577	ATP binding site [chemical binding]; other site
1048245005578	substrate binding site [chemical binding]; other site
1048245005579	activation loop (A-loop); other site
1048245005580	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1048245005581	Thioredoxin; Region: Thioredoxin_4; cl17273
1048245005583	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
1048245005584	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
1048245005585	active site
1048245005586	metal binding site [ion binding]; metal-binding site
1048245005587	nudix motif; other site
1048245005588	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1048245005589	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1048245005590	active site
1048245005591	ATP binding site [chemical binding]; other site
1048245005592	substrate binding site [chemical binding]; other site
1048245005593	activation loop (A-loop); other site
1048245005595	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1048245005596	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1048245005597	phosphopeptide binding site; other site
1048245005598	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1048245005599	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1048245005600	phosphopeptide binding site; other site
1048245005601	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
1048245005602	The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955
1048245005603	Walker A/P-loop; other site
1048245005604	ATP binding site [chemical binding]; other site
1048245005605	Q-loop/lid; other site
1048245005606	ABC transporter signature motif; other site
1048245005607	Walker B; other site
1048245005608	D-loop; other site
1048245005609	H-loop/switch region; other site
1048245005610	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1048245005613	acyl-CoA synthetase; Provisional; Region: PRK13388
1048245005614	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245005615	acyl-activating enzyme (AAE) consensus motif; other site
1048245005616	AMP binding site [chemical binding]; other site
1048245005617	active site
1048245005618	CoA binding site [chemical binding]; other site
1048245005620	hypothetical protein; Provisional; Region: PRK06185
1048245005621	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1048245005622	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1048245005624	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1048245005625	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245005626	PPE family; Region: PPE; pfam00823
1048245005627	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245005628	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245005629	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
1048245005631	putative transposase OrfB; Reviewed; Region: PHA02517
1048245005632	HTH-like domain; Region: HTH_21; pfam13276
1048245005633	Integrase core domain; Region: rve; pfam00665
1048245005634	Integrase core domain; Region: rve_3; pfam13683
1048245005635	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
1048245005636	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1048245005637	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1048245005638	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1048245005639	sulfite oxidase; Provisional; Region: PLN00177
1048245005640	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
1048245005641	Moco binding site; other site
1048245005642	metal coordination site [ion binding]; other site
1048245005643	dimerization interface [polypeptide binding]; other site
1048245005644	Transport protein; Region: actII; TIGR00833
1048245005645	Cutinase; Region: Cutinase; pfam01083
1048245005646	PE family; Region: PE; pfam00934
1048245005647	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1048245005648	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1048245005649	Uncharacterized conserved protein [Function unknown]; Region: COG0393
1048245005650	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
1048245005651	putative transposase OrfB; Reviewed; Region: PHA02517
1048245005652	HTH-like domain; Region: HTH_21; pfam13276
1048245005653	Integrase core domain; Region: rve; pfam00665
1048245005654	Integrase core domain; Region: rve_3; pfam13683
1048245005655	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245005656	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245005657	active site
1048245005658	Integrase core domain; Region: rve; pfam00665
1048245005659	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1048245005660	putative homotetramer interface [polypeptide binding]; other site
1048245005661	putative homodimer interface [polypeptide binding]; other site
1048245005662	putative allosteric switch controlling residues; other site
1048245005663	putative metal binding site [ion binding]; other site
1048245005664	putative homodimer-homodimer interface [polypeptide binding]; other site
1048245005665	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1048245005666	PE family; Region: PE; pfam00934
1048245005667	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1048245005668	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
1048245005669	dimer interface [polypeptide binding]; other site
1048245005670	active site
1048245005671	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1048245005672	substrate binding site [chemical binding]; other site
1048245005673	catalytic residue [active]
1048245005674	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
1048245005675	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1048245005676	metal binding site [ion binding]; metal-binding site
1048245005677	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
1048245005678	FAD binding domain; Region: FAD_binding_4; pfam01565
1048245005679	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1048245005681	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
1048245005682	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1048245005683	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1048245005684	Bacterial transcriptional regulator; Region: IclR; pfam01614
1048245005685	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1048245005686	FAD binding domain; Region: FAD_binding_4; pfam01565
1048245005688	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245005689	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245005690	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245005691	Cytochrome P450; Region: p450; cl12078
1048245005693	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
1048245005694	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
1048245005695	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
1048245005696	Protein of unknown function (DUF690); Region: DUF690; pfam05108
1048245005697	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1048245005698	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1048245005699	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1048245005700	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1048245005703	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245005704	Cytochrome P450; Region: p450; cl12078
1048245005706	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1048245005707	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245005708	PPE family; Region: PPE; pfam00823
1048245005709	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245005710	PE family; Region: PE; pfam00934
1048245005711	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245005712	PPE family; Region: PPE; pfam00823
1048245005713	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245005714	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245005715	PPE family; Region: PPE; pfam00823
1048245005716	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245005717	PE family; Region: PE; pfam00934
1048245005718	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1048245005719	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1048245005720	EspG family; Region: ESX-1_EspG; pfam14011
1048245005722	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1048245005723	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1048245005724	catalytic residues [active]
1048245005725	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1048245005726	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
1048245005727	active site
1048245005728	catalytic residues [active]
1048245005731	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
1048245005732	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
1048245005733	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245005734	Walker A motif; other site
1048245005735	ATP binding site [chemical binding]; other site
1048245005736	Walker B motif; other site
1048245005737	arginine finger; other site
1048245005739	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245005740	PPE family; Region: PPE; pfam00823
1048245005741	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245005742	PPE family; Region: PPE; pfam00823
1048245005743	PE family; Region: PE; pfam00934
1048245005746	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1048245005748	PE family; Region: PE; pfam00934
1048245005749	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245005750	PPE family; Region: PPE; pfam00823
1048245005751	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245005752	PPE family; Region: PPE; pfam00823
1048245005753	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245005754	PPE family; Region: PPE; pfam00823
1048245005755	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245005756	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1048245005757	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1048245005758	MgtC family; Region: MgtC; pfam02308
1048245005759	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1048245005760	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1048245005761	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
1048245005762	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1048245005763	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1048245005764	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245005765	hypothetical protein; Validated; Region: PRK07121
1048245005766	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1048245005767	ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472
1048245005768	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1048245005771	hypothetical protein; Provisional; Region: PRK05858
1048245005772	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1048245005773	PYR/PP interface [polypeptide binding]; other site
1048245005774	dimer interface [polypeptide binding]; other site
1048245005775	TPP binding site [chemical binding]; other site
1048245005776	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1048245005777	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
1048245005778	TPP-binding site; other site
1048245005779	dimer interface [polypeptide binding]; other site
1048245005781	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
1048245005782	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1048245005783	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1048245005784	nucleotide binding region [chemical binding]; other site
1048245005785	ATP-binding site [chemical binding]; other site
1048245005786	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1048245005789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
1048245005790	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1048245005791	Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856
1048245005792	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
1048245005793	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1048245005794	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1048245005795	lipoyl attachment site [posttranslational modification]; other site
1048245005797	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1048245005798	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1048245005799	phosphopeptide binding site; other site
1048245005800	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1048245005801	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1048245005802	DNA binding residues [nucleotide binding]
1048245005803	Bifunctional nuclease; Region: DNase-RNase; pfam02577
1048245005804	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1048245005805	DNA binding residues [nucleotide binding]
1048245005806	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1048245005807	putative dimer interface [polypeptide binding]; other site
1048245005808	glycine dehydrogenase; Provisional; Region: PRK05367
1048245005809	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1048245005810	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245005811	tetramer interface [polypeptide binding]; other site
1048245005812	catalytic residue [active]
1048245005813	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1048245005814	tetramer interface [polypeptide binding]; other site
1048245005815	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245005816	catalytic residue [active]
1048245005817	haloalkane dehalogenase; Provisional; Region: PRK03204
1048245005818	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1048245005819	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
1048245005820	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1048245005821	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1048245005822	metal ion-dependent adhesion site (MIDAS); other site
1048245005824	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
1048245005825	active site
1048245005826	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1048245005827	putative active site [active]
1048245005828	Domain of unknown function DUF21; Region: DUF21; pfam01595
1048245005829	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1048245005830	FOG: CBS domain [General function prediction only]; Region: COG0517
1048245005831	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1048245005832	Domain of unknown function DUF21; Region: DUF21; pfam01595
1048245005833	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1048245005834	Transporter associated domain; Region: CorC_HlyC; smart01091
1048245005835	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
1048245005836	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
1048245005837	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1048245005838	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1048245005839	active site
1048245005840	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1048245005841	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1048245005842	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1048245005843	Peptidase family M48; Region: Peptidase_M48; cl12018
1048245005844	Predicted transcriptional regulator [Transcription]; Region: COG3682
1048245005845	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1048245005846	CoenzymeA binding site [chemical binding]; other site
1048245005847	subunit interaction site [polypeptide binding]; other site
1048245005848	PHB binding site; other site
1048245005849	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1048245005850	alpha-gamma subunit interface [polypeptide binding]; other site
1048245005851	beta-gamma subunit interface [polypeptide binding]; other site
1048245005852	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1048245005853	gamma-beta subunit interface [polypeptide binding]; other site
1048245005854	alpha-beta subunit interface [polypeptide binding]; other site
1048245005855	urease subunit alpha; Reviewed; Region: ureC; PRK13206
1048245005856	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1048245005857	subunit interactions [polypeptide binding]; other site
1048245005858	active site
1048245005859	flap region; other site
1048245005861	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1048245005862	UreF; Region: UreF; pfam01730
1048245005863	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1048245005865	UreD urease accessory protein; Region: UreD; cl00530
1048245005866	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1048245005867	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1048245005868	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
1048245005869	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1048245005870	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1048245005872	classical (c) SDRs; Region: SDR_c; cd05233
1048245005873	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
1048245005874	NAD(P) binding site [chemical binding]; other site
1048245005875	active site
1048245005876	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1048245005877	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1048245005879	sulfate transport protein; Provisional; Region: cysT; CHL00187
1048245005880	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245005881	dimer interface [polypeptide binding]; other site
1048245005882	conserved gate region; other site
1048245005883	putative PBP binding loops; other site
1048245005884	ABC-ATPase subunit interface; other site
1048245005885	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1048245005886	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1048245005887	Walker A/P-loop; other site
1048245005888	ATP binding site [chemical binding]; other site
1048245005889	Q-loop/lid; other site
1048245005890	ABC transporter signature motif; other site
1048245005891	Walker B; other site
1048245005892	D-loop; other site
1048245005893	H-loop/switch region; other site
1048245005894	TOBE domain; Region: TOBE; pfam03459
1048245005897	Fibronectin-attachment protein (FAP); Region: FAP; pfam07174
1048245005898	Predicted membrane protein [Function unknown]; Region: COG2261
1048245005900	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
1048245005901	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
1048245005902	putative NAD(P) binding site [chemical binding]; other site
1048245005903	putative substrate binding site [chemical binding]; other site
1048245005904	catalytic Zn binding site [ion binding]; other site
1048245005905	structural Zn binding site [ion binding]; other site
1048245005907	CAAX protease self-immunity; Region: Abi; pfam02517
1048245005908	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1048245005909	MOSC domain; Region: MOSC; pfam03473
1048245005910	short chain dehydrogenase; Provisional; Region: PRK07825
1048245005911	classical (c) SDRs; Region: SDR_c; cd05233
1048245005912	NAD(P) binding site [chemical binding]; other site
1048245005913	active site
1048245005915	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1048245005916	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1048245005917	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1048245005918	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1048245005919	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
1048245005920	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1048245005921	active site
1048245005922	hypothetical protein; Provisional; Region: PRK12320
1048245005923	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245005924	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1048245005925	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1048245005926	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1048245005927	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1048245005928	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
1048245005929	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1048245005930	active site
1048245005931	substrate binding site [chemical binding]; other site
1048245005932	FMN binding site [chemical binding]; other site
1048245005933	putative catalytic residues [active]
1048245005935	Uncharacterized conserved protein [Function unknown]; Region: COG5579
1048245005936	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1048245005937	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1048245005938	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1048245005939	heme binding site [chemical binding]; other site
1048245005940	ferroxidase pore; other site
1048245005941	ferroxidase diiron center [ion binding]; other site
1048245005942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245005943	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1048245005944	putative substrate translocation pore; other site
1048245005945	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245005946	putative substrate translocation pore; other site
1048245005947	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333
1048245005948	23S rRNA interface [nucleotide binding]; other site
1048245005949	L3 interface [polypeptide binding]; other site
1048245005950	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1048245005952	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1048245005953	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1048245005954	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1048245005955	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245005956	Cytochrome P450; Region: p450; cl12078
1048245005958	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
1048245005959	short chain dehydrogenase; Provisional; Region: PRK08267
1048245005960	classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931
1048245005961	putative NAD(P) binding site [chemical binding]; other site
1048245005962	active site
1048245005964	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1048245005965	hydrophobic ligand binding site; other site
1048245005966	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1048245005967	chorismate mutase; Provisional; Region: PRK09269
1048245005968	chorismate mutase, putative; Region: CM_mono2; TIGR01806
1048245005969	Putative esterase; Region: Esterase; pfam00756
1048245005971	Leucine carboxyl methyltransferase; Region: LCM; cl01306
1048245005972	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1048245005973	Leucine carboxyl methyltransferase; Region: LCM; cl01306
1048245005974	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1048245005975	Nitronate monooxygenase; Region: NMO; pfam03060
1048245005976	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1048245005977	FMN binding site [chemical binding]; other site
1048245005978	substrate binding site [chemical binding]; other site
1048245005979	putative catalytic residue [active]
1048245005980	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284
1048245005981	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1048245005982	catalytic Zn binding site [ion binding]; other site
1048245005983	NAD(P) binding site [chemical binding]; other site
1048245005984	structural Zn binding site [ion binding]; other site
1048245005985	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1048245005986	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1048245005987	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1048245005988	putative active site [active]
1048245005989	dimerization interface [polypeptide binding]; other site
1048245005990	putative tRNAtyr binding site [nucleotide binding]; other site
1048245005991	Domain of unknown function DUF77; Region: DUF77; pfam01910
1048245005992	Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330
1048245005993	putative ADP-ribose binding site [chemical binding]; other site
1048245005995	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245005996	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1048245005997	cyclase homology domain; Region: CHD; cd07302
1048245005998	nucleotidyl binding site; other site
1048245005999	metal binding site [ion binding]; metal-binding site
1048245006000	dimer interface [polypeptide binding]; other site
1048245006001	competence damage-inducible protein A; Provisional; Region: PRK00549
1048245006002	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1048245006003	putative MPT binding site; other site
1048245006004	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
1048245006005	putative sialic acid transporter; Region: 2A0112; TIGR00891
1048245006006	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245006007	putative substrate translocation pore; other site
1048245006009	Predicted membrane protein [Function unknown]; Region: COG1950
1048245006010	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1048245006011	anti sigma factor interaction site; other site
1048245006012	regulatory phosphorylation site [posttranslational modification]; other site
1048245006013	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1048245006014	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
1048245006015	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1048245006016	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
1048245006017	dimer interface [polypeptide binding]; other site
1048245006018	active site
1048245006019	heme binding site [chemical binding]; other site
1048245006020	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1048245006023	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1048245006024	metal binding site 2 [ion binding]; metal-binding site
1048245006025	putative DNA binding helix; other site
1048245006026	metal binding site 1 [ion binding]; metal-binding site
1048245006027	dimer interface [polypeptide binding]; other site
1048245006028	structural Zn2+ binding site [ion binding]; other site
1048245006029	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1048245006030	substrate binding site [chemical binding]; other site
1048245006031	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1048245006032	substrate binding site [chemical binding]; other site
1048245006034	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1048245006035	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275
1048245006036	putative NAD(P) binding site [chemical binding]; other site
1048245006038	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1048245006039	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1048245006040	tetramer interface [polypeptide binding]; other site
1048245006041	active site
1048245006042	Mg2+/Mn2+ binding site [ion binding]; other site
1048245006043	Isocitrate lyase [Energy production and conversion]; Region: AceA; COG2224
1048245006044	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245006045	PPE family; Region: PPE; pfam00823
1048245006046	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245006047	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245006048	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245006049	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245006050	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245006051	PPE family; Region: PPE; pfam00823
1048245006052	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245006053	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245006054	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1048245006055	putative hydrophobic ligand binding site [chemical binding]; other site
1048245006056	protein interface [polypeptide binding]; other site
1048245006057	gate; other site
1048245006058	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1048245006059	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
1048245006060	putative acyl-acceptor binding pocket; other site
1048245006061	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1048245006063	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1048245006064	Beta-lactamase; Region: Beta-lactamase; pfam00144
1048245006066	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1048245006067	Beta-lactamase; Region: Beta-lactamase; pfam00144
1048245006068	putative fatty-acid--CoA ligase; Provisional; Region: PRK12476
1048245006069	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1048245006070	acyl-activating enzyme (AAE) consensus motif; other site
1048245006071	active site
1048245006072	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
1048245006073	Uncharacterized conserved protein [Function unknown]; Region: COG3361
1048245006074	short chain dehydrogenase; Provisional; Region: PRK05867
1048245006075	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245006076	NAD(P) binding site [chemical binding]; other site
1048245006077	active site
1048245006079	TIGR03085 family protein; Region: TIGR03085
1048245006080	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1048245006081	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1048245006082	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
1048245006083	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1048245006084	conserved cys residue [active]
1048245006085	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1048245006086	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1048245006087	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1048245006088	dimer interface [polypeptide binding]; other site
1048245006089	catalytic triad [active]
1048245006090	peroxidatic and resolving cysteines [active]
1048245006091	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245006092	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1048245006093	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1048245006094	active site
1048245006095	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245006096	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
1048245006097	FAD binding site [chemical binding]; other site
1048245006098	substrate binding site [chemical binding]; other site
1048245006099	catalytic base [active]
1048245006100	enoyl-CoA hydratase; Provisional; Region: PRK08290
1048245006101	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245006102	substrate binding site [chemical binding]; other site
1048245006103	oxyanion hole (OAH) forming residues; other site
1048245006104	trimer interface [polypeptide binding]; other site
1048245006105	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1048245006106	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1048245006107	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
1048245006108	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1048245006109	catalytic loop [active]
1048245006110	iron binding site [ion binding]; other site
1048245006111	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
1048245006112	FAD binding pocket [chemical binding]; other site
1048245006113	FAD binding motif [chemical binding]; other site
1048245006114	phosphate binding motif [ion binding]; other site
1048245006115	beta-alpha-beta structure motif; other site
1048245006116	NAD binding pocket [chemical binding]; other site
1048245006118	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245006119	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1048245006120	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1048245006121	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
1048245006122	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1048245006123	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
1048245006124	dimerization interface [polypeptide binding]; other site
1048245006125	active site
1048245006126	classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944
1048245006127	putative NAD(P) binding site [chemical binding]; other site
1048245006128	active site
1048245006129	homodimer interface [polypeptide binding]; other site
1048245006131	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1048245006132	SEC-C motif; Region: SEC-C; pfam02810
1048245006133	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245006134	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245006135	active site
1048245006137	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
1048245006138	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487
1048245006139	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
1048245006140	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1048245006141	non-specific DNA binding site [nucleotide binding]; other site
1048245006142	salt bridge; other site
1048245006143	sequence-specific DNA binding site [nucleotide binding]; other site
1048245006144	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
1048245006145	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
1048245006146	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
1048245006147	putative active site [active]
1048245006148	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245006149	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245006150	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245006151	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245006152	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1048245006153	Permease; Region: Permease; pfam02405
1048245006154	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1048245006155	Permease; Region: Permease; pfam02405
1048245006156	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245006157	mce related protein; Region: MCE; pfam02470
1048245006158	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1048245006159	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245006160	mce related protein; Region: MCE; pfam02470
1048245006161	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245006162	mce related protein; Region: MCE; pfam02470
1048245006163	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245006164	mce related protein; Region: MCE; pfam02470
1048245006165	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245006166	mce related protein; Region: MCE; pfam02470
1048245006168	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245006169	mce related protein; Region: MCE; pfam02470
1048245006170	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1048245006171	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1048245006172	YacP-like NYN domain; Region: NYN_YacP; cl01491
1048245006173	PE family; Region: PE; pfam00934
1048245006174	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
1048245006175	Peptidase family M48; Region: Peptidase_M48; pfam01435
1048245006177	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245006178	S-adenosylmethionine binding site [chemical binding]; other site
1048245006179	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1048245006181	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1048245006182	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1048245006183	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1048245006184	dimer interface [polypeptide binding]; other site
1048245006185	putative radical transfer pathway; other site
1048245006186	diiron center [ion binding]; other site
1048245006187	tyrosyl radical; other site
1048245006189	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
1048245006190	putative active site [active]
1048245006191	PE family; Region: PE; pfam00934
1048245006193	Cutinase; Region: Cutinase; pfam01083
1048245006194	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1048245006195	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1048245006196	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1048245006197	dimerization interface [polypeptide binding]; other site
1048245006199	Lysine efflux permease [General function prediction only]; Region: COG1279
1048245006200	Cellulose binding domain; Region: CBM_2; pfam00553
1048245006201	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245006202	S-adenosylmethionine binding site [chemical binding]; other site
1048245006206	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1048245006207	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1048245006208	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1048245006211	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
1048245006212	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1048245006213	dimerization interface [polypeptide binding]; other site
1048245006214	putative DNA binding site [nucleotide binding]; other site
1048245006215	putative Zn2+ binding site [ion binding]; other site
1048245006216	Hemerythrin-like domain; Region: Hr-like; cd12108
1048245006217	Fe binding site [ion binding]; other site
1048245006218	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1048245006219	Ligand Binding Site [chemical binding]; other site
1048245006220	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1048245006221	Ligand Binding Site [chemical binding]; other site
1048245006222	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1048245006223	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1048245006224	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1048245006225	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1048245006226	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1048245006227	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1048245006229	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1048245006230	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1048245006231	tetramer interface [polypeptide binding]; other site
1048245006232	active site
1048245006233	Mg2+/Mn2+ binding site [ion binding]; other site
1048245006234	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1048245006235	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1048245006236	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
1048245006237	3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341
1048245006238	homotetramer interface [polypeptide binding]; other site
1048245006239	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1048245006240	NAD binding site [chemical binding]; other site
1048245006241	homodimer interface [polypeptide binding]; other site
1048245006242	active site
1048245006245	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
1048245006246	Predicted kinase [General function prediction only]; Region: COG0645
1048245006247	AAA domain; Region: AAA_17; pfam13207
1048245006249	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1048245006250	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1048245006251	Ligand Binding Site [chemical binding]; other site
1048245006252	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1048245006253	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
1048245006254	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
1048245006255	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
1048245006256	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1048245006257	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1048245006258	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1048245006260	Ferredoxin [Energy production and conversion]; Region: COG1146
1048245006264	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1048245006265	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1048245006266	putative active site [active]
1048245006267	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1048245006268	MarR family; Region: MarR_2; pfam12802
1048245006269	Phage envelope protein [General function prediction only]; Region: COG5562
1048245006270	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1048245006271	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1048245006272	Integrase core domain; Region: rve; pfam00665
1048245006273	Integrase core domain; Region: rve_3; cl15866
1048245006274	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1048245006275	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245006276	Walker A motif; other site
1048245006277	ATP binding site [chemical binding]; other site
1048245006278	Walker B motif; other site
1048245006279	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1048245006280	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1048245006281	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1048245006282	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245006283	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245006284	active site
1048245006285	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1048245006286	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1048245006287	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1048245006288	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1048245006289	non-specific DNA binding site [nucleotide binding]; other site
1048245006290	salt bridge; other site
1048245006291	sequence-specific DNA binding site [nucleotide binding]; other site
1048245006292	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
1048245006294	Uncharacterized conserved protein [Function unknown]; Region: COG2442
1048245006296	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1048245006297	non-specific DNA binding site [nucleotide binding]; other site
1048245006298	salt bridge; other site
1048245006299	sequence-specific DNA binding site [nucleotide binding]; other site
1048245006300	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683
1048245006301	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
1048245006302	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
1048245006303	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1048245006304	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1048245006305	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1048245006306	Ligand Binding Site [chemical binding]; other site
1048245006307	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1048245006308	Ligand Binding Site [chemical binding]; other site
1048245006309	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1048245006310	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1048245006311	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1048245006312	Histidine kinase; Region: HisKA_3; pfam07730
1048245006313	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1048245006314	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1048245006315	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1048245006316	putative substrate binding site [chemical binding]; other site
1048245006317	putative ATP binding site [chemical binding]; other site
1048245006319	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1048245006320	active site
1048245006321	Erythromycin esterase homolog [General function prediction only]; Region: COG2312
1048245006322	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1048245006323	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1048245006324	putative dimer interface [polypeptide binding]; other site
1048245006325	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1048245006326	dimer interface [polypeptide binding]; other site
1048245006327	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
1048245006328	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1048245006329	putative DNA binding site [nucleotide binding]; other site
1048245006330	dimerization interface [polypeptide binding]; other site
1048245006331	putative Zn2+ binding site [ion binding]; other site
1048245006332	Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891
1048245006333	putative hydrophobic ligand binding site [chemical binding]; other site
1048245006334	CLM binding site; other site
1048245006335	L1 loop; other site
1048245006336	DNA binding site [nucleotide binding]
1048245006337	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1048245006338	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1048245006339	MDMPI C-terminal domain; Region: MDMPI_C; pfam07398
1048245006340	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1048245006341	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
1048245006342	nucleophile elbow; other site
1048245006343	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1048245006344	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1048245006345	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1048245006346	Walker A/P-loop; other site
1048245006347	ATP binding site [chemical binding]; other site
1048245006348	Q-loop/lid; other site
1048245006349	ABC transporter signature motif; other site
1048245006350	Walker B; other site
1048245006351	D-loop; other site
1048245006352	H-loop/switch region; other site
1048245006353	TOBE domain; Region: TOBE_2; pfam08402
1048245006356	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1048245006357	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245006358	dimer interface [polypeptide binding]; other site
1048245006359	conserved gate region; other site
1048245006360	putative PBP binding loops; other site
1048245006361	ABC-ATPase subunit interface; other site
1048245006363	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1048245006364	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245006365	dimer interface [polypeptide binding]; other site
1048245006366	conserved gate region; other site
1048245006367	putative PBP binding loops; other site
1048245006368	ABC-ATPase subunit interface; other site
1048245006370	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1048245006371	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1048245006373	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
1048245006374	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1048245006375	Isochorismatase family; Region: Isochorismatase; pfam00857
1048245006376	catalytic triad [active]
1048245006377	metal binding site [ion binding]; metal-binding site
1048245006378	conserved cis-peptide bond; other site
1048245006379	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
1048245006380	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1048245006381	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1048245006382	substrate binding pocket [chemical binding]; other site
1048245006383	catalytic triad [active]
1048245006387	hypothetical protein; Provisional; Region: PRK05865
1048245006388	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245006389	NAD(P) binding site [chemical binding]; other site
1048245006390	active site
1048245006391	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1048245006392	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1048245006393	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245006394	active site
1048245006395	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1048245006396	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1048245006397	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245006398	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1048245006399	Enoylreductase; Region: PKS_ER; smart00829
1048245006400	NAD(P) binding site [chemical binding]; other site
1048245006401	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
1048245006402	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1048245006403	putative NADP binding site [chemical binding]; other site
1048245006404	active site
1048245006405	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245006406	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1048245006407	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245006408	active site
1048245006409	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1048245006410	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1048245006411	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245006412	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1048245006413	Enoylreductase; Region: PKS_ER; smart00829
1048245006414	NAD(P) binding site [chemical binding]; other site
1048245006415	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
1048245006416	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1048245006417	putative NADP binding site [chemical binding]; other site
1048245006418	active site
1048245006419	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245006424	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
1048245006425	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
1048245006426	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1048245006427	putative active site [active]
1048245006428	catalytic triad [active]
1048245006429	putative dimer interface [polypeptide binding]; other site
1048245006430	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
1048245006431	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
1048245006432	Ligand binding site; other site
1048245006433	Putative Catalytic site; other site
1048245006434	DXD motif; other site
1048245006435	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1048245006436	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1048245006437	active site
1048245006438	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
1048245006439	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1048245006440	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
1048245006441	30S ribosomal protein S18; Provisional; Region: PRK13401
1048245006442	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1048245006443	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1048245006444	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1048245006445	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1048245006446	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1048245006447	intersubunit interface [polypeptide binding]; other site
1048245006448	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1048245006449	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1048245006450	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
1048245006451	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
1048245006452	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1048245006453	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1048245006454	precorrin-3B synthase; Region: CobG; TIGR02435
1048245006455	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1048245006456	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1048245006458	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
1048245006459	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1048245006460	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1048245006461	active site
1048245006462	SAM binding site [chemical binding]; other site
1048245006463	homodimer interface [polypeptide binding]; other site
1048245006464	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1048245006465	active site
1048245006466	SAM binding site [chemical binding]; other site
1048245006467	homodimer interface [polypeptide binding]; other site
1048245006468	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1048245006469	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245006470	S-adenosylmethionine binding site [chemical binding]; other site
1048245006471	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1048245006472	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1048245006474	RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649
1048245006475	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1048245006476	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1048245006477	DNA binding residues [nucleotide binding]
1048245006478	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
1048245006479	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
1048245006480	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1048245006481	active site
1048245006482	SAM binding site [chemical binding]; other site
1048245006483	homodimer interface [polypeptide binding]; other site
1048245006486	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1048245006487	active site
1048245006488	putative homodimer interface [polypeptide binding]; other site
1048245006489	SAM binding site [chemical binding]; other site
1048245006490	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1048245006491	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1048245006492	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245006493	NAD(P) binding site [chemical binding]; other site
1048245006494	active site
1048245006495	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1048245006496	Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590
1048245006497	putative active site [active]
1048245006498	catalytic site [active]
1048245006499	putative metal binding site [ion binding]; other site
1048245006500	C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432
1048245006501	Protein of unknown function (DUF2563); Region: DUF2563; pfam10817
1048245006502	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
1048245006505	hypothetical protein; Provisional; Region: PRK12705
1048245006506	putative transposase OrfB; Reviewed; Region: PHA02517
1048245006507	HTH-like domain; Region: HTH_21; pfam13276
1048245006508	Integrase core domain; Region: rve; pfam00665
1048245006509	Integrase core domain; Region: rve_3; pfam13683
1048245006510	hypothetical protein; Provisional; Region: PRK12705
1048245006511	putative transposase OrfB; Reviewed; Region: PHA02517
1048245006512	HTH-like domain; Region: HTH_21; pfam13276
1048245006513	Integrase core domain; Region: rve; pfam00665
1048245006514	Integrase core domain; Region: rve_3; pfam13683
1048245006515	Transposase; Region: HTH_Tnp_1; cl17663
1048245006516	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1048245006517	putative transposase OrfB; Reviewed; Region: PHA02517
1048245006518	HTH-like domain; Region: HTH_21; pfam13276
1048245006519	Integrase core domain; Region: rve; pfam00665
1048245006520	Integrase core domain; Region: rve_3; pfam13683
1048245006522	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1048245006523	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1048245006524	active site
1048245006526	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
1048245006527	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1048245006528	active site
1048245006529	metal binding site 1 [ion binding]; metal-binding site
1048245006530	putative 5' ssDNA interaction site; other site
1048245006531	metal binding site 3; metal-binding site
1048245006532	metal binding site 2 [ion binding]; metal-binding site
1048245006533	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1048245006534	putative DNA binding site [nucleotide binding]; other site
1048245006535	putative metal binding site [ion binding]; other site
1048245006536	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
1048245006537	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
1048245006538	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1048245006539	ATP binding site [chemical binding]; other site
1048245006540	putative Mg++ binding site [ion binding]; other site
1048245006541	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1048245006542	nucleotide binding region [chemical binding]; other site
1048245006543	ATP-binding site [chemical binding]; other site
1048245006544	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
1048245006547	Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945
1048245006548	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
1048245006549	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
1048245006551	Predicted transcriptional regulator [Transcription]; Region: COG2378
1048245006552	WYL domain; Region: WYL; pfam13280
1048245006553	Predicted transcriptional regulator [Transcription]; Region: COG2378
1048245006554	WYL domain; Region: WYL; pfam13280
1048245006555	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
1048245006556	PE family; Region: PE; pfam00934
1048245006557	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245006558	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245006559	active site
1048245006560	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
1048245006561	SNF2 Helicase protein; Region: DUF3670; pfam12419
1048245006562	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1048245006563	ATP binding site [chemical binding]; other site
1048245006564	putative Mg++ binding site [ion binding]; other site
1048245006565	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1048245006566	nucleotide binding region [chemical binding]; other site
1048245006567	ATP-binding site [chemical binding]; other site
1048245006568	Uncharacterized conserved protein [Function unknown]; Region: COG4279
1048245006570	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1048245006571	putative active site [active]
1048245006572	PE family; Region: PE; pfam00934
1048245006573	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245006574	PPE family; Region: PPE; pfam00823
1048245006575	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
1048245006576	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
1048245006577	active site
1048245006578	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
1048245006579	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
1048245006580	active site
1048245006581	Pup-like protein; Region: Pup; pfam05639
1048245006583	proteasome ATPase; Region: pup_AAA; TIGR03689
1048245006584	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245006585	Walker A motif; other site
1048245006586	ATP binding site [chemical binding]; other site
1048245006587	Walker B motif; other site
1048245006588	arginine finger; other site
1048245006592	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550
1048245006593	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
1048245006594	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245006595	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
1048245006596	Predicted membrane protein [Function unknown]; Region: COG3918
1048245006597	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1048245006598	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
1048245006599	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
1048245006600	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
1048245006601	homodimer interface [polypeptide binding]; other site
1048245006602	putative metal binding site [ion binding]; other site
1048245006603	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245006604	PPE family; Region: PPE; pfam00823
1048245006605	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1048245006606	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1048245006607	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1048245006608	substrate binding pocket [chemical binding]; other site
1048245006609	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1048245006610	B12 binding site [chemical binding]; other site
1048245006611	cobalt ligand [ion binding]; other site
1048245006612	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1048245006614	PAC2 family; Region: PAC2; pfam09754
1048245006615	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1048245006617	short chain dehydrogenase; Provisional; Region: PRK05872
1048245006618	classical (c) SDRs; Region: SDR_c; cd05233
1048245006619	NAD(P) binding site [chemical binding]; other site
1048245006620	active site
1048245006621	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1048245006622	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
1048245006623	active site
1048245006624	HIGH motif; other site
1048245006625	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1048245006626	active site
1048245006627	KMSKS motif; other site
1048245006628	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
1048245006629	putative tRNA binding surface [nucleotide binding]; other site
1048245006630	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1048245006631	active site
1048245006633	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1048245006634	conserved hypothetical protein; Region: TIGR03843
1048245006635	conserved hypothetical protein; Region: TIGR03847
1048245006636	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1048245006637	catalytic core [active]
1048245006638	undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753
1048245006641	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1048245006642	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1048245006643	quinone interaction residues [chemical binding]; other site
1048245006644	active site
1048245006645	catalytic residues [active]
1048245006646	FMN binding site [chemical binding]; other site
1048245006647	substrate binding site [chemical binding]; other site
1048245006650	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1048245006651	substrate binding site [chemical binding]; other site
1048245006652	hypothetical protein; Provisional; Region: PRK07906
1048245006653	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
1048245006654	putative metal binding site [ion binding]; other site
1048245006656	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
1048245006657	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1048245006658	active site
1048245006659	DivIVA domain; Region: DivI1A_domain; TIGR03544
1048245006660	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1048245006661	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1048245006662	Predicted integral membrane protein [Function unknown]; Region: COG0762
1048245006663	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1048245006664	Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325
1048245006665	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1048245006666	catalytic residue [active]
1048245006667	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1048245006668	uncharacterized protein, YfiH family; Region: TIGR00726
1048245006669	cell division protein FtsZ; Validated; Region: PRK09330
1048245006670	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1048245006671	nucleotide binding site [chemical binding]; other site
1048245006672	SulA interaction site; other site
1048245006674	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1048245006675	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1048245006676	Cell division protein FtsQ; Region: FtsQ; pfam03799
1048245006677	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1048245006678	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1048245006679	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1048245006680	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1048245006681	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1048245006682	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
1048245006683	active site
1048245006684	homodimer interface [polypeptide binding]; other site
1048245006685	cell division protein FtsW; Region: ftsW; TIGR02614
1048245006686	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369
1048245006687	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1048245006688	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1048245006690	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1048245006691	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1048245006692	Mg++ binding site [ion binding]; other site
1048245006693	putative catalytic motif [active]
1048245006694	putative substrate binding site [chemical binding]; other site
1048245006695	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1048245006696	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1048245006697	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1048245006698	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1048245006699	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1048245006700	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1048245006701	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245006702	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245006703	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1048245006704	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1048245006705	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1048245006706	PE family; Region: PE; pfam00934
1048245006707	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1048245006708	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1048245006709	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1048245006711	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1048245006712	MraW methylase family; Region: Methyltransf_5; pfam01795
1048245006713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
1048245006714	MraZ protein; Region: MraZ; pfam02381
1048245006715	MraZ protein; Region: MraZ; pfam02381
1048245006716	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
1048245006717	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
1048245006720	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1048245006721	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1048245006722	substrate binding pocket [chemical binding]; other site
1048245006723	chain length determination region; other site
1048245006724	substrate-Mg2+ binding site; other site
1048245006725	catalytic residues [active]
1048245006726	aspartate-rich region 1; other site
1048245006727	active site lid residues [active]
1048245006728	aspartate-rich region 2; other site
1048245006731	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1048245006732	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1048245006733	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1048245006734	active site
1048245006735	ATP binding site [chemical binding]; other site
1048245006736	substrate binding site [chemical binding]; other site
1048245006737	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1048245006738	substrate binding site [chemical binding]; other site
1048245006739	activation loop (A-loop); other site
1048245006740	activation loop (A-loop); other site
1048245006743	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200
1048245006744	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
1048245006745	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1048245006746	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1048245006747	putative acyl-acceptor binding pocket; other site
1048245006749	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1048245006750	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1048245006751	DTAP/Switch II; other site
1048245006752	Switch I; other site
1048245006753	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1048245006754	putative hydrophobic ligand binding site [chemical binding]; other site
1048245006755	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1048245006756	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1048245006757	acyl-activating enzyme (AAE) consensus motif; other site
1048245006758	putative AMP binding site [chemical binding]; other site
1048245006759	putative active site [active]
1048245006760	putative CoA binding site [chemical binding]; other site
1048245006762	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1048245006763	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1048245006764	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
1048245006765	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1048245006766	NlpC/P60 family; Region: NLPC_P60; pfam00877
1048245006767	hypothetical protein; Validated; Region: PRK07883
1048245006768	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1048245006769	active site
1048245006770	catalytic site [active]
1048245006771	substrate binding site [chemical binding]; other site
1048245006772	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1048245006773	GIY-YIG motif/motif A; other site
1048245006774	active site
1048245006775	catalytic site [active]
1048245006776	putative DNA binding site [nucleotide binding]; other site
1048245006777	metal binding site [ion binding]; metal-binding site
1048245006778	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1048245006779	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1048245006780	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1048245006781	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
1048245006782	Subunit I/III interface [polypeptide binding]; other site
1048245006783	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1048245006784	Cytochrome c; Region: Cytochrom_C; pfam00034
1048245006785	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1048245006786	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1048245006787	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1048245006788	iron-sulfur cluster [ion binding]; other site
1048245006789	[2Fe-2S] cluster binding site [ion binding]; other site
1048245006790	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1048245006791	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1048245006792	heme bH binding site [chemical binding]; other site
1048245006793	intrachain domain interface; other site
1048245006794	heme bL binding site [chemical binding]; other site
1048245006795	interchain domain interface [polypeptide binding]; other site
1048245006796	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
1048245006797	Qo binding site; other site
1048245006798	Protein of unknown function (DUF2561); Region: DUF2561; pfam10812
1048245006799	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1048245006800	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
1048245006801	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1048245006802	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1048245006803	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1048245006804	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1048245006805	dimer interface [polypeptide binding]; other site
1048245006806	active site
1048245006807	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1048245006808	Ligand Binding Site [chemical binding]; other site
1048245006809	Molecular Tunnel; other site
1048245006810	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
1048245006811	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1048245006812	substrate binding site [chemical binding]; other site
1048245006813	ATP binding site [chemical binding]; other site
1048245006814	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1048245006815	Glycerate kinase family; Region: Gly_kinase; pfam02595
1048245006816	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
1048245006817	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1048245006818	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1048245006819	putative dimer interface [polypeptide binding]; other site
1048245006820	active site pocket [active]
1048245006821	putative cataytic base [active]
1048245006822	Cobalamin-5-phosphate synthase; Region: CobS; pfam02654
1048245006823	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1048245006824	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1048245006825	homodimer interface [polypeptide binding]; other site
1048245006826	substrate-cofactor binding pocket; other site
1048245006827	catalytic residue [active]
1048245006828	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1048245006829	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1048245006830	cyclase homology domain; Region: CHD; cd07302
1048245006831	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1048245006832	nucleotidyl binding site; other site
1048245006833	metal binding site [ion binding]; metal-binding site
1048245006834	dimer interface [polypeptide binding]; other site
1048245006835	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1048245006836	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1048245006837	interface (dimer of trimers) [polypeptide binding]; other site
1048245006838	Substrate-binding/catalytic site; other site
1048245006839	Zn-binding sites [ion binding]; other site
1048245006840	short chain dehydrogenase; Validated; Region: PRK05855
1048245006841	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1048245006842	classical (c) SDRs; Region: SDR_c; cd05233
1048245006843	NAD(P) binding site [chemical binding]; other site
1048245006844	active site
1048245006845	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
1048245006846	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1048245006847	E3 interaction surface; other site
1048245006848	lipoyl attachment site [posttranslational modification]; other site
1048245006849	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1048245006850	E3 interaction surface; other site
1048245006851	lipoyl attachment site [posttranslational modification]; other site
1048245006852	e3 binding domain; Region: E3_binding; pfam02817
1048245006853	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1048245006854	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1048245006855	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1048245006856	putative NAD(P) binding site [chemical binding]; other site
1048245006857	putative active site [active]
1048245006858	lipoate-protein ligase B; Provisional; Region: PRK14345
1048245006859	lipoyl synthase; Provisional; Region: PRK05481
1048245006860	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1048245006861	FeS/SAM binding site; other site
1048245006862	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
1048245006863	RDD family; Region: RDD; pfam06271
1048245006864	glutamine synthetase, type I; Region: GlnA; TIGR00653
1048245006865	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1048245006866	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1048245006869	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
1048245006870	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1048245006871	metal binding triad; other site
1048245006872	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1048245006873	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1048245006874	metal binding triad; other site
1048245006875	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1048245006876	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1048245006877	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1048245006878	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1048245006881	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1048245006882	TAP-like protein; Region: Abhydrolase_4; pfam08386
1048245006884	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1048245006885	oligomerization interface [polypeptide binding]; other site
1048245006886	active site
1048245006887	metal binding site [ion binding]; metal-binding site
1048245006888	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
1048245006889	putative active site; other site
1048245006890	putative metal binding residues [ion binding]; other site
1048245006891	signature motif; other site
1048245006892	putative triphosphate binding site [ion binding]; other site
1048245006893	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
1048245006894	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826
1048245006895	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
1048245006896	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1048245006897	RNA/DNA hybrid binding site [nucleotide binding]; other site
1048245006898	active site
1048245006899	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1048245006900	catalytic core [active]
1048245006901	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
1048245006902	Putative zinc ribbon domain; Region: DUF164; pfam02591
1048245006903	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
1048245006904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1048245006905	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1048245006906	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1048245006907	hypothetical protein; Provisional; Region: PRK07908
1048245006908	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1048245006909	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245006910	homodimer interface [polypeptide binding]; other site
1048245006911	catalytic residue [active]
1048245006913	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1048245006914	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1048245006915	active site
1048245006916	motif I; other site
1048245006917	motif II; other site
1048245006918	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1048245006919	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1048245006920	active site
1048245006921	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1048245006922	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
1048245006923	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
1048245006924	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1048245006925	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
1048245006926	dimer interface [polypeptide binding]; other site
1048245006927	catalytic triad [active]
1048245006928	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
1048245006929	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1048245006930	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1048245006931	dimer interface [polypeptide binding]; other site
1048245006932	TPP-binding site [chemical binding]; other site
1048245006933	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1048245006934	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1048245006935	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1048245006936	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1048245006937	acyl carrier protein; Provisional; Region: acpP; PRK00982
1048245006938	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
1048245006939	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1048245006940	dimer interface [polypeptide binding]; other site
1048245006941	active site
1048245006942	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
1048245006943	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1048245006944	dimer interface [polypeptide binding]; other site
1048245006945	active site
1048245006946	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1048245006947	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1048245006948	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1048245006949	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1048245006950	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1048245006951	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245006952	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245006953	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1048245006954	FAD binding domain; Region: FAD_binding_4; pfam01565
1048245006955	diacylglycerol kinase; Reviewed; Region: PRK11914
1048245006956	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1048245006957	Integrase core domain; Region: rve; pfam00665
1048245006958	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1048245006959	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1048245006960	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245006961	Walker A motif; other site
1048245006962	ATP binding site [chemical binding]; other site
1048245006963	Walker B motif; other site
1048245006964	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
1048245006965	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1048245006966	Beta-lactamase; Region: Beta-lactamase; pfam00144
1048245006967	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1048245006968	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245006969	S-adenosylmethionine binding site [chemical binding]; other site
1048245006970	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
1048245006971	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1048245006972	NAD binding site [chemical binding]; other site
1048245006973	catalytic Zn binding site [ion binding]; other site
1048245006974	substrate binding site [chemical binding]; other site
1048245006975	structural Zn binding site [ion binding]; other site
1048245006977	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1048245006978	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
1048245006979	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1048245006980	putative active site [active]
1048245006981	catalytic triad [active]
1048245006982	putative dimer interface [polypeptide binding]; other site
1048245006983	short chain dehydrogenase; Provisional; Region: PRK05854
1048245006984	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1048245006985	putative NAD(P) binding site [chemical binding]; other site
1048245006986	active site
1048245006987	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
1048245006988	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1048245006989	nucleotide binding site [chemical binding]; other site
1048245006990	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1048245006991	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245006992	Cytochrome P450; Region: p450; cl12078
1048245006993	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
1048245006994	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245006995	Cytochrome P450; Region: p450; cl12078
1048245006997	Septum formation; Region: Septum_form; pfam13845
1048245006998	Protein of unknown function (DUF2695); Region: DUF2695; pfam10905
1048245006999	Predicted membrane protein [Function unknown]; Region: COG2149
1048245007000	Domain of unknown function (DUF202); Region: DUF202; pfam02656
1048245007001	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245007002	Cytochrome P450; Region: p450; cl12078
1048245007004	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580
1048245007005	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1048245007006	putative active site [active]
1048245007007	catalytic site [active]
1048245007008	putative metal binding site [ion binding]; other site
1048245007009	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1048245007010	FAD binding domain; Region: FAD_binding_4; pfam01565
1048245007011	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1048245007012	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1048245007013	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1048245007014	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1048245007015	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1048245007016	dimerization interface [polypeptide binding]; other site
1048245007018	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1048245007019	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1048245007020	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1048245007021	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1048245007022	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1048245007023	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1048245007024	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1048245007025	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1048245007026	CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134
1048245007027	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1048245007028	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1048245007029	active site residue [active]
1048245007030	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1048245007031	active site residue [active]
1048245007032	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1048245007033	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
1048245007034	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1048245007035	Transposase; Region: HTH_Tnp_1; cl17663
1048245007036	Transposase; Region: HTH_Tnp_1; cl17663
1048245007037	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1048245007038	putative transposase OrfB; Reviewed; Region: PHA02517
1048245007039	HTH-like domain; Region: HTH_21; pfam13276
1048245007040	Integrase core domain; Region: rve; pfam00665
1048245007041	Integrase core domain; Region: rve_3; pfam13683
1048245007042	HTH-like domain; Region: HTH_21; pfam13276
1048245007043	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1048245007044	Integrase core domain; Region: rve; pfam00665
1048245007045	Integrase core domain; Region: rve_3; pfam13683
1048245007046	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1048245007047	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1048245007048	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245007049	homodimer interface [polypeptide binding]; other site
1048245007050	catalytic residue [active]
1048245007051	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196
1048245007052	haloalkane dehalogenase; Provisional; Region: PRK00870
1048245007053	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1048245007054	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1048245007055	active site
1048245007056	catalytic tetrad [active]
1048245007057	heat shock protein 90; Provisional; Region: PRK05218
1048245007058	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1048245007059	ATP binding site [chemical binding]; other site
1048245007060	Mg2+ binding site [ion binding]; other site
1048245007061	G-X-G motif; other site
1048245007062	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1048245007063	Cutinase; Region: Cutinase; pfam01083
1048245007065	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
1048245007066	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1048245007067	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
1048245007069	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1048245007070	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
1048245007071	Uncharacterized conserved protein [Function unknown]; Region: COG2442
1048245007072	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1048245007073	DNA binding site [nucleotide binding]
1048245007074	active site
1048245007075	Int/Topo IB signature motif; other site
1048245007076	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
1048245007077	DNA binding residues [nucleotide binding]
1048245007079	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1048245007080	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1048245007081	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1048245007082	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245007083	putative PBP binding loops; other site
1048245007084	ABC-ATPase subunit interface; other site
1048245007085	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1048245007086	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245007087	dimer interface [polypeptide binding]; other site
1048245007088	conserved gate region; other site
1048245007089	putative PBP binding loops; other site
1048245007090	ABC-ATPase subunit interface; other site
1048245007091	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1048245007092	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1048245007093	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1048245007094	Ligand Binding Site [chemical binding]; other site
1048245007095	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1048245007096	Ligand Binding Site [chemical binding]; other site
1048245007097	amino acid transporter; Region: 2A0306; TIGR00909
1048245007098	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1048245007099	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
1048245007100	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1048245007101	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1048245007102	catalytic residue [active]
1048245007104	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
1048245007105	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1048245007106	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1048245007107	Amidinotransferase; Region: Amidinotransf; pfam02274
1048245007108	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
1048245007109	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1048245007110	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1048245007111	putative DNA binding site [nucleotide binding]; other site
1048245007112	putative Zn2+ binding site [ion binding]; other site
1048245007113	AsnC family; Region: AsnC_trans_reg; pfam01037
1048245007114	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1048245007115	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1048245007116	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1048245007117	Walker A/P-loop; other site
1048245007118	ATP binding site [chemical binding]; other site
1048245007119	Q-loop/lid; other site
1048245007120	ABC transporter signature motif; other site
1048245007121	Walker B; other site
1048245007122	D-loop; other site
1048245007123	H-loop/switch region; other site
1048245007124	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1048245007125	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1048245007126	Walker A/P-loop; other site
1048245007127	ATP binding site [chemical binding]; other site
1048245007128	Q-loop/lid; other site
1048245007129	ABC transporter signature motif; other site
1048245007130	Walker B; other site
1048245007131	D-loop; other site
1048245007132	H-loop/switch region; other site
1048245007137	MarR family; Region: MarR; pfam01047
1048245007138	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1048245007139	PE family; Region: PE; pfam00934
1048245007140	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1048245007141	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245007142	putative substrate translocation pore; other site
1048245007143	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
1048245007144	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1048245007145	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1048245007146	malate dehydrogenase; Provisional; Region: PRK13529
1048245007147	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1048245007148	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1048245007149	NAD(P) binding site [chemical binding]; other site
1048245007150	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245007151	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1048245007152	putative substrate translocation pore; other site
1048245007153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245007154	putative substrate translocation pore; other site
1048245007155	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1048245007156	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1048245007157	dimer interface [polypeptide binding]; other site
1048245007158	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245007159	catalytic residue [active]
1048245007161	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1048245007162	serine O-acetyltransferase; Region: cysE; TIGR01172
1048245007163	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1048245007164	trimer interface [polypeptide binding]; other site
1048245007165	active site
1048245007166	substrate binding site [chemical binding]; other site
1048245007167	CoA binding site [chemical binding]; other site
1048245007169	hypothetical protein; Provisional; Region: PRK14851
1048245007170	hypothetical protein; Validated; Region: PRK08223
1048245007171	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
1048245007172	ATP binding site [chemical binding]; other site
1048245007173	substrate interface [chemical binding]; other site
1048245007174	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1048245007175	PE family; Region: PE; pfam00934
1048245007177	DNA primase; Validated; Region: dnaG; PRK05667
1048245007178	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1048245007179	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1048245007180	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1048245007181	active site
1048245007182	metal binding site [ion binding]; metal-binding site
1048245007183	interdomain interaction site; other site
1048245007184	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1048245007185	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
1048245007186	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
1048245007187	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1048245007188	Zn2+ binding site [ion binding]; other site
1048245007189	Mg2+ binding site [ion binding]; other site
1048245007190	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1048245007191	Repair protein; Region: Repair_PSII; pfam04536
1048245007192	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1048245007193	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1048245007194	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
1048245007195	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1048245007196	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
1048245007197	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1048245007198	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
1048245007199	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1048245007200	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245007201	PPE family; Region: PPE; pfam00823
1048245007202	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1048245007203	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245007204	PPE family; Region: PPE; pfam00823
1048245007205	PPE family; Region: PPE; pfam00823
1048245007206	PPE family; Region: PPE; pfam00823
1048245007207	PPE family; Region: PPE; pfam00823
1048245007208	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1048245007209	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1048245007210	motif 1; other site
1048245007211	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1048245007212	active site
1048245007213	motif 2; other site
1048245007214	motif 3; other site
1048245007215	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1048245007216	anticodon binding site; other site
1048245007219	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1048245007220	dimerization interface [polypeptide binding]; other site
1048245007221	putative DNA binding site [nucleotide binding]; other site
1048245007222	putative Zn2+ binding site [ion binding]; other site
1048245007223	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1048245007224	metal binding site 2 [ion binding]; metal-binding site
1048245007225	putative DNA binding helix; other site
1048245007226	metal binding site 1 [ion binding]; metal-binding site
1048245007227	dimer interface [polypeptide binding]; other site
1048245007228	structural Zn2+ binding site [ion binding]; other site
1048245007229	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1048245007230	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1048245007231	catalytic residue [active]
1048245007232	putative FPP diphosphate  binding site; other site
1048245007233	putative FPP binding hydrophobic cleft; other site
1048245007234	dimer interface [polypeptide binding]; other site
1048245007235	putative IPP diphosphate binding site; other site
1048245007237	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1048245007238	Recombination protein O N terminal; Region: RecO_N; pfam11967
1048245007239	Recombination protein O C terminal; Region: RecO_C; pfam02565
1048245007240	amidase; Provisional; Region: PRK06061
1048245007241	Amidase; Region: Amidase; pfam01425
1048245007244	GTPase Era; Reviewed; Region: era; PRK00089
1048245007245	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1048245007246	G1 box; other site
1048245007247	GTP/Mg2+ binding site [chemical binding]; other site
1048245007248	Switch I region; other site
1048245007249	G2 box; other site
1048245007250	Switch II region; other site
1048245007251	G3 box; other site
1048245007252	G4 box; other site
1048245007253	G5 box; other site
1048245007254	KH domain; Region: KH_2; pfam07650
1048245007256	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1048245007257	Domain of unknown function DUF21; Region: DUF21; pfam01595
1048245007258	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1048245007259	Transporter associated domain; Region: CorC_HlyC; smart01091
1048245007260	metal-binding heat shock protein; Provisional; Region: PRK00016
1048245007261	K homology RNA-binding domain; Region: KH; smart00322
1048245007262	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1048245007263	PhoH-like protein; Region: PhoH; pfam02562
1048245007265	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1048245007266	PE family; Region: PE; pfam00934
1048245007267	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1048245007268	RNA methyltransferase, RsmE family; Region: TIGR00046
1048245007269	chaperone protein DnaJ; Provisional; Region: PRK14278
1048245007270	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1048245007271	HSP70 interaction site [polypeptide binding]; other site
1048245007272	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1048245007273	Zn binding sites [ion binding]; other site
1048245007274	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1048245007275	dimer interface [polypeptide binding]; other site
1048245007276	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1048245007277	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1048245007278	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
1048245007279	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1048245007280	Condensation domain; Region: Condensation; pfam00668
1048245007281	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1048245007282	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1048245007283	acyl-activating enzyme (AAE) consensus motif; other site
1048245007284	AMP binding site [chemical binding]; other site
1048245007285	Condensation domain; Region: Condensation; pfam00668
1048245007286	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1048245007288	Condensation domain; Region: Condensation; pfam00668
1048245007289	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1048245007290	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1048245007291	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1048245007292	acyl-activating enzyme (AAE) consensus motif; other site
1048245007293	AMP binding site [chemical binding]; other site
1048245007294	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1048245007295	Condensation domain; Region: Condensation; pfam00668
1048245007296	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1048245007297	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1048245007298	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245007299	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1048245007302	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1048245007303	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1048245007304	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
1048245007305	NADP binding site [chemical binding]; other site
1048245007306	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1048245007307	active site
1048245007308	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245007310	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245007311	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1048245007312	active site
1048245007313	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
1048245007314	Condensation domain; Region: Condensation; pfam00668
1048245007315	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1048245007316	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1048245007317	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1048245007318	acyl-activating enzyme (AAE) consensus motif; other site
1048245007319	AMP binding site [chemical binding]; other site
1048245007320	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1048245007321	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1048245007324	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
1048245007325	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
1048245007326	acyl-activating enzyme (AAE) consensus motif; other site
1048245007327	active site
1048245007328	AMP binding site [chemical binding]; other site
1048245007329	substrate binding site [chemical binding]; other site
1048245007331	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1048245007332	salicylate synthase MbtI; Reviewed; Region: PRK07912
1048245007333	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1048245007334	Predicted permease [General function prediction only]; Region: COG3329
1048245007336	coproporphyrinogen III oxidase; Validated; Region: PRK05628
1048245007339	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1048245007340	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1048245007341	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1048245007342	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1048245007343	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1048245007344	Active Sites [active]
1048245007345	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1048245007346	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1048245007347	putative active site [active]
1048245007348	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1048245007349	putative active site [active]
1048245007350	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1048245007351	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1048245007352	Predicted membrane protein [Function unknown]; Region: COG1297
1048245007353	putative oligopeptide transporter, OPT family; Region: TIGR00733
1048245007354	PE family; Region: PE; pfam00934
1048245007355	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1048245007356	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
1048245007357	Walker A/P-loop; other site
1048245007358	ATP binding site [chemical binding]; other site
1048245007359	Q-loop/lid; other site
1048245007360	ABC transporter signature motif; other site
1048245007361	Walker B; other site
1048245007362	D-loop; other site
1048245007363	H-loop/switch region; other site
1048245007366	sulfate transport protein; Provisional; Region: cysT; CHL00187
1048245007367	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245007368	dimer interface [polypeptide binding]; other site
1048245007369	conserved gate region; other site
1048245007370	putative PBP binding loops; other site
1048245007371	ABC-ATPase subunit interface; other site
1048245007373	sulfate transport protein; Provisional; Region: cysT; CHL00187
1048245007374	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245007375	dimer interface [polypeptide binding]; other site
1048245007376	conserved gate region; other site
1048245007377	putative PBP binding loops; other site
1048245007378	ABC-ATPase subunit interface; other site
1048245007381	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
1048245007382	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1048245007383	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1048245007384	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1048245007385	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1048245007386	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1048245007387	PknH-like extracellular domain; Region: PknH_C; pfam14032
1048245007388	GTP-binding protein LepA; Provisional; Region: PRK05433
1048245007389	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1048245007390	G1 box; other site
1048245007391	putative GEF interaction site [polypeptide binding]; other site
1048245007392	GTP/Mg2+ binding site [chemical binding]; other site
1048245007393	Switch I region; other site
1048245007394	G2 box; other site
1048245007395	G3 box; other site
1048245007396	Switch II region; other site
1048245007397	G4 box; other site
1048245007398	G5 box; other site
1048245007399	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1048245007400	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1048245007401	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1048245007404	PemK-like protein; Region: PemK; pfam02452
1048245007405	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
1048245007406	FOG: CBS domain [General function prediction only]; Region: COG0517
1048245007407	ribonuclease Z; Reviewed; Region: PRK00055
1048245007408	PE family; Region: PE; pfam00934
1048245007409	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1048245007410	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1048245007411	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1048245007412	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1048245007413	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1048245007414	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1048245007415	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1048245007416	hypothetical protein; Reviewed; Region: PRK07914
1048245007417	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1048245007418	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1048245007419	Competence protein; Region: Competence; pfam03772
1048245007420	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1048245007421	Helix-hairpin-helix motif; Region: HHH; pfam00633
1048245007422	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
1048245007423	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1048245007424	Coenzyme A binding pocket [chemical binding]; other site
1048245007425	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
1048245007426	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1048245007427	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1048245007428	active site
1048245007429	catalytic triad [active]
1048245007430	oxyanion hole [active]
1048245007431	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1048245007432	catalytic core [active]
1048245007434	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1048245007435	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1048245007436	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1048245007437	active site
1048245007438	(T/H)XGH motif; other site
1048245007439	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245007440	S-adenosylmethionine binding site [chemical binding]; other site
1048245007441	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
1048245007442	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1048245007443	putative transposase OrfB; Reviewed; Region: PHA02517
1048245007444	HTH-like domain; Region: HTH_21; pfam13276
1048245007445	Integrase core domain; Region: rve; pfam00665
1048245007446	Integrase core domain; Region: rve_3; pfam13683
1048245007447	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1048245007448	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1048245007450	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
1048245007451	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1048245007452	metal ion-dependent adhesion site (MIDAS); other site
1048245007453	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1048245007454	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245007455	Walker A motif; other site
1048245007456	ATP binding site [chemical binding]; other site
1048245007457	Walker B motif; other site
1048245007458	arginine finger; other site
1048245007460	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1048245007461	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1048245007462	putative catalytic cysteine [active]
1048245007464	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1048245007465	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1048245007466	dimer interface [polypeptide binding]; other site
1048245007467	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1048245007468	catalytic triad [active]
1048245007469	peroxidatic and resolving cysteines [active]
1048245007470	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
1048245007471	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
1048245007472	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245007473	PPE family; Region: PPE; pfam00823
1048245007474	PE family; Region: PE; pfam00934
1048245007475	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1048245007476	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1048245007477	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1048245007478	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1048245007479	ligand binding site [chemical binding]; other site
1048245007480	flexible hinge region; other site
1048245007481	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1048245007482	dimerization interface [polypeptide binding]; other site
1048245007483	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
1048245007484	cyclase homology domain; Region: CHD; cd07302
1048245007485	nucleotidyl binding site; other site
1048245007486	metal binding site [ion binding]; metal-binding site
1048245007487	dimer interface [polypeptide binding]; other site
1048245007488	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1048245007489	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1048245007490	substrate binding site [chemical binding]; other site
1048245007491	dimer interface [polypeptide binding]; other site
1048245007492	ATP binding site [chemical binding]; other site
1048245007494	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1048245007495	NAD synthetase; Reviewed; Region: nadE; PRK02628
1048245007496	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
1048245007497	multimer interface [polypeptide binding]; other site
1048245007498	active site
1048245007499	catalytic triad [active]
1048245007500	protein interface 1 [polypeptide binding]; other site
1048245007501	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1048245007502	homodimer interface [polypeptide binding]; other site
1048245007503	NAD binding pocket [chemical binding]; other site
1048245007504	ATP binding pocket [chemical binding]; other site
1048245007505	Mg binding site [ion binding]; other site
1048245007506	active-site loop [active]
1048245007508	gamma-glutamyl kinase; Provisional; Region: PRK05429
1048245007509	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1048245007510	nucleotide binding site [chemical binding]; other site
1048245007511	homotetrameric interface [polypeptide binding]; other site
1048245007512	putative phosphate binding site [ion binding]; other site
1048245007513	putative allosteric binding site; other site
1048245007514	PUA domain; Region: PUA; pfam01472
1048245007516	GTPase CgtA; Reviewed; Region: obgE; PRK12296
1048245007517	GTP1/OBG; Region: GTP1_OBG; pfam01018
1048245007518	Obg GTPase; Region: Obg; cd01898
1048245007519	G1 box; other site
1048245007520	GTP/Mg2+ binding site [chemical binding]; other site
1048245007521	Switch I region; other site
1048245007522	G2 box; other site
1048245007523	G3 box; other site
1048245007524	Switch II region; other site
1048245007525	G4 box; other site
1048245007526	G5 box; other site
1048245007527	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1048245007529	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1048245007531	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1048245007532	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1048245007533	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1048245007534	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1048245007535	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1048245007536	homodimer interface [polypeptide binding]; other site
1048245007537	oligonucleotide binding site [chemical binding]; other site
1048245007538	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1048245007539	active site
1048245007540	multimer interface [polypeptide binding]; other site
1048245007541	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
1048245007542	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1048245007543	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1048245007545	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1048245007546	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1048245007547	active site
1048245007548	HIGH motif; other site
1048245007549	nucleotide binding site [chemical binding]; other site
1048245007550	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1048245007551	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1048245007552	active site
1048245007553	KMSKS motif; other site
1048245007554	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1048245007555	tRNA binding surface [nucleotide binding]; other site
1048245007556	anticodon binding site; other site
1048245007557	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1048245007559	Uncharacterized conserved protein [Function unknown]; Region: COG3268
1048245007560	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1048245007561	NAD(P) binding pocket [chemical binding]; other site
1048245007562	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1048245007563	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1048245007564	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1048245007565	GTP binding site; other site
1048245007566	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
1048245007567	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1048245007568	TPP-binding site [chemical binding]; other site
1048245007569	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1048245007570	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
1048245007571	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1048245007572	dimer interface [polypeptide binding]; other site
1048245007573	PYR/PP interface [polypeptide binding]; other site
1048245007574	TPP binding site [chemical binding]; other site
1048245007575	substrate binding site [chemical binding]; other site
1048245007577	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1048245007578	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1048245007579	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245007580	Walker A motif; other site
1048245007581	ATP binding site [chemical binding]; other site
1048245007582	Walker B motif; other site
1048245007583	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1048245007585	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
1048245007586	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1048245007587	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245007588	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1048245007589	putative substrate translocation pore; other site
1048245007590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245007591	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
1048245007592	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1048245007593	oligomer interface [polypeptide binding]; other site
1048245007594	active site residues [active]
1048245007596	Clp protease; Region: CLP_protease; pfam00574
1048245007597	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1048245007598	oligomer interface [polypeptide binding]; other site
1048245007599	active site residues [active]
1048245007600	trigger factor; Provisional; Region: tig; PRK01490
1048245007601	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1048245007602	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1048245007603	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1048245007604	Beta-lactamase; Region: Beta-lactamase; pfam00144
1048245007605	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1048245007606	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
1048245007607	putative DNA binding site [nucleotide binding]; other site
1048245007608	catalytic residue [active]
1048245007609	putative H2TH interface [polypeptide binding]; other site
1048245007610	putative catalytic residues [active]
1048245007611	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1048245007612	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1048245007613	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1048245007614	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1048245007615	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1048245007617	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
1048245007618	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
1048245007619	Zn binding site [ion binding]; other site
1048245007621	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1048245007622	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245007623	active site
1048245007624	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1048245007625	apolar tunnel; other site
1048245007626	heme binding site [chemical binding]; other site
1048245007627	dimerization interface [polypeptide binding]; other site
1048245007628	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
1048245007629	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1048245007630	active site
1048245007631	catalytic site [active]
1048245007632	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1048245007633	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1048245007634	active site
1048245007635	NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902
1048245007636	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1048245007637	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1048245007638	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1048245007639	ABC transporter; Region: ABC_tran_2; pfam12848
1048245007640	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1048245007645	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1048245007646	dimer interface [polypeptide binding]; other site
1048245007647	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1048245007648	ssDNA binding site [nucleotide binding]; other site
1048245007649	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1048245007650	glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355
1048245007651	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
1048245007652	putative acyl-acceptor binding pocket; other site
1048245007653	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1048245007654	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
1048245007655	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1048245007656	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1048245007657	putative acyl-acceptor binding pocket; other site
1048245007658	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1048245007659	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1048245007660	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1048245007661	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1048245007662	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1048245007663	enoyl-CoA hydratase; Provisional; Region: PRK05870
1048245007664	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245007665	substrate binding site [chemical binding]; other site
1048245007666	oxyanion hole (OAH) forming residues; other site
1048245007667	trimer interface [polypeptide binding]; other site
1048245007669	Transposase [DNA replication, recombination, and repair]; Region: COG5421
1048245007670	PE family; Region: PE; pfam00934
1048245007671	PE family; Region: PE; pfam00934
1048245007672	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1048245007673	cyclase homology domain; Region: CHD; cd07302
1048245007674	nucleotidyl binding site; other site
1048245007675	metal binding site [ion binding]; metal-binding site
1048245007676	dimer interface [polypeptide binding]; other site
1048245007677	Predicted ATPase [General function prediction only]; Region: COG3903
1048245007678	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1048245007679	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1048245007680	DNA binding residues [nucleotide binding]
1048245007681	dimerization interface [polypeptide binding]; other site
1048245007684	PE family; Region: PE; pfam00934
1048245007685	TIGR00725 family protein; Region: TIGR00725
1048245007686	thymidylate synthase; Provisional; Region: thyA; PRK00956
1048245007687	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1048245007688	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1048245007689	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1048245007690	E3 interaction surface; other site
1048245007691	lipoyl attachment site [posttranslational modification]; other site
1048245007692	e3 binding domain; Region: E3_binding; pfam02817
1048245007693	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1048245007694	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1048245007695	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1048245007696	alpha subunit interface [polypeptide binding]; other site
1048245007697	TPP binding site [chemical binding]; other site
1048245007698	heterodimer interface [polypeptide binding]; other site
1048245007699	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1048245007700	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1048245007701	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1048245007702	tetramer interface [polypeptide binding]; other site
1048245007703	TPP-binding site [chemical binding]; other site
1048245007704	heterodimer interface [polypeptide binding]; other site
1048245007705	phosphorylation loop region [posttranslational modification]
1048245007706	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1048245007707	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1048245007708	putative active site [active]
1048245007709	putative catalytic site [active]
1048245007710	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245007711	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245007712	active site
1048245007715	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1048245007716	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1048245007717	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1048245007718	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1048245007719	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1048245007720	carboxyltransferase (CT) interaction site; other site
1048245007721	biotinylation site [posttranslational modification]; other site
1048245007725	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1048245007726	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1048245007727	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1048245007728	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1048245007729	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1048245007730	AMP-binding domain protein; Validated; Region: PRK08315
1048245007731	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245007732	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1048245007733	acyl-activating enzyme (AAE) consensus motif; other site
1048245007734	acyl-activating enzyme (AAE) consensus motif; other site
1048245007735	putative AMP binding site [chemical binding]; other site
1048245007736	putative active site [active]
1048245007737	putative CoA binding site [chemical binding]; other site
1048245007738	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245007739	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245007740	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
1048245007741	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1048245007742	classical (c) SDRs; Region: SDR_c; cd05233
1048245007743	NAD(P) binding site [chemical binding]; other site
1048245007744	active site
1048245007746	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1048245007748	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1048245007749	catalytic site [active]
1048245007750	putative active site [active]
1048245007751	putative substrate binding site [chemical binding]; other site
1048245007752	dimer interface [polypeptide binding]; other site
1048245007753	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1048245007754	MULE transposase domain; Region: MULE; pfam10551
1048245007755	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1048245007756	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245007757	Walker A motif; other site
1048245007758	ATP binding site [chemical binding]; other site
1048245007759	Walker B motif; other site
1048245007760	Integrase core domain; Region: rve; pfam00665
1048245007761	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1048245007762	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
1048245007763	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1048245007764	non-specific DNA binding site [nucleotide binding]; other site
1048245007765	salt bridge; other site
1048245007766	sequence-specific DNA binding site [nucleotide binding]; other site
1048245007767	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
1048245007769	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893
1048245007770	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1048245007771	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
1048245007772	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1048245007773	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1048245007775	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1048245007776	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1048245007777	catalytic triad [active]
1048245007778	hypothetical protein; Provisional; Region: PRK07907
1048245007779	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
1048245007780	active site
1048245007781	metal binding site [ion binding]; metal-binding site
1048245007782	dimer interface [polypeptide binding]; other site
1048245007783	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1048245007784	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1048245007785	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
1048245007786	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1048245007787	phosphate binding site [ion binding]; other site
1048245007788	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
1048245007789	FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit.  Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447
1048245007790	putative active site [active]
1048245007791	putative catalytic site [active]
1048245007792	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1048245007793	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1048245007794	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
1048245007795	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
1048245007796	putative NAD(P) binding site [chemical binding]; other site
1048245007797	active site
1048245007798	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
1048245007799	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1048245007800	active site
1048245007803	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
1048245007804	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1048245007805	putative active site [active]
1048245007806	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
1048245007807	Mrr N-terminal domain; Region: Mrr_N; pfam14338
1048245007808	Restriction endonuclease; Region: Mrr_cat; pfam04471
1048245007809	ERCC4 domain; Region: ERCC4; pfam02732
1048245007810	Lsr2; Region: Lsr2; pfam11774
1048245007811	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1048245007812	putative active site [active]
1048245007813	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1048245007814	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1048245007815	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1048245007816	catalytic residue [active]
1048245007817	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1048245007818	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1048245007819	putative RNA binding site [nucleotide binding]; other site
1048245007820	elongation factor P; Validated; Region: PRK00529
1048245007821	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1048245007822	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1048245007823	RNA binding site [nucleotide binding]; other site
1048245007824	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1048245007825	RNA binding site [nucleotide binding]; other site
1048245007826	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1048245007827	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1048245007828	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1048245007829	active site
1048245007830	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1048245007831	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1048245007832	trimer interface [polypeptide binding]; other site
1048245007833	active site
1048245007834	dimer interface [polypeptide binding]; other site
1048245007836	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1048245007837	active site
1048245007838	dimer interface [polypeptide binding]; other site
1048245007839	metal binding site [ion binding]; metal-binding site
1048245007840	shikimate kinase; Reviewed; Region: aroK; PRK00131
1048245007841	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1048245007842	ADP binding site [chemical binding]; other site
1048245007843	magnesium binding site [ion binding]; other site
1048245007844	putative shikimate binding site; other site
1048245007847	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1048245007848	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1048245007849	Tetramer interface [polypeptide binding]; other site
1048245007850	active site
1048245007851	FMN-binding site [chemical binding]; other site
1048245007853	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
1048245007855	digalactosyldiacylglycerol synthase; Region: PLN02846
1048245007856	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1048245007857	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1048245007858	putative active site [active]
1048245007859	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1048245007860	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1048245007861	oligomeric interface; other site
1048245007862	putative active site [active]
1048245007863	homodimer interface [polypeptide binding]; other site
1048245007864	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
1048245007865	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1048245007866	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1048245007867	shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809
1048245007868	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1048245007869	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1048245007870	NAD(P) binding site [chemical binding]; other site
1048245007871	shikimate binding site; other site
1048245007872	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
1048245007873	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1048245007874	dimerization interface [polypeptide binding]; other site
1048245007875	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1048245007876	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1048245007877	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1048245007878	motif 1; other site
1048245007879	active site
1048245007880	motif 2; other site
1048245007881	motif 3; other site
1048245007882	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1048245007883	DHHA1 domain; Region: DHHA1; pfam02272
1048245007884	Uncharacterized conserved protein [Function unknown]; Region: COG0432
1048245007885	recombination factor protein RarA; Reviewed; Region: PRK13342
1048245007886	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245007887	Walker A motif; other site
1048245007888	ATP binding site [chemical binding]; other site
1048245007889	Walker B motif; other site
1048245007890	arginine finger; other site
1048245007891	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1048245007893	Predicted integral membrane protein [Function unknown]; Region: COG5473
1048245007894	Protein of unknown function (DUF2652); Region: DUF2652; pfam10851
1048245007895	Protein of unknown function (DUF2652); Region: DUF2652; pfam10851
1048245007896	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1048245007897	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1048245007898	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1048245007899	Walker A/P-loop; other site
1048245007900	ATP binding site [chemical binding]; other site
1048245007901	Q-loop/lid; other site
1048245007902	ABC transporter signature motif; other site
1048245007903	Walker B; other site
1048245007904	D-loop; other site
1048245007905	H-loop/switch region; other site
1048245007906	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1048245007907	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1048245007908	ligand binding site [chemical binding]; other site
1048245007909	flexible hinge region; other site
1048245007913	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1048245007914	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1048245007915	ligand binding site [chemical binding]; other site
1048245007916	flexible hinge region; other site
1048245007917	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1048245007918	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
1048245007919	active site
1048245007920	nucleophile elbow; other site
1048245007921	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1048245007922	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1048245007923	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1048245007924	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
1048245007925	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
1048245007926	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1048245007927	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1048245007928	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1048245007929	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
1048245007930	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
1048245007931	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1048245007932	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1048245007933	Transglutaminase/protease-like homologues; Region: TGc; smart00460
1048245007934	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801
1048245007935	Predicted membrane protein [Function unknown]; Region: COG4129
1048245007936	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1048245007937	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1048245007938	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1048245007939	dimer interface [polypeptide binding]; other site
1048245007940	anticodon binding site; other site
1048245007941	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1048245007942	homodimer interface [polypeptide binding]; other site
1048245007943	motif 1; other site
1048245007944	active site
1048245007945	motif 2; other site
1048245007946	GAD domain; Region: GAD; pfam02938
1048245007947	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1048245007948	active site
1048245007949	motif 3; other site
1048245007951	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1048245007952	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1048245007953	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1048245007954	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1048245007955	putative hydrophobic ligand binding site [chemical binding]; other site
1048245007956	protein interface [polypeptide binding]; other site
1048245007957	gate; other site
1048245007958	Predicted metalloprotease [General function prediction only]; Region: COG2321
1048245007959	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1048245007961	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1048245007962	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1048245007963	active site
1048245007964	metal binding site [ion binding]; metal-binding site
1048245007965	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1048245007966	haloalkane dehalogenase; Provisional; Region: PRK03592
1048245007967	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1048245007968	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1048245007969	dimer interface [polypeptide binding]; other site
1048245007970	motif 1; other site
1048245007971	active site
1048245007972	motif 2; other site
1048245007973	motif 3; other site
1048245007974	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1048245007975	anticodon binding site; other site
1048245007977	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1048245007978	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1048245007979	active site
1048245007980	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
1048245007981	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1048245007982	Zn2+ binding site [ion binding]; other site
1048245007983	Mg2+ binding site [ion binding]; other site
1048245007984	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1048245007985	synthetase active site [active]
1048245007986	NTP binding site [chemical binding]; other site
1048245007987	metal binding site [ion binding]; metal-binding site
1048245007988	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1048245007989	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1048245007990	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1048245007991	active site
1048245007994	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1048245007995	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1048245007996	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1048245007997	Protein export membrane protein; Region: SecD_SecF; pfam02355
1048245007998	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1048245007999	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1048245008000	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886
1048245008001	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
1048245008002	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1048245008003	inhibitor-cofactor binding pocket; inhibition site
1048245008004	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245008005	catalytic residue [active]
1048245008007	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1048245008008	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245008009	acyl-activating enzyme (AAE) consensus motif; other site
1048245008010	AMP binding site [chemical binding]; other site
1048245008011	active site
1048245008012	CoA binding site [chemical binding]; other site
1048245008013	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
1048245008014	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1048245008015	putative NAD(P) binding site [chemical binding]; other site
1048245008016	active site
1048245008017	putative substrate binding site [chemical binding]; other site
1048245008020	PE family; Region: PE; pfam00934
1048245008021	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1048245008022	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245008023	Walker A motif; other site
1048245008024	ATP binding site [chemical binding]; other site
1048245008025	Walker B motif; other site
1048245008026	arginine finger; other site
1048245008027	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1048245008029	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1048245008030	RuvA N terminal domain; Region: RuvA_N; pfam01330
1048245008031	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1048245008032	active site
1048245008033	putative DNA-binding cleft [nucleotide binding]; other site
1048245008034	dimer interface [polypeptide binding]; other site
1048245008035	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1048245008036	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
1048245008037	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1048245008038	putative active site [active]
1048245008039	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
1048245008040	Protein of unknown function DUF2617; Region: DUF2617; pfam10936
1048245008041	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
1048245008043	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1048245008044	Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262
1048245008045	Spermine/spermidine synthase; Region: Spermine_synth; pfam01564
1048245008046	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
1048245008047	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1048245008048	hypothetical protein; Validated; Region: PRK00110
1048245008049	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1048245008050	predicted active site [active]
1048245008051	catalytic triad [active]
1048245008052	acyl-CoA thioesterase II; Region: tesB; TIGR00189
1048245008053	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1048245008054	active site
1048245008055	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1048245008056	catalytic triad [active]
1048245008057	dimer interface [polypeptide binding]; other site
1048245008058	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1048245008059	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1048245008060	active site
1048245008061	multimer interface [polypeptide binding]; other site
1048245008062	Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259
1048245008063	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1048245008064	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1048245008065	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245008066	PPE family; Region: PPE; pfam00823
1048245008067	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245008068	PE-PPE domain; Region: PE-PPE; pfam08237
1048245008069	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
1048245008070	nudix motif; other site
1048245008072	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1048245008073	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1048245008075	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1048245008076	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1048245008077	putative acyl-acceptor binding pocket; other site
1048245008078	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1048245008080	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
1048245008081	nucleotide binding site/active site [active]
1048245008082	HIT family signature motif; other site
1048245008083	catalytic residue [active]
1048245008084	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
1048245008085	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1048245008086	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1048245008087	active site
1048245008088	dimer interface [polypeptide binding]; other site
1048245008089	motif 1; other site
1048245008090	motif 2; other site
1048245008091	motif 3; other site
1048245008092	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1048245008093	anticodon binding site; other site
1048245008095	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1048245008096	phosphate binding site [ion binding]; other site
1048245008097	PE family; Region: PE; pfam00934
1048245008098	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762
1048245008099	Predicted transcriptional regulator [Transcription]; Region: COG2345
1048245008100	Helix-turn-helix domain; Region: HTH_20; pfam12840
1048245008101	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1048245008102	Predicted transcriptional regulator [Transcription]; Region: COG2345
1048245008103	Helix-turn-helix domain; Region: HTH_20; pfam12840
1048245008104	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245008105	S-adenosylmethionine binding site [chemical binding]; other site
1048245008106	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1048245008107	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1048245008108	Ligand Binding Site [chemical binding]; other site
1048245008109	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1048245008110	Ligand Binding Site [chemical binding]; other site
1048245008111	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1048245008112	Ligand Binding Site [chemical binding]; other site
1048245008113	Universal stress protein family; Region: Usp; pfam00582
1048245008114	Ligand Binding Site [chemical binding]; other site
1048245008115	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
1048245008116	active site
1048245008117	Peptidase family M50; Region: Peptidase_M50; pfam02163
1048245008118	putative substrate binding region [chemical binding]; other site
1048245008119	FOG: CBS domain [General function prediction only]; Region: COG0517
1048245008120	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
1048245008122	FOG: CBS domain [General function prediction only]; Region: COG0517
1048245008123	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1048245008124	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1048245008125	MULE transposase domain; Region: MULE; pfam10551
1048245008126	peptide chain release factor 1; Provisional; Region: PRK04011
1048245008127	SHS2 domain protein implicated in nucleic acid metabolism [General function prediction    only]; Region: COG1371
1048245008128	Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690
1048245008129	hypothetical protein; Reviewed; Region: PRK09588
1048245008130	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
1048245008131	Hemerythrin-like domain; Region: Hr-like; cd12108
1048245008132	Fe binding site [ion binding]; other site
1048245008133	PE family; Region: PE; pfam00934
1048245008134	Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227
1048245008135	P-loop motif; other site
1048245008136	ATP binding site [chemical binding]; other site
1048245008137	Chloramphenicol (Cm) binding site [chemical binding]; other site
1048245008138	catalytic residue [active]
1048245008140	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1048245008141	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1048245008142	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1048245008143	anti sigma factor interaction site; other site
1048245008144	regulatory phosphorylation site [posttranslational modification]; other site
1048245008145	hypothetical protein; Provisional; Region: PRK02237
1048245008146	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1048245008147	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1048245008148	putative DNA binding site [nucleotide binding]; other site
1048245008149	putative Zn2+ binding site [ion binding]; other site
1048245008150	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
1048245008151	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1048245008152	putative metal binding site [ion binding]; other site
1048245008153	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1048245008154	dimerization interface [polypeptide binding]; other site
1048245008155	putative DNA binding site [nucleotide binding]; other site
1048245008156	putative Zn2+ binding site [ion binding]; other site
1048245008158	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1048245008159	arsenical-resistance protein; Region: acr3; TIGR00832
1048245008160	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1048245008161	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1048245008162	active site
1048245008163	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1048245008164	MULE transposase domain; Region: MULE; pfam10551
1048245008165	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1048245008166	Clp amino terminal domain; Region: Clp_N; pfam02861
1048245008167	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1048245008168	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1048245008169	Coenzyme A binding pocket [chemical binding]; other site
1048245008170	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
1048245008172	hypothetical protein; Provisional; Region: PRK14059
1048245008173	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
1048245008174	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245008175	TAP-like protein; Region: Abhydrolase_4; pfam08386
1048245008176	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1048245008177	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
1048245008178	SelR domain; Region: SelR; pfam01641
1048245008179	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1048245008180	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245008181	S-adenosylmethionine binding site [chemical binding]; other site
1048245008182	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
1048245008183	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1048245008184	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1048245008185	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1048245008186	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1048245008187	substrate binding site [chemical binding]; other site
1048245008188	active site
1048245008190	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245008191	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1048245008192	substrate binding site [chemical binding]; other site
1048245008193	oxyanion hole (OAH) forming residues; other site
1048245008194	trimer interface [polypeptide binding]; other site
1048245008196	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
1048245008197	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1048245008198	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1048245008199	catalytic site [active]
1048245008200	putative active site [active]
1048245008201	putative substrate binding site [chemical binding]; other site
1048245008202	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
1048245008203	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1048245008204	TPP-binding site; other site
1048245008205	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1048245008206	PYR/PP interface [polypeptide binding]; other site
1048245008207	dimer interface [polypeptide binding]; other site
1048245008208	TPP binding site [chemical binding]; other site
1048245008209	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1048245008210	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1048245008211	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1048245008212	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1048245008213	transmembrane helices; other site
1048245008214	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1048245008215	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1048245008216	transmembrane helices; other site
1048245008218	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1048245008219	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1048245008220	Walker A/P-loop; other site
1048245008221	ATP binding site [chemical binding]; other site
1048245008222	Q-loop/lid; other site
1048245008223	ABC transporter signature motif; other site
1048245008224	Walker B; other site
1048245008225	D-loop; other site
1048245008226	H-loop/switch region; other site
1048245008228	TRAM domain; Region: TRAM; cl01282
1048245008229	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1048245008230	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245008231	S-adenosylmethionine binding site [chemical binding]; other site
1048245008232	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1048245008233	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1048245008234	TrkA-N domain; Region: TrkA_N; pfam02254
1048245008235	TrkA-C domain; Region: TrkA_C; pfam02080
1048245008236	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1048245008237	TrkA-N domain; Region: TrkA_N; pfam02254
1048245008238	TrkA-C domain; Region: TrkA_C; pfam02080
1048245008239	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
1048245008240	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1048245008241	generic binding surface II; other site
1048245008242	ssDNA binding site; other site
1048245008243	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
1048245008244	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1048245008245	trimer interface [polypeptide binding]; other site
1048245008246	active site
1048245008247	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
1048245008248	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
1048245008249	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1048245008250	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1048245008251	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1048245008252	active site
1048245008253	dimerization interface [polypeptide binding]; other site
1048245008256	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1048245008257	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1048245008258	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1048245008259	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1048245008260	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1048245008261	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1048245008262	DNA binding residues [nucleotide binding]
1048245008264	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
1048245008265	homotrimer interaction site [polypeptide binding]; other site
1048245008266	putative active site [active]
1048245008267	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
1048245008268	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
1048245008269	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
1048245008270	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
1048245008271	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1048245008272	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1048245008273	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1048245008274	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1048245008275	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1048245008276	DNA binding residues [nucleotide binding]
1048245008278	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1048245008279	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1048245008280	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1048245008281	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
1048245008283	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
1048245008284	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
1048245008285	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1048245008286	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1048245008287	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1048245008289	PAC2 family; Region: PAC2; pfam09754
1048245008290	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245008291	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1048245008293	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1048245008294	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
1048245008295	heme-binding site [chemical binding]; other site
1048245008296	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1048245008297	ATP cone domain; Region: ATP-cone; pfam03477
1048245008298	LysM domain; Region: LysM; pfam01476
1048245008299	LexA repressor; Validated; Region: PRK00215
1048245008300	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1048245008301	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1048245008302	Catalytic site [active]
1048245008303	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1048245008304	LGFP repeat; Region: LGFP; pfam08310
1048245008305	LGFP repeat; Region: LGFP; pfam08310
1048245008306	LGFP repeat; Region: LGFP; pfam08310
1048245008307	LGFP repeat; Region: LGFP; pfam08310
1048245008308	LGFP repeat; Region: LGFP; pfam08310
1048245008309	Integral membrane protein TerC family; Region: TerC; cl10468
1048245008310	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245008311	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245008312	active site
1048245008314	GTPases [General function prediction only]; Region: HflX; COG2262
1048245008315	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1048245008316	HflX GTPase family; Region: HflX; cd01878
1048245008317	G1 box; other site
1048245008318	GTP/Mg2+ binding site [chemical binding]; other site
1048245008319	Switch I region; other site
1048245008320	G2 box; other site
1048245008321	G3 box; other site
1048245008322	Switch II region; other site
1048245008323	G4 box; other site
1048245008324	G5 box; other site
1048245008326	diaminopimelate epimerase; Region: DapF; TIGR00652
1048245008327	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1048245008328	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1048245008329	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1048245008330	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1048245008332	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
1048245008333	active site
1048245008334	metal binding site [ion binding]; metal-binding site
1048245008335	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1048245008336	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1048245008337	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1048245008338	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
1048245008339	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1048245008340	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1048245008341	FeS/SAM binding site; other site
1048245008342	TRAM domain; Region: TRAM; cl01282
1048245008343	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1048245008344	FeS/SAM binding site; other site
1048245008346	Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137
1048245008347	DNA recombination protein RecA; Reviewed; Region: recA; PRK09519
1048245008348	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1048245008349	hexamer interface [polypeptide binding]; other site
1048245008350	Walker A motif; other site
1048245008351	ATP binding site [chemical binding]; other site
1048245008352	Walker B motif; other site
1048245008353	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1048245008354	protein-splicing catalytic site; other site
1048245008355	thioester formation/cholesterol transfer; other site
1048245008356	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
1048245008357	recA bacterial DNA recombination protein; Region: RecA; cl17211
1048245008360	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1048245008361	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
1048245008362	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1048245008363	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1048245008364	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1048245008365	PE family; Region: PE; pfam00934
1048245008366	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
1048245008367	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1048245008368	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1048245008369	non-specific DNA binding site [nucleotide binding]; other site
1048245008370	salt bridge; other site
1048245008371	sequence-specific DNA binding site [nucleotide binding]; other site
1048245008372	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1048245008374	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1048245008375	Coenzyme A binding pocket [chemical binding]; other site
1048245008376	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1048245008377	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1048245008378	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1048245008380	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1048245008381	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
1048245008382	classical (c) SDRs; Region: SDR_c; cd05233
1048245008383	NAD(P) binding site [chemical binding]; other site
1048245008384	active site
1048245008385	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1048245008386	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1048245008387	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1048245008388	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1048245008389	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1048245008390	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1048245008391	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1048245008392	dimer interface [polypeptide binding]; other site
1048245008393	active site
1048245008394	catalytic residue [active]
1048245008397	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
1048245008398	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1048245008399	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1048245008400	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1048245008401	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1048245008402	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1048245008403	putative active site [active]
1048245008404	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1048245008406	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
1048245008407	putative active site [active]
1048245008408	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
1048245008409	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1048245008410	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1048245008411	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
1048245008412	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1048245008413	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1048245008414	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1048245008415	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1048245008416	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1048245008417	folate binding site [chemical binding]; other site
1048245008418	NADP+ binding site [chemical binding]; other site
1048245008420	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1048245008421	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1048245008422	dimerization interface [polypeptide binding]; other site
1048245008423	active site
1048245008425	Dienelactone hydrolase family; Region: DLH; pfam01738
1048245008426	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
1048245008427	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1048245008428	classical (c) SDRs; Region: SDR_c; cd05233
1048245008429	NAD(P) binding site [chemical binding]; other site
1048245008430	active site
1048245008432	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245008433	PPE family; Region: PPE; pfam00823
1048245008434	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245008435	PE family; Region: PE; pfam00934
1048245008436	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245008437	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245008438	PPE family; Region: PPE; pfam00823
1048245008439	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1048245008440	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1048245008441	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1048245008442	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1048245008443	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1048245008444	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1048245008445	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1048245008446	Coenzyme A binding pocket [chemical binding]; other site
1048245008447	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1048245008448	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1048245008449	FMN-binding pocket [chemical binding]; other site
1048245008450	flavin binding motif; other site
1048245008451	phosphate binding motif [ion binding]; other site
1048245008452	beta-alpha-beta structure motif; other site
1048245008453	NAD binding pocket [chemical binding]; other site
1048245008454	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1048245008455	catalytic loop [active]
1048245008456	iron binding site [ion binding]; other site
1048245008459	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1048245008460	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
1048245008461	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1048245008462	hydrophobic ligand binding site; other site
1048245008463	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1048245008464	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1048245008465	putative DNA binding site [nucleotide binding]; other site
1048245008466	putative Zn2+ binding site [ion binding]; other site
1048245008467	AsnC family; Region: AsnC_trans_reg; pfam01037
1048245008468	alanine dehydrogenase; Region: alaDH; TIGR00518
1048245008469	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1048245008470	hexamer interface [polypeptide binding]; other site
1048245008471	ligand binding site [chemical binding]; other site
1048245008472	putative active site [active]
1048245008473	NAD(P) binding site [chemical binding]; other site
1048245008476	Nitronate monooxygenase; Region: NMO; pfam03060
1048245008477	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1048245008478	FMN binding site [chemical binding]; other site
1048245008479	substrate binding site [chemical binding]; other site
1048245008480	putative catalytic residue [active]
1048245008481	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1048245008482	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1048245008483	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1048245008485	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
1048245008486	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
1048245008487	oligomer interface [polypeptide binding]; other site
1048245008488	RNA binding site [nucleotide binding]; other site
1048245008489	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1048245008490	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1048245008491	RNase E interface [polypeptide binding]; other site
1048245008492	trimer interface [polypeptide binding]; other site
1048245008493	active site
1048245008494	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1048245008495	putative nucleic acid binding region [nucleotide binding]; other site
1048245008496	G-X-X-G motif; other site
1048245008497	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1048245008498	RNA binding site [nucleotide binding]; other site
1048245008499	domain interface; other site
1048245008501	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1048245008502	16S/18S rRNA binding site [nucleotide binding]; other site
1048245008503	S13e-L30e interaction site [polypeptide binding]; other site
1048245008504	25S rRNA binding site [nucleotide binding]; other site
1048245008506	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1048245008507	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1048245008508	active site
1048245008509	Riboflavin kinase; Region: Flavokinase; pfam01687
1048245008510	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1048245008511	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1048245008513	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1048245008514	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1048245008515	putative DNA binding site [nucleotide binding]; other site
1048245008516	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1048245008517	FeoA domain; Region: FeoA; pfam04023
1048245008518	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245008519	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245008520	active site
1048245008522	lipid-transfer protein; Provisional; Region: PRK08256
1048245008523	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1048245008524	active site
1048245008527	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
1048245008528	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1048245008529	RNA binding site [nucleotide binding]; other site
1048245008530	active site
1048245008531	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
1048245008532	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
1048245008533	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1048245008534	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1048245008535	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1048245008536	active site
1048245008537	metal binding site [ion binding]; metal-binding site
1048245008538	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1048245008541	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1048245008542	Predicted acyl esterases [General function prediction only]; Region: COG2936
1048245008543	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
1048245008544	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1048245008545	Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373
1048245008546	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
1048245008548	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1048245008549	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1048245008550	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1048245008551	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1048245008552	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1048245008553	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
1048245008554	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636
1048245008555	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699
1048245008556	CRISPR system related protein, RAMP superfamily [Defense mechanisms]; Region: COG1332
1048245008557	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
1048245008558	CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684
1048245008559	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647
1048245008560	Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353
1048245008561	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
1048245008563	Integrase core domain; Region: rve; pfam00665
1048245008564	Domain of unknown function (DUF1802); Region: DUF1802; cl01755
1048245008565	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1048245008566	putative active site [active]
1048245008567	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1048245008568	enoyl-CoA hydratase; Provisional; Region: PRK06190
1048245008569	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245008570	substrate binding site [chemical binding]; other site
1048245008571	oxyanion hole (OAH) forming residues; other site
1048245008572	trimer interface [polypeptide binding]; other site
1048245008573	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1048245008574	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1048245008575	Walker A/P-loop; other site
1048245008576	ATP binding site [chemical binding]; other site
1048245008577	Q-loop/lid; other site
1048245008578	ABC transporter signature motif; other site
1048245008579	Walker B; other site
1048245008580	D-loop; other site
1048245008581	H-loop/switch region; other site
1048245008584	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1048245008585	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1048245008586	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1048245008587	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245008588	dimer interface [polypeptide binding]; other site
1048245008589	conserved gate region; other site
1048245008590	putative PBP binding loops; other site
1048245008591	ABC-ATPase subunit interface; other site
1048245008593	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1048245008594	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245008595	dimer interface [polypeptide binding]; other site
1048245008596	conserved gate region; other site
1048245008597	putative PBP binding loops; other site
1048245008598	ABC-ATPase subunit interface; other site
1048245008601	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1048245008602	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1048245008604	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1048245008605	DHH family; Region: DHH; pfam01368
1048245008606	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1048245008607	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1048245008608	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1048245008609	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
1048245008610	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1048245008611	G1 box; other site
1048245008612	putative GEF interaction site [polypeptide binding]; other site
1048245008613	GTP/Mg2+ binding site [chemical binding]; other site
1048245008614	Switch I region; other site
1048245008615	G2 box; other site
1048245008616	G3 box; other site
1048245008617	Switch II region; other site
1048245008618	G4 box; other site
1048245008619	G5 box; other site
1048245008620	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1048245008621	Translation-initiation factor 2; Region: IF-2; pfam11987
1048245008622	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1048245008624	Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740
1048245008625	putative RNA binding cleft [nucleotide binding]; other site
1048245008626	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1048245008627	NusA N-terminal domain; Region: NusA_N; pfam08529
1048245008628	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1048245008629	RNA binding site [nucleotide binding]; other site
1048245008630	homodimer interface [polypeptide binding]; other site
1048245008631	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1048245008632	G-X-X-G motif; other site
1048245008633	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1048245008634	G-X-X-G motif; other site
1048245008635	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1048245008636	Sm and related proteins; Region: Sm_like; cl00259
1048245008637	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1048245008638	putative oligomer interface [polypeptide binding]; other site
1048245008639	putative RNA binding site [nucleotide binding]; other site
1048245008640	Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718
1048245008641	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1048245008642	dinuclear metal binding motif [ion binding]; other site
1048245008643	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1048245008644	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1048245008645	dimer interface [polypeptide binding]; other site
1048245008646	motif 1; other site
1048245008647	active site
1048245008648	motif 2; other site
1048245008649	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
1048245008650	putative deacylase active site [active]
1048245008651	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1048245008652	active site
1048245008653	motif 3; other site
1048245008654	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1048245008655	anticodon binding site; other site
1048245008657	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245008658	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1048245008659	putative substrate translocation pore; other site
1048245008660	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
1048245008661	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1048245008662	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1048245008663	homodimer interface [polypeptide binding]; other site
1048245008664	active site
1048245008665	SAM binding site [chemical binding]; other site
1048245008666	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1048245008667	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1048245008668	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1048245008669	catalytic triad [active]
1048245008670	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1048245008671	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1048245008672	homodimer interface [polypeptide binding]; other site
1048245008673	Walker A motif; other site
1048245008674	ATP binding site [chemical binding]; other site
1048245008675	hydroxycobalamin binding site [chemical binding]; other site
1048245008676	Walker B motif; other site
1048245008677	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
1048245008678	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245008679	Walker A motif; other site
1048245008680	ATP binding site [chemical binding]; other site
1048245008681	Walker B motif; other site
1048245008682	arginine finger; other site
1048245008683	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
1048245008684	metal ion-dependent adhesion site (MIDAS); other site
1048245008685	Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153
1048245008686	malate:quinone oxidoreductase; Validated; Region: PRK05257
1048245008687	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1048245008688	PE family; Region: PE; pfam00934
1048245008689	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1048245008690	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1048245008691	mycothione reductase; Reviewed; Region: PRK07846
1048245008692	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1048245008693	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1048245008694	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1048245008695	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
1048245008696	short chain dehydrogenase; Provisional; Region: PRK06057
1048245008697	classical (c) SDRs; Region: SDR_c; cd05233
1048245008698	NAD(P) binding site [chemical binding]; other site
1048245008699	active site
1048245008700	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1048245008701	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1048245008702	NAD(P) binding site [chemical binding]; other site
1048245008703	catalytic residues [active]
1048245008706	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1048245008707	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1048245008708	catalytic triad [active]
1048245008709	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1048245008710	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1048245008711	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1048245008712	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1048245008713	active site
1048245008714	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1048245008715	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1048245008716	putative active site [active]
1048245008717	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1048245008718	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1048245008719	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1048245008722	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1048245008723	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1048245008724	Predicted acetyltransferase [General function prediction only]; Region: COG3393
1048245008725	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
1048245008726	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1048245008727	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1048245008728	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1048245008729	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1048245008730	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1048245008731	active site
1048245008732	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1048245008733	protein binding site [polypeptide binding]; other site
1048245008734	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1048245008735	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1048245008736	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1048245008737	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1048245008739	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1048245008740	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1048245008741	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
1048245008742	Fasciclin domain; Region: Fasciclin; pfam02469
1048245008744	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
1048245008745	Fasciclin domain; Region: Fasciclin; pfam02469
1048245008746	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
1048245008747	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1048245008749	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
1048245008750	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1048245008751	catalytic residues [active]
1048245008752	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
1048245008753	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1048245008754	FeS/SAM binding site; other site
1048245008755	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1048245008756	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1048245008758	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1048245008759	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1048245008760	hinge region; other site
1048245008761	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1048245008762	putative nucleotide binding site [chemical binding]; other site
1048245008763	uridine monophosphate binding site [chemical binding]; other site
1048245008764	homohexameric interface [polypeptide binding]; other site
1048245008765	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1048245008766	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1048245008767	DNA binding site [nucleotide binding]
1048245008770	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
1048245008771	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1048245008772	catalytic residues [active]
1048245008773	catalytic nucleophile [active]
1048245008775	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1048245008776	MarR family; Region: MarR; pfam01047
1048245008777	amidase; Provisional; Region: PRK07869
1048245008778	Amidase; Region: Amidase; pfam01425
1048245008780	elongation factor Ts; Provisional; Region: tsf; PRK09377
1048245008781	UBA/TS-N domain; Region: UBA; pfam00627
1048245008782	Elongation factor TS; Region: EF_TS; pfam00889
1048245008783	Elongation factor TS; Region: EF_TS; pfam00889
1048245008785	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1048245008786	rRNA interaction site [nucleotide binding]; other site
1048245008787	S8 interaction site; other site
1048245008788	putative laminin-1 binding site; other site
1048245008791	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1048245008792	Peptidase family M23; Region: Peptidase_M23; pfam01551
1048245008793	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245008794	PPE family; Region: PPE; pfam00823
1048245008795	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245008796	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
1048245008797	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1048245008798	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1048245008799	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1048245008800	active site
1048245008801	DNA binding site [nucleotide binding]
1048245008802	Int/Topo IB signature motif; other site
1048245008803	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1048245008804	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1048245008805	FAD binding pocket [chemical binding]; other site
1048245008806	FAD binding motif [chemical binding]; other site
1048245008807	phosphate binding motif [ion binding]; other site
1048245008808	NAD binding pocket [chemical binding]; other site
1048245008809	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1048245008810	DNA protecting protein DprA; Region: dprA; TIGR00732
1048245008811	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1048245008812	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1048245008813	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245008814	Walker A motif; other site
1048245008815	ATP binding site [chemical binding]; other site
1048245008816	Walker B motif; other site
1048245008817	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1048245008819	hypothetical protein; Reviewed; Region: PRK12497
1048245008820	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1048245008821	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1048245008822	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1048245008823	putative molybdopterin cofactor binding site [chemical binding]; other site
1048245008824	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1048245008825	putative molybdopterin cofactor binding site; other site
1048245008826	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
1048245008827	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1048245008828	RNA/DNA hybrid binding site [nucleotide binding]; other site
1048245008829	active site
1048245008830	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1048245008831	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1048245008832	Catalytic site [active]
1048245008833	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1048245008836	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1048245008837	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1048245008838	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1048245008839	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1048245008840	RimM N-terminal domain; Region: RimM; pfam01782
1048245008841	hypothetical protein; Provisional; Region: PRK02821
1048245008842	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1048245008843	G-X-X-G motif; other site
1048245008844	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
1048245008845	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
1048245008846	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1048245008847	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1048245008848	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245008849	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245008850	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
1048245008851	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
1048245008852	active site
1048245008853	putative substrate binding pocket [chemical binding]; other site
1048245008854	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1048245008855	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1048245008856	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1048245008857	active site
1048245008858	ATP binding site [chemical binding]; other site
1048245008859	substrate binding site [chemical binding]; other site
1048245008860	activation loop (A-loop); other site
1048245008861	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1048245008862	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
1048245008863	active site
1048245008864	signal recognition particle protein; Provisional; Region: PRK10867
1048245008865	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1048245008866	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1048245008867	P loop; other site
1048245008868	GTP binding site [chemical binding]; other site
1048245008869	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1048245008871	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1048245008872	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1048245008874	PII uridylyl-transferase; Provisional; Region: PRK03381
1048245008875	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1048245008876	metal binding triad; other site
1048245008877	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1048245008878	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1048245008879	Zn2+ binding site [ion binding]; other site
1048245008880	Mg2+ binding site [ion binding]; other site
1048245008881	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1048245008882	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1048245008883	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1048245008884	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
1048245008885	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1048245008886	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1048245008889	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1048245008890	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1048245008891	Walker A/P-loop; other site
1048245008892	ATP binding site [chemical binding]; other site
1048245008893	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1048245008894	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1048245008895	ABC transporter signature motif; other site
1048245008896	Walker B; other site
1048245008897	D-loop; other site
1048245008898	H-loop/switch region; other site
1048245008900	acylphosphatase; Provisional; Region: PRK14422
1048245008901	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
1048245008902	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1048245008903	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1048245008904	DNA binding site [nucleotide binding]
1048245008905	catalytic residue [active]
1048245008906	H2TH interface [polypeptide binding]; other site
1048245008907	putative catalytic residues [active]
1048245008908	turnover-facilitating residue; other site
1048245008909	intercalation triad [nucleotide binding]; other site
1048245008910	8OG recognition residue [nucleotide binding]; other site
1048245008911	putative reading head residues; other site
1048245008912	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1048245008913	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1048245008914	ribonuclease III; Reviewed; Region: rnc; PRK00102
1048245008915	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1048245008916	dimerization interface [polypeptide binding]; other site
1048245008917	active site
1048245008918	metal binding site [ion binding]; metal-binding site
1048245008919	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1048245008920	dsRNA binding site [nucleotide binding]; other site
1048245008922	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1048245008923	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1048245008924	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1048245008925	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1048245008926	acyl-CoA synthetase; Validated; Region: PRK05850
1048245008927	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1048245008928	acyl-activating enzyme (AAE) consensus motif; other site
1048245008929	active site
1048245008930	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1048245008931	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1048245008932	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245008933	active site
1048245008934	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
1048245008935	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1048245008936	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
1048245008937	NADP binding site [chemical binding]; other site
1048245008938	KR domain; Region: KR; pfam08659
1048245008939	active site
1048245008940	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245008943	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245008944	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1048245008945	active site
1048245008946	Acyl transferase domain; Region: Acyl_transf_1; cl08282
1048245008947	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
1048245008948	KR domain; Region: KR; pfam08659
1048245008949	NADP binding site [chemical binding]; other site
1048245008950	active site
1048245008951	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245008953	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1048245008954	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245008955	active site
1048245008956	Acyl transferase domain; Region: Acyl_transf_1; cl08282
1048245008957	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1048245008958	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245008959	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1048245008960	Enoylreductase; Region: PKS_ER; smart00829
1048245008961	NAD(P) binding site [chemical binding]; other site
1048245008962	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1048245008963	KR domain; Region: KR; pfam08659
1048245008964	putative NADP binding site [chemical binding]; other site
1048245008965	active site
1048245008966	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245008969	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1048245008970	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245008971	active site
1048245008972	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1048245008973	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1048245008974	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1048245008975	KR domain; Region: KR; pfam08659
1048245008976	putative NADP binding site [chemical binding]; other site
1048245008977	active site
1048245008978	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245008983	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1048245008984	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245008985	active site
1048245008986	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1048245008987	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1048245008988	Condensation domain; Region: Condensation; pfam00668
1048245008989	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1048245008991	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1048245008992	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1048245008993	Walker A/P-loop; other site
1048245008994	ATP binding site [chemical binding]; other site
1048245008995	Q-loop/lid; other site
1048245008996	ABC transporter signature motif; other site
1048245008997	Walker B; other site
1048245008998	D-loop; other site
1048245008999	H-loop/switch region; other site
1048245009002	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1048245009003	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
1048245009004	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
1048245009005	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1048245009006	acyltransferase PapA5; Provisional; Region: PRK09294
1048245009007	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1048245009008	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245009009	active site
1048245009010	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
1048245009011	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1048245009012	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245009013	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1048245009014	Enoylreductase; Region: PKS_ER; smart00829
1048245009015	NAD(P) binding site [chemical binding]; other site
1048245009016	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1048245009017	KR domain; Region: KR; pfam08659
1048245009018	putative NADP binding site [chemical binding]; other site
1048245009019	active site
1048245009020	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245009023	acyl-CoA synthetase; Validated; Region: PRK05850
1048245009024	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1048245009025	acyl-activating enzyme (AAE) consensus motif; other site
1048245009026	active site
1048245009028	MMPL family; Region: MMPL; pfam03176
1048245009032	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
1048245009034	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1048245009035	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1048245009036	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1048245009037	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245009038	Enoylreductase; Region: PKS_ER; smart00829
1048245009039	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1048245009040	NAD(P) binding site [chemical binding]; other site
1048245009041	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
1048245009042	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1048245009043	putative NADP binding site [chemical binding]; other site
1048245009044	active site
1048245009045	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245009047	Erythronolide synthase docking; Region: Docking; pfam08990
1048245009048	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245009049	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1048245009050	active site
1048245009052	acyl-CoA synthetase; Validated; Region: PRK06060
1048245009053	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245009054	acyl-activating enzyme (AAE) consensus motif; other site
1048245009055	AMP binding site [chemical binding]; other site
1048245009056	active site
1048245009057	CoA binding site [chemical binding]; other site
1048245009058	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245009059	4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161
1048245009060	acyl-CoA synthetase; Validated; Region: PRK05850
1048245009061	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1048245009062	acyl-activating enzyme (AAE) consensus motif; other site
1048245009063	active site
1048245009064	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1048245009065	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1048245009066	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245009067	S-adenosylmethionine binding site [chemical binding]; other site
1048245009068	Uncharacterized conserved protein [Function unknown]; Region: COG3268
1048245009069	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1048245009070	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245009071	S-adenosylmethionine binding site [chemical binding]; other site
1048245009072	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1048245009073	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1048245009074	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
1048245009075	metal-binding site
1048245009076	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1048245009077	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1048245009078	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1048245009079	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1048245009080	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1048245009081	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1048245009082	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1048245009083	active site
1048245009084	TDP-binding site; other site
1048245009085	acceptor substrate-binding pocket; other site
1048245009086	Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510
1048245009089	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1048245009090	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1048245009091	active site
1048245009092	TDP-binding site; other site
1048245009093	acceptor substrate-binding pocket; other site
1048245009094	Predicted permease; Region: DUF318; pfam03773
1048245009095	formyltetrahydrofolate deformylase; Region: PurU; TIGR00655
1048245009096	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1048245009097	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1048245009098	putative active site [active]
1048245009099	putative substrate binding site [chemical binding]; other site
1048245009100	putative cosubstrate binding site; other site
1048245009101	catalytic site [active]
1048245009102	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1048245009103	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1048245009104	active site
1048245009105	(T/H)XGH motif; other site
1048245009106	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1048245009107	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245009108	S-adenosylmethionine binding site [chemical binding]; other site
1048245009110	pyruvate carboxylase; Reviewed; Region: PRK12999
1048245009111	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1048245009112	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1048245009113	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1048245009114	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1048245009115	active site
1048245009116	catalytic residues [active]
1048245009117	metal binding site [ion binding]; metal-binding site
1048245009118	homodimer binding site [polypeptide binding]; other site
1048245009119	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1048245009120	carboxyltransferase (CT) interaction site; other site
1048245009121	biotinylation site [posttranslational modification]; other site
1048245009125	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
1048245009126	putative active site [active]
1048245009127	redox center [active]
1048245009128	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1048245009129	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
1048245009130	catalytic residues [active]
1048245009131	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1048245009132	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1048245009133	substrate binding pocket [chemical binding]; other site
1048245009134	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
1048245009135	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1048245009136	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1048245009137	active site
1048245009138	catalytic tetrad [active]
1048245009141	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1048245009142	RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
1048245009143	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1048245009144	generic binding surface II; other site
1048245009145	ssDNA binding site; other site
1048245009146	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1048245009147	ATP binding site [chemical binding]; other site
1048245009148	putative Mg++ binding site [ion binding]; other site
1048245009149	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1048245009150	nucleotide binding region [chemical binding]; other site
1048245009151	ATP-binding site [chemical binding]; other site
1048245009153	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1048245009154	DAK2 domain; Region: Dak2; cl03685
1048245009155	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1048245009156	ligand binding site [chemical binding]; other site
1048245009157	active site
1048245009158	UGI interface [polypeptide binding]; other site
1048245009159	catalytic site [active]
1048245009160	thiamine monophosphate kinase; Provisional; Region: PRK05731
1048245009161	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1048245009162	ATP binding site [chemical binding]; other site
1048245009163	dimerization interface [polypeptide binding]; other site
1048245009164	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1048245009165	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1048245009166	Probable transposase; Region: OrfB_IS605; pfam01385
1048245009167	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
1048245009168	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
1048245009169	catalytic residues [active]
1048245009170	catalytic nucleophile [active]
1048245009172	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
1048245009173	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1048245009174	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1048245009175	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1048245009177	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1048245009178	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1048245009179	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1048245009180	Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920
1048245009181	polyphosphate kinase; Provisional; Region: PRK05443
1048245009182	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1048245009183	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1048245009184	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1048245009185	putative domain interface [polypeptide binding]; other site
1048245009186	putative active site [active]
1048245009187	catalytic site [active]
1048245009188	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1048245009189	putative domain interface [polypeptide binding]; other site
1048245009190	putative active site [active]
1048245009191	catalytic site [active]
1048245009192	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1048245009193	active site
1048245009194	Ap6A binding site [chemical binding]; other site
1048245009195	nudix motif; other site
1048245009196	metal binding site [ion binding]; metal-binding site
1048245009197	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1048245009198	catalytic core [active]
1048245009200	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1048245009201	IHF - DNA interface [nucleotide binding]; other site
1048245009202	IHF dimer interface [polypeptide binding]; other site
1048245009204	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1048245009205	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1048245009206	substrate binding site [chemical binding]; other site
1048245009207	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1048245009208	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1048245009209	substrate binding site [chemical binding]; other site
1048245009210	ligand binding site [chemical binding]; other site
1048245009212	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1048245009213	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1048245009214	Bacterial transcriptional regulator; Region: IclR; pfam01614
1048245009215	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245009216	S-adenosylmethionine binding site [chemical binding]; other site
1048245009217	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
1048245009218	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1048245009219	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1048245009220	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1048245009221	active site
1048245009222	HIGH motif; other site
1048245009223	nucleotide binding site [chemical binding]; other site
1048245009224	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1048245009225	active site
1048245009226	KMSKS motif; other site
1048245009227	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1048245009228	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
1048245009229	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1048245009230	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245009231	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1048245009232	putative substrate translocation pore; other site
1048245009233	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
1048245009234	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1048245009235	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1048245009236	ligand binding site [chemical binding]; other site
1048245009237	NAD binding site [chemical binding]; other site
1048245009238	dimerization interface [polypeptide binding]; other site
1048245009239	catalytic site [active]
1048245009240	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1048245009241	putative L-serine binding site [chemical binding]; other site
1048245009245	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1048245009246	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1048245009247	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1048245009248	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
1048245009249	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
1048245009251	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1048245009253	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1048245009254	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1048245009255	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1048245009256	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1048245009257	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1048245009258	putative valine binding site [chemical binding]; other site
1048245009259	dimer interface [polypeptide binding]; other site
1048245009260	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1048245009261	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
1048245009262	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1048245009263	PYR/PP interface [polypeptide binding]; other site
1048245009264	dimer interface [polypeptide binding]; other site
1048245009265	TPP binding site [chemical binding]; other site
1048245009266	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1048245009267	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1048245009268	TPP-binding site [chemical binding]; other site
1048245009269	dimer interface [polypeptide binding]; other site
1048245009271	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1048245009272	Predicted membrane protein [Function unknown]; Region: COG2259
1048245009273	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
1048245009275	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1048245009276	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1048245009277	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1048245009278	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1048245009279	GatB domain; Region: GatB_Yqey; smart00845
1048245009281	6-phosphofructokinase; Provisional; Region: PRK03202
1048245009282	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1048245009283	active site
1048245009284	ADP/pyrophosphate binding site [chemical binding]; other site
1048245009285	dimerization interface [polypeptide binding]; other site
1048245009286	allosteric effector site; other site
1048245009287	fructose-1,6-bisphosphate binding site; other site
1048245009289	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1048245009290	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1048245009292	aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135
1048245009293	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
1048245009294	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1048245009295	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1048245009296	nucleotide binding pocket [chemical binding]; other site
1048245009297	K-X-D-G motif; other site
1048245009298	catalytic site [active]
1048245009299	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1048245009300	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1048245009301	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1048245009302	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1048245009303	Dimer interface [polypeptide binding]; other site
1048245009304	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
1048245009305	PknH-like extracellular domain; Region: PknH_C; pfam14032
1048245009307	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1048245009308	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245009309	PPE family; Region: PPE; pfam00823
1048245009310	Integrase core domain; Region: rve; pfam00665
1048245009311	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1048245009312	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1048245009313	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245009314	Walker A motif; other site
1048245009315	ATP binding site [chemical binding]; other site
1048245009316	Walker B motif; other site
1048245009317	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1048245009318	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245009319	PPE family; Region: PPE; pfam00823
1048245009320	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1048245009321	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1048245009322	Ligand Binding Site [chemical binding]; other site
1048245009323	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1048245009324	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1048245009325	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1048245009326	catalytic residue [active]
1048245009328	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1048245009329	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1048245009330	putative acyl-acceptor binding pocket; other site
1048245009331	Putative hemolysin [General function prediction only]; Region: COG3176
1048245009332	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1048245009333	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1048245009334	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1048245009335	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1048245009336	Ligand binding site [chemical binding]; other site
1048245009337	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1048245009338	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245009339	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1048245009340	S-adenosylmethionine binding site [chemical binding]; other site
1048245009341	Uncharacterized conserved protein [Function unknown]; Region: COG1543
1048245009342	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
1048245009343	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
1048245009344	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1048245009345	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1048245009346	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
1048245009347	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
1048245009348	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1048245009349	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1048245009350	trimer interface [polypeptide binding]; other site
1048245009351	active site
1048245009352	substrate binding site [chemical binding]; other site
1048245009353	CoA binding site [chemical binding]; other site
1048245009354	FOG: WD40-like repeat [Function unknown]; Region: COG1520
1048245009355	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1048245009356	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245009357	S-adenosylmethionine binding site [chemical binding]; other site
1048245009359	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245009360	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1048245009361	substrate binding site [chemical binding]; other site
1048245009362	oxyanion hole (OAH) forming residues; other site
1048245009363	trimer interface [polypeptide binding]; other site
1048245009364	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
1048245009365	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1048245009366	Walker A/P-loop; other site
1048245009367	ATP binding site [chemical binding]; other site
1048245009368	Q-loop/lid; other site
1048245009369	ABC transporter signature motif; other site
1048245009370	Walker B; other site
1048245009371	D-loop; other site
1048245009372	H-loop/switch region; other site
1048245009374	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
1048245009375	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
1048245009376	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1048245009377	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1048245009378	motif II; other site
1048245009379	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1048245009380	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1048245009381	D-pathway; other site
1048245009382	Putative ubiquinol binding site [chemical binding]; other site
1048245009383	Low-spin heme (heme b) binding site [chemical binding]; other site
1048245009384	Putative water exit pathway; other site
1048245009385	Binuclear center (heme o3/CuB) [ion binding]; other site
1048245009386	K-pathway; other site
1048245009387	Putative proton exit pathway; other site
1048245009389	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1048245009390	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1048245009391	siderophore binding site; other site
1048245009392	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1048245009393	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1048245009394	putative NAD(P) binding site [chemical binding]; other site
1048245009395	putative substrate binding site [chemical binding]; other site
1048245009396	catalytic Zn binding site [ion binding]; other site
1048245009397	structural Zn binding site [ion binding]; other site
1048245009398	dimer interface [polypeptide binding]; other site
1048245009400	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
1048245009401	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1048245009402	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1048245009403	dimer interface [polypeptide binding]; other site
1048245009404	putative radical transfer pathway; other site
1048245009405	diiron center [ion binding]; other site
1048245009406	tyrosyl radical; other site
1048245009408	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1048245009409	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1048245009410	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245009411	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245009412	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
1048245009413	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1048245009414	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1048245009415	active site
1048245009416	dimer interface [polypeptide binding]; other site
1048245009417	catalytic residues [active]
1048245009418	effector binding site; other site
1048245009419	R2 peptide binding site; other site
1048245009421	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1048245009422	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1048245009423	catalytic residues [active]
1048245009424	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1048245009425	Predicted flavoprotein [General function prediction only]; Region: COG0431
1048245009427	DNA polymerase IV; Validated; Region: PRK03352
1048245009428	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1048245009429	active site
1048245009430	DNA binding site [nucleotide binding]
1048245009431	short chain dehydrogenase; Provisional; Region: PRK07832
1048245009432	classical (c) SDRs; Region: SDR_c; cd05233
1048245009433	NAD(P) binding site [chemical binding]; other site
1048245009434	active site
1048245009436	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245009437	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245009438	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245009439	Cytochrome P450; Region: p450; cl12078
1048245009441	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1048245009442	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1048245009443	DNA-binding site [nucleotide binding]; DNA binding site
1048245009444	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1048245009445	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1048245009446	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1048245009447	DNA-binding site [nucleotide binding]; DNA binding site
1048245009448	FCD domain; Region: FCD; pfam07729
1048245009450	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245009451	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1048245009452	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245009453	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245009454	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245009455	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245009456	active site
1048245009457	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
1048245009458	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
1048245009459	active site
1048245009460	DNA binding site [nucleotide binding]
1048245009461	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
1048245009462	DNA binding site [nucleotide binding]
1048245009465	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
1048245009466	Carbon starvation protein CstA; Region: CstA; pfam02554
1048245009467	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1048245009469	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
1048245009470	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1048245009471	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245009472	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1048245009473	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
1048245009474	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1048245009475	active site
1048245009476	substrate binding site [chemical binding]; other site
1048245009477	metal binding site [ion binding]; metal-binding site
1048245009480	camphor resistance protein CrcB; Provisional; Region: PRK14216
1048245009481	camphor resistance protein CrcB; Provisional; Region: PRK14228
1048245009482	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
1048245009483	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
1048245009484	Uncharacterized ACR, COG1993; Region: DUF190; pfam02641
1048245009485	putative transposase OrfB; Reviewed; Region: PHA02517
1048245009486	HTH-like domain; Region: HTH_21; pfam13276
1048245009487	Integrase core domain; Region: rve; pfam00665
1048245009488	Integrase core domain; Region: rve_3; pfam13683
1048245009489	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1048245009491	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245009492	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245009493	active site
1048245009494	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1048245009495	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1048245009496	putative hydrophobic ligand binding site [chemical binding]; other site
1048245009497	protein interface [polypeptide binding]; other site
1048245009498	gate; other site
1048245009499	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1048245009500	Sulfatase; Region: Sulfatase; pfam00884
1048245009501	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1048245009502	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1048245009503	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1048245009504	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1048245009505	active site
1048245009506	ATP binding site [chemical binding]; other site
1048245009507	substrate binding site [chemical binding]; other site
1048245009508	activation loop (A-loop); other site
1048245009509	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
1048245009510	AAA ATPase domain; Region: AAA_16; pfam13191
1048245009513	Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970
1048245009515	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1048245009516	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1048245009517	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1048245009518	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1048245009519	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1048245009520	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1048245009521	short chain dehydrogenase; Provisional; Region: PRK07832
1048245009522	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245009523	NAD(P) binding site [chemical binding]; other site
1048245009524	active site
1048245009526	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
1048245009527	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1048245009528	NAD binding site [chemical binding]; other site
1048245009529	catalytic Zn binding site [ion binding]; other site
1048245009530	substrate binding site [chemical binding]; other site
1048245009531	structural Zn binding site [ion binding]; other site
1048245009533	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1048245009534	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1048245009535	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1048245009536	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1048245009537	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
1048245009538	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1048245009539	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245009540	acyl-activating enzyme (AAE) consensus motif; other site
1048245009541	AMP binding site [chemical binding]; other site
1048245009542	active site
1048245009543	CoA binding site [chemical binding]; other site
1048245009546	SPFH domain / Band 7 family; Region: Band_7; pfam01145
1048245009547	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1048245009548	Patatin-like phospholipase; Region: Patatin; pfam01734
1048245009549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
1048245009550	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
1048245009551	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1048245009552	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245009553	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245009554	active site
1048245009555	Predicted transcriptional regulators [Transcription]; Region: COG1733
1048245009556	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1048245009557	dimerization interface [polypeptide binding]; other site
1048245009558	putative DNA binding site [nucleotide binding]; other site
1048245009559	putative Zn2+ binding site [ion binding]; other site
1048245009560	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
1048245009562	PE family; Region: PE; pfam00934
1048245009563	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1048245009564	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1048245009566	putative transposase OrfB; Reviewed; Region: PHA02517
1048245009567	HTH-like domain; Region: HTH_21; pfam13276
1048245009568	Integrase core domain; Region: rve; pfam00665
1048245009569	Integrase core domain; Region: rve_3; pfam13683
1048245009570	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1048245009571	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1048245009572	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1048245009573	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1048245009574	SmpB-tmRNA interface; other site
1048245009575	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1048245009576	FtsX-like permease family; Region: FtsX; pfam02687
1048245009577	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1048245009578	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1048245009579	Walker A/P-loop; other site
1048245009580	ATP binding site [chemical binding]; other site
1048245009581	Q-loop/lid; other site
1048245009582	ABC transporter signature motif; other site
1048245009583	Walker B; other site
1048245009584	D-loop; other site
1048245009585	H-loop/switch region; other site
1048245009588	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1048245009589	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1048245009590	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1048245009591	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1048245009592	RF-1 domain; Region: RF-1; pfam00472
1048245009594	ferredoxin-NADP+ reductase; Region: PLN02852
1048245009595	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1048245009596	FAD binding domain; Region: FAD_binding_4; pfam01565
1048245009597	Transposase [DNA replication, recombination, and repair]; Region: COG5421
1048245009598	Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896
1048245009599	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1048245009600	FeS/SAM binding site; other site
1048245009601	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1048245009602	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
1048245009603	aromatic arch; other site
1048245009604	DCoH dimer interaction site [polypeptide binding]; other site
1048245009605	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1048245009606	DCoH tetramer interaction site [polypeptide binding]; other site
1048245009607	substrate binding site [chemical binding]; other site
1048245009609	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1048245009611	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1048245009612	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1048245009613	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1048245009614	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1048245009615	dimer interface [polypeptide binding]; other site
1048245009616	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1048245009617	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1048245009618	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1048245009619	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1048245009620	Histidine kinase; Region: HisKA_3; pfam07730
1048245009621	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1048245009622	ATP binding site [chemical binding]; other site
1048245009623	Mg2+ binding site [ion binding]; other site
1048245009624	G-X-G motif; other site
1048245009625	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1048245009626	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1048245009627	active site
1048245009628	phosphorylation site [posttranslational modification]
1048245009629	intermolecular recognition site; other site
1048245009630	dimerization interface [polypeptide binding]; other site
1048245009631	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1048245009632	DNA binding residues [nucleotide binding]
1048245009633	dimerization interface [polypeptide binding]; other site
1048245009635	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1048245009636	Ligand Binding Site [chemical binding]; other site
1048245009637	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245009638	PPE family; Region: PPE; pfam00823
1048245009639	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245009640	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245009641	PPE family; Region: PPE; pfam00823
1048245009642	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245009643	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1048245009644	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
1048245009645	active site
1048245009647	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
1048245009648	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1048245009649	FeS/SAM binding site; other site
1048245009650	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245009651	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245009652	active site
1048245009654	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245009655	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245009656	active site
1048245009657	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1048245009658	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1048245009659	NAD(P) binding site [chemical binding]; other site
1048245009660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1048245009661	active site
1048245009662	phosphorylation site [posttranslational modification]
1048245009663	intermolecular recognition site; other site
1048245009664	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245009665	PPE family; Region: PPE; pfam00823
1048245009666	NADH dehydrogenase subunit A; Validated; Region: PRK07928
1048245009667	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1048245009668	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
1048245009669	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1048245009670	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
1048245009671	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1048245009672	NADH dehydrogenase subunit E; Validated; Region: PRK07539
1048245009673	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1048245009674	putative dimer interface [polypeptide binding]; other site
1048245009675	[2Fe-2S] cluster binding site [ion binding]; other site
1048245009676	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
1048245009677	SLBB domain; Region: SLBB; pfam10531
1048245009678	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
1048245009680	NADH dehydrogenase subunit G; Validated; Region: PRK07860
1048245009681	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1048245009682	catalytic loop [active]
1048245009683	iron binding site [ion binding]; other site
1048245009684	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1048245009685	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1048245009686	molybdopterin cofactor binding site; other site
1048245009687	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
1048245009689	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1048245009690	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1048245009692	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1048245009693	4Fe-4S binding domain; Region: Fer4; pfam00037
1048245009694	4Fe-4S binding domain; Region: Fer4; pfam00037
1048245009697	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1048245009698	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1048245009699	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1048245009700	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1048245009701	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1048245009702	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1048245009703	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1048245009704	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1048245009705	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1048245009706	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245009707	PPE family; Region: PPE; pfam00823
1048245009708	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245009709	PPE family; Region: PPE; pfam00823
1048245009710	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245009711	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
1048245009712	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245009713	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1048245009714	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1048245009715	[2Fe-2S] cluster binding site [ion binding]; other site
1048245009716	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885
1048245009717	putative alpha subunit interface [polypeptide binding]; other site
1048245009718	putative active site [active]
1048245009719	putative substrate binding site [chemical binding]; other site
1048245009720	Fe binding site [ion binding]; other site
1048245009721	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1048245009722	Protein of unknown function DUF58; Region: DUF58; pfam01882
1048245009724	MoxR-like ATPases [General function prediction only]; Region: COG0714
1048245009725	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245009726	Walker A motif; other site
1048245009727	ATP binding site [chemical binding]; other site
1048245009728	Walker B motif; other site
1048245009729	arginine finger; other site
1048245009730	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1048245009731	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245009732	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245009733	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
1048245009734	putative active site [active]
1048245009735	putative substrate binding site [chemical binding]; other site
1048245009736	ATP binding site [chemical binding]; other site
1048245009737	Phosphotransferase enzyme family; Region: APH; pfam01636
1048245009739	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1048245009740	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1048245009741	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1048245009742	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245009743	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1048245009745	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245009746	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245009747	short chain dehydrogenase; Validated; Region: PRK08264
1048245009748	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245009749	NAD(P) binding site [chemical binding]; other site
1048245009750	active site
1048245009751	amidase; Provisional; Region: PRK06170
1048245009752	Amidase; Region: Amidase; pfam01425
1048245009754	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245009755	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245009756	TAP-like protein; Region: Abhydrolase_4; pfam08386
1048245009757	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1048245009758	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
1048245009759	AAA domain; Region: AAA_14; pfam13173
1048245009761	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1048245009762	putative active site [active]
1048245009763	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1048245009764	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683
1048245009765	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1048245009766	non-specific DNA binding site [nucleotide binding]; other site
1048245009767	salt bridge; other site
1048245009768	sequence-specific DNA binding site [nucleotide binding]; other site
1048245009769	RES domain; Region: RES; cl02411
1048245009770	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1048245009771	Transposase; Region: HTH_Tnp_1; cl17663
1048245009772	putative transposase OrfB; Reviewed; Region: PHA02517
1048245009773	HTH-like domain; Region: HTH_21; pfam13276
1048245009774	Integrase core domain; Region: rve; pfam00665
1048245009775	Integrase core domain; Region: rve_3; pfam13683
1048245009776	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1048245009777	Helix-turn-helix domain; Region: HTH_38; pfam13936
1048245009778	Integrase core domain; Region: rve; pfam00665
1048245009779	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
1048245009780	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1048245009781	hypothetical protein; Validated; Region: PRK00068
1048245009782	Uncharacterized conserved protein [Function unknown]; Region: COG1615
1048245009783	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
1048245009784	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1048245009785	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
1048245009786	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1048245009787	Uncharacterized conserved protein [Function unknown]; Region: COG5282
1048245009788	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
1048245009789	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
1048245009790	ABC1 family; Region: ABC1; pfam03109
1048245009791	Phosphotransferase enzyme family; Region: APH; pfam01636
1048245009792	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1048245009793	active site
1048245009794	ATP binding site [chemical binding]; other site
1048245009796	Transcription factor WhiB; Region: Whib; pfam02467
1048245009797	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1048245009798	Part of AAA domain; Region: AAA_19; pfam13245
1048245009799	Family description; Region: UvrD_C_2; pfam13538
1048245009800	HRDC domain; Region: HRDC; pfam00570
1048245009802	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1048245009803	catalytic residues [active]
1048245009804	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
1048245009805	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
1048245009806	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1048245009807	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1048245009808	putative NADH binding site [chemical binding]; other site
1048245009809	putative active site [active]
1048245009810	nudix motif; other site
1048245009811	putative metal binding site [ion binding]; other site
1048245009813	Ion channel; Region: Ion_trans_2; pfam07885
1048245009814	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1048245009815	TrkA-N domain; Region: TrkA_N; pfam02254
1048245009817	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1048245009818	Part of AAA domain; Region: AAA_19; pfam13245
1048245009819	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
1048245009821	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1048245009822	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1048245009823	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
1048245009824	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1048245009825	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1048245009826	catalytic site [active]
1048245009828	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1048245009829	active site
1048245009830	DNA binding site [nucleotide binding]
1048245009831	TIGR02569 family protein; Region: TIGR02569_actnb
1048245009832	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
1048245009833	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1048245009834	ATP binding site [chemical binding]; other site
1048245009835	substrate interface [chemical binding]; other site
1048245009836	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1048245009837	active site residue [active]
1048245009838	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
1048245009840	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245009841	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245009842	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
1048245009843	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794
1048245009844	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1048245009845	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1048245009846	ATP binding site [chemical binding]; other site
1048245009847	Mg++ binding site [ion binding]; other site
1048245009848	motif III; other site
1048245009849	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1048245009850	nucleotide binding region [chemical binding]; other site
1048245009851	ATP-binding site [chemical binding]; other site
1048245009854	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1048245009855	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1048245009856	P-loop; other site
1048245009857	Magnesium ion binding site [ion binding]; other site
1048245009858	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1048245009859	Magnesium ion binding site [ion binding]; other site
1048245009860	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1048245009861	catalytic core [active]
1048245009862	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1048245009863	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1048245009864	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1048245009865	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1048245009866	Transcription factor WhiB; Region: Whib; pfam02467
1048245009867	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
1048245009868	PAS domain S-box; Region: sensory_box; TIGR00229
1048245009869	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1048245009870	Histidine kinase; Region: HisKA_2; pfam07568
1048245009871	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1048245009872	ATP binding site [chemical binding]; other site
1048245009873	Mg2+ binding site [ion binding]; other site
1048245009874	G-X-G motif; other site
1048245009875	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1048245009876	carboxyltransferase (CT) interaction site; other site
1048245009877	biotinylation site [posttranslational modification]; other site
1048245009878	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
1048245009879	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
1048245009880	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1048245009881	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1048245009882	DNA binding residues [nucleotide binding]
1048245009884	short chain dehydrogenase; Provisional; Region: PRK08278
1048245009885	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
1048245009886	NAD(P) binding site [chemical binding]; other site
1048245009887	homodimer interface [polypeptide binding]; other site
1048245009888	active site
1048245009890	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1048245009891	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1048245009892	Coenzyme A binding pocket [chemical binding]; other site
1048245009893	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
1048245009894	Phosphotransferase enzyme family; Region: APH; pfam01636
1048245009895	putative active site [active]
1048245009896	putative substrate binding site [chemical binding]; other site
1048245009897	ATP binding site [chemical binding]; other site
1048245009898	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1048245009899	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1048245009900	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1048245009901	hinge; other site
1048245009902	active site
1048245009904	Predicted GTPases [General function prediction only]; Region: COG1162
1048245009905	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1048245009906	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1048245009907	GTP/Mg2+ binding site [chemical binding]; other site
1048245009908	G4 box; other site
1048245009909	G5 box; other site
1048245009910	G1 box; other site
1048245009911	Switch I region; other site
1048245009912	G2 box; other site
1048245009913	G3 box; other site
1048245009914	Switch II region; other site
1048245009916	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1048245009917	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1048245009918	putative di-iron ligands [ion binding]; other site
1048245009919	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
1048245009920	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1048245009921	FAD binding pocket [chemical binding]; other site
1048245009922	FAD binding motif [chemical binding]; other site
1048245009923	phosphate binding motif [ion binding]; other site
1048245009924	beta-alpha-beta structure motif; other site
1048245009925	NAD binding pocket [chemical binding]; other site
1048245009926	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1048245009927	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1048245009928	catalytic loop [active]
1048245009929	iron binding site [ion binding]; other site
1048245009930	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1048245009931	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1048245009932	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1048245009933	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1048245009934	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1048245009935	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
1048245009936	TrkA-C domain; Region: TrkA_C; pfam02080
1048245009937	Phospholipid methyltransferase; Region: PEMT; cl17370
1048245009939	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1048245009940	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1048245009941	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1048245009944	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1048245009945	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1048245009946	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1048245009947	30S subunit binding site; other site
1048245009948	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1048245009949	active site
1048245009950	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
1048245009953	lipoprotein LpqB; Provisional; Region: PRK13616
1048245009954	Sporulation and spore germination; Region: Germane; pfam10646
1048245009956	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1048245009957	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1048245009958	dimerization interface [polypeptide binding]; other site
1048245009959	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1048245009960	dimer interface [polypeptide binding]; other site
1048245009961	phosphorylation site [posttranslational modification]
1048245009962	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1048245009963	ATP binding site [chemical binding]; other site
1048245009964	Mg2+ binding site [ion binding]; other site
1048245009965	G-X-G motif; other site
1048245009966	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1048245009967	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1048245009968	active site
1048245009969	phosphorylation site [posttranslational modification]
1048245009970	intermolecular recognition site; other site
1048245009971	dimerization interface [polypeptide binding]; other site
1048245009972	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1048245009973	DNA binding site [nucleotide binding]
1048245009974	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
1048245009975	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1048245009976	TMP-binding site; other site
1048245009977	ATP-binding site [chemical binding]; other site
1048245009978	Adenosylhomocysteinase; Provisional; Region: PTZ00075
1048245009979	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1048245009980	homotetramer interface [polypeptide binding]; other site
1048245009981	ligand binding site [chemical binding]; other site
1048245009982	catalytic site [active]
1048245009983	NAD binding site [chemical binding]; other site
1048245009985	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245009986	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1048245009987	Rubredoxin [Energy production and conversion]; Region: COG1773
1048245009988	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1048245009989	iron binding site [ion binding]; other site
1048245009991	Rubredoxin [Energy production and conversion]; Region: COG1773
1048245009992	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1048245009993	iron binding site [ion binding]; other site
1048245009995	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
1048245009996	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1048245009997	Di-iron ligands [ion binding]; other site
1048245009998	amino acid transporter; Region: 2A0306; TIGR00909
1048245009999	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1048245010000	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1048245010001	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1048245010002	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1048245010003	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1048245010004	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1048245010005	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
1048245010006	active site
1048245010007	substrate binding site [chemical binding]; other site
1048245010008	metal binding site [ion binding]; metal-binding site
1048245010009	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
1048245010010	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
1048245010011	Transcription factor WhiB; Region: Whib; pfam02467
1048245010012	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
1048245010013	LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186
1048245010014	phosphate binding site [ion binding]; other site
1048245010015	dimer interface [polypeptide binding]; other site
1048245010016	substrate binding site [chemical binding]; other site
1048245010017	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
1048245010018	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
1048245010019	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
1048245010020	putative FMN binding site [chemical binding]; other site
1048245010021	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1048245010022	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1048245010024	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1048245010025	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1048245010026	active site
1048245010027	Substrate binding site; other site
1048245010028	Mg++ binding site; other site
1048245010029	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1048245010030	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1048245010031	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1048245010032	Probable Catalytic site; other site
1048245010033	metal-binding site
1048245010034	dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214
1048245010035	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1048245010036	NADP binding site [chemical binding]; other site
1048245010037	active site
1048245010038	putative substrate binding site [chemical binding]; other site
1048245010039	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1048245010040	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1048245010042	TIGR03089 family protein; Region: TIGR03089
1048245010043	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
1048245010044	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1048245010045	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1048245010046	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1048245010047	active site
1048245010048	motif I; other site
1048245010049	motif II; other site
1048245010051	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245010052	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245010053	active site
1048245010054	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1048245010055	Probable transposase; Region: OrfB_IS605; pfam01385
1048245010056	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
1048245010057	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1048245010058	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1048245010059	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1048245010060	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1048245010061	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1048245010062	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288
1048245010063	active site clefts [active]
1048245010064	zinc binding site [ion binding]; other site
1048245010065	dimer interface [polypeptide binding]; other site
1048245010067	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245010068	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1048245010069	FAD binding site [chemical binding]; other site
1048245010070	homotetramer interface [polypeptide binding]; other site
1048245010071	substrate binding pocket [chemical binding]; other site
1048245010072	catalytic base [active]
1048245010075	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1048245010076	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026
1048245010077	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1048245010078	Predicted membrane protein [Function unknown]; Region: COG2246
1048245010079	GtrA-like protein; Region: GtrA; pfam04138
1048245010081	Bacterial PH domain; Region: DUF304; pfam03703
1048245010082	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1048245010083	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1048245010084	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1048245010085	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1048245010086	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1048245010087	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1048245010088	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
1048245010089	Maf-like protein; Region: Maf; pfam02545
1048245010090	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1048245010091	active site
1048245010092	dimer interface [polypeptide binding]; other site
1048245010093	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1048245010094	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1048245010095	active site residue [active]
1048245010096	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1048245010097	active site residue [active]
1048245010099	Fe-S metabolism associated domain; Region: SufE; pfam02657
1048245010100	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1048245010101	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1048245010102	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1048245010103	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1048245010104	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1048245010105	carboxyltransferase (CT) interaction site; other site
1048245010106	biotinylation site [posttranslational modification]; other site
1048245010109	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
1048245010110	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1048245010111	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1048245010112	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1048245010113	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1048245010114	L-lysine aminotransferase; Provisional; Region: PRK08297
1048245010115	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1048245010116	inhibitor-cofactor binding pocket; inhibition site
1048245010117	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245010118	catalytic residue [active]
1048245010119	putative DNA binding site [nucleotide binding]; other site
1048245010120	dimerization interface [polypeptide binding]; other site
1048245010121	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1048245010122	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1048245010123	putative Zn2+ binding site [ion binding]; other site
1048245010124	AsnC family; Region: AsnC_trans_reg; pfam01037
1048245010125	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
1048245010126	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
1048245010127	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1048245010128	tetrameric interface [polypeptide binding]; other site
1048245010129	NAD binding site [chemical binding]; other site
1048245010130	catalytic residues [active]
1048245010132	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
1048245010133	AAA domain; Region: AAA_14; pfam13173
1048245010134	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245010135	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245010136	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1048245010137	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
1048245010138	ATP binding site [chemical binding]; other site
1048245010139	putative Mg++ binding site [ion binding]; other site
1048245010140	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1048245010141	nucleotide binding region [chemical binding]; other site
1048245010142	ATP-binding site [chemical binding]; other site
1048245010143	DEAD/H associated; Region: DEAD_assoc; pfam08494
1048245010145	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1048245010146	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
1048245010147	putative DNA binding site [nucleotide binding]; other site
1048245010148	catalytic residue [active]
1048245010149	putative H2TH interface [polypeptide binding]; other site
1048245010150	putative catalytic residues [active]
1048245010151	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1048245010152	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
1048245010153	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1048245010154	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1048245010155	Sulfatase; Region: Sulfatase; pfam00884
1048245010158	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
1048245010159	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1048245010160	probable active site [active]
1048245010161	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1048245010162	PhoU domain; Region: PhoU; pfam01895
1048245010163	PhoU domain; Region: PhoU; pfam01895
1048245010164	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1048245010166	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
1048245010167	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1048245010168	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1048245010169	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1048245010170	putative active site pocket [active]
1048245010171	dimerization interface [polypeptide binding]; other site
1048245010172	putative catalytic residue [active]
1048245010173	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1048245010174	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
1048245010175	metal binding site [ion binding]; metal-binding site
1048245010176	putative dimer interface [polypeptide binding]; other site
1048245010178	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1048245010179	amidohydrolase; Region: amidohydrolases; TIGR01891
1048245010180	metal binding site [ion binding]; metal-binding site
1048245010181	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1048245010182	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1048245010183	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1048245010184	active site
1048245010185	substrate binding site [chemical binding]; other site
1048245010186	metal binding site [ion binding]; metal-binding site
1048245010188	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1048245010189	active site
1048245010190	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1048245010192	Integrase core domain; Region: rve; pfam00665
1048245010193	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1048245010194	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1048245010195	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245010196	Walker A motif; other site
1048245010197	ATP binding site [chemical binding]; other site
1048245010198	Walker B motif; other site
1048245010199	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1048245010200	adenosine deaminase; Provisional; Region: PRK09358
1048245010201	active site
1048245010202	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
1048245010203	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1048245010204	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1048245010205	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1048245010207	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1048245010208	active site
1048245010209	catalytic motif [active]
1048245010210	Zn binding site [ion binding]; other site
1048245010212	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
1048245010213	putative Iron-sulfur protein interface [polypeptide binding]; other site
1048245010214	putative proximal heme binding site [chemical binding]; other site
1048245010215	putative SdhD-like interface [polypeptide binding]; other site
1048245010216	putative distal heme binding site [chemical binding]; other site
1048245010217	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
1048245010218	putative Iron-sulfur protein interface [polypeptide binding]; other site
1048245010219	putative proximal heme binding site [chemical binding]; other site
1048245010220	putative SdhC-like subunit interface [polypeptide binding]; other site
1048245010221	putative distal heme binding site [chemical binding]; other site
1048245010222	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
1048245010223	L-aspartate oxidase; Provisional; Region: PRK06175
1048245010224	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1048245010226	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1048245010227	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1048245010229	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1048245010230	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1048245010231	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245010232	S-adenosylmethionine binding site [chemical binding]; other site
1048245010233	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1048245010234	MoaE interaction surface [polypeptide binding]; other site
1048245010235	MoeB interaction surface [polypeptide binding]; other site
1048245010236	thiocarboxylated glycine; other site
1048245010237	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1048245010238	MoaE homodimer interface [polypeptide binding]; other site
1048245010239	MoaD interaction [polypeptide binding]; other site
1048245010240	active site residues [active]
1048245010241	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1048245010242	trimer interface [polypeptide binding]; other site
1048245010243	dimer interface [polypeptide binding]; other site
1048245010244	putative active site [active]
1048245010245	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942
1048245010246	substrate binding site [chemical binding]; other site
1048245010247	Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896
1048245010248	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1048245010249	FeS/SAM binding site; other site
1048245010250	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1048245010251	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
1048245010252	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
1048245010253	DNA binding site [nucleotide binding]
1048245010254	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1048245010255	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1048245010256	phosphopeptide binding site; other site
1048245010257	HTH-like domain; Region: HTH_21; pfam13276
1048245010258	Integrase core domain; Region: rve; pfam00665
1048245010260	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
1048245010261	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1048245010262	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1048245010263	DNA binding residues [nucleotide binding]
1048245010264	SnoaL-like domain; Region: SnoaL_2; pfam12680
1048245010265	hypothetical protein; Provisional; Region: PRK06541
1048245010266	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1048245010267	inhibitor-cofactor binding pocket; inhibition site
1048245010268	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245010269	catalytic residue [active]
1048245010270	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1048245010271	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1048245010272	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1048245010273	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245010276	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1048245010277	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1048245010278	active site
1048245010279	dimer interface [polypeptide binding]; other site
1048245010280	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1048245010281	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
1048245010282	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1048245010283	DNA binding residues [nucleotide binding]
1048245010284	dimer interface [polypeptide binding]; other site
1048245010285	metal binding site [ion binding]; metal-binding site
1048245010286	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
1048245010287	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1048245010288	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1048245010289	active site
1048245010290	HIGH motif; other site
1048245010291	dimer interface [polypeptide binding]; other site
1048245010292	KMSKS motif; other site
1048245010294	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245010295	isocitrate dehydrogenase; Validated; Region: PRK08299
1048245010297	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
1048245010298	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1048245010299	homodimer interface [polypeptide binding]; other site
1048245010300	substrate-cofactor binding pocket; other site
1048245010301	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245010302	catalytic residue [active]
1048245010304	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1048245010305	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
1048245010306	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1048245010307	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245010308	S-adenosylmethionine binding site [chemical binding]; other site
1048245010309	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010310	PPE family; Region: PPE; pfam00823
1048245010311	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010312	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010313	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010314	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010315	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010316	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010317	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010318	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010319	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010320	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010321	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010322	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010323	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010324	PE family; Region: PE; pfam00934
1048245010325	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
1048245010326	PPE family; Region: PPE; pfam00823
1048245010327	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010328	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010329	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010330	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010331	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010332	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010333	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010334	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010335	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010336	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010337	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010338	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010340	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1048245010341	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010342	PPE family; Region: PPE; pfam00823
1048245010343	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010344	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010345	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010346	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010347	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010348	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010349	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010350	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010351	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010352	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010353	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010354	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010355	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010356	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010357	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010358	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010359	Berberine and berberine like; Region: BBE; pfam08031
1048245010360	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1048245010361	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1048245010362	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
1048245010363	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
1048245010364	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1048245010365	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1048245010366	homodimer interface [polypeptide binding]; other site
1048245010367	NADP binding site [chemical binding]; other site
1048245010368	substrate binding site [chemical binding]; other site
1048245010369	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1048245010370	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
1048245010371	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1048245010372	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
1048245010373	active site
1048245010374	FMN binding site [chemical binding]; other site
1048245010375	substrate binding site [chemical binding]; other site
1048245010376	putative catalytic residue [active]
1048245010377	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1048245010378	phosphate binding site [ion binding]; other site
1048245010379	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1048245010380	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1048245010381	phosphopeptide binding site; other site
1048245010382	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1048245010383	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1048245010384	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1048245010385	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1048245010386	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1048245010387	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
1048245010388	G1 box; other site
1048245010389	GTP/Mg2+ binding site [chemical binding]; other site
1048245010390	G2 box; other site
1048245010391	Switch I region; other site
1048245010392	G3 box; other site
1048245010393	Switch II region; other site
1048245010394	G4 box; other site
1048245010395	G5 box; other site
1048245010397	Protein of unknown function (DUF742); Region: DUF742; pfam05331
1048245010398	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
1048245010399	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1048245010400	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1048245010401	ATP binding site [chemical binding]; other site
1048245010402	Mg2+ binding site [ion binding]; other site
1048245010403	G-X-G motif; other site
1048245010405	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1048245010406	PE family; Region: PE; pfam00934
1048245010407	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
1048245010408	FMN binding site [chemical binding]; other site
1048245010409	dimer interface [polypeptide binding]; other site
1048245010410	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1048245010412	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1048245010413	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1048245010414	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1048245010415	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
1048245010416	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1048245010417	active site
1048245010418	motif I; other site
1048245010419	motif II; other site
1048245010420	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245010421	substrate binding site [chemical binding]; other site
1048245010422	oxyanion hole (OAH) forming residues; other site
1048245010423	trimer interface [polypeptide binding]; other site
1048245010424	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
1048245010425	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1048245010426	Amidase; Region: Amidase; pfam01425
1048245010427	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1048245010428	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1048245010429	motif II; other site
1048245010430	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
1048245010431	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
1048245010432	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
1048245010433	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
1048245010434	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1048245010435	TPP-binding site [chemical binding]; other site
1048245010436	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1048245010437	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1048245010438	PYR/PP interface [polypeptide binding]; other site
1048245010439	dimer interface [polypeptide binding]; other site
1048245010440	TPP binding site [chemical binding]; other site
1048245010441	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1048245010442	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1048245010443	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1048245010444	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1048245010445	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1048245010446	substrate binding pocket [chemical binding]; other site
1048245010447	chain length determination region; other site
1048245010448	substrate-Mg2+ binding site; other site
1048245010449	catalytic residues [active]
1048245010450	aspartate-rich region 1; other site
1048245010451	active site lid residues [active]
1048245010452	aspartate-rich region 2; other site
1048245010454	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1048245010455	MULE transposase domain; Region: MULE; pfam10551
1048245010456	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
1048245010457	putative active site [active]
1048245010458	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1048245010459	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1048245010460	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1048245010461	enoyl-CoA hydratase; Region: PLN02864
1048245010462	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1048245010463	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
1048245010464	dimer interaction site [polypeptide binding]; other site
1048245010465	substrate-binding tunnel; other site
1048245010466	active site
1048245010467	catalytic site [active]
1048245010468	substrate binding site [chemical binding]; other site
1048245010469	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1048245010471	short chain dehydrogenase; Provisional; Region: PRK07201
1048245010472	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
1048245010473	putative NAD(P) binding site [chemical binding]; other site
1048245010474	active site
1048245010475	putative substrate binding site [chemical binding]; other site
1048245010476	classical (c) SDRs; Region: SDR_c; cd05233
1048245010477	NAD(P) binding site [chemical binding]; other site
1048245010478	active site
1048245010479	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1048245010480	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1048245010481	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245010482	S-adenosylmethionine binding site [chemical binding]; other site
1048245010483	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
1048245010484	active site
1048245010485	DNA Polymerase Y-family; Region: PolY_like; cd03468
1048245010486	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1048245010487	DNA binding site [nucleotide binding]
1048245010488	GMP synthase; Reviewed; Region: guaA; PRK00074
1048245010489	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1048245010490	AMP/PPi binding site [chemical binding]; other site
1048245010491	candidate oxyanion hole; other site
1048245010492	catalytic triad [active]
1048245010493	potential glutamine specificity residues [chemical binding]; other site
1048245010494	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1048245010495	ATP Binding subdomain [chemical binding]; other site
1048245010496	Ligand Binding sites [chemical binding]; other site
1048245010497	Dimerization subdomain; other site
1048245010499	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1048245010500	active site lid residues [active]
1048245010501	substrate binding pocket [chemical binding]; other site
1048245010502	catalytic residues [active]
1048245010503	substrate-Mg2+ binding site; other site
1048245010504	aspartate-rich region 1; other site
1048245010505	aspartate-rich region 2; other site
1048245010509	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1048245010510	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1048245010511	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1048245010512	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1048245010513	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
1048245010514	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1048245010515	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1048245010516	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1048245010517	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1048245010518	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1048245010519	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1048245010520	catalytic residue [active]
1048245010521	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1048245010522	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1048245010523	hypothetical protein; Provisional; Region: PRK07579
1048245010524	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
1048245010525	active site
1048245010526	cosubstrate binding site; other site
1048245010527	substrate binding site [chemical binding]; other site
1048245010528	catalytic site [active]
1048245010529	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245010530	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245010531	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1048245010532	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1048245010533	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1048245010534	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
1048245010535	putative active site [active]
1048245010536	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1048245010537	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1048245010538	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1048245010540	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
1048245010541	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1048245010542	phosphate binding site [ion binding]; other site
1048245010543	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1048245010544	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1048245010545	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1048245010546	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1048245010547	active site
1048245010549	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
1048245010550	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1048245010551	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1048245010552	DNA binding residues [nucleotide binding]
1048245010553	Transcription factor WhiB; Region: Whib; pfam02467
1048245010554	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1048245010555	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1048245010556	ring oligomerisation interface [polypeptide binding]; other site
1048245010557	ATP/Mg binding site [chemical binding]; other site
1048245010558	stacking interactions; other site
1048245010559	hinge regions; other site
1048245010562	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1048245010563	oligomerisation interface [polypeptide binding]; other site
1048245010564	mobile loop; other site
1048245010565	roof hairpin; other site
1048245010567	UGMP family protein; Validated; Region: PRK09604
1048245010569	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1048245010570	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1048245010571	Coenzyme A binding pocket [chemical binding]; other site
1048245010572	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
1048245010573	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
1048245010575	alanine racemase; Reviewed; Region: alr; PRK00053
1048245010576	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1048245010577	active site
1048245010578	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1048245010579	dimer interface [polypeptide binding]; other site
1048245010580	substrate binding site [chemical binding]; other site
1048245010581	catalytic residues [active]
1048245010582	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245010583	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1048245010584	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245010585	catalytic residue [active]
1048245010586	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1048245010587	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1048245010588	putative substrate binding site [chemical binding]; other site
1048245010589	putative ATP binding site [chemical binding]; other site
1048245010592	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1048245010593	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1048245010594	glutaminase active site [active]
1048245010595	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1048245010596	dimer interface [polypeptide binding]; other site
1048245010597	active site
1048245010598	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1048245010599	dimer interface [polypeptide binding]; other site
1048245010600	active site
1048245010601	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
1048245010602	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
1048245010603	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1048245010604	active site
1048245010605	substrate binding site [chemical binding]; other site
1048245010606	metal binding site [ion binding]; metal-binding site
1048245010608	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1048245010610	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1048245010611	23S rRNA interface [nucleotide binding]; other site
1048245010612	L3 interface [polypeptide binding]; other site
1048245010613	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1048245010614	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1048245010615	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
1048245010616	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1048245010617	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1048245010618	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1048245010619	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1048245010620	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1048245010624	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1048245010626	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1048245010627	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1048245010628	active site
1048245010629	catalytic residues [active]
1048245010633	Protein of unknown function (DUF690); Region: DUF690; pfam05108
1048245010635	Cutinase; Region: Cutinase; pfam01083
1048245010636	Cutinase; Region: Cutinase; pfam01083
1048245010637	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1048245010639	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1048245010640	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1048245010641	active site
1048245010642	dimerization interface 3.5A [polypeptide binding]; other site
1048245010643	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1048245010644	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1048245010645	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1048245010646	alphaNTD - beta interaction site [polypeptide binding]; other site
1048245010647	alphaNTD homodimer interface [polypeptide binding]; other site
1048245010648	alphaNTD - beta' interaction site [polypeptide binding]; other site
1048245010649	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1048245010651	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1048245010652	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1048245010653	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1048245010654	RNA binding surface [nucleotide binding]; other site
1048245010657	30S ribosomal protein S11; Validated; Region: PRK05309
1048245010659	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1048245010660	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1048245010662	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1048245010664	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1048245010665	rRNA binding site [nucleotide binding]; other site
1048245010666	predicted 30S ribosome binding site; other site
1048245010667	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1048245010668	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1048245010669	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1048245010670	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1048245010671	NAD binding site [chemical binding]; other site
1048245010672	substrate binding site [chemical binding]; other site
1048245010673	homodimer interface [polypeptide binding]; other site
1048245010674	active site
1048245010675	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1048245010676	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245010677	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245010678	active site
1048245010679	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1048245010680	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245010681	NAD(P) binding site [chemical binding]; other site
1048245010682	active site
1048245010683	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
1048245010684	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
1048245010685	active site
1048245010686	catalytic residues [active]
1048245010687	metal binding site [ion binding]; metal-binding site
1048245010688	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1048245010689	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1048245010690	PYR/PP interface [polypeptide binding]; other site
1048245010691	dimer interface [polypeptide binding]; other site
1048245010692	TPP binding site [chemical binding]; other site
1048245010693	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1048245010694	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1048245010695	TPP-binding site [chemical binding]; other site
1048245010697	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1048245010698	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
1048245010699	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245010700	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1048245010701	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245010702	metabolite-proton symporter; Region: 2A0106; TIGR00883
1048245010703	putative substrate translocation pore; other site
1048245010706	PE family; Region: PE; pfam00934
1048245010707	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010708	PPE family; Region: PPE; pfam00823
1048245010709	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245010710	patatin-related protein; Region: TIGR03607
1048245010711	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1048245010712	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1048245010713	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
1048245010714	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
1048245010715	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
1048245010716	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
1048245010717	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1048245010718	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1048245010719	short chain dehydrogenase; Provisional; Region: PRK05875
1048245010720	classical (c) SDRs; Region: SDR_c; cd05233
1048245010721	NAD(P) binding site [chemical binding]; other site
1048245010722	active site
1048245010724	Predicted membrane protein [Function unknown]; Region: COG2259
1048245010725	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1048245010726	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1048245010727	Predicted transcriptional regulators [Transcription]; Region: COG1695
1048245010728	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1048245010729	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
1048245010730	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1048245010731	active site
1048245010732	homotetramer interface [polypeptide binding]; other site
1048245010734	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245010735	mce related protein; Region: MCE; pfam02470
1048245010736	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245010737	mce related protein; Region: MCE; pfam02470
1048245010739	mce related protein; Region: MCE; pfam02470
1048245010740	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245010741	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1048245010742	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245010743	mce related protein; Region: MCE; pfam02470
1048245010744	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245010745	mce related protein; Region: MCE; pfam02470
1048245010746	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1048245010747	mce related protein; Region: MCE; pfam02470
1048245010748	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1048245010749	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1048245010750	Permease; Region: Permease; pfam02405
1048245010751	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1048245010752	Permease; Region: Permease; pfam02405
1048245010753	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
1048245010754	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245010755	NAD(P) binding site [chemical binding]; other site
1048245010756	active site
1048245010758	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
1048245010759	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1048245010760	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245010761	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
1048245010762	FAD binding site [chemical binding]; other site
1048245010763	substrate binding site [chemical binding]; other site
1048245010764	catalytic base [active]
1048245010765	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245010766	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1048245010767	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245010768	active site
1048245010771	PE family; Region: PE; pfam00934
1048245010772	hypothetical protein; Validated; Region: PRK07586
1048245010773	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1048245010774	PYR/PP interface [polypeptide binding]; other site
1048245010775	dimer interface [polypeptide binding]; other site
1048245010776	TPP binding site [chemical binding]; other site
1048245010777	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
1048245010778	TPP-binding site [chemical binding]; other site
1048245010779	dimer interface [polypeptide binding]; other site
1048245010780	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1048245010781	PE family; Region: PE; pfam00934
1048245010782	acyl-CoA synthetase; Validated; Region: PRK07798
1048245010783	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245010784	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
1048245010785	acyl-activating enzyme (AAE) consensus motif; other site
1048245010786	acyl-activating enzyme (AAE) consensus motif; other site
1048245010787	putative AMP binding site [chemical binding]; other site
1048245010788	putative active site [active]
1048245010789	putative CoA binding site [chemical binding]; other site
1048245010791	enoyl-CoA hydratase; Provisional; Region: PRK07799
1048245010792	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245010793	substrate binding site [chemical binding]; other site
1048245010794	oxyanion hole (OAH) forming residues; other site
1048245010795	trimer interface [polypeptide binding]; other site
1048245010796	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1048245010797	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245010798	Cytochrome P450; Region: p450; cl12078
1048245010800	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
1048245010801	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1048245010802	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
1048245010803	DUF35 OB-fold domain; Region: DUF35; pfam01796
1048245010804	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
1048245010805	DUF35 OB-fold domain; Region: DUF35; pfam01796
1048245010806	lipid-transfer protein; Provisional; Region: PRK07937
1048245010807	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1048245010808	active site
1048245010810	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
1048245010811	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1048245010812	active site
1048245010813	NHL repeat; Region: NHL; pfam01436
1048245010814	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1048245010815	NHL repeat; Region: NHL; pfam01436
1048245010816	NHL repeat; Region: NHL; pfam01436
1048245010817	NHL repeat; Region: NHL; pfam01436
1048245010818	NHL repeat; Region: NHL; pfam01436
1048245010820	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1048245010821	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1048245010822	trimer interface [polypeptide binding]; other site
1048245010823	putative metal binding site [ion binding]; other site
1048245010824	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1048245010825	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
1048245010826	O-methyltransferase; Region: Methyltransf_2; pfam00891
1048245010827	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
1048245010828	short chain dehydrogenase; Provisional; Region: PRK07890
1048245010829	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245010830	NAD(P) binding site [chemical binding]; other site
1048245010831	active site
1048245010832	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010833	PPE family; Region: PPE; pfam00823
1048245010834	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1048245010835	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010836	PPE family; Region: PPE; pfam00823
1048245010837	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010838	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1048245010839	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
1048245010840	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
1048245010841	active site
1048245010842	catalytic residues [active]
1048245010843	metal binding site [ion binding]; metal-binding site
1048245010844	DmpG-like communication domain; Region: DmpG_comm; pfam07836
1048245010845	acetaldehyde dehydrogenase; Validated; Region: PRK08300
1048245010846	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1048245010847	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
1048245010848	2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971
1048245010849	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
1048245010850	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1048245010851	enoyl-CoA hydratase; Region: PLN02864
1048245010852	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1048245010853	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
1048245010854	dimer interaction site [polypeptide binding]; other site
1048245010855	substrate-binding tunnel; other site
1048245010856	active site
1048245010857	catalytic site [active]
1048245010858	substrate binding site [chemical binding]; other site
1048245010859	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010860	PPE family; Region: PPE; pfam00823
1048245010861	PE-PPE domain; Region: PE-PPE; pfam08237
1048245010862	lipid-transfer protein; Provisional; Region: PRK07855
1048245010863	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1048245010864	active site
1048245010865	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
1048245010866	putative active site [active]
1048245010867	putative catalytic site [active]
1048245010869	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1048245010870	active site
1048245010871	catalytic site [active]
1048245010872	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
1048245010873	DUF35 OB-fold domain; Region: DUF35; pfam01796
1048245010874	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245010875	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245010876	active site
1048245010877	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245010878	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1048245010879	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245010880	active site
1048245010881	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245010882	Cytochrome P450; Region: p450; cl12078
1048245010883	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
1048245010884	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1048245010885	dimer interface [polypeptide binding]; other site
1048245010886	active site
1048245010888	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1048245010889	short chain dehydrogenase; Provisional; Region: PRK07791
1048245010890	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
1048245010891	homodimer interface [polypeptide binding]; other site
1048245010892	NAD binding site [chemical binding]; other site
1048245010893	active site
1048245010895	short chain dehydrogenase; Provisional; Region: PRK07856
1048245010896	classical (c) SDRs; Region: SDR_c; cd05233
1048245010897	NAD(P) binding site [chemical binding]; other site
1048245010898	active site
1048245010900	enoyl-CoA hydratase; Provisional; Region: PRK06495
1048245010901	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245010902	substrate binding site [chemical binding]; other site
1048245010903	oxyanion hole (OAH) forming residues; other site
1048245010904	trimer interface [polypeptide binding]; other site
1048245010905	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1048245010906	Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057
1048245010907	Nitronate monooxygenase; Region: NMO; pfam03060
1048245010908	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1048245010909	FMN binding site [chemical binding]; other site
1048245010910	substrate binding site [chemical binding]; other site
1048245010911	putative catalytic residue [active]
1048245010912	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1048245010913	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
1048245010914	putative di-iron ligands [ion binding]; other site
1048245010915	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1048245010916	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1048245010917	FAD binding pocket [chemical binding]; other site
1048245010918	FAD binding motif [chemical binding]; other site
1048245010919	phosphate binding motif [ion binding]; other site
1048245010920	beta-alpha-beta structure motif; other site
1048245010921	NAD(p) ribose binding residues [chemical binding]; other site
1048245010922	NAD binding pocket [chemical binding]; other site
1048245010923	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1048245010924	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1048245010925	catalytic loop [active]
1048245010926	iron binding site [ion binding]; other site
1048245010928	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1048245010929	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1048245010930	putative active site [active]
1048245010931	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
1048245010932	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1048245010933	dimer interface [polypeptide binding]; other site
1048245010934	active site
1048245010936	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245010937	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245010938	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245010939	PPE family; Region: PPE; pfam00823
1048245010940	short chain dehydrogenase; Provisional; Region: PRK07831
1048245010941	classical (c) SDRs; Region: SDR_c; cd05233
1048245010942	NAD(P) binding site [chemical binding]; other site
1048245010943	active site
1048245010944	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245010945	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245010946	active site
1048245010947	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
1048245010948	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1048245010949	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1048245010950	acyl-activating enzyme (AAE) consensus motif; other site
1048245010951	acyl-activating enzyme (AAE) consensus motif; other site
1048245010952	putative AMP binding site [chemical binding]; other site
1048245010953	putative active site [active]
1048245010954	putative CoA binding site [chemical binding]; other site
1048245010956	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245010957	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245010958	active site
1048245010959	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245010960	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1048245010961	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245010962	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245010963	active site
1048245010964	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245010965	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1048245010966	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245010967	active site
1048245010968	aspartate aminotransferase; Provisional; Region: PRK05764
1048245010969	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1048245010970	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245010971	homodimer interface [polypeptide binding]; other site
1048245010972	catalytic residue [active]
1048245010974	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1048245010975	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1048245010976	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1048245010977	putative active site [active]
1048245010978	putative NTP binding site [chemical binding]; other site
1048245010979	putative nucleic acid binding site [nucleotide binding]; other site
1048245010980	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1048245010981	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1048245010982	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
1048245010983	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
1048245010984	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
1048245010985	active site
1048245010986	Fe binding site [ion binding]; other site
1048245010988	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
1048245010989	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1048245010991	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245010992	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
1048245010993	Flavin binding site [chemical binding]; other site
1048245010994	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1048245010995	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1048245010996	FAD binding pocket [chemical binding]; other site
1048245010997	FAD binding motif [chemical binding]; other site
1048245010998	phosphate binding motif [ion binding]; other site
1048245010999	beta-alpha-beta structure motif; other site
1048245011000	NAD(p) ribose binding residues [chemical binding]; other site
1048245011001	NAD binding pocket [chemical binding]; other site
1048245011002	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1048245011003	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1048245011004	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1048245011005	catalytic loop [active]
1048245011006	iron binding site [ion binding]; other site
1048245011008	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245011009	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245011010	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1048245011011	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245011012	active site
1048245011014	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245011015	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245011016	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1048245011017	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1048245011018	DNA binding site [nucleotide binding]
1048245011019	domain linker motif; other site
1048245011020	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
1048245011021	putative dimerization interface [polypeptide binding]; other site
1048245011022	putative ligand binding site [chemical binding]; other site
1048245011023	PknH-like extracellular domain; Region: PknH_C; pfam14032
1048245011025	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1048245011026	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1048245011027	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1048245011028	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1048245011029	transmembrane helices; other site
1048245011030	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1048245011031	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1048245011032	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1048245011033	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1048245011034	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1048245011035	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1048245011036	active site
1048245011037	HIGH motif; other site
1048245011038	nucleotide binding site [chemical binding]; other site
1048245011039	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1048245011040	KMSKS motif; other site
1048245011041	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1048245011042	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1048245011043	homotrimer interaction site [polypeptide binding]; other site
1048245011044	zinc binding site [ion binding]; other site
1048245011045	CDP-binding sites; other site
1048245011046	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1048245011047	substrate binding site; other site
1048245011048	dimer interface; other site
1048245011049	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1048245011051	DNA repair protein RadA; Provisional; Region: PRK11823
1048245011052	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1048245011053	Walker A motif/ATP binding site; other site
1048245011054	ATP binding site [chemical binding]; other site
1048245011055	Walker B motif; other site
1048245011056	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1048245011058	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
1048245011059	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1048245011060	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
1048245011061	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
1048245011062	active site clefts [active]
1048245011063	zinc binding site [ion binding]; other site
1048245011064	dimer interface [polypeptide binding]; other site
1048245011067	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1048245011068	endonuclease III; Region: ENDO3c; smart00478
1048245011069	minor groove reading motif; other site
1048245011070	helix-hairpin-helix signature motif; other site
1048245011071	substrate binding pocket [chemical binding]; other site
1048245011072	active site
1048245011073	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1048245011074	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245011075	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1048245011076	catalytic site [active]
1048245011077	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1048245011078	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1048245011079	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1048245011081	Ami_2 domain; Region: Ami_2; smart00644
1048245011082	amidase catalytic site [active]
1048245011083	Zn binding residues [ion binding]; other site
1048245011084	substrate binding site [chemical binding]; other site
1048245011085	PE family; Region: PE; pfam00934
1048245011086	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1048245011087	Clp amino terminal domain; Region: Clp_N; pfam02861
1048245011088	Clp amino terminal domain; Region: Clp_N; pfam02861
1048245011089	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245011090	Walker A motif; other site
1048245011091	ATP binding site [chemical binding]; other site
1048245011092	Walker B motif; other site
1048245011093	arginine finger; other site
1048245011094	UvrB/uvrC motif; Region: UVR; pfam02151
1048245011095	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245011096	Walker A motif; other site
1048245011097	ATP binding site [chemical binding]; other site
1048245011098	Walker B motif; other site
1048245011099	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1048245011101	Lsr2; Region: Lsr2; pfam11774
1048245011102	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1048245011103	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1048245011104	dimer interface [polypeptide binding]; other site
1048245011105	putative anticodon binding site; other site
1048245011106	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1048245011107	motif 1; other site
1048245011108	dimer interface [polypeptide binding]; other site
1048245011109	active site
1048245011110	motif 2; other site
1048245011111	motif 3; other site
1048245011113	pantothenate kinase; Reviewed; Region: PRK13318
1048245011114	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1048245011115	tetramerization interface [polypeptide binding]; other site
1048245011116	active site
1048245011117	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1048245011118	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1048245011119	active site
1048245011120	ATP-binding site [chemical binding]; other site
1048245011121	pantoate-binding site; other site
1048245011122	HXXH motif; other site
1048245011123	Rossmann-like domain; Region: Rossmann-like; pfam10727
1048245011124	Uncharacterized conserved protein [Function unknown]; Region: COG5495
1048245011125	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
1048245011126	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
1048245011127	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1048245011128	catalytic center binding site [active]
1048245011129	ATP binding site [chemical binding]; other site
1048245011130	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1048245011131	homooctamer interface [polypeptide binding]; other site
1048245011132	active site
1048245011133	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1048245011134	dihydropteroate synthase; Region: DHPS; TIGR01496
1048245011135	substrate binding pocket [chemical binding]; other site
1048245011136	dimer interface [polypeptide binding]; other site
1048245011137	inhibitor binding site; inhibition site
1048245011140	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1048245011141	homodecamer interface [polypeptide binding]; other site
1048245011142	GTP cyclohydrolase I; Provisional; Region: PLN03044
1048245011143	active site
1048245011144	putative catalytic site residues [active]
1048245011145	zinc binding site [ion binding]; other site
1048245011146	GTP-CH-I/GFRP interaction surface; other site
1048245011148	FtsH Extracellular; Region: FtsH_ext; pfam06480
1048245011149	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1048245011150	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245011151	Walker A motif; other site
1048245011152	ATP binding site [chemical binding]; other site
1048245011153	Walker B motif; other site
1048245011154	arginine finger; other site
1048245011155	Peptidase family M41; Region: Peptidase_M41; pfam01434
1048245011158	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1048245011159	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1048245011160	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
1048245011161	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245011162	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1048245011164	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1048245011165	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1048245011166	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1048245011167	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1048245011168	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245011169	PPE family; Region: PPE; pfam00823
1048245011170	PE family; Region: PE; pfam00934
1048245011171	Uncharacterized conserved protein [Function unknown]; Region: COG2968
1048245011172	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1048245011174	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1048245011175	active site
1048245011177	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1048245011178	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1048245011179	Ligand Binding Site [chemical binding]; other site
1048245011180	Uncharacterized conserved protein [Function unknown]; Region: COG5282
1048245011181	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
1048245011183	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113
1048245011184	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1048245011185	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1048245011186	dimer interface [polypeptide binding]; other site
1048245011187	substrate binding site [chemical binding]; other site
1048245011188	metal binding sites [ion binding]; metal-binding site
1048245011189	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899
1048245011191	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1048245011192	Ligand binding site; other site
1048245011193	Putative Catalytic site; other site
1048245011194	DXD motif; other site
1048245011195	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
1048245011196	Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285
1048245011197	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1048245011198	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245011199	NAD(P) binding site [chemical binding]; other site
1048245011200	active site
1048245011201	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1048245011202	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1048245011203	Integrase core domain; Region: rve; pfam00665
1048245011204	Integrase core domain; Region: rve_3; cl15866
1048245011205	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1048245011206	transposase; Provisional; Region: PRK06526
1048245011207	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245011208	Walker A motif; other site
1048245011209	ATP binding site [chemical binding]; other site
1048245011210	Walker B motif; other site
1048245011212	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
1048245011213	Phage capsid family; Region: Phage_capsid; pfam05065
1048245011214	Phage capsid family; Region: Phage_capsid; pfam05065
1048245011215	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
1048245011216	Phage Terminase; Region: Terminase_1; pfam03354
1048245011217	Protein of unknown function (DUF2742); Region: DUF2742; pfam10888
1048245011218	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1048245011219	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1048245011220	active site
1048245011221	DNA binding site [nucleotide binding]
1048245011222	Int/Topo IB signature motif; other site
1048245011223	DNA polymerase III subunit delta'; Validated; Region: PRK07940
1048245011224	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1048245011225	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1048245011226	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1048245011227	dimerization interface [polypeptide binding]; other site
1048245011228	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1048245011229	cyclase homology domain; Region: CHD; cd07302
1048245011230	nucleotidyl binding site; other site
1048245011231	metal binding site [ion binding]; metal-binding site
1048245011232	dimer interface [polypeptide binding]; other site
1048245011233	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1048245011234	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1048245011235	active site
1048245011236	interdomain interaction site; other site
1048245011237	putative metal-binding site [ion binding]; other site
1048245011238	nucleotide binding site [chemical binding]; other site
1048245011239	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
1048245011240	domain I; other site
1048245011241	phosphate binding site [ion binding]; other site
1048245011242	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1048245011243	domain II; other site
1048245011244	domain III; other site
1048245011245	nucleotide binding site [chemical binding]; other site
1048245011246	DNA binding groove [nucleotide binding]
1048245011247	catalytic site [active]
1048245011248	domain IV; other site
1048245011249	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1048245011250	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1048245011251	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1048245011253	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1048245011254	DNA-binding site [nucleotide binding]; DNA binding site
1048245011255	RNA-binding motif; other site
1048245011257	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
1048245011258	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1048245011259	ATP binding site [chemical binding]; other site
1048245011260	putative Mg++ binding site [ion binding]; other site
1048245011261	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1048245011262	nucleotide binding region [chemical binding]; other site
1048245011263	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
1048245011264	PE family; Region: PE; pfam00934
1048245011265	PE family; Region: PE; pfam00934
1048245011266	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
1048245011267	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1048245011268	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1048245011269	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1048245011270	Walker A motif; other site
1048245011271	hexamer interface [polypeptide binding]; other site
1048245011272	ATP binding site [chemical binding]; other site
1048245011273	Walker B motif; other site
1048245011275	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
1048245011276	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1048245011277	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1048245011278	motif II; other site
1048245011279	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1048245011280	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1048245011281	Walker A/P-loop; other site
1048245011282	ATP binding site [chemical binding]; other site
1048245011283	Q-loop/lid; other site
1048245011284	ABC transporter signature motif; other site
1048245011285	Walker B; other site
1048245011286	D-loop; other site
1048245011287	H-loop/switch region; other site
1048245011288	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1048245011289	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1048245011290	Walker A/P-loop; other site
1048245011291	ATP binding site [chemical binding]; other site
1048245011292	Q-loop/lid; other site
1048245011293	ABC transporter signature motif; other site
1048245011294	Walker B; other site
1048245011295	D-loop; other site
1048245011296	H-loop/switch region; other site
1048245011297	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1048245011302	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1048245011303	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245011304	ABC-ATPase subunit interface; other site
1048245011305	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1048245011306	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245011307	ABC-ATPase subunit interface; other site
1048245011308	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1048245011309	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1048245011310	acetyl-CoA synthetase; Provisional; Region: PRK00174
1048245011311	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1048245011312	active site
1048245011313	CoA binding site [chemical binding]; other site
1048245011314	acyl-activating enzyme (AAE) consensus motif; other site
1048245011315	AMP binding site [chemical binding]; other site
1048245011316	acetate binding site [chemical binding]; other site
1048245011318	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
1048245011319	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1048245011321	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1048245011323	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1048245011324	putative active site [active]
1048245011325	putative CoA binding site [chemical binding]; other site
1048245011326	nudix motif; other site
1048245011327	metal binding site [ion binding]; metal-binding site
1048245011329	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1048245011330	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1048245011331	catalytic residues [active]
1048245011333	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1048245011334	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1048245011335	minor groove reading motif; other site
1048245011336	helix-hairpin-helix signature motif; other site
1048245011337	substrate binding pocket [chemical binding]; other site
1048245011338	active site
1048245011339	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1048245011342	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1048245011343	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1048245011344	ligand binding site [chemical binding]; other site
1048245011345	flexible hinge region; other site
1048245011346	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1048245011347	putative switch regulator; other site
1048245011348	non-specific DNA interactions [nucleotide binding]; other site
1048245011349	DNA binding site [nucleotide binding]
1048245011350	sequence specific DNA binding site [nucleotide binding]; other site
1048245011351	putative cAMP binding site [chemical binding]; other site
1048245011352	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1048245011353	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1048245011354	homotrimer interaction site [polypeptide binding]; other site
1048245011355	putative active site [active]
1048245011357	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
1048245011358	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1048245011359	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1048245011360	P loop; other site
1048245011361	Nucleotide binding site [chemical binding]; other site
1048245011362	DTAP/Switch II; other site
1048245011364	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1048245011365	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1048245011366	DTAP/Switch II; other site
1048245011367	Switch I; other site
1048245011368	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1048245011370	Transcription factor WhiB; Region: Whib; pfam02467
1048245011371	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1048245011372	Transglycosylase; Region: Transgly; pfam00912
1048245011373	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1048245011374	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1048245011375	phosphodiesterase YaeI; Provisional; Region: PRK11340
1048245011376	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1048245011377	putative active site [active]
1048245011378	putative metal binding site [ion binding]; other site
1048245011379	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1048245011380	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1048245011381	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1048245011382	catalytic residue [active]
1048245011383	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1048245011384	Cytochrome P450; Region: p450; cl12078
1048245011385	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1048245011386	anti sigma factor interaction site; other site
1048245011387	regulatory phosphorylation site [posttranslational modification]; other site
1048245011388	Uncharacterized conserved protein [Function unknown]; Region: COG1610
1048245011389	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1048245011390	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
1048245011391	MoxR-like ATPases [General function prediction only]; Region: COG0714
1048245011392	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245011393	Walker A motif; other site
1048245011394	ATP binding site [chemical binding]; other site
1048245011395	Walker B motif; other site
1048245011396	arginine finger; other site
1048245011397	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1048245011398	Protein of unknown function DUF58; Region: DUF58; pfam01882
1048245011399	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
1048245011400	Predicted membrane protein/domain [Function unknown]; Region: COG1714
1048245011401	glycerol kinase; Provisional; Region: glpK; PRK00047
1048245011402	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1048245011403	nucleotide binding site [chemical binding]; other site
1048245011407	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1048245011408	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1048245011409	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245011410	S-adenosylmethionine binding site [chemical binding]; other site
1048245011411	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1048245011412	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1048245011413	catalytic residue [active]
1048245011415	Uncharacterized conserved protein [Function unknown]; Region: COG4301
1048245011416	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
1048245011417	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
1048245011418	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1048245011419	putative active site [active]
1048245011420	putative dimer interface [polypeptide binding]; other site
1048245011421	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
1048245011422	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1048245011423	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
1048245011424	PknH-like extracellular domain; Region: PknH_C; pfam14032
1048245011425	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
1048245011426	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1048245011427	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1048245011429	aspartate kinase; Reviewed; Region: PRK06635
1048245011430	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1048245011431	putative nucleotide binding site [chemical binding]; other site
1048245011432	putative catalytic residues [active]
1048245011433	putative Mg ion binding site [ion binding]; other site
1048245011434	putative aspartate binding site [chemical binding]; other site
1048245011435	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1048245011436	putative allosteric regulatory site; other site
1048245011437	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1048245011438	putative allosteric regulatory residue; other site
1048245011440	2-isopropylmalate synthase; Validated; Region: PRK03739
1048245011441	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1048245011442	active site
1048245011443	catalytic residues [active]
1048245011444	metal binding site [ion binding]; metal-binding site
1048245011445	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1048245011448	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
1048245011449	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1048245011450	active site
1048245011451	catalytic site [active]
1048245011452	substrate binding site [chemical binding]; other site
1048245011453	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1048245011454	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1048245011455	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1048245011456	catalytic triad [active]
1048245011457	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1048245011458	putative active site [active]
1048245011459	recombination protein RecR; Reviewed; Region: recR; PRK00076
1048245011460	RecR protein; Region: RecR; pfam02132
1048245011461	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1048245011462	putative active site [active]
1048245011463	putative metal-binding site [ion binding]; other site
1048245011464	tetramer interface [polypeptide binding]; other site
1048245011465	hypothetical protein; Validated; Region: PRK00153
1048245011466	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1048245011467	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1048245011468	active site
1048245011469	metal binding site [ion binding]; metal-binding site
1048245011470	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
1048245011471	hydrophobic ligand binding site; other site
1048245011472	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1048245011473	FAD binding domain; Region: FAD_binding_4; pfam01565
1048245011474	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1048245011475	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245011476	S-adenosylmethionine binding site [chemical binding]; other site
1048245011477	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952
1048245011478	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245011479	Walker A motif; other site
1048245011480	ATP binding site [chemical binding]; other site
1048245011481	Walker B motif; other site
1048245011482	arginine finger; other site
1048245011483	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1048245011485	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
1048245011486	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1048245011487	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1048245011488	catalytic residue [active]
1048245011489	Cutinase; Region: Cutinase; pfam01083
1048245011490	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
1048245011491	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245011492	NAD(P) binding site [chemical binding]; other site
1048245011493	active site
1048245011494	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1048245011495	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
1048245011496	putative NAD(P) binding site [chemical binding]; other site
1048245011497	catalytic Zn binding site [ion binding]; other site
1048245011498	Uncharacterized conserved protein [Function unknown]; Region: COG3349
1048245011499	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
1048245011500	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1048245011501	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1048245011502	putative substrate translocation pore; other site
1048245011503	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1048245011504	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1048245011505	ligand binding site [chemical binding]; other site
1048245011506	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1048245011507	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
1048245011508	active site
1048245011509	nucleophile elbow; other site
1048245011512	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964
1048245011513	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1048245011514	FeS/SAM binding site; other site
1048245011515	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1048245011516	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245011517	S-adenosylmethionine binding site [chemical binding]; other site
1048245011518	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
1048245011519	nucleotide binding site [chemical binding]; other site
1048245011520	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
1048245011521	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
1048245011522	active site
1048245011523	DNA binding site [nucleotide binding]
1048245011524	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
1048245011525	DNA binding site [nucleotide binding]
1048245011526	Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827
1048245011527	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662
1048245011528	nudix motif; other site
1048245011529	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1048245011530	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1048245011532	Uncharacterized conserved protein [Function unknown]; Region: COG1839
1048245011534	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1048245011535	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1048245011536	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1048245011537	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1048245011538	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1048245011539	Uncharacterized conserved protein [Function unknown]; Region: COG3610
1048245011540	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245011541	PPE family; Region: PPE; pfam00823
1048245011542	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1048245011543	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1048245011544	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
1048245011545	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1048245011546	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1048245011547	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1048245011548	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1048245011551	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1048245011552	dimerization interface [polypeptide binding]; other site
1048245011553	putative DNA binding site [nucleotide binding]; other site
1048245011554	putative Zn2+ binding site [ion binding]; other site
1048245011557	DNA binding domain, excisionase family; Region: excise; TIGR01764
1048245011558	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1048245011559	active site
1048245011560	Int/Topo IB signature motif; other site
1048245011561	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1048245011562	nucleoside/Zn binding site; other site
1048245011563	dimer interface [polypeptide binding]; other site
1048245011564	catalytic motif [active]
1048245011566	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
1048245011567	prephenate dehydrogenase; Validated; Region: PRK06545
1048245011568	prephenate dehydrogenase; Validated; Region: PRK08507
1048245011569	Putative glycolipid-binding; Region: Glycolipid_bind; cl01425
1048245011570	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1048245011571	ABC-ATPase subunit interface; other site
1048245011572	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
1048245011573	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1048245011574	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1048245011575	Walker A/P-loop; other site
1048245011576	ATP binding site [chemical binding]; other site
1048245011577	Q-loop/lid; other site
1048245011578	ABC transporter signature motif; other site
1048245011579	Walker B; other site
1048245011580	D-loop; other site
1048245011581	H-loop/switch region; other site
1048245011584	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1048245011585	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
1048245011586	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
1048245011587	putative active site [active]
1048245011588	putative substrate binding site [chemical binding]; other site
1048245011589	ATP binding site [chemical binding]; other site
1048245011591	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
1048245011592	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1048245011593	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
1048245011595	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1048245011596	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1048245011597	dimerization interface [polypeptide binding]; other site
1048245011598	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1048245011599	dimer interface [polypeptide binding]; other site
1048245011600	phosphorylation site [posttranslational modification]
1048245011601	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1048245011602	ATP binding site [chemical binding]; other site
1048245011603	Mg2+ binding site [ion binding]; other site
1048245011604	G-X-G motif; other site
1048245011605	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1048245011606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1048245011607	active site
1048245011608	phosphorylation site [posttranslational modification]
1048245011609	intermolecular recognition site; other site
1048245011610	dimerization interface [polypeptide binding]; other site
1048245011611	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1048245011612	DNA binding site [nucleotide binding]
1048245011614	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1048245011615	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1048245011616	SnoaL-like domain; Region: SnoaL_2; pfam12680
1048245011617	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1048245011618	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1048245011619	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1048245011620	homodimer interface [polypeptide binding]; other site
1048245011621	catalytic residue [active]
1048245011623	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1048245011624	TIGR03086 family protein; Region: TIGR03086
1048245011625	enoyl-CoA hydratase; Provisional; Region: PRK06142
1048245011626	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1048245011627	substrate binding site [chemical binding]; other site
1048245011628	oxyanion hole (OAH) forming residues; other site
1048245011629	trimer interface [polypeptide binding]; other site
1048245011630	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1048245011631	Beta-lactamase; Region: Beta-lactamase; pfam00144
1048245011632	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1048245011633	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1048245011634	active site
1048245011635	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1048245011636	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1048245011637	NAD(P) binding site [chemical binding]; other site
1048245011638	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1048245011639	cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976
1048245011640	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1048245011641	catalytic residue [active]
1048245011642	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
1048245011643	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1048245011644	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1048245011645	Walker A/P-loop; other site
1048245011646	ATP binding site [chemical binding]; other site
1048245011647	Q-loop/lid; other site
1048245011648	ABC transporter signature motif; other site
1048245011649	Walker B; other site
1048245011650	D-loop; other site
1048245011651	H-loop/switch region; other site
1048245011653	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1048245011654	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1048245011655	active site
1048245011656	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1048245011657	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1048245011658	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1048245011659	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
1048245011660	NAD binding site [chemical binding]; other site
1048245011661	substrate binding site [chemical binding]; other site
1048245011662	active site
1048245011663	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1048245011664	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1048245011665	active site
1048245011666	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1048245011667	Peptidase family M23; Region: Peptidase_M23; pfam01551
1048245011668	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1048245011669	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1048245011670	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892
1048245011671	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1048245011672	Predicted membrane protein [Function unknown]; Region: COG2246
1048245011673	GtrA-like protein; Region: GtrA; pfam04138
1048245011674	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1048245011675	FAD binding domain; Region: FAD_binding_4; pfam01565
1048245011676	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1048245011677	short chain dehydrogenase; Provisional; Region: PRK07904
1048245011678	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1048245011679	NAD(P) binding site [chemical binding]; other site
1048245011680	active site
1048245011682	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
1048245011683	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
1048245011684	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
1048245011687	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
1048245011688	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
1048245011689	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1048245011690	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
1048245011691	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1048245011692	FAD binding site [chemical binding]; other site
1048245011693	substrate binding site [chemical binding]; other site
1048245011694	catalytic residues [active]
1048245011695	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1048245011696	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1048245011697	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1048245011698	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245011699	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245011700	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1048245011701	active site
1048245011702	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1048245011703	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1048245011704	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245011705	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1048245011707	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
1048245011708	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1048245011709	acyl-activating enzyme (AAE) consensus motif; other site
1048245011710	active site
1048245011711	Cutinase; Region: Cutinase; pfam01083
1048245011712	Predicted esterase [General function prediction only]; Region: COG0627
1048245011714	Putative esterase; Region: Esterase; pfam00756
1048245011715	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
1048245011717	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1048245011718	active site
1048245011719	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1048245011720	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1048245011721	active site
1048245011722	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1048245011723	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1048245011724	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1048245011725	UDP-galactopyranose mutase; Region: GLF; pfam03275
1048245011726	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1048245011727	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1048245011728	amidase catalytic site [active]
1048245011729	Zn binding residues [ion binding]; other site
1048245011730	substrate binding site [chemical binding]; other site
1048245011731	LGFP repeat; Region: LGFP; pfam08310
1048245011733	PE family; Region: PE; pfam00934
1048245011734	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1048245011735	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1048245011736	active site
1048245011737	motif I; other site
1048245011738	motif II; other site
1048245011739	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1048245011740	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1048245011741	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1048245011742	putative acyl-acceptor binding pocket; other site
1048245011743	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1048245011744	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1048245011745	putative acyl-acceptor binding pocket; other site
1048245011746	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1048245011747	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1048245011748	putative acyl-acceptor binding pocket; other site
1048245011749	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
1048245011750	Phosphotransferase enzyme family; Region: APH; pfam01636
1048245011751	active site
1048245011752	ATP binding site [chemical binding]; other site
1048245011753	antibiotic binding site [chemical binding]; other site
1048245011754	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1048245011755	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1048245011756	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1048245011757	dimerization interface [polypeptide binding]; other site
1048245011758	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1048245011759	iron-sulfur cluster [ion binding]; other site
1048245011760	[2Fe-2S] cluster binding site [ion binding]; other site
1048245011762	Condensation domain; Region: Condensation; pfam00668
1048245011763	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
1048245011764	PE-PPE domain; Region: PE-PPE; pfam08237
1048245011765	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1048245011766	peptide synthase; Provisional; Region: PRK12316
1048245011768	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1048245011769	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1048245011770	active site
1048245011771	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1048245011772	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1048245011773	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1048245011774	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1048245011775	Enoylreductase; Region: PKS_ER; smart00829
1048245011776	NAD(P) binding site [chemical binding]; other site
1048245011777	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1048245011778	KR domain; Region: KR; pfam08659
1048245011779	putative NADP binding site [chemical binding]; other site
1048245011780	active site
1048245011781	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1048245011784	acyl-CoA synthetase; Validated; Region: PRK05850
1048245011785	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1048245011786	acyl-activating enzyme (AAE) consensus motif; other site
1048245011787	active site
1048245011788	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1048245011789	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1048245011790	Probable transposase; Region: OrfB_IS605; pfam01385
1048245011791	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
1048245011792	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1048245011793	catalytic residues [active]
1048245011794	catalytic nucleophile [active]
1048245011796	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1048245011797	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1048245011798	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1048245011799	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245011800	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
1048245011801	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1048245011802	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1048245011803	Cupin domain; Region: Cupin_2; cl17218
1048245011804	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1048245011805	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1048245011806	seryl-tRNA synthetase; Provisional; Region: PRK05431
1048245011807	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1048245011808	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1048245011809	dimer interface [polypeptide binding]; other site
1048245011810	active site
1048245011811	motif 1; other site
1048245011812	motif 2; other site
1048245011813	motif 3; other site
1048245011815	Septum formation; Region: Septum_form; pfam13845
1048245011816	Septum formation; Region: Septum_form; pfam13845
1048245011817	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
1048245011819	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1048245011820	catalytic core [active]
1048245011822	prephenate dehydratase; Provisional; Region: PRK11898
1048245011823	Prephenate dehydratase; Region: PDT; pfam00800
1048245011824	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1048245011825	putative L-Phe binding site [chemical binding]; other site
1048245011827	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1048245011828	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1048245011829	Ferritin-like domain; Region: Ferritin; pfam00210
1048245011830	ferroxidase diiron center [ion binding]; other site
1048245011831	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
1048245011832	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1048245011833	putative active site [active]
1048245011834	catalytic site [active]
1048245011835	putative metal binding site [ion binding]; other site
1048245011836	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
1048245011837	putative transposase OrfB; Reviewed; Region: PHA02517
1048245011838	HTH-like domain; Region: HTH_21; pfam13276
1048245011839	Integrase core domain; Region: rve; pfam00665
1048245011840	Integrase core domain; Region: rve_3; pfam13683
1048245011841	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1048245011843	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1048245011844	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1048245011845	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1048245011847	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1048245011848	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1048245011849	Predicted membrane protein [Function unknown]; Region: COG2119
1048245011850	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1048245011851	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1048245011852	Fimbrial protein; Region: Fimbrial; cl01416
1048245011853	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1048245011854	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1048245011855	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1048245011856	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1048245011857	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1048245011858	hypothetical protein; Provisional; Region: PRK07945
1048245011859	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1048245011860	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1048245011861	active site
1048245011862	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1048245011863	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1048245011864	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1048245011865	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1048245011866	active site
1048245011867	dimer interface [polypeptide binding]; other site
1048245011868	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1048245011869	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1048245011870	active site
1048245011871	FMN binding site [chemical binding]; other site
1048245011872	substrate binding site [chemical binding]; other site
1048245011873	3Fe-4S cluster binding site [ion binding]; other site
1048245011874	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1048245011875	domain interface; other site
1048245011876	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1048245011878	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1048245011879	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
1048245011880	EspG family; Region: ESX-1_EspG; pfam14011
1048245011881	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
1048245011882	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245011883	Walker A motif; other site
1048245011884	ATP binding site [chemical binding]; other site
1048245011885	Walker B motif; other site
1048245011886	arginine finger; other site
1048245011888	Protein of unknown function (DUF690); Region: DUF690; pfam05108
1048245011889	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1048245011890	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1048245011892	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1048245011893	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1048245011894	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1048245011897	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1048245011898	PPE family; Region: PPE; pfam00823
1048245011899	Proteins of 100 residues with WXG; Region: WXG100; cl02005
1048245011900	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1048245011901	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1048245011902	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1048245011903	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
1048245011904	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
1048245011905	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1048245011906	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1048245011907	active site
1048245011908	catalytic residues [active]
1048245011909	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
1048245011910	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1048245011911	Walker A motif; other site
1048245011912	ATP binding site [chemical binding]; other site
1048245011913	Walker B motif; other site
1048245011914	arginine finger; other site
1048245011916	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
1048245011917	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1048245011918	catalytic residues [active]
1048245011919	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1048245011920	active site
1048245011921	catalytic residues [active]
1048245011924	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1048245011925	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1048245011926	EspG family; Region: ESX-1_EspG; pfam14011
1048245011927	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1048245011928	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1048245011929	PPE family; Region: PPE; pfam00823
1048245011930	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1048245011931	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1048245011932	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1048245011933	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1048245011934	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1048245011937	Protein of unknown function (DUF690); Region: DUF690; pfam05108
1048245011938	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1048245011939	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1048245011940	catalytic residue [active]
1048245011941	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1048245011942	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
1048245011943	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1048245011944	active site
1048245011945	NTP binding site [chemical binding]; other site
1048245011946	metal binding triad [ion binding]; metal-binding site
1048245011947	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1048245011948	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1048245011949	Zn2+ binding site [ion binding]; other site
1048245011950	Mg2+ binding site [ion binding]; other site
1048245011951	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1048245011956	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1048245011957	active site
1048245011958	Ap6A binding site [chemical binding]; other site
1048245011959	nudix motif; other site
1048245011960	metal binding site [ion binding]; metal-binding site
1048245011962	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1048245011963	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1048245011964	RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643
1048245011965	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1048245011966	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1048245011967	DNA binding residues [nucleotide binding]
1048245011968	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1048245011969	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1048245011970	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1048245011972	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1048245011973	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1048245011974	catalytic residues [active]
1048245011976	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1048245011977	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1048245011978	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1048245011979	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1048245011980	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1048245011981	active site
1048245011982	metal binding site [ion binding]; metal-binding site
1048245011983	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1048245011984	ParB-like nuclease domain; Region: ParB; smart00470
1048245011985	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1048245011986	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1048245011987	P-loop; other site
1048245011988	Magnesium ion binding site [ion binding]; other site
1048245011989	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1048245011990	Magnesium ion binding site [ion binding]; other site
1048245011991	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
1048245011992	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1048245011993	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1048245011994	G-X-X-G motif; other site
1048245011995	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1048245011996	RxxxH motif; other site
1048245011997	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
1048245011998	Uncharacterized conserved protein [Function unknown]; Region: COG0759
1048245011999	Ribonuclease P; Region: Ribonuclease_P; cl00457
1048245012001	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399