-- dump date 20140619_151729 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1205676000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1205676000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676000003 Walker A motif; other site 1205676000004 ATP binding site [chemical binding]; other site 1205676000005 Walker B motif; other site 1205676000006 arginine finger; other site 1205676000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1205676000008 DnaA box-binding interface [nucleotide binding]; other site 1205676000009 Transposase; Region: HTH_Tnp_1; pfam01527 1205676000010 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205676000011 HTH-like domain; Region: HTH_21; pfam13276 1205676000012 Integrase core domain; Region: rve; pfam00665 1205676000013 Integrase core domain; Region: rve_3; pfam13683 1205676000014 DNA polymerase III subunit beta; Validated; Region: PRK07761 1205676000015 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1205676000016 putative DNA binding surface [nucleotide binding]; other site 1205676000017 dimer interface [polypeptide binding]; other site 1205676000018 beta-clamp/clamp loader binding surface; other site 1205676000019 beta-clamp/translesion DNA polymerase binding surface; other site 1205676000020 recF protein; Region: recf; TIGR00611 1205676000021 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1205676000022 Walker A/P-loop; other site 1205676000023 ATP binding site [chemical binding]; other site 1205676000024 Q-loop/lid; other site 1205676000025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205676000026 ABC transporter signature motif; other site 1205676000027 Walker B; other site 1205676000028 D-loop; other site 1205676000029 H-loop/switch region; other site 1205676000030 hypothetical protein; Provisional; Region: PRK03195 1205676000031 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1205676000032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205676000033 Mg2+ binding site [ion binding]; other site 1205676000034 G-X-G motif; other site 1205676000035 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1205676000036 anchoring element; other site 1205676000037 dimer interface [polypeptide binding]; other site 1205676000038 ATP binding site [chemical binding]; other site 1205676000039 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1205676000040 active site 1205676000041 putative metal-binding site [ion binding]; other site 1205676000042 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1205676000043 DNA gyrase subunit A; Validated; Region: PRK05560 1205676000044 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1205676000045 CAP-like domain; other site 1205676000046 active site 1205676000047 primary dimer interface [polypeptide binding]; other site 1205676000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205676000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205676000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205676000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205676000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205676000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1205676000054 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1205676000055 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1205676000056 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1205676000057 active site 1205676000058 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1205676000059 putative septation inhibitor protein; Reviewed; Region: PRK00159 1205676000060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1205676000061 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1205676000062 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1205676000063 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1205676000064 glutamine binding [chemical binding]; other site 1205676000065 catalytic triad [active] 1205676000066 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205676000067 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205676000068 active site 1205676000069 ATP binding site [chemical binding]; other site 1205676000070 substrate binding site [chemical binding]; other site 1205676000071 activation loop (A-loop); other site 1205676000072 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1205676000073 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205676000074 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205676000075 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205676000076 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205676000077 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205676000078 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205676000079 active site 1205676000080 ATP binding site [chemical binding]; other site 1205676000081 substrate binding site [chemical binding]; other site 1205676000082 activation loop (A-loop); other site 1205676000083 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1205676000084 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1205676000085 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1205676000086 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1205676000087 active site 1205676000088 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205676000089 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205676000090 phosphopeptide binding site; other site 1205676000091 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1205676000092 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205676000093 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205676000094 phosphopeptide binding site; other site 1205676000095 Nitronate monooxygenase; Region: NMO; pfam03060 1205676000096 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1205676000097 FMN binding site [chemical binding]; other site 1205676000098 substrate binding site [chemical binding]; other site 1205676000099 putative catalytic residue [active] 1205676000100 Transcription factor WhiB; Region: Whib; pfam02467 1205676000101 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205676000102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205676000103 non-specific DNA binding site [nucleotide binding]; other site 1205676000104 salt bridge; other site 1205676000105 sequence-specific DNA binding site [nucleotide binding]; other site 1205676000106 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205676000107 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205676000108 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1205676000109 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1205676000110 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1205676000111 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1205676000112 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1205676000113 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1205676000114 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1205676000115 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1205676000116 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205676000117 catalytic residue [active] 1205676000118 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1205676000119 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1205676000120 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1205676000121 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205676000122 acyl-activating enzyme (AAE) consensus motif; other site 1205676000123 active site 1205676000124 TIGR03084 family protein; Region: TIGR03084 1205676000125 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1205676000126 Wyosine base formation; Region: Wyosine_form; pfam08608 1205676000127 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205676000128 hypothetical protein; Validated; Region: PRK00228 1205676000129 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1205676000130 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1205676000131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205676000132 active site 1205676000133 HIGH motif; other site 1205676000134 nucleotide binding site [chemical binding]; other site 1205676000135 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1205676000136 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205676000137 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205676000138 active site 1205676000139 KMSKS motif; other site 1205676000140 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1205676000141 tRNA binding surface [nucleotide binding]; other site 1205676000142 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205676000143 MarR family; Region: MarR; pfam01047 1205676000144 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205676000145 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205676000146 DNA-binding site [nucleotide binding]; DNA binding site 1205676000147 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1205676000148 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205676000149 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676000150 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1205676000151 inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450 1205676000152 Predicted transcriptional regulators [Transcription]; Region: COG1695 1205676000153 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1205676000154 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1205676000155 Transglycosylase; Region: Transgly; pfam00912 1205676000156 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1205676000157 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1205676000158 Predicted integral membrane protein [Function unknown]; Region: COG5650 1205676000159 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1205676000160 conserved cys residue [active] 1205676000161 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1205676000162 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1205676000163 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1205676000164 dimer interface [polypeptide binding]; other site 1205676000165 ssDNA binding site [nucleotide binding]; other site 1205676000166 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1205676000167 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1205676000168 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1205676000169 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1205676000170 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1205676000171 replicative DNA helicase; Validated; Region: PRK07773 1205676000172 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1205676000173 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1205676000174 Walker A motif; other site 1205676000175 ATP binding site [chemical binding]; other site 1205676000176 Walker B motif; other site 1205676000177 DNA binding loops [nucleotide binding] 1205676000178 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1205676000179 protein-splicing catalytic site; other site 1205676000180 thioester formation/cholesterol transfer; other site 1205676000181 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1205676000182 protein-splicing catalytic site; other site 1205676000183 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1205676000184 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1205676000185 ADP-ribose binding site [chemical binding]; other site 1205676000186 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 [General function prediction only]; Region: COG2110 1205676000187 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1205676000188 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205676000189 FAD binding domain; Region: FAD_binding_4; pfam01565 1205676000190 Berberine and berberine like; Region: BBE; pfam08031 1205676000191 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1205676000192 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1205676000193 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1205676000194 DNA binding residues [nucleotide binding] 1205676000195 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type e : enzyme 1205676000196 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 12775759, 15525680, 17443846 1205676000197 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 12775759, 15525680, 17443846 1205676000198 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1205676000199 homotetrameric interface [polypeptide binding]; other site 1205676000200 putative active site [active] 1205676000201 metal binding site [ion binding]; metal-binding site 1205676000202 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1205676000203 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 1205676000204 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676000205 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676000206 short chain dehydrogenase; Provisional; Region: PRK06197 1205676000207 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1205676000208 putative NAD(P) binding site [chemical binding]; other site 1205676000209 active site 1205676000210 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1205676000211 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1205676000212 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1205676000213 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1205676000214 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1205676000215 dimer interface [polypeptide binding]; other site 1205676000216 active site 1205676000217 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1205676000218 folate binding site [chemical binding]; other site 1205676000219 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1205676000220 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1205676000221 putative NTP binding site [chemical binding]; other site 1205676000222 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1205676000223 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1205676000224 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205676000225 Walker A/P-loop; other site 1205676000226 ATP binding site [chemical binding]; other site 1205676000227 Q-loop/lid; other site 1205676000228 ABC transporter signature motif; other site 1205676000229 Walker B; other site 1205676000230 D-loop; other site 1205676000231 H-loop/switch region; other site 1205676000232 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205676000233 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205676000234 ligand binding site [chemical binding]; other site 1205676000235 flexible hinge region; other site 1205676000236 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1205676000237 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205676000238 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1205676000239 active site 1205676000240 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1205676000241 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205676000242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676000243 homodimer interface [polypeptide binding]; other site 1205676000244 catalytic residue [active] 1205676000245 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676000246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676000247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676000248 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1205676000249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205676000250 dimerization interface [polypeptide binding]; other site 1205676000251 putative DNA binding site [nucleotide binding]; other site 1205676000252 putative Zn2+ binding site [ion binding]; other site 1205676000253 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1205676000254 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205676000255 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1205676000256 NADH dehydrogenase; Region: NADHdh; cl00469 1205676000257 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; COG4237 1205676000258 hydrogenase 4 subunit F; Validated; Region: PRK06458 1205676000259 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205676000260 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1205676000261 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1205676000262 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1205676000263 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1205676000264 putative hydrophobic ligand binding site [chemical binding]; other site 1205676000265 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1205676000266 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205676000267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205676000268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676000269 S-adenosylmethionine binding site [chemical binding]; other site 1205676000270 Predicted membrane protein [Function unknown]; Region: COG3305 1205676000271 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1205676000272 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1205676000273 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1205676000274 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1205676000275 metal-binding site [ion binding] 1205676000276 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205676000277 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205676000278 Predicted integral membrane protein [Function unknown]; Region: COG5660 1205676000279 Putative zinc-finger; Region: zf-HC2; pfam13490 1205676000280 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205676000281 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205676000282 active site 1205676000283 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676000284 PPE family; Region: PPE; pfam00823 1205676000285 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1205676000286 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1205676000287 FcoT-like thioesterase domain; Region: FcoT; pfam10862 1205676000288 acyl-CoA synthetase; Validated; Region: PRK05857 1205676000289 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676000290 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1205676000291 acyl-activating enzyme (AAE) consensus motif; other site 1205676000292 acyl-activating enzyme (AAE) consensus motif; other site 1205676000293 AMP binding site [chemical binding]; other site 1205676000294 active site 1205676000295 CoA binding site [chemical binding]; other site 1205676000296 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205676000297 AMP-binding enzyme; Region: AMP-binding; pfam00501 1205676000298 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676000299 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676000300 acyl-activating enzyme (AAE) consensus motif; other site 1205676000301 acyl-activating enzyme (AAE) consensus motif; other site 1205676000302 active site 1205676000303 AMP binding site [chemical binding]; other site 1205676000304 CoA binding site [chemical binding]; other site 1205676000305 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205676000306 Condensation domain; Region: Condensation; pfam00668 1205676000307 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205676000308 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1205676000309 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205676000310 acyl-activating enzyme (AAE) consensus motif; other site 1205676000311 AMP binding site [chemical binding]; other site 1205676000312 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205676000313 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1205676000314 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1205676000315 putative NAD(P) binding site [chemical binding]; other site 1205676000316 active site 1205676000317 putative substrate binding site [chemical binding]; other site 1205676000318 Predicted membrane protein [Function unknown]; Region: COG3336 1205676000319 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1205676000320 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1205676000321 metal-binding site [ion binding] 1205676000322 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205676000323 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205676000324 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205676000325 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205676000326 ligand binding site [chemical binding]; other site 1205676000327 flexible hinge region; other site 1205676000328 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1205676000329 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1205676000330 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1205676000331 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1205676000332 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205676000333 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1205676000334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205676000335 motif II; other site 1205676000336 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1205676000337 PE family; Region: PE; pfam00934 1205676000338 Rhomboid family; Region: Rhomboid; pfam01694 1205676000339 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1205676000340 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1205676000341 active site 1205676000342 catalytic triad [active] 1205676000343 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205676000344 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1205676000345 NADP-binding site; other site 1205676000346 homotetramer interface [polypeptide binding]; other site 1205676000347 substrate binding site [chemical binding]; other site 1205676000348 homodimer interface [polypeptide binding]; other site 1205676000349 active site 1205676000350 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1205676000351 dimer interface [polypeptide binding]; other site 1205676000352 active site 1205676000353 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1205676000354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205676000355 active site 1205676000356 motif I; other site 1205676000357 motif II; other site 1205676000358 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1205676000359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1205676000360 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1205676000361 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205676000362 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205676000363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205676000364 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1205676000365 dimerization interface [polypeptide binding]; other site 1205676000366 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1205676000367 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205676000368 PYR/PP interface [polypeptide binding]; other site 1205676000369 dimer interface [polypeptide binding]; other site 1205676000370 TPP binding site [chemical binding]; other site 1205676000371 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205676000372 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1205676000373 TPP-binding site; other site 1205676000374 dimer interface [polypeptide binding]; other site 1205676000375 acyl-CoA synthetase; Validated; Region: PRK05852 1205676000376 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676000377 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 1205676000378 acyl-activating enzyme (AAE) consensus motif; other site 1205676000379 acyl-activating enzyme (AAE) consensus motif; other site 1205676000380 putative AMP binding site [chemical binding]; other site 1205676000381 putative active site [active] 1205676000382 putative CoA binding site [chemical binding]; other site 1205676000383 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1205676000384 elongation factor G; Reviewed; Region: PRK12740 1205676000385 G1 box; other site 1205676000386 putative GEF interaction site [polypeptide binding]; other site 1205676000387 GTP/Mg2+ binding site [chemical binding]; other site 1205676000388 Switch I region; other site 1205676000389 G2 box; other site 1205676000390 G3 box; other site 1205676000391 Switch II region; other site 1205676000392 G4 box; other site 1205676000393 G5 box; other site 1205676000394 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1205676000395 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1205676000396 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1205676000397 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1205676000398 PE family; Region: PE; pfam00934 1205676000399 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1205676000400 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1205676000401 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1205676000402 trehalose synthase; Region: treS_nterm; TIGR02456 1205676000403 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1205676000404 active site 1205676000405 catalytic site [active] 1205676000406 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1205676000407 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1205676000408 Predicted membrane protein [Function unknown]; Region: COG3619 1205676000409 Predicted esterase [General function prediction only]; Region: COG0627 1205676000410 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1205676000411 putative active site [active] 1205676000412 putative catalytic site [active] 1205676000413 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676000414 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676000415 active site 1205676000416 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1205676000417 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205676000418 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1205676000419 Coenzyme A binding pocket [chemical binding]; other site 1205676000420 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676000421 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1205676000422 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676000423 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676000424 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676000425 Cytochrome P450; Region: p450; cl12078 1205676000426 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1205676000427 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205676000428 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1205676000429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676000430 NAD(P) binding site [chemical binding]; other site 1205676000431 active site 1205676000432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1205676000433 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1205676000434 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1205676000435 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1205676000436 minor groove reading motif; other site 1205676000437 helix-hairpin-helix signature motif; other site 1205676000438 active site 1205676000439 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1205676000440 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1205676000441 Cl- selectivity filter; other site 1205676000442 Cl- binding residues [ion binding]; other site 1205676000443 pore gating glutamate residue; other site 1205676000444 dimer interface [polypeptide binding]; other site 1205676000445 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676000446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676000447 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205676000448 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205676000449 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205676000450 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205676000451 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1205676000452 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1205676000453 NAD(P) binding site [chemical binding]; other site 1205676000454 catalytic residues [active] 1205676000455 short chain dehydrogenase; Provisional; Region: PRK07791 1205676000456 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1205676000457 NAD binding site [chemical binding]; other site 1205676000458 homodimer interface [polypeptide binding]; other site 1205676000459 active site 1205676000460 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205676000461 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1205676000462 NAD(P) binding site [chemical binding]; other site 1205676000463 PE family; Region: PE; pfam00934 1205676000464 PE-PPE domain; Region: PE-PPE; pfam08237 1205676000465 PE family; Region: PE; pfam00934 1205676000466 PE-PPE domain; Region: PE-PPE; pfam08237 1205676000467 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1205676000468 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1205676000469 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1205676000470 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676000471 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1205676000472 FAD binding site [chemical binding]; other site 1205676000473 substrate binding site [chemical binding]; other site 1205676000474 catalytic base [active] 1205676000475 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1205676000476 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10510226; Product type pe : putative enzyme 1205676000477 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15525680; Product type pe : putative enzyme 1205676000478 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1205676000479 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1205676000480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676000481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676000482 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1205676000483 PE family; Region: PE; pfam00934 1205676000484 PE-PPE domain; Region: PE-PPE; pfam08237 1205676000485 PE family; Region: PE; pfam00934 1205676000486 PE-PPE domain; Region: PE-PPE; pfam08237 1205676000487 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205676000488 FAD binding domain; Region: FAD_binding_4; pfam01565 1205676000489 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1205676000490 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205676000491 NAD(P) binding site [chemical binding]; other site 1205676000492 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1205676000493 active site 1205676000494 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1205676000495 putative hydrophobic ligand binding site [chemical binding]; other site 1205676000496 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1205676000497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205676000498 DNA-binding site [nucleotide binding]; DNA binding site 1205676000499 FCD domain; Region: FCD; pfam07729 1205676000500 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1205676000501 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676000502 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1205676000503 acyl-activating enzyme (AAE) consensus motif; other site 1205676000504 acyl-activating enzyme (AAE) consensus motif; other site 1205676000505 putative AMP binding site [chemical binding]; other site 1205676000506 putative active site [active] 1205676000507 putative CoA binding site [chemical binding]; other site 1205676000508 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205676000509 Permease; Region: Permease; pfam02405 1205676000510 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205676000511 Permease; Region: Permease; pfam02405 1205676000512 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676000513 mce related protein; Region: MCE; pfam02470 1205676000514 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205676000515 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676000516 mce related protein; Region: MCE; pfam02470 1205676000517 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205676000518 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676000519 mce related protein; Region: MCE; pfam02470 1205676000520 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676000521 mce related protein; Region: MCE; pfam02470 1205676000522 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676000523 mce related protein; Region: MCE; pfam02470 1205676000524 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676000525 mce related protein; Region: MCE; pfam02470 1205676000526 RDD family; Region: RDD; pfam06271 1205676000527 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1205676000528 Predicted membrane protein [Function unknown]; Region: COG1511 1205676000529 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1205676000530 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1205676000531 Pirin-related protein [General function prediction only]; Region: COG1741 1205676000532 Pirin; Region: Pirin; pfam02678 1205676000533 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1205676000534 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205676000535 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205676000536 DNA binding residues [nucleotide binding] 1205676000537 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205676000538 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1205676000539 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205676000540 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1205676000541 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1205676000542 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1205676000543 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1205676000544 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1205676000545 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1205676000546 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1205676000547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676000548 S-adenosylmethionine binding site [chemical binding]; other site 1205676000549 SPW repeat; Region: SPW; pfam03779 1205676000550 SPW repeat; Region: SPW; pfam03779 1205676000551 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1205676000552 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1205676000553 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1205676000554 putative homodimer interface [polypeptide binding]; other site 1205676000555 putative homotetramer interface [polypeptide binding]; other site 1205676000556 putative allosteric switch controlling residues; other site 1205676000557 putative metal binding site [ion binding]; other site 1205676000558 putative homodimer-homodimer interface [polypeptide binding]; other site 1205676000559 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1205676000560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676000561 putative substrate translocation pore; other site 1205676000562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1205676000563 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1205676000564 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205676000565 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205676000566 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205676000567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205676000568 Walker A/P-loop; other site 1205676000569 ATP binding site [chemical binding]; other site 1205676000570 Q-loop/lid; other site 1205676000571 ABC transporter signature motif; other site 1205676000572 Walker B; other site 1205676000573 D-loop; other site 1205676000574 H-loop/switch region; other site 1205676000575 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205676000576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205676000577 Walker A/P-loop; other site 1205676000578 ATP binding site [chemical binding]; other site 1205676000579 Q-loop/lid; other site 1205676000580 ABC transporter signature motif; other site 1205676000581 Walker B; other site 1205676000582 D-loop; other site 1205676000583 H-loop/switch region; other site 1205676000584 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205676000585 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205676000586 dimerization interface [polypeptide binding]; other site 1205676000587 DNA binding residues [nucleotide binding] 1205676000588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676000589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676000590 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1205676000591 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205676000592 molybdopterin cofactor binding site; other site 1205676000593 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205676000594 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1205676000595 putative molybdopterin cofactor binding site; other site 1205676000596 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1205676000597 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1205676000598 active site 1205676000599 Zn binding site [ion binding]; other site 1205676000600 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205676000601 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1205676000602 Predicted integral membrane protein [Function unknown]; Region: COG0392 1205676000603 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1205676000604 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1205676000605 MMPL family; Region: MMPL; pfam03176 1205676000606 MMPL family; Region: MMPL; pfam03176 1205676000607 LabA_like proteins; Region: LabA_like; cd06167 1205676000608 putative metal binding site [ion binding]; other site 1205676000609 Putative methyltransferase; Region: Methyltransf_4; pfam02390 1205676000610 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1205676000611 active site 1205676000612 substrate-binding site [chemical binding]; other site 1205676000613 metal-binding site [ion binding] 1205676000614 GTP binding site [chemical binding]; other site 1205676000615 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1205676000616 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205676000617 active site 1205676000618 nucleotide binding site [chemical binding]; other site 1205676000619 HIGH motif; other site 1205676000620 KMSKS motif; other site 1205676000621 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1205676000622 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1205676000623 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1205676000624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205676000625 FeS/SAM binding site; other site 1205676000626 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1205676000627 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676000628 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1205676000629 acyl-activating enzyme (AAE) consensus motif; other site 1205676000630 acyl-activating enzyme (AAE) consensus motif; other site 1205676000631 putative AMP binding site [chemical binding]; other site 1205676000632 putative active site [active] 1205676000633 putative CoA binding site [chemical binding]; other site 1205676000634 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676000635 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676000636 active site 1205676000637 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1205676000638 putative active site [active] 1205676000639 putative catalytic site [active] 1205676000640 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205676000641 active site 2 [active] 1205676000642 active site 1 [active] 1205676000643 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205676000644 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205676000645 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1205676000646 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1205676000647 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1205676000648 Moco binding site; other site 1205676000649 metal coordination site [ion binding]; other site 1205676000650 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205676000651 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205676000652 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205676000653 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205676000654 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1205676000655 enoyl-CoA hydratase; Provisional; Region: PRK08252 1205676000656 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676000657 substrate binding site [chemical binding]; other site 1205676000658 oxyanion hole (OAH) forming residues; other site 1205676000659 trimer interface [polypeptide binding]; other site 1205676000660 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1205676000661 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1205676000662 NAD binding site [chemical binding]; other site 1205676000663 catalytic residues [active] 1205676000664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676000665 S-adenosylmethionine binding site [chemical binding]; other site 1205676000666 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205676000667 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205676000668 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1205676000669 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1205676000670 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205676000671 putative active site [active] 1205676000672 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1205676000673 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1205676000674 active site 1205676000675 substrate binding pocket [chemical binding]; other site 1205676000676 homodimer interaction site [polypeptide binding]; other site 1205676000677 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676000678 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1205676000679 active site 1205676000680 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676000681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676000682 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1205676000683 active site 1205676000684 diiron metal binding site [ion binding]; other site 1205676000685 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1205676000686 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1205676000687 NAD(P) binding site [chemical binding]; other site 1205676000688 catalytic residues [active] 1205676000689 Lipase maturation factor; Region: LMF1; pfam06762 1205676000690 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1205676000691 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1205676000692 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1205676000693 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1205676000694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676000695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676000696 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205676000697 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205676000698 MaoC like domain; Region: MaoC_dehydratas; pfam01575 1205676000699 active site 2 [active] 1205676000700 active site 1 [active] 1205676000701 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1205676000702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676000703 NAD(P) binding site [chemical binding]; other site 1205676000704 active site 1205676000705 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1205676000706 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205676000707 dimer interface [polypeptide binding]; other site 1205676000708 active site 1205676000709 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1205676000710 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1205676000711 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1205676000712 FAD binding site [chemical binding]; other site 1205676000713 substrate binding site [chemical binding]; other site 1205676000714 catalytic residues [active] 1205676000715 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1205676000716 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1205676000717 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1205676000718 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205676000719 catalytic loop [active] 1205676000720 iron binding site [ion binding]; other site 1205676000721 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1205676000722 L-aspartate oxidase; Provisional; Region: PRK06175 1205676000723 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1205676000724 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1205676000725 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1205676000726 putative dimer interface [polypeptide binding]; other site 1205676000727 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1205676000728 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205676000729 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1205676000730 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1205676000731 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1205676000732 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1205676000733 homotrimer interface [polypeptide binding]; other site 1205676000734 Walker A motif; other site 1205676000735 GTP binding site [chemical binding]; other site 1205676000736 Walker B motif; other site 1205676000737 cobyric acid synthase; Provisional; Region: PRK00784 1205676000738 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1205676000739 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1205676000740 catalytic triad [active] 1205676000741 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676000742 PPE family; Region: PPE; pfam00823 1205676000743 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1205676000744 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1205676000745 putative active site [active] 1205676000746 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1205676000747 putative active site [active] 1205676000748 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1205676000749 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1205676000750 active site 1205676000751 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1205676000752 DNA binding site [nucleotide binding] 1205676000753 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1205676000754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205676000755 Coenzyme A binding pocket [chemical binding]; other site 1205676000756 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1205676000757 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1205676000758 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1205676000759 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205676000760 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1205676000761 intersubunit interface [polypeptide binding]; other site 1205676000762 5-oxoprolinase; Region: PLN02666 1205676000763 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1205676000764 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1205676000765 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1205676000766 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1205676000767 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1205676000768 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1205676000769 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1205676000770 nucleotide binding site [chemical binding]; other site 1205676000771 acyl-CoA synthetase; Validated; Region: PRK07788 1205676000772 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676000773 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676000774 active site 1205676000775 CoA binding site [chemical binding]; other site 1205676000776 AMP binding site [chemical binding]; other site 1205676000777 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676000778 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676000779 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1205676000780 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676000781 FAD binding site [chemical binding]; other site 1205676000782 substrate binding site [chemical binding]; other site 1205676000783 catalytic base [active] 1205676000784 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205676000785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676000786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676000787 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1205676000788 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205676000789 Zn binding site [ion binding]; other site 1205676000790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1205676000791 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205676000792 putative active site [active] 1205676000793 PE family; Region: PE; pfam00934 1205676000794 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1205676000795 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205676000796 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676000797 PPE family; Region: PPE; pfam00823 1205676000798 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676000799 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205676000800 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205676000801 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1205676000802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676000803 Walker A motif; other site 1205676000804 ATP binding site [chemical binding]; other site 1205676000805 Walker B motif; other site 1205676000806 arginine finger; other site 1205676000807 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1205676000808 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1205676000809 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205676000810 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205676000811 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205676000812 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205676000813 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676000814 PPE family; Region: PPE; pfam00823 1205676000815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205676000816 EspG family; Region: ESX-1_EspG; pfam14011 1205676000817 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1205676000818 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205676000819 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1205676000820 active site 1205676000821 catalytic residues [active] 1205676000822 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1205676000823 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205676000824 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1205676000825 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1205676000826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676000827 S-adenosylmethionine binding site [chemical binding]; other site 1205676000828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424 1205676000829 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1205676000830 Sulfatase; Region: Sulfatase; cl17466 1205676000831 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676000832 PPE family; Region: PPE; pfam00823 1205676000833 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676000834 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676000835 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676000836 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676000837 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676000838 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676000839 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676000840 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676000841 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676000842 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676000843 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676000844 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1205676000845 putative FMN binding site [chemical binding]; other site 1205676000846 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1205676000847 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1205676000848 active site 1205676000849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1205676000850 SnoaL-like domain; Region: SnoaL_4; pfam13577 1205676000851 SnoaL-like domain; Region: SnoaL_3; pfam13474 1205676000852 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1205676000853 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205676000854 nucleotide binding site [chemical binding]; other site 1205676000855 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 1205676000856 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1205676000857 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1205676000858 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1205676000859 active site 1205676000860 catalytic residues [active] 1205676000861 Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829 1205676000862 Muconolactone delta-isomerase; Region: MIase; cl01992 1205676000863 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1205676000864 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1205676000865 putative active site [active] 1205676000866 catalytic site [active] 1205676000867 putative metal binding site [ion binding]; other site 1205676000868 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1205676000869 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1205676000870 putative substrate binding pocket [chemical binding]; other site 1205676000871 AC domain interface; other site 1205676000872 catalytic triad [active] 1205676000873 AB domain interface; other site 1205676000874 interchain disulfide; other site 1205676000875 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1205676000876 trimer interface [polypeptide binding]; other site 1205676000877 active site 1205676000878 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1205676000879 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205676000880 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1205676000881 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1205676000882 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 12775759 1205676000883 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 12775759 1205676000884 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205676000885 dimerization interface [polypeptide binding]; other site 1205676000886 putative DNA binding site [nucleotide binding]; other site 1205676000887 putative Zn2+ binding site [ion binding]; other site 1205676000888 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1205676000889 active site residue [active] 1205676000890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676000891 S-adenosylmethionine binding site [chemical binding]; other site 1205676000892 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676000893 Cytochrome P450; Region: p450; cl12078 1205676000894 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1205676000895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676000896 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1205676000897 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205676000898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676000899 S-adenosylmethionine binding site [chemical binding]; other site 1205676000900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676000901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676000902 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1205676000903 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205676000904 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1205676000905 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205676000906 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1205676000907 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1205676000908 substrate binding site; other site 1205676000909 tetramer interface; other site 1205676000910 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205676000911 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205676000912 active site 1205676000913 aminotransferase AlaT; Validated; Region: PRK09265 1205676000914 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205676000915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676000916 homodimer interface [polypeptide binding]; other site 1205676000917 catalytic residue [active] 1205676000918 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1205676000919 4Fe-4S binding domain; Region: Fer4; pfam00037 1205676000920 Cysteine-rich domain; Region: CCG; pfam02754 1205676000921 Cysteine-rich domain; Region: CCG; pfam02754 1205676000922 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205676000923 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205676000924 DNA binding residues [nucleotide binding] 1205676000925 dimerization interface [polypeptide binding]; other site 1205676000926 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1205676000927 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1205676000928 G1 box; other site 1205676000929 GTP/Mg2+ binding site [chemical binding]; other site 1205676000930 G2 box; other site 1205676000931 Switch I region; other site 1205676000932 G3 box; other site 1205676000933 Switch II region; other site 1205676000934 G4 box; other site 1205676000935 G5 box; other site 1205676000936 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 1205676000937 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1205676000938 G1 box; other site 1205676000939 GTP/Mg2+ binding site [chemical binding]; other site 1205676000940 G2 box; other site 1205676000941 Switch I region; other site 1205676000942 G3 box; other site 1205676000943 Switch II region; other site 1205676000944 Uncharacterized MobA-related protein [General function prediction only]; Region: COG2068 1205676000945 active site 1205676000946 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1205676000947 TIGR04255 family protein; Region: sporadTIGR04255 1205676000948 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1205676000949 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1205676000950 nucleotide binding site [chemical binding]; other site 1205676000951 NEF interaction site [polypeptide binding]; other site 1205676000952 SBD interface [polypeptide binding]; other site 1205676000953 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1205676000954 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1205676000955 dimer interface [polypeptide binding]; other site 1205676000956 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1205676000957 chaperone protein DnaJ; Provisional; Region: PRK14279 1205676000958 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1205676000959 HSP70 interaction site [polypeptide binding]; other site 1205676000960 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1205676000961 Zn binding sites [ion binding]; other site 1205676000962 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1205676000963 dimer interface [polypeptide binding]; other site 1205676000964 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1205676000965 DNA binding residues [nucleotide binding] 1205676000966 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205676000967 putative dimer interface [polypeptide binding]; other site 1205676000968 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676000969 PPE family; Region: PPE; pfam00823 1205676000970 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676000971 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676000972 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676000973 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676000974 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676000975 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676000976 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676000977 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1205676000978 CoenzymeA binding site [chemical binding]; other site 1205676000979 subunit interaction site [polypeptide binding]; other site 1205676000980 PHB binding site; other site 1205676000981 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1205676000982 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1205676000983 GDP-binding site [chemical binding]; other site 1205676000984 ACT binding site; other site 1205676000985 IMP binding site; other site 1205676000986 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1205676000987 Peptidase family M50; Region: Peptidase_M50; pfam02163 1205676000988 active site 1205676000989 putative substrate binding region [chemical binding]; other site 1205676000990 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1205676000991 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1205676000992 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1205676000993 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1205676000994 Divalent cation transporter; Region: MgtE; pfam01769 1205676000995 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1205676000996 fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; Region: FruBisAldo_II_A; TIGR01520 1205676000997 active site 1205676000998 intersubunit interface [polypeptide binding]; other site 1205676000999 zinc binding site [ion binding]; other site 1205676001000 Na+ binding site [ion binding]; other site 1205676001001 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1205676001002 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1205676001003 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 1205676001004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1205676001005 AAA domain; Region: AAA_33; pfam13671 1205676001006 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1205676001007 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1205676001008 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1205676001009 metal ion-dependent adhesion site (MIDAS); other site 1205676001010 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1205676001011 putative hydrophobic ligand binding site [chemical binding]; other site 1205676001012 MoxR-like ATPases [General function prediction only]; Region: COG0714 1205676001013 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1205676001014 Ligand binding site; other site 1205676001015 metal-binding site 1205676001016 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1205676001017 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1205676001018 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1205676001019 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1205676001020 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1205676001021 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1205676001022 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1205676001023 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205676001024 catalytic loop [active] 1205676001025 iron binding site [ion binding]; other site 1205676001026 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1205676001027 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1205676001028 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1205676001029 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1205676001030 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1205676001031 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1205676001032 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1205676001033 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205676001034 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205676001035 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1205676001036 dimerization interface [polypeptide binding]; other site 1205676001037 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205676001038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205676001039 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205676001040 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1205676001041 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1205676001042 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205676001043 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205676001044 active site 1205676001045 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1205676001046 Clp amino terminal domain; Region: Clp_N; pfam02861 1205676001047 Clp amino terminal domain; Region: Clp_N; pfam02861 1205676001048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676001049 Walker A motif; other site 1205676001050 ATP binding site [chemical binding]; other site 1205676001051 Walker B motif; other site 1205676001052 arginine finger; other site 1205676001053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676001054 Walker A motif; other site 1205676001055 ATP binding site [chemical binding]; other site 1205676001056 Walker B motif; other site 1205676001057 arginine finger; other site 1205676001058 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1205676001059 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1205676001060 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1205676001061 heme-binding site [chemical binding]; other site 1205676001062 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1205676001063 FAD binding pocket [chemical binding]; other site 1205676001064 FAD binding motif [chemical binding]; other site 1205676001065 phosphate binding motif [ion binding]; other site 1205676001066 beta-alpha-beta structure motif; other site 1205676001067 NAD binding pocket [chemical binding]; other site 1205676001068 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205676001069 cyclase homology domain; Region: CHD; cd07302 1205676001070 nucleotidyl binding site; other site 1205676001071 metal binding site [ion binding]; metal-binding site 1205676001072 dimer interface [polypeptide binding]; other site 1205676001073 Predicted ATPase [General function prediction only]; Region: COG3903 1205676001074 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1205676001075 Walker A motif; other site 1205676001076 ATP binding site [chemical binding]; other site 1205676001077 Walker B motif; other site 1205676001078 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205676001079 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205676001080 DNA binding residues [nucleotide binding] 1205676001081 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676001082 PPE family; Region: PPE; pfam00823 1205676001083 Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027 1205676001084 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1205676001085 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205676001086 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1205676001087 active site residue [active] 1205676001088 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1205676001089 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1205676001090 homodimer interface [polypeptide binding]; other site 1205676001091 substrate-cofactor binding pocket; other site 1205676001092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676001093 catalytic residue [active] 1205676001094 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1205676001095 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205676001096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205676001097 Evidence 4 : Homologs of previously reported genes of unknown function 1205676001098 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046 1205676001099 Evidence 4 : Homologs of previously reported genes of unknown function 1205676001100 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205676001101 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205676001102 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676001103 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676001104 active site 1205676001105 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1205676001106 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205676001107 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205676001108 acyl-CoA synthetase; Validated; Region: PRK05850 1205676001109 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205676001110 acyl-activating enzyme (AAE) consensus motif; other site 1205676001111 active site 1205676001112 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1205676001113 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676001114 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205676001115 active site 1205676001116 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205676001117 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205676001118 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676001119 Thioesterase; Region: PKS_TE; smart00824 1205676001120 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205676001121 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1205676001122 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1205676001123 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205676001124 phosphate acetyltransferase; Reviewed; Region: PRK05632 1205676001125 DRTGG domain; Region: DRTGG; pfam07085 1205676001126 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1205676001127 propionate/acetate kinase; Provisional; Region: PRK12379 1205676001128 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1205676001129 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205676001130 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205676001131 active site 1205676001132 ATP binding site [chemical binding]; other site 1205676001133 substrate binding site [chemical binding]; other site 1205676001134 activation loop (A-loop); other site 1205676001135 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1205676001136 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1205676001137 substrate binding pocket [chemical binding]; other site 1205676001138 membrane-bound complex binding site; other site 1205676001139 hinge residues; other site 1205676001140 NUDIX domain; Region: NUDIX; pfam00293 1205676001141 nudix motif; other site 1205676001142 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1205676001143 thiamine phosphate binding site [chemical binding]; other site 1205676001144 active site 1205676001145 pyrophosphate binding site [ion binding]; other site 1205676001146 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1205676001147 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1205676001148 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1205676001149 thiS-thiF/thiG interaction site; other site 1205676001150 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1205676001151 ThiS interaction site; other site 1205676001152 putative active site [active] 1205676001153 tetramer interface [polypeptide binding]; other site 1205676001154 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1205676001155 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1205676001156 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1205676001157 PA/protease or protease-like domain interface [polypeptide binding]; other site 1205676001158 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1205676001159 active site 1205676001160 metal binding site [ion binding]; metal-binding site 1205676001161 Predicted metalloprotease [General function prediction only]; Region: COG2321 1205676001162 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1205676001163 Zn binding site [ion binding]; other site 1205676001164 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1205676001165 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1205676001166 dimer interface [polypeptide binding]; other site 1205676001167 substrate binding site [chemical binding]; other site 1205676001168 ATP binding site [chemical binding]; other site 1205676001169 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1205676001170 ThiC-associated domain; Region: ThiC-associated; pfam13667 1205676001171 ThiC family; Region: ThiC; pfam01964 1205676001172 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205676001173 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1205676001174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205676001175 motif II; other site 1205676001176 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1205676001177 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1205676001178 putative catalytic site [active] 1205676001179 putative phosphate binding site [ion binding]; other site 1205676001180 active site 1205676001181 metal binding site A [ion binding]; metal-binding site 1205676001182 DNA binding site [nucleotide binding] 1205676001183 putative AP binding site [nucleotide binding]; other site 1205676001184 putative metal binding site B [ion binding]; other site 1205676001185 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1205676001186 active site 1205676001187 catalytic residues [active] 1205676001188 metal binding site [ion binding]; metal-binding site 1205676001189 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1205676001190 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205676001191 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1205676001192 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1205676001193 E-class dimer interface [polypeptide binding]; other site 1205676001194 P-class dimer interface [polypeptide binding]; other site 1205676001195 active site 1205676001196 Cu2+ binding site [ion binding]; other site 1205676001197 Zn2+ binding site [ion binding]; other site 1205676001198 carboxylate-amine ligase; Provisional; Region: PRK13517 1205676001199 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1205676001200 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1205676001201 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1205676001202 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1205676001203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676001204 Walker A motif; other site 1205676001205 ATP binding site [chemical binding]; other site 1205676001206 Walker B motif; other site 1205676001207 arginine finger; other site 1205676001208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676001209 Walker A motif; other site 1205676001210 ATP binding site [chemical binding]; other site 1205676001211 Walker B motif; other site 1205676001212 arginine finger; other site 1205676001213 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1205676001214 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1205676001215 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1205676001216 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1205676001217 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1205676001218 dimer interface [polypeptide binding]; other site 1205676001219 putative functional site; other site 1205676001220 putative MPT binding site; other site 1205676001221 short chain dehydrogenase; Provisional; Region: PRK06197 1205676001222 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1205676001223 putative NAD(P) binding site [chemical binding]; other site 1205676001224 active site 1205676001225 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1205676001226 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1205676001227 ring oligomerisation interface [polypeptide binding]; other site 1205676001228 ATP/Mg binding site [chemical binding]; other site 1205676001229 stacking interactions; other site 1205676001230 hinge regions; other site 1205676001231 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1205676001232 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676001233 PPE family; Region: PPE; pfam00823 1205676001234 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1205676001235 DinB superfamily; Region: DinB_2; pfam12867 1205676001236 putative anti-sigmaE protein; Provisional; Region: PRK13920 1205676001237 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1205676001238 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1205676001239 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205676001240 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205676001241 DNA binding residues [nucleotide binding] 1205676001242 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 1205676001243 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205676001244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676001245 S-adenosylmethionine binding site [chemical binding]; other site 1205676001246 Uncharacterized conserved protein [Function unknown]; Region: COG3496 1205676001247 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1205676001248 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 1205676001249 dimer interface [polypeptide binding]; other site 1205676001250 Transport protein; Region: actII; TIGR00833 1205676001251 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205676001252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676001253 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676001254 PPE family; Region: PPE; pfam00823 1205676001255 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676001256 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1205676001257 enoyl-CoA hydratase; Provisional; Region: PRK12478 1205676001258 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676001259 substrate binding site [chemical binding]; other site 1205676001260 oxyanion hole (OAH) forming residues; other site 1205676001261 trimer interface [polypeptide binding]; other site 1205676001262 PemK-like protein; Region: PemK; pfam02452 1205676001263 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1205676001264 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205676001265 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1205676001266 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1205676001267 NAD(P) binding site [chemical binding]; other site 1205676001268 catalytic residues [active] 1205676001269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 1205676001270 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1205676001271 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1205676001272 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205676001273 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205676001274 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1205676001275 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1205676001276 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205676001277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205676001278 non-specific DNA binding site [nucleotide binding]; other site 1205676001279 salt bridge; other site 1205676001280 sequence-specific DNA binding site [nucleotide binding]; other site 1205676001281 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1205676001282 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1205676001283 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1205676001284 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1205676001285 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1205676001286 active site 1205676001287 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205676001288 active site 2 [active] 1205676001289 isocitrate lyase; Provisional; Region: PRK15063 1205676001290 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556 1205676001291 oligomerization interface [polypeptide binding]; other site 1205676001292 active site 1205676001293 metal binding site [ion binding]; metal-binding site 1205676001294 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1205676001295 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205676001296 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1205676001297 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205676001298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676001299 S-adenosylmethionine binding site [chemical binding]; other site 1205676001300 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205676001301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205676001302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676001303 S-adenosylmethionine binding site [chemical binding]; other site 1205676001304 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1205676001305 UbiA prenyltransferase family; Region: UbiA; pfam01040 1205676001306 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12775759; Product type pe : putative enzyme 1205676001307 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12775759; Product type pe : putative enzyme 1205676001308 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676001309 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676001310 Predicted membrane protein [Function unknown]; Region: COG2733 1205676001311 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205676001312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205676001313 non-specific DNA binding site [nucleotide binding]; other site 1205676001314 salt bridge; other site 1205676001315 sequence-specific DNA binding site [nucleotide binding]; other site 1205676001316 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1205676001317 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1205676001318 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 1205676001319 catalytic residue [active] 1205676001320 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1205676001321 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1205676001322 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1205676001323 putative active site [active] 1205676001324 catalytic triad [active] 1205676001325 putative dimer interface [polypeptide binding]; other site 1205676001326 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1205676001327 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1205676001328 FAD binding domain; Region: FAD_binding_4; pfam01565 1205676001329 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1205676001330 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1205676001331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1205676001332 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1205676001333 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205676001334 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1205676001335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676001336 NAD(P) binding site [chemical binding]; other site 1205676001337 active site 1205676001338 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1205676001339 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205676001340 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1205676001341 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1205676001342 putative ADP-binding pocket [chemical binding]; other site 1205676001343 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1205676001344 L-lysine exporter; Region: 2a75; TIGR00948 1205676001345 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205676001346 catalytic core [active] 1205676001347 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1205676001348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205676001349 dimer interface [polypeptide binding]; other site 1205676001350 phosphorylation site [posttranslational modification] 1205676001351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205676001352 ATP binding site [chemical binding]; other site 1205676001353 Mg2+ binding site [ion binding]; other site 1205676001354 G-X-G motif; other site 1205676001355 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205676001356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205676001357 active site 1205676001358 phosphorylation site [posttranslational modification] 1205676001359 intermolecular recognition site; other site 1205676001360 dimerization interface [polypeptide binding]; other site 1205676001361 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205676001362 DNA binding site [nucleotide binding] 1205676001363 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1205676001364 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1205676001365 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205676001366 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205676001367 DNA-binding site [nucleotide binding]; DNA binding site 1205676001368 FCD domain; Region: FCD; pfam07729 1205676001369 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1205676001370 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1205676001371 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1205676001372 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1205676001373 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1205676001374 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1205676001375 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1205676001376 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1205676001377 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1205676001378 DNA binding domain, excisionase family; Region: excise; TIGR01764 1205676001379 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205676001380 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1205676001381 putative NAD(P) binding site [chemical binding]; other site 1205676001382 active site 1205676001383 putative substrate binding site [chemical binding]; other site 1205676001384 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205676001385 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1205676001386 putative acyl-acceptor binding pocket; other site 1205676001387 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205676001388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205676001389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676001390 S-adenosylmethionine binding site [chemical binding]; other site 1205676001391 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1205676001392 active site 1205676001393 catalytic site [active] 1205676001394 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1205676001395 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1205676001396 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205676001397 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205676001398 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1205676001399 glutamyl-tRNA reductase; Region: hemA; TIGR01035 1205676001400 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1205676001401 tRNA; other site 1205676001402 putative tRNA binding site [nucleotide binding]; other site 1205676001403 putative NADP binding site [chemical binding]; other site 1205676001404 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1205676001405 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1205676001406 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1205676001407 domain interfaces; other site 1205676001408 active site 1205676001409 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1205676001410 active site 1205676001411 homodimer interface [polypeptide binding]; other site 1205676001412 SAM binding site [chemical binding]; other site 1205676001413 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1205676001414 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1205676001415 active site 1205676001416 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1205676001417 dimer interface [polypeptide binding]; other site 1205676001418 active site 1205676001419 Schiff base residues; other site 1205676001420 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205676001421 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205676001422 active site 1205676001423 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205676001424 anti sigma factor interaction site; other site 1205676001425 regulatory phosphorylation site [posttranslational modification]; other site 1205676001426 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1205676001427 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1205676001428 active site 1205676001429 catalytic triad [active] 1205676001430 oxyanion hole [active] 1205676001431 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1205676001432 PE family; Region: PE; pfam00934 1205676001433 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205676001434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676001435 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1205676001436 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205676001437 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1205676001438 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205676001439 inhibitor-cofactor binding pocket; inhibition site 1205676001440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676001441 catalytic residue [active] 1205676001442 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205676001443 catalytic core [active] 1205676001444 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1205676001445 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205676001446 catalytic residues [active] 1205676001447 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1205676001448 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1205676001449 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1205676001450 ResB-like family; Region: ResB; pfam05140 1205676001451 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1205676001452 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205676001453 AAA domain; Region: AAA_31; pfam13614 1205676001454 P-loop; other site 1205676001455 Magnesium ion binding site [ion binding]; other site 1205676001456 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1205676001457 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 1205676001458 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1205676001459 dimer interface [polypeptide binding]; other site 1205676001460 active site 1205676001461 CoA binding pocket [chemical binding]; other site 1205676001462 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1205676001463 UbiA prenyltransferase family; Region: UbiA; pfam01040 1205676001464 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1205676001465 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205676001466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676001467 NAD(P) binding site [chemical binding]; other site 1205676001468 active site 1205676001469 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1205676001470 Ligand binding site; other site 1205676001471 Putative Catalytic site; other site 1205676001472 DXD motif; other site 1205676001473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222 1205676001474 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1205676001475 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676001476 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676001477 acyl-activating enzyme (AAE) consensus motif; other site 1205676001478 acyl-activating enzyme (AAE) consensus motif; other site 1205676001479 AMP binding site [chemical binding]; other site 1205676001480 active site 1205676001481 CoA binding site [chemical binding]; other site 1205676001482 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1205676001483 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1205676001484 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1205676001485 active site 1205676001486 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205676001487 short chain dehydrogenase; Provisional; Region: PRK05866 1205676001488 classical (c) SDRs; Region: SDR_c; cd05233 1205676001489 NAD(P) binding site [chemical binding]; other site 1205676001490 active site 1205676001491 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676001492 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1205676001493 substrate binding site [chemical binding]; other site 1205676001494 oxyanion hole (OAH) forming residues; other site 1205676001495 trimer interface [polypeptide binding]; other site 1205676001496 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1205676001497 putative active site [active] 1205676001498 homotetrameric interface [polypeptide binding]; other site 1205676001499 metal binding site [ion binding]; metal-binding site 1205676001500 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302 1205676001501 acyl-CoA synthetase; Validated; Region: PRK06188 1205676001502 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1205676001503 putative active site [active] 1205676001504 putative CoA binding site [chemical binding]; other site 1205676001505 putative AMP binding site [chemical binding]; other site 1205676001506 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1205676001507 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1205676001508 active site 1205676001509 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1205676001510 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1205676001511 active site 1205676001512 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676001513 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1205676001514 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205676001515 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1205676001516 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1205676001517 dimer interface [polypeptide binding]; other site 1205676001518 tetramer interface [polypeptide binding]; other site 1205676001519 PYR/PP interface [polypeptide binding]; other site 1205676001520 TPP binding site [chemical binding]; other site 1205676001521 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1205676001522 TPP-binding site; other site 1205676001523 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1205676001524 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205676001525 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1205676001526 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1205676001527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676001528 S-adenosylmethionine binding site [chemical binding]; other site 1205676001529 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205676001530 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205676001531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676001532 S-adenosylmethionine binding site [chemical binding]; other site 1205676001533 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1205676001534 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205676001535 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205676001536 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205676001537 substrate binding pocket [chemical binding]; other site 1205676001538 chain length determination region; other site 1205676001539 substrate-Mg2+ binding site; other site 1205676001540 catalytic residues [active] 1205676001541 aspartate-rich region 1; other site 1205676001542 active site lid residues [active] 1205676001543 aspartate-rich region 2; other site 1205676001544 heat shock protein HtpX; Provisional; Region: PRK03072 1205676001545 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1205676001546 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1205676001547 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1205676001548 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205676001549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205676001550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1205676001551 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1205676001552 O-methyltransferase; Region: Methyltransf_2; pfam00891 1205676001553 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676001554 Cytochrome P450; Region: p450; cl12078 1205676001555 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1205676001556 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12694625, 12775759, 15024109, 15525680; Product type pe : putative enzyme 1205676001557 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12694625, 12775759, 15024109, 15525680; Product type pe : putative enzyme 1205676001558 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205676001559 active site 1205676001560 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205676001561 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1205676001562 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 1205676001563 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1205676001564 active site 1205676001565 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1205676001566 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1205676001567 putative active site [active] 1205676001568 putative metal binding site [ion binding]; other site 1205676001569 hypothetical protein; Provisional; Region: PRK07588 1205676001570 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205676001571 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205676001572 dimerization interface [polypeptide binding]; other site 1205676001573 putative DNA binding site [nucleotide binding]; other site 1205676001574 putative Zn2+ binding site [ion binding]; other site 1205676001575 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1205676001576 putative hydrophobic ligand binding site [chemical binding]; other site 1205676001577 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205676001578 TIGR03086 family protein; Region: TIGR03086 1205676001579 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205676001580 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205676001581 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1205676001582 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1205676001583 Protein of unknown function DUF82; Region: DUF82; pfam01927 1205676001584 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205676001585 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205676001586 putative active site [active] 1205676001587 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1205676001588 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1205676001589 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1205676001590 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1205676001591 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205676001592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205676001593 DNA-binding site [nucleotide binding]; DNA binding site 1205676001594 FCD domain; Region: FCD; pfam07729 1205676001595 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205676001596 Permease; Region: Permease; pfam02405 1205676001597 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205676001598 Permease; Region: Permease; pfam02405 1205676001599 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676001600 mce related protein; Region: MCE; pfam02470 1205676001601 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205676001602 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1205676001603 mce related protein; Region: MCE; pfam02470 1205676001604 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205676001605 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676001606 mce related protein; Region: MCE; pfam02470 1205676001607 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676001608 mce related protein; Region: MCE; pfam02470 1205676001609 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205676001610 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676001611 mce related protein; Region: MCE; pfam02470 1205676001612 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676001613 mce related protein; Region: MCE; pfam02470 1205676001614 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1205676001615 oligomeric interface; other site 1205676001616 putative active site [active] 1205676001617 homodimer interface [polypeptide binding]; other site 1205676001618 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205676001619 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1205676001620 AAA domain; Region: AAA_14; pfam13173 1205676001621 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1205676001622 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1205676001623 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pr : putative regulator 1205676001624 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pr : putative regulator 1205676001625 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1205676001626 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1205676001627 putative active site [active] 1205676001628 SEC-C motif; Region: SEC-C; pfam02810 1205676001629 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 1205676001630 putative active site [active] 1205676001631 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1205676001632 dimer interface [polypeptide binding]; other site 1205676001633 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1205676001634 active site 1205676001635 galactokinase; Provisional; Region: PRK00555 1205676001636 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1205676001637 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205676001638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1205676001639 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1205676001640 putative active site [active] 1205676001641 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1205676001642 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1205676001643 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205676001644 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1205676001645 oligomeric interface; other site 1205676001646 putative active site [active] 1205676001647 homodimer interface [polypeptide binding]; other site 1205676001648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 1205676001649 FIST N domain; Region: FIST; pfam08495 1205676001650 FIST C domain; Region: FIST_C; pfam10442 1205676001651 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1205676001652 AAA domain; Region: AAA_30; pfam13604 1205676001653 Family description; Region: UvrD_C_2; pfam13538 1205676001654 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1205676001655 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1205676001656 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1205676001657 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1205676001658 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205676001659 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676001660 substrate binding site [chemical binding]; other site 1205676001661 oxyanion hole (OAH) forming residues; other site 1205676001662 trimer interface [polypeptide binding]; other site 1205676001663 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1205676001664 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205676001665 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1205676001666 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1205676001667 active site 1205676001668 catalytic site [active] 1205676001669 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1205676001670 active site 1205676001671 catalytic site [active] 1205676001672 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1205676001673 active site 1205676001674 catalytic site [active] 1205676001675 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1205676001676 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1205676001677 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1205676001678 putative homodimer interface [polypeptide binding]; other site 1205676001679 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1205676001680 heterodimer interface [polypeptide binding]; other site 1205676001681 homodimer interface [polypeptide binding]; other site 1205676001682 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1205676001683 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1205676001684 23S rRNA interface [nucleotide binding]; other site 1205676001685 L7/L12 interface [polypeptide binding]; other site 1205676001686 putative thiostrepton binding site; other site 1205676001687 L25 interface [polypeptide binding]; other site 1205676001688 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1205676001689 mRNA/rRNA interface [nucleotide binding]; other site 1205676001690 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205676001691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676001692 S-adenosylmethionine binding site [chemical binding]; other site 1205676001693 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205676001694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205676001695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676001696 S-adenosylmethionine binding site [chemical binding]; other site 1205676001697 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205676001698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205676001699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676001700 S-adenosylmethionine binding site [chemical binding]; other site 1205676001701 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205676001702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205676001703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676001704 S-adenosylmethionine binding site [chemical binding]; other site 1205676001705 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676001706 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205676001707 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1205676001708 ABC1 family; Region: ABC1; cl17513 1205676001709 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1205676001710 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1205676001711 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1205676001712 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1205676001713 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1205676001714 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205676001715 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1205676001716 23S rRNA interface [nucleotide binding]; other site 1205676001717 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1205676001718 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1205676001719 core dimer interface [polypeptide binding]; other site 1205676001720 peripheral dimer interface [polypeptide binding]; other site 1205676001721 L10 interface [polypeptide binding]; other site 1205676001722 L11 interface [polypeptide binding]; other site 1205676001723 putative EF-Tu interaction site [polypeptide binding]; other site 1205676001724 putative EF-G interaction site [polypeptide binding]; other site 1205676001725 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676001726 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676001727 WHG domain; Region: WHG; pfam13305 1205676001728 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1205676001729 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1205676001730 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1205676001731 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1205676001732 Walker A/P-loop; other site 1205676001733 ATP binding site [chemical binding]; other site 1205676001734 Q-loop/lid; other site 1205676001735 ABC transporter signature motif; other site 1205676001736 Walker B; other site 1205676001737 D-loop; other site 1205676001738 H-loop/switch region; other site 1205676001739 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1205676001740 putative active site [active] 1205676001741 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205676001742 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 1205676001743 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205676001744 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 1205676001745 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1205676001746 Sulfatase; Region: Sulfatase; pfam00884 1205676001747 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1205676001748 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1205676001749 putative active site [active] 1205676001750 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1205676001751 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1205676001752 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1205676001753 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1205676001754 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1205676001755 RPB10 interaction site [polypeptide binding]; other site 1205676001756 RPB1 interaction site [polypeptide binding]; other site 1205676001757 RPB11 interaction site [polypeptide binding]; other site 1205676001758 RPB3 interaction site [polypeptide binding]; other site 1205676001759 RPB12 interaction site [polypeptide binding]; other site 1205676001760 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1205676001761 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1205676001762 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1205676001763 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1205676001764 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1205676001765 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1205676001766 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1205676001767 G-loop; other site 1205676001768 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1205676001769 DNA binding site [nucleotide binding] 1205676001770 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1205676001771 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1205676001772 endonuclease IV; Provisional; Region: PRK01060 1205676001773 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1205676001774 AP (apurinic/apyrimidinic) site pocket; other site 1205676001775 DNA interaction; other site 1205676001776 Metal-binding active site; metal-binding site 1205676001777 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1205676001778 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1205676001779 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1205676001780 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676001781 active site 1205676001782 enoyl-CoA hydratase; Provisional; Region: PRK12478 1205676001783 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676001784 substrate binding site [chemical binding]; other site 1205676001785 oxyanion hole (OAH) forming residues; other site 1205676001786 trimer interface [polypeptide binding]; other site 1205676001787 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 1205676001788 PaaX-like protein; Region: PaaX; pfam07848 1205676001789 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1205676001790 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205676001791 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676001792 substrate binding site [chemical binding]; other site 1205676001793 oxyanion hole (OAH) forming residues; other site 1205676001794 trimer interface [polypeptide binding]; other site 1205676001795 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205676001796 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205676001797 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1205676001798 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1205676001799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676001800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676001801 WHG domain; Region: WHG; pfam13305 1205676001802 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1205676001803 S17 interaction site [polypeptide binding]; other site 1205676001804 S8 interaction site; other site 1205676001805 16S rRNA interaction site [nucleotide binding]; other site 1205676001806 streptomycin interaction site [chemical binding]; other site 1205676001807 23S rRNA interaction site [nucleotide binding]; other site 1205676001808 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1205676001809 30S ribosomal protein S7; Validated; Region: PRK05302 1205676001810 elongation factor G; Reviewed; Region: PRK00007 1205676001811 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1205676001812 G1 box; other site 1205676001813 putative GEF interaction site [polypeptide binding]; other site 1205676001814 GTP/Mg2+ binding site [chemical binding]; other site 1205676001815 Switch I region; other site 1205676001816 G2 box; other site 1205676001817 G3 box; other site 1205676001818 Switch II region; other site 1205676001819 G4 box; other site 1205676001820 G5 box; other site 1205676001821 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1205676001822 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1205676001823 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1205676001824 elongation factor Tu; Reviewed; Region: PRK00049 1205676001825 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1205676001826 G1 box; other site 1205676001827 GEF interaction site [polypeptide binding]; other site 1205676001828 GTP/Mg2+ binding site [chemical binding]; other site 1205676001829 Switch I region; other site 1205676001830 G2 box; other site 1205676001831 G3 box; other site 1205676001832 Switch II region; other site 1205676001833 G4 box; other site 1205676001834 G5 box; other site 1205676001835 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1205676001836 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1205676001837 Antibiotic Binding Site [chemical binding]; other site 1205676001838 Short C-terminal domain; Region: SHOCT; pfam09851 1205676001839 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1205676001840 classical (c) SDRs; Region: SDR_c; cd05233 1205676001841 NAD(P) binding site [chemical binding]; other site 1205676001842 active site 1205676001843 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1205676001844 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205676001845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427 1205676001846 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1205676001847 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676001848 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1205676001849 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1205676001850 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205676001851 FeS/SAM binding site; other site 1205676001852 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1205676001853 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1205676001854 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205676001855 phosphate binding site [ion binding]; other site 1205676001856 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1205676001857 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1205676001858 catalytic residues [active] 1205676001859 catalytic nucleophile [active] 1205676001860 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1205676001861 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205676001862 Probable transposase; Region: OrfB_IS605; pfam01385 1205676001863 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1205676001864 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1205676001865 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205676001866 active site 1205676001867 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205676001868 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1205676001869 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1205676001870 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1205676001871 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1205676001872 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1205676001873 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1205676001874 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1205676001875 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1205676001876 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1205676001877 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1205676001878 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1205676001879 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1205676001880 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1205676001881 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1205676001882 putative translocon binding site; other site 1205676001883 protein-rRNA interface [nucleotide binding]; other site 1205676001884 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1205676001885 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1205676001886 G-X-X-G motif; other site 1205676001887 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1205676001888 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1205676001889 23S rRNA interface [nucleotide binding]; other site 1205676001890 5S rRNA interface [nucleotide binding]; other site 1205676001891 putative antibiotic binding site [chemical binding]; other site 1205676001892 L25 interface [polypeptide binding]; other site 1205676001893 L27 interface [polypeptide binding]; other site 1205676001894 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1205676001895 putative translocon interaction site; other site 1205676001896 23S rRNA interface [nucleotide binding]; other site 1205676001897 signal recognition particle (SRP54) interaction site; other site 1205676001898 L23 interface [polypeptide binding]; other site 1205676001899 trigger factor interaction site; other site 1205676001900 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1205676001901 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1205676001902 Sulfatase; Region: Sulfatase; pfam00884 1205676001903 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 1205676001904 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1205676001905 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1205676001906 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1205676001907 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1205676001908 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1205676001909 RNA binding site [nucleotide binding]; other site 1205676001910 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1205676001911 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1205676001912 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1205676001913 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1205676001914 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1205676001915 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1205676001916 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1205676001917 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1205676001918 5S rRNA interface [nucleotide binding]; other site 1205676001919 23S rRNA interface [nucleotide binding]; other site 1205676001920 L5 interface [polypeptide binding]; other site 1205676001921 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1205676001922 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1205676001923 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1205676001924 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1205676001925 23S rRNA binding site [nucleotide binding]; other site 1205676001926 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1205676001927 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1205676001928 tandem repeat interface [polypeptide binding]; other site 1205676001929 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1205676001930 oligomer interface [polypeptide binding]; other site 1205676001931 active site residues [active] 1205676001932 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1205676001933 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1205676001934 tandem repeat interface [polypeptide binding]; other site 1205676001935 oligomer interface [polypeptide binding]; other site 1205676001936 active site residues [active] 1205676001937 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1205676001938 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205676001939 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205676001940 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205676001941 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205676001942 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1205676001943 intersubunit interface [polypeptide binding]; other site 1205676001944 active site 1205676001945 Zn2+ binding site [ion binding]; other site 1205676001946 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1205676001947 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1205676001948 NAD binding site [chemical binding]; other site 1205676001949 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1205676001950 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205676001951 nucleotide binding site [chemical binding]; other site 1205676001952 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1205676001953 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205676001954 Coenzyme A binding pocket [chemical binding]; other site 1205676001955 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205676001956 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205676001957 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1205676001958 SecY translocase; Region: SecY; pfam00344 1205676001959 adenylate kinase; Reviewed; Region: adk; PRK00279 1205676001960 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1205676001961 AMP-binding site [chemical binding]; other site 1205676001962 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1205676001963 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1205676001964 active site 1205676001965 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1205676001966 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205676001967 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205676001968 DNA binding residues [nucleotide binding] 1205676001969 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1205676001970 Putative zinc-finger; Region: zf-HC2; pfam13490 1205676001971 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205676001972 MarR family; Region: MarR; pfam01047 1205676001973 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205676001974 TIGR03086 family protein; Region: TIGR03086 1205676001975 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1205676001976 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1205676001977 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1205676001978 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676001979 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676001980 active site 1205676001981 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1205676001982 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1205676001983 tetrameric interface [polypeptide binding]; other site 1205676001984 NAD binding site [chemical binding]; other site 1205676001985 catalytic residues [active] 1205676001986 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205676001987 catalytic core [active] 1205676001988 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676001989 PPE family; Region: PPE; pfam00823 1205676001990 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676001991 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205676001992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205676001993 active site 1205676001994 phosphorylation site [posttranslational modification] 1205676001995 intermolecular recognition site; other site 1205676001996 dimerization interface [polypeptide binding]; other site 1205676001997 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205676001998 DNA binding site [nucleotide binding] 1205676001999 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205676002000 dimerization interface [polypeptide binding]; other site 1205676002001 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205676002002 dimer interface [polypeptide binding]; other site 1205676002003 phosphorylation site [posttranslational modification] 1205676002004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205676002005 ATP binding site [chemical binding]; other site 1205676002006 Mg2+ binding site [ion binding]; other site 1205676002007 G-X-G motif; other site 1205676002008 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1205676002009 nucleotide binding site/active site [active] 1205676002010 HIT family signature motif; other site 1205676002011 catalytic residue [active] 1205676002012 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1205676002013 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1205676002014 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1205676002015 NAD binding site [chemical binding]; other site 1205676002016 catalytic Zn binding site [ion binding]; other site 1205676002017 substrate binding site [chemical binding]; other site 1205676002018 structural Zn binding site [ion binding]; other site 1205676002019 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1205676002020 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1205676002021 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1205676002022 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676002023 Cytochrome P450; Region: p450; cl12078 1205676002024 short chain dehydrogenase; Provisional; Region: PRK07775 1205676002025 classical (c) SDRs; Region: SDR_c; cd05233 1205676002026 NAD(P) binding site [chemical binding]; other site 1205676002027 active site 1205676002028 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676002029 Cytochrome P450; Region: p450; cl12078 1205676002030 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676002031 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1205676002032 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1205676002033 NAD binding site [chemical binding]; other site 1205676002034 catalytic residues [active] 1205676002035 short chain dehydrogenase; Provisional; Region: PRK07774 1205676002036 classical (c) SDRs; Region: SDR_c; cd05233 1205676002037 NAD(P) binding site [chemical binding]; other site 1205676002038 active site 1205676002039 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205676002040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205676002041 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205676002042 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1205676002043 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1205676002044 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1205676002045 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1205676002046 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1205676002047 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1205676002048 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1205676002049 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1205676002050 Predicted esterase [General function prediction only]; Region: COG0627 1205676002051 S-formylglutathione hydrolase; Region: PLN02442 1205676002052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1205676002053 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1205676002054 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 1205676002055 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1205676002056 tetramer interface [polypeptide binding]; other site 1205676002057 active site 1205676002058 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676002059 Cytochrome P450; Region: p450; cl12078 1205676002060 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1205676002061 ATP binding site [chemical binding]; other site 1205676002062 active site 1205676002063 substrate binding site [chemical binding]; other site 1205676002064 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1205676002065 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205676002066 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205676002067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676002068 putative substrate translocation pore; other site 1205676002069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676002070 Predicted deacetylase [General function prediction only]; Region: COG3233 1205676002071 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1205676002072 putative active site [active] 1205676002073 putative Zn binding site [ion binding]; other site 1205676002074 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1205676002075 FAD binding domain; Region: FAD_binding_2; pfam00890 1205676002076 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1205676002077 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1205676002078 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1205676002079 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1205676002080 putative active site [active] 1205676002081 catalytic triad [active] 1205676002082 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205676002083 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1205676002084 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205676002085 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1205676002086 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1205676002087 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205676002088 DNA-binding site [nucleotide binding]; DNA binding site 1205676002089 UTRA domain; Region: UTRA; pfam07702 1205676002090 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1205676002091 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1205676002092 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1205676002093 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205676002094 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205676002095 Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659 1205676002096 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1205676002097 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1205676002098 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1205676002099 active site 1205676002100 metal binding site [ion binding]; metal-binding site 1205676002101 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1205676002102 active site 1205676002103 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1205676002104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205676002105 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1205676002106 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1205676002107 dimerization interface [polypeptide binding]; other site 1205676002108 ATP binding site [chemical binding]; other site 1205676002109 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1205676002110 dimerization interface [polypeptide binding]; other site 1205676002111 ATP binding site [chemical binding]; other site 1205676002112 CAAX protease self-immunity; Region: Abi; pfam02517 1205676002113 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1205676002114 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1205676002115 active site 1205676002116 metal binding site [ion binding]; metal-binding site 1205676002117 hexamer interface [polypeptide binding]; other site 1205676002118 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1205676002119 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1205676002120 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1205676002121 active site 1205676002122 tetramer interface [polypeptide binding]; other site 1205676002123 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205676002124 active site 1205676002125 phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878 1205676002126 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1205676002127 dimerization interface [polypeptide binding]; other site 1205676002128 putative ATP binding site [chemical binding]; other site 1205676002129 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1205676002130 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1205676002131 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1205676002132 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1205676002133 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1205676002134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676002135 catalytic residue [active] 1205676002136 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1205676002137 heme-binding site [chemical binding]; other site 1205676002138 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1205676002139 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1205676002140 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1205676002141 active site residue [active] 1205676002142 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1205676002143 active site residue [active] 1205676002144 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1205676002145 catalytic residues [active] 1205676002146 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1205676002147 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205676002148 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205676002149 DNA binding site [nucleotide binding] 1205676002150 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1205676002151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205676002152 Coenzyme A binding pocket [chemical binding]; other site 1205676002153 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1205676002154 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1205676002155 Walker A/P-loop; other site 1205676002156 ATP binding site [chemical binding]; other site 1205676002157 Q-loop/lid; other site 1205676002158 ABC transporter signature motif; other site 1205676002159 Walker B; other site 1205676002160 D-loop; other site 1205676002161 H-loop/switch region; other site 1205676002162 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1205676002163 PhoU domain; Region: PhoU; pfam01895 1205676002164 PhoU domain; Region: PhoU; pfam01895 1205676002165 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1205676002166 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205676002167 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1205676002168 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1205676002169 FMN binding site [chemical binding]; other site 1205676002170 active site 1205676002171 catalytic residues [active] 1205676002172 substrate binding site [chemical binding]; other site 1205676002173 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1205676002174 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1205676002175 homodimer interface [polypeptide binding]; other site 1205676002176 putative substrate binding pocket [chemical binding]; other site 1205676002177 diiron center [ion binding]; other site 1205676002178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676002179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1205676002180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205676002181 dimerization interface [polypeptide binding]; other site 1205676002182 putative DNA binding site [nucleotide binding]; other site 1205676002183 putative Zn2+ binding site [ion binding]; other site 1205676002184 Cytosine/adenosine deaminases [Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis]; Region: CumB; COG0590 1205676002185 active site 1205676002186 Zn binding site [ion binding]; other site 1205676002187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205676002188 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205676002189 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205676002190 TIGR04255 family protein; Region: sporadTIGR04255 1205676002191 PE family; Region: PE; pfam00934 1205676002192 Evidence 2b : Function of strongly homologous gene; Product type rc : receptor 1205676002193 PE family; Region: PE; pfam00934 1205676002194 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205676002195 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 1205676002196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 1205676002197 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 1205676002198 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1205676002199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676002200 S-adenosylmethionine binding site [chemical binding]; other site 1205676002201 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1205676002202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676002203 putative substrate translocation pore; other site 1205676002204 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205676002205 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1205676002206 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1205676002207 tetramer interface [polypeptide binding]; other site 1205676002208 TPP-binding site [chemical binding]; other site 1205676002209 heterodimer interface [polypeptide binding]; other site 1205676002210 phosphorylation loop region [posttranslational modification] 1205676002211 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205676002212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205676002213 active site 1205676002214 phosphorylation site [posttranslational modification] 1205676002215 intermolecular recognition site; other site 1205676002216 dimerization interface [polypeptide binding]; other site 1205676002217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205676002218 DNA binding residues [nucleotide binding] 1205676002219 dimerization interface [polypeptide binding]; other site 1205676002220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205676002221 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1205676002222 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1205676002223 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1205676002224 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1205676002225 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1205676002226 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1205676002227 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1205676002228 dimer interface [polypeptide binding]; other site 1205676002229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676002230 catalytic residue [active] 1205676002231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676002232 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1205676002233 putative substrate translocation pore; other site 1205676002234 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1205676002235 short chain dehydrogenase; Provisional; Region: PRK05876 1205676002236 classical (c) SDRs; Region: SDR_c; cd05233 1205676002237 NAD(P) binding site [chemical binding]; other site 1205676002238 active site 1205676002239 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676002240 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1205676002241 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1205676002242 dimer interface [polypeptide binding]; other site 1205676002243 PYR/PP interface [polypeptide binding]; other site 1205676002244 TPP binding site [chemical binding]; other site 1205676002245 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205676002246 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1205676002247 TPP-binding site [chemical binding]; other site 1205676002248 dimer interface [polypeptide binding]; other site 1205676002249 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1205676002250 putative hydrophobic ligand binding site [chemical binding]; other site 1205676002251 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205676002252 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205676002253 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1205676002254 putative hydrophobic ligand binding site [chemical binding]; other site 1205676002255 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1205676002256 putative hydrophobic ligand binding site [chemical binding]; other site 1205676002257 aminotransferase; Validated; Region: PRK07777 1205676002258 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205676002259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676002260 homodimer interface [polypeptide binding]; other site 1205676002261 catalytic residue [active] 1205676002262 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1205676002263 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205676002264 dimer interface [polypeptide binding]; other site 1205676002265 active site 1205676002266 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1205676002267 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676002268 substrate binding site [chemical binding]; other site 1205676002269 oxyanion hole (OAH) forming residues; other site 1205676002270 trimer interface [polypeptide binding]; other site 1205676002271 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205676002272 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1205676002273 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1205676002274 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1205676002275 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1205676002276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205676002277 ATP binding site [chemical binding]; other site 1205676002278 putative Mg++ binding site [ion binding]; other site 1205676002279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205676002280 nucleotide binding region [chemical binding]; other site 1205676002281 ATP-binding site [chemical binding]; other site 1205676002282 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1205676002283 WYL domain; Region: WYL; pfam13280 1205676002284 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1205676002285 trimer interface [polypeptide binding]; other site 1205676002286 dimer interface [polypeptide binding]; other site 1205676002287 putative active site [active] 1205676002288 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1205676002289 MPT binding site; other site 1205676002290 trimer interface [polypeptide binding]; other site 1205676002291 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1205676002292 MoaE homodimer interface [polypeptide binding]; other site 1205676002293 MoaD interaction [polypeptide binding]; other site 1205676002294 active site residues [active] 1205676002295 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1205676002296 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1205676002297 MoaE interaction surface [polypeptide binding]; other site 1205676002298 MoeB interaction surface [polypeptide binding]; other site 1205676002299 thiocarboxylated glycine; other site 1205676002300 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1205676002301 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205676002302 FeS/SAM binding site; other site 1205676002303 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1205676002304 hypothetical protein; Provisional; Region: PRK11770 1205676002305 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1205676002306 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1205676002307 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1205676002308 DNA-binding site [nucleotide binding]; DNA binding site 1205676002309 RNA-binding motif; other site 1205676002310 PE family; Region: PE; pfam00934 1205676002311 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676002312 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676002313 active site 1205676002314 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1205676002315 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205676002316 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1205676002317 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676002318 PPE family; Region: PPE; pfam00823 1205676002319 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676002320 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 1205676002321 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205676002322 MarR family; Region: MarR; pfam01047 1205676002323 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1205676002324 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1205676002325 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205676002326 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1205676002327 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1205676002328 phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366 1205676002329 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205676002330 catalytic residue [active] 1205676002331 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1205676002332 Ferredoxin [Energy production and conversion]; Region: COG1146 1205676002333 4Fe-4S binding domain; Region: Fer4; pfam00037 1205676002334 ferredoxin-NADP+ reductase; Region: PLN02852 1205676002335 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205676002336 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1205676002337 putative dimer interface [polypeptide binding]; other site 1205676002338 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205676002339 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1205676002340 putative catalytic site [active] 1205676002341 putative phosphate binding site [ion binding]; other site 1205676002342 putative metal binding site [ion binding]; other site 1205676002343 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1205676002344 dimer interface [polypeptide binding]; other site 1205676002345 Citrate synthase; Region: Citrate_synt; pfam00285 1205676002346 active site 1205676002347 citrylCoA binding site [chemical binding]; other site 1205676002348 oxalacetate/citrate binding site [chemical binding]; other site 1205676002349 coenzyme A binding site [chemical binding]; other site 1205676002350 catalytic triad [active] 1205676002351 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205676002352 cyclase homology domain; Region: CHD; cd07302 1205676002353 nucleotidyl binding site; other site 1205676002354 metal binding site [ion binding]; metal-binding site 1205676002355 dimer interface [polypeptide binding]; other site 1205676002356 AAA ATPase domain; Region: AAA_16; pfam13191 1205676002357 Predicted ATPase [General function prediction only]; Region: COG3903 1205676002358 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205676002359 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205676002360 DNA binding residues [nucleotide binding] 1205676002361 dimerization interface [polypeptide binding]; other site 1205676002362 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205676002363 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205676002364 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205676002365 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205676002366 AAA ATPase domain; Region: AAA_16; pfam13191 1205676002367 Predicted ATPase [General function prediction only]; Region: COG3903 1205676002368 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205676002369 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205676002370 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1205676002371 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1205676002372 dimer interface [polypeptide binding]; other site 1205676002373 active site 1205676002374 citrylCoA binding site [chemical binding]; other site 1205676002375 NADH binding [chemical binding]; other site 1205676002376 cationic pore residues; other site 1205676002377 oxalacetate/citrate binding site [chemical binding]; other site 1205676002378 coenzyme A binding site [chemical binding]; other site 1205676002379 catalytic triad [active] 1205676002380 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1205676002381 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205676002382 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1205676002383 BON domain; Region: BON; pfam04972 1205676002384 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1205676002385 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1205676002386 ligand binding site [chemical binding]; other site 1205676002387 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205676002388 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205676002389 dimerization interface [polypeptide binding]; other site 1205676002390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205676002391 dimer interface [polypeptide binding]; other site 1205676002392 phosphorylation site [posttranslational modification] 1205676002393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205676002394 Mg2+ binding site [ion binding]; other site 1205676002395 G-X-G motif; other site 1205676002396 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205676002397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205676002398 active site 1205676002399 phosphorylation site [posttranslational modification] 1205676002400 intermolecular recognition site; other site 1205676002401 dimerization interface [polypeptide binding]; other site 1205676002402 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205676002403 DNA binding site [nucleotide binding] 1205676002404 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1205676002405 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825 1205676002406 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205676002407 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676002408 substrate binding site [chemical binding]; other site 1205676002409 oxyanion hole (OAH) forming residues; other site 1205676002410 trimer interface [polypeptide binding]; other site 1205676002411 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1205676002412 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1205676002413 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205676002414 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205676002415 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1205676002416 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1205676002417 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205676002418 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205676002419 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1205676002420 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1205676002421 hydrophobic ligand binding site; other site 1205676002422 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205676002423 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205676002424 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1205676002425 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205676002426 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1205676002427 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1205676002428 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 1205676002429 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205676002430 active site 1205676002431 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676002432 PPE family; Region: PPE; pfam00823 1205676002433 PE family; Region: PE; pfam00934 1205676002434 BCCT family transporter; Region: BCCT; pfam02028 1205676002435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1205676002436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205676002437 Coenzyme A binding pocket [chemical binding]; other site 1205676002438 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1205676002439 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205676002440 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1205676002441 MULE transposase domain; Region: MULE; pfam10551 1205676002442 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1205676002443 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1205676002444 catalytic residues [active] 1205676002445 catalytic nucleophile [active] 1205676002446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205676002447 Probable transposase; Region: OrfB_IS605; pfam01385 1205676002448 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1205676002449 putative active site pocket [active] 1205676002450 dimerization interface [polypeptide binding]; other site 1205676002451 putative catalytic residue [active] 1205676002452 Phage-related replication protein [General function prediction only]; Region: COG4195 1205676002453 manganese transport protein MntH; Reviewed; Region: PRK00701 1205676002454 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1205676002455 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1205676002456 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1205676002457 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1205676002458 short chain dehydrogenase; Provisional; Region: PRK07814 1205676002459 classical (c) SDRs; Region: SDR_c; cd05233 1205676002460 NAD(P) binding site [chemical binding]; other site 1205676002461 active site 1205676002462 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1205676002463 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1205676002464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676002465 dimer interface [polypeptide binding]; other site 1205676002466 conserved gate region; other site 1205676002467 putative PBP binding loops; other site 1205676002468 ABC-ATPase subunit interface; other site 1205676002469 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1205676002470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676002471 dimer interface [polypeptide binding]; other site 1205676002472 conserved gate region; other site 1205676002473 putative PBP binding loops; other site 1205676002474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1205676002475 ABC-ATPase subunit interface; other site 1205676002476 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205676002477 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205676002478 active site 1205676002479 ATP binding site [chemical binding]; other site 1205676002480 substrate binding site [chemical binding]; other site 1205676002481 activation loop (A-loop); other site 1205676002482 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1205676002483 NHL repeat; Region: NHL; pfam01436 1205676002484 NHL repeat; Region: NHL; pfam01436 1205676002485 NHL repeat; Region: NHL; pfam01436 1205676002486 NHL repeat; Region: NHL; pfam01436 1205676002487 NHL repeat; Region: NHL; pfam01436 1205676002488 PBP superfamily domain; Region: PBP_like_2; cl17296 1205676002489 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271 1205676002490 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1205676002491 Walker A/P-loop; other site 1205676002492 ATP binding site [chemical binding]; other site 1205676002493 Q-loop/lid; other site 1205676002494 ABC transporter signature motif; other site 1205676002495 Walker B; other site 1205676002496 D-loop; other site 1205676002497 H-loop/switch region; other site 1205676002498 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 1205676002499 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1205676002500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676002501 dimer interface [polypeptide binding]; other site 1205676002502 conserved gate region; other site 1205676002503 putative PBP binding loops; other site 1205676002504 ABC-ATPase subunit interface; other site 1205676002505 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1205676002506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676002507 dimer interface [polypeptide binding]; other site 1205676002508 conserved gate region; other site 1205676002509 putative PBP binding loops; other site 1205676002510 ABC-ATPase subunit interface; other site 1205676002511 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1205676002512 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1205676002513 putative DNA binding site [nucleotide binding]; other site 1205676002514 putative homodimer interface [polypeptide binding]; other site 1205676002515 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1205676002516 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1205676002517 nucleotide binding site [chemical binding]; other site 1205676002518 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1205676002519 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1205676002520 active site 1205676002521 DNA binding site [nucleotide binding] 1205676002522 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1205676002523 DNA binding site [nucleotide binding] 1205676002524 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1205676002525 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1205676002526 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205676002527 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1205676002528 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1205676002529 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205676002530 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205676002531 anti sigma factor interaction site; other site 1205676002532 regulatory phosphorylation site [posttranslational modification]; other site 1205676002533 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205676002534 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1205676002535 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1205676002536 homodimer interface [polypeptide binding]; other site 1205676002537 active site 1205676002538 SAM binding site [chemical binding]; other site 1205676002539 PE family; Region: PE; pfam00934 1205676002540 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1205676002541 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1205676002542 putative DNA binding site [nucleotide binding]; other site 1205676002543 catalytic residue [active] 1205676002544 putative H2TH interface [polypeptide binding]; other site 1205676002545 putative catalytic residues [active] 1205676002546 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1205676002547 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1205676002548 short chain dehydrogenase; Provisional; Region: PRK08251 1205676002549 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1205676002550 putative NAD(P) binding site [chemical binding]; other site 1205676002551 active site 1205676002552 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1205676002553 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1205676002554 active site 1205676002555 dimer interface [polypeptide binding]; other site 1205676002556 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1205676002557 dimer interface [polypeptide binding]; other site 1205676002558 active site 1205676002559 Predicted esterase [General function prediction only]; Region: COG0627 1205676002560 hypothetical protein; Provisional; Region: PRK07857 1205676002561 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1205676002562 Part of AAA domain; Region: AAA_19; pfam13245 1205676002563 Family description; Region: UvrD_C_2; pfam13538 1205676002564 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1205676002565 Peptidase family M23; Region: Peptidase_M23; pfam01551 1205676002566 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1205676002567 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1205676002568 CoA-ligase; Region: Ligase_CoA; pfam00549 1205676002569 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1205676002570 CoA binding domain; Region: CoA_binding; smart00881 1205676002571 CoA-ligase; Region: Ligase_CoA; pfam00549 1205676002572 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1205676002573 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205676002574 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1205676002575 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1205676002576 active site 1205676002577 substrate binding site [chemical binding]; other site 1205676002578 cosubstrate binding site; other site 1205676002579 catalytic site [active] 1205676002580 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1205676002581 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1205676002582 purine monophosphate binding site [chemical binding]; other site 1205676002583 dimer interface [polypeptide binding]; other site 1205676002584 putative catalytic residues [active] 1205676002585 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1205676002586 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1205676002587 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1205676002588 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1205676002589 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1205676002590 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1205676002591 metal ion-dependent adhesion site (MIDAS); other site 1205676002592 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1205676002593 homotetrameric interface [polypeptide binding]; other site 1205676002594 putative active site [active] 1205676002595 metal binding site [ion binding]; metal-binding site 1205676002596 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1205676002597 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1205676002598 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 1205676002599 putative homodimer interface [polypeptide binding]; other site 1205676002600 putative homotetramer interface [polypeptide binding]; other site 1205676002601 allosteric switch controlling residues; other site 1205676002602 putative metal binding site [ion binding]; other site 1205676002603 putative homodimer-homodimer interface [polypeptide binding]; other site 1205676002604 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1205676002605 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1205676002606 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205676002607 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205676002608 enoyl-CoA hydratase; Provisional; Region: PRK07827 1205676002609 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676002610 substrate binding site [chemical binding]; other site 1205676002611 oxyanion hole (OAH) forming residues; other site 1205676002612 trimer interface [polypeptide binding]; other site 1205676002613 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676002614 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1205676002615 active site 1205676002616 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1205676002617 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205676002618 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205676002619 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1205676002620 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205676002621 carboxyltransferase (CT) interaction site; other site 1205676002622 biotinylation site [posttranslational modification]; other site 1205676002623 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205676002624 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205676002625 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676002626 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676002627 active site 1205676002628 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1205676002629 PE family; Region: PE; pfam00934 1205676002630 PE family; Region: PE; pfam00934 1205676002631 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1205676002632 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205676002633 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205676002634 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1205676002635 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205676002636 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205676002637 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1205676002638 PE family; Region: PE; pfam00934 1205676002639 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205676002640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205676002641 active site 1205676002642 phosphorylation site [posttranslational modification] 1205676002643 intermolecular recognition site; other site 1205676002644 dimerization interface [polypeptide binding]; other site 1205676002645 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205676002646 DNA binding site [nucleotide binding] 1205676002647 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1205676002648 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205676002649 dimerization interface [polypeptide binding]; other site 1205676002650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205676002651 dimer interface [polypeptide binding]; other site 1205676002652 phosphorylation site [posttranslational modification] 1205676002653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205676002654 ATP binding site [chemical binding]; other site 1205676002655 Mg2+ binding site [ion binding]; other site 1205676002656 G-X-G motif; other site 1205676002657 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1205676002658 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1205676002659 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1205676002660 MPT binding site; other site 1205676002661 trimer interface [polypeptide binding]; other site 1205676002662 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1205676002663 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1205676002664 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1205676002665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676002666 Walker A motif; other site 1205676002667 ATP binding site [chemical binding]; other site 1205676002668 Walker B motif; other site 1205676002669 Integrase core domain; Region: rve; pfam00665 1205676002670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1205676002671 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205676002672 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1205676002673 Walker A/P-loop; other site 1205676002674 ATP binding site [chemical binding]; other site 1205676002675 Q-loop/lid; other site 1205676002676 ABC transporter signature motif; other site 1205676002677 Walker B; other site 1205676002678 D-loop; other site 1205676002679 H-loop/switch region; other site 1205676002680 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1205676002681 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1205676002682 FtsX-like permease family; Region: FtsX; pfam02687 1205676002683 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1205676002684 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1205676002685 FtsX-like permease family; Region: FtsX; pfam02687 1205676002686 Predicted secreted hydrolase [General function prediction only]; Region: COG5621 1205676002687 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205676002688 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205676002689 substrate binding pocket [chemical binding]; other site 1205676002690 chain length determination region; other site 1205676002691 substrate-Mg2+ binding site; other site 1205676002692 catalytic residues [active] 1205676002693 aspartate-rich region 1; other site 1205676002694 active site lid residues [active] 1205676002695 aspartate-rich region 2; other site 1205676002696 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1205676002697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331 1205676002698 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1205676002699 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1205676002700 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1205676002701 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1205676002702 active site 1205676002703 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1205676002704 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1205676002705 dimer interface [polypeptide binding]; other site 1205676002706 putative functional site; other site 1205676002707 putative MPT binding site; other site 1205676002708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205676002709 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1205676002710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676002711 S-adenosylmethionine binding site [chemical binding]; other site 1205676002712 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205676002713 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205676002714 ligand binding site [chemical binding]; other site 1205676002715 flexible hinge region; other site 1205676002716 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1205676002717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205676002718 Coenzyme A binding pocket [chemical binding]; other site 1205676002719 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1205676002720 arginine deiminase; Provisional; Region: PRK01388 1205676002721 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1205676002722 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1205676002723 Predicted methyltransferases [General function prediction only]; Region: COG0313 1205676002724 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1205676002725 putative SAM binding site [chemical binding]; other site 1205676002726 putative homodimer interface [polypeptide binding]; other site 1205676002727 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1205676002728 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1205676002729 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1205676002730 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1205676002731 active site 1205676002732 HIGH motif; other site 1205676002733 KMSKS motif; other site 1205676002734 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1205676002735 tRNA binding surface [nucleotide binding]; other site 1205676002736 anticodon binding site; other site 1205676002737 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1205676002738 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1205676002739 active site 1205676002740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1205676002741 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1205676002742 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1205676002743 G5 domain; Region: G5; pfam07501 1205676002744 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1205676002745 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1205676002746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676002747 S-adenosylmethionine binding site [chemical binding]; other site 1205676002748 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1205676002749 Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311 1205676002750 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1205676002751 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1205676002752 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676002753 acyl-activating enzyme (AAE) consensus motif; other site 1205676002754 AMP binding site [chemical binding]; other site 1205676002755 active site 1205676002756 CoA binding site [chemical binding]; other site 1205676002757 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1205676002758 putative active site [active] 1205676002759 catalytic residue [active] 1205676002760 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1205676002761 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1205676002762 5S rRNA interface [nucleotide binding]; other site 1205676002763 CTC domain interface [polypeptide binding]; other site 1205676002764 L16 interface [polypeptide binding]; other site 1205676002765 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1205676002766 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1205676002767 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1205676002768 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205676002769 active site 1205676002770 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1205676002771 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1205676002772 Substrate binding site; other site 1205676002773 Mg++ binding site; other site 1205676002774 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1205676002775 active site 1205676002776 substrate binding site [chemical binding]; other site 1205676002777 CoA binding site [chemical binding]; other site 1205676002778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676002779 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676002780 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1205676002781 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1205676002782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205676002783 ATP binding site [chemical binding]; other site 1205676002784 putative Mg++ binding site [ion binding]; other site 1205676002785 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205676002786 nucleotide binding region [chemical binding]; other site 1205676002787 ATP-binding site [chemical binding]; other site 1205676002788 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1205676002789 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1205676002790 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1205676002791 homodimer interface [polypeptide binding]; other site 1205676002792 metal binding site [ion binding]; metal-binding site 1205676002793 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1205676002794 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1205676002795 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1205676002796 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1205676002797 enolase; Provisional; Region: eno; PRK00077 1205676002798 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1205676002799 dimer interface [polypeptide binding]; other site 1205676002800 metal binding site [ion binding]; metal-binding site 1205676002801 substrate binding pocket [chemical binding]; other site 1205676002802 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1205676002803 Septum formation initiator; Region: DivIC; pfam04977 1205676002804 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1205676002805 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1205676002806 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1205676002807 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1205676002808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205676002809 active site 1205676002810 phosphorylation site [posttranslational modification] 1205676002811 intermolecular recognition site; other site 1205676002812 dimerization interface [polypeptide binding]; other site 1205676002813 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205676002814 DNA binding site [nucleotide binding] 1205676002815 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1205676002816 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1205676002817 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1205676002818 Ligand Binding Site [chemical binding]; other site 1205676002819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205676002820 dimer interface [polypeptide binding]; other site 1205676002821 phosphorylation site [posttranslational modification] 1205676002822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205676002823 ATP binding site [chemical binding]; other site 1205676002824 Mg2+ binding site [ion binding]; other site 1205676002825 G-X-G motif; other site 1205676002826 K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680 1205676002827 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1205676002828 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205676002829 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205676002830 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1205676002831 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205676002832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205676002833 dimer interface [polypeptide binding]; other site 1205676002834 phosphorylation site [posttranslational modification] 1205676002835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205676002836 ATP binding site [chemical binding]; other site 1205676002837 Mg2+ binding site [ion binding]; other site 1205676002838 G-X-G motif; other site 1205676002839 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205676002840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205676002841 active site 1205676002842 phosphorylation site [posttranslational modification] 1205676002843 intermolecular recognition site; other site 1205676002844 dimerization interface [polypeptide binding]; other site 1205676002845 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205676002846 DNA binding site [nucleotide binding] 1205676002847 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1205676002848 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1205676002849 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1205676002850 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205676002851 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205676002852 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676002853 PPE family; Region: PPE; pfam00823 1205676002854 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676002855 PE family; Region: PE; pfam00934 1205676002856 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676002857 Transposase; Region: HTH_Tnp_1; pfam01527 1205676002858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205676002859 HTH-like domain; Region: HTH_21; pfam13276 1205676002860 Integrase core domain; Region: rve; pfam00665 1205676002861 Integrase core domain; Region: rve_3; pfam13683 1205676002862 Uncharacterized conserved protein [Function unknown]; Region: COG2253 1205676002863 Protein of unknown function (DUF2005); Region: DUF2005; pfam09407 1205676002864 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1205676002865 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205676002866 active site 1205676002867 DNA binding site [nucleotide binding] 1205676002868 Int/Topo IB signature motif; other site 1205676002869 Domain of unknown function (DUF427); Region: DUF427; cl00998 1205676002870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1205676002871 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1205676002872 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1205676002873 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1205676002874 dimer interface [polypeptide binding]; other site 1205676002875 acyl-activating enzyme (AAE) consensus motif; other site 1205676002876 putative active site [active] 1205676002877 AMP binding site [chemical binding]; other site 1205676002878 putative CoA binding site [chemical binding]; other site 1205676002879 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1205676002880 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1205676002881 hydrophobic ligand binding site; other site 1205676002882 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1205676002883 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1205676002884 putative active site [active] 1205676002885 putative dimer interface [polypeptide binding]; other site 1205676002886 Patatin-like phospholipase; Region: Patatin; pfam01734 1205676002887 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1205676002888 nucleophile elbow; other site 1205676002889 hypothetical protein; Provisional; Region: PRK10279 1205676002890 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1205676002891 active site 1205676002892 nucleophile elbow; other site 1205676002893 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1205676002894 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1205676002895 active site residue [active] 1205676002896 PE family; Region: PE; pfam00934 1205676002897 PE family; Region: PE; pfam00934 1205676002898 Predicted membrane protein [Function unknown]; Region: COG4425 1205676002899 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1205676002900 enoyl-CoA hydratase; Provisional; Region: PRK05862 1205676002901 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676002902 substrate binding site [chemical binding]; other site 1205676002903 oxyanion hole (OAH) forming residues; other site 1205676002904 trimer interface [polypeptide binding]; other site 1205676002905 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1205676002906 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676002907 substrate binding site [chemical binding]; other site 1205676002908 oxyanion hole (OAH) forming residues; other site 1205676002909 trimer interface [polypeptide binding]; other site 1205676002910 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1205676002911 Predicted membrane protein [Function unknown]; Region: COG4760 1205676002912 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1205676002913 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1205676002914 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1205676002915 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205676002916 dimer interface [polypeptide binding]; other site 1205676002917 active site 1205676002918 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1205676002919 active site 1205676002920 catalytic triad [active] 1205676002921 oxyanion hole [active] 1205676002922 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1205676002923 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1205676002924 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1205676002925 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1205676002926 dimer interface [polypeptide binding]; other site 1205676002927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676002928 catalytic residue [active] 1205676002929 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1205676002930 RDD family; Region: RDD; pfam06271 1205676002931 cystathionine gamma-synthase; Provisional; Region: PRK07811 1205676002932 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1205676002933 homodimer interface [polypeptide binding]; other site 1205676002934 substrate-cofactor binding pocket; other site 1205676002935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676002936 catalytic residue [active] 1205676002937 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1205676002938 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1205676002939 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1205676002940 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1205676002941 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1205676002942 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1205676002943 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1205676002944 catalytic residues [active] 1205676002945 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1205676002946 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1205676002947 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1205676002948 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1205676002949 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1205676002950 catalytic residue [active] 1205676002951 putative FPP diphosphate binding site; other site 1205676002952 putative FPP binding hydrophobic cleft; other site 1205676002953 dimer interface [polypeptide binding]; other site 1205676002954 putative IPP diphosphate binding site; other site 1205676002955 PE family; Region: PE; pfam00934 1205676002956 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1205676002957 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1205676002958 putative IPP diphosphate binding site; other site 1205676002959 PE family; Region: PE; pfam00934 1205676002960 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme 1205676002961 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205676002962 PE family; Region: PE; pfam00934 1205676002963 pantothenate kinase; Provisional; Region: PRK05439 1205676002964 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1205676002965 ATP-binding site [chemical binding]; other site 1205676002966 CoA-binding site [chemical binding]; other site 1205676002967 Mg2+-binding site [ion binding]; other site 1205676002968 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1205676002969 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1205676002970 dimer interface [polypeptide binding]; other site 1205676002971 active site 1205676002972 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1205676002973 folate binding site [chemical binding]; other site 1205676002974 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1205676002975 dinuclear metal binding motif [ion binding]; other site 1205676002976 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1205676002977 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1205676002978 putative active site [active] 1205676002979 PhoH-like protein; Region: PhoH; pfam02562 1205676002980 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1205676002981 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1205676002982 NodB motif; other site 1205676002983 active site 1205676002984 catalytic site [active] 1205676002985 metal binding site [ion binding]; metal-binding site 1205676002986 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1205676002987 Class II fumarases; Region: Fumarase_classII; cd01362 1205676002988 active site 1205676002989 tetramer interface [polypeptide binding]; other site 1205676002990 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1205676002991 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1205676002992 putative active site [active] 1205676002993 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1205676002994 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1205676002995 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1205676002996 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205676002997 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1205676002998 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205676002999 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205676003000 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205676003001 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1205676003002 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1205676003003 putative NAD(P) binding site [chemical binding]; other site 1205676003004 active site 1205676003005 putative substrate binding site [chemical binding]; other site 1205676003006 exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280 1205676003007 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1205676003008 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1205676003009 generic binding surface II; other site 1205676003010 generic binding surface I; other site 1205676003011 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1205676003012 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1205676003013 GTP-binding protein YchF; Reviewed; Region: PRK09601 1205676003014 YchF GTPase; Region: YchF; cd01900 1205676003015 G1 box; other site 1205676003016 GTP/Mg2+ binding site [chemical binding]; other site 1205676003017 Switch I region; other site 1205676003018 G2 box; other site 1205676003019 Switch II region; other site 1205676003020 G3 box; other site 1205676003021 G4 box; other site 1205676003022 G5 box; other site 1205676003023 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1205676003024 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1205676003025 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1205676003026 putative active site [active] 1205676003027 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1205676003028 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205676003029 cyclase homology domain; Region: CHD; cd07302 1205676003030 nucleotidyl binding site; other site 1205676003031 metal binding site [ion binding]; metal-binding site 1205676003032 dimer interface [polypeptide binding]; other site 1205676003033 glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871 1205676003034 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1205676003035 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1205676003036 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1205676003037 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1205676003038 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205676003039 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676003040 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205676003041 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1205676003042 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1205676003043 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1205676003044 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205676003045 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205676003046 active site 1205676003047 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205676003048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205676003049 non-specific DNA binding site [nucleotide binding]; other site 1205676003050 salt bridge; other site 1205676003051 sequence-specific DNA binding site [nucleotide binding]; other site 1205676003052 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1205676003053 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1205676003054 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1205676003055 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1205676003056 citrate synthase; Provisional; Region: PRK14033 1205676003057 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1205676003058 oxalacetate binding site [chemical binding]; other site 1205676003059 citrylCoA binding site [chemical binding]; other site 1205676003060 coenzyme A binding site [chemical binding]; other site 1205676003061 catalytic triad [active] 1205676003062 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1205676003063 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1205676003064 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1205676003065 THF binding site; other site 1205676003066 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1205676003067 substrate binding site [chemical binding]; other site 1205676003068 THF binding site; other site 1205676003069 zinc-binding site [ion binding]; other site 1205676003070 PPE family; Region: PPE; pfam00823 1205676003071 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676003072 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676003073 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1205676003074 active site 1205676003075 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205676003076 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676003077 substrate binding site [chemical binding]; other site 1205676003078 oxyanion hole (OAH) forming residues; other site 1205676003079 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1205676003080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1205676003081 CAAX protease self-immunity; Region: Abi; pfam02517 1205676003082 enoyl-CoA hydratase; Provisional; Region: PRK06688 1205676003083 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1205676003084 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676003085 trimer interface [polypeptide binding]; other site 1205676003086 enoyl-CoA hydratase; Provisional; Region: PRK06688 1205676003087 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676003088 substrate binding site [chemical binding]; other site 1205676003089 oxyanion hole (OAH) forming residues; other site 1205676003090 trimer interface [polypeptide binding]; other site 1205676003091 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205676003092 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205676003093 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1205676003094 NAD binding site [chemical binding]; other site 1205676003095 homodimer interface [polypeptide binding]; other site 1205676003096 homotetramer interface [polypeptide binding]; other site 1205676003097 active site 1205676003098 MMPL family; Region: MMPL; pfam03176 1205676003099 MMPL family; Region: MMPL; pfam03176 1205676003100 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11929527, 12657046 1205676003101 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11929527, 12657046 1205676003102 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1205676003103 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1205676003104 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1205676003105 NAD-dependent deacetylase; Provisional; Region: PRK00481 1205676003106 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1205676003107 NAD+ binding site [chemical binding]; other site 1205676003108 substrate binding site [chemical binding]; other site 1205676003109 Zn binding site [ion binding]; other site 1205676003110 Predicted transcriptional regulators [Transcription]; Region: COG1725 1205676003111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205676003112 DNA-binding site [nucleotide binding]; DNA binding site 1205676003113 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205676003114 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1205676003115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1205676003116 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1205676003117 uncharacterized HhH-GPD family protein; Region: TIGR03252 1205676003118 minor groove reading motif; other site 1205676003119 helix-hairpin-helix signature motif; other site 1205676003120 mannosyltransferase; Provisional; Region: pimE; PRK13375 1205676003121 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1205676003122 aromatic arch; other site 1205676003123 DCoH dimer interaction site [polypeptide binding]; other site 1205676003124 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1205676003125 DCoH tetramer interaction site [polypeptide binding]; other site 1205676003126 substrate binding site [chemical binding]; other site 1205676003127 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1205676003128 active site 1205676003129 8-oxo-dGMP binding site [chemical binding]; other site 1205676003130 nudix motif; other site 1205676003131 metal binding site [ion binding]; metal-binding site 1205676003132 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1205676003133 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1205676003134 [4Fe-4S] binding site [ion binding]; other site 1205676003135 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205676003136 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205676003137 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205676003138 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1205676003139 molybdopterin cofactor binding site; other site 1205676003140 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1205676003141 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 1205676003142 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1205676003143 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1205676003144 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1205676003145 G1 box; other site 1205676003146 putative GEF interaction site [polypeptide binding]; other site 1205676003147 GTP/Mg2+ binding site [chemical binding]; other site 1205676003148 Switch I region; other site 1205676003149 G2 box; other site 1205676003150 G3 box; other site 1205676003151 Switch II region; other site 1205676003152 G4 box; other site 1205676003153 G5 box; other site 1205676003154 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1205676003155 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1205676003156 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1205676003157 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1205676003158 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1205676003159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676003160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676003161 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676003162 PPE family; Region: PPE; pfam00823 1205676003163 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676003164 PE family; Region: PE; pfam00934 1205676003165 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1205676003166 PE family; Region: PE; pfam00934 1205676003167 FO synthase; Reviewed; Region: fbiC; PRK09234 1205676003168 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205676003169 FeS/SAM binding site; other site 1205676003170 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205676003171 FeS/SAM binding site; other site 1205676003172 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1205676003173 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1205676003174 active site 1205676003175 FMN binding site [chemical binding]; other site 1205676003176 2,4-decadienoyl-CoA binding site; other site 1205676003177 catalytic residue [active] 1205676003178 4Fe-4S cluster binding site [ion binding]; other site 1205676003179 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1205676003180 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205676003181 Predicted transcriptional regulators [Transcription]; Region: COG1695 1205676003182 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1205676003183 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1205676003184 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1205676003185 4Fe-4S binding domain; Region: Fer4; pfam00037 1205676003186 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1205676003187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205676003188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676003189 homodimer interface [polypeptide binding]; other site 1205676003190 catalytic residue [active] 1205676003191 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1205676003192 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1205676003193 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1205676003194 ATP binding site [chemical binding]; other site 1205676003195 putative Mg++ binding site [ion binding]; other site 1205676003196 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1205676003197 ATP-binding site [chemical binding]; other site 1205676003198 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205676003199 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676003200 active site 1205676003201 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205676003202 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205676003203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676003204 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205676003205 Enoylreductase; Region: PKS_ER; smart00829 1205676003206 NAD(P) binding site [chemical binding]; other site 1205676003207 KR domain; Region: KR; pfam08659 1205676003208 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205676003209 putative NADP binding site [chemical binding]; other site 1205676003210 active site 1205676003211 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676003212 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205676003213 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205676003214 PE-PPE domain; Region: PE-PPE; pfam08237 1205676003215 acyl-CoA synthetase; Validated; Region: PRK05850 1205676003216 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205676003217 acyl-activating enzyme (AAE) consensus motif; other site 1205676003218 active site 1205676003219 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205676003220 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205676003221 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1205676003222 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1205676003223 Glutamate binding site [chemical binding]; other site 1205676003224 NAD binding site [chemical binding]; other site 1205676003225 catalytic residues [active] 1205676003226 Proline dehydrogenase; Region: Pro_dh; cl03282 1205676003227 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1205676003228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205676003229 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205676003230 DNA binding residues [nucleotide binding] 1205676003231 haloalkane dehalogenase; Provisional; Region: PRK03204 1205676003232 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205676003233 catalytic site [active] 1205676003234 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676003235 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1205676003236 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205676003237 PGAP1-like protein; Region: PGAP1; pfam07819 1205676003238 acyl-CoA synthetase; Validated; Region: PRK07787 1205676003239 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676003240 acyl-activating enzyme (AAE) consensus motif; other site 1205676003241 AMP binding site [chemical binding]; other site 1205676003242 active site 1205676003243 CoA binding site [chemical binding]; other site 1205676003244 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205676003245 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205676003246 PE family; Region: PE; pfam00934 1205676003247 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676003248 PPE family; Region: PPE; pfam00823 1205676003249 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676003250 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1205676003251 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205676003252 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1205676003253 MULE transposase domain; Region: MULE; pfam10551 1205676003254 metabolite-proton symporter; Region: 2A0106; TIGR00883 1205676003255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676003256 putative substrate translocation pore; other site 1205676003257 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1205676003258 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1205676003259 putative trimer interface [polypeptide binding]; other site 1205676003260 putative CoA binding site [chemical binding]; other site 1205676003261 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1205676003262 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1205676003263 metal binding site [ion binding]; metal-binding site 1205676003264 putative dimer interface [polypeptide binding]; other site 1205676003265 TIGR00730 family protein; Region: TIGR00730 1205676003266 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1205676003267 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1205676003268 acyl-activating enzyme (AAE) consensus motif; other site 1205676003269 putative AMP binding site [chemical binding]; other site 1205676003270 putative active site [active] 1205676003271 putative CoA binding site [chemical binding]; other site 1205676003272 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1205676003273 dihydropteroate synthase; Region: DHPS; TIGR01496 1205676003274 substrate binding pocket [chemical binding]; other site 1205676003275 dimer interface [polypeptide binding]; other site 1205676003276 inhibitor binding site; inhibition site 1205676003277 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1205676003278 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205676003279 DivIVA domain; Region: DivI1A_domain; TIGR03544 1205676003280 DNA-3-methyladenine glycosylase I; Region: tag; TIGR00624 1205676003281 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1205676003282 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1205676003283 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205676003284 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1205676003285 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1205676003286 ligand binding site; other site 1205676003287 oligomer interface; other site 1205676003288 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1205676003289 dimer interface [polypeptide binding]; other site 1205676003290 N-terminal domain interface [polypeptide binding]; other site 1205676003291 sulfate 1 binding site; other site 1205676003292 PE family; Region: PE; pfam00934 1205676003293 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1205676003294 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205676003295 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1205676003296 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1205676003297 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1205676003298 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205676003299 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205676003300 Walker A/P-loop; other site 1205676003301 ATP binding site [chemical binding]; other site 1205676003302 Q-loop/lid; other site 1205676003303 ABC transporter signature motif; other site 1205676003304 Walker B; other site 1205676003305 D-loop; other site 1205676003306 H-loop/switch region; other site 1205676003307 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1205676003308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676003309 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1205676003310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676003311 S-adenosylmethionine binding site [chemical binding]; other site 1205676003312 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1205676003313 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205676003314 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205676003315 DNA binding residues [nucleotide binding] 1205676003316 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1205676003317 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1205676003318 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1205676003319 protein binding site [polypeptide binding]; other site 1205676003320 sec-independent translocase; Provisional; Region: PRK03100 1205676003321 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1205676003322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205676003323 active site 1205676003324 motif I; other site 1205676003325 motif II; other site 1205676003326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205676003327 Predicted membrane protein [Function unknown]; Region: COG3428 1205676003328 Bacterial PH domain; Region: DUF304; pfam03703 1205676003329 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1205676003330 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1205676003331 Domain of unknown function DUF59; Region: DUF59; cl00941 1205676003332 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1205676003333 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1205676003334 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1205676003335 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1205676003336 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1205676003337 catalytic residue [active] 1205676003338 Predicted membrane protein [Function unknown]; Region: COG4420 1205676003339 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1205676003340 MgtE intracellular N domain; Region: MgtE_N; smart00924 1205676003341 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1205676003342 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1205676003343 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1205676003344 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1205676003345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676003346 dimer interface [polypeptide binding]; other site 1205676003347 conserved gate region; other site 1205676003348 putative PBP binding loops; other site 1205676003349 ABC-ATPase subunit interface; other site 1205676003350 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205676003351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676003352 dimer interface [polypeptide binding]; other site 1205676003353 conserved gate region; other site 1205676003354 ABC-ATPase subunit interface; other site 1205676003355 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1205676003356 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1205676003357 Walker A/P-loop; other site 1205676003358 ATP binding site [chemical binding]; other site 1205676003359 Q-loop/lid; other site 1205676003360 ABC transporter signature motif; other site 1205676003361 Walker B; other site 1205676003362 D-loop; other site 1205676003363 H-loop/switch region; other site 1205676003364 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1205676003365 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1205676003366 oligomer interface [polypeptide binding]; other site 1205676003367 metal binding site [ion binding]; metal-binding site 1205676003368 metal binding site [ion binding]; metal-binding site 1205676003369 putative Cl binding site [ion binding]; other site 1205676003370 basic sphincter; other site 1205676003371 hydrophobic gate; other site 1205676003372 periplasmic entrance; other site 1205676003373 malate dehydrogenase; Provisional; Region: PRK05442 1205676003374 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1205676003375 NAD(P) binding site [chemical binding]; other site 1205676003376 dimer interface [polypeptide binding]; other site 1205676003377 malate binding site [chemical binding]; other site 1205676003378 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205676003379 PE family; Region: PE; pfam00934 1205676003380 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1205676003381 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1205676003382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676003383 NAD(P) binding site [chemical binding]; other site 1205676003384 active site 1205676003385 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1205676003386 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1205676003387 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1205676003388 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205676003389 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1205676003390 TPP-binding site [chemical binding]; other site 1205676003391 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1205676003392 dimer interface [polypeptide binding]; other site 1205676003393 PYR/PP interface [polypeptide binding]; other site 1205676003394 TPP binding site [chemical binding]; other site 1205676003395 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205676003396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676003397 putative substrate translocation pore; other site 1205676003398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676003399 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1205676003400 RNase_H superfamily; Region: RNase_H_2; pfam13482 1205676003401 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1205676003402 Part of AAA domain; Region: AAA_19; pfam13245 1205676003403 AAA domain; Region: AAA_12; pfam13087 1205676003404 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1205676003405 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1205676003406 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1205676003407 ATP binding site [chemical binding]; other site 1205676003408 Mg++ binding site [ion binding]; other site 1205676003409 motif III; other site 1205676003410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205676003411 nucleotide binding region [chemical binding]; other site 1205676003412 ATP-binding site [chemical binding]; other site 1205676003413 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1205676003414 putative RNA binding site [nucleotide binding]; other site 1205676003415 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1205676003416 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676003417 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676003418 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676003419 FAD binding domain; Region: FAD_binding_4; pfam01565 1205676003420 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1205676003421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676003422 H+ Antiporter protein; Region: 2A0121; TIGR00900 1205676003423 putative substrate translocation pore; other site 1205676003424 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1205676003425 Fe-S cluster binding site [ion binding]; other site 1205676003426 DNA binding site [nucleotide binding] 1205676003427 active site 1205676003428 hypothetical protein; Validated; Region: PRK05868 1205676003429 hypothetical protein; Provisional; Region: PRK07236 1205676003430 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205676003431 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205676003432 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1205676003433 HIT family signature motif; other site 1205676003434 catalytic residue [active] 1205676003435 amidase; Provisional; Region: PRK12470 1205676003436 Amidase; Region: Amidase; pfam01425 1205676003437 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205676003438 cyclase homology domain; Region: CHD; cd07302 1205676003439 nucleotidyl binding site; other site 1205676003440 metal binding site [ion binding]; metal-binding site 1205676003441 dimer interface [polypeptide binding]; other site 1205676003442 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205676003443 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205676003444 active site 1205676003445 ATP binding site [chemical binding]; other site 1205676003446 substrate binding site [chemical binding]; other site 1205676003447 activation loop (A-loop); other site 1205676003448 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205676003449 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205676003450 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205676003451 phosphopeptide binding site; other site 1205676003452 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205676003453 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205676003454 phosphopeptide binding site; other site 1205676003455 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1205676003456 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205676003457 Walker A/P-loop; other site 1205676003458 ATP binding site [chemical binding]; other site 1205676003459 Q-loop/lid; other site 1205676003460 ABC transporter signature motif; other site 1205676003461 Walker B; other site 1205676003462 D-loop; other site 1205676003463 H-loop/switch region; other site 1205676003464 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1205676003465 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1205676003466 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205676003467 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205676003468 active site 1205676003469 ATP binding site [chemical binding]; other site 1205676003470 substrate binding site [chemical binding]; other site 1205676003471 activation loop (A-loop); other site 1205676003472 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1205676003473 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1205676003474 DNA binding site [nucleotide binding] 1205676003475 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205676003476 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205676003477 phosphopeptide binding site; other site 1205676003478 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1205676003479 putative active site [active] 1205676003480 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1205676003481 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1205676003482 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205676003483 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205676003484 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1205676003485 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1205676003486 Walker A/P-loop; other site 1205676003487 ATP binding site [chemical binding]; other site 1205676003488 Q-loop/lid; other site 1205676003489 ABC transporter signature motif; other site 1205676003490 Walker B; other site 1205676003491 D-loop; other site 1205676003492 H-loop/switch region; other site 1205676003493 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1205676003494 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1205676003495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205676003496 Walker A/P-loop; other site 1205676003497 ATP binding site [chemical binding]; other site 1205676003498 Q-loop/lid; other site 1205676003499 ABC transporter signature motif; other site 1205676003500 Walker B; other site 1205676003501 D-loop; other site 1205676003502 H-loop/switch region; other site 1205676003503 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1205676003504 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1205676003505 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205676003506 catalytic core [active] 1205676003507 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1205676003508 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1205676003509 active site 1205676003510 metal binding site [ion binding]; metal-binding site 1205676003511 DNA binding site [nucleotide binding] 1205676003512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205676003513 Walker A/P-loop; other site 1205676003514 ATP binding site [chemical binding]; other site 1205676003515 choline dehydrogenase; Validated; Region: PRK02106 1205676003516 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205676003517 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1205676003518 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1205676003519 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1205676003520 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1205676003521 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205676003522 Walker A/P-loop; other site 1205676003523 ATP binding site [chemical binding]; other site 1205676003524 Q-loop/lid; other site 1205676003525 ABC transporter signature motif; other site 1205676003526 Walker B; other site 1205676003527 D-loop; other site 1205676003528 H-loop/switch region; other site 1205676003529 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205676003530 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205676003531 Walker A/P-loop; other site 1205676003532 ATP binding site [chemical binding]; other site 1205676003533 Q-loop/lid; other site 1205676003534 ABC transporter signature motif; other site 1205676003535 Walker B; other site 1205676003536 D-loop; other site 1205676003537 H-loop/switch region; other site 1205676003538 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1205676003539 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1205676003540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676003541 dimer interface [polypeptide binding]; other site 1205676003542 conserved gate region; other site 1205676003543 putative PBP binding loops; other site 1205676003544 ABC-ATPase subunit interface; other site 1205676003545 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1205676003546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676003547 dimer interface [polypeptide binding]; other site 1205676003548 conserved gate region; other site 1205676003549 putative PBP binding loops; other site 1205676003550 ABC-ATPase subunit interface; other site 1205676003551 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1205676003552 active site clefts [active] 1205676003553 zinc binding site [ion binding]; other site 1205676003554 dimer interface [polypeptide binding]; other site 1205676003555 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1205676003556 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1205676003557 Active Sites [active] 1205676003558 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1205676003559 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1205676003560 CysD dimerization site [polypeptide binding]; other site 1205676003561 G1 box; other site 1205676003562 putative GEF interaction site [polypeptide binding]; other site 1205676003563 GTP/Mg2+ binding site [chemical binding]; other site 1205676003564 Switch I region; other site 1205676003565 G2 box; other site 1205676003566 G3 box; other site 1205676003567 Switch II region; other site 1205676003568 G4 box; other site 1205676003569 G5 box; other site 1205676003570 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1205676003571 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1205676003572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205676003573 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1205676003574 Walker A/P-loop; other site 1205676003575 ligand-binding site [chemical binding]; other site 1205676003576 ATP binding site [chemical binding]; other site 1205676003577 Rrf2 family protein; Region: rrf2_super; TIGR00738 1205676003578 Transcriptional regulator; Region: Rrf2; pfam02082 1205676003579 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1205676003580 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1205676003581 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1205676003582 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1205676003583 Putative esterase; Region: Esterase; pfam00756 1205676003584 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1205676003585 Predicted membrane protein [Function unknown]; Region: COG4325 1205676003586 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1205676003587 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205676003588 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1205676003589 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1205676003590 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1205676003591 active site 1205676003592 HIGH motif; other site 1205676003593 KMSK motif region; other site 1205676003594 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1205676003595 tRNA binding surface [nucleotide binding]; other site 1205676003596 anticodon binding site; other site 1205676003597 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1205676003598 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1205676003599 active site 1205676003600 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205676003601 substrate binding site [chemical binding]; other site 1205676003602 catalytic residues [active] 1205676003603 dimer interface [polypeptide binding]; other site 1205676003604 homoserine dehydrogenase; Provisional; Region: PRK06349 1205676003605 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1205676003606 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1205676003607 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1205676003608 threonine synthase; Reviewed; Region: PRK06721 1205676003609 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1205676003610 homodimer interface [polypeptide binding]; other site 1205676003611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676003612 catalytic residue [active] 1205676003613 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1205676003614 transcription termination factor Rho; Provisional; Region: PRK12678 1205676003615 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1205676003616 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1205676003617 RNA binding site [nucleotide binding]; other site 1205676003618 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1205676003619 multimer interface [polypeptide binding]; other site 1205676003620 Walker A motif; other site 1205676003621 ATP binding site [chemical binding]; other site 1205676003622 Walker B motif; other site 1205676003623 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1205676003624 peptide chain release factor 1; Region: prfA; TIGR00019 1205676003625 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1205676003626 RF-1 domain; Region: RF-1; pfam00472 1205676003627 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1205676003628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676003629 S-adenosylmethionine binding site [chemical binding]; other site 1205676003630 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1205676003631 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1205676003632 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1205676003633 Mg++ binding site [ion binding]; other site 1205676003634 putative catalytic motif [active] 1205676003635 substrate binding site [chemical binding]; other site 1205676003636 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1205676003637 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1205676003638 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1205676003639 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1205676003640 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1205676003641 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1205676003642 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1205676003643 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1205676003644 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1205676003645 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1205676003646 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1205676003647 Walker A motif; other site 1205676003648 ATP binding site [chemical binding]; other site 1205676003649 Walker B motif; other site 1205676003650 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1205676003651 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1205676003652 core domain interface [polypeptide binding]; other site 1205676003653 delta subunit interface [polypeptide binding]; other site 1205676003654 epsilon subunit interface [polypeptide binding]; other site 1205676003655 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1205676003656 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1205676003657 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1205676003658 alpha subunit interaction interface [polypeptide binding]; other site 1205676003659 Walker A motif; other site 1205676003660 ATP binding site [chemical binding]; other site 1205676003661 Walker B motif; other site 1205676003662 inhibitor binding site; inhibition site 1205676003663 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1205676003664 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1205676003665 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1205676003666 gamma subunit interface [polypeptide binding]; other site 1205676003667 epsilon subunit interface [polypeptide binding]; other site 1205676003668 LBP interface [polypeptide binding]; other site 1205676003669 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1205676003670 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205676003671 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205676003672 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1205676003673 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1205676003674 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1205676003675 hinge; other site 1205676003676 active site 1205676003677 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1205676003678 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1205676003679 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1205676003680 DNA binding site [nucleotide binding] 1205676003681 active site 1205676003682 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1205676003683 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1205676003684 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1205676003685 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1205676003686 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1205676003687 minor groove reading motif; other site 1205676003688 helix-hairpin-helix signature motif; other site 1205676003689 substrate binding pocket [chemical binding]; other site 1205676003690 active site 1205676003691 HAMP domain; Region: HAMP; pfam00672 1205676003692 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205676003693 cyclase homology domain; Region: CHD; cd07302 1205676003694 nucleotidyl binding site; other site 1205676003695 metal binding site [ion binding]; metal-binding site 1205676003696 dimer interface [polypeptide binding]; other site 1205676003697 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205676003698 dimerization interface [polypeptide binding]; other site 1205676003699 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205676003700 cyclase homology domain; Region: CHD; cd07302 1205676003701 nucleotidyl binding site; other site 1205676003702 metal binding site [ion binding]; metal-binding site 1205676003703 dimer interface [polypeptide binding]; other site 1205676003704 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205676003705 dimerization interface [polypeptide binding]; other site 1205676003706 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205676003707 cyclase homology domain; Region: CHD; cd07302 1205676003708 nucleotidyl binding site; other site 1205676003709 metal binding site [ion binding]; metal-binding site 1205676003710 dimer interface [polypeptide binding]; other site 1205676003711 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1205676003712 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205676003713 dimerization interface [polypeptide binding]; other site 1205676003714 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205676003715 cyclase homology domain; Region: CHD; cd07302 1205676003716 nucleotidyl binding site; other site 1205676003717 metal binding site [ion binding]; metal-binding site 1205676003718 dimer interface [polypeptide binding]; other site 1205676003719 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1205676003720 hypothetical protein; Provisional; Region: PRK03298 1205676003721 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205676003722 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1205676003723 dimer interface [polypeptide binding]; other site 1205676003724 substrate binding site [chemical binding]; other site 1205676003725 metal binding site [ion binding]; metal-binding site 1205676003726 putative acyltransferase; Provisional; Region: PRK05790 1205676003727 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205676003728 dimer interface [polypeptide binding]; other site 1205676003729 active site 1205676003730 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1205676003731 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1205676003732 PE family; Region: PE; pfam00934 1205676003733 glycogen branching enzyme; Provisional; Region: PRK05402 1205676003734 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1205676003735 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1205676003736 active site 1205676003737 catalytic site [active] 1205676003738 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1205676003739 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1205676003740 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1205676003741 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1205676003742 active site 1205676003743 homodimer interface [polypeptide binding]; other site 1205676003744 catalytic site [active] 1205676003745 acceptor binding site [chemical binding]; other site 1205676003746 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1205676003747 putative homodimer interface [polypeptide binding]; other site 1205676003748 putative active site pocket [active] 1205676003749 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1205676003750 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1205676003751 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1205676003752 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1205676003753 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1205676003754 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1205676003755 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1205676003756 active site 1205676003757 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1205676003758 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1205676003759 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1205676003760 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1205676003761 putative active site pocket [active] 1205676003762 cleavage site 1205676003763 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1205676003764 MPN+ (JAMM) motif; other site 1205676003765 Zinc-binding site [ion binding]; other site 1205676003766 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1205676003767 MoaE interaction surface [polypeptide binding]; other site 1205676003768 MoeB interaction surface [polypeptide binding]; other site 1205676003769 thiocarboxylated glycine; other site 1205676003770 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1205676003771 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1205676003772 dimer interface [polypeptide binding]; other site 1205676003773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676003774 catalytic residue [active] 1205676003775 Rhomboid family; Region: Rhomboid; pfam01694 1205676003776 glutamate racemase; Provisional; Region: PRK00865 1205676003777 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1205676003778 ribonuclease PH; Reviewed; Region: rph; PRK00173 1205676003779 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1205676003780 hexamer interface [polypeptide binding]; other site 1205676003781 active site 1205676003782 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1205676003783 active site 1205676003784 dimerization interface [polypeptide binding]; other site 1205676003785 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1205676003786 Glucitol operon activator [Transcription]; Region: GutM; COG4578 1205676003787 acyl carrier protein; Validated; Region: PRK05883 1205676003788 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1205676003789 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205676003790 acyl-activating enzyme (AAE) consensus motif; other site 1205676003791 active site 1205676003792 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676003793 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676003794 active site 1205676003795 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1205676003796 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1205676003797 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1205676003798 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1205676003799 FAD binding pocket [chemical binding]; other site 1205676003800 FAD binding motif [chemical binding]; other site 1205676003801 phosphate binding motif [ion binding]; other site 1205676003802 NAD binding pocket [chemical binding]; other site 1205676003803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205676003804 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1205676003805 Walker A/P-loop; other site 1205676003806 ATP binding site [chemical binding]; other site 1205676003807 Q-loop/lid; other site 1205676003808 ABC transporter signature motif; other site 1205676003809 Walker B; other site 1205676003810 D-loop; other site 1205676003811 H-loop/switch region; other site 1205676003812 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205676003813 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205676003814 Walker A/P-loop; other site 1205676003815 ATP binding site [chemical binding]; other site 1205676003816 Q-loop/lid; other site 1205676003817 ABC transporter signature motif; other site 1205676003818 Walker B; other site 1205676003819 D-loop; other site 1205676003820 H-loop/switch region; other site 1205676003821 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1205676003822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676003823 NAD(P) binding site [chemical binding]; other site 1205676003824 active site 1205676003825 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1205676003826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676003827 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1205676003828 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1205676003829 GAF domain; Region: GAF; pfam01590 1205676003830 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1205676003831 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1205676003832 metal binding site [ion binding]; metal-binding site 1205676003833 active site 1205676003834 I-site; other site 1205676003835 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1205676003836 hypothetical protein; Provisional; Region: PRK07877 1205676003837 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1205676003838 ATP binding site [chemical binding]; other site 1205676003839 substrate interface [chemical binding]; other site 1205676003840 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205676003841 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1205676003842 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205676003843 cyclase homology domain; Region: CHD; cd07302 1205676003844 nucleotidyl binding site; other site 1205676003845 dimer interface [polypeptide binding]; other site 1205676003846 metal binding site [ion binding]; metal-binding site 1205676003847 AAA ATPase domain; Region: AAA_16; pfam13191 1205676003848 Predicted ATPase [General function prediction only]; Region: COG3903 1205676003849 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205676003850 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205676003851 DNA binding residues [nucleotide binding] 1205676003852 dimerization interface [polypeptide binding]; other site 1205676003853 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205676003854 cyclase homology domain; Region: CHD; cd07302 1205676003855 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1205676003856 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205676003857 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676003858 PPE family; Region: PPE; pfam00823 1205676003859 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676003860 PAS fold; Region: PAS_4; pfam08448 1205676003861 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1205676003862 putative active site [active] 1205676003863 heme pocket [chemical binding]; other site 1205676003864 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1205676003865 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1205676003866 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1205676003867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1205676003868 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205676003869 anti sigma factor interaction site; other site 1205676003870 regulatory phosphorylation site [posttranslational modification]; other site 1205676003871 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205676003872 anti sigma factor interaction site; other site 1205676003873 regulatory phosphorylation site [posttranslational modification]; other site 1205676003874 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1205676003875 synthetase active site [active] 1205676003876 NTP binding site [chemical binding]; other site 1205676003877 metal binding site [ion binding]; metal-binding site 1205676003878 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205676003879 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205676003880 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1205676003881 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173 1205676003882 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1205676003883 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1205676003884 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1205676003885 malonyl-CoA binding site [chemical binding]; other site 1205676003886 dimer interface [polypeptide binding]; other site 1205676003887 active site 1205676003888 product binding site; other site 1205676003889 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1205676003890 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1205676003891 uncharacterized domain; Region: TIGR00702 1205676003892 YcaO-like family; Region: YcaO; pfam02624 1205676003893 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1205676003894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676003895 S-adenosylmethionine binding site [chemical binding]; other site 1205676003896 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205676003897 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205676003898 active site 1205676003899 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1205676003900 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1205676003901 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1205676003902 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1205676003903 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1205676003904 dihydroorotase; Validated; Region: pyrC; PRK09357 1205676003905 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205676003906 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1205676003907 active site 1205676003908 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1205676003909 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1205676003910 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1205676003911 catalytic site [active] 1205676003912 subunit interface [polypeptide binding]; other site 1205676003913 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1205676003914 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205676003915 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205676003916 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1205676003917 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205676003918 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205676003919 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1205676003920 IMP binding site; other site 1205676003921 dimer interface [polypeptide binding]; other site 1205676003922 interdomain contacts; other site 1205676003923 partial ornithine binding site; other site 1205676003924 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1205676003925 active site 1205676003926 dimer interface [polypeptide binding]; other site 1205676003927 PE family; Region: PE; pfam00934 1205676003928 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676003929 PPE family; Region: PPE; pfam00823 1205676003930 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1205676003931 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1205676003932 catalytic site [active] 1205676003933 G-X2-G-X-G-K; other site 1205676003934 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1205676003935 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1205676003936 Flavoprotein; Region: Flavoprotein; pfam02441 1205676003937 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1205676003938 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1205676003939 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1205676003940 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1205676003941 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1205676003942 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205676003943 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205676003944 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676003945 Cytochrome P450; Region: p450; cl12078 1205676003946 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1205676003947 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205676003948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205676003949 PE family; Region: PE; pfam00934 1205676003950 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1205676003951 oligomeric interface; other site 1205676003952 putative active site [active] 1205676003953 homodimer interface [polypeptide binding]; other site 1205676003954 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205676003955 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205676003956 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205676003957 substrate binding pocket [chemical binding]; other site 1205676003958 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205676003959 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205676003960 substrate binding pocket [chemical binding]; other site 1205676003961 Predicted membrane protein [Function unknown]; Region: COG3714 1205676003962 primosome assembly protein PriA; Provisional; Region: PRK14873 1205676003963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676003964 S-adenosylmethionine binding site [chemical binding]; other site 1205676003965 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205676003966 MarR family; Region: MarR; pfam01047 1205676003967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676003968 S-adenosylmethionine binding site [chemical binding]; other site 1205676003969 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1205676003970 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1205676003971 putative active site [active] 1205676003972 substrate binding site [chemical binding]; other site 1205676003973 putative cosubstrate binding site; other site 1205676003974 catalytic site [active] 1205676003975 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1205676003976 substrate binding site [chemical binding]; other site 1205676003977 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1205676003978 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1205676003979 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1205676003980 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1205676003981 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1205676003982 substrate binding site [chemical binding]; other site 1205676003983 hexamer interface [polypeptide binding]; other site 1205676003984 metal binding site [ion binding]; metal-binding site 1205676003985 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1205676003986 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1205676003987 catalytic motif [active] 1205676003988 Zn binding site [ion binding]; other site 1205676003989 RibD C-terminal domain; Region: RibD_C; pfam01872 1205676003990 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205676003991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676003992 putative substrate translocation pore; other site 1205676003993 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1205676003994 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1205676003995 Lumazine binding domain; Region: Lum_binding; pfam00677 1205676003996 Lumazine binding domain; Region: Lum_binding; pfam00677 1205676003997 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1205676003998 catalytic residue [active] 1205676003999 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1205676004000 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1205676004001 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1205676004002 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1205676004003 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1205676004004 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1205676004005 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1205676004006 dimerization interface [polypeptide binding]; other site 1205676004007 active site 1205676004008 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1205676004009 homopentamer interface [polypeptide binding]; other site 1205676004010 active site 1205676004011 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1205676004012 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205676004013 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1205676004014 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1205676004015 putative sugar binding sites [chemical binding]; other site 1205676004016 Q-X-W motif; other site 1205676004017 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1205676004018 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1205676004019 GIY-YIG motif/motif A; other site 1205676004020 active site 1205676004021 catalytic site [active] 1205676004022 putative DNA binding site [nucleotide binding]; other site 1205676004023 metal binding site [ion binding]; metal-binding site 1205676004024 UvrB/uvrC motif; Region: UVR; pfam02151 1205676004025 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1205676004026 Helix-hairpin-helix motif; Region: HHH; pfam00633 1205676004027 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1205676004028 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1205676004029 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1205676004030 phosphate binding site [ion binding]; other site 1205676004031 putative substrate binding pocket [chemical binding]; other site 1205676004032 dimer interface [polypeptide binding]; other site 1205676004033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1205676004034 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1205676004035 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205676004036 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205676004037 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205676004038 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205676004039 acyl-CoA synthetase; Provisional; Region: PRK13382 1205676004040 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1205676004041 acyl-activating enzyme (AAE) consensus motif; other site 1205676004042 putative AMP binding site [chemical binding]; other site 1205676004043 putative active site [active] 1205676004044 putative CoA binding site [chemical binding]; other site 1205676004045 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205676004046 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1205676004047 putative acyl-acceptor binding pocket; other site 1205676004048 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205676004049 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205676004050 PE family; Region: PE; pfam00934 1205676004051 PE-PPE domain; Region: PE-PPE; pfam08237 1205676004052 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1205676004053 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1205676004054 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205676004055 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1205676004056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1205676004057 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205676004058 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1205676004059 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1205676004060 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1205676004061 Phosphoglycerate kinase; Region: PGK; pfam00162 1205676004062 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1205676004063 substrate binding site [chemical binding]; other site 1205676004064 hinge regions; other site 1205676004065 ADP binding site [chemical binding]; other site 1205676004066 catalytic site [active] 1205676004067 triosephosphate isomerase; Provisional; Region: PRK14567 1205676004068 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1205676004069 substrate binding site [chemical binding]; other site 1205676004070 dimer interface [polypeptide binding]; other site 1205676004071 catalytic triad [active] 1205676004072 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205676004073 Preprotein translocase SecG subunit; Region: SecG; cl09123 1205676004074 PE family; Region: PE; pfam00934 1205676004075 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1205676004076 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1205676004077 molybdopterin cofactor binding site [chemical binding]; other site 1205676004078 substrate binding site [chemical binding]; other site 1205676004079 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1205676004080 molybdopterin cofactor binding site; other site 1205676004081 hydrophobic ligand binding site; other site 1205676004082 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1205676004083 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1205676004084 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1205676004085 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1205676004086 putative active site [active] 1205676004087 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1205676004088 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 1205676004089 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1205676004090 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1205676004091 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1205676004092 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1205676004093 putative active site [active] 1205676004094 transaldolase; Provisional; Region: PRK03903 1205676004095 catalytic residue [active] 1205676004096 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1205676004097 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1205676004098 TPP-binding site [chemical binding]; other site 1205676004099 dimer interface [polypeptide binding]; other site 1205676004100 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1205676004101 PYR/PP interface [polypeptide binding]; other site 1205676004102 dimer interface [polypeptide binding]; other site 1205676004103 TPP binding site [chemical binding]; other site 1205676004104 PE family; Region: PE; pfam00934 1205676004105 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1205676004106 UbiA prenyltransferase family; Region: UbiA; pfam01040 1205676004107 PE family; Region: PE; pfam00934 1205676004108 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205676004109 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205676004110 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1205676004111 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1205676004112 NADP binding site [chemical binding]; other site 1205676004113 dimer interface [polypeptide binding]; other site 1205676004114 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1205676004115 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1205676004116 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1205676004117 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205676004118 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205676004119 Walker A/P-loop; other site 1205676004120 ATP binding site [chemical binding]; other site 1205676004121 Q-loop/lid; other site 1205676004122 ABC transporter signature motif; other site 1205676004123 Walker B; other site 1205676004124 D-loop; other site 1205676004125 H-loop/switch region; other site 1205676004126 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1205676004127 Predicted transcriptional regulator [Transcription]; Region: COG2345 1205676004128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205676004129 putative DNA binding site [nucleotide binding]; other site 1205676004130 putative Zn2+ binding site [ion binding]; other site 1205676004131 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1205676004132 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1205676004133 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1205676004134 protein-splicing catalytic site; other site 1205676004135 thioester formation/cholesterol transfer; other site 1205676004136 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1205676004137 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1205676004138 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1205676004139 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1205676004140 FeS assembly protein SufD; Region: sufD; TIGR01981 1205676004141 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1205676004142 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1205676004143 Walker A/P-loop; other site 1205676004144 ATP binding site [chemical binding]; other site 1205676004145 Q-loop/lid; other site 1205676004146 ABC transporter signature motif; other site 1205676004147 Walker B; other site 1205676004148 D-loop; other site 1205676004149 H-loop/switch region; other site 1205676004150 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1205676004151 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1205676004152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205676004153 catalytic residue [active] 1205676004154 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1205676004155 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1205676004156 trimerization site [polypeptide binding]; other site 1205676004157 active site 1205676004158 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1205676004159 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1205676004160 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1205676004161 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676004162 active site 1205676004163 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1205676004164 PE family; Region: PE; pfam00934 1205676004165 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1205676004166 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205676004167 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1205676004168 catalytic residues [active] 1205676004169 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1205676004170 catalytic residues [active] 1205676004171 enoyl-CoA hydratase; Provisional; Region: PRK05864 1205676004172 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676004173 substrate binding site [chemical binding]; other site 1205676004174 oxyanion hole (OAH) forming residues; other site 1205676004175 trimer interface [polypeptide binding]; other site 1205676004176 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1205676004177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205676004178 Walker A/P-loop; other site 1205676004179 ATP binding site [chemical binding]; other site 1205676004180 Q-loop/lid; other site 1205676004181 ABC transporter signature motif; other site 1205676004182 Walker B; other site 1205676004183 D-loop; other site 1205676004184 H-loop/switch region; other site 1205676004185 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205676004186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676004187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676004188 aconitate hydratase; Validated; Region: PRK09277 1205676004189 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1205676004190 substrate binding site [chemical binding]; other site 1205676004191 ligand binding site [chemical binding]; other site 1205676004192 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1205676004193 substrate binding site [chemical binding]; other site 1205676004194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1205676004195 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205676004196 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205676004197 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205676004198 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205676004199 MoxR-like ATPases [General function prediction only]; Region: COG0714 1205676004200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676004201 Walker A motif; other site 1205676004202 ATP binding site [chemical binding]; other site 1205676004203 Walker B motif; other site 1205676004204 arginine finger; other site 1205676004205 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1205676004206 Protein of unknown function DUF58; Region: DUF58; pfam01882 1205676004207 hypothetical protein; Provisional; Region: PRK13685 1205676004208 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1205676004209 metal ion-dependent adhesion site (MIDAS); other site 1205676004210 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1205676004211 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1205676004212 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1205676004213 NAD(P) binding site [chemical binding]; other site 1205676004214 homotetramer interface [polypeptide binding]; other site 1205676004215 homodimer interface [polypeptide binding]; other site 1205676004216 active site 1205676004217 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1205676004218 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1205676004219 NAD binding site [chemical binding]; other site 1205676004220 homotetramer interface [polypeptide binding]; other site 1205676004221 homodimer interface [polypeptide binding]; other site 1205676004222 substrate binding site [chemical binding]; other site 1205676004223 active site 1205676004224 ferrochelatase; Reviewed; Region: hemH; PRK00035 1205676004225 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1205676004226 C-terminal domain interface [polypeptide binding]; other site 1205676004227 active site 1205676004228 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1205676004229 active site 1205676004230 N-terminal domain interface [polypeptide binding]; other site 1205676004231 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1205676004232 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1205676004233 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1205676004234 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1205676004235 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1205676004236 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1205676004237 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1205676004238 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1205676004239 heterodimer interface [polypeptide binding]; other site 1205676004240 substrate interaction site [chemical binding]; other site 1205676004241 Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) [Lipid metabolism]; Region: Sbm; COG2185 1205676004242 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1205676004243 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1205676004244 active site 1205676004245 substrate binding site [chemical binding]; other site 1205676004246 coenzyme B12 binding site [chemical binding]; other site 1205676004247 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1205676004248 B12 binding site [chemical binding]; other site 1205676004249 cobalt ligand [ion binding]; other site 1205676004250 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205676004251 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1205676004252 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1205676004253 Walker A; other site 1205676004254 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205676004255 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205676004256 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205676004257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676004258 S-adenosylmethionine binding site [chemical binding]; other site 1205676004259 Uncharacterized conserved protein [Function unknown]; Region: COG3360 1205676004260 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15024109; Product type pe : putative enzyme 1205676004261 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1205676004262 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1205676004263 Ligand binding site; other site 1205676004264 Putative Catalytic site; other site 1205676004265 DXD motif; other site 1205676004266 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1205676004267 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1205676004268 active site 1205676004269 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1205676004270 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205676004271 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1205676004272 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1205676004273 inhibitor-cofactor binding pocket; inhibition site 1205676004274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676004275 catalytic residue [active] 1205676004276 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1205676004277 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1205676004278 putative trimer interface [polypeptide binding]; other site 1205676004279 putative CoA binding site [chemical binding]; other site 1205676004280 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1205676004281 S-adenosylmethionine binding site [chemical binding]; other site 1205676004282 WbqC-like protein family; Region: WbqC; pfam08889 1205676004283 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1205676004284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676004285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676004286 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205676004287 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1205676004288 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1205676004289 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1205676004290 NADP-binding site; other site 1205676004291 homotetramer interface [polypeptide binding]; other site 1205676004292 substrate binding site [chemical binding]; other site 1205676004293 homodimer interface [polypeptide binding]; other site 1205676004294 active site 1205676004295 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1205676004296 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1205676004297 NADP binding site [chemical binding]; other site 1205676004298 active site 1205676004299 putative substrate binding site [chemical binding]; other site 1205676004300 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1205676004301 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1205676004302 metal-binding site 1205676004303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676004304 S-adenosylmethionine binding site [chemical binding]; other site 1205676004305 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205676004306 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205676004307 active site 1205676004308 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1205676004309 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205676004310 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1205676004311 active site 1205676004312 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1205676004313 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205676004314 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205676004315 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205676004316 active site 1205676004317 acyl-CoA synthetase; Validated; Region: PRK05850 1205676004318 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205676004319 acyl-activating enzyme (AAE) consensus motif; other site 1205676004320 active site 1205676004321 Transport protein; Region: actII; TIGR00833 1205676004322 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205676004323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676004324 S-adenosylmethionine binding site [chemical binding]; other site 1205676004325 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205676004326 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205676004327 homodimer interface [polypeptide binding]; other site 1205676004328 active site 1205676004329 TDP-binding site; other site 1205676004330 acceptor substrate-binding pocket; other site 1205676004331 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1205676004332 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1205676004333 Probable Catalytic site; other site 1205676004334 metal-binding site 1205676004335 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205676004336 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205676004337 homodimer interface [polypeptide binding]; other site 1205676004338 active site 1205676004339 TDP-binding site; other site 1205676004340 acceptor substrate-binding pocket; other site 1205676004341 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205676004342 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676004343 active site 1205676004344 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1205676004345 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205676004346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676004347 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205676004348 Enoylreductase; Region: PKS_ER; smart00829 1205676004349 NAD(P) binding site [chemical binding]; other site 1205676004350 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205676004351 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205676004352 putative NADP binding site [chemical binding]; other site 1205676004353 active site 1205676004354 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676004355 acyl-CoA synthetase; Validated; Region: PRK05850 1205676004356 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205676004357 acyl-activating enzyme (AAE) consensus motif; other site 1205676004358 active site 1205676004359 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1205676004360 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205676004361 NAD(P) binding site [chemical binding]; other site 1205676004362 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1205676004363 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1205676004364 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1205676004365 CoenzymeA binding site [chemical binding]; other site 1205676004366 subunit interaction site [polypeptide binding]; other site 1205676004367 PHB binding site; other site 1205676004368 Nitronate monooxygenase; Region: NMO; pfam03060 1205676004369 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1205676004370 FMN binding site [chemical binding]; other site 1205676004371 substrate binding site [chemical binding]; other site 1205676004372 putative catalytic residue [active] 1205676004373 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676004374 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1205676004375 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1205676004376 HIGH motif; other site 1205676004377 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1205676004378 active site 1205676004379 KMSKS motif; other site 1205676004380 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1205676004381 tRNA binding surface [nucleotide binding]; other site 1205676004382 anticodon binding site; other site 1205676004383 DNA polymerase IV; Provisional; Region: PRK03348 1205676004384 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1205676004385 active site 1205676004386 DNA binding site [nucleotide binding] 1205676004387 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1205676004388 active site 1205676004389 homodimer interface [polypeptide binding]; other site 1205676004390 homotetramer interface [polypeptide binding]; other site 1205676004391 lipoprotein signal peptidase; Provisional; Region: PRK14764 1205676004392 lipoprotein signal peptidase; Provisional; Region: PRK14787 1205676004393 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1205676004394 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1205676004395 active site 1205676004396 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1205676004397 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1205676004398 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1205676004399 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1205676004400 apolar tunnel; other site 1205676004401 heme binding site [chemical binding]; other site 1205676004402 dimerization interface [polypeptide binding]; other site 1205676004403 short chain dehydrogenase; Provisional; Region: PRK05866 1205676004404 classical (c) SDRs; Region: SDR_c; cd05233 1205676004405 NAD(P) binding site [chemical binding]; other site 1205676004406 active site 1205676004407 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1205676004408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676004409 NAD(P) binding site [chemical binding]; other site 1205676004410 active site 1205676004411 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1205676004412 hydrophobic ligand binding site; other site 1205676004413 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1205676004414 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1205676004415 active site 1205676004416 PHP Thumb interface [polypeptide binding]; other site 1205676004417 metal binding site [ion binding]; metal-binding site 1205676004418 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1205676004419 generic binding surface II; other site 1205676004420 generic binding surface I; other site 1205676004421 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676004422 PPE family; Region: PPE; pfam00823 1205676004423 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676004424 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676004425 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1205676004426 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1205676004427 acyl-activating enzyme (AAE) consensus motif; other site 1205676004428 putative AMP binding site [chemical binding]; other site 1205676004429 putative active site [active] 1205676004430 putative CoA binding site [chemical binding]; other site 1205676004431 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1205676004432 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1205676004433 putative acyl-acceptor binding pocket; other site 1205676004434 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 1205676004435 L-aspartate oxidase; Provisional; Region: PRK06175 1205676004436 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1205676004437 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1205676004438 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1205676004439 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 1205676004440 Iron-sulfur protein interface; other site 1205676004441 proximal heme binding site [chemical binding]; other site 1205676004442 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1205676004443 Iron-sulfur protein interface; other site 1205676004444 proximal quinone binding site [chemical binding]; other site 1205676004445 C-subunit interface; other site 1205676004446 distal quinone binding site; other site 1205676004447 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676004448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676004449 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205676004450 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205676004451 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205676004452 threonine dehydratase; Validated; Region: PRK08639 1205676004453 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1205676004454 tetramer interface [polypeptide binding]; other site 1205676004455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676004456 catalytic residue [active] 1205676004457 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1205676004458 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205676004459 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205676004460 putative active site [active] 1205676004461 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 10658666, 12775759; Product type e : enzyme 1205676004462 Integrase core domain; Region: rve; pfam00665 1205676004463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1205676004464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676004465 Walker A motif; other site 1205676004466 ATP binding site [chemical binding]; other site 1205676004467 Walker B motif; other site 1205676004468 Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 10658666, 12775759; Product type e : enzyme 1205676004469 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1205676004470 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1205676004471 active site 1205676004472 catalytic site [active] 1205676004473 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1205676004474 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1205676004475 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1205676004476 active site 1205676004477 catalytic site [active] 1205676004478 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1205676004479 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205676004480 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205676004481 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1205676004482 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205676004483 inhibitor-cofactor binding pocket; inhibition site 1205676004484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676004485 catalytic residue [active] 1205676004486 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1205676004487 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1205676004488 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205676004489 catalytic residue [active] 1205676004490 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1205676004491 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1205676004492 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205676004493 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205676004494 active site 1205676004495 biotin synthase; Validated; Region: PRK06256 1205676004496 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205676004497 FeS/SAM binding site; other site 1205676004498 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1205676004499 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1205676004500 Secretory lipase; Region: LIP; pfam03583 1205676004501 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1205676004502 nudix motif; other site 1205676004503 quinolinate synthetase; Provisional; Region: PRK09375 1205676004504 L-aspartate oxidase; Provisional; Region: PRK07804 1205676004505 L-aspartate oxidase; Provisional; Region: PRK06175 1205676004506 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1205676004507 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1205676004508 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1205676004509 dimerization interface [polypeptide binding]; other site 1205676004510 active site 1205676004511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676004512 S-adenosylmethionine binding site [chemical binding]; other site 1205676004513 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1205676004514 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1205676004515 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1205676004516 NAD binding site [chemical binding]; other site 1205676004517 dimerization interface [polypeptide binding]; other site 1205676004518 product binding site; other site 1205676004519 substrate binding site [chemical binding]; other site 1205676004520 zinc binding site [ion binding]; other site 1205676004521 catalytic residues [active] 1205676004522 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1205676004523 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205676004524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676004525 homodimer interface [polypeptide binding]; other site 1205676004526 catalytic residue [active] 1205676004527 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1205676004528 4-fold oligomerization interface [polypeptide binding]; other site 1205676004529 putative active site pocket [active] 1205676004530 metal binding residues [ion binding]; metal-binding site 1205676004531 3-fold/trimer interface [polypeptide binding]; other site 1205676004532 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1205676004533 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1205676004534 putative active site [active] 1205676004535 oxyanion strand; other site 1205676004536 catalytic triad [active] 1205676004537 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1205676004538 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1205676004539 catalytic residues [active] 1205676004540 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1205676004541 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1205676004542 active site 1205676004543 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1205676004544 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1205676004545 substrate binding site [chemical binding]; other site 1205676004546 glutamase interaction surface [polypeptide binding]; other site 1205676004547 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1205676004548 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1205676004549 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1205676004550 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1205676004551 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1205676004552 catalytic triad [active] 1205676004553 anthranilate synthase component I; Provisional; Region: PRK13571 1205676004554 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1205676004555 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1205676004556 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1205676004557 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1205676004558 active site 1205676004559 ribulose/triose binding site [chemical binding]; other site 1205676004560 phosphate binding site [ion binding]; other site 1205676004561 substrate (anthranilate) binding pocket [chemical binding]; other site 1205676004562 product (indole) binding pocket [chemical binding]; other site 1205676004563 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1205676004564 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1205676004565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676004566 catalytic residue [active] 1205676004567 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1205676004568 substrate binding site [chemical binding]; other site 1205676004569 active site 1205676004570 catalytic residues [active] 1205676004571 heterodimer interface [polypeptide binding]; other site 1205676004572 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1205676004573 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1205676004574 TM2 domain; Region: TM2; pfam05154 1205676004575 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1205676004576 pyruvate kinase; Provisional; Region: PRK06247 1205676004577 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1205676004578 domain interfaces; other site 1205676004579 active site 1205676004580 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1205676004581 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1205676004582 active site 1205676004583 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1205676004584 catalytic triad [active] 1205676004585 dimer interface [polypeptide binding]; other site 1205676004586 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1205676004587 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1205676004588 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1205676004589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205676004590 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1205676004591 Walker A/P-loop; other site 1205676004592 Walker A/P-loop; other site 1205676004593 ATP binding site [chemical binding]; other site 1205676004594 ATP binding site [chemical binding]; other site 1205676004595 Q-loop/lid; other site 1205676004596 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1205676004597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205676004598 Walker A/P-loop; other site 1205676004599 ATP binding site [chemical binding]; other site 1205676004600 Q-loop/lid; other site 1205676004601 ABC transporter signature motif; other site 1205676004602 Walker B; other site 1205676004603 D-loop; other site 1205676004604 H-loop/switch region; other site 1205676004605 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1205676004606 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1205676004607 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1205676004608 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1205676004609 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1205676004610 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1205676004611 cyclase homology domain; Region: CHD; cd07302 1205676004612 nucleotidyl binding site; other site 1205676004613 metal binding site [ion binding]; metal-binding site 1205676004614 dimer interface [polypeptide binding]; other site 1205676004615 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1205676004616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205676004617 active site 1205676004618 phosphorylation site [posttranslational modification] 1205676004619 intermolecular recognition site; other site 1205676004620 dimerization interface [polypeptide binding]; other site 1205676004621 ANTAR domain; Region: ANTAR; pfam03861 1205676004622 lipid-transfer protein; Provisional; Region: PRK06059 1205676004623 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205676004624 active site 1205676004625 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1205676004626 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1205676004627 DUF35 OB-fold domain; Region: DUF35; pfam01796 1205676004628 DNA polymerase I; Provisional; Region: PRK05755 1205676004629 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1205676004630 active site 1205676004631 metal binding site 1 [ion binding]; metal-binding site 1205676004632 putative 5' ssDNA interaction site; other site 1205676004633 metal binding site 3; metal-binding site 1205676004634 metal binding site 2 [ion binding]; metal-binding site 1205676004635 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1205676004636 putative DNA binding site [nucleotide binding]; other site 1205676004637 putative metal binding site [ion binding]; other site 1205676004638 3'-5' exonuclease; Region: 35EXOc; smart00474 1205676004639 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1205676004640 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1205676004641 active site 1205676004642 DNA binding site [nucleotide binding] 1205676004643 catalytic site [active] 1205676004644 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1205676004645 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1205676004646 RNA binding site [nucleotide binding]; other site 1205676004647 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1205676004648 RNA binding site [nucleotide binding]; other site 1205676004649 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1205676004650 RNA binding site [nucleotide binding]; other site 1205676004651 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1205676004652 RNA binding site [nucleotide binding]; other site 1205676004653 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1205676004654 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1205676004655 CoA-binding site [chemical binding]; other site 1205676004656 ATP-binding [chemical binding]; other site 1205676004657 Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320 1205676004658 Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306 1205676004659 excinuclease ABC subunit B; Provisional; Region: PRK05298 1205676004660 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205676004661 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205676004662 nucleotide binding region [chemical binding]; other site 1205676004663 ATP-binding site [chemical binding]; other site 1205676004664 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1205676004665 UvrB/uvrC motif; Region: UVR; pfam02151 1205676004666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676004667 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205676004668 putative substrate translocation pore; other site 1205676004669 Predicted membrane protein [Function unknown]; Region: COG5305 1205676004670 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205676004671 Ligand Binding Site [chemical binding]; other site 1205676004672 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205676004673 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1205676004674 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1205676004675 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1205676004676 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1205676004677 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1205676004678 Predicted esterase [General function prediction only]; Region: COG0627 1205676004679 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1205676004680 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1205676004681 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1205676004682 dimer interface [polypeptide binding]; other site 1205676004683 putative anticodon binding site; other site 1205676004684 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205676004685 motif 1; other site 1205676004686 dimer interface [polypeptide binding]; other site 1205676004687 active site 1205676004688 motif 2; other site 1205676004689 motif 3; other site 1205676004690 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1205676004691 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1205676004692 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1205676004693 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1205676004694 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1205676004695 23S rRNA binding site [nucleotide binding]; other site 1205676004696 L21 binding site [polypeptide binding]; other site 1205676004697 L13 binding site [polypeptide binding]; other site 1205676004698 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1205676004699 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205676004700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1205676004701 PE family; Region: PE; pfam00934 1205676004702 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205676004703 cyclase homology domain; Region: CHD; cd07302 1205676004704 nucleotidyl binding site; other site 1205676004705 metal binding site [ion binding]; metal-binding site 1205676004706 dimer interface [polypeptide binding]; other site 1205676004707 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1205676004708 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1205676004709 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1205676004710 dimer interface [polypeptide binding]; other site 1205676004711 motif 1; other site 1205676004712 active site 1205676004713 motif 2; other site 1205676004714 motif 3; other site 1205676004715 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1205676004716 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1205676004717 putative tRNA-binding site [nucleotide binding]; other site 1205676004718 B3/4 domain; Region: B3_4; pfam03483 1205676004719 tRNA synthetase B5 domain; Region: B5; smart00874 1205676004720 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1205676004721 dimer interface [polypeptide binding]; other site 1205676004722 motif 1; other site 1205676004723 motif 3; other site 1205676004724 motif 2; other site 1205676004725 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1205676004726 PE family; Region: PE; pfam00934 1205676004727 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1205676004728 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1205676004729 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1205676004730 heterotetramer interface [polypeptide binding]; other site 1205676004731 active site pocket [active] 1205676004732 cleavage site 1205676004733 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1205676004734 feedback inhibition sensing region; other site 1205676004735 homohexameric interface [polypeptide binding]; other site 1205676004736 nucleotide binding site [chemical binding]; other site 1205676004737 N-acetyl-L-glutamate binding site [chemical binding]; other site 1205676004738 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1205676004739 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205676004740 inhibitor-cofactor binding pocket; inhibition site 1205676004741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676004742 catalytic residue [active] 1205676004743 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1205676004744 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1205676004745 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1205676004746 arginine repressor; Provisional; Region: PRK03341 1205676004747 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1205676004748 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1205676004749 argininosuccinate synthase; Provisional; Region: PRK13820 1205676004750 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1205676004751 ANP binding site [chemical binding]; other site 1205676004752 Substrate Binding Site II [chemical binding]; other site 1205676004753 Substrate Binding Site I [chemical binding]; other site 1205676004754 argininosuccinate lyase; Provisional; Region: PRK00855 1205676004755 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1205676004756 active sites [active] 1205676004757 tetramer interface [polypeptide binding]; other site 1205676004758 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1205676004759 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1205676004760 malonyl-CoA binding site [chemical binding]; other site 1205676004761 dimer interface [polypeptide binding]; other site 1205676004762 active site 1205676004763 product binding site; other site 1205676004764 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205676004765 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676004766 active site 1205676004767 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205676004768 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205676004769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676004770 Enoylreductase; Region: PKS_ER; smart00829 1205676004771 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205676004772 NAD(P) binding site [chemical binding]; other site 1205676004773 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1205676004774 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205676004775 putative NADP binding site [chemical binding]; other site 1205676004776 active site 1205676004777 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676004778 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205676004779 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676004780 active site 1205676004781 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205676004782 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205676004783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676004784 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205676004785 Enoylreductase; Region: PKS_ER; smart00829 1205676004786 NAD(P) binding site [chemical binding]; other site 1205676004787 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1205676004788 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205676004789 putative NADP binding site [chemical binding]; other site 1205676004790 active site 1205676004791 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676004792 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205676004793 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676004794 active site 1205676004795 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205676004796 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205676004797 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676004798 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1205676004799 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1205676004800 malonyl-CoA binding site [chemical binding]; other site 1205676004801 dimer interface [polypeptide binding]; other site 1205676004802 active site 1205676004803 product binding site; other site 1205676004804 Cytochrome P450; Region: p450; cl12078 1205676004805 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676004806 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1205676004807 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205676004808 ABC transporter; Region: ABC_tran_2; pfam12848 1205676004809 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205676004810 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1205676004811 MULE transposase domain; Region: MULE; pfam10551 1205676004812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1205676004813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676004814 putative substrate translocation pore; other site 1205676004815 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205676004816 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1205676004817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205676004818 dimerization interface [polypeptide binding]; other site 1205676004819 putative DNA binding site [nucleotide binding]; other site 1205676004820 putative Zn2+ binding site [ion binding]; other site 1205676004821 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1205676004822 active site residue [active] 1205676004823 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205676004824 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205676004825 ligand binding site [chemical binding]; other site 1205676004826 flexible hinge region; other site 1205676004827 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1205676004828 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1205676004829 putative catalytic residues [active] 1205676004830 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1205676004831 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205676004832 catalytic residues [active] 1205676004833 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676004834 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676004835 active site 1205676004836 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1205676004837 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1205676004838 substrate binding pocket [chemical binding]; other site 1205676004839 membrane-bound complex binding site; other site 1205676004840 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1205676004841 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205676004842 FeS/SAM binding site; other site 1205676004843 DivIVA protein; Region: DivIVA; pfam05103 1205676004844 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1205676004845 acyl-CoA synthetase; Validated; Region: PRK07868 1205676004846 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1205676004847 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676004848 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676004849 acyl-activating enzyme (AAE) consensus motif; other site 1205676004850 AMP binding site [chemical binding]; other site 1205676004851 active site 1205676004852 CoA binding site [chemical binding]; other site 1205676004853 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1205676004854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676004855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676004856 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1205676004857 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1205676004858 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205676004859 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1205676004860 Walker A/P-loop; other site 1205676004861 ATP binding site [chemical binding]; other site 1205676004862 Q-loop/lid; other site 1205676004863 ABC transporter signature motif; other site 1205676004864 Walker B; other site 1205676004865 D-loop; other site 1205676004866 H-loop/switch region; other site 1205676004867 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1205676004868 active site 1205676004869 DNA binding site [nucleotide binding] 1205676004870 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1205676004871 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1205676004872 active site 1205676004873 HIGH motif; other site 1205676004874 dimer interface [polypeptide binding]; other site 1205676004875 KMSKS motif; other site 1205676004876 S4 RNA-binding domain; Region: S4; smart00363 1205676004877 RNA binding surface [nucleotide binding]; other site 1205676004878 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205676004879 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1205676004880 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1205676004881 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1205676004882 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1205676004883 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1205676004884 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1205676004885 RNA binding surface [nucleotide binding]; other site 1205676004886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676004887 S-adenosylmethionine binding site [chemical binding]; other site 1205676004888 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1205676004889 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1205676004890 DNA repair protein RecN; Region: recN; TIGR00634 1205676004891 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1205676004892 Walker A/P-loop; other site 1205676004893 ATP binding site [chemical binding]; other site 1205676004894 Q-loop/lid; other site 1205676004895 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1205676004896 ABC transporter signature motif; other site 1205676004897 Walker B; other site 1205676004898 D-loop; other site 1205676004899 H-loop/switch region; other site 1205676004900 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1205676004901 Thiamine pyrophosphokinase; Region: TPK; cl08415 1205676004902 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1205676004903 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1205676004904 CTP synthetase; Validated; Region: pyrG; PRK05380 1205676004905 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1205676004906 Catalytic site [active] 1205676004907 active site 1205676004908 UTP binding site [chemical binding]; other site 1205676004909 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1205676004910 active site 1205676004911 putative oxyanion hole; other site 1205676004912 catalytic triad [active] 1205676004913 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1205676004914 dimer interface [polypeptide binding]; other site 1205676004915 ADP-ribose binding site [chemical binding]; other site 1205676004916 active site 1205676004917 nudix motif; other site 1205676004918 metal binding site [ion binding]; metal-binding site 1205676004919 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1205676004920 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205676004921 active site 1205676004922 DNA binding site [nucleotide binding] 1205676004923 Int/Topo IB signature motif; other site 1205676004924 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12029045, 12657046, 12775759 1205676004925 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12029045, 12657046, 12775759 1205676004926 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1205676004927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676004928 S-adenosylmethionine binding site [chemical binding]; other site 1205676004929 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1205676004930 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676004931 PPE family; Region: PPE; pfam00823 1205676004932 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676004933 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676004934 PPE family; Region: PPE; pfam00823 1205676004935 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676004936 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1205676004937 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1205676004938 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1205676004939 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1205676004940 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205676004941 P-loop; other site 1205676004942 Magnesium ion binding site [ion binding]; other site 1205676004943 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205676004944 Magnesium ion binding site [ion binding]; other site 1205676004945 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1205676004946 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1205676004947 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1205676004948 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1205676004949 RNA binding surface [nucleotide binding]; other site 1205676004950 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1205676004951 active site 1205676004952 cytidylate kinase; Provisional; Region: cmk; PRK00023 1205676004953 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1205676004954 CMP-binding site; other site 1205676004955 The sites determining sugar specificity; other site 1205676004956 GTP-binding protein Der; Reviewed; Region: PRK03003 1205676004957 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1205676004958 GTP/Mg2+ binding site [chemical binding]; other site 1205676004959 Switch I region; other site 1205676004960 G2 box; other site 1205676004961 Switch II region; other site 1205676004962 G3 box; other site 1205676004963 G4 box; other site 1205676004964 G5 box; other site 1205676004965 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1205676004966 G1 box; other site 1205676004967 GTP/Mg2+ binding site [chemical binding]; other site 1205676004968 Switch I region; other site 1205676004969 G2 box; other site 1205676004970 G3 box; other site 1205676004971 Switch II region; other site 1205676004972 G4 box; other site 1205676004973 G5 box; other site 1205676004974 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1205676004975 classical (c) SDRs; Region: SDR_c; cd05233 1205676004976 NAD(P) binding site [chemical binding]; other site 1205676004977 active site 1205676004978 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1205676004979 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1205676004980 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1205676004981 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1205676004982 Cupin domain; Region: Cupin_2; pfam07883 1205676004983 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1205676004984 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205676004985 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1205676004986 putative switch regulator; other site 1205676004987 non-specific DNA interactions [nucleotide binding]; other site 1205676004988 DNA binding site [nucleotide binding] 1205676004989 sequence specific DNA binding site [nucleotide binding]; other site 1205676004990 putative cAMP binding site [chemical binding]; other site 1205676004991 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205676004992 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 1205676004993 putative active site [active] 1205676004994 homotetrameric interface [polypeptide binding]; other site 1205676004995 metal binding site [ion binding]; metal-binding site 1205676004996 biotin carboxylase-like protein; Validated; Region: PRK06524 1205676004997 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1205676004998 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205676004999 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205676005000 Predicted transcriptional regulators [Transcription]; Region: COG1733 1205676005001 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205676005002 dimerization interface [polypeptide binding]; other site 1205676005003 putative DNA binding site [nucleotide binding]; other site 1205676005004 putative Zn2+ binding site [ion binding]; other site 1205676005005 Predicted transcriptional regulators [Transcription]; Region: COG1733 1205676005006 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205676005007 FAD binding domain; Region: FAD_binding_4; pfam01565 1205676005008 Berberine and berberine like; Region: BBE; pfam08031 1205676005009 TIGR03086 family protein; Region: TIGR03086 1205676005010 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205676005011 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205676005012 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205676005013 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205676005014 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205676005015 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1205676005016 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1205676005017 NAD(P) binding site [chemical binding]; other site 1205676005018 catalytic residues [active] 1205676005019 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1205676005020 putative catalytic residue [active] 1205676005021 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1205676005022 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205676005023 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1205676005024 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1205676005025 gating phenylalanine in ion channel; other site 1205676005026 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1205676005027 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1205676005028 nitrate reductase, beta subunit; Region: narH; TIGR01660 1205676005029 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1205676005030 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1205676005031 [4Fe-4S] binding site [ion binding]; other site 1205676005032 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205676005033 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205676005034 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205676005035 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1205676005036 molybdopterin cofactor binding site; other site 1205676005037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676005038 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1205676005039 putative substrate translocation pore; other site 1205676005040 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1205676005041 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1205676005042 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1205676005043 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1205676005044 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1205676005045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1205676005046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 1205676005047 putative active site [active] 1205676005048 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1205676005049 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205676005050 active site 1205676005051 ATP binding site [chemical binding]; other site 1205676005052 substrate binding site [chemical binding]; other site 1205676005053 activation loop (A-loop); other site 1205676005054 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1205676005055 Thioredoxin; Region: Thioredoxin_4; cl17273 1205676005056 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1205676005057 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1205676005058 active site 1205676005059 metal binding site [ion binding]; metal-binding site 1205676005060 nudix motif; other site 1205676005061 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205676005062 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205676005063 active site 1205676005064 ATP binding site [chemical binding]; other site 1205676005065 substrate binding site [chemical binding]; other site 1205676005066 activation loop (A-loop); other site 1205676005067 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205676005068 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205676005069 phosphopeptide binding site; other site 1205676005070 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205676005071 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205676005072 phosphopeptide binding site; other site 1205676005073 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1205676005074 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 1205676005075 Walker A/P-loop; other site 1205676005076 ATP binding site [chemical binding]; other site 1205676005077 Q-loop/lid; other site 1205676005078 ABC transporter signature motif; other site 1205676005079 Walker B; other site 1205676005080 D-loop; other site 1205676005081 H-loop/switch region; other site 1205676005082 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1205676005083 acyl-CoA synthetase; Provisional; Region: PRK13388 1205676005084 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676005085 acyl-activating enzyme (AAE) consensus motif; other site 1205676005086 AMP binding site [chemical binding]; other site 1205676005087 active site 1205676005088 CoA binding site [chemical binding]; other site 1205676005089 hypothetical protein; Provisional; Region: PRK06185 1205676005090 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205676005091 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1205676005092 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1205676005093 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 12775759 1205676005094 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 12775759 1205676005095 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1205676005096 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1205676005097 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1205676005098 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205676005099 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1205676005100 sulfite oxidase; Provisional; Region: PLN00177 1205676005101 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1205676005102 Moco binding site; other site 1205676005103 metal coordination site [ion binding]; other site 1205676005104 dimerization interface [polypeptide binding]; other site 1205676005105 Transport protein; Region: actII; TIGR00833 1205676005106 Cutinase; Region: Cutinase; pfam01083 1205676005107 PE family; Region: PE; pfam00934 1205676005108 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205676005109 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205676005110 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15024109, 15525680 1205676005111 HTH-like domain; Region: HTH_21; pfam13276 1205676005112 Integrase core domain; Region: rve; pfam00665 1205676005113 Integrase core domain; Region: rve_3; pfam13683 1205676005114 Transposase; Region: HTH_Tnp_1; pfam01527 1205676005115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205676005116 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15024109, 15525680 1205676005117 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205676005118 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205676005119 active site 1205676005120 Integrase core domain; Region: rve; pfam00665 1205676005121 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1205676005122 putative homotetramer interface [polypeptide binding]; other site 1205676005123 putative homodimer interface [polypeptide binding]; other site 1205676005124 putative allosteric switch controlling residues; other site 1205676005125 putative metal binding site [ion binding]; other site 1205676005126 putative homodimer-homodimer interface [polypeptide binding]; other site 1205676005127 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1205676005128 PE family; Region: PE; pfam00934 1205676005129 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1205676005130 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1205676005131 dimer interface [polypeptide binding]; other site 1205676005132 active site 1205676005133 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205676005134 substrate binding site [chemical binding]; other site 1205676005135 catalytic residue [active] 1205676005136 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1205676005137 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1205676005138 metal binding site [ion binding]; metal-binding site 1205676005139 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1205676005140 FAD binding domain; Region: FAD_binding_4; pfam01565 1205676005141 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1205676005142 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1205676005143 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205676005144 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205676005145 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205676005146 FAD binding domain; Region: FAD_binding_4; pfam01565 1205676005147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676005148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676005149 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676005150 Cytochrome P450; Region: p450; cl12078 1205676005151 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1205676005152 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1205676005153 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1205676005154 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1205676005155 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1205676005156 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205676005157 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205676005158 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205676005159 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676005160 Cytochrome P450; Region: p450; cl12078 1205676005161 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1205676005162 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676005163 PPE family; Region: PPE; pfam00823 1205676005164 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676005165 PE family; Region: PE; pfam00934 1205676005166 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676005167 PPE family; Region: PPE; pfam00823 1205676005168 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676005169 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676005170 PPE family; Region: PPE; pfam00823 1205676005171 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676005172 PE family; Region: PE; pfam00934 1205676005173 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1205676005174 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205676005175 EspG family; Region: ESX-1_EspG; pfam14011 1205676005176 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1205676005177 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205676005178 catalytic residues [active] 1205676005179 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1205676005180 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1205676005181 active site 1205676005182 catalytic residues [active] 1205676005183 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1205676005184 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1205676005185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676005186 Walker A motif; other site 1205676005187 ATP binding site [chemical binding]; other site 1205676005188 Walker B motif; other site 1205676005189 arginine finger; other site 1205676005190 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676005191 PPE family; Region: PPE; pfam00823 1205676005192 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676005193 PPE family; Region: PPE; pfam00823 1205676005194 PE family; Region: PE; pfam00934 1205676005195 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205676005196 PE family; Region: PE; pfam00934 1205676005197 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676005198 PPE family; Region: PPE; pfam00823 1205676005199 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676005200 PPE family; Region: PPE; pfam00823 1205676005201 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676005202 PPE family; Region: PPE; pfam00823 1205676005203 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676005204 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205676005205 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1205676005206 MgtC family; Region: MgtC; pfam02308 1205676005207 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1205676005208 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205676005209 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1205676005210 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1205676005211 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1205676005212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676005213 hypothetical protein; Validated; Region: PRK07121 1205676005214 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1205676005215 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 1205676005216 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1205676005217 hypothetical protein; Provisional; Region: PRK05858 1205676005218 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205676005219 PYR/PP interface [polypeptide binding]; other site 1205676005220 dimer interface [polypeptide binding]; other site 1205676005221 TPP binding site [chemical binding]; other site 1205676005222 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205676005223 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1205676005224 TPP-binding site; other site 1205676005225 dimer interface [polypeptide binding]; other site 1205676005226 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1205676005227 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1205676005228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1205676005229 nucleotide binding region [chemical binding]; other site 1205676005230 ATP-binding site [chemical binding]; other site 1205676005231 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1205676005232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1205676005233 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1205676005234 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 1205676005235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1205676005236 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1205676005237 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1205676005238 lipoyl attachment site [posttranslational modification]; other site 1205676005239 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205676005240 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205676005241 phosphopeptide binding site; other site 1205676005242 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1205676005243 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205676005244 DNA binding residues [nucleotide binding] 1205676005245 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1205676005246 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1205676005247 DNA binding residues [nucleotide binding] 1205676005248 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1205676005249 putative dimer interface [polypeptide binding]; other site 1205676005250 glycine dehydrogenase; Provisional; Region: PRK05367 1205676005251 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1205676005252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676005253 tetramer interface [polypeptide binding]; other site 1205676005254 catalytic residue [active] 1205676005255 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1205676005256 tetramer interface [polypeptide binding]; other site 1205676005257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676005258 catalytic residue [active] 1205676005259 haloalkane dehalogenase; Provisional; Region: PRK03204 1205676005260 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205676005261 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 1205676005262 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1205676005263 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1205676005264 metal ion-dependent adhesion site (MIDAS); other site 1205676005265 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1205676005266 active site 1205676005267 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205676005268 putative active site [active] 1205676005269 Domain of unknown function DUF21; Region: DUF21; pfam01595 1205676005270 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1205676005271 FOG: CBS domain [General function prediction only]; Region: COG0517 1205676005272 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1205676005273 Domain of unknown function DUF21; Region: DUF21; pfam01595 1205676005274 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1205676005275 Transporter associated domain; Region: CorC_HlyC; smart01091 1205676005276 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1205676005277 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205676005278 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1205676005279 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1205676005280 active site 1205676005281 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1205676005282 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1205676005283 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1205676005284 Peptidase family M48; Region: Peptidase_M48; cl12018 1205676005285 Predicted transcriptional regulator [Transcription]; Region: COG3682 1205676005286 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1205676005287 CoenzymeA binding site [chemical binding]; other site 1205676005288 subunit interaction site [polypeptide binding]; other site 1205676005289 PHB binding site; other site 1205676005290 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1205676005291 alpha-gamma subunit interface [polypeptide binding]; other site 1205676005292 beta-gamma subunit interface [polypeptide binding]; other site 1205676005293 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1205676005294 gamma-beta subunit interface [polypeptide binding]; other site 1205676005295 alpha-beta subunit interface [polypeptide binding]; other site 1205676005296 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1205676005297 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1205676005298 subunit interactions [polypeptide binding]; other site 1205676005299 active site 1205676005300 flap region; other site 1205676005301 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1205676005302 UreF; Region: UreF; pfam01730 1205676005303 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205676005304 UreD urease accessory protein; Region: UreD; cl00530 1205676005305 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1205676005306 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205676005307 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1205676005308 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205676005309 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205676005310 classical (c) SDRs; Region: SDR_c; cd05233 1205676005311 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1205676005312 NAD(P) binding site [chemical binding]; other site 1205676005313 active site 1205676005314 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1205676005315 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1205676005316 sulfate transport protein; Provisional; Region: cysT; CHL00187 1205676005317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676005318 dimer interface [polypeptide binding]; other site 1205676005319 conserved gate region; other site 1205676005320 putative PBP binding loops; other site 1205676005321 ABC-ATPase subunit interface; other site 1205676005322 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1205676005323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205676005324 Walker A/P-loop; other site 1205676005325 ATP binding site [chemical binding]; other site 1205676005326 Q-loop/lid; other site 1205676005327 ABC transporter signature motif; other site 1205676005328 Walker B; other site 1205676005329 D-loop; other site 1205676005330 H-loop/switch region; other site 1205676005331 TOBE domain; Region: TOBE; pfam03459 1205676005332 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1205676005333 Predicted membrane protein [Function unknown]; Region: COG2261 1205676005334 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1205676005335 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1205676005336 putative NAD(P) binding site [chemical binding]; other site 1205676005337 putative substrate binding site [chemical binding]; other site 1205676005338 catalytic Zn binding site [ion binding]; other site 1205676005339 structural Zn binding site [ion binding]; other site 1205676005340 CAAX protease self-immunity; Region: Abi; pfam02517 1205676005341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1205676005342 MOSC domain; Region: MOSC; pfam03473 1205676005343 short chain dehydrogenase; Provisional; Region: PRK07825 1205676005344 classical (c) SDRs; Region: SDR_c; cd05233 1205676005345 NAD(P) binding site [chemical binding]; other site 1205676005346 active site 1205676005347 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205676005348 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205676005349 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205676005350 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205676005351 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1205676005352 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205676005353 active site 1205676005354 hypothetical protein; Provisional; Region: PRK12320 1205676005355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676005356 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1205676005357 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205676005358 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205676005359 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205676005360 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1205676005361 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1205676005362 active site 1205676005363 substrate binding site [chemical binding]; other site 1205676005364 FMN binding site [chemical binding]; other site 1205676005365 putative catalytic residues [active] 1205676005366 Uncharacterized conserved protein [Function unknown]; Region: COG5579 1205676005367 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1205676005368 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1205676005369 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1205676005370 heme binding site [chemical binding]; other site 1205676005371 ferroxidase pore; other site 1205676005372 ferroxidase diiron center [ion binding]; other site 1205676005373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676005374 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205676005375 putative substrate translocation pore; other site 1205676005376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676005377 putative substrate translocation pore; other site 1205676005378 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333 1205676005379 23S rRNA interface [nucleotide binding]; other site 1205676005380 L3 interface [polypeptide binding]; other site 1205676005381 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205676005382 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1205676005383 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1205676005384 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1205676005385 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676005386 Cytochrome P450; Region: p450; cl12078 1205676005387 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1205676005388 short chain dehydrogenase; Provisional; Region: PRK08267 1205676005389 classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931 1205676005390 putative NAD(P) binding site [chemical binding]; other site 1205676005391 active site 1205676005392 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1205676005393 hydrophobic ligand binding site; other site 1205676005394 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1205676005395 chorismate mutase; Provisional; Region: PRK09269 1205676005396 chorismate mutase, putative; Region: CM_mono2; TIGR01806 1205676005397 Putative esterase; Region: Esterase; pfam00756 1205676005398 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1205676005399 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205676005400 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1205676005401 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1205676005402 Nitronate monooxygenase; Region: NMO; pfam03060 1205676005403 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1205676005404 FMN binding site [chemical binding]; other site 1205676005405 substrate binding site [chemical binding]; other site 1205676005406 putative catalytic residue [active] 1205676005407 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 1205676005408 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1205676005409 catalytic Zn binding site [ion binding]; other site 1205676005410 NAD(P) binding site [chemical binding]; other site 1205676005411 structural Zn binding site [ion binding]; other site 1205676005412 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205676005413 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205676005414 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1205676005415 putative active site [active] 1205676005416 dimerization interface [polypeptide binding]; other site 1205676005417 putative tRNAtyr binding site [nucleotide binding]; other site 1205676005418 Domain of unknown function DUF77; Region: DUF77; pfam01910 1205676005419 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 1205676005420 putative ADP-ribose binding site [chemical binding]; other site 1205676005421 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676005422 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205676005423 cyclase homology domain; Region: CHD; cd07302 1205676005424 nucleotidyl binding site; other site 1205676005425 metal binding site [ion binding]; metal-binding site 1205676005426 dimer interface [polypeptide binding]; other site 1205676005427 competence damage-inducible protein A; Provisional; Region: PRK00549 1205676005428 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1205676005429 putative MPT binding site; other site 1205676005430 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1205676005431 putative sialic acid transporter; Region: 2A0112; TIGR00891 1205676005432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676005433 putative substrate translocation pore; other site 1205676005434 Predicted membrane protein [Function unknown]; Region: COG1950 1205676005435 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205676005436 anti sigma factor interaction site; other site 1205676005437 regulatory phosphorylation site [posttranslational modification]; other site 1205676005438 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1205676005439 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1205676005440 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1205676005441 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1205676005442 dimer interface [polypeptide binding]; other site 1205676005443 active site 1205676005444 heme binding site [chemical binding]; other site 1205676005445 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1205676005446 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1205676005447 metal binding site 2 [ion binding]; metal-binding site 1205676005448 putative DNA binding helix; other site 1205676005449 metal binding site 1 [ion binding]; metal-binding site 1205676005450 dimer interface [polypeptide binding]; other site 1205676005451 structural Zn2+ binding site [ion binding]; other site 1205676005452 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1205676005453 substrate binding site [chemical binding]; other site 1205676005454 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1205676005455 substrate binding site [chemical binding]; other site 1205676005456 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205676005457 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 1205676005458 putative NAD(P) binding site [chemical binding]; other site 1205676005459 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205676005460 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1205676005461 tetramer interface [polypeptide binding]; other site 1205676005462 active site 1205676005463 Mg2+/Mn2+ binding site [ion binding]; other site 1205676005464 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1205676005465 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676005466 PPE family; Region: PPE; pfam00823 1205676005467 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676005468 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676005469 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676005470 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676005471 PPE family; Region: PPE; pfam00823 1205676005472 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676005473 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676005474 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1205676005475 putative hydrophobic ligand binding site [chemical binding]; other site 1205676005476 protein interface [polypeptide binding]; other site 1205676005477 gate; other site 1205676005478 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205676005479 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1205676005480 putative acyl-acceptor binding pocket; other site 1205676005481 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1205676005482 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205676005483 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205676005484 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205676005485 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205676005486 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1205676005487 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205676005488 acyl-activating enzyme (AAE) consensus motif; other site 1205676005489 active site 1205676005490 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1205676005491 Uncharacterized conserved protein [Function unknown]; Region: COG3361 1205676005492 short chain dehydrogenase; Provisional; Region: PRK05867 1205676005493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676005494 NAD(P) binding site [chemical binding]; other site 1205676005495 active site 1205676005496 TIGR03085 family protein; Region: TIGR03085 1205676005497 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1205676005498 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1205676005499 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1205676005500 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1205676005501 conserved cys residue [active] 1205676005502 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205676005503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205676005504 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1205676005505 dimer interface [polypeptide binding]; other site 1205676005506 catalytic triad [active] 1205676005507 peroxidatic and resolving cysteines [active] 1205676005508 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676005509 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205676005510 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1205676005511 active site 1205676005512 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676005513 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1205676005514 FAD binding site [chemical binding]; other site 1205676005515 substrate binding site [chemical binding]; other site 1205676005516 catalytic base [active] 1205676005517 enoyl-CoA hydratase; Provisional; Region: PRK08290 1205676005518 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676005519 substrate binding site [chemical binding]; other site 1205676005520 oxyanion hole (OAH) forming residues; other site 1205676005521 trimer interface [polypeptide binding]; other site 1205676005522 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205676005523 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1205676005524 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1205676005525 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205676005526 catalytic loop [active] 1205676005527 iron binding site [ion binding]; other site 1205676005528 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1205676005529 FAD binding pocket [chemical binding]; other site 1205676005530 FAD binding motif [chemical binding]; other site 1205676005531 phosphate binding motif [ion binding]; other site 1205676005532 beta-alpha-beta structure motif; other site 1205676005533 NAD binding pocket [chemical binding]; other site 1205676005534 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205676005535 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1205676005536 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676005537 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1205676005538 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1205676005539 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1205676005540 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 1205676005541 dimerization interface [polypeptide binding]; other site 1205676005542 active site 1205676005543 classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944 1205676005544 putative NAD(P) binding site [chemical binding]; other site 1205676005545 active site 1205676005546 homodimer interface [polypeptide binding]; other site 1205676005547 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205676005548 SEC-C motif; Region: SEC-C; pfam02810 1205676005549 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205676005550 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205676005551 active site 1205676005552 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1205676005553 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1205676005554 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1205676005555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205676005556 non-specific DNA binding site [nucleotide binding]; other site 1205676005557 salt bridge; other site 1205676005558 sequence-specific DNA binding site [nucleotide binding]; other site 1205676005559 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1205676005560 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 1205676005561 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1205676005562 putative active site [active] 1205676005563 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205676005564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676005565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676005566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676005567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676005568 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205676005569 Permease; Region: Permease; pfam02405 1205676005570 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205676005571 Permease; Region: Permease; pfam02405 1205676005572 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676005573 mce related protein; Region: MCE; pfam02470 1205676005574 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205676005575 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676005576 mce related protein; Region: MCE; pfam02470 1205676005577 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676005578 mce related protein; Region: MCE; pfam02470 1205676005579 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676005580 mce related protein; Region: MCE; pfam02470 1205676005581 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676005582 mce related protein; Region: MCE; pfam02470 1205676005583 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676005584 mce related protein; Region: MCE; pfam02470 1205676005585 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205676005586 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1205676005587 YacP-like NYN domain; Region: NYN_YacP; cl01491 1205676005588 PE family; Region: PE; pfam00934 1205676005589 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1205676005590 Peptidase family M48; Region: Peptidase_M48; pfam01435 1205676005591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676005592 S-adenosylmethionine binding site [chemical binding]; other site 1205676005593 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1205676005594 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1205676005595 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1205676005596 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1205676005597 dimer interface [polypeptide binding]; other site 1205676005598 putative radical transfer pathway; other site 1205676005599 diiron center [ion binding]; other site 1205676005600 tyrosyl radical; other site 1205676005601 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1205676005602 putative active site [active] 1205676005603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1205676005604 PE family; Region: PE; pfam00934 1205676005605 Cutinase; Region: Cutinase; pfam01083 1205676005606 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1205676005607 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1205676005608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205676005609 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1205676005610 dimerization interface [polypeptide binding]; other site 1205676005611 Lysine efflux permease [General function prediction only]; Region: COG1279 1205676005612 Cellulose binding domain; Region: CBM_2; pfam00553 1205676005613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676005614 S-adenosylmethionine binding site [chemical binding]; other site 1205676005615 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205676005616 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205676005617 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1205676005618 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205676005619 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1205676005620 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205676005621 dimerization interface [polypeptide binding]; other site 1205676005622 putative DNA binding site [nucleotide binding]; other site 1205676005623 putative Zn2+ binding site [ion binding]; other site 1205676005624 Hemerythrin-like domain; Region: Hr-like; cd12108 1205676005625 Fe binding site [ion binding]; other site 1205676005626 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205676005627 Ligand Binding Site [chemical binding]; other site 1205676005628 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205676005629 Ligand Binding Site [chemical binding]; other site 1205676005630 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1205676005631 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1205676005632 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205676005633 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1205676005634 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205676005635 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1205676005636 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1205676005637 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1205676005638 tetramer interface [polypeptide binding]; other site 1205676005639 active site 1205676005640 Mg2+/Mn2+ binding site [ion binding]; other site 1205676005641 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1205676005642 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205676005643 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1205676005644 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1205676005645 homotetramer interface [polypeptide binding]; other site 1205676005646 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1205676005647 NAD binding site [chemical binding]; other site 1205676005648 homodimer interface [polypeptide binding]; other site 1205676005649 active site 1205676005650 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205676005651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676005652 S-adenosylmethionine binding site [chemical binding]; other site 1205676005653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1205676005654 Predicted kinase [General function prediction only]; Region: COG0645 1205676005655 AAA domain; Region: AAA_17; pfam13207 1205676005656 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205676005657 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205676005658 Ligand Binding Site [chemical binding]; other site 1205676005659 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1205676005660 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1205676005661 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1205676005662 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1205676005663 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1205676005664 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1205676005665 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1205676005666 Ferredoxin [Energy production and conversion]; Region: COG1146 1205676005667 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1205676005668 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1205676005669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676005670 Walker A motif; other site 1205676005671 ATP binding site [chemical binding]; other site 1205676005672 Walker B motif; other site 1205676005673 arginine finger; other site 1205676005674 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205676005675 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205676005676 putative active site [active] 1205676005677 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1205676005678 MarR family; Region: MarR_2; pfam12802 1205676005679 Phage envelope protein [General function prediction only]; Region: COG5562 1205676005680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205676005681 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205676005682 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205676005683 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205676005684 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205676005685 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205676005686 active site 1205676005687 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046 1205676005688 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205676005689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205676005690 non-specific DNA binding site [nucleotide binding]; other site 1205676005691 salt bridge; other site 1205676005692 sequence-specific DNA binding site [nucleotide binding]; other site 1205676005693 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1205676005694 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1205676005695 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205676005696 non-specific DNA binding site [nucleotide binding]; other site 1205676005697 salt bridge; other site 1205676005698 sequence-specific DNA binding site [nucleotide binding]; other site 1205676005699 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1205676005700 AAA domain; Region: AAA_21; pfam13304 1205676005701 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1205676005702 active site 1205676005703 metal binding site [ion binding]; metal-binding site 1205676005704 Family description; Region: UvrD_C_2; pfam13538 1205676005705 Predicted helicase [General function prediction only]; Region: COG4889 1205676005706 Predicted helicase [General function prediction only]; Region: COG4889 1205676005707 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1205676005708 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1205676005709 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205676005710 ATP binding site [chemical binding]; other site 1205676005711 putative Mg++ binding site [ion binding]; other site 1205676005712 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1205676005713 ATP-binding site [chemical binding]; other site 1205676005714 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1205676005715 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1205676005716 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1205676005717 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205676005718 Ligand Binding Site [chemical binding]; other site 1205676005719 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205676005720 Ligand Binding Site [chemical binding]; other site 1205676005721 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1205676005722 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1205676005723 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205676005724 Histidine kinase; Region: HisKA_3; pfam07730 1205676005725 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205676005726 Ligand Binding Site [chemical binding]; other site 1205676005727 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1205676005728 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1205676005729 putative substrate binding site [chemical binding]; other site 1205676005730 putative ATP binding site [chemical binding]; other site 1205676005731 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205676005732 active site 1205676005733 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1205676005734 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1205676005735 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1205676005736 putative dimer interface [polypeptide binding]; other site 1205676005737 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205676005738 dimer interface [polypeptide binding]; other site 1205676005739 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1205676005740 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205676005741 putative DNA binding site [nucleotide binding]; other site 1205676005742 dimerization interface [polypeptide binding]; other site 1205676005743 putative Zn2+ binding site [ion binding]; other site 1205676005744 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1205676005745 putative hydrophobic ligand binding site [chemical binding]; other site 1205676005746 CLM binding site; other site 1205676005747 L1 loop; other site 1205676005748 DNA binding site [nucleotide binding] 1205676005749 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205676005750 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1205676005751 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1205676005752 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1205676005753 nucleophile elbow; other site 1205676005754 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1205676005755 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1205676005756 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1205676005757 Walker A/P-loop; other site 1205676005758 ATP binding site [chemical binding]; other site 1205676005759 Q-loop/lid; other site 1205676005760 ABC transporter signature motif; other site 1205676005761 Walker B; other site 1205676005762 D-loop; other site 1205676005763 H-loop/switch region; other site 1205676005764 TOBE domain; Region: TOBE_2; pfam08402 1205676005765 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205676005766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676005767 dimer interface [polypeptide binding]; other site 1205676005768 conserved gate region; other site 1205676005769 putative PBP binding loops; other site 1205676005770 ABC-ATPase subunit interface; other site 1205676005771 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1205676005772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676005773 dimer interface [polypeptide binding]; other site 1205676005774 conserved gate region; other site 1205676005775 putative PBP binding loops; other site 1205676005776 ABC-ATPase subunit interface; other site 1205676005777 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1205676005778 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1205676005779 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1205676005780 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1205676005781 Isochorismatase family; Region: Isochorismatase; pfam00857 1205676005782 catalytic triad [active] 1205676005783 metal binding site [ion binding]; metal-binding site 1205676005784 conserved cis-peptide bond; other site 1205676005785 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1205676005786 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1205676005787 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205676005788 substrate binding pocket [chemical binding]; other site 1205676005789 catalytic triad [active] 1205676005790 hypothetical protein; Provisional; Region: PRK05865 1205676005791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676005792 NAD(P) binding site [chemical binding]; other site 1205676005793 active site 1205676005794 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1205676005795 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205676005796 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676005797 active site 1205676005798 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205676005799 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205676005800 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676005801 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205676005802 Enoylreductase; Region: PKS_ER; smart00829 1205676005803 NAD(P) binding site [chemical binding]; other site 1205676005804 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1205676005805 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205676005806 putative NADP binding site [chemical binding]; other site 1205676005807 active site 1205676005808 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676005809 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205676005810 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676005811 active site 1205676005812 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205676005813 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205676005814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676005815 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205676005816 Enoylreductase; Region: PKS_ER; smart00829 1205676005817 NAD(P) binding site [chemical binding]; other site 1205676005818 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1205676005819 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205676005820 putative NADP binding site [chemical binding]; other site 1205676005821 active site 1205676005822 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676005823 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1205676005824 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1205676005825 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1205676005826 putative active site [active] 1205676005827 catalytic triad [active] 1205676005828 putative dimer interface [polypeptide binding]; other site 1205676005829 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1205676005830 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1205676005831 Ligand binding site; other site 1205676005832 Putative Catalytic site; other site 1205676005833 DXD motif; other site 1205676005834 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1205676005835 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1205676005836 active site 1205676005837 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1205676005838 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1205676005839 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1205676005840 30S ribosomal protein S18; Provisional; Region: PRK13401 1205676005841 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1205676005842 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1205676005843 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1205676005844 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1205676005845 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1205676005846 intersubunit interface [polypeptide binding]; other site 1205676005847 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1205676005848 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1205676005849 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1205676005850 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1205676005851 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1205676005852 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1205676005853 PemK-like protein; Region: PemK; pfam02452 1205676005854 precorrin-3B synthase; Region: CobG; TIGR02435 1205676005855 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1205676005856 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1205676005857 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1205676005858 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1205676005859 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1205676005860 active site 1205676005861 SAM binding site [chemical binding]; other site 1205676005862 homodimer interface [polypeptide binding]; other site 1205676005863 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1205676005864 active site 1205676005865 SAM binding site [chemical binding]; other site 1205676005866 homodimer interface [polypeptide binding]; other site 1205676005867 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205676005868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676005869 S-adenosylmethionine binding site [chemical binding]; other site 1205676005870 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1205676005871 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1205676005872 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1205676005873 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205676005874 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205676005875 DNA binding residues [nucleotide binding] 1205676005876 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1205676005877 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 1205676005878 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1205676005879 active site 1205676005880 SAM binding site [chemical binding]; other site 1205676005881 homodimer interface [polypeptide binding]; other site 1205676005882 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1205676005883 active site 1205676005884 putative homodimer interface [polypeptide binding]; other site 1205676005885 SAM binding site [chemical binding]; other site 1205676005886 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1205676005887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205676005888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676005889 NAD(P) binding site [chemical binding]; other site 1205676005890 active site 1205676005891 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1205676005892 Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590 1205676005893 putative active site [active] 1205676005894 catalytic site [active] 1205676005895 putative metal binding site [ion binding]; other site 1205676005896 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1205676005897 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1205676005898 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1205676005899 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 12775759 1205676005900 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929527; Product type pe : putative enzyme 1205676005901 Transposase; Region: HTH_Tnp_1; cl17663 1205676005902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205676005903 putative transposase OrfB; Reviewed; Region: PHA02517 1205676005904 HTH-like domain; Region: HTH_21; pfam13276 1205676005905 Integrase core domain; Region: rve; pfam00665 1205676005906 Integrase core domain; Region: rve_3; pfam13683 1205676005907 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929527; Product type pe : putative enzyme 1205676005908 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1205676005909 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1205676005910 Integrase core domain; Region: rve; pfam00665 1205676005911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1205676005912 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1205676005913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676005914 Walker A motif; other site 1205676005915 ATP binding site [chemical binding]; other site 1205676005916 Walker B motif; other site 1205676005917 putative transposase OrfB; Reviewed; Region: PHA02517 1205676005918 HTH-like domain; Region: HTH_21; pfam13276 1205676005919 Integrase core domain; Region: rve; pfam00665 1205676005920 Integrase core domain; Region: rve_3; pfam13683 1205676005921 Transposase; Region: HTH_Tnp_1; cl17663 1205676005922 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205676005923 Integrase core domain; Region: rve; pfam00665 1205676005924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1205676005925 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1205676005926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676005927 Walker A motif; other site 1205676005928 ATP binding site [chemical binding]; other site 1205676005929 Walker B motif; other site 1205676005930 HTH-like domain; Region: HTH_21; pfam13276 1205676005931 Transposase; Region: HTH_Tnp_1; cl17663 1205676005932 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205676005933 putative transposase OrfB; Reviewed; Region: PHA02517 1205676005934 HTH-like domain; Region: HTH_21; pfam13276 1205676005935 Integrase core domain; Region: rve; pfam00665 1205676005936 Integrase core domain; Region: rve_3; pfam13683 1205676005937 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1205676005938 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1205676005939 active site 1205676005940 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 1205676005941 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1205676005942 active site 1205676005943 metal binding site 1 [ion binding]; metal-binding site 1205676005944 putative 5' ssDNA interaction site; other site 1205676005945 metal binding site 3; metal-binding site 1205676005946 metal binding site 2 [ion binding]; metal-binding site 1205676005947 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1205676005948 putative DNA binding site [nucleotide binding]; other site 1205676005949 putative metal binding site [ion binding]; other site 1205676005950 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1205676005951 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1205676005952 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205676005953 ATP binding site [chemical binding]; other site 1205676005954 putative Mg++ binding site [ion binding]; other site 1205676005955 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205676005956 nucleotide binding region [chemical binding]; other site 1205676005957 ATP-binding site [chemical binding]; other site 1205676005958 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1205676005959 Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945 1205676005960 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1205676005961 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1205676005962 Predicted transcriptional regulator [Transcription]; Region: COG2378 1205676005963 WYL domain; Region: WYL; pfam13280 1205676005964 Predicted transcriptional regulator [Transcription]; Region: COG2378 1205676005965 WYL domain; Region: WYL; pfam13280 1205676005966 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1205676005967 PE family; Region: PE; pfam00934 1205676005968 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205676005969 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205676005970 active site 1205676005971 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1205676005972 SNF2 Helicase protein; Region: DUF3670; pfam12419 1205676005973 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205676005974 ATP binding site [chemical binding]; other site 1205676005975 putative Mg++ binding site [ion binding]; other site 1205676005976 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205676005977 nucleotide binding region [chemical binding]; other site 1205676005978 ATP-binding site [chemical binding]; other site 1205676005979 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1205676005980 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205676005981 putative active site [active] 1205676005982 PE family; Region: PE; pfam00934 1205676005983 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676005984 PPE family; Region: PPE; pfam00823 1205676005985 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1205676005986 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1205676005987 active site 1205676005988 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1205676005989 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1205676005990 active site 1205676005991 Pup-like protein; Region: Pup; pfam05639 1205676005992 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1205676005993 proteasome ATPase; Region: pup_AAA; TIGR03689 1205676005994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676005995 Walker A motif; other site 1205676005996 ATP binding site [chemical binding]; other site 1205676005997 Walker B motif; other site 1205676005998 arginine finger; other site 1205676005999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1205676006000 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1205676006001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676006002 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1205676006003 Predicted membrane protein [Function unknown]; Region: COG3918 1205676006004 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1205676006005 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1205676006006 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1205676006007 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1205676006008 homodimer interface [polypeptide binding]; other site 1205676006009 putative metal binding site [ion binding]; other site 1205676006010 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676006011 PPE family; Region: PPE; pfam00823 1205676006012 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1205676006013 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1205676006014 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1205676006015 substrate binding pocket [chemical binding]; other site 1205676006016 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1205676006017 B12 binding site [chemical binding]; other site 1205676006018 cobalt ligand [ion binding]; other site 1205676006019 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1205676006020 PAC2 family; Region: PAC2; pfam09754 1205676006021 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1205676006022 short chain dehydrogenase; Provisional; Region: PRK05872 1205676006023 classical (c) SDRs; Region: SDR_c; cd05233 1205676006024 NAD(P) binding site [chemical binding]; other site 1205676006025 active site 1205676006026 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1205676006027 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1205676006028 active site 1205676006029 HIGH motif; other site 1205676006030 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205676006031 active site 1205676006032 KMSKS motif; other site 1205676006033 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1205676006034 putative tRNA binding surface [nucleotide binding]; other site 1205676006035 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1205676006036 active site 1205676006037 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205676006038 conserved hypothetical protein; Region: TIGR03843 1205676006039 conserved hypothetical protein; Region: TIGR03847 1205676006040 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205676006041 catalytic core [active] 1205676006042 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1205676006043 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1205676006044 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1205676006045 quinone interaction residues [chemical binding]; other site 1205676006046 active site 1205676006047 catalytic residues [active] 1205676006048 FMN binding site [chemical binding]; other site 1205676006049 substrate binding site [chemical binding]; other site 1205676006050 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1205676006051 substrate binding site [chemical binding]; other site 1205676006052 hypothetical protein; Provisional; Region: PRK07906 1205676006053 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1205676006054 putative metal binding site [ion binding]; other site 1205676006055 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1205676006056 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 1205676006057 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205676006058 active site 1205676006059 DivIVA domain; Region: DivI1A_domain; TIGR03544 1205676006060 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1205676006061 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1205676006062 Predicted integral membrane protein [Function unknown]; Region: COG0762 1205676006063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1205676006064 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1205676006065 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205676006066 catalytic residue [active] 1205676006067 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1205676006068 uncharacterized protein, YfiH family; Region: TIGR00726 1205676006069 cell division protein FtsZ; Validated; Region: PRK09330 1205676006070 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1205676006071 nucleotide binding site [chemical binding]; other site 1205676006072 SulA interaction site; other site 1205676006073 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1205676006074 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1205676006075 Cell division protein FtsQ; Region: FtsQ; pfam03799 1205676006076 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1205676006077 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1205676006078 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205676006079 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205676006080 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1205676006081 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 1205676006082 active site 1205676006083 homodimer interface [polypeptide binding]; other site 1205676006084 cell division protein FtsW; Region: ftsW; TIGR02614 1205676006085 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1205676006086 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205676006087 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205676006088 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1205676006089 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1205676006090 Mg++ binding site [ion binding]; other site 1205676006091 putative catalytic motif [active] 1205676006092 putative substrate binding site [chemical binding]; other site 1205676006093 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205676006094 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205676006095 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1205676006096 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1205676006097 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1205676006098 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205676006099 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676006100 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676006101 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1205676006102 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205676006103 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205676006104 PE family; Region: PE; pfam00934 1205676006105 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1205676006106 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1205676006107 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1205676006108 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1205676006109 MraW methylase family; Region: Methyltransf_5; pfam01795 1205676006110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1205676006111 MraZ protein; Region: MraZ; pfam02381 1205676006112 MraZ protein; Region: MraZ; pfam02381 1205676006113 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1205676006114 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 1205676006115 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205676006116 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205676006117 substrate binding pocket [chemical binding]; other site 1205676006118 chain length determination region; other site 1205676006119 substrate-Mg2+ binding site; other site 1205676006120 catalytic residues [active] 1205676006121 aspartate-rich region 1; other site 1205676006122 active site lid residues [active] 1205676006123 aspartate-rich region 2; other site 1205676006124 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1205676006125 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205676006126 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205676006127 active site 1205676006128 ATP binding site [chemical binding]; other site 1205676006129 substrate binding site [chemical binding]; other site 1205676006130 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1205676006131 substrate binding site [chemical binding]; other site 1205676006132 activation loop (A-loop); other site 1205676006133 activation loop (A-loop); other site 1205676006134 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205676006135 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200 1205676006136 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1205676006137 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205676006138 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205676006139 putative acyl-acceptor binding pocket; other site 1205676006140 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1205676006141 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1205676006142 DTAP/Switch II; other site 1205676006143 Switch I; other site 1205676006144 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1205676006145 putative hydrophobic ligand binding site [chemical binding]; other site 1205676006146 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1205676006147 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1205676006148 acyl-activating enzyme (AAE) consensus motif; other site 1205676006149 putative AMP binding site [chemical binding]; other site 1205676006150 putative active site [active] 1205676006151 putative CoA binding site [chemical binding]; other site 1205676006152 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205676006153 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205676006154 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1205676006155 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1205676006156 NlpC/P60 family; Region: NLPC_P60; pfam00877 1205676006157 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205676006158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205676006159 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205676006160 hypothetical protein; Validated; Region: PRK07883 1205676006161 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1205676006162 active site 1205676006163 catalytic site [active] 1205676006164 substrate binding site [chemical binding]; other site 1205676006165 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1205676006166 GIY-YIG motif/motif A; other site 1205676006167 active site 1205676006168 catalytic site [active] 1205676006169 putative DNA binding site [nucleotide binding]; other site 1205676006170 metal binding site [ion binding]; metal-binding site 1205676006171 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1205676006172 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1205676006173 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1205676006174 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1205676006175 Subunit I/III interface [polypeptide binding]; other site 1205676006176 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1205676006177 Cytochrome c; Region: Cytochrom_C; pfam00034 1205676006178 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1205676006179 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1205676006180 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1205676006181 iron-sulfur cluster [ion binding]; other site 1205676006182 [2Fe-2S] cluster binding site [ion binding]; other site 1205676006183 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1205676006184 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1205676006185 heme bH binding site [chemical binding]; other site 1205676006186 intrachain domain interface; other site 1205676006187 heme bL binding site [chemical binding]; other site 1205676006188 interchain domain interface [polypeptide binding]; other site 1205676006189 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1205676006190 Qo binding site; other site 1205676006191 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1205676006192 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1205676006193 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1205676006194 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1205676006195 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1205676006196 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1205676006197 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1205676006198 dimer interface [polypeptide binding]; other site 1205676006199 active site 1205676006200 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1205676006201 Ligand Binding Site [chemical binding]; other site 1205676006202 Molecular Tunnel; other site 1205676006203 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1205676006204 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1205676006205 substrate binding site [chemical binding]; other site 1205676006206 ATP binding site [chemical binding]; other site 1205676006207 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1205676006208 Glycerate kinase family; Region: Gly_kinase; pfam02595 1205676006209 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1205676006210 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1205676006211 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1205676006212 putative dimer interface [polypeptide binding]; other site 1205676006213 active site pocket [active] 1205676006214 putative cataytic base [active] 1205676006215 Cobalamin-5-phosphate synthase; Region: CobS; pfam02654 1205676006216 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1205676006217 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1205676006218 homodimer interface [polypeptide binding]; other site 1205676006219 substrate-cofactor binding pocket; other site 1205676006220 catalytic residue [active] 1205676006221 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1205676006222 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1205676006223 cyclase homology domain; Region: CHD; cd07302 1205676006224 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205676006225 nucleotidyl binding site; other site 1205676006226 metal binding site [ion binding]; metal-binding site 1205676006227 dimer interface [polypeptide binding]; other site 1205676006228 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1205676006229 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1205676006230 interface (dimer of trimers) [polypeptide binding]; other site 1205676006231 Substrate-binding/catalytic site; other site 1205676006232 Zn-binding sites [ion binding]; other site 1205676006233 short chain dehydrogenase; Validated; Region: PRK05855 1205676006234 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205676006235 classical (c) SDRs; Region: SDR_c; cd05233 1205676006236 NAD(P) binding site [chemical binding]; other site 1205676006237 active site 1205676006238 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1205676006239 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1205676006240 E3 interaction surface; other site 1205676006241 lipoyl attachment site [posttranslational modification]; other site 1205676006242 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1205676006243 E3 interaction surface; other site 1205676006244 lipoyl attachment site [posttranslational modification]; other site 1205676006245 e3 binding domain; Region: E3_binding; pfam02817 1205676006246 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205676006247 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1205676006248 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1205676006249 putative NAD(P) binding site [chemical binding]; other site 1205676006250 putative active site [active] 1205676006251 lipoate-protein ligase B; Provisional; Region: PRK14345 1205676006252 lipoyl synthase; Provisional; Region: PRK05481 1205676006253 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205676006254 FeS/SAM binding site; other site 1205676006255 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1205676006256 RDD family; Region: RDD; pfam06271 1205676006257 glutamine synthetase, type I; Region: GlnA; TIGR00653 1205676006258 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1205676006259 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1205676006260 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1205676006261 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1205676006262 metal binding triad; other site 1205676006263 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1205676006264 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1205676006265 metal binding triad; other site 1205676006266 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1205676006267 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1205676006268 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1205676006269 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1205676006270 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1205676006271 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205676006272 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1205676006273 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205676006274 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205676006275 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1205676006276 oligomerization interface [polypeptide binding]; other site 1205676006277 active site 1205676006278 metal binding site [ion binding]; metal-binding site 1205676006279 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1205676006280 putative active site; other site 1205676006281 putative metal binding residues [ion binding]; other site 1205676006282 signature motif; other site 1205676006283 putative triphosphate binding site [ion binding]; other site 1205676006284 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1205676006285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 1205676006286 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1205676006287 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1205676006288 RNA/DNA hybrid binding site [nucleotide binding]; other site 1205676006289 active site 1205676006290 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205676006291 catalytic core [active] 1205676006292 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1205676006293 Putative zinc ribbon domain; Region: DUF164; pfam02591 1205676006294 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1205676006295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1205676006296 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1205676006297 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1205676006298 hypothetical protein; Provisional; Region: PRK07908 1205676006299 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205676006300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676006301 homodimer interface [polypeptide binding]; other site 1205676006302 catalytic residue [active] 1205676006303 PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744 1205676006304 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1205676006305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205676006306 active site 1205676006307 motif I; other site 1205676006308 motif II; other site 1205676006309 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1205676006310 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1205676006311 active site 1205676006312 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1205676006313 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1205676006314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1205676006315 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1205676006316 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1205676006317 dimer interface [polypeptide binding]; other site 1205676006318 catalytic triad [active] 1205676006319 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1205676006320 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1205676006321 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1205676006322 dimer interface [polypeptide binding]; other site 1205676006323 TPP-binding site [chemical binding]; other site 1205676006324 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205676006325 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1205676006326 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1205676006327 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205676006328 acyl carrier protein; Provisional; Region: acpP; PRK00982 1205676006329 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1205676006330 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1205676006331 dimer interface [polypeptide binding]; other site 1205676006332 active site 1205676006333 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1205676006334 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1205676006335 dimer interface [polypeptide binding]; other site 1205676006336 active site 1205676006337 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205676006338 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1205676006339 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205676006340 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1205676006341 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1205676006342 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676006343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676006344 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205676006345 FAD binding domain; Region: FAD_binding_4; pfam01565 1205676006346 diacylglycerol kinase; Reviewed; Region: PRK11914 1205676006347 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1205676006348 Integrase core domain; Region: rve; pfam00665 1205676006349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1205676006350 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1205676006351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676006352 Walker A motif; other site 1205676006353 ATP binding site [chemical binding]; other site 1205676006354 Walker B motif; other site 1205676006355 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1205676006356 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205676006357 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205676006358 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205676006359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676006360 S-adenosylmethionine binding site [chemical binding]; other site 1205676006361 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1205676006362 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1205676006363 NAD binding site [chemical binding]; other site 1205676006364 catalytic Zn binding site [ion binding]; other site 1205676006365 substrate binding site [chemical binding]; other site 1205676006366 structural Zn binding site [ion binding]; other site 1205676006367 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205676006368 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 1205676006369 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1205676006370 putative active site [active] 1205676006371 catalytic triad [active] 1205676006372 putative dimer interface [polypeptide binding]; other site 1205676006373 short chain dehydrogenase; Provisional; Region: PRK05854 1205676006374 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1205676006375 putative NAD(P) binding site [chemical binding]; other site 1205676006376 active site 1205676006377 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205676006378 nucleotide binding site [chemical binding]; other site 1205676006379 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205676006380 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676006381 Cytochrome P450; Region: p450; cl12078 1205676006382 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1205676006383 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676006384 Cytochrome P450; Region: p450; cl12078 1205676006385 Septum formation; Region: Septum_form; pfam13845 1205676006386 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 1205676006387 Predicted membrane protein [Function unknown]; Region: COG2149 1205676006388 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1205676006389 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676006390 Cytochrome P450; Region: p450; cl12078 1205676006391 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 1205676006392 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1205676006393 putative active site [active] 1205676006394 catalytic site [active] 1205676006395 putative metal binding site [ion binding]; other site 1205676006396 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1205676006397 FAD binding domain; Region: FAD_binding_4; pfam01565 1205676006398 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1205676006399 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1205676006400 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1205676006401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205676006402 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1205676006403 dimerization interface [polypeptide binding]; other site 1205676006404 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205676006405 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205676006406 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205676006407 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205676006408 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205676006409 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1205676006410 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1205676006411 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1205676006412 CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134 1205676006413 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1205676006414 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1205676006415 active site residue [active] 1205676006416 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1205676006417 active site residue [active] 1205676006418 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1205676006419 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205676006420 Transposase; Region: HTH_Tnp_1; cl17663 1205676006421 Transposase; Region: HTH_Tnp_1; cl17663 1205676006422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205676006423 putative transposase OrfB; Reviewed; Region: PHA02517 1205676006424 HTH-like domain; Region: HTH_21; pfam13276 1205676006425 Integrase core domain; Region: rve; pfam00665 1205676006426 Integrase core domain; Region: rve_3; pfam13683 1205676006427 HTH-like domain; Region: HTH_21; pfam13276 1205676006428 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1205676006429 Integrase core domain; Region: rve; pfam00665 1205676006430 Integrase core domain; Region: rve_3; pfam13683 1205676006431 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1205676006432 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205676006433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676006434 homodimer interface [polypeptide binding]; other site 1205676006435 catalytic residue [active] 1205676006436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196 1205676006437 haloalkane dehalogenase; Provisional; Region: PRK00870 1205676006438 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205676006439 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205676006440 active site 1205676006441 catalytic tetrad [active] 1205676006442 heat shock protein 90; Provisional; Region: PRK05218 1205676006443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205676006444 ATP binding site [chemical binding]; other site 1205676006445 Mg2+ binding site [ion binding]; other site 1205676006446 G-X-G motif; other site 1205676006447 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205676006448 Cutinase; Region: Cutinase; pfam01083 1205676006449 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1205676006450 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1205676006451 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1205676006452 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1205676006453 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1205676006454 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205676006455 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1205676006456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1205676006457 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1205676006458 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205676006459 DNA binding site [nucleotide binding] 1205676006460 active site 1205676006461 Int/Topo IB signature motif; other site 1205676006462 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1205676006463 DNA binding residues [nucleotide binding] 1205676006464 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 1205676006465 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1205676006466 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1205676006467 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1205676006468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676006469 putative PBP binding loops; other site 1205676006470 ABC-ATPase subunit interface; other site 1205676006471 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205676006472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676006473 dimer interface [polypeptide binding]; other site 1205676006474 conserved gate region; other site 1205676006475 putative PBP binding loops; other site 1205676006476 ABC-ATPase subunit interface; other site 1205676006477 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1205676006478 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1205676006479 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205676006480 Ligand Binding Site [chemical binding]; other site 1205676006481 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205676006482 Ligand Binding Site [chemical binding]; other site 1205676006483 amino acid transporter; Region: 2A0306; TIGR00909 1205676006484 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1205676006485 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1205676006486 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205676006487 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205676006488 catalytic residue [active] 1205676006489 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1205676006490 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205676006491 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205676006492 Amidinotransferase; Region: Amidinotransf; pfam02274 1205676006493 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1205676006494 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1205676006495 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1205676006496 putative DNA binding site [nucleotide binding]; other site 1205676006497 putative Zn2+ binding site [ion binding]; other site 1205676006498 AsnC family; Region: AsnC_trans_reg; pfam01037 1205676006499 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1205676006500 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1205676006501 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1205676006502 Walker A/P-loop; other site 1205676006503 ATP binding site [chemical binding]; other site 1205676006504 Q-loop/lid; other site 1205676006505 ABC transporter signature motif; other site 1205676006506 Walker B; other site 1205676006507 D-loop; other site 1205676006508 H-loop/switch region; other site 1205676006509 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1205676006510 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1205676006511 Walker A/P-loop; other site 1205676006512 ATP binding site [chemical binding]; other site 1205676006513 Q-loop/lid; other site 1205676006514 ABC transporter signature motif; other site 1205676006515 Walker B; other site 1205676006516 D-loop; other site 1205676006517 H-loop/switch region; other site 1205676006518 MarR family; Region: MarR; pfam01047 1205676006519 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205676006520 PE family; Region: PE; pfam00934 1205676006521 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1205676006522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676006523 putative substrate translocation pore; other site 1205676006524 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1205676006525 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205676006526 malate dehydrogenase; Provisional; Region: PRK13529 1205676006527 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1205676006528 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1205676006529 NAD(P) binding site [chemical binding]; other site 1205676006530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676006531 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205676006532 putative substrate translocation pore; other site 1205676006533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676006534 putative substrate translocation pore; other site 1205676006535 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1205676006536 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1205676006537 dimer interface [polypeptide binding]; other site 1205676006538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676006539 catalytic residue [active] 1205676006540 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1205676006541 serine O-acetyltransferase; Region: cysE; TIGR01172 1205676006542 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1205676006543 trimer interface [polypeptide binding]; other site 1205676006544 active site 1205676006545 substrate binding site [chemical binding]; other site 1205676006546 CoA binding site [chemical binding]; other site 1205676006547 hypothetical protein; Provisional; Region: PRK14851 1205676006548 hypothetical protein; Validated; Region: PRK08223 1205676006549 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1205676006550 ATP binding site [chemical binding]; other site 1205676006551 substrate interface [chemical binding]; other site 1205676006552 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205676006553 PE family; Region: PE; pfam00934 1205676006554 DNA primase; Validated; Region: dnaG; PRK05667 1205676006555 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1205676006556 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1205676006557 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1205676006558 active site 1205676006559 metal binding site [ion binding]; metal-binding site 1205676006560 interdomain interaction site; other site 1205676006561 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1205676006562 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1205676006563 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1205676006564 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205676006565 Zn2+ binding site [ion binding]; other site 1205676006566 Mg2+ binding site [ion binding]; other site 1205676006567 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1205676006568 Repair protein; Region: Repair_PSII; pfam04536 1205676006569 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205676006570 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1205676006571 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1205676006572 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1205676006573 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1205676006574 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1205676006575 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 1205676006576 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1205676006577 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676006578 PPE family; Region: PPE; pfam00823 1205676006579 PPE family; Region: PPE; pfam00823 1205676006580 PPE family; Region: PPE; pfam00823 1205676006581 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1205676006582 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205676006583 motif 1; other site 1205676006584 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1205676006585 active site 1205676006586 motif 2; other site 1205676006587 motif 3; other site 1205676006588 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1205676006589 anticodon binding site; other site 1205676006590 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205676006591 dimerization interface [polypeptide binding]; other site 1205676006592 putative DNA binding site [nucleotide binding]; other site 1205676006593 putative Zn2+ binding site [ion binding]; other site 1205676006594 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1205676006595 metal binding site 2 [ion binding]; metal-binding site 1205676006596 putative DNA binding helix; other site 1205676006597 metal binding site 1 [ion binding]; metal-binding site 1205676006598 dimer interface [polypeptide binding]; other site 1205676006599 structural Zn2+ binding site [ion binding]; other site 1205676006600 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1205676006601 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1205676006602 catalytic residue [active] 1205676006603 putative FPP diphosphate binding site; other site 1205676006604 putative FPP binding hydrophobic cleft; other site 1205676006605 dimer interface [polypeptide binding]; other site 1205676006606 putative IPP diphosphate binding site; other site 1205676006607 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1205676006608 Recombination protein O N terminal; Region: RecO_N; pfam11967 1205676006609 Recombination protein O C terminal; Region: RecO_C; pfam02565 1205676006610 amidase; Provisional; Region: PRK06061 1205676006611 Amidase; Region: Amidase; pfam01425 1205676006612 GTPase Era; Reviewed; Region: era; PRK00089 1205676006613 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1205676006614 G1 box; other site 1205676006615 GTP/Mg2+ binding site [chemical binding]; other site 1205676006616 Switch I region; other site 1205676006617 G2 box; other site 1205676006618 Switch II region; other site 1205676006619 G3 box; other site 1205676006620 G4 box; other site 1205676006621 G5 box; other site 1205676006622 KH domain; Region: KH_2; pfam07650 1205676006623 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1205676006624 Domain of unknown function DUF21; Region: DUF21; pfam01595 1205676006625 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1205676006626 Transporter associated domain; Region: CorC_HlyC; smart01091 1205676006627 metal-binding heat shock protein; Provisional; Region: PRK00016 1205676006628 K homology RNA-binding domain; Region: KH; smart00322 1205676006629 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1205676006630 PhoH-like protein; Region: PhoH; pfam02562 1205676006631 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1205676006632 PE family; Region: PE; pfam00934 1205676006633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1205676006634 RNA methyltransferase, RsmE family; Region: TIGR00046 1205676006635 chaperone protein DnaJ; Provisional; Region: PRK14278 1205676006636 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1205676006637 HSP70 interaction site [polypeptide binding]; other site 1205676006638 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1205676006639 Zn binding sites [ion binding]; other site 1205676006640 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1205676006641 dimer interface [polypeptide binding]; other site 1205676006642 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1205676006643 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205676006644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1205676006645 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205676006646 Condensation domain; Region: Condensation; pfam00668 1205676006647 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205676006648 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205676006649 acyl-activating enzyme (AAE) consensus motif; other site 1205676006650 AMP binding site [chemical binding]; other site 1205676006651 Condensation domain; Region: Condensation; pfam00668 1205676006652 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1205676006653 Condensation domain; Region: Condensation; pfam00668 1205676006654 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205676006655 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1205676006656 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1205676006657 acyl-activating enzyme (AAE) consensus motif; other site 1205676006658 AMP binding site [chemical binding]; other site 1205676006659 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205676006660 Condensation domain; Region: Condensation; pfam00668 1205676006661 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205676006662 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1205676006663 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676006664 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205676006665 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205676006666 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205676006667 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1205676006668 NADP binding site [chemical binding]; other site 1205676006669 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205676006670 active site 1205676006671 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676006672 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676006673 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205676006674 active site 1205676006675 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1205676006676 Condensation domain; Region: Condensation; pfam00668 1205676006677 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1205676006678 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1205676006679 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1205676006680 acyl-activating enzyme (AAE) consensus motif; other site 1205676006681 AMP binding site [chemical binding]; other site 1205676006682 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205676006683 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1205676006684 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1205676006685 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1205676006686 acyl-activating enzyme (AAE) consensus motif; other site 1205676006687 active site 1205676006688 AMP binding site [chemical binding]; other site 1205676006689 substrate binding site [chemical binding]; other site 1205676006690 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1205676006691 salicylate synthase MbtI; Reviewed; Region: PRK07912 1205676006692 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1205676006693 Predicted permease [General function prediction only]; Region: COG3329 1205676006694 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1205676006695 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1205676006696 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 12775759, 15525680 1205676006697 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 12775759, 15525680 1205676006698 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1205676006699 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1205676006700 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1205676006701 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1205676006702 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1205676006703 Active Sites [active] 1205676006704 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1205676006705 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1205676006706 putative active site [active] 1205676006707 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1205676006708 putative active site [active] 1205676006709 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1205676006710 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1205676006711 Predicted membrane protein [Function unknown]; Region: COG1297 1205676006712 putative oligopeptide transporter, OPT family; Region: TIGR00733 1205676006713 PE family; Region: PE; pfam00934 1205676006714 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1205676006715 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1205676006716 Walker A/P-loop; other site 1205676006717 ATP binding site [chemical binding]; other site 1205676006718 Q-loop/lid; other site 1205676006719 ABC transporter signature motif; other site 1205676006720 Walker B; other site 1205676006721 D-loop; other site 1205676006722 H-loop/switch region; other site 1205676006723 sulfate transport protein; Provisional; Region: cysT; CHL00187 1205676006724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676006725 dimer interface [polypeptide binding]; other site 1205676006726 conserved gate region; other site 1205676006727 putative PBP binding loops; other site 1205676006728 ABC-ATPase subunit interface; other site 1205676006729 sulfate transport protein; Provisional; Region: cysT; CHL00187 1205676006730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676006731 dimer interface [polypeptide binding]; other site 1205676006732 conserved gate region; other site 1205676006733 putative PBP binding loops; other site 1205676006734 ABC-ATPase subunit interface; other site 1205676006735 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1205676006736 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1205676006737 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1205676006738 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1205676006739 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1205676006740 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205676006741 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205676006742 GTP-binding protein LepA; Provisional; Region: PRK05433 1205676006743 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1205676006744 G1 box; other site 1205676006745 putative GEF interaction site [polypeptide binding]; other site 1205676006746 GTP/Mg2+ binding site [chemical binding]; other site 1205676006747 Switch I region; other site 1205676006748 G2 box; other site 1205676006749 G3 box; other site 1205676006750 Switch II region; other site 1205676006751 G4 box; other site 1205676006752 G5 box; other site 1205676006753 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1205676006754 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1205676006755 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1205676006756 PemK-like protein; Region: PemK; pfam02452 1205676006757 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1205676006758 FOG: CBS domain [General function prediction only]; Region: COG0517 1205676006759 ribonuclease Z; Reviewed; Region: PRK00055 1205676006760 PE family; Region: PE; pfam00934 1205676006761 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205676006762 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1205676006763 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1205676006764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1205676006765 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1205676006766 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1205676006767 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1205676006768 hypothetical protein; Reviewed; Region: PRK07914 1205676006769 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1205676006770 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1205676006771 Competence protein; Region: Competence; pfam03772 1205676006772 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1205676006773 Helix-hairpin-helix motif; Region: HHH; pfam00633 1205676006774 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1205676006775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205676006776 Coenzyme A binding pocket [chemical binding]; other site 1205676006777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1205676006778 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1205676006779 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1205676006780 active site 1205676006781 catalytic triad [active] 1205676006782 oxyanion hole [active] 1205676006783 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205676006784 catalytic core [active] 1205676006785 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1205676006786 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1205676006787 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1205676006788 active site 1205676006789 (T/H)XGH motif; other site 1205676006790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676006791 S-adenosylmethionine binding site [chemical binding]; other site 1205676006792 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205676006793 putative transposase OrfB; Reviewed; Region: PHA02517 1205676006794 HTH-like domain; Region: HTH_21; pfam13276 1205676006795 Integrase core domain; Region: rve; pfam00665 1205676006796 Integrase core domain; Region: rve_3; pfam13683 1205676006797 Transposase; Region: HTH_Tnp_1; cl17663 1205676006798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205676006799 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205676006800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205676006801 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205676006802 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205676006803 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1205676006804 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1205676006805 metal ion-dependent adhesion site (MIDAS); other site 1205676006806 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1205676006807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676006808 Walker A motif; other site 1205676006809 ATP binding site [chemical binding]; other site 1205676006810 Walker B motif; other site 1205676006811 arginine finger; other site 1205676006812 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1205676006813 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1205676006814 putative catalytic cysteine [active] 1205676006815 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1205676006816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1205676006817 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1205676006818 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1205676006819 dimer interface [polypeptide binding]; other site 1205676006820 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1205676006821 catalytic triad [active] 1205676006822 peroxidatic and resolving cysteines [active] 1205676006823 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1205676006824 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1205676006825 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676006826 PPE family; Region: PPE; pfam00823 1205676006827 PE family; Region: PE; pfam00934 1205676006828 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1205676006829 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1205676006830 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205676006831 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205676006832 ligand binding site [chemical binding]; other site 1205676006833 flexible hinge region; other site 1205676006834 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205676006835 dimerization interface [polypeptide binding]; other site 1205676006836 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1205676006837 cyclase homology domain; Region: CHD; cd07302 1205676006838 nucleotidyl binding site; other site 1205676006839 metal binding site [ion binding]; metal-binding site 1205676006840 dimer interface [polypeptide binding]; other site 1205676006841 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1205676006842 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1205676006843 substrate binding site [chemical binding]; other site 1205676006844 dimer interface [polypeptide binding]; other site 1205676006845 ATP binding site [chemical binding]; other site 1205676006846 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1205676006847 NAD synthetase; Reviewed; Region: nadE; PRK02628 1205676006848 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1205676006849 multimer interface [polypeptide binding]; other site 1205676006850 active site 1205676006851 catalytic triad [active] 1205676006852 protein interface 1 [polypeptide binding]; other site 1205676006853 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1205676006854 homodimer interface [polypeptide binding]; other site 1205676006855 NAD binding pocket [chemical binding]; other site 1205676006856 ATP binding pocket [chemical binding]; other site 1205676006857 Mg binding site [ion binding]; other site 1205676006858 active-site loop [active] 1205676006859 gamma-glutamyl kinase; Provisional; Region: PRK05429 1205676006860 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1205676006861 nucleotide binding site [chemical binding]; other site 1205676006862 homotetrameric interface [polypeptide binding]; other site 1205676006863 putative phosphate binding site [ion binding]; other site 1205676006864 putative allosteric binding site; other site 1205676006865 PUA domain; Region: PUA; pfam01472 1205676006866 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1205676006867 GTP1/OBG; Region: GTP1_OBG; pfam01018 1205676006868 Obg GTPase; Region: Obg; cd01898 1205676006869 G1 box; other site 1205676006870 GTP/Mg2+ binding site [chemical binding]; other site 1205676006871 Switch I region; other site 1205676006872 G2 box; other site 1205676006873 G3 box; other site 1205676006874 Switch II region; other site 1205676006875 G4 box; other site 1205676006876 G5 box; other site 1205676006877 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1205676006878 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1205676006879 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1205676006880 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1205676006881 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1205676006882 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1205676006883 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1205676006884 homodimer interface [polypeptide binding]; other site 1205676006885 oligonucleotide binding site [chemical binding]; other site 1205676006886 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1205676006887 active site 1205676006888 multimer interface [polypeptide binding]; other site 1205676006889 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1205676006890 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1205676006891 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1205676006892 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1205676006893 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205676006894 active site 1205676006895 HIGH motif; other site 1205676006896 nucleotide binding site [chemical binding]; other site 1205676006897 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1205676006898 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1205676006899 active site 1205676006900 KMSKS motif; other site 1205676006901 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1205676006902 tRNA binding surface [nucleotide binding]; other site 1205676006903 anticodon binding site; other site 1205676006904 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1205676006905 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1205676006906 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1205676006907 NAD(P) binding pocket [chemical binding]; other site 1205676006908 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1205676006909 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1205676006910 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1205676006911 GTP binding site; other site 1205676006912 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1205676006913 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1205676006914 TPP-binding site [chemical binding]; other site 1205676006915 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1205676006916 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1205676006917 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1205676006918 dimer interface [polypeptide binding]; other site 1205676006919 PYR/PP interface [polypeptide binding]; other site 1205676006920 TPP binding site [chemical binding]; other site 1205676006921 substrate binding site [chemical binding]; other site 1205676006922 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1205676006923 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1205676006924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676006925 Walker A motif; other site 1205676006926 ATP binding site [chemical binding]; other site 1205676006927 Walker B motif; other site 1205676006928 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1205676006929 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1205676006930 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1205676006931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676006932 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205676006933 putative substrate translocation pore; other site 1205676006934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676006935 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1205676006936 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1205676006937 oligomer interface [polypeptide binding]; other site 1205676006938 active site residues [active] 1205676006939 Clp protease; Region: CLP_protease; pfam00574 1205676006940 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1205676006941 oligomer interface [polypeptide binding]; other site 1205676006942 active site residues [active] 1205676006943 trigger factor; Provisional; Region: tig; PRK01490 1205676006944 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1205676006945 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1205676006946 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205676006947 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205676006948 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1205676006949 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1205676006950 putative DNA binding site [nucleotide binding]; other site 1205676006951 catalytic residue [active] 1205676006952 putative H2TH interface [polypeptide binding]; other site 1205676006953 putative catalytic residues [active] 1205676006954 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1205676006955 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1205676006956 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1205676006957 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1205676006958 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1205676006959 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1205676006960 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1205676006961 Zn binding site [ion binding]; other site 1205676006962 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1205676006963 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205676006964 active site 1205676006965 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1205676006966 apolar tunnel; other site 1205676006967 heme binding site [chemical binding]; other site 1205676006968 dimerization interface [polypeptide binding]; other site 1205676006969 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1205676006970 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1205676006971 active site 1205676006972 catalytic site [active] 1205676006973 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1205676006974 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1205676006975 active site 1205676006976 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 1205676006977 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1205676006978 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205676006979 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205676006980 ABC transporter; Region: ABC_tran_2; pfam12848 1205676006981 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1205676006982 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1205676006983 dimer interface [polypeptide binding]; other site 1205676006984 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1205676006985 ssDNA binding site [nucleotide binding]; other site 1205676006986 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1205676006987 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1205676006988 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1205676006989 putative acyl-acceptor binding pocket; other site 1205676006990 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1205676006991 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1205676006992 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205676006993 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205676006994 putative acyl-acceptor binding pocket; other site 1205676006995 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205676006996 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205676006997 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1205676006998 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205676006999 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205676007000 enoyl-CoA hydratase; Provisional; Region: PRK05870 1205676007001 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676007002 substrate binding site [chemical binding]; other site 1205676007003 oxyanion hole (OAH) forming residues; other site 1205676007004 trimer interface [polypeptide binding]; other site 1205676007005 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1205676007006 PE family; Region: PE; pfam00934 1205676007007 PE family; Region: PE; pfam00934 1205676007008 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205676007009 cyclase homology domain; Region: CHD; cd07302 1205676007010 nucleotidyl binding site; other site 1205676007011 metal binding site [ion binding]; metal-binding site 1205676007012 dimer interface [polypeptide binding]; other site 1205676007013 Predicted ATPase [General function prediction only]; Region: COG3903 1205676007014 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205676007015 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205676007016 DNA binding residues [nucleotide binding] 1205676007017 dimerization interface [polypeptide binding]; other site 1205676007018 PE family; Region: PE; pfam00934 1205676007019 TIGR00725 family protein; Region: TIGR00725 1205676007020 thymidylate synthase; Provisional; Region: thyA; PRK00956 1205676007021 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205676007022 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1205676007023 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1205676007024 E3 interaction surface; other site 1205676007025 lipoyl attachment site [posttranslational modification]; other site 1205676007026 e3 binding domain; Region: E3_binding; pfam02817 1205676007027 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1205676007028 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1205676007029 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1205676007030 alpha subunit interface [polypeptide binding]; other site 1205676007031 TPP binding site [chemical binding]; other site 1205676007032 heterodimer interface [polypeptide binding]; other site 1205676007033 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1205676007034 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1205676007035 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1205676007036 tetramer interface [polypeptide binding]; other site 1205676007037 TPP-binding site [chemical binding]; other site 1205676007038 heterodimer interface [polypeptide binding]; other site 1205676007039 phosphorylation loop region [posttranslational modification] 1205676007040 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1205676007041 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1205676007042 putative active site [active] 1205676007043 putative catalytic site [active] 1205676007044 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676007045 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676007046 active site 1205676007047 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1205676007048 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205676007049 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1205676007050 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1205676007051 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205676007052 carboxyltransferase (CT) interaction site; other site 1205676007053 biotinylation site [posttranslational modification]; other site 1205676007054 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205676007055 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1205676007056 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205676007057 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1205676007058 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1205676007059 AMP-binding domain protein; Validated; Region: PRK08315 1205676007060 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676007061 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1205676007062 acyl-activating enzyme (AAE) consensus motif; other site 1205676007063 acyl-activating enzyme (AAE) consensus motif; other site 1205676007064 putative AMP binding site [chemical binding]; other site 1205676007065 putative active site [active] 1205676007066 putative CoA binding site [chemical binding]; other site 1205676007067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676007068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676007069 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1205676007070 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1205676007071 classical (c) SDRs; Region: SDR_c; cd05233 1205676007072 NAD(P) binding site [chemical binding]; other site 1205676007073 active site 1205676007074 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1205676007075 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1205676007076 catalytic site [active] 1205676007077 putative active site [active] 1205676007078 putative substrate binding site [chemical binding]; other site 1205676007079 dimer interface [polypeptide binding]; other site 1205676007080 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046 1205676007081 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1205676007082 MULE transposase domain; Region: MULE; pfam10551 1205676007083 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046 1205676007084 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 1205676007085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205676007086 non-specific DNA binding site [nucleotide binding]; other site 1205676007087 salt bridge; other site 1205676007088 sequence-specific DNA binding site [nucleotide binding]; other site 1205676007089 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1205676007090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1205676007091 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1205676007092 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1205676007093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1205676007094 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1205676007095 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1205676007096 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1205676007097 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205676007098 catalytic triad [active] 1205676007099 hypothetical protein; Provisional; Region: PRK07907 1205676007100 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1205676007101 active site 1205676007102 metal binding site [ion binding]; metal-binding site 1205676007103 dimer interface [polypeptide binding]; other site 1205676007104 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1205676007105 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1205676007106 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1205676007107 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205676007108 phosphate binding site [ion binding]; other site 1205676007109 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1205676007110 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1205676007111 putative active site [active] 1205676007112 putative catalytic site [active] 1205676007113 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1205676007114 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205676007115 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1205676007116 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1205676007117 putative NAD(P) binding site [chemical binding]; other site 1205676007118 active site 1205676007119 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1205676007120 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1205676007121 active site 1205676007122 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1205676007123 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205676007124 putative active site [active] 1205676007125 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1205676007126 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1205676007127 Restriction endonuclease; Region: Mrr_cat; pfam04471 1205676007128 ERCC4 domain; Region: ERCC4; pfam02732 1205676007129 Lsr2; Region: Lsr2; pfam11774 1205676007130 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205676007131 putative active site [active] 1205676007132 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1205676007133 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205676007134 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205676007135 catalytic residue [active] 1205676007136 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1205676007137 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1205676007138 putative RNA binding site [nucleotide binding]; other site 1205676007139 elongation factor P; Validated; Region: PRK00529 1205676007140 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1205676007141 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1205676007142 RNA binding site [nucleotide binding]; other site 1205676007143 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1205676007144 RNA binding site [nucleotide binding]; other site 1205676007145 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1205676007146 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1205676007147 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1205676007148 active site 1205676007149 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1205676007150 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1205676007151 trimer interface [polypeptide binding]; other site 1205676007152 active site 1205676007153 dimer interface [polypeptide binding]; other site 1205676007154 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1205676007155 active site 1205676007156 dimer interface [polypeptide binding]; other site 1205676007157 metal binding site [ion binding]; metal-binding site 1205676007158 shikimate kinase; Reviewed; Region: aroK; PRK00131 1205676007159 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1205676007160 ADP binding site [chemical binding]; other site 1205676007161 magnesium binding site [ion binding]; other site 1205676007162 putative shikimate binding site; other site 1205676007163 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1205676007164 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1205676007165 Tetramer interface [polypeptide binding]; other site 1205676007166 active site 1205676007167 FMN-binding site [chemical binding]; other site 1205676007168 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1205676007169 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15024109, 17443846 1205676007170 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15024109 1205676007171 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205676007172 putative active site [active] 1205676007173 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205676007174 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1205676007175 oligomeric interface; other site 1205676007176 putative active site [active] 1205676007177 homodimer interface [polypeptide binding]; other site 1205676007178 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 1205676007179 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205676007180 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1205676007181 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 1205676007182 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1205676007183 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1205676007184 NAD(P) binding site [chemical binding]; other site 1205676007185 shikimate binding site; other site 1205676007186 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1205676007187 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1205676007188 dimerization interface [polypeptide binding]; other site 1205676007189 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1205676007190 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1205676007191 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1205676007192 motif 1; other site 1205676007193 active site 1205676007194 motif 2; other site 1205676007195 motif 3; other site 1205676007196 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1205676007197 DHHA1 domain; Region: DHHA1; pfam02272 1205676007198 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1205676007199 recombination factor protein RarA; Reviewed; Region: PRK13342 1205676007200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676007201 Walker A motif; other site 1205676007202 ATP binding site [chemical binding]; other site 1205676007203 Walker B motif; other site 1205676007204 arginine finger; other site 1205676007205 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1205676007206 Predicted integral membrane protein [Function unknown]; Region: COG5473 1205676007207 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1205676007208 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1205676007209 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1205676007210 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1205676007211 Walker A/P-loop; other site 1205676007212 ATP binding site [chemical binding]; other site 1205676007213 Q-loop/lid; other site 1205676007214 ABC transporter signature motif; other site 1205676007215 Walker B; other site 1205676007216 D-loop; other site 1205676007217 H-loop/switch region; other site 1205676007218 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205676007219 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205676007220 ligand binding site [chemical binding]; other site 1205676007221 flexible hinge region; other site 1205676007222 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205676007223 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205676007224 ligand binding site [chemical binding]; other site 1205676007225 flexible hinge region; other site 1205676007226 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1205676007227 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1205676007228 active site 1205676007229 nucleophile elbow; other site 1205676007230 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205676007231 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1205676007232 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1205676007233 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1205676007234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1205676007235 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1205676007236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1205676007237 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1205676007238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1205676007239 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1205676007240 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1205676007241 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1205676007242 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1205676007243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801 1205676007244 Predicted membrane protein [Function unknown]; Region: COG4129 1205676007245 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1205676007246 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1205676007247 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1205676007248 dimer interface [polypeptide binding]; other site 1205676007249 anticodon binding site; other site 1205676007250 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1205676007251 homodimer interface [polypeptide binding]; other site 1205676007252 motif 1; other site 1205676007253 active site 1205676007254 motif 2; other site 1205676007255 GAD domain; Region: GAD; pfam02938 1205676007256 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205676007257 active site 1205676007258 motif 3; other site 1205676007259 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1205676007260 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1205676007261 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1205676007262 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1205676007263 putative hydrophobic ligand binding site [chemical binding]; other site 1205676007264 protein interface [polypeptide binding]; other site 1205676007265 gate; other site 1205676007266 Predicted metalloprotease [General function prediction only]; Region: COG2321 1205676007267 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1205676007268 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1205676007269 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1205676007270 active site 1205676007271 metal binding site [ion binding]; metal-binding site 1205676007272 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1205676007273 haloalkane dehalogenase; Provisional; Region: PRK03592 1205676007274 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1205676007275 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1205676007276 dimer interface [polypeptide binding]; other site 1205676007277 motif 1; other site 1205676007278 active site 1205676007279 motif 2; other site 1205676007280 motif 3; other site 1205676007281 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1205676007282 anticodon binding site; other site 1205676007283 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1205676007284 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1205676007285 active site 1205676007286 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1205676007287 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205676007288 Zn2+ binding site [ion binding]; other site 1205676007289 Mg2+ binding site [ion binding]; other site 1205676007290 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1205676007291 synthetase active site [active] 1205676007292 NTP binding site [chemical binding]; other site 1205676007293 metal binding site [ion binding]; metal-binding site 1205676007294 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1205676007295 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1205676007296 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205676007297 active site 1205676007298 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1205676007299 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1205676007300 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1205676007301 Protein export membrane protein; Region: SecD_SecF; pfam02355 1205676007302 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1205676007303 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1205676007304 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1205676007305 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1205676007306 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205676007307 inhibitor-cofactor binding pocket; inhibition site 1205676007308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676007309 catalytic residue [active] 1205676007310 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1205676007311 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676007312 acyl-activating enzyme (AAE) consensus motif; other site 1205676007313 AMP binding site [chemical binding]; other site 1205676007314 active site 1205676007315 CoA binding site [chemical binding]; other site 1205676007316 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1205676007317 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1205676007318 putative NAD(P) binding site [chemical binding]; other site 1205676007319 active site 1205676007320 putative substrate binding site [chemical binding]; other site 1205676007321 PE family; Region: PE; pfam00934 1205676007322 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1205676007323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676007324 Walker A motif; other site 1205676007325 ATP binding site [chemical binding]; other site 1205676007326 Walker B motif; other site 1205676007327 arginine finger; other site 1205676007328 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1205676007329 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1205676007330 RuvA N terminal domain; Region: RuvA_N; pfam01330 1205676007331 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1205676007332 active site 1205676007333 putative DNA-binding cleft [nucleotide binding]; other site 1205676007334 dimer interface [polypeptide binding]; other site 1205676007335 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1205676007336 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1205676007337 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205676007338 putative active site [active] 1205676007339 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1205676007340 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1205676007341 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1205676007342 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1205676007343 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 1205676007344 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 1205676007345 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1205676007346 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205676007347 hypothetical protein; Validated; Region: PRK00110 1205676007348 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1205676007349 predicted active site [active] 1205676007350 catalytic triad [active] 1205676007351 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1205676007352 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1205676007353 active site 1205676007354 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1205676007355 catalytic triad [active] 1205676007356 dimer interface [polypeptide binding]; other site 1205676007357 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1205676007358 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1205676007359 active site 1205676007360 multimer interface [polypeptide binding]; other site 1205676007361 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 1205676007362 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1205676007363 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1205676007364 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676007365 PPE family; Region: PPE; pfam00823 1205676007366 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676007367 PE-PPE domain; Region: PE-PPE; pfam08237 1205676007368 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1205676007369 nudix motif; other site 1205676007370 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205676007371 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205676007372 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1205676007373 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1205676007374 putative acyl-acceptor binding pocket; other site 1205676007375 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1205676007376 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1205676007377 nucleotide binding site/active site [active] 1205676007378 HIT family signature motif; other site 1205676007379 catalytic residue [active] 1205676007380 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1205676007381 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1205676007382 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1205676007383 active site 1205676007384 dimer interface [polypeptide binding]; other site 1205676007385 motif 1; other site 1205676007386 motif 2; other site 1205676007387 motif 3; other site 1205676007388 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1205676007389 anticodon binding site; other site 1205676007390 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205676007391 phosphate binding site [ion binding]; other site 1205676007392 PE family; Region: PE; pfam00934 1205676007393 PE family; Region: PE; pfam00934 1205676007394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762 1205676007395 Predicted transcriptional regulator [Transcription]; Region: COG2345 1205676007396 Helix-turn-helix domain; Region: HTH_20; pfam12840 1205676007397 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1205676007398 Predicted transcriptional regulator [Transcription]; Region: COG2345 1205676007399 Helix-turn-helix domain; Region: HTH_20; pfam12840 1205676007400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676007401 S-adenosylmethionine binding site [chemical binding]; other site 1205676007402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205676007403 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205676007404 Ligand Binding Site [chemical binding]; other site 1205676007405 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205676007406 Ligand Binding Site [chemical binding]; other site 1205676007407 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205676007408 Ligand Binding Site [chemical binding]; other site 1205676007409 Universal stress protein family; Region: Usp; pfam00582 1205676007410 Ligand Binding Site [chemical binding]; other site 1205676007411 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1205676007412 active site 1205676007413 Peptidase family M50; Region: Peptidase_M50; pfam02163 1205676007414 putative substrate binding region [chemical binding]; other site 1205676007415 FOG: CBS domain [General function prediction only]; Region: COG0517 1205676007416 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1205676007417 FOG: CBS domain [General function prediction only]; Region: COG0517 1205676007418 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1205676007419 peptide chain release factor 1; Provisional; Region: PRK04011 1205676007420 SHS2 domain protein implicated in nucleic acid metabolism [General function prediction only]; Region: COG1371 1205676007421 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 1205676007422 hypothetical protein; Reviewed; Region: PRK09588 1205676007423 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1205676007424 Hemerythrin-like domain; Region: Hr-like; cd12108 1205676007425 Fe binding site [ion binding]; other site 1205676007426 PE family; Region: PE; pfam00934 1205676007427 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227 1205676007428 P-loop motif; other site 1205676007429 ATP binding site [chemical binding]; other site 1205676007430 Chloramphenicol (Cm) binding site [chemical binding]; other site 1205676007431 catalytic residue [active] 1205676007432 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1205676007433 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1205676007434 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205676007435 anti sigma factor interaction site; other site 1205676007436 regulatory phosphorylation site [posttranslational modification]; other site 1205676007437 hypothetical protein; Provisional; Region: PRK02237 1205676007438 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205676007439 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1205676007440 putative DNA binding site [nucleotide binding]; other site 1205676007441 putative Zn2+ binding site [ion binding]; other site 1205676007442 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1205676007443 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1205676007444 putative metal binding site [ion binding]; other site 1205676007445 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205676007446 dimerization interface [polypeptide binding]; other site 1205676007447 putative DNA binding site [nucleotide binding]; other site 1205676007448 putative Zn2+ binding site [ion binding]; other site 1205676007449 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1205676007450 arsenical-resistance protein; Region: acr3; TIGR00832 1205676007451 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1205676007452 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1205676007453 active site 1205676007454 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1205676007455 MULE transposase domain; Region: MULE; pfam10551 1205676007456 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1205676007457 Clp amino terminal domain; Region: Clp_N; pfam02861 1205676007458 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1205676007459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205676007460 Coenzyme A binding pocket [chemical binding]; other site 1205676007461 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1205676007462 hypothetical protein; Provisional; Region: PRK14059 1205676007463 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1205676007464 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676007465 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205676007466 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1205676007467 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1205676007468 SelR domain; Region: SelR; pfam01641 1205676007469 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205676007470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676007471 S-adenosylmethionine binding site [chemical binding]; other site 1205676007472 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1205676007473 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1205676007474 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205676007475 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205676007476 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1205676007477 substrate binding site [chemical binding]; other site 1205676007478 active site 1205676007479 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676007480 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205676007481 substrate binding site [chemical binding]; other site 1205676007482 oxyanion hole (OAH) forming residues; other site 1205676007483 trimer interface [polypeptide binding]; other site 1205676007484 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1205676007485 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1205676007486 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1205676007487 catalytic site [active] 1205676007488 putative active site [active] 1205676007489 putative substrate binding site [chemical binding]; other site 1205676007490 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1205676007491 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1205676007492 TPP-binding site; other site 1205676007493 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1205676007494 PYR/PP interface [polypeptide binding]; other site 1205676007495 dimer interface [polypeptide binding]; other site 1205676007496 TPP binding site [chemical binding]; other site 1205676007497 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1205676007498 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1205676007499 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1205676007500 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1205676007501 transmembrane helices; other site 1205676007502 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1205676007503 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1205676007504 transmembrane helices; other site 1205676007505 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1205676007506 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1205676007507 Walker A/P-loop; other site 1205676007508 ATP binding site [chemical binding]; other site 1205676007509 Q-loop/lid; other site 1205676007510 ABC transporter signature motif; other site 1205676007511 Walker B; other site 1205676007512 D-loop; other site 1205676007513 H-loop/switch region; other site 1205676007514 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1205676007515 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1205676007516 TrkA-N domain; Region: TrkA_N; pfam02254 1205676007517 TrkA-C domain; Region: TrkA_C; pfam02080 1205676007518 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1205676007519 TrkA-N domain; Region: TrkA_N; pfam02254 1205676007520 TrkA-C domain; Region: TrkA_C; pfam02080 1205676007521 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1205676007522 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1205676007523 generic binding surface II; other site 1205676007524 ssDNA binding site; other site 1205676007525 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1205676007526 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1205676007527 trimer interface [polypeptide binding]; other site 1205676007528 active site 1205676007529 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1205676007530 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1205676007531 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205676007532 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1205676007533 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1205676007534 active site 1205676007535 dimerization interface [polypeptide binding]; other site 1205676007536 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1205676007537 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205676007538 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1205676007539 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205676007540 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1205676007541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205676007542 DNA binding residues [nucleotide binding] 1205676007543 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1205676007544 homotrimer interaction site [polypeptide binding]; other site 1205676007545 putative active site [active] 1205676007546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 1205676007547 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1205676007548 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1205676007549 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1205676007550 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1205676007551 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1205676007552 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205676007553 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1205676007554 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205676007555 DNA binding residues [nucleotide binding] 1205676007556 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1205676007557 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1205676007558 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1205676007559 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1205676007560 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1205676007561 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1205676007562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205676007563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205676007564 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205676007565 PAC2 family; Region: PAC2; pfam09754 1205676007566 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676007567 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1205676007568 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1205676007569 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1205676007570 heme-binding site [chemical binding]; other site 1205676007571 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1205676007572 ATP cone domain; Region: ATP-cone; pfam03477 1205676007573 LysM domain; Region: LysM; pfam01476 1205676007574 LexA repressor; Validated; Region: PRK00215 1205676007575 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1205676007576 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1205676007577 Catalytic site [active] 1205676007578 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1205676007579 LGFP repeat; Region: LGFP; pfam08310 1205676007580 LGFP repeat; Region: LGFP; pfam08310 1205676007581 LGFP repeat; Region: LGFP; pfam08310 1205676007582 LGFP repeat; Region: LGFP; pfam08310 1205676007583 LGFP repeat; Region: LGFP; pfam08310 1205676007584 Integral membrane protein TerC family; Region: TerC; cl10468 1205676007585 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676007586 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676007587 active site 1205676007588 GTPases [General function prediction only]; Region: HflX; COG2262 1205676007589 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1205676007590 HflX GTPase family; Region: HflX; cd01878 1205676007591 G1 box; other site 1205676007592 GTP/Mg2+ binding site [chemical binding]; other site 1205676007593 Switch I region; other site 1205676007594 G2 box; other site 1205676007595 G3 box; other site 1205676007596 Switch II region; other site 1205676007597 G4 box; other site 1205676007598 G5 box; other site 1205676007599 diaminopimelate epimerase; Region: DapF; TIGR00652 1205676007600 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1205676007601 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1205676007602 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1205676007603 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1205676007604 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1205676007605 active site 1205676007606 metal binding site [ion binding]; metal-binding site 1205676007607 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1205676007608 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1205676007609 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1205676007610 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1205676007611 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1205676007612 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205676007613 FeS/SAM binding site; other site 1205676007614 TRAM domain; Region: TRAM; cl01282 1205676007615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205676007616 FeS/SAM binding site; other site 1205676007617 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 1205676007618 DNA recombination protein RecA; Reviewed; Region: recA; PRK09519 1205676007619 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1205676007620 hexamer interface [polypeptide binding]; other site 1205676007621 Walker A motif; other site 1205676007622 ATP binding site [chemical binding]; other site 1205676007623 Walker B motif; other site 1205676007624 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1205676007625 protein-splicing catalytic site; other site 1205676007626 thioester formation/cholesterol transfer; other site 1205676007627 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1205676007628 recA bacterial DNA recombination protein; Region: RecA; cl17211 1205676007629 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1205676007630 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1205676007631 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205676007632 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1205676007633 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1205676007634 PE family; Region: PE; pfam00934 1205676007635 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1205676007636 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1205676007637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205676007638 non-specific DNA binding site [nucleotide binding]; other site 1205676007639 salt bridge; other site 1205676007640 sequence-specific DNA binding site [nucleotide binding]; other site 1205676007641 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1205676007642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205676007643 Coenzyme A binding pocket [chemical binding]; other site 1205676007644 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1205676007645 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205676007646 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1205676007647 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1205676007648 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1205676007649 classical (c) SDRs; Region: SDR_c; cd05233 1205676007650 NAD(P) binding site [chemical binding]; other site 1205676007651 active site 1205676007652 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205676007653 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205676007654 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1205676007655 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205676007656 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1205676007657 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1205676007658 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1205676007659 dimer interface [polypeptide binding]; other site 1205676007660 active site 1205676007661 catalytic residue [active] 1205676007662 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1205676007663 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1205676007664 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1205676007665 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1205676007666 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 1205676007667 putative active site [active] 1205676007668 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1205676007669 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 1205676007670 putative active site [active] 1205676007671 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 1205676007672 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1205676007673 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1205676007674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1205676007675 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1205676007676 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1205676007677 folate binding site [chemical binding]; other site 1205676007678 NADP+ binding site [chemical binding]; other site 1205676007679 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1205676007680 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1205676007681 dimerization interface [polypeptide binding]; other site 1205676007682 active site 1205676007683 Dienelactone hydrolase family; Region: DLH; pfam01738 1205676007684 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1205676007685 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1205676007686 classical (c) SDRs; Region: SDR_c; cd05233 1205676007687 NAD(P) binding site [chemical binding]; other site 1205676007688 active site 1205676007689 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676007690 PPE family; Region: PPE; pfam00823 1205676007691 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676007692 PE family; Region: PE; pfam00934 1205676007693 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676007694 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676007695 PPE family; Region: PPE; pfam00823 1205676007696 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1205676007697 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1205676007698 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1205676007699 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1205676007700 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1205676007701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205676007702 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1205676007703 Coenzyme A binding pocket [chemical binding]; other site 1205676007704 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1205676007705 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1205676007706 FMN-binding pocket [chemical binding]; other site 1205676007707 flavin binding motif; other site 1205676007708 phosphate binding motif [ion binding]; other site 1205676007709 beta-alpha-beta structure motif; other site 1205676007710 NAD binding pocket [chemical binding]; other site 1205676007711 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205676007712 catalytic loop [active] 1205676007713 iron binding site [ion binding]; other site 1205676007714 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1205676007715 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1205676007716 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1205676007717 hydrophobic ligand binding site; other site 1205676007718 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1205676007719 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205676007720 putative DNA binding site [nucleotide binding]; other site 1205676007721 putative Zn2+ binding site [ion binding]; other site 1205676007722 AsnC family; Region: AsnC_trans_reg; pfam01037 1205676007723 alanine dehydrogenase; Region: alaDH; TIGR00518 1205676007724 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1205676007725 hexamer interface [polypeptide binding]; other site 1205676007726 ligand binding site [chemical binding]; other site 1205676007727 putative active site [active] 1205676007728 NAD(P) binding site [chemical binding]; other site 1205676007729 Nitronate monooxygenase; Region: NMO; pfam03060 1205676007730 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1205676007731 FMN binding site [chemical binding]; other site 1205676007732 substrate binding site [chemical binding]; other site 1205676007733 putative catalytic residue [active] 1205676007734 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1205676007735 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1205676007736 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1205676007737 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1205676007738 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1205676007739 oligomer interface [polypeptide binding]; other site 1205676007740 RNA binding site [nucleotide binding]; other site 1205676007741 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1205676007742 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1205676007743 RNase E interface [polypeptide binding]; other site 1205676007744 trimer interface [polypeptide binding]; other site 1205676007745 active site 1205676007746 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1205676007747 putative nucleic acid binding region [nucleotide binding]; other site 1205676007748 G-X-X-G motif; other site 1205676007749 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1205676007750 RNA binding site [nucleotide binding]; other site 1205676007751 domain interface; other site 1205676007752 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1205676007753 16S/18S rRNA binding site [nucleotide binding]; other site 1205676007754 S13e-L30e interaction site [polypeptide binding]; other site 1205676007755 25S rRNA binding site [nucleotide binding]; other site 1205676007756 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1205676007757 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1205676007758 active site 1205676007759 Riboflavin kinase; Region: Flavokinase; pfam01687 1205676007760 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1205676007761 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1205676007762 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1205676007763 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205676007764 putative DNA binding site [nucleotide binding]; other site 1205676007765 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1205676007766 FeoA domain; Region: FeoA; pfam04023 1205676007767 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676007768 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676007769 active site 1205676007770 lipid-transfer protein; Provisional; Region: PRK08256 1205676007771 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205676007772 active site 1205676007773 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1205676007774 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1205676007775 RNA binding site [nucleotide binding]; other site 1205676007776 active site 1205676007777 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1205676007778 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1205676007779 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1205676007780 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1205676007781 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1205676007782 active site 1205676007783 metal binding site [ion binding]; metal-binding site 1205676007784 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1205676007785 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 1205676007786 nucleophilic elbow; other site 1205676007787 catalytic triad; other site 1205676007788 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1205676007789 Predicted acyl esterases [General function prediction only]; Region: COG2936 1205676007790 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1205676007791 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1205676007792 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1205676007793 Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373 1205676007794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1205676007795 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15024109 1205676007796 Predicted ATPase [General function prediction only]; Region: COG3903 1205676007797 Predicted ATPase [General function prediction only]; Region: COG3903 1205676007798 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205676007799 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1205676007800 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205676007801 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205676007802 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205676007803 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1205676007804 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636 1205676007805 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09699 1205676007806 CRISPR system related protein, RAMP superfamily [Defense mechanisms]; Region: COG1332 1205676007807 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 1205676007808 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 1205676007809 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 1205676007810 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 1205676007811 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 1205676007812 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1205676007813 Integrase core domain; Region: rve; pfam00665 1205676007814 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 1205676007815 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1205676007816 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1205676007817 putative active site [active] 1205676007818 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205676007819 enoyl-CoA hydratase; Provisional; Region: PRK06190 1205676007820 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676007821 substrate binding site [chemical binding]; other site 1205676007822 oxyanion hole (OAH) forming residues; other site 1205676007823 trimer interface [polypeptide binding]; other site 1205676007824 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1205676007825 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1205676007826 Walker A/P-loop; other site 1205676007827 ATP binding site [chemical binding]; other site 1205676007828 Q-loop/lid; other site 1205676007829 ABC transporter signature motif; other site 1205676007830 Walker B; other site 1205676007831 D-loop; other site 1205676007832 H-loop/switch region; other site 1205676007833 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1205676007834 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1205676007835 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1205676007836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676007837 dimer interface [polypeptide binding]; other site 1205676007838 conserved gate region; other site 1205676007839 putative PBP binding loops; other site 1205676007840 ABC-ATPase subunit interface; other site 1205676007841 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1205676007842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676007843 dimer interface [polypeptide binding]; other site 1205676007844 conserved gate region; other site 1205676007845 putative PBP binding loops; other site 1205676007846 ABC-ATPase subunit interface; other site 1205676007847 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1205676007848 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1205676007849 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1205676007850 DHH family; Region: DHH; pfam01368 1205676007851 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1205676007852 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1205676007853 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1205676007854 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1205676007855 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1205676007856 G1 box; other site 1205676007857 putative GEF interaction site [polypeptide binding]; other site 1205676007858 GTP/Mg2+ binding site [chemical binding]; other site 1205676007859 Switch I region; other site 1205676007860 G2 box; other site 1205676007861 G3 box; other site 1205676007862 Switch II region; other site 1205676007863 G4 box; other site 1205676007864 G5 box; other site 1205676007865 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1205676007866 Translation-initiation factor 2; Region: IF-2; pfam11987 1205676007867 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1205676007868 Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740 1205676007869 putative RNA binding cleft [nucleotide binding]; other site 1205676007870 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1205676007871 NusA N-terminal domain; Region: NusA_N; pfam08529 1205676007872 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1205676007873 RNA binding site [nucleotide binding]; other site 1205676007874 homodimer interface [polypeptide binding]; other site 1205676007875 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1205676007876 G-X-X-G motif; other site 1205676007877 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1205676007878 G-X-X-G motif; other site 1205676007879 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1205676007880 Sm and related proteins; Region: Sm_like; cl00259 1205676007881 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1205676007882 putative oligomer interface [polypeptide binding]; other site 1205676007883 putative RNA binding site [nucleotide binding]; other site 1205676007884 Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718 1205676007885 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1205676007886 dinuclear metal binding motif [ion binding]; other site 1205676007887 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1205676007888 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1205676007889 dimer interface [polypeptide binding]; other site 1205676007890 motif 1; other site 1205676007891 active site 1205676007892 motif 2; other site 1205676007893 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1205676007894 putative deacylase active site [active] 1205676007895 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205676007896 active site 1205676007897 motif 3; other site 1205676007898 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1205676007899 anticodon binding site; other site 1205676007900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676007901 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205676007902 putative substrate translocation pore; other site 1205676007903 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1205676007904 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1205676007905 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1205676007906 homodimer interface [polypeptide binding]; other site 1205676007907 active site 1205676007908 SAM binding site [chemical binding]; other site 1205676007909 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1205676007910 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205676007911 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1205676007912 catalytic triad [active] 1205676007913 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1205676007914 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1205676007915 homodimer interface [polypeptide binding]; other site 1205676007916 Walker A motif; other site 1205676007917 ATP binding site [chemical binding]; other site 1205676007918 hydroxycobalamin binding site [chemical binding]; other site 1205676007919 Walker B motif; other site 1205676007920 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1205676007921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676007922 Walker A motif; other site 1205676007923 ATP binding site [chemical binding]; other site 1205676007924 Walker B motif; other site 1205676007925 arginine finger; other site 1205676007926 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1205676007927 metal ion-dependent adhesion site (MIDAS); other site 1205676007928 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 1205676007929 malate:quinone oxidoreductase; Validated; Region: PRK05257 1205676007930 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1205676007931 PE family; Region: PE; pfam00934 1205676007932 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1205676007933 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205676007934 mycothione reductase; Reviewed; Region: PRK07846 1205676007935 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205676007936 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205676007937 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205676007938 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1205676007939 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205676007940 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205676007941 short chain dehydrogenase; Provisional; Region: PRK06057 1205676007942 classical (c) SDRs; Region: SDR_c; cd05233 1205676007943 NAD(P) binding site [chemical binding]; other site 1205676007944 active site 1205676007945 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1205676007946 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1205676007947 NAD(P) binding site [chemical binding]; other site 1205676007948 catalytic residues [active] 1205676007949 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1205676007950 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1205676007951 catalytic triad [active] 1205676007952 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1205676007953 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1205676007954 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1205676007955 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1205676007956 active site 1205676007957 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1205676007958 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1205676007959 putative active site [active] 1205676007960 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1205676007961 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1205676007962 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1205676007963 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1205676007964 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1205676007965 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1205676007966 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1205676007967 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1205676007968 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1205676007969 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1205676007970 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1205676007971 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1205676007972 active site 1205676007973 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1205676007974 protein binding site [polypeptide binding]; other site 1205676007975 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1205676007976 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1205676007977 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1205676007978 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1205676007979 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205676007980 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205676007981 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1205676007982 Fasciclin domain; Region: Fasciclin; pfam02469 1205676007983 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1205676007984 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1205676007985 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1205676007986 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205676007987 catalytic residues [active] 1205676007988 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1205676007989 Fasciclin domain; Region: Fasciclin; pfam02469 1205676007990 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1205676007991 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1205676007992 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1205676007993 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205676007994 catalytic residues [active] 1205676007995 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1205676007996 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205676007997 FeS/SAM binding site; other site 1205676007998 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1205676007999 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1205676008000 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1205676008001 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1205676008002 hinge region; other site 1205676008003 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1205676008004 putative nucleotide binding site [chemical binding]; other site 1205676008005 uridine monophosphate binding site [chemical binding]; other site 1205676008006 homohexameric interface [polypeptide binding]; other site 1205676008007 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205676008008 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205676008009 DNA binding site [nucleotide binding] 1205676008010 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1205676008011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205676008012 Probable transposase; Region: OrfB_IS605; pfam01385 1205676008013 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1205676008014 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1205676008015 catalytic residues [active] 1205676008016 catalytic nucleophile [active] 1205676008017 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1205676008018 MarR family; Region: MarR; pfam01047 1205676008019 amidase; Provisional; Region: PRK07869 1205676008020 Amidase; Region: Amidase; pfam01425 1205676008021 elongation factor Ts; Provisional; Region: tsf; PRK09377 1205676008022 UBA/TS-N domain; Region: UBA; pfam00627 1205676008023 Elongation factor TS; Region: EF_TS; pfam00889 1205676008024 Elongation factor TS; Region: EF_TS; pfam00889 1205676008025 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1205676008026 rRNA interaction site [nucleotide binding]; other site 1205676008027 S8 interaction site; other site 1205676008028 putative laminin-1 binding site; other site 1205676008029 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1205676008030 Peptidase family M23; Region: Peptidase_M23; pfam01551 1205676008031 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676008032 PPE family; Region: PPE; pfam00823 1205676008033 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676008034 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1205676008035 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205676008036 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1205676008037 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205676008038 active site 1205676008039 DNA binding site [nucleotide binding] 1205676008040 Int/Topo IB signature motif; other site 1205676008041 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1205676008042 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1205676008043 FAD binding pocket [chemical binding]; other site 1205676008044 FAD binding motif [chemical binding]; other site 1205676008045 phosphate binding motif [ion binding]; other site 1205676008046 NAD binding pocket [chemical binding]; other site 1205676008047 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1205676008048 DNA protecting protein DprA; Region: dprA; TIGR00732 1205676008049 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1205676008050 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1205676008051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676008052 Walker A motif; other site 1205676008053 ATP binding site [chemical binding]; other site 1205676008054 Walker B motif; other site 1205676008055 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1205676008056 hypothetical protein; Reviewed; Region: PRK12497 1205676008057 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1205676008058 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1205676008059 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1205676008060 putative molybdopterin cofactor binding site [chemical binding]; other site 1205676008061 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1205676008062 putative molybdopterin cofactor binding site; other site 1205676008063 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1205676008064 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1205676008065 RNA/DNA hybrid binding site [nucleotide binding]; other site 1205676008066 active site 1205676008067 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1205676008068 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1205676008069 Catalytic site [active] 1205676008070 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1205676008071 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1205676008072 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1205676008073 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1205676008074 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1205676008075 RimM N-terminal domain; Region: RimM; pfam01782 1205676008076 hypothetical protein; Provisional; Region: PRK02821 1205676008077 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1205676008078 G-X-X-G motif; other site 1205676008079 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1205676008080 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1205676008081 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1205676008082 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1205676008083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676008084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676008085 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1205676008086 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1205676008087 active site 1205676008088 putative substrate binding pocket [chemical binding]; other site 1205676008089 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1205676008090 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205676008091 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205676008092 active site 1205676008093 ATP binding site [chemical binding]; other site 1205676008094 substrate binding site [chemical binding]; other site 1205676008095 activation loop (A-loop); other site 1205676008096 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1205676008097 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1205676008098 active site 1205676008099 signal recognition particle protein; Provisional; Region: PRK10867 1205676008100 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1205676008101 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1205676008102 P loop; other site 1205676008103 GTP binding site [chemical binding]; other site 1205676008104 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1205676008105 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1205676008106 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1205676008107 PII uridylyl-transferase; Provisional; Region: PRK03381 1205676008108 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1205676008109 metal binding triad; other site 1205676008110 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1205676008111 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205676008112 Zn2+ binding site [ion binding]; other site 1205676008113 Mg2+ binding site [ion binding]; other site 1205676008114 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1205676008115 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1205676008116 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1205676008117 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1205676008118 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1205676008119 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205676008120 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1205676008121 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1205676008122 Walker A/P-loop; other site 1205676008123 ATP binding site [chemical binding]; other site 1205676008124 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1205676008125 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1205676008126 ABC transporter signature motif; other site 1205676008127 Walker B; other site 1205676008128 D-loop; other site 1205676008129 H-loop/switch region; other site 1205676008130 acylphosphatase; Provisional; Region: PRK14422 1205676008131 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1205676008132 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1205676008133 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1205676008134 DNA binding site [nucleotide binding] 1205676008135 catalytic residue [active] 1205676008136 H2TH interface [polypeptide binding]; other site 1205676008137 putative catalytic residues [active] 1205676008138 turnover-facilitating residue; other site 1205676008139 intercalation triad [nucleotide binding]; other site 1205676008140 8OG recognition residue [nucleotide binding]; other site 1205676008141 putative reading head residues; other site 1205676008142 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1205676008143 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1205676008144 ribonuclease III; Reviewed; Region: rnc; PRK00102 1205676008145 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1205676008146 dimerization interface [polypeptide binding]; other site 1205676008147 active site 1205676008148 metal binding site [ion binding]; metal-binding site 1205676008149 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1205676008150 dsRNA binding site [nucleotide binding]; other site 1205676008151 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1205676008152 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1205676008153 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1205676008154 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1205676008155 acyl-CoA synthetase; Validated; Region: PRK05850 1205676008156 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205676008157 acyl-activating enzyme (AAE) consensus motif; other site 1205676008158 active site 1205676008159 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205676008160 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205676008161 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676008162 active site 1205676008163 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1205676008164 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205676008165 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1205676008166 NADP binding site [chemical binding]; other site 1205676008167 KR domain; Region: KR; pfam08659 1205676008168 active site 1205676008169 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676008170 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676008171 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205676008172 active site 1205676008173 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1205676008174 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1205676008175 KR domain; Region: KR; pfam08659 1205676008176 NADP binding site [chemical binding]; other site 1205676008177 active site 1205676008178 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676008179 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205676008180 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676008181 active site 1205676008182 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1205676008183 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205676008184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676008185 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205676008186 Enoylreductase; Region: PKS_ER; smart00829 1205676008187 NAD(P) binding site [chemical binding]; other site 1205676008188 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205676008189 KR domain; Region: KR; pfam08659 1205676008190 putative NADP binding site [chemical binding]; other site 1205676008191 active site 1205676008192 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676008193 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205676008194 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676008195 active site 1205676008196 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205676008197 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205676008198 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205676008199 KR domain; Region: KR; pfam08659 1205676008200 putative NADP binding site [chemical binding]; other site 1205676008201 active site 1205676008202 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676008203 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205676008204 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676008205 active site 1205676008206 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205676008207 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1205676008208 Condensation domain; Region: Condensation; pfam00668 1205676008209 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1205676008210 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205676008211 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1205676008212 Walker A/P-loop; other site 1205676008213 ATP binding site [chemical binding]; other site 1205676008214 Q-loop/lid; other site 1205676008215 ABC transporter signature motif; other site 1205676008216 Walker B; other site 1205676008217 D-loop; other site 1205676008218 H-loop/switch region; other site 1205676008219 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1205676008220 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1205676008221 ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025 1205676008222 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1205676008223 acyltransferase PapA5; Provisional; Region: PRK09294 1205676008224 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205676008225 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676008226 active site 1205676008227 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1205676008228 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205676008229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676008230 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205676008231 Enoylreductase; Region: PKS_ER; smart00829 1205676008232 NAD(P) binding site [chemical binding]; other site 1205676008233 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205676008234 KR domain; Region: KR; pfam08659 1205676008235 putative NADP binding site [chemical binding]; other site 1205676008236 active site 1205676008237 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676008238 acyl-CoA synthetase; Validated; Region: PRK05850 1205676008239 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205676008240 acyl-activating enzyme (AAE) consensus motif; other site 1205676008241 active site 1205676008242 MMPL family; Region: MMPL; pfam03176 1205676008243 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1205676008244 Erythronolide synthase docking; Region: Docking; pfam08990 1205676008245 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205676008246 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676008247 active site 1205676008248 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205676008249 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205676008250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676008251 Enoylreductase; Region: PKS_ER; smart00829 1205676008252 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205676008253 NAD(P) binding site [chemical binding]; other site 1205676008254 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1205676008255 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1205676008256 putative NADP binding site [chemical binding]; other site 1205676008257 active site 1205676008258 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676008259 acyl-CoA synthetase; Validated; Region: PRK06060 1205676008260 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676008261 acyl-activating enzyme (AAE) consensus motif; other site 1205676008262 AMP binding site [chemical binding]; other site 1205676008263 active site 1205676008264 CoA binding site [chemical binding]; other site 1205676008265 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676008266 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 1205676008267 acyl-CoA synthetase; Validated; Region: PRK05850 1205676008268 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205676008269 acyl-activating enzyme (AAE) consensus motif; other site 1205676008270 active site 1205676008271 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1205676008272 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205676008273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676008274 S-adenosylmethionine binding site [chemical binding]; other site 1205676008275 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1205676008276 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205676008277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676008278 S-adenosylmethionine binding site [chemical binding]; other site 1205676008279 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1205676008280 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1205676008281 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1205676008282 metal-binding site 1205676008283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1205676008284 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1205676008285 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205676008286 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205676008287 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1205676008288 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205676008289 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205676008290 active site 1205676008291 TDP-binding site; other site 1205676008292 acceptor substrate-binding pocket; other site 1205676008293 Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510 1205676008294 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1205676008295 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1205676008296 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1205676008297 active site 1205676008298 TDP-binding site; other site 1205676008299 acceptor substrate-binding pocket; other site 1205676008300 Predicted permease; Region: DUF318; pfam03773 1205676008301 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 1205676008302 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1205676008303 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1205676008304 putative active site [active] 1205676008305 putative substrate binding site [chemical binding]; other site 1205676008306 putative cosubstrate binding site; other site 1205676008307 catalytic site [active] 1205676008308 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1205676008309 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1205676008310 active site 1205676008311 (T/H)XGH motif; other site 1205676008312 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1205676008313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676008314 S-adenosylmethionine binding site [chemical binding]; other site 1205676008315 pyruvate carboxylase; Reviewed; Region: PRK12999 1205676008316 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205676008317 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205676008318 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1205676008319 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1205676008320 active site 1205676008321 catalytic residues [active] 1205676008322 metal binding site [ion binding]; metal-binding site 1205676008323 homodimer binding site [polypeptide binding]; other site 1205676008324 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205676008325 carboxyltransferase (CT) interaction site; other site 1205676008326 biotinylation site [posttranslational modification]; other site 1205676008327 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1205676008328 putative active site [active] 1205676008329 redox center [active] 1205676008330 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1205676008331 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1205676008332 catalytic residues [active] 1205676008333 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1205676008334 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205676008335 substrate binding pocket [chemical binding]; other site 1205676008336 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1205676008337 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1205676008338 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1205676008339 active site 1205676008340 catalytic tetrad [active] 1205676008341 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1205676008342 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 1205676008343 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1205676008344 generic binding surface II; other site 1205676008345 ssDNA binding site; other site 1205676008346 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205676008347 ATP binding site [chemical binding]; other site 1205676008348 putative Mg++ binding site [ion binding]; other site 1205676008349 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205676008350 nucleotide binding region [chemical binding]; other site 1205676008351 ATP-binding site [chemical binding]; other site 1205676008352 DAK2 domain; Region: Dak2; cl03685 1205676008353 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 1205676008354 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1205676008355 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1205676008356 ligand binding site [chemical binding]; other site 1205676008357 active site 1205676008358 UGI interface [polypeptide binding]; other site 1205676008359 catalytic site [active] 1205676008360 thiamine monophosphate kinase; Provisional; Region: PRK05731 1205676008361 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1205676008362 ATP binding site [chemical binding]; other site 1205676008363 dimerization interface [polypeptide binding]; other site 1205676008364 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1205676008365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205676008366 Probable transposase; Region: OrfB_IS605; pfam01385 1205676008367 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1205676008368 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 1205676008369 catalytic residues [active] 1205676008370 catalytic nucleophile [active] 1205676008371 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1205676008372 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1205676008373 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1205676008374 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1205676008375 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1205676008376 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1205676008377 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1205676008378 Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920 1205676008379 polyphosphate kinase; Provisional; Region: PRK05443 1205676008380 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1205676008381 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1205676008382 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1205676008383 putative domain interface [polypeptide binding]; other site 1205676008384 putative active site [active] 1205676008385 catalytic site [active] 1205676008386 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1205676008387 putative domain interface [polypeptide binding]; other site 1205676008388 putative active site [active] 1205676008389 catalytic site [active] 1205676008390 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1205676008391 active site 1205676008392 Ap6A binding site [chemical binding]; other site 1205676008393 nudix motif; other site 1205676008394 metal binding site [ion binding]; metal-binding site 1205676008395 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205676008396 catalytic core [active] 1205676008397 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1205676008398 IHF - DNA interface [nucleotide binding]; other site 1205676008399 IHF dimer interface [polypeptide binding]; other site 1205676008400 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1205676008401 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1205676008402 substrate binding site [chemical binding]; other site 1205676008403 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1205676008404 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1205676008405 substrate binding site [chemical binding]; other site 1205676008406 ligand binding site [chemical binding]; other site 1205676008407 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1205676008408 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1205676008409 Bacterial transcriptional regulator; Region: IclR; pfam01614 1205676008410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676008411 S-adenosylmethionine binding site [chemical binding]; other site 1205676008412 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1205676008413 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1205676008414 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1205676008415 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205676008416 active site 1205676008417 HIGH motif; other site 1205676008418 nucleotide binding site [chemical binding]; other site 1205676008419 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1205676008420 active site 1205676008421 KMSKS motif; other site 1205676008422 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1205676008423 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1205676008424 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1205676008425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676008426 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1205676008427 putative substrate translocation pore; other site 1205676008428 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1205676008429 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1205676008430 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1205676008431 ligand binding site [chemical binding]; other site 1205676008432 NAD binding site [chemical binding]; other site 1205676008433 dimerization interface [polypeptide binding]; other site 1205676008434 catalytic site [active] 1205676008435 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1205676008436 putative L-serine binding site [chemical binding]; other site 1205676008437 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1205676008438 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205676008439 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1205676008440 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1205676008441 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1205676008442 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1205676008443 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1205676008444 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1205676008445 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1205676008446 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1205676008447 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1205676008448 putative valine binding site [chemical binding]; other site 1205676008449 dimer interface [polypeptide binding]; other site 1205676008450 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1205676008451 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1205676008452 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205676008453 PYR/PP interface [polypeptide binding]; other site 1205676008454 dimer interface [polypeptide binding]; other site 1205676008455 TPP binding site [chemical binding]; other site 1205676008456 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205676008457 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1205676008458 TPP-binding site [chemical binding]; other site 1205676008459 dimer interface [polypeptide binding]; other site 1205676008460 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1205676008461 Predicted membrane protein [Function unknown]; Region: COG2259 1205676008462 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1205676008463 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1205676008464 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1205676008465 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1205676008466 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1205676008467 GatB domain; Region: GatB_Yqey; smart00845 1205676008468 6-phosphofructokinase; Provisional; Region: PRK03202 1205676008469 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1205676008470 active site 1205676008471 ADP/pyrophosphate binding site [chemical binding]; other site 1205676008472 dimerization interface [polypeptide binding]; other site 1205676008473 allosteric effector site; other site 1205676008474 fructose-1,6-bisphosphate binding site; other site 1205676008475 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1205676008476 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1205676008477 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 1205676008478 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1205676008479 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1205676008480 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1205676008481 nucleotide binding pocket [chemical binding]; other site 1205676008482 K-X-D-G motif; other site 1205676008483 catalytic site [active] 1205676008484 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1205676008485 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1205676008486 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1205676008487 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1205676008488 Dimer interface [polypeptide binding]; other site 1205676008489 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1205676008490 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205676008491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205676008492 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676008493 PPE family; Region: PPE; pfam00823 1205676008494 Integrase core domain; Region: rve; pfam00665 1205676008495 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1205676008496 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1205676008497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676008498 Walker A motif; other site 1205676008499 ATP binding site [chemical binding]; other site 1205676008500 Walker B motif; other site 1205676008501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205676008502 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676008503 PPE family; Region: PPE; pfam00823 1205676008504 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1205676008505 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1205676008506 Ligand Binding Site [chemical binding]; other site 1205676008507 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1205676008508 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1205676008509 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205676008510 catalytic residue [active] 1205676008511 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205676008512 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205676008513 putative acyl-acceptor binding pocket; other site 1205676008514 Putative hemolysin [General function prediction only]; Region: COG3176 1205676008515 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1205676008516 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1205676008517 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1205676008518 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1205676008519 Ligand binding site [chemical binding]; other site 1205676008520 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1205676008521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676008522 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205676008523 S-adenosylmethionine binding site [chemical binding]; other site 1205676008524 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1205676008525 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1205676008526 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1205676008527 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1205676008528 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1205676008529 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1205676008530 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1205676008531 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1205676008532 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1205676008533 trimer interface [polypeptide binding]; other site 1205676008534 active site 1205676008535 substrate binding site [chemical binding]; other site 1205676008536 CoA binding site [chemical binding]; other site 1205676008537 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1205676008538 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1205676008539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676008540 S-adenosylmethionine binding site [chemical binding]; other site 1205676008541 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676008542 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1205676008543 substrate binding site [chemical binding]; other site 1205676008544 oxyanion hole (OAH) forming residues; other site 1205676008545 trimer interface [polypeptide binding]; other site 1205676008546 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1205676008547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205676008548 Walker A/P-loop; other site 1205676008549 ATP binding site [chemical binding]; other site 1205676008550 Q-loop/lid; other site 1205676008551 ABC transporter signature motif; other site 1205676008552 Walker B; other site 1205676008553 D-loop; other site 1205676008554 H-loop/switch region; other site 1205676008555 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1205676008556 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1205676008557 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1205676008558 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205676008559 motif II; other site 1205676008560 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1205676008561 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1205676008562 D-pathway; other site 1205676008563 Putative ubiquinol binding site [chemical binding]; other site 1205676008564 Low-spin heme (heme b) binding site [chemical binding]; other site 1205676008565 Putative water exit pathway; other site 1205676008566 Binuclear center (heme o3/CuB) [ion binding]; other site 1205676008567 K-pathway; other site 1205676008568 Putative proton exit pathway; other site 1205676008569 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1205676008570 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1205676008571 siderophore binding site; other site 1205676008572 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1205676008573 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1205676008574 putative NAD(P) binding site [chemical binding]; other site 1205676008575 putative substrate binding site [chemical binding]; other site 1205676008576 catalytic Zn binding site [ion binding]; other site 1205676008577 structural Zn binding site [ion binding]; other site 1205676008578 dimer interface [polypeptide binding]; other site 1205676008579 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1205676008580 Phage capsid family; Region: Phage_capsid; pfam05065 1205676008581 Phage capsid family; Region: Phage_capsid; pfam05065 1205676008582 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1205676008583 Phage Terminase; Region: Terminase_1; pfam03354 1205676008584 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 1205676008585 Helix-turn-helix domain; Region: HTH_17; cl17695 1205676008586 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1205676008587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205676008588 non-specific DNA binding site [nucleotide binding]; other site 1205676008589 salt bridge; other site 1205676008590 sequence-specific DNA binding site [nucleotide binding]; other site 1205676008591 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205676008592 active site 1205676008593 DNA binding site [nucleotide binding] 1205676008594 Int/Topo IB signature motif; other site 1205676008595 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1205676008596 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1205676008597 dimer interface [polypeptide binding]; other site 1205676008598 putative radical transfer pathway; other site 1205676008599 diiron center [ion binding]; other site 1205676008600 tyrosyl radical; other site 1205676008601 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205676008602 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205676008603 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676008604 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676008605 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1205676008606 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1205676008607 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1205676008608 active site 1205676008609 dimer interface [polypeptide binding]; other site 1205676008610 catalytic residues [active] 1205676008611 effector binding site; other site 1205676008612 R2 peptide binding site; other site 1205676008613 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1205676008614 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1205676008615 catalytic residues [active] 1205676008616 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1205676008617 Predicted flavoprotein [General function prediction only]; Region: COG0431 1205676008618 DNA polymerase IV; Validated; Region: PRK03352 1205676008619 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1205676008620 active site 1205676008621 DNA binding site [nucleotide binding] 1205676008622 short chain dehydrogenase; Provisional; Region: PRK07832 1205676008623 classical (c) SDRs; Region: SDR_c; cd05233 1205676008624 NAD(P) binding site [chemical binding]; other site 1205676008625 active site 1205676008626 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676008627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676008628 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676008629 Cytochrome P450; Region: p450; cl12078 1205676008630 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205676008631 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205676008632 DNA-binding site [nucleotide binding]; DNA binding site 1205676008633 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1205676008634 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1205676008635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1205676008636 DNA-binding site [nucleotide binding]; DNA binding site 1205676008637 FCD domain; Region: FCD; pfam07729 1205676008638 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676008639 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205676008640 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676008641 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676008642 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676008643 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676008644 active site 1205676008645 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1205676008646 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1205676008647 active site 1205676008648 DNA binding site [nucleotide binding] 1205676008649 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1205676008650 DNA binding site [nucleotide binding] 1205676008651 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1205676008652 Carbon starvation protein CstA; Region: CstA; pfam02554 1205676008653 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1205676008654 Predicted membrane protein [Function unknown]; Region: COG2259 1205676008655 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1205676008656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1205676008657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676008658 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205676008659 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1205676008660 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1205676008661 active site 1205676008662 substrate binding site [chemical binding]; other site 1205676008663 metal binding site [ion binding]; metal-binding site 1205676008664 camphor resistance protein CrcB; Provisional; Region: PRK14216 1205676008665 camphor resistance protein CrcB; Provisional; Region: PRK14228 1205676008666 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1205676008667 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1205676008668 Uncharacterized ACR, COG1993; Region: DUF190; pfam02641 1205676008669 Transposase; Region: HTH_Tnp_1; pfam01527 1205676008670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205676008671 HTH-like domain; Region: HTH_21; pfam13276 1205676008672 Integrase core domain; Region: rve; pfam00665 1205676008673 Integrase core domain; Region: rve_3; pfam13683 1205676008674 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205676008675 Protein of unknown function, DUF488; Region: DUF488; cl01246 1205676008676 Protein of unknown function, DUF488; Region: DUF488; cl01246 1205676008677 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205676008678 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205676008679 active site 1205676008680 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1205676008681 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1205676008682 putative hydrophobic ligand binding site [chemical binding]; other site 1205676008683 protein interface [polypeptide binding]; other site 1205676008684 gate; other site 1205676008685 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1205676008686 Sulfatase; Region: Sulfatase; pfam00884 1205676008687 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1205676008688 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205676008689 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1205676008690 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1205676008691 active site 1205676008692 ATP binding site [chemical binding]; other site 1205676008693 substrate binding site [chemical binding]; other site 1205676008694 activation loop (A-loop); other site 1205676008695 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1205676008696 AAA ATPase domain; Region: AAA_16; pfam13191 1205676008697 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; pfam09970 1205676008698 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1205676008699 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205676008700 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205676008701 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205676008702 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205676008703 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1205676008704 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1205676008705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676008706 NAD(P) binding site [chemical binding]; other site 1205676008707 active site 1205676008708 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1205676008709 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1205676008710 NAD binding site [chemical binding]; other site 1205676008711 catalytic Zn binding site [ion binding]; other site 1205676008712 substrate binding site [chemical binding]; other site 1205676008713 structural Zn binding site [ion binding]; other site 1205676008714 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205676008715 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205676008716 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205676008717 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205676008718 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1205676008719 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1205676008720 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676008721 acyl-activating enzyme (AAE) consensus motif; other site 1205676008722 AMP binding site [chemical binding]; other site 1205676008723 active site 1205676008724 CoA binding site [chemical binding]; other site 1205676008725 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1205676008726 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1205676008727 Patatin-like phospholipase; Region: Patatin; pfam01734 1205676008728 Protein of unknown function (DUF808); Region: DUF808; cl01002 1205676008729 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1205676008730 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205676008731 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676008732 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676008733 active site 1205676008734 Predicted transcriptional regulators [Transcription]; Region: COG1733 1205676008735 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205676008736 dimerization interface [polypeptide binding]; other site 1205676008737 putative DNA binding site [nucleotide binding]; other site 1205676008738 putative Zn2+ binding site [ion binding]; other site 1205676008739 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1205676008740 PE family; Region: PE; pfam00934 1205676008741 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205676008742 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1205676008743 De-etiolated protein 1 Det1; Region: Det1; pfam09737 1205676008744 PemK-like protein; Region: PemK; pfam02452 1205676008745 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205676008746 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1205676008747 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1205676008748 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1205676008749 SmpB-tmRNA interface; other site 1205676008750 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1205676008751 FtsX-like permease family; Region: FtsX; pfam02687 1205676008752 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1205676008753 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1205676008754 Walker A/P-loop; other site 1205676008755 ATP binding site [chemical binding]; other site 1205676008756 Q-loop/lid; other site 1205676008757 ABC transporter signature motif; other site 1205676008758 Walker B; other site 1205676008759 D-loop; other site 1205676008760 H-loop/switch region; other site 1205676008761 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1205676008762 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1205676008763 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1205676008764 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1205676008765 RF-1 domain; Region: RF-1; pfam00472 1205676008766 ferredoxin-NADP+ reductase; Region: PLN02852 1205676008767 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205676008768 FAD binding domain; Region: FAD_binding_4; pfam01565 1205676008769 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 1205676008770 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205676008771 FeS/SAM binding site; other site 1205676008772 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1205676008773 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1205676008774 aromatic arch; other site 1205676008775 DCoH dimer interaction site [polypeptide binding]; other site 1205676008776 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1205676008777 DCoH tetramer interaction site [polypeptide binding]; other site 1205676008778 substrate binding site [chemical binding]; other site 1205676008779 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205676008780 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1205676008781 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205676008782 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205676008783 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205676008784 dimer interface [polypeptide binding]; other site 1205676008785 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1205676008786 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1205676008787 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1205676008788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1205676008789 Histidine kinase; Region: HisKA_3; pfam07730 1205676008790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205676008791 ATP binding site [chemical binding]; other site 1205676008792 Mg2+ binding site [ion binding]; other site 1205676008793 G-X-G motif; other site 1205676008794 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1205676008795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205676008796 active site 1205676008797 phosphorylation site [posttranslational modification] 1205676008798 intermolecular recognition site; other site 1205676008799 dimerization interface [polypeptide binding]; other site 1205676008800 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1205676008801 DNA binding residues [nucleotide binding] 1205676008802 dimerization interface [polypeptide binding]; other site 1205676008803 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1205676008804 Ligand Binding Site [chemical binding]; other site 1205676008805 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676008806 PPE family; Region: PPE; pfam00823 1205676008807 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676008808 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676008809 PPE family; Region: PPE; pfam00823 1205676008810 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676008811 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1205676008812 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1205676008813 active site 1205676008814 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1205676008815 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205676008816 FeS/SAM binding site; other site 1205676008817 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676008818 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676008819 active site 1205676008820 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676008821 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676008822 active site 1205676008823 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1205676008824 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1205676008825 NAD(P) binding site [chemical binding]; other site 1205676008826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205676008827 active site 1205676008828 phosphorylation site [posttranslational modification] 1205676008829 intermolecular recognition site; other site 1205676008830 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676008831 PPE family; Region: PPE; pfam00823 1205676008832 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1205676008833 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1205676008834 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1205676008835 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1205676008836 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1205676008837 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1205676008838 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1205676008839 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1205676008840 putative dimer interface [polypeptide binding]; other site 1205676008841 [2Fe-2S] cluster binding site [ion binding]; other site 1205676008842 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1205676008843 SLBB domain; Region: SLBB; pfam10531 1205676008844 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1205676008845 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1205676008846 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205676008847 catalytic loop [active] 1205676008848 iron binding site [ion binding]; other site 1205676008849 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1205676008850 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1205676008851 molybdopterin cofactor binding site; other site 1205676008852 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1205676008853 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1205676008854 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1205676008855 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1205676008856 4Fe-4S binding domain; Region: Fer4; pfam00037 1205676008857 4Fe-4S binding domain; Region: Fer4; pfam00037 1205676008858 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1205676008859 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1205676008860 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1205676008861 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1205676008862 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205676008863 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1205676008864 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205676008865 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1205676008866 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1205676008867 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676008868 PPE family; Region: PPE; pfam00823 1205676008869 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676008870 PPE family; Region: PPE; pfam00823 1205676008871 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1205676008872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676008873 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1205676008874 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1205676008875 [2Fe-2S] cluster binding site [ion binding]; other site 1205676008876 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 1205676008877 putative alpha subunit interface [polypeptide binding]; other site 1205676008878 putative active site [active] 1205676008879 putative substrate binding site [chemical binding]; other site 1205676008880 Fe binding site [ion binding]; other site 1205676008881 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1205676008882 Protein of unknown function DUF58; Region: DUF58; pfam01882 1205676008883 MoxR-like ATPases [General function prediction only]; Region: COG0714 1205676008884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676008885 Walker A motif; other site 1205676008886 ATP binding site [chemical binding]; other site 1205676008887 Walker B motif; other site 1205676008888 arginine finger; other site 1205676008889 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1205676008890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676008891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676008892 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1205676008893 putative active site [active] 1205676008894 putative substrate binding site [chemical binding]; other site 1205676008895 ATP binding site [chemical binding]; other site 1205676008896 Phosphotransferase enzyme family; Region: APH; pfam01636 1205676008897 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1205676008898 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205676008899 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1205676008900 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676008901 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205676008902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676008903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676008904 short chain dehydrogenase; Validated; Region: PRK08264 1205676008905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676008906 NAD(P) binding site [chemical binding]; other site 1205676008907 active site 1205676008908 amidase; Provisional; Region: PRK06170 1205676008909 Amidase; Region: Amidase; pfam01425 1205676008910 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676008911 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676008912 TAP-like protein; Region: Abhydrolase_4; pfam08386 1205676008913 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205676008914 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1205676008915 AAA domain; Region: AAA_14; pfam13173 1205676008916 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1205676008917 putative active site [active] 1205676008918 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205676008919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683 1205676008920 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1205676008921 non-specific DNA binding site [nucleotide binding]; other site 1205676008922 salt bridge; other site 1205676008923 sequence-specific DNA binding site [nucleotide binding]; other site 1205676008924 RES domain; Region: RES; cl02411 1205676008925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205676008926 Transposase; Region: HTH_Tnp_1; cl17663 1205676008927 putative transposase OrfB; Reviewed; Region: PHA02517 1205676008928 HTH-like domain; Region: HTH_21; pfam13276 1205676008929 Integrase core domain; Region: rve; pfam00665 1205676008930 Integrase core domain; Region: rve_3; pfam13683 1205676008931 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1205676008932 Helix-turn-helix domain; Region: HTH_38; pfam13936 1205676008933 Integrase core domain; Region: rve; pfam00665 1205676008934 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1205676008935 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205676008936 hypothetical protein; Validated; Region: PRK00068 1205676008937 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1205676008938 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1205676008939 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1205676008940 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1205676008941 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1205676008942 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1205676008943 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1205676008944 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1205676008945 ABC1 family; Region: ABC1; pfam03109 1205676008946 Phosphotransferase enzyme family; Region: APH; pfam01636 1205676008947 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1205676008948 active site 1205676008949 ATP binding site [chemical binding]; other site 1205676008950 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1205676008951 Part of AAA domain; Region: AAA_19; pfam13245 1205676008952 Family description; Region: UvrD_C_2; pfam13538 1205676008953 HRDC domain; Region: HRDC; pfam00570 1205676008954 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1205676008955 catalytic residues [active] 1205676008956 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1205676008957 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1205676008958 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1205676008959 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1205676008960 putative NADH binding site [chemical binding]; other site 1205676008961 putative active site [active] 1205676008962 nudix motif; other site 1205676008963 putative metal binding site [ion binding]; other site 1205676008964 Ion channel; Region: Ion_trans_2; pfam07885 1205676008965 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1205676008966 TrkA-N domain; Region: TrkA_N; pfam02254 1205676008967 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1205676008968 Part of AAA domain; Region: AAA_19; pfam13245 1205676008969 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1205676008970 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1205676008971 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1205676008972 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1205676008973 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1205676008974 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205676008975 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1205676008976 active site 1205676008977 DNA binding site [nucleotide binding] 1205676008978 TIGR02569 family protein; Region: TIGR02569_actnb 1205676008979 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1205676008980 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1205676008981 ATP binding site [chemical binding]; other site 1205676008982 substrate interface [chemical binding]; other site 1205676008983 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1205676008984 active site residue [active] 1205676008985 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1205676008986 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676008987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676008988 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1205676008989 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 1205676008990 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1205676008991 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1205676008992 ATP binding site [chemical binding]; other site 1205676008993 Mg++ binding site [ion binding]; other site 1205676008994 motif III; other site 1205676008995 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205676008996 nucleotide binding region [chemical binding]; other site 1205676008997 ATP-binding site [chemical binding]; other site 1205676008998 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1205676008999 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205676009000 P-loop; other site 1205676009001 Magnesium ion binding site [ion binding]; other site 1205676009002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205676009003 Magnesium ion binding site [ion binding]; other site 1205676009004 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205676009005 catalytic core [active] 1205676009006 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1205676009007 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1205676009008 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1205676009009 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1205676009010 Transcription factor WhiB; Region: Whib; pfam02467 1205676009011 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1205676009012 PAS domain S-box; Region: sensory_box; TIGR00229 1205676009013 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1205676009014 Histidine kinase; Region: HisKA_2; pfam07568 1205676009015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205676009016 ATP binding site [chemical binding]; other site 1205676009017 Mg2+ binding site [ion binding]; other site 1205676009018 G-X-G motif; other site 1205676009019 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205676009020 carboxyltransferase (CT) interaction site; other site 1205676009021 biotinylation site [posttranslational modification]; other site 1205676009022 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1205676009023 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1205676009024 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205676009025 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205676009026 DNA binding residues [nucleotide binding] 1205676009027 short chain dehydrogenase; Provisional; Region: PRK08278 1205676009028 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1205676009029 NAD(P) binding site [chemical binding]; other site 1205676009030 homodimer interface [polypeptide binding]; other site 1205676009031 active site 1205676009032 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1205676009033 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1205676009034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1205676009035 Coenzyme A binding pocket [chemical binding]; other site 1205676009036 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1205676009037 Phosphotransferase enzyme family; Region: APH; pfam01636 1205676009038 putative active site [active] 1205676009039 putative substrate binding site [chemical binding]; other site 1205676009040 ATP binding site [chemical binding]; other site 1205676009041 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1205676009042 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1205676009043 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1205676009044 hinge; other site 1205676009045 active site 1205676009046 Predicted GTPases [General function prediction only]; Region: COG1162 1205676009047 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1205676009048 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1205676009049 GTP/Mg2+ binding site [chemical binding]; other site 1205676009050 G4 box; other site 1205676009051 G5 box; other site 1205676009052 G1 box; other site 1205676009053 Switch I region; other site 1205676009054 G2 box; other site 1205676009055 G3 box; other site 1205676009056 Switch II region; other site 1205676009057 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1205676009058 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1205676009059 putative di-iron ligands [ion binding]; other site 1205676009060 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1205676009061 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1205676009062 FAD binding pocket [chemical binding]; other site 1205676009063 FAD binding motif [chemical binding]; other site 1205676009064 phosphate binding motif [ion binding]; other site 1205676009065 beta-alpha-beta structure motif; other site 1205676009066 NAD binding pocket [chemical binding]; other site 1205676009067 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205676009068 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1205676009069 catalytic loop [active] 1205676009070 iron binding site [ion binding]; other site 1205676009071 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1205676009072 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205676009073 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205676009074 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1205676009075 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1205676009076 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1205676009077 TrkA-C domain; Region: TrkA_C; pfam02080 1205676009078 Phospholipid methyltransferase; Region: PEMT; cl17370 1205676009079 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1205676009080 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1205676009081 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205676009082 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1205676009083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676009084 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205676009085 putative substrate translocation pore; other site 1205676009086 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205676009087 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205676009088 ligand binding site [chemical binding]; other site 1205676009089 flexible hinge region; other site 1205676009090 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1205676009091 nucleophile elbow; other site 1205676009092 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1205676009093 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1205676009094 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1205676009095 30S subunit binding site; other site 1205676009096 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1205676009097 active site 1205676009098 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1205676009099 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1205676009100 lipoprotein LpqB; Provisional; Region: PRK13616 1205676009101 Sporulation and spore germination; Region: Germane; pfam10646 1205676009102 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1205676009103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205676009104 dimerization interface [polypeptide binding]; other site 1205676009105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205676009106 dimer interface [polypeptide binding]; other site 1205676009107 phosphorylation site [posttranslational modification] 1205676009108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205676009109 ATP binding site [chemical binding]; other site 1205676009110 Mg2+ binding site [ion binding]; other site 1205676009111 G-X-G motif; other site 1205676009112 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205676009113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205676009114 active site 1205676009115 phosphorylation site [posttranslational modification] 1205676009116 intermolecular recognition site; other site 1205676009117 dimerization interface [polypeptide binding]; other site 1205676009118 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205676009119 DNA binding site [nucleotide binding] 1205676009120 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1205676009121 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1205676009122 TMP-binding site; other site 1205676009123 ATP-binding site [chemical binding]; other site 1205676009124 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1205676009125 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1205676009126 homotetramer interface [polypeptide binding]; other site 1205676009127 ligand binding site [chemical binding]; other site 1205676009128 catalytic site [active] 1205676009129 NAD binding site [chemical binding]; other site 1205676009130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676009131 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1205676009132 Rubredoxin [Energy production and conversion]; Region: COG1773 1205676009133 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1205676009134 iron binding site [ion binding]; other site 1205676009135 Rubredoxin [Energy production and conversion]; Region: COG1773 1205676009136 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1205676009137 iron binding site [ion binding]; other site 1205676009138 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1205676009139 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1205676009140 Di-iron ligands [ion binding]; other site 1205676009141 amino acid transporter; Region: 2A0306; TIGR00909 1205676009142 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1205676009143 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1205676009144 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1205676009145 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1205676009146 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1205676009147 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1205676009148 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1205676009149 active site 1205676009150 substrate binding site [chemical binding]; other site 1205676009151 metal binding site [ion binding]; metal-binding site 1205676009152 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1205676009153 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1205676009154 Transcription factor WhiB; Region: Whib; pfam02467 1205676009155 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1205676009156 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 1205676009157 phosphate binding site [ion binding]; other site 1205676009158 dimer interface [polypeptide binding]; other site 1205676009159 substrate binding site [chemical binding]; other site 1205676009160 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1205676009161 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1205676009162 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1205676009163 putative FMN binding site [chemical binding]; other site 1205676009164 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1205676009165 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1205676009166 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1205676009167 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1205676009168 active site 1205676009169 Substrate binding site; other site 1205676009170 Mg++ binding site; other site 1205676009171 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1205676009172 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1205676009173 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1205676009174 Probable Catalytic site; other site 1205676009175 metal-binding site 1205676009176 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 1205676009177 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1205676009178 NADP binding site [chemical binding]; other site 1205676009179 active site 1205676009180 putative substrate binding site [chemical binding]; other site 1205676009181 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1205676009182 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205676009183 TIGR03089 family protein; Region: TIGR03089 1205676009184 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1205676009185 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1205676009186 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205676009187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1205676009188 active site 1205676009189 motif I; other site 1205676009190 motif II; other site 1205676009191 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1205676009192 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205676009193 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205676009194 active site 1205676009195 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205676009196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205676009197 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1205676009198 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1205676009199 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1205676009200 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1205676009201 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1205676009202 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 1205676009203 active site clefts [active] 1205676009204 zinc binding site [ion binding]; other site 1205676009205 dimer interface [polypeptide binding]; other site 1205676009206 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676009207 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1205676009208 FAD binding site [chemical binding]; other site 1205676009209 homotetramer interface [polypeptide binding]; other site 1205676009210 substrate binding pocket [chemical binding]; other site 1205676009211 catalytic base [active] 1205676009212 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1205676009213 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 1205676009214 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1205676009215 Predicted membrane protein [Function unknown]; Region: COG2246 1205676009216 GtrA-like protein; Region: GtrA; pfam04138 1205676009217 Bacterial PH domain; Region: DUF304; pfam03703 1205676009218 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1205676009219 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1205676009220 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1205676009221 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205676009222 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1205676009223 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205676009224 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 1205676009225 Maf-like protein; Region: Maf; pfam02545 1205676009226 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1205676009227 active site 1205676009228 dimer interface [polypeptide binding]; other site 1205676009229 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1205676009230 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1205676009231 active site residue [active] 1205676009232 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1205676009233 active site residue [active] 1205676009234 Fe-S metabolism associated domain; Region: SufE; pfam02657 1205676009235 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1205676009236 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1205676009237 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1205676009238 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1205676009239 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1205676009240 carboxyltransferase (CT) interaction site; other site 1205676009241 biotinylation site [posttranslational modification]; other site 1205676009242 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1205676009243 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205676009244 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1205676009245 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1205676009246 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1205676009247 L-lysine aminotransferase; Provisional; Region: PRK08297 1205676009248 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205676009249 inhibitor-cofactor binding pocket; inhibition site 1205676009250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676009251 catalytic residue [active] 1205676009252 putative DNA binding site [nucleotide binding]; other site 1205676009253 dimerization interface [polypeptide binding]; other site 1205676009254 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1205676009255 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1205676009256 putative Zn2+ binding site [ion binding]; other site 1205676009257 AsnC family; Region: AsnC_trans_reg; pfam01037 1205676009258 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1205676009259 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1205676009260 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1205676009261 tetrameric interface [polypeptide binding]; other site 1205676009262 NAD binding site [chemical binding]; other site 1205676009263 catalytic residues [active] 1205676009264 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1205676009265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676009266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676009267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205676009268 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1205676009269 ATP binding site [chemical binding]; other site 1205676009270 putative Mg++ binding site [ion binding]; other site 1205676009271 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205676009272 nucleotide binding region [chemical binding]; other site 1205676009273 ATP-binding site [chemical binding]; other site 1205676009274 DEAD/H associated; Region: DEAD_assoc; pfam08494 1205676009275 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1205676009276 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1205676009277 putative DNA binding site [nucleotide binding]; other site 1205676009278 catalytic residue [active] 1205676009279 putative H2TH interface [polypeptide binding]; other site 1205676009280 putative catalytic residues [active] 1205676009281 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1205676009282 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1205676009283 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1205676009284 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1205676009285 Sulfatase; Region: Sulfatase; pfam00884 1205676009286 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1205676009287 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1205676009288 probable active site [active] 1205676009289 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1205676009290 PhoU domain; Region: PhoU; pfam01895 1205676009291 PhoU domain; Region: PhoU; pfam01895 1205676009292 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1205676009293 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1205676009294 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205676009295 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1205676009296 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1205676009297 putative active site pocket [active] 1205676009298 dimerization interface [polypeptide binding]; other site 1205676009299 putative catalytic residue [active] 1205676009300 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1205676009301 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1205676009302 metal binding site [ion binding]; metal-binding site 1205676009303 putative dimer interface [polypeptide binding]; other site 1205676009304 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1205676009305 amidohydrolase; Region: amidohydrolases; TIGR01891 1205676009306 metal binding site [ion binding]; metal-binding site 1205676009307 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1205676009308 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15525680; Product type pe : putative enzyme 1205676009309 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15525680; Product type pe : putative enzyme 1205676009310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205676009311 active site 1205676009312 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1205676009313 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676009314 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1205676009315 adenosine deaminase; Provisional; Region: PRK09358 1205676009316 active site 1205676009317 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1205676009318 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1205676009319 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1205676009320 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1205676009321 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1205676009322 active site 1205676009323 catalytic motif [active] 1205676009324 Zn binding site [ion binding]; other site 1205676009325 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1205676009326 putative Iron-sulfur protein interface [polypeptide binding]; other site 1205676009327 putative proximal heme binding site [chemical binding]; other site 1205676009328 putative SdhD-like interface [polypeptide binding]; other site 1205676009329 putative distal heme binding site [chemical binding]; other site 1205676009330 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1205676009331 putative Iron-sulfur protein interface [polypeptide binding]; other site 1205676009332 putative proximal heme binding site [chemical binding]; other site 1205676009333 putative SdhC-like subunit interface [polypeptide binding]; other site 1205676009334 putative distal heme binding site [chemical binding]; other site 1205676009335 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1205676009336 L-aspartate oxidase; Provisional; Region: PRK06175 1205676009337 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1205676009338 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1205676009339 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1205676009340 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205676009341 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1205676009342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676009343 S-adenosylmethionine binding site [chemical binding]; other site 1205676009344 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1205676009345 MoaE interaction surface [polypeptide binding]; other site 1205676009346 MoeB interaction surface [polypeptide binding]; other site 1205676009347 thiocarboxylated glycine; other site 1205676009348 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1205676009349 MoaE homodimer interface [polypeptide binding]; other site 1205676009350 MoaD interaction [polypeptide binding]; other site 1205676009351 active site residues [active] 1205676009352 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1205676009353 trimer interface [polypeptide binding]; other site 1205676009354 dimer interface [polypeptide binding]; other site 1205676009355 putative active site [active] 1205676009356 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1205676009357 aromatic arch; other site 1205676009358 DCoH dimer interaction site [polypeptide binding]; other site 1205676009359 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1205676009360 DCoH tetramer interaction site [polypeptide binding]; other site 1205676009361 substrate binding site [chemical binding]; other site 1205676009362 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 1205676009363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205676009364 FeS/SAM binding site; other site 1205676009365 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1205676009366 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1205676009367 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1205676009368 DNA binding site [nucleotide binding] 1205676009369 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205676009370 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205676009371 phosphopeptide binding site; other site 1205676009372 Condensation domain; Region: Condensation; pfam00668 1205676009373 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1205676009374 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1205676009375 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205676009376 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205676009377 DNA binding residues [nucleotide binding] 1205676009378 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205676009379 hypothetical protein; Provisional; Region: PRK06541 1205676009380 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1205676009381 inhibitor-cofactor binding pocket; inhibition site 1205676009382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676009383 catalytic residue [active] 1205676009384 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1205676009385 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1205676009386 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1205676009387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676009388 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1205676009389 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1205676009390 active site 1205676009391 dimer interface [polypeptide binding]; other site 1205676009392 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205676009393 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1205676009394 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1205676009395 DNA binding residues [nucleotide binding] 1205676009396 dimer interface [polypeptide binding]; other site 1205676009397 metal binding site [ion binding]; metal-binding site 1205676009398 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1205676009399 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1205676009400 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1205676009401 active site 1205676009402 HIGH motif; other site 1205676009403 dimer interface [polypeptide binding]; other site 1205676009404 KMSKS motif; other site 1205676009405 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676009406 isocitrate dehydrogenase; Validated; Region: PRK08299 1205676009407 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1205676009408 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1205676009409 homodimer interface [polypeptide binding]; other site 1205676009410 substrate-cofactor binding pocket; other site 1205676009411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676009412 catalytic residue [active] 1205676009413 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1205676009414 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1205676009415 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205676009416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676009417 S-adenosylmethionine binding site [chemical binding]; other site 1205676009418 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009419 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009420 PPE family; Region: PPE; pfam00823 1205676009421 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009422 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009423 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009424 PE family; Region: PE; pfam00934 1205676009425 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1205676009426 PPE family; Region: PPE; pfam00823 1205676009427 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009428 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009429 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009430 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009431 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009432 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009433 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009434 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009435 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009436 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009437 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009438 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009439 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205676009440 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009441 PPE family; Region: PPE; pfam00823 1205676009442 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009443 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009444 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009445 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009446 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009447 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009448 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009449 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009450 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009451 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009452 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009453 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009454 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009455 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009456 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009457 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009458 Berberine and berberine like; Region: BBE; pfam08031 1205676009459 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205676009460 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1205676009461 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1205676009462 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1205676009463 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1205676009464 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1205676009465 homodimer interface [polypeptide binding]; other site 1205676009466 NADP binding site [chemical binding]; other site 1205676009467 substrate binding site [chemical binding]; other site 1205676009468 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1205676009469 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1205676009470 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205676009471 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme 1205676009472 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205676009473 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1205676009474 phosphopeptide binding site; other site 1205676009475 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1205676009476 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1205676009477 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1205676009478 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1205676009479 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1205676009480 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1205676009481 G1 box; other site 1205676009482 GTP/Mg2+ binding site [chemical binding]; other site 1205676009483 G2 box; other site 1205676009484 Switch I region; other site 1205676009485 G3 box; other site 1205676009486 Switch II region; other site 1205676009487 G4 box; other site 1205676009488 G5 box; other site 1205676009489 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1205676009490 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1205676009491 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205676009492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205676009493 ATP binding site [chemical binding]; other site 1205676009494 Mg2+ binding site [ion binding]; other site 1205676009495 G-X-G motif; other site 1205676009496 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1205676009497 PE family; Region: PE; pfam00934 1205676009498 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1205676009499 FMN binding site [chemical binding]; other site 1205676009500 dimer interface [polypeptide binding]; other site 1205676009501 PPOX class probable F420-dependent enzyme, Rv3369 family; Region: Rv3369; TIGR03667 1205676009502 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1205676009503 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1205676009504 active site 1205676009505 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1205676009506 generic binding surface II; other site 1205676009507 generic binding surface I; other site 1205676009508 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205676009509 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205676009510 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1205676009511 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1205676009512 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205676009513 active site 1205676009514 motif I; other site 1205676009515 motif II; other site 1205676009516 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1205676009517 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676009518 substrate binding site [chemical binding]; other site 1205676009519 oxyanion hole (OAH) forming residues; other site 1205676009520 trimer interface [polypeptide binding]; other site 1205676009521 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1205676009522 Amidase; Region: Amidase; pfam01425 1205676009523 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1205676009524 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205676009525 motif II; other site 1205676009526 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1205676009527 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1205676009528 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1205676009529 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1205676009530 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1205676009531 TPP-binding site [chemical binding]; other site 1205676009532 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1205676009533 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1205676009534 PYR/PP interface [polypeptide binding]; other site 1205676009535 dimer interface [polypeptide binding]; other site 1205676009536 TPP binding site [chemical binding]; other site 1205676009537 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1205676009538 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1205676009539 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1205676009540 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205676009541 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205676009542 substrate binding pocket [chemical binding]; other site 1205676009543 chain length determination region; other site 1205676009544 substrate-Mg2+ binding site; other site 1205676009545 catalytic residues [active] 1205676009546 aspartate-rich region 1; other site 1205676009547 active site lid residues [active] 1205676009548 aspartate-rich region 2; other site 1205676009549 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1205676009550 putative active site [active] 1205676009551 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205676009552 enoyl-CoA hydratase; Region: PLN02864 1205676009553 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205676009554 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1205676009555 dimer interaction site [polypeptide binding]; other site 1205676009556 substrate-binding tunnel; other site 1205676009557 active site 1205676009558 catalytic site [active] 1205676009559 substrate binding site [chemical binding]; other site 1205676009560 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205676009561 short chain dehydrogenase; Provisional; Region: PRK07201 1205676009562 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1205676009563 putative NAD(P) binding site [chemical binding]; other site 1205676009564 active site 1205676009565 putative substrate binding site [chemical binding]; other site 1205676009566 classical (c) SDRs; Region: SDR_c; cd05233 1205676009567 NAD(P) binding site [chemical binding]; other site 1205676009568 active site 1205676009569 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205676009570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676009571 S-adenosylmethionine binding site [chemical binding]; other site 1205676009572 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1205676009573 active site 1205676009574 DNA Polymerase Y-family; Region: PolY_like; cd03468 1205676009575 DNA binding site [nucleotide binding] 1205676009576 GMP synthase; Reviewed; Region: guaA; PRK00074 1205676009577 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1205676009578 AMP/PPi binding site [chemical binding]; other site 1205676009579 candidate oxyanion hole; other site 1205676009580 catalytic triad [active] 1205676009581 potential glutamine specificity residues [chemical binding]; other site 1205676009582 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1205676009583 ATP Binding subdomain [chemical binding]; other site 1205676009584 Ligand Binding sites [chemical binding]; other site 1205676009585 Dimerization subdomain; other site 1205676009586 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1205676009587 active site lid residues [active] 1205676009588 substrate binding pocket [chemical binding]; other site 1205676009589 catalytic residues [active] 1205676009590 substrate-Mg2+ binding site; other site 1205676009591 aspartate-rich region 1; other site 1205676009592 aspartate-rich region 2; other site 1205676009593 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1205676009594 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1205676009595 substrate binding pocket [chemical binding]; other site 1205676009596 chain length determination region; other site 1205676009597 substrate-Mg2+ binding site; other site 1205676009598 catalytic residues [active] 1205676009599 aspartate-rich region 1; other site 1205676009600 active site lid residues [active] 1205676009601 aspartate-rich region 2; other site 1205676009602 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205676009603 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205676009604 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1205676009605 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1205676009606 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1205676009607 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1205676009608 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1205676009609 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1205676009610 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1205676009611 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205676009612 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205676009613 catalytic residue [active] 1205676009614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1205676009615 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205676009616 hypothetical protein; Provisional; Region: PRK07579 1205676009617 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1205676009618 active site 1205676009619 cosubstrate binding site; other site 1205676009620 substrate binding site [chemical binding]; other site 1205676009621 catalytic site [active] 1205676009622 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676009623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676009624 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1205676009625 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1205676009626 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1205676009627 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 1205676009628 putative active site [active] 1205676009629 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1205676009630 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205676009631 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1205676009632 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1205676009633 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205676009634 phosphate binding site [ion binding]; other site 1205676009635 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1205676009636 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1205676009637 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1205676009638 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1205676009639 active site 1205676009640 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1205676009641 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205676009642 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205676009643 DNA binding residues [nucleotide binding] 1205676009644 Transcription factor WhiB; Region: Whib; pfam02467 1205676009645 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1205676009646 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1205676009647 ring oligomerisation interface [polypeptide binding]; other site 1205676009648 ATP/Mg binding site [chemical binding]; other site 1205676009649 stacking interactions; other site 1205676009650 hinge regions; other site 1205676009651 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1205676009652 oligomerisation interface [polypeptide binding]; other site 1205676009653 mobile loop; other site 1205676009654 roof hairpin; other site 1205676009655 UGMP family protein; Validated; Region: PRK09604 1205676009656 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1205676009657 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1205676009658 Coenzyme A binding pocket [chemical binding]; other site 1205676009659 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1205676009660 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1205676009661 alanine racemase; Reviewed; Region: alr; PRK00053 1205676009662 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1205676009663 active site 1205676009664 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1205676009665 dimer interface [polypeptide binding]; other site 1205676009666 substrate binding site [chemical binding]; other site 1205676009667 catalytic residues [active] 1205676009668 Evidence 4 : Homologs of previously reported genes of unknown function 1205676009669 Evidence 4 : Homologs of previously reported genes of unknown function 1205676009670 PPE family; Region: PPE; pfam00823 1205676009671 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009672 PPE family; Region: PPE; pfam00823 1205676009673 Evidence 4 : Homologs of previously reported genes of unknown function 1205676009674 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009675 PPE family; Region: PPE; pfam00823 1205676009676 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1205676009677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676009678 Walker A motif; other site 1205676009679 ATP binding site [chemical binding]; other site 1205676009680 Walker B motif; other site 1205676009681 arginine finger; other site 1205676009682 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009683 PPE family; Region: PPE; pfam00823 1205676009684 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676009685 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1205676009686 MULE transposase domain; Region: MULE; pfam10551 1205676009687 PE family; Region: PE; pfam00934 1205676009688 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009689 PPE family; Region: PPE; pfam00823 1205676009690 Integrase core domain; Region: rve; pfam00665 1205676009691 Integrase core domain; Region: rve_3; pfam13683 1205676009692 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1205676009693 MULE transposase domain; Region: MULE; pfam10551 1205676009694 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1205676009695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676009696 catalytic residue [active] 1205676009697 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1205676009698 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1205676009699 putative substrate binding site [chemical binding]; other site 1205676009700 putative ATP binding site [chemical binding]; other site 1205676009701 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1205676009702 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1205676009703 glutaminase active site [active] 1205676009704 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1205676009705 dimer interface [polypeptide binding]; other site 1205676009706 active site 1205676009707 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1205676009708 dimer interface [polypeptide binding]; other site 1205676009709 active site 1205676009710 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1205676009711 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1205676009712 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1205676009713 active site 1205676009714 substrate binding site [chemical binding]; other site 1205676009715 metal binding site [ion binding]; metal-binding site 1205676009716 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1205676009717 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1205676009718 23S rRNA interface [nucleotide binding]; other site 1205676009719 L3 interface [polypeptide binding]; other site 1205676009720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205676009721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205676009722 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1205676009723 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1205676009724 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205676009725 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205676009726 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205676009727 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205676009728 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1205676009729 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1205676009730 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205676009731 active site 1205676009732 catalytic residues [active] 1205676009733 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1205676009734 Cutinase; Region: Cutinase; pfam01083 1205676009735 Cutinase; Region: Cutinase; pfam01083 1205676009736 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1205676009737 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 1205676009738 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1205676009739 dimerization interface 3.5A [polypeptide binding]; other site 1205676009740 active site 1205676009741 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1205676009742 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1205676009743 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1205676009744 alphaNTD - beta interaction site [polypeptide binding]; other site 1205676009745 alphaNTD homodimer interface [polypeptide binding]; other site 1205676009746 alphaNTD - beta' interaction site [polypeptide binding]; other site 1205676009747 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1205676009748 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1205676009749 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1205676009750 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1205676009751 RNA binding surface [nucleotide binding]; other site 1205676009752 30S ribosomal protein S11; Validated; Region: PRK05309 1205676009753 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1205676009754 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1205676009755 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1205676009756 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1205676009757 rRNA binding site [nucleotide binding]; other site 1205676009758 predicted 30S ribosome binding site; other site 1205676009759 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1205676009760 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1205676009761 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1205676009762 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1205676009763 NAD binding site [chemical binding]; other site 1205676009764 substrate binding site [chemical binding]; other site 1205676009765 homodimer interface [polypeptide binding]; other site 1205676009766 active site 1205676009767 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1205676009768 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205676009769 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205676009770 active site 1205676009771 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205676009772 extended (e) SDRs; Region: SDR_e; cd08946 1205676009773 NAD(P) binding site [chemical binding]; other site 1205676009774 active site 1205676009775 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1205676009776 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1205676009777 active site 1205676009778 catalytic residues [active] 1205676009779 metal binding site [ion binding]; metal-binding site 1205676009780 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1205676009781 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205676009782 PYR/PP interface [polypeptide binding]; other site 1205676009783 dimer interface [polypeptide binding]; other site 1205676009784 TPP binding site [chemical binding]; other site 1205676009785 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1205676009786 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1205676009787 TPP-binding site [chemical binding]; other site 1205676009788 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1205676009789 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1205676009790 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676009791 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205676009792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676009793 metabolite-proton symporter; Region: 2A0106; TIGR00883 1205676009794 putative substrate translocation pore; other site 1205676009795 PE family; Region: PE; pfam00934 1205676009796 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009797 PPE family; Region: PPE; pfam00823 1205676009798 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676009799 patatin-related protein; Region: TIGR03607 1205676009800 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205676009801 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205676009802 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1205676009803 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1205676009804 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1205676009805 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1205676009806 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1205676009807 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1205676009808 short chain dehydrogenase; Provisional; Region: PRK05875 1205676009809 classical (c) SDRs; Region: SDR_c; cd05233 1205676009810 NAD(P) binding site [chemical binding]; other site 1205676009811 active site 1205676009812 Predicted membrane protein [Function unknown]; Region: COG2259 1205676009813 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1205676009814 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1205676009815 Predicted transcriptional regulators [Transcription]; Region: COG1695 1205676009816 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1205676009817 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1205676009818 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1205676009819 active site 1205676009820 homotetramer interface [polypeptide binding]; other site 1205676009821 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676009822 mce related protein; Region: MCE; pfam02470 1205676009823 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676009824 mce related protein; Region: MCE; pfam02470 1205676009825 mce related protein; Region: MCE; pfam02470 1205676009826 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676009827 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205676009828 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676009829 mce related protein; Region: MCE; pfam02470 1205676009830 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676009831 mce related protein; Region: MCE; pfam02470 1205676009832 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1205676009833 mce related protein; Region: MCE; pfam02470 1205676009834 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1205676009835 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205676009836 Permease; Region: Permease; pfam02405 1205676009837 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1205676009838 Permease; Region: Permease; pfam02405 1205676009839 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1205676009840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676009841 NAD(P) binding site [chemical binding]; other site 1205676009842 active site 1205676009843 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1205676009844 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1205676009845 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676009846 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1205676009847 FAD binding site [chemical binding]; other site 1205676009848 substrate binding site [chemical binding]; other site 1205676009849 catalytic base [active] 1205676009850 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676009851 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676009852 active site 1205676009853 acyl-CoA synthetase; Validated; Region: PRK07867 1205676009854 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1205676009855 acyl-activating enzyme (AAE) consensus motif; other site 1205676009856 putative AMP binding site [chemical binding]; other site 1205676009857 putative active site [active] 1205676009858 putative CoA binding site [chemical binding]; other site 1205676009859 PE family; Region: PE; pfam00934 1205676009860 hypothetical protein; Validated; Region: PRK07586 1205676009861 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1205676009862 PYR/PP interface [polypeptide binding]; other site 1205676009863 dimer interface [polypeptide binding]; other site 1205676009864 TPP binding site [chemical binding]; other site 1205676009865 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1205676009866 TPP-binding site [chemical binding]; other site 1205676009867 dimer interface [polypeptide binding]; other site 1205676009868 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1205676009869 PE family; Region: PE; pfam00934 1205676009870 acyl-CoA synthetase; Validated; Region: PRK07798 1205676009871 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676009872 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1205676009873 acyl-activating enzyme (AAE) consensus motif; other site 1205676009874 acyl-activating enzyme (AAE) consensus motif; other site 1205676009875 putative AMP binding site [chemical binding]; other site 1205676009876 putative active site [active] 1205676009877 putative CoA binding site [chemical binding]; other site 1205676009878 enoyl-CoA hydratase; Provisional; Region: PRK07799 1205676009879 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676009880 substrate binding site [chemical binding]; other site 1205676009881 oxyanion hole (OAH) forming residues; other site 1205676009882 trimer interface [polypeptide binding]; other site 1205676009883 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1205676009884 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676009885 Cytochrome P450; Region: p450; cl12078 1205676009886 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1205676009887 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1205676009888 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1205676009889 DUF35 OB-fold domain; Region: DUF35; pfam01796 1205676009890 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1205676009891 DUF35 OB-fold domain; Region: DUF35; pfam01796 1205676009892 lipid-transfer protein; Provisional; Region: PRK07937 1205676009893 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205676009894 active site 1205676009895 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1205676009896 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205676009897 active site 1205676009898 NHL repeat; Region: NHL; pfam01436 1205676009899 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1205676009900 NHL repeat; Region: NHL; pfam01436 1205676009901 NHL repeat; Region: NHL; pfam01436 1205676009902 NHL repeat; Region: NHL; pfam01436 1205676009903 NHL repeat; Region: NHL; pfam01436 1205676009904 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1205676009905 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1205676009906 trimer interface [polypeptide binding]; other site 1205676009907 putative metal binding site [ion binding]; other site 1205676009908 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1205676009909 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1205676009910 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1205676009911 short chain dehydrogenase; Provisional; Region: PRK07890 1205676009912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676009913 NAD(P) binding site [chemical binding]; other site 1205676009914 active site 1205676009915 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009916 PPE family; Region: PPE; pfam00823 1205676009917 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1205676009918 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009919 PPE family; Region: PPE; pfam00823 1205676009920 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009921 Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469 1205676009922 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1205676009923 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1205676009924 active site 1205676009925 catalytic residues [active] 1205676009926 metal binding site [ion binding]; metal-binding site 1205676009927 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1205676009928 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1205676009929 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1205676009930 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1205676009931 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1205676009932 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1205676009933 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1205676009934 enoyl-CoA hydratase; Region: PLN02864 1205676009935 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1205676009936 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1205676009937 dimer interaction site [polypeptide binding]; other site 1205676009938 substrate-binding tunnel; other site 1205676009939 active site 1205676009940 catalytic site [active] 1205676009941 substrate binding site [chemical binding]; other site 1205676009942 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676009943 PPE family; Region: PPE; pfam00823 1205676009944 PE-PPE domain; Region: PE-PPE; pfam08237 1205676009945 lipid-transfer protein; Provisional; Region: PRK07855 1205676009946 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1205676009947 active site 1205676009948 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1205676009949 putative active site [active] 1205676009950 putative catalytic site [active] 1205676009951 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1205676009952 active site 1205676009953 catalytic site [active] 1205676009954 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1205676009955 DUF35 OB-fold domain; Region: DUF35; pfam01796 1205676009956 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676009957 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676009958 active site 1205676009959 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676009960 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205676009961 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676009962 active site 1205676009963 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676009964 Cytochrome P450; Region: p450; cl12078 1205676009965 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1205676009966 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205676009967 dimer interface [polypeptide binding]; other site 1205676009968 active site 1205676009969 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1205676009970 short chain dehydrogenase; Provisional; Region: PRK07791 1205676009971 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1205676009972 homodimer interface [polypeptide binding]; other site 1205676009973 NAD binding site [chemical binding]; other site 1205676009974 active site 1205676009975 short chain dehydrogenase; Provisional; Region: PRK07856 1205676009976 classical (c) SDRs; Region: SDR_c; cd05233 1205676009977 NAD(P) binding site [chemical binding]; other site 1205676009978 active site 1205676009979 enoyl-CoA hydratase; Provisional; Region: PRK06495 1205676009980 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676009981 substrate binding site [chemical binding]; other site 1205676009982 oxyanion hole (OAH) forming residues; other site 1205676009983 trimer interface [polypeptide binding]; other site 1205676009984 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1205676009985 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1205676009986 Nitronate monooxygenase; Region: NMO; pfam03060 1205676009987 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1205676009988 FMN binding site [chemical binding]; other site 1205676009989 substrate binding site [chemical binding]; other site 1205676009990 putative catalytic residue [active] 1205676009991 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1205676009992 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 1205676009993 putative di-iron ligands [ion binding]; other site 1205676009994 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1205676009995 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1205676009996 FAD binding pocket [chemical binding]; other site 1205676009997 FAD binding motif [chemical binding]; other site 1205676009998 phosphate binding motif [ion binding]; other site 1205676009999 beta-alpha-beta structure motif; other site 1205676010000 NAD(p) ribose binding residues [chemical binding]; other site 1205676010001 NAD binding pocket [chemical binding]; other site 1205676010002 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1205676010003 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205676010004 catalytic loop [active] 1205676010005 iron binding site [ion binding]; other site 1205676010006 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1205676010007 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1205676010008 putative active site [active] 1205676010009 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1205676010010 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1205676010011 dimer interface [polypeptide binding]; other site 1205676010012 active site 1205676010013 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676010014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676010015 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676010016 PPE family; Region: PPE; pfam00823 1205676010017 short chain dehydrogenase; Provisional; Region: PRK07831 1205676010018 classical (c) SDRs; Region: SDR_c; cd05233 1205676010019 NAD(P) binding site [chemical binding]; other site 1205676010020 active site 1205676010021 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676010022 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676010023 active site 1205676010024 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1205676010025 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1205676010026 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1205676010027 acyl-activating enzyme (AAE) consensus motif; other site 1205676010028 acyl-activating enzyme (AAE) consensus motif; other site 1205676010029 putative AMP binding site [chemical binding]; other site 1205676010030 putative active site [active] 1205676010031 putative CoA binding site [chemical binding]; other site 1205676010032 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676010033 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676010034 active site 1205676010035 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676010036 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205676010037 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676010038 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676010039 active site 1205676010040 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676010041 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1205676010042 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676010043 active site 1205676010044 aspartate aminotransferase; Provisional; Region: PRK05764 1205676010045 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205676010046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676010047 homodimer interface [polypeptide binding]; other site 1205676010048 catalytic residue [active] 1205676010049 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1205676010050 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205676010051 putative active site [active] 1205676010052 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1205676010053 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1205676010054 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1205676010055 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1205676010056 active site 1205676010057 Fe binding site [ion binding]; other site 1205676010058 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1205676010059 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1205676010060 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676010061 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1205676010062 Flavin binding site [chemical binding]; other site 1205676010063 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1205676010064 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1205676010065 FAD binding pocket [chemical binding]; other site 1205676010066 FAD binding motif [chemical binding]; other site 1205676010067 phosphate binding motif [ion binding]; other site 1205676010068 beta-alpha-beta structure motif; other site 1205676010069 NAD(p) ribose binding residues [chemical binding]; other site 1205676010070 NAD binding pocket [chemical binding]; other site 1205676010071 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1205676010072 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1205676010073 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1205676010074 catalytic loop [active] 1205676010075 iron binding site [ion binding]; other site 1205676010076 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676010077 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676010078 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1205676010079 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676010080 active site 1205676010081 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676010082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676010083 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1205676010084 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1205676010085 DNA binding site [nucleotide binding] 1205676010086 domain linker motif; other site 1205676010087 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1205676010088 putative dimerization interface [polypeptide binding]; other site 1205676010089 putative ligand binding site [chemical binding]; other site 1205676010090 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205676010091 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1205676010092 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1205676010093 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1205676010094 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1205676010095 transmembrane helices; other site 1205676010096 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1205676010097 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1205676010098 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1205676010099 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1205676010100 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1205676010101 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1205676010102 active site 1205676010103 HIGH motif; other site 1205676010104 nucleotide binding site [chemical binding]; other site 1205676010105 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1205676010106 KMSKS motif; other site 1205676010107 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1205676010108 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1205676010109 homotrimer interaction site [polypeptide binding]; other site 1205676010110 zinc binding site [ion binding]; other site 1205676010111 CDP-binding sites; other site 1205676010112 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1205676010113 substrate binding site; other site 1205676010114 dimer interface; other site 1205676010115 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1205676010116 DNA repair protein RadA; Provisional; Region: PRK11823 1205676010117 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1205676010118 Walker A motif/ATP binding site; other site 1205676010119 ATP binding site [chemical binding]; other site 1205676010120 Walker B motif; other site 1205676010121 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1205676010122 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1205676010123 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1205676010124 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1205676010125 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1205676010126 active site clefts [active] 1205676010127 zinc binding site [ion binding]; other site 1205676010128 dimer interface [polypeptide binding]; other site 1205676010129 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1205676010130 endonuclease III; Region: ENDO3c; smart00478 1205676010131 minor groove reading motif; other site 1205676010132 helix-hairpin-helix signature motif; other site 1205676010133 substrate binding pocket [chemical binding]; other site 1205676010134 active site 1205676010135 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1205676010136 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676010137 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1205676010138 catalytic site [active] 1205676010139 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1205676010140 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1205676010141 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1205676010142 Ami_2 domain; Region: Ami_2; smart00644 1205676010143 amidase catalytic site [active] 1205676010144 Zn binding residues [ion binding]; other site 1205676010145 substrate binding site [chemical binding]; other site 1205676010146 PE family; Region: PE; pfam00934 1205676010147 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1205676010148 Clp amino terminal domain; Region: Clp_N; pfam02861 1205676010149 Clp amino terminal domain; Region: Clp_N; pfam02861 1205676010150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676010151 Walker A motif; other site 1205676010152 ATP binding site [chemical binding]; other site 1205676010153 Walker B motif; other site 1205676010154 arginine finger; other site 1205676010155 UvrB/uvrC motif; Region: UVR; pfam02151 1205676010156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676010157 Walker A motif; other site 1205676010158 ATP binding site [chemical binding]; other site 1205676010159 Walker B motif; other site 1205676010160 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1205676010161 Lsr2; Region: Lsr2; pfam11774 1205676010162 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1205676010163 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1205676010164 dimer interface [polypeptide binding]; other site 1205676010165 putative anticodon binding site; other site 1205676010166 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1205676010167 motif 1; other site 1205676010168 dimer interface [polypeptide binding]; other site 1205676010169 active site 1205676010170 motif 2; other site 1205676010171 motif 3; other site 1205676010172 pantothenate kinase; Reviewed; Region: PRK13318 1205676010173 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1205676010174 tetramerization interface [polypeptide binding]; other site 1205676010175 active site 1205676010176 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1205676010177 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1205676010178 active site 1205676010179 ATP-binding site [chemical binding]; other site 1205676010180 pantoate-binding site; other site 1205676010181 HXXH motif; other site 1205676010182 Rossmann-like domain; Region: Rossmann-like; pfam10727 1205676010183 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1205676010184 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1205676010185 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1205676010186 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1205676010187 catalytic center binding site [active] 1205676010188 ATP binding site [chemical binding]; other site 1205676010189 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1205676010190 homooctamer interface [polypeptide binding]; other site 1205676010191 active site 1205676010192 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1205676010193 dihydropteroate synthase; Region: DHPS; TIGR01496 1205676010194 substrate binding pocket [chemical binding]; other site 1205676010195 dimer interface [polypeptide binding]; other site 1205676010196 inhibitor binding site; inhibition site 1205676010197 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1205676010198 homodecamer interface [polypeptide binding]; other site 1205676010199 GTP cyclohydrolase I; Provisional; Region: PLN03044 1205676010200 active site 1205676010201 putative catalytic site residues [active] 1205676010202 zinc binding site [ion binding]; other site 1205676010203 GTP-CH-I/GFRP interaction surface; other site 1205676010204 FtsH Extracellular; Region: FtsH_ext; pfam06480 1205676010205 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1205676010206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676010207 Walker A motif; other site 1205676010208 ATP binding site [chemical binding]; other site 1205676010209 Walker B motif; other site 1205676010210 arginine finger; other site 1205676010211 Peptidase family M41; Region: Peptidase_M41; pfam01434 1205676010212 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1205676010213 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676010214 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1205676010215 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1205676010216 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1205676010217 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205676010218 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1205676010219 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676010220 PPE family; Region: PPE; pfam00823 1205676010221 PE family; Region: PE; pfam00934 1205676010222 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1205676010223 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1205676010224 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1205676010225 active site 1205676010226 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1205676010227 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1205676010228 Ligand Binding Site [chemical binding]; other site 1205676010229 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1205676010230 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1205676010231 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1205676010232 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1205676010233 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1205676010234 dimer interface [polypeptide binding]; other site 1205676010235 substrate binding site [chemical binding]; other site 1205676010236 metal binding sites [ion binding]; metal-binding site 1205676010237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899 1205676010238 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1205676010239 Ligand binding site; other site 1205676010240 Putative Catalytic site; other site 1205676010241 DXD motif; other site 1205676010242 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 1205676010243 Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285 1205676010244 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205676010245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676010246 NAD(P) binding site [chemical binding]; other site 1205676010247 active site 1205676010248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1205676010249 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1205676010250 Integrase core domain; Region: rve; pfam00665 1205676010251 Integrase core domain; Region: rve_3; cl15866 1205676010252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1205676010253 transposase; Provisional; Region: PRK06526 1205676010254 IstB-like ATP binding protein; Region: IstB_IS21; pfam01695 1205676010255 Walker B motif; other site 1205676010256 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1205676010257 Fic/DOC family; Region: Fic; cl00960 1205676010258 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1205676010259 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1205676010260 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1205676010261 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1205676010262 dimerization interface [polypeptide binding]; other site 1205676010263 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1205676010264 cyclase homology domain; Region: CHD; cd07302 1205676010265 nucleotidyl binding site; other site 1205676010266 metal binding site [ion binding]; metal-binding site 1205676010267 dimer interface [polypeptide binding]; other site 1205676010268 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1205676010269 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1205676010270 active site 1205676010271 interdomain interaction site; other site 1205676010272 putative metal-binding site [ion binding]; other site 1205676010273 nucleotide binding site [chemical binding]; other site 1205676010274 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1205676010275 domain I; other site 1205676010276 phosphate binding site [ion binding]; other site 1205676010277 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1205676010278 domain II; other site 1205676010279 domain III; other site 1205676010280 nucleotide binding site [chemical binding]; other site 1205676010281 DNA binding groove [nucleotide binding] 1205676010282 catalytic site [active] 1205676010283 domain IV; other site 1205676010284 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1205676010285 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1205676010286 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1205676010287 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1205676010288 DNA-binding site [nucleotide binding]; DNA binding site 1205676010289 RNA-binding motif; other site 1205676010290 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1205676010291 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1205676010292 ATP binding site [chemical binding]; other site 1205676010293 putative Mg++ binding site [ion binding]; other site 1205676010294 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1205676010295 nucleotide binding region [chemical binding]; other site 1205676010296 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1205676010297 PE family; Region: PE; pfam00934 1205676010298 PE family; Region: PE; pfam00934 1205676010299 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1205676010300 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1205676010301 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1205676010302 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1205676010303 Walker A motif; other site 1205676010304 hexamer interface [polypeptide binding]; other site 1205676010305 ATP binding site [chemical binding]; other site 1205676010306 Walker B motif; other site 1205676010307 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1205676010308 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1205676010309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205676010310 motif II; other site 1205676010311 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1205676010312 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205676010313 Walker A/P-loop; other site 1205676010314 ATP binding site [chemical binding]; other site 1205676010315 Q-loop/lid; other site 1205676010316 ABC transporter signature motif; other site 1205676010317 Walker B; other site 1205676010318 D-loop; other site 1205676010319 H-loop/switch region; other site 1205676010320 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1205676010321 Walker A/P-loop; other site 1205676010322 ATP binding site [chemical binding]; other site 1205676010323 Q-loop/lid; other site 1205676010324 ABC transporter signature motif; other site 1205676010325 Walker B; other site 1205676010326 D-loop; other site 1205676010327 H-loop/switch region; other site 1205676010328 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1205676010329 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1205676010330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676010331 ABC-ATPase subunit interface; other site 1205676010332 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1205676010333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676010334 dimer interface [polypeptide binding]; other site 1205676010335 conserved gate region; other site 1205676010336 ABC-ATPase subunit interface; other site 1205676010337 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1205676010338 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1205676010339 acetyl-CoA synthetase; Provisional; Region: PRK00174 1205676010340 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1205676010341 active site 1205676010342 CoA binding site [chemical binding]; other site 1205676010343 acyl-activating enzyme (AAE) consensus motif; other site 1205676010344 AMP binding site [chemical binding]; other site 1205676010345 acetate binding site [chemical binding]; other site 1205676010346 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1205676010347 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1205676010348 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1205676010349 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1205676010350 putative active site [active] 1205676010351 putative CoA binding site [chemical binding]; other site 1205676010352 nudix motif; other site 1205676010353 metal binding site [ion binding]; metal-binding site 1205676010354 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1205676010355 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205676010356 catalytic residues [active] 1205676010357 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1205676010358 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1205676010359 minor groove reading motif; other site 1205676010360 helix-hairpin-helix signature motif; other site 1205676010361 substrate binding pocket [chemical binding]; other site 1205676010362 active site 1205676010363 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1205676010364 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205676010365 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205676010366 ligand binding site [chemical binding]; other site 1205676010367 flexible hinge region; other site 1205676010368 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1205676010369 putative switch regulator; other site 1205676010370 non-specific DNA interactions [nucleotide binding]; other site 1205676010371 DNA binding site [nucleotide binding] 1205676010372 sequence specific DNA binding site [nucleotide binding]; other site 1205676010373 putative cAMP binding site [chemical binding]; other site 1205676010374 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205676010375 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1205676010376 homotrimer interaction site [polypeptide binding]; other site 1205676010377 putative active site [active] 1205676010378 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1205676010379 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1205676010380 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1205676010381 P loop; other site 1205676010382 Nucleotide binding site [chemical binding]; other site 1205676010383 DTAP/Switch II; other site 1205676010384 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1205676010385 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1205676010386 DTAP/Switch II; other site 1205676010387 Switch I; other site 1205676010388 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1205676010389 Transcription factor WhiB; Region: Whib; pfam02467 1205676010390 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1205676010391 Transglycosylase; Region: Transgly; pfam00912 1205676010392 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1205676010393 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1205676010394 phosphodiesterase YaeI; Provisional; Region: PRK11340 1205676010395 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1205676010396 putative active site [active] 1205676010397 putative metal binding site [ion binding]; other site 1205676010398 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1205676010399 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1205676010400 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205676010401 catalytic residue [active] 1205676010402 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1205676010403 Cytochrome P450; Region: p450; cl12078 1205676010404 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1205676010405 anti sigma factor interaction site; other site 1205676010406 regulatory phosphorylation site [posttranslational modification]; other site 1205676010407 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1205676010408 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1205676010409 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1205676010410 MoxR-like ATPases [General function prediction only]; Region: COG0714 1205676010411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676010412 Walker A motif; other site 1205676010413 ATP binding site [chemical binding]; other site 1205676010414 Walker B motif; other site 1205676010415 arginine finger; other site 1205676010416 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1205676010417 Protein of unknown function DUF58; Region: DUF58; pfam01882 1205676010418 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1205676010419 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1205676010420 glycerol kinase; Provisional; Region: glpK; PRK00047 1205676010421 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1205676010422 nucleotide binding site [chemical binding]; other site 1205676010423 Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028 1205676010424 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1205676010425 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1205676010426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676010427 S-adenosylmethionine binding site [chemical binding]; other site 1205676010428 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205676010429 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205676010430 catalytic residue [active] 1205676010431 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1205676010432 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1205676010433 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1205676010434 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1205676010435 putative active site [active] 1205676010436 putative dimer interface [polypeptide binding]; other site 1205676010437 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1205676010438 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1205676010439 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1205676010440 PknH-like extracellular domain; Region: PknH_C; pfam14032 1205676010441 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1205676010442 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1205676010443 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1205676010444 aspartate kinase; Reviewed; Region: PRK06635 1205676010445 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1205676010446 putative nucleotide binding site [chemical binding]; other site 1205676010447 putative catalytic residues [active] 1205676010448 putative Mg ion binding site [ion binding]; other site 1205676010449 putative aspartate binding site [chemical binding]; other site 1205676010450 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1205676010451 putative allosteric regulatory site; other site 1205676010452 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1205676010453 putative allosteric regulatory residue; other site 1205676010454 2-isopropylmalate synthase; Validated; Region: PRK03739 1205676010455 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1205676010456 active site 1205676010457 catalytic residues [active] 1205676010458 metal binding site [ion binding]; metal-binding site 1205676010459 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1205676010460 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1205676010461 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1205676010462 active site 1205676010463 catalytic site [active] 1205676010464 substrate binding site [chemical binding]; other site 1205676010465 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1205676010466 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1205676010467 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1205676010468 catalytic triad [active] 1205676010469 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1205676010470 putative active site [active] 1205676010471 recombination protein RecR; Reviewed; Region: recR; PRK00076 1205676010472 RecR protein; Region: RecR; pfam02132 1205676010473 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1205676010474 putative active site [active] 1205676010475 putative metal-binding site [ion binding]; other site 1205676010476 tetramer interface [polypeptide binding]; other site 1205676010477 hypothetical protein; Validated; Region: PRK00153 1205676010478 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1205676010479 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1205676010480 active site 1205676010481 metal binding site [ion binding]; metal-binding site 1205676010482 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1205676010483 hydrophobic ligand binding site; other site 1205676010484 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205676010485 FAD binding domain; Region: FAD_binding_4; pfam01565 1205676010486 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1205676010487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676010488 S-adenosylmethionine binding site [chemical binding]; other site 1205676010489 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952 1205676010490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676010491 Walker A motif; other site 1205676010492 ATP binding site [chemical binding]; other site 1205676010493 Walker B motif; other site 1205676010494 arginine finger; other site 1205676010495 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1205676010496 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1205676010497 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1205676010498 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205676010499 catalytic residue [active] 1205676010500 Cutinase; Region: Cutinase; pfam01083 1205676010501 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1205676010502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676010503 NAD(P) binding site [chemical binding]; other site 1205676010504 active site 1205676010505 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1205676010506 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1205676010507 putative NAD(P) binding site [chemical binding]; other site 1205676010508 catalytic Zn binding site [ion binding]; other site 1205676010509 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1205676010510 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1205676010511 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1205676010512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1205676010513 putative substrate translocation pore; other site 1205676010514 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1205676010515 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1205676010516 ligand binding site [chemical binding]; other site 1205676010517 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1205676010518 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1205676010519 active site 1205676010520 nucleophile elbow; other site 1205676010521 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 1205676010522 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1205676010523 FeS/SAM binding site; other site 1205676010524 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1205676010525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676010526 S-adenosylmethionine binding site [chemical binding]; other site 1205676010527 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1205676010528 nucleotide binding site [chemical binding]; other site 1205676010529 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1205676010530 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1205676010531 active site 1205676010532 DNA binding site [nucleotide binding] 1205676010533 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1205676010534 DNA binding site [nucleotide binding] 1205676010535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 1205676010536 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662 1205676010537 nudix motif; other site 1205676010538 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205676010539 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205676010540 Uncharacterized conserved protein [Function unknown]; Region: COG1839 1205676010541 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 1205676010542 Integrase core domain; Region: rve; pfam00665 1205676010543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1205676010544 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1205676010545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676010546 Walker A motif; other site 1205676010547 ATP binding site [chemical binding]; other site 1205676010548 Walker B motif; other site 1205676010549 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator 1205676010550 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1205676010551 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1205676010552 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1205676010553 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676010554 PPE family; Region: PPE; pfam00823 1205676010555 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1205676010556 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1205676010557 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1205676010558 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205676010559 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1205676010560 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1205676010561 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1205676010562 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1205676010563 dimerization interface [polypeptide binding]; other site 1205676010564 putative DNA binding site [nucleotide binding]; other site 1205676010565 putative Zn2+ binding site [ion binding]; other site 1205676010566 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 1205676010567 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1205676010568 PIN domain; Region: PIN_3; pfam13470 1205676010569 DNA binding domain, excisionase family; Region: excise; TIGR01764 1205676010570 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1205676010571 active site 1205676010572 Int/Topo IB signature motif; other site 1205676010573 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1205676010574 nucleoside/Zn binding site; other site 1205676010575 dimer interface [polypeptide binding]; other site 1205676010576 catalytic motif [active] 1205676010577 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1205676010578 prephenate dehydrogenase; Validated; Region: PRK06545 1205676010579 prephenate dehydrogenase; Validated; Region: PRK08507 1205676010580 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 1205676010581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1205676010582 ABC-ATPase subunit interface; other site 1205676010583 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1205676010584 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1205676010585 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1205676010586 Walker A/P-loop; other site 1205676010587 ATP binding site [chemical binding]; other site 1205676010588 Q-loop/lid; other site 1205676010589 ABC transporter signature motif; other site 1205676010590 Walker B; other site 1205676010591 D-loop; other site 1205676010592 H-loop/switch region; other site 1205676010593 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1205676010594 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1205676010595 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1205676010596 putative active site [active] 1205676010597 putative substrate binding site [chemical binding]; other site 1205676010598 ATP binding site [chemical binding]; other site 1205676010599 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1205676010600 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1205676010601 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1205676010602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1205676010603 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1205676010604 dimerization interface [polypeptide binding]; other site 1205676010605 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1205676010606 dimer interface [polypeptide binding]; other site 1205676010607 phosphorylation site [posttranslational modification] 1205676010608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1205676010609 ATP binding site [chemical binding]; other site 1205676010610 Mg2+ binding site [ion binding]; other site 1205676010611 G-X-G motif; other site 1205676010612 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1205676010613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1205676010614 active site 1205676010615 phosphorylation site [posttranslational modification] 1205676010616 intermolecular recognition site; other site 1205676010617 dimerization interface [polypeptide binding]; other site 1205676010618 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1205676010619 DNA binding site [nucleotide binding] 1205676010620 Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243 1205676010621 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205676010622 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205676010623 SnoaL-like domain; Region: SnoaL_2; pfam12680 1205676010624 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205676010625 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme 1205676010626 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1205676010627 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1205676010628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1205676010629 homodimer interface [polypeptide binding]; other site 1205676010630 catalytic residue [active] 1205676010631 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1205676010632 TIGR03086 family protein; Region: TIGR03086 1205676010633 enoyl-CoA hydratase; Provisional; Region: PRK06142 1205676010634 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1205676010635 substrate binding site [chemical binding]; other site 1205676010636 oxyanion hole (OAH) forming residues; other site 1205676010637 trimer interface [polypeptide binding]; other site 1205676010638 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1205676010639 Beta-lactamase; Region: Beta-lactamase; pfam00144 1205676010640 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1205676010641 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1205676010642 active site 1205676010643 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1205676010644 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1205676010645 NAD(P) binding site [chemical binding]; other site 1205676010646 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1205676010647 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 1205676010648 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1205676010649 catalytic residue [active] 1205676010650 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1205676010651 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1205676010652 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1205676010653 Walker A/P-loop; other site 1205676010654 ATP binding site [chemical binding]; other site 1205676010655 Q-loop/lid; other site 1205676010656 ABC transporter signature motif; other site 1205676010657 Walker B; other site 1205676010658 D-loop; other site 1205676010659 H-loop/switch region; other site 1205676010660 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1205676010661 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205676010662 active site 1205676010663 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1205676010664 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1205676010665 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1205676010666 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1205676010667 NAD binding site [chemical binding]; other site 1205676010668 substrate binding site [chemical binding]; other site 1205676010669 active site 1205676010670 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1205676010671 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205676010672 active site 1205676010673 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1205676010674 Peptidase family M23; Region: Peptidase_M23; pfam01551 1205676010675 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1205676010676 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1205676010677 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1205676010678 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1205676010679 Predicted membrane protein [Function unknown]; Region: COG2246 1205676010680 GtrA-like protein; Region: GtrA; pfam04138 1205676010681 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1205676010682 FAD binding domain; Region: FAD_binding_4; pfam01565 1205676010683 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1205676010684 short chain dehydrogenase; Provisional; Region: PRK07904 1205676010685 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1205676010686 NAD(P) binding site [chemical binding]; other site 1205676010687 active site 1205676010688 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1205676010689 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1205676010690 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1205676010691 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1205676010692 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1205676010693 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1205676010694 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1205676010695 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1205676010696 FAD binding site [chemical binding]; other site 1205676010697 substrate binding site [chemical binding]; other site 1205676010698 catalytic residues [active] 1205676010699 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1205676010700 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1205676010701 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1205676010702 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676010703 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676010704 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1205676010705 active site 1205676010706 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1205676010707 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205676010708 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676010709 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1205676010710 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1205676010711 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205676010712 acyl-activating enzyme (AAE) consensus motif; other site 1205676010713 active site 1205676010714 Cutinase; Region: Cutinase; pfam01083 1205676010715 Predicted esterase [General function prediction only]; Region: COG0627 1205676010716 Putative esterase; Region: Esterase; pfam00756 1205676010717 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1205676010718 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1205676010719 active site 1205676010720 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1205676010721 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1205676010722 active site 1205676010723 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1205676010724 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205676010725 UDP-galactopyranose mutase; Region: GLF; pfam03275 1205676010726 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1205676010727 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1205676010728 amidase catalytic site [active] 1205676010729 Zn binding residues [ion binding]; other site 1205676010730 substrate binding site [chemical binding]; other site 1205676010731 LGFP repeat; Region: LGFP; pfam08310 1205676010732 PE family; Region: PE; pfam00934 1205676010733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1205676010734 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1205676010735 active site 1205676010736 motif I; other site 1205676010737 motif II; other site 1205676010738 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1205676010739 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205676010740 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205676010741 putative acyl-acceptor binding pocket; other site 1205676010742 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205676010743 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205676010744 putative acyl-acceptor binding pocket; other site 1205676010745 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1205676010746 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1205676010747 putative acyl-acceptor binding pocket; other site 1205676010748 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1205676010749 Phosphotransferase enzyme family; Region: APH; pfam01636 1205676010750 active site 1205676010751 ATP binding site [chemical binding]; other site 1205676010752 antibiotic binding site [chemical binding]; other site 1205676010753 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1205676010754 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1205676010755 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1205676010756 iron-sulfur cluster [ion binding]; other site 1205676010757 [2Fe-2S] cluster binding site [ion binding]; other site 1205676010758 Condensation domain; Region: Condensation; pfam00668 1205676010759 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1205676010760 PE-PPE domain; Region: PE-PPE; pfam08237 1205676010761 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1205676010762 Condensation domain; Region: Condensation; pfam00668 1205676010763 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1205676010764 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1205676010765 active site 1205676010766 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1205676010767 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1205676010768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1205676010769 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1205676010770 Enoylreductase; Region: PKS_ER; smart00829 1205676010771 NAD(P) binding site [chemical binding]; other site 1205676010772 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1205676010773 KR domain; Region: KR; pfam08659 1205676010774 putative NADP binding site [chemical binding]; other site 1205676010775 active site 1205676010776 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1205676010777 acyl-CoA synthetase; Validated; Region: PRK05850 1205676010778 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1205676010779 acyl-activating enzyme (AAE) consensus motif; other site 1205676010780 active site 1205676010781 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1205676010782 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1205676010783 Probable transposase; Region: OrfB_IS605; pfam01385 1205676010784 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 1205676010785 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1205676010786 catalytic residues [active] 1205676010787 catalytic nucleophile [active] 1205676010788 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1205676010789 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205676010790 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1205676010791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676010792 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1205676010793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1205676010794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1205676010795 Cupin domain; Region: Cupin_2; cl17218 1205676010796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1205676010797 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1205676010798 seryl-tRNA synthetase; Provisional; Region: PRK05431 1205676010799 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1205676010800 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1205676010801 dimer interface [polypeptide binding]; other site 1205676010802 active site 1205676010803 motif 1; other site 1205676010804 motif 2; other site 1205676010805 motif 3; other site 1205676010806 Septum formation; Region: Septum_form; pfam13845 1205676010807 Septum formation; Region: Septum_form; pfam13845 1205676010808 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1205676010809 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1205676010810 catalytic core [active] 1205676010811 prephenate dehydratase; Provisional; Region: PRK11898 1205676010812 Prephenate dehydratase; Region: PDT; pfam00800 1205676010813 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1205676010814 putative L-Phe binding site [chemical binding]; other site 1205676010815 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pr : putative regulator 1205676010816 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pr : putative regulator 1205676010817 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1205676010818 Ferritin-like domain; Region: Ferritin; pfam00210 1205676010819 ferroxidase diiron center [ion binding]; other site 1205676010820 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1205676010821 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1205676010822 putative active site [active] 1205676010823 catalytic site [active] 1205676010824 putative metal binding site [ion binding]; other site 1205676010825 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1205676010826 Integrase core domain; Region: rve; pfam00665 1205676010827 Integrase core domain; Region: rve_3; pfam13683 1205676010828 Transposase; Region: HTH_Tnp_1; pfam01527 1205676010829 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1205676010830 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1205676010831 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1205676010832 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1205676010833 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1205676010834 Predicted membrane protein [Function unknown]; Region: COG2119 1205676010835 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1205676010836 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1205676010837 Fimbrial protein; Region: Fimbrial; cl01416 1205676010838 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1205676010839 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1205676010840 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1205676010841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1205676010842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1205676010843 hypothetical protein; Provisional; Region: PRK07945 1205676010844 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1205676010845 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1205676010846 active site 1205676010847 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1205676010848 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1205676010849 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1205676010850 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1205676010851 active site 1205676010852 dimer interface [polypeptide binding]; other site 1205676010853 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1205676010854 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1205676010855 active site 1205676010856 FMN binding site [chemical binding]; other site 1205676010857 substrate binding site [chemical binding]; other site 1205676010858 3Fe-4S cluster binding site [ion binding]; other site 1205676010859 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1205676010860 domain interface; other site 1205676010861 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1205676010862 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1205676010863 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1205676010864 EspG family; Region: ESX-1_EspG; pfam14011 1205676010865 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1205676010866 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676010867 Walker A motif; other site 1205676010868 ATP binding site [chemical binding]; other site 1205676010869 Walker B motif; other site 1205676010870 arginine finger; other site 1205676010871 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1205676010872 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1205676010873 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205676010874 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205676010875 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205676010876 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205676010877 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1205676010878 PPE family; Region: PPE; pfam00823 1205676010879 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1205676010880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205676010881 Evidence 4 : Homologs of previously reported genes of unknown function 1205676010882 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11597336, 12692540, 15525680 1205676010883 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1205676010884 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1205676010885 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1205676010886 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205676010887 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1205676010888 active site 1205676010889 catalytic residues [active] 1205676010890 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1205676010891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1205676010892 Walker A motif; other site 1205676010893 ATP binding site [chemical binding]; other site 1205676010894 Walker B motif; other site 1205676010895 arginine finger; other site 1205676010896 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1205676010897 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205676010898 catalytic residues [active] 1205676010899 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1205676010900 active site 1205676010901 catalytic residues [active] 1205676010902 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1205676010903 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1205676010904 EspG family; Region: ESX-1_EspG; pfam14011 1205676010905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205676010906 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1205676010907 PPE family; Region: PPE; pfam00823 1205676010908 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1205676010909 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205676010910 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1205676010911 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205676010912 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1205676010913 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1205676010914 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1205676010915 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1205676010916 catalytic residue [active] 1205676010917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1205676010918 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1205676010919 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1205676010920 active site 1205676010921 NTP binding site [chemical binding]; other site 1205676010922 metal binding triad [ion binding]; metal-binding site 1205676010923 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1205676010924 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1205676010925 Zn2+ binding site [ion binding]; other site 1205676010926 Mg2+ binding site [ion binding]; other site 1205676010927 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1205676010928 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1205676010929 active site 1205676010930 Ap6A binding site [chemical binding]; other site 1205676010931 nudix motif; other site 1205676010932 metal binding site [ion binding]; metal-binding site 1205676010933 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1205676010934 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1205676010935 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1205676010936 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1205676010937 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1205676010938 DNA binding residues [nucleotide binding] 1205676010939 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1205676010940 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1205676010941 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1205676010942 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1205676010943 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1205676010944 catalytic residues [active] 1205676010945 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1205676010946 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1205676010947 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1205676010948 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1205676010949 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1205676010950 active site 1205676010951 metal binding site [ion binding]; metal-binding site 1205676010952 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1205676010953 ParB-like nuclease domain; Region: ParB; smart00470 1205676010954 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1205676010955 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205676010956 P-loop; other site 1205676010957 Magnesium ion binding site [ion binding]; other site 1205676010958 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1205676010959 Magnesium ion binding site [ion binding]; other site 1205676010960 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1205676010961 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1205676010962 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1205676010963 G-X-X-G motif; other site 1205676010964 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1205676010965 RxxxH motif; other site 1205676010966 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1205676010967 Uncharacterized conserved protein [Function unknown]; Region: COG0759 1205676010968 Ribonuclease P; Region: Ribonuclease_P; cl00457 1205676010969 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399