-- dump date   	20140619_151813
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1205675000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1205675000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675000003	Walker A motif; other site
1205675000004	ATP binding site [chemical binding]; other site
1205675000005	Walker B motif; other site
1205675000006	arginine finger; other site
1205675000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1205675000008	DnaA box-binding interface [nucleotide binding]; other site
1205675000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
1205675000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1205675000011	putative DNA binding surface [nucleotide binding]; other site
1205675000012	dimer interface [polypeptide binding]; other site
1205675000013	beta-clamp/clamp loader binding surface; other site
1205675000014	beta-clamp/translesion DNA polymerase binding surface; other site
1205675000015	recF protein; Region: recf; TIGR00611
1205675000016	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1205675000017	Walker A/P-loop; other site
1205675000018	ATP binding site [chemical binding]; other site
1205675000019	Q-loop/lid; other site
1205675000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1205675000021	ABC transporter signature motif; other site
1205675000022	Walker B; other site
1205675000023	D-loop; other site
1205675000024	H-loop/switch region; other site
1205675000025	hypothetical protein; Provisional; Region: PRK03195
1205675000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1205675000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1205675000028	Mg2+ binding site [ion binding]; other site
1205675000029	G-X-G motif; other site
1205675000030	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1205675000031	anchoring element; other site
1205675000032	dimer interface [polypeptide binding]; other site
1205675000033	ATP binding site [chemical binding]; other site
1205675000034	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1205675000035	active site
1205675000036	putative metal-binding site [ion binding]; other site
1205675000037	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1205675000038	DNA gyrase subunit A; Validated; Region: PRK05560
1205675000039	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1205675000040	CAP-like domain; other site
1205675000041	active site
1205675000042	primary dimer interface [polypeptide binding]; other site
1205675000043	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1205675000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1205675000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1205675000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1205675000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1205675000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1205675000049	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
1205675000050	Protein of unknown function (DUF2562); Region: DUF2562; pfam10814
1205675000051	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1205675000052	active site
1205675000053	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1205675000054	putative septation inhibitor protein; Reviewed; Region: PRK00159
1205675000055	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
1205675000056	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1205675000057	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1205675000058	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1205675000059	glutamine binding [chemical binding]; other site
1205675000060	catalytic triad [active]
1205675000061	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1205675000062	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1205675000063	active site
1205675000064	ATP binding site [chemical binding]; other site
1205675000065	substrate binding site [chemical binding]; other site
1205675000066	activation loop (A-loop); other site
1205675000067	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1205675000068	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1205675000069	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1205675000070	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1205675000071	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1205675000072	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1205675000073	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1205675000074	active site
1205675000075	ATP binding site [chemical binding]; other site
1205675000076	substrate binding site [chemical binding]; other site
1205675000077	activation loop (A-loop); other site
1205675000078	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1205675000079	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1205675000080	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1205675000081	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1205675000082	active site
1205675000083	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1205675000084	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1205675000085	phosphopeptide binding site; other site
1205675000086	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
1205675000087	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1205675000088	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1205675000089	phosphopeptide binding site; other site
1205675000090	Nitronate monooxygenase; Region: NMO; pfam03060
1205675000091	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1205675000092	FMN binding site [chemical binding]; other site
1205675000093	substrate binding site [chemical binding]; other site
1205675000094	putative catalytic residue [active]
1205675000095	Transcription factor WhiB; Region: Whib; pfam02467
1205675000096	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1205675000097	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1205675000098	non-specific DNA binding site [nucleotide binding]; other site
1205675000099	salt bridge; other site
1205675000100	sequence-specific DNA binding site [nucleotide binding]; other site
1205675000101	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1205675000102	NlpC/P60 family; Region: NLPC_P60; pfam00877
1205675000103	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
1205675000104	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
1205675000105	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
1205675000106	Protein of unknown function (DUF2694); Region: DUF2694; pfam10904
1205675000107	Protein of unknown function (DUF2710); Region: DUF2710; pfam10921
1205675000108	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1205675000109	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
1205675000110	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1205675000111	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1205675000112	catalytic residue [active]
1205675000113	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
1205675000114	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1205675000115	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1205675000116	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1205675000117	acyl-activating enzyme (AAE) consensus motif; other site
1205675000118	active site
1205675000119	TIGR03084 family protein; Region: TIGR03084
1205675000120	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1205675000121	Wyosine base formation; Region: Wyosine_form; pfam08608
1205675000122	H+ Antiporter protein; Region: 2A0121; TIGR00900
1205675000123	hypothetical protein; Validated; Region: PRK00228
1205675000124	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
1205675000125	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1205675000126	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1205675000127	active site
1205675000128	HIGH motif; other site
1205675000129	nucleotide binding site [chemical binding]; other site
1205675000130	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1205675000131	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1205675000132	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1205675000133	active site
1205675000134	KMSKS motif; other site
1205675000135	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1205675000136	tRNA binding surface [nucleotide binding]; other site
1205675000137	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1205675000138	MarR family; Region: MarR; pfam01047
1205675000139	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1205675000140	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1205675000141	DNA-binding site [nucleotide binding]; DNA binding site
1205675000142	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
1205675000143	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1205675000144	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675000145	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
1205675000146	inositol 1-phosphate synthase, Actinobacterial type; Region: mycothiol_INO1; TIGR03450
1205675000147	Predicted transcriptional regulators [Transcription]; Region: COG1695
1205675000148	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1205675000149	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1205675000150	Transglycosylase; Region: Transgly; pfam00912
1205675000151	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1205675000152	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1205675000153	Predicted integral membrane protein [Function unknown]; Region: COG5650
1205675000154	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
1205675000155	conserved cys residue [active]
1205675000156	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1205675000157	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1205675000158	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1205675000159	dimer interface [polypeptide binding]; other site
1205675000160	ssDNA binding site [nucleotide binding]; other site
1205675000161	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1205675000162	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1205675000163	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1205675000164	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1205675000165	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1205675000166	replicative DNA helicase; Validated; Region: PRK07773
1205675000167	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1205675000168	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1205675000169	Walker A motif; other site
1205675000170	ATP binding site [chemical binding]; other site
1205675000171	Walker B motif; other site
1205675000172	DNA binding loops [nucleotide binding]
1205675000173	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1205675000174	protein-splicing catalytic site; other site
1205675000175	thioester formation/cholesterol transfer; other site
1205675000176	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1205675000177	protein-splicing catalytic site; other site
1205675000178	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1205675000179	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
1205675000180	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1205675000181	FAD binding domain; Region: FAD_binding_4; pfam01565
1205675000182	Berberine and berberine like; Region: BBE; pfam08031
1205675000183	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1205675000184	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1205675000185	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
1205675000186	DNA binding residues [nucleotide binding]
1205675000187	dimer interface [polypeptide binding]; other site
1205675000188	metal binding site [ion binding]; metal-binding site
1205675000189	hypothetical protein; Provisional; Region: PRK12438
1205675000190	hypothetical protein; Validated; Region: PRK00068
1205675000191	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
1205675000192	homotetrameric interface [polypeptide binding]; other site
1205675000193	putative active site [active]
1205675000194	metal binding site [ion binding]; metal-binding site
1205675000195	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
1205675000196	Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971
1205675000197	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675000198	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675000199	short chain dehydrogenase; Provisional; Region: PRK06197
1205675000200	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1205675000201	putative NAD(P) binding site [chemical binding]; other site
1205675000202	active site
1205675000203	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1205675000204	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1205675000205	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1205675000206	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1205675000207	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1205675000208	dimer interface [polypeptide binding]; other site
1205675000209	active site
1205675000210	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1205675000211	folate binding site [chemical binding]; other site
1205675000212	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675000213	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675000214	active site
1205675000215	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1205675000216	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1205675000217	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1205675000218	Walker A/P-loop; other site
1205675000219	ATP binding site [chemical binding]; other site
1205675000220	Q-loop/lid; other site
1205675000221	ABC transporter signature motif; other site
1205675000222	Walker B; other site
1205675000223	D-loop; other site
1205675000224	H-loop/switch region; other site
1205675000225	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1205675000226	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1205675000227	ligand binding site [chemical binding]; other site
1205675000228	flexible hinge region; other site
1205675000229	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1205675000230	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1205675000231	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1205675000232	active site
1205675000233	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1205675000234	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1205675000235	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675000236	homodimer interface [polypeptide binding]; other site
1205675000237	catalytic residue [active]
1205675000238	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675000239	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675000240	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675000241	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1205675000242	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1205675000243	dimerization interface [polypeptide binding]; other site
1205675000244	putative DNA binding site [nucleotide binding]; other site
1205675000245	putative Zn2+ binding site [ion binding]; other site
1205675000246	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
1205675000247	hydrogenase 4 subunit B; Validated; Region: PRK06521
1205675000248	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1205675000249	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1205675000250	NADH dehydrogenase; Region: NADHdh; cl00469
1205675000251	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
1205675000252	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1205675000253	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
1205675000254	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
1205675000255	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
1205675000256	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675000257	S-adenosylmethionine binding site [chemical binding]; other site
1205675000258	Predicted membrane protein [Function unknown]; Region: COG3305
1205675000259	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1205675000260	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1205675000261	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1205675000262	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1205675000263	metal-binding site [ion binding]
1205675000264	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1205675000265	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1205675000266	Predicted integral membrane protein [Function unknown]; Region: COG5660
1205675000267	Putative zinc-finger; Region: zf-HC2; pfam13490
1205675000268	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675000269	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675000270	active site
1205675000271	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675000272	PPE family; Region: PPE; pfam00823
1205675000273	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1205675000274	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
1205675000275	FcoT-like thioesterase domain; Region: FcoT; pfam10862
1205675000276	acyl-CoA synthetase; Validated; Region: PRK05857
1205675000277	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675000278	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675000279	acyl-activating enzyme (AAE) consensus motif; other site
1205675000280	acyl-activating enzyme (AAE) consensus motif; other site
1205675000281	AMP binding site [chemical binding]; other site
1205675000282	active site
1205675000283	CoA binding site [chemical binding]; other site
1205675000284	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1205675000285	AMP-binding enzyme; Region: AMP-binding; pfam00501
1205675000286	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675000287	acyl-activating enzyme (AAE) consensus motif; other site
1205675000288	active site
1205675000289	AMP binding site [chemical binding]; other site
1205675000290	CoA binding site [chemical binding]; other site
1205675000291	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1205675000292	Condensation domain; Region: Condensation; pfam00668
1205675000293	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1205675000294	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1205675000295	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1205675000296	acyl-activating enzyme (AAE) consensus motif; other site
1205675000297	AMP binding site [chemical binding]; other site
1205675000298	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1205675000299	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
1205675000300	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1205675000301	putative NAD(P) binding site [chemical binding]; other site
1205675000302	active site
1205675000303	putative substrate binding site [chemical binding]; other site
1205675000304	Predicted membrane protein [Function unknown]; Region: COG3336
1205675000305	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1205675000306	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1205675000307	metal-binding site [ion binding]
1205675000308	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1205675000309	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1205675000310	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1205675000311	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1205675000312	ligand binding site [chemical binding]; other site
1205675000313	flexible hinge region; other site
1205675000314	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1205675000315	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1205675000316	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1205675000317	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1205675000318	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1205675000319	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1205675000320	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1205675000321	motif II; other site
1205675000322	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1205675000323	PE family; Region: PE; pfam00934
1205675000324	Rhomboid family; Region: Rhomboid; pfam01694
1205675000325	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1205675000326	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1205675000327	active site
1205675000328	catalytic triad [active]
1205675000329	oxyanion hole [active]
1205675000330	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1205675000331	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1205675000332	NADP-binding site; other site
1205675000333	homotetramer interface [polypeptide binding]; other site
1205675000334	substrate binding site [chemical binding]; other site
1205675000335	homodimer interface [polypeptide binding]; other site
1205675000336	active site
1205675000337	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1205675000338	dimer interface [polypeptide binding]; other site
1205675000339	active site
1205675000340	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
1205675000341	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1205675000342	active site
1205675000343	motif I; other site
1205675000344	motif II; other site
1205675000345	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
1205675000346	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1205675000347	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1205675000348	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1205675000349	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1205675000350	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1205675000351	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1205675000352	dimerization interface [polypeptide binding]; other site
1205675000353	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
1205675000354	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1205675000355	PYR/PP interface [polypeptide binding]; other site
1205675000356	dimer interface [polypeptide binding]; other site
1205675000357	TPP binding site [chemical binding]; other site
1205675000358	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1205675000359	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
1205675000360	TPP-binding site; other site
1205675000361	dimer interface [polypeptide binding]; other site
1205675000362	acyl-CoA synthetase; Validated; Region: PRK05852
1205675000363	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675000364	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
1205675000365	acyl-activating enzyme (AAE) consensus motif; other site
1205675000366	acyl-activating enzyme (AAE) consensus motif; other site
1205675000367	putative AMP binding site [chemical binding]; other site
1205675000368	putative active site [active]
1205675000369	putative CoA binding site [chemical binding]; other site
1205675000370	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
1205675000371	elongation factor G; Reviewed; Region: PRK12740
1205675000372	G1 box; other site
1205675000373	putative GEF interaction site [polypeptide binding]; other site
1205675000374	GTP/Mg2+ binding site [chemical binding]; other site
1205675000375	Switch I region; other site
1205675000376	G2 box; other site
1205675000377	G3 box; other site
1205675000378	Switch II region; other site
1205675000379	G4 box; other site
1205675000380	G5 box; other site
1205675000381	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1205675000382	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1205675000383	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1205675000384	PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668
1205675000385	PE family; Region: PE; pfam00934
1205675000386	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1205675000387	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1205675000388	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1205675000389	trehalose synthase; Region: treS_nterm; TIGR02456
1205675000390	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
1205675000391	active site
1205675000392	catalytic site [active]
1205675000393	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
1205675000394	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
1205675000395	Predicted membrane protein [Function unknown]; Region: COG3619
1205675000396	Predicted esterase [General function prediction only]; Region: COG0627
1205675000397	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1205675000398	putative active site [active]
1205675000399	putative catalytic site [active]
1205675000400	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675000401	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675000402	active site
1205675000403	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
1205675000404	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1205675000405	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1205675000406	Coenzyme A binding pocket [chemical binding]; other site
1205675000407	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675000408	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1205675000409	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675000410	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675000411	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675000412	Cytochrome P450; Region: p450; cl12078
1205675000413	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1205675000414	SnoaL-like domain; Region: SnoaL_2; pfam12680
1205675000415	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
1205675000416	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675000417	NAD(P) binding site [chemical binding]; other site
1205675000418	active site
1205675000419	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
1205675000420	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1205675000421	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1205675000422	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1205675000423	minor groove reading motif; other site
1205675000424	helix-hairpin-helix signature motif; other site
1205675000425	active site
1205675000426	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1205675000427	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1205675000428	Cl- selectivity filter; other site
1205675000429	Cl- binding residues [ion binding]; other site
1205675000430	pore gating glutamate residue; other site
1205675000431	dimer interface [polypeptide binding]; other site
1205675000432	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675000433	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675000434	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675000435	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1205675000436	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675000437	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1205675000438	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1205675000439	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
1205675000440	NAD(P) binding site [chemical binding]; other site
1205675000441	catalytic residues [active]
1205675000442	short chain dehydrogenase; Provisional; Region: PRK07791
1205675000443	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
1205675000444	NAD binding site [chemical binding]; other site
1205675000445	homodimer interface [polypeptide binding]; other site
1205675000446	active site
1205675000447	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1205675000448	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1205675000449	NAD(P) binding site [chemical binding]; other site
1205675000450	PE family; Region: PE; pfam00934
1205675000451	PE-PPE domain; Region: PE-PPE; pfam08237
1205675000452	PE family; Region: PE; pfam00934
1205675000453	PE-PPE domain; Region: PE-PPE; pfam08237
1205675000454	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
1205675000455	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
1205675000456	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1205675000457	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675000458	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
1205675000459	FAD binding site [chemical binding]; other site
1205675000460	substrate binding site [chemical binding]; other site
1205675000461	catalytic base [active]
1205675000462	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
1205675000463	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10510226; Product type pe : putative enzyme
1205675000464	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15525680; Product type pe : putative enzyme
1205675000465	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
1205675000466	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1205675000467	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675000468	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675000469	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
1205675000470	PE family; Region: PE; pfam00934
1205675000471	PE-PPE domain; Region: PE-PPE; pfam08237
1205675000472	PE family; Region: PE; pfam00934
1205675000473	PE-PPE domain; Region: PE-PPE; pfam08237
1205675000474	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1205675000475	FAD binding domain; Region: FAD_binding_4; pfam01565
1205675000476	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1205675000477	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1205675000478	NAD(P) binding site [chemical binding]; other site
1205675000479	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1205675000480	active site
1205675000481	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1205675000482	putative hydrophobic ligand binding site [chemical binding]; other site
1205675000483	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1205675000484	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1205675000485	DNA-binding site [nucleotide binding]; DNA binding site
1205675000486	FCD domain; Region: FCD; pfam07729
1205675000487	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
1205675000488	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675000489	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1205675000490	acyl-activating enzyme (AAE) consensus motif; other site
1205675000491	acyl-activating enzyme (AAE) consensus motif; other site
1205675000492	putative AMP binding site [chemical binding]; other site
1205675000493	putative active site [active]
1205675000494	putative CoA binding site [chemical binding]; other site
1205675000495	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1205675000496	Permease; Region: Permease; pfam02405
1205675000497	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1205675000498	Permease; Region: Permease; pfam02405
1205675000499	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675000500	mce related protein; Region: MCE; pfam02470
1205675000501	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1205675000502	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675000503	mce related protein; Region: MCE; pfam02470
1205675000504	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1205675000505	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675000506	mce related protein; Region: MCE; pfam02470
1205675000507	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675000508	mce related protein; Region: MCE; pfam02470
1205675000509	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675000510	mce related protein; Region: MCE; pfam02470
1205675000511	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675000512	mce related protein; Region: MCE; pfam02470
1205675000513	RDD family; Region: RDD; pfam06271
1205675000514	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1205675000515	Predicted membrane protein [Function unknown]; Region: COG1511
1205675000516	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1205675000517	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1205675000518	Pirin-related protein [General function prediction only]; Region: COG1741
1205675000519	Pirin; Region: Pirin; pfam02678
1205675000520	RNA polymerase factor sigma-70; Validated; Region: PRK08241
1205675000521	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1205675000522	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1205675000523	DNA binding residues [nucleotide binding]
1205675000524	SnoaL-like domain; Region: SnoaL_2; pfam12680
1205675000525	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1205675000526	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1205675000527	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
1205675000528	putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185
1205675000529	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1205675000530	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1205675000531	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1205675000532	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1205675000533	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1205675000534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675000535	S-adenosylmethionine binding site [chemical binding]; other site
1205675000536	SPW repeat; Region: SPW; pfam03779
1205675000537	SPW repeat; Region: SPW; pfam03779
1205675000538	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1205675000539	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1205675000540	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1205675000541	putative homodimer interface [polypeptide binding]; other site
1205675000542	putative homotetramer interface [polypeptide binding]; other site
1205675000543	putative allosteric switch controlling residues; other site
1205675000544	putative metal binding site [ion binding]; other site
1205675000545	putative homodimer-homodimer interface [polypeptide binding]; other site
1205675000546	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1205675000547	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675000548	putative substrate translocation pore; other site
1205675000549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1205675000550	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1205675000551	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1205675000552	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1205675000553	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1205675000554	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1205675000555	Walker A/P-loop; other site
1205675000556	ATP binding site [chemical binding]; other site
1205675000557	Q-loop/lid; other site
1205675000558	ABC transporter signature motif; other site
1205675000559	Walker B; other site
1205675000560	D-loop; other site
1205675000561	H-loop/switch region; other site
1205675000562	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1205675000563	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1205675000564	Walker A/P-loop; other site
1205675000565	ATP binding site [chemical binding]; other site
1205675000566	Q-loop/lid; other site
1205675000567	ABC transporter signature motif; other site
1205675000568	Walker B; other site
1205675000569	D-loop; other site
1205675000570	H-loop/switch region; other site
1205675000571	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1205675000572	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1205675000573	dimerization interface [polypeptide binding]; other site
1205675000574	DNA binding residues [nucleotide binding]
1205675000575	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675000576	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675000577	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1205675000578	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
1205675000579	putative [Fe4-S4] binding site [ion binding]; other site
1205675000580	putative molybdopterin cofactor binding site [chemical binding]; other site
1205675000581	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1205675000582	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
1205675000583	putative molybdopterin cofactor binding site; other site
1205675000584	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1205675000585	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1205675000586	active site
1205675000587	Zn binding site [ion binding]; other site
1205675000588	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1205675000589	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
1205675000590	Predicted integral membrane protein [Function unknown]; Region: COG0392
1205675000591	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1205675000592	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1205675000593	MMPL family; Region: MMPL; pfam03176
1205675000594	MMPL family; Region: MMPL; pfam03176
1205675000595	LabA_like proteins; Region: LabA_like; cd06167
1205675000596	putative metal binding site [ion binding]; other site
1205675000597	Putative methyltransferase; Region: Methyltransf_4; pfam02390
1205675000598	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
1205675000599	active site
1205675000600	substrate-binding site [chemical binding]; other site
1205675000601	metal-binding site [ion binding]
1205675000602	GTP binding site [chemical binding]; other site
1205675000603	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
1205675000604	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1205675000605	active site
1205675000606	nucleotide binding site [chemical binding]; other site
1205675000607	HIGH motif; other site
1205675000608	KMSKS motif; other site
1205675000609	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
1205675000610	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
1205675000611	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
1205675000612	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1205675000613	FeS/SAM binding site; other site
1205675000614	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
1205675000615	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675000616	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1205675000617	acyl-activating enzyme (AAE) consensus motif; other site
1205675000618	acyl-activating enzyme (AAE) consensus motif; other site
1205675000619	putative AMP binding site [chemical binding]; other site
1205675000620	putative active site [active]
1205675000621	putative CoA binding site [chemical binding]; other site
1205675000622	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675000623	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675000624	active site
1205675000625	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1205675000626	putative active site [active]
1205675000627	putative catalytic site [active]
1205675000628	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1205675000629	active site 2 [active]
1205675000630	active site 1 [active]
1205675000631	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1205675000632	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1205675000633	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1205675000634	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321
1205675000635	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1205675000636	Moco binding site; other site
1205675000637	metal coordination site [ion binding]; other site
1205675000638	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1205675000639	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1205675000640	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1205675000641	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1205675000642	enoyl-CoA hydratase; Provisional; Region: PRK08252
1205675000643	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675000644	substrate binding site [chemical binding]; other site
1205675000645	oxyanion hole (OAH) forming residues; other site
1205675000646	trimer interface [polypeptide binding]; other site
1205675000647	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
1205675000648	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1205675000649	NAD binding site [chemical binding]; other site
1205675000650	catalytic residues [active]
1205675000651	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675000652	S-adenosylmethionine binding site [chemical binding]; other site
1205675000653	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1205675000654	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1205675000655	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
1205675000656	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1205675000657	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1205675000658	putative active site [active]
1205675000659	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1205675000660	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
1205675000661	active site
1205675000662	substrate binding pocket [chemical binding]; other site
1205675000663	homodimer interaction site [polypeptide binding]; other site
1205675000664	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675000665	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1205675000666	active site
1205675000667	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675000668	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675000669	Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911
1205675000670	active site
1205675000671	diiron metal binding site [ion binding]; other site
1205675000672	Evidence 2b : Function of strongly homologous gene; PubMedId : 12657046; Product type e : enzyme
1205675000673	Evidence 2b : Function of strongly homologous gene; PubMedId : 12657046; Product type e : enzyme
1205675000674	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1205675000675	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1205675000676	NAD(P) binding site [chemical binding]; other site
1205675000677	catalytic residues [active]
1205675000678	Lipase maturation factor; Region: LMF1; pfam06762
1205675000679	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
1205675000680	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
1205675000681	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1205675000682	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1205675000683	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675000684	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675000685	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1205675000686	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1205675000687	MaoC like domain; Region: MaoC_dehydratas; pfam01575
1205675000688	active site 2 [active]
1205675000689	active site 1 [active]
1205675000690	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
1205675000691	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675000692	NAD(P) binding site [chemical binding]; other site
1205675000693	active site
1205675000694	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
1205675000695	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1205675000696	dimer interface [polypeptide binding]; other site
1205675000697	active site
1205675000698	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1205675000699	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1205675000700	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
1205675000701	FAD binding site [chemical binding]; other site
1205675000702	substrate binding site [chemical binding]; other site
1205675000703	catalytic residues [active]
1205675000704	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1205675000705	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1205675000706	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
1205675000707	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1205675000708	catalytic loop [active]
1205675000709	iron binding site [ion binding]; other site
1205675000710	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
1205675000711	L-aspartate oxidase; Provisional; Region: PRK06175
1205675000712	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1205675000713	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1205675000714	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1205675000715	putative dimer interface [polypeptide binding]; other site
1205675000716	nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374
1205675000717	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1205675000718	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1205675000719	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1205675000720	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1205675000721	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1205675000722	homotrimer interface [polypeptide binding]; other site
1205675000723	Walker A motif; other site
1205675000724	GTP binding site [chemical binding]; other site
1205675000725	Walker B motif; other site
1205675000726	cobyric acid synthase; Provisional; Region: PRK00784
1205675000727	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1205675000728	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1205675000729	catalytic triad [active]
1205675000730	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675000731	PPE family; Region: PPE; pfam00823
1205675000732	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1205675000733	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1205675000734	putative active site [active]
1205675000735	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1205675000736	putative active site [active]
1205675000737	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
1205675000738	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1205675000739	active site
1205675000740	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
1205675000741	DNA binding site [nucleotide binding]
1205675000742	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1205675000743	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1205675000744	Coenzyme A binding pocket [chemical binding]; other site
1205675000745	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
1205675000746	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1205675000747	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1205675000748	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1205675000749	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1205675000750	intersubunit interface [polypeptide binding]; other site
1205675000751	5-oxoprolinase; Region: PLN02666
1205675000752	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1205675000753	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1205675000754	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1205675000755	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1205675000756	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1205675000757	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1205675000758	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
1205675000759	nucleotide binding site [chemical binding]; other site
1205675000760	acyl-CoA synthetase; Validated; Region: PRK07788
1205675000761	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675000762	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675000763	active site
1205675000764	CoA binding site [chemical binding]; other site
1205675000765	AMP binding site [chemical binding]; other site
1205675000766	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675000767	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675000768	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
1205675000769	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675000770	FAD binding site [chemical binding]; other site
1205675000771	substrate binding site [chemical binding]; other site
1205675000772	catalytic base [active]
1205675000773	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1205675000774	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675000775	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675000776	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1205675000777	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1205675000778	Zn binding site [ion binding]; other site
1205675000779	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
1205675000780	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1205675000781	putative active site [active]
1205675000782	PE family; Region: PE; pfam00934
1205675000783	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675000784	PPE family; Region: PPE; pfam00823
1205675000785	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675000786	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675000787	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1205675000788	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
1205675000789	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675000790	Walker A motif; other site
1205675000791	ATP binding site [chemical binding]; other site
1205675000792	Walker B motif; other site
1205675000793	arginine finger; other site
1205675000794	Protein of unknown function (DUF690); Region: DUF690; pfam05108
1205675000795	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1205675000796	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1205675000797	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1205675000798	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1205675000799	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1205675000800	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675000801	PPE family; Region: PPE; pfam00823
1205675000802	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1205675000803	EspG family; Region: ESX-1_EspG; pfam14011
1205675000804	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1205675000805	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1205675000806	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1205675000807	active site
1205675000808	catalytic residues [active]
1205675000809	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
1205675000810	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1205675000811	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
1205675000812	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
1205675000813	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675000814	S-adenosylmethionine binding site [chemical binding]; other site
1205675000815	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4424
1205675000816	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1205675000817	Sulfatase; Region: Sulfatase; pfam00884
1205675000818	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675000819	PPE family; Region: PPE; pfam00823
1205675000820	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675000821	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675000822	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675000823	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675000824	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675000825	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675000826	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675000827	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675000828	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675000829	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675000830	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675000831	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
1205675000832	putative FMN binding site [chemical binding]; other site
1205675000833	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1205675000834	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1205675000835	active site
1205675000836	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
1205675000837	SnoaL-like domain; Region: SnoaL_4; pfam13577
1205675000838	SnoaL-like domain; Region: SnoaL_3; pfam13474
1205675000839	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
1205675000840	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1205675000841	nucleotide binding site [chemical binding]; other site
1205675000842	Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326
1205675000843	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
1205675000844	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
1205675000845	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
1205675000846	active site
1205675000847	catalytic residues [active]
1205675000848	Muconolactone delta-isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CatC1; COG4829
1205675000849	Muconolactone delta-isomerase; Region: MIase; cl01992
1205675000850	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
1205675000851	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1205675000852	putative active site [active]
1205675000853	catalytic site [active]
1205675000854	putative metal binding site [ion binding]; other site
1205675000855	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1205675000856	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1205675000857	putative substrate binding pocket [chemical binding]; other site
1205675000858	AC domain interface; other site
1205675000859	catalytic triad [active]
1205675000860	AB domain interface; other site
1205675000861	interchain disulfide; other site
1205675000862	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1205675000863	trimer interface [polypeptide binding]; other site
1205675000864	active site
1205675000865	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1205675000866	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1205675000867	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1205675000868	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1205675000869	Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 12775759
1205675000870	Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 12775759
1205675000871	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1205675000872	dimerization interface [polypeptide binding]; other site
1205675000873	putative DNA binding site [nucleotide binding]; other site
1205675000874	putative Zn2+ binding site [ion binding]; other site
1205675000875	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1205675000876	active site residue [active]
1205675000877	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675000878	S-adenosylmethionine binding site [chemical binding]; other site
1205675000879	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675000880	Cytochrome P450; Region: p450; cl12078
1205675000881	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
1205675000882	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675000883	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1205675000884	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1205675000885	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1205675000886	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675000887	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675000888	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1205675000889	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1205675000890	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1205675000891	SnoaL-like domain; Region: SnoaL_2; pfam12680
1205675000892	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1205675000893	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1205675000894	substrate binding site; other site
1205675000895	tetramer interface; other site
1205675000896	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675000897	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675000898	active site
1205675000899	aminotransferase AlaT; Validated; Region: PRK09265
1205675000900	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1205675000901	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675000902	homodimer interface [polypeptide binding]; other site
1205675000903	catalytic residue [active]
1205675000904	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1205675000905	4Fe-4S binding domain; Region: Fer4; pfam00037
1205675000906	Cysteine-rich domain; Region: CCG; pfam02754
1205675000907	Cysteine-rich domain; Region: CCG; pfam02754
1205675000908	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1205675000909	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1205675000910	DNA binding residues [nucleotide binding]
1205675000911	dimerization interface [polypeptide binding]; other site
1205675000912	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
1205675000913	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1205675000914	G1 box; other site
1205675000915	GTP/Mg2+ binding site [chemical binding]; other site
1205675000916	G2 box; other site
1205675000917	Switch I region; other site
1205675000918	G3 box; other site
1205675000919	Switch II region; other site
1205675000920	G4 box; other site
1205675000921	G5 box; other site
1205675000922	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
1205675000923	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1205675000924	G1 box; other site
1205675000925	GTP/Mg2+ binding site [chemical binding]; other site
1205675000926	G2 box; other site
1205675000927	Switch I region; other site
1205675000928	G3 box; other site
1205675000929	Switch II region; other site
1205675000930	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1205675000931	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1205675000932	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1205675000933	nucleotide binding site [chemical binding]; other site
1205675000934	NEF interaction site [polypeptide binding]; other site
1205675000935	SBD interface [polypeptide binding]; other site
1205675000936	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
1205675000937	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1205675000938	dimer interface [polypeptide binding]; other site
1205675000939	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1205675000940	chaperone protein DnaJ; Provisional; Region: PRK14279
1205675000941	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1205675000942	HSP70 interaction site [polypeptide binding]; other site
1205675000943	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1205675000944	Zn binding sites [ion binding]; other site
1205675000945	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1205675000946	dimer interface [polypeptide binding]; other site
1205675000947	Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279
1205675000948	DNA binding residues [nucleotide binding]
1205675000949	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1205675000950	putative dimer interface [polypeptide binding]; other site
1205675000951	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675000952	PPE family; Region: PPE; pfam00823
1205675000953	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675000954	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675000955	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675000956	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675000957	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675000958	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675000959	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675000960	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1205675000961	CoenzymeA binding site [chemical binding]; other site
1205675000962	subunit interaction site [polypeptide binding]; other site
1205675000963	PHB binding site; other site
1205675000964	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1205675000965	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1205675000966	GDP-binding site [chemical binding]; other site
1205675000967	ACT binding site; other site
1205675000968	IMP binding site; other site
1205675000969	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1205675000970	Peptidase family M50; Region: Peptidase_M50; pfam02163
1205675000971	active site
1205675000972	putative substrate binding region [chemical binding]; other site
1205675000973	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
1205675000974	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1205675000975	MgtE intracellular N domain; Region: MgtE_N; pfam03448
1205675000976	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1205675000977	Divalent cation transporter; Region: MgtE; pfam01769
1205675000978	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1205675000979	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1205675000980	active site
1205675000981	intersubunit interface [polypeptide binding]; other site
1205675000982	zinc binding site [ion binding]; other site
1205675000983	Na+ binding site [ion binding]; other site
1205675000984	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1205675000985	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1205675000986	Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833
1205675000987	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
1205675000988	AAA domain; Region: AAA_33; pfam13671
1205675000989	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
1205675000990	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
1205675000991	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
1205675000992	metal ion-dependent adhesion site (MIDAS); other site
1205675000993	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
1205675000994	putative hydrophobic ligand binding site [chemical binding]; other site
1205675000995	MoxR-like ATPases [General function prediction only]; Region: COG0714
1205675000996	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1205675000997	Ligand binding site; other site
1205675000998	metal-binding site
1205675000999	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1205675001000	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1205675001001	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1205675001002	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
1205675001003	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
1205675001004	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1205675001005	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1205675001006	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1205675001007	catalytic loop [active]
1205675001008	iron binding site [ion binding]; other site
1205675001009	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1205675001010	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1205675001011	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1205675001012	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1205675001013	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1205675001014	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1205675001015	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1205675001016	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1205675001017	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1205675001018	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1205675001019	dimerization interface [polypeptide binding]; other site
1205675001020	Uncharacterized conserved protein [Function unknown]; Region: COG3360
1205675001021	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1205675001022	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1205675001023	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1205675001024	active site
1205675001025	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1205675001026	Clp amino terminal domain; Region: Clp_N; pfam02861
1205675001027	Clp amino terminal domain; Region: Clp_N; pfam02861
1205675001028	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675001029	Walker A motif; other site
1205675001030	ATP binding site [chemical binding]; other site
1205675001031	Walker B motif; other site
1205675001032	arginine finger; other site
1205675001033	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675001034	Walker A motif; other site
1205675001035	ATP binding site [chemical binding]; other site
1205675001036	Walker B motif; other site
1205675001037	arginine finger; other site
1205675001038	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1205675001039	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1205675001040	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1205675001041	heme-binding site [chemical binding]; other site
1205675001042	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
1205675001043	FAD binding pocket [chemical binding]; other site
1205675001044	FAD binding motif [chemical binding]; other site
1205675001045	phosphate binding motif [ion binding]; other site
1205675001046	beta-alpha-beta structure motif; other site
1205675001047	NAD binding pocket [chemical binding]; other site
1205675001048	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1205675001049	cyclase homology domain; Region: CHD; cd07302
1205675001050	nucleotidyl binding site; other site
1205675001051	metal binding site [ion binding]; metal-binding site
1205675001052	dimer interface [polypeptide binding]; other site
1205675001053	Predicted ATPase [General function prediction only]; Region: COG3903
1205675001054	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1205675001055	Walker A motif; other site
1205675001056	ATP binding site [chemical binding]; other site
1205675001057	Walker B motif; other site
1205675001058	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1205675001059	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1205675001060	DNA binding residues [nucleotide binding]
1205675001061	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675001062	PPE family; Region: PPE; pfam00823
1205675001063	Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) [Nucleotide transport and metabolism]; Region: PurT; COG0027
1205675001064	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1205675001065	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1205675001066	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
1205675001067	active site residue [active]
1205675001068	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
1205675001069	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1205675001070	homodimer interface [polypeptide binding]; other site
1205675001071	substrate-cofactor binding pocket; other site
1205675001072	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675001073	catalytic residue [active]
1205675001074	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1205675001075	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1205675001076	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1205675001077	Evidence 4 : Homologs of previously reported genes of unknown function
1205675001078	Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046
1205675001079	Evidence 4 : Homologs of previously reported genes of unknown function
1205675001080	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1205675001081	Beta-lactamase; Region: Beta-lactamase; pfam00144
1205675001082	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
1205675001083	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675001084	FAD binding site [chemical binding]; other site
1205675001085	substrate binding pocket [chemical binding]; other site
1205675001086	catalytic base [active]
1205675001087	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
1205675001088	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1205675001089	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1205675001090	acyl-CoA synthetase; Validated; Region: PRK05850
1205675001091	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1205675001092	acyl-activating enzyme (AAE) consensus motif; other site
1205675001093	active site
1205675001094	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
1205675001095	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675001096	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1205675001097	active site
1205675001098	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1205675001099	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1205675001100	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675001101	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675001102	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1205675001103	active site
1205675001104	Acyl transferase domain; Region: Acyl_transf_1; cl08282
1205675001105	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1205675001106	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1205675001107	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675001108	Thioesterase; Region: PKS_TE; smart00824
1205675001109	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1205675001110	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
1205675001111	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1205675001112	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1205675001113	phosphate acetyltransferase; Reviewed; Region: PRK05632
1205675001114	DRTGG domain; Region: DRTGG; pfam07085
1205675001115	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1205675001116	propionate/acetate kinase; Provisional; Region: PRK12379
1205675001117	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1205675001118	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1205675001119	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1205675001120	active site
1205675001121	ATP binding site [chemical binding]; other site
1205675001122	substrate binding site [chemical binding]; other site
1205675001123	activation loop (A-loop); other site
1205675001124	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1205675001125	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1205675001126	substrate binding pocket [chemical binding]; other site
1205675001127	membrane-bound complex binding site; other site
1205675001128	hinge residues; other site
1205675001129	NUDIX domain; Region: NUDIX; pfam00293
1205675001130	nudix motif; other site
1205675001131	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1205675001132	thiamine phosphate binding site [chemical binding]; other site
1205675001133	active site
1205675001134	pyrophosphate binding site [ion binding]; other site
1205675001135	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1205675001136	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1205675001137	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1205675001138	thiS-thiF/thiG interaction site; other site
1205675001139	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1205675001140	ThiS interaction site; other site
1205675001141	putative active site [active]
1205675001142	tetramer interface [polypeptide binding]; other site
1205675001143	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
1205675001144	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1205675001145	PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH.  Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816
1205675001146	PA/protease or protease-like domain interface [polypeptide binding]; other site
1205675001147	M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876
1205675001148	active site
1205675001149	metal binding site [ion binding]; metal-binding site
1205675001150	Predicted metalloprotease [General function prediction only]; Region: COG2321
1205675001151	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1205675001152	Zn binding site [ion binding]; other site
1205675001153	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1205675001154	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1205675001155	dimer interface [polypeptide binding]; other site
1205675001156	substrate binding site [chemical binding]; other site
1205675001157	ATP binding site [chemical binding]; other site
1205675001158	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1205675001159	ThiC-associated domain; Region: ThiC-associated; pfam13667
1205675001160	ThiC family; Region: ThiC; pfam01964
1205675001161	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1205675001162	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
1205675001163	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1205675001164	motif II; other site
1205675001165	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1205675001166	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1205675001167	putative catalytic site [active]
1205675001168	putative phosphate binding site [ion binding]; other site
1205675001169	active site
1205675001170	metal binding site A [ion binding]; metal-binding site
1205675001171	DNA binding site [nucleotide binding]
1205675001172	putative AP binding site [nucleotide binding]; other site
1205675001173	putative metal binding site B [ion binding]; other site
1205675001174	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1205675001175	active site
1205675001176	catalytic residues [active]
1205675001177	metal binding site [ion binding]; metal-binding site
1205675001178	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
1205675001179	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1205675001180	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1205675001181	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1205675001182	E-class dimer interface [polypeptide binding]; other site
1205675001183	P-class dimer interface [polypeptide binding]; other site
1205675001184	active site
1205675001185	Cu2+ binding site [ion binding]; other site
1205675001186	Zn2+ binding site [ion binding]; other site
1205675001187	carboxylate-amine ligase; Provisional; Region: PRK13517
1205675001188	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
1205675001189	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
1205675001190	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
1205675001191	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
1205675001192	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675001193	Walker A motif; other site
1205675001194	ATP binding site [chemical binding]; other site
1205675001195	Walker B motif; other site
1205675001196	arginine finger; other site
1205675001197	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675001198	Walker A motif; other site
1205675001199	ATP binding site [chemical binding]; other site
1205675001200	Walker B motif; other site
1205675001201	arginine finger; other site
1205675001202	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1205675001203	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1205675001204	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
1205675001205	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1205675001206	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1205675001207	dimer interface [polypeptide binding]; other site
1205675001208	putative functional site; other site
1205675001209	putative MPT binding site; other site
1205675001210	short chain dehydrogenase; Provisional; Region: PRK06197
1205675001211	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1205675001212	putative NAD(P) binding site [chemical binding]; other site
1205675001213	active site
1205675001214	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1205675001215	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1205675001216	ring oligomerisation interface [polypeptide binding]; other site
1205675001217	ATP/Mg binding site [chemical binding]; other site
1205675001218	stacking interactions; other site
1205675001219	hinge regions; other site
1205675001220	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1205675001221	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675001222	PPE family; Region: PPE; pfam00823
1205675001223	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1205675001224	DinB superfamily; Region: DinB_2; pfam12867
1205675001225	putative anti-sigmaE protein; Provisional; Region: PRK13920
1205675001226	Anti-sigma-K factor rskA; Region: RskA; pfam10099
1205675001227	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1205675001228	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1205675001229	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1205675001230	DNA binding residues [nucleotide binding]
1205675001231	Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752
1205675001232	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1205675001233	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675001234	S-adenosylmethionine binding site [chemical binding]; other site
1205675001235	Protein of unknown function (DUF1365); Region: DUF1365; cl17838
1205675001236	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
1205675001237	Transport protein; Region: actII; TIGR00833
1205675001238	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1205675001239	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675001240	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675001241	PPE family; Region: PPE; pfam00823
1205675001242	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675001243	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
1205675001244	enoyl-CoA hydratase; Provisional; Region: PRK12478
1205675001245	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675001246	substrate binding site [chemical binding]; other site
1205675001247	oxyanion hole (OAH) forming residues; other site
1205675001248	trimer interface [polypeptide binding]; other site
1205675001249	PemK-like protein; Region: PemK; pfam02452
1205675001250	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1205675001251	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1205675001252	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1205675001253	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1205675001254	NAD(P) binding site [chemical binding]; other site
1205675001255	catalytic residues [active]
1205675001256	Protein of unknown function (DUF779); Region: DUF779; cl01432
1205675001257	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
1205675001258	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1205675001259	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1205675001260	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1205675001261	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1205675001262	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1205675001263	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1205675001264	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1205675001265	non-specific DNA binding site [nucleotide binding]; other site
1205675001266	salt bridge; other site
1205675001267	sequence-specific DNA binding site [nucleotide binding]; other site
1205675001268	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1205675001269	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1205675001270	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1205675001271	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
1205675001272	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1205675001273	active site
1205675001274	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1205675001275	active site 2 [active]
1205675001276	isocitrate lyase; Provisional; Region: PRK15063
1205675001277	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cd06556
1205675001278	oligomerization interface [polypeptide binding]; other site
1205675001279	active site
1205675001280	metal binding site [ion binding]; metal-binding site
1205675001281	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
1205675001282	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1205675001283	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1205675001284	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1205675001285	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675001286	S-adenosylmethionine binding site [chemical binding]; other site
1205675001287	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1205675001288	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1205675001289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675001290	S-adenosylmethionine binding site [chemical binding]; other site
1205675001291	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
1205675001292	UbiA prenyltransferase family; Region: UbiA; pfam01040
1205675001293	UbiA prenyltransferase family; Region: UbiA; pfam01040
1205675001294	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675001295	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675001296	Predicted membrane protein [Function unknown]; Region: COG2733
1205675001297	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1205675001298	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1205675001299	non-specific DNA binding site [nucleotide binding]; other site
1205675001300	salt bridge; other site
1205675001301	sequence-specific DNA binding site [nucleotide binding]; other site
1205675001302	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
1205675001303	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
1205675001304	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1205675001305	intersubunit interface [polypeptide binding]; other site
1205675001306	active site
1205675001307	catalytic residue [active]
1205675001308	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1205675001309	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1205675001310	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
1205675001311	putative active site [active]
1205675001312	catalytic triad [active]
1205675001313	putative dimer interface [polypeptide binding]; other site
1205675001314	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
1205675001315	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
1205675001316	FAD binding domain; Region: FAD_binding_4; pfam01565
1205675001317	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1205675001318	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1205675001319	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1205675001320	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
1205675001321	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1205675001322	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1205675001323	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675001324	NAD(P) binding site [chemical binding]; other site
1205675001325	active site
1205675001326	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1205675001327	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1205675001328	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1205675001329	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
1205675001330	putative ADP-binding pocket [chemical binding]; other site
1205675001331	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1205675001332	L-lysine exporter; Region: 2a75; TIGR00948
1205675001333	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1205675001334	catalytic core [active]
1205675001335	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
1205675001336	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1205675001337	dimer interface [polypeptide binding]; other site
1205675001338	phosphorylation site [posttranslational modification]
1205675001339	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1205675001340	ATP binding site [chemical binding]; other site
1205675001341	Mg2+ binding site [ion binding]; other site
1205675001342	G-X-G motif; other site
1205675001343	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1205675001344	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1205675001345	active site
1205675001346	phosphorylation site [posttranslational modification]
1205675001347	intermolecular recognition site; other site
1205675001348	dimerization interface [polypeptide binding]; other site
1205675001349	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1205675001350	DNA binding site [nucleotide binding]
1205675001351	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
1205675001352	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1205675001353	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1205675001354	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1205675001355	DNA-binding site [nucleotide binding]; DNA binding site
1205675001356	FCD domain; Region: FCD; pfam07729
1205675001357	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1205675001358	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1205675001359	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1205675001360	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1205675001361	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1205675001362	Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046
1205675001363	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1205675001364	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1205675001365	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1205675001366	DNA binding domain, excisionase family; Region: excise; TIGR01764
1205675001367	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1205675001368	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
1205675001369	putative NAD(P) binding site [chemical binding]; other site
1205675001370	active site
1205675001371	putative substrate binding site [chemical binding]; other site
1205675001372	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1205675001373	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
1205675001374	putative acyl-acceptor binding pocket; other site
1205675001375	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1205675001376	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1205675001377	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675001378	S-adenosylmethionine binding site [chemical binding]; other site
1205675001379	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1205675001380	active site
1205675001381	catalytic site [active]
1205675001382	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1205675001383	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
1205675001384	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1205675001385	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1205675001386	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1205675001387	glutamyl-tRNA reductase; Region: hemA; TIGR01035
1205675001388	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1205675001389	tRNA; other site
1205675001390	putative tRNA binding site [nucleotide binding]; other site
1205675001391	putative NADP binding site [chemical binding]; other site
1205675001392	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1205675001393	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1205675001394	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
1205675001395	domain interfaces; other site
1205675001396	active site
1205675001397	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
1205675001398	active site
1205675001399	homodimer interface [polypeptide binding]; other site
1205675001400	SAM binding site [chemical binding]; other site
1205675001401	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1205675001402	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1205675001403	active site
1205675001404	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1205675001405	dimer interface [polypeptide binding]; other site
1205675001406	active site
1205675001407	Schiff base residues; other site
1205675001408	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675001409	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675001410	active site
1205675001411	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1205675001412	anti sigma factor interaction site; other site
1205675001413	regulatory phosphorylation site [posttranslational modification]; other site
1205675001414	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1205675001415	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1205675001416	active site
1205675001417	catalytic triad [active]
1205675001418	oxyanion hole [active]
1205675001419	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
1205675001420	PE family; Region: PE; pfam00934
1205675001421	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1205675001422	Domain of unknown function (DUF385); Region: DUF385; cl04387
1205675001423	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1205675001424	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1205675001425	inhibitor-cofactor binding pocket; inhibition site
1205675001426	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675001427	catalytic residue [active]
1205675001428	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1205675001429	catalytic core [active]
1205675001430	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1205675001431	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1205675001432	catalytic residues [active]
1205675001433	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1205675001434	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1205675001435	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
1205675001436	ResB-like family; Region: ResB; pfam05140
1205675001437	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1205675001438	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1205675001439	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1205675001440	P-loop; other site
1205675001441	Magnesium ion binding site [ion binding]; other site
1205675001442	3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747
1205675001443	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1205675001444	dimer interface [polypeptide binding]; other site
1205675001445	active site
1205675001446	CoA binding pocket [chemical binding]; other site
1205675001447	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
1205675001448	UbiA prenyltransferase family; Region: UbiA; pfam01040
1205675001449	5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823
1205675001450	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1205675001451	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675001452	NAD(P) binding site [chemical binding]; other site
1205675001453	active site
1205675001454	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1205675001455	Ligand binding site; other site
1205675001456	Putative Catalytic site; other site
1205675001457	DXD motif; other site
1205675001458	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222
1205675001459	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
1205675001460	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675001461	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675001462	acyl-activating enzyme (AAE) consensus motif; other site
1205675001463	acyl-activating enzyme (AAE) consensus motif; other site
1205675001464	AMP binding site [chemical binding]; other site
1205675001465	active site
1205675001466	CoA binding site [chemical binding]; other site
1205675001467	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
1205675001468	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1205675001469	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1205675001470	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1205675001471	active site
1205675001472	short chain dehydrogenase; Provisional; Region: PRK05866
1205675001473	classical (c) SDRs; Region: SDR_c; cd05233
1205675001474	NAD(P) binding site [chemical binding]; other site
1205675001475	active site
1205675001476	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675001477	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1205675001478	substrate binding site [chemical binding]; other site
1205675001479	oxyanion hole (OAH) forming residues; other site
1205675001480	trimer interface [polypeptide binding]; other site
1205675001481	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
1205675001482	putative active site [active]
1205675001483	homotetrameric interface [polypeptide binding]; other site
1205675001484	metal binding site [ion binding]; metal-binding site
1205675001485	Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [General function prediction only]; Region: COG5302
1205675001486	acyl-CoA synthetase; Validated; Region: PRK06188
1205675001487	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1205675001488	putative active site [active]
1205675001489	putative CoA binding site [chemical binding]; other site
1205675001490	putative AMP binding site [chemical binding]; other site
1205675001491	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1205675001492	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1205675001493	active site
1205675001494	O-succinylbenzoate synthase; Provisional; Region: PRK02901
1205675001495	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1205675001496	active site
1205675001497	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675001498	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1205675001499	TAP-like protein; Region: Abhydrolase_4; pfam08386
1205675001500	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1205675001501	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1205675001502	dimer interface [polypeptide binding]; other site
1205675001503	tetramer interface [polypeptide binding]; other site
1205675001504	PYR/PP interface [polypeptide binding]; other site
1205675001505	TPP binding site [chemical binding]; other site
1205675001506	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1205675001507	TPP-binding site; other site
1205675001508	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
1205675001509	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1205675001510	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1205675001511	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1205675001512	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675001513	S-adenosylmethionine binding site [chemical binding]; other site
1205675001514	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1205675001515	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1205675001516	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675001517	S-adenosylmethionine binding site [chemical binding]; other site
1205675001518	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1205675001519	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1205675001520	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1205675001521	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1205675001522	substrate binding pocket [chemical binding]; other site
1205675001523	chain length determination region; other site
1205675001524	substrate-Mg2+ binding site; other site
1205675001525	catalytic residues [active]
1205675001526	aspartate-rich region 1; other site
1205675001527	active site lid residues [active]
1205675001528	aspartate-rich region 2; other site
1205675001529	heat shock protein HtpX; Provisional; Region: PRK03072
1205675001530	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439
1205675001531	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1205675001532	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1205675001533	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1205675001534	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1205675001535	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1205675001536	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1205675001537	O-methyltransferase; Region: Methyltransf_2; pfam00891
1205675001538	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675001539	Cytochrome P450; Region: p450; cl12078
1205675001540	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
1205675001541	ATP cone domain; Region: ATP-cone; pfam03477
1205675001542	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
1205675001543	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
1205675001544	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
1205675001545	active site
1205675001546	dimer interface [polypeptide binding]; other site
1205675001547	effector binding site; other site
1205675001548	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1205675001549	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1205675001550	active site
1205675001551	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1205675001552	nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484
1205675001553	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1205675001554	active site
1205675001555	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
1205675001556	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1205675001557	putative active site [active]
1205675001558	putative metal binding site [ion binding]; other site
1205675001559	hypothetical protein; Provisional; Region: PRK07588
1205675001560	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1205675001561	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1205675001562	dimerization interface [polypeptide binding]; other site
1205675001563	putative DNA binding site [nucleotide binding]; other site
1205675001564	putative Zn2+ binding site [ion binding]; other site
1205675001565	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1205675001566	putative hydrophobic ligand binding site [chemical binding]; other site
1205675001567	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1205675001568	TIGR03086 family protein; Region: TIGR03086
1205675001569	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1205675001570	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1205675001571	PE family; Region: PE; pfam00934
1205675001572	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
1205675001573	Uncharacterized conserved protein [Function unknown]; Region: COG1656
1205675001574	Protein of unknown function DUF82; Region: DUF82; pfam01927
1205675001575	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1205675001576	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1205675001577	putative active site [active]
1205675001578	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
1205675001579	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
1205675001580	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
1205675001581	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
1205675001582	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1205675001583	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1205675001584	DNA-binding site [nucleotide binding]; DNA binding site
1205675001585	FCD domain; Region: FCD; pfam07729
1205675001586	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1205675001587	Permease; Region: Permease; pfam02405
1205675001588	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1205675001589	Permease; Region: Permease; pfam02405
1205675001590	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675001591	mce related protein; Region: MCE; pfam02470
1205675001592	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1205675001593	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1205675001594	mce related protein; Region: MCE; pfam02470
1205675001595	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1205675001596	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675001597	mce related protein; Region: MCE; pfam02470
1205675001598	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675001599	mce related protein; Region: MCE; pfam02470
1205675001600	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675001601	mce related protein; Region: MCE; pfam02470
1205675001602	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675001603	mce related protein; Region: MCE; pfam02470
1205675001604	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1205675001605	oligomeric interface; other site
1205675001606	putative active site [active]
1205675001607	homodimer interface [polypeptide binding]; other site
1205675001608	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1205675001609	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
1205675001610	AAA domain; Region: AAA_14; pfam13173
1205675001611	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1205675001612	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
1205675001613	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pr : putative regulator
1205675001614	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pr : putative regulator
1205675001615	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
1205675001616	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
1205675001617	putative active site [active]
1205675001618	SEC-C motif; Region: SEC-C; pfam02810
1205675001619	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
1205675001620	putative active site [active]
1205675001621	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
1205675001622	dimer interface [polypeptide binding]; other site
1205675001623	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
1205675001624	active site
1205675001625	galactokinase; Provisional; Region: PRK00555
1205675001626	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1205675001627	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1205675001628	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
1205675001629	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
1205675001630	putative active site [active]
1205675001631	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1205675001632	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1205675001633	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1205675001634	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1205675001635	oligomeric interface; other site
1205675001636	putative active site [active]
1205675001637	homodimer interface [polypeptide binding]; other site
1205675001638	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
1205675001639	FIST N domain; Region: FIST; pfam08495
1205675001640	FIST C domain; Region: FIST_C; pfam10442
1205675001641	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
1205675001642	AAA domain; Region: AAA_30; pfam13604
1205675001643	Family description; Region: UvrD_C_2; pfam13538
1205675001644	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
1205675001645	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1205675001646	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
1205675001647	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1205675001648	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1205675001649	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675001650	substrate binding site [chemical binding]; other site
1205675001651	oxyanion hole (OAH) forming residues; other site
1205675001652	trimer interface [polypeptide binding]; other site
1205675001653	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1205675001654	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1205675001655	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1205675001656	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1205675001657	active site
1205675001658	catalytic site [active]
1205675001659	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
1205675001660	active site
1205675001661	catalytic site [active]
1205675001662	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1205675001663	active site
1205675001664	catalytic site [active]
1205675001665	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1205675001666	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1205675001667	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1205675001668	putative homodimer interface [polypeptide binding]; other site
1205675001669	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1205675001670	heterodimer interface [polypeptide binding]; other site
1205675001671	homodimer interface [polypeptide binding]; other site
1205675001672	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1205675001673	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1205675001674	23S rRNA interface [nucleotide binding]; other site
1205675001675	L7/L12 interface [polypeptide binding]; other site
1205675001676	putative thiostrepton binding site; other site
1205675001677	L25 interface [polypeptide binding]; other site
1205675001678	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1205675001679	mRNA/rRNA interface [nucleotide binding]; other site
1205675001680	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1205675001681	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675001682	S-adenosylmethionine binding site [chemical binding]; other site
1205675001683	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1205675001684	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1205675001685	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675001686	S-adenosylmethionine binding site [chemical binding]; other site
1205675001687	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1205675001688	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1205675001689	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675001690	S-adenosylmethionine binding site [chemical binding]; other site
1205675001691	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1205675001692	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1205675001693	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675001694	S-adenosylmethionine binding site [chemical binding]; other site
1205675001695	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675001696	TAP-like protein; Region: Abhydrolase_4; pfam08386
1205675001697	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1205675001698	ABC1 family; Region: ABC1; cl17513
1205675001699	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
1205675001700	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
1205675001701	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
1205675001702	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
1205675001703	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1205675001704	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1205675001705	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1205675001706	23S rRNA interface [nucleotide binding]; other site
1205675001707	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1205675001708	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1205675001709	core dimer interface [polypeptide binding]; other site
1205675001710	peripheral dimer interface [polypeptide binding]; other site
1205675001711	L10 interface [polypeptide binding]; other site
1205675001712	L11 interface [polypeptide binding]; other site
1205675001713	putative EF-Tu interaction site [polypeptide binding]; other site
1205675001714	putative EF-G interaction site [polypeptide binding]; other site
1205675001715	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675001716	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675001717	WHG domain; Region: WHG; pfam13305
1205675001718	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
1205675001719	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
1205675001720	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1205675001721	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1205675001722	Walker A/P-loop; other site
1205675001723	ATP binding site [chemical binding]; other site
1205675001724	Q-loop/lid; other site
1205675001725	ABC transporter signature motif; other site
1205675001726	Walker B; other site
1205675001727	D-loop; other site
1205675001728	H-loop/switch region; other site
1205675001729	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1205675001730	putative active site [active]
1205675001731	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1205675001732	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
1205675001733	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1205675001734	Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15993073
1205675001735	Evidence 5 : No homology to any previously reported sequences; PubMedId : 12657046, 15993073
1205675001736	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1205675001737	Sulfatase; Region: Sulfatase; pfam00884
1205675001738	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1205675001739	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1205675001740	oligomeric interface; other site
1205675001741	putative active site [active]
1205675001742	homodimer interface [polypeptide binding]; other site
1205675001743	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1205675001744	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1205675001745	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1205675001746	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1205675001747	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1205675001748	RPB10 interaction site [polypeptide binding]; other site
1205675001749	RPB1 interaction site [polypeptide binding]; other site
1205675001750	RPB11 interaction site [polypeptide binding]; other site
1205675001751	RPB3 interaction site [polypeptide binding]; other site
1205675001752	RPB12 interaction site [polypeptide binding]; other site
1205675001753	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1205675001754	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1205675001755	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1205675001756	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1205675001757	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
1205675001758	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1205675001759	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1205675001760	G-loop; other site
1205675001761	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1205675001762	DNA binding site [nucleotide binding]
1205675001763	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1205675001764	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734
1205675001765	endonuclease IV; Provisional; Region: PRK01060
1205675001766	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1205675001767	AP (apurinic/apyrimidinic) site pocket; other site
1205675001768	DNA interaction; other site
1205675001769	Metal-binding active site; metal-binding site
1205675001770	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
1205675001771	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1205675001772	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
1205675001773	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675001774	active site
1205675001775	enoyl-CoA hydratase; Provisional; Region: PRK12478
1205675001776	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675001777	substrate binding site [chemical binding]; other site
1205675001778	oxyanion hole (OAH) forming residues; other site
1205675001779	trimer interface [polypeptide binding]; other site
1205675001780	PaaX-like protein; Region: PaaX; pfam07848
1205675001781	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1205675001782	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1205675001783	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675001784	substrate binding site [chemical binding]; other site
1205675001785	oxyanion hole (OAH) forming residues; other site
1205675001786	trimer interface [polypeptide binding]; other site
1205675001787	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1205675001788	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1205675001789	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952
1205675001790	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
1205675001791	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
1205675001792	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675001793	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675001794	WHG domain; Region: WHG; pfam13305
1205675001795	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1205675001796	S17 interaction site [polypeptide binding]; other site
1205675001797	S8 interaction site; other site
1205675001798	16S rRNA interaction site [nucleotide binding]; other site
1205675001799	streptomycin interaction site [chemical binding]; other site
1205675001800	23S rRNA interaction site [nucleotide binding]; other site
1205675001801	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1205675001802	30S ribosomal protein S7; Validated; Region: PRK05302
1205675001803	elongation factor G; Reviewed; Region: PRK00007
1205675001804	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1205675001805	G1 box; other site
1205675001806	putative GEF interaction site [polypeptide binding]; other site
1205675001807	GTP/Mg2+ binding site [chemical binding]; other site
1205675001808	Switch I region; other site
1205675001809	G2 box; other site
1205675001810	G3 box; other site
1205675001811	Switch II region; other site
1205675001812	G4 box; other site
1205675001813	G5 box; other site
1205675001814	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1205675001815	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1205675001816	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1205675001817	elongation factor Tu; Reviewed; Region: PRK00049
1205675001818	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1205675001819	G1 box; other site
1205675001820	GEF interaction site [polypeptide binding]; other site
1205675001821	GTP/Mg2+ binding site [chemical binding]; other site
1205675001822	Switch I region; other site
1205675001823	G2 box; other site
1205675001824	G3 box; other site
1205675001825	Switch II region; other site
1205675001826	G4 box; other site
1205675001827	G5 box; other site
1205675001828	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
1205675001829	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1205675001830	Antibiotic Binding Site [chemical binding]; other site
1205675001831	Short C-terminal domain; Region: SHOCT; pfam09851
1205675001832	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
1205675001833	classical (c) SDRs; Region: SDR_c; cd05233
1205675001834	NAD(P) binding site [chemical binding]; other site
1205675001835	active site
1205675001836	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1205675001837	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1205675001838	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427
1205675001839	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1205675001840	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675001841	putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967
1205675001842	mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962
1205675001843	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1205675001844	FeS/SAM binding site; other site
1205675001845	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1205675001846	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
1205675001847	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1205675001848	phosphate binding site [ion binding]; other site
1205675001849	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
1205675001850	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
1205675001851	catalytic residues [active]
1205675001852	catalytic nucleophile [active]
1205675001853	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1205675001854	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1205675001855	Probable transposase; Region: OrfB_IS605; pfam01385
1205675001856	mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964
1205675001857	mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965
1205675001858	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1205675001859	Probable Catalytic site; other site
1205675001860	metal-binding site
1205675001861	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
1205675001862	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1205675001863	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1205675001864	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1205675001865	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1205675001866	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1205675001867	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1205675001868	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1205675001869	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1205675001870	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1205675001871	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1205675001872	putative translocon binding site; other site
1205675001873	protein-rRNA interface [nucleotide binding]; other site
1205675001874	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1205675001875	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1205675001876	G-X-X-G motif; other site
1205675001877	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1205675001878	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1205675001879	23S rRNA interface [nucleotide binding]; other site
1205675001880	5S rRNA interface [nucleotide binding]; other site
1205675001881	putative antibiotic binding site [chemical binding]; other site
1205675001882	L25 interface [polypeptide binding]; other site
1205675001883	L27 interface [polypeptide binding]; other site
1205675001884	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1205675001885	putative translocon interaction site; other site
1205675001886	23S rRNA interface [nucleotide binding]; other site
1205675001887	signal recognition particle (SRP54) interaction site; other site
1205675001888	L23 interface [polypeptide binding]; other site
1205675001889	trigger factor interaction site; other site
1205675001890	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1205675001891	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1205675001892	Sulfatase; Region: Sulfatase; pfam00884
1205675001893	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353
1205675001894	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1205675001895	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1205675001896	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1205675001897	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1205675001898	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1205675001899	RNA binding site [nucleotide binding]; other site
1205675001900	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1205675001901	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1205675001902	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1205675001903	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1205675001904	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1205675001905	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1205675001906	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1205675001907	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1205675001908	5S rRNA interface [nucleotide binding]; other site
1205675001909	23S rRNA interface [nucleotide binding]; other site
1205675001910	L5 interface [polypeptide binding]; other site
1205675001911	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1205675001912	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1205675001913	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1205675001914	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1205675001915	23S rRNA binding site [nucleotide binding]; other site
1205675001916	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1205675001917	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
1205675001918	tandem repeat interface [polypeptide binding]; other site
1205675001919	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1205675001920	oligomer interface [polypeptide binding]; other site
1205675001921	active site residues [active]
1205675001922	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1205675001923	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1205675001924	tandem repeat interface [polypeptide binding]; other site
1205675001925	oligomer interface [polypeptide binding]; other site
1205675001926	active site residues [active]
1205675001927	Leucine carboxyl methyltransferase; Region: LCM; cl01306
1205675001928	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675001929	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1205675001930	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675001931	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1205675001932	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1205675001933	intersubunit interface [polypeptide binding]; other site
1205675001934	active site
1205675001935	Zn2+ binding site [ion binding]; other site
1205675001936	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1205675001937	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1205675001938	NAD binding site [chemical binding]; other site
1205675001939	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1205675001940	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1205675001941	nucleotide binding site [chemical binding]; other site
1205675001942	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1205675001943	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1205675001944	Coenzyme A binding pocket [chemical binding]; other site
1205675001945	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675001946	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1205675001947	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1205675001948	SecY translocase; Region: SecY; pfam00344
1205675001949	adenylate kinase; Reviewed; Region: adk; PRK00279
1205675001950	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1205675001951	AMP-binding site [chemical binding]; other site
1205675001952	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1205675001953	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1205675001954	active site
1205675001955	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
1205675001956	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1205675001957	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1205675001958	DNA binding residues [nucleotide binding]
1205675001959	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1205675001960	Putative zinc-finger; Region: zf-HC2; pfam13490
1205675001961	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1205675001962	MarR family; Region: MarR; pfam01047
1205675001963	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1205675001964	TIGR03086 family protein; Region: TIGR03086
1205675001965	Domain of unknown function (DUF4226); Region: DUF4226; pfam10774
1205675001966	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1205675001967	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1205675001968	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675001969	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675001970	active site
1205675001971	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1205675001972	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1205675001973	tetrameric interface [polypeptide binding]; other site
1205675001974	NAD binding site [chemical binding]; other site
1205675001975	catalytic residues [active]
1205675001976	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1205675001977	catalytic core [active]
1205675001978	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675001979	PPE family; Region: PPE; pfam00823
1205675001980	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675001981	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1205675001982	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1205675001983	active site
1205675001984	phosphorylation site [posttranslational modification]
1205675001985	intermolecular recognition site; other site
1205675001986	dimerization interface [polypeptide binding]; other site
1205675001987	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1205675001988	DNA binding site [nucleotide binding]
1205675001989	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1205675001990	dimerization interface [polypeptide binding]; other site
1205675001991	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1205675001992	dimer interface [polypeptide binding]; other site
1205675001993	phosphorylation site [posttranslational modification]
1205675001994	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1205675001995	ATP binding site [chemical binding]; other site
1205675001996	Mg2+ binding site [ion binding]; other site
1205675001997	G-X-G motif; other site
1205675001998	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1205675001999	nucleotide binding site/active site [active]
1205675002000	HIT family signature motif; other site
1205675002001	catalytic residue [active]
1205675002002	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
1205675002003	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
1205675002004	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1205675002005	NAD binding site [chemical binding]; other site
1205675002006	catalytic Zn binding site [ion binding]; other site
1205675002007	substrate binding site [chemical binding]; other site
1205675002008	structural Zn binding site [ion binding]; other site
1205675002009	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1205675002010	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1205675002011	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
1205675002012	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675002013	Cytochrome P450; Region: p450; cl12078
1205675002014	short chain dehydrogenase; Provisional; Region: PRK07775
1205675002015	classical (c) SDRs; Region: SDR_c; cd05233
1205675002016	NAD(P) binding site [chemical binding]; other site
1205675002017	active site
1205675002018	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675002019	Cytochrome P450; Region: p450; cl12078
1205675002020	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675002021	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
1205675002022	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
1205675002023	NAD binding site [chemical binding]; other site
1205675002024	catalytic residues [active]
1205675002025	short chain dehydrogenase; Provisional; Region: PRK07774
1205675002026	classical (c) SDRs; Region: SDR_c; cd05233
1205675002027	NAD(P) binding site [chemical binding]; other site
1205675002028	active site
1205675002029	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1205675002030	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1205675002031	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1205675002032	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1205675002033	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1205675002034	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1205675002035	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1205675002036	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1205675002037	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1205675002038	Predicted esterase [General function prediction only]; Region: COG0627
1205675002039	S-formylglutathione hydrolase; Region: PLN02442
1205675002040	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1205675002041	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
1205675002042	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
1205675002043	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1205675002044	tetramer interface [polypeptide binding]; other site
1205675002045	active site
1205675002046	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675002047	Cytochrome P450; Region: p450; cl12078
1205675002048	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1205675002049	ATP binding site [chemical binding]; other site
1205675002050	active site
1205675002051	substrate binding site [chemical binding]; other site
1205675002052	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1205675002053	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1205675002054	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1205675002055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675002056	putative substrate translocation pore; other site
1205675002057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675002058	Predicted deacetylase [General function prediction only]; Region: COG3233
1205675002059	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
1205675002060	putative active site [active]
1205675002061	putative Zn binding site [ion binding]; other site
1205675002062	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1205675002063	FAD binding domain; Region: FAD_binding_2; pfam00890
1205675002064	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1205675002065	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
1205675002066	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1205675002067	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1205675002068	putative active site [active]
1205675002069	catalytic triad [active]
1205675002070	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1205675002071	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1205675002072	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1205675002073	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
1205675002074	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1205675002075	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1205675002076	DNA-binding site [nucleotide binding]; DNA binding site
1205675002077	UTRA domain; Region: UTRA; pfam07702
1205675002078	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1205675002079	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1205675002080	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1205675002081	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1205675002082	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1205675002083	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1205675002084	MULE transposase domain; Region: MULE; pfam10551
1205675002085	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1205675002086	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1205675002087	putative transposase OrfB; Reviewed; Region: PHA02517
1205675002088	HTH-like domain; Region: HTH_21; pfam13276
1205675002089	Integrase core domain; Region: rve; pfam00665
1205675002090	Integrase core domain; Region: rve_3; pfam13683
1205675002091	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1205675002092	Transposase; Region: HTH_Tnp_1; cl17663
1205675002093	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1205675002094	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1205675002095	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1205675002096	Uncharacterized protein, linocin/CFP29 homolog [Function unknown]; Region: COG1659
1205675002097	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
1205675002098	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
1205675002099	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
1205675002100	active site
1205675002101	metal binding site [ion binding]; metal-binding site
1205675002102	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1205675002103	active site
1205675002104	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1205675002105	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1205675002106	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1205675002107	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1205675002108	dimerization interface [polypeptide binding]; other site
1205675002109	ATP binding site [chemical binding]; other site
1205675002110	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1205675002111	dimerization interface [polypeptide binding]; other site
1205675002112	ATP binding site [chemical binding]; other site
1205675002113	CAAX protease self-immunity; Region: Abi; pfam02517
1205675002114	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1205675002115	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1205675002116	active site
1205675002117	metal binding site [ion binding]; metal-binding site
1205675002118	hexamer interface [polypeptide binding]; other site
1205675002119	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
1205675002120	amidophosphoribosyltransferase; Provisional; Region: PRK07847
1205675002121	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1205675002122	active site
1205675002123	tetramer interface [polypeptide binding]; other site
1205675002124	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1205675002125	active site
1205675002126	phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878
1205675002127	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1205675002128	dimerization interface [polypeptide binding]; other site
1205675002129	putative ATP binding site [chemical binding]; other site
1205675002130	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
1205675002131	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1205675002132	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1205675002133	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1205675002134	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1205675002135	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675002136	catalytic residue [active]
1205675002137	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
1205675002138	heme-binding site [chemical binding]; other site
1205675002139	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
1205675002140	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1205675002141	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1205675002142	active site residue [active]
1205675002143	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1205675002144	active site residue [active]
1205675002145	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1205675002146	catalytic residues [active]
1205675002147	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1205675002148	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1205675002149	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1205675002150	DNA binding site [nucleotide binding]
1205675002151	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
1205675002152	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1205675002153	Coenzyme A binding pocket [chemical binding]; other site
1205675002154	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1205675002155	Coenzyme A binding pocket [chemical binding]; other site
1205675002156	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
1205675002157	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1205675002158	Walker A/P-loop; other site
1205675002159	ATP binding site [chemical binding]; other site
1205675002160	Q-loop/lid; other site
1205675002161	ABC transporter signature motif; other site
1205675002162	Walker B; other site
1205675002163	D-loop; other site
1205675002164	H-loop/switch region; other site
1205675002165	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1205675002166	PhoU domain; Region: PhoU; pfam01895
1205675002167	PhoU domain; Region: PhoU; pfam01895
1205675002168	cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350
1205675002169	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1205675002170	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1205675002171	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1205675002172	FMN binding site [chemical binding]; other site
1205675002173	active site
1205675002174	catalytic residues [active]
1205675002175	substrate binding site [chemical binding]; other site
1205675002176	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
1205675002177	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
1205675002178	homodimer interface [polypeptide binding]; other site
1205675002179	putative substrate binding pocket [chemical binding]; other site
1205675002180	diiron center [ion binding]; other site
1205675002181	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675002182	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
1205675002183	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1205675002184	dimerization interface [polypeptide binding]; other site
1205675002185	putative DNA binding site [nucleotide binding]; other site
1205675002186	putative Zn2+ binding site [ion binding]; other site
1205675002187	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1205675002188	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675002189	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1205675002190	TIGR04255 family protein; Region: sporadTIGR04255
1205675002191	PE family; Region: PE; pfam00934
1205675002192	PE family; Region: PE; pfam00934
1205675002193	PknH-like extracellular domain; Region: PknH_C; pfam14032
1205675002194	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
1205675002195	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861
1205675002196	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
1205675002197	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
1205675002198	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675002199	S-adenosylmethionine binding site [chemical binding]; other site
1205675002200	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
1205675002201	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675002202	putative substrate translocation pore; other site
1205675002203	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1205675002204	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1205675002205	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1205675002206	tetramer interface [polypeptide binding]; other site
1205675002207	TPP-binding site [chemical binding]; other site
1205675002208	heterodimer interface [polypeptide binding]; other site
1205675002209	phosphorylation loop region [posttranslational modification]
1205675002210	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1205675002211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1205675002212	active site
1205675002213	phosphorylation site [posttranslational modification]
1205675002214	intermolecular recognition site; other site
1205675002215	dimerization interface [polypeptide binding]; other site
1205675002216	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1205675002217	DNA binding residues [nucleotide binding]
1205675002218	dimerization interface [polypeptide binding]; other site
1205675002219	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1205675002220	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1205675002221	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1205675002222	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1205675002223	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1205675002224	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1205675002225	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1205675002226	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1205675002227	dimer interface [polypeptide binding]; other site
1205675002228	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675002229	catalytic residue [active]
1205675002230	multidrug resistance protein MdtH; Provisional; Region: PRK11646
1205675002231	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
1205675002232	short chain dehydrogenase; Provisional; Region: PRK05876
1205675002233	classical (c) SDRs; Region: SDR_c; cd05233
1205675002234	NAD(P) binding site [chemical binding]; other site
1205675002235	active site
1205675002236	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675002237	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1205675002238	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1205675002239	dimer interface [polypeptide binding]; other site
1205675002240	PYR/PP interface [polypeptide binding]; other site
1205675002241	TPP binding site [chemical binding]; other site
1205675002242	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1205675002243	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1205675002244	TPP-binding site [chemical binding]; other site
1205675002245	dimer interface [polypeptide binding]; other site
1205675002246	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1205675002247	putative hydrophobic ligand binding site [chemical binding]; other site
1205675002248	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1205675002249	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1205675002250	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1205675002251	putative hydrophobic ligand binding site [chemical binding]; other site
1205675002252	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1205675002253	putative hydrophobic ligand binding site [chemical binding]; other site
1205675002254	aminotransferase; Validated; Region: PRK07777
1205675002255	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1205675002256	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675002257	homodimer interface [polypeptide binding]; other site
1205675002258	catalytic residue [active]
1205675002259	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
1205675002260	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1205675002261	dimer interface [polypeptide binding]; other site
1205675002262	active site
1205675002263	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
1205675002264	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675002265	substrate binding site [chemical binding]; other site
1205675002266	oxyanion hole (OAH) forming residues; other site
1205675002267	trimer interface [polypeptide binding]; other site
1205675002268	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1205675002269	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1205675002270	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1205675002271	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1205675002272	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1205675002273	ATP binding site [chemical binding]; other site
1205675002274	putative Mg++ binding site [ion binding]; other site
1205675002275	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1205675002276	nucleotide binding region [chemical binding]; other site
1205675002277	ATP-binding site [chemical binding]; other site
1205675002278	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1205675002279	WYL domain; Region: WYL; pfam13280
1205675002280	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1205675002281	trimer interface [polypeptide binding]; other site
1205675002282	dimer interface [polypeptide binding]; other site
1205675002283	putative active site [active]
1205675002284	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1205675002285	MPT binding site; other site
1205675002286	trimer interface [polypeptide binding]; other site
1205675002287	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1205675002288	MoaE homodimer interface [polypeptide binding]; other site
1205675002289	MoaD interaction [polypeptide binding]; other site
1205675002290	active site residues [active]
1205675002291	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1205675002292	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1205675002293	MoaE interaction surface [polypeptide binding]; other site
1205675002294	MoeB interaction surface [polypeptide binding]; other site
1205675002295	thiocarboxylated glycine; other site
1205675002296	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1205675002297	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1205675002298	FeS/SAM binding site; other site
1205675002299	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1205675002300	hypothetical protein; Provisional; Region: PRK11770
1205675002301	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1205675002302	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1205675002303	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1205675002304	DNA-binding site [nucleotide binding]; DNA binding site
1205675002305	RNA-binding motif; other site
1205675002306	PE family; Region: PE; pfam00934
1205675002307	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675002308	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675002309	active site
1205675002310	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
1205675002311	H+ Antiporter protein; Region: 2A0121; TIGR00900
1205675002312	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
1205675002313	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675002314	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675002315	Protein of unknown function (DUF2530); Region: DUF2530; pfam10745
1205675002316	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1205675002317	MarR family; Region: MarR; pfam01047
1205675002318	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1205675002319	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1205675002320	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1205675002321	Protein of unknown function (DUF2537); Region: DUF2537; pfam10801
1205675002322	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
1205675002323	phosphoserine aminotransferase, putative; Region: serC_3; TIGR01366
1205675002324	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1205675002325	catalytic residue [active]
1205675002326	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1205675002327	Ferredoxin [Energy production and conversion]; Region: COG1146
1205675002328	4Fe-4S binding domain; Region: Fer4; pfam00037
1205675002329	ferredoxin-NADP+ reductase; Region: PLN02852
1205675002330	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1205675002331	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1205675002332	putative dimer interface [polypeptide binding]; other site
1205675002333	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1205675002334	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1205675002335	putative catalytic site [active]
1205675002336	putative phosphate binding site [ion binding]; other site
1205675002337	putative metal binding site [ion binding]; other site
1205675002338	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
1205675002339	dimer interface [polypeptide binding]; other site
1205675002340	Citrate synthase; Region: Citrate_synt; pfam00285
1205675002341	active site
1205675002342	citrylCoA binding site [chemical binding]; other site
1205675002343	oxalacetate/citrate binding site [chemical binding]; other site
1205675002344	coenzyme A binding site [chemical binding]; other site
1205675002345	catalytic triad [active]
1205675002346	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1205675002347	cyclase homology domain; Region: CHD; cd07302
1205675002348	nucleotidyl binding site; other site
1205675002349	metal binding site [ion binding]; metal-binding site
1205675002350	dimer interface [polypeptide binding]; other site
1205675002351	AAA ATPase domain; Region: AAA_16; pfam13191
1205675002352	Predicted ATPase [General function prediction only]; Region: COG3903
1205675002353	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1205675002354	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1205675002355	DNA binding residues [nucleotide binding]
1205675002356	dimerization interface [polypeptide binding]; other site
1205675002357	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1205675002358	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1205675002359	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675002360	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1205675002361	AAA ATPase domain; Region: AAA_16; pfam13191
1205675002362	Predicted ATPase [General function prediction only]; Region: COG3903
1205675002363	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1205675002364	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1205675002365	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1205675002366	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1205675002367	dimer interface [polypeptide binding]; other site
1205675002368	active site
1205675002369	citrylCoA binding site [chemical binding]; other site
1205675002370	NADH binding [chemical binding]; other site
1205675002371	cationic pore residues; other site
1205675002372	oxalacetate/citrate binding site [chemical binding]; other site
1205675002373	coenzyme A binding site [chemical binding]; other site
1205675002374	catalytic triad [active]
1205675002375	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1205675002376	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1205675002377	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
1205675002378	BON domain; Region: BON; pfam04972
1205675002379	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1205675002380	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1205675002381	ligand binding site [chemical binding]; other site
1205675002382	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
1205675002383	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1205675002384	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1205675002385	dimerization interface [polypeptide binding]; other site
1205675002386	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1205675002387	dimer interface [polypeptide binding]; other site
1205675002388	phosphorylation site [posttranslational modification]
1205675002389	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1205675002390	Mg2+ binding site [ion binding]; other site
1205675002391	G-X-G motif; other site
1205675002392	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1205675002393	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1205675002394	active site
1205675002395	phosphorylation site [posttranslational modification]
1205675002396	intermolecular recognition site; other site
1205675002397	dimerization interface [polypeptide binding]; other site
1205675002398	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1205675002399	DNA binding site [nucleotide binding]
1205675002400	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
1205675002401	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825
1205675002402	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1205675002403	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675002404	substrate binding site [chemical binding]; other site
1205675002405	oxyanion hole (OAH) forming residues; other site
1205675002406	trimer interface [polypeptide binding]; other site
1205675002407	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1205675002408	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1205675002409	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1205675002410	Beta-lactamase; Region: Beta-lactamase; pfam00144
1205675002411	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
1205675002412	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1205675002413	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1205675002414	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1205675002415	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675002416	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1205675002417	Integrase core domain; Region: rve; pfam00665
1205675002418	Integrase core domain; Region: rve_3; cl15866
1205675002419	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675002420	transposase; Provisional; Region: PRK06526
1205675002421	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675002422	Walker A motif; other site
1205675002423	ATP binding site [chemical binding]; other site
1205675002424	Walker B motif; other site
1205675002425	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
1205675002426	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1205675002427	hydrophobic ligand binding site; other site
1205675002428	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1205675002429	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1205675002430	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1205675002431	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1205675002432	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
1205675002433	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
1205675002434	acetyl-CoA acetyltransferase; Provisional; Region: PRK06289
1205675002435	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1205675002436	active site
1205675002437	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675002438	PPE family; Region: PPE; pfam00823
1205675002439	PE family; Region: PE; pfam00934
1205675002440	BCCT family transporter; Region: BCCT; pfam02028
1205675002441	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
1205675002442	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1205675002443	Coenzyme A binding pocket [chemical binding]; other site
1205675002444	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1205675002445	MULE transposase domain; Region: MULE; pfam10551
1205675002446	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
1205675002447	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
1205675002448	catalytic residues [active]
1205675002449	catalytic nucleophile [active]
1205675002450	Probable transposase; Region: OrfB_IS605; pfam01385
1205675002451	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1205675002452	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1205675002453	putative active site pocket [active]
1205675002454	dimerization interface [polypeptide binding]; other site
1205675002455	putative catalytic residue [active]
1205675002456	Protein of unknown function (DUF867); Region: DUF867; cl01713
1205675002457	manganese transport protein MntH; Reviewed; Region: PRK00701
1205675002458	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1205675002459	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1205675002460	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1205675002461	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
1205675002462	short chain dehydrogenase; Provisional; Region: PRK07814
1205675002463	classical (c) SDRs; Region: SDR_c; cd05233
1205675002464	NAD(P) binding site [chemical binding]; other site
1205675002465	active site
1205675002466	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
1205675002467	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
1205675002468	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675002469	dimer interface [polypeptide binding]; other site
1205675002470	conserved gate region; other site
1205675002471	putative PBP binding loops; other site
1205675002472	ABC-ATPase subunit interface; other site
1205675002473	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1205675002474	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675002475	dimer interface [polypeptide binding]; other site
1205675002476	conserved gate region; other site
1205675002477	putative PBP binding loops; other site
1205675002478	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1205675002479	ABC-ATPase subunit interface; other site
1205675002480	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1205675002481	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1205675002482	active site
1205675002483	ATP binding site [chemical binding]; other site
1205675002484	substrate binding site [chemical binding]; other site
1205675002485	activation loop (A-loop); other site
1205675002486	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1205675002487	NHL repeat; Region: NHL; pfam01436
1205675002488	NHL repeat; Region: NHL; pfam01436
1205675002489	NHL repeat; Region: NHL; pfam01436
1205675002490	NHL repeat; Region: NHL; pfam01436
1205675002491	NHL repeat; Region: NHL; pfam01436
1205675002492	PBP superfamily domain; Region: PBP_like_2; cl17296
1205675002493	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14271
1205675002494	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1205675002495	Walker A/P-loop; other site
1205675002496	ATP binding site [chemical binding]; other site
1205675002497	Q-loop/lid; other site
1205675002498	ABC transporter signature motif; other site
1205675002499	Walker B; other site
1205675002500	D-loop; other site
1205675002501	H-loop/switch region; other site
1205675002502	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
1205675002503	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
1205675002504	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675002505	dimer interface [polypeptide binding]; other site
1205675002506	conserved gate region; other site
1205675002507	putative PBP binding loops; other site
1205675002508	ABC-ATPase subunit interface; other site
1205675002509	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1205675002510	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675002511	dimer interface [polypeptide binding]; other site
1205675002512	conserved gate region; other site
1205675002513	putative PBP binding loops; other site
1205675002514	ABC-ATPase subunit interface; other site
1205675002515	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1205675002516	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1205675002517	putative DNA binding site [nucleotide binding]; other site
1205675002518	putative homodimer interface [polypeptide binding]; other site
1205675002519	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
1205675002520	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
1205675002521	nucleotide binding site [chemical binding]; other site
1205675002522	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
1205675002523	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1205675002524	active site
1205675002525	DNA binding site [nucleotide binding]
1205675002526	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1205675002527	DNA binding site [nucleotide binding]
1205675002528	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1205675002529	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1205675002530	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1205675002531	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1205675002532	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1205675002533	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1205675002534	anti sigma factor interaction site; other site
1205675002535	regulatory phosphorylation site [posttranslational modification]; other site
1205675002536	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1205675002537	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1205675002538	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
1205675002539	homodimer interface [polypeptide binding]; other site
1205675002540	active site
1205675002541	SAM binding site [chemical binding]; other site
1205675002542	PE family; Region: PE; pfam00934
1205675002543	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1205675002544	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
1205675002545	putative DNA binding site [nucleotide binding]; other site
1205675002546	catalytic residue [active]
1205675002547	putative H2TH interface [polypeptide binding]; other site
1205675002548	putative catalytic residues [active]
1205675002549	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1205675002550	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1205675002551	short chain dehydrogenase; Provisional; Region: PRK08251
1205675002552	classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350
1205675002553	putative NAD(P) binding site [chemical binding]; other site
1205675002554	active site
1205675002555	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1205675002556	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1205675002557	active site
1205675002558	dimer interface [polypeptide binding]; other site
1205675002559	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1205675002560	dimer interface [polypeptide binding]; other site
1205675002561	active site
1205675002562	Predicted esterase [General function prediction only]; Region: COG0627
1205675002563	hypothetical protein; Provisional; Region: PRK07857
1205675002564	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1205675002565	Part of AAA domain; Region: AAA_19; pfam13245
1205675002566	Family description; Region: UvrD_C_2; pfam13538
1205675002567	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1205675002568	Peptidase family M23; Region: Peptidase_M23; pfam01551
1205675002569	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1205675002570	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1205675002571	CoA-ligase; Region: Ligase_CoA; pfam00549
1205675002572	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1205675002573	CoA binding domain; Region: CoA_binding; smart00881
1205675002574	CoA-ligase; Region: Ligase_CoA; pfam00549
1205675002575	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1205675002576	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1205675002577	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1205675002578	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1205675002579	active site
1205675002580	substrate binding site [chemical binding]; other site
1205675002581	cosubstrate binding site; other site
1205675002582	catalytic site [active]
1205675002583	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1205675002584	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1205675002585	purine monophosphate binding site [chemical binding]; other site
1205675002586	dimer interface [polypeptide binding]; other site
1205675002587	putative catalytic residues [active]
1205675002588	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1205675002589	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1205675002590	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
1205675002591	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1205675002592	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
1205675002593	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1205675002594	metal ion-dependent adhesion site (MIDAS); other site
1205675002595	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
1205675002596	homotetrameric interface [polypeptide binding]; other site
1205675002597	putative active site [active]
1205675002598	metal binding site [ion binding]; metal-binding site
1205675002599	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
1205675002600	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1205675002601	Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151
1205675002602	putative homodimer interface [polypeptide binding]; other site
1205675002603	putative homotetramer interface [polypeptide binding]; other site
1205675002604	allosteric switch controlling residues; other site
1205675002605	putative metal binding site [ion binding]; other site
1205675002606	putative homodimer-homodimer interface [polypeptide binding]; other site
1205675002607	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
1205675002608	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1205675002609	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1205675002610	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1205675002611	enoyl-CoA hydratase; Provisional; Region: PRK07827
1205675002612	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675002613	substrate binding site [chemical binding]; other site
1205675002614	oxyanion hole (OAH) forming residues; other site
1205675002615	trimer interface [polypeptide binding]; other site
1205675002616	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675002617	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1205675002618	active site
1205675002619	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1205675002620	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1205675002621	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1205675002622	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1205675002623	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1205675002624	carboxyltransferase (CT) interaction site; other site
1205675002625	biotinylation site [posttranslational modification]; other site
1205675002626	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1205675002627	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1205675002628	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675002629	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675002630	active site
1205675002631	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
1205675002632	PE family; Region: PE; pfam00934
1205675002633	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1205675002634	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1205675002635	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1205675002636	PE family; Region: PE; pfam00934
1205675002637	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1205675002638	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1205675002639	active site
1205675002640	phosphorylation site [posttranslational modification]
1205675002641	intermolecular recognition site; other site
1205675002642	dimerization interface [polypeptide binding]; other site
1205675002643	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1205675002644	DNA binding site [nucleotide binding]
1205675002645	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1205675002646	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1205675002647	dimerization interface [polypeptide binding]; other site
1205675002648	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1205675002649	dimer interface [polypeptide binding]; other site
1205675002650	phosphorylation site [posttranslational modification]
1205675002651	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1205675002652	ATP binding site [chemical binding]; other site
1205675002653	Mg2+ binding site [ion binding]; other site
1205675002654	G-X-G motif; other site
1205675002655	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1205675002656	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1205675002657	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1205675002658	MPT binding site; other site
1205675002659	trimer interface [polypeptide binding]; other site
1205675002660	Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741
1205675002661	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1205675002662	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1205675002663	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1205675002664	Walker A/P-loop; other site
1205675002665	ATP binding site [chemical binding]; other site
1205675002666	Q-loop/lid; other site
1205675002667	ABC transporter signature motif; other site
1205675002668	Walker B; other site
1205675002669	D-loop; other site
1205675002670	H-loop/switch region; other site
1205675002671	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1205675002672	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1205675002673	FtsX-like permease family; Region: FtsX; pfam02687
1205675002674	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1205675002675	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1205675002676	FtsX-like permease family; Region: FtsX; pfam02687
1205675002677	Predicted secreted hydrolase [General function prediction only]; Region: COG5621
1205675002678	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1205675002679	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1205675002680	substrate binding pocket [chemical binding]; other site
1205675002681	chain length determination region; other site
1205675002682	substrate-Mg2+ binding site; other site
1205675002683	catalytic residues [active]
1205675002684	aspartate-rich region 1; other site
1205675002685	active site lid residues [active]
1205675002686	aspartate-rich region 2; other site
1205675002687	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1205675002688	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2331
1205675002689	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
1205675002690	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1205675002691	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
1205675002692	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1205675002693	active site
1205675002694	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1205675002695	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1205675002696	dimer interface [polypeptide binding]; other site
1205675002697	putative functional site; other site
1205675002698	putative MPT binding site; other site
1205675002699	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1205675002700	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1205675002701	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1205675002702	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1205675002703	ligand binding site [chemical binding]; other site
1205675002704	flexible hinge region; other site
1205675002705	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1205675002706	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1205675002707	Coenzyme A binding pocket [chemical binding]; other site
1205675002708	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
1205675002709	arginine deiminase; Provisional; Region: PRK01388
1205675002710	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
1205675002711	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1205675002712	Predicted methyltransferases [General function prediction only]; Region: COG0313
1205675002713	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1205675002714	putative SAM binding site [chemical binding]; other site
1205675002715	putative homodimer interface [polypeptide binding]; other site
1205675002716	aminodeoxychorismate synthase component I; Provisional; Region: PRK05877
1205675002717	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
1205675002718	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
1205675002719	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1205675002720	active site
1205675002721	HIGH motif; other site
1205675002722	KMSKS motif; other site
1205675002723	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1205675002724	tRNA binding surface [nucleotide binding]; other site
1205675002725	anticodon binding site; other site
1205675002726	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1205675002727	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1205675002728	active site
1205675002729	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
1205675002730	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1205675002731	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1205675002732	G5 domain; Region: G5; pfam07501
1205675002733	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1205675002734	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1205675002735	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675002736	S-adenosylmethionine binding site [chemical binding]; other site
1205675002737	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
1205675002738	Increased loss of mitochondrial DNA protein 1; Region: Ilm1; pfam10311
1205675002739	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1205675002740	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
1205675002741	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675002742	acyl-activating enzyme (AAE) consensus motif; other site
1205675002743	AMP binding site [chemical binding]; other site
1205675002744	active site
1205675002745	CoA binding site [chemical binding]; other site
1205675002746	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1205675002747	putative active site [active]
1205675002748	catalytic residue [active]
1205675002749	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1205675002750	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
1205675002751	5S rRNA interface [nucleotide binding]; other site
1205675002752	CTC domain interface [polypeptide binding]; other site
1205675002753	L16 interface [polypeptide binding]; other site
1205675002754	Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738
1205675002755	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1205675002756	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
1205675002757	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1205675002758	active site
1205675002759	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
1205675002760	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1205675002761	Substrate binding site; other site
1205675002762	Mg++ binding site; other site
1205675002763	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1205675002764	active site
1205675002765	substrate binding site [chemical binding]; other site
1205675002766	CoA binding site [chemical binding]; other site
1205675002767	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675002768	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675002769	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1205675002770	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1205675002771	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1205675002772	ATP binding site [chemical binding]; other site
1205675002773	putative Mg++ binding site [ion binding]; other site
1205675002774	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1205675002775	nucleotide binding region [chemical binding]; other site
1205675002776	ATP-binding site [chemical binding]; other site
1205675002777	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1205675002778	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
1205675002779	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1205675002780	homodimer interface [polypeptide binding]; other site
1205675002781	metal binding site [ion binding]; metal-binding site
1205675002782	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
1205675002783	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
1205675002784	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1205675002785	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1205675002786	enolase; Provisional; Region: eno; PRK00077
1205675002787	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1205675002788	dimer interface [polypeptide binding]; other site
1205675002789	metal binding site [ion binding]; metal-binding site
1205675002790	substrate binding pocket [chemical binding]; other site
1205675002791	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1205675002792	Septum formation initiator; Region: DivIC; pfam04977
1205675002793	Uncharacterized conserved protein [Function unknown]; Region: COG1507
1205675002794	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1205675002795	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1205675002796	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
1205675002797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1205675002798	active site
1205675002799	phosphorylation site [posttranslational modification]
1205675002800	intermolecular recognition site; other site
1205675002801	dimerization interface [polypeptide binding]; other site
1205675002802	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1205675002803	DNA binding site [nucleotide binding]
1205675002804	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1205675002805	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1205675002806	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1205675002807	Ligand Binding Site [chemical binding]; other site
1205675002808	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1205675002809	dimer interface [polypeptide binding]; other site
1205675002810	phosphorylation site [posttranslational modification]
1205675002811	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1205675002812	ATP binding site [chemical binding]; other site
1205675002813	Mg2+ binding site [ion binding]; other site
1205675002814	G-X-G motif; other site
1205675002815	K+-transporting ATPase, KdpA; Region: kdpA; TIGR00680
1205675002816	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1205675002817	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1205675002818	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1205675002819	K+-transporting ATPase, c chain; Region: KdpC; cl00944
1205675002820	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1205675002821	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1205675002822	dimer interface [polypeptide binding]; other site
1205675002823	phosphorylation site [posttranslational modification]
1205675002824	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1205675002825	ATP binding site [chemical binding]; other site
1205675002826	Mg2+ binding site [ion binding]; other site
1205675002827	G-X-G motif; other site
1205675002828	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1205675002829	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1205675002830	active site
1205675002831	phosphorylation site [posttranslational modification]
1205675002832	intermolecular recognition site; other site
1205675002833	dimerization interface [polypeptide binding]; other site
1205675002834	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1205675002835	DNA binding site [nucleotide binding]
1205675002836	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
1205675002837	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1205675002838	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme
1205675002839	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme
1205675002840	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1205675002841	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1205675002842	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675002843	PPE family; Region: PPE; pfam00823
1205675002844	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675002845	PE family; Region: PE; pfam00934
1205675002846	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675002847	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1205675002848	Transposase; Region: HTH_Tnp_1; pfam01527
1205675002849	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1205675002850	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
1205675002851	Protein of unknown function (DUF499); Region: DUF499; pfam04465
1205675002852	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
1205675002853	transposase; Provisional; Region: PRK06526
1205675002854	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675002855	Walker A motif; other site
1205675002856	ATP binding site [chemical binding]; other site
1205675002857	Walker B motif; other site
1205675002858	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675002859	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675002860	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1205675002861	Integrase core domain; Region: rve; pfam00665
1205675002862	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
1205675002863	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
1205675002864	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
1205675002865	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1205675002866	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1205675002867	nucleotide binding region [chemical binding]; other site
1205675002868	ATP-binding site [chemical binding]; other site
1205675002869	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1205675002870	ATP binding site [chemical binding]; other site
1205675002871	putative Mg++ binding site [ion binding]; other site
1205675002872	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
1205675002873	AAA domain; Region: AAA_21; pfam13304
1205675002874	Family description; Region: UvrD_C_2; pfam13538
1205675002875	Predicted transcriptional regulator [Transcription]; Region: COG5340
1205675002876	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1205675002877	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1205675002878	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1205675002879	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1205675002880	Fic/DOC family; Region: Fic; pfam02661
1205675002881	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1205675002882	Domain of unknown function (DUF427); Region: DUF427; cl00998
1205675002883	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
1205675002884	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1205675002885	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1205675002886	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
1205675002887	dimer interface [polypeptide binding]; other site
1205675002888	acyl-activating enzyme (AAE) consensus motif; other site
1205675002889	putative active site [active]
1205675002890	AMP binding site [chemical binding]; other site
1205675002891	putative CoA binding site [chemical binding]; other site
1205675002892	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
1205675002893	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
1205675002894	hydrophobic ligand binding site; other site
1205675002895	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1205675002896	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1205675002897	putative active site [active]
1205675002898	putative dimer interface [polypeptide binding]; other site
1205675002899	Patatin-like phospholipase; Region: Patatin; pfam01734
1205675002900	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1205675002901	nucleophile elbow; other site
1205675002902	hypothetical protein; Provisional; Region: PRK10279
1205675002903	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
1205675002904	active site
1205675002905	nucleophile elbow; other site
1205675002906	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
1205675002907	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1205675002908	active site residue [active]
1205675002909	PE family; Region: PE; pfam00934
1205675002910	PE family; Region: PE; pfam00934
1205675002911	Predicted membrane protein [Function unknown]; Region: COG4425
1205675002912	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
1205675002913	enoyl-CoA hydratase; Provisional; Region: PRK05862
1205675002914	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675002915	substrate binding site [chemical binding]; other site
1205675002916	oxyanion hole (OAH) forming residues; other site
1205675002917	trimer interface [polypeptide binding]; other site
1205675002918	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1205675002919	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675002920	substrate binding site [chemical binding]; other site
1205675002921	oxyanion hole (OAH) forming residues; other site
1205675002922	trimer interface [polypeptide binding]; other site
1205675002923	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1205675002924	Predicted membrane protein [Function unknown]; Region: COG4760
1205675002925	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1205675002926	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
1205675002927	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1205675002928	dimer interface [polypeptide binding]; other site
1205675002929	active site
1205675002930	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
1205675002931	active site
1205675002932	catalytic triad [active]
1205675002933	oxyanion hole [active]
1205675002934	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1205675002935	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1205675002936	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
1205675002937	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1205675002938	dimer interface [polypeptide binding]; other site
1205675002939	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675002940	catalytic residue [active]
1205675002941	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
1205675002942	RDD family; Region: RDD; pfam06271
1205675002943	cystathionine gamma-synthase; Provisional; Region: PRK07811
1205675002944	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1205675002945	homodimer interface [polypeptide binding]; other site
1205675002946	substrate-cofactor binding pocket; other site
1205675002947	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675002948	catalytic residue [active]
1205675002949	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1205675002950	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1205675002951	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1205675002952	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
1205675002953	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
1205675002954	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
1205675002955	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
1205675002956	catalytic residues [active]
1205675002957	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
1205675002958	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1205675002959	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1205675002960	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1205675002961	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1205675002962	catalytic residue [active]
1205675002963	putative FPP diphosphate  binding site; other site
1205675002964	putative FPP binding hydrophobic cleft; other site
1205675002965	dimer interface [polypeptide binding]; other site
1205675002966	putative IPP diphosphate binding site; other site
1205675002967	PE family; Region: PE; pfam00934
1205675002968	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1205675002969	putative IPP diphosphate binding site; other site
1205675002970	PE family; Region: PE; pfam00934
1205675002971	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme
1205675002972	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme
1205675002973	PE family; Region: PE; pfam00934
1205675002974	pantothenate kinase; Provisional; Region: PRK05439
1205675002975	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1205675002976	ATP-binding site [chemical binding]; other site
1205675002977	CoA-binding site [chemical binding]; other site
1205675002978	Mg2+-binding site [ion binding]; other site
1205675002979	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1205675002980	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1205675002981	dimer interface [polypeptide binding]; other site
1205675002982	active site
1205675002983	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1205675002984	folate binding site [chemical binding]; other site
1205675002985	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1205675002986	dinuclear metal binding motif [ion binding]; other site
1205675002987	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1205675002988	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1205675002989	putative active site [active]
1205675002990	PhoH-like protein; Region: PhoH; pfam02562
1205675002991	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1205675002992	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1205675002993	NodB motif; other site
1205675002994	active site
1205675002995	catalytic site [active]
1205675002996	metal binding site [ion binding]; metal-binding site
1205675002997	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1205675002998	Class II fumarases; Region: Fumarase_classII; cd01362
1205675002999	active site
1205675003000	tetramer interface [polypeptide binding]; other site
1205675003001	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1205675003002	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1205675003003	putative active site [active]
1205675003004	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
1205675003005	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1205675003006	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1205675003007	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1205675003008	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1205675003009	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1205675003010	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1205675003011	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1205675003012	3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241
1205675003013	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
1205675003014	putative NAD(P) binding site [chemical binding]; other site
1205675003015	active site
1205675003016	putative substrate binding site [chemical binding]; other site
1205675003017	exodeoxyribonuclease VII, small subunit; Region: xseB; TIGR01280
1205675003018	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
1205675003019	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1205675003020	generic binding surface II; other site
1205675003021	generic binding surface I; other site
1205675003022	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1205675003023	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1205675003024	GTP-binding protein YchF; Reviewed; Region: PRK09601
1205675003025	YchF GTPase; Region: YchF; cd01900
1205675003026	G1 box; other site
1205675003027	GTP/Mg2+ binding site [chemical binding]; other site
1205675003028	Switch I region; other site
1205675003029	G2 box; other site
1205675003030	Switch II region; other site
1205675003031	G3 box; other site
1205675003032	G4 box; other site
1205675003033	G5 box; other site
1205675003034	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1205675003035	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
1205675003036	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487
1205675003037	putative active site [active]
1205675003038	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
1205675003039	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1205675003040	cyclase homology domain; Region: CHD; cd07302
1205675003041	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1205675003042	cyclase homology domain; Region: CHD; cd07302
1205675003043	nucleotidyl binding site; other site
1205675003044	metal binding site [ion binding]; metal-binding site
1205675003045	dimer interface [polypeptide binding]; other site
1205675003046	glucose-6-phosphate 1-dehydrogenase; Region: zwf; TIGR00871
1205675003047	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1205675003048	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1205675003049	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1205675003050	6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872
1205675003051	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1205675003052	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675003053	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1205675003054	pyruvate phosphate dikinase; Provisional; Region: PRK05878
1205675003055	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1205675003056	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700
1205675003057	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675003058	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675003059	active site
1205675003060	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1205675003061	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1205675003062	non-specific DNA binding site [nucleotide binding]; other site
1205675003063	salt bridge; other site
1205675003064	sequence-specific DNA binding site [nucleotide binding]; other site
1205675003065	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1205675003066	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1205675003067	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1205675003068	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1205675003069	citrate synthase; Provisional; Region: PRK14033
1205675003070	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
1205675003071	oxalacetate binding site [chemical binding]; other site
1205675003072	citrylCoA binding site [chemical binding]; other site
1205675003073	coenzyme A binding site [chemical binding]; other site
1205675003074	catalytic triad [active]
1205675003075	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
1205675003076	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1205675003077	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1205675003078	THF binding site; other site
1205675003079	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1205675003080	substrate binding site [chemical binding]; other site
1205675003081	THF binding site; other site
1205675003082	zinc-binding site [ion binding]; other site
1205675003083	PPE family; Region: PPE; pfam00823
1205675003084	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675003085	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675003086	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675003087	substrate binding site [chemical binding]; other site
1205675003088	oxyanion hole (OAH) forming residues; other site
1205675003089	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1205675003090	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
1205675003091	CAAX protease self-immunity; Region: Abi; pfam02517
1205675003092	enoyl-CoA hydratase; Provisional; Region: PRK06688
1205675003093	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
1205675003094	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675003095	trimer interface [polypeptide binding]; other site
1205675003096	enoyl-CoA hydratase; Provisional; Region: PRK06688
1205675003097	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675003098	substrate binding site [chemical binding]; other site
1205675003099	oxyanion hole (OAH) forming residues; other site
1205675003100	trimer interface [polypeptide binding]; other site
1205675003101	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1205675003102	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1205675003103	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
1205675003104	NAD binding site [chemical binding]; other site
1205675003105	homodimer interface [polypeptide binding]; other site
1205675003106	homotetramer interface [polypeptide binding]; other site
1205675003107	active site
1205675003108	MMPL family; Region: MMPL; pfam03176
1205675003109	MMPL family; Region: MMPL; pfam03176
1205675003110	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675003111	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675003112	active site
1205675003113	NAD-dependent deacetylase; Provisional; Region: PRK00481
1205675003114	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
1205675003115	NAD+ binding site [chemical binding]; other site
1205675003116	substrate binding site [chemical binding]; other site
1205675003117	Zn binding site [ion binding]; other site
1205675003118	Predicted transcriptional regulators [Transcription]; Region: COG1725
1205675003119	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1205675003120	DNA-binding site [nucleotide binding]; DNA binding site
1205675003121	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675003122	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1205675003123	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
1205675003124	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1205675003125	uncharacterized HhH-GPD family protein; Region: TIGR03252
1205675003126	minor groove reading motif; other site
1205675003127	helix-hairpin-helix signature motif; other site
1205675003128	mannosyltransferase; Provisional; Region: pimE; PRK13375
1205675003129	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
1205675003130	aromatic arch; other site
1205675003131	DCoH dimer interaction site [polypeptide binding]; other site
1205675003132	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1205675003133	DCoH tetramer interaction site [polypeptide binding]; other site
1205675003134	substrate binding site [chemical binding]; other site
1205675003135	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1205675003136	active site
1205675003137	8-oxo-dGMP binding site [chemical binding]; other site
1205675003138	nudix motif; other site
1205675003139	metal binding site [ion binding]; metal-binding site
1205675003140	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1205675003141	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1205675003142	[4Fe-4S] binding site [ion binding]; other site
1205675003143	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1205675003144	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1205675003145	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1205675003146	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1205675003147	molybdopterin cofactor binding site; other site
1205675003148	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1205675003149	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
1205675003150	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1205675003151	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1205675003152	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1205675003153	G1 box; other site
1205675003154	putative GEF interaction site [polypeptide binding]; other site
1205675003155	GTP/Mg2+ binding site [chemical binding]; other site
1205675003156	Switch I region; other site
1205675003157	G2 box; other site
1205675003158	G3 box; other site
1205675003159	Switch II region; other site
1205675003160	G4 box; other site
1205675003161	G5 box; other site
1205675003162	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1205675003163	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1205675003164	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1205675003165	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1205675003166	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1205675003167	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675003168	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675003169	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675003170	PPE family; Region: PPE; pfam00823
1205675003171	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675003172	PE family; Region: PE; pfam00934
1205675003173	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
1205675003174	PE family; Region: PE; pfam00934
1205675003175	FO synthase; Reviewed; Region: fbiC; PRK09234
1205675003176	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1205675003177	FeS/SAM binding site; other site
1205675003178	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1205675003179	FeS/SAM binding site; other site
1205675003180	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1205675003181	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
1205675003182	active site
1205675003183	FMN binding site [chemical binding]; other site
1205675003184	2,4-decadienoyl-CoA binding site; other site
1205675003185	catalytic residue [active]
1205675003186	4Fe-4S cluster binding site [ion binding]; other site
1205675003187	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1205675003188	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1205675003189	Predicted transcriptional regulators [Transcription]; Region: COG1695
1205675003190	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1205675003191	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1205675003192	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
1205675003193	4Fe-4S binding domain; Region: Fer4; pfam00037
1205675003194	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
1205675003195	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1205675003196	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675003197	homodimer interface [polypeptide binding]; other site
1205675003198	catalytic residue [active]
1205675003199	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1205675003200	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1205675003201	ATP binding site [chemical binding]; other site
1205675003202	putative Mg++ binding site [ion binding]; other site
1205675003203	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1205675003204	ATP-binding site [chemical binding]; other site
1205675003205	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1205675003206	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675003207	active site
1205675003208	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1205675003209	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1205675003210	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675003211	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1205675003212	Enoylreductase; Region: PKS_ER; smart00829
1205675003213	NAD(P) binding site [chemical binding]; other site
1205675003214	KR domain; Region: KR; pfam08659
1205675003215	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1205675003216	putative NADP binding site [chemical binding]; other site
1205675003217	active site
1205675003218	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675003219	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1205675003220	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1205675003221	PE-PPE domain; Region: PE-PPE; pfam08237
1205675003222	acyl-CoA synthetase; Validated; Region: PRK05850
1205675003223	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1205675003224	acyl-activating enzyme (AAE) consensus motif; other site
1205675003225	active site
1205675003226	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1205675003227	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1205675003228	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
1205675003229	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
1205675003230	Glutamate binding site [chemical binding]; other site
1205675003231	NAD binding site [chemical binding]; other site
1205675003232	catalytic residues [active]
1205675003233	Proline dehydrogenase; Region: Pro_dh; pfam01619
1205675003234	RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635
1205675003235	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1205675003236	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1205675003237	DNA binding residues [nucleotide binding]
1205675003238	haloalkane dehalogenase; Provisional; Region: PRK03204
1205675003239	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1205675003240	catalytic site [active]
1205675003241	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675003242	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
1205675003243	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1205675003244	PGAP1-like protein; Region: PGAP1; pfam07819
1205675003245	acyl-CoA synthetase; Validated; Region: PRK07787
1205675003246	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675003247	acyl-activating enzyme (AAE) consensus motif; other site
1205675003248	AMP binding site [chemical binding]; other site
1205675003249	active site
1205675003250	CoA binding site [chemical binding]; other site
1205675003251	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1205675003252	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1205675003253	PE family; Region: PE; pfam00934
1205675003254	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675003255	PPE family; Region: PPE; pfam00823
1205675003256	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675003257	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1205675003258	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1205675003259	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1205675003260	MULE transposase domain; Region: MULE; pfam10551
1205675003261	metabolite-proton symporter; Region: 2A0106; TIGR00883
1205675003262	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675003263	putative substrate translocation pore; other site
1205675003264	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
1205675003265	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
1205675003266	putative trimer interface [polypeptide binding]; other site
1205675003267	putative CoA binding site [chemical binding]; other site
1205675003268	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
1205675003269	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
1205675003270	metal binding site [ion binding]; metal-binding site
1205675003271	putative dimer interface [polypeptide binding]; other site
1205675003272	TIGR00730 family protein; Region: TIGR00730
1205675003273	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
1205675003274	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
1205675003275	acyl-activating enzyme (AAE) consensus motif; other site
1205675003276	putative AMP binding site [chemical binding]; other site
1205675003277	putative active site [active]
1205675003278	putative CoA binding site [chemical binding]; other site
1205675003279	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1205675003280	dihydropteroate synthase; Region: DHPS; TIGR01496
1205675003281	substrate binding pocket [chemical binding]; other site
1205675003282	dimer interface [polypeptide binding]; other site
1205675003283	inhibitor binding site; inhibition site
1205675003284	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
1205675003285	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1205675003286	DivIVA domain; Region: DivI1A_domain; TIGR03544
1205675003287	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
1205675003288	Protein of unknown function (DUF3117); Region: DUF3117; pfam11314
1205675003289	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
1205675003290	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1205675003291	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
1205675003292	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1205675003293	ligand binding site; other site
1205675003294	oligomer interface; other site
1205675003295	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1205675003296	dimer interface [polypeptide binding]; other site
1205675003297	N-terminal domain interface [polypeptide binding]; other site
1205675003298	sulfate 1 binding site; other site
1205675003299	PE family; Region: PE; pfam00934
1205675003300	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
1205675003301	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1205675003302	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
1205675003303	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1205675003304	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
1205675003305	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1205675003306	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1205675003307	Walker A/P-loop; other site
1205675003308	ATP binding site [chemical binding]; other site
1205675003309	Q-loop/lid; other site
1205675003310	ABC transporter signature motif; other site
1205675003311	Walker B; other site
1205675003312	D-loop; other site
1205675003313	H-loop/switch region; other site
1205675003314	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1205675003315	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675003316	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1205675003317	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675003318	S-adenosylmethionine binding site [chemical binding]; other site
1205675003319	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
1205675003320	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1205675003321	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1205675003322	DNA binding residues [nucleotide binding]
1205675003323	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1205675003324	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1205675003325	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1205675003326	protein binding site [polypeptide binding]; other site
1205675003327	sec-independent translocase; Provisional; Region: PRK03100
1205675003328	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1205675003329	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1205675003330	active site
1205675003331	motif I; other site
1205675003332	motif II; other site
1205675003333	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1205675003334	Predicted membrane protein [Function unknown]; Region: COG3428
1205675003335	Bacterial PH domain; Region: DUF304; pfam03703
1205675003336	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1205675003337	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
1205675003338	Domain of unknown function DUF59; Region: DUF59; cl00941
1205675003339	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1205675003340	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1205675003341	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
1205675003342	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1205675003343	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1205675003344	catalytic residue [active]
1205675003345	Predicted membrane protein [Function unknown]; Region: COG4420
1205675003346	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1205675003347	MgtE intracellular N domain; Region: MgtE_N; smart00924
1205675003348	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1205675003349	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
1205675003350	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1205675003351	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1205675003352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675003353	dimer interface [polypeptide binding]; other site
1205675003354	conserved gate region; other site
1205675003355	putative PBP binding loops; other site
1205675003356	ABC-ATPase subunit interface; other site
1205675003357	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1205675003358	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675003359	dimer interface [polypeptide binding]; other site
1205675003360	conserved gate region; other site
1205675003361	ABC-ATPase subunit interface; other site
1205675003362	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1205675003363	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1205675003364	Walker A/P-loop; other site
1205675003365	ATP binding site [chemical binding]; other site
1205675003366	Q-loop/lid; other site
1205675003367	ABC transporter signature motif; other site
1205675003368	Walker B; other site
1205675003369	D-loop; other site
1205675003370	H-loop/switch region; other site
1205675003371	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1205675003372	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
1205675003373	oligomer interface [polypeptide binding]; other site
1205675003374	metal binding site [ion binding]; metal-binding site
1205675003375	metal binding site [ion binding]; metal-binding site
1205675003376	putative Cl binding site [ion binding]; other site
1205675003377	basic sphincter; other site
1205675003378	hydrophobic gate; other site
1205675003379	periplasmic entrance; other site
1205675003380	malate dehydrogenase; Provisional; Region: PRK05442
1205675003381	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
1205675003382	NAD(P) binding site [chemical binding]; other site
1205675003383	dimer interface [polypeptide binding]; other site
1205675003384	malate binding site [chemical binding]; other site
1205675003385	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1205675003386	PE family; Region: PE; pfam00934
1205675003387	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1205675003388	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1205675003389	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675003390	NAD(P) binding site [chemical binding]; other site
1205675003391	active site
1205675003392	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1205675003393	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1205675003394	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
1205675003395	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1205675003396	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1205675003397	TPP-binding site [chemical binding]; other site
1205675003398	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1205675003399	dimer interface [polypeptide binding]; other site
1205675003400	PYR/PP interface [polypeptide binding]; other site
1205675003401	TPP binding site [chemical binding]; other site
1205675003402	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1205675003403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675003404	putative substrate translocation pore; other site
1205675003405	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675003406	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
1205675003407	RNase_H superfamily; Region: RNase_H_2; pfam13482
1205675003408	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1205675003409	Part of AAA domain; Region: AAA_19; pfam13245
1205675003410	AAA domain; Region: AAA_12; pfam13087
1205675003411	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
1205675003412	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1205675003413	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1205675003414	ATP binding site [chemical binding]; other site
1205675003415	Mg++ binding site [ion binding]; other site
1205675003416	motif III; other site
1205675003417	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1205675003418	nucleotide binding region [chemical binding]; other site
1205675003419	ATP-binding site [chemical binding]; other site
1205675003420	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1205675003421	putative RNA binding site [nucleotide binding]; other site
1205675003422	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1205675003423	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675003424	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675003425	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675003426	FAD binding domain; Region: FAD_binding_4; pfam01565
1205675003427	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1205675003428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675003429	H+ Antiporter protein; Region: 2A0121; TIGR00900
1205675003430	putative substrate translocation pore; other site
1205675003431	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
1205675003432	Fe-S cluster binding site [ion binding]; other site
1205675003433	DNA binding site [nucleotide binding]
1205675003434	active site
1205675003435	hypothetical protein; Validated; Region: PRK05868
1205675003436	hypothetical protein; Provisional; Region: PRK07236
1205675003437	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1205675003438	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1205675003439	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1205675003440	HIT family signature motif; other site
1205675003441	catalytic residue [active]
1205675003442	amidase; Provisional; Region: PRK12470
1205675003443	Amidase; Region: Amidase; pfam01425
1205675003444	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1205675003445	cyclase homology domain; Region: CHD; cd07302
1205675003446	nucleotidyl binding site; other site
1205675003447	metal binding site [ion binding]; metal-binding site
1205675003448	dimer interface [polypeptide binding]; other site
1205675003449	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1205675003450	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1205675003451	active site
1205675003452	ATP binding site [chemical binding]; other site
1205675003453	substrate binding site [chemical binding]; other site
1205675003454	activation loop (A-loop); other site
1205675003455	PknH-like extracellular domain; Region: PknH_C; pfam14032
1205675003456	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1205675003457	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1205675003458	phosphopeptide binding site; other site
1205675003459	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1205675003460	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1205675003461	phosphopeptide binding site; other site
1205675003462	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
1205675003463	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1205675003464	Walker A/P-loop; other site
1205675003465	ATP binding site [chemical binding]; other site
1205675003466	Q-loop/lid; other site
1205675003467	ABC transporter signature motif; other site
1205675003468	Walker B; other site
1205675003469	D-loop; other site
1205675003470	H-loop/switch region; other site
1205675003471	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1205675003472	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1205675003473	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1205675003474	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1205675003475	active site
1205675003476	ATP binding site [chemical binding]; other site
1205675003477	substrate binding site [chemical binding]; other site
1205675003478	activation loop (A-loop); other site
1205675003479	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
1205675003480	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
1205675003481	DNA binding site [nucleotide binding]
1205675003482	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1205675003483	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1205675003484	phosphopeptide binding site; other site
1205675003485	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1205675003486	putative active site [active]
1205675003487	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
1205675003488	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
1205675003489	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1205675003490	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1205675003491	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1205675003492	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1205675003493	Walker A/P-loop; other site
1205675003494	ATP binding site [chemical binding]; other site
1205675003495	Q-loop/lid; other site
1205675003496	ABC transporter signature motif; other site
1205675003497	Walker B; other site
1205675003498	D-loop; other site
1205675003499	H-loop/switch region; other site
1205675003500	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1205675003501	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1205675003502	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1205675003503	Walker A/P-loop; other site
1205675003504	ATP binding site [chemical binding]; other site
1205675003505	Q-loop/lid; other site
1205675003506	ABC transporter signature motif; other site
1205675003507	Walker B; other site
1205675003508	D-loop; other site
1205675003509	H-loop/switch region; other site
1205675003510	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1205675003511	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1205675003512	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1205675003513	catalytic core [active]
1205675003514	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1205675003515	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1205675003516	active site
1205675003517	metal binding site [ion binding]; metal-binding site
1205675003518	DNA binding site [nucleotide binding]
1205675003519	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1205675003520	Walker A/P-loop; other site
1205675003521	ATP binding site [chemical binding]; other site
1205675003522	choline dehydrogenase; Validated; Region: PRK02106
1205675003523	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1205675003524	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1205675003525	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1205675003526	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1205675003527	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
1205675003528	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1205675003529	Walker A/P-loop; other site
1205675003530	ATP binding site [chemical binding]; other site
1205675003531	Q-loop/lid; other site
1205675003532	ABC transporter signature motif; other site
1205675003533	Walker B; other site
1205675003534	D-loop; other site
1205675003535	H-loop/switch region; other site
1205675003536	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1205675003537	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1205675003538	Walker A/P-loop; other site
1205675003539	ATP binding site [chemical binding]; other site
1205675003540	Q-loop/lid; other site
1205675003541	ABC transporter signature motif; other site
1205675003542	Walker B; other site
1205675003543	D-loop; other site
1205675003544	H-loop/switch region; other site
1205675003545	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1205675003546	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1205675003547	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675003548	dimer interface [polypeptide binding]; other site
1205675003549	conserved gate region; other site
1205675003550	putative PBP binding loops; other site
1205675003551	ABC-ATPase subunit interface; other site
1205675003552	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1205675003553	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675003554	dimer interface [polypeptide binding]; other site
1205675003555	conserved gate region; other site
1205675003556	putative PBP binding loops; other site
1205675003557	ABC-ATPase subunit interface; other site
1205675003558	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1205675003559	active site clefts [active]
1205675003560	zinc binding site [ion binding]; other site
1205675003561	dimer interface [polypeptide binding]; other site
1205675003562	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1205675003563	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1205675003564	Active Sites [active]
1205675003565	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
1205675003566	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1205675003567	CysD dimerization site [polypeptide binding]; other site
1205675003568	G1 box; other site
1205675003569	putative GEF interaction site [polypeptide binding]; other site
1205675003570	GTP/Mg2+ binding site [chemical binding]; other site
1205675003571	Switch I region; other site
1205675003572	G2 box; other site
1205675003573	G3 box; other site
1205675003574	Switch II region; other site
1205675003575	G4 box; other site
1205675003576	G5 box; other site
1205675003577	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1205675003578	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1205675003579	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1205675003580	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1205675003581	Walker A/P-loop; other site
1205675003582	ligand-binding site [chemical binding]; other site
1205675003583	ATP binding site [chemical binding]; other site
1205675003584	Rrf2 family protein; Region: rrf2_super; TIGR00738
1205675003585	Transcriptional regulator; Region: Rrf2; pfam02082
1205675003586	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1205675003587	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1205675003588	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1205675003589	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1205675003590	Putative esterase; Region: Esterase; pfam00756
1205675003591	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1205675003592	Predicted membrane protein [Function unknown]; Region: COG4325
1205675003593	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
1205675003594	Evidence 4 : Homologs of previously reported genes of unknown function
1205675003595	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1205675003596	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675003597	Walker A motif; other site
1205675003598	ATP binding site [chemical binding]; other site
1205675003599	Walker B motif; other site
1205675003600	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675003601	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1205675003602	Integrase core domain; Region: rve; pfam00665
1205675003603	Integrase core domain; Region: rve_3; cl15866
1205675003604	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675003605	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1205675003606	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1205675003607	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1205675003608	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1205675003609	active site
1205675003610	HIGH motif; other site
1205675003611	KMSK motif region; other site
1205675003612	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1205675003613	tRNA binding surface [nucleotide binding]; other site
1205675003614	anticodon binding site; other site
1205675003615	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1205675003616	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1205675003617	active site
1205675003618	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1205675003619	substrate binding site [chemical binding]; other site
1205675003620	catalytic residues [active]
1205675003621	dimer interface [polypeptide binding]; other site
1205675003622	homoserine dehydrogenase; Provisional; Region: PRK06349
1205675003623	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1205675003624	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1205675003625	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1205675003626	threonine synthase; Reviewed; Region: PRK06721
1205675003627	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1205675003628	homodimer interface [polypeptide binding]; other site
1205675003629	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675003630	catalytic residue [active]
1205675003631	Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083
1205675003632	transcription termination factor Rho; Provisional; Region: PRK12678
1205675003633	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1205675003634	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1205675003635	RNA binding site [nucleotide binding]; other site
1205675003636	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1205675003637	multimer interface [polypeptide binding]; other site
1205675003638	Walker A motif; other site
1205675003639	ATP binding site [chemical binding]; other site
1205675003640	Walker B motif; other site
1205675003641	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1205675003642	peptide chain release factor 1; Region: prfA; TIGR00019
1205675003643	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1205675003644	RF-1 domain; Region: RF-1; pfam00472
1205675003645	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1205675003646	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675003647	S-adenosylmethionine binding site [chemical binding]; other site
1205675003648	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1205675003649	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1205675003650	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1205675003651	Mg++ binding site [ion binding]; other site
1205675003652	putative catalytic motif [active]
1205675003653	substrate binding site [chemical binding]; other site
1205675003654	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1205675003655	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1205675003656	F0F1 ATP synthase subunit C; Validated; Region: PRK05880
1205675003657	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1205675003658	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1205675003659	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428
1205675003660	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1205675003661	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
1205675003662	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1205675003663	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1205675003664	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1205675003665	Walker A motif; other site
1205675003666	ATP binding site [chemical binding]; other site
1205675003667	Walker B motif; other site
1205675003668	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1205675003669	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1205675003670	core domain interface [polypeptide binding]; other site
1205675003671	delta subunit interface [polypeptide binding]; other site
1205675003672	epsilon subunit interface [polypeptide binding]; other site
1205675003673	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1205675003674	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1205675003675	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1205675003676	alpha subunit interaction interface [polypeptide binding]; other site
1205675003677	Walker A motif; other site
1205675003678	ATP binding site [chemical binding]; other site
1205675003679	Walker B motif; other site
1205675003680	inhibitor binding site; inhibition site
1205675003681	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1205675003682	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1205675003683	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1205675003684	gamma subunit interface [polypeptide binding]; other site
1205675003685	epsilon subunit interface [polypeptide binding]; other site
1205675003686	LBP interface [polypeptide binding]; other site
1205675003687	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
1205675003688	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
1205675003689	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1205675003690	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1205675003691	hinge; other site
1205675003692	active site
1205675003693	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
1205675003694	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1205675003695	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1205675003696	DNA binding site [nucleotide binding]
1205675003697	active site
1205675003698	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 15525680, 9781872; Product type pe : putative enzyme
1205675003699	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator
1205675003700	HAMP domain; Region: HAMP; pfam00672
1205675003701	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1205675003702	cyclase homology domain; Region: CHD; cd07302
1205675003703	nucleotidyl binding site; other site
1205675003704	metal binding site [ion binding]; metal-binding site
1205675003705	dimer interface [polypeptide binding]; other site
1205675003706	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1205675003707	dimerization interface [polypeptide binding]; other site
1205675003708	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1205675003709	cyclase homology domain; Region: CHD; cd07302
1205675003710	nucleotidyl binding site; other site
1205675003711	metal binding site [ion binding]; metal-binding site
1205675003712	dimer interface [polypeptide binding]; other site
1205675003713	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1205675003714	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1205675003715	dimerization interface [polypeptide binding]; other site
1205675003716	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1205675003717	cyclase homology domain; Region: CHD; cd07302
1205675003718	nucleotidyl binding site; other site
1205675003719	metal binding site [ion binding]; metal-binding site
1205675003720	dimer interface [polypeptide binding]; other site
1205675003721	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
1205675003722	hypothetical protein; Provisional; Region: PRK03298
1205675003723	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1205675003724	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1205675003725	dimer interface [polypeptide binding]; other site
1205675003726	substrate binding site [chemical binding]; other site
1205675003727	metal binding site [ion binding]; metal-binding site
1205675003728	putative acyltransferase; Provisional; Region: PRK05790
1205675003729	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1205675003730	dimer interface [polypeptide binding]; other site
1205675003731	active site
1205675003732	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1205675003733	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
1205675003734	Evidence 5 : No homology to any previously reported sequences
1205675003735	Evidence 4 : Homologs of previously reported genes of unknown function
1205675003736	glycogen branching enzyme; Provisional; Region: PRK05402
1205675003737	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1205675003738	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1205675003739	active site
1205675003740	catalytic site [active]
1205675003741	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1205675003742	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
1205675003743	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
1205675003744	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1205675003745	active site
1205675003746	homodimer interface [polypeptide binding]; other site
1205675003747	catalytic site [active]
1205675003748	acceptor binding site [chemical binding]; other site
1205675003749	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
1205675003750	putative homodimer interface [polypeptide binding]; other site
1205675003751	putative active site pocket [active]
1205675003752	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
1205675003753	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1205675003754	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1205675003755	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1205675003756	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1205675003757	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1205675003758	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1205675003759	active site
1205675003760	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
1205675003761	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
1205675003762	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
1205675003763	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
1205675003764	putative active site pocket [active]
1205675003765	cleavage site
1205675003766	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
1205675003767	MPN+ (JAMM) motif; other site
1205675003768	Zinc-binding site [ion binding]; other site
1205675003769	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1205675003770	MoaE interaction surface [polypeptide binding]; other site
1205675003771	MoeB interaction surface [polypeptide binding]; other site
1205675003772	thiocarboxylated glycine; other site
1205675003773	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1205675003774	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1205675003775	dimer interface [polypeptide binding]; other site
1205675003776	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675003777	catalytic residue [active]
1205675003778	Rhomboid family; Region: Rhomboid; pfam01694
1205675003779	glutamate racemase; Provisional; Region: PRK00865
1205675003780	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1205675003781	ribonuclease PH; Reviewed; Region: rph; PRK00173
1205675003782	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1205675003783	hexamer interface [polypeptide binding]; other site
1205675003784	active site
1205675003785	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1205675003786	active site
1205675003787	dimerization interface [polypeptide binding]; other site
1205675003788	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1205675003789	Glucitol operon activator [Transcription]; Region: GutM; COG4578
1205675003790	acyl carrier protein; Validated; Region: PRK05883
1205675003791	long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851
1205675003792	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1205675003793	acyl-activating enzyme (AAE) consensus motif; other site
1205675003794	active site
1205675003795	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675003796	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675003797	active site
1205675003798	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1205675003799	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
1205675003800	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1205675003801	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1205675003802	FAD binding pocket [chemical binding]; other site
1205675003803	FAD binding motif [chemical binding]; other site
1205675003804	phosphate binding motif [ion binding]; other site
1205675003805	NAD binding pocket [chemical binding]; other site
1205675003806	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1205675003807	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1205675003808	Walker A/P-loop; other site
1205675003809	ATP binding site [chemical binding]; other site
1205675003810	Q-loop/lid; other site
1205675003811	ABC transporter signature motif; other site
1205675003812	Walker B; other site
1205675003813	D-loop; other site
1205675003814	H-loop/switch region; other site
1205675003815	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1205675003816	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1205675003817	Walker A/P-loop; other site
1205675003818	ATP binding site [chemical binding]; other site
1205675003819	Q-loop/lid; other site
1205675003820	ABC transporter signature motif; other site
1205675003821	Walker B; other site
1205675003822	D-loop; other site
1205675003823	H-loop/switch region; other site
1205675003824	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1205675003825	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675003826	NAD(P) binding site [chemical binding]; other site
1205675003827	active site
1205675003828	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1205675003829	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675003830	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1205675003831	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1205675003832	GAF domain; Region: GAF; pfam01590
1205675003833	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1205675003834	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1205675003835	metal binding site [ion binding]; metal-binding site
1205675003836	active site
1205675003837	I-site; other site
1205675003838	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1205675003839	hypothetical protein; Provisional; Region: PRK07877
1205675003840	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
1205675003841	ATP binding site [chemical binding]; other site
1205675003842	substrate interface [chemical binding]; other site
1205675003843	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1205675003844	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1205675003845	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1205675003846	cyclase homology domain; Region: CHD; cd07302
1205675003847	nucleotidyl binding site; other site
1205675003848	dimer interface [polypeptide binding]; other site
1205675003849	metal binding site [ion binding]; metal-binding site
1205675003850	AAA ATPase domain; Region: AAA_16; pfam13191
1205675003851	Predicted ATPase [General function prediction only]; Region: COG3903
1205675003852	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1205675003853	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1205675003854	DNA binding residues [nucleotide binding]
1205675003855	dimerization interface [polypeptide binding]; other site
1205675003856	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1205675003857	cyclase homology domain; Region: CHD; cd07302
1205675003858	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
1205675003859	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1205675003860	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675003861	PPE family; Region: PPE; pfam00823
1205675003862	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675003863	PAS fold; Region: PAS_4; pfam08448
1205675003864	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1205675003865	putative active site [active]
1205675003866	heme pocket [chemical binding]; other site
1205675003867	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1205675003868	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1205675003869	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1205675003870	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1205675003871	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1205675003872	anti sigma factor interaction site; other site
1205675003873	regulatory phosphorylation site [posttranslational modification]; other site
1205675003874	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1205675003875	anti sigma factor interaction site; other site
1205675003876	regulatory phosphorylation site [posttranslational modification]; other site
1205675003877	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1205675003878	synthetase active site [active]
1205675003879	NTP binding site [chemical binding]; other site
1205675003880	metal binding site [ion binding]; metal-binding site
1205675003881	Beta-lactamase; Region: Beta-lactamase; pfam00144
1205675003882	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1205675003883	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
1205675003884	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; pfam00173
1205675003885	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1205675003886	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
1205675003887	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
1205675003888	malonyl-CoA binding site [chemical binding]; other site
1205675003889	dimer interface [polypeptide binding]; other site
1205675003890	active site
1205675003891	product binding site; other site
1205675003892	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
1205675003893	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1205675003894	uncharacterized domain; Region: TIGR00702
1205675003895	YcaO-like family; Region: YcaO; pfam02624
1205675003896	Uncharacterized conserved protein [Function unknown]; Region: COG3482
1205675003897	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675003898	S-adenosylmethionine binding site [chemical binding]; other site
1205675003899	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675003900	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675003901	active site
1205675003902	bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205
1205675003903	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1205675003904	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1205675003905	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1205675003906	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1205675003907	dihydroorotase; Validated; Region: pyrC; PRK09357
1205675003908	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1205675003909	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1205675003910	active site
1205675003911	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1205675003912	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1205675003913	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1205675003914	catalytic site [active]
1205675003915	subunit interface [polypeptide binding]; other site
1205675003916	Predicted ATPase [General function prediction only]; Region: COG4637
1205675003917	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1205675003918	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
1205675003919	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1205675003920	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1205675003921	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1205675003922	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1205675003923	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1205675003924	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1205675003925	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1205675003926	IMP binding site; other site
1205675003927	dimer interface [polypeptide binding]; other site
1205675003928	interdomain contacts; other site
1205675003929	partial ornithine binding site; other site
1205675003930	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1205675003931	active site
1205675003932	dimer interface [polypeptide binding]; other site
1205675003933	PE family; Region: PE; pfam00934
1205675003934	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675003935	PPE family; Region: PPE; pfam00823
1205675003936	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1205675003937	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1205675003938	catalytic site [active]
1205675003939	G-X2-G-X-G-K; other site
1205675003940	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
1205675003941	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1205675003942	Flavoprotein; Region: Flavoprotein; pfam02441
1205675003943	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1205675003944	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1205675003945	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1205675003946	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1205675003947	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1205675003948	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1205675003949	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1205675003950	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675003951	Cytochrome P450; Region: p450; cl12078
1205675003952	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1205675003953	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1205675003954	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1205675003955	PE family; Region: PE; pfam00934
1205675003956	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1205675003957	oligomeric interface; other site
1205675003958	putative active site [active]
1205675003959	homodimer interface [polypeptide binding]; other site
1205675003960	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1205675003961	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1205675003962	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1205675003963	substrate binding pocket [chemical binding]; other site
1205675003964	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1205675003965	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1205675003966	substrate binding pocket [chemical binding]; other site
1205675003967	Predicted membrane protein [Function unknown]; Region: COG3714
1205675003968	primosome assembly protein PriA; Provisional; Region: PRK14873
1205675003969	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675003970	S-adenosylmethionine binding site [chemical binding]; other site
1205675003971	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1205675003972	MarR family; Region: MarR; pfam01047
1205675003973	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675003974	S-adenosylmethionine binding site [chemical binding]; other site
1205675003975	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1205675003976	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1205675003977	putative active site [active]
1205675003978	substrate binding site [chemical binding]; other site
1205675003979	putative cosubstrate binding site; other site
1205675003980	catalytic site [active]
1205675003981	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1205675003982	substrate binding site [chemical binding]; other site
1205675003983	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
1205675003984	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
1205675003985	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
1205675003986	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1205675003987	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1205675003988	substrate binding site [chemical binding]; other site
1205675003989	hexamer interface [polypeptide binding]; other site
1205675003990	metal binding site [ion binding]; metal-binding site
1205675003991	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1205675003992	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1205675003993	catalytic motif [active]
1205675003994	Zn binding site [ion binding]; other site
1205675003995	RibD C-terminal domain; Region: RibD_C; pfam01872
1205675003996	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1205675003997	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675003998	putative substrate translocation pore; other site
1205675003999	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
1205675004000	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1205675004001	Lumazine binding domain; Region: Lum_binding; pfam00677
1205675004002	Lumazine binding domain; Region: Lum_binding; pfam00677
1205675004003	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1205675004004	catalytic residue [active]
1205675004005	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1205675004006	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1205675004007	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1205675004008	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1205675004009	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1205675004010	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1205675004011	dimerization interface [polypeptide binding]; other site
1205675004012	active site
1205675004013	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1205675004014	homopentamer interface [polypeptide binding]; other site
1205675004015	active site
1205675004016	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1205675004017	PknH-like extracellular domain; Region: PknH_C; pfam14032
1205675004018	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1205675004019	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1205675004020	putative sugar binding sites [chemical binding]; other site
1205675004021	Q-X-W motif; other site
1205675004022	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1205675004023	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1205675004024	GIY-YIG motif/motif A; other site
1205675004025	active site
1205675004026	catalytic site [active]
1205675004027	putative DNA binding site [nucleotide binding]; other site
1205675004028	metal binding site [ion binding]; metal-binding site
1205675004029	UvrB/uvrC motif; Region: UVR; pfam02151
1205675004030	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1205675004031	Helix-hairpin-helix motif; Region: HHH; pfam00633
1205675004032	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
1205675004033	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1205675004034	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1205675004035	phosphate binding site [ion binding]; other site
1205675004036	putative substrate binding pocket [chemical binding]; other site
1205675004037	dimer interface [polypeptide binding]; other site
1205675004038	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1205675004039	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1205675004040	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1205675004041	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1205675004042	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1205675004043	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1205675004044	acyl-CoA synthetase; Provisional; Region: PRK13382
1205675004045	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1205675004046	acyl-activating enzyme (AAE) consensus motif; other site
1205675004047	putative AMP binding site [chemical binding]; other site
1205675004048	putative active site [active]
1205675004049	putative CoA binding site [chemical binding]; other site
1205675004050	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1205675004051	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
1205675004052	putative acyl-acceptor binding pocket; other site
1205675004053	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1205675004054	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1205675004055	PE family; Region: PE; pfam00934
1205675004056	PE-PPE domain; Region: PE-PPE; pfam08237
1205675004057	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
1205675004058	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1205675004059	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1205675004060	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1205675004061	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1205675004062	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1205675004063	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1205675004064	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1205675004065	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1205675004066	Phosphoglycerate kinase; Region: PGK; pfam00162
1205675004067	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1205675004068	substrate binding site [chemical binding]; other site
1205675004069	hinge regions; other site
1205675004070	ADP binding site [chemical binding]; other site
1205675004071	catalytic site [active]
1205675004072	triosephosphate isomerase; Provisional; Region: PRK14567
1205675004073	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1205675004074	substrate binding site [chemical binding]; other site
1205675004075	dimer interface [polypeptide binding]; other site
1205675004076	catalytic triad [active]
1205675004077	SnoaL-like domain; Region: SnoaL_2; pfam12680
1205675004078	Preprotein translocase SecG subunit; Region: SecG; cl09123
1205675004079	PE family; Region: PE; pfam00934
1205675004080	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
1205675004081	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
1205675004082	molybdopterin cofactor binding site [chemical binding]; other site
1205675004083	substrate binding site [chemical binding]; other site
1205675004084	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
1205675004085	molybdopterin cofactor binding site; other site
1205675004086	hydrophobic ligand binding site; other site
1205675004087	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1205675004088	Filoviridae VP35; Region: Filo_VP35; pfam02097
1205675004089	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1205675004090	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1205675004091	putative active site [active]
1205675004092	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
1205675004093	Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429
1205675004094	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1205675004095	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1205675004096	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1205675004097	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
1205675004098	putative active site [active]
1205675004099	transaldolase; Provisional; Region: PRK03903
1205675004100	catalytic residue [active]
1205675004101	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1205675004102	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1205675004103	TPP-binding site [chemical binding]; other site
1205675004104	dimer interface [polypeptide binding]; other site
1205675004105	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1205675004106	PYR/PP interface [polypeptide binding]; other site
1205675004107	dimer interface [polypeptide binding]; other site
1205675004108	TPP binding site [chemical binding]; other site
1205675004109	PE family; Region: PE; pfam00934
1205675004110	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1205675004111	UbiA prenyltransferase family; Region: UbiA; pfam01040
1205675004112	PE family; Region: PE; pfam00934
1205675004113	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1205675004114	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1205675004115	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1205675004116	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1205675004117	NADP binding site [chemical binding]; other site
1205675004118	dimer interface [polypeptide binding]; other site
1205675004119	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1205675004120	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1205675004121	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1205675004122	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1205675004123	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1205675004124	Walker A/P-loop; other site
1205675004125	ATP binding site [chemical binding]; other site
1205675004126	Q-loop/lid; other site
1205675004127	ABC transporter signature motif; other site
1205675004128	Walker B; other site
1205675004129	D-loop; other site
1205675004130	H-loop/switch region; other site
1205675004131	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1205675004132	Predicted transcriptional regulator [Transcription]; Region: COG2345
1205675004133	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1205675004134	dimerization interface [polypeptide binding]; other site
1205675004135	putative DNA binding site [nucleotide binding]; other site
1205675004136	putative Zn2+ binding site [ion binding]; other site
1205675004137	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1205675004138	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1205675004139	protein-splicing catalytic site; other site
1205675004140	thioester formation/cholesterol transfer; other site
1205675004141	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
1205675004142	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
1205675004143	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1205675004144	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1205675004145	FeS assembly protein SufD; Region: sufD; TIGR01981
1205675004146	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1205675004147	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1205675004148	Walker A/P-loop; other site
1205675004149	ATP binding site [chemical binding]; other site
1205675004150	Q-loop/lid; other site
1205675004151	ABC transporter signature motif; other site
1205675004152	Walker B; other site
1205675004153	D-loop; other site
1205675004154	H-loop/switch region; other site
1205675004155	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1205675004156	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1205675004157	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1205675004158	catalytic residue [active]
1205675004159	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1205675004160	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1205675004161	trimerization site [polypeptide binding]; other site
1205675004162	active site
1205675004163	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1205675004164	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1205675004165	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1205675004166	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675004167	active site
1205675004168	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1205675004169	PE family; Region: PE; pfam00934
1205675004170	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1205675004171	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1205675004172	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1205675004173	catalytic residues [active]
1205675004174	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1205675004175	catalytic residues [active]
1205675004176	enoyl-CoA hydratase; Provisional; Region: PRK05864
1205675004177	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675004178	substrate binding site [chemical binding]; other site
1205675004179	oxyanion hole (OAH) forming residues; other site
1205675004180	trimer interface [polypeptide binding]; other site
1205675004181	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1205675004182	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1205675004183	Walker A/P-loop; other site
1205675004184	ATP binding site [chemical binding]; other site
1205675004185	Q-loop/lid; other site
1205675004186	ABC transporter signature motif; other site
1205675004187	Walker B; other site
1205675004188	D-loop; other site
1205675004189	H-loop/switch region; other site
1205675004190	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1205675004191	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675004192	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675004193	aconitate hydratase; Validated; Region: PRK09277
1205675004194	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1205675004195	substrate binding site [chemical binding]; other site
1205675004196	ligand binding site [chemical binding]; other site
1205675004197	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1205675004198	substrate binding site [chemical binding]; other site
1205675004199	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1205675004200	NlpC/P60 family; Region: NLPC_P60; pfam00877
1205675004201	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1205675004202	NlpC/P60 family; Region: NLPC_P60; pfam00877
1205675004203	MoxR-like ATPases [General function prediction only]; Region: COG0714
1205675004204	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675004205	Walker A motif; other site
1205675004206	ATP binding site [chemical binding]; other site
1205675004207	Walker B motif; other site
1205675004208	arginine finger; other site
1205675004209	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1205675004210	Protein of unknown function DUF58; Region: DUF58; pfam01882
1205675004211	hypothetical protein; Provisional; Region: PRK13685
1205675004212	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1205675004213	metal ion-dependent adhesion site (MIDAS); other site
1205675004214	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1205675004215	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1205675004216	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1205675004217	NAD(P) binding site [chemical binding]; other site
1205675004218	homotetramer interface [polypeptide binding]; other site
1205675004219	homodimer interface [polypeptide binding]; other site
1205675004220	active site
1205675004221	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
1205675004222	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1205675004223	NAD binding site [chemical binding]; other site
1205675004224	homotetramer interface [polypeptide binding]; other site
1205675004225	homodimer interface [polypeptide binding]; other site
1205675004226	substrate binding site [chemical binding]; other site
1205675004227	active site
1205675004228	ferrochelatase; Reviewed; Region: hemH; PRK00035
1205675004229	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1205675004230	C-terminal domain interface [polypeptide binding]; other site
1205675004231	active site
1205675004232	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1205675004233	active site
1205675004234	N-terminal domain interface [polypeptide binding]; other site
1205675004235	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
1205675004236	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1205675004237	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1205675004238	DoxX-like family; Region: DoxX_2; pfam13564
1205675004239	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
1205675004240	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1205675004241	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1205675004242	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
1205675004243	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
1205675004244	heterodimer interface [polypeptide binding]; other site
1205675004245	substrate interaction site [chemical binding]; other site
1205675004246	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1205675004247	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
1205675004248	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
1205675004249	active site
1205675004250	substrate binding site [chemical binding]; other site
1205675004251	coenzyme B12 binding site [chemical binding]; other site
1205675004252	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
1205675004253	B12 binding site [chemical binding]; other site
1205675004254	cobalt ligand [ion binding]; other site
1205675004255	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1205675004256	membrane ATPase/protein kinase; Provisional; Region: PRK09435
1205675004257	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
1205675004258	Walker A; other site
1205675004259	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1205675004260	Beta-lactamase; Region: Beta-lactamase; pfam00144
1205675004261	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1205675004262	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675004263	S-adenosylmethionine binding site [chemical binding]; other site
1205675004264	Uncharacterized conserved protein [Function unknown]; Region: COG3360
1205675004265	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1205675004266	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1205675004267	Ligand binding site; other site
1205675004268	Putative Catalytic site; other site
1205675004269	DXD motif; other site
1205675004270	Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285
1205675004271	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
1205675004272	active site
1205675004273	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1205675004274	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1205675004275	inhibitor-cofactor binding pocket; inhibition site
1205675004276	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675004277	catalytic residue [active]
1205675004278	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1205675004279	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1205675004280	putative trimer interface [polypeptide binding]; other site
1205675004281	putative CoA binding site [chemical binding]; other site
1205675004282	Methyltransferase domain; Region: Methyltransf_12; pfam08242
1205675004283	S-adenosylmethionine binding site [chemical binding]; other site
1205675004284	WbqC-like protein family; Region: WbqC; pfam08889
1205675004285	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1205675004286	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675004287	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675004288	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1205675004289	Methyltransferase domain; Region: Methyltransf_12; pfam08242
1205675004290	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1205675004291	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1205675004292	NADP-binding site; other site
1205675004293	homotetramer interface [polypeptide binding]; other site
1205675004294	substrate binding site [chemical binding]; other site
1205675004295	homodimer interface [polypeptide binding]; other site
1205675004296	active site
1205675004297	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1205675004298	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1205675004299	NADP binding site [chemical binding]; other site
1205675004300	active site
1205675004301	putative substrate binding site [chemical binding]; other site
1205675004302	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1205675004303	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
1205675004304	metal-binding site
1205675004305	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675004306	S-adenosylmethionine binding site [chemical binding]; other site
1205675004307	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1205675004308	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1205675004309	active site
1205675004310	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
1205675004311	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1205675004312	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1205675004313	active site
1205675004314	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
1205675004315	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1205675004316	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1205675004317	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1205675004318	active site
1205675004319	acyl-CoA synthetase; Validated; Region: PRK05850
1205675004320	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1205675004321	acyl-activating enzyme (AAE) consensus motif; other site
1205675004322	active site
1205675004323	Transport protein; Region: actII; TIGR00833
1205675004324	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1205675004325	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675004326	S-adenosylmethionine binding site [chemical binding]; other site
1205675004327	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1205675004328	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1205675004329	homodimer interface [polypeptide binding]; other site
1205675004330	active site
1205675004331	TDP-binding site; other site
1205675004332	acceptor substrate-binding pocket; other site
1205675004333	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1205675004334	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1205675004335	Probable Catalytic site; other site
1205675004336	metal-binding site
1205675004337	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1205675004338	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1205675004339	homodimer interface [polypeptide binding]; other site
1205675004340	active site
1205675004341	TDP-binding site; other site
1205675004342	acceptor substrate-binding pocket; other site
1205675004343	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12775759, 15525680, 16573683; Product type pe : putative enzyme
1205675004344	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12775759, 15525680, 16573683; Product type pe : putative enzyme
1205675004345	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1205675004346	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675004347	active site
1205675004348	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
1205675004349	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1205675004350	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675004351	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1205675004352	Enoylreductase; Region: PKS_ER; smart00829
1205675004353	NAD(P) binding site [chemical binding]; other site
1205675004354	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1205675004355	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1205675004356	putative NADP binding site [chemical binding]; other site
1205675004357	active site
1205675004358	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675004359	Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12368446, 12657046, 16573683
1205675004360	Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12368446, 12657046, 16573683
1205675004361	acyl-CoA synthetase; Validated; Region: PRK05850
1205675004362	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1205675004363	acyl-activating enzyme (AAE) consensus motif; other site
1205675004364	active site
1205675004365	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1205675004366	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1205675004367	NAD(P) binding site [chemical binding]; other site
1205675004368	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1205675004369	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1205675004370	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1205675004371	CoenzymeA binding site [chemical binding]; other site
1205675004372	subunit interaction site [polypeptide binding]; other site
1205675004373	PHB binding site; other site
1205675004374	Nitronate monooxygenase; Region: NMO; pfam03060
1205675004375	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1205675004376	FMN binding site [chemical binding]; other site
1205675004377	substrate binding site [chemical binding]; other site
1205675004378	putative catalytic residue [active]
1205675004379	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675004380	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
1205675004381	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1205675004382	HIGH motif; other site
1205675004383	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1205675004384	active site
1205675004385	KMSKS motif; other site
1205675004386	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
1205675004387	tRNA binding surface [nucleotide binding]; other site
1205675004388	anticodon binding site; other site
1205675004389	DNA polymerase IV; Provisional; Region: PRK03348
1205675004390	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1205675004391	active site
1205675004392	DNA binding site [nucleotide binding]
1205675004393	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1205675004394	active site
1205675004395	homodimer interface [polypeptide binding]; other site
1205675004396	homotetramer interface [polypeptide binding]; other site
1205675004397	lipoprotein signal peptidase; Provisional; Region: PRK14764
1205675004398	lipoprotein signal peptidase; Provisional; Region: PRK14787
1205675004399	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1205675004400	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1205675004401	active site
1205675004402	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
1205675004403	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1205675004404	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
1205675004405	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1205675004406	apolar tunnel; other site
1205675004407	heme binding site [chemical binding]; other site
1205675004408	dimerization interface [polypeptide binding]; other site
1205675004409	short chain dehydrogenase; Provisional; Region: PRK05866
1205675004410	classical (c) SDRs; Region: SDR_c; cd05233
1205675004411	NAD(P) binding site [chemical binding]; other site
1205675004412	active site
1205675004413	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1205675004414	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675004415	NAD(P) binding site [chemical binding]; other site
1205675004416	active site
1205675004417	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1205675004418	hydrophobic ligand binding site; other site
1205675004419	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1205675004420	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1205675004421	active site
1205675004422	PHP Thumb interface [polypeptide binding]; other site
1205675004423	metal binding site [ion binding]; metal-binding site
1205675004424	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1205675004425	generic binding surface II; other site
1205675004426	generic binding surface I; other site
1205675004427	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675004428	PPE family; Region: PPE; pfam00823
1205675004429	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675004430	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1205675004431	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1205675004432	acyl-activating enzyme (AAE) consensus motif; other site
1205675004433	putative AMP binding site [chemical binding]; other site
1205675004434	putative active site [active]
1205675004435	putative CoA binding site [chemical binding]; other site
1205675004436	glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915
1205675004437	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
1205675004438	putative acyl-acceptor binding pocket; other site
1205675004439	fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176
1205675004440	L-aspartate oxidase; Provisional; Region: PRK06175
1205675004441	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1205675004442	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
1205675004443	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1205675004444	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
1205675004445	Iron-sulfur protein interface; other site
1205675004446	proximal heme binding site [chemical binding]; other site
1205675004447	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
1205675004448	Iron-sulfur protein interface; other site
1205675004449	proximal quinone binding site [chemical binding]; other site
1205675004450	C-subunit interface; other site
1205675004451	distal quinone binding site; other site
1205675004452	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675004453	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675004454	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1205675004455	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1205675004456	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1205675004457	threonine dehydratase; Validated; Region: PRK08639
1205675004458	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1205675004459	tetramer interface [polypeptide binding]; other site
1205675004460	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675004461	catalytic residue [active]
1205675004462	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
1205675004463	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1205675004464	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1205675004465	putative active site [active]
1205675004466	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
1205675004467	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
1205675004468	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
1205675004469	catalytic site [active]
1205675004470	active site
1205675004471	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1205675004472	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
1205675004473	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
1205675004474	active site
1205675004475	catalytic site [active]
1205675004476	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1205675004477	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1205675004478	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1205675004479	active site
1205675004480	catalytic site [active]
1205675004481	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1205675004482	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1205675004483	NlpC/P60 family; Region: NLPC_P60; pfam00877
1205675004484	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
1205675004485	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1205675004486	inhibitor-cofactor binding pocket; inhibition site
1205675004487	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675004488	catalytic residue [active]
1205675004489	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1205675004490	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1205675004491	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1205675004492	catalytic residue [active]
1205675004493	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1205675004494	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
1205675004495	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675004496	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675004497	active site
1205675004498	biotin synthase; Validated; Region: PRK06256
1205675004499	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1205675004500	FeS/SAM binding site; other site
1205675004501	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1205675004502	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
1205675004503	Secretory lipase; Region: LIP; pfam03583
1205675004504	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
1205675004505	nudix motif; other site
1205675004506	quinolinate synthetase; Provisional; Region: PRK09375
1205675004507	L-aspartate oxidase; Provisional; Region: PRK07804
1205675004508	L-aspartate oxidase; Provisional; Region: PRK06175
1205675004509	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1205675004510	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
1205675004511	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1205675004512	dimerization interface [polypeptide binding]; other site
1205675004513	active site
1205675004514	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675004515	S-adenosylmethionine binding site [chemical binding]; other site
1205675004516	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
1205675004517	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
1205675004518	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1205675004519	NAD binding site [chemical binding]; other site
1205675004520	dimerization interface [polypeptide binding]; other site
1205675004521	product binding site; other site
1205675004522	substrate binding site [chemical binding]; other site
1205675004523	zinc binding site [ion binding]; other site
1205675004524	catalytic residues [active]
1205675004525	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
1205675004526	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1205675004527	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675004528	homodimer interface [polypeptide binding]; other site
1205675004529	catalytic residue [active]
1205675004530	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1205675004531	4-fold oligomerization interface [polypeptide binding]; other site
1205675004532	putative active site pocket [active]
1205675004533	metal binding residues [ion binding]; metal-binding site
1205675004534	3-fold/trimer interface [polypeptide binding]; other site
1205675004535	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1205675004536	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1205675004537	putative active site [active]
1205675004538	oxyanion strand; other site
1205675004539	catalytic triad [active]
1205675004540	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1205675004541	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1205675004542	catalytic residues [active]
1205675004543	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1205675004544	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1205675004545	active site
1205675004546	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1205675004547	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1205675004548	substrate binding site [chemical binding]; other site
1205675004549	glutamase interaction surface [polypeptide binding]; other site
1205675004550	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1205675004551	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
1205675004552	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1205675004553	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1205675004554	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1205675004555	catalytic triad [active]
1205675004556	anthranilate synthase component I; Provisional; Region: PRK13571
1205675004557	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1205675004558	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1205675004559	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
1205675004560	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1205675004561	active site
1205675004562	ribulose/triose binding site [chemical binding]; other site
1205675004563	phosphate binding site [ion binding]; other site
1205675004564	substrate (anthranilate) binding pocket [chemical binding]; other site
1205675004565	product (indole) binding pocket [chemical binding]; other site
1205675004566	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1205675004567	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1205675004568	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675004569	catalytic residue [active]
1205675004570	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1205675004571	substrate binding site [chemical binding]; other site
1205675004572	active site
1205675004573	catalytic residues [active]
1205675004574	heterodimer interface [polypeptide binding]; other site
1205675004575	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
1205675004576	Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682
1205675004577	TM2 domain; Region: TM2; pfam05154
1205675004578	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
1205675004579	pyruvate kinase; Provisional; Region: PRK06247
1205675004580	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1205675004581	domain interfaces; other site
1205675004582	active site
1205675004583	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1205675004584	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1205675004585	active site
1205675004586	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1205675004587	catalytic triad [active]
1205675004588	dimer interface [polypeptide binding]; other site
1205675004589	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1205675004590	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1205675004591	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
1205675004592	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1205675004593	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1205675004594	Walker A/P-loop; other site
1205675004595	Walker A/P-loop; other site
1205675004596	ATP binding site [chemical binding]; other site
1205675004597	ATP binding site [chemical binding]; other site
1205675004598	Q-loop/lid; other site
1205675004599	ABC transporter signature motif; other site
1205675004600	Walker B; other site
1205675004601	D-loop; other site
1205675004602	H-loop/switch region; other site
1205675004603	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1205675004604	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1205675004605	Walker A/P-loop; other site
1205675004606	ATP binding site [chemical binding]; other site
1205675004607	Q-loop/lid; other site
1205675004608	ABC transporter signature motif; other site
1205675004609	Walker B; other site
1205675004610	D-loop; other site
1205675004611	H-loop/switch region; other site
1205675004612	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1205675004613	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1205675004614	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1205675004615	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1205675004616	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1205675004617	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
1205675004618	cyclase homology domain; Region: CHD; cd07302
1205675004619	nucleotidyl binding site; other site
1205675004620	metal binding site [ion binding]; metal-binding site
1205675004621	dimer interface [polypeptide binding]; other site
1205675004622	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1205675004623	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1205675004624	active site
1205675004625	phosphorylation site [posttranslational modification]
1205675004626	intermolecular recognition site; other site
1205675004627	dimerization interface [polypeptide binding]; other site
1205675004628	ANTAR domain; Region: ANTAR; pfam03861
1205675004629	lipid-transfer protein; Provisional; Region: PRK06059
1205675004630	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1205675004631	active site
1205675004632	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
1205675004633	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
1205675004634	DUF35 OB-fold domain; Region: DUF35; pfam01796
1205675004635	DNA polymerase I; Provisional; Region: PRK05755
1205675004636	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1205675004637	active site
1205675004638	metal binding site 1 [ion binding]; metal-binding site
1205675004639	putative 5' ssDNA interaction site; other site
1205675004640	metal binding site 3; metal-binding site
1205675004641	metal binding site 2 [ion binding]; metal-binding site
1205675004642	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1205675004643	putative DNA binding site [nucleotide binding]; other site
1205675004644	putative metal binding site [ion binding]; other site
1205675004645	3'-5' exonuclease; Region: 35EXOc; smart00474
1205675004646	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1205675004647	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1205675004648	active site
1205675004649	DNA binding site [nucleotide binding]
1205675004650	catalytic site [active]
1205675004651	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
1205675004652	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1205675004653	RNA binding site [nucleotide binding]; other site
1205675004654	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1205675004655	RNA binding site [nucleotide binding]; other site
1205675004656	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1205675004657	RNA binding site [nucleotide binding]; other site
1205675004658	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1205675004659	RNA binding site [nucleotide binding]; other site
1205675004660	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
1205675004661	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1205675004662	CoA-binding site [chemical binding]; other site
1205675004663	ATP-binding [chemical binding]; other site
1205675004664	Uncharacterized conserved protein [Function unknown]; Region: GrpB; COG2320
1205675004665	Predicted RNA-binding protein, associated with RNAses E/G family [General function prediction only]; Region: COG2306
1205675004666	excinuclease ABC subunit B; Provisional; Region: PRK05298
1205675004667	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1205675004668	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1205675004669	nucleotide binding region [chemical binding]; other site
1205675004670	ATP-binding site [chemical binding]; other site
1205675004671	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1205675004672	UvrB/uvrC motif; Region: UVR; pfam02151
1205675004673	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675004674	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1205675004675	putative substrate translocation pore; other site
1205675004676	Predicted membrane protein [Function unknown]; Region: COG5305
1205675004677	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1205675004678	Ligand Binding Site [chemical binding]; other site
1205675004679	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1205675004680	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1205675004681	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1205675004682	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1205675004683	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1205675004684	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1205675004685	Predicted esterase [General function prediction only]; Region: COG0627
1205675004686	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
1205675004687	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1205675004688	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1205675004689	dimer interface [polypeptide binding]; other site
1205675004690	putative anticodon binding site; other site
1205675004691	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1205675004692	motif 1; other site
1205675004693	dimer interface [polypeptide binding]; other site
1205675004694	active site
1205675004695	motif 2; other site
1205675004696	motif 3; other site
1205675004697	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1205675004698	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1205675004699	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1205675004700	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1205675004701	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1205675004702	23S rRNA binding site [nucleotide binding]; other site
1205675004703	L21 binding site [polypeptide binding]; other site
1205675004704	L13 binding site [polypeptide binding]; other site
1205675004705	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1205675004706	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1205675004707	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
1205675004708	PE family; Region: PE; pfam00934
1205675004709	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1205675004710	cyclase homology domain; Region: CHD; cd07302
1205675004711	nucleotidyl binding site; other site
1205675004712	metal binding site [ion binding]; metal-binding site
1205675004713	dimer interface [polypeptide binding]; other site
1205675004714	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1205675004715	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1205675004716	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1205675004717	dimer interface [polypeptide binding]; other site
1205675004718	motif 1; other site
1205675004719	active site
1205675004720	motif 2; other site
1205675004721	motif 3; other site
1205675004722	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1205675004723	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1205675004724	putative tRNA-binding site [nucleotide binding]; other site
1205675004725	B3/4 domain; Region: B3_4; pfam03483
1205675004726	tRNA synthetase B5 domain; Region: B5; smart00874
1205675004727	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1205675004728	dimer interface [polypeptide binding]; other site
1205675004729	motif 1; other site
1205675004730	motif 3; other site
1205675004731	motif 2; other site
1205675004732	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1205675004733	PE family; Region: PE; pfam00934
1205675004734	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
1205675004735	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1205675004736	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1205675004737	heterotetramer interface [polypeptide binding]; other site
1205675004738	active site pocket [active]
1205675004739	cleavage site
1205675004740	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1205675004741	feedback inhibition sensing region; other site
1205675004742	homohexameric interface [polypeptide binding]; other site
1205675004743	nucleotide binding site [chemical binding]; other site
1205675004744	N-acetyl-L-glutamate binding site [chemical binding]; other site
1205675004745	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
1205675004746	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1205675004747	inhibitor-cofactor binding pocket; inhibition site
1205675004748	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675004749	catalytic residue [active]
1205675004750	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1205675004751	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1205675004752	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1205675004753	arginine repressor; Region: argR_whole; TIGR01529
1205675004754	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1205675004755	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1205675004756	argininosuccinate synthase; Provisional; Region: PRK13820
1205675004757	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1205675004758	ANP binding site [chemical binding]; other site
1205675004759	Substrate Binding Site II [chemical binding]; other site
1205675004760	Substrate Binding Site I [chemical binding]; other site
1205675004761	argininosuccinate lyase; Provisional; Region: PRK00855
1205675004762	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1205675004763	active sites [active]
1205675004764	tetramer interface [polypeptide binding]; other site
1205675004765	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
1205675004766	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
1205675004767	malonyl-CoA binding site [chemical binding]; other site
1205675004768	dimer interface [polypeptide binding]; other site
1205675004769	active site
1205675004770	product binding site; other site
1205675004771	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1205675004772	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675004773	active site
1205675004774	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1205675004775	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1205675004776	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675004777	Enoylreductase; Region: PKS_ER; smart00829
1205675004778	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1205675004779	NAD(P) binding site [chemical binding]; other site
1205675004780	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
1205675004781	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1205675004782	putative NADP binding site [chemical binding]; other site
1205675004783	active site
1205675004784	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675004785	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1205675004786	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675004787	active site
1205675004788	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1205675004789	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1205675004790	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675004791	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1205675004792	Enoylreductase; Region: PKS_ER; smart00829
1205675004793	NAD(P) binding site [chemical binding]; other site
1205675004794	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
1205675004795	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1205675004796	putative NADP binding site [chemical binding]; other site
1205675004797	active site
1205675004798	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675004799	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1205675004800	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675004801	active site
1205675004802	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1205675004803	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1205675004804	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675004805	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
1205675004806	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
1205675004807	malonyl-CoA binding site [chemical binding]; other site
1205675004808	dimer interface [polypeptide binding]; other site
1205675004809	active site
1205675004810	product binding site; other site
1205675004811	Cytochrome P450; Region: p450; cl12078
1205675004812	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675004813	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1205675004814	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1205675004815	ABC transporter; Region: ABC_tran_2; pfam12848
1205675004816	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1205675004817	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
1205675004818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675004819	putative substrate translocation pore; other site
1205675004820	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1205675004821	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1205675004822	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1205675004823	dimerization interface [polypeptide binding]; other site
1205675004824	putative DNA binding site [nucleotide binding]; other site
1205675004825	putative Zn2+ binding site [ion binding]; other site
1205675004826	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1205675004827	active site residue [active]
1205675004828	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1205675004829	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1205675004830	ligand binding site [chemical binding]; other site
1205675004831	flexible hinge region; other site
1205675004832	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1205675004833	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
1205675004834	putative catalytic residues [active]
1205675004835	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
1205675004836	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1205675004837	catalytic residues [active]
1205675004838	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675004839	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1205675004840	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1205675004841	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1205675004842	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1205675004843	substrate binding pocket [chemical binding]; other site
1205675004844	membrane-bound complex binding site; other site
1205675004845	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1205675004846	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1205675004847	FeS/SAM binding site; other site
1205675004848	DivIVA protein; Region: DivIVA; pfam05103
1205675004849	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1205675004850	acyl-CoA synthetase; Validated; Region: PRK07868
1205675004851	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
1205675004852	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675004853	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675004854	acyl-activating enzyme (AAE) consensus motif; other site
1205675004855	AMP binding site [chemical binding]; other site
1205675004856	active site
1205675004857	CoA binding site [chemical binding]; other site
1205675004858	Uncharacterized conserved protein [Function unknown]; Region: COG2835
1205675004859	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675004860	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675004861	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
1205675004862	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1205675004863	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1205675004864	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
1205675004865	Walker A/P-loop; other site
1205675004866	ATP binding site [chemical binding]; other site
1205675004867	Q-loop/lid; other site
1205675004868	ABC transporter signature motif; other site
1205675004869	Walker B; other site
1205675004870	D-loop; other site
1205675004871	H-loop/switch region; other site
1205675004872	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1205675004873	active site
1205675004874	DNA binding site [nucleotide binding]
1205675004875	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1205675004876	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1205675004877	active site
1205675004878	HIGH motif; other site
1205675004879	dimer interface [polypeptide binding]; other site
1205675004880	KMSKS motif; other site
1205675004881	S4 RNA-binding domain; Region: S4; smart00363
1205675004882	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1205675004883	Tetratrico peptide repeat; Region: TPR_5; pfam12688
1205675004884	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1205675004885	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
1205675004886	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1205675004887	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1205675004888	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1205675004889	RNA binding surface [nucleotide binding]; other site
1205675004890	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675004891	S-adenosylmethionine binding site [chemical binding]; other site
1205675004892	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
1205675004893	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1205675004894	DNA repair protein RecN; Region: recN; TIGR00634
1205675004895	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1205675004896	Walker A/P-loop; other site
1205675004897	ATP binding site [chemical binding]; other site
1205675004898	Q-loop/lid; other site
1205675004899	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1205675004900	ABC transporter signature motif; other site
1205675004901	Walker B; other site
1205675004902	D-loop; other site
1205675004903	H-loop/switch region; other site
1205675004904	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
1205675004905	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
1205675004906	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
1205675004907	CTP synthetase; Validated; Region: pyrG; PRK05380
1205675004908	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1205675004909	Catalytic site [active]
1205675004910	active site
1205675004911	UTP binding site [chemical binding]; other site
1205675004912	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1205675004913	active site
1205675004914	putative oxyanion hole; other site
1205675004915	catalytic triad [active]
1205675004916	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1205675004917	dimer interface [polypeptide binding]; other site
1205675004918	ADP-ribose binding site [chemical binding]; other site
1205675004919	active site
1205675004920	nudix motif; other site
1205675004921	metal binding site [ion binding]; metal-binding site
1205675004922	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1205675004923	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1205675004924	active site
1205675004925	DNA binding site [nucleotide binding]
1205675004926	Int/Topo IB signature motif; other site
1205675004927	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675004928	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675004929	active site
1205675004930	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1205675004931	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675004932	S-adenosylmethionine binding site [chemical binding]; other site
1205675004933	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1205675004934	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675004935	PPE family; Region: PPE; pfam00823
1205675004936	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675004937	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675004938	PPE family; Region: PPE; pfam00823
1205675004939	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675004940	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1205675004941	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1205675004942	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1205675004943	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1205675004944	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1205675004945	P-loop; other site
1205675004946	Magnesium ion binding site [ion binding]; other site
1205675004947	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1205675004948	Magnesium ion binding site [ion binding]; other site
1205675004949	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1205675004950	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
1205675004951	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1205675004952	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1205675004953	RNA binding surface [nucleotide binding]; other site
1205675004954	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1205675004955	active site
1205675004956	cytidylate kinase; Provisional; Region: cmk; PRK00023
1205675004957	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1205675004958	CMP-binding site; other site
1205675004959	The sites determining sugar specificity; other site
1205675004960	GTP-binding protein Der; Reviewed; Region: PRK03003
1205675004961	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1205675004962	GTP/Mg2+ binding site [chemical binding]; other site
1205675004963	Switch I region; other site
1205675004964	G2 box; other site
1205675004965	Switch II region; other site
1205675004966	G3 box; other site
1205675004967	G4 box; other site
1205675004968	G5 box; other site
1205675004969	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1205675004970	G1 box; other site
1205675004971	GTP/Mg2+ binding site [chemical binding]; other site
1205675004972	Switch I region; other site
1205675004973	G2 box; other site
1205675004974	G3 box; other site
1205675004975	Switch II region; other site
1205675004976	G4 box; other site
1205675004977	G5 box; other site
1205675004978	short chain dehydrogenase; Provisional; Region: PRK07060
1205675004979	classical (c) SDRs; Region: SDR_c; cd05233
1205675004980	NAD(P) binding site [chemical binding]; other site
1205675004981	active site
1205675004982	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1205675004983	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1205675004984	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1205675004985	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1205675004986	Cupin domain; Region: Cupin_2; pfam07883
1205675004987	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1205675004988	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1205675004989	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1205675004990	putative switch regulator; other site
1205675004991	non-specific DNA interactions [nucleotide binding]; other site
1205675004992	DNA binding site [nucleotide binding]
1205675004993	sequence specific DNA binding site [nucleotide binding]; other site
1205675004994	putative cAMP binding site [chemical binding]; other site
1205675004995	Bacterial transcriptional regulator; Region: IclR; pfam01614
1205675004996	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
1205675004997	putative active site [active]
1205675004998	homotetrameric interface [polypeptide binding]; other site
1205675004999	metal binding site [ion binding]; metal-binding site
1205675005000	biotin carboxylase-like protein; Validated; Region: PRK06524
1205675005001	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1205675005002	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1205675005003	Beta-lactamase; Region: Beta-lactamase; pfam00144
1205675005004	Predicted transcriptional regulators [Transcription]; Region: COG1733
1205675005005	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1205675005006	dimerization interface [polypeptide binding]; other site
1205675005007	putative DNA binding site [nucleotide binding]; other site
1205675005008	putative Zn2+ binding site [ion binding]; other site
1205675005009	Predicted transcriptional regulators [Transcription]; Region: COG1733
1205675005010	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1205675005011	FAD binding domain; Region: FAD_binding_4; pfam01565
1205675005012	Berberine and berberine like; Region: BBE; pfam08031
1205675005013	TIGR03086 family protein; Region: TIGR03086
1205675005014	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1205675005015	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675005016	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1205675005017	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1205675005018	Beta-lactamase; Region: Beta-lactamase; pfam00144
1205675005019	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
1205675005020	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
1205675005021	NAD(P) binding site [chemical binding]; other site
1205675005022	catalytic residues [active]
1205675005023	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
1205675005024	putative catalytic residue [active]
1205675005025	Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 12657046, 12775759, 12843072, 15525680, 17443846, 16806798; Product type e : enzyme
1205675005026	Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 12657046, 12775759, 12843072, 15525680, 17443846, 16806798; Product type e : enzyme
1205675005027	Evidence 1c : Function experimentally demonstrated in the studied genus; PubMedId : 12657046, 12775759, 12843072, 15525680, 17443846, 16806798; Product type e : enzyme
1205675005028	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675005029	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
1205675005030	putative substrate translocation pore; other site
1205675005031	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
1205675005032	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1205675005033	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1205675005034	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1205675005035	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1205675005036	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
1205675005037	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1205675005038	putative active site [active]
1205675005039	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
1205675005040	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1205675005041	active site
1205675005042	ATP binding site [chemical binding]; other site
1205675005043	substrate binding site [chemical binding]; other site
1205675005044	activation loop (A-loop); other site
1205675005045	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1205675005046	Thioredoxin; Region: Thioredoxin_4; cl17273
1205675005047	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
1205675005048	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
1205675005049	active site
1205675005050	metal binding site [ion binding]; metal-binding site
1205675005051	nudix motif; other site
1205675005052	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1205675005053	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1205675005054	active site
1205675005055	ATP binding site [chemical binding]; other site
1205675005056	substrate binding site [chemical binding]; other site
1205675005057	activation loop (A-loop); other site
1205675005058	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1205675005059	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1205675005060	phosphopeptide binding site; other site
1205675005061	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1205675005062	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1205675005063	phosphopeptide binding site; other site
1205675005064	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
1205675005065	The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955
1205675005066	Walker A/P-loop; other site
1205675005067	ATP binding site [chemical binding]; other site
1205675005068	Q-loop/lid; other site
1205675005069	ABC transporter signature motif; other site
1205675005070	Walker B; other site
1205675005071	D-loop; other site
1205675005072	H-loop/switch region; other site
1205675005073	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1205675005074	acyl-CoA synthetase; Provisional; Region: PRK13388
1205675005075	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675005076	acyl-activating enzyme (AAE) consensus motif; other site
1205675005077	AMP binding site [chemical binding]; other site
1205675005078	active site
1205675005079	CoA binding site [chemical binding]; other site
1205675005080	hypothetical protein; Provisional; Region: PRK06185
1205675005081	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1205675005082	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1205675005083	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1205675005084	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1205675005085	Transposase; Region: HTH_Tnp_1; cl17663
1205675005086	putative transposase OrfB; Reviewed; Region: PHA02517
1205675005087	HTH-like domain; Region: HTH_21; pfam13276
1205675005088	Integrase core domain; Region: rve; pfam00665
1205675005089	Integrase core domain; Region: rve_3; pfam13683
1205675005090	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675005091	PPE family; Region: PPE; pfam00823
1205675005092	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675005093	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675005094	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
1205675005095	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1205675005096	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
1205675005097	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1205675005098	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1205675005099	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1205675005100	sulfite oxidase; Provisional; Region: PLN00177
1205675005101	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
1205675005102	Moco binding site; other site
1205675005103	metal coordination site [ion binding]; other site
1205675005104	dimerization interface [polypeptide binding]; other site
1205675005105	Transport protein; Region: actII; TIGR00833
1205675005106	Cutinase; Region: Cutinase; pfam01083
1205675005107	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1205675005108	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1205675005109	Uncharacterized conserved protein [Function unknown]; Region: COG0393
1205675005110	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
1205675005111	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675005112	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675005113	active site
1205675005114	Integrase core domain; Region: rve; pfam00665
1205675005115	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1205675005116	putative homotetramer interface [polypeptide binding]; other site
1205675005117	putative homodimer interface [polypeptide binding]; other site
1205675005118	putative allosteric switch controlling residues; other site
1205675005119	putative metal binding site [ion binding]; other site
1205675005120	putative homodimer-homodimer interface [polypeptide binding]; other site
1205675005121	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1205675005122	PE family; Region: PE; pfam00934
1205675005123	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1205675005124	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
1205675005125	dimer interface [polypeptide binding]; other site
1205675005126	active site
1205675005127	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1205675005128	substrate binding site [chemical binding]; other site
1205675005129	catalytic residue [active]
1205675005130	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
1205675005131	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1205675005132	metal binding site [ion binding]; metal-binding site
1205675005133	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
1205675005134	FAD binding domain; Region: FAD_binding_4; pfam01565
1205675005135	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1205675005136	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1205675005137	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1205675005138	Bacterial transcriptional regulator; Region: IclR; pfam01614
1205675005139	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1205675005140	FAD binding domain; Region: FAD_binding_4; pfam01565
1205675005141	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675005142	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675005143	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675005144	Cytochrome P450; Region: p450; cl12078
1205675005145	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
1205675005146	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
1205675005147	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
1205675005148	Protein of unknown function (DUF690); Region: DUF690; pfam05108
1205675005149	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1205675005150	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1205675005151	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1205675005152	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1205675005153	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675005154	Cytochrome P450; Region: p450; cl12078
1205675005155	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1205675005156	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675005157	PPE family; Region: PPE; pfam00823
1205675005158	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675005159	PE family; Region: PE; pfam00934
1205675005160	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1205675005161	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1205675005162	EspG family; Region: ESX-1_EspG; pfam14011
1205675005163	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1205675005164	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1205675005165	catalytic residues [active]
1205675005166	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1205675005167	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
1205675005168	active site
1205675005169	catalytic residues [active]
1205675005170	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
1205675005171	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
1205675005172	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675005173	Walker A motif; other site
1205675005174	ATP binding site [chemical binding]; other site
1205675005175	Walker B motif; other site
1205675005176	arginine finger; other site
1205675005177	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675005178	PPE family; Region: PPE; pfam00823
1205675005179	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675005180	PPE family; Region: PPE; pfam00823
1205675005181	PE family; Region: PE; pfam00934
1205675005182	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1205675005183	PE family; Region: PE; pfam00934
1205675005184	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675005185	PPE family; Region: PPE; pfam00823
1205675005186	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675005187	PPE family; Region: PPE; pfam00823
1205675005188	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675005189	PPE family; Region: PPE; pfam00823
1205675005190	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675005191	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1205675005192	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1205675005193	MgtC family; Region: MgtC; pfam02308
1205675005194	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1205675005195	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1205675005196	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
1205675005197	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1205675005198	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1205675005199	hypothetical protein; Validated; Region: PRK07121
1205675005200	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1205675005201	ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472
1205675005202	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1205675005203	hypothetical protein; Provisional; Region: PRK05858
1205675005204	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1205675005205	PYR/PP interface [polypeptide binding]; other site
1205675005206	dimer interface [polypeptide binding]; other site
1205675005207	TPP binding site [chemical binding]; other site
1205675005208	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1205675005209	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
1205675005210	TPP-binding site; other site
1205675005211	dimer interface [polypeptide binding]; other site
1205675005212	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
1205675005213	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1205675005214	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1205675005215	nucleotide binding region [chemical binding]; other site
1205675005216	ATP-binding site [chemical binding]; other site
1205675005217	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1205675005218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
1205675005219	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1205675005220	Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856
1205675005221	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
1205675005222	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
1205675005223	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1205675005224	lipoyl attachment site [posttranslational modification]; other site
1205675005225	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1205675005226	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1205675005227	phosphopeptide binding site; other site
1205675005228	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1205675005229	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1205675005230	DNA binding residues [nucleotide binding]
1205675005231	Bifunctional nuclease; Region: DNase-RNase; pfam02577
1205675005232	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1205675005233	DNA binding residues [nucleotide binding]
1205675005234	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1205675005235	putative dimer interface [polypeptide binding]; other site
1205675005236	glycine dehydrogenase; Provisional; Region: PRK05367
1205675005237	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1205675005238	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675005239	tetramer interface [polypeptide binding]; other site
1205675005240	catalytic residue [active]
1205675005241	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1205675005242	tetramer interface [polypeptide binding]; other site
1205675005243	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675005244	catalytic residue [active]
1205675005245	haloalkane dehalogenase; Provisional; Region: PRK03204
1205675005246	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1205675005247	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
1205675005248	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1205675005249	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1205675005250	metal ion-dependent adhesion site (MIDAS); other site
1205675005251	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
1205675005252	active site
1205675005253	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1205675005254	putative active site [active]
1205675005255	Evidence 4 : Homologs of previously reported genes of unknown function
1205675005256	Evidence 4 : Homologs of previously reported genes of unknown function
1205675005257	Domain of unknown function DUF21; Region: DUF21; pfam01595
1205675005258	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1205675005259	FOG: CBS domain [General function prediction only]; Region: COG0517
1205675005260	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1205675005261	Domain of unknown function DUF21; Region: DUF21; pfam01595
1205675005262	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1205675005263	Transporter associated domain; Region: CorC_HlyC; smart01091
1205675005264	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
1205675005265	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1205675005266	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1205675005267	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1205675005268	active site
1205675005269	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1205675005270	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1205675005271	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1205675005272	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1205675005273	Predicted transcriptional regulator [Transcription]; Region: COG3682
1205675005274	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1205675005275	CoenzymeA binding site [chemical binding]; other site
1205675005276	subunit interaction site [polypeptide binding]; other site
1205675005277	PHB binding site; other site
1205675005278	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1205675005279	alpha-gamma subunit interface [polypeptide binding]; other site
1205675005280	beta-gamma subunit interface [polypeptide binding]; other site
1205675005281	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1205675005282	gamma-beta subunit interface [polypeptide binding]; other site
1205675005283	alpha-beta subunit interface [polypeptide binding]; other site
1205675005284	urease subunit alpha; Reviewed; Region: ureC; PRK13206
1205675005285	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1205675005286	subunit interactions [polypeptide binding]; other site
1205675005287	active site
1205675005288	flap region; other site
1205675005289	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1205675005290	UreF; Region: UreF; pfam01730
1205675005291	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1205675005292	UreD urease accessory protein; Region: UreD; cl00530
1205675005293	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1205675005294	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1205675005295	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
1205675005296	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1205675005297	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1205675005298	classical (c) SDRs; Region: SDR_c; cd05233
1205675005299	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
1205675005300	NAD(P) binding site [chemical binding]; other site
1205675005301	active site
1205675005302	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1205675005303	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1205675005304	sulfate transport protein; Provisional; Region: cysT; CHL00187
1205675005305	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675005306	dimer interface [polypeptide binding]; other site
1205675005307	conserved gate region; other site
1205675005308	putative PBP binding loops; other site
1205675005309	ABC-ATPase subunit interface; other site
1205675005310	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1205675005311	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1205675005312	Walker A/P-loop; other site
1205675005313	ATP binding site [chemical binding]; other site
1205675005314	Q-loop/lid; other site
1205675005315	ABC transporter signature motif; other site
1205675005316	Walker B; other site
1205675005317	D-loop; other site
1205675005318	H-loop/switch region; other site
1205675005319	TOBE domain; Region: TOBE; pfam03459
1205675005320	Fibronectin-attachment protein (FAP); Region: FAP; pfam07174
1205675005321	Predicted membrane protein [Function unknown]; Region: COG2261
1205675005322	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
1205675005323	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822
1205675005324	putative NAD(P) binding site [chemical binding]; other site
1205675005325	putative substrate binding site [chemical binding]; other site
1205675005326	catalytic Zn binding site [ion binding]; other site
1205675005327	structural Zn binding site [ion binding]; other site
1205675005328	CAAX protease self-immunity; Region: Abi; pfam02517
1205675005329	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1205675005330	MOSC domain; Region: MOSC; pfam03473
1205675005331	short chain dehydrogenase; Provisional; Region: PRK07825
1205675005332	classical (c) SDRs; Region: SDR_c; cd05233
1205675005333	NAD(P) binding site [chemical binding]; other site
1205675005334	active site
1205675005335	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1205675005336	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1205675005337	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1205675005338	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1205675005339	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
1205675005340	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1205675005341	active site
1205675005342	hypothetical protein; Provisional; Region: PRK12320
1205675005343	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675005344	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1205675005345	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1205675005346	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1205675005347	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1205675005348	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
1205675005349	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1205675005350	active site
1205675005351	substrate binding site [chemical binding]; other site
1205675005352	FMN binding site [chemical binding]; other site
1205675005353	putative catalytic residues [active]
1205675005354	Uncharacterized conserved protein [Function unknown]; Region: COG5579
1205675005355	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1205675005356	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
1205675005357	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1205675005358	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1205675005359	heme binding site [chemical binding]; other site
1205675005360	ferroxidase pore; other site
1205675005361	ferroxidase diiron center [ion binding]; other site
1205675005362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675005363	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1205675005364	putative substrate translocation pore; other site
1205675005365	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675005366	putative substrate translocation pore; other site
1205675005367	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333
1205675005368	23S rRNA interface [nucleotide binding]; other site
1205675005369	L3 interface [polypeptide binding]; other site
1205675005370	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1205675005371	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1205675005372	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1205675005373	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1205675005374	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675005375	Cytochrome P450; Region: p450; cl12078
1205675005376	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
1205675005377	short chain dehydrogenase; Provisional; Region: PRK08267
1205675005378	classical (c) SDR, subgroup 9; Region: SDR_c9; cd08931
1205675005379	putative NAD(P) binding site [chemical binding]; other site
1205675005380	active site
1205675005381	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1205675005382	hydrophobic ligand binding site; other site
1205675005383	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1205675005384	chorismate mutase; Provisional; Region: PRK09269
1205675005385	chorismate mutase, putative; Region: CM_mono2; TIGR01806
1205675005386	Putative esterase; Region: Esterase; pfam00756
1205675005387	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675005388	Leucine carboxyl methyltransferase; Region: LCM; cl01306
1205675005389	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675005390	Leucine carboxyl methyltransferase; Region: LCM; cl01306
1205675005391	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1205675005392	Nitronate monooxygenase; Region: NMO; pfam03060
1205675005393	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1205675005394	FMN binding site [chemical binding]; other site
1205675005395	substrate binding site [chemical binding]; other site
1205675005396	putative catalytic residue [active]
1205675005397	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284
1205675005398	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1205675005399	catalytic Zn binding site [ion binding]; other site
1205675005400	NAD(P) binding site [chemical binding]; other site
1205675005401	structural Zn binding site [ion binding]; other site
1205675005402	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675005403	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1205675005404	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1205675005405	putative active site [active]
1205675005406	dimerization interface [polypeptide binding]; other site
1205675005407	putative tRNAtyr binding site [nucleotide binding]; other site
1205675005408	Domain of unknown function DUF77; Region: DUF77; pfam01910
1205675005409	Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330
1205675005410	putative ADP-ribose binding site [chemical binding]; other site
1205675005411	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675005412	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1205675005413	cyclase homology domain; Region: CHD; cd07302
1205675005414	nucleotidyl binding site; other site
1205675005415	metal binding site [ion binding]; metal-binding site
1205675005416	dimer interface [polypeptide binding]; other site
1205675005417	competence damage-inducible protein A; Provisional; Region: PRK00549
1205675005418	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1205675005419	putative MPT binding site; other site
1205675005420	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
1205675005421	putative sialic acid transporter; Region: 2A0112; TIGR00891
1205675005422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675005423	putative substrate translocation pore; other site
1205675005424	Predicted membrane protein [Function unknown]; Region: COG1950
1205675005425	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1205675005426	anti sigma factor interaction site; other site
1205675005427	regulatory phosphorylation site [posttranslational modification]; other site
1205675005428	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1205675005429	Domain of unknown function (DUF4262); Region: DUF4262; pfam14081
1205675005430	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1205675005431	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
1205675005432	dimer interface [polypeptide binding]; other site
1205675005433	active site
1205675005434	heme binding site [chemical binding]; other site
1205675005435	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1205675005436	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1205675005437	metal binding site 2 [ion binding]; metal-binding site
1205675005438	putative DNA binding helix; other site
1205675005439	metal binding site 1 [ion binding]; metal-binding site
1205675005440	dimer interface [polypeptide binding]; other site
1205675005441	structural Zn2+ binding site [ion binding]; other site
1205675005442	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1205675005443	substrate binding site [chemical binding]; other site
1205675005444	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1205675005445	substrate binding site [chemical binding]; other site
1205675005446	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1205675005447	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275
1205675005448	putative NAD(P) binding site [chemical binding]; other site
1205675005449	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1205675005450	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1205675005451	tetramer interface [polypeptide binding]; other site
1205675005452	active site
1205675005453	Mg2+/Mn2+ binding site [ion binding]; other site
1205675005454	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
1205675005455	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675005456	PPE family; Region: PPE; pfam00823
1205675005457	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675005458	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675005459	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675005460	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675005461	PPE family; Region: PPE; pfam00823
1205675005462	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675005463	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675005464	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1205675005465	putative hydrophobic ligand binding site [chemical binding]; other site
1205675005466	protein interface [polypeptide binding]; other site
1205675005467	gate; other site
1205675005468	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1205675005469	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
1205675005470	putative acyl-acceptor binding pocket; other site
1205675005471	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1205675005472	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1205675005473	Beta-lactamase; Region: Beta-lactamase; pfam00144
1205675005474	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1205675005475	Beta-lactamase; Region: Beta-lactamase; pfam00144
1205675005476	putative fatty-acid--CoA ligase; Provisional; Region: PRK12476
1205675005477	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1205675005478	acyl-activating enzyme (AAE) consensus motif; other site
1205675005479	active site
1205675005480	Domain of unknown function (DUF1942); Region: DUF1942; pfam09167
1205675005481	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
1205675005482	Uncharacterized conserved protein [Function unknown]; Region: COG3361
1205675005483	short chain dehydrogenase; Provisional; Region: PRK05867
1205675005484	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675005485	NAD(P) binding site [chemical binding]; other site
1205675005486	active site
1205675005487	TIGR03085 family protein; Region: TIGR03085
1205675005488	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1205675005489	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
1205675005490	conserved cys residue [active]
1205675005491	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1205675005492	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1205675005493	conserved cys residue [active]
1205675005494	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1205675005495	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1205675005496	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1205675005497	dimer interface [polypeptide binding]; other site
1205675005498	catalytic triad [active]
1205675005499	peroxidatic and resolving cysteines [active]
1205675005500	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675005501	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1205675005502	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1205675005503	active site
1205675005504	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12775759, 15525680; Product type pe : putative enzyme
1205675005505	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12775759, 15525680; Product type pe : putative enzyme
1205675005506	enoyl-CoA hydratase; Provisional; Region: PRK08290
1205675005507	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675005508	substrate binding site [chemical binding]; other site
1205675005509	oxyanion hole (OAH) forming residues; other site
1205675005510	trimer interface [polypeptide binding]; other site
1205675005511	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1205675005512	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1205675005513	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
1205675005514	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1205675005515	catalytic loop [active]
1205675005516	iron binding site [ion binding]; other site
1205675005517	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
1205675005518	FAD binding pocket [chemical binding]; other site
1205675005519	FAD binding motif [chemical binding]; other site
1205675005520	phosphate binding motif [ion binding]; other site
1205675005521	beta-alpha-beta structure motif; other site
1205675005522	NAD binding pocket [chemical binding]; other site
1205675005523	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675005524	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1205675005525	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1205675005526	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
1205675005527	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1205675005528	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
1205675005529	dimerization interface [polypeptide binding]; other site
1205675005530	active site
1205675005531	classical (c) SDR, subgroup 12; Region: SDR_c12; cd08944
1205675005532	putative NAD(P) binding site [chemical binding]; other site
1205675005533	active site
1205675005534	homodimer interface [polypeptide binding]; other site
1205675005535	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1205675005536	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675005537	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675005538	active site
1205675005539	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
1205675005540	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487
1205675005541	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
1205675005542	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1205675005543	non-specific DNA binding site [nucleotide binding]; other site
1205675005544	salt bridge; other site
1205675005545	sequence-specific DNA binding site [nucleotide binding]; other site
1205675005546	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
1205675005547	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
1205675005548	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1205675005549	putative active site [active]
1205675005550	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1205675005551	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675005552	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675005553	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675005554	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675005555	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1205675005556	Permease; Region: Permease; pfam02405
1205675005557	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1205675005558	Permease; Region: Permease; pfam02405
1205675005559	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675005560	mce related protein; Region: MCE; pfam02470
1205675005561	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1205675005562	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675005563	mce related protein; Region: MCE; pfam02470
1205675005564	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675005565	mce related protein; Region: MCE; pfam02470
1205675005566	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1205675005567	mce related protein; Region: MCE; pfam02470
1205675005568	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675005569	mce related protein; Region: MCE; pfam02470
1205675005570	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675005571	mce related protein; Region: MCE; pfam02470
1205675005572	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1205675005573	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1205675005574	YacP-like NYN domain; Region: NYN_YacP; cl01491
1205675005575	PE family; Region: PE; pfam00934
1205675005576	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
1205675005577	transposase; Provisional; Region: PRK06526
1205675005578	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675005579	Walker A motif; other site
1205675005580	ATP binding site [chemical binding]; other site
1205675005581	Walker B motif; other site
1205675005582	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675005583	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1205675005584	Integrase core domain; Region: rve; pfam00665
1205675005585	Integrase core domain; Region: rve_3; cl15866
1205675005586	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675005587	Peptidase family M48; Region: Peptidase_M48; pfam01435
1205675005588	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675005589	S-adenosylmethionine binding site [chemical binding]; other site
1205675005590	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1205675005591	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1205675005592	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1205675005593	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1205675005594	dimer interface [polypeptide binding]; other site
1205675005595	putative radical transfer pathway; other site
1205675005596	diiron center [ion binding]; other site
1205675005597	tyrosyl radical; other site
1205675005598	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
1205675005599	putative active site [active]
1205675005600	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423
1205675005601	PE family; Region: PE; pfam00934
1205675005602	Cutinase; Region: Cutinase; pfam01083
1205675005603	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
1205675005604	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1205675005605	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1205675005606	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1205675005607	dimerization interface [polypeptide binding]; other site
1205675005608	Lysine efflux permease [General function prediction only]; Region: COG1279
1205675005609	Cellulose binding domain; Region: CBM_2; pfam00553
1205675005610	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1205675005611	Transposase; Region: HTH_Tnp_1; cl17663
1205675005612	putative transposase OrfB; Reviewed; Region: PHA02517
1205675005613	HTH-like domain; Region: HTH_21; pfam13276
1205675005614	Integrase core domain; Region: rve; pfam00665
1205675005615	Integrase core domain; Region: rve_3; pfam13683
1205675005616	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675005617	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1205675005618	Integrase core domain; Region: rve; pfam00665
1205675005619	Integrase core domain; Region: rve_3; cl15866
1205675005620	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675005621	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1205675005622	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675005623	ATP binding site [chemical binding]; other site
1205675005624	Walker B motif; other site
1205675005625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1205675005626	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1205675005627	Domain of unknown function (DUF4188); Region: DUF4188; pfam13826
1205675005628	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1205675005629	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1205675005630	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1205675005631	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1205675005632	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
1205675005633	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1205675005634	dimerization interface [polypeptide binding]; other site
1205675005635	putative DNA binding site [nucleotide binding]; other site
1205675005636	putative Zn2+ binding site [ion binding]; other site
1205675005637	Hemerythrin-like domain; Region: Hr-like; cd12108
1205675005638	Fe binding site [ion binding]; other site
1205675005639	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1205675005640	Ligand Binding Site [chemical binding]; other site
1205675005641	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1205675005642	Ligand Binding Site [chemical binding]; other site
1205675005643	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1205675005644	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1205675005645	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1205675005646	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1205675005647	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1205675005648	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1205675005649	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1205675005650	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1205675005651	tetramer interface [polypeptide binding]; other site
1205675005652	active site
1205675005653	Mg2+/Mn2+ binding site [ion binding]; other site
1205675005654	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1205675005655	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1205675005656	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
1205675005657	3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341
1205675005658	homotetramer interface [polypeptide binding]; other site
1205675005659	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1205675005660	NAD binding site [chemical binding]; other site
1205675005661	homodimer interface [polypeptide binding]; other site
1205675005662	active site
1205675005663	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675005664	S-adenosylmethionine binding site [chemical binding]; other site
1205675005665	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
1205675005666	Predicted kinase [General function prediction only]; Region: COG0645
1205675005667	AAA domain; Region: AAA_17; pfam13207
1205675005668	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1205675005669	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1205675005670	Ligand Binding Site [chemical binding]; other site
1205675005671	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1205675005672	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
1205675005673	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
1205675005674	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
1205675005675	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1205675005676	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1205675005677	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1205675005678	Ferredoxin [Energy production and conversion]; Region: COG1146
1205675005679	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1205675005680	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
1205675005681	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675005682	Walker A motif; other site
1205675005683	ATP binding site [chemical binding]; other site
1205675005684	Walker B motif; other site
1205675005685	arginine finger; other site
1205675005686	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1205675005687	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1205675005688	putative active site [active]
1205675005689	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1205675005690	MarR family; Region: MarR_2; pfam12802
1205675005691	Phage envelope protein [General function prediction only]; Region: COG5562
1205675005692	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1205675005693	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1205675005694	Evidence 2b : Function of strongly homologous gene; PubMedId : 12657046; Product type e : enzyme
1205675005695	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
1205675005696	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675005697	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675005698	active site
1205675005699	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1205675005700	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1205675005701	non-specific DNA binding site [nucleotide binding]; other site
1205675005702	salt bridge; other site
1205675005703	sequence-specific DNA binding site [nucleotide binding]; other site
1205675005704	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
1205675005705	Uncharacterized conserved protein [Function unknown]; Region: COG2442
1205675005706	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1205675005707	non-specific DNA binding site [nucleotide binding]; other site
1205675005708	salt bridge; other site
1205675005709	sequence-specific DNA binding site [nucleotide binding]; other site
1205675005710	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
1205675005711	AAA domain; Region: AAA_21; pfam13304
1205675005712	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1205675005713	active site
1205675005714	metal binding site [ion binding]; metal-binding site
1205675005715	Family description; Region: UvrD_C_2; pfam13538
1205675005716	Predicted helicase [General function prediction only]; Region: COG4889
1205675005717	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
1205675005718	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
1205675005719	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1205675005720	ATP binding site [chemical binding]; other site
1205675005721	putative Mg++ binding site [ion binding]; other site
1205675005722	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
1205675005723	ATP-binding site [chemical binding]; other site
1205675005724	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1205675005725	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1205675005726	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1205675005727	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1205675005728	Ligand Binding Site [chemical binding]; other site
1205675005729	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1205675005730	Ligand Binding Site [chemical binding]; other site
1205675005731	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1205675005732	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1205675005733	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1205675005734	Histidine kinase; Region: HisKA_3; pfam07730
1205675005735	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1205675005736	Ligand Binding Site [chemical binding]; other site
1205675005737	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1205675005738	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1205675005739	putative substrate binding site [chemical binding]; other site
1205675005740	putative ATP binding site [chemical binding]; other site
1205675005741	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1205675005742	active site
1205675005743	Erythromycin esterase homolog [General function prediction only]; Region: COG2312
1205675005744	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1205675005745	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1205675005746	putative dimer interface [polypeptide binding]; other site
1205675005747	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1205675005748	dimer interface [polypeptide binding]; other site
1205675005749	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
1205675005750	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1205675005751	putative DNA binding site [nucleotide binding]; other site
1205675005752	dimerization interface [polypeptide binding]; other site
1205675005753	putative Zn2+ binding site [ion binding]; other site
1205675005754	Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891
1205675005755	putative hydrophobic ligand binding site [chemical binding]; other site
1205675005756	CLM binding site; other site
1205675005757	L1 loop; other site
1205675005758	DNA binding site [nucleotide binding]
1205675005759	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1205675005760	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1205675005761	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1205675005762	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
1205675005763	nucleophile elbow; other site
1205675005764	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1205675005765	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1205675005766	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1205675005767	Walker A/P-loop; other site
1205675005768	ATP binding site [chemical binding]; other site
1205675005769	Q-loop/lid; other site
1205675005770	ABC transporter signature motif; other site
1205675005771	Walker B; other site
1205675005772	D-loop; other site
1205675005773	H-loop/switch region; other site
1205675005774	TOBE domain; Region: TOBE_2; pfam08402
1205675005775	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1205675005776	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675005777	dimer interface [polypeptide binding]; other site
1205675005778	conserved gate region; other site
1205675005779	putative PBP binding loops; other site
1205675005780	ABC-ATPase subunit interface; other site
1205675005781	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1205675005782	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675005783	dimer interface [polypeptide binding]; other site
1205675005784	conserved gate region; other site
1205675005785	putative PBP binding loops; other site
1205675005786	ABC-ATPase subunit interface; other site
1205675005787	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1205675005788	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1205675005789	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
1205675005790	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1205675005791	Isochorismatase family; Region: Isochorismatase; pfam00857
1205675005792	catalytic triad [active]
1205675005793	metal binding site [ion binding]; metal-binding site
1205675005794	conserved cis-peptide bond; other site
1205675005795	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
1205675005796	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1205675005797	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1205675005798	substrate binding pocket [chemical binding]; other site
1205675005799	catalytic triad [active]
1205675005800	hypothetical protein; Provisional; Region: PRK05865
1205675005801	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675005802	NAD(P) binding site [chemical binding]; other site
1205675005803	active site
1205675005804	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1205675005805	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1205675005806	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675005807	active site
1205675005808	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1205675005809	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1205675005810	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675005811	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1205675005812	Enoylreductase; Region: PKS_ER; smart00829
1205675005813	NAD(P) binding site [chemical binding]; other site
1205675005814	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
1205675005815	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1205675005816	putative NADP binding site [chemical binding]; other site
1205675005817	active site
1205675005818	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675005819	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1205675005820	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675005821	active site
1205675005822	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1205675005823	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1205675005824	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675005825	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1205675005826	Enoylreductase; Region: PKS_ER; smart00829
1205675005827	NAD(P) binding site [chemical binding]; other site
1205675005828	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
1205675005829	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1205675005830	putative NADP binding site [chemical binding]; other site
1205675005831	active site
1205675005832	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675005833	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
1205675005834	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
1205675005835	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1205675005836	putative active site [active]
1205675005837	catalytic triad [active]
1205675005838	putative dimer interface [polypeptide binding]; other site
1205675005839	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
1205675005840	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
1205675005841	Ligand binding site; other site
1205675005842	Putative Catalytic site; other site
1205675005843	DXD motif; other site
1205675005844	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1205675005845	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1205675005846	active site
1205675005847	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
1205675005848	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1205675005849	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
1205675005850	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1205675005851	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1205675005852	putative active site [active]
1205675005853	30S ribosomal protein S18; Provisional; Region: PRK13401
1205675005854	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1205675005855	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1205675005856	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1205675005857	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1205675005858	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1205675005859	intersubunit interface [polypeptide binding]; other site
1205675005860	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1205675005861	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1205675005862	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1205675005863	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1205675005864	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
1205675005865	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
1205675005866	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1205675005867	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1205675005868	PemK-like protein; Region: PemK; pfam02452
1205675005869	precorrin-3B synthase; Region: CobG; TIGR02435
1205675005870	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1205675005871	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1205675005872	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
1205675005873	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1205675005874	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1205675005875	active site
1205675005876	SAM binding site [chemical binding]; other site
1205675005877	homodimer interface [polypeptide binding]; other site
1205675005878	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1205675005879	active site
1205675005880	SAM binding site [chemical binding]; other site
1205675005881	homodimer interface [polypeptide binding]; other site
1205675005882	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1205675005883	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675005884	S-adenosylmethionine binding site [chemical binding]; other site
1205675005885	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1205675005886	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1205675005887	RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649
1205675005888	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1205675005889	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1205675005890	DNA binding residues [nucleotide binding]
1205675005891	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
1205675005892	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
1205675005893	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1205675005894	active site
1205675005895	SAM binding site [chemical binding]; other site
1205675005896	homodimer interface [polypeptide binding]; other site
1205675005897	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1205675005898	active site
1205675005899	putative homodimer interface [polypeptide binding]; other site
1205675005900	SAM binding site [chemical binding]; other site
1205675005901	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1205675005902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1205675005903	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675005904	NAD(P) binding site [chemical binding]; other site
1205675005905	active site
1205675005906	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1205675005907	Catalytic domain of uncharacterized Mycobacterium tuberculosis Rv2075c-like proteins; Region: PI-PLCc_Rv2075c_like; cd08590
1205675005908	putative active site [active]
1205675005909	catalytic site [active]
1205675005910	putative metal binding site [ion binding]; other site
1205675005911	C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432
1205675005912	Protein of unknown function (DUF2563); Region: DUF2563; pfam10817
1205675005913	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
1205675005914	Transposase; Region: HTH_Tnp_1; cl17663
1205675005915	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1205675005916	HTH-like domain; Region: HTH_21; pfam13276
1205675005917	Integrase core domain; Region: rve; pfam00665
1205675005918	Integrase core domain; Region: rve_3; pfam13683
1205675005919	hypothetical protein; Provisional; Region: PRK12705
1205675005920	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1205675005921	putative transposase OrfB; Reviewed; Region: PHA02517
1205675005922	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1205675005923	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1205675005924	active site
1205675005925	ATP binding site [chemical binding]; other site
1205675005926	substrate binding site [chemical binding]; other site
1205675005927	activation loop (A-loop); other site
1205675005928	PknH-like extracellular domain; Region: PknH_C; pfam14032
1205675005929	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1205675005930	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1205675005931	active site
1205675005932	5'-3' exonuclease; Region: 53EXOc; smart00475
1205675005933	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1205675005934	active site
1205675005935	metal binding site 1 [ion binding]; metal-binding site
1205675005936	putative 5' ssDNA interaction site; other site
1205675005937	metal binding site 3; metal-binding site
1205675005938	metal binding site 2 [ion binding]; metal-binding site
1205675005939	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1205675005940	putative DNA binding site [nucleotide binding]; other site
1205675005941	putative metal binding site [ion binding]; other site
1205675005942	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
1205675005943	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
1205675005944	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1205675005945	ATP binding site [chemical binding]; other site
1205675005946	putative Mg++ binding site [ion binding]; other site
1205675005947	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1205675005948	nucleotide binding region [chemical binding]; other site
1205675005949	ATP-binding site [chemical binding]; other site
1205675005950	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
1205675005951	Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945
1205675005952	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
1205675005953	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
1205675005954	Predicted transcriptional regulator [Transcription]; Region: COG2378
1205675005955	WYL domain; Region: WYL; pfam13280
1205675005956	Predicted transcriptional regulator [Transcription]; Region: COG2378
1205675005957	WYL domain; Region: WYL; pfam13280
1205675005958	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
1205675005959	PE family; Region: PE; pfam00934
1205675005960	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675005961	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675005962	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675005963	active site
1205675005964	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
1205675005965	SNF2 Helicase protein; Region: DUF3670; pfam12419
1205675005966	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1205675005967	ATP binding site [chemical binding]; other site
1205675005968	putative Mg++ binding site [ion binding]; other site
1205675005969	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1205675005970	nucleotide binding region [chemical binding]; other site
1205675005971	ATP-binding site [chemical binding]; other site
1205675005972	Uncharacterized conserved protein [Function unknown]; Region: COG4279
1205675005973	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1205675005974	putative active site [active]
1205675005975	PE family; Region: PE; pfam00934
1205675005976	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675005977	PPE family; Region: PPE; pfam00823
1205675005978	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
1205675005979	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
1205675005980	active site
1205675005981	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
1205675005982	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
1205675005983	active site
1205675005984	Pup-like protein; Region: Pup; pfam05639
1205675005985	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
1205675005986	proteasome ATPase; Region: pup_AAA; TIGR03689
1205675005987	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675005988	Walker A motif; other site
1205675005989	ATP binding site [chemical binding]; other site
1205675005990	Walker B motif; other site
1205675005991	arginine finger; other site
1205675005992	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1205675005993	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550
1205675005994	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
1205675005995	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675005996	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
1205675005997	Predicted membrane protein [Function unknown]; Region: COG3918
1205675005998	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1205675005999	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
1205675006000	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
1205675006001	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
1205675006002	homodimer interface [polypeptide binding]; other site
1205675006003	putative metal binding site [ion binding]; other site
1205675006004	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675006005	PPE family; Region: PPE; pfam00823
1205675006006	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1205675006007	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1205675006008	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1205675006009	substrate binding pocket [chemical binding]; other site
1205675006010	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1205675006011	B12 binding site [chemical binding]; other site
1205675006012	cobalt ligand [ion binding]; other site
1205675006013	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1205675006014	PAC2 family; Region: PAC2; pfam09754
1205675006015	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1205675006016	short chain dehydrogenase; Provisional; Region: PRK05872
1205675006017	classical (c) SDRs; Region: SDR_c; cd05233
1205675006018	NAD(P) binding site [chemical binding]; other site
1205675006019	active site
1205675006020	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1205675006021	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
1205675006022	active site
1205675006023	HIGH motif; other site
1205675006024	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1205675006025	active site
1205675006026	KMSKS motif; other site
1205675006027	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
1205675006028	putative tRNA binding surface [nucleotide binding]; other site
1205675006029	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1205675006030	active site
1205675006031	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1205675006032	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1205675006033	putative active site [active]
1205675006034	conserved hypothetical protein; Region: TIGR03843
1205675006035	conserved hypothetical protein; Region: TIGR03847
1205675006036	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1205675006037	catalytic core [active]
1205675006038	undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753
1205675006039	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1205675006040	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1205675006041	quinone interaction residues [chemical binding]; other site
1205675006042	active site
1205675006043	catalytic residues [active]
1205675006044	FMN binding site [chemical binding]; other site
1205675006045	substrate binding site [chemical binding]; other site
1205675006046	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1205675006047	substrate binding site [chemical binding]; other site
1205675006048	hypothetical protein; Provisional; Region: PRK07906
1205675006049	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
1205675006050	putative metal binding site [ion binding]; other site
1205675006051	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
1205675006052	putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574
1205675006053	Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 12775759
1205675006054	Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 12775759
1205675006055	DivIVA domain; Region: DivI1A_domain; TIGR03544
1205675006056	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1205675006057	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1205675006058	Predicted integral membrane protein [Function unknown]; Region: COG0762
1205675006059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1205675006060	Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325
1205675006061	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1205675006062	catalytic residue [active]
1205675006063	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1205675006064	uncharacterized protein, YfiH family; Region: TIGR00726
1205675006065	cell division protein FtsZ; Validated; Region: PRK09330
1205675006066	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1205675006067	nucleotide binding site [chemical binding]; other site
1205675006068	SulA interaction site; other site
1205675006069	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1205675006070	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1205675006071	Cell division protein FtsQ; Region: FtsQ; pfam03799
1205675006072	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1205675006073	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1205675006074	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1205675006075	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1205675006076	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1205675006077	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
1205675006078	active site
1205675006079	homodimer interface [polypeptide binding]; other site
1205675006080	cell division protein FtsW; Region: ftsW; TIGR02614
1205675006081	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369
1205675006082	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1205675006083	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1205675006084	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1205675006085	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1205675006086	Mg++ binding site [ion binding]; other site
1205675006087	putative catalytic motif [active]
1205675006088	putative substrate binding site [chemical binding]; other site
1205675006089	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
1205675006090	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1205675006091	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1205675006092	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1205675006093	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1205675006094	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1205675006095	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1205675006096	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675006097	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675006098	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1205675006099	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1205675006100	PE family; Region: PE; pfam00934
1205675006101	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1205675006102	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1205675006103	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1205675006104	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1205675006105	MraW methylase family; Region: Methyltransf_5; pfam01795
1205675006106	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
1205675006107	MraZ protein; Region: MraZ; pfam02381
1205675006108	MraZ protein; Region: MraZ; pfam02381
1205675006109	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
1205675006110	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
1205675006111	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1205675006112	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1205675006113	substrate binding pocket [chemical binding]; other site
1205675006114	chain length determination region; other site
1205675006115	substrate-Mg2+ binding site; other site
1205675006116	catalytic residues [active]
1205675006117	aspartate-rich region 1; other site
1205675006118	active site lid residues [active]
1205675006119	aspartate-rich region 2; other site
1205675006120	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1205675006121	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1205675006122	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1205675006123	active site
1205675006124	ATP binding site [chemical binding]; other site
1205675006125	substrate binding site [chemical binding]; other site
1205675006126	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1205675006127	substrate binding site [chemical binding]; other site
1205675006128	activation loop (A-loop); other site
1205675006129	activation loop (A-loop); other site
1205675006130	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1205675006131	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1205675006132	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1205675006133	Transposase; Region: HTH_Tnp_1; cl17663
1205675006134	putative transposase OrfB; Reviewed; Region: PHA02517
1205675006135	HTH-like domain; Region: HTH_21; pfam13276
1205675006136	Integrase core domain; Region: rve; pfam00665
1205675006137	Integrase core domain; Region: rve_3; pfam13683
1205675006138	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1205675006139	Integrase core domain; Region: rve; pfam00665
1205675006140	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675006141	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1205675006142	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675006143	Walker A motif; other site
1205675006144	ATP binding site [chemical binding]; other site
1205675006145	Walker B motif; other site
1205675006146	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1205675006147	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1205675006148	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200
1205675006149	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
1205675006150	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1205675006151	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1205675006152	putative acyl-acceptor binding pocket; other site
1205675006153	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1205675006154	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1205675006155	DTAP/Switch II; other site
1205675006156	Switch I; other site
1205675006157	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1205675006158	putative hydrophobic ligand binding site [chemical binding]; other site
1205675006159	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1205675006160	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1205675006161	acyl-activating enzyme (AAE) consensus motif; other site
1205675006162	putative AMP binding site [chemical binding]; other site
1205675006163	putative active site [active]
1205675006164	putative CoA binding site [chemical binding]; other site
1205675006165	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1205675006166	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1205675006167	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
1205675006168	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1205675006169	NlpC/P60 family; Region: NLPC_P60; pfam00877
1205675006170	hypothetical protein; Validated; Region: PRK07883
1205675006171	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1205675006172	active site
1205675006173	catalytic site [active]
1205675006174	substrate binding site [chemical binding]; other site
1205675006175	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1205675006176	GIY-YIG motif/motif A; other site
1205675006177	active site
1205675006178	catalytic site [active]
1205675006179	putative DNA binding site [nucleotide binding]; other site
1205675006180	metal binding site [ion binding]; metal-binding site
1205675006181	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1205675006182	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1205675006183	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1205675006184	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
1205675006185	Subunit I/III interface [polypeptide binding]; other site
1205675006186	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1205675006187	Cytochrome c; Region: Cytochrom_C; pfam00034
1205675006188	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1205675006189	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1205675006190	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1205675006191	iron-sulfur cluster [ion binding]; other site
1205675006192	[2Fe-2S] cluster binding site [ion binding]; other site
1205675006193	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1205675006194	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1205675006195	heme bH binding site [chemical binding]; other site
1205675006196	intrachain domain interface; other site
1205675006197	heme bL binding site [chemical binding]; other site
1205675006198	interchain domain interface [polypeptide binding]; other site
1205675006199	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
1205675006200	Qo binding site; other site
1205675006201	Protein of unknown function (DUF2561); Region: DUF2561; pfam10812
1205675006202	Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423
1205675006203	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
1205675006204	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1205675006205	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1205675006206	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1205675006207	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1205675006208	dimer interface [polypeptide binding]; other site
1205675006209	active site
1205675006210	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1205675006211	Ligand Binding Site [chemical binding]; other site
1205675006212	Molecular Tunnel; other site
1205675006213	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
1205675006214	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1205675006215	substrate binding site [chemical binding]; other site
1205675006216	ATP binding site [chemical binding]; other site
1205675006217	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1205675006218	Glycerate kinase family; Region: Gly_kinase; pfam02595
1205675006219	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
1205675006220	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1205675006221	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1205675006222	putative dimer interface [polypeptide binding]; other site
1205675006223	active site pocket [active]
1205675006224	putative cataytic base [active]
1205675006225	Cobalamin-5-phosphate synthase; Region: CobS; pfam02654
1205675006226	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1205675006227	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1205675006228	homodimer interface [polypeptide binding]; other site
1205675006229	substrate-cofactor binding pocket; other site
1205675006230	catalytic residue [active]
1205675006231	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1205675006232	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1205675006233	cyclase homology domain; Region: CHD; cd07302
1205675006234	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1205675006235	nucleotidyl binding site; other site
1205675006236	metal binding site [ion binding]; metal-binding site
1205675006237	dimer interface [polypeptide binding]; other site
1205675006238	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1205675006239	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1205675006240	interface (dimer of trimers) [polypeptide binding]; other site
1205675006241	Substrate-binding/catalytic site; other site
1205675006242	Zn-binding sites [ion binding]; other site
1205675006243	short chain dehydrogenase; Validated; Region: PRK05855
1205675006244	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1205675006245	classical (c) SDRs; Region: SDR_c; cd05233
1205675006246	NAD(P) binding site [chemical binding]; other site
1205675006247	active site
1205675006248	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
1205675006249	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1205675006250	E3 interaction surface; other site
1205675006251	lipoyl attachment site [posttranslational modification]; other site
1205675006252	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1205675006253	E3 interaction surface; other site
1205675006254	lipoyl attachment site [posttranslational modification]; other site
1205675006255	e3 binding domain; Region: E3_binding; pfam02817
1205675006256	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1205675006257	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1205675006258	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1205675006259	putative NAD(P) binding site [chemical binding]; other site
1205675006260	putative active site [active]
1205675006261	lipoate-protein ligase B; Provisional; Region: PRK14345
1205675006262	lipoyl synthase; Provisional; Region: PRK05481
1205675006263	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1205675006264	FeS/SAM binding site; other site
1205675006265	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
1205675006266	RDD family; Region: RDD; pfam06271
1205675006267	glutamine synthetase, type I; Region: GlnA; TIGR00653
1205675006268	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1205675006269	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1205675006270	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
1205675006271	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1205675006272	metal binding triad; other site
1205675006273	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1205675006274	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1205675006275	metal binding triad; other site
1205675006276	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1205675006277	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1205675006278	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1205675006279	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1205675006280	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1205675006281	TAP-like protein; Region: Abhydrolase_4; pfam08386
1205675006282	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1205675006283	TAP-like protein; Region: Abhydrolase_4; pfam08386
1205675006284	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1205675006285	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1205675006286	oligomerization interface [polypeptide binding]; other site
1205675006287	active site
1205675006288	metal binding site [ion binding]; metal-binding site
1205675006289	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
1205675006290	putative active site; other site
1205675006291	putative metal binding residues [ion binding]; other site
1205675006292	signature motif; other site
1205675006293	putative triphosphate binding site [ion binding]; other site
1205675006294	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
1205675006295	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826
1205675006296	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
1205675006297	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1205675006298	RNA/DNA hybrid binding site [nucleotide binding]; other site
1205675006299	active site
1205675006300	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1205675006301	catalytic core [active]
1205675006302	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
1205675006303	Putative zinc ribbon domain; Region: DUF164; pfam02591
1205675006304	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
1205675006305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1205675006306	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1205675006307	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1205675006308	hypothetical protein; Provisional; Region: PRK07908
1205675006309	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1205675006310	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675006311	homodimer interface [polypeptide binding]; other site
1205675006312	catalytic residue [active]
1205675006313	PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744
1205675006314	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1205675006315	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1205675006316	active site
1205675006317	motif I; other site
1205675006318	motif II; other site
1205675006319	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1205675006320	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1205675006321	active site
1205675006322	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1205675006323	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
1205675006324	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662
1205675006325	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1205675006326	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
1205675006327	dimer interface [polypeptide binding]; other site
1205675006328	catalytic triad [active]
1205675006329	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
1205675006330	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1205675006331	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1205675006332	dimer interface [polypeptide binding]; other site
1205675006333	TPP-binding site [chemical binding]; other site
1205675006334	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1205675006335	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1205675006336	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1205675006337	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1205675006338	acyl carrier protein; Provisional; Region: acpP; PRK00982
1205675006339	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
1205675006340	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1205675006341	dimer interface [polypeptide binding]; other site
1205675006342	active site
1205675006343	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
1205675006344	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1205675006345	dimer interface [polypeptide binding]; other site
1205675006346	active site
1205675006347	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1205675006348	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1205675006349	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1205675006350	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1205675006351	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1205675006352	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675006353	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675006354	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1205675006355	FAD binding domain; Region: FAD_binding_4; pfam01565
1205675006356	diacylglycerol kinase; Reviewed; Region: PRK11914
1205675006357	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1205675006358	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
1205675006359	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1205675006360	Beta-lactamase; Region: Beta-lactamase; pfam00144
1205675006361	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1205675006362	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675006363	S-adenosylmethionine binding site [chemical binding]; other site
1205675006364	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
1205675006365	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1205675006366	NAD binding site [chemical binding]; other site
1205675006367	catalytic Zn binding site [ion binding]; other site
1205675006368	substrate binding site [chemical binding]; other site
1205675006369	structural Zn binding site [ion binding]; other site
1205675006370	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1205675006371	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
1205675006372	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1205675006373	putative active site [active]
1205675006374	catalytic triad [active]
1205675006375	putative dimer interface [polypeptide binding]; other site
1205675006376	short chain dehydrogenase; Provisional; Region: PRK05854
1205675006377	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1205675006378	putative NAD(P) binding site [chemical binding]; other site
1205675006379	active site
1205675006380	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
1205675006381	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1205675006382	nucleotide binding site [chemical binding]; other site
1205675006383	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1205675006384	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675006385	Cytochrome P450; Region: p450; cl12078
1205675006386	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
1205675006387	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675006388	Cytochrome P450; Region: p450; cl12078
1205675006389	Septum formation; Region: Septum_form; pfam13845
1205675006390	Protein of unknown function (DUF2695); Region: DUF2695; pfam10905
1205675006391	Predicted membrane protein [Function unknown]; Region: COG2149
1205675006392	Domain of unknown function (DUF202); Region: DUF202; pfam02656
1205675006393	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675006394	Cytochrome P450; Region: p450; cl12078
1205675006395	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580
1205675006396	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1205675006397	putative active site [active]
1205675006398	catalytic site [active]
1205675006399	putative metal binding site [ion binding]; other site
1205675006400	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1205675006401	FAD binding domain; Region: FAD_binding_4; pfam01565
1205675006402	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1205675006403	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1205675006404	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1205675006405	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1205675006406	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1205675006407	dimerization interface [polypeptide binding]; other site
1205675006408	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1205675006409	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1205675006410	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1205675006411	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1205675006412	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1205675006413	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1205675006414	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1205675006415	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1205675006416	CDP-diacylglycerol pyrophosphatase [Lipid metabolism]; Region: Cdh; COG2134
1205675006417	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1205675006418	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1205675006419	active site residue [active]
1205675006420	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1205675006421	active site residue [active]
1205675006422	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
1205675006423	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1205675006424	Transposase; Region: HTH_Tnp_1; cl17663
1205675006425	Transposase; Region: HTH_Tnp_1; cl17663
1205675006426	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1205675006427	HTH-like domain; Region: HTH_21; pfam13276
1205675006428	Integrase core domain; Region: rve; pfam00665
1205675006429	Integrase core domain; Region: rve_3; pfam13683
1205675006430	HTH-like domain; Region: HTH_21; pfam13276
1205675006431	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1205675006432	Integrase core domain; Region: rve; pfam00665
1205675006433	Integrase core domain; Region: rve_3; pfam13683
1205675006434	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1205675006435	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1205675006436	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675006437	homodimer interface [polypeptide binding]; other site
1205675006438	catalytic residue [active]
1205675006439	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3196
1205675006440	haloalkane dehalogenase; Provisional; Region: PRK00870
1205675006441	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1205675006442	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1205675006443	active site
1205675006444	catalytic tetrad [active]
1205675006445	heat shock protein 90; Provisional; Region: PRK05218
1205675006446	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1205675006447	ATP binding site [chemical binding]; other site
1205675006448	Mg2+ binding site [ion binding]; other site
1205675006449	G-X-G motif; other site
1205675006450	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1205675006451	Cutinase; Region: Cutinase; pfam01083
1205675006452	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
1205675006453	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1205675006454	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
1205675006455	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1205675006456	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1205675006457	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1205675006458	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
1205675006459	Uncharacterized conserved protein [Function unknown]; Region: COG2442
1205675006460	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1205675006461	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675006462	Walker A motif; other site
1205675006463	ATP binding site [chemical binding]; other site
1205675006464	Walker B motif; other site
1205675006465	Integrase core domain; Region: rve; pfam00665
1205675006466	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675006467	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1205675006468	DNA binding site [nucleotide binding]
1205675006469	active site
1205675006470	Int/Topo IB signature motif; other site
1205675006471	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
1205675006472	DNA binding residues [nucleotide binding]
1205675006473	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
1205675006474	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1205675006475	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1205675006476	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1205675006477	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675006478	putative PBP binding loops; other site
1205675006479	ABC-ATPase subunit interface; other site
1205675006480	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1205675006481	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675006482	dimer interface [polypeptide binding]; other site
1205675006483	conserved gate region; other site
1205675006484	putative PBP binding loops; other site
1205675006485	ABC-ATPase subunit interface; other site
1205675006486	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1205675006487	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1205675006488	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1205675006489	Ligand Binding Site [chemical binding]; other site
1205675006490	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1205675006491	Ligand Binding Site [chemical binding]; other site
1205675006492	amino acid transporter; Region: 2A0306; TIGR00909
1205675006493	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1205675006494	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
1205675006495	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1205675006496	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1205675006497	catalytic residue [active]
1205675006498	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
1205675006499	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1205675006500	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1205675006501	Amidinotransferase; Region: Amidinotransf; pfam02274
1205675006502	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
1205675006503	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1205675006504	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1205675006505	putative DNA binding site [nucleotide binding]; other site
1205675006506	putative Zn2+ binding site [ion binding]; other site
1205675006507	AsnC family; Region: AsnC_trans_reg; pfam01037
1205675006508	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1205675006509	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1205675006510	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1205675006511	Walker A/P-loop; other site
1205675006512	ATP binding site [chemical binding]; other site
1205675006513	Q-loop/lid; other site
1205675006514	ABC transporter signature motif; other site
1205675006515	Walker B; other site
1205675006516	D-loop; other site
1205675006517	H-loop/switch region; other site
1205675006518	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1205675006519	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1205675006520	Walker A/P-loop; other site
1205675006521	ATP binding site [chemical binding]; other site
1205675006522	Q-loop/lid; other site
1205675006523	ABC transporter signature motif; other site
1205675006524	Walker B; other site
1205675006525	D-loop; other site
1205675006526	H-loop/switch region; other site
1205675006527	MarR family; Region: MarR; pfam01047
1205675006528	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1205675006529	PE family; Region: PE; pfam00934
1205675006530	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1205675006531	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675006532	putative substrate translocation pore; other site
1205675006533	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
1205675006534	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1205675006535	malate dehydrogenase; Provisional; Region: PRK13529
1205675006536	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1205675006537	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1205675006538	NAD(P) binding site [chemical binding]; other site
1205675006539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675006540	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1205675006541	putative substrate translocation pore; other site
1205675006542	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675006543	putative substrate translocation pore; other site
1205675006544	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1205675006545	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1205675006546	dimer interface [polypeptide binding]; other site
1205675006547	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675006548	catalytic residue [active]
1205675006549	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1205675006550	serine O-acetyltransferase; Region: cysE; TIGR01172
1205675006551	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1205675006552	trimer interface [polypeptide binding]; other site
1205675006553	active site
1205675006554	substrate binding site [chemical binding]; other site
1205675006555	CoA binding site [chemical binding]; other site
1205675006556	hypothetical protein; Provisional; Region: PRK14851
1205675006557	hypothetical protein; Validated; Region: PRK08223
1205675006558	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
1205675006559	ATP binding site [chemical binding]; other site
1205675006560	substrate interface [chemical binding]; other site
1205675006561	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1205675006562	PE family; Region: PE; pfam00934
1205675006563	DNA primase; Validated; Region: dnaG; PRK05667
1205675006564	CHC2 zinc finger; Region: zf-CHC2; cl17510
1205675006565	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1205675006566	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1205675006567	active site
1205675006568	metal binding site [ion binding]; metal-binding site
1205675006569	interdomain interaction site; other site
1205675006570	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1205675006571	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
1205675006572	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
1205675006573	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1205675006574	Zn2+ binding site [ion binding]; other site
1205675006575	Mg2+ binding site [ion binding]; other site
1205675006576	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1205675006577	Repair protein; Region: Repair_PSII; pfam04536
1205675006578	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1205675006579	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
1205675006580	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1205675006581	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
1205675006582	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1205675006583	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
1205675006584	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1205675006585	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1205675006586	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1205675006587	motif 1; other site
1205675006588	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1205675006589	active site
1205675006590	motif 2; other site
1205675006591	motif 3; other site
1205675006592	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1205675006593	anticodon binding site; other site
1205675006594	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1205675006595	dimerization interface [polypeptide binding]; other site
1205675006596	putative DNA binding site [nucleotide binding]; other site
1205675006597	putative Zn2+ binding site [ion binding]; other site
1205675006598	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1205675006599	metal binding site 2 [ion binding]; metal-binding site
1205675006600	putative DNA binding helix; other site
1205675006601	metal binding site 1 [ion binding]; metal-binding site
1205675006602	dimer interface [polypeptide binding]; other site
1205675006603	structural Zn2+ binding site [ion binding]; other site
1205675006604	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1205675006605	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1205675006606	catalytic residue [active]
1205675006607	putative FPP diphosphate  binding site; other site
1205675006608	putative FPP binding hydrophobic cleft; other site
1205675006609	dimer interface [polypeptide binding]; other site
1205675006610	putative IPP diphosphate binding site; other site
1205675006611	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1205675006612	Recombination protein O N terminal; Region: RecO_N; pfam11967
1205675006613	Recombination protein O C terminal; Region: RecO_C; pfam02565
1205675006614	amidase; Provisional; Region: PRK06061
1205675006615	Amidase; Region: Amidase; pfam01425
1205675006616	GTPase Era; Reviewed; Region: era; PRK00089
1205675006617	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1205675006618	G1 box; other site
1205675006619	GTP/Mg2+ binding site [chemical binding]; other site
1205675006620	Switch I region; other site
1205675006621	G2 box; other site
1205675006622	Switch II region; other site
1205675006623	G3 box; other site
1205675006624	G4 box; other site
1205675006625	G5 box; other site
1205675006626	KH domain; Region: KH_2; pfam07650
1205675006627	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1205675006628	Domain of unknown function DUF21; Region: DUF21; pfam01595
1205675006629	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1205675006630	Transporter associated domain; Region: CorC_HlyC; smart01091
1205675006631	metal-binding heat shock protein; Provisional; Region: PRK00016
1205675006632	K homology RNA-binding domain; Region: KH; smart00322
1205675006633	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1205675006634	PhoH-like protein; Region: PhoH; pfam02562
1205675006635	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1205675006636	PE family; Region: PE; pfam00934
1205675006637	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1205675006638	RNA methyltransferase, RsmE family; Region: TIGR00046
1205675006639	chaperone protein DnaJ; Provisional; Region: PRK14278
1205675006640	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1205675006641	HSP70 interaction site [polypeptide binding]; other site
1205675006642	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1205675006643	Zn binding sites [ion binding]; other site
1205675006644	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1205675006645	dimer interface [polypeptide binding]; other site
1205675006646	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1205675006647	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1205675006648	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
1205675006649	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1205675006650	Condensation domain; Region: Condensation; pfam00668
1205675006651	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1205675006652	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1205675006653	acyl-activating enzyme (AAE) consensus motif; other site
1205675006654	AMP binding site [chemical binding]; other site
1205675006655	Condensation domain; Region: Condensation; pfam00668
1205675006656	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1205675006657	Condensation domain; Region: Condensation; pfam00668
1205675006658	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1205675006659	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1205675006660	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1205675006661	acyl-activating enzyme (AAE) consensus motif; other site
1205675006662	AMP binding site [chemical binding]; other site
1205675006663	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1205675006664	Condensation domain; Region: Condensation; pfam00668
1205675006665	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1205675006666	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1205675006667	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675006668	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1205675006669	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1205675006670	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1205675006671	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
1205675006672	NADP binding site [chemical binding]; other site
1205675006673	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1205675006674	active site
1205675006675	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675006676	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675006677	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1205675006678	active site
1205675006679	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
1205675006680	Condensation domain; Region: Condensation; pfam00668
1205675006681	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1205675006682	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1205675006683	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1205675006684	acyl-activating enzyme (AAE) consensus motif; other site
1205675006685	AMP binding site [chemical binding]; other site
1205675006686	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1205675006687	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1205675006688	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
1205675006689	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
1205675006690	acyl-activating enzyme (AAE) consensus motif; other site
1205675006691	active site
1205675006692	AMP binding site [chemical binding]; other site
1205675006693	substrate binding site [chemical binding]; other site
1205675006694	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10419938, 12657046, 16354661, 9831524; Product type pe : putative enzyme
1205675006695	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10419938, 12657046, 16354661, 9831524; Product type pe : putative enzyme
1205675006696	salicylate synthase MbtI; Reviewed; Region: PRK07912
1205675006697	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1205675006698	Predicted permease [General function prediction only]; Region: COG3329
1205675006699	coproporphyrinogen III oxidase; Validated; Region: PRK05628
1205675006700	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1205675006701	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1205675006702	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1205675006703	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1205675006704	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1205675006705	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1205675006706	Active Sites [active]
1205675006707	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1205675006708	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1205675006709	putative active site [active]
1205675006710	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1205675006711	putative active site [active]
1205675006712	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1205675006713	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1205675006714	Predicted membrane protein [Function unknown]; Region: COG1297
1205675006715	putative oligopeptide transporter, OPT family; Region: TIGR00733
1205675006716	PE family; Region: PE; pfam00934
1205675006717	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1205675006718	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
1205675006719	Walker A/P-loop; other site
1205675006720	ATP binding site [chemical binding]; other site
1205675006721	Q-loop/lid; other site
1205675006722	ABC transporter signature motif; other site
1205675006723	Walker B; other site
1205675006724	D-loop; other site
1205675006725	H-loop/switch region; other site
1205675006726	sulfate transport protein; Provisional; Region: cysT; CHL00187
1205675006727	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675006728	dimer interface [polypeptide binding]; other site
1205675006729	conserved gate region; other site
1205675006730	putative PBP binding loops; other site
1205675006731	ABC-ATPase subunit interface; other site
1205675006732	sulfate transport protein; Provisional; Region: cysT; CHL00187
1205675006733	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675006734	dimer interface [polypeptide binding]; other site
1205675006735	conserved gate region; other site
1205675006736	putative PBP binding loops; other site
1205675006737	ABC-ATPase subunit interface; other site
1205675006738	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
1205675006739	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1205675006740	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1205675006741	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1205675006742	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1205675006743	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1205675006744	PknH-like extracellular domain; Region: PknH_C; pfam14032
1205675006745	GTP-binding protein LepA; Provisional; Region: PRK05433
1205675006746	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1205675006747	G1 box; other site
1205675006748	putative GEF interaction site [polypeptide binding]; other site
1205675006749	GTP/Mg2+ binding site [chemical binding]; other site
1205675006750	Switch I region; other site
1205675006751	G2 box; other site
1205675006752	G3 box; other site
1205675006753	Switch II region; other site
1205675006754	G4 box; other site
1205675006755	G5 box; other site
1205675006756	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1205675006757	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1205675006758	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1205675006759	PemK-like protein; Region: PemK; pfam02452
1205675006760	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
1205675006761	FOG: CBS domain [General function prediction only]; Region: COG0517
1205675006762	ribonuclease Z; Reviewed; Region: PRK00055
1205675006763	PE family; Region: PE; pfam00934
1205675006764	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1205675006765	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1205675006766	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1205675006767	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1205675006768	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1205675006769	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1205675006770	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1205675006771	hypothetical protein; Reviewed; Region: PRK07914
1205675006772	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1205675006773	Competence protein; Region: Competence; pfam03772
1205675006774	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1205675006775	Helix-hairpin-helix motif; Region: HHH; pfam00633
1205675006776	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
1205675006777	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1205675006778	Coenzyme A binding pocket [chemical binding]; other site
1205675006779	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
1205675006780	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1205675006781	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1205675006782	active site
1205675006783	catalytic triad [active]
1205675006784	oxyanion hole [active]
1205675006785	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1205675006786	catalytic core [active]
1205675006787	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1205675006788	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1205675006789	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1205675006790	active site
1205675006791	(T/H)XGH motif; other site
1205675006792	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675006793	S-adenosylmethionine binding site [chemical binding]; other site
1205675006794	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1205675006795	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1205675006796	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1205675006797	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
1205675006798	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1205675006799	metal ion-dependent adhesion site (MIDAS); other site
1205675006800	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1205675006801	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675006802	Walker A motif; other site
1205675006803	ATP binding site [chemical binding]; other site
1205675006804	Walker B motif; other site
1205675006805	arginine finger; other site
1205675006806	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1205675006807	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1205675006808	putative catalytic cysteine [active]
1205675006809	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1205675006810	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1205675006811	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1205675006812	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1205675006813	dimer interface [polypeptide binding]; other site
1205675006814	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1205675006815	catalytic triad [active]
1205675006816	peroxidatic and resolving cysteines [active]
1205675006817	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
1205675006818	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
1205675006819	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675006820	PPE family; Region: PPE; pfam00823
1205675006821	PE family; Region: PE; pfam00934
1205675006822	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1205675006823	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1205675006824	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1205675006825	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1205675006826	ligand binding site [chemical binding]; other site
1205675006827	flexible hinge region; other site
1205675006828	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1205675006829	dimerization interface [polypeptide binding]; other site
1205675006830	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
1205675006831	cyclase homology domain; Region: CHD; cd07302
1205675006832	nucleotidyl binding site; other site
1205675006833	metal binding site [ion binding]; metal-binding site
1205675006834	dimer interface [polypeptide binding]; other site
1205675006835	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1205675006836	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1205675006837	substrate binding site [chemical binding]; other site
1205675006838	dimer interface [polypeptide binding]; other site
1205675006839	ATP binding site [chemical binding]; other site
1205675006840	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1205675006841	NAD synthetase; Reviewed; Region: nadE; PRK02628
1205675006842	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
1205675006843	multimer interface [polypeptide binding]; other site
1205675006844	active site
1205675006845	catalytic triad [active]
1205675006846	protein interface 1 [polypeptide binding]; other site
1205675006847	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1205675006848	homodimer interface [polypeptide binding]; other site
1205675006849	NAD binding pocket [chemical binding]; other site
1205675006850	ATP binding pocket [chemical binding]; other site
1205675006851	Mg binding site [ion binding]; other site
1205675006852	active-site loop [active]
1205675006853	gamma-glutamyl kinase; Provisional; Region: PRK05429
1205675006854	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1205675006855	nucleotide binding site [chemical binding]; other site
1205675006856	homotetrameric interface [polypeptide binding]; other site
1205675006857	putative phosphate binding site [ion binding]; other site
1205675006858	putative allosteric binding site; other site
1205675006859	PUA domain; Region: PUA; pfam01472
1205675006860	GTPase CgtA; Reviewed; Region: obgE; PRK12296
1205675006861	GTP1/OBG; Region: GTP1_OBG; pfam01018
1205675006862	Obg GTPase; Region: Obg; cd01898
1205675006863	G1 box; other site
1205675006864	GTP/Mg2+ binding site [chemical binding]; other site
1205675006865	Switch I region; other site
1205675006866	G2 box; other site
1205675006867	G3 box; other site
1205675006868	Switch II region; other site
1205675006869	G4 box; other site
1205675006870	G5 box; other site
1205675006871	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1205675006872	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1205675006873	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1205675006874	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1205675006875	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1205675006876	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1205675006877	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1205675006878	homodimer interface [polypeptide binding]; other site
1205675006879	oligonucleotide binding site [chemical binding]; other site
1205675006880	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1205675006881	active site
1205675006882	multimer interface [polypeptide binding]; other site
1205675006883	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
1205675006884	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1205675006885	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1205675006886	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1205675006887	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1205675006888	active site
1205675006889	HIGH motif; other site
1205675006890	nucleotide binding site [chemical binding]; other site
1205675006891	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1205675006892	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1205675006893	active site
1205675006894	KMSKS motif; other site
1205675006895	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1205675006896	tRNA binding surface [nucleotide binding]; other site
1205675006897	anticodon binding site; other site
1205675006898	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1205675006899	Uncharacterized conserved protein [Function unknown]; Region: COG3268
1205675006900	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1205675006901	NAD(P) binding pocket [chemical binding]; other site
1205675006902	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1205675006903	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1205675006904	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1205675006905	GTP binding site; other site
1205675006906	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
1205675006907	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1205675006908	TPP-binding site [chemical binding]; other site
1205675006909	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1205675006910	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
1205675006911	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1205675006912	dimer interface [polypeptide binding]; other site
1205675006913	PYR/PP interface [polypeptide binding]; other site
1205675006914	TPP binding site [chemical binding]; other site
1205675006915	substrate binding site [chemical binding]; other site
1205675006916	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1205675006917	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1205675006918	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675006919	Walker A motif; other site
1205675006920	ATP binding site [chemical binding]; other site
1205675006921	Walker B motif; other site
1205675006922	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1205675006923	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
1205675006924	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1205675006925	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675006926	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1205675006927	putative substrate translocation pore; other site
1205675006928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675006929	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
1205675006930	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1205675006931	oligomer interface [polypeptide binding]; other site
1205675006932	active site residues [active]
1205675006933	Clp protease; Region: CLP_protease; pfam00574
1205675006934	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1205675006935	oligomer interface [polypeptide binding]; other site
1205675006936	active site residues [active]
1205675006937	trigger factor; Provisional; Region: tig; PRK01490
1205675006938	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1205675006939	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1205675006940	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1205675006941	Beta-lactamase; Region: Beta-lactamase; pfam00144
1205675006942	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1205675006943	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
1205675006944	putative DNA binding site [nucleotide binding]; other site
1205675006945	catalytic residue [active]
1205675006946	putative H2TH interface [polypeptide binding]; other site
1205675006947	putative catalytic residues [active]
1205675006948	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1205675006949	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1205675006950	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1205675006951	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1205675006952	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1205675006953	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
1205675006954	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
1205675006955	Zn binding site [ion binding]; other site
1205675006956	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1205675006957	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675006958	active site
1205675006959	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1205675006960	apolar tunnel; other site
1205675006961	heme binding site [chemical binding]; other site
1205675006962	dimerization interface [polypeptide binding]; other site
1205675006963	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
1205675006964	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1205675006965	active site
1205675006966	catalytic site [active]
1205675006967	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1205675006968	active site
1205675006969	NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902
1205675006970	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1205675006971	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1205675006972	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1205675006973	ABC transporter; Region: ABC_tran_2; pfam12848
1205675006974	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1205675006975	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1205675006976	dimer interface [polypeptide binding]; other site
1205675006977	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1205675006978	ssDNA binding site [nucleotide binding]; other site
1205675006979	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1205675006980	glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355
1205675006981	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
1205675006982	putative acyl-acceptor binding pocket; other site
1205675006983	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1205675006984	HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1
1205675006985	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1205675006986	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1205675006987	putative acyl-acceptor binding pocket; other site
1205675006988	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1205675006989	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1205675006990	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1205675006991	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1205675006992	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1205675006993	enoyl-CoA hydratase; Provisional; Region: PRK05870
1205675006994	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675006995	substrate binding site [chemical binding]; other site
1205675006996	oxyanion hole (OAH) forming residues; other site
1205675006997	trimer interface [polypeptide binding]; other site
1205675006998	PE family; Region: PE; pfam00934
1205675006999	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1205675007000	cyclase homology domain; Region: CHD; cd07302
1205675007001	nucleotidyl binding site; other site
1205675007002	metal binding site [ion binding]; metal-binding site
1205675007003	dimer interface [polypeptide binding]; other site
1205675007004	Predicted ATPase [General function prediction only]; Region: COG3903
1205675007005	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1205675007006	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1205675007007	DNA binding residues [nucleotide binding]
1205675007008	dimerization interface [polypeptide binding]; other site
1205675007009	PE family; Region: PE; pfam00934
1205675007010	TIGR00725 family protein; Region: TIGR00725
1205675007011	thymidylate synthase; Provisional; Region: thyA; PRK00956
1205675007012	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1205675007013	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1205675007014	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1205675007015	E3 interaction surface; other site
1205675007016	lipoyl attachment site [posttranslational modification]; other site
1205675007017	e3 binding domain; Region: E3_binding; pfam02817
1205675007018	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1205675007019	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1205675007020	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1205675007021	alpha subunit interface [polypeptide binding]; other site
1205675007022	TPP binding site [chemical binding]; other site
1205675007023	heterodimer interface [polypeptide binding]; other site
1205675007024	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1205675007025	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1205675007026	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1205675007027	tetramer interface [polypeptide binding]; other site
1205675007028	TPP-binding site [chemical binding]; other site
1205675007029	heterodimer interface [polypeptide binding]; other site
1205675007030	phosphorylation loop region [posttranslational modification]
1205675007031	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1205675007032	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1205675007033	putative active site [active]
1205675007034	putative catalytic site [active]
1205675007035	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675007036	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675007037	active site
1205675007038	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1205675007039	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1205675007040	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1205675007041	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1205675007042	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1205675007043	carboxyltransferase (CT) interaction site; other site
1205675007044	biotinylation site [posttranslational modification]; other site
1205675007045	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1205675007046	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1205675007047	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1205675007048	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1205675007049	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1205675007050	AMP-binding domain protein; Validated; Region: PRK08315
1205675007051	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675007052	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1205675007053	acyl-activating enzyme (AAE) consensus motif; other site
1205675007054	acyl-activating enzyme (AAE) consensus motif; other site
1205675007055	putative AMP binding site [chemical binding]; other site
1205675007056	putative active site [active]
1205675007057	putative CoA binding site [chemical binding]; other site
1205675007058	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675007059	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675007060	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
1205675007061	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1205675007062	classical (c) SDRs; Region: SDR_c; cd05233
1205675007063	NAD(P) binding site [chemical binding]; other site
1205675007064	active site
1205675007065	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1205675007066	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1205675007067	catalytic site [active]
1205675007068	putative active site [active]
1205675007069	putative substrate binding site [chemical binding]; other site
1205675007070	dimer interface [polypeptide binding]; other site
1205675007071	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
1205675007072	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1205675007073	non-specific DNA binding site [nucleotide binding]; other site
1205675007074	salt bridge; other site
1205675007075	sequence-specific DNA binding site [nucleotide binding]; other site
1205675007076	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
1205675007077	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893
1205675007078	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1205675007079	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
1205675007080	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1205675007081	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1205675007082	PE family; Region: PE; pfam00934
1205675007083	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
1205675007084	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1205675007085	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1205675007086	catalytic triad [active]
1205675007087	hypothetical protein; Provisional; Region: PRK07907
1205675007088	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
1205675007089	active site
1205675007090	metal binding site [ion binding]; metal-binding site
1205675007091	dimer interface [polypeptide binding]; other site
1205675007092	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1205675007093	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1205675007094	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
1205675007095	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1205675007096	phosphate binding site [ion binding]; other site
1205675007097	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
1205675007098	FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit.  Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447
1205675007099	putative active site [active]
1205675007100	putative catalytic site [active]
1205675007101	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1205675007102	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1205675007103	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
1205675007104	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
1205675007105	putative NAD(P) binding site [chemical binding]; other site
1205675007106	active site
1205675007107	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
1205675007108	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1205675007109	active site
1205675007110	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
1205675007111	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1205675007112	putative active site [active]
1205675007113	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
1205675007114	Mrr N-terminal domain; Region: Mrr_N; pfam14338
1205675007115	Restriction endonuclease; Region: Mrr_cat; pfam04471
1205675007116	ERCC4 domain; Region: ERCC4; pfam02732
1205675007117	Lsr2; Region: Lsr2; pfam11774
1205675007118	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1205675007119	putative active site [active]
1205675007120	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1205675007121	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1205675007122	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1205675007123	catalytic residue [active]
1205675007124	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1205675007125	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1205675007126	putative RNA binding site [nucleotide binding]; other site
1205675007127	elongation factor P; Validated; Region: PRK00529
1205675007128	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1205675007129	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1205675007130	RNA binding site [nucleotide binding]; other site
1205675007131	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1205675007132	RNA binding site [nucleotide binding]; other site
1205675007133	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1205675007134	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1205675007135	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1205675007136	active site
1205675007137	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1205675007138	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1205675007139	trimer interface [polypeptide binding]; other site
1205675007140	active site
1205675007141	dimer interface [polypeptide binding]; other site
1205675007142	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1205675007143	active site
1205675007144	dimer interface [polypeptide binding]; other site
1205675007145	metal binding site [ion binding]; metal-binding site
1205675007146	shikimate kinase; Reviewed; Region: aroK; PRK00131
1205675007147	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1205675007148	ADP binding site [chemical binding]; other site
1205675007149	magnesium binding site [ion binding]; other site
1205675007150	putative shikimate binding site; other site
1205675007151	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1205675007152	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1205675007153	Tetramer interface [polypeptide binding]; other site
1205675007154	active site
1205675007155	FMN-binding site [chemical binding]; other site
1205675007156	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
1205675007157	digalactosyldiacylglycerol synthase; Region: PLN02846
1205675007158	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1205675007159	putative active site [active]
1205675007160	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1205675007161	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1205675007162	oligomeric interface; other site
1205675007163	putative active site [active]
1205675007164	homodimer interface [polypeptide binding]; other site
1205675007165	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
1205675007166	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1205675007167	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1205675007168	shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809
1205675007169	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1205675007170	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1205675007171	NAD(P) binding site [chemical binding]; other site
1205675007172	shikimate binding site; other site
1205675007173	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
1205675007174	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1205675007175	dimerization interface [polypeptide binding]; other site
1205675007176	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1205675007177	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1205675007178	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1205675007179	motif 1; other site
1205675007180	active site
1205675007181	motif 2; other site
1205675007182	motif 3; other site
1205675007183	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1205675007184	DHHA1 domain; Region: DHHA1; pfam02272
1205675007185	Uncharacterized conserved protein [Function unknown]; Region: COG0432
1205675007186	recombination factor protein RarA; Reviewed; Region: PRK13342
1205675007187	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675007188	Walker A motif; other site
1205675007189	ATP binding site [chemical binding]; other site
1205675007190	Walker B motif; other site
1205675007191	arginine finger; other site
1205675007192	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1205675007193	Predicted integral membrane protein [Function unknown]; Region: COG5473
1205675007194	Protein of unknown function (DUF2652); Region: DUF2652; pfam10851
1205675007195	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1205675007196	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1205675007197	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1205675007198	Walker A/P-loop; other site
1205675007199	ATP binding site [chemical binding]; other site
1205675007200	Q-loop/lid; other site
1205675007201	ABC transporter signature motif; other site
1205675007202	Walker B; other site
1205675007203	D-loop; other site
1205675007204	H-loop/switch region; other site
1205675007205	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1205675007206	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1205675007207	ligand binding site [chemical binding]; other site
1205675007208	flexible hinge region; other site
1205675007209	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1205675007210	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1205675007211	ligand binding site [chemical binding]; other site
1205675007212	flexible hinge region; other site
1205675007213	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1205675007214	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
1205675007215	active site
1205675007216	nucleophile elbow; other site
1205675007217	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1205675007218	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1205675007219	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1205675007220	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
1205675007221	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
1205675007222	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1205675007223	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1205675007224	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1205675007225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
1205675007226	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
1205675007227	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1205675007228	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1205675007229	Transglutaminase/protease-like homologues; Region: TGc; smart00460
1205675007230	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3801
1205675007231	Predicted membrane protein [Function unknown]; Region: COG4129
1205675007232	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1205675007233	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1205675007234	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1205675007235	dimer interface [polypeptide binding]; other site
1205675007236	anticodon binding site; other site
1205675007237	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1205675007238	homodimer interface [polypeptide binding]; other site
1205675007239	motif 1; other site
1205675007240	active site
1205675007241	motif 2; other site
1205675007242	GAD domain; Region: GAD; pfam02938
1205675007243	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1205675007244	active site
1205675007245	motif 3; other site
1205675007246	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1205675007247	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1205675007248	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1205675007249	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1205675007250	putative hydrophobic ligand binding site [chemical binding]; other site
1205675007251	protein interface [polypeptide binding]; other site
1205675007252	gate; other site
1205675007253	Predicted metalloprotease [General function prediction only]; Region: COG2321
1205675007254	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1205675007255	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1205675007256	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1205675007257	active site
1205675007258	metal binding site [ion binding]; metal-binding site
1205675007259	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1205675007260	haloalkane dehalogenase; Provisional; Region: PRK03592
1205675007261	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1205675007262	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1205675007263	dimer interface [polypeptide binding]; other site
1205675007264	motif 1; other site
1205675007265	active site
1205675007266	motif 2; other site
1205675007267	motif 3; other site
1205675007268	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1205675007269	anticodon binding site; other site
1205675007270	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1205675007271	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1205675007272	active site
1205675007273	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
1205675007274	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1205675007275	Zn2+ binding site [ion binding]; other site
1205675007276	Mg2+ binding site [ion binding]; other site
1205675007277	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1205675007278	synthetase active site [active]
1205675007279	NTP binding site [chemical binding]; other site
1205675007280	metal binding site [ion binding]; metal-binding site
1205675007281	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1205675007282	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1205675007283	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1205675007284	active site
1205675007285	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1205675007286	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1205675007287	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1205675007288	Protein export membrane protein; Region: SecD_SecF; pfam02355
1205675007289	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1205675007290	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1205675007291	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886
1205675007292	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
1205675007293	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1205675007294	inhibitor-cofactor binding pocket; inhibition site
1205675007295	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675007296	catalytic residue [active]
1205675007297	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1205675007298	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675007299	acyl-activating enzyme (AAE) consensus motif; other site
1205675007300	AMP binding site [chemical binding]; other site
1205675007301	active site
1205675007302	CoA binding site [chemical binding]; other site
1205675007303	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
1205675007304	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1205675007305	putative NAD(P) binding site [chemical binding]; other site
1205675007306	active site
1205675007307	putative substrate binding site [chemical binding]; other site
1205675007308	PE family; Region: PE; pfam00934
1205675007309	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1205675007310	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675007311	Walker A motif; other site
1205675007312	ATP binding site [chemical binding]; other site
1205675007313	Walker B motif; other site
1205675007314	arginine finger; other site
1205675007315	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1205675007316	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1205675007317	RuvA N terminal domain; Region: RuvA_N; pfam01330
1205675007318	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1205675007319	active site
1205675007320	putative DNA-binding cleft [nucleotide binding]; other site
1205675007321	dimer interface [polypeptide binding]; other site
1205675007322	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1205675007323	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
1205675007324	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1205675007325	putative active site [active]
1205675007326	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
1205675007327	Protein of unknown function DUF2617; Region: DUF2617; pfam10936
1205675007328	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
1205675007329	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1205675007330	Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262
1205675007331	Spermine/spermidine synthase; Region: Spermine_synth; pfam01564
1205675007332	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
1205675007333	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1205675007334	hypothetical protein; Validated; Region: PRK00110
1205675007335	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1205675007336	predicted active site [active]
1205675007337	catalytic triad [active]
1205675007338	acyl-CoA thioesterase II; Region: tesB; TIGR00189
1205675007339	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1205675007340	active site
1205675007341	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1205675007342	catalytic triad [active]
1205675007343	dimer interface [polypeptide binding]; other site
1205675007344	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1205675007345	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1205675007346	active site
1205675007347	multimer interface [polypeptide binding]; other site
1205675007348	Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259
1205675007349	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1205675007350	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1205675007351	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675007352	PPE family; Region: PPE; pfam00823
1205675007353	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675007354	PE-PPE domain; Region: PE-PPE; pfam08237
1205675007355	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
1205675007356	nudix motif; other site
1205675007357	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1205675007358	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1205675007359	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1205675007360	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1205675007361	putative acyl-acceptor binding pocket; other site
1205675007362	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1205675007363	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
1205675007364	nucleotide binding site/active site [active]
1205675007365	HIT family signature motif; other site
1205675007366	catalytic residue [active]
1205675007367	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
1205675007368	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1205675007369	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1205675007370	active site
1205675007371	dimer interface [polypeptide binding]; other site
1205675007372	motif 1; other site
1205675007373	motif 2; other site
1205675007374	motif 3; other site
1205675007375	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1205675007376	anticodon binding site; other site
1205675007377	PE family; Region: PE; pfam00934
1205675007378	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4762
1205675007379	Predicted transcriptional regulator [Transcription]; Region: COG2345
1205675007380	Helix-turn-helix domain; Region: HTH_20; pfam12840
1205675007381	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1205675007382	Predicted transcriptional regulator [Transcription]; Region: COG2345
1205675007383	Helix-turn-helix domain; Region: HTH_20; pfam12840
1205675007384	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675007385	S-adenosylmethionine binding site [chemical binding]; other site
1205675007386	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1205675007387	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1205675007388	Ligand Binding Site [chemical binding]; other site
1205675007389	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1205675007390	Ligand Binding Site [chemical binding]; other site
1205675007391	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1205675007392	Ligand Binding Site [chemical binding]; other site
1205675007393	Universal stress protein family; Region: Usp; pfam00582
1205675007394	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
1205675007395	active site
1205675007396	Peptidase family M50; Region: Peptidase_M50; pfam02163
1205675007397	putative substrate binding region [chemical binding]; other site
1205675007398	FOG: CBS domain [General function prediction only]; Region: COG0517
1205675007399	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
1205675007400	FOG: CBS domain [General function prediction only]; Region: COG0517
1205675007401	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1205675007402	peptide chain release factor 1; Provisional; Region: PRK04011
1205675007403	SHS2 domain protein implicated in nucleic acid metabolism [General function prediction    only]; Region: COG1371
1205675007404	Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690
1205675007405	hypothetical protein; Reviewed; Region: PRK09588
1205675007406	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
1205675007407	Hemerythrin-like domain; Region: Hr-like; cd12108
1205675007408	Fe binding site [ion binding]; other site
1205675007409	PE family; Region: PE; pfam00934
1205675007410	Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cd00227
1205675007411	P-loop motif; other site
1205675007412	ATP binding site [chemical binding]; other site
1205675007413	Chloramphenicol (Cm) binding site [chemical binding]; other site
1205675007414	catalytic residue [active]
1205675007415	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1205675007416	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1205675007417	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1205675007418	anti sigma factor interaction site; other site
1205675007419	regulatory phosphorylation site [posttranslational modification]; other site
1205675007420	hypothetical protein; Provisional; Region: PRK02237
1205675007421	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1205675007422	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1205675007423	putative DNA binding site [nucleotide binding]; other site
1205675007424	putative Zn2+ binding site [ion binding]; other site
1205675007425	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
1205675007426	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1205675007427	putative metal binding site [ion binding]; other site
1205675007428	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1205675007429	dimerization interface [polypeptide binding]; other site
1205675007430	putative DNA binding site [nucleotide binding]; other site
1205675007431	putative Zn2+ binding site [ion binding]; other site
1205675007432	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1205675007433	arsenical-resistance protein; Region: acr3; TIGR00832
1205675007434	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1205675007435	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1205675007436	active site
1205675007437	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1205675007438	MULE transposase domain; Region: MULE; pfam10551
1205675007439	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1205675007440	Clp amino terminal domain; Region: Clp_N; pfam02861
1205675007441	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1205675007442	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1205675007443	Coenzyme A binding pocket [chemical binding]; other site
1205675007444	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
1205675007445	hypothetical protein; Provisional; Region: PRK14059
1205675007446	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
1205675007447	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675007448	TAP-like protein; Region: Abhydrolase_4; pfam08386
1205675007449	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1205675007450	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
1205675007451	SelR domain; Region: SelR; pfam01641
1205675007452	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1205675007453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675007454	S-adenosylmethionine binding site [chemical binding]; other site
1205675007455	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
1205675007456	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1205675007457	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1205675007458	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1205675007459	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1205675007460	substrate binding site [chemical binding]; other site
1205675007461	active site
1205675007462	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675007463	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1205675007464	substrate binding site [chemical binding]; other site
1205675007465	oxyanion hole (OAH) forming residues; other site
1205675007466	trimer interface [polypeptide binding]; other site
1205675007467	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
1205675007468	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1205675007469	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1205675007470	catalytic site [active]
1205675007471	putative active site [active]
1205675007472	putative substrate binding site [chemical binding]; other site
1205675007473	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
1205675007474	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1205675007475	TPP-binding site; other site
1205675007476	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1205675007477	PYR/PP interface [polypeptide binding]; other site
1205675007478	dimer interface [polypeptide binding]; other site
1205675007479	TPP binding site [chemical binding]; other site
1205675007480	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1205675007481	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1205675007482	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1205675007483	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1205675007484	transmembrane helices; other site
1205675007485	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1205675007486	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1205675007487	transmembrane helices; other site
1205675007488	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1205675007489	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1205675007490	Walker A/P-loop; other site
1205675007491	ATP binding site [chemical binding]; other site
1205675007492	Q-loop/lid; other site
1205675007493	ABC transporter signature motif; other site
1205675007494	Walker B; other site
1205675007495	D-loop; other site
1205675007496	H-loop/switch region; other site
1205675007497	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1205675007498	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1205675007499	TrkA-N domain; Region: TrkA_N; pfam02254
1205675007500	TrkA-C domain; Region: TrkA_C; pfam02080
1205675007501	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1205675007502	TrkA-N domain; Region: TrkA_N; pfam02254
1205675007503	TrkA-C domain; Region: TrkA_C; pfam02080
1205675007504	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
1205675007505	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1205675007506	generic binding surface II; other site
1205675007507	ssDNA binding site; other site
1205675007508	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
1205675007509	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1205675007510	trimer interface [polypeptide binding]; other site
1205675007511	active site
1205675007512	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
1205675007513	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
1205675007514	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1205675007515	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1205675007516	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1205675007517	active site
1205675007518	dimerization interface [polypeptide binding]; other site
1205675007519	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1205675007520	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1205675007521	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1205675007522	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1205675007523	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1205675007524	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1205675007525	DNA binding residues [nucleotide binding]
1205675007526	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
1205675007527	homotrimer interaction site [polypeptide binding]; other site
1205675007528	putative active site [active]
1205675007529	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
1205675007530	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
1205675007531	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
1205675007532	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
1205675007533	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1205675007534	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1205675007535	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1205675007536	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1205675007537	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1205675007538	DNA binding residues [nucleotide binding]
1205675007539	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1205675007540	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1205675007541	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1205675007542	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
1205675007543	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
1205675007544	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
1205675007545	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1205675007546	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1205675007547	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1205675007548	PAC2 family; Region: PAC2; pfam09754
1205675007549	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675007550	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1205675007551	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1205675007552	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme
1205675007553	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1205675007554	MULE transposase domain; Region: MULE; pfam10551
1205675007555	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pe : putative enzyme
1205675007556	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1205675007557	ATP cone domain; Region: ATP-cone; pfam03477
1205675007558	LysM domain; Region: LysM; pfam01476
1205675007559	LexA repressor; Validated; Region: PRK00215
1205675007560	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1205675007561	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1205675007562	Catalytic site [active]
1205675007563	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1205675007564	LGFP repeat; Region: LGFP; pfam08310
1205675007565	LGFP repeat; Region: LGFP; pfam08310
1205675007566	LGFP repeat; Region: LGFP; pfam08310
1205675007567	LGFP repeat; Region: LGFP; pfam08310
1205675007568	LGFP repeat; Region: LGFP; pfam08310
1205675007569	Integral membrane protein TerC family; Region: TerC; cl10468
1205675007570	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675007571	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675007572	active site
1205675007573	GTPases [General function prediction only]; Region: HflX; COG2262
1205675007574	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1205675007575	HflX GTPase family; Region: HflX; cd01878
1205675007576	G1 box; other site
1205675007577	GTP/Mg2+ binding site [chemical binding]; other site
1205675007578	Switch I region; other site
1205675007579	G2 box; other site
1205675007580	G3 box; other site
1205675007581	Switch II region; other site
1205675007582	G4 box; other site
1205675007583	G5 box; other site
1205675007584	diaminopimelate epimerase; Region: DapF; TIGR00652
1205675007585	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1205675007586	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1205675007587	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1205675007588	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1205675007589	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
1205675007590	active site
1205675007591	metal binding site [ion binding]; metal-binding site
1205675007592	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1205675007593	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1205675007594	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1205675007595	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
1205675007596	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1205675007597	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1205675007598	FeS/SAM binding site; other site
1205675007599	TRAM domain; Region: TRAM; cl01282
1205675007600	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1205675007601	FeS/SAM binding site; other site
1205675007602	Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137
1205675007603	DNA recombination protein RecA; Reviewed; Region: recA; PRK09519
1205675007604	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1205675007605	hexamer interface [polypeptide binding]; other site
1205675007606	Walker A motif; other site
1205675007607	ATP binding site [chemical binding]; other site
1205675007608	Walker B motif; other site
1205675007609	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1205675007610	protein-splicing catalytic site; other site
1205675007611	thioester formation/cholesterol transfer; other site
1205675007612	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
1205675007613	recA bacterial DNA recombination protein; Region: RecA; cl17211
1205675007614	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1205675007615	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
1205675007616	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1205675007617	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1205675007618	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1205675007619	PE family; Region: PE; pfam00934
1205675007620	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
1205675007621	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1205675007622	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1205675007623	non-specific DNA binding site [nucleotide binding]; other site
1205675007624	salt bridge; other site
1205675007625	sequence-specific DNA binding site [nucleotide binding]; other site
1205675007626	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1205675007627	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1205675007628	Coenzyme A binding pocket [chemical binding]; other site
1205675007629	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1205675007630	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1205675007631	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1205675007632	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1205675007633	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
1205675007634	classical (c) SDRs; Region: SDR_c; cd05233
1205675007635	NAD(P) binding site [chemical binding]; other site
1205675007636	active site
1205675007637	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675007638	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1205675007639	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1205675007640	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1205675007641	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1205675007642	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1205675007643	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1205675007644	dimer interface [polypeptide binding]; other site
1205675007645	active site
1205675007646	catalytic residue [active]
1205675007647	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
1205675007648	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
1205675007649	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
1205675007650	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1205675007651	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1205675007652	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1205675007653	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1205675007654	putative active site [active]
1205675007655	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
1205675007656	PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871
1205675007657	putative active site [active]
1205675007658	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
1205675007659	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1205675007660	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1205675007661	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
1205675007662	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1205675007663	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1205675007664	folate binding site [chemical binding]; other site
1205675007665	NADP+ binding site [chemical binding]; other site
1205675007666	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1205675007667	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1205675007668	dimerization interface [polypeptide binding]; other site
1205675007669	active site
1205675007670	Dienelactone hydrolase family; Region: DLH; pfam01738
1205675007671	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
1205675007672	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1205675007673	classical (c) SDRs; Region: SDR_c; cd05233
1205675007674	NAD(P) binding site [chemical binding]; other site
1205675007675	active site
1205675007676	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675007677	PPE family; Region: PPE; pfam00823
1205675007678	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675007679	PE family; Region: PE; pfam00934
1205675007680	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675007681	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675007682	PPE family; Region: PPE; pfam00823
1205675007683	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1205675007684	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1205675007685	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1205675007686	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1205675007687	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1205675007688	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1205675007689	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1205675007690	Coenzyme A binding pocket [chemical binding]; other site
1205675007691	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1205675007692	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1205675007693	FMN-binding pocket [chemical binding]; other site
1205675007694	flavin binding motif; other site
1205675007695	phosphate binding motif [ion binding]; other site
1205675007696	beta-alpha-beta structure motif; other site
1205675007697	NAD binding pocket [chemical binding]; other site
1205675007698	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1205675007699	catalytic loop [active]
1205675007700	iron binding site [ion binding]; other site
1205675007701	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1205675007702	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
1205675007703	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1205675007704	hydrophobic ligand binding site; other site
1205675007705	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1205675007706	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1205675007707	putative DNA binding site [nucleotide binding]; other site
1205675007708	putative Zn2+ binding site [ion binding]; other site
1205675007709	AsnC family; Region: AsnC_trans_reg; pfam01037
1205675007710	alanine dehydrogenase; Region: alaDH; TIGR00518
1205675007711	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1205675007712	hexamer interface [polypeptide binding]; other site
1205675007713	ligand binding site [chemical binding]; other site
1205675007714	putative active site [active]
1205675007715	NAD(P) binding site [chemical binding]; other site
1205675007716	Nitronate monooxygenase; Region: NMO; pfam03060
1205675007717	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1205675007718	FMN binding site [chemical binding]; other site
1205675007719	substrate binding site [chemical binding]; other site
1205675007720	putative catalytic residue [active]
1205675007721	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1205675007722	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1205675007723	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1205675007724	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
1205675007725	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
1205675007726	oligomer interface [polypeptide binding]; other site
1205675007727	RNA binding site [nucleotide binding]; other site
1205675007728	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1205675007729	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1205675007730	RNase E interface [polypeptide binding]; other site
1205675007731	trimer interface [polypeptide binding]; other site
1205675007732	active site
1205675007733	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1205675007734	putative nucleic acid binding region [nucleotide binding]; other site
1205675007735	G-X-X-G motif; other site
1205675007736	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1205675007737	RNA binding site [nucleotide binding]; other site
1205675007738	domain interface; other site
1205675007739	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1205675007740	16S/18S rRNA binding site [nucleotide binding]; other site
1205675007741	S13e-L30e interaction site [polypeptide binding]; other site
1205675007742	25S rRNA binding site [nucleotide binding]; other site
1205675007743	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1205675007744	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1205675007745	active site
1205675007746	Riboflavin kinase; Region: Flavokinase; pfam01687
1205675007747	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1205675007748	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1205675007749	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1205675007750	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1205675007751	putative DNA binding site [nucleotide binding]; other site
1205675007752	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1205675007753	FeoA domain; Region: FeoA; pfam04023
1205675007754	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675007755	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675007756	active site
1205675007757	lipid-transfer protein; Provisional; Region: PRK08256
1205675007758	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1205675007759	active site
1205675007760	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
1205675007761	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1205675007762	RNA binding site [nucleotide binding]; other site
1205675007763	active site
1205675007764	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
1205675007765	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
1205675007766	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1205675007767	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1205675007768	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1205675007769	active site
1205675007770	metal binding site [ion binding]; metal-binding site
1205675007771	Uncharacterized conserved protein [Function unknown]; Region: COG4717
1205675007772	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
1205675007773	nucleophilic elbow; other site
1205675007774	catalytic triad; other site
1205675007775	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1205675007776	Predicted acyl esterases [General function prediction only]; Region: COG2936
1205675007777	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
1205675007778	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
1205675007779	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
1205675007780	Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373
1205675007781	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
1205675007782	Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046, 15024109
1205675007783	Predicted ATPase [General function prediction only]; Region: COG3903
1205675007784	Predicted ATPase [General function prediction only]; Region: COG3903
1205675007785	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1205675007786	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1205675007787	Integrase core domain; Region: rve; pfam00665
1205675007788	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675007789	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1205675007790	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675007791	Walker A motif; other site
1205675007792	ATP binding site [chemical binding]; other site
1205675007793	Walker B motif; other site
1205675007794	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
1205675007795	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1205675007796	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
1205675007797	CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827
1205675007798	CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834
1205675007799	CRISPR-associated protein Csx17, subtype Dpsyc; Region: cas_csx17; TIGR04113
1205675007800	CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767
1205675007801	CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621
1205675007802	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1205675007803	Domain of unknown function (DUF1802); Region: DUF1802; cl01755
1205675007804	Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349
1205675007805	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1205675007806	putative active site [active]
1205675007807	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1205675007808	enoyl-CoA hydratase; Provisional; Region: PRK06190
1205675007809	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675007810	substrate binding site [chemical binding]; other site
1205675007811	oxyanion hole (OAH) forming residues; other site
1205675007812	trimer interface [polypeptide binding]; other site
1205675007813	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1205675007814	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1205675007815	Walker A/P-loop; other site
1205675007816	ATP binding site [chemical binding]; other site
1205675007817	Q-loop/lid; other site
1205675007818	ABC transporter signature motif; other site
1205675007819	Walker B; other site
1205675007820	D-loop; other site
1205675007821	H-loop/switch region; other site
1205675007822	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1205675007823	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1205675007824	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1205675007825	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675007826	dimer interface [polypeptide binding]; other site
1205675007827	conserved gate region; other site
1205675007828	putative PBP binding loops; other site
1205675007829	ABC-ATPase subunit interface; other site
1205675007830	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1205675007831	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675007832	dimer interface [polypeptide binding]; other site
1205675007833	conserved gate region; other site
1205675007834	putative PBP binding loops; other site
1205675007835	ABC-ATPase subunit interface; other site
1205675007836	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1205675007837	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1205675007838	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1205675007839	DHH family; Region: DHH; pfam01368
1205675007840	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1205675007841	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1205675007842	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1205675007843	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
1205675007844	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1205675007845	G1 box; other site
1205675007846	putative GEF interaction site [polypeptide binding]; other site
1205675007847	GTP/Mg2+ binding site [chemical binding]; other site
1205675007848	Switch I region; other site
1205675007849	G2 box; other site
1205675007850	G3 box; other site
1205675007851	Switch II region; other site
1205675007852	G4 box; other site
1205675007853	G5 box; other site
1205675007854	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1205675007855	Translation-initiation factor 2; Region: IF-2; pfam11987
1205675007856	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1205675007857	Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740
1205675007858	putative RNA binding cleft [nucleotide binding]; other site
1205675007859	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1205675007860	NusA N-terminal domain; Region: NusA_N; pfam08529
1205675007861	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1205675007862	RNA binding site [nucleotide binding]; other site
1205675007863	homodimer interface [polypeptide binding]; other site
1205675007864	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1205675007865	G-X-X-G motif; other site
1205675007866	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1205675007867	G-X-X-G motif; other site
1205675007868	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1205675007869	Sm and related proteins; Region: Sm_like; cl00259
1205675007870	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1205675007871	putative oligomer interface [polypeptide binding]; other site
1205675007872	putative RNA binding site [nucleotide binding]; other site
1205675007873	Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718
1205675007874	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1205675007875	dinuclear metal binding motif [ion binding]; other site
1205675007876	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1205675007877	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1205675007878	dimer interface [polypeptide binding]; other site
1205675007879	motif 1; other site
1205675007880	active site
1205675007881	motif 2; other site
1205675007882	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
1205675007883	putative deacylase active site [active]
1205675007884	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1205675007885	active site
1205675007886	motif 3; other site
1205675007887	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1205675007888	anticodon binding site; other site
1205675007889	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675007890	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1205675007891	putative substrate translocation pore; other site
1205675007892	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
1205675007893	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1205675007894	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1205675007895	homodimer interface [polypeptide binding]; other site
1205675007896	active site
1205675007897	SAM binding site [chemical binding]; other site
1205675007898	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1205675007899	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1205675007900	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1205675007901	catalytic triad [active]
1205675007902	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1205675007903	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1205675007904	homodimer interface [polypeptide binding]; other site
1205675007905	Walker A motif; other site
1205675007906	ATP binding site [chemical binding]; other site
1205675007907	hydroxycobalamin binding site [chemical binding]; other site
1205675007908	Walker B motif; other site
1205675007909	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
1205675007910	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675007911	Walker A motif; other site
1205675007912	ATP binding site [chemical binding]; other site
1205675007913	Walker B motif; other site
1205675007914	arginine finger; other site
1205675007915	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
1205675007916	metal ion-dependent adhesion site (MIDAS); other site
1205675007917	Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153
1205675007918	malate:quinone oxidoreductase; Validated; Region: PRK05257
1205675007919	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1205675007920	PE family; Region: PE; pfam00934
1205675007921	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1205675007922	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1205675007923	mycothione reductase; Reviewed; Region: PRK07846
1205675007924	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1205675007925	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1205675007926	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1205675007927	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
1205675007928	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1205675007929	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1205675007930	short chain dehydrogenase; Provisional; Region: PRK06057
1205675007931	classical (c) SDRs; Region: SDR_c; cd05233
1205675007932	NAD(P) binding site [chemical binding]; other site
1205675007933	active site
1205675007934	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1205675007935	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
1205675007936	NAD(P) binding site [chemical binding]; other site
1205675007937	catalytic residues [active]
1205675007938	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1205675007939	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1205675007940	catalytic triad [active]
1205675007941	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1205675007942	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1205675007943	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1205675007944	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1205675007945	active site
1205675007946	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1205675007947	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1205675007948	putative active site [active]
1205675007949	Integrase core domain; Region: rve; pfam00665
1205675007950	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675007951	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1205675007952	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675007953	Walker A motif; other site
1205675007954	ATP binding site [chemical binding]; other site
1205675007955	Walker B motif; other site
1205675007956	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1205675007957	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1205675007958	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1205675007959	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1205675007960	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1205675007961	Predicted acetyltransferase [General function prediction only]; Region: COG3393
1205675007962	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
1205675007963	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1205675007964	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1205675007965	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1205675007966	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1205675007967	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1205675007968	active site
1205675007969	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1205675007970	protein binding site [polypeptide binding]; other site
1205675007971	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1205675007972	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1205675007973	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1205675007974	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1205675007975	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1205675007976	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1205675007977	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
1205675007978	Fasciclin domain; Region: Fasciclin; pfam02469
1205675007979	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1205675007980	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1205675007981	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
1205675007982	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1205675007983	catalytic residues [active]
1205675007984	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
1205675007985	Fasciclin domain; Region: Fasciclin; pfam02469
1205675007986	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
1205675007987	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1205675007988	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
1205675007989	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1205675007990	catalytic residues [active]
1205675007991	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
1205675007992	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1205675007993	FeS/SAM binding site; other site
1205675007994	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1205675007995	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1205675007996	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1205675007997	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1205675007998	hinge region; other site
1205675007999	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1205675008000	putative nucleotide binding site [chemical binding]; other site
1205675008001	uridine monophosphate binding site [chemical binding]; other site
1205675008002	homohexameric interface [polypeptide binding]; other site
1205675008003	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1205675008004	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1205675008005	DNA binding site [nucleotide binding]
1205675008006	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1205675008007	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1205675008008	Probable transposase; Region: OrfB_IS605; pfam01385
1205675008009	Evidence 2b : Function of strongly homologous gene; PubMedId : 12657046, 15525680; Product type e : enzyme
1205675008010	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1205675008011	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675008012	Walker A motif; other site
1205675008013	ATP binding site [chemical binding]; other site
1205675008014	Walker B motif; other site
1205675008015	Integrase core domain; Region: rve; pfam00665
1205675008016	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675008017	Evidence 2b : Function of strongly homologous gene; PubMedId : 12657046, 15525680; Product type e : enzyme
1205675008018	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1205675008019	MarR family; Region: MarR; pfam01047
1205675008020	amidase; Provisional; Region: PRK07869
1205675008021	Amidase; Region: Amidase; pfam01425
1205675008022	elongation factor Ts; Provisional; Region: tsf; PRK09377
1205675008023	UBA/TS-N domain; Region: UBA; pfam00627
1205675008024	Elongation factor TS; Region: EF_TS; pfam00889
1205675008025	Elongation factor TS; Region: EF_TS; pfam00889
1205675008026	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1205675008027	rRNA interaction site [nucleotide binding]; other site
1205675008028	S8 interaction site; other site
1205675008029	putative laminin-1 binding site; other site
1205675008030	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1205675008031	Peptidase family M23; Region: Peptidase_M23; pfam01551
1205675008032	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675008033	PPE family; Region: PPE; pfam00823
1205675008034	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675008035	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
1205675008036	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1205675008037	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1205675008038	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1205675008039	active site
1205675008040	DNA binding site [nucleotide binding]
1205675008041	Int/Topo IB signature motif; other site
1205675008042	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1205675008043	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1205675008044	FAD binding pocket [chemical binding]; other site
1205675008045	FAD binding motif [chemical binding]; other site
1205675008046	phosphate binding motif [ion binding]; other site
1205675008047	NAD binding pocket [chemical binding]; other site
1205675008048	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1205675008049	DNA protecting protein DprA; Region: dprA; TIGR00732
1205675008050	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1205675008051	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1205675008052	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675008053	Walker A motif; other site
1205675008054	ATP binding site [chemical binding]; other site
1205675008055	Walker B motif; other site
1205675008056	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1205675008057	hypothetical protein; Reviewed; Region: PRK12497
1205675008058	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1205675008059	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1205675008060	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1205675008061	putative molybdopterin cofactor binding site [chemical binding]; other site
1205675008062	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1205675008063	putative molybdopterin cofactor binding site; other site
1205675008064	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
1205675008065	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1205675008066	RNA/DNA hybrid binding site [nucleotide binding]; other site
1205675008067	active site
1205675008068	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1205675008069	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1205675008070	Catalytic site [active]
1205675008071	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1205675008072	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1205675008073	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1205675008074	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1205675008075	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1205675008076	RimM N-terminal domain; Region: RimM; pfam01782
1205675008077	hypothetical protein; Provisional; Region: PRK02821
1205675008078	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1205675008079	G-X-X-G motif; other site
1205675008080	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
1205675008081	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
1205675008082	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1205675008083	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1205675008084	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675008085	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675008086	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
1205675008087	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
1205675008088	active site
1205675008089	putative substrate binding pocket [chemical binding]; other site
1205675008090	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1205675008091	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1205675008092	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1205675008093	active site
1205675008094	ATP binding site [chemical binding]; other site
1205675008095	substrate binding site [chemical binding]; other site
1205675008096	activation loop (A-loop); other site
1205675008097	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1205675008098	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
1205675008099	active site
1205675008100	signal recognition particle protein; Provisional; Region: PRK10867
1205675008101	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1205675008102	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1205675008103	P loop; other site
1205675008104	GTP binding site [chemical binding]; other site
1205675008105	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1205675008106	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1205675008107	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1205675008108	ATP binding site [chemical binding]; other site
1205675008109	putative Mg++ binding site [ion binding]; other site
1205675008110	PII uridylyl-transferase; Provisional; Region: PRK03381
1205675008111	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1205675008112	metal binding triad [ion binding]; metal-binding site
1205675008113	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1205675008114	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1205675008115	Zn2+ binding site [ion binding]; other site
1205675008116	Mg2+ binding site [ion binding]; other site
1205675008117	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1205675008118	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1205675008119	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1205675008120	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
1205675008121	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1205675008122	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1205675008123	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1205675008124	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1205675008125	Walker A/P-loop; other site
1205675008126	ATP binding site [chemical binding]; other site
1205675008127	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1205675008128	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1205675008129	ABC transporter signature motif; other site
1205675008130	Walker B; other site
1205675008131	D-loop; other site
1205675008132	H-loop/switch region; other site
1205675008133	acylphosphatase; Provisional; Region: PRK14422
1205675008134	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
1205675008135	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1205675008136	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1205675008137	DNA binding site [nucleotide binding]
1205675008138	catalytic residue [active]
1205675008139	H2TH interface [polypeptide binding]; other site
1205675008140	putative catalytic residues [active]
1205675008141	turnover-facilitating residue; other site
1205675008142	intercalation triad [nucleotide binding]; other site
1205675008143	8OG recognition residue [nucleotide binding]; other site
1205675008144	putative reading head residues; other site
1205675008145	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1205675008146	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1205675008147	ribonuclease III; Reviewed; Region: rnc; PRK00102
1205675008148	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1205675008149	dimerization interface [polypeptide binding]; other site
1205675008150	active site
1205675008151	metal binding site [ion binding]; metal-binding site
1205675008152	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1205675008153	dsRNA binding site [nucleotide binding]; other site
1205675008154	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1205675008155	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1205675008156	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1205675008157	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1205675008158	acyl-CoA synthetase; Validated; Region: PRK05850
1205675008159	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1205675008160	acyl-activating enzyme (AAE) consensus motif; other site
1205675008161	active site
1205675008162	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1205675008163	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1205675008164	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675008165	active site
1205675008166	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
1205675008167	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1205675008168	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
1205675008169	NADP binding site [chemical binding]; other site
1205675008170	KR domain; Region: KR; pfam08659
1205675008171	active site
1205675008172	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675008173	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675008174	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1205675008175	active site
1205675008176	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1205675008177	Acyl transferase domain; Region: Acyl_transf_1; cl08282
1205675008178	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
1205675008179	KR domain; Region: KR; pfam08659
1205675008180	NADP binding site [chemical binding]; other site
1205675008181	active site
1205675008182	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675008183	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1205675008184	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675008185	active site
1205675008186	Acyl transferase domain; Region: Acyl_transf_1; cl08282
1205675008187	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1205675008188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675008189	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1205675008190	Enoylreductase; Region: PKS_ER; smart00829
1205675008191	NAD(P) binding site [chemical binding]; other site
1205675008192	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1205675008193	KR domain; Region: KR; pfam08659
1205675008194	putative NADP binding site [chemical binding]; other site
1205675008195	active site
1205675008196	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675008197	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1205675008198	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675008199	active site
1205675008200	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1205675008201	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1205675008202	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1205675008203	KR domain; Region: KR; pfam08659
1205675008204	putative NADP binding site [chemical binding]; other site
1205675008205	active site
1205675008206	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675008207	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1205675008208	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675008209	active site
1205675008210	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1205675008211	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1205675008212	Condensation domain; Region: Condensation; pfam00668
1205675008213	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1205675008214	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1205675008215	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1205675008216	Walker A/P-loop; other site
1205675008217	ATP binding site [chemical binding]; other site
1205675008218	Q-loop/lid; other site
1205675008219	ABC transporter signature motif; other site
1205675008220	Walker B; other site
1205675008221	D-loop; other site
1205675008222	H-loop/switch region; other site
1205675008223	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1205675008224	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
1205675008225	ABC transporter efflux protein, DrrB family; Region: Mtu_efflux; TIGR00025
1205675008226	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1205675008227	acyltransferase PapA5; Provisional; Region: PRK09294
1205675008228	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1205675008229	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675008230	active site
1205675008231	Acyl transferase domain; Region: Acyl_transf_1; pfam00698
1205675008232	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1205675008233	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675008234	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1205675008235	Enoylreductase; Region: PKS_ER; smart00829
1205675008236	NAD(P) binding site [chemical binding]; other site
1205675008237	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1205675008238	KR domain; Region: KR; pfam08659
1205675008239	putative NADP binding site [chemical binding]; other site
1205675008240	active site
1205675008241	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675008242	acyl-CoA synthetase; Validated; Region: PRK05850
1205675008243	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1205675008244	acyl-activating enzyme (AAE) consensus motif; other site
1205675008245	active site
1205675008246	MMPL family; Region: MMPL; pfam03176
1205675008247	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
1205675008248	Erythronolide synthase docking; Region: Docking; pfam08990
1205675008249	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1205675008250	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675008251	active site
1205675008252	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1205675008253	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1205675008254	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675008255	Enoylreductase; Region: PKS_ER; smart00829
1205675008256	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1205675008257	NAD(P) binding site [chemical binding]; other site
1205675008258	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956
1205675008259	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1205675008260	putative NADP binding site [chemical binding]; other site
1205675008261	active site
1205675008262	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675008263	acyl-CoA synthetase; Validated; Region: PRK06060
1205675008264	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675008265	acyl-activating enzyme (AAE) consensus motif; other site
1205675008266	AMP binding site [chemical binding]; other site
1205675008267	active site
1205675008268	CoA binding site [chemical binding]; other site
1205675008269	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675008270	4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161
1205675008271	acyl-CoA synthetase; Validated; Region: PRK05850
1205675008272	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1205675008273	acyl-activating enzyme (AAE) consensus motif; other site
1205675008274	active site
1205675008275	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1205675008276	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1205675008277	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675008278	S-adenosylmethionine binding site [chemical binding]; other site
1205675008279	Uncharacterized conserved protein [Function unknown]; Region: COG3268
1205675008280	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1205675008281	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675008282	S-adenosylmethionine binding site [chemical binding]; other site
1205675008283	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1205675008284	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1205675008285	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
1205675008286	metal-binding site
1205675008287	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1205675008288	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1205675008289	active site
1205675008290	TDP-binding site; other site
1205675008291	acceptor substrate-binding pocket; other site
1205675008292	Cephalosporin hydroxylase [Defense mechanisms]; Region: CmcI; COG3510
1205675008293	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
1205675008294	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1205675008295	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1205675008296	active site
1205675008297	TDP-binding site; other site
1205675008298	acceptor substrate-binding pocket; other site
1205675008299	Predicted permease; Region: DUF318; pfam03773
1205675008300	formyltetrahydrofolate deformylase; Region: PurU; TIGR00655
1205675008301	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1205675008302	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1205675008303	putative active site [active]
1205675008304	putative substrate binding site [chemical binding]; other site
1205675008305	putative cosubstrate binding site; other site
1205675008306	catalytic site [active]
1205675008307	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1205675008308	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1205675008309	active site
1205675008310	(T/H)XGH motif; other site
1205675008311	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1205675008312	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675008313	S-adenosylmethionine binding site [chemical binding]; other site
1205675008314	pyruvate carboxylase; Reviewed; Region: PRK12999
1205675008315	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1205675008316	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1205675008317	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1205675008318	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1205675008319	active site
1205675008320	catalytic residues [active]
1205675008321	metal binding site [ion binding]; metal-binding site
1205675008322	homodimer binding site [polypeptide binding]; other site
1205675008323	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1205675008324	carboxyltransferase (CT) interaction site; other site
1205675008325	biotinylation site [posttranslational modification]; other site
1205675008326	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
1205675008327	putative active site [active]
1205675008328	redox center [active]
1205675008329	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1205675008330	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
1205675008331	catalytic residues [active]
1205675008332	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1205675008333	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1205675008334	substrate binding pocket [chemical binding]; other site
1205675008335	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
1205675008336	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1205675008337	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1205675008338	active site
1205675008339	catalytic tetrad [active]
1205675008340	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1205675008341	RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
1205675008342	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1205675008343	generic binding surface II; other site
1205675008344	ssDNA binding site; other site
1205675008345	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1205675008346	ATP binding site [chemical binding]; other site
1205675008347	putative Mg++ binding site [ion binding]; other site
1205675008348	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1205675008349	nucleotide binding region [chemical binding]; other site
1205675008350	ATP-binding site [chemical binding]; other site
1205675008351	DAK2 domain; Region: Dak2; cl03685
1205675008352	Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684
1205675008353	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1205675008354	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1205675008355	ligand binding site [chemical binding]; other site
1205675008356	active site
1205675008357	UGI interface [polypeptide binding]; other site
1205675008358	catalytic site [active]
1205675008359	thiamine monophosphate kinase; Provisional; Region: PRK05731
1205675008360	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1205675008361	ATP binding site [chemical binding]; other site
1205675008362	dimerization interface [polypeptide binding]; other site
1205675008363	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
1205675008364	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1205675008365	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1205675008366	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1205675008367	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1205675008368	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1205675008369	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1205675008370	Predicted nucleotidyltransferase, CobY/MobA/RfbA family [General function prediction only]; Region: COG1920
1205675008371	polyphosphate kinase; Provisional; Region: PRK05443
1205675008372	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1205675008373	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1205675008374	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1205675008375	putative domain interface [polypeptide binding]; other site
1205675008376	putative active site [active]
1205675008377	catalytic site [active]
1205675008378	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1205675008379	putative domain interface [polypeptide binding]; other site
1205675008380	putative active site [active]
1205675008381	catalytic site [active]
1205675008382	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1205675008383	active site
1205675008384	Ap6A binding site [chemical binding]; other site
1205675008385	nudix motif; other site
1205675008386	metal binding site [ion binding]; metal-binding site
1205675008387	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1205675008388	catalytic core [active]
1205675008389	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1205675008390	IHF - DNA interface [nucleotide binding]; other site
1205675008391	IHF dimer interface [polypeptide binding]; other site
1205675008392	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1205675008393	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1205675008394	substrate binding site [chemical binding]; other site
1205675008395	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1205675008396	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1205675008397	substrate binding site [chemical binding]; other site
1205675008398	ligand binding site [chemical binding]; other site
1205675008399	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1205675008400	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1205675008401	Bacterial transcriptional regulator; Region: IclR; pfam01614
1205675008402	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675008403	S-adenosylmethionine binding site [chemical binding]; other site
1205675008404	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
1205675008405	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1205675008406	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1205675008407	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1205675008408	active site
1205675008409	HIGH motif; other site
1205675008410	nucleotide binding site [chemical binding]; other site
1205675008411	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1205675008412	active site
1205675008413	KMSKS motif; other site
1205675008414	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1205675008415	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
1205675008416	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1205675008417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675008418	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1205675008419	putative substrate translocation pore; other site
1205675008420	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
1205675008421	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1205675008422	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1205675008423	ligand binding site [chemical binding]; other site
1205675008424	NAD binding site [chemical binding]; other site
1205675008425	dimerization interface [polypeptide binding]; other site
1205675008426	catalytic site [active]
1205675008427	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1205675008428	putative L-serine binding site [chemical binding]; other site
1205675008429	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1205675008430	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1205675008431	sensor protein BasS/PmrB; Provisional; Region: PRK10755
1205675008432	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
1205675008433	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
1205675008434	Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485
1205675008435	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1205675008436	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1205675008437	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1205675008438	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1205675008439	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1205675008440	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1205675008441	putative valine binding site [chemical binding]; other site
1205675008442	dimer interface [polypeptide binding]; other site
1205675008443	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1205675008444	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
1205675008445	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1205675008446	PYR/PP interface [polypeptide binding]; other site
1205675008447	dimer interface [polypeptide binding]; other site
1205675008448	TPP binding site [chemical binding]; other site
1205675008449	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1205675008450	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1205675008451	TPP-binding site [chemical binding]; other site
1205675008452	dimer interface [polypeptide binding]; other site
1205675008453	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1205675008454	Predicted membrane protein [Function unknown]; Region: COG2259
1205675008455	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
1205675008456	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1205675008457	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1205675008458	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1205675008459	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1205675008460	GatB domain; Region: GatB_Yqey; smart00845
1205675008461	6-phosphofructokinase; Provisional; Region: PRK03202
1205675008462	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1205675008463	active site
1205675008464	ADP/pyrophosphate binding site [chemical binding]; other site
1205675008465	dimerization interface [polypeptide binding]; other site
1205675008466	allosteric effector site; other site
1205675008467	fructose-1,6-bisphosphate binding site; other site
1205675008468	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1205675008469	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1205675008470	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1205675008471	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
1205675008472	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1205675008473	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1205675008474	nucleotide binding pocket [chemical binding]; other site
1205675008475	K-X-D-G motif; other site
1205675008476	catalytic site [active]
1205675008477	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1205675008478	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1205675008479	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1205675008480	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1205675008481	Dimer interface [polypeptide binding]; other site
1205675008482	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
1205675008483	PknH-like extracellular domain; Region: PknH_C; pfam14032
1205675008484	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1205675008485	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1205675008486	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675008487	PPE family; Region: PPE; pfam00823
1205675008488	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1205675008489	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1205675008490	Ligand Binding Site [chemical binding]; other site
1205675008491	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1205675008492	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1205675008493	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1205675008494	catalytic residue [active]
1205675008495	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1205675008496	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1205675008497	putative acyl-acceptor binding pocket; other site
1205675008498	Putative hemolysin [General function prediction only]; Region: COG3176
1205675008499	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1205675008500	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1205675008501	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1205675008502	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1205675008503	Ligand binding site [chemical binding]; other site
1205675008504	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1205675008505	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675008506	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1205675008507	S-adenosylmethionine binding site [chemical binding]; other site
1205675008508	Uncharacterized conserved protein [Function unknown]; Region: COG1543
1205675008509	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
1205675008510	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
1205675008511	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1205675008512	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1205675008513	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
1205675008514	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
1205675008515	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1205675008516	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1205675008517	trimer interface [polypeptide binding]; other site
1205675008518	active site
1205675008519	substrate binding site [chemical binding]; other site
1205675008520	CoA binding site [chemical binding]; other site
1205675008521	FOG: WD40-like repeat [Function unknown]; Region: COG1520
1205675008522	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1205675008523	active site
1205675008524	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1205675008525	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675008526	S-adenosylmethionine binding site [chemical binding]; other site
1205675008527	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675008528	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1205675008529	substrate binding site [chemical binding]; other site
1205675008530	oxyanion hole (OAH) forming residues; other site
1205675008531	trimer interface [polypeptide binding]; other site
1205675008532	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
1205675008533	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1205675008534	Walker A/P-loop; other site
1205675008535	ATP binding site [chemical binding]; other site
1205675008536	Q-loop/lid; other site
1205675008537	ABC transporter signature motif; other site
1205675008538	Walker B; other site
1205675008539	D-loop; other site
1205675008540	H-loop/switch region; other site
1205675008541	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
1205675008542	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
1205675008543	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1205675008544	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1205675008545	motif II; other site
1205675008546	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1205675008547	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1205675008548	D-pathway; other site
1205675008549	Putative ubiquinol binding site [chemical binding]; other site
1205675008550	Low-spin heme (heme b) binding site [chemical binding]; other site
1205675008551	Putative water exit pathway; other site
1205675008552	Binuclear center (heme o3/CuB) [ion binding]; other site
1205675008553	K-pathway; other site
1205675008554	Putative proton exit pathway; other site
1205675008555	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1205675008556	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1205675008557	siderophore binding site; other site
1205675008558	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1205675008559	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1205675008560	putative NAD(P) binding site [chemical binding]; other site
1205675008561	putative substrate binding site [chemical binding]; other site
1205675008562	catalytic Zn binding site [ion binding]; other site
1205675008563	structural Zn binding site [ion binding]; other site
1205675008564	dimer interface [polypeptide binding]; other site
1205675008565	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
1205675008566	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1205675008567	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1205675008568	dimer interface [polypeptide binding]; other site
1205675008569	putative radical transfer pathway; other site
1205675008570	diiron center [ion binding]; other site
1205675008571	tyrosyl radical; other site
1205675008572	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1205675008573	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1205675008574	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675008575	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675008576	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
1205675008577	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1205675008578	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1205675008579	active site
1205675008580	dimer interface [polypeptide binding]; other site
1205675008581	catalytic residues [active]
1205675008582	effector binding site; other site
1205675008583	R2 peptide binding site; other site
1205675008584	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1205675008585	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1205675008586	catalytic residues [active]
1205675008587	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1205675008588	Predicted flavoprotein [General function prediction only]; Region: COG0431
1205675008589	DNA polymerase IV; Validated; Region: PRK03352
1205675008590	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1205675008591	active site
1205675008592	DNA binding site [nucleotide binding]
1205675008593	short chain dehydrogenase; Provisional; Region: PRK07832
1205675008594	classical (c) SDRs; Region: SDR_c; cd05233
1205675008595	NAD(P) binding site [chemical binding]; other site
1205675008596	active site
1205675008597	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675008598	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675008599	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675008600	Cytochrome P450; Region: p450; cl12078
1205675008601	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1205675008602	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1205675008603	DNA-binding site [nucleotide binding]; DNA binding site
1205675008604	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1205675008605	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1205675008606	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1205675008607	DNA-binding site [nucleotide binding]; DNA binding site
1205675008608	FCD domain; Region: FCD; pfam07729
1205675008609	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675008610	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1205675008611	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675008612	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675008613	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675008614	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675008615	active site
1205675008616	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
1205675008617	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
1205675008618	active site
1205675008619	DNA binding site [nucleotide binding]
1205675008620	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
1205675008621	DNA binding site [nucleotide binding]
1205675008622	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
1205675008623	Carbon starvation protein CstA; Region: CstA; pfam02554
1205675008624	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1205675008625	Predicted membrane protein [Function unknown]; Region: COG2259
1205675008626	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
1205675008627	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1205675008628	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675008629	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1205675008630	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
1205675008631	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1205675008632	active site
1205675008633	substrate binding site [chemical binding]; other site
1205675008634	metal binding site [ion binding]; metal-binding site
1205675008635	camphor resistance protein CrcB; Provisional; Region: PRK14216
1205675008636	camphor resistance protein CrcB; Provisional; Region: PRK14228
1205675008637	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
1205675008638	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
1205675008639	Uncharacterized ACR, COG1993; Region: DUF190; pfam02641
1205675008640	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1205675008641	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1205675008642	Protein of unknown function, DUF488; Region: DUF488; cl01246
1205675008643	Protein of unknown function, DUF488; Region: DUF488; cl01246
1205675008644	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675008645	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675008646	active site
1205675008647	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1205675008648	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1205675008649	putative hydrophobic ligand binding site [chemical binding]; other site
1205675008650	protein interface [polypeptide binding]; other site
1205675008651	gate; other site
1205675008652	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1205675008653	Sulfatase; Region: Sulfatase; pfam00884
1205675008654	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1205675008655	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1205675008656	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1205675008657	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1205675008658	active site
1205675008659	ATP binding site [chemical binding]; other site
1205675008660	substrate binding site [chemical binding]; other site
1205675008661	activation loop (A-loop); other site
1205675008662	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
1205675008663	AAA ATPase domain; Region: AAA_16; pfam13191
1205675008664	Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690
1205675008665	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1205675008666	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1205675008667	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1205675008668	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1205675008669	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1205675008670	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1205675008671	short chain dehydrogenase; Provisional; Region: PRK07832
1205675008672	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675008673	NAD(P) binding site [chemical binding]; other site
1205675008674	active site
1205675008675	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
1205675008676	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1205675008677	NAD binding site [chemical binding]; other site
1205675008678	catalytic Zn binding site [ion binding]; other site
1205675008679	substrate binding site [chemical binding]; other site
1205675008680	structural Zn binding site [ion binding]; other site
1205675008681	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1205675008682	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1205675008683	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1205675008684	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1205675008685	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
1205675008686	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1205675008687	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675008688	acyl-activating enzyme (AAE) consensus motif; other site
1205675008689	AMP binding site [chemical binding]; other site
1205675008690	active site
1205675008691	CoA binding site [chemical binding]; other site
1205675008692	SPFH domain / Band 7 family; Region: Band_7; pfam01145
1205675008693	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1205675008694	Patatin-like phospholipase; Region: Patatin; pfam01734
1205675008695	Protein of unknown function (DUF808); Region: DUF808; cl01002
1205675008696	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
1205675008697	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1205675008698	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675008699	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675008700	active site
1205675008701	Predicted transcriptional regulators [Transcription]; Region: COG1733
1205675008702	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1205675008703	dimerization interface [polypeptide binding]; other site
1205675008704	putative DNA binding site [nucleotide binding]; other site
1205675008705	putative Zn2+ binding site [ion binding]; other site
1205675008706	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
1205675008707	PE family; Region: PE; pfam00934
1205675008708	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1205675008709	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1205675008710	PemK-like protein; Region: PemK; pfam02452
1205675008711	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1205675008712	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1205675008713	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1205675008714	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1205675008715	SmpB-tmRNA interface; other site
1205675008716	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1205675008717	FtsX-like permease family; Region: FtsX; pfam02687
1205675008718	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1205675008719	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1205675008720	Walker A/P-loop; other site
1205675008721	ATP binding site [chemical binding]; other site
1205675008722	Q-loop/lid; other site
1205675008723	ABC transporter signature motif; other site
1205675008724	Walker B; other site
1205675008725	D-loop; other site
1205675008726	H-loop/switch region; other site
1205675008727	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1205675008728	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1205675008729	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1205675008730	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1205675008731	RF-1 domain; Region: RF-1; pfam00472
1205675008732	ferredoxin-NADP+ reductase; Region: PLN02852
1205675008733	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1205675008734	FAD binding domain; Region: FAD_binding_4; pfam01565
1205675008735	Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896
1205675008736	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1205675008737	FeS/SAM binding site; other site
1205675008738	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1205675008739	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
1205675008740	aromatic arch; other site
1205675008741	DCoH dimer interaction site [polypeptide binding]; other site
1205675008742	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1205675008743	DCoH tetramer interaction site [polypeptide binding]; other site
1205675008744	substrate binding site [chemical binding]; other site
1205675008745	Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10510226, 11416222, 11929527, 12694625, 12933881, 15525680
1205675008746	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1205675008747	MULE transposase domain; Region: MULE; pfam10551
1205675008748	Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10510226, 11416222, 11929527, 12694625, 12933881, 15525680
1205675008749	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1205675008750	Transposase; Region: HTH_Tnp_1; cl17663
1205675008751	putative transposase OrfB; Reviewed; Region: PHA02517
1205675008752	HTH-like domain; Region: HTH_21; pfam13276
1205675008753	Integrase core domain; Region: rve; pfam00665
1205675008754	Integrase core domain; Region: rve_3; pfam13683
1205675008755	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1205675008756	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1205675008757	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1205675008758	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1205675008759	dimer interface [polypeptide binding]; other site
1205675008760	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1205675008761	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1205675008762	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1205675008763	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1205675008764	Histidine kinase; Region: HisKA_3; pfam07730
1205675008765	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1205675008766	ATP binding site [chemical binding]; other site
1205675008767	Mg2+ binding site [ion binding]; other site
1205675008768	G-X-G motif; other site
1205675008769	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1205675008770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1205675008771	active site
1205675008772	phosphorylation site [posttranslational modification]
1205675008773	intermolecular recognition site; other site
1205675008774	dimerization interface [polypeptide binding]; other site
1205675008775	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1205675008776	DNA binding residues [nucleotide binding]
1205675008777	dimerization interface [polypeptide binding]; other site
1205675008778	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1205675008779	Ligand Binding Site [chemical binding]; other site
1205675008780	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675008781	PPE family; Region: PPE; pfam00823
1205675008782	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675008783	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675008784	PPE family; Region: PPE; pfam00823
1205675008785	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675008786	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1205675008787	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
1205675008788	active site
1205675008789	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
1205675008790	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1205675008791	FeS/SAM binding site; other site
1205675008792	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675008793	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675008794	active site
1205675008795	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675008796	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675008797	active site
1205675008798	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1205675008799	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1205675008800	NAD(P) binding site [chemical binding]; other site
1205675008801	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1205675008802	active site
1205675008803	phosphorylation site [posttranslational modification]
1205675008804	intermolecular recognition site; other site
1205675008805	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675008806	PPE family; Region: PPE; pfam00823
1205675008807	NADH dehydrogenase subunit A; Validated; Region: PRK07928
1205675008808	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1205675008809	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
1205675008810	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1205675008811	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
1205675008812	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1205675008813	NADH dehydrogenase subunit E; Validated; Region: PRK07539
1205675008814	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1205675008815	putative dimer interface [polypeptide binding]; other site
1205675008816	[2Fe-2S] cluster binding site [ion binding]; other site
1205675008817	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
1205675008818	SLBB domain; Region: SLBB; pfam10531
1205675008819	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
1205675008820	NADH dehydrogenase subunit G; Validated; Region: PRK07860
1205675008821	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1205675008822	catalytic loop [active]
1205675008823	iron binding site [ion binding]; other site
1205675008824	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1205675008825	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1205675008826	molybdopterin cofactor binding site; other site
1205675008827	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
1205675008828	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1205675008829	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1205675008830	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1205675008831	4Fe-4S binding domain; Region: Fer4; pfam00037
1205675008832	4Fe-4S binding domain; Region: Fer4; pfam00037
1205675008833	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1205675008834	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1205675008835	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1205675008836	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1205675008837	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1205675008838	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1205675008839	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1205675008840	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1205675008841	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1205675008842	PPE family; Region: PPE; pfam00823
1205675008843	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675008844	PPE family; Region: PPE; pfam00823
1205675008845	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
1205675008846	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675008847	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1205675008848	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1205675008849	[2Fe-2S] cluster binding site [ion binding]; other site
1205675008850	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885
1205675008851	putative alpha subunit interface [polypeptide binding]; other site
1205675008852	putative active site [active]
1205675008853	putative substrate binding site [chemical binding]; other site
1205675008854	Fe binding site [ion binding]; other site
1205675008855	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1205675008856	Protein of unknown function DUF58; Region: DUF58; pfam01882
1205675008857	MoxR-like ATPases [General function prediction only]; Region: COG0714
1205675008858	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675008859	Walker A motif; other site
1205675008860	ATP binding site [chemical binding]; other site
1205675008861	Walker B motif; other site
1205675008862	arginine finger; other site
1205675008863	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1205675008864	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675008865	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675008866	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
1205675008867	putative active site [active]
1205675008868	putative substrate binding site [chemical binding]; other site
1205675008869	ATP binding site [chemical binding]; other site
1205675008870	Phosphotransferase enzyme family; Region: APH; pfam01636
1205675008871	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1205675008872	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1205675008873	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1205675008874	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675008875	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1205675008876	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675008877	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675008878	short chain dehydrogenase; Validated; Region: PRK08264
1205675008879	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675008880	NAD(P) binding site [chemical binding]; other site
1205675008881	active site
1205675008882	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
1205675008883	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
1205675008884	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675008885	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675008886	TAP-like protein; Region: Abhydrolase_4; pfam08386
1205675008887	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1205675008888	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
1205675008889	AAA domain; Region: AAA_14; pfam13173
1205675008890	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1205675008891	Transposase; Region: HTH_Tnp_1; cl17663
1205675008892	putative transposase OrfB; Reviewed; Region: PHA02517
1205675008893	HTH-like domain; Region: HTH_21; pfam13276
1205675008894	Integrase core domain; Region: rve; pfam00665
1205675008895	Integrase core domain; Region: rve_3; pfam13683
1205675008896	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1205675008897	MULE transposase domain; Region: MULE; pfam10551
1205675008898	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1205675008899	putative active site [active]
1205675008900	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1205675008901	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683
1205675008902	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1205675008903	non-specific DNA binding site [nucleotide binding]; other site
1205675008904	salt bridge; other site
1205675008905	sequence-specific DNA binding site [nucleotide binding]; other site
1205675008906	putative transposase OrfB; Reviewed; Region: PHA02517
1205675008907	HTH-like domain; Region: HTH_21; pfam13276
1205675008908	Integrase core domain; Region: rve; pfam00665
1205675008909	Integrase core domain; Region: rve_3; pfam13683
1205675008910	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1205675008911	Transposase; Region: HTH_Tnp_1; cl17663
1205675008912	RES domain; Region: RES; cl02411
1205675008913	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1205675008914	Transposase; Region: HTH_Tnp_1; cl17663
1205675008915	putative transposase OrfB; Reviewed; Region: PHA02517
1205675008916	HTH-like domain; Region: HTH_21; pfam13276
1205675008917	Integrase core domain; Region: rve; pfam00665
1205675008918	Integrase core domain; Region: rve_3; pfam13683
1205675008919	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1205675008920	Helix-turn-helix domain; Region: HTH_38; pfam13936
1205675008921	Integrase core domain; Region: rve; pfam00665
1205675008922	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
1205675008923	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1205675008924	hypothetical protein; Validated; Region: PRK00068
1205675008925	Uncharacterized conserved protein [Function unknown]; Region: COG1615
1205675008926	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
1205675008927	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1205675008928	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
1205675008929	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1205675008930	Uncharacterized conserved protein [Function unknown]; Region: COG5282
1205675008931	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
1205675008932	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
1205675008933	ABC1 family; Region: ABC1; pfam03109
1205675008934	Phosphotransferase enzyme family; Region: APH; pfam01636
1205675008935	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1205675008936	active site
1205675008937	ATP binding site [chemical binding]; other site
1205675008938	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1205675008939	Part of AAA domain; Region: AAA_19; pfam13245
1205675008940	Family description; Region: UvrD_C_2; pfam13538
1205675008941	HRDC domain; Region: HRDC; pfam00570
1205675008942	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1205675008943	catalytic residues [active]
1205675008944	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
1205675008945	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
1205675008946	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1205675008947	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1205675008948	putative NADH binding site [chemical binding]; other site
1205675008949	putative active site [active]
1205675008950	nudix motif; other site
1205675008951	putative metal binding site [ion binding]; other site
1205675008952	Ion channel; Region: Ion_trans_2; pfam07885
1205675008953	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1205675008954	TrkA-N domain; Region: TrkA_N; pfam02254
1205675008955	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1205675008956	Part of AAA domain; Region: AAA_19; pfam13245
1205675008957	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
1205675008958	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1205675008959	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1205675008960	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
1205675008961	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1205675008962	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1205675008963	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1205675008964	active site
1205675008965	DNA binding site [nucleotide binding]
1205675008966	TIGR02569 family protein; Region: TIGR02569_actnb
1205675008967	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
1205675008968	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1205675008969	ATP binding site [chemical binding]; other site
1205675008970	substrate interface [chemical binding]; other site
1205675008971	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1205675008972	active site residue [active]
1205675008973	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
1205675008974	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675008975	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675008976	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
1205675008977	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794
1205675008978	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1205675008979	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1205675008980	ATP binding site [chemical binding]; other site
1205675008981	Mg++ binding site [ion binding]; other site
1205675008982	motif III; other site
1205675008983	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1205675008984	nucleotide binding region [chemical binding]; other site
1205675008985	ATP-binding site [chemical binding]; other site
1205675008986	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1205675008987	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1205675008988	P-loop; other site
1205675008989	Magnesium ion binding site [ion binding]; other site
1205675008990	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1205675008991	Magnesium ion binding site [ion binding]; other site
1205675008992	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1205675008993	catalytic core [active]
1205675008994	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1205675008995	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1205675008996	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1205675008997	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1205675008998	Transcription factor WhiB; Region: Whib; pfam02467
1205675008999	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
1205675009000	PAS domain S-box; Region: sensory_box; TIGR00229
1205675009001	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1205675009002	Histidine kinase; Region: HisKA_2; pfam07568
1205675009003	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1205675009004	ATP binding site [chemical binding]; other site
1205675009005	Mg2+ binding site [ion binding]; other site
1205675009006	G-X-G motif; other site
1205675009007	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1205675009008	carboxyltransferase (CT) interaction site; other site
1205675009009	biotinylation site [posttranslational modification]; other site
1205675009010	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
1205675009011	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
1205675009012	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1205675009013	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1205675009014	DNA binding residues [nucleotide binding]
1205675009015	short chain dehydrogenase; Provisional; Region: PRK08278
1205675009016	human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762
1205675009017	NAD(P) binding site [chemical binding]; other site
1205675009018	homodimer interface [polypeptide binding]; other site
1205675009019	active site
1205675009020	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
1205675009021	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
1205675009022	putative deacylase active site [active]
1205675009023	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1205675009024	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1205675009025	Coenzyme A binding pocket [chemical binding]; other site
1205675009026	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
1205675009027	Phosphotransferase enzyme family; Region: APH; pfam01636
1205675009028	putative active site [active]
1205675009029	putative substrate binding site [chemical binding]; other site
1205675009030	ATP binding site [chemical binding]; other site
1205675009031	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1205675009032	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1205675009033	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1205675009034	hinge; other site
1205675009035	active site
1205675009036	Predicted GTPases [General function prediction only]; Region: COG1162
1205675009037	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1205675009038	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1205675009039	GTP/Mg2+ binding site [chemical binding]; other site
1205675009040	G4 box; other site
1205675009041	G5 box; other site
1205675009042	G1 box; other site
1205675009043	Switch I region; other site
1205675009044	G2 box; other site
1205675009045	G3 box; other site
1205675009046	Switch II region; other site
1205675009047	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1205675009048	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1205675009049	putative di-iron ligands [ion binding]; other site
1205675009050	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
1205675009051	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1205675009052	FAD binding pocket [chemical binding]; other site
1205675009053	FAD binding motif [chemical binding]; other site
1205675009054	phosphate binding motif [ion binding]; other site
1205675009055	beta-alpha-beta structure motif; other site
1205675009056	NAD binding pocket [chemical binding]; other site
1205675009057	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1205675009058	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1205675009059	catalytic loop [active]
1205675009060	iron binding site [ion binding]; other site
1205675009061	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1205675009062	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1205675009063	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1205675009064	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1205675009065	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1205675009066	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
1205675009067	TrkA-C domain; Region: TrkA_C; pfam02080
1205675009068	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1205675009069	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675009070	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1205675009071	putative substrate translocation pore; other site
1205675009072	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1205675009073	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1205675009074	ligand binding site [chemical binding]; other site
1205675009075	flexible hinge region; other site
1205675009076	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1205675009077	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1205675009078	nucleophile elbow; other site
1205675009079	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1205675009080	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1205675009081	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1205675009082	30S subunit binding site; other site
1205675009083	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1205675009084	active site
1205675009085	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
1205675009086	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1205675009087	lipoprotein LpqB; Provisional; Region: PRK13616
1205675009088	Sporulation and spore germination; Region: Germane; pfam10646
1205675009089	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1205675009090	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1205675009091	dimerization interface [polypeptide binding]; other site
1205675009092	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1205675009093	dimer interface [polypeptide binding]; other site
1205675009094	phosphorylation site [posttranslational modification]
1205675009095	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1205675009096	ATP binding site [chemical binding]; other site
1205675009097	Mg2+ binding site [ion binding]; other site
1205675009098	G-X-G motif; other site
1205675009099	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1205675009100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1205675009101	active site
1205675009102	phosphorylation site [posttranslational modification]
1205675009103	intermolecular recognition site; other site
1205675009104	dimerization interface [polypeptide binding]; other site
1205675009105	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1205675009106	DNA binding site [nucleotide binding]
1205675009107	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
1205675009108	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1205675009109	TMP-binding site; other site
1205675009110	ATP-binding site [chemical binding]; other site
1205675009111	Adenosylhomocysteinase; Provisional; Region: PTZ00075
1205675009112	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1205675009113	homotetramer interface [polypeptide binding]; other site
1205675009114	ligand binding site [chemical binding]; other site
1205675009115	catalytic site [active]
1205675009116	NAD binding site [chemical binding]; other site
1205675009117	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675009118	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1205675009119	Rubredoxin [Energy production and conversion]; Region: COG1773
1205675009120	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1205675009121	iron binding site [ion binding]; other site
1205675009122	Rubredoxin [Energy production and conversion]; Region: COG1773
1205675009123	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1205675009124	iron binding site [ion binding]; other site
1205675009125	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
1205675009126	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1205675009127	Di-iron ligands [ion binding]; other site
1205675009128	amino acid transporter; Region: 2A0306; TIGR00909
1205675009129	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1205675009130	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1205675009131	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1205675009132	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1205675009133	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1205675009134	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1205675009135	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
1205675009136	active site
1205675009137	substrate binding site [chemical binding]; other site
1205675009138	metal binding site [ion binding]; metal-binding site
1205675009139	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
1205675009140	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
1205675009141	Transcription factor WhiB; Region: Whib; pfam02467
1205675009142	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
1205675009143	LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186
1205675009144	phosphate binding site [ion binding]; other site
1205675009145	dimer interface [polypeptide binding]; other site
1205675009146	substrate binding site [chemical binding]; other site
1205675009147	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
1205675009148	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
1205675009149	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
1205675009150	putative FMN binding site [chemical binding]; other site
1205675009151	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1205675009152	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1205675009153	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1205675009154	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1205675009155	active site
1205675009156	Substrate binding site; other site
1205675009157	Mg++ binding site; other site
1205675009158	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1205675009159	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1205675009160	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1205675009161	Probable Catalytic site; other site
1205675009162	metal-binding site
1205675009163	dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214
1205675009164	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1205675009165	NADP binding site [chemical binding]; other site
1205675009166	active site
1205675009167	putative substrate binding site [chemical binding]; other site
1205675009168	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1205675009169	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1205675009170	TIGR03089 family protein; Region: TIGR03089
1205675009171	Protein of unknown function (DUF1490); Region: DUF1490; pfam07371
1205675009172	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1205675009173	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1205675009174	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1205675009175	active site
1205675009176	motif I; other site
1205675009177	motif II; other site
1205675009178	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675009179	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675009180	active site
1205675009181	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046, 12775759; Product type e : enzyme
1205675009182	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1205675009183	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1205675009184	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1205675009185	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1205675009186	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1205675009187	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1205675009188	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288
1205675009189	active site clefts [active]
1205675009190	zinc binding site [ion binding]; other site
1205675009191	dimer interface [polypeptide binding]; other site
1205675009192	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675009193	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1205675009194	FAD binding site [chemical binding]; other site
1205675009195	homotetramer interface [polypeptide binding]; other site
1205675009196	substrate binding pocket [chemical binding]; other site
1205675009197	catalytic base [active]
1205675009198	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1205675009199	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026
1205675009200	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1205675009201	Predicted membrane protein [Function unknown]; Region: COG2246
1205675009202	GtrA-like protein; Region: GtrA; pfam04138
1205675009203	Bacterial PH domain; Region: DUF304; pfam03703
1205675009204	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1205675009205	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1205675009206	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1205675009207	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1205675009208	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1205675009209	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1205675009210	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
1205675009211	Maf-like protein; Region: Maf; pfam02545
1205675009212	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1205675009213	active site
1205675009214	dimer interface [polypeptide binding]; other site
1205675009215	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1205675009216	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1205675009217	active site residue [active]
1205675009218	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1205675009219	active site residue [active]
1205675009220	Fe-S metabolism associated domain; Region: SufE; pfam02657
1205675009221	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1205675009222	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1205675009223	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1205675009224	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1205675009225	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1205675009226	carboxyltransferase (CT) interaction site; other site
1205675009227	biotinylation site [posttranslational modification]; other site
1205675009228	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122
1205675009229	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1205675009230	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1205675009231	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1205675009232	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1205675009233	L-lysine aminotransferase; Provisional; Region: PRK08297
1205675009234	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1205675009235	inhibitor-cofactor binding pocket; inhibition site
1205675009236	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675009237	catalytic residue [active]
1205675009238	putative DNA binding site [nucleotide binding]; other site
1205675009239	dimerization interface [polypeptide binding]; other site
1205675009240	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1205675009241	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1205675009242	putative Zn2+ binding site [ion binding]; other site
1205675009243	AsnC family; Region: AsnC_trans_reg; pfam01037
1205675009244	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
1205675009245	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
1205675009246	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1205675009247	tetrameric interface [polypeptide binding]; other site
1205675009248	NAD binding site [chemical binding]; other site
1205675009249	catalytic residues [active]
1205675009250	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
1205675009251	AAA domain; Region: AAA_14; pfam13173
1205675009252	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675009253	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675009254	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1205675009255	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
1205675009256	ATP binding site [chemical binding]; other site
1205675009257	putative Mg++ binding site [ion binding]; other site
1205675009258	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1205675009259	nucleotide binding region [chemical binding]; other site
1205675009260	ATP-binding site [chemical binding]; other site
1205675009261	DEAD/H associated; Region: DEAD_assoc; pfam08494
1205675009262	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1205675009263	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
1205675009264	putative DNA binding site [nucleotide binding]; other site
1205675009265	catalytic residue [active]
1205675009266	putative H2TH interface [polypeptide binding]; other site
1205675009267	putative catalytic residues [active]
1205675009268	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1205675009269	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
1205675009270	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1205675009271	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1205675009272	Sulfatase; Region: Sulfatase; pfam00884
1205675009273	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
1205675009274	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1205675009275	probable active site [active]
1205675009276	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1205675009277	PhoU domain; Region: PhoU; pfam01895
1205675009278	PhoU domain; Region: PhoU; pfam01895
1205675009279	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1205675009280	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
1205675009281	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1205675009282	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1205675009283	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1205675009284	putative active site pocket [active]
1205675009285	dimerization interface [polypeptide binding]; other site
1205675009286	putative catalytic residue [active]
1205675009287	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1205675009288	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
1205675009289	metal binding site [ion binding]; metal-binding site
1205675009290	putative dimer interface [polypeptide binding]; other site
1205675009291	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1205675009292	amidohydrolase; Region: amidohydrolases; TIGR01891
1205675009293	metal binding site [ion binding]; metal-binding site
1205675009294	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1205675009295	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1205675009296	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1205675009297	active site
1205675009298	substrate binding site [chemical binding]; other site
1205675009299	metal binding site [ion binding]; metal-binding site
1205675009300	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1205675009301	active site
1205675009302	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1205675009303	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675009304	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1205675009305	adenosine deaminase; Provisional; Region: PRK09358
1205675009306	active site
1205675009307	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
1205675009308	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1205675009309	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1205675009310	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1205675009311	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1205675009312	active site
1205675009313	catalytic motif [active]
1205675009314	Zn binding site [ion binding]; other site
1205675009315	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
1205675009316	putative Iron-sulfur protein interface [polypeptide binding]; other site
1205675009317	putative proximal heme binding site [chemical binding]; other site
1205675009318	putative SdhD-like interface [polypeptide binding]; other site
1205675009319	putative distal heme binding site [chemical binding]; other site
1205675009320	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
1205675009321	putative Iron-sulfur protein interface [polypeptide binding]; other site
1205675009322	putative proximal heme binding site [chemical binding]; other site
1205675009323	putative SdhC-like subunit interface [polypeptide binding]; other site
1205675009324	putative distal heme binding site [chemical binding]; other site
1205675009325	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
1205675009326	L-aspartate oxidase; Provisional; Region: PRK06175
1205675009327	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1205675009328	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1205675009329	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1205675009330	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1205675009331	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1205675009332	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675009333	S-adenosylmethionine binding site [chemical binding]; other site
1205675009334	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1205675009335	MoaE interaction surface [polypeptide binding]; other site
1205675009336	MoeB interaction surface [polypeptide binding]; other site
1205675009337	thiocarboxylated glycine; other site
1205675009338	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1205675009339	MoaE homodimer interface [polypeptide binding]; other site
1205675009340	MoaD interaction [polypeptide binding]; other site
1205675009341	active site residues [active]
1205675009342	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1205675009343	trimer interface [polypeptide binding]; other site
1205675009344	dimer interface [polypeptide binding]; other site
1205675009345	putative active site [active]
1205675009346	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
1205675009347	aromatic arch; other site
1205675009348	DCoH dimer interaction site [polypeptide binding]; other site
1205675009349	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1205675009350	DCoH tetramer interaction site [polypeptide binding]; other site
1205675009351	substrate binding site [chemical binding]; other site
1205675009352	Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896
1205675009353	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1205675009354	FeS/SAM binding site; other site
1205675009355	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1205675009356	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
1205675009357	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
1205675009358	DNA binding site [nucleotide binding]
1205675009359	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1205675009360	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1205675009361	phosphopeptide binding site; other site
1205675009362	Condensation domain; Region: Condensation; pfam00668
1205675009363	Evidence 2b : Function of strongly homologous gene; PubMedId : 12657046, 12775759; Product type e : enzyme
1205675009364	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
1205675009365	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1205675009366	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1205675009367	DNA binding residues [nucleotide binding]
1205675009368	SnoaL-like domain; Region: SnoaL_2; pfam12680
1205675009369	hypothetical protein; Provisional; Region: PRK06541
1205675009370	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1205675009371	inhibitor-cofactor binding pocket; inhibition site
1205675009372	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675009373	catalytic residue [active]
1205675009374	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1205675009375	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1205675009376	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1205675009377	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675009378	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1205675009379	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1205675009380	active site
1205675009381	dimer interface [polypeptide binding]; other site
1205675009382	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1205675009383	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
1205675009384	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1205675009385	DNA binding residues [nucleotide binding]
1205675009386	dimer interface [polypeptide binding]; other site
1205675009387	metal binding site [ion binding]; metal-binding site
1205675009388	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
1205675009389	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1205675009390	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1205675009391	active site
1205675009392	HIGH motif; other site
1205675009393	dimer interface [polypeptide binding]; other site
1205675009394	KMSKS motif; other site
1205675009395	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675009396	isocitrate dehydrogenase; Validated; Region: PRK08299
1205675009397	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
1205675009398	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1205675009399	homodimer interface [polypeptide binding]; other site
1205675009400	substrate-cofactor binding pocket; other site
1205675009401	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675009402	catalytic residue [active]
1205675009403	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1205675009404	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
1205675009405	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675009406	S-adenosylmethionine binding site [chemical binding]; other site
1205675009407	Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046
1205675009408	Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12657046
1205675009409	PE family; Region: PE; pfam00934
1205675009410	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675009411	PPE family; Region: PPE; pfam00823
1205675009412	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009413	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675009414	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009415	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675009416	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009417	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009418	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009419	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675009420	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009421	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009422	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009423	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675009424	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009425	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009426	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009427	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675009428	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009429	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009430	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009431	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675009432	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009433	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009434	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009435	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1205675009436	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1205675009437	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1205675009438	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1205675009439	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1205675009440	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1205675009441	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
1205675009442	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
1205675009443	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1205675009444	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1205675009445	homodimer interface [polypeptide binding]; other site
1205675009446	NADP binding site [chemical binding]; other site
1205675009447	substrate binding site [chemical binding]; other site
1205675009448	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1205675009449	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
1205675009450	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1205675009451	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
1205675009452	active site
1205675009453	FMN binding site [chemical binding]; other site
1205675009454	substrate binding site [chemical binding]; other site
1205675009455	putative catalytic residue [active]
1205675009456	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1205675009457	phosphate binding site [ion binding]; other site
1205675009458	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1205675009459	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1205675009460	phosphopeptide binding site; other site
1205675009461	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1205675009462	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1205675009463	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1205675009464	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1205675009465	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1205675009466	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
1205675009467	G1 box; other site
1205675009468	GTP/Mg2+ binding site [chemical binding]; other site
1205675009469	G2 box; other site
1205675009470	Switch I region; other site
1205675009471	G3 box; other site
1205675009472	Switch II region; other site
1205675009473	G4 box; other site
1205675009474	G5 box; other site
1205675009475	Protein of unknown function (DUF742); Region: DUF742; pfam05331
1205675009476	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
1205675009477	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1205675009478	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1205675009479	ATP binding site [chemical binding]; other site
1205675009480	Mg2+ binding site [ion binding]; other site
1205675009481	G-X-G motif; other site
1205675009482	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1205675009483	PE family; Region: PE; pfam00934
1205675009484	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
1205675009485	FMN binding site [chemical binding]; other site
1205675009486	dimer interface [polypeptide binding]; other site
1205675009487	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1205675009488	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
1205675009489	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1205675009490	active site
1205675009491	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1205675009492	generic binding surface II; other site
1205675009493	generic binding surface I; other site
1205675009494	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1205675009495	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1205675009496	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1205675009497	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
1205675009498	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1205675009499	active site
1205675009500	motif I; other site
1205675009501	motif II; other site
1205675009502	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
1205675009503	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675009504	substrate binding site [chemical binding]; other site
1205675009505	oxyanion hole (OAH) forming residues; other site
1205675009506	trimer interface [polypeptide binding]; other site
1205675009507	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1205675009508	Amidase; Region: Amidase; pfam01425
1205675009509	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1205675009510	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1205675009511	motif II; other site
1205675009512	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
1205675009513	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
1205675009514	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1205675009515	TPP-binding site [chemical binding]; other site
1205675009516	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1205675009517	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1205675009518	PYR/PP interface [polypeptide binding]; other site
1205675009519	dimer interface [polypeptide binding]; other site
1205675009520	TPP binding site [chemical binding]; other site
1205675009521	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1205675009522	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1205675009523	LytB protein; Region: LYTB; pfam02401
1205675009524	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1205675009525	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1205675009526	substrate binding pocket [chemical binding]; other site
1205675009527	chain length determination region; other site
1205675009528	substrate-Mg2+ binding site; other site
1205675009529	catalytic residues [active]
1205675009530	aspartate-rich region 1; other site
1205675009531	active site lid residues [active]
1205675009532	aspartate-rich region 2; other site
1205675009533	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
1205675009534	putative active site [active]
1205675009535	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1205675009536	enoyl-CoA hydratase; Region: PLN02864
1205675009537	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1205675009538	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
1205675009539	dimer interaction site [polypeptide binding]; other site
1205675009540	substrate-binding tunnel; other site
1205675009541	active site
1205675009542	catalytic site [active]
1205675009543	substrate binding site [chemical binding]; other site
1205675009544	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1205675009545	short chain dehydrogenase; Provisional; Region: PRK07201
1205675009546	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
1205675009547	putative NAD(P) binding site [chemical binding]; other site
1205675009548	active site
1205675009549	putative substrate binding site [chemical binding]; other site
1205675009550	classical (c) SDRs; Region: SDR_c; cd05233
1205675009551	NAD(P) binding site [chemical binding]; other site
1205675009552	active site
1205675009553	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1205675009554	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1205675009555	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675009556	S-adenosylmethionine binding site [chemical binding]; other site
1205675009557	NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653
1205675009558	active site
1205675009559	DNA Polymerase Y-family; Region: PolY_like; cd03468
1205675009560	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1205675009561	DNA binding site [nucleotide binding]
1205675009562	GMP synthase; Reviewed; Region: guaA; PRK00074
1205675009563	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1205675009564	AMP/PPi binding site [chemical binding]; other site
1205675009565	candidate oxyanion hole; other site
1205675009566	catalytic triad [active]
1205675009567	potential glutamine specificity residues [chemical binding]; other site
1205675009568	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1205675009569	ATP Binding subdomain [chemical binding]; other site
1205675009570	Ligand Binding sites [chemical binding]; other site
1205675009571	Dimerization subdomain; other site
1205675009572	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1205675009573	active site lid residues [active]
1205675009574	substrate binding pocket [chemical binding]; other site
1205675009575	catalytic residues [active]
1205675009576	substrate-Mg2+ binding site; other site
1205675009577	aspartate-rich region 1; other site
1205675009578	aspartate-rich region 2; other site
1205675009579	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1205675009580	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1205675009581	substrate binding pocket [chemical binding]; other site
1205675009582	chain length determination region; other site
1205675009583	substrate-Mg2+ binding site; other site
1205675009584	catalytic residues [active]
1205675009585	aspartate-rich region 1; other site
1205675009586	active site lid residues [active]
1205675009587	aspartate-rich region 2; other site
1205675009588	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675009589	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1205675009590	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1205675009591	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1205675009592	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
1205675009593	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1205675009594	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1205675009595	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1205675009596	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1205675009597	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1205675009598	inhibitor-cofactor binding pocket; inhibition site
1205675009599	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675009600	catalytic residue [active]
1205675009601	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
1205675009602	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1205675009603	hypothetical protein; Provisional; Region: PRK07579
1205675009604	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
1205675009605	active site
1205675009606	cosubstrate binding site; other site
1205675009607	substrate binding site [chemical binding]; other site
1205675009608	catalytic site [active]
1205675009609	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675009610	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675009611	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1205675009612	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1205675009613	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1205675009614	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
1205675009615	putative active site [active]
1205675009616	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1205675009617	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1205675009618	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1205675009619	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
1205675009620	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1205675009621	phosphate binding site [ion binding]; other site
1205675009622	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1205675009623	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1205675009624	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1205675009625	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1205675009626	active site
1205675009627	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
1205675009628	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1205675009629	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1205675009630	DNA binding residues [nucleotide binding]
1205675009631	Transcription factor WhiB; Region: Whib; pfam02467
1205675009632	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1205675009633	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1205675009634	ring oligomerisation interface [polypeptide binding]; other site
1205675009635	ATP/Mg binding site [chemical binding]; other site
1205675009636	stacking interactions; other site
1205675009637	hinge regions; other site
1205675009638	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1205675009639	oligomerisation interface [polypeptide binding]; other site
1205675009640	mobile loop; other site
1205675009641	roof hairpin; other site
1205675009642	UGMP family protein; Validated; Region: PRK09604
1205675009643	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1205675009644	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1205675009645	Coenzyme A binding pocket [chemical binding]; other site
1205675009646	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
1205675009647	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367
1205675009648	alanine racemase; Reviewed; Region: alr; PRK00053
1205675009649	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1205675009650	active site
1205675009651	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1205675009652	dimer interface [polypeptide binding]; other site
1205675009653	substrate binding site [chemical binding]; other site
1205675009654	catalytic residues [active]
1205675009655	Evidence 4 : Homologs of previously reported genes of unknown function
1205675009656	Evidence 4 : Homologs of previously reported genes of unknown function
1205675009657	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675009658	PPE family; Region: PPE; pfam00823
1205675009659	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675009660	PPE family; Region: PPE; pfam00823
1205675009661	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1205675009662	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675009663	Walker A motif; other site
1205675009664	ATP binding site [chemical binding]; other site
1205675009665	Walker B motif; other site
1205675009666	arginine finger; other site
1205675009667	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675009668	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675009669	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675009670	PPE family; Region: PPE; pfam00823
1205675009671	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675009672	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675009673	PPE family; Region: PPE; pfam00823
1205675009674	PPE family; Region: PPE; pfam00823
1205675009675	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675009676	PPE family; Region: PPE; pfam00823
1205675009677	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
1205675009678	Evidence 2b : Function of strongly homologous gene; Product type e : enzyme
1205675009679	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1205675009680	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1205675009681	MULE transposase domain; Region: MULE; pfam10551
1205675009682	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
1205675009683	Integrase core domain; Region: rve_3; cl15866
1205675009684	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1205675009685	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675009686	catalytic residue [active]
1205675009687	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
1205675009688	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1205675009689	putative substrate binding site [chemical binding]; other site
1205675009690	putative ATP binding site [chemical binding]; other site
1205675009691	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1205675009692	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1205675009693	glutaminase active site [active]
1205675009694	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1205675009695	dimer interface [polypeptide binding]; other site
1205675009696	active site
1205675009697	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1205675009698	dimer interface [polypeptide binding]; other site
1205675009699	active site
1205675009700	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
1205675009701	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
1205675009702	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1205675009703	active site
1205675009704	substrate binding site [chemical binding]; other site
1205675009705	metal binding site [ion binding]; metal-binding site
1205675009706	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1205675009707	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1205675009708	23S rRNA interface [nucleotide binding]; other site
1205675009709	L3 interface [polypeptide binding]; other site
1205675009710	Proteins of 100 residues with WXG; Region: WXG100; cl02005
1205675009711	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1205675009712	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
1205675009713	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1205675009714	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1205675009715	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1205675009716	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1205675009717	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1205675009718	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1205675009719	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1205675009720	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1205675009721	active site
1205675009722	catalytic residues [active]
1205675009723	Protein of unknown function (DUF690); Region: DUF690; pfam05108
1205675009724	Cutinase; Region: Cutinase; pfam01083
1205675009725	Cutinase; Region: Cutinase; pfam01083
1205675009726	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1205675009727	Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101
1205675009728	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1205675009729	dimerization interface 3.5A [polypeptide binding]; other site
1205675009730	active site
1205675009731	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1205675009732	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1205675009733	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1205675009734	alphaNTD - beta interaction site [polypeptide binding]; other site
1205675009735	alphaNTD homodimer interface [polypeptide binding]; other site
1205675009736	alphaNTD - beta' interaction site [polypeptide binding]; other site
1205675009737	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1205675009738	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1205675009739	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1205675009740	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1205675009741	RNA binding surface [nucleotide binding]; other site
1205675009742	30S ribosomal protein S11; Validated; Region: PRK05309
1205675009743	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1205675009744	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1205675009745	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1205675009746	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1205675009747	rRNA binding site [nucleotide binding]; other site
1205675009748	predicted 30S ribosome binding site; other site
1205675009749	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1205675009750	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
1205675009751	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1205675009752	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1205675009753	NAD binding site [chemical binding]; other site
1205675009754	substrate binding site [chemical binding]; other site
1205675009755	homodimer interface [polypeptide binding]; other site
1205675009756	active site
1205675009757	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1205675009758	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675009759	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675009760	active site
1205675009761	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1205675009762	extended (e) SDRs; Region: SDR_e; cd08946
1205675009763	NAD(P) binding site [chemical binding]; other site
1205675009764	active site
1205675009765	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
1205675009766	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
1205675009767	active site
1205675009768	catalytic residues [active]
1205675009769	metal binding site [ion binding]; metal-binding site
1205675009770	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1205675009771	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1205675009772	PYR/PP interface [polypeptide binding]; other site
1205675009773	dimer interface [polypeptide binding]; other site
1205675009774	TPP binding site [chemical binding]; other site
1205675009775	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1205675009776	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1205675009777	TPP-binding site [chemical binding]; other site
1205675009778	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1205675009779	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
1205675009780	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675009781	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1205675009782	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675009783	metabolite-proton symporter; Region: 2A0106; TIGR00883
1205675009784	putative substrate translocation pore; other site
1205675009785	PE family; Region: PE; pfam00934
1205675009786	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675009787	PPE family; Region: PPE; pfam00823
1205675009788	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675009789	patatin-related protein; Region: TIGR03607
1205675009790	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1205675009791	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1205675009792	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
1205675009793	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
1205675009794	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
1205675009795	LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041
1205675009796	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1205675009797	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1205675009798	short chain dehydrogenase; Provisional; Region: PRK05875
1205675009799	classical (c) SDRs; Region: SDR_c; cd05233
1205675009800	NAD(P) binding site [chemical binding]; other site
1205675009801	active site
1205675009802	Predicted membrane protein [Function unknown]; Region: COG2259
1205675009803	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1205675009804	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1205675009805	Predicted transcriptional regulators [Transcription]; Region: COG1695
1205675009806	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1205675009807	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
1205675009808	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1205675009809	active site
1205675009810	homotetramer interface [polypeptide binding]; other site
1205675009811	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675009812	mce related protein; Region: MCE; pfam02470
1205675009813	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675009814	mce related protein; Region: MCE; pfam02470
1205675009815	mce related protein; Region: MCE; pfam02470
1205675009816	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675009817	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1205675009818	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675009819	mce related protein; Region: MCE; pfam02470
1205675009820	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675009821	mce related protein; Region: MCE; pfam02470
1205675009822	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1205675009823	mce related protein; Region: MCE; pfam02470
1205675009824	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1205675009825	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1205675009826	Permease; Region: Permease; pfam02405
1205675009827	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1205675009828	Permease; Region: Permease; pfam02405
1205675009829	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
1205675009830	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675009831	NAD(P) binding site [chemical binding]; other site
1205675009832	active site
1205675009833	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1205675009834	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
1205675009835	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675009836	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
1205675009837	FAD binding site [chemical binding]; other site
1205675009838	substrate binding site [chemical binding]; other site
1205675009839	catalytic base [active]
1205675009840	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675009841	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1205675009842	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675009843	active site
1205675009844	acyl-CoA synthetase; Validated; Region: PRK07867
1205675009845	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
1205675009846	acyl-activating enzyme (AAE) consensus motif; other site
1205675009847	putative AMP binding site [chemical binding]; other site
1205675009848	putative active site [active]
1205675009849	putative CoA binding site [chemical binding]; other site
1205675009850	PE family; Region: PE; pfam00934
1205675009851	PE family; Region: PE; pfam00934
1205675009852	hypothetical protein; Validated; Region: PRK07586
1205675009853	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1205675009854	PYR/PP interface [polypeptide binding]; other site
1205675009855	dimer interface [polypeptide binding]; other site
1205675009856	TPP binding site [chemical binding]; other site
1205675009857	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
1205675009858	TPP-binding site [chemical binding]; other site
1205675009859	dimer interface [polypeptide binding]; other site
1205675009860	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1205675009861	acyl-CoA synthetase; Validated; Region: PRK07798
1205675009862	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675009863	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
1205675009864	acyl-activating enzyme (AAE) consensus motif; other site
1205675009865	acyl-activating enzyme (AAE) consensus motif; other site
1205675009866	putative AMP binding site [chemical binding]; other site
1205675009867	putative active site [active]
1205675009868	putative CoA binding site [chemical binding]; other site
1205675009869	enoyl-CoA hydratase; Provisional; Region: PRK07799
1205675009870	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675009871	substrate binding site [chemical binding]; other site
1205675009872	oxyanion hole (OAH) forming residues; other site
1205675009873	trimer interface [polypeptide binding]; other site
1205675009874	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1205675009875	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675009876	Cytochrome P450; Region: p450; cl12078
1205675009877	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
1205675009878	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1205675009879	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
1205675009880	DUF35 OB-fold domain; Region: DUF35; pfam01796
1205675009881	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
1205675009882	DUF35 OB-fold domain; Region: DUF35; pfam01796
1205675009883	lipid-transfer protein; Provisional; Region: PRK07937
1205675009884	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1205675009885	active site
1205675009886	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
1205675009887	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1205675009888	active site
1205675009889	NHL repeat; Region: NHL; pfam01436
1205675009890	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1205675009891	NHL repeat; Region: NHL; pfam01436
1205675009892	NHL repeat; Region: NHL; pfam01436
1205675009893	NHL repeat; Region: NHL; pfam01436
1205675009894	NHL repeat; Region: NHL; pfam01436
1205675009895	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1205675009896	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1205675009897	trimer interface [polypeptide binding]; other site
1205675009898	putative metal binding site [ion binding]; other site
1205675009899	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1205675009900	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
1205675009901	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
1205675009902	short chain dehydrogenase; Provisional; Region: PRK07890
1205675009903	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675009904	NAD(P) binding site [chemical binding]; other site
1205675009905	active site
1205675009906	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675009907	PPE family; Region: PPE; pfam00823
1205675009908	Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484
1205675009909	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675009910	PPE family; Region: PPE; pfam00823
1205675009911	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009912	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675009913	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
1205675009914	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
1205675009915	active site
1205675009916	catalytic residues [active]
1205675009917	metal binding site [ion binding]; metal-binding site
1205675009918	DmpG-like communication domain; Region: DmpG_comm; pfam07836
1205675009919	acetaldehyde dehydrogenase; Validated; Region: PRK08300
1205675009920	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1205675009921	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
1205675009922	2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971
1205675009923	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
1205675009924	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1205675009925	enoyl-CoA hydratase; Region: PLN02864
1205675009926	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1205675009927	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
1205675009928	dimer interaction site [polypeptide binding]; other site
1205675009929	substrate-binding tunnel; other site
1205675009930	active site
1205675009931	catalytic site [active]
1205675009932	substrate binding site [chemical binding]; other site
1205675009933	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675009934	PPE family; Region: PPE; pfam00823
1205675009935	PE-PPE domain; Region: PE-PPE; pfam08237
1205675009936	lipid-transfer protein; Provisional; Region: PRK07855
1205675009937	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1205675009938	active site
1205675009939	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
1205675009940	putative active site [active]
1205675009941	putative catalytic site [active]
1205675009942	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1205675009943	active site
1205675009944	catalytic site [active]
1205675009945	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
1205675009946	DUF35 OB-fold domain; Region: DUF35; pfam01796
1205675009947	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675009948	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675009949	active site
1205675009950	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675009951	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1205675009952	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675009953	active site
1205675009954	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675009955	Cytochrome P450; Region: p450; cl12078
1205675009956	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
1205675009957	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1205675009958	dimer interface [polypeptide binding]; other site
1205675009959	active site
1205675009960	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1205675009961	short chain dehydrogenase; Provisional; Region: PRK07791
1205675009962	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
1205675009963	homodimer interface [polypeptide binding]; other site
1205675009964	NAD binding site [chemical binding]; other site
1205675009965	active site
1205675009966	short chain dehydrogenase; Provisional; Region: PRK07856
1205675009967	classical (c) SDRs; Region: SDR_c; cd05233
1205675009968	NAD(P) binding site [chemical binding]; other site
1205675009969	active site
1205675009970	enoyl-CoA hydratase; Provisional; Region: PRK06495
1205675009971	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675009972	substrate binding site [chemical binding]; other site
1205675009973	oxyanion hole (OAH) forming residues; other site
1205675009974	trimer interface [polypeptide binding]; other site
1205675009975	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1205675009976	Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057
1205675009977	Nitronate monooxygenase; Region: NMO; pfam03060
1205675009978	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1205675009979	FMN binding site [chemical binding]; other site
1205675009980	substrate binding site [chemical binding]; other site
1205675009981	putative catalytic residue [active]
1205675009982	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1205675009983	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
1205675009984	putative di-iron ligands [ion binding]; other site
1205675009985	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1205675009986	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1205675009987	FAD binding pocket [chemical binding]; other site
1205675009988	FAD binding motif [chemical binding]; other site
1205675009989	phosphate binding motif [ion binding]; other site
1205675009990	beta-alpha-beta structure motif; other site
1205675009991	NAD(p) ribose binding residues [chemical binding]; other site
1205675009992	NAD binding pocket [chemical binding]; other site
1205675009993	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1205675009994	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1205675009995	catalytic loop [active]
1205675009996	iron binding site [ion binding]; other site
1205675009997	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1205675009998	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1205675009999	putative active site [active]
1205675010000	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
1205675010001	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1205675010002	dimer interface [polypeptide binding]; other site
1205675010003	active site
1205675010004	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675010005	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675010006	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675010007	PPE family; Region: PPE; pfam00823
1205675010008	Pentapeptide repeats (8 copies); Region: Pentapeptide_2; pfam01469
1205675010009	short chain dehydrogenase; Provisional; Region: PRK07831
1205675010010	classical (c) SDRs; Region: SDR_c; cd05233
1205675010011	NAD(P) binding site [chemical binding]; other site
1205675010012	active site
1205675010013	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675010014	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675010015	active site
1205675010016	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
1205675010017	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1205675010018	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1205675010019	acyl-activating enzyme (AAE) consensus motif; other site
1205675010020	acyl-activating enzyme (AAE) consensus motif; other site
1205675010021	putative AMP binding site [chemical binding]; other site
1205675010022	putative active site [active]
1205675010023	putative CoA binding site [chemical binding]; other site
1205675010024	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675010025	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675010026	active site
1205675010027	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675010028	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1205675010029	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675010030	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675010031	active site
1205675010032	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675010033	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1205675010034	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675010035	active site
1205675010036	aspartate aminotransferase; Provisional; Region: PRK05764
1205675010037	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1205675010038	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675010039	homodimer interface [polypeptide binding]; other site
1205675010040	catalytic residue [active]
1205675010041	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1205675010042	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1205675010043	putative active site [active]
1205675010044	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1205675010045	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
1205675010046	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
1205675010047	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
1205675010048	active site
1205675010049	Fe binding site [ion binding]; other site
1205675010050	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
1205675010051	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1205675010052	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675010053	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
1205675010054	Flavin binding site [chemical binding]; other site
1205675010055	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1205675010056	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1205675010057	FAD binding pocket [chemical binding]; other site
1205675010058	FAD binding motif [chemical binding]; other site
1205675010059	phosphate binding motif [ion binding]; other site
1205675010060	beta-alpha-beta structure motif; other site
1205675010061	NAD(p) ribose binding residues [chemical binding]; other site
1205675010062	NAD binding pocket [chemical binding]; other site
1205675010063	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1205675010064	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1205675010065	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1205675010066	catalytic loop [active]
1205675010067	iron binding site [ion binding]; other site
1205675010068	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675010069	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675010070	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1205675010071	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675010072	active site
1205675010073	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675010074	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675010075	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1205675010076	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1205675010077	DNA binding site [nucleotide binding]
1205675010078	domain linker motif; other site
1205675010079	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
1205675010080	putative dimerization interface [polypeptide binding]; other site
1205675010081	putative ligand binding site [chemical binding]; other site
1205675010082	PknH-like extracellular domain; Region: PknH_C; pfam14032
1205675010083	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1205675010084	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1205675010085	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1205675010086	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1205675010087	transmembrane helices; other site
1205675010088	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1205675010089	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1205675010090	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1205675010091	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1205675010092	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1205675010093	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1205675010094	active site
1205675010095	HIGH motif; other site
1205675010096	nucleotide binding site [chemical binding]; other site
1205675010097	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1205675010098	KMSKS motif; other site
1205675010099	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1205675010100	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1205675010101	homotrimer interaction site [polypeptide binding]; other site
1205675010102	zinc binding site [ion binding]; other site
1205675010103	CDP-binding sites; other site
1205675010104	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1205675010105	substrate binding site; other site
1205675010106	dimer interface; other site
1205675010107	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1205675010108	DNA repair protein RadA; Provisional; Region: PRK11823
1205675010109	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1205675010110	Walker A motif/ATP binding site; other site
1205675010111	ATP binding site [chemical binding]; other site
1205675010112	Walker B motif; other site
1205675010113	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1205675010114	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
1205675010115	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1205675010116	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
1205675010117	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
1205675010118	active site clefts [active]
1205675010119	zinc binding site [ion binding]; other site
1205675010120	dimer interface [polypeptide binding]; other site
1205675010121	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1205675010122	endonuclease III; Region: ENDO3c; smart00478
1205675010123	minor groove reading motif; other site
1205675010124	helix-hairpin-helix signature motif; other site
1205675010125	substrate binding pocket [chemical binding]; other site
1205675010126	active site
1205675010127	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1205675010128	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675010129	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1205675010130	catalytic site [active]
1205675010131	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1205675010132	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1205675010133	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1205675010134	Ami_2 domain; Region: Ami_2; smart00644
1205675010135	amidase catalytic site [active]
1205675010136	Zn binding residues [ion binding]; other site
1205675010137	substrate binding site [chemical binding]; other site
1205675010138	PE family; Region: PE; pfam00934
1205675010139	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1205675010140	Clp amino terminal domain; Region: Clp_N; pfam02861
1205675010141	Clp amino terminal domain; Region: Clp_N; pfam02861
1205675010142	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675010143	Walker A motif; other site
1205675010144	ATP binding site [chemical binding]; other site
1205675010145	Walker B motif; other site
1205675010146	arginine finger; other site
1205675010147	UvrB/uvrC motif; Region: UVR; pfam02151
1205675010148	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675010149	Walker A motif; other site
1205675010150	ATP binding site [chemical binding]; other site
1205675010151	Walker B motif; other site
1205675010152	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1205675010153	Lsr2; Region: Lsr2; pfam11774
1205675010154	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1205675010155	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1205675010156	dimer interface [polypeptide binding]; other site
1205675010157	putative anticodon binding site; other site
1205675010158	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1205675010159	motif 1; other site
1205675010160	dimer interface [polypeptide binding]; other site
1205675010161	active site
1205675010162	motif 2; other site
1205675010163	motif 3; other site
1205675010164	pantothenate kinase; Reviewed; Region: PRK13318
1205675010165	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1205675010166	tetramerization interface [polypeptide binding]; other site
1205675010167	active site
1205675010168	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1205675010169	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1205675010170	active site
1205675010171	ATP-binding site [chemical binding]; other site
1205675010172	pantoate-binding site; other site
1205675010173	HXXH motif; other site
1205675010174	Rossmann-like domain; Region: Rossmann-like; pfam10727
1205675010175	Uncharacterized conserved protein [Function unknown]; Region: COG5495
1205675010176	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
1205675010177	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
1205675010178	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1205675010179	catalytic center binding site [active]
1205675010180	ATP binding site [chemical binding]; other site
1205675010181	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1205675010182	homooctamer interface [polypeptide binding]; other site
1205675010183	active site
1205675010184	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1205675010185	dihydropteroate synthase; Region: DHPS; TIGR01496
1205675010186	substrate binding pocket [chemical binding]; other site
1205675010187	dimer interface [polypeptide binding]; other site
1205675010188	inhibitor binding site; inhibition site
1205675010189	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1205675010190	homodecamer interface [polypeptide binding]; other site
1205675010191	GTP cyclohydrolase I; Provisional; Region: PLN03044
1205675010192	active site
1205675010193	putative catalytic site residues [active]
1205675010194	zinc binding site [ion binding]; other site
1205675010195	GTP-CH-I/GFRP interaction surface; other site
1205675010196	FtsH Extracellular; Region: FtsH_ext; pfam06480
1205675010197	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1205675010198	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675010199	Walker A motif; other site
1205675010200	ATP binding site [chemical binding]; other site
1205675010201	Walker B motif; other site
1205675010202	arginine finger; other site
1205675010203	Peptidase family M41; Region: Peptidase_M41; pfam01434
1205675010204	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
1205675010205	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675010206	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1205675010207	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1205675010208	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1205675010209	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1205675010210	Proteins of 100 residues with WXG; Region: WXG100; cl02005
1205675010211	Proteins of 100 residues with WXG; Region: WXG100; cl02005
1205675010212	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675010213	PPE family; Region: PPE; pfam00823
1205675010214	PE family; Region: PE; pfam00934
1205675010215	Uncharacterized conserved protein [Function unknown]; Region: COG2968
1205675010216	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1205675010217	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1205675010218	active site
1205675010219	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1205675010220	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1205675010221	Ligand Binding Site [chemical binding]; other site
1205675010222	Uncharacterized conserved protein [Function unknown]; Region: COG5282
1205675010223	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
1205675010224	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113
1205675010225	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1205675010226	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1205675010227	dimer interface [polypeptide binding]; other site
1205675010228	substrate binding site [chemical binding]; other site
1205675010229	metal binding sites [ion binding]; metal-binding site
1205675010230	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899
1205675010231	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1205675010232	Ligand binding site; other site
1205675010233	Putative Catalytic site; other site
1205675010234	DXD motif; other site
1205675010235	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
1205675010236	Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285
1205675010237	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1205675010238	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675010239	NAD(P) binding site [chemical binding]; other site
1205675010240	active site
1205675010241	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675010242	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1205675010243	Integrase core domain; Region: rve; pfam00665
1205675010244	Integrase core domain; Region: rve_3; cl15866
1205675010245	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1205675010246	transposase; Provisional; Region: PRK06526
1205675010247	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675010248	Walker A motif; other site
1205675010249	ATP binding site [chemical binding]; other site
1205675010250	Walker B motif; other site
1205675010251	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pcp : putative cell process
1205675010252	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pcp : putative cell process
1205675010253	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
1205675010254	DNA polymerase III subunit delta'; Validated; Region: PRK07940
1205675010255	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1205675010256	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1205675010257	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1205675010258	dimerization interface [polypeptide binding]; other site
1205675010259	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1205675010260	cyclase homology domain; Region: CHD; cd07302
1205675010261	nucleotidyl binding site; other site
1205675010262	metal binding site [ion binding]; metal-binding site
1205675010263	dimer interface [polypeptide binding]; other site
1205675010264	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1205675010265	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1205675010266	active site
1205675010267	interdomain interaction site; other site
1205675010268	putative metal-binding site [ion binding]; other site
1205675010269	nucleotide binding site [chemical binding]; other site
1205675010270	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
1205675010271	domain I; other site
1205675010272	phosphate binding site [ion binding]; other site
1205675010273	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1205675010274	domain II; other site
1205675010275	domain III; other site
1205675010276	nucleotide binding site [chemical binding]; other site
1205675010277	DNA binding groove [nucleotide binding]
1205675010278	catalytic site [active]
1205675010279	domain IV; other site
1205675010280	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1205675010281	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1205675010282	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1205675010283	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1205675010284	DNA-binding site [nucleotide binding]; DNA binding site
1205675010285	RNA-binding motif; other site
1205675010286	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
1205675010287	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1205675010288	ATP binding site [chemical binding]; other site
1205675010289	putative Mg++ binding site [ion binding]; other site
1205675010290	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1205675010291	nucleotide binding region [chemical binding]; other site
1205675010292	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
1205675010293	PE family; Region: PE; pfam00934
1205675010294	PE family; Region: PE; pfam00934
1205675010295	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
1205675010296	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1205675010297	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1205675010298	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1205675010299	Walker A motif; other site
1205675010300	hexamer interface [polypeptide binding]; other site
1205675010301	ATP binding site [chemical binding]; other site
1205675010302	Walker B motif; other site
1205675010303	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
1205675010304	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1205675010305	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1205675010306	motif II; other site
1205675010307	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1205675010308	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1205675010309	Walker A/P-loop; other site
1205675010310	ATP binding site [chemical binding]; other site
1205675010311	Q-loop/lid; other site
1205675010312	ABC transporter signature motif; other site
1205675010313	Walker B; other site
1205675010314	D-loop; other site
1205675010315	H-loop/switch region; other site
1205675010316	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1205675010317	Walker A/P-loop; other site
1205675010318	ATP binding site [chemical binding]; other site
1205675010319	Q-loop/lid; other site
1205675010320	ABC transporter signature motif; other site
1205675010321	Walker B; other site
1205675010322	D-loop; other site
1205675010323	H-loop/switch region; other site
1205675010324	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1205675010325	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1205675010326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675010327	ABC-ATPase subunit interface; other site
1205675010328	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1205675010329	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675010330	dimer interface [polypeptide binding]; other site
1205675010331	conserved gate region; other site
1205675010332	ABC-ATPase subunit interface; other site
1205675010333	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1205675010334	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1205675010335	acetyl-CoA synthetase; Provisional; Region: PRK00174
1205675010336	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1205675010337	active site
1205675010338	CoA binding site [chemical binding]; other site
1205675010339	acyl-activating enzyme (AAE) consensus motif; other site
1205675010340	AMP binding site [chemical binding]; other site
1205675010341	acetate binding site [chemical binding]; other site
1205675010342	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
1205675010343	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1205675010344	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1205675010345	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1205675010346	putative active site [active]
1205675010347	putative CoA binding site [chemical binding]; other site
1205675010348	nudix motif; other site
1205675010349	metal binding site [ion binding]; metal-binding site
1205675010350	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1205675010351	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1205675010352	catalytic residues [active]
1205675010353	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1205675010354	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1205675010355	minor groove reading motif; other site
1205675010356	helix-hairpin-helix signature motif; other site
1205675010357	substrate binding pocket [chemical binding]; other site
1205675010358	active site
1205675010359	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1205675010360	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1205675010361	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1205675010362	ligand binding site [chemical binding]; other site
1205675010363	flexible hinge region; other site
1205675010364	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1205675010365	putative switch regulator; other site
1205675010366	non-specific DNA interactions [nucleotide binding]; other site
1205675010367	DNA binding site [nucleotide binding]
1205675010368	sequence specific DNA binding site [nucleotide binding]; other site
1205675010369	putative cAMP binding site [chemical binding]; other site
1205675010370	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1205675010371	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1205675010372	homotrimer interaction site [polypeptide binding]; other site
1205675010373	putative active site [active]
1205675010374	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
1205675010375	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1205675010376	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1205675010377	P loop; other site
1205675010378	Nucleotide binding site [chemical binding]; other site
1205675010379	DTAP/Switch II; other site
1205675010380	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1205675010381	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1205675010382	DTAP/Switch II; other site
1205675010383	Switch I; other site
1205675010384	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1205675010385	Transcription factor WhiB; Region: Whib; pfam02467
1205675010386	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1205675010387	Transglycosylase; Region: Transgly; pfam00912
1205675010388	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1205675010389	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1205675010390	phosphodiesterase YaeI; Provisional; Region: PRK11340
1205675010391	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1205675010392	putative active site [active]
1205675010393	putative metal binding site [ion binding]; other site
1205675010394	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1205675010395	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1205675010396	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1205675010397	catalytic residue [active]
1205675010398	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1205675010399	Cytochrome P450; Region: p450; cl12078
1205675010400	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1205675010401	anti sigma factor interaction site; other site
1205675010402	regulatory phosphorylation site [posttranslational modification]; other site
1205675010403	Uncharacterized conserved protein [Function unknown]; Region: COG1610
1205675010404	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1205675010405	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
1205675010406	MoxR-like ATPases [General function prediction only]; Region: COG0714
1205675010407	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675010408	Walker A motif; other site
1205675010409	ATP binding site [chemical binding]; other site
1205675010410	Walker B motif; other site
1205675010411	arginine finger; other site
1205675010412	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1205675010413	Protein of unknown function DUF58; Region: DUF58; pfam01882
1205675010414	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
1205675010415	Predicted membrane protein/domain [Function unknown]; Region: COG1714
1205675010416	glycerol kinase; Provisional; Region: glpK; PRK00047
1205675010417	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1205675010418	nucleotide binding site [chemical binding]; other site
1205675010419	Mycobacterium tuberculosis PIN domain family; Region: Mtu_PIN_fam; TIGR00028
1205675010420	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1205675010421	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675010422	S-adenosylmethionine binding site [chemical binding]; other site
1205675010423	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1205675010424	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1205675010425	catalytic residue [active]
1205675010426	Uncharacterized conserved protein [Function unknown]; Region: COG4301
1205675010427	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
1205675010428	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
1205675010429	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1205675010430	putative active site [active]
1205675010431	putative dimer interface [polypeptide binding]; other site
1205675010432	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
1205675010433	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1205675010434	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
1205675010435	PknH-like extracellular domain; Region: PknH_C; pfam14032
1205675010436	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
1205675010437	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1205675010438	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1205675010439	aspartate kinase; Reviewed; Region: PRK06635
1205675010440	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1205675010441	putative nucleotide binding site [chemical binding]; other site
1205675010442	putative catalytic residues [active]
1205675010443	putative Mg ion binding site [ion binding]; other site
1205675010444	putative aspartate binding site [chemical binding]; other site
1205675010445	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1205675010446	putative allosteric regulatory site; other site
1205675010447	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1205675010448	putative allosteric regulatory residue; other site
1205675010449	2-isopropylmalate synthase; Validated; Region: PRK03739
1205675010450	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1205675010451	active site
1205675010452	catalytic residues [active]
1205675010453	metal binding site [ion binding]; metal-binding site
1205675010454	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1205675010455	DNA polymerase III subunit epsilon; Provisional; Region: PRK06063
1205675010456	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1205675010457	active site
1205675010458	catalytic site [active]
1205675010459	substrate binding site [chemical binding]; other site
1205675010460	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1205675010461	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1205675010462	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1205675010463	catalytic triad [active]
1205675010464	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1205675010465	putative active site [active]
1205675010466	recombination protein RecR; Reviewed; Region: recR; PRK00076
1205675010467	RecR protein; Region: RecR; pfam02132
1205675010468	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1205675010469	putative active site [active]
1205675010470	putative metal-binding site [ion binding]; other site
1205675010471	tetramer interface [polypeptide binding]; other site
1205675010472	hypothetical protein; Validated; Region: PRK00153
1205675010473	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1205675010474	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1205675010475	active site
1205675010476	metal binding site [ion binding]; metal-binding site
1205675010477	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
1205675010478	hydrophobic ligand binding site; other site
1205675010479	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1205675010480	FAD binding domain; Region: FAD_binding_4; pfam01565
1205675010481	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1205675010482	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675010483	S-adenosylmethionine binding site [chemical binding]; other site
1205675010484	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14952
1205675010485	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675010486	Walker A motif; other site
1205675010487	ATP binding site [chemical binding]; other site
1205675010488	Walker B motif; other site
1205675010489	arginine finger; other site
1205675010490	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1205675010491	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
1205675010492	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1205675010493	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1205675010494	catalytic residue [active]
1205675010495	Cutinase; Region: Cutinase; pfam01083
1205675010496	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
1205675010497	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675010498	NAD(P) binding site [chemical binding]; other site
1205675010499	active site
1205675010500	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1205675010501	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262
1205675010502	putative NAD(P) binding site [chemical binding]; other site
1205675010503	catalytic Zn binding site [ion binding]; other site
1205675010504	Uncharacterized conserved protein [Function unknown]; Region: COG3349
1205675010505	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
1205675010506	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1205675010507	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1205675010508	putative substrate translocation pore; other site
1205675010509	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1205675010510	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1205675010511	ligand binding site [chemical binding]; other site
1205675010512	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1205675010513	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
1205675010514	active site
1205675010515	nucleophile elbow; other site
1205675010516	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964
1205675010517	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1205675010518	FeS/SAM binding site; other site
1205675010519	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1205675010520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1205675010521	S-adenosylmethionine binding site [chemical binding]; other site
1205675010522	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
1205675010523	nucleotide binding site [chemical binding]; other site
1205675010524	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
1205675010525	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
1205675010526	active site
1205675010527	DNA binding site [nucleotide binding]
1205675010528	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
1205675010529	DNA binding site [nucleotide binding]
1205675010530	Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827
1205675010531	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_5; cd04662
1205675010532	nudix motif; other site
1205675010533	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1205675010534	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1205675010535	Uncharacterized conserved protein [Function unknown]; Region: COG1839
1205675010536	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1205675010537	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1205675010538	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1205675010539	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1205675010540	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1205675010541	Uncharacterized conserved protein [Function unknown]; Region: COG3610
1205675010542	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675010543	PPE family; Region: PPE; pfam00823
1205675010544	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1205675010545	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1205675010546	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
1205675010547	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1205675010548	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1205675010549	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1205675010550	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1205675010551	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1205675010552	dimerization interface [polypeptide binding]; other site
1205675010553	putative DNA binding site [nucleotide binding]; other site
1205675010554	putative Zn2+ binding site [ion binding]; other site
1205675010555	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467
1205675010556	PIN domain; Region: PIN_3; pfam13470
1205675010557	DNA binding domain, excisionase family; Region: excise; TIGR01764
1205675010558	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1205675010559	active site
1205675010560	Int/Topo IB signature motif; other site
1205675010561	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1205675010562	nucleoside/Zn binding site; other site
1205675010563	dimer interface [polypeptide binding]; other site
1205675010564	catalytic motif [active]
1205675010565	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
1205675010566	prephenate dehydrogenase; Validated; Region: PRK06545
1205675010567	prephenate dehydrogenase; Validated; Region: PRK08507
1205675010568	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3554
1205675010569	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1205675010570	ABC-ATPase subunit interface; other site
1205675010571	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
1205675010572	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1205675010573	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1205675010574	Walker A/P-loop; other site
1205675010575	ATP binding site [chemical binding]; other site
1205675010576	Q-loop/lid; other site
1205675010577	ABC transporter signature motif; other site
1205675010578	Walker B; other site
1205675010579	D-loop; other site
1205675010580	H-loop/switch region; other site
1205675010581	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1205675010582	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
1205675010583	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
1205675010584	putative active site [active]
1205675010585	putative substrate binding site [chemical binding]; other site
1205675010586	ATP binding site [chemical binding]; other site
1205675010587	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
1205675010588	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1205675010589	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
1205675010590	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1205675010591	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1205675010592	dimerization interface [polypeptide binding]; other site
1205675010593	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1205675010594	dimer interface [polypeptide binding]; other site
1205675010595	phosphorylation site [posttranslational modification]
1205675010596	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1205675010597	ATP binding site [chemical binding]; other site
1205675010598	Mg2+ binding site [ion binding]; other site
1205675010599	G-X-G motif; other site
1205675010600	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1205675010601	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1205675010602	active site
1205675010603	phosphorylation site [posttranslational modification]
1205675010604	intermolecular recognition site; other site
1205675010605	dimerization interface [polypeptide binding]; other site
1205675010606	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1205675010607	DNA binding site [nucleotide binding]
1205675010608	Photosystem II reaction centre W protein (PsbW); Region: PsbW; cl06243
1205675010609	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675010610	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1205675010611	SnoaL-like domain; Region: SnoaL_2; pfam12680
1205675010612	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1205675010613	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1205675010614	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1205675010615	homodimer interface [polypeptide binding]; other site
1205675010616	catalytic residue [active]
1205675010617	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1205675010618	TIGR03086 family protein; Region: TIGR03086
1205675010619	enoyl-CoA hydratase; Provisional; Region: PRK06142
1205675010620	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1205675010621	substrate binding site [chemical binding]; other site
1205675010622	oxyanion hole (OAH) forming residues; other site
1205675010623	trimer interface [polypeptide binding]; other site
1205675010624	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1205675010625	Beta-lactamase; Region: Beta-lactamase; pfam00144
1205675010626	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1205675010627	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1205675010628	active site
1205675010629	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1205675010630	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1205675010631	NAD(P) binding site [chemical binding]; other site
1205675010632	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1205675010633	cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976
1205675010634	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1205675010635	catalytic residue [active]
1205675010636	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
1205675010637	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1205675010638	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1205675010639	Walker A/P-loop; other site
1205675010640	ATP binding site [chemical binding]; other site
1205675010641	Q-loop/lid; other site
1205675010642	ABC transporter signature motif; other site
1205675010643	Walker B; other site
1205675010644	D-loop; other site
1205675010645	H-loop/switch region; other site
1205675010646	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1205675010647	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1205675010648	active site
1205675010649	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1205675010650	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1205675010651	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1205675010652	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
1205675010653	NAD binding site [chemical binding]; other site
1205675010654	substrate binding site [chemical binding]; other site
1205675010655	active site
1205675010656	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1205675010657	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1205675010658	active site
1205675010659	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1205675010660	Peptidase family M23; Region: Peptidase_M23; pfam01551
1205675010661	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1205675010662	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
1205675010663	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892
1205675010664	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1205675010665	Predicted membrane protein [Function unknown]; Region: COG2246
1205675010666	GtrA-like protein; Region: GtrA; pfam04138
1205675010667	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1205675010668	FAD binding domain; Region: FAD_binding_4; pfam01565
1205675010669	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1205675010670	short chain dehydrogenase; Provisional; Region: PRK07904
1205675010671	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1205675010672	NAD(P) binding site [chemical binding]; other site
1205675010673	active site
1205675010674	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
1205675010675	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
1205675010676	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
1205675010677	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
1205675010678	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
1205675010679	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1205675010680	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
1205675010681	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1205675010682	FAD binding site [chemical binding]; other site
1205675010683	substrate binding site [chemical binding]; other site
1205675010684	catalytic residues [active]
1205675010685	Evidence 2b : Function of strongly homologous gene; PubMedId : 12657046; Product type e : enzyme
1205675010686	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1205675010687	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1205675010688	Evidence 2b : Function of strongly homologous gene; PubMedId : 12657046; Product type e : enzyme
1205675010689	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1205675010690	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1205675010691	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1205675010692	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675010693	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675010694	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1205675010695	active site
1205675010696	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1205675010697	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1205675010698	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675010699	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1205675010700	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
1205675010701	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1205675010702	acyl-activating enzyme (AAE) consensus motif; other site
1205675010703	active site
1205675010704	Cutinase; Region: Cutinase; pfam01083
1205675010705	Predicted esterase [General function prediction only]; Region: COG0627
1205675010706	Putative esterase; Region: Esterase; pfam00756
1205675010707	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
1205675010708	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1205675010709	active site
1205675010710	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1205675010711	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1205675010712	active site
1205675010713	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1205675010714	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1205675010715	UDP-galactopyranose mutase; Region: GLF; pfam03275
1205675010716	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1205675010717	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1205675010718	amidase catalytic site [active]
1205675010719	Zn binding residues [ion binding]; other site
1205675010720	substrate binding site [chemical binding]; other site
1205675010721	LGFP repeat; Region: LGFP; pfam08310
1205675010722	PE family; Region: PE; pfam00934
1205675010723	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1205675010724	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1205675010725	active site
1205675010726	motif I; other site
1205675010727	motif II; other site
1205675010728	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1205675010729	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1205675010730	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1205675010731	putative acyl-acceptor binding pocket; other site
1205675010732	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1205675010733	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1205675010734	putative acyl-acceptor binding pocket; other site
1205675010735	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1205675010736	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1205675010737	putative acyl-acceptor binding pocket; other site
1205675010738	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
1205675010739	Phosphotransferase enzyme family; Region: APH; pfam01636
1205675010740	active site
1205675010741	ATP binding site [chemical binding]; other site
1205675010742	antibiotic binding site [chemical binding]; other site
1205675010743	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1205675010744	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1205675010745	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1205675010746	iron-sulfur cluster [ion binding]; other site
1205675010747	[2Fe-2S] cluster binding site [ion binding]; other site
1205675010748	Condensation domain; Region: Condensation; pfam00668
1205675010749	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
1205675010750	PE-PPE domain; Region: PE-PPE; pfam08237
1205675010751	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1205675010752	Condensation domain; Region: Condensation; pfam00668
1205675010753	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1205675010754	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1205675010755	active site
1205675010756	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1205675010757	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1205675010758	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1205675010759	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1205675010760	Enoylreductase; Region: PKS_ER; smart00829
1205675010761	NAD(P) binding site [chemical binding]; other site
1205675010762	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1205675010763	KR domain; Region: KR; pfam08659
1205675010764	putative NADP binding site [chemical binding]; other site
1205675010765	active site
1205675010766	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1205675010767	acyl-CoA synthetase; Validated; Region: PRK05850
1205675010768	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1205675010769	acyl-activating enzyme (AAE) consensus motif; other site
1205675010770	active site
1205675010771	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1205675010772	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1205675010773	Probable transposase; Region: OrfB_IS605; pfam01385
1205675010774	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
1205675010775	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1205675010776	catalytic residues [active]
1205675010777	catalytic nucleophile [active]
1205675010778	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1205675010779	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1205675010780	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1205675010781	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675010782	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
1205675010783	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1205675010784	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1205675010785	Cupin domain; Region: Cupin_2; cl17218
1205675010786	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1205675010787	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1205675010788	seryl-tRNA synthetase; Provisional; Region: PRK05431
1205675010789	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1205675010790	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1205675010791	dimer interface [polypeptide binding]; other site
1205675010792	active site
1205675010793	motif 1; other site
1205675010794	motif 2; other site
1205675010795	motif 3; other site
1205675010796	Septum formation; Region: Septum_form; pfam13845
1205675010797	Septum formation; Region: Septum_form; pfam13845
1205675010798	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
1205675010799	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1205675010800	catalytic core [active]
1205675010801	prephenate dehydratase; Provisional; Region: PRK11898
1205675010802	Prephenate dehydratase; Region: PDT; pfam00800
1205675010803	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1205675010804	putative L-Phe binding site [chemical binding]; other site
1205675010805	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pr : putative regulator
1205675010806	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12657046; Product type pr : putative regulator
1205675010807	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1205675010808	Ferritin-like domain; Region: Ferritin; pfam00210
1205675010809	ferroxidase diiron center [ion binding]; other site
1205675010810	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
1205675010811	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1205675010812	putative active site [active]
1205675010813	catalytic site [active]
1205675010814	putative metal binding site [ion binding]; other site
1205675010815	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
1205675010816	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1205675010817	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1205675010818	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1205675010819	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1205675010820	Predicted membrane protein [Function unknown]; Region: COG2119
1205675010821	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1205675010822	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1205675010823	Fimbrial protein; Region: Fimbrial; cl01416
1205675010824	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1205675010825	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1205675010826	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1205675010827	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1205675010828	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1205675010829	hypothetical protein; Provisional; Region: PRK07945
1205675010830	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1205675010831	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1205675010832	active site
1205675010833	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1205675010834	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1205675010835	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1205675010836	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1205675010837	active site
1205675010838	dimer interface [polypeptide binding]; other site
1205675010839	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1205675010840	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1205675010841	active site
1205675010842	FMN binding site [chemical binding]; other site
1205675010843	substrate binding site [chemical binding]; other site
1205675010844	3Fe-4S cluster binding site [ion binding]; other site
1205675010845	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1205675010846	domain interface; other site
1205675010847	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1205675010848	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1205675010849	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
1205675010850	EspG family; Region: ESX-1_EspG; pfam14011
1205675010851	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
1205675010852	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675010853	Walker A motif; other site
1205675010854	ATP binding site [chemical binding]; other site
1205675010855	Walker B motif; other site
1205675010856	arginine finger; other site
1205675010857	Protein of unknown function (DUF690); Region: DUF690; pfam05108
1205675010858	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1205675010859	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1205675010860	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1205675010861	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1205675010862	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1205675010863	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1205675010864	PPE family; Region: PPE; pfam00823
1205675010865	Proteins of 100 residues with WXG; Region: WXG100; cl02005
1205675010866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1205675010867	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1205675010868	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1205675010869	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
1205675010870	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
1205675010871	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1205675010872	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1205675010873	active site
1205675010874	catalytic residues [active]
1205675010875	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
1205675010876	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1205675010877	Walker A motif; other site
1205675010878	ATP binding site [chemical binding]; other site
1205675010879	Walker B motif; other site
1205675010880	arginine finger; other site
1205675010881	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
1205675010882	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1205675010883	catalytic residues [active]
1205675010884	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1205675010885	active site
1205675010886	catalytic residues [active]
1205675010887	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1205675010888	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1205675010889	EspG family; Region: ESX-1_EspG; pfam14011
1205675010890	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1205675010891	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1205675010892	PPE family; Region: PPE; pfam00823
1205675010893	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1205675010894	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1205675010895	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1205675010896	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1205675010897	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1205675010898	Protein of unknown function (DUF690); Region: DUF690; pfam05108
1205675010899	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1205675010900	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1205675010901	catalytic residue [active]
1205675010902	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
1205675010903	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
1205675010904	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1205675010905	active site
1205675010906	NTP binding site [chemical binding]; other site
1205675010907	metal binding triad [ion binding]; metal-binding site
1205675010908	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1205675010909	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1205675010910	Zn2+ binding site [ion binding]; other site
1205675010911	Mg2+ binding site [ion binding]; other site
1205675010912	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1205675010913	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1205675010914	active site
1205675010915	Ap6A binding site [chemical binding]; other site
1205675010916	nudix motif; other site
1205675010917	metal binding site [ion binding]; metal-binding site
1205675010918	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1205675010919	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1205675010920	RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643
1205675010921	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1205675010922	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1205675010923	DNA binding residues [nucleotide binding]
1205675010924	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1205675010925	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1205675010926	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1205675010927	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1205675010928	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1205675010929	catalytic residues [active]
1205675010930	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1205675010931	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1205675010932	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1205675010933	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1205675010934	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1205675010935	active site
1205675010936	metal binding site [ion binding]; metal-binding site
1205675010937	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1205675010938	ParB-like nuclease domain; Region: ParB; smart00470
1205675010939	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1205675010940	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1205675010941	P-loop; other site
1205675010942	Magnesium ion binding site [ion binding]; other site
1205675010943	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1205675010944	Magnesium ion binding site [ion binding]; other site
1205675010945	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
1205675010946	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1205675010947	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1205675010948	G-X-X-G motif; other site
1205675010949	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1205675010950	RxxxH motif; other site
1205675010951	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
1205675010952	Uncharacterized conserved protein [Function unknown]; Region: COG0759
1205675010953	ribonuclease P; Reviewed; Region: rnpA; PRK00588
1205675010954	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399